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<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M3AQZ6</accession>
    <name>M3AQZ6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_55199</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456288">
        <property type="protein sequence ID" value="EMF07894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AQZ6"/>
    <dbReference type="STRING" id="692275.M3AQZ6"/>
    <dbReference type="eggNOG" id="ENOG502S3VE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_170506_1_0_1"/>
    <dbReference type="OMA" id="CPRSIKQ"/>
    <dbReference type="OrthoDB" id="4383808at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF07894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="72" mass="8186" checksum="6BEC933B06264322" modified="2013-05-01" version="1" fragment="single">FIRQVSCYTLLSGFRLPWPPSCCLDELTPFVVSDERIFRHLNLAFGSSRIASSAYQKWPTSNGAFKCPRSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M3ARZ7</accession>
    <name>M3ARZ7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Aconitate hydratase, mitochondrial</fullName>
            <shortName evidence="9">Aconitase</shortName>
            <ecNumber evidence="9">4.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_151977</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756400.1">
        <property type="nucleotide sequence ID" value="XM_016907166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3ARZ7"/>
    <dbReference type="STRING" id="692275.M3ARZ7"/>
    <dbReference type="GeneID" id="27904303"/>
    <dbReference type="eggNOG" id="KOG0453">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006714_2_2_1"/>
    <dbReference type="OMA" id="KWPETFG"/>
    <dbReference type="OrthoDB" id="2224430at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000002">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000003">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000004">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1060.10:FF:000001">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1060.10">
        <property type="entry name" value="Aconitase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050926">
        <property type="entry name" value="Aconitase/IPM_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015932">
        <property type="entry name" value="Aconitase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006248">
        <property type="entry name" value="Aconitase_mito-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01340">
        <property type="entry name" value="aconitase_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005558">
        <property type="entry name" value="PRK07229.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160">
        <property type="entry name" value="ACONITATE HYDRATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160:SF2">
        <property type="entry name" value="HOMOCITRATE DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="6 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="10">
        <location>
            <begin position="102"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="11">
        <location>
            <begin position="609"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF08279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="811" mass="86596" checksum="15DD886BB08BFEC0" modified="2013-05-01" version="1">MLAARRTATARSTLLSLPTPLRTHIASSRTLATATDASVTPAASSVESRTPPYAKLLQRLQSVRRLLPTRPLTLAEKILFSHLDNAEESLLQGTNNGKDIRSNATLKLKPDRVAMQDASAQMALLQFMSCGMPTTAVPASIHCDHMIVGEKGADIDVPNSIKGNKEVYDFLESAGKRYGIEFWPPGAGIIHQTVLENYSAPGLMMLGTDSHTPNAGGLAAIAIGVGGADAVDALVDAPWELKAPKIRGVRLEGKLSGWASPKDVILALAGKLTVRGGTGYITEYFGPGVASLSCTGMATICNMGAEVGATTSIFPYTPGSHDPYLQSTHRGSIAKAANAIAQSPDTSNLLAADSNCEYDEVVTINLSELEPHINGPFTPDLSTPLSKFKEAVQMNKWPETFGAGLIGSCTNSSYADMTRAESLVQQAQAAGLKPKADFFISPGSEQIRATLERDGTLETLQEGGGLVLANACGPCIGMWSRTDGVKKGEDNAIFTSYNRNFPARNDGNRKTMNFLASPDLVTAMSYAGRTDFNPMTDSLTTPSGESFRFQPPKGTELPSLGFAAGNPMFRPTEPVPNPNVSIAVDPDSTRLELLEPFAPFPEGELSGLKVLVKVKGQCTTDTISAAGPWLKYKGHLTNISENTLIGAVNAETGEVNQVSDVDGAQYTIPELGKKWKAQNQPWLVVAEHNYGEGSAREHAALQPRFLGARIILTKSFARIHETNLKKQGVIPLTFENEADYDKMAGCDEVSTEGLYDVLQGGNGKISLIVKKKDSGETFKVPVKHTFSPDQKSFILAGSALNLLAKKGQMKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M3AVT6</accession>
    <name>M3AVT6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_135532</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758312.1">
        <property type="nucleotide sequence ID" value="XM_016902720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AVT6"/>
    <dbReference type="STRING" id="692275.M3AVT6"/>
    <dbReference type="GeneID" id="27899857"/>
    <dbReference type="eggNOG" id="KOG2809">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052839_0_0_1"/>
    <dbReference type="OMA" id="PCWDQSS"/>
    <dbReference type="OrthoDB" id="29523at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="25"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="305"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF10191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="375" mass="41160" checksum="1626B300EE8A4F3A" modified="2013-05-01" version="1">MGLAGNKKKGKLSTDPNNTAWAKSTTSFGHKMLSKQGWKPGDFLGAENASHASHYTAANASHIKVMLREENLGIGAKIGTQNAETFGLSMFSGLLGRLNGKEEDRAVMQKKEETLRDVQLKLKYGNMNFVSGGMLVGDKMQEVKTDLGHLKDGGVVAVQESKKRKAGSDGSEEDEKSAKKRRKAEEKEKKKKKEKKANGTAAAIKEMKRQRKLEAGSDTPPTSKESPEQEADSSSTTSSSSEDEQESKRGKKAQRKTSKSPKRSSSSSSDVKDDEKARLKEEKRARKEERRKRKEEKRAKRAAKALKSSSTIITKTTTTQPGSTTESETQSGTSTPTFLGGRQAVRHRYIMQKRMAGASAQALQEIFMMKPQVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M3AWF5</accession>
    <name>M3AWF5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_134301</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Vesicular transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759201.1">
        <property type="nucleotide sequence ID" value="XM_016902631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AWF5"/>
    <dbReference type="STRING" id="692275.M3AWF5"/>
    <dbReference type="GeneID" id="27899768"/>
    <dbReference type="eggNOG" id="KOG3764">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_51_3_1"/>
    <dbReference type="OMA" id="REYWVSV"/>
    <dbReference type="OrthoDB" id="5086884at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17325">
        <property type="entry name" value="MFS_MdtG_SLC18_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF29">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G10530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="284"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="418"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="34"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="475"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="485"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF11080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="536" mass="58673" checksum="82CA1E39C8D87766" modified="2013-05-01" version="1">MDWNSNMMQMMRPYSAASDFVEKIQRLRSNSTYLVVVVSLSFFTDLLAYGVIVPVLPTALITRAGVEPGHEGFWISILLICESASALIASPIAGHLVDAHDTRKTFFLLAIALLFGSILWTALSTSIPLFILGRCIQGAATAWVRVSGFAMVADVIPEEKIAVTLGWLGAANTAGFTVGPVLGGVLFTYGGWWTVFGTLLGMLFLDFCLRCTVTERKRVIEEEDEYEGEGEREDEIEVEGENTTIYDHDDEAILQPTVPRKMKKKEKKKRENGLIVLARQPRMICMLCGVVTSGILISSFDATLPLFVQDRFHWDALGQGLIFLPTALPALLDPVYGYLINKFGVRKCATTAFLVLCPILLSLRFITTSTLLHKTLLITLLTLLGSALNVADVSLLVETDDVVRHLRETQPQLLSPRGAIAQSFGLQTMGYHLGVLLGPLGAGMLNQYEGWEWMTVALGALAGCMAGVMLGVGKKKNRKGRGGEEELGDGEDQEVEMQGLMGTRRGGGGKRGEGQWVEESVERLGKTHIPRRLPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>M3AWH0</accession>
    <name>M3AWH0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SEPMUDRAFT_150114</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759216.1">
        <property type="nucleotide sequence ID" value="XM_016905971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AWH0"/>
    <dbReference type="STRING" id="692275.M3AWH0"/>
    <dbReference type="GeneID" id="27903108"/>
    <dbReference type="eggNOG" id="KOG0598">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_52_3_1"/>
    <dbReference type="OMA" id="QWAEYIS"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904828">
        <property type="term" value="P:positive regulation of hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060963">
        <property type="term" value="P:positive regulation of ribosomal protein gene transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045945">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901494">
        <property type="term" value="P:regulation of cysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032880">
        <property type="term" value="P:regulation of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047484">
        <property type="term" value="P:regulation of response to osmotic stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090153">
        <property type="term" value="P:regulation of sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000008">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000116">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="C2" evidence="12">
        <location>
            <begin position="101"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="309"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="14">
        <location>
            <begin position="571"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="33"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="679"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="100"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMF11095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="709" mass="78622" checksum="676A12DEAC9706C4" modified="2013-05-01" version="1">MSHSSDAFGQHGAVDLLRQSLMHGRATMAAADDDHHDHIGSGASTPPNGTATPRPDAHHDKRLPQLVNSYFAQNTPPQTPRSGSLASRSNKDDVSHAKAAKSTKSSRSSSSNSQGAVIGSLRGQLEISIEEGRGLKPATDPYVVCIFQLNEDISGGPKEDEMAIDDDKPHEENLAKGVAMKRMGSGQGVAMAIPGLKSRQTSQTNIADLRRGLHYKQQETTDPVWRHKATFDVVGDNNEIDISVYDRANNESFIGHVRMPLDLSDYEHQHEDWFKLQPREGLDETVSGELHIKLAFHIAGKKSFGPDDFEILKLIGKGTFGQVFQVRKRDTKRIYAMKVLSKKVIVQKKEIQHTIGERNILVRTATTESPFIVGLKFSFQTAADLYLVTDYMSGGELFWHLQKEGRFVEERAKFYIAELILALRHLHQHDIVYRDLKPENILLDANGHIALCDFGLSKANLAKNDTTNTFCGTTEYLAPEVLLDEQGYTKMVDFWSLGVLVFEMCCGWSPFYAEDTQQMYKNIAFGKVRFPRDALSAEGRSFVKGLLNRNPAHRLGAKADAEELMAHPFFNDIDWVALGKKSIAPPFKPKLKGELDTSNFDPEFTNALTSGDQNSLNARAAALASGIHDESTPLSPTMQNQFKGFTFVDESTLEQHYADRNEGMYGIDNNGLSRTFSNKAGDRMSGLEPTSAKTESADGDFNHGMLDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M3AWW5</accession>
    <name>M3AWW5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptide hydrolase</fullName>
            <ecNumber evidence="11">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SEPMUDRAFT_88567</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="11"/>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759336.1">
        <property type="nucleotide sequence ID" value="XM_016910477.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AWW5"/>
    <dbReference type="STRING" id="692275.M3AWW5"/>
    <dbReference type="GeneID" id="27907614"/>
    <dbReference type="eggNOG" id="KOG2195">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024336_1_1_1"/>
    <dbReference type="OMA" id="AHFQQTQ"/>
    <dbReference type="OrthoDB" id="10013407at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04816">
        <property type="entry name" value="PA_SaNapH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF26">
        <property type="entry name" value="PEPTIDASE M28 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="9 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PA" evidence="12">
        <location>
            <begin position="84"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="13">
        <location>
            <begin position="205"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMF11215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="462" mass="48875" checksum="6ECE1619A81656B4" modified="2013-05-01" version="1" fragment="single">MQNLQSLEDIAKANGGNRAFGLPGYDASRDFVLSKVGNSTTWKAWTQDFPALYNDVVSITFRVGDTEYYVFGPTYSPSTGADGITAPLVLGPNGTTACTVAGYSGLDVQDKMVLVQRGTCPDNTTIAGRIRAAVSAGANSVILYNNVPTKVTGGTLSAPDPVGYRPSGFINQDDGEALKARLEAGEVLEGYLQHTQTIEERITQNVFAESLGGDPNNVIMMGAHLDSVKAGAGINDDGSGTTLVLEVFDGLQQASFQNKIRLAWWGAEENGLVGSRYYTTGINNTVEADNLVAYLNFDMVSRGYYGVFDGDGNTHGVVGAPGSDVIEKLFVDHLTGQGFNVTPAVFTGGSDYASFMSTLNKPVGGLHTGTGVAQDDCYHQECDGYSNANPEQLTANAKAAAHVLATLASEGHLIIPKGEKKAARDVEKLHERSLEGAIADHELFGFSEVPGERHTGSCGHDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M3AXC7</accession>
    <name>M3AXC7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_150330</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759506.1">
        <property type="nucleotide sequence ID" value="XM_016906096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AXC7"/>
    <dbReference type="STRING" id="692275.M3AXC7"/>
    <dbReference type="GeneID" id="27903233"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_2_1_1"/>
    <dbReference type="OMA" id="ERVPYIR"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF11385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="549" mass="63048" checksum="A747CCB121C33B17" modified="2013-05-01" version="1">MAWISEDVARQKLLVFGLLACLIVFAVTKIEKVVRERKLLPLPPMPPGFPLVGNLPQLQKAGKTREEHLLFQRWAEEYGPLYRVKIGLFTQYMVNTDLAVKEIFDKSARQSADRPPTIVSRDHISNGLSLLTLDSSSPRWKLQRKVTWSNVGSIARANEGLPYLNFETLKFLHEVVSDPKLQTSSNALWGAVKRYTYSNFATQMFGLEIPKLSDPCIEYIHETAEAQVLGTIPGYYVVDILPFLNRLPMFLKPWERNGRERFRRDMRWITEKMHRVQAMSDKERALIKDSLMCKIVEDEKHLGFDTKEEGAYVCMQLTIAGSDTSQASLWCFLEAMMRFPEVQEKAYKLLDEAMGDRIPVFEDHERVPYIRCMVKETLRWRPPVSLGQPHCTSADITFEGMRIPKGSFLHLNAWAVQHNPDRHQDPERFWPERYLNDPTSTMESLNNPDATKRDHFAFGAGRRVCSGYNVAERSLTVAIMRILWTFEVKIAPHAKLPLDTRDWSGLFPGTPGEDMPVMLVPRKHKVPIIQKEFAAAQADRALFQSLDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M3AXS9</accession>
    <name>M3AXS9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">General negative regulator of transcription subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SEPMUDRAFT_150446</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759666.1">
        <property type="nucleotide sequence ID" value="XM_016906179.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.M3AXS9"/>
    <dbReference type="GeneID" id="27903316"/>
    <dbReference type="eggNOG" id="KOG1831">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000286_3_1_1"/>
    <dbReference type="OMA" id="IDEYHCY"/>
    <dbReference type="OrthoDB" id="1933107at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20710">
        <property type="entry name" value="NOT1_connector"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000012">
        <property type="entry name" value="Ccr4-Not transcription complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.840">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 1 TTP binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007196">
        <property type="entry name" value="CCR4-Not_Not1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055454">
        <property type="entry name" value="CNOT1-like_NOT1_connector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032191">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024557">
        <property type="entry name" value="CNOT1_dom_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032194">
        <property type="entry name" value="CNOT1_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032193">
        <property type="entry name" value="CNOT1_TTP_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038535">
        <property type="entry name" value="CNOT1_TTP_bind_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040398">
        <property type="entry name" value="Not1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162:SF8">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25097">
        <property type="entry name" value="ARM_Cnot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16415">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16418">
        <property type="entry name" value="CNOT1_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16417">
        <property type="entry name" value="CNOT1_TTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12842">
        <property type="entry name" value="DUF3819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04054">
        <property type="entry name" value="Not1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 HEAT repeat" evidence="12">
        <location>
            <begin position="429"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 TTP binding" evidence="11">
        <location>
            <begin position="614"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 CAF1-binding" evidence="10">
        <location>
            <begin position="819"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1" evidence="9">
        <location>
            <begin position="1101"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1-like NOT1 connector" evidence="13">
        <location>
            <begin position="1427"/>
            <end position="1538"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-Not complex component Not1 C-terminal" evidence="8">
        <location>
            <begin position="1718"/>
            <end position="2069"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00074459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF25097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMF11545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="2080" mass="233321" checksum="846ADAA37520FFF6" modified="2013-05-01" version="1">MESFATYLRQLLQSSAATNIASPTRAPTGSDDADYYQLFKADLQQMTKDPQQADHIARVLDTSDPDLLRDLNLQPFFDHFDFDAIARVALLQSLATATNADLRHKAATSLVQTFPLALQALAQPLQSTDADINPSPTVLASIVERVIHDPRGSSDELRENLFYAVRIYYRTRGLRTPYAVESAMLLDDLLQSQQDSRLVKKFQAAGPDATASLDACKEVLASAETRDISYPQIANVLLYMIIVQDGEAYNPSVFVEAVRQHRAGARIDWTDVVTGFDKEGLRVTKKQFLALYNALLPLAREYANFDIQLLWGGQWQWSETQLSFVVAFLSTKPEELDVMQIPNLRQAFDLTHYATASVTVRACAEAAIKHPLVSKDATQALFSMIFRSQDTYNMSQQLGIPDTIVNPNMATFVCAAAATDRPWGPLQEQAMKQLFYPFLIKRHDSHEFVMHTLWHHDKTWVASRLVDYYTPEPLLLPIIYDHALVHGWLELLFTLPTSFAVDLAAYAHGKGHCDLVAFAQNHMTSMGPGNFAVAITQFVEGKVDDELLVQKEGVAASSAPLTVKTLHALLELIADAMFEEHKGDVFRKCLTTYPRLINYGEDDQRDALLDTSDEQGHALPQGATDHMEQQYKDMYGAQTNPSDVITELKRLKESEDPMEQDLFAAMICGLFDEYHCFSEYPNEALALTAVLFGGLISYRVLSGIAEQAAICSVFDAVSRFQPEDQMYRFGLQALLHVLPRLKEWPQLAERILHIPSLRSTDAVTAAENVLRELQQESGGMNGDGTNGIANGVLDDEDFEVMAPAFSAIQVDPPNMEIEYEEPNEETSDKVMFVLNNVSKRNLEEKFKEIEEALDEKYTQWFAHYLVDELAKSQPNFQALYLQILENFNRKLLWAEVLRETYISCQKMLNAQSTLDNSHERATMKNLAGWLGQITLARSLPILHRNLSFKDLLLEAYDNERLLVAIPFTCKTLVQASNSKVFRPPNPWIQELLGLLSELYHGGKLKLNMKFEIEMLCREFNMDIKDIEPLDIIRTRPSLEQNMLQNYIPEGGPDAFGEMALMGLSKRGPSERFSPEAVMSQVPDLGHMLHIPQAVGTTTPQQMKSIFVTAAQQAIFEIIAPVVERSVTIASISTSELIQKDFVTEPDAGTMSNCAHTVVKSLSGSLALVTCKEPLRMSITNNIRLLAARSLPEQLPEGQILMFVNDNIDTVCRLVEQAAEDHSLAEIDLQLGDAINDRQQHLEHRPNEPFSQVPVSRWSTLIPEPYRQDQNGLNRQQLALYEDFGRQARIPPAGGSASQDGTRPLDVLGDGYLPNMPTPAEAPAMPHPGQNQRMPGMQVARAHVNGLIDPATVNDRIIALMSELQTASREAPEEHISEIGEGATIRRVYGQLLTLIESAPQFENTVLACANHCLLLIYGDAQKRLEIEVLARFLTQLCRMSQQACRQITMTIATVEDDRIFNAPATVALHSEALLDIHHIDSLISKALRQRRLIAMDFFGDIVEDLLLGENAVAHRAEFAQSYEALAQWINSIPVPSPEASSEPLPQELVVAREIMNRLHQAAVHANGLPSPESDSKQVDQQEYLFEEWIKLQKDHQPENYRYLAFVSQLHDRGVLANPEDTVVFYRSCIEYSCSHFEAVTARPYGTFDLAYVGIDALAKLAATLVLYQGSSEASTNTNQAKSLEAFVSLVILVMSDYHNRSVERFNSRVFFRLFSSLLCEIDNNRSQLSSEQDAEVYKVFSTALQVMQPRYFPGFLYSWIALLSHRLLIPAFLVNGRGNGGWNQFTKLLAVLFINLDDLCSSPEAAIVAPEFYRAVVKFMMVLHHDFSDYLVENHMQLNAVIPVQFGHLQNIVSAAVPQTAQLTQPNPFTSGLKINRLEQVRVPPSVYSDVDNVLHEAGVKAVMERVCEANDLSEQNFAFLKAVVDREDGQISPILLNAMVLYVGVTATSASSVFSAGAAQARLITRLLQEIGHRARYHLVWAVTNQLRYVNSHTHYFSTAVQHIFSTSQQDLQEQIMRVICERMLITHPHPWGLLVLLLEMIKNPNYNLLEQPWVRAAPQVEELLLTLTHSNSPHSARH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M3B2T0</accession>
    <name>M3B2T0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_147918</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SO2202</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2012-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genome evolution in poplar pathogens from wild and recently domesticated pathosystems.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Dhillon B."/>
                <person name="Feau N."/>
                <person name="Sakalidis M.L."/>
                <person name="Gill N."/>
                <person name="Aerts A."/>
                <person name="Ohm R."/>
                <person name="LaButti K."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Copeland A."/>
                <person name="Beauseigle S."/>
                <person name="Grigoriev I.V."/>
                <person name="Goodwin S.B."/>
                <person name="Tanguay P."/>
                <person name="Hamelin R.C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762208.1">
        <property type="nucleotide sequence ID" value="XM_016904597.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.M3B2T0"/>
    <dbReference type="GeneID" id="27901734"/>
    <dbReference type="eggNOG" id="ENOG502SJP4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003334_1_0_1"/>
    <dbReference type="OMA" id="AVWWFLR"/>
    <dbReference type="OrthoDB" id="4356615at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056030">
        <property type="entry name" value="DUF7611"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056031">
        <property type="entry name" value="DUF7612"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056032">
        <property type="entry name" value="DUF7613"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056033">
        <property type="entry name" value="DUF7614"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24586">
        <property type="entry name" value="DUF7611"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24587">
        <property type="entry name" value="DUF7612"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24588">
        <property type="entry name" value="DUF7613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24589">
        <property type="entry name" value="DUF7614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7611" evidence="2">
        <location>
            <begin position="742"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7612" evidence="3">
        <location>
            <begin position="900"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7613" evidence="4">
        <location>
            <begin position="1037"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7614" evidence="5">
        <location>
            <begin position="1199"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="472"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF14087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1352" mass="149375" checksum="53AF8059EB59D714" modified="2013-05-01" version="1">MAEDESKTSKASRFLKKSKWVKVLKEREPSEDDPPAPARAGAFTLDNDVVDFLKPSTEKSKPKLDIAIARRWPEAHQVRALGEDSPGPDGPTFTKPRRRKGLTVGFAKTAPEIIGEGGDDAPDPPTEIGRRKAAMGRSVSDATPAVRSLALPMHGQPTAQARGYPPQPPEETPAAPPIRRINTSHREFSPPISRKLAAPPVGDIEPLRPSIGRVNTGLGNSTTLQTPGDDSASSNPPPSRQQPGRLDTEFQFEGRPSAAGLGSIRAHLAPESATSDEASSPVVQKRREMTRNEGMAFRRASMLVKKDSEEDEIERSSGEHEESHKPPAIARHSGDSGVYSSTEALSQSPEIGITPDAPNPVADREDTTRHLRDASPSPQHQLEPPTQSLGQDLSEREVNNHAQIPLPPPRSPLRGIYATRASPQPSMAIPIDHARDNSRSPRLSDRLFDASTSSQQSTAVYSKPNGSSSSVNRFPNRSSHSRPSSRDDGAPPRMQSAGPGSQPPYSSRVQNGASSANSPRSSLLVPGRTGASPAPLPVHRTQDYVAATTIPPPSKSPAAVLRHEEKPRPLSSSSTYSLSRPAAWSLNPTENNPAADAAFADFEARVAHMRGVFRLTAEKELSGDRCTPSMWLRAALWWYHTGKTGLEALFARRGPNERRELLTQPHVDLAKTWWILRDPLNHLDMADGEAHESDPNANMIRRSIAALKSSLKTLSLSLTKNHMLPPESSLIQGQNTQIWIEYPRFTSDVQAVLGGSVSSSVLVQDSKQAVDPYEVLPLNDTNDHFWYGRFPVEVYLHTEDLETDRVMLPCLLTVLRGRHDYQTSVTIASQSELVNIKIMPQQDRRRGLTWSDVSWEASPASMSIRLPRNFDLSVRMQERDYRALWNLSEYARKVERTMQPNSDERLVHECRLTELQYVDSSNSSSFPSEKIRGCSAFIFERTDKHVGGTGTRRLHRGYRLLLVTDPGHKTLSAVSHDICGRSPFYFEFLTDSAAGGTTAMVVRIWEAQRQCRILLVFPDAGSRQSLYNIINGLAVRSDESIVGKMVLASLNIEPASPSLSFSQSGHVALQKLNWQKLGITNSVPDDSNSRFPATIESESLRILARHDTGCITDRVNLGKGELLLRLPPSDSPSVQILRDPQEDMTVSIDTRQSHATVVNGIAEVLKTVLEQQTIRTFTFQSHSDLHAFQAAVTGCTVRFDGMAASLDISRRRMVVPIYKKWQAQSVRIQIVSQGQIVQLLAFMEEFSHADALCFQVKSTDVFETHKGDSKGKKWTVKMVDAKFTLPNREKGKDESAEEQLKNRFVNLENLEYAEEHDDITIGFDTEQDRDRFAHALPAATSVSRGITLKRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M3B592</accession>
    <name>M3B592_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acetyl-CoA hydrolase</fullName>
            <ecNumber evidence="4">3.1.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Acetyl-CoA deacylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_146951</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + H2O = acetate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20289"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="3.1.2.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyl-CoA hydrolase/transferase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.1" evidence="4"/>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF14927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763048.1">
        <property type="nucleotide sequence ID" value="XM_016903983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B592"/>
    <dbReference type="STRING" id="692275.M3B592"/>
    <dbReference type="GeneID" id="27901120"/>
    <dbReference type="eggNOG" id="KOG2828">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019748_3_0_1"/>
    <dbReference type="OMA" id="SCIVPMV"/>
    <dbReference type="OrthoDB" id="10250396at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008775">
        <property type="term" value="F:acetate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003986">
        <property type="term" value="F:acetyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006083">
        <property type="term" value="P:acetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.750.70:FF:000002">
        <property type="entry name" value="Acetyl-CoA hydrolase Ach1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1080.10:FF:000003">
        <property type="entry name" value="Acetyl-coA hydrolase Ach1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1080.20:FF:000001">
        <property type="entry name" value="Acetyl-CoA hydrolase Ach1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.70">
        <property type="entry name" value="4-hydroxybutyrate coenzyme like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.20">
        <property type="entry name" value="Acetyl-CoA hydrolase/transferase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.10">
        <property type="entry name" value="Glutaconate Coenzyme A-transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026888">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038460">
        <property type="entry name" value="AcetylCoA_hyd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046433">
        <property type="entry name" value="ActCoA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003702">
        <property type="entry name" value="ActCoA_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43609">
        <property type="entry name" value="ACETYL-COA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43609:SF1">
        <property type="entry name" value="ACETYL-COA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13336">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02550">
        <property type="entry name" value="AcetylCoA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-CoA hydrolase/transferase N-terminal" evidence="9">
        <location>
            <begin position="14"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Acetyl-CoA hydrolase/transferase C-terminal" evidence="10">
        <location>
            <begin position="333"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF14927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="526" mass="58673" checksum="ACF4F27FA29C657C" modified="2013-05-01" version="1">MAASALLKSRVRRPSYLNRLAQAEDLIDLFPHNSYIGWSGFTGVGYPKKVPTALAEHVERNNLQGKLKYHLFVGASSGAETENRWARNNMIERRAPHQVGKEIAKGINNGNIKFFDKHLSMFPVDLMYGFYTKNKENNRLDVAIVEASAITEDGGIIPGASVGASPEIIQMADKIIIEVNTASPNLEGLHDITMTDLPPRRKPYLVMSPEDRIGTPHIPLDPEKVVAIVESDYADQTQPNAPEDDNSKAIAHHLIEFLKHEVNHGRLPPNLLPIQSGIGNIANAVVGGLASGGADFKNLKVWTEVLQDSFLDLFDSGNLDFATATSIRFSPDGFHRFYDRYKDYAPKLLLRSQQVSNSPEIIRRLGVIGMNTPVEVDIYAHANSTCVMGSRMLNGLGGSADFLRSAKYSIMHTPSTRPSKTDPTGVSCIVPMCTHVDQTEHDLDVVVTEQGFADVRGMSPKERAREIIKKCAHPDYYPILKDYFDKAEFECMRKGWGHEPHLLWNAFDMHKHLNEHGTMKLPKWQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M3B782</accession>
    <name>M3B782_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thiolase-like protein type 1 additional C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_60854</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763833.1">
        <property type="nucleotide sequence ID" value="XM_016909542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B782"/>
    <dbReference type="STRING" id="692275.M3B782"/>
    <dbReference type="GeneID" id="27906679"/>
    <dbReference type="eggNOG" id="ENOG502QTZI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026848_0_0_1"/>
    <dbReference type="OMA" id="YGPVGGE"/>
    <dbReference type="OrthoDB" id="435240at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040771">
        <property type="entry name" value="TLP1_add_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF139">
        <property type="entry name" value="THIOLASE-LIKE PROTEIN TYPE 1 ADDITIONAL C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18313">
        <property type="entry name" value="TLP1_add_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase-like protein type 1 additional C-terminal" evidence="4">
        <location>
            <begin position="428"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF15712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="531" mass="58305" checksum="87CF3FA11D9B30AF" modified="2013-05-01" version="1">MSRSPRKTPVIVGIGDVVNRSKSVEDAIEPLQLMIQAIEKAIQDTGLAAAALVKLQKNIDSISVVKTWTWPADYPSLIADRLAVKPLHAEYSDHGGNQPAKLVDEAARRISRGENKVAIVTGAEALASLTACAAAKKMPPPGWTPPSEDVQSVFSPTTRELQQDYGARHFCANPIQLYPLYENAFRAHRGQTIEANHVESAKLYADFAKVAEQNENAWSYPAPAETEASIATIGKRNRMICHPYPLLMNAFNTVNCSAACIVTSTDHARELGIPYEKWIYPLGGAGTSDSPEYWLRPEYWWSPSLSRSLDAALDVSGVYTEEIDLYDIYSCFPIVPKLAAHHLHLPPVTTGGGGEKRSLTLLGGLTSFGGAGNNYSMHAITEMTRQLRTGKGKTGLVLANGGWLTYQHVLLMSRSPRKDGLPYPDENPLPKVVHDVQVPRIEEKPPEGEAIVETYTVDYNRDGTPARGHVVGRLLNGHRFVANHADQETLEELSSWQKEPIGRRGWVRTGKDGRNLFTFNTSSGELPLAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M3B7T9</accession>
    <name>M3B7T9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_114959</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764018.1">
        <property type="nucleotide sequence ID" value="XM_016901120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B7T9"/>
    <dbReference type="GeneID" id="27898257"/>
    <dbReference type="HOGENOM" id="CLU_1295121_0_0_1"/>
    <dbReference type="OrthoDB" id="194139at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF15897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="213" mass="24152" checksum="D6358E7C3147F6F4" modified="2013-05-01" version="1">MQSGLKKVLLSYDGNTVANGSGVDTGLLDILDAVSEPIVALERHAPTTLYGTLPGTLLTLHLPFRWMATLVLEQTPLLLYIRDEHYEVTASQAPEAENALETVQQDHSSFTSSRYGRQLCFLIFLREFSQYLVYARLMAVFEDIICTRHYSKTTHCLLKDCKIVSVPNELAFLEVADFLPVCYYRSFPVDYSGVAVRGRRHITKLWGTHFRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M3BQ11</accession>
    <name>M3BQ11_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RAD52 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_144910</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RAD52 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756369.1">
        <property type="nucleotide sequence ID" value="XM_016903085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BQ11"/>
    <dbReference type="STRING" id="692275.M3BQ11"/>
    <dbReference type="GeneID" id="27900222"/>
    <dbReference type="eggNOG" id="KOG4141">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011431_4_0_1"/>
    <dbReference type="OMA" id="NLHRHAD"/>
    <dbReference type="OrthoDB" id="206565at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045002">
        <property type="term" value="P:double-strand break repair via single-strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.80:FF:000001">
        <property type="entry name" value="DNA repair protein RAD52 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.80">
        <property type="entry name" value="DNA repair protein Rad52/59/22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004585">
        <property type="entry name" value="DNA_recomb/repair_Rad52"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041247">
        <property type="entry name" value="Rad52_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007232">
        <property type="entry name" value="Rad52_Rad59_Rad22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042525">
        <property type="entry name" value="Rad52_Rad59_Rad22_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00607">
        <property type="entry name" value="rad52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12132">
        <property type="entry name" value="DNA REPAIR AND RECOMBINATION PROTEIN RAD52, RAD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12132:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04098">
        <property type="entry name" value="Rad52_Rad22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="195"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="512"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="232"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="247"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="275"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="292"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="316"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="356"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="372"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="559"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="571"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00077224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF08248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="586" mass="62285" checksum="41A93615BD6B3B4D" modified="2013-05-01" version="1">MPAPGDQHRDNANTVNPFVKSEPRISEYTAQEIATLQSRLEKQLGPEYISTRPGAGGGKVHYLAAEKVINLANEVFGFNGWSSSIQNVQIDFVDENRETGRINLGLSTIVRVTVKDGTFHEDIGYGHCENTKGKAAAFEKAKKEAATDAMKRALRNFGNVLGNCLYDKEYLQKITKVKVAPSKWTTDNLHRHPDYAVVKKEPTIQAAPTPGRDNGSRRNTSLQSAHSAGSGEFDDDFGETAEFDETDFSHPDEVRLDDSEISNGPPAHVQRAIGPQQNGQRQAMSRTHSMPTIPPPNIQPPAPVTRMQAPPKPQAVQRQPQNAAQSAQRMVPPQTPGNQQRAQAQPQPQPQPQPQPQQTTNKNAQQNPDGVRSNSSSGSTLESPTAHAQQRPHHPANVQAQVDEPSMPPPGAAVGFMSGRALAKPDANPAFNPHAESPSIRRTQGVNPRVSAPIRREQLAAGQPLTGQQPAAQATAGGAGGFKPVSVGAGNIVGGASRPTATNYINPAADTSRKIGMPLAGGGFRNSNGYKPPGAATKRPAMSDVTNTYGGDGASDGVGEVKKAKVEKGTSTENAAPDTGQNPATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M3BR74</accession>
    <name>M3BR74_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GPI anchored protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_152239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756744.1">
        <property type="nucleotide sequence ID" value="XM_016907322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BR74"/>
    <dbReference type="STRING" id="692275.M3BR74"/>
    <dbReference type="GeneID" id="27904459"/>
    <dbReference type="eggNOG" id="ENOG502SWWX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1422235_0_0_1"/>
    <dbReference type="OMA" id="ANACNGS"/>
    <dbReference type="OrthoDB" id="5242418at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032041" description="GPI anchored protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF08623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="191" mass="19542" checksum="B8C779B2396B20A4" modified="2013-05-01" version="1">MARILSWARLVLVGYAVAASAADSVQLFIDNMDPNAQWAASVANACNGSTTYVVSQTSAPGGGNGEKATITEGPNFYQATTPAVYSETSATMHESCAINSAESSALCVVTVVAANYNTGDAISKTISYNLTGTGYYQYDVKITAGASHTANGGSCVAKSNTANSSISARGSREVLLTAFVILAGVGGVLWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M3BXR7</accession>
    <name>M3BXR7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-lactamase/transpeptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_156462</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760997.1">
        <property type="nucleotide sequence ID" value="XM_016907673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BXR7"/>
    <dbReference type="STRING" id="692275.M3BXR7"/>
    <dbReference type="GeneID" id="27904810"/>
    <dbReference type="eggNOG" id="ENOG502SII7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020027_8_2_1"/>
    <dbReference type="OMA" id="GGHRINE"/>
    <dbReference type="OrthoDB" id="5946976at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050491">
        <property type="entry name" value="AmpC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825:SF9">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825">
        <property type="entry name" value="D-ALANYL-D-ALANINE-CARBOXYPEPTIDASE/ENDOPEPTIDASE AMPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="3">
        <location>
            <begin position="46"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="399"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="405"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF12876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="548" mass="60282" checksum="435977E69B1210C2" modified="2013-05-01" version="1">MGVLKDLETFVVNAAQLREAGIPSVSMAFLDDPLSPVQHHVMSSGAENAETVYQACSISKAITALAVAKLVDQGRLSYDTKIIEHIPPPIAESIVDDKTEHLLQHVTVGMLLSHRSGLSQHGFPGYVGEPAKYPELFSGKPPSNTPRIRFTSLPGSQYSYSGGGFTLLQVVLEHITWTPFADFMQETVLIPLGMSRSRYGDPISGDNNYARAYSTAYTPGTSSSRGYHRFTELAAAGLWTTPSDLLKATAAIQRSLYSQNGFLSPKTARKMLTLVAPNDAPSARPMGMGWAMDRTFFGHTGQNEPGYTCYVLGGHRINEIPPIFNNPRLMSLAIMTNSALGWPTIKKLVAAIFTFRVWPLYDTLPANWNMTDFPPYTAPEGLNTGDKWKDFVGHWTSKKIPGSYSSPPTTATTTTTTSSASPPNPQQLQQQQHSPAGTVDTPSHLTSLLTLHDGEWEIFEDNGLPMLAFDGVDQAMRLRPGASPWFRLNGRVDMAFVVDGLELGVRMCFQPKVQGEWRDLQSLMQATQNEDDMWIELVQDAVTVLRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M3BZ31</accession>
    <name>M3BZ31_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">VASt domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_148674</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YSP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761457.1">
        <property type="nucleotide sequence ID" value="XM_016905072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BZ31"/>
    <dbReference type="STRING" id="692275.M3BZ31"/>
    <dbReference type="GeneID" id="27902209"/>
    <dbReference type="eggNOG" id="KOG1032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006864_0_0_1"/>
    <dbReference type="OMA" id="PSGNMIS"/>
    <dbReference type="OrthoDB" id="2162691at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140268">
        <property type="term" value="C:endoplasmic reticulum-plasma membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120015">
        <property type="term" value="F:sterol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13220">
        <property type="entry name" value="PH-GRAM_GRAMDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051482">
        <property type="entry name" value="Cholesterol_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031968">
        <property type="entry name" value="VASt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319:SF4">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16016">
        <property type="entry name" value="VASt"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="VAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1112"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="domain" description="VASt" evidence="9">
        <location>
            <begin position="879"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="210"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="435"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="499"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="552"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="768"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1051"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1208"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="170"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="302"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="363"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="378"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="393"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="457"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="515"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="562"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="786"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1056"/>
            <end position="1065"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF13336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1241" mass="131314" checksum="DB4B3ED89D0632CD" modified="2013-05-01" version="1">MDAGSGAFSRLRPLARTQKGAANVSSSSLASSGDGDDLDSLGLRSSIDNVIGKVKERTSRRSSVDDRGNSEEPPERRLTTFVAKTKRKIRPNRGDNLERASSTESKLAPDVNLSDSSSLMVSGSGGSSLFTDDDEEKVDSYNKPIRPSLSTHNSHSGYLTFSSPEIITQTPAVSSGSDSLVPSQAAPRTEPLANSIPHIIEPSAATTAALEAPAATPLRSPSPASKVRGKLTLNRKKLGDTDSSKSAAGGGLGGLLKTASRRNSVNEKQGSEELGLDGLRIAQSAASESQETPETPERTPTHADTPLPATPPTLTTTPLTLVTPPTPTEPSASATFRSPSPTKGSPASRPLSSVESIRHRRAQSANLPSKLSTTTIAPLTPTLEETKTPGGTLTHGGQGDGSPGFFSSFISATQKAAGSVGSGINILPFQKHKTNSTPQLVDATEGGEEVIPGPESRPTTDLAQGQRSPLAIETLGRGDLNFGHLGISESAPELMASVDDAPHPAHADAPSQNDDGGRKAEEEAAARAVSSAYDKAPSETATVINDSNRPLSIASNERLTLGEETPPRTGTGTDSGNVKRTGSVRSKISGRRKHRGSSATVGTSNSIAAALKDSTSGLAQPGIHGTGHRLTGFAVASSKRNKDFHNQFRSVPEDDYLIEDYSAALQRDILLHGRLYVSEGHICFSSNILGWVTNLVISFDEIISIEKKSTAVIFPNALIISTLQARNTFASFVARDSTYELLIGIWKISHPNLKSSLNGVVLDNAGTGDKTEVAEVPEGENSTTDGSEDEVYDEDADDDAGSFTDGGIGASDVGSNAGDMSLSRKTSGAPVAAAPQPNGSASKGLDANDVAVTGAAAGSEYPGLPSHEPTECTDGLEHYDKSLADTTIPAPLGQVYTLMFGPASGAFMRKWLVEDQKSRELNYADDKTGLDNDHKTFVFDYIKPLYNPMGPKQTKCITTMTLKAFDLDKAVSVDCSSVTPDVPSGSSFTTKTRYCLMWGPNNSTRIVASFTLEWTAKSWLKGAIESGALSGQTDYVKAIVVALKAAVTTKPPVRGPPRKAKRKGGRKEASDMNDVVAQHEPSTAPADASPSWGFFEPVRPLLEPIAAVLRPFLNSQVIIAVLFVLLSYSWLFAGRGGNGVGLTRYSPAERVAAYEEIWKREESALWDWLEDRAGLAGGYDPPVGRVDTQKVLNAKSMGKKLETQRMSERQMDAAIRSTEEKLAALKDAVERKKSSRSQEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M3C068</accession>
    <name>M3C068_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SAC3_GANP-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_163363</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761842.1">
        <property type="nucleotide sequence ID" value="XM_016908050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C068"/>
    <dbReference type="STRING" id="692275.M3C068"/>
    <dbReference type="GeneID" id="27905187"/>
    <dbReference type="eggNOG" id="KOG1861">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015513_0_0_1"/>
    <dbReference type="OMA" id="RAYKPDV"/>
    <dbReference type="OrthoDB" id="199574at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045107">
        <property type="entry name" value="SAC3/GANP/THP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005062">
        <property type="entry name" value="SAC3/GANP/THP3_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436">
        <property type="entry name" value="80 KDA MCM3-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436:SF4">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03399">
        <property type="entry name" value="SAC3_GANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC3/GANP/THP3 conserved" evidence="2">
        <location>
            <begin position="244"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF13721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="516" mass="58274" checksum="6DED47842139870D" modified="2013-05-01" version="1">MAIEPAYTAVRARQTLVPEPVAPTTPPPAQKVEFPQSLKTWVNTAFFEYNNLKTEPAFASISDADIRAKLSATIREAQENGTMQARDWASYPLPHQLLLDERRKSMYMAQNAMLANLHSDLGTYGIASPTANSKKRKSASQELVDENGRAVTPPWKKSHTKSIADRISGPSKKQEKKNNNNKSNAKIGKFDNSEAALERRRQRFGHVSSDLSSPHYRDDSSTVHASSGPIVGTCEILEKRYFRLTAPPHPNTVRPLALLEKALEHVIGRWKDSRDYTYVCDQLKSIRQDLTVQHLKNNFTIRVYEVHARIALEKKDLGEYNQCQTQLRGLYKMKLGENGGSGGNQDEFTAYRILYLIYTRNRTDMNNMLADLTTADKKGPFVRLALNVRQALAAGNYHRFFKLYNEAQDWNMAPFLMDMFIERERVSAMTAICRAYKPDVSSTFLTQELGFAVDEDESVFESDQLRTCLDFIARYGGQHLVQEKDGDVRVTTGKAGNLFEGAKQSAFGRVDIKGQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M3C106</accession>
    <name>M3C106_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_40580</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF13971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762092.1">
        <property type="nucleotide sequence ID" value="XM_016908788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C106"/>
    <dbReference type="STRING" id="692275.M3C106"/>
    <dbReference type="GeneID" id="27905925"/>
    <dbReference type="eggNOG" id="KOG1200">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="OMA" id="WEVANVI"/>
    <dbReference type="OrthoDB" id="417891at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019301">
        <property type="term" value="P:rhamnose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000417">
        <property type="entry name" value="Glucose 1-dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF83">
        <property type="entry name" value="(3R)-3-HYDROXYACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0684">Rhamnose metabolism</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF13971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="265" mass="27990" checksum="666EE8DBB0D7FF1E" modified="2013-05-01" version="1">MATATTALLLEGKVAAITGAVTGIGRAIALDYLEHGARVAVNYYPDDKSTRQFEALQDEVGADYQDMLIGLPGDITKPETGQELVKRTVEKFGRLDIFVSNAGVCQFADFLTMSPDLVNHTITTNLNGAFFAIQAAAQQMSRQEPCGGSIIGISSISALVGGAGQTHYTPTKAGILSLMQSTACALGKYGIRCNALLPGTIRTQLNDEDLASADKRSYMEGRIPLGRLGQPKDLAGPAVFLASDLSEYVTGAQLLVDGGLFVNLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M3C376</accession>
    <name>M3C376_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sec1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_148363</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762857.1">
        <property type="nucleotide sequence ID" value="XM_016904875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C376"/>
    <dbReference type="STRING" id="692275.M3C376"/>
    <dbReference type="GeneID" id="27902012"/>
    <dbReference type="eggNOG" id="KOG1301">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016216_2_0_1"/>
    <dbReference type="OMA" id="VNDLRAW"/>
    <dbReference type="OrthoDB" id="10251230at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035543">
        <property type="term" value="P:positive regulation of SNARE complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046578">
        <property type="term" value="P:regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="594"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="607"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF14736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="693" mass="76162" checksum="21A456C03FA96694" modified="2013-05-01" version="1">MSTYHSLRDRQVASIERILNLNHAPDPSDSTLDSTASNGLVTKSTPILNADGEPIWKVLVFDALGRDVISSVLRVSDLRSWGVTIHLNINGQRHPIPDVPVLYLVEPTAENLQRITQDLQKGLYSPAYINFLSSISRPLLEDFATQTAEAGTAASISQVYDQYLNFIVSEPNLFSLGMGKETYWAMNSAQTSDESIDSNVDRIVSGLFSVAVTMGTIPIIRCPKDGAAAMIAAKLDRKLRDHILNAKDNLFSGKSAAAGATSSRPVLIIVDRNVDLVPMLSHSWTYQSLIHDVLSMHLNRITVETPVDEAGAAGGVVKKSYDLAANDFFWNKNSGAPFPQVAEDIDAELTRYKEDSTEITKKTGASSIEDLQNDTSASAQHLKAAITLLPELRERKSLLDMHMNIATALLKGIKDRQLDNFYQLEEDIKKQTKAQMLELLNDADKGNEPQDKLRLFIIWFLSTEAELSRADVEHFETVLKKIGVDTLPLTYIRRVREITRMTMISSAPTQQPQQTSASADLFRGFSSISSRLTDRFKDAGLGANFDNLISGVKNFLPANKDLTLTKITESLMDPQNASTSALQKTEGFLYFDPRSANARGTMPPSAKDARSGTQEKRGIDPSFGQRRQGFSEAIVFTVGGGSMDEYGNLQEWAKRSVGAGGAVSRKRVVYGSTELVNAASFLQELSKLGRESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M3C3K3</accession>
    <name>M3C3K3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribose-phosphate diphosphokinase</fullName>
            <ecNumber evidence="4">2.7.6.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SEPMUDRAFT_148422</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="4"/>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762962.1">
        <property type="nucleotide sequence ID" value="XM_016904918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C3K3"/>
    <dbReference type="STRING" id="692275.M3C3K3"/>
    <dbReference type="GeneID" id="27902055"/>
    <dbReference type="eggNOG" id="KOG1448">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033546_0_1_1"/>
    <dbReference type="OMA" id="MMLVGDI"/>
    <dbReference type="OrthoDB" id="413572at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097268">
        <property type="term" value="C:cytoophidium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000005">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000014">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF36">
        <property type="entry name" value="RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="14">
        <location>
            <begin position="5"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="124"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="174"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMF14841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="466" mass="50428" checksum="F37CA4CFF6E462FF" modified="2013-05-01" version="1">MVRNMLLFAGSSHPQLVEAICNHLGIPPANVELSKFSVGETRVEIGESVRGKDVYIVQTACSRPPSANYKGATTLNDGLMELLITISACKTASAKRVTAVLPLFPYSRQSDLPYNKVGAPLARMPAKTDEKGSGKYTFESRPPTPGGGSRYRDEKLEKQLNGLKLNGDLHLPSRKNTLESNTSDTSPPVANGAPTSSPSPVANHSNTGRESSTAHPPDFKPQRGYKQWVAQAGTLVADLLTCAGTDHVITMDLHDAQYQGFFDIPVDNLYGRHLLRRYITHQILPQHGGVDDCVIVSPDAGGAKRATSIADSLGMEFALIHKERRKKDVPSSAAPESGNSALLLVGNVKGKVCIMVDDLADTSNTITRAAKLLKRTGASKVFALVTHGVLSGDGVERIFHSGLDKVVVTNTVPQDEHVRQMKELAEKWGRPEDENKLEVLEVGGVFAEAIRRVHHGESISTLFQYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M3C6H6</accession>
    <name>M3C6H6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_147621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763972.1">
        <property type="nucleotide sequence ID" value="XM_016904420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C6H6"/>
    <dbReference type="STRING" id="692275.M3C6H6"/>
    <dbReference type="GeneID" id="27901557"/>
    <dbReference type="eggNOG" id="ENOG502S49J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007263_2_0_1"/>
    <dbReference type="OMA" id="DVPYIPR"/>
    <dbReference type="OrthoDB" id="5591786at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014839">
        <property type="entry name" value="Crt10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08728">
        <property type="entry name" value="CRT10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF15851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="664" mass="73807" checksum="0A3B6D4E83E361D2" modified="2013-05-01" version="1">MGKRGFAEAMVASTGYQNYKDRFGTRQRGNDCLESPPTAHWRCNLTAFSQKQNLYFVAYGSDIYVYVPQYPTQALPHAPALIVPSQPSRPGLRGTLDPRHPHYINVIVVERLGNEEVVAAVRDDGDVSVWLVRHVMHAVARRAEVGSSLSPVAEEVKAIFQANVGQSAWGLAIHAEARLIAVSANTHRISLFRFGLARESKTNREVTSNDDAASSTCQDRTVDVTLEVFNGSSNIPHVAFCNTGDDPQGRWLLTTDIGGNCRAIDLDVMQTYQTFRFAPVSNYLESHDRFNAGWGIFFLDRRSFIPEDSMNAALGLEKGERLPGEQVPGLYGNPPFWDISATVSHVPRCAAKFSASRRCGRRSRERRSTSIASAGTSSQLAREAASSPDNAAVSASDNTMMEAENDDVDPEIHDDNSDDYDYSDYDSDDFRTYTVGFASDDESDDHVYGRSMYDNNPRVAYPRRSVCEGLPCPILHASVRSVYLLQPPSNQTPTVGFNNALQQLVPAEHGWLNAFERLNMHCYIPAIGIVVLASQKGRVMILSLSRFLKRTTLPSSLSSSSPVTMGEDFAKKGHSMYQVRRQTVYAMRIEHILPFDEQEQQMHRPFQPLHGIATSPVQQGTALLPEDQCRWRLMLMYADHSILSYEISRKGSHDSAVDIGSVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M3C760</accession>
    <name>M3C760_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_131637</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF16091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764212.1">
        <property type="nucleotide sequence ID" value="XM_016902438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C760"/>
    <dbReference type="STRING" id="692275.M3C760"/>
    <dbReference type="GeneID" id="27899575"/>
    <dbReference type="eggNOG" id="ENOG502SSCR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044612_0_0_1"/>
    <dbReference type="OMA" id="TEINIQW"/>
    <dbReference type="OrthoDB" id="10029320at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050665">
        <property type="entry name" value="Cytochrome_P450_Monooxygen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24282">
        <property type="entry name" value="CYTOCHROME P450 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24282:SF211">
        <property type="entry name" value="CYTOCHROME P450-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF16091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="478" mass="53466" checksum="7446465DE5077CC9" modified="2013-05-01" version="1">MIGVMQFVIAGVILLVITALGLWRTLAVWNRREPCACQRRNTRRGDSSGCQQIIRAEVLDSSTTDVAQQGPSRRRLKNGLDPRESRAIPNKRLVHAFGINNCFTTAEKQRCAAFKALATKLVILDEEEWIWLADEVDGVCKRHLRSQTKQKLSSLIQLVTMKSILGPLCGFDSSRTDVDAELQVLASEINHQWLRSKEGLTEENKFANQPRLRQALAVIAPAWDGRDETENPLNLILPGYETLWRVVLRGFLEVVFRAKEPDRANWGRALQDFVVDPSLDQLDTGLPQYGGVSVHMIVKEALRLYPPTRRIYRAYQVGAAEPFEASADIEALHRDVATWGVNALKFDPTRWLGNCDHACFRKDNFMPFGNQPFVCVARGRGVKEGEKCLPFGVSMIAVILGGLVAAAGDNTKLVCAGSEWKTDEPLKTGREDYYAENLEVTGSTLVFLHGASGEMTWFRDMKPSNEAARIDYRIAVPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M3CDZ7</accession>
    <name>M3CDZ7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Pre-RNA splicing factor Slt11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_150233</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in pre-mRNA splicing. Facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome. Binds to RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLT11 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759377.1">
        <property type="nucleotide sequence ID" value="XM_016906036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CDZ7"/>
    <dbReference type="STRING" id="692275.M3CDZ7"/>
    <dbReference type="GeneID" id="27903173"/>
    <dbReference type="eggNOG" id="KOG0153">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027112_1_0_1"/>
    <dbReference type="OMA" id="CPLRVQW"/>
    <dbReference type="OrthoDB" id="10259600at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036002">
        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12265">
        <property type="entry name" value="RRM_SLT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000396">
        <property type="entry name" value="Putative Pre-mRNA-splicing factor slt11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034356">
        <property type="entry name" value="Slt11_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048995">
        <property type="entry name" value="STL11/RBM22-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF6">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21369">
        <property type="entry name" value="STL11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="251"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="172"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="323"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="205"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="325"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF11256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="396" mass="42748" checksum="60522F8ABF3D0ABA" modified="2013-05-01" version="1">MPPQIKQDLNRSGWETTDLPSVCEKCLSDNPYVQMLKEDYGEACKLCTRPFTVFRWKADRTARQKRTAICLTCARLKNCCQCCMLDLSFGLPITIRDAALKMVAPGPQSEINREYFAQNHEKEIEEGRGLEGYSKTEEKGRELLRRLANSEPYYKKQRRLELEAQEEGGQKLLEGGEGHKTGPIRTQDSKGKSAYGSAYGPSTTRGGGAAGGRGGRGGGRGGGRGGKGFPSGAALPPKPQDIAPPADKNITSLFVTGVEDDLPEHAIREIFSQHGALRSLVCSHRSHCAFVNYMDREGAEKAAQAFQGRAVVKGVPLRVQWGKPKPLDSMERDQRMENARAGRRTASATQALAGPAGRKAIAGAAENAPGDDFDSLAAVAPPPGQGDVEYASLAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M3CGV6</accession>
    <name>M3CGV6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Stomatin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_149547</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF13048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761169.1">
        <property type="nucleotide sequence ID" value="XM_016905623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CGV6"/>
    <dbReference type="STRING" id="692275.M3CGV6"/>
    <dbReference type="GeneID" id="27902760"/>
    <dbReference type="eggNOG" id="KOG2621">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024949_4_0_1"/>
    <dbReference type="OMA" id="KFGRFER"/>
    <dbReference type="OrthoDB" id="2105077at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd13437">
        <property type="entry name" value="SPFH_alloslipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000004">
        <property type="entry name" value="Putative membrane protease family, stomatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264:SF19">
        <property type="entry name" value="AT06885P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="BAND 7 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="3">
        <location>
            <begin position="84"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF13048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="358" mass="38815" checksum="62418D52F9BA7833" modified="2013-05-01" version="1">MDRAAAEVNGKAPLHGSGASPHDTDPIVKVQPPRREDLQTSYAQIIKADTEDDSQHGWYGGMVNTLGSIIGAIGAIPCCIVCPNPYKPVAQGNVGLVTKFGRFARAVDPGLVKINPLSEALIQVDVKIQIVEVPKQVCMTKDNVNLTLTSVIYYRITSPHKAAFGISNLRTALVERTQTTLRHVIGARVLQDVIERREEIAQSIREIIDETATGWGAEVESMLIKDIIFSQELQDSLSMAAQSKRTGEAKVISARAEVESAKLMRQAADILSSAPAMQIRYLEAMQTMAKTANSKVIFLPAQNQTVQSQLAMAEQYGEGPSSYRDYGTTNNGNAGSNEFSGNTHGFQSAVNARVVENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M3CH36</accession>
    <name>M3CH36_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Inactive metallocarboxypeptidase ECM14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Inactive metallocarboxypeptidase ecm14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">SEPMUDRAFT_148509</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Inactive carboxypeptidase that may play a role in cell wall organization and biogenesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761249.1">
        <property type="nucleotide sequence ID" value="XM_016904966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CH36"/>
    <dbReference type="STRING" id="692275.M3CH36"/>
    <dbReference type="GeneID" id="27902103"/>
    <dbReference type="eggNOG" id="KOG2650">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019326_1_0_1"/>
    <dbReference type="OMA" id="WFYHQLH"/>
    <dbReference type="OrthoDB" id="3626597at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03860">
        <property type="entry name" value="M14_CP_A-B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000060">
        <property type="entry name" value="Putative metallocarboxypeptidase ecm14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057246">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057247">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF147">
        <property type="entry name" value="INACTIVE METALLOCARBOXYPEPTIDASE ECM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00133">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 17" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0926">Vacuole</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032386" description="Inactive metallocarboxypeptidase ECM14" evidence="17">
        <location>
            <begin position="18"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="18">
        <location>
            <begin position="193"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="529"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="555"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="589"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00026187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EMF13128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="601" mass="68094" checksum="BC39B070F2374C1E" modified="2013-05-01" version="1">MKYHSTAILALCALALAAPPTRHHALEPPRQSRWATIKHHFLQSVLGFEQRRHEHITLAKDTAFDRHVPARTLATYGGDLVLRFNLSTAQESASLAEAADTLMLDVWEFAHDWVDIRLSKDSVPLLLGLLPASLQHAHKPLLREKELSDAIIANYQKSAHHDTTAAHASPTRRPFNADLAQTSEPEANLFFADYQPLNVIDPWLRLMASLFTTHVRLLSIGLSYEGRNIPALRVGVHPSMDDDPNPPQRKTILIVGSLHAREWISTTTVNYIAYSLITGYGKDHSITEMLESFDFVFVPILNPDGYVYTWETDRLWRKNRQKTGIRFCQGMDLDRSFGFEWSATDNPCSESYTGEAPFQAVEAKRLADWAKNETQNNNVDFVGFLDLHSYSQEVLYPYSYSCDDAPPGLENLEELAMGLSKSIRTTHGRNYEVMSACEGNSVYTSGNKKVHLRPSIEPNGGSALDFFYRTVGVRYAYQLKLRDRGTYGFLLPKEHIVPTGKEILNAVLYFTSFLNDLYNMSGGEKPAAKLNAEDSEVDTKPEKLRNGAMSHPQKEDEEKEDEEQEEDEQEDEDGEEADPWVIVEDLEVEQAKPDLKRPRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M3CHM8</accession>
    <name>M3CHM8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">SNARE complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_148641</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761414.1">
        <property type="nucleotide sequence ID" value="XM_016905050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CHM8"/>
    <dbReference type="STRING" id="692275.M3CHM8"/>
    <dbReference type="GeneID" id="27902187"/>
    <dbReference type="eggNOG" id="KOG0809">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038177_0_0_1"/>
    <dbReference type="OMA" id="NRKMCII"/>
    <dbReference type="OrthoDB" id="10251371at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15845">
        <property type="entry name" value="SNARE_syntaxin16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.70:FF:000021">
        <property type="entry name" value="SNARE complex subunit (Tlg2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006012">
        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF83">
        <property type="entry name" value="SYNTAXIN-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00914">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="322"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="248"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="344"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="393"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF13293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="405" mass="45547" checksum="7526117B9D69AF6F" modified="2013-05-01" version="1">MSSAVNLGAWRDRTNLFISYRQSYTHHPAKRSRITGSGNARFVDTPNDSEREGLMSHLDHDGDAVIEMDILPPRWLDIQDEVSQTLSEITGKVKRLDQMHAKHVLPGFDDESVKAKEERDIENLTQDITKDFIMCRNAIRRIDRLQQEQHQSGGVISDADATMAQNLKMSLASRVGEVSTLFRKKQSAYLKKMRSLGGMNTLLDRAGTPMAQNPYNDPAMMDSETDRSAAQSTLLQTAQVRRRPGLMDAQIDQREREIEKIAQGVIDLSNLFQELNTMVIDQGTVLDRIDYNVERTAEHVKEAEKELKVATGYQKRSTKRKIILLLVLIVVGVFILLLIKPRRSSSFTPAPSVGAPKAPVPNDPGAGLPPRAHRRADAGTFTPGEAVAPRHSEWKRRRRRRPTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M3CJB5</accession>
    <name>M3CJB5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_149023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="5419666at2759"/>
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        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF13883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="267" mass="29056" checksum="498EE740F73551D5" modified="2013-05-01" version="1">MSLARAFTIKREKEQQPANLHVGRAASTRNGRPVKRSQISAPVALISSTNALSYDAPDLPTARRLHLRSVTGSSGTSTNSSSSDESDAPSLSFDGTDRDSIDDSPATPEPNHLSCYFKPAVDTKTPHRSPVISSHSSFDAPSIPQRVPSHSKKAHEFVHRKRSVQRLMSPPASQVQRNSSDFFSNWSQPVEAPPQETTPSSENPFGNELAQLDVVAEEMSHAVCDAAAQEDQHIMQTYGLALLGANDYTSEIGGLVHDYLLDEPVWI</sequence>
</entry>
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    <accession>M3CLB8</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016904808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CLB8"/>
    <dbReference type="GeneID" id="27901945"/>
    <dbReference type="HOGENOM" id="CLU_2470506_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF14588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="88" mass="10269" checksum="B2D334C777C6E9C1" modified="2013-05-01" version="1">MGCANGAIFDCFGHDHNCRRFQIDSERRETEGSETEAVEDGVMMMMTIMMSRRRGRGEEKEMFRSLFLLDDDDDVRDGPRPDEYRVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M3CN50</accession>
    <name>M3CN50_SPHMS</name>
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        <recommendedName>
            <fullName evidence="2">DUF7704 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_7601</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016910117.1"/>
    </dbReference>
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    <dbReference type="STRING" id="692275.M3CN50"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112091_2_1_1"/>
    <dbReference type="OMA" id="YTHSMAQ"/>
    <dbReference type="OrthoDB" id="8048523at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056121">
        <property type="entry name" value="DUF7704"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37019">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37019:SF1">
        <property type="entry name" value="EXPERA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24803">
        <property type="entry name" value="DUF7704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7704" evidence="2">
        <location>
            <begin position="12"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF15223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="116" mass="12636" checksum="EE4A232F83EE2DCD" modified="2013-05-01" version="1" fragment="single">MAPTAAITKASNVLPSYYRFLLMNVESLFAFGGVIMVLVAPGHYVTALTRESVASIDSATDFVYTQLGGGWMVIVFIEAVIMRLVDDIKVWKLLCMAILLSDALYTHSMAQAVGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M3CPG3</accession>
    <name>M3CPG3_SPHMS</name>
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        <recommendedName>
            <fullName evidence="4">GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_139323</name>
    </gene>
    <organism evidence="6 7">
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        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the GSE complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
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        <property type="protein sequence ID" value="EMF15638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763759.1">
        <property type="nucleotide sequence ID" value="XM_016902900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CPG3"/>
    <dbReference type="STRING" id="692275.M3CPG3"/>
    <dbReference type="GeneID" id="27900037"/>
    <dbReference type="eggNOG" id="KOG3887">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047421_2_0_1"/>
    <dbReference type="OMA" id="HEIFEVR"/>
    <dbReference type="OrthoDB" id="26136at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990131">
        <property type="term" value="C:Gtr1-Gtr2 GTPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF2">
        <property type="entry name" value="GH16429P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="199"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="203"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF15638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="287" mass="32881" checksum="500C548B0A473DEA" modified="2013-05-01" version="1">MESFMKFESLEVPPHMQLISPDFDREAVFGNAGAIIWVIDMQDEYFQSIDQLIKTAGFVMDNYPRINFEVFIHKTDGLSEEYKYGTFRDVRQRVQDELSDAGYANRPVAFYLTSIFDHSIYEAMSKVVQKLLPQLPAMESLLNKLCSACRIQKAYLFDTVSKIYMATDTSPTFLKDYEVCADYVDVIVDIKQIYGWQSGSRSNTRETHPPDESNHNNKNNSNTTSEAVGESLITYDKSGDTYIYAREINDYLSLICVMGQGSTAQKRVLIDYNVSILHDALQQMFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M3CQH2</accession>
    <name>M3CQH2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase family 8 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_147661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764044.1">
        <property type="nucleotide sequence ID" value="XM_016904444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CQH2"/>
    <dbReference type="STRING" id="692275.M3CQH2"/>
    <dbReference type="GeneID" id="27901581"/>
    <dbReference type="eggNOG" id="KOG1950">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051232_0_0_1"/>
    <dbReference type="OMA" id="AFLNWQF"/>
    <dbReference type="OrthoDB" id="2014201at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF15923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="428" mass="48907" checksum="238EEE1A9FEF0A7F" modified="2013-05-01" version="1">MAPLVRNICFLIGAVVILAVLYSSTSISGATTRWTNPALGGASAANPPSAVLGVPDDSIVKSDGDNKVDETVQPAPERKEGDKKDEEKEEKKEKGGMEKALEDSKATKTEFNEVKYAFQYDLDQYAMPTYNARDLRRYMPVNWQGPGRHAFCTYYSTRNATLHDPYFLAALSLTYRLLWDPASKSDKYPLVVFVAPFTPDEHRHMLEAAGAIVRELDLIEYHPDKATFSRWRDLFSKINMWRQTDFELLAFLDLDAFPVQNIDGIFHIADRQRCKPELLPKEDKLHEKEICDYVFSGTSVGGGYKEINVGVVVFNPNEAMRNRLLRESLHTDKWDNFMAEQAFLSYAFSGDGPFPASEVDREWNGFFPQDDEGPKTGKLKIIHEKLWAENDHLTWAKNWFSNEWKAMLKMFNSKKFVQARESAGRRPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M3CW03</accession>
    <name>M3CW03_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_24013</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756438.1">
        <property type="nucleotide sequence ID" value="XM_016908378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CW03"/>
    <dbReference type="GeneID" id="27905515"/>
    <dbReference type="eggNOG" id="ENOG502SU9X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_145544_2_1_1"/>
    <dbReference type="OMA" id="ITELWNR"/>
    <dbReference type="OrthoDB" id="1612078at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF08317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="75" mass="8843" checksum="FBDBD5CFBB37F2ED" modified="2013-05-01" version="1" fragment="single">NYQRALDIARNSEGDLDPSVSAYLEDALTDIWRRLMIQPDDYIMTKDEFAVFNFYRGRFDDNEVAENAVARYWAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M3CX31</accession>
    <name>M3CX31_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_151659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756798.1">
        <property type="nucleotide sequence ID" value="XM_016906963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CX31"/>
    <dbReference type="GeneID" id="27904100"/>
    <dbReference type="eggNOG" id="ENOG502TBUC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1305538_0_0_1"/>
    <dbReference type="OrthoDB" id="3650120at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032671" description="Ig-like domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF08677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="23847" checksum="425EBE68E7F302A7" modified="2013-05-01" version="1">MHFFSFSLPTSLVATILAIATAPSECRSIIPSQRSSRLLFDESNYQQQQQRQQQEQKQQLLKIDSLSSSPEYTLEPQHVTATGQHFDVQENSIGVLFTRPTNIATDARAVAYQIETLHLWLPLGKKVFTRDSPLLPLHPLSARITTLITSTPEPAAPQQIEKIECCLYGASSGSDAEEEDSSKVRFSWKDNLVYFPPSRKEIESYECYVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M3D078</accession>
    <name>M3D078_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin cytoskeleton-regulatory complex protein PAN1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Actin cytoskeleton-regulatory complex protein pan1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">SEPMUDRAFT_150992</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the PAN1 actin cytoskeleton-regulatory complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Actin patch</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PAN1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF09888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758009.1">
        <property type="nucleotide sequence ID" value="XM_016906529.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.M3D078"/>
    <dbReference type="GeneID" id="27903666"/>
    <dbReference type="eggNOG" id="KOG0998">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001963_1_0_1"/>
    <dbReference type="OMA" id="GMPGQWG"/>
    <dbReference type="OrthoDB" id="2015333at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
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    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
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    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="172"/>
            <end position="260"/>
        </location>
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            <begin position="468"/>
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    <feature type="region of interest" description="Disordered" evidence="18">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    <sequence length="1414" mass="153138" checksum="D732AECE62B012F3" modified="2013-05-01" version="1">MFSASNMYLGGGNSARGGPQQQQQQQPPQGAFGQAPLQQQYTGYPVGGLQPQATGFPQQQPQQQQYGAFQQLPPAPTGYQQPQPTGFQQQQQQPQQQQQQLPQINMQQTGFQQPQQTGFQPPQPMRPQATGLTSNDMANSFRASSSQAPPPVPAKTGSKIPNIRLSFITAQDQAKFEQLFKSATGGSQALSGDKARDILLRSKLDGNDLAQIWTLSDTTKSGQLLFPEFALSMYLCNIALTGKALPSSLPEKVRNEVSSMVDIISFNVDDTPGAAGRNEPPTIQQPQAQNPSNQQLLTQLTAQPTGFQVPQATGYQQQLQPQATGYMPQAQGYTGPRPPMPPMPTGFGNNLAPGLSAQPTGLLPQQTGYPMAQPLNAQPTGRPGQWGLVNAPAAGLPNLQALQSQMMPQPGREAGFSAQGLRGNATVPWAVTKDEKKIYDDMFKAWDGFGKGYISGAQSLEIFGQSGLNKQDLERIWTLSDPHNKGRLNLDEFAVAMHLIYRALNGYPVPNQLPPELIPPSTRNINSSIDAMKGLLGRDAEERKSSGAFLQPQKTGVSYLKGHSFRANGAAGARKDATVFKNNDDDVGYRSSARRRIGQHGRDSSPATSDTSSVPADEMSIDQLKKTIREKQVLLDAMDFEDEGNAEQEDALDRKDRKEAEELFRRIRRIQEDLDTHPNSAFKTGDSDAERRALQRQLRGLQDRLPELASHVRRCERAIADAQLELFRLKDAKANPGSAPAIVGTGPGGAVTESDRLKARAKAMMQQRSAALSGKKVEPADDGRGAAARLEEENTRITREREDNEKMVRDVEESVTEYSKGLESSLKEGAESASDEHERRRWEDGLGVEDEVKDFIFDLQRSSRAARVRNEDKSQSISNPVEDDGRTSTPSTRTDSPASSRQPAASSPAPSGSSYSSYKTAEERAAFIKQQAEQRMAERLAALGLKAPSKSSAESPAQRAERERKERDDKLRRAEEEDARREQERQARISGETISPPSPAASKSKPPPPAPRKNRSESLQSDTQSKSEAKAAEQQIKEQALKEQEAALATETREMEDEEARQERELQQQKEEAAASLRALEEQVKAGKAKRSEEKKRREAAKKEAQEKEARLAAQRAEIEAAKERERELRLQLENMDDDSSSDDEDKNTPTESTPAQSMELPQVQETPASPPPAPPLPSAVAPPAPPMPGSAVTSPPEQSKNPFFRSMNQQSSAASTPAITSPDAGPKVDTNPFHRLTQQDLAKQQQALPDPAPAPSRSRSKPADEDDWSVLDSSDDESDEEDKPQGGSAKQLASILFGTMAPPRPLSAMDSPKSSGSPAPNGTDRFASPPPAPPMPGSDAPPPPPPPPMPSAGAPPPPPGPPPAPAMPGGFPSGAPAAAPDRSGLLQAIQLGKGLKKVETKDRSTAATAGRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M3D2P8</accession>
    <name>M3D2P8_SPHMS</name>
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        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_118711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_016901451.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="27898588"/>
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    </dbReference>
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    <dbReference type="OMA" id="PHEVEIQ"/>
    <dbReference type="OrthoDB" id="5275938at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
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        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
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        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="41"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
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        </source>
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        <source>
            <dbReference type="EMBL" id="EMF11417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="413" mass="46452" checksum="18085A428A020F26" modified="2013-05-01" version="1">MADTTKVIVPPEDDVDLYADNAIALRNFFDKQNEHCICDSGDIVLVVNDGFHPIQKLRVSSHVLAMSSRVFEVLFSGRFAESLAAKDRSSSEPHEVEIQDAPVPMRQLCRLLHHQEIFATGDKSAKALLDLAIVIDKYDCCLTLHLQADALLQHATDSHFDEAISHAQESYGLQRLVTAAYMLDRPLHFRRLSSQLVLQTTMIQAKSFEARCLDILPESFVGSLFNQQNVAQQELSRQVARLVMEFKEAARAASRESLVVDFLDNLGRASGLWLPDTKRPLSSQLDGLRETELPVVPLPDGAEMSNPNRSGNEYPSLMAAGGWLTFDHKQLRGPTEKSLRERAASVREICVGVCLDCIKHRECRKSHRHLWKYSESDSCFPYGSHPDAESTCIGGRPDFVHSIEYPGYWEKCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M3D3H2</accession>
    <name>M3D3H2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-gulonate 3-dehydrogenase</fullName>
            <ecNumber evidence="8">1.1.1.45</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">L-gulonate 3-dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_149332</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.45" evidence="8"/>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760896.1">
        <property type="nucleotide sequence ID" value="XM_016905495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D3H2"/>
    <dbReference type="STRING" id="692275.M3D3H2"/>
    <dbReference type="GeneID" id="27902632"/>
    <dbReference type="eggNOG" id="KOG2305">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_0_1_1"/>
    <dbReference type="OMA" id="ALRWSFM"/>
    <dbReference type="OrthoDB" id="2021159at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050104">
        <property type="term" value="F:L-gulonate 3-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006180">
        <property type="entry name" value="3-OHacyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075:SF1">
        <property type="entry name" value="LAMBDA-CRYSTALLIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00067">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="12">
        <location>
            <begin position="7"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="11">
        <location>
            <begin position="183"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="10">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF12775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="308" mass="33790" checksum="706CE07CDABACE7C" modified="2013-05-01" version="1">MAAKPTKIAVIGSGTIGLSFAALHLSRNTSCTVVIFDSRPDLQEYVSNNISGYLVDTDQISCIERISFAKTIEEAVEKADIVQEQGPETADFKIGIWPEIEKHAPKEALFWSSTSGIPASDQSRDMMDKSRLVVVHPYNPPHIMPLLEVVRSPATSDDVIERTLKYWRDIGRTPVEVKKECVGFVANRLAFALLREASSLVSQGVVGVEELDDIVCASMGPRWTVAGPFKSYHAGGGEGGLKSFMEKIGGTIQNCWDASDEDIRKGNIRVGESWQADICRQAAAAYGMADTAERDRKTKNVLDVVQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>M3D4T2</accession>
    <name>M3D4T2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">P-type Ca(2+) transporter</fullName>
            <ecNumber evidence="2">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SEPMUDRAFT_86256</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="2"/>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760995.1">
        <property type="nucleotide sequence ID" value="XM_016910408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D4T2"/>
    <dbReference type="STRING" id="692275.M3D4T2"/>
    <dbReference type="GeneID" id="27907545"/>
    <dbReference type="eggNOG" id="KOG0202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_3_3_1"/>
    <dbReference type="OMA" id="KMHACET"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140613">
        <property type="term" value="F:P-type manganese transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000040">
        <property type="entry name" value="Calcium-transporting ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000028">
        <property type="entry name" value="Calcium-transporting P-type ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="363"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="900"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="940"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="988"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1020"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="15">
        <location>
            <begin position="56"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="620"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="184"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="624"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMF12874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1062" mass="113472" checksum="7E37522DCF12ABF7" modified="2013-05-01" version="1">MSRSSPPIIPLQHASRTSPSPQQQSLAAPPTSTAASAHTRNSSRIKLPGQQSVTSQHAVLTVEQVAERHSTSLTNGLHPSDASTRLHVQGPNELPGEEPEPLWLRFAKQFKETLILLLLASAAISAVMGNFEDAVSIAIAVTIVVSVAFVQEYRSEKSLEALNQLVPHYAHVIRGISTSAVSTENKESGDSDSEEKATRASTTISASQLVTGDLVLFHTGDRIPADIRITHAADLSIDESNLTGENEPVGKTADTLGPVAYANGSTDPSTILRGGEIRLTDQTNIAFQGTLVRSGYGQGIVVSTGGDTEFGAISASLAEIESPRTPLQESMDRLGKELSYMSFGVITLIMLVGLWRGRKFLELFQIGVSLAVAAIPEGLPIIVTVTLALGVLRMSRRNAIVRRLPSVETLGSVNVVCSDKTGTLTQNHMTATRMWSFGDGRPQEVAKVITDAPNAATTQAVLRAANIVNNGRLNTHTHGQITAASAAVLASTGGQDDLANAKSRWAGQPTDVALLDMLDNFHEDDVRARLGERKHEVPFSSERKWMGVILEGSNGDTTAYIKGALERVIDRCDTYISSQGEVVLDEKRKQEVDAAAREMAEEGLRVLAFASGPVRLRGLRNASRDVSASSRSSTPASTRGGKQQPAPNGEDIFSGLCFGGLVGMSDPPRKGVDRSIRRLMAGGVKVIMITGDAETTAVAIARKLGMPINLNSAIGSPVLRGDQIDHMSEAELAEAMSRISIFARTSPEHKLKIISALQSRGDVVAMTGDGVNDAPALKKADIGISMGKLGTDVAKEAADMILTDDDFSTILNAIEEGKGIFYNIQNFITFQLSTSIAALGLVMLSSLGGWKNPLNAMQILWINIIMDGPPAQSLGVEPVDPALLSQPPRPRDARVLTPRLIRRVLQSAVIIILGTLITYVSNLTPEDLAAHSVSARDTTLTFTQFVLFDMFNALACRSATRSVLRGEVPLLPAHWLGKSNTAAGQEGNVMFTYAVFGSLLGQGLVIYFPPLQSVFQTEALSLGDLFKLVALASTVLWVDEGRKFYERRKAGGSIGGRAGRMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M3D4U3</accession>
    <name>M3D4U3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD-dependent protein deacetylase</fullName>
            <ecNumber evidence="6">2.3.1.286</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_149427</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(6)-acetyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-acetyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:43636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="ChEBI" id="CHEBI:83767"/>
            <dbReference type="EC" id="2.3.1.286"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.286" evidence="6"/>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761005.1">
        <property type="nucleotide sequence ID" value="XM_016905541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D4U3"/>
    <dbReference type="STRING" id="692275.M3D4U3"/>
    <dbReference type="GeneID" id="27902678"/>
    <dbReference type="eggNOG" id="KOG2682">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023643_0_0_1"/>
    <dbReference type="OMA" id="ATHSCID"/>
    <dbReference type="OrthoDB" id="420264at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01408">
        <property type="entry name" value="SIRT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017328">
        <property type="entry name" value="Sirtuin_class_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF6">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037938">
        <property type="entry name" value="SIR2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6 8" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 6 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="12">
        <location>
            <begin position="16"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="292"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="332"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="302"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="332"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="396"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 10">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="44"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="54"/>
            <end position="56"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="218"/>
            <end position="219"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="242"/>
            <end position="244"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR037938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037938-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037938-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037938-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF12884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="406" mass="44394" checksum="15C3C1D65464394D" modified="2013-05-01" version="1">MGNEESTPIDESTPPSTLTGRTVEAVAEYITSGKVKKVVVMTGAGISTSAGIPDFRSPETGLYANLARLNLPYAEAVFDISYFRQNPEPFYALAHELYPGKYRPTITHAFISLLHHKGILLKCFTQNIDCLEQEAGVPEEKMIAAHGSFAQQSCIECKTPYPSADIKKHVENKTIPHCYDCKGLVKPEIVFFGEQLPAAFFEARDLPAEADLAIVMGTSLTVQPFASLPGFTREETPRLLINKERVGNLGTRADDVLLLEDCDTGVKKLAKACGWLEELEALWATTGTTTKADNEALLPEATQEKENEKKKREKTRDEQIEDEVAQLTKEVEDTLHLSRSHTEKVKNERLPGEEKAHPPKSDSAQDGGLDHVFVGGISGGVAAAPKIDGTGTVGKTEAEEKEESKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M3D4V8</accession>
    <name>M3D4V8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cwf15/Cwc15 cell cycle control protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_148603</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC15 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761361.1">
        <property type="nucleotide sequence ID" value="XM_016905024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D4V8"/>
    <dbReference type="STRING" id="692275.M3D4V8"/>
    <dbReference type="GeneID" id="27902161"/>
    <dbReference type="eggNOG" id="KOG3228">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068312_0_1_1"/>
    <dbReference type="OMA" id="KYREHGQ"/>
    <dbReference type="OrthoDB" id="30179at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006973">
        <property type="entry name" value="Cwf_Cwc_15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12718">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12718:SF2">
        <property type="entry name" value="SPLICEOSOME-ASSOCIATED PROTEIN CWC15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04889">
        <property type="entry name" value="Cwf_Cwc_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="64"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="140"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="155"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF13240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="251" mass="28641" checksum="83A1B1D03F8F13D4" modified="2013-05-01" version="1">MTTAHRPTFDPARGKEAARGEAYHQRLLPAHKTLKFRQPNQGTPAEQAKRDLKAELLRNEAKYYAKKEGREITDDDDEDAIPQLQIEAGGVKRKATDASDVGGEAAGEEQEDYEAKKRRVLEETRDIDADSESGGSSDSDSGDDDEDEEEDETAELMRELAKIKAERAEKAAKEAAEQAKKDEEQREKDIALGNPLLNEGRVQYDVKRRWDDDVVFKNQARGTEERGKEKRFVNDLLRSDFHRRFMDKYVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>M3D559</accession>
    <name>M3D559_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidylinositol 3-kinase VPS34</fullName>
            <ecNumber evidence="7">2.7.1.137</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_140767</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12709"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.137"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:12710"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.137" evidence="7"/>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761441.1">
        <property type="nucleotide sequence ID" value="XM_016902943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D559"/>
    <dbReference type="STRING" id="692275.M3D559"/>
    <dbReference type="GeneID" id="27900080"/>
    <dbReference type="eggNOG" id="KOG0906">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004869_0_0_1"/>
    <dbReference type="OMA" id="LHKFAQY"/>
    <dbReference type="OrthoDB" id="67688at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071561">
        <property type="term" value="C:nucleus-vacuole junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016303">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032120">
        <property type="term" value="P:ascospore-type prospore membrane formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051365">
        <property type="term" value="P:cellular response to potassium ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000425">
        <property type="term" value="P:pexophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd08397">
        <property type="entry name" value="C2_PI3K_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00870">
        <property type="entry name" value="PI3Ka_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00896">
        <property type="entry name" value="PI3Kc_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000002">
        <property type="entry name" value="Phosphatidylinositol 3-kinase catalytic subunit type 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000002">
        <property type="entry name" value="Phosphatidylinositol 3-kinase catalytic subunit type 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.70:FF:000009">
        <property type="entry name" value="Phosphatidylinositol 3-kinase VPS34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057756">
        <property type="entry name" value="PI3-kinase_type3/VPS34_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002420">
        <property type="entry name" value="PI3K-type_C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008290">
        <property type="entry name" value="PI3K_Vps34"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF7">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00792">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000587">
        <property type="entry name" value="PI3K_Vps34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00142">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51547">
        <property type="entry name" value="C2_PI3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="C2 PI3K-type" evidence="11">
        <location>
            <begin position="25"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="PIK helical" evidence="10">
        <location>
            <begin position="367"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="9">
        <location>
            <begin position="633"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="231"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF13320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="924" mass="104555" checksum="167D48FADEA05952" modified="2013-05-01" version="1">MEPFTFASSSELHMPVGVKVNRLEGYEKPLPYSTLLKRPDLRHRGSNLTANSELYITVTPFADSKPLTVPAQTPYKHFRNGRVWNQWLSLPIDYSSLPANTQLAITLWDLSPINPSGGDKSHHIPFGGTTIPLFDDDATLRTGRQKCKIWRHKAADGFSDTTTRFDEPRKRGRRNQPAEPIVVDEKLSRRDAELERLVSLMKKHEMGEISESRWLDQMVFRQVEKLERQQIKDSIKSRRPALPVNGDTSGEHSEMQCADGDPDHVDGTFFLYIEFPRFDHPIVFTDHEYPPPPVSSIPAPHPLSTPGVNFKPPPEVQLGPGIHSDGLNDTDGGGRLIGIYDPEVGYADNPAETKHRRLVRGQQHALDRDLRPNPKMRDFLNRVMMYGPTVDLSDKEKDEVWRFRHHLTRDKRALTKLVKSVNWNEPAESKQAIALLPKWVEIDIDDALELLGPGVRNPTVRAYAVDRLRKADDEELLLYLLQLVQALKFEPQHSREQDESDSSLASLLIARSAANLKLGNFLHWYLMVELDLGDEQAQSSANKKLFARVSFDFQKELETTAEGKARRRVLLRQGEFITVLSKISKDVQSQKGDRLRKIEHLKKMLADPRNELLHLDPPLPLPLDPEIKAVGIIPDNCNVFKSSLLPLLLNVKTDTGEVYPFMFKSGDDLRQDQLVIQIIALMDRLLRKENLDLKLTPYRTLATSRLAGAVQFIASTPISAILTNPKYNNSILGYLKAHNPPRSSSQSILGVRKDAMDNYVKSVAGYCVVTYLLGVGDRHLDNLLLTGDGHFLHIDFGYILGRDPKPMAPLMKLSREMIEGMGGSNNEQESQFESFKSYCFTAYTTLRRQSSLILNLFSLMQDAGIPGLAVFGDQAVRKVEERFKLDVSETDATRVFEEMINREIGAWGPVLIDKLHGYAQAWKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M3D5C2</accession>
    <name>M3D5C2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_125176</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the nitroreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761486.1">
        <property type="nucleotide sequence ID" value="XM_016901959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D5C2"/>
    <dbReference type="STRING" id="692275.M3D5C2"/>
    <dbReference type="GeneID" id="27899096"/>
    <dbReference type="eggNOG" id="ENOG502RYI9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073125_0_0_1"/>
    <dbReference type="OMA" id="YDIPANW"/>
    <dbReference type="OrthoDB" id="2138173at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02140">
        <property type="entry name" value="Frm2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.109.10:FF:000001">
        <property type="entry name" value="Nitroreductase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="entry name" value="NADH Oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033877">
        <property type="entry name" value="Frm2/Hbn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43035">
        <property type="entry name" value="FATTY ACID REPRESSION MUTANT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43035:SF1">
        <property type="entry name" value="FATTY ACID REPRESSION MUTANT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="FMN-dependent nitroreductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="8">
        <location>
            <begin position="110"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF13365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="305" mass="33788" checksum="C300E62D508F49D0" modified="2013-05-01" version="1">MRDRAAKSLGAVLALLAGLIAYLLILDPHGEDAMHRAAPLLTRLAPVSFFSQTNTISFASRVQKASSSAAAVPSSPSSIQYTPPPSSSRQYSSTTSTATMASKLTFSEAVKHRRTIYQLTKQSTISDDRIKEIATQAIKDVPSSFNSQSARLVVLVKEKHDEFWGIVENILKAVVPSEQWEHTASRLKGFQNAYGTILFYEDPEPIKALQSKYAIYADKFPQWSEHTTAMHQYELWTALEAEGLGCNLQHYNPLPDQKAAEAFNIPLDWSLKAQLVFGTPAEGAREGLAARSEEPIEKRLFFHGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M3D5X3</accession>
    <name>M3D5X3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">acetyl-CoA C-acyltransferase</fullName>
            <ecNumber evidence="11">2.3.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SEPMUDRAFT_148809</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21564"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.3.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.16" evidence="11"/>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761681.1">
        <property type="nucleotide sequence ID" value="XM_016905162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D5X3"/>
    <dbReference type="STRING" id="692275.M3D5X3"/>
    <dbReference type="GeneID" id="27902299"/>
    <dbReference type="eggNOG" id="KOG1389">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031026_1_1_1"/>
    <dbReference type="OMA" id="MTAFPEP"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050215">
        <property type="entry name" value="Thiolase-like_sf_Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853:SF8">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="15">
        <location>
            <begin position="37"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="16">
        <location>
            <begin position="299"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="13">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="377"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMF13560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="421" mass="43916" checksum="7972C9C3B8F0A6B1" modified="2013-05-01" version="1">MANQSTTHAAQVRVQQVVGHMQATGKAGLLEKHPDDVVVTSALRTAFTKGGRGGFKDTAGADLLYGAFTGLIERSGIDPSLVEDISVGCVLAPGGGATEFRAAALAAGFPDSTAVKSLNRQCSSGLQACVDIANAIKTGMIEIGVGAGVESMSSQYGPGAVTEFSELLEGHKKAAECKVPMGLLSENMAKDKGITRAAQDQFAAESYRKAGEANKAGLFKEEIYPLKVKWTDPKTDEEKEITVAADDGVRQVTAESLGKIKAAFSKDGSIHAGNASQISDGAAAVLLMKRSTAERLGQTILGKYVAASIVGVPPLLMGIGPWKAIPEALKKAGITKDEVDIYEINEAFASQCLWCANELGLPQEKINPKGGAIAFGHPLGCTGARQVSTLLYELKRTKKQVGLTSMCVGTGMGMAAVWVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M3D6Y5</accession>
    <name>M3D6Y5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_148873</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761760.1">
        <property type="nucleotide sequence ID" value="XM_016905196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D6Y5"/>
    <dbReference type="STRING" id="692275.M3D6Y5"/>
    <dbReference type="GeneID" id="27902333"/>
    <dbReference type="eggNOG" id="KOG0270">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023867_0_1_1"/>
    <dbReference type="OMA" id="CFVPRGV"/>
    <dbReference type="OrthoDB" id="270624at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000457">
        <property type="entry name" value="rRNA processing protein Pwp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044285">
        <property type="entry name" value="PWP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14091">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14091:SF0">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="275"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="411"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="50"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="513"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="62"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="521"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF13639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="548" mass="60646" checksum="ABB4B7269D397CD4" modified="2013-05-01" version="1">MSSMITSTAWVPRGHAAAYPTKYNMDDEEYARIAKLAKLELEDAKDDLEKARDSLNKVNMGEVDDADNGAEEEDSDNDDNDDDDNDDDLAKDDDLAEYDMEHYDDEPDMPEDEDEDAKTGGIFSNIKSLAYHADGEKDPYLTLPEGEVSDDEEREELQILPTDNMVLAARIEDEVAHLEVYVYEDEADNLYVHHDVMLPAVPLCVEWVGTKVGQGDVGEGGNFAAVGTMDPDIELWDLDVVDCMYPNAVLGQSSQPDAPDAAAKKKKKKSKKANEKYHVDAVLALAANRNHRNLLASASADKTVKLWDLNTCTAAHSYEHHTDKVCALAWHPTQSAILLSGAYDRTVVAADMRVKDGKVPRWGVESDVEQIQWDPHNENNFYVSTESGVLHCFDARQQPATPEKSKPIWRLQAHESELSTFSINPAVPGFIATGSTDKTVKLWNVTETGPSMVVSRELEVGKVFSANFAPDNEIAFRLAVAGSKGAVQVWDTSTNRAVREAFATRVKMPEGDVKERLVGIEQDDEIEEEEAEAEENGGEGGWESMDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>M3D6Z5</accession>
    <name>M3D6Z5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_107857</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762031.1">
        <property type="nucleotide sequence ID" value="XM_016900704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D6Z5"/>
    <dbReference type="GeneID" id="27897841"/>
    <dbReference type="HOGENOM" id="CLU_590742_0_0_1"/>
    <dbReference type="OrthoDB" id="10686366at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF13910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="463" mass="51460" checksum="1D5EC127F271236A" modified="2013-05-01" version="1">MSPEALFATVWFSPSTMKSKLRTKMGNCFSSSTKTKTESIFHIAPATMPKLAIPRDHPSHPDEETSPTPRRLAVEWDDGIERESSMKIKKRIARTRMRQVPEPLQSPLFDTPLRDSRSFSAYVWEQLERLDEACGGAGTISRITTADGSLGQRRRKGIRFEGVDSEGKSILTSSAEKPCIYGACFALSGDRGGKTGRAGIPERVDCEQISVNTIECTCSILRGPSKQPTSNHFIHYWPQAMVQAYAGVHPEVDIAVARNGNCHMICTNSLPYTPLYPHTWRYLRFYERENHPPATKATYSSLSTVPSLQAPTPLKFHSNPPTSRGSTTRLSRHVHSQSIPLYLPPALSCHQTAETQLTTTYCSSLQQMFCSIGHSGPHPGCHSQLLTYIQPCVPKSGKAPKKYHSTMCFPKVLTEVWGLPPQGCKLYCGVCKRSLNITGNEGDDVGKGWRAEKGRRGWMFKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M3D772</accession>
    <name>M3D772_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_31574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762131.1">
        <property type="nucleotide sequence ID" value="XM_016908472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D772"/>
    <dbReference type="STRING" id="692275.M3D772"/>
    <dbReference type="GeneID" id="27905609"/>
    <dbReference type="eggNOG" id="ENOG502SFZ8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_157438_2_1_1"/>
    <dbReference type="OMA" id="GSADKMQ"/>
    <dbReference type="OrthoDB" id="5239630at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019034">
        <property type="entry name" value="UPF0390"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09495">
        <property type="entry name" value="DUF2462"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF14010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="62" mass="6769" checksum="2CBAD205BA6F8039" modified="2013-05-01" version="1" fragment="single">PSNPNRKQLGARVIKPTKNSSALKTAQFKKKHSSGMTALTEKSLASRAGHLELLKGGKREKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M3D7C3</accession>
    <name>M3D7C3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_147907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762191.1">
        <property type="nucleotide sequence ID" value="XM_016904590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D7C3"/>
    <dbReference type="GeneID" id="27901727"/>
    <dbReference type="eggNOG" id="ENOG502STV9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1224555_0_0_1"/>
    <dbReference type="OMA" id="PPCTMGD"/>
    <dbReference type="OrthoDB" id="3910171at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="203"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF14070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="278" mass="30291" checksum="6BB6154BA243D26B" modified="2013-05-01" version="1">MLFDENFTFEPPRSPSSGSDTTTTTTSSFTTRDTSRAVSPCTSSSSAGSAASPVPRFSVTDLAVDFASSRLRHEAQICYDSCEAYANMDDDDASWEIPGSDDSNDSSSMTETLSRPRTLPPPPVLQRSYSPSRRMARQLNTRLLCSTSHAKDIAALVGQMVERKEHCNVVMMRSDSRMQRCDTNMNMSNNNEDEGYDSGTGGSTTTRLSSRRSSSIFAVQQQQQQRPRLVDYRRMSDLKLAAGGGCGGGGGGARVCKTIRQKKSIKCIRVRSGGETVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M3D8H3</accession>
    <name>M3D8H3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Cytochrome c oxidase subunit 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 12">Cytochrome c oxidase polypeptide VIIA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SEPMUDRAFT_124443</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the fungal cytochrome c oxidase subunit 7a family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762315.1">
        <property type="nucleotide sequence ID" value="XM_016901911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D8H3"/>
    <dbReference type="STRING" id="692275.M3D8H3"/>
    <dbReference type="GeneID" id="27899048"/>
    <dbReference type="eggNOG" id="ENOG502SBM8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_196969_0_0_1"/>
    <dbReference type="OMA" id="ASYWWWG"/>
    <dbReference type="OrthoDB" id="2317211at2759"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22888">
        <property type="entry name" value="CcO_VIIa_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014368">
        <property type="entry name" value="Cyt_c_oxidase_su7a_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28264:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28264">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000283">
        <property type="entry name" value="COX9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMF14194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="61" mass="7053" checksum="70C3142831FA39F7" modified="2013-05-01" version="1">MVKPITGMLRRGLVLDLSVAFGLGTSFGYLWWYGFHVPSVRRRDVFYAKLEDQRANAFSQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M3D8R5</accession>
    <name>M3D8R5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal RNA-processing protein 41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_155223</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Component of the RNA exosome complex. Specifically part of the catalytically inactive RNA exosome core complex (Exo-9) which may associate with the catalytic subunits RRP6 and DIS3 in cytoplasmic- and nuclear-specific RNA exosome complex forms. Exo-9 is formed by a hexameric base ring of RNase PH domain-containing subunits and a cap ring consisting of CSL4, RRP4 and RRP40.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762646.1">
        <property type="nucleotide sequence ID" value="XM_016907606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D8R5"/>
    <dbReference type="STRING" id="692275.M3D8R5"/>
    <dbReference type="GeneID" id="27904743"/>
    <dbReference type="eggNOG" id="KOG1068">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063514_0_1_1"/>
    <dbReference type="OMA" id="ENQMLSI"/>
    <dbReference type="OrthoDB" id="437922at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11370">
        <property type="entry name" value="RNase_PH_RRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Exosome complex component Rrp41"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ExoRNase_PH_dom1"/>
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        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF0">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
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    </dbReference>
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    </dbReference>
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    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="10" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="8">
        <location>
            <begin position="139"/>
            <end position="273"/>
        </location>
    </feature>
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        <location>
            <begin position="276"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00063066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00077929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF14525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="371" mass="39902" checksum="47DE0E345C89C0DB" modified="2013-05-01" version="1">MSTPIWVLQRPSMLWCVSTPQHERAQSAYESRSTDFYGGLHSENSATFEVAFRDGAGSVESTCKAAPLHKLALSGAATVFCASTLYLLRRHSGMNAPDPAAVTSDEMGGSSNKTQQEMPLDSSTYALAHLRVDGRRWNELRCISGQMSTQAAADGSSYFEMGNTKVICTVVGPRQQTRSGGGGGRDQTKEASIEVEIGIAGFSGMDRKKRSRSDKRTQEMQYTISSAFASTVFTSLYPQSTISIVLHVLSQDGALLAACLNAATLALIDAGVPMKDYVAACTVGSTASYASNEEEADPLLDLNGLEEQELPFMTVGTSGGEDMVNVLIMETRVQMARLQAMLSVGLDGCKQIRQLLDGIVREHGKKLLKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M3D8T8</accession>
    <name>M3D8T8_SPHMS</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_155073</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016907599.1"/>
    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502SXNH">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1042029_0_0_1"/>
    <dbReference type="OMA" id="TERTQCT"/>
    <dbReference type="OrthoDB" id="3818343at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF14309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="285" mass="32642" checksum="2059A1E8C4A8F4E9" modified="2013-05-01" version="1">MASTTPSPFLSLPQELRDIIYQHALRDSLRRYDDLGEYKANEIPMPAKQEHDNNIADGGLLFNYTAQCPRPVWYTLLLCCRTTNRDIRELAQTTALNQMIDIKPAVVDLNLSPTTSTATWQHLPSHPQQITSLQINIRLSHIYESSLTSASPDTDNAIIRAIFHLVRQYCCFGPHLSRGKPLSRPLQLETVLLEIEPDLRAIQPPQGLVFANNHPQQLATVSGVFWIWLSRFARSGLLWERVENLKWNCKYIAETEGEVVTSRVTNHGWSEDDRTMFRELGYSWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M3D8W1</accession>
    <name>M3D8W1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_148249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016904802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D8W1"/>
    <dbReference type="GeneID" id="27901939"/>
    <dbReference type="eggNOG" id="ENOG502R9BC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118221_0_0_1"/>
    <dbReference type="OrthoDB" id="3648924at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF14580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="200" mass="21522" checksum="0648C202C679A55E" modified="2013-05-01" version="1">MAGHDASVNIRVSLLTAQILEYWGVCHAKLARSKARKAAVPLAYVPQVSGALQIIEPRTLSRPQAPASRKSSLQSIQSNLHDKAAATCLVQNVSVLSQSHDVPQWRPDQTPDWALGGEDSPRCSFESHQSVTSQVDFSIEKPKDYINLSDLMDSATMLVGFGSRDVGSSSNSSSSRRGSSVSTPSRASSIREVESSAGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M3DBF7</accession>
    <name>M3DBF7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carbohydrate esterase family 5 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_147130</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763310.1">
        <property type="nucleotide sequence ID" value="XM_016904103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DBF7"/>
    <dbReference type="STRING" id="692275.M3DBF7"/>
    <dbReference type="GeneID" id="27901240"/>
    <dbReference type="eggNOG" id="ENOG502SQ4D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040058_4_2_1"/>
    <dbReference type="OMA" id="PRHVPGK"/>
    <dbReference type="OrthoDB" id="2586582at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630:SF9">
        <property type="entry name" value="CUTINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630">
        <property type="entry name" value="CUTINASE RV1984C-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032358" evidence="3">
        <location>
            <begin position="20"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF15189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="238" mass="24821" checksum="08D823CECAF376BF" modified="2013-05-01" version="1">MVGFTTLALSALLSSLATSSPISSPSSLLPTKRQITCVPSSGLYILVARGSNQPEGEGSVGPVANLIEAQLAGSYSHAIDYPATIISWESNYFSSVEDGIEDTKKSIQEYVAACGEDARIALIGYSQGGNVMTDTLAGGTGKPEPIAESYRKNIVGVAVFADPRFNAGKAYSRGTSTEDGIFGRDSSAAALDTWADVLVSYCDADDLFCASGGSLDVHYAAVEKYSQQAADFIIGLAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M3DCN2</accession>
    <name>M3DCN2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Porphobilinogen deaminase</fullName>
            <ecNumber evidence="5">2.5.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Hydroxymethylbilane synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Pre-uroporphyrinogen synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SEPMUDRAFT_147583</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57845"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="EC" id="2.5.1.61"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>dipyrromethane</name>
            <dbReference type="ChEBI" id="CHEBI:60342"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HMBS family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.61" evidence="5"/>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763911.1">
        <property type="nucleotide sequence ID" value="XM_016904392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DCN2"/>
    <dbReference type="STRING" id="692275.M3DCN2"/>
    <dbReference type="GeneID" id="27901529"/>
    <dbReference type="eggNOG" id="KOG2892">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019704_0_2_1"/>
    <dbReference type="OMA" id="LWQANHI"/>
    <dbReference type="OrthoDB" id="564646at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00319"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004418">
        <property type="term" value="F:hydroxymethylbilane synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd13645">
        <property type="entry name" value="PBP2_HuPBGD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000005">
        <property type="entry name" value="Porphobilinogen deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000086">
        <property type="entry name" value="Probable porphobilinogen deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.40">
        <property type="entry name" value="Porphobilinogen deaminase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000860">
        <property type="entry name" value="HemC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022419">
        <property type="entry name" value="Porphobilin_deaminase_cofac_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022417">
        <property type="entry name" value="Porphobilin_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022418">
        <property type="entry name" value="Porphobilinogen_deaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036803">
        <property type="entry name" value="Porphobilinogen_deaminase_C_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00212">
        <property type="entry name" value="hemC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557">
        <property type="entry name" value="PORPHOBILINOGEN DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557:SF0">
        <property type="entry name" value="PORPHOBILINOGEN DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01379">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03900">
        <property type="entry name" value="Porphobil_deamC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00151">
        <property type="entry name" value="PORPHBDMNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54782">
        <property type="entry name" value="Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00533">
        <property type="entry name" value="PORPHOBILINOGEN_DEAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="9" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Porphobilinogen deaminase N-terminal" evidence="13">
        <location>
            <begin position="36"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Porphobilinogen deaminase C-terminal" evidence="14">
        <location>
            <begin position="264"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMF15790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="400" mass="43692" checksum="0571B26CB97E1F76" modified="2013-05-01" version="1">MATEATNTTVTAPPADDNSHIVIRARQETANTQTFHVGTRRSILARKQADEVVKALREAWPEHHFEIHAMSTTGDNNQKTALHKFNEKALWTQELEVLLEDGSLDLIVHSLKDMPTQLPVGLSLGCVTKREDARDALVLKPTLVDKVKSLKDLPEGAVVGTSSLRRTAQLKRFYPQLQFQDVRGNIGTRLAKLDDPSSDYSAICIAVAGLERLGLSHRIGSYLSKDNGGMLHAVGQGALGIEIRSDDTRTAELLSRIGDDQSWRQALVERALMRTLEGGCSVPIGVETEWVSKSRMHDQHAGVGIKPAETYDKASGAATNIGGTKALEDELSDELVMRAIVVSLDGQEAAEIETRRRVLTHEQANEFGFDVAKMLVEKGADKILAQVQLNRGIIKDQGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M3DDJ7</accession>
    <name>M3DDJ7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_106078</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764010.1">
        <property type="nucleotide sequence ID" value="XM_016900610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DDJ7"/>
    <dbReference type="GeneID" id="27897747"/>
    <dbReference type="eggNOG" id="ENOG502SP43">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108094_0_0_1"/>
    <dbReference type="OMA" id="PHFGTLC"/>
    <dbReference type="OrthoDB" id="3890746at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF15889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="239" mass="26329" checksum="D7C5C10ED5ACE21A" modified="2013-05-01" version="1">MPTPPTHRLPHLLLPLLSITLNLAILGTSSRTLHIYQTSQTSNVYFLPIWNSHFDMRGLKTLVGTSVGIVVLNGIFAVVGGVCGNGNGSRRMLQHVPTNTILLASSVSSTLLSIIALALQATLNHQSPHRDTLQTWTCMWKNVQGEGVPQSFDTLCHETRFAFYTTIPSFLIQLSLLALACYALTAKSATSAHKRRSVIRLDEEEKAHELVERQQQSFDTKSDSARSTPDQVRVVAGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDK6</accession>
    <name>N1QDK6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_120383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757657.1">
        <property type="nucleotide sequence ID" value="XM_016901600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QDK6"/>
    <dbReference type="GeneID" id="27898737"/>
    <dbReference type="eggNOG" id="ENOG502RM57">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_174939_0_0_1"/>
    <dbReference type="OMA" id="NANFDEH"/>
    <dbReference type="OrthoDB" id="422736at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="103" mass="11519" checksum="669D94DA5A954546" modified="2013-06-26" version="1">MQNIRSKIKRKLSMRDKDVNVDDYDEASDVDEETTGHLHREIEKAEKEGHDAGRPGTFLNKLILHGNKKTEDQLAKEAAYANQGGQQQIGQQSVGTSEEGVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDP8</accession>
    <name>N1QDP8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein kinase C</fullName>
            <ecNumber evidence="2">2.7.11.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">SEPMUDRAFT_151592</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.13" evidence="2"/>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757767.1">
        <property type="nucleotide sequence ID" value="XM_016906913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QDP8"/>
    <dbReference type="STRING" id="692275.N1QDP8"/>
    <dbReference type="GeneID" id="27904050"/>
    <dbReference type="eggNOG" id="KOG0694">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_54_0_1"/>
    <dbReference type="OMA" id="QCTHLVP"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004697">
        <property type="term" value="F:diacylglycerol-dependent serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902660">
        <property type="term" value="P:negative regulation of glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000425">
        <property type="term" value="P:pexophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903139">
        <property type="term" value="P:positive regulation of cell integrity MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010606">
        <property type="term" value="P:positive regulation of cytoplasmic mRNA processing body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090334">
        <property type="term" value="P:regulation of cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000769">
        <property type="term" value="P:regulation of establishment or maintenance of cell polarity regulating cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070610">
        <property type="term" value="P:regulation of fungal-type cell wall (1-&gt;3)-alpha-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060237">
        <property type="term" value="P:regulation of fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060211">
        <property type="term" value="P:regulation of nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd20822">
        <property type="entry name" value="C1_ScPKC1-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20823">
        <property type="entry name" value="C1_ScPKC1-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11620">
        <property type="entry name" value="HR1_PKC-like_2_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05570">
        <property type="entry name" value="STKc_PKC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.160:FF:000004">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000101">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000103">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000014">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000034">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.160">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011072">
        <property type="entry name" value="HR1_rho-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036274">
        <property type="entry name" value="HR1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037312">
        <property type="entry name" value="PKC-like_HR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02185">
        <property type="entry name" value="HR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00742">
        <property type="entry name" value="Hr1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46585">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51860">
        <property type="entry name" value="REM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="REM-1" evidence="22">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="REM-1" evidence="22">
        <location>
            <begin position="154"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="18">
        <location>
            <begin position="238"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="20">
        <location>
            <begin position="469"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="20">
        <location>
            <begin position="537"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="876"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="21">
        <location>
            <begin position="1136"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="63"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="361"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="608"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="653"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="695"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="711"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="819"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="905"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EMF09646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1201" mass="132384" checksum="42A5F9A25BA2C803" modified="2013-06-26" version="1">MEDGAATQEIYRRIEREKKLIQAATQMRQATGNAQVVSKADSEIREARRNIQYFEQKLNDLRDRNVGNSMGNLSLAGNGGPPTPSHGRGGSSGSGYNNEQGHGGVADYGNPGPGGYSMGGAPGLMPPRAPYAPPGPGDRSPRARPNYSKLDLIKYDTPHLGPRIQLMLSQLEFKLSVEKQYKDGVEKMVKLYEMAGDRRSRGEAELRRMESNQKIQLLTRALRRYEDLHVDVENGADAADDDSLDTPSQRKPLTGHMSVRIHAIDNVDHAASGRFSRGPDTFVVMKVEDALKGRTKATKTDRWTDENHEFDVDKANEIEFTVYDKSSGDHPIPVGFLWIRLSDLVDEIRRKRIETEFNQAGWKTADQMDGSTPRPDLQFSPPPSSSHGVGAPGGGSLGASAAGGPAGAGLAPQTGPVYIDAWFTLEPVGKIHLTVSFIKQVKDRRPFDVGLNRKGAVRQKKEDVVVQYGHKFVVQTFYNIMRCALCGDFLKYTAGMQCADCKYTCHKNCYPKVVTKCISKSNSETDPDEEKINHRIPHRFDAFSNMGANWCCHCGYMLPIGRRQARRCTECKLTTHANCVHFVPDFCGMDMKTANEILAALKEKKKAVDTAKGHGRPMLDTLRAPGKQTGGRPTPPPQNASYMPTPGHQDQVAQKEQERLAGDRFSYGKDRMSDSYDQPPRTSSFGAPGADLGSASGQVPSSPESAHRPPAQRTQSSQSTAAAAAAAAATAAMSGKRSSGNERPGYGRGATDSYAQQQRGSGGSYADGYAESKRLPPQPGQQQSTYNPADYAAVAGYSSGPPYQQAVSPPPQPPAKTYAQQVPQVQAPVAAPARAQSPSVAPTPSVSVTEPVVEQRKPAPPANTAGTGRRIGLDHFNFLAVLGKGNFGKVMLAETKTSKQLYAIKVLKKEFIIENDEVESTRSEKRVFLIANKERHPFLLNLHACFQTETRIYFVMEYISGGDLMLHIQRGQFGTKRAQFYAAEVCLALKYFHENGVIYRDLKLDNILLTLDGHIKIADYGLCKEDMWYGSTTSTFCGTPEFMAPEILLDKKYGRAVDWWAFGVLIYQMLLQQSPFRGEDEDEIYDAILADEPLYPIHMPRDSVSILQKLLTREPELRLGSGPTDAQEIMSHAFFRNVNWEDVYYKRVTPPFMPTVKSRADTSNFDSEFTSVTPVLTPVQSVLSQAMQEEFRGFSYSADFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDX4</accession>
    <name>N1QDX4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lytic polysaccharide monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_143102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758537.1">
        <property type="nucleotide sequence ID" value="XM_016903026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QDX4"/>
    <dbReference type="STRING" id="692275.N1QDX4"/>
    <dbReference type="GeneID" id="27900163"/>
    <dbReference type="eggNOG" id="ENOG502S34E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032571_2_2_1"/>
    <dbReference type="OMA" id="VYPCRGY"/>
    <dbReference type="OrthoDB" id="2342176at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110683" description="Lytic polysaccharide monooxygenase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF10416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="34335" checksum="67D1EAA2541EA8AC" modified="2013-06-26" version="1">MRFVNAVAGLALSAAGASAHMQLFYPAPFNASNNPHRTTATADPYLEFPYDCCGENDRWVYPCRGYESLLGSPDGAPTATWEAGSTVNFTLWAPGELGGNHYGGSCQVGFSTDSARSFHVATSYEGNCPHRNNGNGPDGQSFEFQVPRDLKQGVRLFAWIWYNREQEFNMNCAAVEIVSPTPPVSSSSIMNYPSSTVANHEPIPSATSYETANGCDCLCAAPVNISTCVCTDCDEASETAGYARDTDNPTSMAFAERPLMFVADNGNDCETPRSTAELKYPDPGPEVVSGDGVYPVELPSGACGQEEMLAKQAYNDKIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>N1QE54</accession>
    <name>N1QE54_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">U5 small nuclear ribonucleo protein component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_89823</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758716.1">
        <property type="nucleotide sequence ID" value="XM_016910510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QE54"/>
    <dbReference type="STRING" id="692275.N1QE54"/>
    <dbReference type="GeneID" id="27907647"/>
    <dbReference type="eggNOG" id="KOG0468">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002794_11_2_1"/>
    <dbReference type="OMA" id="YIFRPIR"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04098">
        <property type="entry name" value="eEF2_C_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04090">
        <property type="entry name" value="EF2_II_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01683">
        <property type="entry name" value="EF2_IV_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16264">
        <property type="entry name" value="snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04167">
        <property type="entry name" value="Snu114p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000004">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000029">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000009">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1430.10:FF:000001">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001452">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1430.10">
        <property type="entry name" value="Yeast translation eEF2 (G' domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031950">
        <property type="entry name" value="EFTUD2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044121">
        <property type="entry name" value="Snu114_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035655">
        <property type="entry name" value="U5-116kDa_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF6">
        <property type="entry name" value="116 KDA U5 SMALL NUCLEAR RIBONUCLEOPROTEIN COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16004">
        <property type="entry name" value="EFTUD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="8">
        <location>
            <begin position="130"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF10595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="986" mass="109909" checksum="C17C462F6559C081" modified="2013-06-26" version="1">MDDLYDEFGNYIGEPEESEDDVDAGADNGAQYLDDDEDEPPATTGQELMEIDDEGPSNAVVLHEDKQYYPSASQIYGPDVETLVQEEDTQTLQQPIVAPVEKQKFTIEETDLPHVYFDRGFMTDLMSFPEQIRNIALCGHLHHGKTSIMDMLVTQTHDLSKFMEGKTGKARDETIKYTDTHILERERGLSVKASPMSLLLQGTKGKSHLLNIIDTPGHVNFADEVAASLRLVDGVVLVVDVVEGVQVQTELAIKHAVLAGLPLVLMINKVDRLMLELKLPPNDAYFKLKHVVEEVNTFIENTIPGQGEKFRVSPEKGNVAFACSSMEWCFTLPSFATMYAENYPSAEFDVQEFSKRLWGDIYYNPGSRKFTRKGVEDRSKRSFVHFVLEPIYKLYSHTLSESPADLKKTLGSLGISLKPSQLKANAKDLLRLVCEQFFGPATGFVDMVVQHIPSPVQGARQKLEKYYTGPMDTKTAQSMLECDADGPLVVHVTKLFNTQDAQGFHSFGRVMSGTARPGQQVRVLGENYSIDDEEDMVNATIEQVWIAESRYNVPVSGMPAGNFVLLGGIDNSIMKTATVIAPKLPDEEEAYIFKPVAHFFESVFKVAVEPINPSELPKMLNGLRHINKSYPLITTKVEESGEHVVLGTGELYMDCVLHDLRKLYAQMEIKISDPVTRFCETCVDQSAMKCYALTPNKKNKLTFVAEPLDDGIAEDIESGKVSIKDPVRKVGKFFEENYGYDILASRNIWAFGPDDMGPNILQNDTLPSDVDQKLLRSVKDTIRQGFSWGTREGPLCEEPIRNVKFKITDVELASEAIFRGGGQIIPTARRACYSSFLMAGPRLMEPMYSCTMLGPANSVSSLYTVLARRRGHVLSDAPIPGTPLYSVQGLIPVIDSFGFETDLRIHTQGQATVSLVFDRWQVVPGDPLDKSVKLRPLEPASAQATARDFVLKTRRRKGLSEDVTVSKYVEPEIMRQLRETGMLDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1QE56</accession>
    <name>N1QE56_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PWI domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_48538</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758721.1">
        <property type="nucleotide sequence ID" value="XM_016909072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QE56"/>
    <dbReference type="STRING" id="692275.N1QE56"/>
    <dbReference type="GeneID" id="27906209"/>
    <dbReference type="eggNOG" id="KOG2146">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032410_3_0_1"/>
    <dbReference type="OMA" id="WISNRIT"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.10">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036483">
        <property type="entry name" value="PWI_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052225">
        <property type="entry name" value="Ser/Arg_repetitive_matrix"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23148">
        <property type="entry name" value="SERINE/ARGININE REGULATED NUCLEAR MATRIX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23148:SF0">
        <property type="entry name" value="SERINE_ARGININE REPETITIVE MATRIX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00311">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101233">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51025">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWI" evidence="3">
        <location>
            <begin position="3"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="115"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="115"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF10600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="146" mass="16942" checksum="4E65FA7C7C8CB783" modified="2013-06-26" version="1">MRNTKWPEEFSKKVNISKVNLPVIKKWVSDEITRILNSDDDVVTEMMFTFLESGKFPNIKQIQTDISGFLDKDAAPFCRQLWKLLLSAQSDPKGIPQELLEAKKFELIQERVRADRADKRAENREKLTCDAASRRQGTRRSQTARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1QEG8</accession>
    <name>N1QEG8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_151412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757478.1">
        <property type="nucleotide sequence ID" value="XM_016906804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QEG8"/>
    <dbReference type="GeneID" id="27903941"/>
    <dbReference type="HOGENOM" id="CLU_2238288_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="105" mass="11543" checksum="A9E56B7643205974" modified="2013-06-26" version="1">MSQCTHTHLCTSRTVTRIMKCFGLVQWQILAELSDRGKSRNTSQATRMMSELVTSSAKTHKATAVILYTSGRKTIGDLGQSIPSSKNSQLTERPHNYASASPEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>N1QER3</accession>
    <name>N1QER3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Very-long-chain 3-oxoacyl-CoA reductase</fullName>
            <ecNumber evidence="12">1.1.1.330</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">3-ketoacyl-CoA reductase</fullName>
            <shortName evidence="12">3-ketoreductase</shortName>
            <shortName evidence="12">KAR</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Microsomal beta-keto-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SEPMUDRAFT_127516</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3-ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP(+) = a very-long-chain 3-oxoacyl-CoA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="EC" id="1.1.1.330"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Endoplasmic reticulum membrane</location>
            <topology evidence="12">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.330" evidence="12"/>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759066.1">
        <property type="nucleotide sequence ID" value="XM_016902152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QER3"/>
    <dbReference type="STRING" id="692275.N1QER3"/>
    <dbReference type="GeneID" id="27899289"/>
    <dbReference type="eggNOG" id="KOG1014">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_38_0_1"/>
    <dbReference type="OMA" id="LVAPGMM"/>
    <dbReference type="OrthoDB" id="5545019at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045703">
        <property type="term" value="F:ketoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141040">
        <property type="term" value="F:very-long-chain 3-oxoacyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05356">
        <property type="entry name" value="17beta-HSD1_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000317">
        <property type="entry name" value="Very-long-chain 3-oxoacyl-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03107">
        <property type="entry name" value="3_ketoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027533">
        <property type="entry name" value="3_ketoreductase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43086:SF2">
        <property type="entry name" value="HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43086">
        <property type="entry name" value="VERY-LONG-CHAIN 3-OXOOACYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000126">
        <property type="entry name" value="11-beta-HSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 12" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0521">NADP</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005690581" description="Very-long-chain 3-oxoacyl-CoA reductase" evidence="13">
        <location>
            <begin position="19"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMF10945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="311" mass="33975" checksum="8D2BD1408500D1C0" modified="2013-06-26" version="1">MGLLWLSWHIFSFWRLMASLFILPGTSLSKFGKKGSWAVVTGASDGIGKEYALQLAAKGFNILLVSRTQSKLETLATEIQQKHNVQTKLYAMDFAANNDADFANLKTLVSELDVSILINNVGQSHSIPVPFAETPEKELKDIITINCFGTLRVTQLVVPGMIQRKRGLILTMASFGGIMPTPLLATYSGSKAFLQQWSTALSGELASSNIKVQLVQSYLVTSAMSKIRRSSAMIPNPKQFVRAALGKIGRSGGAQGIAATSTPYWSHGVMHWGIKTFAGTMNGLVLGFNQKMHVDIRKRALRKAERDAKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>N1QEU4</accession>
    <name>N1QEU4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">alpha-glucosidase</fullName>
            <ecNumber evidence="5">3.2.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Glucosidase II subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">SEPMUDRAFT_149557</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; N-glycan metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="5"/>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759743.1">
        <property type="nucleotide sequence ID" value="XM_016905629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QEU4"/>
    <dbReference type="STRING" id="692275.N1QEU4"/>
    <dbReference type="GeneID" id="27902766"/>
    <dbReference type="eggNOG" id="KOG1066">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000631_7_0_1"/>
    <dbReference type="OMA" id="TVHQPLW"/>
    <dbReference type="OrthoDB" id="3237269at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017177">
        <property type="term" value="C:glucosidase II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106407">
        <property type="term" value="F:Glc2Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033919">
        <property type="term" value="F:glucan 1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070880">
        <property type="term" value="P:fungal-type cell wall beta-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06603">
        <property type="entry name" value="GH31_GANC_GANAB_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033403">
        <property type="entry name" value="DUF5110"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030458">
        <property type="entry name" value="Glyco_hydro_31_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF54">
        <property type="entry name" value="BCDNA.GH04962"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17137">
        <property type="entry name" value="DUF5110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00129">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 12 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109526" description="alpha-glucosidase" evidence="14">
        <location>
            <begin position="29"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="16">
        <location>
            <begin position="95"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="15">
        <location>
            <begin position="401"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="18">
        <location>
            <begin position="740"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5110" evidence="17">
        <location>
            <begin position="847"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="210"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF17137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EMF11622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1005" mass="113447" checksum="024E273B3CD88699" modified="2013-06-26" version="1">MKRFHGSWHSSVLLFLLATFAFITPAVSVKHENFKTCDQSGFCKRNRLYADTALSTANWEAPYSLDRSSINFNNGILTGTVYKKLANSAESVRLPVKISFYESGVARVTIDEERRQKGQIELRHDSKIRKERYNEAEQWSIVGGTTLSAGAALSKDAEKGTTKVVYGPASTFEAVIHHSPFSIEWLRDGETQISFNDRGLMNLEHWRKKVEKKEPEQKEGEGEAEGTAEQKEDKSGEEESTWWEESFGGNTDTKPRGPEAVALDISFPGYDHVYGLAEHASPLNLKETRGGDGKYSEPYRLYNSDVFEYEMDSPMTLYGSIPLLQAHKKHSTVGVFWLNAAETWVDVTKRSSLAKRVGLGSNIVTDSHFISESGLLDVFVFLGPTPQDVIGKYAELTGTTQLPQHFSIAYHQCRWNYVTDEDVKDVDKKFDKNNIPYDVIWLDIEYTDGKKYFTWDALTFKDPLGMQKQLDEHERKLVAIIDPHIKNEGNYPVVDELKSKDLAVHNKDDKTYEGWCWPGSSHWVDTFSLAARKWWASLYQYSKFPGSAKNLFLWNDMNEPSVFNGPETTMPKDNIHHGGWEHRDVHNLYGMTLINATYEGLLARDKEEAKHNVRPFVLTRSFFSGSQRLGAMWTGDNQAEWSHLAASIPMVLSMGISGFPFAGADVGGFFGNPEKDLLTRWYQAGIWYPFFRGHAHIDTRRREPYLVGEPYKELITQALRLRYSLLPAWYTAFHEAHVSGAPIVRPNYYVFPGDEKGFAIDDQLYLGSTGLLAKPVTKADQPGTPIYLADKEKYYDYFDYWTYQGPGEVVVSSPLETIPLLMQGGKIFPRRDRPRRSSGLMKFDPFTLVVVIGESGDAEGTLYLDDGESFDYQVGAYIHRKFAFNGTTDCLSSEDLNTSAGGSTSNSKTIQAYLQSMEKVRVEKIIFVGAPETWKGKASVEVVVDGEKNQKKKKTTMVSELEFHEKEDGKAAWAVVRDPGVKIGSGWKITIGGQEGHAEGRKTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>N1QEW7</accession>
    <name>N1QEW7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 14">DNA replication licensing factor MCM6</fullName>
            <ecNumber evidence="3 14">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SEPMUDRAFT_51486</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3 14"/>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757693.1">
        <property type="nucleotide sequence ID" value="XM_016909193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QEW7"/>
    <dbReference type="STRING" id="692275.N1QEW7"/>
    <dbReference type="GeneID" id="27906330"/>
    <dbReference type="eggNOG" id="KOG0480">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000995_3_0_1"/>
    <dbReference type="OMA" id="RHQQTDK"/>
    <dbReference type="OrthoDB" id="1744952at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071162">
        <property type="term" value="C:CMG complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097373">
        <property type="term" value="C:MCM core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033679">
        <property type="term" value="F:3'-5' DNA/RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990518">
        <property type="term" value="F:single-stranded 3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902969">
        <property type="term" value="P:mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006267">
        <property type="term" value="P:pre-replicative complex assembly involved in nuclear cell cycle DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17757">
        <property type="entry name" value="MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.870:FF:000002">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000115">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008049">
        <property type="entry name" value="MCM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041024">
        <property type="entry name" value="Mcm6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF43">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18263">
        <property type="entry name" value="WHD_MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01662">
        <property type="entry name" value="MCMPROTEIN6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 14" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="16">
        <location>
            <begin position="483"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="184"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="800"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="185"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="800"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU368064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMF09572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="964" mass="106356" checksum="D85A0B15AC127F51" modified="2013-06-26" version="1">MSSDNAPTPREPRSDASAGRRRQARSSSRPRGTGTPRGPPSVSTPGMGSDIDGFADDEVVGRRGMRRAATGAGDIPPVVDTTAETLGIQFERFLENFTEDPTPSAQPISSAVTTNKYYIAQVHGLAQFGLSTLYVDFTHLMDHERGILANAIQGDFYRFQPYMLRALNSLIAKYEPQYYRMHRQPGSTTARTDTSQATQSISEDDEGNLNDKTPNQQTDKIFTLAFYNLPLVSRVRQLRTEQIGKLVSISGTVTRTSEVRPELHLATFICEVCNSLVPDVEQIFKYSEPTQCPNATCGNRQGWRLDIRQSTFIDWQKVKIQENSSEIPTGSMPRTMEVILRGEMVDRAKAGEKCIFTGTLIVVPDVSQFRVPGMRVQAVRDTQAPRGSDTGGAGVSGLKALGVRDLTYRMAFLANMLTPDTSTQGRHSSQNLKGQAGNLMSSLAQNVDSSDGVSGEKAQQEYLDTLTPAEIDELRDMVQSDNIYMRLVDSLAPMVYGHTIVKKGLLLQMMGGVSKTTPEGMALRGDINICIVGDPSTSKSQFLKYVCSFLPRAVYTSGKASSAAGLTAAVVKDEETGEFTIEAGALMLADNGICAIDEFDKMDIADQVAIHEAMEQQTISIAKAGIQATLNARTSILAAANPVGGRYNRKTTLRANINMSAPIMSRFDLFHVVLDECNEDVDEHLAKHIVGLHQKKDDAIEPEFSTEQLQRYIRFARLFQPVFTEQARQYLVQKYKELRADDAQGGIGRNSYRITVRQLESLIRLSEAIAKANCVDEVTPNFVDEAFKLLQQSIISVEKDDVEFEDDEEATAAEDTEAGAAPAEDEDAPMDGNEQGDAATPARTRASQTPAPSRPKTQIKFDDFIKIQTLLLKRVNQDQNEEQDGVEEMELLQWYTEQVEEEIHDTEGLSAQKSLAKKVLKRMVKNNVLMKVQGEGLAEEDGTGLERTERTIYVVHPNCSTDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1QF29</accession>
    <name>N1QF29_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA-splicing endonuclease subunit Sen54 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_92586</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEN54 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757798.1">
        <property type="nucleotide sequence ID" value="XM_016910588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QF29"/>
    <dbReference type="STRING" id="692275.N1QF29"/>
    <dbReference type="GeneID" id="27907725"/>
    <dbReference type="eggNOG" id="KOG4772">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028449_2_0_1"/>
    <dbReference type="OMA" id="MYMRLRH"/>
    <dbReference type="OrthoDB" id="408683at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024337">
        <property type="entry name" value="tRNA_splic_suSen54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024336">
        <property type="entry name" value="tRNA_splic_suSen54_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21027">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21027:SF1">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12928">
        <property type="entry name" value="tRNA_int_end_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA-splicing endonuclease subunit Sen54 N-terminal" evidence="4">
        <location>
            <begin position="70"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="428"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="156"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="435"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF09677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="453" mass="50528" checksum="A84165130EF005C9" modified="2013-06-26" version="1">MADADEDIIPRDGQPGGEEVDLSDEPQDFRFLTSISKSDAVIPKRGEKDFEPHATALQSNTLAASRQAMHNVLSFERVHQPKGHTIGIYHPETNMCYAMNPKGPLFIRMGRVLPANESPFGDDELRGIRTWLYPEEALYLLERGTMDVRWPRTVQEDGDDGDDDDDDEEGESKLGLPMSLQAGYAMFLGDEESHPHEAATLTFERFSVYSGLKRAGYTVLRAPSWDSTGPALTPDCFPPLQPQNRTWQTGLTSIISSLKCFFIANPQKLERQQHARQVTGPIIPNDLYRNYQDIYHRLALVNFHDPTLAKPPSSTTAEAEEKTPRTEPPFRITYHVWKPGSAHFKKSAPVDPDFRIAVINARESNMPTLDQLGALLETTPYDPPKAEAHMHVKLKHGYKNVILAIVDQGVPSYLRIADAAFGREKVYERGTGGRGGKRGGRGGARGRGRGRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1QF65</accession>
    <name>N1QF65_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_149732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759999.1">
        <property type="nucleotide sequence ID" value="XM_016905736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QF65"/>
    <dbReference type="GeneID" id="27902873"/>
    <dbReference type="eggNOG" id="ENOG502S09K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071379_2_0_1"/>
    <dbReference type="OMA" id="VGAFHYG"/>
    <dbReference type="OrthoDB" id="5580261at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018811">
        <property type="entry name" value="MRX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28002">
        <property type="entry name" value="MIOREX COMPLEX COMPONENT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28002:SF1">
        <property type="entry name" value="MIOREX COMPLEX COMPONENT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10306">
        <property type="entry name" value="FLILHELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF11878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="215" mass="24040" checksum="2AB2A9D82097DA12" modified="2013-06-26" version="1">MNRLFRSAWNGRQAIRNNGTKHWASRLESTKSSPPVTKETARVARIESRLPKFLRRYVEPLRNAPISHISAFLILHEITAIVPLFGLAAAFHYANWLPPFISEGKWVSDGVEKFGRYMRKKGWINDDARGGRWFGRGETGTRIVVELATAYAVTKALLPLRLILSVWGTPWFATWTVLPITNRISRFFRRKKAAAAVSSPAAGSGATAAGVLPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1QF78</accession>
    <name>N1QF78_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carbohydrate esterase family 3 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_133804</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759943.1">
        <property type="nucleotide sequence ID" value="XM_016902588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QF78"/>
    <dbReference type="STRING" id="692275.N1QF78"/>
    <dbReference type="GeneID" id="27899725"/>
    <dbReference type="eggNOG" id="ENOG502SMB5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014183_0_0_1"/>
    <dbReference type="OMA" id="QGHEGDW"/>
    <dbReference type="OrthoDB" id="2119228at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01833">
        <property type="entry name" value="XynB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051532">
        <property type="entry name" value="Ester_Hydrolysis_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383:SF5">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383">
        <property type="entry name" value="THIOESTERASE 1/PROTEASE 1/LYSOPHOSPHOLIPASE L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110764" evidence="2">
        <location>
            <begin position="32"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="412"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="508"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF11822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="543" mass="59527" checksum="CFC9491AF0277A18" modified="2013-06-26" version="1">MRLAHHGSSNRPVLAYLLVLVLNLYPTSTLASEQSEDILNPLRVLVVGDSITHCNEGDFTWRYRIWQWFQSQPTTTTTTSETQQEQQQQQNLTIDFVGPYLGTAEPDLPSPPPRPRLYSLPKEDPPLRINGKYATDDFTNSNHFAISGRAVAQVKDTIQPVVAEFSPDLILVLLGFNDLAFGFGNASQTLENTKALIENSRSARPNVAFVVGNVVQRTWTGREDLVKLTDEYNGLLREAVAGWSLEGSPVVFAPVREEYDCGPQYTDNCPAAHDGLHPSELGEYQIARAFSRALVSGLQIGSTPLEVPATIPPRPLPKPENFEIYSSTIGVTAIWDKVFGAYTYDAEYRINGSDTNPPLHFSPTNVRANRWDTHWAVPKDTYDLRVRPIAGNRKGEWTDWQTAVTTPDTASAPEDVIVKATATGIDLNWTIPFGSSATLFNFYYWDVDVNCTNMLLGPTAAFEGTSGHIDGLVVGHQYNLAVESWNDAGAGLPRNVASAIVGSPETVAVPRDSVCPPKESIGAPPSTDPINPDDPQPPPKSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFA5</accession>
    <name>N1QFA5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_126267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759983.1">
        <property type="nucleotide sequence ID" value="XM_016902050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QFA5"/>
    <dbReference type="GeneID" id="27899187"/>
    <dbReference type="HOGENOM" id="CLU_2211627_0_0_1"/>
    <dbReference type="OrthoDB" id="10316680at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110769" evidence="1">
        <location>
            <begin position="18"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF11862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="107" mass="11925" checksum="07D4B5B6977AA1ED" modified="2013-06-26" version="1">MLKLHFGVMLFATMAAADRTFQRPPIYFGGCDYSPLGRDQAYYNCDWYGTKPGQGGQPECEAVIRDQGGCAWPCKRAGRSGESADWNYLAVAENDGQNICRCRCKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFS5</accession>
    <name>N1QFS5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_149911</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760284.1">
        <property type="nucleotide sequence ID" value="XM_016905849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QFS5"/>
    <dbReference type="GeneID" id="27902986"/>
    <dbReference type="HOGENOM" id="CLU_1579489_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF12163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="169" mass="19137" checksum="844B8A9444F425FD" modified="2013-06-26" version="1">MERMGATILYVHDHEYTFACFKDRMVSVEGGRQNSRVAGTHWKMFEAMNALMAELEREGDVTEMLHQPEEKYQEAKSTFLERLRKACQDAFDERAAMGHPRATADSLNLGLSEDDLTILGYRSDHKNPGYSGIRLRWMQEGEDSEANAGGLAAEHARSTRLGTEELPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFV5</accession>
    <name>N1QFV5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_142360</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760319.1">
        <property type="nucleotide sequence ID" value="XM_016902997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QFV5"/>
    <dbReference type="STRING" id="692275.N1QFV5"/>
    <dbReference type="GeneID" id="27900134"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_25_2_1"/>
    <dbReference type="OMA" id="WQEWLFE"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="519"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF12198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="599" mass="67588" checksum="E33BC9B9E0D969FF" modified="2013-06-26" version="1">MSSYVVIALALFGLYASTFVYTFILNYVHARKSNLPYVCVPWDQNHLFWMLASVPSRPFLKKHLPTWIWERLSLTVYAFEFTEKLRPFTQYAAPQGNDKTYVLVSMGYFEISTRDPEIAWEILSSQRSKTGFIQHDLIKVFMSRFGPNVLTSDGEAWARQRKVVASSITERISKRVFEESLRQVEGLLEEVFLLDGCGGGGGGGGDESRCETERLFDGMKKITINVLSSAGMGESVEWKDEKNSSPEPGFRMTYIQAVNAVIDAVAGPLVLPKWFLSYYPTFLPGGKFLRSVGYAIEEFPIHTKALLERENKKSALEGKTRSNIMSQLLRASESETKDGVRTLSDEEMMGNLFIFTAAGFDTNANALSYALVLLARYPQWQEWISEEIDAIIPAEMSIAEMDYASIIPKATRTLATMLETLRLFPPAIHMAKQTKVEQTITTSRGTFWIPANATVYINNIGLGRDPDVWRNLNLKDGETSNEVDDETVFRPSRWINADGGLFQPPRGTFSPWSSGPRICPGMKMAQVEFTSIFLMLLRRHRIEAVAMCKSANGEVENRREVEKRLDQSIEDSIAILTLQLPNVYDQKKGEGIKLAVVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFZ1</accession>
    <name>N1QFZ1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sdh_cyt-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_126495</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760313.1">
        <property type="nucleotide sequence ID" value="XM_016902076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QFZ1"/>
    <dbReference type="STRING" id="692275.N1QFZ1"/>
    <dbReference type="GeneID" id="27899213"/>
    <dbReference type="eggNOG" id="KOG0449">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094691_0_2_1"/>
    <dbReference type="OMA" id="PHDATHY"/>
    <dbReference type="OrthoDB" id="3647259at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03499">
        <property type="entry name" value="SQR_TypeC_SdhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014314">
        <property type="entry name" value="Succ_DH_cytb556"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02970">
        <property type="entry name" value="succ_dehyd_cytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978:SF5">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="Fumarate reductase respiratory complex transmembrane subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF12192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="196" mass="21357" checksum="1341A549F32CE9B2" modified="2013-06-26" version="1">MISTHGLCGLAPRVAAKPSSTILFAAFSRPTIVGIGLRHQNTKTTTTTTTTTTPEITLQKNPNEILIQQRLRRPLAPHLSIYKWQITSIPSTLTRITGVAMSGCFYLFGTLYLTAPYLGLDMSSATLAAAFGAWPVAIQMLTKFTLAWPLVFHSFNGLRYLSWDMTIGVNNRTVARTGWTAVVASLLATLGLVVLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1QG16</accession>
    <name>N1QG16_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_150720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758823.1">
        <property type="nucleotide sequence ID" value="XM_016906354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QG16"/>
    <dbReference type="GeneID" id="27903491"/>
    <dbReference type="HOGENOM" id="CLU_2414695_0_0_1"/>
    <dbReference type="OrthoDB" id="3647228at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF10702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="92" mass="10289" checksum="9990D4A3E513253E" modified="2013-06-26" version="1">MAPKIQPPSDPTALLWAHQMKREHGFLLDRMQKLEAAISRIEGLATAAQDVQALTEVAIDKSSAAAQQAVEKVRREVSTQFEDLECWNHTPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1QG84</accession>
    <name>N1QG84_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Golgi apparatus membrane protein TVP23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_150807</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Golgi membrane protein involved in vesicular trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Golgi apparatus membrane</location>
            <topology evidence="2 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TVP23 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758953.1">
        <property type="nucleotide sequence ID" value="XM_016906409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QG84"/>
    <dbReference type="STRING" id="692275.N1QG84"/>
    <dbReference type="GeneID" id="27903546"/>
    <dbReference type="eggNOG" id="KOG3195">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074845_1_1_1"/>
    <dbReference type="OMA" id="FEWMIVA"/>
    <dbReference type="OrthoDB" id="2151161at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008564">
        <property type="entry name" value="TVP23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13019">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13019:SF7">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05832">
        <property type="entry name" value="DUF846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF10832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="196" mass="21945" checksum="2139582BB26603A8" modified="2013-06-26" version="1">MADINPTPGQLNWRLSAHPITLLTFLSFRIASLLVYLLGMLFTSNFVMIFIITIILLAMDFYYLKNIAGRRLVGLRWWNEVNGQSGDSHWVFESAPQANEPGGKIVNATDKRFFWLALYAQPALWVALAVVALVKFMFVWLTLVAIAMVLTITNTLAFSRCDKFSQASGLVERGLFTGSLARNVGGAMFSRLFNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGG8</accession>
    <name>N1QGG8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mannose-6-phosphate isomerase</fullName>
            <ecNumber evidence="5">5.3.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Phosphohexomutase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Phosphomannose isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SEPMUDRAFT_152517</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-mannose 6-phosphate = D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12356"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="5.3.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the mannose-6-phosphate isomerase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.8" evidence="5"/>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764376.1">
        <property type="nucleotide sequence ID" value="XM_016907471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGG8"/>
    <dbReference type="STRING" id="692275.N1QGG8"/>
    <dbReference type="GeneID" id="27904608"/>
    <dbReference type="eggNOG" id="KOG2757">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026967_0_1_1"/>
    <dbReference type="OMA" id="QHYSEMW"/>
    <dbReference type="OrthoDB" id="6605218at2759"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00423"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07011">
        <property type="entry name" value="cupin_PMI_type_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.441.10">
        <property type="entry name" value="Phosphomannose Isomerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001250">
        <property type="entry name" value="Man6P_Isoase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016305">
        <property type="entry name" value="Mannose-6-P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046456">
        <property type="entry name" value="PMI_typeI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046457">
        <property type="entry name" value="PMI_typeI_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00218">
        <property type="entry name" value="manA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309:SF4">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01238">
        <property type="entry name" value="PMI_typeI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20511">
        <property type="entry name" value="PMI_typeI_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001480">
        <property type="entry name" value="Mannose-6-phosphate_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00714">
        <property type="entry name" value="MAN6PISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phosphomannose isomerase type I catalytic" evidence="15">
        <location>
            <begin position="8"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphomannose isomerase type I C-terminal" evidence="14">
        <location>
            <begin position="339"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001480-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF20511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMF16255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="425" mass="46764" checksum="64DB1C15E1159264" modified="2013-06-26" version="1">MTTKLESVYKLKCSCNQYPWGKQGRESIAARLCEKQQGWDGKGPQTPFKIDNDKSYAEMWMGTYPALPSYVEETGEDLQDVLDRYPKELIGQETLDKFGHSKLPYLPKVLSIAKALPLQLHPNKEVAARLHKENPSDFTDPNHKPEIALALGKFEAFCGFKPLADIADLLKLKPLQQFIPENTQLSSFTNQQLKSVVGNMLKSSESTVKSVYQGLTSLPSSDFGTKFSQIPTLAPRLAEQYGSSDPGNLVALITMNYLVLQAGESIYIPADGIHAYLSGDIIECMSRSNNVLNTGFCARADRDNIDLFLECLTFTPHSAQEAILKPEAYAKSKNGKSTVYAPPLREFDMLQTELKNAGEKEVLAAVGGPSIMLVTKGDGKMKVRGKEFHLNEGAVYFIGQGVDVEIESTTGELLLHTALVEGSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGV8</accession>
    <name>N1QGV8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycerophosphocholine acyltransferase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SEPMUDRAFT_145669</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GPC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764536.1">
        <property type="nucleotide sequence ID" value="XM_016903190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGV8"/>
    <dbReference type="GeneID" id="27900327"/>
    <dbReference type="eggNOG" id="KOG2895">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018994_0_1_1"/>
    <dbReference type="OMA" id="HTIKYST"/>
    <dbReference type="OrthoDB" id="406287at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021261">
        <property type="entry name" value="GPCAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31201:SF1">
        <property type="entry name" value="GLYCEROPHOSPHOCHOLINE ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31201">
        <property type="entry name" value="OS01G0585100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10998">
        <property type="entry name" value="DUF2838"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="451"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="72"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="519"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="522"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="575"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMF16415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="605" mass="69262" checksum="B7F10ECC0E963E84" modified="2013-06-26" version="1">MPISYNSELRRPYYAGHKSSYLDIIPEDELEAYARLEDIDAATKRTTTHTTHMASADMTQETDEMAAAKMADLRPPTEEAHGRSSSDSMRPQMEDYLTAGGGSASGASTPGTPGLSRTSSSDNVYASFDFDKEFPSVDRLSMFDILENLALPQRLERMQNAIHDNAEKLRRQRQKLAQRALSSKNVVVDEWRKRIPKSDDQLDRYRRRMKASVERLNKRWHDNKTVSMLEKVSFVTAVLNIFISGYLIGAMPEYFHYWYTAQLFYFMPIRWYKYHKIGFHYFLADLCYFVNMLLVLSIWFFPQSKRLFISTFCLAFGNNAVAIAMWRNSLVFHSLDKVTSLFIHIMPCVCLHVLVHCLPKEMQLEKFPAVHTIKYSTPDAPEHYSLKDMIIWATLPYAIWQLSYHFLITVRKRAKIAAGRPTSFTWLRRSYRGNVLGKFVLSFPESFQETIFMFIQYSYALLTMLPCPFWFWYRWASAGFMMLVFSWASWNGANYYIEVFGKRMEKELDQLRKEVARMSKSPDLTGQDGLTFSPLASPTGPTGASQAEDGAGEGVSSALDLGPPADAQGYNSSKTELDDGSGLHKRNDSVDAIPMLEGSEQKKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1QH34</accession>
    <name>N1QH34_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Delta(24)-sterol reductase</fullName>
            <ecNumber evidence="2">1.3.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_151393</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.3.1.72" evidence="2"/>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757445.1">
        <property type="nucleotide sequence ID" value="XM_016906788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QH34"/>
    <dbReference type="STRING" id="692275.N1QH34"/>
    <dbReference type="GeneID" id="27903925"/>
    <dbReference type="eggNOG" id="KOG1262">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025883_0_0_1"/>
    <dbReference type="OMA" id="WVGRSAF"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000246">
        <property type="term" value="F:Delta24(24-1) sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050614">
        <property type="term" value="F:Delta24-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000031">
        <property type="entry name" value="FAD binding domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040165">
        <property type="entry name" value="Diminuto-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10801">
        <property type="entry name" value="24-DEHYDROCHOLESTEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10801:SF10">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14300)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="26"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF09324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="541" mass="62029" checksum="C224F1C5D118EE3E" modified="2013-06-26" version="1">MPMTKHSKSIRPAPSLRVQRRHLLTRGGTAPTTIEAHQRQVDEISERVRGFYERKEKFRIFHGSTNSTRKSAMGRDPRTVVDTSRLNHVVSVDVEKMTALVEPNVPMDRLVEETLKYGLVPPVVMEFPGITVGGGYSGTAGESSSFKHGFFDRTLNNVEMVLATGEIITASETENSDLFRGAAGAVGTFGVTTMVELQLIKASRYVEATYHPVNSMEEATATLLDFTSKPDEFDYIDGIMYSQNSGAIVTGRMTDNPSAGIPEQRFSDPKDPWFYLHVKERIRNCEAPTSDVIPLPDYLFRYDRGGFWVGEGAFGYFKFPFANWSRRWLDDFLHTRMLYNALHSSGRSEQMIIQDLALPYDRATEFVKRMDEKLGIWPLWLCPLKQSPSPTMHPHYSEYEADGKTLKPMLNIGLWGKAPPTHEAFVKANREIEATLQELRGMKWLYAQTYFNENDFWKDFDRSWYEKLRQKYSATTLPTAWEKVHVSVEAEKNAKQKKSWTQRLLETWPMAGFVGIKRSIQSKDYVQARNPAWKDWVPRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1QHF1</accession>
    <name>N1QHF1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_69822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758699.1">
        <property type="nucleotide sequence ID" value="XM_016909879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QHF1"/>
    <dbReference type="GeneID" id="27907016"/>
    <dbReference type="HOGENOM" id="CLU_2352401_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF10578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="97" mass="11102" checksum="CBE6EEF174444734" modified="2013-06-26" version="1" fragment="single">MYGRRRLQWKLLIDSMCTEYYAVWSAYCCYCLSLTCPLLAESQVDGTDITVEQSKKIWETPFTLPNSTFRNDLGLPSNATYSTFSPREQTAGQDSTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1QHU0</accession>
    <name>N1QHU0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ZIP zinc/iron transport family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_145963</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764937.1">
        <property type="nucleotide sequence ID" value="XM_016903371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QHU0"/>
    <dbReference type="STRING" id="692275.N1QHU0"/>
    <dbReference type="GeneID" id="27900508"/>
    <dbReference type="eggNOG" id="KOG1558">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027089_0_2_1"/>
    <dbReference type="OMA" id="HHHGHFN"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000007">
        <property type="term" value="F:low-affinity zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071578">
        <property type="term" value="P:zinc ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004698">
        <property type="entry name" value="Zn/Fe_permease_fun/pln"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00820">
        <property type="entry name" value="zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF69">
        <property type="entry name" value="ZINC-REGULATED TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="49"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF16816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="361" mass="39195" checksum="7438A15DEB90AE54" modified="2013-06-26" version="1">MSECDAGNEFDGRLGLRISSIFVILVGSALGAVFPVYASRHRGTGVPEWAFFIAKYFGSGVIVATAFIHLLAPAEEALTSNCLTGPITEYTWVEGIVLMTIFLLFFVELMTMRYAKFGHSHDHDAAHEASGQDKMLELNSSVTSVRYLDEPHVKNDSGNDCPTNPHVPGDDHLSHAREHQGSALGTTVQTHKTFDPESYAAQMTAVFILEFGVIFHSIFIGLTLAVSGSEFDTLYVVLTFHQTFEGLALGSRLGSIEWPESKRLTPYLLALAYALSTPIAIGVGLGVRTALNTNSQSFLIVNGVFDSISAGILIYTGLVELMAHEFMFSSYMQRAPIRMVLSAVGCMVLGALLMAVLGKWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1QI04</accession>
    <name>N1QI04_SPHMS</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">SEPMUDRAFT_119313</name>
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    <organism evidence="2 3">
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        <name type="common">Poplar stem canker fungus</name>
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        <lineage>
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            <taxon>Mycosphaerellaceae</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758909.1">
        <property type="nucleotide sequence ID" value="XM_016901499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QI04"/>
    <dbReference type="GeneID" id="27898636"/>
    <dbReference type="HOGENOM" id="CLU_723944_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF10788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="382" mass="44562" checksum="65E9F7DD143EEB7D" modified="2013-06-26" version="1">MRLKKKPRILTRPYWRHLFERAQSKLNTTPAQEQLDERFKNLPAELRLEIQEHYLRADPIRVGDDGELRHPLVDKNVTCPDLRETAALYRAAPIVLSYYLLKTGQHGRYYFDLDSSSKPWAPYSYFLEHHDRHLGRAHRKHLRLEIRITIPSNCYKKLRFRCDELGRVTFQPGHEHACRSRHCERPEQQVNVWRHIDTHTNRISEHTEIPRENINTEVAFVHYKCQACGCAHARCKLKLMCMGPPYMVLCLMAYVVISWQTAYCGWDIYKKWRAQIRLQPGIHRYTLYASFLLPVFLGGVFLTPLAMPLKWTVQGSEKAAQMVVQIIERRQTARKAMKQRIRADAEAVAATDASRKQGTVSAVQLGSFPFENRPSEPMIGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1QI18</accession>
    <name>N1QI18_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_104170</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">Poplar stem canker fungus</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016900532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QI18"/>
    <dbReference type="GeneID" id="27897669"/>
    <dbReference type="HOGENOM" id="CLU_1046506_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF16840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="266" mass="29011" checksum="6102DBB1504C44A1" modified="2013-06-26" version="1">MLPEIKLDASCIRASDLVKVGRSGLPCKLSAHGKLVVTLEFDDGDDGDGGGDDDDGDEWMIEIRTITSIHCSWTGGGPAAHWSLLSLALADEWWQQAATGICAARGEMVAVGWMESKLETASRRGRWQLETKKLFSTTITTTTTTTTPIRAHCPRRHYTPRCLSVPGRLCFAALVAPLLTADIERPAHHQASGENINALPFRLSTFELPPSVRPTTPSRRARTSQPQCTAPQSQVLYSCAPSAEHANPQALQQRHRRAVRAIHTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1QI39</accession>
    <name>N1QI39_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_151581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757750.1">
        <property type="nucleotide sequence ID" value="XM_016906905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QI39"/>
    <dbReference type="GeneID" id="27904042"/>
    <dbReference type="eggNOG" id="ENOG502S621">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047721_1_0_1"/>
    <dbReference type="OMA" id="RVHRTCH"/>
    <dbReference type="OrthoDB" id="5370011at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="400" mass="44673" checksum="A307D9407175B20D" modified="2013-06-26" version="1">MTEDASTPPSMADRERRRGSLARRALQSVRAVMNRRSSGIRSPTASSSAEVRNVAAVRIVEPTSSASVGAERNDIPGSVIEDVGPIRAVEAPVVSLAAMRNTIEVDNSDDDETVEPLLPMRMGRSGLSTEKARELFAQHGFHYELRGFQPHQEPPNKIRRVEKPIRLRVHYTCHECQRKFGVEKTCLQCGHQRCRVCARDPPRRVKELSDRSRKSMQADEAAKATAAAVASTETCAKVPAIEPAVPAPESAPEMLTGPLLLDESSEYTTEPLPKDFEFTMYARPRTGIQTMWRADSRPRVHKQSHSASLTSSEDDVPMVRTVKRVYRKPRQRVRYTCENCSTLFIEGVRCYQCGHERCQHCHREPPKRTPPQHDPEVMRSLAARIASYNYGQSSGVTASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>N1QI53</accession>
    <name>N1QI53_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">18S rRNA factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_26945</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the small subunit (SSU) processome assembly and function, and in the 18S rRNA synthesis. Required for the early cleavages at sites A0, A1 and A2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESF2/ABP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757765.1">
        <property type="nucleotide sequence ID" value="XM_016908420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QI53"/>
    <dbReference type="STRING" id="692275.N1QI53"/>
    <dbReference type="GeneID" id="27905557"/>
    <dbReference type="eggNOG" id="KOG3152">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054086_0_1_1"/>
    <dbReference type="OMA" id="TRKHNDF"/>
    <dbReference type="OrthoDB" id="287393at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034462">
        <property type="term" value="P:small-subunit processome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd12263">
        <property type="entry name" value="RRM_ABT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039119">
        <property type="entry name" value="ABT1/Esf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034353">
        <property type="entry name" value="ABT1/ESF2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12311">
        <property type="entry name" value="ACTIVATOR OF BASAL TRANSCRIPTION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12311:SF7">
        <property type="entry name" value="ACTIVATOR OF BASAL TRANSCRIPTION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="225"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF09644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="269" mass="30848" checksum="C41056AF81D92EFF" modified="2013-06-26" version="1" fragment="single">MSVRKRNEYLEGDESDDEIGNGYDSEAEEGRGAIANKRRKLDREQDDPSDISSDEAEPPAQATKTAPTDSRFDVSQFLAEDEHPTSQISDKPPKKKSKDLKAYEAAHKKAKKSGVVYISRVPPFMKPQTLKHFLEPHAPHGLGRIFLTPEDHTQHTQRVKNGGNKKKSFTDGWVEFTSKKEAKLAAEQLNGNIIGGKKGGFYHDDLWNMKYLRGFKWEHLTEQINNENAERAARIREEVRRTRKENRQFVEDVERGKMLAGMERKEKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1QI60</accession>
    <name>N1QI60_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aldehyde dehydrogenase</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_151596</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757775.1">
        <property type="nucleotide sequence ID" value="XM_016906917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QI60"/>
    <dbReference type="STRING" id="692275.N1QI60"/>
    <dbReference type="GeneID" id="27904054"/>
    <dbReference type="eggNOG" id="KOG2450">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_0_0_1"/>
    <dbReference type="OMA" id="WSNTFNK"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019413">
        <property type="term" value="P:acetate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07091">
        <property type="entry name" value="ALDH_F1-2_Ald2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000050">
        <property type="entry name" value="Aldehyde dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000001">
        <property type="entry name" value="Mitochondrial aldehyde dehydrogenase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="8">
        <location>
            <begin position="28"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF09654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="498" mass="53893" checksum="DEB390B8A01AEC16" modified="2013-06-26" version="1">MSDLSVQLETPSSGKYTQPTGLFINNEWVKGVDGKTFEVINPATEEVITSVHEATEKDVDIAVAAARKAFEGPWRQETPENRGKLLVKLADLFEKNLELLASVEALDNGKAQSMAKVDISMSAGCLRYYGGWADKIEGKVVDTTPDTFNYIKKEPIGVCAQIIPWNFPLLMWAWKIGPAIAAGNVVVLKTAEQTPLGGLVAAQLIKEAGFPPGVVNVISGFGKVAGAALSAHMDVDKVAFTGSTVVGRQILKAAAGSNLKKVTLELGGKSPNIVFEDADIDNAISWVNFGIFFNHGQCCCAGSRIYVQEGIYDKFLARFRERAAKNVVGDPFAKDTFQGPQVSQVQFDRIMSYIKAGKDAGANVEIGGNRKGDKGYFIEPTIFSNVTEDMQIVQEEIFGPVCCISKFKTKEEVIKVANNTTYGLAAAVHTKNLNTAIEVSNALKAGTVWVNTYNTLHHQLPFGGFKESGIGRELGENALDNYIQHKTVSIRLGDALFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJ61</accession>
    <name>N1QJ61_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Malate dehydrogenase</fullName>
            <ecNumber evidence="3 12">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SEPMUDRAFT_149688</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="3 12"/>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759946.1">
        <property type="nucleotide sequence ID" value="XM_016905709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJ61"/>
    <dbReference type="STRING" id="692275.N1QJ61"/>
    <dbReference type="GeneID" id="27902846"/>
    <dbReference type="eggNOG" id="KOG1494">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047181_1_0_1"/>
    <dbReference type="OMA" id="FGCAVEL"/>
    <dbReference type="OrthoDB" id="4069699at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01337">
        <property type="entry name" value="MDH_glyoxysomal_mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000013">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.110.10:FF:000001">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001252">
        <property type="entry name" value="Malate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010097">
        <property type="entry name" value="Malate_DH_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01772">
        <property type="entry name" value="MDH_euk_gproteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540">
        <property type="entry name" value="MALATE AND LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540:SF16">
        <property type="entry name" value="MALATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00068">
        <property type="entry name" value="MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 12" id="KW-0520">NAD</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="13">
        <location>
            <begin position="3"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="14">
        <location>
            <begin position="149"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="8"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="119"/>
            <end position="121"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMF11825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="332" mass="34618" checksum="DAA5AD825A73CC0D" modified="2013-06-26" version="1">MVKAVVAGASGGIGQPLSLLLKACPLVDHLSLYDVVNTPGVTADLSHISSIATIDGYLPDGGEGIKKAFKGADIVVIPAGIPRKPGMTRDDLFKINAGIVQGLVQGIAENCPDAFILIISNPVNSTVPIAAEVLKKAGVFNPKKLFGVTTLDVVRSETFVQSLTGEKDPSKTVIPVIGGHSGETIVPLFSQAKPAVKIPEDKLDALTHRVQFGGDEVVKAKDGAGSATLSMAYAGFRFAEKVIRAAKGESGIVEPTFVYLPGVAGGDEIVKETGLEFFSVPVELGKDGAAKAVNIVKAANEYEKKLLTKCYEGLKGNIEKGIDFVANPPAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJB1</accession>
    <name>N1QJB1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Lysophospholipase</fullName>
            <ecNumber evidence="2 9">3.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_145634</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the lysophospholipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="2 9"/>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764498.1">
        <property type="nucleotide sequence ID" value="XM_016903172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJB1"/>
    <dbReference type="STRING" id="692275.N1QJB1"/>
    <dbReference type="GeneID" id="27900309"/>
    <dbReference type="eggNOG" id="KOG1325">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014602_0_0_1"/>
    <dbReference type="OMA" id="FASCLAC"/>
    <dbReference type="OrthoDB" id="4084751at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002642">
        <property type="entry name" value="LysoPLipase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728:SF33">
        <property type="entry name" value="LYSOPHOSPHOLIPASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01735">
        <property type="entry name" value="PLA2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00022">
        <property type="entry name" value="PLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51210">
        <property type="entry name" value="PLA2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8 9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6 8 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005141854" description="Lysophospholipase" evidence="9">
        <location>
            <begin position="20"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="PLA2c" evidence="11">
        <location>
            <begin position="40"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="543"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="550"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF16377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="602" mass="62626" checksum="539B02F3A0C1D24C" modified="2013-06-26" version="1">MHVHLLPAVFAALVTAVSARQLVPAKRQAAANPYVPTATSCPTSLIRSADSSLNADEQAYIEQRTPKAASALLAWLAQALQGLSTEQLPTLALALSGGGTKAGMTTAGAVYGLDGRENSNSPVAGLLQSMTYISALSGGSLTLSGVMANNFEKISTLRTALLDESYQNAVAAPLANAAAVREDVGNKSAAGFPTTLLDAYGKTISYNYISSSGGNDLHWSDITSQSSFQDHEAPYPIITITQANVAENMCDPNNDSAIWEISPAEFGSFDEMVGAFYPTMYMGTKNSDSIGECIVGFDNAGFLSAISSNILIPTNDVCTIGNFTSSEFNNTLATLISTLFPNISSSNPYGIIPNPFYQSSEAGIIRSQENIYGTDGGYSGQVIPIFPWLQPARAVDVIFVVDATTALPTNITNGTSVYETYLSAQKKGLPRMPLVPTPDQLVQQNLTSRAQFYGCHDPSVATLIYLPNTELADAPTEFLATPEQINSTIAGGTAMVTQSQSADDSAAEWASCLACAIVHKNVTTALPDVCTGCLEKYCWPTENGTDSSSPGGGANTGGGGGGSGTGPINGTIPYTGTAAVTKHSVGTASAVGLVGLIFAMIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJV3</accession>
    <name>N1QJV3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ketoacyl-synt-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_77864</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765637.1">
        <property type="nucleotide sequence ID" value="XM_016910176.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.N1QJV3"/>
    <dbReference type="GeneID" id="27907313"/>
    <dbReference type="eggNOG" id="KOG1202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_6_3_1"/>
    <dbReference type="OMA" id="CASDYND"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041068">
        <property type="entry name" value="HTH_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF21">
        <property type="entry name" value="NON-REDUCING POLYKETIDE SYNTHASE AUSA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18558">
        <property type="entry name" value="HTH_51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="8">
        <location>
            <begin position="357"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="9">
        <location>
            <begin position="1257"/>
            <end position="1566"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="1620"/>
            <end position="1697"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="1748"/>
            <end position="1822"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="6">
        <location>
            <begin position="1257"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="6">
        <location>
            <begin position="1411"/>
            <end position="1566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF17516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="2240" mass="244275" checksum="F1422BCA52B02A6F" modified="2013-06-26" version="1">MRLQTTLKETQTLKPIADALRELPLLWDSLTCSDTALHASSGKAAATNLAHWITRETGEHLSLEEERNALMMPMAVISHVIQYLEYLKLREGGAAHSAVLESVTNGGGVQGFCAGLLSALAVASAKSEEDIGVYAASSVRLAFCIGAYIDFDQASSFGFTKLAVRWPATTSRETIEDLLATYQETYIAVIRDERDATITCPVSVACSLRQELARSNISVRDTGLPGRYHTQVHTGIPERILKACEGRLQPPFVHTGLVRSNTDGATLPDDDNATIVALRSILEERANWYLTISAAATALSPTGERSCILAVGLDAVPSSVAKRFATQRMSANSSDVRVGQPKFGAVPEVSETDCYPAGAIAVTGMACNFPGAESVDDFWDLLKTGRSMLSEMPPERFQPGESSRSKEDLKFMGNFIDDIAGWDHKFFRKSAREAASTDPQQRHLLQVTYQALQDSGYFANPSRPRDIGAYIGACSADYDFNVASHPPTAYSTVGTLRAFLSGKISHYFGWSGPSLTFDTACSSSAVAIHTACKALQTGECSQAIAGGATLLSSPYLYENLAAAHFLSPTGATKPFDVSADGYCRGEGIGVVVLKRLDDAIADGDFIRGVIVGSAVNQNSNCVPITVPHAASQAALYRKAAQQAAIDPKTVDFVEAHGTGTPVGDPIEMESIRDVFGSVDERTSTLFVSSVKGAVGHLEGASGVASLIKAVLQMEHRAVTPQASFTRLNPRIPPLAPHRMCIPTSLQKLDGHRLTACINNYGAAGSNATLMLAEAPRQPQRLLPEKSAICSKYPIRLCAASPSSMIASCKSLDRFISRWLASHTLIEHSHLLPSLAYSLSRHEDQQLSHMVTFAATPTDIGQLQSHLRKRCMDIHSVIETPKEPPLVLCFGGQGADAIALDRRVWQVSALLRSHLDRCHELLCEMGYPGIYPYIFQTEPVTNVIAHNSILFAMQYACAQSWIDSGLKIDALVGHSLGQITALSVSGVLSLRDGLKFIAGRAALMLKYWGAEPGSMVVLDAAESTTHEIITALQERDPNLQYEVACYNGPKCHVVVSDRASAAVLIEEASKRAVRHKQLALQYGFHSRFTDALFPHLERLAESLEIHPPEIHLESCSPNSAWERPTAKLIAAHTRDPVYFKQAVQRVHDRLGPCTWLEAGSNSTVIGLTARIVGATDGSKFVPTALNKTTSLEQLTDVTINLWNRGHRLQYWNFHHSQQADYEVLRLPPYAFDKHRHWLDLVVHRPETPNTQSCEPMLPPALPATLISLERSDMQGHHFIINPSSQEYQSIAKGHNVLGTSSCPPSIYIDIAARAALLTGHNGLDSVLPEVTGLRIGTSMRLNVEGSVKLLLEAMGTSWKFTIFSMHANHKTLHHASGTVSLQKQNQELEKDFTRFEMLASRSNIAAIRSDPIESLQGTMVYKLLSSLVDYAESYRGVRSLATRGNQIAAKVVLPKALGNHLHDASIINTAFCNYFTQVAGIYANFMCDSPAGSISKLASIDVVRTGPSYRPLREEGFSEAVYDVLAYATPSTGSVASDIFVYEAATGRMVLYILGAVFVVIEDPAATTKFPSPVTNEEPTSRRQQVIATTPMNLQPAKSAPDEAKCTVRELAVPHHRSSPDPKSVVQAEIVRILEDIAEINPATVHGDSKFESLGLDSLMIMEVIGELSSTFRIDLPLDELMELIDVEALSKYLTSRGCGRSHDVHLESDQGTQCGSSSASPVTMTVSGSWASAYQPTSPASESPPPTIDVSRRLSLLICEHLELDNMQLSGEENLADLGLDSLVAIEIASDVKRQFSVEIDMEELDDRSTFADLLRLVTGHVMLPGPTTTSRPQPSQCQASPWNRSDSVHMLSTIELAKPDVVTASRAFESVKLSFDYYANDTGFVGFWSKVYPDQSELVVAYVIEAFEQLGCNLRDLSAGERLSTMKVESKHQHLLERMHVILADARLLETRNNSHFRTSTPLSGRPSAELYAAMLDRHPQHASETKLLHVTASRLATCLTGSCDPLRLLFADPTAKQTLSDVYESAPMCLATTRLLGDYLQKKVSAFTDSESGSKARPFRVLEVGAGTGGTALYLVEHLQSLNVDFEYHFTDISGALVSAAKRKFRSLPSTVAANMHFGTLDCNNPCPPSLSGTFDVVIATNCIHATPHASRSCANIKDLLMEDGVFCLVEFTRSLYWFDLVYGLLEGWWLFDDGRVHALADEKFWEKSLKNAGFEEVKWTDGDSAESQTMRLICAFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJX9</accession>
    <name>N1QJX9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_118060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760236.1">
        <property type="nucleotide sequence ID" value="XM_016901399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJX9"/>
    <dbReference type="STRING" id="692275.N1QJX9"/>
    <dbReference type="GeneID" id="27898536"/>
    <dbReference type="HOGENOM" id="CLU_311499_0_0_1"/>
    <dbReference type="OrthoDB" id="3640238at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="524"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="694"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="768"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="874"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="768"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="817"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="898"/>
            <end position="920"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF12115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="943" mass="101401" checksum="E8449D91B2D8205A" modified="2013-06-26" version="1">MSLNPTQATGLNHCQADSLHESSASAVAECLVDLSAFVYKGYCTGIIMLDLPILATAKNLSNRLYGYAFSLVIERSPGFLTRPGQNTSLNTSRAVDSMSQLAAFLENKAHDLEVCGFANGHEVALAEDLRFFEQYTRMLLQTAPSRLKAVDSSAPPINASIKVPEGRALSEKSRGKAAEAQPTGSDEPGRDAQDISGVEHIAFEYNVTQAIEAPLPSPGTVMGQSLKYNNHPTDVSSDIRRPTHLDIPPLESGATTPAGATTPYDLRPTPFNVEHAPHPLQGSRLWSPSCIADNEAFSRLHSGSDKTLRQTPNSCTTLQIGHSTEDPFQSRQYVDASTLGYTGIKALRLVHPFCAREIHELNFDVLRFLDVVLGERVVARAVEMEHVSAKRERAANRALRKSREIVEREIGIRNWEINRAPPQPHSTASDDRAEALHSQPTSAVHECHASESVAEGLEAATPPPSHISWPGISLDPDDSASQHELLPLPVRKRLDTYSIHVEVPRGLQGPKDIHVRFADEAPADRLAGSASPARTSSSVPTELLRAPGGTGFGANRVDEVGSAAEVPVVETAQGPTKSSQIASNDRGPSVEQVQAQLTALQLQLANARPRERPRPEVSVYVRPNMPESPLQGSPSSIQGFHGDCECAFQPDGEHSSPLEETHCAVTVPTPDDSTVIHTIPKPVSTVVAAAAAAAQPSTLPTHPQAEATQWKEDTHTSNGRSSPPYVAYTKCEDEDGKLYILDTPDGKPICLETATAAATTTTSTCQQQQQQQNLTSNNSNSKKSSSSNILSNNSNDKPDISEIQHQMIKSPDEQEQQHQSSKHTSNSPPLLLFFSPVQDFNSPDELSSAPVPDLALLALEAQIPRSDTAATQSLAAGLKSSRGRGRVERGGFATVGEDSGDDDDGEYSGDDDDDDGGGGDEEWRRLGFVEAGCSSRGRMSFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1QK68</accession>
    <name>N1QK68_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">SUN-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_146600</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SUN family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765752.1">
        <property type="nucleotide sequence ID" value="XM_016903759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QK68"/>
    <dbReference type="STRING" id="692275.N1QK68"/>
    <dbReference type="GeneID" id="27900896"/>
    <dbReference type="eggNOG" id="ENOG502QPVV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033459_1_0_1"/>
    <dbReference type="OMA" id="CSYACQS"/>
    <dbReference type="OrthoDB" id="5339822at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051526">
        <property type="entry name" value="Beta-Glucosidase_SUN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005556">
        <property type="entry name" value="SUN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31316">
        <property type="entry name" value="BETA-GLUCOSIDASE-LIKE PROTEIN NCA3, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31316:SF0">
        <property type="entry name" value="SECRETED BETA-GLUCOSIDASE SIM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03856">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110912" evidence="12">
        <location>
            <begin position="17"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="75"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="100"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF17631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="451" mass="46597" checksum="399F3F93C5CD939B" modified="2013-06-26" version="1">MKLSIALLQAAVVVSAAQQAHHHGHQHLHQEKREPQAPAGYESVDVPTQVVYVLNGHPISETEVQQGINNGTLVFADGSLSDAPPSYEEPPPSYGPPPSSSSSSTSTSTSTSSSSTSSSSSSSTRISTSTPAPTTSVSKPTPTPKASTPPPSPPGPPPKPSPPGYGSGGGSGVDADFPDGTLSCEHFPSEYGPIPVEWTGLGGWTGVQCPGAGSDSTGFTNIETVTPGGTCREGAYCSYACPPGYTKTQWPLLQGMTGQSVGGVLCQNGKLHLTNPDLSKKLCMKGTDKVQVLVKNKLPKNVAVCGTDYPGLESETIPTDVGPGETKNLTCPDAEKAYKWQGRSTSAQYYVNPAGVPVEKACCWGTPDNPWGNFAPMNLGVGYSNGAAWLSIFQNAPTTNAKLEFTVEIVGDTLSGSCKYSDGQYCSGTSCSPVTGCTVSLSSGTATFVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2023-02-22" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKH4</accession>
    <name>N1QKH4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_149613</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759822.1">
        <property type="nucleotide sequence ID" value="XM_016905662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QKH4"/>
    <dbReference type="GeneID" id="27902799"/>
    <dbReference type="HOGENOM" id="CLU_2559768_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF11701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="82" mass="8773" checksum="BDD8A30356E76705" modified="2013-06-26" version="1">MTTGAFFSDRLPDRFHAANMCDLAWSWMIDFSSPVVSGKAGAVAHGKGIKVRSTHGNSRPGLCRTTEMHCGGFSLGFGRAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKN8</accession>
    <name>N1QKN8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription initiation factor TFIID subunit 1 histone acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_146708</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765866.1">
        <property type="nucleotide sequence ID" value="XM_016903812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QKN8"/>
    <dbReference type="STRING" id="692275.N1QKN8"/>
    <dbReference type="GeneID" id="27900949"/>
    <dbReference type="eggNOG" id="KOG0008">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000572_1_1_1"/>
    <dbReference type="OMA" id="RFINYYR"/>
    <dbReference type="OrthoDB" id="5752at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040240">
        <property type="entry name" value="TAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022591">
        <property type="entry name" value="TAF1_HAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12157">
        <property type="entry name" value="DUF3591"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 1 histone acetyltransferase" evidence="4">
        <location>
            <begin position="455"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="30"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="356"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="869"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="913"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1053"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="136"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="876"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="923"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1053"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1071"/>
            <end position="1087"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF17745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1165" mass="130362" checksum="3F109AA65DA95FFF" modified="2013-06-26" version="1">MPHAIEDEAMGGVDEDAAVAQYLREHEEGFEAADLQFDQTDKADDAVDYEDFSDDDLPEEQEPEGKIEESTEDGYLLRQLGDFNAQSEQPATSGLHDLSEHDLFGETDENNDLFGEHLSSPEVERHAPLSTAQQQPSGLALPSKSALALPTYQPMRKSSQASSSSISPPPFPDRGYAALSPTSMTSEDEDHDLDPQVVLQRSLFKASKLRTAGDDEDHLSREPDWHTFYSLYPGYEKSQAPRFVDLFPPRAVEFKGKAPLKPPRVIVPTKLSLDLLHDQERGFKALAASNKSKQDSTFNNSLVPLANRYTADSESDDELTFSELDETERVGNLTMHDLALICQDWEIPSIHSDAESQADIDTDTTQGDWDLNEQARPNKRRRVDALRPSALRELHFSFEYPERTTAKLAKSVALDLNDPHLLIDEHAPQTKRKLQRVPGDSKRDSAVNRDLAKRYNISNDQAYDLLKENHQHKVRSTLGSMAVEHSYPAAKLQFPFYKVNLDPKAKRAFHRPHLELKQQPGTREYRFTKPKHIKRKHVRGREAKEVFAKAEDLSLGDSASMLLLEYAEEAPMMLSNFGMGNRLINYYRKQHADDQERGEKKDIGEAQVLLTQDKSPFSNFGHVDKGETVPTLQNGLYRAPVFSHAPKQTDFVIGISSTYEGGDRFFLRNVENLHAVGQQFPFAEVPGQHSRRVTDAAKKRLRALSYRIYTKSLTRRDKVLDNASLMPHLPGHDMPQTRSKMREFMKYERVTTRGDGSTGVWVPQPGHPVPDAETLRGWIRPEDVCLLDSMQVGVQHLTDLGISEGDKGEEEKDIDEGANIELQLAPWRASKNFLNACQGKAMLKLHGDGDPTGQGLAFSFVKTSMKGGFQAQGESVEDKIDKQKRRDTGGHSYNVAKQQKQYDESIRRIWESQRASLQKPEEISDDDMEDEPDRSAEYNSGRVHTPRSSVGTPAAFSGRHDDDYMSQFSGHSASRGDRALVITRSQGIDQFGQPLPEVTETITNPAVIREYRKRALQKEYANADMNKIVPTGDSERDAFARRELEKELARVKRNRERREARDRLKARQRDPTAANSPTAAAASPGPSDMDGPASTIDGVAETNTPQRAKGRSKDGTARKCANCGQVGHIKTNRKLCPMLNGTMKSEDAGLNGDSSFGAVPAPLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1QL62</accession>
    <name>N1QL62_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Nascent polypeptide-associated complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SEPMUDRAFT_146137</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SO2202</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="12">Part of the nascent polypeptide-associated complex (NAC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the NAC-beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765148.1">
        <property type="nucleotide sequence ID" value="XM_016903473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QL62"/>
    <dbReference type="STRING" id="692275.N1QL62"/>
    <dbReference type="GeneID" id="27900610"/>
    <dbReference type="eggNOG" id="KOG2240">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098726_2_0_1"/>
    <dbReference type="OMA" id="AGDTYME"/>
    <dbReference type="OrthoDB" id="8033832at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005854">
        <property type="term" value="C:nascent polypeptide-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22055">
        <property type="entry name" value="NAC_BTF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.30:FF:000003">
        <property type="entry name" value="Nascent polypeptide-associated complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.30">
        <property type="entry name" value="Nascent polypeptide-associated complex domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039370">
        <property type="entry name" value="BTF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038187">
        <property type="entry name" value="NAC_A/B_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002715">
        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10351">
        <property type="entry name" value="TRANSCRIPTION FACTOR BTF3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01849">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01407">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51151">
        <property type="entry name" value="NAC_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0678">Repressor</keyword>
    <keyword evidence="10 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NAC-A/B" evidence="14">
        <location>
            <begin position="33"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="121"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="133"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMF17027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="156" mass="17024" checksum="9E5F45D9C70707DA" modified="2013-06-26" version="1">MDMDKLAKMQASVRIGGKGTPRRKVKKVHKSSGADDKKLQTVLKKMNVQPIQAIEEVNMFKSDGNVIHFSAPKVHASVPSNTFAIYGNGEDKELTELVPGILNQLGPDSLASLRKLAESYQSLQKGGEGEASKEDDDDEIPDLVEGENFEGKNDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1QLG1</accession>
    <name>N1QLG1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exocyst complex component Sec8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_149848</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SEC8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760187.1">
        <property type="nucleotide sequence ID" value="XM_016905809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QLG1"/>
    <dbReference type="STRING" id="692275.N1QLG1"/>
    <dbReference type="GeneID" id="27902946"/>
    <dbReference type="eggNOG" id="KOG3691">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004025_0_0_1"/>
    <dbReference type="OMA" id="HMEVRCR"/>
    <dbReference type="OrthoDB" id="272977at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090522">
        <property type="term" value="P:vesicle tethering involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039682">
        <property type="entry name" value="Sec8/EXOC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007191">
        <property type="entry name" value="Sec8_exocyst_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048630">
        <property type="entry name" value="Sec8_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14146">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14146:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20652">
        <property type="entry name" value="Sec8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04048">
        <property type="entry name" value="Sec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="3 4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec8 N-terminal" evidence="6">
        <location>
            <begin position="96"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex component Sec8 middle helical bundle" evidence="7">
        <location>
            <begin position="344"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF12066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1035" mass="116363" checksum="DA726707AE000CAF" modified="2013-06-26" version="1">MASFRNGYLNGSGDSPLMRFNFDNDSSRDNSDAERSRSRGAPPPKGFHTGAARVRGIGRGGLDRGHAQRRSRDYDQSQSRSRSRTAARYGSASGQVDDILRFIEQQWSFMATDNCIPVKVALQLMDNSSLGLADQSQQFGEAHTQLQNALKVIVNEHHQGFNSSIGTFHKIQAAIHSSQVRVRNLRAGLVQAKSSLATTRPELRAFAHSSQSYDQMLQVLGTIEQLQQVPEKLETQISEKRFLGAADTLQDALKLMRKPDMEEIGALSDLKVYLSNQEHSLTDILIEELHNHLYLKSPYCEERWKAHTRQDPTSTTIDDGERAMFEFLDSFDATKPMLEDTTRNPEADTFYYIQLLVESLNRMNRLENAVDAIEHRLPVELFTVVERSHMEVEQRHPAVMRSAAKLQRNAMGITWGADGERKETLEDLLTTLYAKYEAIAEGHRVFHDVMAAIIERDDHDESAGLNRSFRELWKLLQSEIRSLLHDHLATNGNLGQRTRQENDPNMNIFHQQPRDRSRRLFKLSEADNKSTELATERDDLEAILKQSVPGLVGSNAQNAKQDRNTVTDISATGHKLLVEPSVFNMGILLKPSLDFLTRLRGVVPPQSGVVPSTLTSFLDDFLINVFYPQLDETLLDLCERNMTEMDAFQTDPKWQSLAQRPIFKGTTRFYELIEAFCIMLDSLPHDQSFSQLIVTQMRTYYDKCYQWSRGLLQRALVENGNTKMRLAAHLATDGEVNKVVIELSRKDVNDPIVLAEKETALLLRQVKNTRLEEADLIVDRKAISALCTLHTSMKWLSAQCKQLRYVSPRAIDTSSMQAHERRRWTQISIAGSAPNGPYLPLDQQTAAGFDAVIASFTEVASLILRTLHIDLRLHLLHGIYTALDTTYALGQPYNDPDPAILHLSASLGTYDSAISANLLPPQYNFLTANLHVLANNALVSLVGCVQALDEYGLDRMGLNILVLQQTLKASMQQDASLKYAARFYEMREPATIAAAGTQSGYAPEDLKTLARLVWVEKRDRGSGNGTLDELVANIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1QMH6</accession>
    <name>N1QMH6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Nucleolar GTP-binding protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_77922</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Nucleus</location>
            <location evidence="2 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765668.1">
        <property type="nucleotide sequence ID" value="XM_016910179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QMH6"/>
    <dbReference type="STRING" id="692275.N1QMH6"/>
    <dbReference type="GeneID" id="27907316"/>
    <dbReference type="eggNOG" id="KOG2423">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011106_4_0_1"/>
    <dbReference type="OMA" id="RTQGFNH"/>
    <dbReference type="OrthoDB" id="444945at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000200">
        <property type="term" value="P:regulation of ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01858">
        <property type="entry name" value="NGP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000559">
        <property type="entry name" value="Nuclear/nucleolar GTPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024929">
        <property type="entry name" value="GNL2_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012971">
        <property type="entry name" value="NOG2_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050755">
        <property type="entry name" value="TRAFAC_YlqF/YawG_RiboMat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089">
        <property type="entry name" value="GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089:SF9">
        <property type="entry name" value="NUCLEOLAR GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08153">
        <property type="entry name" value="NGP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="9">
        <location>
            <begin position="230"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="509"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="514"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="549"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="591"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF17547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="607" mass="68024" checksum="ECF915863829E819" modified="2013-06-26" version="1">MGSGKKEAARKVRQGKTGDGMGNVKTKGENFYRSAKKVKTLNMFKEGRATRNAKGEITQTASFQSWDKPSARVEPNRKWFTNTRVISQDALDKFRGAVEAQSKDPYSYLLKQNKLPMSLITDNKDKERKDGLIQHKAKIRIESEKFGDTFGPKAQRKRPRLAVSNIEDLANASGKDYSTYEERLEEARLLSGAGDIQPDTGFTGDEDYKNGELTTAREPVFSKGQSKRIWNELYKVIDSSDVIIHVIDCRDPEGTRCRSVEKYMREEAPHKHLVFLLNKCDLVPTSVAAKWVKILSREYPTLAFHASMTNSFGKGSLISLLRQFSSLHSSRKQISVGFIGYPNTGKSSIINTLRKKKVCTTAPIPGETKVWQYITLMKRIYLIDCPGIVPPSITDTPEDILLRGVVRVENVENPAQYMPAVLAKCKRHHLERTYQISKWNDDDGLKPFEDKDEKERLTESINFLEMLARKGGRLLKGGEADMDGVAKMVLNDFLRGKIPWFSAPPKQAGEELLESTKEGSRDEKLGLTHKRKRDLQDDGSVATSAAEGKEEEEEEEEGEDDDDVDDTFTGFDEDGEEDESGIPIASGQGDSADDDSAEEEDEADASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1QMU0</accession>
    <name>N1QMU0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">t-SNARE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_145981</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764970.1">
        <property type="nucleotide sequence ID" value="XM_016903386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QMU0"/>
    <dbReference type="STRING" id="692275.N1QMU0"/>
    <dbReference type="GeneID" id="27900523"/>
    <dbReference type="eggNOG" id="KOG0810">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042423_0_2_1"/>
    <dbReference type="OMA" id="HPRNAPQ"/>
    <dbReference type="OrthoDB" id="10255013at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15849">
        <property type="entry name" value="SNARE_Sso1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF380">
        <property type="entry name" value="SYNTAXIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00804">
        <property type="entry name" value="Syntaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="5">
        <location>
            <begin position="212"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="137"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF16849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="329" mass="36563" checksum="5FE2A8802974EC26" modified="2013-06-26" version="1">MAYNNTTSYGGSGYGSSNPYDTDGSYGNPPPAYGGGVEMQPLTHNGAPYSSTPEPRRDPNQILNDCRAVGRAIDDLESRLQELQRLQRTFVSSAGVSNKDVDALSADIMSGYRGLADRVKRIKGQPDAGNPRNKPQVEALDRRIRKAIQSYQQTEAAFRKEVQEQQRRQFLIVRPDATESEIREATESGGDTQIFQQALMQSDRRGQSQSTLRNVQQRHDAIQQIERTMIELQQLFQDLDAIVVQQDVAVQDIEVKAEETYNHIEAGNVHLDKGVSSARAARKKKWICLGIVVAIILVIVLIIIIYGATAGGWFKSNNNNNNNTNNTTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1QN06</accession>
    <name>N1QN06_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome biogenesis protein RLP24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_33042</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765938.1">
        <property type="nucleotide sequence ID" value="XM_016908524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QN06"/>
    <dbReference type="STRING" id="692275.N1QN06"/>
    <dbReference type="GeneID" id="27905661"/>
    <dbReference type="eggNOG" id="KOG1723">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089419_0_0_1"/>
    <dbReference type="OMA" id="TCYFCSG"/>
    <dbReference type="OrthoDB" id="10262490at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902626">
        <property type="term" value="P:assembly of large subunit precursor of preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.20:FF:000001">
        <property type="entry name" value="probable ribosome biogenesis protein RLP24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056366">
        <property type="entry name" value="Ribosomal_eL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792:SF8">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN RLP24-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="TRASH" evidence="5">
        <location>
            <begin position="6"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="155"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="185"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF17817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="208" mass="24728" checksum="FD3546A400A2D42D" modified="2013-06-26" version="1">MRIETCYFCSQPCYPSKGITFVRNDAKVFKFCRSKCHKNFKMKRNPRKLAWTKAFRSAHGKEMPIDGTLANFAQRRNIPVRYNRDLVQKTLQAMSRVQEIRDRRERQFYKERMKGNKARQLEADRKLVAENQHLLPPQYRDQVEQALQEMPVEQVQEETMEEDMEEDMEEELPLEEQERLAPKKSALKQKKKQKMVRGKGVEAMDVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>N1QN88</accession>
    <name>N1QN88_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">EKC/KEOPS complex subunit BUD32</fullName>
            <ecNumber evidence="7">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="25 26">Atypical Serine/threonine protein kinase BUD32</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">EKC/KEOPS complex subunit bud32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="30" type="ORF">SEPMUDRAFT_58909</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30 31">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Chromosome</location>
            <location evidence="4">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. BUD32 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="7"/>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016766078.1">
        <property type="nucleotide sequence ID" value="XM_016909480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QN88"/>
    <dbReference type="STRING" id="692275.N1QN88"/>
    <dbReference type="GeneID" id="27906617"/>
    <dbReference type="eggNOG" id="KOG3087">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063953_1_0_1"/>
    <dbReference type="OMA" id="HKLYMEY"/>
    <dbReference type="OrthoDB" id="3399at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070525">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000603">
        <property type="entry name" value="EKC/KEOPS complex subunit bud32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000845">
        <property type="entry name" value="Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209:SF0">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT TP53RK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209">
        <property type="entry name" value="NON-SPECIFIC SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="22" id="KW-0010">Activator</keyword>
    <keyword evidence="19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17 30" id="KW-0418">Kinase</keyword>
    <keyword evidence="16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="20" id="KW-0779">Telomere</keyword>
    <keyword evidence="23" id="KW-0804">Transcription</keyword>
    <keyword evidence="21" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="14" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Protein kinase" evidence="29">
        <location>
            <begin position="16"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00019973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00030980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00033194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="EMF17957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="265" mass="29312" checksum="DE7A14AC5FFD4CFC" modified="2013-06-26" version="1">MTEHIHFLPPPFTNSPETFQLITQGAEALVYKTSFLSPDCPAALKIRPIKTWRHPTLDKRLTKQRITAEARVLVKCLREGIQVPRVLGADWEFGWLALEWIEGRTVKQVIRERKVGVEQDEEGLVGLLRRIGEVVGGLHAKGVVHGDLTTSNMMLRPATAIATSSPLPPPLRGNGEEESGQGGFSLEGDIVLIDFGLASQSATQEEDRAVDLYVLERAFGSTHPKEEELFSVVLTAYGSAYKGAKSTLKRLEDVRMRGRKKSMLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNG0</accession>
    <name>N1QNG0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acid protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_146695</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765849.1">
        <property type="nucleotide sequence ID" value="XM_016903803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNG0"/>
    <dbReference type="STRING" id="692275.N1QNG0"/>
    <dbReference type="GeneID" id="27900940"/>
    <dbReference type="eggNOG" id="ENOG502RV5I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009988_3_0_1"/>
    <dbReference type="OMA" id="DYDRQNF"/>
    <dbReference type="OrthoDB" id="4074350at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004111038" evidence="4">
        <location>
            <begin position="25"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="466"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="5">
        <location>
            <begin position="76"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="499"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="572"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="612"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="523"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF17728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="631" mass="67100" checksum="4E44A29B55960ED2" modified="2013-06-26" version="1">MKTAAPMRSALTTTLLTSPHLAAAAISSWSDIPSLLSRSVAGLERVAKRAENTTTIPAALSIAAAQNWDGNDGPWSSFPLQIGVQPQTVRAMIGTAVTSVLTVAAGGCPSFYPSNCETSRGQIFNTNESLTWVPNSIYDVGIEQNLGLDTSGSAGFDSVTIGWPGATQASVQRNVVFNLESPNFWLGIFGLNPRPTNFTTSSSSTTFNDPQPSFLQQLVNNRSIPSLSWAYTAGNQYRLDGNNLGSLTLGGYDESRYSPTKNLTIPFGSDISRDLLVNLRAITTDAGSPSNLLPDGNIQIFLDSTVSQLWLPESACTAFEEAFGLTYDSDFNFYLVNDTLHESLLSTNANVTFTLATAASGGQTMDIVFPYGAFDLTLEFPNIMNPNTSNYFPLKRASNSTQYTLGRTFFQEAYLIADYDRQNFTIAPCEWDATRIASQSIKSIIRANETSLADGGNGGSSNTGAIAGGVVGGVVGLVAIIGLILFLVRRKKKTERQRLAELDSKSASAAGGAAGGAAGGHSPETKTSTDTDGKPFISPPIGGELGGGEIHELTAPHKEAPAEMDSPYHVADPNKHGYSEMESSGTEFFAPSKGVPAEMRGETPIYEMAGSDVQELPAPRVNLSDRKVGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNL8</accession>
    <name>N1QNL8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Bifunctional cytochrome P450/NADPH--P450 reductase</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="16">Cytochrome P450</fullName>
                <ecNumber evidence="16">1.14.14.1</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">NADPH--cytochrome P450 reductase</fullName>
                <ecNumber evidence="16">1.6.2.4</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="21" type="ORF">SEPMUDRAFT_146431</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 16">
            <text>an organic molecule + reduced [NADPH--hemoprotein reductase] + O2 = an alcohol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17149"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:142491"/>
            <dbReference type="EC" id="1.14.14.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <cofactor evidence="16">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16 17">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">In the N-terminal section; belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.1" evidence="16"/>
    <dbReference type="EC" id="1.6.2.4" evidence="16"/>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765520.1">
        <property type="nucleotide sequence ID" value="XM_016903651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNL8"/>
    <dbReference type="STRING" id="692275.N1QNL8"/>
    <dbReference type="GeneID" id="27900788"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_7_0_1"/>
    <dbReference type="OMA" id="TQLVMKW"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070330">
        <property type="term" value="F:aromatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06206">
        <property type="entry name" value="bifunctional_CYPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11068">
        <property type="entry name" value="CYP120A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000040">
        <property type="entry name" value="Bifunctional cytochrome P450/NADPH--P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000198">
        <property type="entry name" value="Bifunctional cytochrome P450/NADPH--P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023206">
        <property type="entry name" value="Bifunctional_P450_P450_red"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF127">
        <property type="entry name" value="BIFUNCTIONAL CYTOCHROME P450_NADPH--P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000209">
        <property type="entry name" value="Bifunctional_P450_P450R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 16" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 16" id="KW-0274">FAD</keyword>
    <keyword evidence="5 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 16" id="KW-0288">FMN</keyword>
    <keyword evidence="4 16 17" id="KW-0349">Heme</keyword>
    <keyword evidence="12 16 17" id="KW-0408">Iron</keyword>
    <keyword evidence="7 16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 16" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 16" id="KW-0521">NADP</keyword>
    <keyword evidence="11 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 16" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="19">
        <location>
            <begin position="471"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="20">
        <location>
            <begin position="647"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="440"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="450"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="17">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR000209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000209-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EMF17399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1039" mass="115371" checksum="25A1735E1D341569" modified="2013-06-26" version="1">MALANLGKQYGEIFRLNIVGQNSAFVSSHALTNELCDEKRFHKLVSSSLAELREGVADGLFTAHDHETNWETAHRTLVPAFGPMNIKDMFGDMKDIASQLVLKFARHGSAYRISATEDFTRLTLDTLALCSMNYRFNSFYTEEEHPFVAAMVGFLKYASVRAKRPAWMRTFYSSDEAQWRSDIAYMRKLSGELVQQRRDNPKATNDLLNAMLNGKDPKTGNMLPAESIIDNMITFLVAGHETTSGMLSYCFYLLLKNPDAYRKAQEEVDRVVGKDSIQYEHLNKLPYITAVLRETARLHATAPAFTLTPRSPHGEVIGGKYFLAQGEPAVILLHNVHRDPAVYGDDAEEFRPERMLDENFAQLPPNSWKPFGNGARGCIGRPFAWQEMMLVLPMLLQYFNFSLDDPQYTLQTAFTLTIKPKDLVIRATLREGWTARKVEQHLNRSSDLETSTAKAHPTPTAPTTQDSGHPITILYGSNSGTCEALAHTLAADARGHGFLPTTVDTLDSAKQNLPADQPIVIITASYEGQPTDNAGHFYNWLQNVTELKTSYAVFGCGHSDWRQSFHRIPASIDSLLEKAGSTRICKMGSADAAKGDMISDFNGWEDETLWPALQKQYTCTDSETSSPSHGQSLSVEVFSKRASHLRSDVSEARVVSAKVLSAPGVAPKRHIELQLPSDMTYRAGDYLAVLPLNPAETVHRVLARFSLPWDAMLSITSKDHTTLPTEHPVSAQDLFSAYLELSQPATKRNVTMLIEVSHEEAIKEELKKLSDDFDAEITAKRVSLLDLVERFPTIALPLSAFISSLISMRVRQYSISSSPLSDQNRATLTYAVLDEPSTSGQGRHIGVASNYLSQLKPGDIVHVAVKPSHASFHLPSSPETTPIIMIAAGAGLAPFRGYIQERASQIQSGRTLAPAHLYFGCRYPDKDDLYRDEIDSWEQIGAVVAHRCFSQAPEQSGGHKHVDGLILQDKELLSELWEGGAKVYVCGSRGLGDSVKKAFIKLAKEKAVADGNKNAEDDAKLEKWFESLRNERFATDVFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNN4</accession>
    <name>N1QNN4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Elongation factor 1-alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">ERF-3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">ERF2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Eukaryotic peptide chain release factor GTP-binding subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Polypeptide release factor 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Translation release factor 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SEPMUDRAFT_146471</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765555.1">
        <property type="nucleotide sequence ID" value="XM_016903671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNN4"/>
    <dbReference type="STRING" id="692275.N1QNN4"/>
    <dbReference type="GeneID" id="27900808"/>
    <dbReference type="eggNOG" id="KOG0459">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007265_3_8_1"/>
    <dbReference type="OMA" id="ARFDECT"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018444">
        <property type="term" value="C:translation release factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002184">
        <property type="term" value="P:cytoplasmic translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03704">
        <property type="entry name" value="eRF3_C_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04089">
        <property type="entry name" value="eRF3_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000017">
        <property type="entry name" value="Eukaryotic peptide chain release factor GTP-binding subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000503">
        <property type="entry name" value="Peptide chain release factor subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000061">
        <property type="entry name" value="Translation release factor eRF3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003285">
        <property type="entry name" value="Sup35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01343">
        <property type="entry name" value="YEASTERF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Tr-type G" evidence="16">
        <location>
            <begin position="282"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="102"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="189"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="210"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMF17434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="723" mass="78085" checksum="F1CFA9A4B7E5F05D" modified="2013-06-26" version="1">MADQQPADSWEDSMQDDDLANQTQSQLNVNQGPPARGPTAFVPGASSFTPGAQSFQPGQQFQQYGYGQNYGGGYPQYGQQGYGQGQFQQYGYGAQQGYQQYGQQGYQQYQQPQSQQQAYVPPQQRQAPMIAKRGEALPAAGQPAAAAKPAAATSSTGAAPVKTLSLSAADTGAAAPKVEKAAGGAKVLSLGVPAPTPAAEKPAPKDASGKAAPEAGNKVAAAKAVEKAGESTPASGNTSPNASGRSSPSRAETKAEARRVELAAEEQAKEVDEADLREMYGKEHVNVIFLGHVDAGKSTLGGSILYATGMVDERTMDKYKRDAKEMGRESWYLSWALDQTKEERSQGKTVEVGRGFFETEKRRYSILDAPGHKTFVPNMVSGASQADVGVLVISARKGEYETGFERGGQTREHAVLAKTQGINKLCIAVNKMDDVTVQWSEERFKECITKLTTFLKGLGYNPKTDLTFLPVSAQTTVGIKDRVPKDVAPWNDQPSLLEFLDNMQSLERKLTAPFMMPIAAKYRDLGTMIEGKIEAGILKKENKYLMMPNRAEIQISALYGETEDEIPHATSGDQVRLRIKGVEEEDISPGFVLCSPKRPVHCVNQFEAQIRLLELKSIISAGFNCVLHVHSATEEVTFAALLHKLEPKTNRKSKKAPGFAKQGMNIIARMQVTGGAGSVCVERFEDYPQLGRFTLRDQGNTIAIGKITKLITDAQEAAEGAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNN8</accession>
    <name>N1QNN8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">MICOS complex subunit MIC60</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Mitofilin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SEPMUDRAFT_146476</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a role in keeping cristae membranes connected to the inner boundary membrane. Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 13">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion inner membrane</location>
            <topology evidence="1 13">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the MICOS complex subunit Mic60 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765565.1">
        <property type="nucleotide sequence ID" value="XM_016903675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNN8"/>
    <dbReference type="STRING" id="692275.N1QNN8"/>
    <dbReference type="GeneID" id="27900812"/>
    <dbReference type="eggNOG" id="KOG1854">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008024_1_2_1"/>
    <dbReference type="OMA" id="RLDHQMQ"/>
    <dbReference type="OrthoDB" id="10261039at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019133">
        <property type="entry name" value="MIC60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15415:SF7">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15415">
        <property type="entry name" value="MITOFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09731">
        <property type="entry name" value="Mitofilin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="45"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="187"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="333"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="91"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMF17444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="665" mass="72144" checksum="36A9762394821EA9" modified="2013-06-26" version="1">MLRIAVARSGKCLEHGIRAGGARQWQSQRLQPLARAYAVPAPPTTDKVVLPGSDSSTTAGVPKPPVLPSATTTSSSSITPEQSPLTPPTPTQVQSNPPAPSTTVGNLPPTGTGTAKTGPSSAPPPPPKKKGRFRRFLFTLIILSALGYGGGIYYSLINDNFHDFFTEYVPYGEDAVSYFEEREFRKRFPSSSSSSSNSWPQTRGENKVTIGRQSGISPRVAKAENDGGDVGLRGRHTSALAENDPKPAPKMQSVKEPTKPLTTEASPKSPAKQVGQSSESVTAQPAPTPVPTIDHLSAPEAHEPAVQEAIKLVNGIITAINNTPDSSKFGSVLAQAKSNLDKVIEEIKLAKAKAAHDAETEIKNAHLEFDQAAKELVRRLEGEMRDQETRWREEYEQEREKLSSSYQHKLSAELDTARKVYEQKKQNELIEQEISLQKKFMESVRSKVEEERGGRLSKLDELSGSVAQLEKLSSQWNEVVDATLQTQHLQVALEAVRAKLQASDTPTPFIDELVALKEVSKDNDVVSAAIASIHPAAYQRGIPSPAHLIDRFRRVASEVRKASLLPEDAGVASHAASAVLSKFMFQKKADRGLPEGDDVEATLARAEVLLEEGDLDAAAREVNGLKGWAGVLSRDWVGECRRVLEVRQAVDVISAESRLQSLLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNS5</accession>
    <name>N1QNS5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_146526</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765655.1">
        <property type="nucleotide sequence ID" value="XM_016903708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNS5"/>
    <dbReference type="STRING" id="692275.N1QNS5"/>
    <dbReference type="GeneID" id="27900845"/>
    <dbReference type="eggNOG" id="KOG1769">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148322_0_1_1"/>
    <dbReference type="OMA" id="MKIYCAR"/>
    <dbReference type="OrthoDB" id="442921at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16116">
        <property type="entry name" value="Ubl_Smt3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000155">
        <property type="entry name" value="Ubiquitin-like protein SMT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022617">
        <property type="entry name" value="Rad60/SUMO-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10562">
        <property type="entry name" value="SMALL UBIQUITIN-RELATED MODIFIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11976">
        <property type="entry name" value="Rad60-SLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="21"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF17534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="98" mass="10902" checksum="100919BBFE82B194" modified="2013-06-26" version="1">MTENNGTPPADQPDAQQPPSEHLNIKVTDGSNEVFFKIKRSTQLKKLMDAFCDRQGKTPQSVRFLFDGQRVNATDTPEILDMIDGDALEVHQEQIGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNW2</accession>
    <name>N1QNW2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_138381</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765835.1">
        <property type="nucleotide sequence ID" value="XM_016902876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNW2"/>
    <dbReference type="STRING" id="692275.N1QNW2"/>
    <dbReference type="GeneID" id="27900013"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_19_3_1"/>
    <dbReference type="OMA" id="LYGDPQT"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF147">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G01950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="5"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF17714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="441" mass="48444" checksum="E45133C5CC90BD61" modified="2013-06-26" version="1">MGRDLHVGIVGAGIGGVLASIAMARVGCKVTVLEAAEQLGEIGAGIQMTPNVARLLIRYGVDKVIGDDLVRITELNLRKKDGTKVGYTAVKRVEDALGYPWWLVHRHHLHNGLVEVARQSGVNLIISSRVASISQCSDGRVEVATQKGVRHTFDLVVGSDGVQSVVRRSLFPNVKPRPPTGNCAYRAIVPYEEVRNDPITRELVEDANGNPMNTMEVWMASTGYIISYPISGGKDFNMVLSHFRSPPVDAVQEVSIDEVRQEYKDYDPRIKRVVEMIQPPISRWPLLVTGPLDSWSNAEKNVVLVGDSAHSMVNHMAQGAATSMEDGAFLARSLAHVVSGSISLQDAIALYEKGRMPKARYKQQVSYLNGWIWHLPDGPAAEARNDTMKCELEGQVPIRSANLYGDPTTVLECYGYDAESHADQIDRNVVKGRDGKDSDMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M3ARI1</accession>
    <name>M3ARI1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_152379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF08094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756215.1">
        <property type="nucleotide sequence ID" value="XM_016907412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3ARI1"/>
    <dbReference type="GeneID" id="27904549"/>
    <dbReference type="HOGENOM" id="CLU_1679046_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF08094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="157" mass="17341" checksum="F6FE390B68B52CFF" modified="2013-05-01" version="1">MQDHVGSRHIRQLDVLYKPMLVAGLSCGSMLVVGCSVTNPVQFRPPQLQYHSARTLARFQDSQYRCALSDGTVAALFRRCVAAIPVVVLPNQFGSAAISRSPLREASRDVGLQQNRGQAISSWWYRLQHIVSSSIAVISWHFIISGRRHISSAVPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M3ASS6</accession>
    <name>M3ASS6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zinc knuckle-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_152187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756680.1">
        <property type="nucleotide sequence ID" value="XM_016907289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3ASS6"/>
    <dbReference type="GeneID" id="27904426"/>
    <dbReference type="eggNOG" id="KOG3116">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062858_0_0_1"/>
    <dbReference type="OMA" id="HYSYECT"/>
    <dbReference type="OrthoDB" id="437973at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13917">
        <property type="entry name" value="zf-CCHC_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF08559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="27880" checksum="BDC3659241DE0587" modified="2013-05-01" version="1">MNRYRFGGPSKATATTLCQKCLKRGHYTYECTSAQQDRPYTSRPSRSQQLSNPKLAPKLSAVLPPVEPASKNSPSRAPVDRDHPVNGKTSRPTSRRRRSNSTHSLDSVSSFSTNRSRSSSRTPPPASRAPGARRNRSLSRSPTRSPVRRTISPPVASTRLGRRRSASPDQYRPSARSKSPERVPKEAYTEARYRRRSRSRSPYRGDKRRSSGSASEGRDTAPVNRSRPAARERSLSPYSQRLAMTKAMNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M3ATF0</accession>
    <name>M3ATF0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HCP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_151725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756915.1">
        <property type="nucleotide sequence ID" value="XM_016907002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3ATF0"/>
    <dbReference type="STRING" id="692275.M3ATF0"/>
    <dbReference type="GeneID" id="27904139"/>
    <dbReference type="eggNOG" id="KOG1550">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008036_1_0_1"/>
    <dbReference type="OMA" id="NRIRSTH"/>
    <dbReference type="OrthoDB" id="4095816at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051726">
        <property type="entry name" value="Chitin_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430:SF2">
        <property type="entry name" value="CHITIN SYNTHASE REGULATORY FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430">
        <property type="entry name" value="PROTEIN SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="483"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="564"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="584"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="627"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="685"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="730"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF08794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="786" mass="85318" checksum="15ABA29F9220ED17" modified="2013-05-01" version="1">MANGASDHNQMGATFVPGGNDDFYMPPASPPLVQPEPQRVNPEMQNQISVGLHNLELGPHLSPFPKLVNPGPNVPPSDEELETRLENARMPVLNSNDPEMQLAWAADVLMYAVVCEEEADRVASMKPHIARPATPRIEHQLKTDAMNIVTFLADQYHPRAEFLRGMWLERGHFGQRQDKREAFHSYNRAADKHFARADYRIGMMHESYNDPVKALRHYHKGVAAGDAASCYRVGMMTLRGQHGQQQDYTKGISLIRQSAECADENAPQGAYVYGMLLARQLPQIDLPDSYLPFDEAAAKFYIEKAASLKFAKAQAKMGSAYELGSLGCEFNPALSMHYNALASKQGEPDADMALSKWFLVGSEGLFAKNEELAYTYAERAAATGLPTAEFALGYFNEIGMYVPVNLEKALEWYEKAAKHGNQDAGGRIEGLKRKEVLNRQDHEKVALNRIRSTHGSMRGQQPESLRSKQDSGLGAVTETYQPYSNGARAVQSPGTSTTPYPAHDGPPRTETRSKSVAPYPMADGPPQIGGGMFSTSQPSLLANVNAALYDRPSSAFQINPEILQGSAPGTKAYPGGPRPYPSGNMASAQSRSHTAQPQALDQRQSSAPAGSMNGQPMHPNDPRGRPTVNTRIASGPPNLQSHPMSPTPAPGQLQHPQTAPQPSQPPVGLGYQAPYTERPQTVDPTWRDKSEPRRGRNARPAQESRYRPAAGNGKLPTAGGTPLGRGGGKTSTPPQNQSPARPGSDSTTPKPAAEGLSAPKPPKKGPQTFDEMGVPAHNQDKDCVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M3AXS0</accession>
    <name>M3AXS0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Acid protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_150439</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759656.1">
        <property type="nucleotide sequence ID" value="XM_016906177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AXS0"/>
    <dbReference type="STRING" id="692275.M3AXS0"/>
    <dbReference type="GeneID" id="27903314"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013253_9_3_1"/>
    <dbReference type="OMA" id="KRWAILP"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05474">
        <property type="entry name" value="SAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033876">
        <property type="entry name" value="SAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF65">
        <property type="entry name" value="ASPARTIC-TYPE ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8 11" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004031613" evidence="9">
        <location>
            <begin position="19"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="10">
        <location>
            <begin position="72"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="309"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="341"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF11535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="549" mass="57361" checksum="AAE7C99A0CBFB4B8" modified="2013-05-01" version="1">MRSLVLSPVLLATAVVHALPELSIVKRDRQTNGRTDLFARSIPAPPQLLRRQDGTVGSNIFDVLSWSSGGAYYTNVTVGTPPQLQTVILDTGSSDLYFDASSATTCENPPSATQACEGGTFDLTQSNTYQEVHPAPSFNTSFGDGSSASGPYGSDVIGIGDVQISPVQFGVATTVQSTTGYAIGLMGLGYSSNEAVTSARYFYQNMPEVLKDSGEINSRLYSLFLNDAGAESGTILFGGIDRSKYTGTLATVNFLSQYYEGENAGLNFITTVTAASVMSDGQETELWSGGSDGIDAYNRNDVALPVLLDSGSTAWQVPSNYYNRYIAPQFPFVDRSGACSCEYASSGPSLQLEFAGKVTINVTADQFIIPVIDPQTREPIPYDRKGNNACVFLIQPDTTGAPFLVLGDAILRSMYVVYDLDNGQGSIAQANQNPGDPDVVTVEAGPTGVAAAVSGVKTAPANTNTPPPEVTRTVSFTVATAETAIATATGNAAIPEDAQISASLSSAVAPSATSSQGAANVLVPCVDFSSIWVASIWTAGIALGVGVMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M3AZ06</accession>
    <name>M3AZ06_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_149334</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760898.1">
        <property type="nucleotide sequence ID" value="XM_016905496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AZ06"/>
    <dbReference type="STRING" id="692275.M3AZ06"/>
    <dbReference type="GeneID" id="27902633"/>
    <dbReference type="eggNOG" id="ENOG502TIPC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_727944_0_0_1"/>
    <dbReference type="OrthoDB" id="3650883at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF1">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF12777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="380" mass="42225" checksum="170F4B1DB898DA05" modified="2013-05-01" version="1">MLCSQPIPCQTCSSCAASAARSAPRAIAIAPRNYNNQWFTRSRQQRIKAYQTETRLQVPAMHAMSDEAALATFNELRRLQRTKKVTARPMPTRCQELRKPNSTPFRLLDLPAEMRVRIWEDALQEPFVLRLRSFATPALARTSRQLRQECLPIWFATNTFVAEVKSTLLGISVCASHGPKAEYIAERDTRFHRLGSLDLSPIVNSLLATCPPRAIRLKNIDFCMLGAGSHQVWQTSGRYAVLSVRDGRPVRVTTHVGGGTSPEFTKHVLHVFKQGKAFLEHLVADSEFEGLYMLQIKEVAAAFRTEPLPLPVPAPAPVLPPTLPTLGSLAPVAPSTKSQARNLARGADESRMSGQLSAKARVMDDVHDEFDLPQAETYFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M3AZV0</accession>
    <name>M3AZV0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Clathrin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_148432</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasmic vesicle membrane</location>
            <topology evidence="1 6">Peripheral membrane protein</topology>
            <orientation evidence="1 6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Coated pit</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="6">Cytoplasmic face of coated pits and vesicles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the clathrin light chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761173.1">
        <property type="nucleotide sequence ID" value="XM_016904926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AZV0"/>
    <dbReference type="STRING" id="692275.M3AZV0"/>
    <dbReference type="GeneID" id="27902063"/>
    <dbReference type="eggNOG" id="KOG4031">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069856_0_0_1"/>
    <dbReference type="OMA" id="FYENYNT"/>
    <dbReference type="OrthoDB" id="5512at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032050">
        <property type="term" value="F:clathrin heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000996">
        <property type="entry name" value="Clathrin_L-chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10639">
        <property type="entry name" value="CLATHRIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10639:SF7">
        <property type="entry name" value="CLATHRIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01086">
        <property type="entry name" value="Clathrin_lg_ch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0168">Coated pit</keyword>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF13052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="249" mass="26740" checksum="F4E1D922051CBBCB" modified="2013-05-01" version="1">MADRFPSLEEFDEGKTEATGPSALDAIDEPSDFLARERAALGDDAEQFTSSADNTATVADGDDDDDLLGGGGNTNGSSAVHNDDMMGDFESSFPAVSMSQNEQVAPGGTITGSAAPFQAPRPEEYESEPDVVREWRERRDLQIQHRDEVSAGKKAETVKAAQEAIDDFYEQYNNRKDKQIAQTRKEAEEFLKSREDTTAGGTSWERIAKLVDLSGKGSAGGAAGSGKAKMRELLISLRKDEKAPGAIGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M3AZW2</accession>
    <name>M3AZW2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_116130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761188.1">
        <property type="nucleotide sequence ID" value="XM_016901230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AZW2"/>
    <dbReference type="GeneID" id="27898367"/>
    <dbReference type="HOGENOM" id="CLU_1908006_0_0_1"/>
    <dbReference type="OrthoDB" id="4760831at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF13067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="133" mass="14784" checksum="399B969557AAA8B5" modified="2013-05-01" version="1">MPEEMNNHLSPTMMDVKDDSSDWQTSDEDRRGKPKTRSQEPPGPAWPMPPVQDWANVNKQVWIIIEGSLTREGPFTVKGRRADNNTKKWKYDLVDAQGNKRMGVLESQLKRSGTDEESDNGGVGSSAPTLSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M3B0I7</accession>
    <name>M3B0I7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_148649</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761423.1">
        <property type="nucleotide sequence ID" value="XM_016905056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B0I7"/>
    <dbReference type="GeneID" id="27902193"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012970_2_1_1"/>
    <dbReference type="OMA" id="VMLNTAW"/>
    <dbReference type="OrthoDB" id="2241241at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015343">
        <property type="term" value="F:siderophore-iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000197">
        <property type="entry name" value="Siderophore iron transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF92">
        <property type="entry name" value="GLUTATHIONE EXCHANGER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="219"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="265"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="350"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="448"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="478"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="561"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF13302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="635" mass="69161" checksum="1E6F073DEC657E86" modified="2013-05-01" version="1">MDRDLKRAEAGEASSGDEAAPPYALQDIKLIGKTSPGVQRMEAISKHITFKDRILLFITIFVLAYAYTLDNTLRYTFQTYATASYGQHSLLATVAVIRGVAAAAGQPTAAKIADVFGRVELLILSVVFYIAGTVLETFSNNVREFSAGAVLFQIGWTLMSLLIEIIIADTTSLRSRLFFSFIPNMPYLINSWISGNIAARIVDPLNDPTGAGAGGSIGWRWGIGMWAIIVPALTIPLVGALFMAHRRAKKHDDLSNFRTPYQMLGPLKLAVALFWQLDVISIILIVAALGCLLVPFTLTDTSFAGGQQSWVQVHILLPLILGVLLFPVFLWWQTKSPHPMVPFKLVKDRAVWGPLCLALFINFSWYLQGDYLYAISTIAFGQSVLSAQRIGTLFNFCSTITGIICGLVVLKVRRLKPFIFIGSILYLISFGLLIRFRSNESGGVSGLIGAQVLLGIGGGLFPYPALASIQSATQHEHVASVTALYLALYNVGGSFGGAVSGAIWTNTLQDAMFNALSEISNNATEITAAMYANPYVTVVEYPIGTPERSAIIDGYRHSQKLLTITGLCLCLPIILFGLCTRNPRLPDTQSIATAEMQDENLVADDRGNITRVESVDAGNRGSRSWGRKVVDFLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M3B2I2</accession>
    <name>M3B2I2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glycosyltransferase family 2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_41688</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF13967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762088.1">
        <property type="nucleotide sequence ID" value="XM_016908840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B2I2"/>
    <dbReference type="STRING" id="692275.M3B2I2"/>
    <dbReference type="GeneID" id="27905977"/>
    <dbReference type="eggNOG" id="KOG2571">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019940_4_1_1"/>
    <dbReference type="OMA" id="HEKHIWY"/>
    <dbReference type="OrthoDB" id="3828420at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06434">
        <property type="entry name" value="GT2_HAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052427">
        <property type="entry name" value="Glycosyltrans_GT2/GT47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47844:SF1">
        <property type="entry name" value="EXOSTOSIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47844">
        <property type="entry name" value="SYNTHASE CPS1, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G02500)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13641">
        <property type="entry name" value="Glyco_tranf_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="465"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="468"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="478"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF13967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="493" mass="57488" checksum="0AD24886185A49F3" modified="2013-05-01" version="1">MVSWYYVAVFAWYVLFRYIRLIVNCISHWTFKPVPIAENPSYTSQDVTIILPTIATGGDSLRDTISTCLKSEPYELLLVTIDANSEALTKMANEINAKKIRVLSIREANKRRQMCRGIPEVVTRITIFVDDDVVWPEKVLPWMLAPFEDPKTGGVGTSQRLKRPDSMSAFAFLGATYLERRNWDCSACLNIDGGLPCLSGRTVAYRSDILQDEAFTHGFTHEEWRTMQLNADDDNFITRWLYSHDWKIKMQYHKECEVRTTLEDGPKYLSQCLRWVRSNWRSNLTSLFVERHYWYTQPWSTYTVLQTTLTAWALPYDILIFTSWYQASTEWSSDSRWYLFTFLILWTYGFSKTVKLWGHFFRYPADVVYMPLYIAFGYFHGLIKLYGAFTLSETTWGSRDGADTDNRVRMIKLPAYGSSQLDQPDGRKSESFDYPPSGMPPVVDQLPAYATHMEHEPIPLLSTTNVQQHHHHHHHHNNMININNNNNTNHYHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M3B6M0</accession>
    <name>M3B6M0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peroxisomal membrane protein PEX16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_147314</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peroxin-16 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763548.1">
        <property type="nucleotide sequence ID" value="XM_016904222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B6M0"/>
    <dbReference type="STRING" id="692275.M3B6M0"/>
    <dbReference type="GeneID" id="27901359"/>
    <dbReference type="eggNOG" id="KOG4546">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036533_1_0_1"/>
    <dbReference type="OMA" id="PTWQSTY"/>
    <dbReference type="OrthoDB" id="2021143at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013919">
        <property type="entry name" value="Pex16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13299">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13299:SF0">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08610">
        <property type="entry name" value="Pex16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="2" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="183"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU365003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF15427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="390" mass="44310" checksum="52BBEFFF28151CE4" modified="2013-05-01" version="1">MTGAMQGLKHAAEQTKVVVKLPTKWIHMYGDFITKNAGAVGQVEGALRSLTYLAPGGMRMSDVGTEGLNSSLQLLSLYHDNLLSRALAHTLRTQPRHQSPHNRYTRFYCQKSPTYRRMATTLTVVQYTELLLEMMAKRKGEKAKWRLVIFLEAVKAVCRLIMMRLTNSRPLLTPPLPEREVVEEKAAPEEEELSTPPSEPSEPGSEQWTMPRTSLTLPPLPDANDISSYLLSKVLTADDIKPPKQLVHRTSGFGEIAEVMFILRPVIYATAMAYWCQREDGRGKADWRPWLLGLSIEYGARSLAKRDLDSRRPGGVARGLTQLEREEIKKRGWSLAWWTMRGAFYENITRTMIQGAANKLKGKPILDMVGTFIEDYEFLWDEYYFPTATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M3B744</accession>
    <name>M3B744_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cercosporin MFS transporter CTB4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cercosporin toxin biosynthesis cluster protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_147485</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">MFS transporter; part of the gene cluster that mediates the biosynthesis of cercosporin, a light-activated, non-host-selective toxin. The perylenequinone chromophore of cercosporin absorbs light energy to attain an electronically-activated triplet state and produces active oxygen species such as the hydroxyl radical, superoxide, hydrogen peroxide or singlet oxygen upon reaction with oxygen molecules. These reactive oxygen species cause damage to various cellular components including lipids, proteins and nucleic acids. Responsible for secretion and accumulation of cercosporin, but does not play any roles in self-protection against the toxicity of cercosporin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the major facilitator superfamily. CAR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763783.1">
        <property type="nucleotide sequence ID" value="XM_016904328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B744"/>
    <dbReference type="STRING" id="692275.M3B744"/>
    <dbReference type="GeneID" id="27901465"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_11_4_1"/>
    <dbReference type="OMA" id="GWNQVVG"/>
    <dbReference type="OrthoDB" id="9986881at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF59">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G10370)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="232"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="391"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="475"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="500"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="568"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="166"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="608"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="627"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00053977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00069139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00077167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF15662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="637" mass="70070" checksum="EB3A7B654E91058E" modified="2013-05-01" version="1">MDFRSEQERARRPDETERHYEPAEEDVNRERVVETAVPTNSSSALRLQESHEKHHVHDDDDNDVDDDSSDTSSVFSEGRHTEGPPSLRRNSVGSPGILSRTTSRNVERVQTTASTVLSTIRSRVPRAPFTHPLTHQKTSTDVLVDFDGPDDPYRPANWPFRKKAVTTVLYGFTAMGATFASSVYSSAVNEISEEFHIGSTVSTLGVSLFLVGFGIGPLFWAPLSEVYGRKRTVLVPYFISAMFAFGGGAAEDVQALMICRFWQGIFGSAPVTNTGGVLGDIWSAEQRGAAMVGYAMAVVGGPTIGPIIGGAFIVSGVGWRWTQYFTGILMMLFLVLDVLILDESYAPQLLVIKARKLRHESGNWALHAKHEEWDISLAELGNKYLIRPFQLLATPICALMALYASFCYGILYASLAAFPIEFQETRGWNDLVGSLPFLAMLIGICIGAGGNYLNQQFYIQRLKANHYRPVPEARLPPMMAGSILFAAGLFTFAWSSAPHIHWIVPCIGIALEGIGFFTIFQAALNYLIDTFQRYAASAVAANTALRSGLAAAFPLFISPMLHHMGIDWGVSVFGFCAVAMIPIPFAFYRFGRRVRARGAWSRESVYPIGEDEGEKGGGNSEDEGGKKMKKKKTKLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M3B7U7</accession>
    <name>M3B7U7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL22</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L17</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_147645</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764023.1">
        <property type="nucleotide sequence ID" value="XM_016904436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B7U7"/>
    <dbReference type="STRING" id="692275.M3B7U7"/>
    <dbReference type="GeneID" id="27901573"/>
    <dbReference type="eggNOG" id="KOG3353">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083987_0_0_1"/>
    <dbReference type="OMA" id="NTYETAR"/>
    <dbReference type="OrthoDB" id="10254664at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.470.10:FF:000010">
        <property type="entry name" value="60S ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="entry name" value="Ribosomal protein L22/L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_uL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018260">
        <property type="entry name" value="Ribosomal_uL22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005721">
        <property type="entry name" value="Ribosomal_uL22_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_uL22_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01038">
        <property type="entry name" value="uL22_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593:SF10">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="Ribosomal protein L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00464">
        <property type="entry name" value="RIBOSOMAL_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2 6 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF15902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="186" mass="20759" checksum="3AFBAD815943B6D1" modified="2013-05-01" version="1">MVRYAATEIESAKSARARGSYLRVSFKNTRETAQAINGWKLQRALTYLDNVQNKAEAVPMRRYAGSTGRTAQGKAFGVSKARWPVKSAEFLSSLLKNAEANADTKGLDTSNLIVKHIQVNQAPKQRRRTYRAHGRINPYMSNPCHIELILTEGEEVVHKAPETVARTAHLNSRQRATRQKKAITAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M3B818</accession>
    <name>M3B818_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_147690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764098.1">
        <property type="nucleotide sequence ID" value="XM_016904465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B818"/>
    <dbReference type="STRING" id="692275.M3B818"/>
    <dbReference type="GeneID" id="27901602"/>
    <dbReference type="eggNOG" id="KOG2508">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016785_6_1_1"/>
    <dbReference type="OMA" id="YWHDMEF"/>
    <dbReference type="OrthoDB" id="415358at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF99">
        <property type="entry name" value="BIFUNCTIONAL PEPTIDASE AND (3S)-LYSYL HYDROXYLASE JMJD7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="1">
        <location>
            <begin position="107"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF15977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="310" mass="35559" checksum="B4DC1EE6FF5A8F8F" modified="2013-05-01" version="1">MMHYVAKNRPFVVRKGAGHWRAVHAWNSAYLRQVMIGRHVRVAITPTGNADGVVEDERGGHLMLVEPYEKSETFDDFLDHVQADAGFSEQERKNRNVRYCQTQNDNLRDEYAALFHDVPNDINFASTALNLEPDAVNFWLGNERSVTALHRDNYENIYVQIRGQKHFTLLSPVEMPCVNETPIRFARYQPVSDEDALQVELKPRLDPAGEPIPTPIWDPDEPKARATAYSRFAKPLHVTLEEGDMMYLPAMWYHKVAQSTGGEDFSCAVNYWYDMDFSGTFWIQNGFLRDMVQAAAKQVQYPELRLGDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M3B843</accession>
    <name>M3B843_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribonuclease III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_106183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF16007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016900619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B843"/>
    <dbReference type="STRING" id="692275.M3B843"/>
    <dbReference type="GeneID" id="27897756"/>
    <dbReference type="eggNOG" id="ENOG502SSJ0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000907_3_2_1"/>
    <dbReference type="OMA" id="HHTMANK"/>
    <dbReference type="OrthoDB" id="67027at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase III" evidence="1">
        <location>
            <begin position="14"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF16007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="151" mass="15753" checksum="E1232D04898AE40C" modified="2013-05-01" version="1">MATAAQIQLAKVFITNRFGYSIQDLGLVAEAMDTTGFYRAGSNKRLAIVGDAALKIAIAAAWYPTGAPRGEYSVYSSHVSNINLATVARLIELGQHLILNPGHFGAVSSNTLATGLEAFFGAIYQDCGGDISIVSAAMTAVGIKLPGTDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>M3BPI8</accession>
    <name>M3BPI8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_152372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF08083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016907406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BPI8"/>
    <dbReference type="GeneID" id="27904543"/>
    <dbReference type="HOGENOM" id="CLU_2905616_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF08083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="62" mass="7020" checksum="756F163818BD6FB6" modified="2013-05-01" version="1">MSTHQRGSSTQKVFRSNGIEREEHQLPANRMNYMTNTWSEYPSKGNDSEPSEASIAAPCFIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M3BRT3</accession>
    <name>M3BRT3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-14 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_151743</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756944.1">
        <property type="nucleotide sequence ID" value="XM_016907014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BRT3"/>
    <dbReference type="STRING" id="692275.M3BRT3"/>
    <dbReference type="GeneID" id="27904151"/>
    <dbReference type="eggNOG" id="KOG4159">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017137_2_1_1"/>
    <dbReference type="OMA" id="CIRCLIV"/>
    <dbReference type="OrthoDB" id="5588846at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327">
        <property type="entry name" value="RING FINGER PROTEIN 127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327:SF51">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR OF YEAST FORM ADHERENCE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SPX" evidence="3">
        <location>
            <begin position="1"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="2">
        <location>
            <begin position="387"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF08823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="483" mass="55524" checksum="603CD8A081EA92CB" modified="2013-05-01" version="1">MKFGREYETALANDGFPQEWVARAIEYKNLKKAIKKVHRELESLGLDHQTLVNLNELVLHGTTPKPETTASRDYFAGTRPSLSSIPEEFSPQLRILVDGKTGAPLDAKLAPETWESLRKLARYEMVVNRRQEHMGDHAHTHAVAEHVTSPPVQQDQARPCSPARVADARWVQVPLASAKDFFQMLEPKLMELDCLRDAETHNLEEEILDLGEAVENVIQPVREGYEAKRGMSYRDLYFWREMFRLYLETPIFYSETERRRGALTYAEARTNLENYDQQLRDTKLLDKMRTPQAKEAARRFLDLNLHILSIMHFQEMNSKAMTKIMKKFNKRTHIEGNEFVSSLAVKYPAIAAKSSAGGFADSIARDMHAEIGSKVLAIVPQLDDWICPVCYGMAWRPVNLGCCRSVFCIRCIIHLQDQDMKKCPMCNSESVLKANGANIHFETMEFLEKYFPMEVKKRQKENERALLVRDYGEDFVKPSCSLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M3BSB9</accession>
    <name>M3BSB9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">rRNA adenine N(6)-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_120879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757109.1">
        <property type="nucleotide sequence ID" value="XM_016901644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BSB9"/>
    <dbReference type="GeneID" id="27898781"/>
    <dbReference type="eggNOG" id="ENOG502QY7G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014537_1_0_1"/>
    <dbReference type="OMA" id="VDILDLW"/>
    <dbReference type="OrthoDB" id="16079at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.100">
        <property type="entry name" value="Ribosomal RNA adenine dimethylase-like, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023165">
        <property type="entry name" value="rRNA_Ade_diMease-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="606"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF08988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="626" mass="70561" checksum="6E943BF30C3B131A" modified="2013-05-01" version="1">MKDGSVRPPEVVGERLMDDILEYLAPTLERYKGCAIFDLCPGTCLWSRKVHDFLKPTTHLLVEPDAQFHEHVHELVSQPGSSYKHIAPPRGVLPYCFDQFHHVFDEGGPIPRPRLASNDPGLLETDYSLLVIGSLNRRDTFHMNGGKTRSGSLWATDMMCWSALENKHMHRRGPVRMLLWAPEQDRLVYLPEWIIKRTEKEATISLAMNVQAVAEVGSVKKKRANSYEWNSPARWSGFDLASEERVSRRMSQINMRVPEGRSIRHMSRTDVDRQMPKGKSPYEVCYESVEEVESALADLVQHWNEHKSRYTGVGASGLAKGVSRRDATLEELYSLVTFSDLVDAMHENPCKLSRSAIRKEEALKEEMDDEAEAPKGAVPVKSAQKTHMRGIDARITLRADAALRAFNLEVHCKILEEQGHDISSLTQRITQFHDELIETTSYGLEDWERLVEDWMSFYAPTPLLAIDKRQYEPLKANPEDFWPAQNLDLLDFTPTNCDLTVPGLANQIKAAGACRDLLNYLFLFRKQSITLALEKLAPNAASDLICQVPAMTDPRRGGRLDPKFLKVRQLTSEMLQGLTKAWFEWPFKPEGWEFLGIARGGDYSGGGGSDDDNAAAAVPGVVDDSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M3BTW0</accession>
    <name>M3BTW0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">LSM complex subunit LSM5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LSM5</name>
        <name evidence="12" type="ORF">SEPMUDRAFT_151138</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758211.1">
        <property type="nucleotide sequence ID" value="XM_016906623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BTW0"/>
    <dbReference type="STRING" id="692275.M3BTW0"/>
    <dbReference type="GeneID" id="27903760"/>
    <dbReference type="eggNOG" id="KOG1775">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076902_6_0_1"/>
    <dbReference type="OMA" id="NNICTLI"/>
    <dbReference type="OrthoDB" id="429711at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01732">
        <property type="entry name" value="LSm5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000003">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033871">
        <property type="entry name" value="LSm5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20971">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20971:SF0">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="6"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF10090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="81" mass="8977" checksum="3E172311BFEAB5A3" modified="2013-05-01" version="1">MSSQLLPLELIDRCVGSPIWVIMKGDKEFSGTLMGFDDFVNMVLEDVTEYDYTGAHTKLKKILLNGNNVAMLIPGGMPDQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M3BU44</accession>
    <name>M3BU44_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">6,7-dimethyl-8-ribityllumazine synthase</fullName>
            <shortName evidence="7">DMRL synthase</shortName>
            <ecNumber evidence="3 7">2.5.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_51052</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:26152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="2.5.1.78"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DMRL synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.78" evidence="3 7"/>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758316.1">
        <property type="nucleotide sequence ID" value="XM_016909183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BU44"/>
    <dbReference type="STRING" id="692275.M3BU44"/>
    <dbReference type="GeneID" id="27906320"/>
    <dbReference type="eggNOG" id="KOG3243">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089358_2_0_1"/>
    <dbReference type="OMA" id="CQGVTQG"/>
    <dbReference type="OrthoDB" id="2965at2759"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009349">
        <property type="term" value="C:riboflavin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000906">
        <property type="term" value="F:6,7-dimethyl-8-ribityllumazine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09209">
        <property type="entry name" value="Lumazine_synthase-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.960:FF:000005">
        <property type="entry name" value="6,7-dimethyl-8-ribityllumazine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.960">
        <property type="entry name" value="Lumazine/riboflavin synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00178">
        <property type="entry name" value="Lumazine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034964">
        <property type="entry name" value="LS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002180">
        <property type="entry name" value="LS/RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036467">
        <property type="entry name" value="LS/RS_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00114">
        <property type="entry name" value="lumazine-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058:SF0">
        <property type="entry name" value="6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058">
        <property type="entry name" value="6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE DMRL SYNTHASE LUMAZINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00885">
        <property type="entry name" value="DMRL_synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52121">
        <property type="entry name" value="Lumazine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF10195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="207" mass="21948" checksum="6F25E2E3749DBF4C" modified="2013-05-01" version="1">MTTLKGPGEAQTYDGSNLRIGIVHARWNKKLIDALLQGTLKSLKAGGVKQENIVIQTVPGSYELPYAVQKMFQASQSQPTGLLASATDLLAGSTTDLTQTAKESSKSEGASKEPFDAIIAIGALIKGSTMHFEYISDAVSHGLMKVQLDLGVPVVFGLLTLLTEEQGLERAGIDAAGKGHNHGEDWGSAAVELGVKRRGWAEGKFVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>M3BWW2</accession>
    <name>M3BWW2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_125703</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760657.1">
        <property type="nucleotide sequence ID" value="XM_016902006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BWW2"/>
    <dbReference type="GeneID" id="27899143"/>
    <dbReference type="HOGENOM" id="CLU_2943295_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF12536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="60" mass="6637" checksum="B7BB7A57D1CA7B40" modified="2013-05-01" version="1">MRQFAKPNKTQILLSTARYNISFVLQTEKHSHGSSSYAAEGAFYPGEKGVESAYQSVPPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M3BYG8</accession>
    <name>M3BYG8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stress-response A/B barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_148489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761227.1">
        <property type="nucleotide sequence ID" value="XM_016904951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BYG8"/>
    <dbReference type="GeneID" id="27902088"/>
    <dbReference type="eggNOG" id="ENOG502RGKI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120569_1_1_1"/>
    <dbReference type="OMA" id="MTVFFKP"/>
    <dbReference type="OrthoDB" id="3830014at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013097">
        <property type="entry name" value="Dabb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07876">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00886">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51502">
        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stress-response A/B barrel" evidence="1">
        <location>
            <begin position="3"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF13106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="103" mass="11859" checksum="4914AD9D5F5C7328" modified="2013-05-01" version="1">MPIQRITYFKVIDDGHFATLFDAYRTLKKDNQKDGKPYILEISGYQPIPDARNQGYNFVSMSKFKDLEDMKFYDNECPAHGALKALNVGKVDPPVMTTYFEVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M3C131</accession>
    <name>M3C131_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GA4 desaturase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_115290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF13996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762117.1">
        <property type="nucleotide sequence ID" value="XM_016901146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C131"/>
    <dbReference type="STRING" id="692275.M3C131"/>
    <dbReference type="GeneID" id="27898283"/>
    <dbReference type="HOGENOM" id="CLU_042688_2_0_1"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF3">
        <property type="entry name" value="OXIDOREDUCTASE AN1597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF13996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="34341" checksum="D1EFA53064A5F70C" modified="2013-05-01" version="1">MSRQVANINLPKPPPSAEFLETPISLYTTSDTFRDEREVFVRDVRDELHRFTIEKEGLEFLHDPVDIQNWDDEDEVREVLLKKTPELILKRLGAKSIFLTAERIRRSVDNSTKSDTTPVFAIHGDATRQSGLELLRTSLEKMSPTERSKLNLPSSLTTTTTTNNTTNTGRVMLINVWRPLKTITRDPLGFLVPSSINASEERHEQLFSRPADTFKVFGKPLGDYWLDTASYGEQHEWVFLRHQKREEPVMFVQWDSEGVEEGKFENRMSVFHSCFEDEEYCGDEGRASMELKCLVFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M3C1B4</accession>
    <name>M3C1B4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L14b/L23e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_147921</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762212.1">
        <property type="nucleotide sequence ID" value="XM_016904600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C1B4"/>
    <dbReference type="STRING" id="692275.M3C1B4"/>
    <dbReference type="GeneID" id="27901737"/>
    <dbReference type="eggNOG" id="KOG0901">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095071_3_0_1"/>
    <dbReference type="OMA" id="IRQSKPW"/>
    <dbReference type="OrthoDB" id="407959at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00337">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.150.20:FF:000003">
        <property type="entry name" value="60S ribosomal protein L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_uL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_uL14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_uL14_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006344">
        <property type="entry name" value="PRK08571.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L14/L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761:SF8">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF14091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="140" mass="14860" checksum="C2C20379D2B6A22E" modified="2013-05-01" version="1">MSANKRGGTSGQKLKMTLGLPVGAVMNCCDNSGARNLYIISVKGFGARLNRLPAAGVGDMVMATVKKGKPELRKKVMPAVIVRQSKPWRRADGIYLYFEDNAGVIVNPKGEMKGSAITGPVGKEAAELWPRIASNAGVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M3C1S7</accession>
    <name>M3C1S7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tyrosine specific protein phosphatases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_148034</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762387.1">
        <property type="nucleotide sequence ID" value="XM_016904661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C1S7"/>
    <dbReference type="STRING" id="692275.M3C1S7"/>
    <dbReference type="GeneID" id="27901798"/>
    <dbReference type="eggNOG" id="KOG2386">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013931_1_1_1"/>
    <dbReference type="OMA" id="PGIRHGH"/>
    <dbReference type="OrthoDB" id="428974at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004484">
        <property type="term" value="F:mRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000090">
        <property type="entry name" value="Dual specificity phosphatase catalytic domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051029">
        <property type="entry name" value="mRNA_Capping_Enz/RNA_Phosphat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367:SF25">
        <property type="entry name" value="DUAL SPECIFICITY PHOSPHATASE CATALYTIC DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G03540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="2">
        <location>
            <begin position="554"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF14266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="642" mass="70854" checksum="099AD614DB81EF38" modified="2013-05-01" version="1">MATSVVNALHGPALLITGVAGAAAFTWLISRLPMFQRITDAASTDPGLLRARSKFERYETPSGHVYPRIRTFYNQHTNAEKLPADLPLIVLQHGLGGSVAQFAPLLNSLTQIAPCLAIDLPGCGLSDFRPDEIEAYTTTAFAELLYVAIDRYRNKETNQKVILIGHSMGCSITALLASSSSPLHHLCSDVIISLVAICPRSRTMSEHELRGIARLGYLPSVVFDLMRMYDRIGGQESASVLRVIGKGADTETKKLQLRFNQQSKSAVFQRYIAAAAMQETTATQDGEDSILGKRTWAAIKVPLMLVAAEDDKLAPVEEAVRIKKWLKPDRHDSVATDPASGVIEAAEPQRDDLEIPSLLAKASDVSVATEPTTQTETSHISHTPSHASAAEIQQEETTTVHGSYLKTTIFPSPTSHGLLYSNSDVRILSRRIETFLATYADARVAPGWQLRHMTTSGKWDVKNLKKWQAVAPCSEPIGGVFRAMKTMREIDEVHSPPEFAKKYGWKVIPDGVAAVVDISLDVPVYDKKGLEAAGIEYYKLPIVSKQPPSADEVEQFIALIDSLRESIKLKSSSGDEIHPTIGVHCHYGFNRTGANIVCYLVERLNWKLQDALDEFAQKRPPGIKHDYFVNELYVRYLGRKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M3C3Z7</accession>
    <name>M3C3Z7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_146972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF14966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763087.1">
        <property type="nucleotide sequence ID" value="XM_016903999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C3Z7"/>
    <dbReference type="GeneID" id="27901136"/>
    <dbReference type="HOGENOM" id="CLU_2139537_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF14966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="113" mass="12801" checksum="AEEB480057D28477" modified="2013-05-01" version="1" fragment="single">MNQTINNFKQKGRRLPTPFQEPMAPTKLSKGISKPPRRRQTSLKPLPSHAIFPTENTPSKPFRSSSNSNNNTNITLRISFHKGNFSHWNPTTWQPHTFPGVIDATKPLSDLPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M3C443</accession>
    <name>M3C443_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_147015</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763147.1">
        <property type="nucleotide sequence ID" value="XM_016904030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C443"/>
    <dbReference type="STRING" id="692275.M3C443"/>
    <dbReference type="GeneID" id="27901167"/>
    <dbReference type="eggNOG" id="ENOG502S1ZS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031989_0_1_1"/>
    <dbReference type="OMA" id="TAQKSMQ"/>
    <dbReference type="OrthoDB" id="5393057at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21383">
        <property type="entry name" value="GAT_GGA_Tom1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044836">
        <property type="entry name" value="TOL_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45898:SF4">
        <property type="entry name" value="TARGET OF MYB PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45898">
        <property type="entry name" value="TOM1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50909">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAT" evidence="4">
        <location>
            <begin position="220"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="186"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="312"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="549"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="312"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="356"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="392"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="428"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="465"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF15026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="577" mass="63098" checksum="F974C16CA43A8F99" modified="2013-05-01" version="1">MNKFKGLLGRTKSLRNGSWNNSTKHEDASSDSPEANAPRAIRLFCESGSQNNGGEEVLHLPVIVESAESSPAAAAAAANQIKRFLGKAWSSQPHVQYNAIMLIRILSDNPGPQFTRNFDMSFVSTVKEMLRNCKDQSTQQILRETLDHLENDKANDEGLQGLFYMWRKEKGHAASFSEGGFRGPDMARGSHMPPNGYQQPGLGHERSAGSGRRHRESGLPSAVELASRVEEAKNTAKILLQLVQSTPTEEVLGNELIKEFSERCNTAQKSMQIYINAENPAPDHDTMQTLIETNEQLSLAISRYQRALLAARRAAGASHSPQQDQQSPQEGAHSGYGAFASSSSGPSSLHQQQSSNAFTPAPGTQTNGYYNQGAGENQAYGQQTFGGYQAPAGPPPNRSPAPQIPPSQPQQAVNPFADPEPNQYGAFQPPSQQQRQSQQQQQPPPPPQQQAYHPQTVSFDDFDQQHQPLQHSRTFTIENEPTFAAPNRKNTNELENAYSDDHAKVSPVLTRDEQFVSPASPQRPGLGAYHQSDITQSYVGRQESALNGLTMHGAVGAPTPNDQSNSAYDVSPIETRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M3C4D5</accession>
    <name>M3C4D5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_38254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763267.1">
        <property type="nucleotide sequence ID" value="XM_016908698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C4D5"/>
    <dbReference type="GeneID" id="27905835"/>
    <dbReference type="eggNOG" id="ENOG502SK00">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008019_1_0_1"/>
    <dbReference type="OMA" id="KNCWASP"/>
    <dbReference type="OrthoDB" id="4194555at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF15146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="740" mass="83486" checksum="DC8E4AB116116D27" modified="2013-05-01" version="1">MTSGLIKSQAPLTENSKRSTTVDSIRGHSAILFSREGPAASNEIFDEHAKLRYLPLVPHSDDEQAITKNTDLVILPSHLVRINATTRGPRLCRASWPRDRLPVEIFDMITELLSRDDVKSARLVNREWERKVSGNLFASSVVPFNTELYDMIEEDSKAAHRMPCSAHRPKGKGKAGTIEVPDQGINVGHGLRVFQGFGPYFRRFGMSFEVAEAQLARPPVKKDLDHVTSYYGSYDWPQHEYTRFAGLAGLERTADETLRMKAAFSNLHKVQDLGLSLDNGLGWLNGPDKSIHARIFQHGSPVFGYSRPVPDQQMQDAQVFWQAIQECHAADEDRYGVLYTTFSQLDIAGIYDRSALVPAELRKEQKEWLLETDWAQRAFLECYMLAVIDNPVIFGRVKTLTITKVSSGLLPILSRESFWNALPGVSDVTIHVKPDWRTVERDNAGFAETSQRQPSEAVNTFYKCILRDRLCLRSSITKLNIGWAAGGEHAEGIFARNNHVLPAPITQLEHSTAVNGQVALVFRFVEHLTLHNCWMTPVTFESLLNNHASKALKNLVLDSVSLTAHPRFLAVEPNYRSFFPSPHYSHWSDGHREGSWAQVLDKLSPGKVFRDFLPHVRGREEQLSKRAKTNLQSIEFQSCGYVKLLLNSTFDQHAIDTGTGQSLSAWFHIRQIALLPAMMSTNDRFLGRIAQHMPERELNALRFAWGLREGWNDRAKAEAVEYDGLLAGGHGRFSGRINRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M3C4P1</accession>
    <name>M3C4P1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">TPT-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_147188</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763392.1">
        <property type="nucleotide sequence ID" value="XM_016904138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C4P1"/>
    <dbReference type="STRING" id="692275.M3C4P1"/>
    <dbReference type="GeneID" id="27901275"/>
    <dbReference type="eggNOG" id="KOG1441">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019048_3_0_1"/>
    <dbReference type="OMA" id="DAMSMIP"/>
    <dbReference type="OrthoDB" id="1588579at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="307"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="430"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="10">
        <location>
            <begin position="149"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="477"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="477"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="524"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF15271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="603" mass="65470" checksum="A174A90BD21D6939" modified="2013-05-01" version="1">MVPHATGASERRRSSSSVQSNNTSALQSNKFPDFVQEHAAAAAAAAATNPFDEDVYNDISRGPSPRPLPNGLPPGLHSSERWPARKSRETSSRLLPNGGAGMNAGTKTRHGRQKSLSEAISTVRTRGRGASIHENVHEIAESLKAPVSMKLVGLCAFWYMTSIITNTSSKAILTSLPMPVTLTIIQFALVSFWCVFFAWLAKRNASVRNALPVLKNGIRRPNKEIIMATLPLTAFQIGGHILNSDAMSMIPVSLVHTIKGLSPLMTVMAYRIFLNVRYSVPTYLSLIPLTLGVILACSASFRANFLGLIYAFGSAILFVTQNIVSKKIFTDSARAEADGVPVGRRKPDKLNLLCYSSLMALLFTIPIWFWSEGITLLGDFLYDGSIDLNVRPNSLDHGRLTLEFLFNGTFHFAQSLVAFVLLGMTSPVTYSVASLIKRVAVIVFAIIWFGKPMTRTQGAGFLLTFVGLYLYDRTSDADKRDKQMRERDASANHLLPLNLGDTKKNDAAPAPFTQSPLGLEHSSGQQQHHQQQQQQHGGFNGISGYAHGNYAVGSGPGRPHQNGSVPGANHHGGFPHPSSLAPGTKAQETWSPGDVVVRKSLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>M3C768</accession>
    <name>M3C768_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_147762</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF16101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764222.1">
        <property type="nucleotide sequence ID" value="XM_016904512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C768"/>
    <dbReference type="STRING" id="692275.M3C768"/>
    <dbReference type="GeneID" id="27901649"/>
    <dbReference type="eggNOG" id="ENOG502QYWX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004083_7_2_1"/>
    <dbReference type="OMA" id="RVYPCAA"/>
    <dbReference type="OrthoDB" id="2269373at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF85">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="13"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="46"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="135"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="599"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="100"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF16101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="706" mass="77876" checksum="FFE89C6FF8A89091" modified="2013-05-01" version="1">MDSTPKRDNHTPSCSVCQRRKVKCNRVYPCAACTKSGLECVFPAPGTHGKRKRRNTGHQNAIREPAPKASSAFNAERATPTGTVGVLRRRSVTDLPSPESTGSHGTASGAGTARLVSEGNGFRYVNNHLWDAISSDPHASNGSPGVTPEDPKPSPGVHGVREDDGQKRNSTRSSFIFGNQGNDGSSGRPQAPASQVVFLWQTFQSNVDPVMKISHIPTIQSILLGQIGHAVLPPNDQALVCAIHLISIVSLTNEQCGDSLGESRNSLLEKHRQATETALSAADFITTTDIMVLQALIYYLTALRSLGEVQLAWSLLGIAIRVAGTLGLARDGTSLGLSPFDTEMRRRLWWGLVYFDGRMAEVVGQDGDLMGSNFDARPPSNLNDSDLFPTMTRLPDSRRGPSEAIYLQARVLSITVARSLQSITGPSGTWHRLHDASMPTSEKLETMHHIEQRYNEEILEPCDPTVPLQWLSINTAKTFATKLRLISKIPIVDIDKEWENADGFSENAFILSMDLLQIQLNLWCEPSVQLWRWHWQAHFQWYALVTLLRQTRLRRSGNGASRAWTLIRKVFDIIIPSLELGPKRSMLIDGIHSLLNAAKQQQEMPSQQPPPSNSDQRLPMMSTAEVVAAPETGNVTHDDTPSATSYESQARTRVLPVSDMIQEMPPPDAFDQPFYKNWPDPVLGGLDLTAIDWVEFDRLAAELAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M3C811</accession>
    <name>M3C811_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="2">1.1.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ketopantoate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_152332</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="2"/>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF08030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756151.1">
        <property type="nucleotide sequence ID" value="XM_016907382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C811"/>
    <dbReference type="STRING" id="692275.M3C811"/>
    <dbReference type="GeneID" id="27904519"/>
    <dbReference type="eggNOG" id="ENOG502QPT5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031468_10_3_1"/>
    <dbReference type="OMA" id="NTSKRLW"/>
    <dbReference type="OrthoDB" id="73846at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050838">
        <property type="entry name" value="Ketopantoate_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765:SF2">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="7">
        <location>
            <begin position="191"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="8">
        <location>
            <begin position="368"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="167"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="309"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF08030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="519" mass="56795" checksum="179B9A950F368FC6" modified="2013-05-01" version="1">MATKAKAQEEQHAMGSGSGRGEGGGGGGEGGVAEEQVDARTMEALRAAMSPADRQYAAQKNVPRRIHIVGTGSIGKLVAHSLRGIPDPPPVTLIFHRYKLLQAWNWSSKVITVQDGEFTVPRGGFDVELAPEARVQYGNVLQEGKPDVYSLSDQTGLKPHQVAKIVADQQRESAKPDGEEEAQEKKVDSKPVAAEEPQSPSRKPQPGDYPTSDEPIHNLIVCTKTIRTVAALAALRHRITKDTTICFLQNGMGVIDDINTTLFPDESTRPQYLQGIVTHGANVPLQKALADPFFVVHAGHGTIALGAVVPPKSHSRPATPTGYGTENPGKLDEKDVNELQPTGRYIVRTLTRAPVLQCVAFTPLELFQLQLEKVAINSVLNPLTALLDNRNGTILYTFALTRTMRLMIAETSLIIRSLPELRGIPNVPNRFSAERLETLVVSVANQTRDNISSMLADVRRGAQTEIEYINGYIIKRGEEMNIKAIVNYAIMQVVVGKALMSQREYESEVPMQKRDVNRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M3CA54</accession>
    <name>M3CA54_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_151691</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic/archaeal PrmC-related family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756861.1">
        <property type="nucleotide sequence ID" value="XM_016906983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CA54"/>
    <dbReference type="STRING" id="692275.M3CA54"/>
    <dbReference type="GeneID" id="27904120"/>
    <dbReference type="eggNOG" id="KOG3191">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018398_6_1_1"/>
    <dbReference type="OMA" id="DVNRNAC"/>
    <dbReference type="OrthoDB" id="25896at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035657">
        <property type="term" value="C:eRF1 methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000274">
        <property type="entry name" value="ERF1 methyltransferase catalytic subunit MTQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052190">
        <property type="entry name" value="Euk-Arch_PrmC-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45875">
        <property type="entry name" value="METHYLTRANSFERASE N6AMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45875:SF1">
        <property type="entry name" value="METHYLTRANSFERASE N6AMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF08740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="250" mass="27295" checksum="2FB272453B3E196B" modified="2013-05-01" version="1">MLPTPSTSHVNYAHIYEPAEDSYLLLDTLSSSSEATFLHNRFPATAPSPLVLEVGPGSGVVLAFATANANHIIGRIDAVSIGVDVNPFACTATAQTVQGAIKDAHPGKTANFLDSICGDLTTCLRPSSVDVLIFNPPYVPTEELPAQWNDQSDYQSLSRTARFDRDSHLLSLSYAGGADGMETTDRLLEQIPEVLSHRGVAYILLCKQNRPEEVARRVRSWPRSWQAEIVSSSGKSAGWEKLCILRIWRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M3CAI2</accession>
    <name>M3CAI2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Metallo-hydrolase/oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_93060</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(3R)-atrochrysone 2-carbonyl-[ACP] + H2O = (3R)-atrochrysone 2-carboxylate + holo-[ACP] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:64236"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:20479"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:234107"/>
            <dbReference type="ChEBI" id="CHEBI:234110"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:64237"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756976.1">
        <property type="nucleotide sequence ID" value="XM_016910602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CAI2"/>
    <dbReference type="STRING" id="692275.M3CAI2"/>
    <dbReference type="GeneID" id="27907739"/>
    <dbReference type="eggNOG" id="KOG0813">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048478_1_3_1"/>
    <dbReference type="OMA" id="GDHVMAW"/>
    <dbReference type="OrthoDB" id="17458at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07722">
        <property type="entry name" value="LACTB2-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000041">
        <property type="entry name" value="Metallo-beta-lactamase domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047921">
        <property type="entry name" value="LACTB2-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041516">
        <property type="entry name" value="LACTB2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050662">
        <property type="entry name" value="Sec-metab_biosynth-thioest"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131">
        <property type="entry name" value="ENDORIBONUCLEASE LACTB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131:SF0">
        <property type="entry name" value="ENDORIBONUCLEASE LACTB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17778">
        <property type="entry name" value="WHD_BLACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="7">
        <location>
            <begin position="34"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF08855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="299" mass="33361" checksum="F4DC19B1520F061A" modified="2013-05-01" version="1">MGIESLPPLDPITRLSPRVIRILGGNPSKFTLQGTNTHLVGTGSERILIDTAEGLSVWRERLERVLKDEEGKKEGKVKITKVLLTHWHHDHVGGVDDVRDLLGEDGVEVWKDEKKKKTKIHKIKPNQTFSVPGAHLTAIFTPGHTSDHMSFFLREEDALFAGDNVLGHGTAVFEDLKEYMESLERMQKVAGGRVYPSHGEVVEDGLGKIGEYIAHRRQREMEALEVLGRKEGGPGGDGWWGSMEMVKVVYAAYPEEYWGPAEGSLKQVLKKLERDGKVRQGKGRDGEDGKWALIEKSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M3CEF6</accession>
    <name>M3CEF6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">IMP-specific 5'-nucleotidase 1</fullName>
            <ecNumber evidence="12">3.1.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_150370</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">IMP-specific 5'-nucleotidase involved in IMP (inositol monophosphate) degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>IMP + H2O = inosine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:27718"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="3.1.3.99"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ISN1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.-" evidence="12"/>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759552.1">
        <property type="nucleotide sequence ID" value="XM_016906123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CEF6"/>
    <dbReference type="STRING" id="692275.M3CEF6"/>
    <dbReference type="GeneID" id="27903260"/>
    <dbReference type="eggNOG" id="ENOG502QR24">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031816_1_0_1"/>
    <dbReference type="OMA" id="WGVLACQ"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006190">
        <property type="term" value="P:inosine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071590">
        <property type="term" value="P:nicotinamide riboside biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071592">
        <property type="term" value="P:nicotinic acid riboside biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009453">
        <property type="entry name" value="ISN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28213">
        <property type="entry name" value="IMP-SPECIFIC 5'-NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28213:SF1">
        <property type="entry name" value="IMP-SPECIFIC 5'-NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06437">
        <property type="entry name" value="ISN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028836">
        <property type="entry name" value="ISN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR028836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF11431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="414" mass="46572" checksum="B4492A1043F2CB5D" modified="2013-05-01" version="1">MTTRYRVEYALKTHRRDQFIEWIKGLLAVPFVLLSQPTNIHEADKPSVANMAKSAHLRYAQIMQDVEELLVDHIAHQKKGKENRSKLKLLVPSIGTFFTPLPLQDAFDWQDKKRFISSRRFVAPSFNDIRLILNTAQAMSLMRSGKLELVTFDGDVTLYDDGHNLSPDNPVIERILALMRNGTRIGIVTAAGYTEAEKYYQRLFGLLDAVAAESHNLDLNNRLVVMGGEANFLFRFDTSAPHKLQPISYDEWRLPEMKNWTEENIADLLDVAEAALKDCVQAMHMPVQVLRKERAVGIYPPKGKLSREQLEETVLVVQRILEMSDAGKRIPFCAFNGGNDVFVDIGDKSWGVMACQSYFGGIEGSRSLHVGDQFLSAGANDFKARLASTTAWIANPAETVNLLDEILEMGEASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M3CH17</accession>
    <name>M3CH17_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_116177</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761234.1">
        <property type="nucleotide sequence ID" value="XM_016901237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CH17"/>
    <dbReference type="STRING" id="692275.M3CH17"/>
    <dbReference type="GeneID" id="27898374"/>
    <dbReference type="eggNOG" id="ENOG502STQS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010595_2_1_1"/>
    <dbReference type="OMA" id="IVELNWH"/>
    <dbReference type="OrthoDB" id="10017101at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF13113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="342" mass="38567" checksum="C779C5415B119A97" modified="2013-05-01" version="1">MATPNPPPNSNSAPEITYCSNNPTYHNNKDAAYILPNDQVEHARLEEQARHLLAIMNNEIIHSPIPTSIGPGAKMLDVGCGTGIATDFIGSKFPLAEVYGLDISPVPIHVRANRPSNVRFLTGNFMVDEPGEWYSSVVVQGNENEEETYFPLSRTSCCSSSSSSSFDLIFSRFLVCGMTHWPQYISRIHHLLKPGTGYIELQDLDFTWYNKNHQPISHTWKWLQAVKTAALENGMDWSCASKFPQWLADAGFQDVVVKKYKCPHGSVGLEGGGEENQKWRAWGEFIAKQQAGLVWYFLPRMLASKGYSEEEIEGFRKEAMKCFEVTEEKYWVMSVVVGRKGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M3CKT5</accession>
    <name>M3CKT5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_115654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762499.1">
        <property type="nucleotide sequence ID" value="XM_016901188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CKT5"/>
    <dbReference type="GeneID" id="27898325"/>
    <dbReference type="HOGENOM" id="CLU_2832822_0_0_1"/>
    <dbReference type="OrthoDB" id="5417628at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF14378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="66" mass="7784" checksum="50F7482E2A1FFB0C" modified="2013-05-01" version="1">MRAFLKAFLKDKPEWPYWPVLSLFFADNVRNRRCCDRERVNQEAAARKAVLRESQPDEPPPPPSQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M3CKW7</accession>
    <name>M3CKW7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_148119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762524.1">
        <property type="nucleotide sequence ID" value="XM_016904718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CKW7"/>
    <dbReference type="GeneID" id="27901855"/>
    <dbReference type="HOGENOM" id="CLU_1918401_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF14403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="132" mass="14600" checksum="7F285E0A961AC71F" modified="2013-05-01" version="1">MPPPPPLNLRPAMYSTLYFSLANTTTVSFTDHANVALFSLGTGLGQVLVLFFATFRMSKSTRMSVEARSTMIGGWRGRRKRRPVVTSGGLYLQASFLRIGGYIYTHSESGNQQMVGLRPTARCDMFGIPFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>M3CLW0</accession>
    <name>M3CLW0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_116034</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762894.1">
        <property type="nucleotide sequence ID" value="XM_016901218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CLW0"/>
    <dbReference type="GeneID" id="27898355"/>
    <dbReference type="HOGENOM" id="CLU_1235713_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF14773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="224" mass="24364" checksum="AD2A3C67ADDC0692" modified="2013-05-01" version="1">MSVAKSAGLEKRLTLIFDTKLTEQCIQRSDSRSTYIHVFFMVLFTAPPSEYSTVFAIPKSFKGTIEFINSKRLKNDLASTTPDDQLSNATKAKLAAEKLYKTLKSDARIGPLGGLRRAAAGFNLSLSSSRCPGDDGSGWNPMSEEFLGTIDFGRDVMETLAALAADNGGAWNPMFETILRLLSTLSTRTELQRGRPRQPRPGGAPVAALYGKMGGGYGRDLENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M3CNX3</accession>
    <name>M3CNX3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_147352</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763594.1">
        <property type="nucleotide sequence ID" value="XM_016904243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CNX3"/>
    <dbReference type="STRING" id="692275.M3CNX3"/>
    <dbReference type="GeneID" id="27901380"/>
    <dbReference type="eggNOG" id="KOG1205">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_9_1"/>
    <dbReference type="OMA" id="VRTTHCL"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF15473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="279" mass="30628" checksum="AE78CBF524FF2A43" modified="2013-05-01" version="1">MAPQVFFITGTSTGFGNELVKKALKEGDKVVATARNSSKLKFDGATNDNFLAVDLDVTDTASVDKAFDAALKKFGRIDVVTNNAGYGLSGEFESVSDKQARTQMEVNFFGLIHVTRKALKIMREVNKPAGGKIQQITSIGGQRGVPTFSIYCASKWAVEGFTEALSHELKPEWNIKLTCIEPGGFRTDWAGRSMVFGEQKEAAYDHIDAKTQMGKRHGTQAGDPAKGGRAMWEIAHMENPPLRVVIGSDAYKAIMQKIKDYGELYPKYEKLSNSTDVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M3CPV2</accession>
    <name>M3CPV2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glycoside hydrolase family 16 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_37926</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKN1/KRE6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763879.1">
        <property type="nucleotide sequence ID" value="XM_016908687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CPV2"/>
    <dbReference type="STRING" id="692275.M3CPV2"/>
    <dbReference type="GeneID" id="27905824"/>
    <dbReference type="eggNOG" id="ENOG502QR13">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010811_4_3_1"/>
    <dbReference type="OMA" id="TAPFDDY"/>
    <dbReference type="OrthoDB" id="412647at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02180">
        <property type="entry name" value="GH16_fungal_KRE6_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005629">
        <property type="entry name" value="Skn1/Kre6/Sbg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361:SF14">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03935">
        <property type="entry name" value="SKN1_KRE6_Sbg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="10">
        <location>
            <begin position="86"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF15758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="510" mass="57704" checksum="AB3DCB03D86BAB4E" modified="2013-05-01" version="1">MDEKEDDDDMHMPAWDDDRKYRPKFRERFAKENIVNTIGIVFLLIGLCTIFIVLPVISITGTALIPYNNDTPLDQMPGHGKPDPWTHVNDNDYPLLANIRTGLVDPDTPSSAMTRKSIKGDELKLVFSDEFNKRNRTFYEGDDPYWFAPDIWYHATNDLEWYDPDAVNTGDGTLQIQLDAFANHNLQYRSGMLNSWNQLCFKGGVFEVSVSLPGPAGIHGLWPGAWTMGNLGRPGYLATTDGMWPYTYNDCDSGITPNQSMTDGTSYLPGQRLPNCVCQNEDHPSPGTGRGAPEIDIIEASADWAGKGFGVATQSYQVAPFDIFYEPNYEFMEIPNYNFSYVNSYTGGPFQQAVSTTTMLNNDWYDGKAYQKYAFEYQPGSGKNAHVTWFVGDDEMMRFDARAIGPNGNIQQRLIAEEPLSMILNLGFSHSWVDIDQANLRFPTTMRIDYVRWYQNEADAGHEVTCDPQGYPTTEYIARHPEAYKNPNYTLWSDAGYQWPKNTLMHGCSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M3CUX4</accession>
    <name>M3CUX4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carbohydrate-binding module family 18 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_54605</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF07947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756068.1">
        <property type="nucleotide sequence ID" value="XM_016909309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CUX4"/>
    <dbReference type="STRING" id="692275.M3CUX4"/>
    <dbReference type="GeneID" id="27906446"/>
    <dbReference type="eggNOG" id="ENOG502QPS4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009630_1_0_1"/>
    <dbReference type="OMA" id="NKPNPGQ"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11618">
        <property type="entry name" value="ChtBD1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.80">
        <property type="entry name" value="Galactose oxidase/kelch, beta-propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001002">
        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037293">
        <property type="entry name" value="Gal_Oxidase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009880">
        <property type="entry name" value="Glyoxal_oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015202">
        <property type="entry name" value="GO-like_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208:SF21">
        <property type="entry name" value="LOW QUALITY PROTEIN: ALDEHYDE OXIDASE GLOX-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00187">
        <property type="entry name" value="Chitin_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07250">
        <property type="entry name" value="Glyoxal_oxid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09118">
        <property type="entry name" value="GO-like_E_set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00270">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50941">
        <property type="entry name" value="CHIT_BIND_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Chitin-binding type-1" evidence="5">
        <location>
            <begin position="27"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="365"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="563"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="667"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="372"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="571"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="678"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF07947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="715" mass="76909" checksum="92714F1784DF0CEA" modified="2013-05-01" version="1">MLDNEPTLGAPSPTSSAPQSTGPVTTDGSCGANHNNAICGNWHLGSCCSMYGFCGNSTSHCGEGCQSGPCSQSPTIPVPEPSPAPPNPHPGSFKIVGDSGVPAMHAALMPNGRVVFLDKVENYTRLKLADGYFAYSSEYDPATNEVVPLSYKTNAFCAGGAFLANGTLLAVGGNGNLSWLDPTVMDGWRGIRYLTRSASDNSSNGANWVEPGHQLDTARWYPSVQTLPDGTIFVASGSLNGLDPAQHANNNPTYEILDQNGITQGHSIPMEILVKSQPYYMYPFIHLLPDGNLFIFVSKSSEIFNFSSNTTIQSLPDLPGEYRTYPNTGTSVLLPLSSSNNWSAEILICGGGAYQDLTSPTDASCGRITPLSSSSSSSKDSNNNNNNNNNNNNNNKTPTWELDSLPQGRTMLDNILLPDGTILFLNGAHVGSQGFGLADDPLLQVLIYEPSAPFGSRWTTGAKSTIPRLYHSIAMLLLDGSVLVAGSNPNEMPVVDDDRSKSDKGNFFQTEFRTERYFPSYFSGSDSSDSSRPGNVLLSTLELYSNHSEFQISFQLPPSTTAAAAASVSAAEEDENENENENNTKPPAPKIQISLHHNGFITHSLHMNQRMLDHPTHEKTQNLQQQKTLRVRMPPTPNLAPPGPYVVYVVVNGVPAVGQMVMVRTGTEAGEDEDEGEGGQRKKGEAGKRLFGKERRSKVRVWGVAGLVGLVGRWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M3CV67</accession>
    <name>M3CV67_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Siroheme synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SEPMUDRAFT_152342</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Siroheme synthase involved in methionine biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>uroporphyrinogen III + 2 S-adenosyl-L-methionine = precorrin-2 + 2 S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32459"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58827"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.107"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF08042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756163.1">
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0016491">
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0004851">
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0032259">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
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        <property type="entry name" value="4pyrrol_Mease"/>
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        <property type="entry name" value="4pyrrol_Methylase_sf"/>
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        <property type="entry name" value="4pyrrole_Mease_sub1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SUMT_yeast"/>
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    </dbReference>
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        <property type="entry name" value="Siroheme synthase middle domains-like"/>
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    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
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    </dbReference>
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        <property type="entry name" value="SUMT_2"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="8" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="2 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
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    <keyword evidence="9" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Siroheme synthase central" evidence="15">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Siroheme biosynthesis protein Met8 C-terminal" evidence="14">
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            <begin position="212"/>
            <end position="255"/>
        </location>
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            <begin position="281"/>
            <end position="491"/>
        </location>
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    </evidence>
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    </evidence>
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        </source>
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        <source>
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            <dbReference type="Pfam" id="PF00590"/>
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            <dbReference type="Pfam" id="PF14823"/>
        </source>
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            <dbReference type="Pfam" id="PF14824"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMF08042.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="571" mass="62008" checksum="BA68F12A953F3D3D" modified="2013-05-01" version="1">MSPALLTAVDSTAHIHLIVGSNPLAGARISRAIEVGAIPILIAPESTSVHYGLAKRIEEHAVRWHKREFQDSDLTTLGRDEVDHVVDAVFVTSGGKTAFGTRISTLCRRLRIPVNVADAPNLCTFTLLATHTSGPLQIGVSTSRKGCKLASRIRREIAAALPHELGPAIDRLGTLRRRIWEQDHANEGEGELEAEDEETGQSAEFNKLVMPSDAEAAKARRMRWLSQICEYWPLRRLAAITDEDIEQILQAYKQEAQSTQSDDSKPPLNAALIDSRRLRGRIILAGSGPGHPDLLTTATLKAIRSADLILADKLVPERVLDLIPRRTPVHIARKFTGNADQAQDELHSLGLEGLQQGKTVLRLKQGDPYLYGRGAEEVTFFRQHGYEAVVLPGVTSALSAPLFAQIPVTHRSVSDQVLVCTGTGRKGASPNPPSYLSNQTVVFLMGLHRLQDLVTSLVEHKTTPYPVTTPCAIVERASCPDQKVVRTTLEHVVAAFEEEGSTPPGLLVVGAACEVLKKNPQKWVVEVGFQGLDALDGLGENGNGLDELRDALLTPGLEEPIKTLSALPVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M3CW52</accession>
    <name>M3CW52_SPHMS</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_121751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
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    </dbReference>
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        <location>
            <begin position="33"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF07901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="398" mass="45322" checksum="BA550489751E8EBB" modified="2013-05-01" version="1">MPKRKNVTPEALENKRARLGAAAKSLEEYSLKPNTLRERERTAAMDEEKRAQDRHRKARNESFARFKKAQIKQSSEFSELSRDRQAALVEEWRSMHTAEYDRKAAKKQAETDPALSPDEQAEIDEADWFLELGDSESKSKITFQKEDQVEWEWDTLTLGERCDKALGGLGNECLPQETILNPLSSKEIDKETANSVGTFAFQAASSTFATAHNQWHRSIRKFWNKLVALESLVLPDEAAMKQISQIVDSETKKICVREVRLPLPHEIFSPIERAVCRSILAWDVAAQRAYSSGLPGPSWLIPENYNYSANGFLPSVSLKGEKHLAKMAYKLCERENTLSREQTLWPEIMAALIECNVKEYNGITLEAFLLPLLREDELCLASSGIEKEPRLFQEDEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M3CWW8</accession>
    <name>M3CWW8_SPHMS</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_111940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EMF08617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016900949.1"/>
    </dbReference>
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    <dbReference type="STRING" id="692275.M3CWW8"/>
    <dbReference type="GeneID" id="27898086"/>
    <dbReference type="eggNOG" id="ENOG502SCE7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_650810_0_0_1"/>
    <dbReference type="OrthoDB" id="5279705at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="397"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF08617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="422" mass="47138" checksum="AEF4A647E5129B26" modified="2013-05-01" version="1">MHKVRYIHVWDEVELYDVKSIDGNNFRPDGKSDRVSFVTVTRQHLRSTRPPPSPPPPLPSPDDNNDENKAQCVFESKMLAFAPSSSSSSSSSSPNYAYVPSPLSPRSANIYGVRRHQFQQSASSSSSFSYNHMSTNEPHGKSISRNGSNPRDDEENFPQPVAAAAAVTITNTTNSSSSSSSSRIPFSQRPIKRPPFQHQLRAPSALHTGRRDAYLRKIALRRDEARFETRGEDMMRWDFMQRQRAWEAERAREAALAASDYLAEEEEEEEEEEEYEHEHEHDDGVVDDGYDEYDLPVASGQMNGLQRSSMANSATRSVSQEAEVEEFLREEGKELEALLEHLPPTGEEYGDDDAMNQEEGNEFDETSLWSDDADYDALFEEVLSQQEQAGGNAAVAAAAQSSQVISDAQHGLVGGDDEMDMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M3CXL0</accession>
    <name>M3CXL0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein P1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">60S acidic ribosomal protein P1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_152077</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays an important role in the elongation step of protein synthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">P1 and P2 exist as dimers at the large ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756517.1">
        <property type="nucleotide sequence ID" value="XM_016907229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CXL0"/>
    <dbReference type="STRING" id="692275.M3CXL0"/>
    <dbReference type="GeneID" id="27904366"/>
    <dbReference type="eggNOG" id="KOG1762">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114656_1_0_1"/>
    <dbReference type="OMA" id="REELMCV"/>
    <dbReference type="OrthoDB" id="2194681at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05831">
        <property type="entry name" value="Ribosomal_P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000001">
        <property type="entry name" value="60S acidic ribosomal protein P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696:SF10">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="66"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF08396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="113" mass="11280" checksum="A21E742F7E0D310B" modified="2013-05-01" version="1">MSTSELAVSYAALILADEGLEITADKLQSLISAAKVPDVEPIWTTLFAKALEGKDVKDLLTNVGSGGGAAPAAAGGAAPAAGGDAAAADAPAEKAKEEEKEESDDDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M3D0H3</accession>
    <name>M3D0H3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_150059</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759144.1">
        <property type="nucleotide sequence ID" value="XM_016905941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D0H3"/>
    <dbReference type="STRING" id="692275.M3D0H3"/>
    <dbReference type="GeneID" id="27903078"/>
    <dbReference type="eggNOG" id="ENOG502S2YR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010168_2_0_1"/>
    <dbReference type="OMA" id="FSEMPGI"/>
    <dbReference type="OrthoDB" id="5367584at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024312">
        <property type="entry name" value="TACC_fungi"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12709">
        <property type="entry name" value="Fungal_TACC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="233"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="695"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="393"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="556"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="125"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="166"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="701"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF11023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="753" mass="82217" checksum="45130C501432744B" modified="2013-05-01" version="1">MDSPLAPRMVEESALAFDHNEPSSPFMTEAESRLISKTWDAPIDTEHMSDAEQPQQQPQQQTPMEMFATPRKPNFEDCMDDKENVPQDKDNNNNNNNNNTIQKIPRPATPPERKALPESPRASRARKESMTDARRGSADGDQMPPPPPSTCKPQTPKRSPLKPSRSAANGQTPRASATTRSNSFESELTRTTTRASNDNFEVRTIQQYTHVEENSGVDDTGFSAFSEVPDMTTWAKMGQSPAKRGDSLRTPGKMADATPRTSRKRPSPSRSPSPTPRRAKNGHERSTSQDGTTYLIDFTQQMDHMGGYGRHTSPAKSTTQPDLLKFMNNQRSPHKTARQSWATPAKQSNIMNLLDFELPPAPTPRSIPTITVRELESLKSSYLSQISSLKATLSGREAEVESLKRAVGDAERRVGEAQESLREEKNRCEYAEEQKAGWEKRGQEVEYLLKEVKEEVMKSEAEKEELLRKVEEFERRSEDAEARAVKAEERFADALAARAASGEAGGDIDPNAMEEQVQRLVAAQIDSKIEAVSRELHSVYKEKHERKVATLKKSYEARGEKKCAELQARLHELEKQHEDLLAAKDATFSGPVAAASSGEAEAELKFQIEEQRAQFARLEAEISTSRQYQAQLERELAQERIEKGDLVAAVDEMLLLQSEQGGGGSAQGAMSVVQDFRKSISSRPASSLSGAAAATSSGLRAPGGGAAPAAAGGIGSRIGGVGRPGGSGIAKGGGGGMMSRIEKMGASARTGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M3D1L6</accession>
    <name>M3D1L6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Lysosomal dipeptide transporter MFSD1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Major facilitator superfamily domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">SEPMUDRAFT_164902</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79415"/>
            <dbReference type="ChEBI" id="CHEBI:192470"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)</text>
            <dbReference type="Rhea" id="RHEA:79367"/>
            <dbReference type="ChEBI" id="CHEBI:229968"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)</text>
            <dbReference type="Rhea" id="RHEA:79375"/>
            <dbReference type="ChEBI" id="CHEBI:229967"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79383"/>
            <dbReference type="ChEBI" id="CHEBI:229966"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79371"/>
            <dbReference type="ChEBI" id="CHEBI:84315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-arginyl-glycine(out) = L-arginyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79391"/>
            <dbReference type="ChEBI" id="CHEBI:229955"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79411"/>
            <dbReference type="ChEBI" id="CHEBI:229953"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79379"/>
            <dbReference type="ChEBI" id="CHEBI:229964"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-histidyl-glycine(out) = L-histidyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79395"/>
            <dbReference type="ChEBI" id="CHEBI:229957"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)</text>
            <dbReference type="Rhea" id="RHEA:79399"/>
            <dbReference type="ChEBI" id="CHEBI:229954"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79387"/>
            <dbReference type="ChEBI" id="CHEBI:229965"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79403"/>
            <dbReference type="ChEBI" id="CHEBI:229956"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-lysyl-glycine(out) = L-lysyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79407"/>
            <dbReference type="ChEBI" id="CHEBI:191202"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="18">Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759514.1">
        <property type="nucleotide sequence ID" value="XM_016908138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D1L6"/>
    <dbReference type="STRING" id="692275.M3D1L6"/>
    <dbReference type="GeneID" id="27905275"/>
    <dbReference type="eggNOG" id="KOG4686">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024516_1_1_1"/>
    <dbReference type="OMA" id="FSWVYWT"/>
    <dbReference type="OrthoDB" id="424834at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052187">
        <property type="entry name" value="MFSD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23512">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23512:SF12">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="19" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="385"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="420"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="485"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="20">
        <location>
            <begin position="39"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00044876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00045018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00045709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00046376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EMF11393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="512" mass="56132" checksum="40BB7A21DCCC7D3A" modified="2013-05-01" version="1">MPKKEPGVFDIAAVSDDALSIRSARGRSTHVPMRMKIIAVLMVSLIGFGSKWSSGVTGAMKSTLKKELHIDNTQYSVLEASQDFMVTVLMLFTGLLTDRFGGAGIMVWGNIVYSLGSIIIAAATTVRSYKLMIGGIVVQSFGDIATQVAQYRIFSSWFAPSDGFASTLGLELAIGKIGQFVGTATANPIAKGTGDFSWVYWTAVFMNIFTNFATGAFYYFRKYCDKHYSDGIEDPATGEKLRENTKKFEIKKALHLPMAFWGFICFSTFQTSMAVVFAQNATELAEQRFDVDGTKAGWYTASARYLGFFLVPLLGAFIDWYGNRLTVLLICGLTCFCAMCLAAFGPTVSGTAAAFGVYAIGSTLGPTSIIDGVRTSIWYQDTFGVAYAIKVVVNNSMNIVIRILTGVIQDHDDNSYNHVVIVYVILAAGAVVVSVTLFVWSFFTNDLRRLQWTRKERQRSGEEINSQREAYETGRKLGLNRKVSAGFFSALLVLILGAWAAYFWGLATGNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M3D3W3</accession>
    <name>M3D3W3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_45061</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761011.1">
        <property type="nucleotide sequence ID" value="XM_016908948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D3W3"/>
    <dbReference type="STRING" id="692275.M3D3W3"/>
    <dbReference type="GeneID" id="27906085"/>
    <dbReference type="HOGENOM" id="CLU_090929_1_0_1"/>
    <dbReference type="OMA" id="EMLHARI"/>
    <dbReference type="OrthoDB" id="3724345at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="entry name" value="dinb family like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018531">
        <property type="entry name" value="DUF1993"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36922">
        <property type="entry name" value="BLL2446 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36922:SF1">
        <property type="entry name" value="DUF1993 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09351">
        <property type="entry name" value="DUF1993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="DinB/YfiT-like putative metalloenzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF12890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="188" mass="21535" checksum="48710E7AE0147DEF" modified="2013-05-01" version="1">MGEFPVYGNPTPTNFRLTTYDLTVPIMIRSLQRLLGCLKKGEQWAKDNNRSIEEMLHARIYQGAKPLAFYIIGASNTAGNLLSRIGGESQIYLIDDLLHKSTLKELYDRLEFQILRLHSANKSLFMGPNDKCKVTLRGHQANFRVLTYIQNYALPDYFFHQNSAYCLFRMQGVPLTKMDILGAEEDHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M3D4E6</accession>
    <name>M3D4E6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_148455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761201.1">
        <property type="nucleotide sequence ID" value="XM_016904940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D4E6"/>
    <dbReference type="STRING" id="692275.M3D4E6"/>
    <dbReference type="GeneID" id="27902077"/>
    <dbReference type="eggNOG" id="ENOG502S6XE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035263_1_1_1"/>
    <dbReference type="OMA" id="WINQNAF"/>
    <dbReference type="OrthoDB" id="3350591at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022085">
        <property type="entry name" value="OpdG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053204">
        <property type="entry name" value="Oxopyrrolidines_Biosynth-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12311">
        <property type="entry name" value="DUF3632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF13080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="271" mass="29698" checksum="95AFAF81EBC5F507" modified="2013-05-01" version="1">MPQKSAFAAPEKVQQSPQYAALEGLTTGAAEASPLQRFCAPVEQKLQSSSPSDDVEGELYKGWIAVMSRAAATSYTEGGRSALAAFLVSLTQKRADGQQANSDYGVVHGMKVWQDLPLFGWQVRDAWNFAPADDKSPALSEEWTNVNAFIATLVSELHDKAHSNPDLSVFGLWTIRDALEEDNISDSALAAASVWFIYAAPTLLSWSKEQKSYEGNVARGGFAHKDAGWTGYSPARWAVWQQRLSSLQEEVKEEGTRELVKRAIETIGKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M3D4Q9</accession>
    <name>M3D4Q9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_117401</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760975.1">
        <property type="nucleotide sequence ID" value="XM_016901335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D4Q9"/>
    <dbReference type="STRING" id="692275.M3D4Q9"/>
    <dbReference type="GeneID" id="27898472"/>
    <dbReference type="eggNOG" id="KOG0605">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1714437_0_0_1"/>
    <dbReference type="OrthoDB" id="3638488at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF400">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CBK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="22"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF12854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="153" mass="16801" checksum="6D9D2E853DB60A71" modified="2013-05-01" version="1">MRCLKASAMQRHEIKGVNIAGFDVIRVLGKGSFGVVRLVTERPASADDGSSPARNFSPVNGTAKRNLPSGKPLSDVFAMKVIRKSDMLRAAQEGHLRAERDFLVAAEGSRWVVPLIASFQDNTNLYLVMEYMIGGDFLGLLLREDVLEESHAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M3D7D1</accession>
    <name>M3D7D1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycosyltransferase family 90 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_163404</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 90 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761905.1">
        <property type="nucleotide sequence ID" value="XM_016908052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D7D1"/>
    <dbReference type="GeneID" id="27905189"/>
    <dbReference type="eggNOG" id="ENOG502S0WR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005027_1_0_1"/>
    <dbReference type="OMA" id="ECAPAGY"/>
    <dbReference type="OrthoDB" id="541052at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF35">
        <property type="entry name" value="PROTEIN O-GLUCOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="5">
        <location>
            <begin position="592"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="498"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="508"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF13784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="903" mass="102634" checksum="D4A45368ADDA186B" modified="2013-05-01" version="1">MPEDVTHASSQRKLRILFLALVTLICLRVEVLRQVVDNVQCATKHWNYWIPLVFAAWEFWTTTAPRRSGLVVEDEDPDEITWLDKVVVLPYAQVVATLAVAVGGWLALDAVSSPTSTYICAVSFRYWAKIPWIQRLASLIDVGIVFTLDQLLTSKQAKKLLSIANRFALVGAALLIAAGFWLVVGGVYWYVQETGRKWLATIPQVYFWSVVRLNVYIVLTLVCALLAVHHIGILSASLIATFTSVLTTATATAWNNAHPFPPMRIGSAFVGILLLLIGIWFHFRVASSIQHSHAAHAISAERLLHRVPTWMHVVLSAFMFLWLGLWLSYHKEVSFHPIDMLMYEAEARHEAFVAQAASSKSLAEAVQEYRARYRRHPPPGFDDWYNFATSRNSSVIDDFDNVYRDLLPFHTLTPAELRERTWTLISNPWNDVVGISIRDGQAAISPNVVPTHMWMLEGIVGMISKFADKLPDMDLAFNLNDECRVSVPYEVIEPMRRAGRQAHMPDQANRSWSPSRSNQWKPIPEQPLVLTPLAEASWEPIFHRFGNQGCLPSSAARTQRRWDRSSYCRSCAHPHSMGAFIANWTIAGDICHQPDLADLHGFYLSPAAFKASTYLFPIFSQSRAGGFNDILYPSAWNYLDKARYDPNPDHPDPSFAEKKSVLFWRGATSEGFSHEGNTGQWRGMTRQRFVHLANNINSTTPHEHLLIKSPANPDKLTYQNFAISQLSSVLVTDVHFVESIVRCGGRDCGDQDHEFSPLFTPLDFQSHWQYKYLLDLDGAGFSGRFLPFLKSNSLPFKAALFREWWDDRVQAWIHFVPLDLRGQGLWATLAYFQGLSAKFPGMKQDVVVDAHQREAERIARQGREWADQVLRKEDMEIYMFRLLLEWGRLTDDGREELGFTLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M3D7S4</accession>
    <name>M3D7S4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_148010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762356.1">
        <property type="nucleotide sequence ID" value="XM_016904647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D7S4"/>
    <dbReference type="STRING" id="692275.M3D7S4"/>
    <dbReference type="GeneID" id="27901784"/>
    <dbReference type="eggNOG" id="ENOG502SDY1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_504495_0_0_1"/>
    <dbReference type="OMA" id="GQREMTK"/>
    <dbReference type="OrthoDB" id="5364171at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF14235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="540" mass="60488" checksum="A3667987BBD59C3B" modified="2013-05-01" version="1">MPEKDKLSWLTPKRRKTTGSVKTISHGQMRTVAEQDESQAAELDASLPEPASLSAQRSIQASKEHGRDDNDTAVQLAQMLRLTEMNADSVSRLASRMGNNQHDHGGYFDTSALAVHFGRMTDLLARNIEHMESMSQKQSEHEQRLTAALEDISTKRKEDRIDLAQLSAHLDRVNKTLDRSPTPRKDSVRLAADDSRPSIDFSPLVWRLEQMQHAIEQNNALTAELLEERSTADAEARYKNQLDLLPISESLEKIYGAVEKQNLHTNALLEILRDDKDDSLQTAKANGETLDRILQAQMETKEAVEHNGGDVDFEPVARHMDAIREVATENTEQIRILVECQKDHNQSKPIGRPESLNLDFSPMTDRLDRVHATLEKSTSHLQTQTPGTGDMKFLMSALASHLSKIQAVTEQNANAIKTVASNQALPNAAPQVSSSNDRTHEAIRETNDRLQALTKILTERELDAPPVGKVQDKLARHLEETSSQVQDLMAAQRETFDVVRELAMSITREKRICDHIVTPPPRKVGRKILGYVYDGSEAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M3D8R8</accession>
    <name>M3D8R8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_106629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762410.1">
        <property type="nucleotide sequence ID" value="XM_016900647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D8R8"/>
    <dbReference type="GeneID" id="27897784"/>
    <dbReference type="HOGENOM" id="CLU_1180857_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF14289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="235" mass="26417" checksum="B5D564F9CB87EFEE" modified="2013-05-01" version="1">MTGINKHGMAHTPPGSPATQSSEEFKLVAPARGKQRNRSLPGDGLTLWSLPRELRDQIYELVCLTGQQGVPSYPHLVCKQMAFETERIYSNPNFSEVMHANAWKPDWTPREIPSQPHLPLHGKHKKQKSVCFTIPTLRTPGYKGLLVDAWYFEEDPGHVDGSYVWVRARARDRTETRRPDFMLLGAPAKAVMAEALDRLDAIQSHLPRKALVVEKHVRGALEDIAGRVRSDSQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M3D9P9</accession>
    <name>M3D9P9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_132224</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762720.1">
        <property type="nucleotide sequence ID" value="XM_016902484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D9P9"/>
    <dbReference type="STRING" id="692275.M3D9P9"/>
    <dbReference type="GeneID" id="27899621"/>
    <dbReference type="eggNOG" id="ENOG502SNI4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_3_5_1"/>
    <dbReference type="OrthoDB" id="5022096at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF167">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="35"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="330"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="401"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="425"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF14599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="435" mass="47836" checksum="181DCA98F4E06EA6" modified="2013-05-01" version="1">MESPPDPEYCAESNATEILGVTGAMMAMALVTCGARFIVRATMMKSYGADDHIMMAALLCAIATFICFVGEVNHANAVGRHFPCITPSQHQLFAKWQYVHSLVVMWGVILVKISIALFLMRLVPPGRNWKVFLWATIVFLVCFMLACTGTLVFQCWPISAVWTFQFEHCFSNATFAAIGLTNTSINCATDFLLATLPVPVIIRLHVNKRTKMTLALILSVGYFACAAGIVKAVKQATFFDETDPLWHNSFNVWNMIELCVGITAASLPGLRPLFAKILASTKSVFSHSWGSNDRTVANNSSSSGSHHRHNNNDQRRGNFKFRAGISLLDMSNISGGGGGETSKSKSPPRPQRPSRSNRMDDDDDEENGLFQVDPKRYTVAVTAAARDPGDDGNWGGDDLESPARSDSQERLTRPTPAHTCIYKTTEVSQTSLLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M3D9W5</accession>
    <name>M3D9W5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="8">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_146906</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="8"/>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF14870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762991.1">
        <property type="nucleotide sequence ID" value="XM_016903953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D9W5"/>
    <dbReference type="STRING" id="692275.M3D9W5"/>
    <dbReference type="GeneID" id="27901090"/>
    <dbReference type="eggNOG" id="KOG0787">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023861_4_1_1"/>
    <dbReference type="OMA" id="WSYPPSA"/>
    <dbReference type="OrthoDB" id="3264224at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF20">
        <property type="entry name" value="[3-METHYL-2-OXOBUTANOATE DEHYDROGENASE [LIPOAMIDE]] KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="10">
        <location>
            <begin position="122"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="473"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="480"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="490"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF14870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="508" mass="55747" checksum="6043F856DF260F4B" modified="2013-05-01" version="1">MLCQRARIRHHGIFARCTSSTGRLRGLRQLQTATVTDGDIGRLAAKPLHPLTLADLCKNGRPPLSQEALLSNANFTLDILPSRLAHRIQSLRSLPYIVVANPHVSKIHQNYIHSLSTLLPYAERKLQSLEEEITFTEVMVNLVQTHSNTIAILARGFLEARKYISKEEITRFLDEHLRARIGTRLIAEQHIALHFSSQPHADLSDASPPPQDSTYIGVIDTHLKPADIIKDCEHMVGDICELKYGLRPTINIIGDPETTIAHIPMHLEYILTELLKNSFRATIEAGTEKEPIEITIAPAPAPAELTARMKSKHGVVHQAEQEVERAGGISNYDQGNVDYASNANKPALAMSENIRALDQATPGVTIRIRDRGGGISPENLAKLWEYGFTTFNEDEMMDKISGNGGDGTAMSPSLDSLSAGGPAGGSSLAGLGYGLPLGRAYAEYFGGGIAVQSLWGWGTDVYLSLRGVGRLQDGRKEATEQEEGGEEEEAQKKWKYDEGNRKDLGGRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>M3DA99</accession>
    <name>M3DA99_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fungal_trans-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_161286</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763136.1">
        <property type="nucleotide sequence ID" value="XM_016907927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DA99"/>
    <dbReference type="STRING" id="692275.M3DA99"/>
    <dbReference type="GeneID" id="27905064"/>
    <dbReference type="eggNOG" id="ENOG502S0WX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009353_1_0_1"/>
    <dbReference type="OMA" id="ITCLPPR"/>
    <dbReference type="OrthoDB" id="3266505at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF6">
        <property type="entry name" value="PROLINE UTILIZATION TRANS-ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF15015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="699" mass="78708" checksum="DA6772F0819C50AC" modified="2013-05-01" version="1">MCRIYSDSFHPLSSKPRPTRKRPKVPEQQRQRAAVACKSCRRLKEKCDGQVPCSRCSRYNRLCEPADAASRPASSSHNGPSKSHAERASPSHERVQHLEYIARHFLGDVTLTDDALSKIVAKLESESDGTHRKPTDDPETPTLEEERFSVQNVSANTTSGSSIWHYSGEFSHWNFSMRLKSYVEQQLGGEAVNQFQVLDYWRPHHLKSRDSSMKSILESLPGKDVALFLVSKFCQFAQQTTFFVEEGWVRERVNALYRKNIVLTADDACWLCSTLMVLAVGTQFAHMPQNTPTYGEDAIESVADAVGISFYQQAADLIPDIIAIASVDSVQAFLLLAHYALPLDAHGVAYTYLGLALRMAIQNGMHRKHLGNEFDAYTRDLRNRLWWSTYRLEKRVSILHGRPASISSNEVDADHPVDTISATESETDIRRLENSMTKITDWLGDMAFVIFMLRKSPPSLRHTYFERLLQIKGQYLEWWQSAHIPDINTMQQSRAVAHLHLSKHMNLVFVGRPFLLNRARLNAATARKLSGRAMLNERWSELAGEALRSAEQIVAIEQQMHATIGLAKASWVEFSACRAAVLVLLAQCLHESSQQTRDVLGKGMNLIRYMSSANASTRSEASLVTSLENAIRHLDAQRAGTFDMYEPFGDLDWSPFDASMFNETPIDFEALGMHHFDEAFSISNGSLGPAPRPEVPPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M3DAB6</accession>
    <name>M3DAB6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_155439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762935.1">
        <property type="nucleotide sequence ID" value="XM_016907618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DAB6"/>
    <dbReference type="GeneID" id="27904755"/>
    <dbReference type="HOGENOM" id="CLU_628771_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF14814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="436" mass="48254" checksum="CF27C1F878E8CE5B" modified="2013-05-01" version="1">MWSASSGRLGTVHVTLSESYFQDVSGRTSHNKNTPFTQEFDTAYPFETILAILIAIISRLHLPPELAGTRKLAPHPVRNAMASDDNFGPGKHFRNRAEYEAAWAEFDRARSFEDDDDEEDEDGGPSFIPRSDPNDPSRIFLRPAPRSPDALLRNLSLTDEQRRQQLQPPSIPTPAVVRPAPKHFRQIIPLPPRPPASVHPSQKHFREPIPLPPRPTAAGVPGQTPSNRSGRQQYFSHAIPIVAPPSGPRSNLPSAPALTIQTSLPPPPPPPPPPPQAPRTKRTKRSNNFMRLPREYPRPNPQQFGDNNTGALIPYTSQAIRHVPSHPSHHPLPPPNSLVQAPYSDRINPTAPANPVVQEEDALSSPEELRRRDEETFTSSSNNREAESFSALERQTDSSSSTYDTASEDVRGRRAGWGEILPGEESWAAKRGGRGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M3DAE7</accession>
    <name>M3DAE7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histone chaperone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_161329</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Forms a chaperone-bound H2A.Z-H2B complex that acts as a source for SWR1 complex-dependent H2A to H2A.Z histone replacement in chromatin.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Forms a heterotrimer with H2A.Z-H2B, stabilizing the association of the histone dimer. Also, with a lower affinity, forms a heterotrimer with H2A-H2B.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CHZ1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763191.1">
        <property type="nucleotide sequence ID" value="XM_016907930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DAE7"/>
    <dbReference type="STRING" id="692275.M3DAE7"/>
    <dbReference type="GeneID" id="27905067"/>
    <dbReference type="eggNOG" id="ENOG502SCUM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130004_1_0_1"/>
    <dbReference type="OMA" id="MEGVQDP"/>
    <dbReference type="OrthoDB" id="3650629at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019098">
        <property type="entry name" value="Histone_chaperone_domain_CHZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09649">
        <property type="entry name" value="CHZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01082">
        <property type="entry name" value="CHZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone chaperone" evidence="8">
        <location>
            <begin position="54"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="36"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF15070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="108" mass="11811" checksum="F323EB89F6439E9C" modified="2013-05-01" version="1">MSAEQPSNTEGKADVQMDTGSSAKGKGKAAEPNDAMSEDDSENSEEEAEGEPEEADEDNMEEIDPDNIVQSRTRGKNIDYAEAAKQMPEGDDDEEDDEDFQDDDAMED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M3DBD0</accession>
    <name>M3DBD0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_59669</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763280.1">
        <property type="nucleotide sequence ID" value="XM_016909500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DBD0"/>
    <dbReference type="STRING" id="692275.M3DBD0"/>
    <dbReference type="GeneID" id="27906637"/>
    <dbReference type="eggNOG" id="KOG2000">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006331_0_0_1"/>
    <dbReference type="OMA" id="DYCFHVG"/>
    <dbReference type="OrthoDB" id="775571at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF70">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="7">
        <location>
            <begin position="19"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="6">
        <location>
            <begin position="388"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF15159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="738" mass="81393" checksum="CD6A55DC91DCA52F" modified="2013-05-01" version="1">MDIGVLPHEFTLKALGSLALGRSSSLFEWDSSEGKFKITLEGATITGTSLLCSSSLVEEVAHVGSMTMRLRSFVDSSRASKTCPAAMALRSCVARVVDTVEERISGCLGAVKSPLQLLQLVAQPGNLLKLLITICDRTMTLRTDETIIAGLSDLVYELAESETRFCVILQTLLARVSMPWLEMLSADLGLRATGERQTLETAPGISADEHAFLDVNDDHLVRATKHAVAVLREQSPNHPLVTHDKTSAATRFADLSVDIARAHEVAKQYELQMTRTILGTSSIQAAPTATVNSSLDGTWFSDPFQGDHIAGLVTQMSLDPRSSDPGESDRLRHDAMHALTTEDEPTTLQALGRSVEYSPIANLRPLVRVQHKLVNGVLVRQLLRKHDLRLHLERQRSFQLLGNGTFVARLSRALFDKEIQSAERKRGVVPTADEMGLRVGATKDQRWPPASSELQLTLMGLLAEDTNHGASPQTDPTVRQSHLSFAIRELPEEEIERVLDPHSIHALDFLKIDYTTHAPLDAVITPSSLSQYDGVFRYLLKLLRLLHVTASFPRTVPGSRCESAPCSTLAFAQRARDFIVVLVGHVMSIGINAPWQTFNAALHSLEQDLSAEDERSEFGSRATIGVESLRQLHESCLDRIRTRLFLKRKQEKLRAGVEDVLISILQCATTMQSEGTALVRADDLQNFHAKLSHFLKLLADAVEKPPKTVSAVDAEDLDMVRILLARLDWNGYYTAQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M3DCL2</accession>
    <name>M3DCL2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ACB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_147569</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763896.1">
        <property type="nucleotide sequence ID" value="XM_016904386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DCL2"/>
    <dbReference type="STRING" id="692275.M3DCL2"/>
    <dbReference type="GeneID" id="27901523"/>
    <dbReference type="eggNOG" id="KOG0817">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043304_1_0_1"/>
    <dbReference type="OMA" id="WMRRKKD"/>
    <dbReference type="OrthoDB" id="346910at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF133">
        <property type="entry name" value="COA BINDING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12300)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="283"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="ACB" evidence="4">
        <location>
            <begin position="5"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="159"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="214"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="183"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF15775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="362" mass="40951" checksum="F8B181A2651169B6" modified="2013-05-01" version="1">MADSVDRVFGHALNTVNKIRPGSQKPPSSDRLALYGLYKQSMEGDVSRISDRPTASSSFSSSVAGCTPETLKKEQEKWDAWKANEGLGRTEAKRRYIETLIATMRLYASTTPEARELVEELEFVWDQIKNNSQHSSSEHSSPLQTIERRDYMHSGHSIKGLKMLAPQSEVDEDERGMLAQGNGEEEEAEDGEEEVEDFVDAPVSQIDDADLHHHAASESAGDVDSSPHNRFRARAPPPTSSASDNRWRKRIESSLIKLTTEVAALREQLETRRFLNYQRKHSWWGWVLRLSWWALQLFVADGIILWIVILYMRRKQDRRLETAIRVLLGDAVAQAQSAVRDAKMPTLLPNITTRGKVKSPKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M3DD24</accession>
    <name>M3DD24_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Histone deacetylase</fullName>
            <ecNumber evidence="3 11">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SEPMUDRAFT_60864</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the histone deacetylase family. HD type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="3 11"/>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763840.1">
        <property type="nucleotide sequence ID" value="XM_016909544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DD24"/>
    <dbReference type="STRING" id="692275.M3DD24"/>
    <dbReference type="GeneID" id="27906681"/>
    <dbReference type="eggNOG" id="KOG1343">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007727_4_0_1"/>
    <dbReference type="OMA" id="CFVSPAC"/>
    <dbReference type="OrthoDB" id="424012at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000791">
        <property type="term" value="C:euchromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070823">
        <property type="term" value="C:HDA1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990342">
        <property type="term" value="C:heterochromatin island"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031934">
        <property type="term" value="C:mating-type region heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005721">
        <property type="term" value="C:pericentric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033553">
        <property type="term" value="C:rDNA heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070824">
        <property type="term" value="C:SHREC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140720">
        <property type="term" value="C:subtelomeric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031078">
        <property type="term" value="F:histone H3K14 deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031508">
        <property type="term" value="P:pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000183">
        <property type="term" value="P:rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902794">
        <property type="term" value="P:siRNA-independent facultative heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000005">
        <property type="entry name" value="histone deacetylase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019154">
        <property type="entry name" value="Arb2-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017321">
        <property type="entry name" value="Hist_deAcase_II_yeast"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF5">
        <property type="entry name" value="HISTONE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09757">
        <property type="entry name" value="Arb2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037919">
        <property type="entry name" value="HDAC_II_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="13">
        <location>
            <begin position="122"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Arb2-like" evidence="14">
        <location>
            <begin position="495"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="42"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="769"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR037919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF09757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMF15719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="816" mass="90997" checksum="0FC73B9C55863CCB" modified="2013-05-01" version="1">MEQDEAQDMVMSDADVICSTENHSSLLTHSAGENVTGKQALGTFDGTGQLPRPHYLESTGKGKGKGNSHQSDARDHLLVARKDAPKPAKYANLPYSTLQTGLVYDVRMRFHVEAEPPEDDLHPEDPRRIHAIFEAFVNAGLAWREGESGPVNDHYMGRIDARMVTRDEVCLVHTLNHWHWVQSLSVLSTEELGNELQHPPHGNDSIYLSNSTPYCAALSAGGAIEACRAIILGKVKNVFAVIRPPGHHAEREDAKGFCFYDNVSIATKACQREFKDSCRKVFILDWDVHHGNGIQQANYDDPNVLYVSLHVHKRGNFYPEHSYRDNRVSYGDHLHCGEGAGLGKNVNIPWTKQGMGDADYLYAFQQVVMPIATEFDPDLVIIAAGFDAAEGDMLGGCKVTPAGYAHMTHMLMSLADGKMAVCLEGGYNLESIARSATAVARTLMGEPPDRLTQTVASVSGIDDVKLVARQQSKFWTSLYPKDISERLNGPLHGERMHNIVRGWQAKTLWEEYRMTPLFVHREQLAKEFEDQVLATPNYGTARALLIVLHDPPEVLSSPDPRTGKIELHNTWLTDIVKTYVDEACKAGFGVIDVNLPRYITDFESDTQEHQSNDDVDFRIKEAKQLLKYLWDNYVTLNESTHVYLMGTNTGHGAIIGFLKDSQETVLREYNDREEHHKTLKAITFVEDVSLMSCKSLVGGDDDLPNWYYRNSLVLVAHEHAYFASDFARKPKRRFGRVIRSEKNTITDMLLEHKGDVFEVLLEDADAWREDKPKHGDDEVAPLAPLPPPAKTATALALPSVTDANGAATVNGNRGPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDX3</accession>
    <name>N1QDX3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glycerol kinase</fullName>
            <ecNumber evidence="3">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP:glycerol 3-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SEPMUDRAFT_150523</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SO2202</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="3"/>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758521.1">
        <property type="nucleotide sequence ID" value="XM_016906235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QDX3"/>
    <dbReference type="STRING" id="692275.N1QDX3"/>
    <dbReference type="GeneID" id="27903372"/>
    <dbReference type="eggNOG" id="KOG2517">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009281_2_3_1"/>
    <dbReference type="OMA" id="FMLMNIG"/>
    <dbReference type="OrthoDB" id="5422795at2759"/>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07792">
        <property type="entry name" value="ASKHA_NBD_FGGY_GK1-3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000086">
        <property type="entry name" value="Glycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000085">
        <property type="entry name" value="Glycerol kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042018">
        <property type="entry name" value="GK1-3_metazoan-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005999">
        <property type="entry name" value="Glycerol_kin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01311">
        <property type="entry name" value="glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000756">
        <property type="entry name" value="PRK00047.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF69">
        <property type="entry name" value="GLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00933">
        <property type="entry name" value="FGGY_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 10 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="12">
        <location>
            <begin position="66"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="13">
        <location>
            <begin position="331"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMF10400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="581" mass="63059" checksum="E7CAD7E89A838565" modified="2013-06-26" version="1">MPSLEDCVQALPTHTPDDVASVMKGADAGTVPAQKDPNGGGQPKAERPGLPRFTTSKENVLAQFFIGAIDQGTTSTRFIIFDGTGSPVASHQHEFTQHYPQSGWHEHDPAELIASVENCMKRATATFTDLGHNISDIRAVGITNQRETTLVWDVETGEALHNAIAWPDTRTKGLVRELQKKEEELGLKFSELTGMPISTYPSAVKLVWLLRHVPKVREAYDAGRLAFGTVDTWLLYNLNGKNKDYFVTDSTNASRTMFMNLHTVKYDPKLLEFFDIDIGKLNLPRIVPSSDAQAYGRIASGPLAGMKIAGCLGDQSAALVGQQGFTPGSAKNTYGTGCFLLYNVGETPVVSTHGLLATIAYDFGGKRKPVYALEGSVAVAGSGVKFLMNNMGFITHSHKISDLAATVEDNGGCVFVTAFSGLFAPYWIDDAKGTIFGITQHTQRGHIARATLEATCFQTRAILDAMEKDSGHKLSALAVDGGMSNSNLCMQAQANIIGISVDRPAMRETTALGAAIAAGFAVDIWKEFEELKAINQKDRVIFSPDCTPEVSKKMFKKWSRAVEMSRGWLDPDEAGGEFEEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1QEU8</accession>
    <name>N1QEU8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_133692</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759804.1">
        <property type="nucleotide sequence ID" value="XM_016902578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QEU8"/>
    <dbReference type="STRING" id="692275.N1QEU8"/>
    <dbReference type="GeneID" id="27899715"/>
    <dbReference type="eggNOG" id="KOG2565">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019414_5_0_1"/>
    <dbReference type="OMA" id="TTYSMHV"/>
    <dbReference type="OrthoDB" id="7130006at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF71">
        <property type="entry name" value="EPOXIDE HYDROLASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="4">
        <location>
            <begin position="22"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="230"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="468"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="238"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="293"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF11683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="488" mass="52996" checksum="2188BB405D128B75" modified="2013-06-26" version="1">MASITSSSSGRSSSAAANVVLPYRMHVSQRYLDLTRKKLDLTRLPREPRSRQAAPWGFGVAKTDLEPIIDHWTEEYDWRTREAHYNDTLPQYRVVIQGIRLHYVHKRSMSPNAMPIIFCHGFPESFIGISHMMEGLTNPLSTPTTGSENLPSFHVVVPSIPGFGFSDMVAEEGNNIASTAELFDALMKSLGYPRYIATGSGWGLNICRLMALTHGESCMAIHTANPDLPDPRYAHMQQPLSMPASPTSYSPPQTPGAQPVTLERPQTVAYALCDSPTGLMAHVYDAISPSCPGENNNNNSPISTKSSSGGGGGDEDFHDTPCWTPTTLIDWCMLYWLPGPEVALRWLMNSAPMIPKLWRSHCPVPLAISHFSDPHNTSGGTQWAESYHHIALISRRSAVVVGGGGGGSRGARGTGNASSQVRFAAWERPAEMVADIRALACYIAPVFWGGFSPLPSPGARQQQQIVVPSNMPPPPTTMGSMGRVGGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1QEW2</accession>
    <name>N1QEW2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MINDY deubiquitinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_149617</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759829.1">
        <property type="nucleotide sequence ID" value="XM_016905666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QEW2"/>
    <dbReference type="STRING" id="692275.N1QEW2"/>
    <dbReference type="GeneID" id="27902803"/>
    <dbReference type="eggNOG" id="KOG2427">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007080_1_0_1"/>
    <dbReference type="OMA" id="NVNPMFV"/>
    <dbReference type="OrthoDB" id="10261212at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016807">
        <property type="term" value="F:cysteine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990380">
        <property type="term" value="F:K48-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007518">
        <property type="entry name" value="MINDY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033979">
        <property type="entry name" value="MINDY_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18063">
        <property type="entry name" value="NF-E2 INDUCIBLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18063:SF6">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04424">
        <property type="entry name" value="MINDY_DUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MINDY deubiquitinase" evidence="2">
        <location>
            <begin position="334"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="642"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="725"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="733"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="770"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="827"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="900"/>
            <end position="909"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF11708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="909" mass="99626" checksum="8A5407673BC1492C" modified="2013-06-26" version="1">MVTRKPVGPRVDTATATAPNGSAPYPTTPTKNEDVYSNDLSTSPAFNLIDMNAAREKRRRDSDVSSHGTWDSDDTDRDRESPEGFVEVPQPLNVTPGKQDSKKHGRNESELPSILRPGPVNGAVGGKNEDRRNEDEKSNNPYHKQNGLVNNNDSQKSTESSQPIWEQPRHAAPPLPSQAPPPPPVELPTLTTPAEELAHLSLGDKPVVQSETTLPVTNPWAEGKTPSPPPPPKEALPAVSTEHGNIPIALPSPKSPGYFPTPSAHPEGSSQPPQYAPPPGPPPSASGPLIDHAEPPASRPLPSISVDRPIASSSSAPHTVPETPRTQERKRNEHYQIKHINWQDREKMRSSPILTQNENGPCPLLALVNALSLSTPLDMDTPLVETLRTREQVSLGLLLDAVFDELMSGRRGDTAHNLPDVSELYAFLLALHTGMNVNPRFITPAQTPRGSYDGHPQAMNGVHPLDRAQSKPGSFEETREMRLYSTFNIPLIHGWTAPKDTPDYAAFERSAKTYEDAQNIQFAEAELKHKQQSSEGLSTQEQEMLQDITTINGFLSNWPTQLTDHGLESISQSLHSGQIAILFRNDHFSTLYKEPRHGALMTLVTDQGYGSHAEIVWESLVDVNGAASEYFSGDFRSVSHGASSNLNQGNSGGGNEGWETAQSRNRYHRPQAQATDTEVPPPLPGPRPASSVSTQAHTEDSLDVTSQTLRTASEQEDHDLALALQLQEEEEDQQRQDEERRRRERELSERYLSSETNERPPQIPPRRNNAHTSPQSSSGNIPVGATSSRPQGRPAVNRPTDSTDDPDAPPTYEQSSHDRPYRPAGATAQSAQGNPLQTLDQLQRQSAYAQQSPMGANGTPGSYPRRDSGRRRRRSQAHQGQTPPYSPQLPERVPNAATVKDADERCVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFP6</accession>
    <name>N1QFP6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TPR-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_149849</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760188.1">
        <property type="nucleotide sequence ID" value="XM_016905810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QFP6"/>
    <dbReference type="STRING" id="692275.N1QFP6"/>
    <dbReference type="GeneID" id="27902947"/>
    <dbReference type="eggNOG" id="KOG2002">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003008_0_1_1"/>
    <dbReference type="OMA" id="EHWLTIA"/>
    <dbReference type="OrthoDB" id="343875at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031101">
        <property type="entry name" value="Ctr9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14027">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN CTR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14027:SF2">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN CTR9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="223"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="608"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="951"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="957"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1039"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1110"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1154"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1187"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1197"/>
            <end position="1211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF12067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1218" mass="136626" checksum="4E542FDEEE3B87F0" modified="2013-06-26" version="1">MAAVPNGYTNGVNGHAANTAVAAKSFERFADVPTVIDIPVRGDDGDEAVNVDLSEALDDVGELCDLLETECVAKNYWITIALAYVKQKRANMAVDILKRGLEALRAGRDEDKLSLLTCMCWVYLWQCRRAPRVKPTQPKEGQTDERLKENWLALATSTLNDASRISPSYPPLFLARGTLLLLKASLQPQKFGPGGEHSDRADTLKQASKCFDDAYRTSGNKNVLAVMGKAKANFSMGKFDQAYVLYQQALERAPDMVDPDPRIGIGACLWQLGHKENAREAWERSLELNESSTIANILLGLYHLDQSSHYNSNDPAFAPIYGKAMTTYTQTAFKLDAMHALTCATFGGYFLLRRAWVNVDRLARRAIEHTDVNASASDGWYLLARKEHYEGDLQKAQDYYNKADLARGGDERGYLPAKFGAAQLKTLMNDYDGAKFRLEKMVSTNKSVEAMTLLGILHAEDVFAKQVTGLKEETADSRKKAIALLESVRVAWRDSKKKISPDSAVLLNLARLYEQEQPEKALACLQHVEQLELDELDDEDLPEGMEDETAILAAKREMLSPQLLNNIGCFHFQAERLSQARENFQAALRSSVSISNKDASVDTDALVSTISYNLGRVYEAEGIEDEAEKIYKSLLDRHPDYVDANIRMAYLALRSDPVKGGEAIKQLVDADPGNLEARALHGWYLNRTKKRTLALNEDQEQKHYKHTLMTYDKHDIYSLTGMGNLNLVIAREMPRDTDQHKDRRSKTYSRAMEFFDKVLTLDPKNAFAAQGVGIGMVEERKDTAAAIHIFSKVRESVKDASVHINLGHVFCELKQFSRSIENYELALVKSREKDPQIMACLGRAWLMRGRTEKNLEHYKMSLDYSQQALAHSPENINFKFNVAFVQIQIAQQMITQPEANKTLVDVEAANKGLDEAIESFIEIAKGPSPPFPRHDIEQRANMGRNTMKRQLATATERQAEYERKNANRLEEARRRREEEIRKRENEKRAAQEKAEEEKRKLREERERIQEEDRKIIEKRLNDERIAEEAQYTTDEDGTRRKREKKPKEKRQKRKKKGEDSDTDADVAADGTGDEGGRSRHRSRATSATGSDGEGPRKKKKRRLERKGQAVKSNSKYKSAETVQDSDDDDDAGLAAPGSTQPKSDDPESPGVDAGGDEDNVADGGDEEDDDPSAARSTQRRKPARVLDDEDEDEELPDAASALANGNGNNGAVTDASED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFV2</accession>
    <name>N1QFV2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_119167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758753.1">
        <property type="nucleotide sequence ID" value="XM_016901482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QFV2"/>
    <dbReference type="GeneID" id="27898619"/>
    <dbReference type="HOGENOM" id="CLU_652407_0_0_1"/>
    <dbReference type="OrthoDB" id="5471373at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF10632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="421" mass="46615" checksum="F680208B923E9583" modified="2013-06-26" version="1">MADSPEPSLSTTTSIAKLRTWQDWNVWITHIENEAEALQIWDDINPGSYFQYNGDTKFKSKHRTTVASISTAAATESSSSSNRSSSSRLSKPCLCSRNHMWKECYYLNAEYPRPEAWKLRDDTKKKIEKRFKEDKNLKERVDKAIQAYNAAQGQGSKDKEAKNKLGIAAELEDTAAAATLESTPEASVGLIGYTRLYNAVILDSGANMHIINESIRARIVRSELPTSSDIVISGDKRYQPEAIVDATINLDIGNRVTRKLTLLKARLIPGFFTSLVLLQILNKKGIYHNTRNWPDKLITGQAYKEPRLWACLTPEHSDDRHGYWIIERLPATRSVAGTTGIPVLSRTPGIEEVKSVCTPHSENAGKSTLPASTSPAGSVAAAQSSYKPLLPLTATANQWHQLLGYLSVRAIENLEPASKGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFX5</accession>
    <name>N1QFX5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Rheb small monomeric GTPase RhbA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_149951</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endomembrane system</location>
            <topology evidence="11">Lipid-anchor</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the small GTPase superfamily. Rheb family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760344.1">
        <property type="nucleotide sequence ID" value="XM_016905872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QFX5"/>
    <dbReference type="STRING" id="692275.N1QFX5"/>
    <dbReference type="GeneID" id="27903009"/>
    <dbReference type="eggNOG" id="KOG0395">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_9_8_1"/>
    <dbReference type="OMA" id="SARHNEN"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04137">
        <property type="entry name" value="RheB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000273">
        <property type="entry name" value="GTP-binding protein Rheb homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF12223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="188" mass="20791" checksum="673B6AA1E78127D1" modified="2013-06-26" version="1">MGPQQKQRKMAIVGSRSVGKSSLTVQYVDGHFVDSYYPTIENTFSKVIKHRNQEFGVEIIDTAGQDEYTILNSKHFIGIHGYMIVYSVASKQSFEMVRIIRDKILNHLGAEAVPIMIVANKSDLRPEQRQVSTADGKSLAEELGCGFVEASARYNENVGKAFEGMIAEIEKGQEAGQPKEGNSKCAVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1QG31</accession>
    <name>N1QG31_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_110977</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757629.1">
        <property type="nucleotide sequence ID" value="XM_016900888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QG31"/>
    <dbReference type="STRING" id="692275.N1QG31"/>
    <dbReference type="GeneID" id="27898025"/>
    <dbReference type="eggNOG" id="ENOG502SKHW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043694_1_0_1"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="2">
        <location>
            <begin position="253"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF09508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="450" mass="49605" checksum="E1DD312B745DDC88" modified="2013-06-26" version="1">MPSTPPPSEQITQIFRIISEALSSPFSSSTDNDGEEEEENFLPHETWKYHGLTGLLASATAADISRYLAETTETTTTATTTGGGGGSSKREVPQNVFERYPTVGEFRRWIFGVLGEEDGENKGEGKRGVENEQEPENPWEGIPKPKVPLSVVLQGKVSTASKIVFLFPDGSGAGTAYGSLPDLGGGETEEDEERGGGGKGGICIIGLNSPFLRQAQNFTCSIERMTRLWYDEVRKLQAQSHQTPTPTTKEKEKQKQKIPYILGGWSAGGYYSYEMAKLLTGAGEIVSTLILIDSPCRLLYEALPVQVVEELTKKGLMGASSSSSSSSQQKKAAPEWLVQHFTSTVLSVQRYQPVAMQESRVPENVYCIWVEEGLVETSVEESGLDVDVNVRVTRFLLEGRREKKLESEGWERLLPGAEFGFEYMTGNHFQITQVPHSHSLGRILRKILKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1QG44</accession>
    <name>N1QG44_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Blue (type 1) copper domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_118198</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016901409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QG44"/>
    <dbReference type="STRING" id="692275.N1QG44"/>
    <dbReference type="GeneID" id="27898546"/>
    <dbReference type="eggNOG" id="ENOG502S40X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053381_1_2_1"/>
    <dbReference type="OMA" id="CKAPTHC"/>
    <dbReference type="OrthoDB" id="2331100at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000923">
        <property type="entry name" value="BlueCu_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052953">
        <property type="entry name" value="Ser-rich/MCO-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883:SF15">
        <property type="entry name" value="EXTRACELLULAR SERINE-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883">
        <property type="entry name" value="SERINE-RICH PROTEIN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00127">
        <property type="entry name" value="Copper-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0186">Copper</keyword>
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    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110777" description="Blue (type 1) copper domain-containing protein" evidence="5">
        <location>
            <begin position="18"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Blue (type 1) copper" evidence="6">
        <location>
            <begin position="24"/>
            <end position="113"/>
        </location>
    </feature>
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        <location>
            <begin position="125"/>
            <end position="196"/>
        </location>
    </feature>
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        <location>
            <begin position="154"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF12262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="220" mass="22327" checksum="E965F352B3A90D05" modified="2013-06-26" version="1">MQSRLTLLLLLGSSAYAQTVHEVVATDGVEFEPNSLSDVAAGDMIKVTFSKVNHHDIVSGSWASPCEFNSAVGLNSGVYSNGEVFEFTVNSTDPQIFFCAVGPHCQLGMSLAVNPSGDETIEAYQTASKGKEATGPTSEGPVGGTLVGTMTTASSNDDPANSTTTTTNTTESTNTTESSNTTNTTSSPTPTASSSGAAAGFGASVAMIGALVVGAMAFVM</sequence>
</entry>
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        </submittedName>
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        <name evidence="3" type="ORF">SEPMUDRAFT_150005</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="SMR" id="N1QG83"/>
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    <dbReference type="eggNOG" id="KOG3456">
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    </dbReference>
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    <dbReference type="OMA" id="SMQAPNR"/>
    <dbReference type="OrthoDB" id="307899at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial"/>
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    </dbReference>
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        <property type="entry name" value="q5lls5 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Znf_CHCC"/>
    </dbReference>
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        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 6, MITOCHONDRIAL"/>
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    </dbReference>
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        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 13 KD-A SUBUNIT"/>
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    </dbReference>
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        <property type="entry name" value="zf-CHCC"/>
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    </dbReference>
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            <begin position="131"/>
            <end position="166"/>
        </location>
    </feature>
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        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF12312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="223" mass="24459" checksum="DA2AFFB0E0A8B43E" modified="2013-06-26" version="1">MLQRGTQRLFPAIGRRAIGARSYSSFTTDNTIPANSPQQPTRRSPVSSTNALPTVAHGAQDEALVEQAEEAEHKRVMQAPNRATVWSRSQKPRAEAMVGPRFEQTIMEDQPRPLAAIELIHKQPVRWTKERVVSCDGGGGPLGHPRIFINVDKPQICMCTYCGLPFAHEHHRKHLQSLPSTTYPLEPTGDAAQIPAADMNSGNARTGATTPYQTATGEAYGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>N1QG89</accession>
    <name>N1QG89_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_118269</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">Poplar stem canker fungus</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF12338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="90" mass="9826" checksum="D118F568235A695B" modified="2013-06-26" version="1">MDEADGEKVEAEEEDEQEEGRGGQEKRWSESERTGTGTGTGTETGTRKRATGLLLHGDGRESEKGEDEDENENENEGVGVTQAQRLQEAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1QG98</accession>
    <name>N1QG98_SPHMS</name>
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        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_72390</name>
    </gene>
    <organism evidence="3 4">
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        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757694.1">
        <property type="nucleotide sequence ID" value="XM_016909990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QG98"/>
    <dbReference type="STRING" id="692275.N1QG98"/>
    <dbReference type="GeneID" id="27907127"/>
    <dbReference type="eggNOG" id="KOG0274">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009186_0_0_1"/>
    <dbReference type="OMA" id="GPHPTYE"/>
    <dbReference type="OrthoDB" id="2095648at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027040">
        <property type="entry name" value="PSMD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223:SF2">
        <property type="entry name" value="F-BOX AND WD DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G11400)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="125"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="635"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1001"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1054"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1112"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="636"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1005"/>
            <end position="1018"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF09573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1140" mass="122994" checksum="BD376F76D52BAC35" modified="2013-06-26" version="1">MLPEPTPLATATIQSSIEQNSPTSQHGFLHDDQPAVALSPANAETTSGEEQSALDAALAASLQERAEDGAVSASSVKRLSARATPSPPARNRVLEYEQASTPPVRKREGPAFEVIKKPRNPGDKSSPIQDLPNEVLTHALARLAPNDLACVSLVSKRFHSLVTGPHAWRTAFSHFFPGSDSINCDLLENDSDSQAVVKSERRAFTRLTPLASWRSEYIMRTRLLRSLSRGKPMQAANSHATRTQTVAPTVMYNSQLYTTINHIHATFGSVTNKKLPRFAHGADEFGTATSSDPNAAKVDSWGLTDPQIFPQFADRFPGDAQYGLGPGEVVGLPNSMDVSQPYGMIVGEGAPGGMVYYRSTEEMRGRFLTPTSAVTAHELGIPRIASNNEAVTAVWIAKSAAVPSLTDGLIGLFSGSSLGVLTAYSLGASSSGSTRNQRYSRGETTARWVLSPGVPIIQIAVDNEHTLNRMAQNRIWVVVLNALGEVFYLTKSPKRPHLDRGSRLDDEAIERMAWQTGRTVYWNTVEPSRRIAKVDPYADGSVDGSYSPRSSWNGMCLSTGQISAETQEIEAFMRRKPKDFQRLCAGWDMRRVLEVDFAGDDGNNAGENIVVFGCAREEGSIASVRRYSRLRVQDRAASQTVPPPNLTSAITEASTPPSMFGGSPSPITNPATGLSLGLLSTSLAHDEFDGATTPRPMAEEWRTTDYSMGGIKHVEILATTIDRSTFATQTASEDPLLGFSGRSAASSPSYTPMIAPDSAVSSSDVPGQRARMFAIGTKLGTVIVWDMRASIARSVDTTNTIDPSRIIHTDSPEISCLALSSLCLVHGGNDGLVQAWDVLASEVQPIRTLNSKFSSRARRRLLQAQASPQGVGINLFAAGAIYLDPDPTILRGIVSLGTHLLYWAYSSSAADQYKSNKRRLRRSERGSNAATERFSGAMRSNLNNYIESEKFELHREKEQRNKESQRIAGRFGTDLLDGSEEEMIAYAAMLSQEAFERDHARRASDTSVSNSIAASSVDRSVAATPAQSPSPHRPTPKTEDELDADIAEAIRQSLATSPPAGYEIPIRHAKPKNKRAPSAQESPKPSPALAGSSQAAELSDLDFAIQLSLAEEQSKQAAGDEDAFPGLPGASGKGKGKKVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1QH88</accession>
    <name>N1QH88_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_145777</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764671.1">
        <property type="nucleotide sequence ID" value="XM_016903261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QH88"/>
    <dbReference type="STRING" id="692275.N1QH88"/>
    <dbReference type="GeneID" id="27900398"/>
    <dbReference type="eggNOG" id="KOG0061">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_57_7_1"/>
    <dbReference type="OMA" id="MCVNGFM"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03213">
        <property type="entry name" value="ABCG_EPDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001305">
        <property type="entry name" value="ABCG transporter ABC superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052215">
        <property type="entry name" value="Plant_ABCG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48042">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48042:SF11">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="395"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="439"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="477"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="502"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="603"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="25"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF16550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="627" mass="69149" checksum="7A6EE8E2C2754836" modified="2013-06-26" version="1">MSDIEKMIGGDYAQLTNTNIRSFGWKGVTVTVKDRQSQQPKTILSDIHGIVKAGELLALMGPSGSGKSTLLNVLAHRTHSLAANVKAAIYINGSAANPKTFRRISAYVEQEDALVGSLTVRETLNFAARLSLPSTVSKLERIQRIEALLTAFGLKGQANNLIGTPIRKGISGGQKRRVSVAAQLITSPKLLFLDEPTSGLDSAASFEVISFVKDIAKKHNLIVIASIHQPSTSTFAMFDKLLLLSQGGTAYSGPVSEVQPYFDACGFPIPLYMNPAEFIIDFVNTDFARDRSEVDQQLNMVHSSWHKSRLATATVTELTDEMARNSMDTDVTADTKEEAAGKFAIPMALVHRSFIKSYRDIIAYGIRIAMYMGLAVMMGTVWLRLNPDQGNIQSFINAIFFGGAFMSFMAVAYIPAFLEDRALFIKERANGLYGPSSFLLANFITGIPYLFLISMLFSIVAYWLSNFRPTAEAFFTWVMWLFLDLIAAESLVVLISSLIPIFVVALAGTAFANGLWMCTGGFLVPPQTLNPFWRYVFHYIDYQSYVFQGMMVNEFGKRNFTCGTNSQGECSCLYETELAHQCLIAGTGVLKNYGYKTGETGKWVGIMIGIICGYRLLGWLTLSLRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1QHZ4</accession>
    <name>N1QHZ4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_166256</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="27905351"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OMA" id="FWVLEAV"/>
    <dbReference type="OrthoDB" id="4139357at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
    </dbReference>
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        <property type="entry name" value="MFS_Str1/Tri12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF109">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="72"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="306"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="535"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="43"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF09599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="569" mass="61832" checksum="E1660B9E8E9A7AB2" modified="2013-06-26" version="1">MDQEKRQDVEKLEPVDSHSDAVSNAGISHDEGENKLTFAFFMTMLGLAMAFVVAEVTPLFFATCFTVIAFDLGAIEQVVWILVAPYIATGAVAPFVGSLSDLMGRKGCIQTSLVLAIVAFILQGAAPNFGCFLVGATMAGAAIGIQILTVVAAASELVPVSKRGATIGYIVMGFMPFAPSSLYGQLIAEHNWRYIFVLLGTWSFLSLVVLQIWYKPPPRPAMLEGVSTMQLLKRIDYGGSALSILSVVLFLIGINWGGGDYTWDSPQVICMLVFGIFTFILFVLYEKFVAPYPMFPARLIQSKRHFFSVSMLCFTSGVNYIPLTVFWTIMTYSVYGSSFMEAGVNLLPLGFCIAGGAIISAILITVFKRHIQWVLLFFCIMQVCGISCMSLYDPNNINTVWAPMILGLIGVGAVLLPSQVVFSVISPDDLIGTSVALSLVIRMMGQVIGKSMFYNIFRQQVKAKAAGFVGLPAVLAGFVTPEGLPDIPGITKLVTTMTAGPLSHYLPLFPQINTPEELASIVTAGQAMYSECFQLLFYVSIPFGVLAILSCFGLWGIDKYMTKRVAVHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1QHZ6</accession>
    <name>N1QHZ6_SPHMS</name>
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        <submittedName>
            <fullName evidence="4">Cell wall integrity signaling protein Lsp1/Pil1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_145962</name>
    </gene>
    <organism evidence="4 5">
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        <name type="synonym">Septoria musiva</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016903370.1"/>
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    <dbReference type="STRING" id="692275.N1QHZ6"/>
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    <dbReference type="eggNOG" id="ENOG502QQ1T">
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    <dbReference type="OMA" id="NRWLGKG"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036286">
        <property type="term" value="C:eisosome filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0070941">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Sphingolipid long chain base-responsive pil1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="PIL1/LSP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962">
        <property type="entry name" value="SPHINGOLIPID LONG CHAIN BASE-RESPONSIVE PROTEIN PIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962:SF1">
        <property type="entry name" value="SPHINGOLIPID LONG CHAIN BASE-RESPONSIVE PROTEIN PIL1"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF13805">
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <end position="195"/>
        </location>
    </feature>
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    </feature>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF16815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="333" mass="37386" checksum="0A7CF53C9DACCE32" modified="2013-06-26" version="1">MHRTYSMRQSRAPTASQIQNPPPAASSTKGGRLFGRANIGHTFRKSVHPGAFGPDLAKKLSQLVKMEKNVMRSMELVGRERMEVAQQLSIWGEGCDDDVSDVTDKLGVLIYEIGELEDQFVDRYDQYRVTIKSIRNIEASVQPSRDRKQKITDQIAQLKYKEPNSPKIVVLEQELVRAEAESLVAEAQLSNITREKLKAAFTYQFDALREHSEKIAIIAGFGKHLLELVDDTPVTPGETRNAYDGYEASKAIIQDCEDALTNWVEQNAKVTSSLSTRARTLSQRRRNKTSGHDLAEQDQDRESGLWVSAEQHGAGQDFDDEDSVRGREEHVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>N1QI73</accession>
    <name>N1QI73_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_156980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016907711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QI73"/>
    <dbReference type="GeneID" id="27904848"/>
    <dbReference type="HOGENOM" id="CLU_1422238_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF12144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="191" mass="21378" checksum="C7DA23B23E95AB8D" modified="2013-06-26" version="1">MPEDPEGFLPNRRPETCQKSGRDCSNVVVRMRQWVSEGEKEEVQEEEEEEEEEGDAAGGGDGSRRKEKAEEEEEEEEVEEPLIRSSLISSSMAIPNNNSVSIIPVFLEGKVPISDNAVPLNNSSFYSLSSNSPRPRPPLSLAHKRHTHDVISQRAGQVTVSRFGLVLDSELVNIGTKTITCIHLYSRYRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1QIG2</accession>
    <name>N1QIG2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AFG1_ATPase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_150901</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AFG1 ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759094.1">
        <property type="nucleotide sequence ID" value="XM_016906465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QIG2"/>
    <dbReference type="STRING" id="692275.N1QIG2"/>
    <dbReference type="GeneID" id="27903602"/>
    <dbReference type="eggNOG" id="KOG2383">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008681_1_1_1"/>
    <dbReference type="OMA" id="ARRFINM"/>
    <dbReference type="OrthoDB" id="548867at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141164">
        <property type="term" value="P:mitochondrial protein quality control"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005654">
        <property type="entry name" value="ATPase_AFG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040713">
        <property type="entry name" value="ZapE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169:SF6">
        <property type="entry name" value="AFG1-LIKE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169">
        <property type="entry name" value="ATPASE N2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03969">
        <property type="entry name" value="AFG1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="528"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF10973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="557" mass="63250" checksum="4C11921FB3C4262F" modified="2013-06-26" version="1">MTTPEASRVLRSLVRATRPHVTRQQRRTICVECLAKERTTTSLHRPALPLAVHQRKSRRRMSTQVEIRQQGITGTGPIAEYDARVQSGRLRDDEHQRMLIQSLQDLHDVLVHYVPPPVVKPTIESLQPKKKAGLFGSLFGGVGDSQLVMRARPDLPKGIYMYGDVGSGKTMMMDLFYDTLPDNITHKTRIHFHNFMQDVHKQLHKMKMQHGQYIDCIPFVAAEIAEHASVLCFDEFQCTDVADAMILRRLIESLMAHGTVMVTTSNRHPTELYKNGIQRESFVPCINLLLDQLRVLNLDSTTDYRKIPRPPSGVYHHPLDASSARHASYWFKFFGDFENDPPHADTQHVWGRNIDVPKASGRACWFTFNELIGSATGAADYLELVKHYDAFVVTDVPGMNYRSRDLARRFITFLDAVYESRAKLVLTTAVPLTQLFMSRTEIDNMIDEAANTVNADKRVQAAAKKKNEQQSQAGSDVDDTMRMMMDDLGMNMDSMKKSSFFTGDEEAFAFARALSRLTEMGSQEWVERGLGMSSTGSGQKDVEDWKKVRSSWRQDSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1QIL9</accession>
    <name>N1QIL9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cora-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_153101</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765151.1">
        <property type="nucleotide sequence ID" value="XM_016907499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QIL9"/>
    <dbReference type="STRING" id="692275.N1QIL9"/>
    <dbReference type="GeneID" id="27904636"/>
    <dbReference type="eggNOG" id="ENOG502SFSA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_550007_0_0_1"/>
    <dbReference type="OMA" id="WQNIIGE"/>
    <dbReference type="OrthoDB" id="3231000at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015087">
        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494:SF1">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="394"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="454"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="325"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="460"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF17030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="496" mass="57770" checksum="7DD29415653920DA" modified="2013-06-26" version="1">MDAFCGTTWEGGESGTYYCFPVAVPELLRPRPALDGDSRVPIACRVGHRRSKIKYEEVALHGPADAASFSRVVHDQVRLHPHDPLIIAVNGYQPWLGQVLHTCIEDHWSDIADLDRAVQYAHTMQFPEKASQRGRWVPWTFIIDQMNVPHVYYWSVNLEPPMMHDNDLPNMADFRLRTGVWFCAKGACKLDRNISVTIVFTKPSPVSERIVTKLLFEYLWRDNDFDQPREDEEGICWTFSRLYYLCSDWQNIIGEVLARLDEAEINSHGRHLPVKARTRRMHREVDRIYEMKEYLHFHTRSFKKLQRLQIEVPPEQRKDPLWNDMDDAVEDLDQFESTLDGLKERFNNLIELEFNITNAMQSDNSAFLSGVATLFIPLSLVASIFGFTTITWPVIWFVYIAVPIFVVSVIFTAVFPALRKYIQKLAEPVQRPMALQPDQFTMLAEEYPDVVTVPRDRQGRSRHQTPLRQHSLARKPSRTQIRAWSRLGDSEEKDYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-12-14" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>N1QIU1</accession>
    <name>N1QIU1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_119052</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758625.1">
        <property type="nucleotide sequence ID" value="XM_016901475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QIU1"/>
    <dbReference type="GeneID" id="27898612"/>
    <dbReference type="HOGENOM" id="CLU_1994041_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF10504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="125" mass="14071" checksum="ADC0720157F1A0AD" modified="2013-06-26" version="1">MPPHSLATMVRPTAAFQYTASREAKDCQADGTFPIDNSLDSHFSSTHETDCIDLQGEHCTEFLPSVSTEGEPRFCRRRGRCLERAGSSKVKDHLKDVVKEQRLLPRVSENDRGTPLTHDGSIWDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1QIX0</accession>
    <name>N1QIX0_SPHMS</name>
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        <recommendedName>
            <fullName evidence="1">ceramidase</fullName>
            <ecNumber evidence="1">3.5.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_156711</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.23" evidence="1"/>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759886.1">
        <property type="nucleotide sequence ID" value="XM_016907691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QIX0"/>
    <dbReference type="STRING" id="692275.N1QIX0"/>
    <dbReference type="GeneID" id="27904828"/>
    <dbReference type="eggNOG" id="ENOG502REHN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_300555_0_0_1"/>
    <dbReference type="OrthoDB" id="5273684at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017040">
        <property type="term" value="F:N-acylsphingosine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029130">
        <property type="entry name" value="Acid_ceramidase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28583">
        <property type="entry name" value="ACID AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28583:SF1">
        <property type="entry name" value="ACID CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15508">
        <property type="entry name" value="NAAA-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acid ceramidase N-terminal" evidence="3">
        <location>
            <begin position="60"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="348"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="635"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="716"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="811"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="862"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="355"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="644"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="736"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="768"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="780"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="811"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="871"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="891"/>
            <end position="903"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF11765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="996" mass="109972" checksum="DCAF61D0C692A95F" modified="2013-06-26" version="1">MSPATRSQTLREATAASTDLPQHNLASPQHLNDVIQRRSTTVGKTSAGSTELSKTRYPDTPPRFVIDLSLPPEQRYLEVCAVFNQEVNGLTPLFDEVVGGMLYRVPLIWVHLVCRLLLRRVHDGDENRELKGISKATGVPMYLLVCFNVLLDLFMGCSSGGAAVKDEEKGGTKMLHFRTLDWGMPSLRKVVIQLDFKTSHDGPIVASSLTYAGYVGVLTGVRMHMSLSLNFRPNRNEKGHFWPDSRYYWHLLMVLLGHRRSISSELRRFLIPRRKKHFWPSGSPEAWEIWTYEDIVKIVTHADEARVPLKSTACYLCFSNGVETTVVEKDYRTAIARASDNFVVVTNTDADRPDSTATQSSSGTQYSRDTYKTTGTDNSTAGTSNYEQKAPTGMEDLLSEAKDRQQCAEHNYYNLRAKKARRSMTADDMKQLVTEEEVISLVQSYPTTNEETHFACVMDPTEGNVKWCRRWVKPISAKWIRSHMRRMDWSEDVTFNIAPTVGQVMLMGTWSIHTAVTTSTSTRPIPSPSSSSSSIPVTLIHLPVSDPYCLPPRRGVPSVVVIFLLPVQTTPATRPGLLSTRFFSIVQGTRTLVRRVRNFTSDISPSMATAHAPMARVPFAPIDNPRLQHLASAKNRQNGLFTHKSSTTDAKSSSNSMKSGHISITTATTSSHKRAHDSSTYDDDCDSENVDPAMFDSPSKKIKGSMFAHSTTKPFTYSSGSSHHTPARISMPPPSSSTFSSPRSSHTPLRANMSSPRAPMTAPAGRSPQRKRAGLKSTRRTSAPFSRVNPPSFNSTSAFALPFSLDAALSSSLPGSTPASTPTPNMSGATIAESMPKTWLFEIYEDSPEEEAANLMEHSTLTLDLSSDDEDGKKVDDYRGKENTPPEGYDAPTASRSSSSTTPLPVLGSKKDIVRKKVVKDEMDDGSRSPLSDLETEDFYPEGLTKDSFVLVDEVVEEPAAALTDAKEVLYGAVTAKVVTALDKDEIVIWQDKEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1QIY6</accession>
    <name>N1QIY6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_129973</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765287.1">
        <property type="nucleotide sequence ID" value="XM_016902319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QIY6"/>
    <dbReference type="GeneID" id="27899456"/>
    <dbReference type="HOGENOM" id="CLU_549804_0_0_1"/>
    <dbReference type="OMA" id="ELIPRAF"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052635">
        <property type="entry name" value="Sec_Metab_Biosynth_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39607:SF3">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39607">
        <property type="entry name" value="XANTHOCILLIN BIOSYNTHESIS CLUSTER TRANSCRIPTION FACTOR XANC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="41"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF17166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="417" mass="44486" checksum="F332CA6A83AB7AFD" modified="2013-06-26" version="1">MMSDHCAVSEVPSAEADATSHYEREHASEPDARADDWAHTADRKAKKRMQNRVAQRSYRQRMKARVEELQAKVEQLEGSSSSPPLQPSCSTSSSSSSLSSSSSSSASSSSSASSSSSSASTAPSSCSSAAVTAKQRGASISMSPTASLRVATAATDHSCTFPPRRDSQLSTGYPSGAPAANMMPSSSPNDTRDHTIAMMGLSPVDSRSHPSHHHHMAAFGMLSNNSGRHDMSASSMALDSLHLPSHSTPFGDHPTQCFDYFGDVHGTHATQPDYMDAVTYQDCRTMTSTSMGTSREESPSNFLSPASLSDLHSPNDSYRSSSMTSVDLPLAPSAAHISSGSSVEERVKYVSEQAKLAGFPDLDAMITAYYTVLAGDHSGALGDGEGIVSRRLPRLIATLRHAVQEWRDWERKGFPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJ51</accession>
    <name>N1QJ51_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_150651</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758725.1">
        <property type="nucleotide sequence ID" value="XM_016906313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJ51"/>
    <dbReference type="STRING" id="692275.N1QJ51"/>
    <dbReference type="GeneID" id="27903450"/>
    <dbReference type="eggNOG" id="ENOG502S28F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063732_0_0_1"/>
    <dbReference type="OMA" id="PEAFAIN"/>
    <dbReference type="OrthoDB" id="2432613at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042546">
        <property type="term" value="P:cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045328">
        <property type="entry name" value="Kre9/Knh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008659">
        <property type="entry name" value="Kre9/Knh1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28154">
        <property type="entry name" value="CELL WALL SYNTHESIS PROTEIN KNH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28154:SF1">
        <property type="entry name" value="CELL WALL SYNTHESIS PROTEIN KNH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05390">
        <property type="entry name" value="Kre9_KNH1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110879" evidence="3">
        <location>
            <begin position="20"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="5">
        <location>
            <begin position="25"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1 C-terminal" evidence="4">
        <location>
            <begin position="174"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF10604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="263" mass="26854" checksum="E5D475B82FED4B42" modified="2013-06-26" version="1">MRSSTLLPVITTLAATVLADVKFTSPAPGASIPAGTLTVKWEESGDTPKISDLSTYTLQLMVGGNTDASSVGLLSLSTKGSHAQGTTAQGTVPANIAGTLKNGFYLKMISTAKEGGTVTNFSGRFSIEGLTGTTAANAVTGAQAVTGTDGPDTIDNVANDAAAAAPAAGAGDDMYGIAYADQSGLTKYAPMQGVPPTKITAQNFSPKYPTSSVSIATTWLPKPTVQTTMTQTQTFSVSSMENTAAPQAGPSGDMQKFLNRWKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJ69</accession>
    <name>N1QJ69_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_77274</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765356.1">
        <property type="nucleotide sequence ID" value="XM_016910159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJ69"/>
    <dbReference type="STRING" id="692275.N1QJ69"/>
    <dbReference type="GeneID" id="27907296"/>
    <dbReference type="HOGENOM" id="CLU_2747169_0_0_1"/>
    <dbReference type="OrthoDB" id="2906425at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF17235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="71" mass="8123" checksum="015DFA7B9C14DD91" modified="2013-06-26" version="1" fragment="single">PITNNVANQHREETCIAITSERKCFHPGNSFVKRSLRPFEWQVSHIKGTIHVPRLGNERLLNEAAALAYVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJI7</accession>
    <name>N1QJI7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF410-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_149793</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GET4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760101.1">
        <property type="nucleotide sequence ID" value="XM_016905772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJI7"/>
    <dbReference type="STRING" id="692275.N1QJI7"/>
    <dbReference type="GeneID" id="27902909"/>
    <dbReference type="eggNOG" id="KOG3024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046061_0_2_1"/>
    <dbReference type="OMA" id="LMDMMGM"/>
    <dbReference type="OrthoDB" id="10252405at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072380">
        <property type="term" value="C:TRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045048">
        <property type="term" value="P:protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000060">
        <property type="entry name" value="Golgi to ER traffic protein 4 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007317">
        <property type="entry name" value="GET4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12875">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12875:SF0">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04190">
        <property type="entry name" value="GET4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="303"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF11980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="337" mass="36965" checksum="DA2016D3C19E00E8" modified="2013-06-26" version="1">MSAKIQKVLARQKAKIEEGDYYEAHQQLRTIANRYVKSDPPAAIDILYNGALMLLKAGQGGSGADLSIYLIEVYGKGELKPDTANKARLMSLLRAFPPNEPGKKKFVTGIVEWSSKNGEFPAGDPELHHVIGTLYAEEGEVYDAERHLTLGTSDSAQVFADLEYTWYSDDEPSTASHYAARAVFPYLVIGNTRAANKALLLFTSRLSTSHPGLGVQSISSPSSDIRIYPSLPLLNFLGLLLLAVQRGSSDLFKQLKQHYAAHLKEVPAWDEPLLQVGEMYFGIKIPSQSNPMFDMMSNMLMGGNNPFAQKRREPARVGQAASEEKPSTPQPPAPGVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJQ4</accession>
    <name>N1QJQ4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteophosphoglycan 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_164351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760156.1">
        <property type="nucleotide sequence ID" value="XM_016908111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJQ4"/>
    <dbReference type="GeneID" id="27905248"/>
    <dbReference type="eggNOG" id="ENOG502SC1U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_553191_0_0_1"/>
    <dbReference type="OMA" id="YATPMRT"/>
    <dbReference type="OrthoDB" id="2142961at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016071">
        <property type="term" value="P:mRNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028322">
        <property type="entry name" value="PNRC-like_rgn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15365">
        <property type="entry name" value="PNRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF12035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="455" mass="48577" checksum="11E1EFE2251324AB" modified="2013-06-26" version="1">MAGYASETAPGAEQGRQHQSTTPAPKRNNRGRKNNQPTVQADGAMSDGALINPAPSPRPKKTKQRQSAATAPAQQQHENMGQGNVRRARPVSYAGGRIPATPAKEQAYAGPTFQASPAASALPMPKFSKSVPNAGMRGSLSARLAAEKKSDAEQSSPETDVAAPAPPPQETMNSPLDLFFKADREEKARSGSESLSPQMARRSQPPATEPRNAFGPKRQNVFLNDINGDSDMPSPRTVPTNNHRPYLEHRAASSPGAPQHTADFGEEERRANTQFLKNMLFSAATRPTKTPNSSQVRTASSGSATPNGHFNSPSPFNQPGSQSRHSVGPMTPLPTFEQQQDNSSLHYGNRNLSPLFKASRSETPPRSSSLRQEVASDADSGVAIGDSYSPTTYARNYLHQTANTAGPVEMPQLPFNNHPASFCGPSIGSSTQPINAQHGVPAQAASTNKEENHEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJR9</accession>
    <name>N1QJR9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cupin 2 conserved barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_137294</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764648.1">
        <property type="nucleotide sequence ID" value="XM_016902834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJR9"/>
    <dbReference type="GeneID" id="27899971"/>
    <dbReference type="eggNOG" id="ENOG502SRGT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158082_0_0_1"/>
    <dbReference type="OMA" id="QVRSWGF"/>
    <dbReference type="OrthoDB" id="5270965at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40434:SF1">
        <property type="entry name" value="CUPIN TYPE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40434">
        <property type="entry name" value="CUPIN_2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF16527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="91" mass="10070" checksum="C8F42D9330160522" modified="2013-06-26" version="1">MSRKEAEEQVSSWGFQHVFTWSDRANAHYPPHAHAGLTTHLILSGELTITYPDDANPSKETFGPGSRLDVDAKRRHEVFVGSAGCTYVIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJV6</accession>
    <name>N1QJV6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_32050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765606.1">
        <property type="nucleotide sequence ID" value="XM_016908479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJV6"/>
    <dbReference type="STRING" id="692275.N1QJV6"/>
    <dbReference type="GeneID" id="27905616"/>
    <dbReference type="eggNOG" id="ENOG502SF32">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070640_0_0_1"/>
    <dbReference type="OMA" id="TPEEWWV"/>
    <dbReference type="OrthoDB" id="1733656at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110896" evidence="2">
        <location>
            <begin position="17"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF17485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="275" mass="29215" checksum="52BA033D787213EA" modified="2013-06-26" version="1">MRASTLILALPALAAAQQQIPILDQVADRVKGWLSRATASVSAVVEKASTQASVADPVAAAAATVVDLKVERLTLENHKDLIQPGASTAAPGIETWEVFVTGGNKTCYGRCTRAETAFNESVLLLAASTNPPPPRLALLDCESDGVLCHAWAVSPPSILHLQLPQPLADQSTPASTVRSIRLNSTTVTAPQIAALHLEEKYLETEPYEGYFHPFDGPLAEYGLQIPLGYAVHYFSMIPSWAFMIGISFFSRSIMGRRMTPAAPQANAGPAAAAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>N1QK23</accession>
    <name>N1QK23_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">H/ACA ribonucleoprotein complex subunit CBF5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Centromere-binding factor 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">H/ACA ribonucleoprotein complex subunit cbf5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">H/ACA snoRNP protein CBF5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Small nucleolar RNP protein CBF5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SEPMUDRAFT_67800</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs and play a central role in ribosomal RNA processing. The H/ACA snoRNP complex also mediates pseudouridylation of other types of RNAs. Catalyzes pseudouridylation at position 93 in U2 snRNA. Also catalyzes pseudouridylation of mRNAs; H/ACA-type snoRNAs probably guide pseudouridylation of mRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>uridine in 5S rRNA = pseudouridine in 5S rRNA</text>
            <dbReference type="Rhea" id="RHEA:47036"/>
            <dbReference type="Rhea" id="RHEA-COMP:11730"/>
            <dbReference type="Rhea" id="RHEA-COMP:11731"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>uridine in snRNA = pseudouridine in snRNA</text>
            <dbReference type="Rhea" id="RHEA:51124"/>
            <dbReference type="Rhea" id="RHEA-COMP:12891"/>
            <dbReference type="Rhea" id="RHEA-COMP:12892"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pseudouridine synthase TruB family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760281.1">
        <property type="nucleotide sequence ID" value="XM_016909793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QK23"/>
    <dbReference type="STRING" id="692275.N1QK23"/>
    <dbReference type="GeneID" id="27906930"/>
    <dbReference type="eggNOG" id="KOG2529">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032087_3_2_1"/>
    <dbReference type="OMA" id="KYGRTNE"/>
    <dbReference type="OrthoDB" id="10250002at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000495">
        <property type="term" value="P:box H/ACA sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031118">
        <property type="term" value="P:rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02572">
        <property type="entry name" value="PseudoU_synth_hDyskerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21148">
        <property type="entry name" value="PUA_Cbf5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2350.10:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012960">
        <property type="entry name" value="Dyskerin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004802">
        <property type="entry name" value="tRNA_PsdUridine_synth_B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00425">
        <property type="entry name" value="CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003280">
        <property type="entry name" value="PRK04270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127">
        <property type="entry name" value="CENTROMERE/MICROTUBULE BINDING PROTEIN CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127:SF0">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT DKC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08068">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01136">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dyskerin-like" evidence="14">
        <location>
            <begin position="28"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="PUA" evidence="13">
        <location>
            <begin position="279"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="431"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="369"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="455"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="465"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="476"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="490"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00056777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00072225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00077661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00081789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMF12160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="499" mass="55425" checksum="80E5BC2C50115388" modified="2013-06-26" version="1">MSLVKVKKGEEEEDSMIIKPEAVGSNVDTSHWPLLLKNWDQLLIRTGHFTPIPAGCTPLKRDLKSYVSSGVINLDKPSNPSSHEVVAWLKRILRVDRTGHSGTLDPKVTGCLIVCIDRATRLVKSQQGAGKEYVAVLRLHDKLPGGRAQLARALETLTGALFQRPPLISAVKRQLRIRTIHESKLIEFDNDRQLAVFWVSCEAGTYIRTLCVHLGLLLGVGGHMQELRRVRSGAMKEDDGNMVTLHDCLDAQYLYDNQRDESYLRTVIQPLETLLTTYKRIVVKDSAVNAVCYGAKLMIPGLLRYEAGIEVYEEVVLMTTKGEAIALAIAQMSTVELSSCDHGVVAKVKRCIMERDLYPRRWGMGPVATEKKKMKESGKLDKYGRTNEQTPAQWKLEYKDLNEPNAEAQAAEGAAVKEGITGKVKELTSAEDVLMAEPVNPATGEDEGASEKKAKKEKKEKKRKHEDETPEEKAARKAKKAAKKEKRKSTATAGSDDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKH1</accession>
    <name>N1QKH1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nap family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_149991</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the nucleosome assembly protein (NAP) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760416.1">
        <property type="nucleotide sequence ID" value="XM_016905895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QKH1"/>
    <dbReference type="STRING" id="692275.N1QKH1"/>
    <dbReference type="GeneID" id="27903032"/>
    <dbReference type="eggNOG" id="KOG1508">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038163_0_0_1"/>
    <dbReference type="OMA" id="RFTFEFK"/>
    <dbReference type="OrthoDB" id="19419at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.90">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037231">
        <property type="entry name" value="NAP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002164">
        <property type="entry name" value="NAP_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11875">
        <property type="entry name" value="TESTIS-SPECIFIC Y-ENCODED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00956">
        <property type="entry name" value="NAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143113">
        <property type="entry name" value="NAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="327"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="278"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF12295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="388" mass="43499" checksum="2E1DBFF4C9577EAB" modified="2013-06-26" version="1">MADTEISPLVTYEELAAIEMDFEDIDNQIMIKQYQLSKSAYARRSAAISKIPNFWPLVIEASPPELDSFVHPQDSKIFAESLTSIEITRPEIDSSASASASATPKGEFKGHPRSFQITFTFSPNAYFSNSTLTKTFHYRRASDGWCNLVSEPVRIDWKNPEQDLSEGLTDAAYALFHARKNATTSTSTTTSTTGGEAGDPTSLSMQQKSLPEYSHLLTLLTSKNGHNTSFFTWFGFVSSRRWVSAEESEKAWEEFYGKLEAVRKGEKISLVAAKDGDKDDEDDEEDDEEEEEYGDQAVEVFENGDDVAAVLAEEIWPNAIKYFTQAQEMSESDGLSYDEDDDDEVESEDGEEEEVDMQALVAEANNQKTEKKKKRQSDVGFPSKKQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKQ6</accession>
    <name>N1QKQ6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal peptidase complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_146001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPCS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764993.1">
        <property type="nucleotide sequence ID" value="XM_016903396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QKQ6"/>
    <dbReference type="STRING" id="692275.N1QKQ6"/>
    <dbReference type="GeneID" id="27900533"/>
    <dbReference type="eggNOG" id="ENOG502S2C7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089740_0_0_1"/>
    <dbReference type="OMA" id="KHACDDA"/>
    <dbReference type="OrthoDB" id="29558at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009582">
        <property type="entry name" value="Spc2/SPCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 25 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06703">
        <property type="entry name" value="SPC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF16872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="223" mass="24630" checksum="828FA24DB9B72F17" modified="2013-06-26" version="1">MAERISPHNLSELKNTTDDALGNYLRSLGFQQDNTKLDVRLALGYVAVTIAGVTFAADYKLGWDATKFWTAVAVAAYAVFNGALTYWMWAVEKGLVFEGTRSGKKISIYSRTKKHDPTYYLEIHTSSSPETKEVTTREIQVPFTTWFTKDGFFVAKPFQQWLASSVEVVGDADLKNANRLERDELAAPTAEFELLQAANGQAATGMEGPGAGKSSQRKSKRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1QL55</accession>
    <name>N1QL55_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_146826</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016766036.1">
        <property type="nucleotide sequence ID" value="XM_016903890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QL55"/>
    <dbReference type="STRING" id="692275.N1QL55"/>
    <dbReference type="GeneID" id="27901027"/>
    <dbReference type="eggNOG" id="KOG0591">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_23_1"/>
    <dbReference type="OMA" id="EMEWHAR"/>
    <dbReference type="OrthoDB" id="10250725at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08217">
        <property type="entry name" value="STKc_Nek2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051131">
        <property type="entry name" value="NEK_Ser/Thr_kinase_NIMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899">
        <property type="entry name" value="CAMK FAMILY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899:SF10">
        <property type="entry name" value="NIMA-RELATED KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="7"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="398"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="450"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="312"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="398"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF17915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="606" mass="67774" checksum="2D2EBE11FA4DD212" modified="2013-06-26" version="1">MATDNDYDVLEKIGQGSFGVIRKVRRKTDGEVICRKEISYTRMSDREKEQLHAELRILESLRHPNIVQYYHRQHLKSSHDLHLYMEYCGNGDLGGYIRKLKDRNKMADEDFIWSIFAQLVGALYRCHYGEDPPPAGKEGNVRKGKALVSKQGHTVILHRDLKPENVFLGDNNSVKLGDFGLSKIIASHDFASTYVGTPFYMSPEICAAERYSHHSDIWSMGCIIYELASRQVPFEARSHMELVLKIKKGYIKPLPAQYSQDLTDVISWCLKTDPRQRPDCAQLLGVANIKVARTRLEQASALGQLGKLQTDRDSAFAKLAAAQKQIQELQSEVAKLREANKKVEMEWHARATLAIDQKVHEAHEKNKADLLIQFDSAVEKRAEEKLALHLASIPTTTNESLASTHIRSSTPPPARRDISNFSGFSNKVPDTDASSLPDLDESIIEQDLTSLSLGDNGLETPDEMVSPLANRTTKLPPKKRERKPFVRAKTFANCNAVAAHRDSPMDVHMADPSPAHHPAIHMRGFVSPRKGGRELPLKRNIFSAAAAIAEKENMRPPTSTTSAVRGRTLVELSSAKSASALQSPAKWIGNPAILEDMMPSPFVKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1QLF4</accession>
    <name>N1QLF4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NTF2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_149834</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760172.1">
        <property type="nucleotide sequence ID" value="XM_016905799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QLF4"/>
    <dbReference type="GeneID" id="27902936"/>
    <dbReference type="eggNOG" id="ENOG502SB73">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096573_0_0_1"/>
    <dbReference type="OMA" id="DAYVRMI"/>
    <dbReference type="OrthoDB" id="5596743at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058645">
        <property type="entry name" value="NTF2-like_dom_7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26534">
        <property type="entry name" value="NTF2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110964" description="NTF2-like domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="NTF2-like" evidence="3">
        <location>
            <begin position="43"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF12051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="221" mass="23154" checksum="70DB03BE7D50FD9F" modified="2013-06-26" version="1">MLTTTILSFAGLAAASMCSAMPSGGQNGASHQQKQGGGGGQPCLDDGAAQKVAENFRSLITNYSNASAAAYLTEDFHDYSDGVNTLINSGCPNGPQPLGSPTFTSLESFQAGQGSQPNIPFEILNVWHGCDFVAMRWKSPQPQATGPTPQEQVQGIIVMEVCQGGEQEAWVIDTVYSEFNSGAWLYDLEVFKPTCDASGAPIAKASKRGLGGVIGSPVKML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1QLX6</accession>
    <name>N1QLX6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAM192A/Fyv6 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_129237</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764380.1">
        <property type="nucleotide sequence ID" value="XM_016902268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QLX6"/>
    <dbReference type="STRING" id="692275.N1QLX6"/>
    <dbReference type="GeneID" id="27899405"/>
    <dbReference type="eggNOG" id="KOG4036">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067596_0_0_1"/>
    <dbReference type="OMA" id="SKKSQEW"/>
    <dbReference type="OrthoDB" id="75807at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039845">
        <property type="entry name" value="FAM192A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019331">
        <property type="entry name" value="FAM192A/Fyv6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13495">
        <property type="entry name" value="NEFA-INTERACTING NUCLEAR PROTEIN NIP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13495:SF0">
        <property type="entry name" value="PSME3-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10187">
        <property type="entry name" value="FAM192A_Fyv6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM192A/Fyv6 N-terminal" evidence="4">
        <location>
            <begin position="4"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="94"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="199"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="212"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="225"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF16259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="307" mass="32222" checksum="9702E3003EBEF140" modified="2013-06-26" version="1">MSRFVSANANADSTSEEDIRWLAAQAAIEATRSQPRLPPGQQEGGKSLFETLEANKAAKQEAFEQSLRLTNQFQSLDEDDVEFLDSVLEATKRKEAEIRRETRESLEAFRQRQADAERSAASIAAAGESSSNTAASGTGAGDEDTTTTWKVGRKRRKGKEDGVFGGVKLRKASSSTTTTTITATTPDGGGGGGGGGGRIKKETTEVDKEEKEEKEEEEKEDDTAAGQSAKVSNNQAALKPLDSKSTSSNESGAAAAAEKPKQDEPGATAAATRPKQDKPGITSATSPPSTIGLAGLVAYGSSDEDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1QM57</accession>
    <name>N1QM57_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1690-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_146399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765478.1">
        <property type="nucleotide sequence ID" value="XM_016903630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QM57"/>
    <dbReference type="GeneID" id="27900767"/>
    <dbReference type="eggNOG" id="ENOG502SDJV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093897_0_0_1"/>
    <dbReference type="OMA" id="GKSLNCW"/>
    <dbReference type="OrthoDB" id="5544375at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012471">
        <property type="entry name" value="DUF1690"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07956">
        <property type="entry name" value="DUF1690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF17357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="21951" checksum="D6CCBCF48C6601BF" modified="2013-06-26" version="1">MGNAASSSSPAHTLNADAPVRLSQSVINSLQNSPETDSTRAQQHELHTQTRITADLQRIRDSQAQKLDAITTALTNTEPQQDSASDSEALSKPTGLLAHLSSPFYHDWSQENSKPATRESDRSHDSVSKEIMDLRQRLEQRKKVDKVPAEVEKAKNSLVQCLRDNDKRPLDCWQEVEAFKREVGKLEHAFIQKAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>N1QMP7</accession>
    <name>N1QMP7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SEPMUDRAFT_146611</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 18">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 18">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765768.1">
        <property type="nucleotide sequence ID" value="XM_016903767.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.N1QMP7"/>
    <dbReference type="GeneID" id="27900904"/>
    <dbReference type="eggNOG" id="KOG0605">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000709_0_0_1"/>
    <dbReference type="OMA" id="HNRRFVG"/>
    <dbReference type="OrthoDB" id="162894at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901992">
        <property type="term" value="P:positive regulation of mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05611">
        <property type="entry name" value="STKc_Rim15_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000340">
        <property type="entry name" value="Serine threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000664">
        <property type="entry name" value="Serine threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000139">
        <property type="entry name" value="Serine threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:001008">
        <property type="entry name" value="Serine/threonine-protein kinase cek1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE GREATWALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="14">
        <location>
            <begin position="43"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="752"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="15">
        <location>
            <begin position="1185"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="13">
        <location>
            <begin position="1552"/>
            <end position="1666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="123"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="301"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="488"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="550"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="707"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="909"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1227"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1319"/>
            <end position="1425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1463"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1499"/>
            <end position="1518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1669"/>
            <end position="1710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1776"/>
            <end position="1879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="488"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="561"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="601"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="624"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="707"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="932"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1014"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1035"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1050"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1319"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1357"/>
            <end position="1376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1377"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1405"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1695"/>
            <end position="1710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1812"/>
            <end position="1822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1841"/>
            <end position="1851"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMF17647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1923" mass="209793" checksum="8C49DB44D806E7F5" modified="2013-06-26" version="1">MAEEQQQPLAPPAVAALREDGSRGGVNAKGIMSRTISMDIREEREDLKRAAEQSLNAILELDLDGRVRWVSPSWQEVTGSAASTIIGKLVSEVVVDDPSVFAGCVEAMRKDDSKSHFIRFTVHPSPSADGEDVPSGDEKTPVEPRAGLDSMPGTKNDISEEHEETIELEAQGIMVYDRTTGEESHTMWMVKPAVSREVTIDLPQVLVDSLGIGAEMLANYLTLLADVGVHDPANHPPPLPVLCRICERQITPWWFEKHTELCSQEHRAEMEVQMAQESLNEQRSAIVKVLDAMEAQSRLAQPIGLEPTSPSAPPKAEYKGLPIGHSSSPSSGPSSGRASPAQVGRSRESSASGLSHHRARSFAVRRPLARIVELVLDICDTAMEISTPAIKDTKGYATGEFRTQSPQSESRIQQVLQTPSPSAGLSDHEQGLALLCDDTHRLARAKVEAVFRHRRILEYSERIRVEYDILVQECIEAALQKAARVAAGELSDSSSSEGENGNASEPERGMESSFEMVGDALDHSMADEMFSMSSYKSPAGHSAMAMALRNSSDDALRRRASSLNSSRASSPRAGATTPRSSYAGPTDPFPMHKRSSVALESDTGGDSDSSMRSSVASGSHKRTQSPSAELSLSRVASTRSRDRKRHSLILPSLQNAGGHSPARAPPPPSSPLRMAKPRLPSGADGLPSPITSPVLAHSEFNSPVIRAHHHHHHRRQSSAAMSESFGRPASPRLSAVMSNPQPRAIQTSIKDFEIIKPISKGAFGSVYLSKKKSTGDYFAIKVLKKADMVAKNQVTNVKAERAIMMWQGESDFVAKLYWTFSSKDYLYLVMEYLNGGDCASLIKVLGALPEDWTKKYIGEVVLCVQHLHSRQIVHRDLKPDNLLIDAKGHLKLTDFGLSRMGLIGRQKRAINAKPGDAPPDLLKAGPFRRAPSVTSSRSTSLDYQGAQHSPVQTPATTPAICHDHNQPSYFSLYREGSREPSRRTSGQRSDSGDSEALSAMFRRFSVADGRTPIEEETASDEGGSESPDPYALQPVASNSSSSMPRNDTPPHQPPSTQMPPPMMALFDPEDSDRRFVGTPDYLAPETISGAGQDEMSDWWSLGCILFECLYGRPPFNADTPEEVFQNILTRNIRWPPEDEDDPVSENAKDLMNKLMCVDPKERLGSNKDEKYASGGDEIKAHPWFAEIHWDTLREDEASFIPMSENPEDTEYFDARGATMQNFAAEFEDQATSPSQTPGADYPDRPHDALSRVRNQVNSAKRNLMPLHIPPHVRDARSRRLSEPVVQDDFGNFQFKNLPVLEKANKDVIQKLRADAMQAQAKTASAAPSTNSSAVVSPSPGPGLDSSPIAPAPLKRTLSANKNAHRPNSTSALNQANPSPSRGSQPSSPLLVSFSAGQTQERRKTSSGSSSLSQQAGPSLQPGHVLDQAPRLPVTFKANSSAPSPIKGGKTNSVHLPMQHDRATLGHRHPSISSPRPRSHTLGSQDQDGGLVPEILPAHHHKRRSGVFDVSPSSSDNEETRAKALLRVQRRRQSSRRLSQISLADGPSFRTLDVLVCEDHPVSRLVMERLLEKLRCRTIAVTNGSEAMRYAMSEVKFDIIMMEYKLPQVNGADVARMIRDTKNANSHTPIVAVTGYLKELHAPHSFDALVEKPPTKEKLEEVMGRLCQWKTPPEGWKPSAPQAIPPSIKRHEALPSDNSPTTTASSGFTGFNSIFSGTRENSIGSSSLGEPDDLPSIPLIISRQPTTELDQSELERNFGGLGISHGIRVDDQHRRLSTANSDHQMSPPAALESADAPAPRKSPSYEAIAAKRKSLEKVRHESAAESGDDEDEELGNVQIRQRSPKRNVKRTSKLGTEMMRTNSQGSVVSADDHPLSTSSPSTVLEKTIVEEPSASLTPPFVFSPRPGDHVETIDMAAVDAQSNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1QMT8</accession>
    <name>N1QMT8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">A to I editase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_160636</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765474.1">
        <property type="nucleotide sequence ID" value="XM_016907900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QMT8"/>
    <dbReference type="STRING" id="692275.N1QMT8"/>
    <dbReference type="GeneID" id="27905037"/>
    <dbReference type="eggNOG" id="KOG2777">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005382_2_1_1"/>
    <dbReference type="OMA" id="PDIKIYM"/>
    <dbReference type="OrthoDB" id="10268011at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043829">
        <property type="term" value="F:tRNA-specific adenosine-37 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002466">
        <property type="entry name" value="A_deamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042935">
        <property type="entry name" value="Tad1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47803">
        <property type="entry name" value="TRNA-SPECIFIC ADENOSINE DEAMINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47803:SF1">
        <property type="entry name" value="TRNA-SPECIFIC ADENOSINE DEAMINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02137">
        <property type="entry name" value="A_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00552">
        <property type="entry name" value="ADEAMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50141">
        <property type="entry name" value="A_DEAMIN_EDITASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A to I editase" evidence="2">
        <location>
            <begin position="56"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF17353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="412" mass="45818" checksum="4A628F2A5DBA50B9" modified="2013-06-26" version="1">MSKADLIAECVLKTFEALPTKFKPRTLPAGQREWVPLAGIVLSRGELSAATVTCAALATGMKCLPQSKLHLAQGNILHDWHAEILALRSFNRFLVDECVDLAKRGRGEHGQWVRWGQWRADEPPFALHDDVKIHMYCSEAPCGDASMELTMSEQTDATPWKKQQYVGVDGLLGRGNFDQLGVVRRKPSRPDAPQCLSKSCSDKLALKQCTGLLSAVLALLVHPRNVYLSTLVLPEKQVFCTAMERSFGRTGRMNLLAENEIQGSWQRYGYCFTPFEVQTTTATFAFSKPPKNDLAVSSNLSAVYTPQHQEVLINGVLQGRKLLDARGASCVSRRRMWQAVRDVIASAEVAHATIASEAQTYAELKQSPLLKGREIVKRDVRTLSLKGWKSNQGDESWNITTKSEERVEPSVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>N1QMT9</accession>
    <name>N1QMT9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_130396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765818.1">
        <property type="nucleotide sequence ID" value="XM_016902355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QMT9"/>
    <dbReference type="STRING" id="692275.N1QMT9"/>
    <dbReference type="GeneID" id="27899492"/>
    <dbReference type="eggNOG" id="ENOG502S7U4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_451404_0_0_1"/>
    <dbReference type="OMA" id="THERGHW"/>
    <dbReference type="OrthoDB" id="5395975at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="380"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF17697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="605" mass="66581" checksum="4E2FBB47942B4468" modified="2013-06-26" version="1">MTKDNTRFVPLVAAPPLRPRRQRLSWKWDLDARGMERCGTKLLVHAGAPSSKRQDDGYIAQAEAYASALEGHRGRVRIWEAREDRRLLTVEPGAGEATKALEDMTSIEDQVQASSQVNQNFEQAELERSSTKRLRAPDSLEYIDDTQLACTALESQLFASSPVVAAHTGTSKDVHSVVSSVENRGSSSQQQARSSGKGCTQRSPLARKPASVSTSTTPPRRRAESAPVSQSSYIRTPLSGRASKRVRRESPERHDFEPANLFRPIQEQPLPRPDPSGQASTIALGHHSGDENSAEGTTFSDETTSELPTSYSVSDLVSDSQGNSLQDRVRNGRSNSDPGPVSHSLDDTFDPPSDLLQSEQRDVTVEEPFAEVRASEPNPADAGSGDADQSDVGASPVHVQEQVPHDSTRANAYLDNDHKAPRPRHVDPSAEVEEAPSELLELATEIHAPRPTTSAKTFKTYITKELRDLHDSLASKFSPTMASRPISTHERGHWLIDCVSWRPTKKLTFWHHLECWIGNGSAGWGVWCTRGSDQYLVPSNSLARPSNAADARGQFRFVRVYCWGETVSHIYVLLYTASEGSVRKLGLQWIDSKGDVVVRMKGPND</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNJ2</accession>
    <name>N1QNJ2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_146385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765455.1">
        <property type="nucleotide sequence ID" value="XM_016903620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNJ2"/>
    <dbReference type="STRING" id="692275.N1QNJ2"/>
    <dbReference type="GeneID" id="27900757"/>
    <dbReference type="eggNOG" id="ENOG502SFXK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1143146_0_0_1"/>
    <dbReference type="OrthoDB" id="5412288at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF17334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="243" mass="27262" checksum="509DF9E44ED9A990" modified="2013-06-26" version="1">MQEQVPSAPDVFPEQIDGRTPPPRDHPQRQELGTRDWSEVLGVAALVGCDQSIVARAAGRCAALFDESMTFRTMPDASAGEAREYYSQQYRNGLGAVSSSDGIKKDVLTLDANIHGHYCPHASCARHREPFLQRWRLREHLKRKHEQIDFGNYDMVGKAGQHVNPGDPSNILVDNKDQLAENLQECALLPSVETVENEEYLQPVLINIGRSKDRKVRRTPSREHLRRTSVVQDGATGDKEIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNK1</accession>
    <name>N1QNK1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Creatinase/aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_161008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765949.1">
        <property type="nucleotide sequence ID" value="XM_016907918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNK1"/>
    <dbReference type="STRING" id="692275.N1QNK1"/>
    <dbReference type="GeneID" id="27905055"/>
    <dbReference type="eggNOG" id="ENOG502RGXF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017266_2_0_1"/>
    <dbReference type="OMA" id="YYANVTQ"/>
    <dbReference type="OrthoDB" id="9995434at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050659">
        <property type="entry name" value="Peptidase_M24B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46112">
        <property type="entry name" value="AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46112:SF2">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="1">
        <location>
            <begin position="219"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF17828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="455" mass="50972" checksum="E41BC1AD8C462E9E" modified="2013-06-26" version="1">MILSPICPGKIILPLKDIPHHLTKFQRCSIRTLQQDTGLYFLASAKPLEMSEFMDRRQRLAEALHKDGFDAFAVEPGYTFSYYANVTQSQWEVWEPEERPFIMVVKPHLTDSGSIVANTTFLVPAFEAQRARLLQMPFPDEIDVVTYEEHWNPYSTLLHSPTFASHRHQKKTPPKMMVDEEMRDFISRGLAQHGFEVHGLGGSVERVRQTKSPAEIGILRAVNTGTVEAVRAMRKCLTPGLREDDVMSVLDNTMRSAGLDPFFDIVLFDENASNPHGGTDGTKVLEKETMVLIDVGAHLYGYSSDICRSFFPPFFPQVETTKQDIAALDDHHVQEKLHVWRIVFDAQTASLHALHENASCAAVDLAARQVIDNAGYGQAFTHRVGHGIGIKAHESPYLHKGNTATLLKAGMCFTSEPGIYLVDKFGIRHEDVLLVREDGLPELLTGKRASGPWDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNZ3</accession>
    <name>N1QNZ3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_113844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765990.1">
        <property type="nucleotide sequence ID" value="XM_016901057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNZ3"/>
    <dbReference type="GeneID" id="27898194"/>
    <dbReference type="eggNOG" id="ENOG502RHJT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_520888_0_0_1"/>
    <dbReference type="OMA" id="PLENIIW"/>
    <dbReference type="OrthoDB" id="3644869at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF17869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="523" mass="56352" checksum="09364B9AB731C2DD" modified="2013-06-26" version="1">MPRDREGLFYNAKQPKHSTSTSSSRRSSTTVDDKGCIITRGFVVPSRSSSQSSMARSTASSFETSGTPPTPTDSASPSFSRSTAFMSKSSLRRTSSSASSLRRSILASNRSERADLERRQTWQTDDSLSASHGSRLDDDDLAATLCCAQPAASSDVFLAPPAIAIPGVRADRAWQPHPLRQVAPVRRTKSEQTNLNNLTMRENRKARSKSAQDAPKRVANVKIVLREHADDAIASDSEDDDDECNTALSLRISAQRNRLDYATRRALTDEKNAAIMHRVQQVATPPELYSPISTPVPDASDITADLIQVCQKLERVYADNAIASDSESDDDYTCKGDPKMTAALQQAAIHGVHNAVATQIDAAAYMGVELQKRAMSDAGLASRVTDPSHSVKLSPHRRNVSAGNLTVRLIPPQSTKGAEVYEHDGKTPIEVATFDKGAVLAMRSLRPSKTRPKPTKGVLKKTGSPPSTGVSTAECSPSKNVQTRISHGKDVDGLLKPMPPPKLIFKQPAQSTASENGADKAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>N1QP05</accession>
    <name>N1QP05_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_146834</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016766050.1">
        <property type="nucleotide sequence ID" value="XM_016903896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QP05"/>
    <dbReference type="STRING" id="692275.N1QP05"/>
    <dbReference type="GeneID" id="27901033"/>
    <dbReference type="eggNOG" id="ENOG502QZJZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011099_0_0_1"/>
    <dbReference type="OMA" id="VDDNKWM"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF25">
        <property type="entry name" value="ABC-TRANSPORTER-REGULATING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="90"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="30"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="175"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="224"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="764"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="811"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1011"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="176"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="811"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="861"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="873"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="917"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1026"/>
            <end position="1035"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF17929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1041" mass="114581" checksum="4A0A4C482FBB77B7" modified="2013-06-26" version="1">MNPTHSSDAARTDSLTASSLPLYSAGAFDGASSMAMPGGSNGAQWFQRDIDYGDYDQDVNGEDGNADVDNDPDNDGGDQRDPKRRRIARACDMCRKKKIKCDGKMPKCSHCENYKTECIFTHVEKKRAPPKGAKYIEGLENRLGRMENLLRLSGLLAEDDGGRTDLGTLEKRLAEQTRTAKSNATSPQSQHSSMRQGSGGNSKESNTPAQNDALESTTLPQAASPAALNDNDKSSLPDLTKPSTDGSKKESGEVDVLADQMCSLITNNCGETRYIGSSSGFSIFSPKGIQWVNEKTGDTSFQSMIAHASSEDKQGWDHWKPEVFNDLFQRRIFRPLPGRQECYALLKDYFENFNCMFPLFHEPTFMHLVDKHYSLEPYDGSGWWASLNVALAIGHRLRVMSNVVPREEDEVAWAYLKNAMAVMSELTMRNTDLLSVQALLGMALFLQGTPNPQPTFFLVAAAIRLAHSIGLHKRGSGFNLNDVESEQRKRVFWIAYLLDKDICLRSGRPPVQDDDDMNVELPSENPVDNVGNVPLAQGGTMNLFRLMCQFAQIQSRVYKQLYSVKAGRQSDGELLNTIGELDASLEEWKDSIPIDFRPEHEIKAAHTPLILHVVVLHFAYYNCLTTIHRMSVHHGYWTSRLSDYAVQGLNARPLNPRVFMSAALCVNAARTSIGLIRYIPQGDYACVWLILYYPVSSLVTLFANILQNPQDARARTDLKLMSSVVAFLTMLERDVAEATGNVRRMLSVCAEFERIARVALDKAEREMRGRGKRKQAEREREKALKERVNGEIVQGIEEGKSLEQIQVETQASYRRPVQTPTLRASVSGSQAGSNPTNSPRSWGGSPPGGSGPENQPMHQLGQRSFSNPTPRMQNANLNANHQHQSNYMPSQQPHSASGPFNALQFPQNMSPMDFSGANGSPHQPFTSGPSPMDGGFGQQHHHHTGFSPQQTSGADFGIAFDPNNGVPGGPGPGGAFQQPFVPQDLWQMPMTLEWDWAEGLGLGAFTPGPMAFDPIGGAGGGGFAPDQQTPHSSSMGPPPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M3AR57</accession>
    <name>M3AR57_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">GMC oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_145262</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF07939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756060.1">
        <property type="nucleotide sequence ID" value="XM_016903096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AR57"/>
    <dbReference type="STRING" id="692275.M3AR57"/>
    <dbReference type="GeneID" id="27900233"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002865_6_3_1"/>
    <dbReference type="OMA" id="DYSECVM"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF138">
        <property type="entry name" value="DEHYDROGENASE PKFF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004031740" evidence="6">
        <location>
            <begin position="19"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="8">
        <location>
            <begin position="311"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="530"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="574"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="575"/>
            <end position="576"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF07939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="606" mass="66219" checksum="ECDCE816BBC6A889" modified="2013-05-01" version="1">MMFLLRLSIFTFCSIASAFDFGSISYTNHFGILGQNATFDYIVIGSGPGGMTVATRLAEANFSVALVEAGGFYENAVGNRTVTPGYYAENLGNIGNNWNFQTKPQPQLYNQSVRYDRGRTLGGTSALNAMLYQRPTRGSHERWAQTVNDSSYGWDAFLPYYQRSVNYTAPNAAVRAANASVPEPGAGAYSPLGGPVKVTHSNWATPFASWGQSALRELGLPEIRDFDTGELIGHQYCPLTINPDDQTRGSSEATILRQYLGNGRSNLQVYAHTMAKRVTFDGNKTATGVEVESYGQPYSLTATKEVIVAAGAFQSPQLLMVSGIGPAAELEEHNISTLSALEGVGKNMQDHILIGVYYRVQTLTTNDLQNATIARHYEELYRKNATGILASQNADYLGWDKLPSEYRNNVTANVREALDKYPTDWPDFEYVVGSTKNGFIQTALIAPQSTGNITISSSNTADPPIIDVGWLTNSIDVEMAIAAVRRGREFFATQAIQPVLAGEELKPGNNVTTDAELEEYVRKSVSTVYHASCTCAMGPRENSMAVIDSKARVYGVQGLRVVDASSFPFLTPGHPQSVIYALGEKIADDWQLAAIYTRATYRQQKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M3AS64</accession>
    <name>M3AS64_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_159278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756475.1">
        <property type="nucleotide sequence ID" value="XM_016907833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AS64"/>
    <dbReference type="GeneID" id="27904970"/>
    <dbReference type="HOGENOM" id="CLU_746328_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF08354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="371" mass="41322" checksum="27465AD532463724" modified="2013-05-01" version="1">MCALCRRSWEIALRVRGGRHLFILSKPSPFEGFVKRELQARPSRNEARTGLLLKSLSVPVIVVIQGAKVPLRKPAREGPVREGPVREDPVREGPVREDPVREGPVREGPVRRSAATHYQRLNSQPGSIGKGRVHPLLCCFDLSEVRLVREWKGDCTLDAASGSPECGCDLDATFGTAVAVIQYEERGVSILFHTVLISAKPDHPSRECERGCSVDAALGTVVAVIQEKEHKERGVSILCYAVSIPIKPNRFLRERRRGRTLDVAFGAVIVMIQSEEHEKGHVRPFTSCLCLCGALSQLYSHDSRGPVAIIWGEKHEERALWSQQPRPAAVIKGEKHEERGMLVLLILSVSVELLHSPMVKRRRRLGRRDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M3ATH8</accession>
    <name>M3ATH8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_136170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756940.1">
        <property type="nucleotide sequence ID" value="XM_016902759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3ATH8"/>
    <dbReference type="GeneID" id="27899896"/>
    <dbReference type="HOGENOM" id="CLU_1741721_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004031796" evidence="2">
        <location>
            <begin position="22"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF08819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="150" mass="16722" checksum="38665E3229D7D211" modified="2013-05-01" version="1">MMLGLLIQYGIIFAASTQAAAVKPCKHAHAHPLAALYDGAAAPPTNQEYSPERLEKPATHSEAVMAELKRLSDVHRHTRLHLHHHHINHSKEPTTPIDDAASHDEPSLTIAEPVTESHEQQQLPSDLLTEQEQEQTQTTSEESEKQDLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-09-13" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>M3ATK0</accession>
    <name>M3ATK0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_111327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756960.1">
        <property type="nucleotide sequence ID" value="XM_016900912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3ATK0"/>
    <dbReference type="GeneID" id="27898049"/>
    <dbReference type="HOGENOM" id="CLU_1846344_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004031071" description="Secreted protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF08839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="139" mass="14870" checksum="ECEA5A030C7D5FA0" modified="2013-05-01" version="1">MLLLLLLLMLMLLLVLLLLLVFALPTRPRPPASLAPSQRIARGGSSSSSTCTVVLSEAEKGHGRDATLCCATGNSSATHCTTARSLHRTIQAVRREAGASVHTFVSCPVPRPARCCSLSRHAARCPRKKKRQGEPCVCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M3ATZ5</accession>
    <name>M3ATZ5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="8">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_52665</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the tannase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757065.1">
        <property type="nucleotide sequence ID" value="XM_016909239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3ATZ5"/>
    <dbReference type="STRING" id="692275.M3ATZ5"/>
    <dbReference type="GeneID" id="27906376"/>
    <dbReference type="eggNOG" id="ENOG502SH94">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014819_3_2_1"/>
    <dbReference type="OMA" id="YSYWDGC"/>
    <dbReference type="OrthoDB" id="3039123at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF8">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF08944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="504" mass="55172" checksum="941C0D697A497081" modified="2013-05-01" version="1">MPLVVQQTGPLSFCNVTVIYTHPGHDDSVRVNVWLPLEEKEWNGNFFGQGGGGYAAGTDGALAPALSMGYAAANGDAGHSWYENALDSSSWATKSPHNVNYHLLSMLGHRSLEELTLIAKHVTESYYGKKIKYSYWSGCSTGGRQGMVLAQRYPTLYQGIYAVAPAMNWVTFIVAEFYPQIVMKALNYYPAACELNAITAAAVEACDELDGVKDGIISAPGQCKFDPQTIVGQEYDCAGSTRKITTEAAKIASATWSGPKDPDTGKSIWFGLTPDASLPGLDPNFGGLASTTCNEDSTECKPRPFPVAADWIRNWLLKDPAYDLSTIDEEQFHNLLITSYQEYTSAINTADPDLRRFQKSGGKLLSWHGLHDQVISPNGTSSYHDRVAALVGPNVKDFFRHFEAPGVAHCFGGPGAYPTTGFQDLVRWVEHDEPVEELVGRNIPWPGTDRTKIRPFARILCPWPQVASYKGGDEASLSSFECRDGFDLSKVKKKEEGKAAKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M3AWU9</accession>
    <name>M3AWU9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">T6SS Phospholipase effector Tle1-like catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_68578</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759316.1">
        <property type="nucleotide sequence ID" value="XM_016909829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AWU9"/>
    <dbReference type="STRING" id="692275.M3AWU9"/>
    <dbReference type="GeneID" id="27906966"/>
    <dbReference type="eggNOG" id="ENOG502RQSD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005049_1_1_1"/>
    <dbReference type="OMA" id="QTNEYIH"/>
    <dbReference type="OrthoDB" id="3057168at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF1">
        <property type="entry name" value="TLE1 PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="2">
        <location>
            <begin position="31"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="483"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="503"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF11195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="556" mass="63310" checksum="5B795FB60CC9BB59" modified="2013-05-01" version="1">MSTFSEAEPVTRERRSNSRALSRVRHVPPGKRIVLCEDGTWLNSSSDSLKNSVAIPSNITRLSRAIKPVSSDGIQQVVYYHWGVGAGGGVTNKLLGISGEGLAQIVREGYQFIANNYQPGDEIFIFGFSRGAFSARSIAGLIGDVGVLTKEGLPYLAEIFRDAQHQHEPDYRPKHPDLPFPDKPSVASPVYLRELVRRRLTIPDVRVRVVGVWDTVGSLGTPKIGWLSRVGLQSDRMKELSFYDTSLGNHIDYAFQALALDERRFAFPPTLWEKFEDNSTTLRQVWFPGAHSNVGGGYDDQQIATISLAWMMAQCQPFIDFDLDYVHDQYEDVEDYYEKTDQRPRRWGFGKIFSGMEGVYALGGSKIRTPGRYTAVDPTNGRQTDAPLIETHEYIHPSVRARYKLRGPGLNDKGDYDCTAMQDWKLVVEAPEEAGTKRPNIFWKARDRPREGFVKILPEAPLWQLETELLSYDRETEEFVLRPSTVRQGRRKSGRKMATRAVSPGPRSPRSPQGRVYYEERIEEMRDSDMYPSRGRDDRKREEEMSPPSRRSSRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M3AZP5</accession>
    <name>M3AZP5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED4</name>
        <name evidence="10" type="ORF">SEPMUDRAFT_149501</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761108.1">
        <property type="nucleotide sequence ID" value="XM_016905592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AZP5"/>
    <dbReference type="STRING" id="692275.M3AZP5"/>
    <dbReference type="GeneID" id="27902729"/>
    <dbReference type="eggNOG" id="ENOG502SCD7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057381_0_0_1"/>
    <dbReference type="OMA" id="WPLEDKI"/>
    <dbReference type="OrthoDB" id="1929813at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019258">
        <property type="entry name" value="Mediator_Med4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13208">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13208:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10018">
        <property type="entry name" value="Med4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="119"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="222"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="222"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF12987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="285" mass="31738" checksum="1B0B5FDCF1A35EAB" modified="2013-05-01" version="1">MYAQFQASYQRVEASLQKLTDSIAAYNPSVSAADELVAADEAVKQNLDELVKHQQNYLRLQELRQTSNSLDETIKTTIRLLADTRKDIASIPATDSSADRRDVDIQELLTYAKYIAPTTVPPTYRKSPKDDSQSHSNVVESTAGSAGHTTQISNGLSTPPPQATTTAEDHNPAFIKSENIGLTTMEERDKAWLLPDPDVFQPWPTQDVMNSGALGDIQRMIERGEDPSTKLSKQEQAEADLKREAEEEANRQRKAEEERRAKEMFGAGTMQRRGTIVEAFNPDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M3AZR7</accession>
    <name>M3AZR7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Galactose oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_45108</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF13012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761133.1">
        <property type="nucleotide sequence ID" value="XM_016908951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AZR7"/>
    <dbReference type="STRING" id="692275.M3AZR7"/>
    <dbReference type="GeneID" id="27906088"/>
    <dbReference type="eggNOG" id="KOG0379">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030461_1_1_1"/>
    <dbReference type="OMA" id="PRDNDVH"/>
    <dbReference type="OrthoDB" id="10250130at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019760">
        <property type="term" value="P:glucosinolate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47435">
        <property type="entry name" value="KELCH REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_5G12780)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47435:SF4">
        <property type="entry name" value="KELCH REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_5G12780)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF13012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="333" mass="35587" checksum="50C1B19E5F25EAD3" modified="2013-05-01" version="1">MAPIPATWSKLAATGPLQRSSHNVNAIGNTIYVFGGELRPREPRDNNIHKISLDGTTSVQSLQAPHMAPSPRVGSASATIGDKIYFFSGRGGPEMAPVDEKGAVWSLDTRSNEWTLLSPSSPLFPDARSYHTIASDGADTIYVHAGCPEKGRLADLWAFSVSKKEWKQLSSAPDPPRGGTSIAWADGKLYRMNGFDGQKEVGGDLDVYDPANDSWSTVSFQANGKDGPGARSVAALVPVKVHGGTSLVTLFGESDPSSLGHQGAGKMLSDIWAYSLENKTWSEISIQSNEARPDARGWFDADVVALDEGEGVAISGGLGETNERLNDLWLLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M3AZW6</accession>
    <name>M3AZW6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_116135</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761193.1">
        <property type="nucleotide sequence ID" value="XM_016901231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AZW6"/>
    <dbReference type="STRING" id="692275.M3AZW6"/>
    <dbReference type="GeneID" id="27898368"/>
    <dbReference type="HOGENOM" id="CLU_1928918_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF13072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="131" mass="13788" checksum="F45FBBBEBDC70C81" modified="2013-05-01" version="1">MQDVDAKSQSEIKSILAFLPLAGTSSILSSHSNHELQTMNTELSVSGNNNSIVNELFSRLPTSSRGHAVAVIGKPSSTFFFLFFAFAGAQTANLASNPNTGTTVITVASQKSPAQFLYISLSFGFALAATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>M3B0T0</accession>
    <name>M3B0T0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_107396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761498.1">
        <property type="nucleotide sequence ID" value="XM_016900682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B0T0"/>
    <dbReference type="GeneID" id="27897819"/>
    <dbReference type="HOGENOM" id="CLU_1723481_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF13377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="152" mass="17000" checksum="82060859DD64F3D1" modified="2013-05-01" version="1">MYLASTRLTLVIQGPRRAEIKESACWKLWMLWLELELTCTEGRQGTTRPVPTSAHIVHTYDNTNKMQSESGSMQEVSLRDRFAPTSCQEAKPGTSTESQALLYGALARGQARPSGGFCIARRAMPNESCRQDRDGLLPECDRGGRPSRHQME</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M3B1H2</accession>
    <name>M3B1H2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein S21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_64780</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS21 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761768.1">
        <property type="nucleotide sequence ID" value="XM_016909693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B1H2"/>
    <dbReference type="STRING" id="692275.M3B1H2"/>
    <dbReference type="GeneID" id="27906830"/>
    <dbReference type="eggNOG" id="ENOG502SYGP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1759938_0_0_1"/>
    <dbReference type="OMA" id="HERWIKR"/>
    <dbReference type="OrthoDB" id="2501249at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070124">
        <property type="term" value="P:mitochondrial translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052837">
        <property type="entry name" value="Mitoribosomal_bS21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001911">
        <property type="entry name" value="Ribosomal_bS21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41237">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN MRP21, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41237:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS21M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01165">
        <property type="entry name" value="Ribosomal_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF13647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="148" mass="17176" checksum="7BF01951F36C75E0" modified="2013-05-01" version="1">MQGVANELEQAQASRRNSVDELLLRMANPNERKRTISGYKASDINDMFSGNGGQPVLTKEAEPVRLPPNVGRLVAVDEKRGIDVARAFRMMEVQCSRNRVKRSFALGRFYERPGLKRKRLKHERWIKRFKENFKGTVQMVQKMKKQGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M3B4F9</accession>
    <name>M3B4F9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_148328</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762813.1">
        <property type="nucleotide sequence ID" value="XM_016904854.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.M3B4F9"/>
    <dbReference type="GeneID" id="27901991"/>
    <dbReference type="eggNOG" id="KOG0065">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_35_0_1"/>
    <dbReference type="OMA" id="FCISNWA"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="575"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="607"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="650"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="685"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="715"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="823"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1254"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1288"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1325"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1365"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1389"/>
            <end position="1411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1520"/>
            <end position="1538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1550"/>
            <end position="1569"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="218"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="920"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="871"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="22"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="94"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="117"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="891"/>
            <end position="908"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF14692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1583" mass="177050" checksum="88B2EC5963B72106" modified="2013-05-01" version="1">MWGSGVDERKLNTSSHSLNQWHRGDPHSDSDRAHTPLHPTEEVEDGTRGQDGTWGESDVGGWTTESAMADYENLRRNLTTMERTRSKEAAQDGNALTRTTTAQSKRSQGGRRRASLLTMSTQADHTATRQPTREEAEAEVEAGPDDDDDEEEREEFELEKFMRDGHFERREDGKPQKKVGVIYKDLTVKGVGSTASFVRTLPDAILGTFGPDLWHIITRFVPALGRRSGETRTLLHGFSGCVRDGEMLLVLGRPGAGCTTFLKAISNNREPYAEVTGEVTYGGISADKQKKMYRGEVNYNPEDDIHFASLNVWQTFTFALYTKTKKKAQEDIPVIANALMRMFGISHTKYTLVGDEYTRGVSGGERKRVSIAETLASKSTVTCWDNSTRGLDASTALDYARSLRIMTDVTNRTTLVTLYQAGEGIYDVMDKVLVIDQGHEIYMGPASDAKQYFIDLGYHCPERQTTADFLTAVTDPVERQFREGYEAKAPKTPEELEKAFRASPAYQRVLEDMRDYEAYLKESGYADAERFENAVQTGKSKNVRKKSPYTVSFPRQVTACVKREFWLLWGDKTTLYTKVFIIISNGLIVGSLFYGQPENTEGAFSRGGALFFSILFLGWLQLTELMKAVSGRAVVARHKDYAYYRPSAVSIARVVADLPVIFVQVVLFGIIMYFMTNLTVTASRFFIYLLFVYVTTIMLTALYRLFASVSPEIDTAVRFSGIALNLLVIYTGYVIPKTQLLSKYIWFGWMYWINPIAYSFEAVLSNEFAGRTMQCAPEQLVPQGSGIDPAYQGCPIAGAQIGSTEVSGSDYIGTQYNYSRSHLWRNFGVVIAFTVLYILLAVIATELFDFSAGGGGALAFKKSKRAKNQVKEAAPADEEKAGIAEDSSSSTKKEAGMGESGDSDKENEALEQITKSESIFTWRDVEYTVPYLGGEKKLLNKVNGYAKPGVMVALMGASGAGKTTLLNTLAQRQSMGVVSGEMFVDGRELDGAFQRNTGFCLQGDLHDGTATIREALEFSAILRQDASVPRSEKIAYVDKIIDLLELNDLQDAIISSLGVEQRKRLTIGVELAAKPSLLLFLDEPTSGLDSQSAYSIVRFLKKLAHAGQAIVCTIHQPSSVLIQQFDMILALNPGGNTFYFGPVGENGKDVIKYFSERGVDCPPSKNVAEFILETAARPVQGKDGKKINWNQEWRNSQQAKDVIQEIEGLKLSRSKTQPEGKRKEQEKEYAAPVGVQCTELLKRTFKQYWRDPSYLYGKLFVSVVIGIFNGFTFWQLGNTIQDMQNRMFTAFLILTLPPTIVNAVVPKFFTNMALWQAREYPSRIYGWFAFCTAQVVAEIPAAIIGAVVYWVLWYFATGLPTEASVSGYVFLMTMLFFLFQASWGQWICAFAPSFTVISNVMPFFFVMFSLFNGVVRPYSMIPVFWRYWMYWVNPSTWWISGVLAATLHNIPVQCAESETAMFNPPPGQTCSQYAGSFAQSAGGYLLNGDATSTCMYCPYSSGDQYLSTLNIHASQKWRDFGIFLVFVFTNWFLVYFFIWSVRVKGWSFGMGYLFGGLGKLVSLITKPFARIFDKKKKNKESQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M3B804</accession>
    <name>M3B804_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_147680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764083.1">
        <property type="nucleotide sequence ID" value="XM_016904456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B804"/>
    <dbReference type="GeneID" id="27901593"/>
    <dbReference type="eggNOG" id="ENOG502RKY2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064995_0_0_1"/>
    <dbReference type="OMA" id="TTHEIFR"/>
    <dbReference type="OrthoDB" id="2823490at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF15962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="37430" checksum="1EBBD4CEDF67AC30" modified="2013-05-01" version="1">MASTTNPSPLLTLPRELRDLIMLEALTIRSPPPTRTRREIPPSGSDGQFYLWSERSNWKPLNLLAVNQQLRAEAQELTIQLQKAHKIRFVMDILASGYIYTPKWTLQNLALQPQSTLDLHCNLQIRSTEAFRSNHYGGGNTATTTEEPGHAFKTLLNFLSRFLFLGPTFLYHDDHHGNENLENNTTTPFSTKGPFFIHTLSIAVTFQDHYTPATHPDTVREIFRMMKALSKLDTAGKWIGSIRVEATWREPQGGQDCRWEREWDVKKKEEERKGGEEEEDREAADDLDDEVLRFREEDWAWMELHFGEAWRKRYFPRRSVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M3BST0</accession>
    <name>M3BST0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_136441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF09148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757269.1">
        <property type="nucleotide sequence ID" value="XM_016902778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BST0"/>
    <dbReference type="STRING" id="692275.M3BST0"/>
    <dbReference type="GeneID" id="27899915"/>
    <dbReference type="HOGENOM" id="CLU_1038877_0_0_1"/>
    <dbReference type="OMA" id="CLTERTG"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="268" mass="26960" checksum="75FCD19489B000E8" modified="2013-05-01" version="1">MPPADPVMPPTKPTGYGSGMPPADPVMPPTKPPGYGGSVPPPGPPPQPSMPPKSPVSPPPMTPPTYGMPPADPVMPPTKPTGYGSGMPPTDPVMPPTKPTGYGSGMPPADPVMPPTKPGYGSGGIGGPVPGPVGPQQFPPWGGSGSSSDHTITESDLLPHGYGSSLSPPSPFVPDGYGTGLVPSTPSTPTGFPGADFPPPPGFPGLIFDVDTDDESQSQDPFNPFAPNSSPLGPGDMFAGAKDDEADHNPMGGVVGSFIPKRAFEFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M3BVY6</accession>
    <name>M3BVY6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ASST-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_150405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759610.1">
        <property type="nucleotide sequence ID" value="XM_016906154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BVY6"/>
    <dbReference type="GeneID" id="27903291"/>
    <dbReference type="eggNOG" id="ENOG502QPU9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018249_0_1_1"/>
    <dbReference type="OMA" id="CWINDCL"/>
    <dbReference type="OrthoDB" id="5427350at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053143">
        <property type="entry name" value="Arylsulfate_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039535">
        <property type="entry name" value="ASST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340:SF5">
        <property type="entry name" value="ASST-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340">
        <property type="entry name" value="PQQ ENZYME REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="554"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF11489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="628" mass="70434" checksum="37F3020A22BA0C86" modified="2013-05-01" version="1">MAWTSSIRYLRAAVICLLITLSLLATLYLVHQLVLPVIAFLIPSLDPTFFDIGVFGAFPLEQYNSFHLGGPRARQLRWHPSCEAGLVLLTPNGPSVPRSGPMILDSNGKLVWMSDDFGAAANLKVQSYKGQDFLTLWSGEKAATSGKGVYFLLDQSYQVVKMVTAVGDGLHGDLHEFKITNNDTALLTVYDTTNANLTRMGMGRGEHGWVVNNMFQEVDIETGELLFQWSALDHFEPADTYMTNPFGGYRESIPFDFYHLNSVDKDSKGNYIISSRHFHHVMCISPTGETLWILGGRENQFEDLSDGQATNFKWQHDARWISEEEGILSLFDNSKAGPMHRDAPESRVLMIQLDLEKKTAKLVHAMTSLQGILASSQGSAQQLPGTKNMFVGWGSAAAYSEYSPDGELLCETHLGASWYYYFERMKSYRSTKTFVWHGRPQDPPQIAMNGNALSVSWNGATDVAFWSLEGTADLDVDGVEELRSKSEDSAVPHEQPFWTALDVIPKTGFEDTFDLSQLSLNKFFTRFRVAALDSDHNVLRVSESVTAVVTKTSYLMTSFKLSMIIGFLIGVRFVFKHFRSHGHFRYWNAPSTPAWMSWQGPSGRERSHSPAVYEWIQMKWAAAQSRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M3BYK4</accession>
    <name>M3BYK4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_148525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761267.1">
        <property type="nucleotide sequence ID" value="XM_016904975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BYK4"/>
    <dbReference type="GeneID" id="27902112"/>
    <dbReference type="HOGENOM" id="CLU_1595590_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF13146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="167" mass="18398" checksum="F8A2D1287B4B19F3" modified="2013-05-01" version="1">MQMRYLLAAQQRRAAMGGRCGGTTTSSRGECTNPQQQQQQQQQPQQASSRSMSNSGDSNSGSRINPMQQQQQQALRAMQGGNNSYTYGMHPLAGITTGGSGSGAGGYNSPTSIIGGRMLNPFMMQQQQQQRLQQQWLQQQWLQLQVLLAAAMYGDEGDDEDEDGYYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M3C0Q2</accession>
    <name>M3C0Q2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_65229</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762007.1">
        <property type="nucleotide sequence ID" value="XM_016909709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C0Q2"/>
    <dbReference type="STRING" id="692275.M3C0Q2"/>
    <dbReference type="GeneID" id="27906846"/>
    <dbReference type="eggNOG" id="KOG4628">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031409_1_0_1"/>
    <dbReference type="OMA" id="TKYKQWK"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16473">
        <property type="entry name" value="RING-H2_RNF103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000539">
        <property type="entry name" value="Ring finger domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051826">
        <property type="entry name" value="E3_ubiquitin-ligase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22765:SF434">
        <property type="entry name" value="GB|AAD18119.1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22765">
        <property type="entry name" value="RING FINGER AND PROTEASE ASSOCIATED DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="240"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="74"/>
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    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="117"/>
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    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="154"/>
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    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="293"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="341"/>
            <end position="422"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="2">
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            <begin position="1"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="170"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="353"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF13886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="422" mass="45994" checksum="1D5A03599C56921D" modified="2013-05-01" version="1">MATTTTSSLPTATDSAGGGANQDHSGGPTSSPLLFFVALGFGVVFTNLWIIVGVKYCFRYNQRNRQARALNENGEPIDLAQMPGQRRRRKEKKLMSMEDVNERFPLIKYKTWRSSREAQGLPAEGGVTAPPSRAGSLRDEDGVIDAFGKQSIETASPPTALSMARESLVSATADAPRPEAAASTDHFQEKTPTIEELEHARKNSVDRTNSAATEVDEVDEDDPIATAAPPEMLAAPGDTCAICLDTLDDDDDVRGLTCGHAFHGSCVDPWLTSRRACCPLCKADYYVPKVRPEEETTTATSGRRGRNGALPTEPPPTWRHGMPFRPRMLFAGHPRIFISDAARTGHPSPAALERARRERDVQRAPPVQPPADATHTTRTWRSRIPTVSLPRFGRRPRASPTGHGAVEEVNVTASDLEAGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M3C1A1</accession>
    <name>M3C1A1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="15">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SEPMUDRAFT_62102</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 20">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="15"/>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762197.1">
        <property type="nucleotide sequence ID" value="XM_016909586.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.M3C1A1"/>
    <dbReference type="GeneID" id="27906723"/>
    <dbReference type="eggNOG" id="KOG0260">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000487_3_0_1"/>
    <dbReference type="OMA" id="KPCMGIV"/>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140463">
        <property type="term" value="F:chromatin-protein adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0180034">
        <property type="term" value="P:co-transcriptional lncRNA 3' end processing, cleavage and polyadenylation pathway"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:intracellular phosphate ion homeostasis"/>
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        <property type="term" value="P:termination of RNA polymerase II transcription"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0006368">
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        <property type="project" value="EnsemblFungi"/>
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    </dbReference>
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        <property type="term" value="P:translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02584">
        <property type="entry name" value="RNAP_II_Rpb1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNAP_II_RPB1_N"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000684">
        <property type="entry name" value="RNA_pol_II_repeat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR007073">
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    </dbReference>
    <dbReference type="InterPro" id="IPR038593">
        <property type="entry name" value="RNA_pol_Rpb1_7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006336">
        <property type="entry name" value="PRK08566.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF37">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1"/>
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    </dbReference>
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        <property type="entry name" value="RNA_POL_II_REPEAT"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 15" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="12 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="17">
        <location>
            <begin position="242"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
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            <begin position="146"/>
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            <begin position="1576"/>
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        <location>
            <begin position="149"/>
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            <begin position="196"/>
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        <location>
            <begin position="1581"/>
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        <location>
            <begin position="1609"/>
            <end position="1634"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1643"/>
            <end position="1688"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1696"/>
            <end position="1716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1724"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU004279"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMF14076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1780" mass="194744" checksum="6A8E8AE85B004163" modified="2013-05-01" version="1">MSTFAHSDAPLKTVKEIQFGLFSPEEIKNMSVCHIEYPETMDEQRNRPRERGLNDPKLGTIDRSQMCATCGESQQECPGHFGHIELAVPVYHVGYITKIKKILESVCNNCGKLLEDERNPTFALAIKLRDPKRRFEAVTRLCKPKMDCQTDEPSDEDGQFGDDPKKPKLAGHGGCGNMQPTIRKDGLKLIGTWKMPKNEDTGEDNSPEKKPITPTDALRVFRNISDEDLYRLGLNVDYARPEWMILTVLPVPPPAVRPSISVDGTSQGMRSEDDLTYKLSDIIRANSNVRRAEQEGSPAHITEEFTQLLQYHVATYMDNDIAGLPKSIQKSGRPLKAIRARLKSKEGRLRGNLMGKRVDFSARTVITGDPNLDLDQVGVPRSTARVLTFPERVTPYNIHKLSELVRNGPSEHPGAKHIIREDGSRIDLRYHKRAGEIQLQNGWIVERHIVDGDYIIFNRQPSLHKESMMGHRVKVMPYSTFRLNLSVTSPYNADFDGDEMNLHVPQSHETRSEVANLCAVPHNIVSPQKNGPLMGIVQDTMAGIYMMTKRDTMMDYEQVMNIMLWVPGWDGIVPQPAILKPVPRWTGKQIMSMGLPSGLNIMKLGDDEDHISLAEADSSVLVQNGELVWGRLTKKLVGASGGGIVHLIFNDRGTDATVEFFNAAQRIVCYWLLHNGFSVGIGDTIPDADMVLAIEQNIVKEKATVDGYMREVQSDEMEALPGMTIRETFESQTKAALDNARNNAGDAAYKGMKPCNNVGVMVKGGSKGSTTNVSQMTAAVGQQSLEGKRLPFGFKDRVLPHFPKDDYSPASRGFVENSYLRGLTPQEFFFHAMGGREGLIDTAVKTAETGYIQRRLVKALEEIMIKYDGTVRNSLGDILQFVYGEDGLDATFIEGQALSIIKQSHSAFDKKYKIDVINPSSKDQTLSSNVLEMAGELQGDVEVQELFDQEYEAIKNDRIKIRQGLDDPSDQRFLPLNVSRMIQNARDKFKITDNSKSDLDPRDAIPKVAALLDRLKIIRGDDALTREADVNATLLCKALFRSRLAFKRVVNEDKLSKLAFDNILGDIENRFLRALVSPGEMVGVLAAQSIGEPATQMTLNTFHLAGVTAKTTTKGVPRLKEILNVADNIKTPNMRVFQEPHATTKQESAKLLRSKVEFTSLRGVTDAAEIYYDPDVQSTVIEEDRDMVESYFIIPEEGENPDAQSKWMLRFVLGRRQLLDKGLTVTNVAEKIRETYPKDVAVIFSDDNSDEMVVRVRMTNQADKEEELGESSEDDTLKQLSEHMLDNVVLRGVQGVRRVFVSKDLSMIEEADGKLVKSKNDKACEEWYLDTDGINLKDVLAVEGVDSTRTTCNHFQSTMRVFGIEAVRASLMRELKDVLTNDGSYVNHRHMAILCDVMCARGELMAVTRHGINRADTGALMRCSFEETVEILFEAASSGELDDCRGVSENIILGQLAPSGTGEFDVLLDNEMLKTVPPQMVLPGRAGVGAGAMSPMADGAMTPYDMGSPMSESGFTGPDYGASFSPIINPGQDEGGGLTAYGGFDGGMSPYRGGMSPGYAPQSPFSAGMSPASPGYGGGYSPSSPSFGGGFSPQSPGAALTSPAYQMGSPAGYSPASPAYSPTSPNYSPSSPAWSGGGGSKVSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPNYSPSSPNFSPSNQAGGAKYSPTSPQYSPKSPAYSPTSPTYNGGGRAASSTSPGSPSYSPTSPVYSPTSPQQNGTSPGSNGTSPTSPQYSPTSPQYSPASPKDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>M3C269</accession>
    <name>M3C269_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="15 20">Inosine-5'-monophosphate dehydrogenase</fullName>
            <shortName evidence="15">IMP dehydrogenase</shortName>
            <shortName evidence="15">IMPD</shortName>
            <shortName evidence="15">IMPDH</shortName>
            <ecNumber evidence="15 20">1.1.1.205</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">SEPMUDRAFT_41062</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Part of the gene cluster that mediates the biosynthesis of mycophenolic acid (MPA), the first isolated antibiotic natural product in the world. Does not play a role in the biosynthesis of MPA, but is involved in self resistance to MPA, since MPA acts as an inhibitor of IMP dehydrogenases.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 15 20">
            <text>IMP + NAD(+) + H2O = XMP + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="15">Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15 20">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homotetramer. Seems to be able to form heterotetramers composed from more than 1 of the 3 IMPDH gene products (IMD2-4).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15 19">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="15 20"/>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762492.1">
        <property type="nucleotide sequence ID" value="XM_016908810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C269"/>
    <dbReference type="STRING" id="692275.M3C269"/>
    <dbReference type="GeneID" id="27905947"/>
    <dbReference type="eggNOG" id="KOG2550">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022552_2_1_1"/>
    <dbReference type="OMA" id="MGYCGAK"/>
    <dbReference type="OrthoDB" id="416622at2759"/>
    <dbReference type="UniPathway" id="UPA00601">
        <property type="reaction ID" value="UER00295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04601">
        <property type="entry name" value="CBS_pair_IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000007">
        <property type="entry name" value="Chromosome 19 SCAF14664, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01964">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01302">
        <property type="entry name" value="IMP_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911:SF111">
        <property type="entry name" value="INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="INOSINE-5-MONOPHOSPHATE DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01240">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 18" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 15 20" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="5 15 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 15 16" id="KW-0520">NAD</keyword>
    <keyword evidence="9 15 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 15 17" id="KW-0630">Potassium</keyword>
    <keyword evidence="7 15 20" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="22">
        <location>
            <begin position="139"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="22">
        <location>
            <begin position="202"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="15">
        <location>
            <position position="353"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="466"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15 16">
        <location>
            <begin position="296"/>
            <end position="298"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15 16">
        <location>
            <begin position="346"/>
            <end position="348"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15 17">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15 17">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15 17">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="386"/>
            <end position="388"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="409"/>
            <end position="410"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="434"/>
            <end position="438"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="478"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="533"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00062187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU003928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EMF14371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="552" mass="58384" checksum="86B7DE773AAF4CF7" modified="2013-05-01" version="1">MASLSLNGGANGHASDSEERFEDPAKALEILKSSYGRKDGISVHELMDETKTGGLTYNDFLMLPGYIGFPASDVDLTSKLTRNITLKTPFTSSPMDTVTEHNMAIHMALLGGVGVIHHNCSVEEQAEMVMKVKRFENGFITDPIVLSPKATVADAIALKEKWGFGGFPVTESGQLKSKLIGIVTPRDTQFHADLDSPVTDIMSTELVTAQQGVSLKEANAILSKSKKGKLPIVDNSGNLISLLSRSDLMKNLNYPLATKVPGTKQLLSAAAIGTRPADKERLAALVEAGLDVVILDSSQGNSMYQIEMIRWIKQNYPKLDVIGGNVVTRDQAASLIAAGVDGLRIGMGAGSACITQEVMAVGRPQATSVFRVTEFASRFGIPCIADGGIQNVGHIVKAIALGASTIMMGGLLAATTESPGAYVVGPDGQLRKTYRGMGSIDAMEDKKAGGSGDKANNTAKNAGTARYFSEGDKVLVAQGVSGSVLDRGSVTKFLPYLMAGVQHSLQDTGITSVEALQKGVRAGEVRFEFRTASAQAEGNVHGMVGVEKKLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M3C409</accession>
    <name>M3C409_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_105298</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF14981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763102.1">
        <property type="nucleotide sequence ID" value="XM_016900571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C409"/>
    <dbReference type="STRING" id="692275.M3C409"/>
    <dbReference type="GeneID" id="27897708"/>
    <dbReference type="HOGENOM" id="CLU_1489893_0_0_1"/>
    <dbReference type="OMA" id="VICADHN"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032273" evidence="2">
        <location>
            <begin position="30"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF14981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="181" mass="18826" checksum="C6E1BF80A261AE1B" modified="2013-05-01" version="1">MSQPTLPRLLLLLLLLLLHLLIIPSAISARPLTQHKSTPSSLKDESPISIDGLCGSHSNNNQKTTCLHSPFGDSCSKWGFCGSFYEKEYSGIGCQVDFGVCNSEFATLTDDAAESSTTSLSTSSSFSTSTTTSTPGIIIIPATTTFVSVVVSTSVSGSFTPVQTLTGMVGFCGVAGSNCAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M3C6V4</accession>
    <name>M3C6V4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ER membrane protein complex subunit 7 beta-sandwich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_139601</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764082.1">
        <property type="nucleotide sequence ID" value="XM_016902908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C6V4"/>
    <dbReference type="STRING" id="692275.M3C6V4"/>
    <dbReference type="GeneID" id="27900045"/>
    <dbReference type="eggNOG" id="KOG3306">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073620_0_0_1"/>
    <dbReference type="OMA" id="FTFGMPK"/>
    <dbReference type="OrthoDB" id="27095at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019008">
        <property type="entry name" value="Beta_sandwich_EMC7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039163">
        <property type="entry name" value="EMC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13605">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13605:SF4">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09430">
        <property type="entry name" value="EMC7_beta-sandw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032564" description="ER membrane protein complex subunit 7 beta-sandwich domain-containing protein" evidence="7">
        <location>
            <begin position="20"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="ER membrane protein complex subunit 7 beta-sandwich" evidence="8">
        <location>
            <begin position="53"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF15961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="232" mass="25100" checksum="FEFEA47D57FBB55F" modified="2013-05-01" version="1">MASIRNALVVVACAAFASAARLTVSIPPSQLLPNPSTLPSSSHAILLGPPGVLYDVPLRRDNTFLFSDLPDASYLLTIHSRDYFFPPLRVDVAPYAGEGGSQNISAWATFRGNEWDNKGQPFGTGRDELRIEVRAGAEKQYYQERGGFSILSFLKSPMILMGLASVVLIFGMPYLMDNMDPETREEFEEISKKSPLTGSAGAAVQMQNFDLAGFLAGTTKSSEDAQAGGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>M3C742</accession>
    <name>M3C742_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">DNA ligase</fullName>
            <ecNumber evidence="16">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">SEPMUDRAFT_147745</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">DNA ligase involved in DNA non-homologous end joining (NHEJ); required for double-strand break (DSB) repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 16">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="16"/>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF16071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764192.1">
        <property type="nucleotide sequence ID" value="XM_016904498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C742"/>
    <dbReference type="STRING" id="692275.M3C742"/>
    <dbReference type="GeneID" id="27901635"/>
    <dbReference type="eggNOG" id="KOG0966">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004844_1_1_1"/>
    <dbReference type="OMA" id="IMLQHRT"/>
    <dbReference type="OrthoDB" id="151490at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032807">
        <property type="term" value="C:DNA ligase IV complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07903">
        <property type="entry name" value="Adenylation_DNA_ligase_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17722">
        <property type="entry name" value="BRCT_DNA_ligase_IV_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07968">
        <property type="entry name" value="OBF_DNA_ligase_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000234">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Adenylation_DNA_ligase_IV"/>
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        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
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        <property type="entry name" value="DNA LIGASE 4"/>
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        <property type="entry name" value="DNA_LIGASE_A1"/>
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        <property type="entry name" value="DNA_LIGASE_A3"/>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="8 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 16" id="KW-0233">DNA recombination</keyword>
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    <keyword evidence="4 16 21" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="19">
        <location>
            <begin position="306"/>
            <end position="431"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="564"/>
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50172"/>
        </source>
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        <source>
            <dbReference type="EMBL" id="EMF16071.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
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    </evidence>
    <sequence length="859" mass="98456" checksum="DB391EBD327B25EB" modified="2013-05-01" version="1">MYGLKEMTLGKMLIRILKIDKNSDDGYSLTHWKLPGVKSTSATTGDFAGRCFDAISKRPMRSEPGDMSVAEVNERLDRLSVAQKEENQRPILEEFYSRMNAEELMWLIRIILRQMKVGATEKTFFELWHPDADNLFNISSSLRRVCWELHDKKVRLEGDSRGISLMQCFQPQLAAFQMKTFEQMIARMDPTDEDPIFWIEEKLDGERIQLHMIEDDEQPGGVRFCFWSRKAKDYTYLYGSGFQDDDAALTRHIKDAFNSGVRNIILDGEMITWDAQEDCIVGFGTLKTAAIEQQQNPFAGGHRPLFRVFDCLYLNDKPLTQYTLRNRRAALEASITDVHRRLEIHKYLECKTAADVELELRQAVAEASEGLVMKNPRSEYRLNERNDDWIKVKPEYMTEFGESLDCIVVGGYFGSGKRGGHHSSFLCGLYLPSAWRAGLEPHAHPQKTWSFFKVGGGFSASDYAQIRHETDGKWKDWDRKKPPTEWIELGGGDRQHEKPDQWIKPEDSVVVSVKAASVEQSDQFRTKFTLRFPRFKKLRTDKSWAQALSYDEFMTLKYNAEDQQHDKKLKVDESRKQRTTKRQKRELVIQGQECDTQTAYAGPATQVFEGLAFCIMTEAGKPLKKSKAELEQMVKANGGQIVAAPNDPDTILIADRNLVRVASIKKNNNRNIIRPCWLLDCIKQSELDAGRPAHLLPLEPHHLEFTHTADEGKFDDNVDEFGDSYARDVTAQDLLALFKEMPTKLEDDFEPSGVLQQFNEHGHGLDAVTALMFFGTIAFFEDARPETKRIYSFAGGMIADSLQERNLTHVVVPAGSDDVAKIRRAISSKTQQPRIVSEDWVRESWAEETRLDEERMFIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M3C786</accession>
    <name>M3C786_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_147777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EMF16121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016904519.1"/>
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    <dbReference type="HOGENOM" id="CLU_1839989_0_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF16121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="140" mass="15080" checksum="0756FE74BD2A236A" modified="2013-05-01" version="1" fragment="single">MNLPKIITSIMPRFKRSKTTETMPQSELIEPLPIARHDCSATGADCIPGPSSPSNRNRSSVSGYHYDATTGVAQFREPRESESSGPFSPYGSSTNNGRISDYGTPGTTPDRSEFAPRPGVLPSTSSCGESLPWNRGSQNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M3C8G8</accession>
    <name>M3C8G8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Outer spore wall protein RRT8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_152442</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF08185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016907448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C8G8"/>
    <dbReference type="STRING" id="692275.M3C8G8"/>
    <dbReference type="GeneID" id="27904585"/>
    <dbReference type="eggNOG" id="ENOG502QVX4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062645_0_0_1"/>
    <dbReference type="OMA" id="GRYFQLK"/>
    <dbReference type="OrthoDB" id="10012223at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005619">
        <property type="term" value="C:ascospore wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005628">
        <property type="term" value="C:prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059112">
        <property type="entry name" value="CysZ/EI24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052786">
        <property type="entry name" value="Spore_wall_assembly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN LDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292:SF2">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN LDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07264">
        <property type="entry name" value="EI24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF08185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="281" mass="30388" checksum="31EA74A39ABFD8A2" modified="2013-05-01" version="1">MADKIKETAKQEISATAKQASDAAKSGAYLYPLQGIFYFWTHKSLWKPFLSRLVPTMGLGAAVTTAMFFFTYLPQLGVLFFTSGPLAVASTVVLVLSESSTLTMVLAKTLLIEDALIDTFDGTLVAKGHTGLVEQQRQVKGSSFGDSVQRLGKLATKPFQKFTPAALARYLISLPLNFIPVVGTVMFVLLQARNRGPATHARYFQLKGMNAAQKERYVEARKGSYTAFGVPAVLLEMVPLAGILFAFTNTCGAALMAADFEQHGDTSPELRDKASSSKKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M3CAM6</accession>
    <name>M3CAM6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CBS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_151796</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757006.1">
        <property type="nucleotide sequence ID" value="XM_016907049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CAM6"/>
    <dbReference type="STRING" id="692275.M3CAM6"/>
    <dbReference type="GeneID" id="27904186"/>
    <dbReference type="eggNOG" id="KOG1764">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024459_0_0_1"/>
    <dbReference type="OMA" id="DWTQISI"/>
    <dbReference type="OrthoDB" id="449052at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02205">
        <property type="entry name" value="CBS_pair_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050511">
        <property type="entry name" value="AMPK_gamma/SDS23_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780:SF36">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="305"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="454"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="509"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="36"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="527"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF08885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="585" mass="63307" checksum="CBFA806E6C81D3EE" modified="2013-05-01" version="1">MAESEPEAPRTATAPASRGLLAPSSPPPPPPHPPLDSKSSPIIRPQSITASSSAPSTTPTPAQTPRLENVSPSVSKRSSFADNLNLRNHPVSPRQHTARTHSFSGPVLTELLMQPSHKAHGRDERFKGRDWRTIQVQEIIEPAEARFVELDSSIEDTTKLLIRSGSPNVVLVRESRKTKTVLSTFDYSDLNAYLLLVLGLSQPDELAARIADRARRGEVIPLKDVTDHLGPREEPVFTMHTATLLQAMELLGAGHHRVIVHKEGTSEAVGVLTQLRLVQFFWDNHQNFTATENLYSMTLKELELGAKEVLAINGDKPVADALRLMHAEGITSLPVLDNHRNVVGNISHVDVRLLTDTSAIPLLHSSCIHFIGVILSERGMFDGKDSYPVFHITPFSTLAHTVAKLCATRSHRMWVVDAPSPSTSVPPSPGMKHVIPSSAMHSSGLEHNTPITTPVRAGGGTDSMTPGPPYTSTNPAISIGAAQMPGASMSGRLSGVVSLTDILNLFARASGLSPGDPEETRRRRRQSSSSSVRPSMDSVRPSMDSVRPSVEGLRISQSREREMSSSTEMGRAGEGGNASRDRVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M3CB69</accession>
    <name>M3CB69_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Prenylcysteine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_151927</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prenylcysteine oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF09090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757211.1">
        <property type="nucleotide sequence ID" value="XM_016907131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CB69"/>
    <dbReference type="STRING" id="692275.M3CB69"/>
    <dbReference type="GeneID" id="27904268"/>
    <dbReference type="eggNOG" id="ENOG502QSHJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021176_0_0_1"/>
    <dbReference type="OMA" id="SIGIWDG"/>
    <dbReference type="OrthoDB" id="437369at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001735">
        <property type="term" value="F:prenylcysteine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030327">
        <property type="term" value="P:prenylated protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030328">
        <property type="term" value="P:prenylcysteine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010795">
        <property type="entry name" value="Prenylcys_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017046">
        <property type="entry name" value="Prenylcysteine_Oxase1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15944">
        <property type="entry name" value="FARNESYLCYSTEINE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15944:SF0">
        <property type="entry name" value="PRENYLCYSTEINE LYASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07156">
        <property type="entry name" value="Prenylcys_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036292">
        <property type="entry name" value="Prenylcysteine_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004031751" evidence="9">
        <location>
            <begin position="19"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Prenylcysteine lyase" evidence="10">
        <location>
            <begin position="172"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="535"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF09090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="562" mass="61570" checksum="94E93AFDD1D08A89" modified="2013-05-01" version="1">MKFTTAGCSLLAVSLSTALQRDQQPLALHQDVTSEKPVEVAIIGAGAAGASAAYYLAQYAHNASVPLNITIFEANSYIGGRSTTVNAYDLTDDDLADLRALVSNLEDEYEYSVELGASIFVSINKILKDAVDAFNLTIKSGDDNPKGHTGSDLGIWDGESFIVELDGSLNGYWDVAKLLWKYGLAPVKTQRLMKTVVGKFMRMYEEPIFPFTAGLTAAAQAVGLTAVTAATGEQYMRENGIKGAFGREIVQASTRVNYAQNLEFIHGLEAMVCMATDGAVAVEGGNWRIFQNMIEASGAHVLLGERVSEIIELDVGGHAISTSSQQVWRGDHIIIAGPYQYTNITSSMLDEKHAFHKPDPIPYVELHVTLFTSPHLLSPTFFNLPPDKAVPQVVLTSLPDGEPAGSGQESVGKPGFFSISLLRSIVNPKTGADEYLYKIFSPESPTSAWLEALLGIKPEDSNPNRNSEDITWLYRKVWNSYPYEYPRMTFESTKLKDGIWYTGGMDSFISTMETNALMGKNVARLIVDEEKLMKQRQSNSGLGEEEHERVQGMTQMKGKLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M3CCW9</accession>
    <name>M3CCW9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">L-serine ammonia-lyase</fullName>
            <ecNumber evidence="5">4.3.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_71512</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-serine = pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.17" evidence="5"/>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758383.1">
        <property type="nucleotide sequence ID" value="XM_016909942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CCW9"/>
    <dbReference type="STRING" id="692275.M3CCW9"/>
    <dbReference type="GeneID" id="27907079"/>
    <dbReference type="eggNOG" id="KOG1250">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021152_3_1_1"/>
    <dbReference type="OMA" id="DGWVNIH"/>
    <dbReference type="OrthoDB" id="7773036at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:threonine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006565">
        <property type="term" value="P:L-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000040">
        <property type="entry name" value="L-serine dehydratase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF2">
        <property type="entry name" value="CATABOLIC L-SERINE_THREONINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="12">
        <location>
            <begin position="24"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF10262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="368" mass="39104" checksum="FA6F631C52DDC458" modified="2013-05-01" version="1">MPDSPINPHTTHLHPSSPPSDKPWRETPLIESPKLSLAAGCRILLKLENLQPSGSFKIRGLGNLVLKSSRSTSTSASASSTSKPTHFFSSSGGNAGLAAVLAAQFVQRPCTVVVPLSTSAMMIEKIRQAGAREVVQEGKSWKECDAYLREVVMARETGEEEIGVYVPPFDHPDIWEGNGSLVEEIGRQMGVEKGGKGPDWIICSVGGGGLFCGIIEGVQKAGWEKTTKVLAVETSGADSLNQSLRAGKPITLEAITSIATSLGAVRVGNHTFDLAHHGVQNGTVKTTVLTDAEAALGSWKLLQDENETYLVEAACGVNIALCYGGRLEQALGRKPRPDETVVIVVCGGSNVSRDMVEGWKGEYGLDML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>M3CE68</accession>
    <name>M3CE68_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="27">Fatty acid synthase subunit beta</fullName>
            <ecNumber evidence="5">1.3.1.9</ecNumber>
            <ecNumber evidence="7">2.3.1.38</ecNumber>
            <ecNumber evidence="8">2.3.1.39</ecNumber>
            <ecNumber evidence="4">2.3.1.86</ecNumber>
            <ecNumber evidence="3">3.1.2.14</ecNumber>
            <ecNumber evidence="6">4.2.1.59</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="31" type="ORF">SEPMUDRAFT_150300</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="31 32" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="31 32">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="26">Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. The beta subunit contains domains for: [acyl-carrier-protein] acetyltransferase and malonyltransferase, S-acyl fatty acid synthase thioesterase, enoyl-[acyl-carrier-protein] reductase, and 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>(9Z)-octadecenoyl-[ACP] + H2O = (9Z)-octadecenoate + holo-[ACP] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15057"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9924"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78783"/>
            <dbReference type="EC" id="3.1.2.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:13097"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="4.2.1.59"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>a 2,3-saturated acyl-[ACP] + NAD(+) = a (2E)-enoyl-[ACP] + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10240"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>acetyl-CoA + n malonyl-CoA + 2n NADPH + 4n H(+) = a long-chain-acyl-CoA + n CoA + n CO2 + 2n NADP(+).</text>
            <dbReference type="EC" id="2.3.1.86"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>holo-[ACP] + acetyl-CoA = acetyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41788"/>
            <dbReference type="Rhea" id="RHEA-COMP:9621"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78446"/>
            <dbReference type="EC" id="2.3.1.38"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>holo-[ACP] + malonyl-CoA = malonyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="EC" id="2.3.1.39"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="20">[Alpha(6)beta(6)] hexamers of two multifunctional subunits (alpha and beta).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 28">Belongs to the fungal fatty acid synthetase subunit beta family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.9" evidence="5"/>
    <dbReference type="EC" id="2.3.1.38" evidence="7"/>
    <dbReference type="EC" id="2.3.1.39" evidence="8"/>
    <dbReference type="EC" id="2.3.1.86" evidence="4"/>
    <dbReference type="EC" id="3.1.2.14" evidence="3"/>
    <dbReference type="EC" id="4.2.1.59" evidence="6"/>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759462.1">
        <property type="nucleotide sequence ID" value="XM_016906075.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.M3CE68"/>
    <dbReference type="GeneID" id="27903212"/>
    <dbReference type="eggNOG" id="ENOG502QQJX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000114_5_0_1"/>
    <dbReference type="OMA" id="HFMDNYG"/>
    <dbReference type="OrthoDB" id="5417908at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005835">
        <property type="term" value="C:fatty acid synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019171">
        <property type="term" value="F:(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004313">
        <property type="term" value="F:[acyl-carrier-protein] S-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004318">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016297">
        <property type="term" value="F:fatty acyl-[ACP] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004321">
        <property type="term" value="F:fatty-acyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03447">
        <property type="entry name" value="FAS_MaoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.120:FF:000001">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.70:FF:000001">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000017">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000078">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.100:FF:000001">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000015">
        <property type="entry name" value="Fatty acid synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3330:FF:000001">
        <property type="entry name" value="Fatty acid synthase subunit beta dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.366.10:FF:000003">
        <property type="entry name" value="Fatty acid synthase subunit beta dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1400">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039569">
        <property type="entry name" value="FAS1-like_DH_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016452">
        <property type="entry name" value="Fas1/AflB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013565">
        <property type="entry name" value="Fas1/AflB-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041099">
        <property type="entry name" value="FAS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040883">
        <property type="entry name" value="FAS_meander"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003965">
        <property type="entry name" value="Fatty_acid_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050830">
        <property type="entry name" value="Fungal_FAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982:SF21">
        <property type="entry name" value="FATTY ACID SYNTHASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982">
        <property type="entry name" value="MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08354">
        <property type="entry name" value="Fas1-AflB-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13452">
        <property type="entry name" value="FAS1_DH_region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22235">
        <property type="entry name" value="FAS1_thioest_ins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17951">
        <property type="entry name" value="FAS_meander"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17828">
        <property type="entry name" value="FAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005562">
        <property type="entry name" value="FAS_yeast_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01483">
        <property type="entry name" value="FASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="11 28" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="18" id="KW-0456">Lyase</keyword>
    <keyword evidence="19" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="15 28" id="KW-0520">NAD</keyword>
    <keyword evidence="13 28" id="KW-0521">NADP</keyword>
    <keyword evidence="14 28" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 28" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Malonyl-CoA:ACP transacylase (MAT)" evidence="30">
        <location>
            <begin position="1691"/>
            <end position="2012"/>
        </location>
    </feature>
    <feature type="active site" description="For acetyltransferase activity" evidence="29">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <feature type="active site" description="For malonyltransferase activity" evidence="29">
        <location>
            <position position="1835"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00033756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00048572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00048835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00058855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00068309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="PIRNR" id="PIRNR005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="PIRSR" id="PIRSR005562-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="EMBL" id="EMF11341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="2096" mass="233048" checksum="F4BCC87269B21418" modified="2013-05-01" version="1">MYGSGSQTGVSTPRSQAVSRPLTLSHGSLEYTFLIPTALHFNATQLKDQFLSTLPEATEELAQDDEPSSTTELVARYIGFVAKEVDEGDDPELFTEVLKLVLTEFERTFLRGNEVHAIASHLPGIYEKKLVTVQAYYAARAAIKRPIRSHESALLREAADENAYVYAVFGGQGNIEEYFDELREIYNTYPSLVRDFLNVAAQHLQFMSRDERAFKSYAKGLDIMRWLDNKDSQPDTDYLVSAPVSFPLIGLTQLAHYVVTCRVLGTHPGHVRDRFAGASGHSQGVVTAAAIAASSNWETFDKQARNALTILFWIGARSQQAYPRTSLAPNVLQDSIDAGEGSPTPMLTVRDLSRETIEKLIKQTNEHLPEDRHIGISLVNSARNFVVTGPPMSLYGLNLQLRKIKAPTGLDQARIPFTERKVRFVNRFLPITAPFHSPYLAGAMKHLESDLAEIKIEASELGIPVFNTYTGGDLREEEEGQSITLALVKMICQDQVLWEKATVMPNATHILDFGPGGISGLGVLTNRNKDGTGVRVILAGTMDGTNPEVGYKPEIFDRDAEHAVKYAVDWVKEFGPKLVKTSAGQTFVDTKMSRMLGLPPVMVAGMTPCTVPTDFVAATMRAGYEIELAGGGYYNDKSMTEAIARIEKEIPAGRGITINLIYINPRAMGWQIPMIGRLRAEGVPIEGLTIGAGVPSVEVANEYIETLGIKHISFKPGSSEAIQAVINIAKANPGFPVMMQWTGGRGGGHHSFEDFHQPILSMYTRIRRCQNLVLIAGSGFGGAEDTYPYLTGQWAKKFGYPPMPFDGVLFGSRVMVAKEAHTSPAAKQAIVDAPGLEDHEWEKTYKGTAGGVITVRSEMGEPIHKLATRGVLFWAEMDQKIFSLDKAKRIPELKKHRDYIIQKLNDDFQKPWFGRNKAGDCVDLEDMTYGEVLRRMVDLMYIKHQKRWIDKSLTRLTGDFIRRIEERFANTNGSGSIIQNYTELDDPFGTVNKVLESYPEADVQLINAQDVQHFLLLCQRRGQKPVPFVPCLDETFEFFFKKDSLWQSEDLEAVVDQDVGRVAILQGPMAVKYSTIVDEPIKDILDGVHEGHIKFLTRDLYGGDVKKIPQIEYFGGKLIEASAELSNHEGLTVNETEHKILYRLSVVSGTTLPPVENWIQLLAGRAHTWRHAFFTADVFVQGQRYQTNPTQRIFAPTPGMVVEIQHPNDPMRTTITVKEPSHGNEYVHTIHVARDANGEITVNMIEGRTATGRPVALPLRFTYHPETGYAPIREVMDHRNDRIKEFYYKIWFGDEECPFDVDVTSRFDGGRATVTSEAINDFVHAVGNTGEAFVERPGKEVFAPMDFAIVVGWKAITKPIFPRTIDGDLLKLVHLSNGFRMIPGAAPLKKGDVLDTTAQVNAVINQASGKMVEVCGTITRDGKPVMEVTSQFLYRGSYTDYHNTFQRKVETPMQVHLGSSKDVAVLQSKEWFKIENEDVDLLNQTLVFRLNSILRYKNQTVFSSVQTEGTVELELPSKEIITVASVEYEAGTSYGNPVLDYLTRNGSALDQPVNFENPIPLSGKSPLVLKAPSSNETYARVSGDYNPIHVSRVFSQYAGLPGTITHGMYSSAAVRSLVETWAAENNVGRVRSFHASLVGMVLPDDTIEVKLQHVGMVAGRKIIKIEAQKAETEDKVLLAEAEVEQPVSAYVFTGQGSQEQGMGMDLYGSSEVAKEVWDRADKHFMDNYGFAITNIVKNNPKELTIHFGGARGKAIRKNYIDMTFETVGADGAIKSEKIFKEIDESTTSYTYRSPTGLLSATQFTQPALTLMEKASFEDMLSKGLVQRDSSFAGHSLGEYSALAALAEVMPIESLVSVVFYRGLTMQVAVERDEAGRSNYSMCAVNPSRISKTFNEQALQYVVENISLTTDWLLEIVNLNVQNQQYVCAGDLRALDTLTGVLNYLKAQKIDIQELMQSLSLEEVKAHLVEIIQGCAKQTEAKPKPLDLQRGFATIPLKGIDVPFHSTFLRSGVKPFRSFLLKKIHKTSIDPSKLVGKYIPNVTAKPFALTKEYFQDVYDLTKSPRIGNILDNWEKYESDEPHLQRPRAGSVAVPSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M3CEJ4</accession>
    <name>M3CEJ4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_150393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759587.1">
        <property type="nucleotide sequence ID" value="XM_016906144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CEJ4"/>
    <dbReference type="STRING" id="692275.M3CEJ4"/>
    <dbReference type="GeneID" id="27903281"/>
    <dbReference type="eggNOG" id="ENOG502RA09">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_816762_0_0_1"/>
    <dbReference type="OrthoDB" id="3800738at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF11466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="38535" checksum="348C185FCBB5C7AB" modified="2013-05-01" version="1">MAAATATLDTGELLELILLNLDTRTLLLSQRVDRRWHYIIRHSKMLQKKLFLLPTNTFDEILELGLLDAAKSERYNILDATSHRSKQFLEHIVILNDLLFDTTREWKLRNVAFADPAKRSGSNSNSNSNSNNNNNNNNHDHPHNTNNNTNNNYTNTNTMTFIPSWQRMLLTQPPPSTGKGDVMFWFEDAHDHDELCEGVNTLGDMMQKIYVKEASLTGFDVDWKSAAVRPVKHAVDGTYYMKLLAQRQRDCDVAAKQEEEEMLLLQKKKKRGRGRSRGGMGAVGQSSERFEEFFEEEIPRGGFYGGGNGDGNEVMTTTTITVATHDDATWPCEGAEFAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M3CF22</accession>
    <name>M3CF22_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">DNA mismatch repair protein MSH2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_149084</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the post-replicative DNA mismatch repair system (MMR).</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer of msh2 and msh6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760514.1">
        <property type="nucleotide sequence ID" value="XM_016905329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CF22"/>
    <dbReference type="STRING" id="692275.M3CF22"/>
    <dbReference type="GeneID" id="27902466"/>
    <dbReference type="eggNOG" id="KOG0219">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002472_10_0_1"/>
    <dbReference type="OMA" id="LVRFPQK"/>
    <dbReference type="OrthoDB" id="295033at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032302">
        <property type="term" value="C:MutSbeta complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000406">
        <property type="term" value="F:double-strand/single-strand DNA junction binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032137">
        <property type="term" value="F:guanine/thymine mispair binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000404">
        <property type="term" value="F:heteroduplex DNA loop binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032138">
        <property type="term" value="F:single base insertion or deletion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000403">
        <property type="term" value="F:Y-form DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007534">
        <property type="term" value="P:gene conversion at mating-type locus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043570">
        <property type="term" value="P:maintenance of DNA repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006311">
        <property type="term" value="P:meiotic gene conversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000710">
        <property type="term" value="P:meiotic mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000735">
        <property type="term" value="P:removal of nonhomologous ends"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043111">
        <property type="term" value="P:replication fork arrest"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03285">
        <property type="entry name" value="ABC_MSH2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.110:FF:000002">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000523">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000015">
        <property type="entry name" value="DNA mismatch repair protein Msh2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000017">
        <property type="entry name" value="DNA mismatch repair protein Msh2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011184">
        <property type="entry name" value="DNA_mismatch_repair_Msh2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032642">
        <property type="entry name" value="Msh2_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003810">
        <property type="entry name" value="PRK05399.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF35">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005813">
        <property type="entry name" value="MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="12">
        <location>
            <begin position="729"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="857"/>
            <end position="903"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00064337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF12393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="956" mass="106656" checksum="AAC81E316D9FA023" modified="2013-05-01" version="1">MGSRPELKVDDEAGFVKNFHQLEINKPTDTVRIFDRGEYLSAHGDDAEFIARVQYKTSAVLKTLGRSPGLPSVTMTITVFRTFLREAIFRLGRRIEVLESSGRGQWAVTKQASPGNLQDIEDDLGGHVDSAPIILSVKVSAKANEARNVGVCFADASVRELGISEFVDNDIYSNFESLIIQLGVKECLIQVDTTKKDAELHKLKTIADNCNCAIAERPAGDFGKQDIEQDLTRILRDEKAGGTLPQTDLKLAMGSAAALIKYLGIMSDPSNFGQYQLYQHDLSQYMKLDSSALKALNLMPGPRDGSKTMSLYGLLNHCKTPVGSRLLAQWLKQPLMSLEEIEKRQQLVEAFVNDTELRQTLQEDHLRSIPDLYRLAKKFQRKKANLEDVVRAYQVAIRLPDFIGTFEGVMDETYKDALDAVYTNKLRDHSDSFVKLQEMVETTVDLEALDNHEFIIKPEFDDTLRVIRKKLDKLRYDIDKEHRRAGDDLGMDTEKKLLLENHRVHGWCFRLTRAEAAVIRGKKQYPEIATQKNGTYFTTPRLSEMRREFDQLSENYNRTQSGLVQEVVNVAASYSPVIEQLAGVLAHLDVIVSFAHVSVHAPTAYVRPKMHPRGTGSTILKEARHPCMEMQDDIQFITNDVSLTRESSEFLIITGPNMGGKSTYIRQIGVIALMAQIGCFVPCSEAELTLFDCILARVGASDSQLKGVSTFMAEMLETSNILKTATKESLVIIDELGRGTSTYDGFGLAWAISEHIITEIGAYTMFATHFHELTALVDTHPQVQNLHVVAHIENGNEEGGEDVHMTNSGNNNHRRREVTLLYKVVPGISDQSFGIHVAELVRFPQKVVNMAKRKAEELEDFSGSGSGSGGQSNKTDQDRETSGSNLSHAAATATASTKQEDVEEGSRLLKAMLHKWKEQVEAENLDSEAQVQRMKDLVRGDAKLLANPFFQGVKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M3CFP6</accession>
    <name>M3CFP6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_141547</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760764.1">
        <property type="nucleotide sequence ID" value="XM_016902968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CFP6"/>
    <dbReference type="GeneID" id="27900105"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_22_1_1"/>
    <dbReference type="OMA" id="GHEKWIG"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000012">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF199">
        <property type="entry name" value="MFS EFFLUX TRANSPORTER INPD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032700" evidence="6">
        <location>
            <begin position="22"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="362"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="468"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF12643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="500" mass="53906" checksum="02F844A6B9722772" modified="2013-05-01" version="1">MVALCLAVLCMCLDMTIISTAIPRITDDFHALDDVGWYASSYMLTLSAFQLFYGKLYTFFSVKWIFMMAIFWFEIGSAICGSAVNSTALIVGRAIAGFGSAGIFSGALLIIAASAPLSKRPTYIGILGAMYGIASVTGPLMGGAFTDKLSWRWCFYINLPLGAVTVIFILVFYRETEQSRAQMLNDGWKARLSQFDLEGLAIFLPMVICLLLALQWGGAKYPWSSGRIIALLVVFGLALIAFVAIQFWKQDKATVPVRVLRQRSIAASSWLAFTLGASFFVFTYYIPIWFQAIQSASPVQSGIRNIPMVLSVVVSSAPTGVAVTLIGYYTPFALLSSVLMPIGAGLTTTWTPDSSASKWIGYQVLLGLGVGFGFQQTMLAAQTCLPKKDVPIGTAIVVFFQTLGGAIIVSVANNIFSSRLLSGIVRVVPELDPSIVLKTGATSLRDVIPVEYLPAVISVYNEALVGTFYVGTAMAALTIIGSALLEWKSVKGQKVHMVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M3CG43</accession>
    <name>M3CG43_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">H+/nucleoside cotransporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_149330</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760894.1">
        <property type="nucleotide sequence ID" value="XM_016905493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CG43"/>
    <dbReference type="STRING" id="692275.M3CG43"/>
    <dbReference type="GeneID" id="27902630"/>
    <dbReference type="eggNOG" id="KOG3747">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016813_1_1_1"/>
    <dbReference type="OMA" id="IVWHTVI"/>
    <dbReference type="OrthoDB" id="6075923at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008276">
        <property type="entry name" value="C_nuclsd_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011657">
        <property type="entry name" value="CNT_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002668">
        <property type="entry name" value="CNT_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011642">
        <property type="entry name" value="Gate_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590">
        <property type="entry name" value="SODIUM/NUCLEOSIDE COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590:SF4">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 28 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07670">
        <property type="entry name" value="Gate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07662">
        <property type="entry name" value="Nucleos_tra2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01773">
        <property type="entry name" value="Nucleos_tra2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="461"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="498"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="596"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="Concentrative nucleoside transporter N-terminal" evidence="9">
        <location>
            <begin position="217"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoside transporter/FeoB GTPase Gate" evidence="11">
        <location>
            <begin position="299"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Concentrative nucleoside transporter C-terminal" evidence="10">
        <location>
            <begin position="403"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF12773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="624" mass="67760" checksum="A99A8526288B1864" modified="2013-05-01" version="1">MAHASQDPALDPAHQHTHGHLHHGHNAHQQGDDVPVYTTGTTNERSTIPDPSPQEHGISHGPAYGSEKKGDYSVDIEQGNVITPAKSMEASEESPSKKRSFYRRYRLFIHFAIWLLATGWWVASLVLHRNDKNWVVPFLLWLAVTIRIVTLHTGTSFVTVPMHWTWNQTGVRVNNMIPERFRLWAGAVVTAATILVGTFASAETPTNSHENRAISLFGMVVLIAGLYATSKNRSKINWHTVISGFLIQFIIALFVLRTGVGYDIFNFISGLARSLLGFAGDGLAFLTSADWVDATPWFLVTVLPAIIFFVSLVQLLYYVGLIQWFVGKFAVFFFWSMRISGAEAVVAAATPFIGQGESAMLIKPFVPHLTMCELHQVMCSGFATIAGSVLVAYIGMGLNPQALISSCVMSIPASLAASKMRYPEEEESLTSGKVVVPDDDTHKAANSLHAFANGAWLGLKIAAMILTTLLCIIAFVALINGLLTWFGRYLNLNGEYDLTIELILGYVMYPVAFLLGVPRGPDLVKVGRLIGIKVVTNEFVAFTALTSDAMYADLAPRSRLIATYALCGFGNIGSLGTQIGVLSQIAPGRSGDVSRLAISALITGVLATLSSASIAGLVIQHELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M3CG58</accession>
    <name>M3CG58_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_117344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760909.1">
        <property type="nucleotide sequence ID" value="XM_016901327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CG58"/>
    <dbReference type="GeneID" id="27898464"/>
    <dbReference type="eggNOG" id="ENOG502RDF2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2252185_0_0_1"/>
    <dbReference type="OMA" id="VAAREIN"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032464" evidence="1">
        <location>
            <begin position="20"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF12788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="104" mass="11233" checksum="BC34F9882DF42E69" modified="2013-05-01" version="1">MYTKFIAAALCFSAALVAAREINQDDVPDQCLTTPQCQSVVSTATNCGSAATADNGDVFSDKYYLQCACQVDHHDLNDCVSCIQYYKDGGDIAKLQDECGHSHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M3CHI6</accession>
    <name>M3CHI6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_148613</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761374.1">
        <property type="nucleotide sequence ID" value="XM_016905030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CHI6"/>
    <dbReference type="STRING" id="692275.M3CHI6"/>
    <dbReference type="GeneID" id="27902167"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017278_0_0_1"/>
    <dbReference type="OMA" id="MIFRQKP"/>
    <dbReference type="OrthoDB" id="431169at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12245">
        <property type="entry name" value="RRM_scw1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000089">
        <property type="entry name" value="RNA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10501">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A/U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="375"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="193"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="197"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="235"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF13253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="568" mass="60077" checksum="D521399684F15974" modified="2013-05-01" version="1">MAEPASRSSHAVPSLHGSSMFPRTPFASNSTSPPTPAFRTDVFGQTSGASSGQIYGTSPTSERHPSDRNGAMPALSATVSDASEFAWEGRPAPAVLIRRLPRNIGIEAVKSMLIFAGDLIDTELIRSPYPADDQGFATALARFQTAESAFEAQRKLHGRPNTTKEANMIVEAHSTGSISSAYERRHTIDDTAFRTQNSSASSGRSRFNSTFQTTERISPPLATPSSAANGEFPTPENSAHFQNLFSSQSFLGNGTDGNQRISGKSMINDDTADDETGELLKDPIAYAKSGQQMRRATNPALPVTRFGSLSLNSPNGNHMGMVSPSSNGVGSPRANGSISSASTPMGSNAESVFGQNYPRPQYPPVNPADQNPPCNTLYVGNLPVDTSEDELKALFSKVRGYKRLCFRTKHQGSMCFVEFEDVSFATKALNELYGIPLHNSTKGGIRLSFSKNPLGVRSAQSNGMGLHPVMSPQAMAPGFSGMANGGNFSAVSGPPPGLGSPPGLCAGNNYRAVPTGMGGMFSNPFGGTSDFGHQLGPRNYSGGVPYALGSGTFGREPRTGYNDFSLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M3CIN0</accession>
    <name>M3CIN0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_84733</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761789.1">
        <property type="nucleotide sequence ID" value="XM_016910364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CIN0"/>
    <dbReference type="STRING" id="692275.M3CIN0"/>
    <dbReference type="GeneID" id="27907501"/>
    <dbReference type="eggNOG" id="ENOG502RX9H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027816_3_1_1"/>
    <dbReference type="OMA" id="WIVWIAC"/>
    <dbReference type="OrthoDB" id="3162524at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF697">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="428"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="462"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="80"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF13668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="514" mass="54976" checksum="A8401E519C01CF24" modified="2013-05-01" version="1">MADEKHAIRTSSDKSPPDSTIAAVDFSAGTTESLKHPDKYTVTEKKEQDDRCSSHGKAGDDAEESEVFGATGEGKVNFRTVGWIRASMFLMKQTFATGVLSMPSAMYYLGGVMSPLFIVFWGLVNTYSAIIQGNFKLAHPKMHTIIDGAEIAVLDLSKSKFWSKFAKFIAEVLYLMSWLLCIGLAVLAIGTALNAVTKHGTCTVAFNVIAMLVSIATGSIRKIHGLGIILWIGFVSALVSVLMVVVAVAIRSRPAYAPQTGPFDLGFQPGPPPGTTFAQAWAGAIAIYASSSNTCGYIPVMSEMRRPQDFFRALYVSATFVNTAYLSLATVMYAYAGKYVTSPALGSAGPTIKIAAYAVALPGLCAVGMICVHVPAKTVFVRILRGTRHLTENTATHWIVWIACTVSCGFVGWLLAVAIPFYTSLVSLIGSMGFGPLGVVLPPLLWFSIHPGYRTGTWKEQGLWWAHVAMLLLGLLLSIGGTYANISNIADQFRAGKVGTAFSCADNSATVVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M3CJP2</accession>
    <name>M3CJP2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Actin-crosslinking protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_147886</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FRG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762159.1">
        <property type="nucleotide sequence ID" value="XM_016904576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CJP2"/>
    <dbReference type="STRING" id="692275.M3CJP2"/>
    <dbReference type="GeneID" id="27901713"/>
    <dbReference type="eggNOG" id="KOG3962">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062276_2_0_1"/>
    <dbReference type="OMA" id="ACDVNGK"/>
    <dbReference type="OrthoDB" id="5539371at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23339">
        <property type="entry name" value="beta-trefoil_FSCN_fungal_FRG1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008999">
        <property type="entry name" value="Actin-crosslinking"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010414">
        <property type="entry name" value="FRG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12928">
        <property type="entry name" value="FRG1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12928:SF0">
        <property type="entry name" value="FSHD REGION GENE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06229">
        <property type="entry name" value="FRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50405">
        <property type="entry name" value="Actin-crosslinking proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF14038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="275" mass="30901" checksum="12016F5C84EEFFCE" modified="2013-05-01" version="1">MVKALSFKGDKKPTKKRKRAEKEADDAHDENEHAPPASKQLVSAHQQPEAEDDENWVSADAIDDIAGPVILVLPSEPVACVAVDQLGRVFTSKIENMVENEPHSAEPHDVRQVWVAQKIVGNENTFTFKGHHGKYLGCDQYGILSSTREAVSPEETFKVVPAEGKSSQFEIQTMMRKTYLSVDGDKDPAEVRGDAEAADETTCIRIRMQARFKPKLKTEKAEKVRAKISRKELEAEVGRRLDDDEVKKLKKARREGNYHEVMLDVKVKGKHDKFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M3CMU1</accession>
    <name>M3CMU1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_147094</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763249.1">
        <property type="nucleotide sequence ID" value="XM_016904076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CMU1"/>
    <dbReference type="STRING" id="692275.M3CMU1"/>
    <dbReference type="GeneID" id="27901213"/>
    <dbReference type="eggNOG" id="KOG1729">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082207_0_0_1"/>
    <dbReference type="OMA" id="LDQDANY"/>
    <dbReference type="OrthoDB" id="10018316at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15760">
        <property type="entry name" value="FYVE_scVPS27p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052113">
        <property type="entry name" value="FYVE-type_Zinc_Finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39490">
        <property type="entry name" value="ARRESTIN DOMAIN-CONTAINING PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39490:SF8">
        <property type="entry name" value="ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="160"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="61"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="235"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="94"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF15128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="278" mass="30601" checksum="07D43FE3958A9B53" modified="2013-05-01" version="1">MMATTSFSTQQPNHSKYYMNPSAGPSPPEATYNYPPPSNNISPTNCHANVRQLRQPRQPLYVPAALRPNEKITRPTDIPGRPRAIDTPPTSTESSFDSGRAASPSSSSKNDFLAFQFGQVDGGDHASLPHGLSRAASETLSLEEMGPVTGAPTTAHWKPDESAKGCYVCKVTFGWLLRRHHCRRCGNVVCYAHVRNVIPLDQNARIHPEGHRSKSCDPCHEEYKTFKKLWHSRANSVTDSTHSSQGTAMPIPNQSRQTEDARVGSMARSEGGMVWSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M3CXG2</accession>
    <name>M3CXG2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetolactate synthase small-subunit-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_152041</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetolactate synthase small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756472.1">
        <property type="nucleotide sequence ID" value="XM_016907207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CXG2"/>
    <dbReference type="STRING" id="692275.M3CXG2"/>
    <dbReference type="GeneID" id="27904344"/>
    <dbReference type="eggNOG" id="KOG2663">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055003_0_0_1"/>
    <dbReference type="OMA" id="CARSGMM"/>
    <dbReference type="OrthoDB" id="2013116at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990610">
        <property type="term" value="F:acetolactate synthase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04878">
        <property type="entry name" value="ACT_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.260:FF:000001">
        <property type="entry name" value="Acetolactate synthase, small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1150">
        <property type="entry name" value="ACT-like. Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004789">
        <property type="entry name" value="Acetalactate_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019455">
        <property type="entry name" value="Acetolactate_synth_ssu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039557">
        <property type="entry name" value="AHAS_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054480">
        <property type="entry name" value="AHAS_small-like_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053050">
        <property type="entry name" value="ALS_regulatory_subunit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00119">
        <property type="entry name" value="acolac_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31242">
        <property type="entry name" value="ACETOLACTATE SYNTHASE SMALL SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31242:SF2">
        <property type="entry name" value="ACETOLACTATE SYNTHASE SMALL SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22629">
        <property type="entry name" value="ACT_AHAS_ss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10369">
        <property type="entry name" value="ALS_ss_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="6">
        <location>
            <begin position="84"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF08351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="342" mass="36907" checksum="A42DACE52A2823FA" modified="2013-05-01" version="1">MASKRAVQLLSKQFQSSTILKTTTATQIRQQSSTSAIAWKALNRRIAPLPTVTGQSSAITPAAAVSSILYETPVPDKAPPKRHILNCLVQNEPGVLSRVSGILAARGFNIDSLVVCSTEVADLSRMTIVLQGQDGVVEQARRQLEDLVPVWAVLDYTQAPLVQRELLLAKISILGPEYFEELLAHHREMTGSTSQYGDAARGAIASGELGNIDGQADTTSATSASFEEDMDAGGVSHVDFHPRNLAPSEALRMKHQHLETITYLVHQFGGKILDISTNNCIVELSAKPTRIDSFMKLITPFGILESARTGLMALPRTPLDGAENEQTVEVEEVMDAASLPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M3CXL6</accession>
    <name>M3CXL6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_121185</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756522.1">
        <property type="nucleotide sequence ID" value="XM_016901664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CXL6"/>
    <dbReference type="STRING" id="692275.M3CXL6"/>
    <dbReference type="GeneID" id="27898801"/>
    <dbReference type="eggNOG" id="KOG1014">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_781122_0_0_1"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43431">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G14000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43431:SF7">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G14000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO-type" evidence="9">
        <location>
            <begin position="219"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF08401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="355" mass="39758" checksum="EDDB7B02C089C12E" modified="2013-05-01" version="1">MRALSMSIAREYGPKGVHTAHVIVDGVIDTDFTKKWTKDMSTEATIAPGDIAESYWSLHTQSKRCFTNEIDIRPMLEKCISDTLKVSSSQVNNTSSFIYPLKMNPKPCTICSLAPPNPPQALPISAPFTPDNNKDLSTCFIEFANKIYQIYWKEPSTQYPDLTNFPSLQEGTTYEPVPLSPPIAELFATSTLINYGVDGCIRCTHSDTELLPIVKIALPRQISRARVQYEIAMLKEMKRCEIPVPEFDPVPLVDLEGGIFGYRMEKLFSLDFKALGAVKEELREIVDRLHECGFSHGDLNPSNVMRDGRGRLVLIDPSFSGKIGEVVPSHVPSWQYEGSVFSTATDETYLKQFFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M3CXW5</accession>
    <name>M3CXW5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">UDP-N-acetylglucosamine transferase subunit ALG14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Asparagine-linked glycosylation protein 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ALG14</name>
        <name evidence="12" type="ORF">SEPMUDRAFT_136659</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway. Anchors the catalytic subunit ALG13 to the ER.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 11">Heterodimer with ALG13 to form a functional enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ALG14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756637.1">
        <property type="nucleotide sequence ID" value="XM_016902788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CXW5"/>
    <dbReference type="STRING" id="692275.M3CXW5"/>
    <dbReference type="GeneID" id="27899925"/>
    <dbReference type="eggNOG" id="KOG3339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064541_0_0_1"/>
    <dbReference type="OMA" id="FSMLRRM"/>
    <dbReference type="OrthoDB" id="17098at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043541">
        <property type="term" value="C:UDP-N-acetylglucosamine transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004577">
        <property type="term" value="F:N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013969">
        <property type="entry name" value="Oligosacch_biosynth_Alg14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12154">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12154:SF4">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE TRANSFERASE SUBUNIT ALG14 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08660">
        <property type="entry name" value="Alg14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF08516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="269" mass="30181" checksum="0A8F2D08D53F4BEA" modified="2013-05-01" version="1">MDRPLLIYILLLVSSAFFLLSRLLTILNPARPKPFRPSRRHAQEPTHLLIVLGSGGHTAEMLAMLERSMTEPDHSLRLDLNDFRHRTWIVSSGDALSAERARDFERRVDELYEQRVSSNSVSESSASSTSWSEGGRGTFDIQTVPRAREIHQSLLTAPASCLRCFVACVMVLSQYTGGPGELDFPDLILVNGPATGTIVVLASLVLRFFEVWGCNWKGKMRTIYVESWARVKRLSLSGRLLESVVDRFLVQWPQLERPGGRAEFVGVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M3CYN1</accession>
    <name>M3CYN1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_135212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF09764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757885.1">
        <property type="nucleotide sequence ID" value="XM_016902690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CYN1"/>
    <dbReference type="GeneID" id="27899827"/>
    <dbReference type="eggNOG" id="ENOG502RXAR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034763_2_0_1"/>
    <dbReference type="OMA" id="GGNCLYP"/>
    <dbReference type="OrthoDB" id="190201at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="136"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="405" mass="42564" checksum="249E3F44ABD35FC4" modified="2013-05-01" version="1">MRYSTSALALAASASAQYSSDFLPSNPGGAIPAGIEAPTTAGFQNATIQPARGGLAVCSTGVVEVTAGTTMNLKFKNFNLPTNQSSVTGTFVDMGTSGSPFMQDIMGGMQSVNGTYKIGATLCTPANNTQPDQVQILTHGIGFDRYYWDFAPGYSWVDVAAQYNHATFFYDRLGVGKSDTPDGLNVVQAPLEVEIAHQLIQMLRAGKFGHFSKVVGVGHSFGSIITQAITSQYPADLDAAVLTGFTGNSSAVAPFLLSLNLALASNNAPYRFASVPADYLVSSSAISAQIGFLRTPGFDPSILNLAEATKGTTTFGELFSLTASTRPAMNYTKPVAVVNGANDFPFCYGNCTFPMNLAEAVFPALYPAASRTGAYLAEVAGHGLNLHYSAVEAYRFAQDFLGVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>M3CZC7</accession>
    <name>M3CZC7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_111496</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF09021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757142.1">
        <property type="nucleotide sequence ID" value="XM_016900918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CZC7"/>
    <dbReference type="GeneID" id="27898055"/>
    <dbReference type="HOGENOM" id="CLU_963676_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032157" evidence="2">
        <location>
            <begin position="28"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF09021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="289" mass="31789" checksum="4F49C1A5F4E01BBC" modified="2013-05-01" version="1">MSNAILQTRTLTVWRLRWLAFAPVSCASPVGHRKPPADRTLRLVYAQDTAGLPTSEEESDLIMNMQADVEVDVAAGDTYRSIRYWGTTFTQRLCAMRNRTSAILSILSMLSILPEVCIEPFPRDGAVHAVSRTRDERVASSGCYVPRLSSHVQASHNPNDLVQSAVRVRRVQRRKCAGASKSRGSDVLTPRRREHRDNAFTHLGQGHRLYASLGVQCSPAMSMLQPSITPMSEVHAENAENAGNAGNARPLEPTASPGRYWTGSGLLVVVVVLLLLLLLVLRRASHTSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M3CZW1</accession>
    <name>M3CZW1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_150927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF09783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757904.1">
        <property type="nucleotide sequence ID" value="XM_016906480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CZW1"/>
    <dbReference type="STRING" id="692275.M3CZW1"/>
    <dbReference type="GeneID" id="27903617"/>
    <dbReference type="eggNOG" id="ENOG502SJ1Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024207_0_0_1"/>
    <dbReference type="OMA" id="YKFIPEW"/>
    <dbReference type="OrthoDB" id="2922289at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40788">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40788:SF1">
        <property type="entry name" value="IPA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="726" mass="81457" checksum="A4C062E946A0CF9F" modified="2013-05-01" version="1">MATRKSDMLKPEGNINIPELQSDLRRKYRNVGAKVEEIWRNFTPKQREKAMREAVGDGKVLKHSRDPGLAGLRRVLPDWNLQDITSTPDFFLDRLKHRVKTSLQTQHFEGANGGPGDQEIIRPGAQTININENKFGLFISDDEQYGQYVETTGAEARRAFIENMPVKVRLVIPGNEAYLVISRQTSTFIFYNSLIEEILDLGSDSRATKTASSARKATKEPANAMAKLALEPKPLKSSIAEVIAQAVEQKVALEDYLALLRSEPVVLNQSVNMTNSSRPELVPDDRGRILPMFTDKYITTAFFEVMCNAVKTIVTWEYIVRLVRMLEGDGMNDKLKRPVVVQELSNTCHLEYRRAQSELRRQMSQPAGMASKCFRRITTGGTSRVVIKGQPADYTVSDPQLHYILRICHPDAKHTEAAQWMQRLDDHNTRHPDDFQRLTEFQVLALGDVAIIVSFMHTLSTSLAMVAGSKKLGVLFTTRMGELDAELAQYKGEADFSDHVVPMGNLLEPGVASKALESLENFVIERAGTSLGGLYEEILHDCVTDVEKKCSDAKLNFDKAQSQQQQQQQPLAPPIVEEPKPASFRAEQRREKAKTRPAEEVSAYNITALTPAQLEVAEEPTPQRLKVKPSTASVFFTIFAKSQARGSVSWANFTSAMADLNFSVTPKYGSVFTFHPPQSMGATRSVTLHRPHASDIEGYKLLIVSRRLYRTYGWTQETFEVEESVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M3D0J9</accession>
    <name>M3D0J9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_90957</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IUNH family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF09988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758109.1">
        <property type="nucleotide sequence ID" value="XM_016910543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D0J9"/>
    <dbReference type="STRING" id="692275.M3D0J9"/>
    <dbReference type="GeneID" id="27907680"/>
    <dbReference type="eggNOG" id="ENOG502S3M0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055874_0_0_1"/>
    <dbReference type="OMA" id="AHVVNNW"/>
    <dbReference type="OrthoDB" id="187522at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43264">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43264:SF1">
        <property type="entry name" value="INOSINE_URIDINE-PREFERRING NUCLEOSIDE HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="Nucleoside hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032743" evidence="2">
        <location>
            <begin position="21"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Inosine/uridine-preferring nucleoside hydrolase" evidence="3">
        <location>
            <begin position="31"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF09988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="388" mass="42575" checksum="B65FDEC8D4A3703E" modified="2013-05-01" version="1">MLLASVLFHFLATTPLFSRATGTSRSAPRPVIIDTDLYSDVDDVGALAIANVLHNCGLCDLRGIAINTPSKYGALAASAINTYYNNPHIPISALQPFTDEIYVDDFFFLRSDYASKLAIHFPNFNNTLQTEEDDITIPSSTSNTNETKTNTLETPLEMYTRLLESTPEPNSITIISLGFLTNLATLLTSNTSSSGYELVQQKVQEIIIMGGTYPGPGWEFNFGEFPLETKTVLENFPSNVRVTFSGFELGGVVFSGKGLKQKKCDEEEEDKGGKESPIRAAYEWYVGRCSTLRESWDPITTLYGILGLKGLFLNSPLNGGDELFEFGNVGGGGYNKIVESNGTNLWMDDDGQQHNQRWLKLAEGVSNVTLAEILDGFYTHGPGGCELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M3D2J6</accession>
    <name>M3D2J6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transp_cyt_pur-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_65503</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760556.1">
        <property type="nucleotide sequence ID" value="XM_016909722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D2J6"/>
    <dbReference type="GeneID" id="27906859"/>
    <dbReference type="eggNOG" id="KOG2466">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021555_4_1_1"/>
    <dbReference type="OMA" id="WRTGGMI"/>
    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11482">
        <property type="entry name" value="SLC-NCS1sbd_NRT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000001">
        <property type="entry name" value="Uracil permease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF0">
        <property type="entry name" value="PURINE-URACIL PERMEASE NCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032775" evidence="8">
        <location>
            <begin position="27"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="377"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="443"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="487"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="527"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="569"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="569"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="586"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF12435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="614" mass="67821" checksum="C16814645AB9E135" modified="2013-05-01" version="1">MSTGGRSFLYPSSLSILSFTTPLCCAHQPATTMERTTNFIKSQIPSKATLKQRCTSLQSWQLPKQSSALAPDNVWTNKDMDPSPPQDQTWTIWTWIAYWATDCINLGTWETGSSIIAVGLTWREAIPIIFVGNLCVAIPMVLNGAIGAFLHIPFAVIVRSGFGYYFAYFAIVSRSILAMFWLGIQGANGAKCLTVMLSSIWPSYNEIPDRIGYERQGISSQGMISYFLFWIIQLPLLLIPPTRLRWLFVVKLIAAPVTAIATMAWCIHKAGGGGPLFEQKPTVSGSTYAYLWLSCMSSVTGSWSTLACNIPDFSRYAKSTKGQYVQLPALPIIFTLCGVIGVVTTSATNVIWPEDGYLWNPLDIMTHWQENGHGGRAAAFFAATSWYIATVGTNITANSISAANDLTVLFPKWINIYRGCILAAIIGGWVIVPWKILSSATTFLAFMGGYSVFLAPIAGIICSDFWLVKNQHLDVPALYNPRGRYRYWHGINWQGFLAFLVAVLPNLPGLAESISANLKISEGARNLYTICWLYGFVSSIVVYVGLHAVFPAKASLVERTIDGVEVVSERKEYSTSREGSEDDEEKSQGGEKHVEKVRVRVEQEEDDIKPVGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M3D3X5</accession>
    <name>M3D3X5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein L10e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_149227</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760725.1">
        <property type="nucleotide sequence ID" value="XM_016905428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D3X5"/>
    <dbReference type="STRING" id="692275.M3D3X5"/>
    <dbReference type="GeneID" id="27902565"/>
    <dbReference type="eggNOG" id="KOG0857">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084051_0_0_1"/>
    <dbReference type="OMA" id="HHVIREN"/>
    <dbReference type="OrthoDB" id="10258869at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="entry name" value="Ribosomal protein L10e/L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047873">
        <property type="entry name" value="Ribosomal_uL16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018255">
        <property type="entry name" value="Ribosomal_uL16_CS_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_uL16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001197">
        <property type="entry name" value="Ribosomal_uL16_euk_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_uL16_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003239">
        <property type="entry name" value="PRK04199.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00279">
        <property type="entry name" value="uL16_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11726">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005590">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="Ribosomal protein L16p/L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01257">
        <property type="entry name" value="RIBOSOMAL_L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF12604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="221" mass="25323" checksum="13FB65749EC25B93" modified="2013-05-01" version="1">MARRPARCYRYCKNKPYPKSRFNRGVPDPKIRIFDLGRKRANVDDFPMCVHLVSNEYEQLSSEALEAARICANKYMVKTAGKEGFHLRVRAHPYHVVRINKMLSCAGADRLQTGMRGAFGKPNGTVARVNIGQILLSIRTRDSHRPTAIEALRRSQYKFPGRQKIIVSKKWGFTPLDRAEYVEKRKAGEIRVDGAYVQFLSTNGPLAYNMRRFPEAFSQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M3D461</accession>
    <name>M3D461_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450 52A11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_149283</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760805.1">
        <property type="nucleotide sequence ID" value="XM_016905461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D461"/>
    <dbReference type="STRING" id="692275.M3D461"/>
    <dbReference type="GeneID" id="27902598"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_27_0_1"/>
    <dbReference type="OMA" id="EMIPGPT"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF5">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="499"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF12684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="552" mass="62187" checksum="5CA83E54A38B0C45" modified="2013-05-01" version="1">MLLLYLYDRLFWLTIAHALLAHLTYNLLPLAGASPLLSHILTFAVLGTYLVKTLDHLDRERRIRQLGKRATSLRTHTPFNIGVLLQVLWYLSKHRTHEYWWKMFGQRPGGGGAGNIGGENGRKFPYTVETITIGGRLVLTADEENVKAILATQFADYGKGPQFRKEWKDFLGLSIFTTDGDAWHTSRQLLRPQFIKDRVSDLQKFEHHVQKLLPMLAGVSNGETVRLDDLVYRYTLDAATDFLFGTGVGSLENGETGFAKAFADVQNVQGLIARAGPIRALIPKKKFYQGLEVLNKFTDRYIDQALALGPDELEKKSKSDEGYTFLHAIAAYTRDRQVLRDQLVAVLLAGRDTTAVTLSWLFYELSQHPEIVAKLRKEIIGLVGRTREPTYDDLKSMRYLNHVVNETLRLYPVVPYNVRVALQDCTLPHGGGPDGSEPIGITKDTPVGYSTFVMQRRADIYPPASSGFPDHLAFVPERWDNWTPKSWTYIPFNGGPRICIGQQFALTEIAYTVVRILQTFAKVESRMSGHPGFKSDIVLQPAAGVYVAFLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>M3D4B4</accession>
    <name>M3D4B4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_133392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760850.1">
        <property type="nucleotide sequence ID" value="XM_016902563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D4B4"/>
    <dbReference type="GeneID" id="27899700"/>
    <dbReference type="HOGENOM" id="CLU_2147447_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF12729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="112" mass="12458" checksum="93C116ADAC42BD37" modified="2013-05-01" version="1">MTQVYDKSCTTSFFWPPSRYDRAPASSTTSGDSPVDSQLRRPKPALRHTEFRTKPSLSAYARAGPRNTIDEQNWPAVLSQVSVYCTTVYCTKTLTNAAMETLMNVGATKKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M3D648</accession>
    <name>M3D648_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_132905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761771.1">
        <property type="nucleotide sequence ID" value="XM_016902525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D648"/>
    <dbReference type="GeneID" id="27899662"/>
    <dbReference type="HOGENOM" id="CLU_1062328_0_0_1"/>
    <dbReference type="OrthoDB" id="3650373at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF13650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="262" mass="27321" checksum="A73DD221E35050D8" modified="2013-05-01" version="1">MADNPFGQVGGFLSGLLNPVSEETKTQNVINTPIATSTGARETSTYSSLSATARTASAIDSTPSTSVLTSSTTAISSTPSTTSIPSTITEQHTTFDPAATSIAISTSSTLPSSTAATTAGPAQTSPVNAGAVAGGVVGGLAVLALLVFGILWLMRRPRKTPDEKKDHSSKPYENSVISLVAFGKDTNDSRPVTSSRPWNTSSSSSNKTFSSSAHLVGPSIYVTDEYDQRRKICELPGSAPVQPSSELESGQKYHAYRPRGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M3D695</accession>
    <name>M3D695_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Extracellular mutant protein 11 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_125416</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761821.1">
        <property type="nucleotide sequence ID" value="XM_016901983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D695"/>
    <dbReference type="STRING" id="692275.M3D695"/>
    <dbReference type="GeneID" id="27899120"/>
    <dbReference type="eggNOG" id="ENOG502STPQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_466272_0_0_1"/>
    <dbReference type="OMA" id="FECEIEQ"/>
    <dbReference type="OrthoDB" id="5346740at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070860">
        <property type="term" value="C:RNA polymerase I core factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001164">
        <property type="term" value="F:RNA polymerase I core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029178">
        <property type="entry name" value="Ecm11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053029">
        <property type="entry name" value="RNA_pol_I-specific_init_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28244">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28244:SF1">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15463">
        <property type="entry name" value="ECM11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Extracellular mutant protein 11 C-terminal" evidence="2">
        <location>
            <begin position="433"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="563"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="575"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF13700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="585" mass="64564" checksum="D6428310A6E085BD" modified="2013-05-01" version="1">MAQDGGADDTKALERKSSKLSDQEIQSMKVQPQATSTQGKSQANTRTARDIDGPGQMKRSQSGMRSAPKGMLSTDASNAVRTSASGSTQNAKQGKEKKPPVQVEPHADEVASDGSSVYETDEDEDDDGLQQPSVNQADIQTRNAHVPNVLTERRMTGDSYPATTSGVPSEVDVHDAQQQSQNHARGMQVPTGIMPVRGSGPRGGMTVPNVAVPRLDTLGQASRPAHVNITSEIGAGFQFGVAPAIQPKVNRSVHHGPQPMPHPQRNPPAQNHPPQGPGQQHRIVNQHLPQAPANAQRAPANTQAVSKLPASEKQVLVLPSNKPVIHQESHRQLGDVNHQDALPHPLHFTQMPAHERNVHKSHTSTVNPQPPSSDVQQPSDHQYSEFEYLNVGDGKDYGHMDEQYPEEQHAEDQPPEEQYSEEQHHPEERQDIDYAESELFSKSYADIKAQSFDLDPCAVPLNLPQELPTDNLHQKLVSVMKLKTQPQQPNPQFELFKSMTLTEWEEAGDWFLDRFSDLMAKLKAARKQKRKIAHDFECEIEQRHEAVAKKQKLTQAALDEMKMTGGKVLEGTPKKSPRKPTKAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M3D719</accession>
    <name>M3D719_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NAD_binding_2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_148895</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HIBADH-related family. NP60 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761795.1">
        <property type="nucleotide sequence ID" value="XM_016905211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D719"/>
    <dbReference type="STRING" id="692275.M3D719"/>
    <dbReference type="GeneID" id="27902348"/>
    <dbReference type="eggNOG" id="KOG0409">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035117_5_1_1"/>
    <dbReference type="OMA" id="IFSCIAN"/>
    <dbReference type="OrthoDB" id="435038at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051265">
        <property type="entry name" value="HIBADH-related_NP60_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580:SF3">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G11600)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580">
        <property type="entry name" value="OXIDOREDUCTASE GLYR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="5">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="6">
        <location>
            <begin position="164"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF13674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="297" mass="31579" checksum="1439F7BD0689C9C4" modified="2013-05-01" version="1">MGRGMVKNIVEKGEHSGPVLVYNRTTSRTEKLVSSLPEGKAKAITSISEAVQSSDIIFTCLSNDAAIEETINTALSSSPEAAKGKLFVDCSTVHPDTTNKLAQTINSAGADFVACPVFGAPAMADNGQLVCVLAGPKPQVNRVLPFCKGVMGRAEINYSDQPQGAATHLKIIGNTFILAMVEALSEGHVLAEKSGLGTENLHAFIEVMFPGPYTAYSQRLKSGDYFEREEPLFQAKLARKDAGHAKSLADKCGAKMNGLEVADAHLKQVVDHAGDRGDIAGIYGAVRKESGLKFENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M3D8A7</accession>
    <name>M3D8A7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_162317</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762230.1">
        <property type="nucleotide sequence ID" value="XM_016907995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D8A7"/>
    <dbReference type="STRING" id="692275.M3D8A7"/>
    <dbReference type="GeneID" id="27905132"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_27_0_1"/>
    <dbReference type="OMA" id="AKNPRIW"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="320"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="329"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF14109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="500" mass="57164" checksum="D1CFE5EEEEEE86BD" modified="2013-05-01" version="1">MSFISLPTPTQTLISLALLYTIYHIISAVDLWNRRRAFKRDRGVRDAPRLPQKDPILGLDLFLENIASLKNHTLLETTASRFRDTGLNTFRLVALGRHMHATLEPENLKTCHHAHSREMLRPNFVRSQVGDVQTFEKHVSRLIATIVPGQEVDLSERFFRLTIDSATEFLFGESTDSLIKDGNDGFSEAFTQSQDFIGNLARWGNWAKLFPANKRFQKDRDFVHNFVNSYVQKGLARRDQLLAAEKNSSPDHQQQQPPERYLFIDALVRQTTDPIRIRSELLNILLAGRDTTASLLSNLWFTLARRPDIWRKLQSEITTATILPPPPHQKSSSSPSSNSSSQPPTFDQLKSMKYLRACLNESLRLYPVVPLNSREALEDTILPRGGGEDGMAPIFIPKGGLVSWNLWALHRRKDYFGEDAEKKGLRPGWEYLPFNGGARICLGQQFALTEASYVTVRICQEFPEEEKEEKQEEEPWREFLTLTCTSLNGAKVVLNRYRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2024-01-24" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M3D956</accession>
    <name>M3D956_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-aminoacid aminotransferase-like PLP-dependent enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_148134</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762540.1">
        <property type="nucleotide sequence ID" value="XM_016904727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D956"/>
    <dbReference type="STRING" id="692275.M3D956"/>
    <dbReference type="GeneID" id="27901864"/>
    <dbReference type="eggNOG" id="ENOG502QQMK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020844_6_0_1"/>
    <dbReference type="OMA" id="VWLSNGV"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF14419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="30797" checksum="E5B094CBB9CC0655" modified="2013-05-01" version="1">MDGHFGSGIEEDGEPYVYTSVRYDKRLVHSPTNTAASCGTPCPFYMLEHHWTRLQIAKWSTFFFADDRPRPNSGGPAVLLNTLTRAIKQWHEKHPDENPEALRIKLRIYVGGRMRTEIYHPLKSIPLTALFPTSFEVSLKSSTDWTIVLDSQATEPSEGTMYKTHDRSLYGRARTSAQIMTYQEPKEVLLWTRENTVLDGSFCTPYFFRGGQWVTPESAVGGLQGTTRRWALEQKLCVEGSIPIDSFQDGETVWLSNAVRGYFWAVFKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M3D9V2</accession>
    <name>M3D9V2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_155326</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762780.1">
        <property type="nucleotide sequence ID" value="XM_016907613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D9V2"/>
    <dbReference type="STRING" id="692275.M3D9V2"/>
    <dbReference type="GeneID" id="27904750"/>
    <dbReference type="eggNOG" id="KOG4400">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_947209_0_0_1"/>
    <dbReference type="OrthoDB" id="7608935at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="130"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="77"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF14659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="294" mass="33288" checksum="B0B1E0522A825BC8" modified="2013-05-01" version="1">MSDLENDSRATAVGRKRKYGHTFTNTTTTASRRSSDTSKESGEISSSEEEDSDSDIEEISAAQWKQRPSKKKKKKTTSSSSSSFSANYTSSDEGDDGYDDGMIRLCNIPPNDQIEQCRYFNITDMSEVVRCLCCGEKGHMAKDCETRTCRHCQKRDLHPSNACPIIRKCGLCRKRGHDAATCRNRSFRGADPCDVCRKIGHVEFLRLPFQVGVEPLSMGTACEDANQVQEECPRLWCIYETPCQPKKSEVIEIEDDEVKRPEVIVIEDDEENKAPTREQRLPWQLMGAFDDTRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M3DA13</accession>
    <name>M3DA13_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_28030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF14905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763026.1">
        <property type="nucleotide sequence ID" value="XM_016908438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DA13"/>
    <dbReference type="STRING" id="692275.M3DA13"/>
    <dbReference type="GeneID" id="27905575"/>
    <dbReference type="eggNOG" id="KOG3216">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_41_2_1"/>
    <dbReference type="OMA" id="QSEWVRY"/>
    <dbReference type="OrthoDB" id="7305308at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051016">
        <property type="entry name" value="Diverse_Substrate_AcTransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545">
        <property type="entry name" value="DIAMINE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545:SF29">
        <property type="entry name" value="GH14572P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="43"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF14905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="187" mass="20410" checksum="C27052C98DF622B6" modified="2013-05-01" version="1" fragment="single">DVPEILAMIQGLADYESASSKVEATEESLLQTLIFATPATDISSTSTASPTTTTTTTTIEHASPGYAKTLLLRLPTSLSESDRAANFTPGAVAGMAMYFNNYSTWRSKPGVYLEDLFVKPQYRKRGYGKALIQALAQEVVRIGGGRLEWSCLKSNTASLAFYKSLGAEQMVDWVQLRVDGERLERLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M3DA25</accession>
    <name>M3DA25_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_146945</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF14920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763041.1">
        <property type="nucleotide sequence ID" value="XM_016903980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DA25"/>
    <dbReference type="STRING" id="692275.M3DA25"/>
    <dbReference type="GeneID" id="27901117"/>
    <dbReference type="eggNOG" id="KOG0463">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012821_0_0_1"/>
    <dbReference type="OMA" id="FRFIQRP"/>
    <dbReference type="OrthoDB" id="248233at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04165">
        <property type="entry name" value="GTPBP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03694">
        <property type="entry name" value="GTPBP_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03708">
        <property type="entry name" value="GTPBP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000014">
        <property type="entry name" value="Probable GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000091">
        <property type="entry name" value="Probable GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035531">
        <property type="entry name" value="GTPBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF9">
        <property type="entry name" value="GTP-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="5">
        <location>
            <begin position="187"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF14920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="651" mass="71010" checksum="0B47851B56C3F524" modified="2013-05-01" version="1">MATRAERYKEVPQTAQDRRAGENALSDFADYVNKQQALRRPPINGPDTTTGSNTEHAELDILDTLDLGDDKPKVRLKHLLLDDTEKEESITQLGAVISSRLDEGHNECLFDVGLEDNGDSQLLTEQEWDAAIARLQGIVEKLKADWKVLMTKNVPNSPVDVGNESNKARGCVGKLMIRRRPVDVDDQIETRIAVVGNVDAGKSTLLGVLVKGGLDDGRGKARVNLFRHKHEIESGRTSSVGMEIMGFDTKGEVVVSGVPGRKLSWEEIGKRSAKVISFTDLAGHERYLRTTVFGLLSSEPNYCLLMVAANNGLIGMSKEHLGIALALNVPVMVVITKIDICPPQILQQTITQLTKILKSPGARKIPIFIKTREECINTATQFVSQRICPIFQVSNVTGESLDLVREFMNILPHHGKYDIDAPFEFHVNDTFSVPFVGTVVSGVVKSGIVHAGDTVMVGPDGLGQFTTTTVRSIERKRISTPAATAGQSASFALRRVRRKDVRKGMVVLLAKSDANPHLEAPKPQVYREFVAEVLILSHATTIRTKYQAMLHVGPVSQTCAIIDIDRDYIRTGDRATVAFRFVQRPEFLAAGDRILFREGRTKGLGIVKAVGYDPNKPLNPEAAAKLQHQGDSGSGKGLVATAAAAAPTKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>M3DB91</accession>
    <name>M3DB91_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_154018</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763240.1">
        <property type="nucleotide sequence ID" value="XM_016907539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DB91"/>
    <dbReference type="GeneID" id="27904676"/>
    <dbReference type="HOGENOM" id="CLU_1272964_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF15119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="217" mass="23184" checksum="B369BEEF6332DEB6" modified="2013-05-01" version="1">MCPARSIIERVRHEEVAAAFRVAIPARDTAGRAEDRAADGETCKSCKAASDPVPHRSVILEDNTTPFSAGRPPNPKAPLYSATTKNKTSLAPACHSFEACGASDIFLPLTYRPQAITCKTFNLDIPINTDSGRDSKKPASKANPMPGVACSACAGPVRRMVQDCIALTLTPLQIRLIDARHSTDIPAHSIIVNPNVGFPVQIHLSYQAAKIADRSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M3DBC1</accession>
    <name>M3DBC1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_79520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016910222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DBC1"/>
    <dbReference type="STRING" id="692275.M3DBC1"/>
    <dbReference type="GeneID" id="27907359"/>
    <dbReference type="eggNOG" id="ENOG502SV8I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1042686_0_0_1"/>
    <dbReference type="OrthoDB" id="2129362at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF15149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="267" mass="30772" checksum="49F5753E6BC0ABB2" modified="2013-05-01" version="1">MRRAKACEKRQVAQYADCVWEPEFLKPIRDRKLAGIYLRHAVSDDMEAVCNILNYYVEHTTSVSETERPTVMELREQFKKITQQSKLPFLVACEKGALLRAKYSRNGDLLLDPRQLPDTIVGFGRAVDYGNGDEMYRSTAVLEIFIRQTHVLRRIGTCIMDKMLGLLDPDHIERGGYEVGDDNLEGARPVRNIKNIVVDYLYSTDRPERLESMRRRLVQGYQFEEVGKLRDIGRKLDRSVSKAVFMRTTGAVLDHTDPPEVIYSAWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M3DBN4</accession>
    <name>M3DBN4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calcium-dependent phosphotriesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_59902</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763390.1">
        <property type="nucleotide sequence ID" value="XM_016909509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DBN4"/>
    <dbReference type="GeneID" id="27906646"/>
    <dbReference type="eggNOG" id="ENOG502S58R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035172_0_0_1"/>
    <dbReference type="OMA" id="NDHYITK"/>
    <dbReference type="OrthoDB" id="5307922at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051288">
        <property type="entry name" value="Serum_paraoxonase/arylesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11799">
        <property type="entry name" value="PARAOXONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11799:SF30">
        <property type="entry name" value="SERUM PARAOXONASE_ARYLESTERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF15269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="411" mass="45415" checksum="A7F580DD01130A9A" modified="2013-05-01" version="1">MAAKSYAPLSLLVLLIAFIYARWSILPTFYLNAPGRLTPINAVNSEGSYEVRFKHFIRNCEDIHLNEEEGWVMLSCDPGRDKWNTVLGILEDSSTHPDAGIYMWTYREAPQSRPFKLQLDPVHEGADAFHPLGIEYHEESKRLFVINHNPSGTRLEWYKVDILSKTAKLEGTFRDAQNLPTPNALVAISENELLITNDHYMPIRDHRTLARLETYAGIAGGSIAHIHLSGSDNSPQITTLTRMPFANGIALLNKSTIAVASSSTASIRLFHVDWSQKTTGQAAAAAPPSLTPLSSIPLPFLPDNLSADSKGTLLIAGHPHTPSVERVGKENRYCQVEATSPTAEEDGKKCDPKLPKMSWVAEWSATKGLKNLYVGKEYGTASSVVKDWISGVGMVVGLYENGLMMWTLDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M3DBU5</accession>
    <name>M3DBU5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_161692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763651.1">
        <property type="nucleotide sequence ID" value="XM_016907953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DBU5"/>
    <dbReference type="STRING" id="692275.M3DBU5"/>
    <dbReference type="GeneID" id="27905090"/>
    <dbReference type="eggNOG" id="ENOG502RIUV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046102_0_0_1"/>
    <dbReference type="OMA" id="VDWARTC"/>
    <dbReference type="OrthoDB" id="3447202at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11616">
        <property type="entry name" value="SAF_DH_OX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048423">
        <property type="entry name" value="DRL_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013974">
        <property type="entry name" value="SAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37850:SF3">
        <property type="entry name" value="BLR7815 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37850">
        <property type="entry name" value="STRU PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21135">
        <property type="entry name" value="DRL_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08666">
        <property type="entry name" value="SAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00858">
        <property type="entry name" value="SAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAF" evidence="1">
        <location>
            <begin position="365"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF15530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="456" mass="48973" checksum="F72C60FAB3FBD299" modified="2013-05-01" version="1">MTSLSTKLAEREAAGKPIQIGLIGAGKFGSMFISQSHRTPGMRLAGIADLSADRAVAALRRTSYPPDRFDHTASLSVEEGLAAGKTAITQDSAALIATPGIDVILEATGSPAAGIRHALLCCEHQKHIVMINVEADVLAGPLLARKAREAGIIYSMAYGDQPALIAELVDWARTAGLDVICAGKGTKHLPQYHHSTPDTVWEHYGFTKEQLASGDFNPQMFNSFLDGTKSALEMAAVANGCDLVPPDNGLLFPPCGTHDLPHVLRPKADGGMLDKKGTVEVVSCLETDGRPVHNDLRWGVYVIVEAPGEYQRECFKQYGLQTDSTGKYAVQYKPYHLIGLELGISVATIMCRGEPTGQTRTWAGDVVATAKRDLRAGEKLDGEGGFMVYGILIPARASMEIEGLPIGLAHGLVLKNDVKQGQGLSWKDVEYSADTQAVAVRKAMEAMFKKQFEQCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M3DC85</accession>
    <name>M3DC85_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">STAG-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_123720</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763540.1">
        <property type="nucleotide sequence ID" value="XM_016901856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DC85"/>
    <dbReference type="STRING" id="692275.M3DC85"/>
    <dbReference type="GeneID" id="27898993"/>
    <dbReference type="eggNOG" id="KOG2011">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003254_0_0_1"/>
    <dbReference type="OMA" id="FVANVQD"/>
    <dbReference type="OrthoDB" id="498590at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039662">
        <property type="entry name" value="Cohesin_Scc3/SA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056396">
        <property type="entry name" value="HEAT_SCC3-SA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020839">
        <property type="entry name" value="SCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013721">
        <property type="entry name" value="STAG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11199:SF0">
        <property type="entry name" value="LD34181P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11199">
        <property type="entry name" value="STROMAL ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24571">
        <property type="entry name" value="HEAT_SCC3-SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21581">
        <property type="entry name" value="SCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08514">
        <property type="entry name" value="STAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51425">
        <property type="entry name" value="SCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCD" evidence="3">
        <location>
            <begin position="358"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1005"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1109"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="666"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1009"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1118"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1141"/>
            <end position="1173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF15419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1173" mass="130051" checksum="6599D5E7CD522FC9" modified="2013-05-01" version="1">MSASVSPAPTGGDGAIRRASGRVRKQPQHFTSSPYGGAKRKRDDATDANGDEDMVDDDDNDANDDDSDDEDDPEDEPDEEEMRERAKKSRQVKKAAAAKKPPQKKARTQTNGVTLPIRSTAKPSARKRPPKKPQGIDGADAEAAGGIYADLFARNKPADEVVAQWLASFKDDETVALTDVINFLIKSAGCSLKVTKHDIEDPDGVTEKLRDLQTEHQASQPTDYPLIAKGKSGTLFRQNITNFMKQLIKSISAAGLLIENPELLENISVWFSTMSSASDRSFRHTATVLSLSVVTALCEISTQLADQLPNFQRQVAAEQKKKRVNVQRVKDVEAKVKQANDDLEYMEALLKDWFDTIFIHRYRDVDPLIRRECSEAMGDWAMAKPEHFLNGNHLRYLGWVLSDTQALCRLEVIKQLRRMYHDTDNLGGLRTFTERFRLRLVEIGTSDADMSVRVAGIELLDMLRKSDLLEPDDIDAIGRLIFHDEIRVRKAVAGFFSENVKDLFSAKLDELGGIEKLEEELPEVGPGTFETPQLAWLQLKSLAEMLQSYDSEDPVSSQFERSGTDGSLIINVVGTESRFTLAISAIYDRLPELEEWRSLAGYLLFDHSVGRANGVGNDTLSRLKHECTLTEQEELILLEGLNATVRRKLSDLAEQHVHHAKGKLTKKQKEDLQEELEENVRHLTDSLPRLLKKFGDMPGTAAAVLRLEGVFTIPALRSLRQDPTVNGALLDDLHKQFMSHGTDEVLGPATNAILHAKAYGELDDTAMEKISSLWDDVVNNINELINVNTLTVRGALTEEELVALGNNLLRIVRLATISSPVAALEDESHVLSNPATDKNSSGTIDFIIGLLKRALHSSGPELEPEEAALEDIVVARAAEAALFYFRWKLSALAAAVRTGATSELDTDRVLEPLCERRDAYVENIRMVLDGRKPSESVRYSLTGSLLDLYTSGAVLRTVNAKAGVSEDYTVLIMELEPESEQAVLKTFAILEKAFARLSGKKLEEHVKDDEEMDVDADPIDADPLSESEDDEDEPETQMSQQARDAKLARPLIAEQKLCILTAKIIQADAAGVLVDKSIRRRIERNKSKLGPNFKEVVAYLDKFRIEKKSAAKSKAKTKPNTAANGAPKKGKANPKSNAIVAEDEVDDEIEDDEDSEAEPQDIDQGEDESVHDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M3DCT9</accession>
    <name>M3DCT9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_147613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763961.1">
        <property type="nucleotide sequence ID" value="XM_016904414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DCT9"/>
    <dbReference type="GeneID" id="27901551"/>
    <dbReference type="HOGENOM" id="CLU_1262214_0_0_1"/>
    <dbReference type="OrthoDB" id="1431934at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF15840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="219" mass="25193" checksum="249B1CE13FCA99AA" modified="2013-05-01" version="1">MASTSGEGANQTNEEEEEKNEKNEKKKFRLKDLVAYWPKLFPHRPRRECEICCERKLHKAFSHHKYIPYECRPHLQTFCLSCIRSSLSAQLDTKPVLAMGCPQCAVPWNWEYSILLLGYKDRKKYRRLNLLAQGRVFVPAPKDMPEAATLDFLLDTGVRLCPWCQFPFCKEGGCDHMSCSKCAQAFTLSYAPVLGDEHGRRARPPLCDVRVHVNGLEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDE2</accession>
    <name>N1QDE2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sexual development protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_91987</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757487.1">
        <property type="nucleotide sequence ID" value="XM_016910574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QDE2"/>
    <dbReference type="GeneID" id="27907711"/>
    <dbReference type="eggNOG" id="ENOG502SM3U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045147_0_0_1"/>
    <dbReference type="OMA" id="IKPCEYK"/>
    <dbReference type="OrthoDB" id="5293813at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13668">
        <property type="entry name" value="Ferritin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF09366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="36785" checksum="059C13C964EF484D" modified="2013-06-26" version="1">MECPVPTVPAKMGPGAKKPQVPFKFPLANGFPDLMVPSPELTAVEKLAQGTLPNGALPKNISDASATNLQLVAFNEIFEVAYFNSLLSNLTTGEYDLGAAKDFVVKAIDTVQAQEQLHALGANAILASAGRTTIKPCEYKFPAADFDTAISTATLFTEVVLGTLQAAQTTFATTGDSELVGLFGSVIGQEGEQVGYYRATGRKVPSSLPFLTGGAGAFAFSALNQLFVVPGSCGNLEEIKIPLLSPLTVVTPPPATGGDATITYSYPVLPSVTSPENLRLVLINQQNVPLVFPLGDLQRNGDTVTFTAPWPYTNATLNGLTIAAVTNGPTSFSSVDEVASAAVWGPGLIYVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1QE09</accession>
    <name>N1QE09_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_150592</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758627.1">
        <property type="nucleotide sequence ID" value="XM_016906274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QE09"/>
    <dbReference type="GeneID" id="27903411"/>
    <dbReference type="eggNOG" id="ENOG502QWKV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_299758_0_0_1"/>
    <dbReference type="OMA" id="IDDYEVM"/>
    <dbReference type="OrthoDB" id="5569911at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056703">
        <property type="entry name" value="DUF7801"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029191">
        <property type="entry name" value="Uds1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615:SF80">
        <property type="entry name" value="GRIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25078">
        <property type="entry name" value="DUF7801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15456">
        <property type="entry name" value="Uds1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Up-regulated during septation protein 1" evidence="3">
        <location>
            <begin position="132"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7801" evidence="4">
        <location>
            <begin position="722"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="189"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="909"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="153"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="325"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="421"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="498"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="639"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="801"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="929"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="977"/>
            <end position="989"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF10506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="989" mass="110164" checksum="680DADD404A7EB37" modified="2013-06-26" version="1">MQSTTGGGHQHGQQSVGELESYDGSGYGSPLSSARSSYVNGKPLPTIPAGTHVHDLSQSTNGGYGDFDFDASFPDPPTLPVSAATHAKTNGITHNGSHFDEIRFRLDDPPMGHHIQLNTNVNGEDHDVVGRHLLYETALLDTQSFEILGMGQIDELKKEHARLNSRIEAAERKLALENKMRDAAQNINRLYSSGKRDGRPDTPQSPDKDRHSLLGSRKRTSGSQGAQGLSQAEDELTQSLKKVDELNEQIRTLMDRRLVVERSLLRHTAAVLAEQANKPSETWLANGHRNLDDDDEVLGHAPDGIDEFDGIRDILKGAPAVSTGKAAVQQMQDEHERQLASVREQMQMQHEQTLNSLREKAEQQRREHEREMADMHSRLGRLNTQLRGVITETSQVRGQEPDAELDETPSETAEGALDHTLALLEDNMRAMQQERDKNRTHYARVQDSASETRNAVEQQLESLNSQLHRTLQTSSVMEALQSLEDPPEVTGHGYNFQLQYLEDSLYTLEKLLQEHNEQLEIAKHASSGTREAESTAATHAQRVAEYETVMADLWDIVCAEQKPAGLTSGLSTDATRNSAVSGGSSPIREDFSLQAFSARVQHLFDVASGSKEQQDILRRQIQQQRDLNGKSDMAKDREIQELQTRYEALNSSYDATQQDLAKAVENHIFADQQAQQARQELQVVMSELEQLHSAVNAAEARSRAVDERHALILSERDSLGAERDEHKQRLEDVQNEMQDMESELVRLTTELTMSKAELEGAYGTRKERQKEAGASEAELDALAALKDQEMAQMRREHGEKTKLLEQELQDMMSEFQEMTRESLELEKERGQLENLIDSLRERAEQLEAQLSDTQMQWMGVKSPGGPNGVVKESTSVMVLRQEFKKMMRESRAEGLRLLRAEQEERRRLETEIRKTRQLNSPLGRGPGTRSGSLAHNRLNSLASSHGGTSLMNGTTPATSLGSPPSGHGLPAGLSMGSPLSTQQRAQQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2024-03-27" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>N1QE83</accession>
    <name>N1QE83_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_21783</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757333.1">
        <property type="nucleotide sequence ID" value="XM_016908342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QE83"/>
    <dbReference type="GeneID" id="27905479"/>
    <dbReference type="HOGENOM" id="CLU_2819712_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF09212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="67" mass="6866" checksum="1A2A30C3435609BB" modified="2013-06-26" version="1" fragment="single">DAAAKASVDEVAAGLYAGWPAERRDADAKASVDEVAAGLYAGWPAERRDADAKASVDEVAAGLYAGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1QEK2</accession>
    <name>N1QEK2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EKC/KEOPS complex subunit BUD32</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Atypical Serine/threonine protein kinase BUD32</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">EKC/KEOPS complex subunit bud32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_143489</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759002.1">
        <property type="nucleotide sequence ID" value="XM_016903046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QEK2"/>
    <dbReference type="STRING" id="692275.N1QEK2"/>
    <dbReference type="GeneID" id="27900183"/>
    <dbReference type="eggNOG" id="KOG1187">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_31_3_1"/>
    <dbReference type="OMA" id="WAGHYTS"/>
    <dbReference type="OrthoDB" id="1668230at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="11"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF10881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="260" mass="28866" checksum="96DA7BECB2C53099" modified="2013-06-26" version="1">MDNEIRYPKGFSLEDILAWGSFGLVCLDSSSSTVVKSAHDEQTQPFIDAEKRVYERFDECGGHPGLLKYFGVHDNSIRLEYAPKHDLRSYLQQNGKAIPSRQRHQWALQIAETLVFIHQAGVIHGDLTCSNILLDKELNAKIADFSGSSVDISSSPLLVHVTASHAHPVYTGSAKGDLFALGSLLFEIMTGKSPYDTLTDEEIEERYSRGEFPKTDDSLGLIGEVIRGCWKGMYDSGSMLVEYLTGMRVLAFLLKLNIGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1QEN1</accession>
    <name>N1QEN1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_150837</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759006.1">
        <property type="nucleotide sequence ID" value="XM_016906428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QEN1"/>
    <dbReference type="GeneID" id="27903565"/>
    <dbReference type="HOGENOM" id="CLU_2723834_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF10885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="72" mass="8466" checksum="AA31981C52D519B9" modified="2013-06-26" version="1">MVWRQCWPATSPGNVLTRSRLWLARLWTLLGSESFGVLLSLSVREKTLRERLSWLAVLIQPLIMLFVYKKSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1QEU1</accession>
    <name>N1QEU1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Chromatin assembly factor 1 subunit A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_15053</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759738.1">
        <property type="nucleotide sequence ID" value="XM_016906239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QEU1"/>
    <dbReference type="STRING" id="692275.N1QEU1"/>
    <dbReference type="GeneID" id="27903376"/>
    <dbReference type="eggNOG" id="KOG4364">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013392_1_0_1"/>
    <dbReference type="OMA" id="YENVRPP"/>
    <dbReference type="OrthoDB" id="79480at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033186">
        <property type="term" value="C:CAF-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048800">
        <property type="entry name" value="Cac1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022043">
        <property type="entry name" value="CAF1A_DD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15272:SF0">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15272">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT A CAF-1 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21796">
        <property type="entry name" value="Cac1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12253">
        <property type="entry name" value="CAF1A_dimeriz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromatin assembly factor 1 subunit A dimerization" evidence="6">
        <location>
            <begin position="301"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Chromatin assembly factor 1 subunit Cac1-like C-terminal" evidence="7">
        <location>
            <begin position="545"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="258"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="324"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="517"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="53"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="173"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="342"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="470"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF12253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF21796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF11617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="602" mass="66578" checksum="9A184F81D752DA00" modified="2013-06-26" version="1" fragment="single">TSSVMTAQSIAPESASMSDTGPSAKRRKLTPAEKSEQAQLKETKAREKAKRKAAAEEKKAQAEAEKEERRAQIEEEKARKAEEKRLKDEEKRAKAEEKEAKKREKELEETKKQEEKLAKERKQMRLGAFFGGKPSTPAKRSIDGEEIALLSRQKSLSLEPFDAASAQLKSTTSPVKHSPAPASSKKSNVSDYHKTFLPFEAPTHSQVAPVVRDEQADQARFDHDLNDPLVQEKFDLGLVSSYASLDSYFGELRNARRGKRGHPNIRKVVERAQGTSKEPIDLTEEGSRESPDSILRKVDTKYIHFHEDVRPAYCGTYTKLTSPRTTRRTMRNPFTRSRPDTDYDYDSEAEWEEPEEGEDIGSDDDEEADSNADGDEMDDFLDDEDDKAKSRRKAVTVELIPQSTGLCFANDRGRVLHVDGAQVAVQPPVMDGMRMGFLLPGLSGMTIDPFSTSYWETPAPAHTAANAISSGKSLGTRPSPTAVMAPPRKPLEPRLNFNSSAESAVFALIGAADGQKGPVSSTTAMTPAVKRGRKPQPKALSKEDLDELKAAVVGNQLGKLDLHKALKARFPKLTNDAIKDNLNNLFAQKGSGKEKKWVFVGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>N1QF08</accession>
    <name>N1QF08_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Poly A polymerase C-terminal region-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_51307</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SO2202</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2012-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genome evolution in poplar pathogens from wild and recently domesticated pathosystems.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Dhillon B."/>
                <person name="Feau N."/>
                <person name="Sakalidis M.L."/>
                <person name="Gill N."/>
                <person name="Aerts A."/>
                <person name="Ohm R."/>
                <person name="LaButti K."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Copeland A."/>
                <person name="Beauseigle S."/>
                <person name="Grigoriev I.V."/>
                <person name="Goodwin S.B."/>
                <person name="Tanguay P."/>
                <person name="Hamelin R.C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the TTI2 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016909186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QF08"/>
    <dbReference type="STRING" id="692275.N1QF08"/>
    <dbReference type="GeneID" id="27906323"/>
    <dbReference type="eggNOG" id="KOG2159">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011026_0_0_1"/>
    <dbReference type="OMA" id="TKPGPWM"/>
    <dbReference type="OrthoDB" id="445712at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110078">
        <property type="term" value="C:TTT Hsp90 cochaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052929">
        <property type="term" value="F:ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052927">
        <property type="term" value="F:CC tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001680">
        <property type="term" value="P:tRNA 3'-terminal CCA addition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="tRNA nucleotidyltransferase cca2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3090.10">
        <property type="entry name" value="cca-adding enzyme, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018870">
        <property type="entry name" value="Tti2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13734:SF5">
        <property type="entry name" value="CCA TRNA NUCLEOTIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13734">
        <property type="entry name" value="TRNA-NUCLEOTIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10521">
        <property type="entry name" value="Tti2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81891">
        <property type="entry name" value="Poly A polymerase C-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly A polymerase head" evidence="8">
        <location>
            <begin position="70"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding" evidence="9">
        <location>
            <begin position="284"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="134"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF09632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="921" mass="103104" checksum="0FF73E202F6A124B" modified="2013-06-26" version="1">MSPLVVEEIDDDVANSSSKNIAWEPIELTLKTLLLDVARYIDETPAPPDDADAISQVTVPDVLAKQPIVLRFTGGWVRDKLLGKKSHDIDVAINKMTGYQFGLRLKEYLEIPGNLAKYGLESIASSDKQNQKAGKTDRSKSVGGLHKIEANPEKSKHLETTTMQILGLDIDLVNLRKETYSDEEGRIPQIEFGTPEEDAERRDATVNAMFYNLNEDIIEDFTGKGHDDMRAKIIRTPLAPYQTFKDDPLRVLRLIRFASRLGYTIESSALEAMSNAEIKDALRVKISRERVGTELEKALQGPDPHEALRLIFSLDLYETIYSDPAKAESDHYRPQCEEWKVLIDTLQDIIANGDVLQSELARSQDDGHREEEVMAWQLAALVPYRDAPLPEPSAPGKKAPPPISVQVAKEGIKATNKICDVINASVKNQSEISNLVDELYQKKRRPDKMIEGDDPAARDVLGMAIRRWGTTWRSQVLYSLLVEVANTPDQVEAIERRYATFVQHLRELDVTEACTFKTLMDGKQLAKAIGTKPGPWMKDALDVIMAWQLRNPGSTDLEQVIEEVKNHQAKGELTSDLIRHFLKLTVRPLFIKASPATVTEQGRRVTTERLPAKPTISSTDDSVTKPWKCAKDAYSLDILKWVVHSLDEESVAGVWPLVIPPLLTLVDDWEAKYKTIGADFISALLEATPPSLLERTGLGEVFEQALTPCLTYLPTITEEEESVPLLSSVYPALLSLSRKRFPVVESDTAITMQTPLTQPDRLRIKFLDTVIRKGIIYGYSHCGSTHPALTTVLFDHLAMYLHELKIDCVKHLKFIIPILSEALSNPTGSATVAMLISATNALRAIMRNAWPRMANYRGEILKGLCMCWIKIVDLEGMEVLRAKLQENVKMLEAAMGAEPFFLKELQLLVEADGRLKGLLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFY8</accession>
    <name>N1QFY8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CmcJ-like methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_51858</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757574.1">
        <property type="nucleotide sequence ID" value="XM_016909205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QFY8"/>
    <dbReference type="STRING" id="692275.N1QFY8"/>
    <dbReference type="GeneID" id="27906342"/>
    <dbReference type="eggNOG" id="ENOG502SRIH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042688_0_1_1"/>
    <dbReference type="OMA" id="HEWFYLS"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF3">
        <property type="entry name" value="OXIDOREDUCTASE AN1597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF09453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="31851" checksum="7F796D0DCDD349BF" modified="2013-06-26" version="1">MRDTVLATLRYARGDGEKLLTEKPYILTYPTSEGIPWSNFTIDFHPGIKIHSLRSANLDYNRSGLAMGELESCMPPSDFDDESKIESTYLPAVHRCLQKTLGAKEIYIFDYMIRKRKPEFLKTSPSQDQGPQPALSAHIDYTTKEIEERLQNYFGSKAPELKNRHFQAINAWKPLKGPLRDYPLAYCDASTVNTSTDLMVTDEVFPNIVNEIYQALYSPAHRWYWIPDQTETELAIFVGYDSRQEAQLAVPHCSFDLGHLSEGEPRQSIEVRALVFFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1QG66</accession>
    <name>N1QG66_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SEPMUDRAFT_68047</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760408.1">
        <property type="nucleotide sequence ID" value="XM_016909806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QG66"/>
    <dbReference type="STRING" id="692275.N1QG66"/>
    <dbReference type="GeneID" id="27906943"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_10_1"/>
    <dbReference type="OMA" id="ELTWRVK"/>
    <dbReference type="OrthoDB" id="6692864at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902181">
        <property type="term" value="P:verruculogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000063">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF112">
        <property type="entry name" value="L-ORNITHINE-N5-MONOOXYGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13" id="KW-0408">Iron</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="480"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMF12287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="540" mass="61222" checksum="ECD19301F1FA378C" modified="2013-06-26" version="1">MSSAGSLGGLMAGTLSYWLYFHRFEVHLLGLRILNTFLGCSIALAITLSKAYSYTTAQALATTLAISSSFLIGAYGNCLIFRLFLNPLNKFPGPFAARISSMWWPTQLGNSDGYYWLLEQHQKHGKYVRVGSNDLSIIDPDIMELAYGHKSRVTKAPWYDNDYPLTSMHTSRDKGLHDRRRRVWAPAFSEKALRDYETEIQKFNDKFIRKISEHNGGPANITKWFNLFSFDAMGLLAFGRDYGMLDKGEKPHELEMLDEGMQPLAYRLPSWFFRILTSIPGLAAGYQKFVDFCISELTWRVKNGGKRESDIMGWLLKAYKDVPHPERDTMLQADARLIIVAGSDTTAATFTYMFYHLAQNPECVKKLREELDPLTQGEWQEKDIRGAQYLNGCINEALRLHPPVPSGVNRLTPPEGLTVGDVHIPGNVTFFTPQYVMGRDPSIYTSPNTFLPERWFDASASTTIKHKDAFTPFSAGPFGCIGKNLALMELRTLTTKLVKKFDLKLADHEDGERLLKQTKDHFTVDLGDLEVCFWERGRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGJ3</accession>
    <name>N1QGJ3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_51819</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757789.1">
        <property type="nucleotide sequence ID" value="XM_016909203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGJ3"/>
    <dbReference type="STRING" id="692275.N1QGJ3"/>
    <dbReference type="GeneID" id="27906340"/>
    <dbReference type="eggNOG" id="KOG0682">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_33_0_1"/>
    <dbReference type="OMA" id="QWIFWGY"/>
    <dbReference type="OrthoDB" id="534912at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3430.10:FF:000003">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF15">
        <property type="entry name" value="AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="396"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="10">
        <location>
            <begin position="38"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="456"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="456"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF09668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="483" mass="52123" checksum="8E2F0264C7EBDA32" modified="2013-06-26" version="1">MSTPTTPEFNSSEPWGGDPLTTDVNAQYAGLEYHYTYLVFCGFIVWLIIPGIGLLYGGLARRKSSLSLLFQSLMVASVTTFQWMFWGYSLAYSRTANAFIGDLTNFGMMKVRAAPSPGSAVIPEIVFCLYQMLFCACTVQIVIGGSFERGRILPSLVFAFFWATVVYCPIACWTWNSNGWLYTLPSLDFAGGGPVHIASGWAGLAYAFILGKRRSVGAQSKKKPHNTTLVFLGTILIWFGWFGFNGGSALNASVRAMYAAFNTNTAASCGVLGWVLVDYIRTKGKFSVVGACEGAIAGLVGITPAAGYVSVWLAAVIGFLTAVVCASLQNLNDWLNIDEGLEVFKLHAVGGMMGSFMTGIFADQTISALDGASLYPGGVNGNGIQVGKQLAEISAISAYSFVVTCILLLILKYIPGLGLRVSEEAEMRGLDLDQFFDEQIGDWSYFETFEGNHQVSHSLSPPMLPTSSATSEQAEATKAERKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGJ4</accession>
    <name>N1QGJ4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_49891</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759088.1">
        <property type="nucleotide sequence ID" value="XM_016909138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGJ4"/>
    <dbReference type="GeneID" id="27906275"/>
    <dbReference type="HOGENOM" id="CLU_2086298_0_0_1"/>
    <dbReference type="OrthoDB" id="3650821at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF10967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="117" mass="12788" checksum="9303F315078AFF1F" modified="2013-06-26" version="1">MASAASPQRPGYYQLSAWLACTHSSFANYTAISRFPYVPGPPASSCSRPACKSSVQGRRNKTCDCAIRAAFVSVGIDPKKERLRWHPDRFAGVVGESRRGEFQEAAREIFVVLGGMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1QHA9</accession>
    <name>N1QHA9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolase family 125 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_135818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757530.1">
        <property type="nucleotide sequence ID" value="XM_016902732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QHA9"/>
    <dbReference type="STRING" id="692275.N1QHA9"/>
    <dbReference type="GeneID" id="27899869"/>
    <dbReference type="eggNOG" id="ENOG502QR7D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023537_1_1_1"/>
    <dbReference type="OMA" id="WFAWCNS"/>
    <dbReference type="OrthoDB" id="7771656at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008313">
        <property type="entry name" value="GH125"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31047">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 157 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31047:SF0">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 157 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06824">
        <property type="entry name" value="Glyco_hydro_125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028846">
        <property type="entry name" value="UCP028846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01149">
        <property type="entry name" value="DUF1237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109574" evidence="1">
        <location>
            <begin position="23"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="545" mass="60720" checksum="46E3D757B7D15978" modified="2013-06-26" version="1">MKTPSTAALAVLASLCLKETAALSDKGTSKAKYQEACPAYEHYSKYPHYPFSDGSMALPYQRPSKHCRTFESDLVEKVIKHMTSSLVDHDLARLFENAFPNTLDTTVRWHVDGTEKHTETNGMQQMLGAQPGAWKGPQSFIVTGDINAEWLRDSTNQLAQYQRLAKKDKKIETLILGAINTQAEYVIESPYCNAFQPPPPSKLKASDNGQGDSVHPAYEPSQVFECKYELDSLAHFLRLGNQFYESTGSTAFLTQRWYHALESLLRVLDQQSQSTFDAKTGRFIKQTYRFQRNTNTGTETLNLAGNGNPLNYGTGLIRSAFRPSDDATNLGFFIPANAMMAVELKKTAEMLAAAGKPKVGDELKARGESIEKGVWEHGVVEHKKWGSVFAFEVDGYGSAIMMDDANVPSLLALPYLGFVRKEERTYQNTRKMILSKDGNPYFLQGKAFKGIGGPHIGLNNAWPMSLLVQAMTSDDDDEIAELLEAVKKASPLGLIHESVNVERITDYTRSWFAWANSVFAQTILDIAERKPHLLFKPGTKPYVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1QHC7</accession>
    <name>N1QHC7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS multidrug transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_129509</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764716.1">
        <property type="nucleotide sequence ID" value="XM_016902289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QHC7"/>
    <dbReference type="STRING" id="692275.N1QHC7"/>
    <dbReference type="GeneID" id="27899426"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_0_1_1"/>
    <dbReference type="OMA" id="WIASMFG"/>
    <dbReference type="OrthoDB" id="5410178at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF157">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="482"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="68"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF16595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="534" mass="58280" checksum="9460480FA3B9F46B" modified="2013-06-26" version="1">MSSVDSSSSSPTSSAEKLSDKNNNNNHHHHQHNNDIFEQYGVHLDGDDDDQRVCWNSDAPDHPRNWSPSMKAYTTTIICWLELYMTGISSAGTGAADTARFEYHISRTLAYFAFVTIYLLGQTIGGIVLAPVSETFGRRTLYIVGSFLFCIFSIITAAVPSVAGVYIGRFFQGVAAAIPATVAFGNFNDMYAARTRIGIVYAYTMAGFVGLSLGPVYASYITATCGWRWVFYISAIASAVSAALAFGVKESKADQLLERKVRAIREATGRDDLQAESTSSEGFNFNAFARDSLLRPLKYLFTEPIVIFCAALCGIAFGLLYGLTAGLTVAYTDPPFDKTFSDVSSSLSFIAILIGVLLDVLPRFYDYHLLRRCQTQHLRIVPETKIRSFAIACPALAIGLWIFAWTVPPRVTTVPWPISMIGLICVGFATTDFSYVLFGYVTDSYGDHAASAVSAVSATRTIAAAVFPLFAYQMFSGLGTNIAASILAAVASVFAFTPFLFLTQGQSLRQKSKFAMDDHDCLPEENGHMQDEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1QHG6</accession>
    <name>N1QHG6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="13">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SEPMUDRAFT_144268</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + 4 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 4 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56008"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) + 3 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 3 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56028"/>
            <dbReference type="Rhea" id="RHEA-COMP:14358"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60628"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="13"/>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757580.1">
        <property type="nucleotide sequence ID" value="XM_016903072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QHG6"/>
    <dbReference type="GeneID" id="27900209"/>
    <dbReference type="eggNOG" id="KOG2204">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003818_0_2_1"/>
    <dbReference type="OMA" id="YCANGYR"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000047">
        <property type="entry name" value="Mannosyl-oligosaccharide alpha-1,2-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF101">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 13 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <position position="522"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="343"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMF09459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="535" mass="59547" checksum="59A0E2D0DF7C779E" modified="2013-06-26" version="1">MESIDLGESGDTTPCSSVHYDKQCGVNYDYTGFTQDQNERADAVVEMFRHAWTGYFDYAFPNDDLLPKNNSYRNSRNGWGLTAIDGLDTAIIMEQQDIVDVVLDFIPTVDFTKNNAKGPQDAQTTSLFETNIRYLGGLLSSYDLLKGPFKHLAPDGDKRVDALLSQAVSLADTLKFCFDTPSGIPVNLVWIDNQTFTNSSVMLNGDYTAGLAEIGTLVLEWQHLSDLSGDPSYGELAQRAESYWFQAPEVWPGLTGGNFSVGTGELLDDYGGWTSGNDSAYEYLIKMYVYDPERYSNYSQRWIAAADSTIEHLLSSPNTRPDLTMAGAFSGKVVQNYSEGLACFIGGSFILGSTVLKDDRYLERGLQFAEWCANGYRYAASGIGPVLYSWNETILANPNYTNQTTLYERAGWFIPENLAFVGGQAPEAVESWYYAHQATGDPYWRDVAWAYTLAQNKTLRVGSGFASTSNVLVKDGGEKRNFMASYLLAEVLKYQYLIQAPKQGIWDVIYGEDKVNHFVYNTEAHPMKVAAKKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>N1QHQ2</accession>
    <name>N1QHQ2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_117929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760100.1">
        <property type="nucleotide sequence ID" value="XM_016901385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QHQ2"/>
    <dbReference type="GeneID" id="27898522"/>
    <dbReference type="HOGENOM" id="CLU_1897522_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF11979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="134" mass="14833" checksum="47F5AFBF7539F5D1" modified="2013-06-26" version="1">MDLLSAKSGMTDVKRSAQNPLLHHTNSNKDQAGNNRHYDTSATYVRTRSYSFSTDLERILPRRVAADIEGTMIAVKHEDRGPGRTYRGWHKGRILSGASIAPKRLHKINLEAGIEASASRTDPLTQSTQCGWSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2023-05-03" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>N1QHT3</accession>
    <name>N1QHT3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_70055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758814.1">
        <property type="nucleotide sequence ID" value="XM_016909889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QHT3"/>
    <dbReference type="GeneID" id="27907026"/>
    <dbReference type="HOGENOM" id="CLU_728754_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF10693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="380" mass="43851" checksum="D77E2766356228BD" modified="2013-06-26" version="1" fragment="single">MRHKATTSAKPPLSIYNSTDANFQRIFYHTNNTDNLAHTPSTGQWTHTRLQRERHMMDRTNSESGYEDALEKMPAAAASSATCASPTLHLPFQSRLLNLPPELRLNIYDELMHHVAATSNGVLETHALGYMMAATLKEQGSAFFFSTIIPKCTMVCKQFAREYEDHVLGHTSMTICFAHGIAKNMEALPWRGLAPQRRVFQTIRRFDIQIWSSVAFGCGQPWYDKAVDWLKMQPQQQKEVHGDWTPTKQVFEDLHEFLINFHQLLSPRARLHFSVDVPFFKEAPHMVTKFDLEAFVNMLADSEEEHCPFDQLSISLRHTCYIDMKLDHPEEYWTRRLIENAGGQYEGPEATVSWGSRIAFYEATMIQVGDDVWERGEWEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1QI74</accession>
    <name>N1QI74_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">4'-phosphopantetheinyl transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_150826</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758989.1">
        <property type="nucleotide sequence ID" value="XM_016906422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QI74"/>
    <dbReference type="GeneID" id="27903559"/>
    <dbReference type="eggNOG" id="ENOG502S2QX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089696_4_0_1"/>
    <dbReference type="OMA" id="FTRRILC"/>
    <dbReference type="OrthoDB" id="15433at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="entry name" value="4'-phosphopantetheinyl transferase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00101">
        <property type="entry name" value="AcpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002582">
        <property type="entry name" value="ACPS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="4'-phosphopantetheinyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="4'-phosphopantetheinyl transferase" evidence="3">
        <location>
            <begin position="11"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="138"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="150"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF10868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="214" mass="23726" checksum="E0EC4919F011AE76" modified="2013-06-26" version="1">MPPRPFPFALRIGTDIVSQARLRDLITRPKAGHGTGTQLDAFLRRVFTEREQFVFWKRFAGFHVSNTQRLPLVVSHLAGRWAAKEAAIKAVKPRKVTHRDVEILQDRDTKELYALIQDHPNVLGAPYFRIKHLDLQNNSPAESEEKEPSVPSQGSMPNLESQEQQENPDDSAAQVAKISISHDADYATAVCLAAEDPIPGDVGGEAAARQFSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1QIH0</accession>
    <name>N1QIH0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1479-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_164493</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760350.1">
        <property type="nucleotide sequence ID" value="XM_016908118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QIH0"/>
    <dbReference type="STRING" id="692275.N1QIH0"/>
    <dbReference type="GeneID" id="27905255"/>
    <dbReference type="eggNOG" id="ENOG502QW87">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011148_0_0_1"/>
    <dbReference type="OMA" id="ELNSWWH"/>
    <dbReference type="OrthoDB" id="8249012at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010856">
        <property type="entry name" value="Gig2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613:SF1">
        <property type="entry name" value="DUF1479 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G09280)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YBIU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07350">
        <property type="entry name" value="Gig2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF12229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="432" mass="48419" checksum="EA45776594F186A0" modified="2013-06-26" version="1">MAEQTWPAWPECTVDDAETGDDLVQYKKLIVDKYGQEALTRSWLKTCEELEALTTRVSRLGTAAVPVVQFEDLFMISQERKSELKATGCFKVAGVVAKDQATEWFRNLKQYVAMNKQSIKGWPRETPFILNLYYSPSQMAARSHPNILKLSRELNSWWHSSGEAATDEPLSYADGVRIRPPGVPFPGLGPHIDAGSLARWADPTYQAYYSAVFSGHPEDMDNYDLSLRQNADQAVFSGTAHSTVFRSFQGWTAFSPAAPGEGSLMLYPNVKWQTAYLLLRPFFKPPEDPEDVLDASKWTFDAETPWFPGTSKGDSQLLSPSSHPHLRLKECMVPIPAMEPGDTIWWHADICHAVEIDHKGNNEACVAYIAATPSTEQNKRYMKQQLQDLKTGVPPLDFRHNECANERTFCGFEGEASVLSDEGRRALGFGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1QIT9</accession>
    <name>N1QIT9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Benzoate 4-monooxygenase bphA</fullName>
            <ecNumber evidence="12">1.14.14.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Benzoate-para-hydroxylase A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Cytochrome P450 monooxygenase cyp53A1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SEPMUDRAFT_146209</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>benzoate + reduced [NADPH--hemoprotein reductase] + O2 = 4-hydroxybenzoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18033"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16150"/>
            <dbReference type="ChEBI" id="CHEBI:17879"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="1.14.14.92"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.92" evidence="12"/>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765236.1">
        <property type="nucleotide sequence ID" value="XM_016903518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QIT9"/>
    <dbReference type="STRING" id="692275.N1QIT9"/>
    <dbReference type="GeneID" id="27900655"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_0_1"/>
    <dbReference type="OMA" id="TYDMVRD"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018664">
        <property type="term" value="F:benzoate 4-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000053">
        <property type="entry name" value="Cytochrome P450 benzoate 4-monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF29">
        <property type="entry name" value="BENZOATE-PARA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 16 17" id="KW-0349">Heme</keyword>
    <keyword evidence="7 16 17" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 17 18" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="16">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00072826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00082391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMF17115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="506" mass="57815" checksum="70F8B1C2C6289E3D" modified="2013-06-26" version="1">MFLSFLLTPWAFLVVPVLFYVLPYLRNWSIHDIPGPFLAKFTNLWYMYECRRTRRYLTVNDLHKKLGKFVRVQPDHVSIADPDAIPVVYGHGTGFLKSEYYNAFVSIQRGLFNTRDRHEHTRKRKTVSHTFSAKSVGQFEQYMHHNLELLAKRWDEINEKTGKGKYTEFDALEWFNYVAFDIIGDLAFGAPFGMLEKGADITEVQLTPNGPPTYSPAIEVLNRRGEVSNAVGCWPTIKLFAQYLPDPFFSKGMEAIANLAGIAHARVNQRLAAAERGEIERVDLLARLMEGKDENGNKLGKSELTAEALTQLIAGSDTTSNTSCALLYHCLTKPDVVKKLQQELDQALPSDDVPTYEQVRDLKYMDWVIQETLRIHSTSSQGLPRVVPVGGAEVCGRFFPQGVVLSVPAYVMHHSTEIWGPDAEEFRPERWEKVTDRQKLAFIPFSYGPRACVGRNVAEMELALIVATVFRRYEFELRQSTLETREGFLRKPLGLQVGMRRRNWKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1QIY9</accession>
    <name>N1QIY9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_129224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764363.1">
        <property type="nucleotide sequence ID" value="XM_016902265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QIY9"/>
    <dbReference type="STRING" id="692275.N1QIY9"/>
    <dbReference type="GeneID" id="27899402"/>
    <dbReference type="HOGENOM" id="CLU_426523_0_0_1"/>
    <dbReference type="OMA" id="VGTWDTN"/>
    <dbReference type="OrthoDB" id="3650881at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="435"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="463"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="495"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="514"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="539"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="564"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="607"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="630"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF16242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="642" mass="69964" checksum="B91E4CB552DD2FC7" modified="2013-06-26" version="1">MSARSEPKRGINVPHDRMLSTLVTAAKLLFDASRNPDFTKDSPFALNALRKATSLSKPYLVRLEQELARHNVQTTAPDHRQVRASKAVQFRDVLRKVMKIAQDLTKTRSRRPRESVRLSLLSDVHQYLGLEVARAMREVKRLEHTLEGKHKRHRHRRHRSSTDKPEEHAHHNTGESEGGNAVEISREMVSLTSRASHHAEEEDKHSARPDEVKTTAAQDSVQQVPHDVASLASAASHHTVAAAPPQSPKDIIPAEDAAGSTHTHHTTPAPSVQLNRAQSQTTPELNDREHPHSPPSPSVKTSTHSKEPIANPVSRTTSRHGSPSTRGTPTPPSETSFDRRISAAHARLDSVEKVLASPSRPDPLSEQNLSRHNFSQKSGSSSSKRSKHGSGTKKDGGDERESKLSLAAGSEQLGSSKEEKAGEEESKGKGEVEGGKTTSRGTGSRASSHHSRREEAKIKSGTSVHASHVSSSSSRKGDENKPKSSPSATSEQHGSAKSSSSSSKGKLKVEDGKTTSSHASTSTHHSKLKQATPIQSGTSAHASHASSSSSPSPILPDISKKKTSPPSSTSSTKNSTNNNKVRAQKKSESNIVELPEQEEGEAEEGEQQQQQQQQQQVLSSFTLEQQQQDEMDRERERDRERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJ24</accession>
    <name>N1QJ24_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">4a-hydroxytetrahydrobiopterin dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.96</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_149682</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O</text>
            <dbReference type="Rhea" id="RHEA:11920"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15642"/>
            <dbReference type="ChEBI" id="CHEBI:43120"/>
            <dbReference type="EC" id="4.2.1.96"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pterin-4-alpha-carbinolamine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.96" evidence="3"/>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759926.1">
        <property type="nucleotide sequence ID" value="XM_016905705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJ24"/>
    <dbReference type="GeneID" id="27902842"/>
    <dbReference type="HOGENOM" id="CLU_1256727_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008124">
        <property type="term" value="F:4-alpha-hydroxytetrahydrobiopterin dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.20">
        <property type="entry name" value="Transcriptional coactivator/pterin dehydratase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036428">
        <property type="entry name" value="PCD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001533">
        <property type="entry name" value="Pterin_deHydtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01329">
        <property type="entry name" value="Pterin_4a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55248">
        <property type="entry name" value="PCD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF11805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="220" mass="25052" checksum="5B9C7D52A837531F" modified="2013-06-26" version="1">MSSELSQLQTQGWNAYQEQHLTKFFVFENWTRCLNFAQLVEIDSWSNDHHALLKLSSRSSPQGMRFVATVRWATYKGTPARIEQKDIDSAKRTDAYSVIAKSLGNVSSLQDHPVLQTTRLEEDVALLQSGWVHRDAVISKKFHFHTYTKCRDFVHVIGVECKAKNYHPDIVYFPCWVSIEWRLLVKEKAVALALFCDATASKIGTSANTAEGSHVCMENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJB8</accession>
    <name>N1QJB8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF8212 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_149742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760016.1">
        <property type="nucleotide sequence ID" value="XM_016905741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJB8"/>
    <dbReference type="STRING" id="692275.N1QJB8"/>
    <dbReference type="GeneID" id="27902878"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_138_11_1"/>
    <dbReference type="OMA" id="HEEILTF"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8212" evidence="1">
        <location>
            <begin position="108"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF11895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="437" mass="49860" checksum="18C5952BF0B9D24B" modified="2013-06-26" version="1">MPRVDLKNSKWFTRGWTLQELIAPGVVKFYDCTWTEIGTKIGMIGEIQKITSIDEPVLRDRNKLQSTSVAARMAWAAERVTSKKEDEAYCLMGIFDVNMPMIYGEGMRAFARLQEEIIKTYEDQSILAWQAWEHNQANLLLSPSPKGFRKAHKIVSWSHTWVDDSFDLHNKGLRIYLPVVQDPGDPKRIVAILNCRYSHEIRTQLAIYLREHAPRMIVPSRELKSTVCEMAPQLTDSGTLTALDNIQRAVLYHAKWKSLMILKSPIPPEHIAPGAVWEQKIKIHNLVDQLTLSKVFPPNAYDPHEEILTFFLTGSDEIDRGYMSFLDPDGKKQWSVLLQQESLSGSAKPRVWLCKHGTLADDTALFRTFRASNEELRKIARIEFRKGVQDLVAEVDRDLSQPTKSAWDVKLYLEKKTASSSKGTWTSLVYGSGSKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJN5</accession>
    <name>N1QJN5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">A-factor-processing enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_149815</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760136.1">
        <property type="nucleotide sequence ID" value="XM_016905786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJN5"/>
    <dbReference type="STRING" id="692275.N1QJN5"/>
    <dbReference type="MEROPS" id="M16.008"/>
    <dbReference type="GeneID" id="27902923"/>
    <dbReference type="eggNOG" id="KOG0959">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004639_1_2_1"/>
    <dbReference type="OMA" id="LQSDCWR"/>
    <dbReference type="OrthoDB" id="952271at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000003">
        <property type="entry name" value="Insulin-degrading enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000005">
        <property type="entry name" value="nardilysin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000004">
        <property type="entry name" value="Putative insulin-degrading enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032632">
        <property type="entry name" value="Peptidase_M16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054734">
        <property type="entry name" value="PqqF-like_C_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF18">
        <property type="entry name" value="INSULIN-DEGRADING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16187">
        <property type="entry name" value="Peptidase_M16_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22456">
        <property type="entry name" value="PqqF-like_C_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="7">
        <location>
            <begin position="43"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="8">
        <location>
            <begin position="230"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 middle/third" evidence="9">
        <location>
            <begin position="415"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="domain" description="Coenzyme PQQ synthesis protein F-like C-terminal lobe" evidence="10">
        <location>
            <begin position="810"/>
            <end position="908"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF12015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1120" mass="127791" checksum="4DAF449DB3E4EB8E" modified="2013-06-26" version="1">MNAETVLHSRPEGTRRLADKLEKPLLDNRSYRVIELPNKLEALLIHDPDTDKASAAMDVNVGSLSDPEDMQGMAHAVEHLLFMGTEKYPGENDYNSYLTRYGGMSNAFTAGTSTNYYFELSASSKSNSTKSSANTSKSSLLSVPKEEAPLYGALDRFAQFFVKPLFREDCLERELRAVDSENKKNLQADNWRMMQLTKSTAGKEHPYHLFSTGNYKTLHDDPLARGVKIRDEFMKFYQKNYSANRMKLCVIGRENLDELQQWIEELFLNVPNQDLPKLRWDNVPALTEKELCTQIFAKPVMDQRMMDLSFPYPDEEDLYESMPGRYLGHLIGHEGPGSILAYLKAKGWVTELSAGSSSVCPGTAFFSVGIRMTPQGLENYRDIIKTIFQYIAMLKSEPPHEWITQETAKLAEIEFRFKQKSPASATCSHMSGVMQKPLPREWLLSGQYLIRKYDPEAIIRGLSALRADNFRFTISAQDFKGDMANFDQKEQWYGTEYKLEKIPRDFLQELEAVAQGPHLAELHLPAKNEFIPQRLDVEKKEVASPALTPKLIRNDSNVRLWWKKDDQFWVPKANVYVCLRCPIGYMSAYTVALSSLFKDLVDDSLTEYAYDAELAGLSYDLMRVTTAFEVQVSGYNDKMHVLLEKVLITMRDLEVKDDRFEILKERMMRVYQNFELQEPFRTIGRYTYQLSKERTFSPSELLAELPNITADDLRKFIPSLMRQMHIEIMAHGNVYKEDALRIADMVEKTLKPHPLPPSQWESQRYIELPEGTNFAWQKILKNPNNVNHCLDYSIFVGEASNRQTRAKLLLLDQMLHEPVFDTLRTQEQLGYIVNGSMTILGNNTAFRFLIQSERDCEYLLKRADIFLARFETTLKEMTDKEFEEHRVGIINKRLEKLRNLTQESGRLWHHVVSEVFDFELVYRDVEVLETLTKNDILEMYAKRFSPHSPARSTFATQLVAQSSPADIAAKTTDSEKCEKLADQVLAMLAQGGLQVEPADRTKLVTELEKIDVSTGDVQSILNSIGIWLLAVGLNEESTKMVLAQGAQALPQLLPAAGIIPATEATKEPNGSNEHVDTSGVPEIKRVLVEDVKAWKAGLPLAPIPLPVKDISEFEELEPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJR6</accession>
    <name>N1QJR6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription factor SipA3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_146477</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765566.1">
        <property type="nucleotide sequence ID" value="XM_016903676.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.N1QJR6"/>
    <dbReference type="GeneID" id="27900813"/>
    <dbReference type="eggNOG" id="ENOG502QU87">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001720_0_0_1"/>
    <dbReference type="OMA" id="TKVEWLW"/>
    <dbReference type="OrthoDB" id="10070851at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd07609">
        <property type="entry name" value="BAR_SIP3_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13280">
        <property type="entry name" value="PH_SIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000079">
        <property type="entry name" value="Transcription factor SipA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000349">
        <property type="entry name" value="Transcription factor SipA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039463">
        <property type="entry name" value="Sip3/Lam1_BAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042067">
        <property type="entry name" value="Sip3_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031968">
        <property type="entry name" value="VASt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14248">
        <property type="entry name" value="CYCLIN Y, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16746">
        <property type="entry name" value="BAR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16016">
        <property type="entry name" value="VASt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51778">
        <property type="entry name" value="VAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="317"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="VASt" evidence="7">
        <location>
            <begin position="941"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="523"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="528"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="571"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF17445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1392" mass="153529" checksum="C645D956FD4D941F" modified="2013-06-26" version="1">MPETQAPAADSPLHHLPPSQHQQPVLNLIHVGLREASLDSPTFRCSALHFADNIDAVERWLDGYLKAASRLVAEVSALEAAVNSFLTHSMPPAPISEAVLDHDYTLLATRRYGEGAREVWGNTLRGVKRCDTAVIEPIRGFLNQELRVFKESRRAMDSAQKAFDAVLNRYAAQSKGKEASSLREEAFQLHEARKLYLKASMDFCVQAPQLRASLDQLIVRVFADQWKEMRQGRESSIATFAKWGAEMERVRGWSREMENSERAFKRELLTARRLIEEAAEKKKRPSRELEDYAASTVPYLGTGASSATGAGGSSLDVAEKQGWLFLRTSTARPARTVWSRRWFFVKNGIFGWLVQGTRSGGVEESDRTGVLLCSVRPAFQEERRFCFEVKTKDQSIILQAETQQELTEWINAFEVAKRKALDDPASTETSSAAHGIDPAFAISPPMAPEFAAKIGDGHAAQTSEDLGLGLAAPEREGTGLGVANRTSFDVNPRRVMSLERDAEGGLREASRDHAARLIQKLDLHKRSTASSQASQGSTPGGGGIASLISASHNILPVGPGAADGPKRNFTMPASIQPTSSLAPSTLANPPAATNLSHTAVVVSGERGLNLGRTDGSGVPSGILANLWGSNNWGHINRLGPDDDTSQPSSPRLRAMSISQDDSVVMDGHDASDPNDPLASGLGSVLGHRKNLSVGGEINLPTPRTAKHDAAASVVGDDFPALYPLPLKAQNAQFHTLFPAVPKSEKVVLVFRATWNPNDQQEFPGRVYVTHREIYFFSNHLGLVLITGVSLSTLDEVTAAPGRDCDFIYLHLREGIRQDDARRITIKIFLEPLRLLQRRLNFLVRNARSDEPESLEEILRILIKMESDPLPRRSSVDSWEDVIYEAEDSGQGNLMTPDRRRVRNLKASLRIDGSLYGEAARTGRELQKFKLPAQAVVYAPSGMQSSVSRDFNVSAKALFHVMFGDKSAVFQLLYANRRATNILQTPWTKTDQGHWNRRFTSQDQSLADTQTIDIFNDHLCYVVTSNTQPWRQPYGNSFALTTKFVLTHTAKSRCKLAIFEKLVWHKYPPMPYLKHLIERQAYNSLDADALDLSNVAMDQVAKLGNHSKTNKAVDIFGSVGQQSQAAQIDSSQVPNGALPVIGAAANKPMGIAQLVWNDLFARTLSACSLLLDLMIAVGKGAVSLCNAHTLLVLVLFISALYNGWHAYRDGLVWYHDRSATRFMARIGVAPDAMMTKGVYLNDIVDELLASQSTVNDTLPVQTSSDTGPRRTCRTTFHEQLTTSKSLTRGPSLGVSLQQSRDSLAKYRHDLLVALRVINRIEKDVVSAEFETWVHSEEQKCERVENMLRQLSEKEPNSKGKKAVYMAELGEDFAEYCHSCRIEASSLDTGILLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKE6</accession>
    <name>N1QKE6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ribosomal RNA-processing protein 44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SEPMUDRAFT_35969</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the RNR ribonuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765832.1">
        <property type="nucleotide sequence ID" value="XM_016908625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QKE6"/>
    <dbReference type="STRING" id="692275.N1QKE6"/>
    <dbReference type="GeneID" id="27905762"/>
    <dbReference type="eggNOG" id="KOG2102">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002333_5_0_1"/>
    <dbReference type="OMA" id="GQVMRNN"/>
    <dbReference type="OrthoDB" id="372421at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070651">
        <property type="term" value="P:nonfunctional rRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071031">
        <property type="term" value="P:nuclear mRNA surveillance of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071039">
        <property type="term" value="P:nuclear polyadenylation-dependent CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043628">
        <property type="term" value="P:regulatory ncRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd09862">
        <property type="entry name" value="PIN_Rrp44-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000010">
        <property type="entry name" value="Exosome complex exonuclease DIS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.700:FF:000001">
        <property type="entry name" value="Exosome complex exonuclease exoribonuclease (Rrp44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041505">
        <property type="entry name" value="Dis3_CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022966">
        <property type="entry name" value="RNase_II/R_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033771">
        <property type="entry name" value="Rrp44_CSD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033770">
        <property type="entry name" value="RRP44_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF35">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RRP44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17849">
        <property type="entry name" value="OB_Dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17216">
        <property type="entry name" value="Rrp44_CSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17215">
        <property type="entry name" value="Rrp44_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01175">
        <property type="entry name" value="RIBONUCLEASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10" id="KW-0271">Exosome</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="S1 motif" evidence="17">
        <location>
            <begin position="895"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="338"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00077930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMF17711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="994" mass="111513" checksum="B48B9F65B08BC462" modified="2013-06-26" version="1">MTSLKRSYALTGSSSTTLSSKTYLRTLKSGKVQKVVRELYLRQDIPCSSSLCTECIDIAPAGFHDKREPFVLSATPAATKVYSEGHYLVPDTNAFLNAMDFFEAENTVQDVIVLQTVLEEVKNRSLPLYHRLIALTKNDGKRFYVFFNDFRLETHVARDAGETINDRNDRGIRKACKWYSEHLQKAVAARQSIRCPAIVMLSDDKDNLSKAKLDGIAAANLHDYVSSLADSDRLLDMVASSRDQRAARDAKTQLLYPDYVSVSAMLTGVKNGTMHQGTFSVSPYNYLEGTVHVPSFDRPLIIQGRENSNRAVSGDIVVLEVLPKDQWKAPSSKVIVEEDINKNDNAENEDDSGEGVVSAQERKALRDEVKRAHGKAGEGKPQPTAKVVGIIKRNWRQYVGHIDKDSVKTGAKQSRAQQTVFLIPMDKRIPKIRVRTRQAGDLLGKRVLVTIDSWDRESRYPVGHFVRSLGELETKGAETEALLLEWDVQYRPFPKTVLDCLPAEGHDWKVPADVNDPGWRGRRDLRGELICSIDPPGCVDIDDALHAKKLPNGNFEVGVHIADVSHFVKPNNAMDKEASLRGTTVYLVDKRIDMLPMLLGTDLCSLKPYVERYAFSVLWELDQNADIVSATFTKSVIASREAFSYERAQLRIDDQSQQDDLTQGMRHLMYLSKKLRAKRMAAGALNLASPEVRVETESETSDPVDVKTKQLLDTNQLVEEFMLLANISVAGKNYEAFPQTALLRRHPAPPKANFEELGNQLKTKKGMELRHDSSKALADSLDECVDPQEPFFNTLVRILATRCMMSAEYFCSGTQAYPEFRHYGLASEIYTHFTSPIRRYADLEAHRQLAAAIEYEPIDASLQSRHKLEGVCKNINVRHRNAQMAGRASVEYYVGQALKGRIIEEDGFIMRIFSNGFVVFVPRFGIEGLVRLKDLGDGGEKEPESVFDAEDYSLEINDGKKAGSKFELFQKVTVRISDEAEESTGKRKIKLGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKF2</accession>
    <name>N1QKF2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_146618</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765776.1">
        <property type="nucleotide sequence ID" value="XM_016903770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QKF2"/>
    <dbReference type="STRING" id="692275.N1QKF2"/>
    <dbReference type="GeneID" id="27900907"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021529_2_0_1"/>
    <dbReference type="OMA" id="LEWDRES"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF19">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="336"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="367"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="401"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="283"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF17655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="463" mass="50411" checksum="6A4C1DB01861742E" modified="2013-06-26" version="1">MSDRPHAVLSGRPVVKAGPDSPGEKSRFDVKLNDHGNDILKATAAAAMEASIQTARLQQESNHLVERTRIDSAQSSSNSVPQLPSEKPSGHSVIKASPEIRTSPSRDEARRGASTDSIADSPTLRKHAIPIEEGVNTLPVVQPTSPNREAAAAPASSPTGQSLPSFRQLTGQLGQLTDLAEAATQQDARVPPTLHHHSQSISSASHSPLMAFFPPYPNNAHTSPTAYYQADPRSPASATGEAHQYGSPKQYPVTAYYTDRRRSSAIAETTPIFPPPMPSLPTHSSSGESHGHASSSTDGYSTTHTTPIDGPIPPEGIRRPMLPPPPGMTVVPLEGFRCDYPGCTAPPFQTQYLLSSHRNVHSQSRPHYCPVKECPRSEGGKGFKRKNEMIRHGLVHNSPGYICPFCPDREHRYPRPDNLQRHVRVHHVDRDRDDPLLREVLAQRQEGAGKQRRRRGQSSAPDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKJ9</accession>
    <name>N1QKJ9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_160974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765902.1">
        <property type="nucleotide sequence ID" value="XM_016907916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QKJ9"/>
    <dbReference type="STRING" id="692275.N1QKJ9"/>
    <dbReference type="GeneID" id="27905053"/>
    <dbReference type="HOGENOM" id="CLU_421874_0_0_1"/>
    <dbReference type="OMA" id="FPAFNTS"/>
    <dbReference type="OrthoDB" id="3939858at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="479"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="557"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF17781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="650" mass="62870" checksum="B87665C4545A714D" modified="2013-06-26" version="1" fragment="single">MWYTTYYTAYSLSWASATTVYASSATGVYISNSSSSGTEYGPASSNGNYYTITTTNYTQNYPEGYNVTQITANNTFNAGGTQLSGQTVTSYFSYATGSSSSGSGSNIASNIAGIVTATSAWTSLLSTGVVVSGGGGANGGGNGGQASGVLQTPAPVIISTGGGTAYSTGFAASGVAGGSGGASGTAASGLLPSNATSSVPIITLTSVTSGQTGIVGASSFIGSGVISSSGAGFTPITVISGGSGLSGASSSFDSGIVPSSGSPFTPVSILSSGGGTSGVSSTAASGILPSSGLSITPSSMTSGASGTSGASSSVASGGFSFSNTNGLRSATQSSSATAASGLISSSVPLSLLSTTSTSTPLILTESIPVVTGSVPFSAPSGPRSGTISPSSNSSAPSTTGSSTPPQAFTTTYTESFPIDTTLKLPPFTNSIRSRSGSLFSKTSSIGSGASSFFPSGATSVSLPSLGFPSSTGSVPFNASTGRRSGTLSTSSTFPSSTGSVPFSAPTGSRSGSLPSSGFPAFNTSMPFSAPTGSRSGSLPSSGFPASSTSMPFSAPTGSRSGSLPAPSSSRTAPFGTAPSSSRTFSAPTGSRSGTAPLSFPPFPTASANGSCVTQIMGTMTMFTTVTEYGCYSNCPAGNYGGGPRDSPKTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKW1</accession>
    <name>N1QKW1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_146761</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765951.1">
        <property type="nucleotide sequence ID" value="XM_016903848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QKW1"/>
    <dbReference type="STRING" id="692275.N1QKW1"/>
    <dbReference type="GeneID" id="27900985"/>
    <dbReference type="eggNOG" id="ENOG502S1DF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013056_1_0_1"/>
    <dbReference type="OMA" id="MGIKGAI"/>
    <dbReference type="OrthoDB" id="5407645at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="280"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="364"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="603"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="542"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="94"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="297"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="397"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF17830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="623" mass="68192" checksum="194D111438137BC7" modified="2013-06-26" version="1">MSTYDDDYYEPRRYRSVRTRPRDRDEPDYVREETYIERGKGPGPRGTEMVYRGREESIEDIPRDFPPPGRDRGYDDDDYYDAPRRSKSAGGRGRRSDYDDDRYTDRDVAAAAGAGAGYAAGRRRHRDDRGYDSDYSRSPPRKPERKKSGLEDALGGLGLGGLAAGILGNRDSNRDRSPGGRSTRSRARSRRGYSSSRSRSRGGGGDKNRTERKWAQAAQAALVAGAVEAFRSRNEAGPWTGEKGRRIATAAIGAGGIDGLIDRDPNKKSKRHLAEAVIGGLAANRLANGPRSKSRGRGYDSRDVSPDARSMRSGRSRSRSIIDRLRGRSQSRGRAPSENGGGGGIGTLGKVAGAGAAAVGLKKLYDRARSKSRGRRSPSRDSSADSYVPSRRRPRDQRRSQGSDTGSIRRTDDRDGPGGREVARGSRGVSTIVAGGGGGAKGKGVNDSSDSSSTTDMEKTRKHMRGKELITAGLATVATIHAAHGVYSSMEAHEKRHRLVAEGEMSPEEARKKQTKAWIQDAAAVGIAALGIKGAFSEWKEMNEQRREIQEIEKRKAGRRKKRIARQKQEEMERHERMMNILEKNPQLAVGYQMQQTGYLPNNLGAIPAPDQSGNPYASGPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKY8</accession>
    <name>N1QKY8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AMP-binding enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_137089</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764409.1">
        <property type="nucleotide sequence ID" value="XM_016902826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QKY8"/>
    <dbReference type="STRING" id="692275.N1QKY8"/>
    <dbReference type="GeneID" id="27899963"/>
    <dbReference type="eggNOG" id="KOG1176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_11_1"/>
    <dbReference type="OMA" id="YMRMMRY"/>
    <dbReference type="OrthoDB" id="6614653at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF8">
        <property type="entry name" value="ACYL-COA SYNTHETASE FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="86"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="3">
        <location>
            <begin position="461"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF16288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="580" mass="63632" checksum="915251D060AA8C5E" modified="2013-06-26" version="1">MADYDDRTLHVPPHMSFAALAEKHVLPCHPFFNRLVRLAHAVPPRMCVRDDNTGVEATHLQLLTDALAFRRRIWQILGGHVQKALVQRQEVYVAILAPGGYEFTVAMVAALALGAAVVPMTTALPPEEALYFVTKSRAAALLVSDGALRLGLSVEKLVKNRDPHSPFVCIPVAPSLRNMPLKPAEIIVSSDTYLDDNAAGVVIFTSGTTGPPKGAVMRRAFIYDEAMGVVDHYGITTSDVLLHVLPVHHATGIGIMFFPFLIGGAVIEFKSGSFSPEWLWERWKRGGTTFFSGVPTLYMRLMRYFEQNLALRSDAQQYIDGARALRACICGTSALPKTIADWWTVLLGRQILLRYGMTETGAVFKVRVGDGKVPDGSVGTIQPGSDVRLSEGDQGEILAKSSGMFSRFLFDAEATAASHTSDGYYKTGDIARREGEYYWILGRASVDIIKSGGYKISALDIERELLSLPYIAEAMVVGVPDDEYGERVAAAVVLKSAAEMPSNTHVNIADVVPIAQLRNDLRHRLAGYKLPTVLRIIKDELPKSPTGKVVKKTLSPQYFPGNYRDIPEVQLWSPGIKLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1QL33</accession>
    <name>N1QL33_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Periplasmic binding protein-like II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_126286</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial solute-binding protein SsuA/TauA family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760007.1">
        <property type="nucleotide sequence ID" value="XM_016902052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QL33"/>
    <dbReference type="STRING" id="692275.N1QL33"/>
    <dbReference type="GeneID" id="27899189"/>
    <dbReference type="eggNOG" id="ENOG502QRHZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061316_1_0_1"/>
    <dbReference type="OMA" id="HFNLPWH"/>
    <dbReference type="OrthoDB" id="1363at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd13637">
        <property type="entry name" value="PBP2_Ca3427_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054364">
        <property type="entry name" value="Ca3427-like_PBP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30024">
        <property type="entry name" value="ALIPHATIC SULFONATES-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30024:SF47">
        <property type="entry name" value="TAURINE-BINDING PERIPLASMIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22384">
        <property type="entry name" value="PBP2_Ca3427_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ca3427-like PBP 2" evidence="4">
        <location>
            <begin position="95"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF11886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="312" mass="34682" checksum="53A03A4D9FB4F5D8" modified="2013-06-26" version="1">MAPQKLRIGYVPEHFSTPLAFASNKYYLHADLIPFPTGTGALAASLKVPRNEDGSIDVAIGLTEGFVADLGKSKAEGKHAGYGFVGTYVESPLCWAISTGSKRNEINSVEDLKGKKVGVSRIGSGSYVMSYVLADQKGWLEKGKEPFEEHVPIGDFAALRKSVGQDKSSDFFMWEHFTTKHYWDNGELKRIGEIYTPWPSWMIMARTHENLEAEVEDMMQRINDGVQYYRENKEEAVEHITNHMEYSREDALEWMKTVRFADDVRGVSATTVDTTAAILRKAGVLTDKAGGSEHMIIVGRAEPEVIANPADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>N1QL73</accession>
    <name>N1QL73_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pescadillo homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Nucleolar protein 7 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">NOP7</name>
        <name evidence="3" type="ORF">SEPMUDRAFT_145626</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the pescadillo family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764489.1">
        <property type="nucleotide sequence ID" value="XM_016903167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QL73"/>
    <dbReference type="STRING" id="692275.N1QL73"/>
    <dbReference type="GeneID" id="27900304"/>
    <dbReference type="eggNOG" id="KOG2481">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019619_1_1_1"/>
    <dbReference type="OMA" id="QKVTWIV"/>
    <dbReference type="OrthoDB" id="10264910at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17709">
        <property type="entry name" value="BRCT_pescadillo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03028">
        <property type="entry name" value="Pescadillo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010613">
        <property type="entry name" value="PES"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12221">
        <property type="entry name" value="PESCADILLO - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12221:SF6">
        <property type="entry name" value="PESCADILLO HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06732">
        <property type="entry name" value="Pescadillo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="1" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="298"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="487"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="318"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="508"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="540"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="566"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="580"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="603"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="645"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="660"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="694"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF16368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="704" mass="79375" checksum="833ABD8B1D557EE6" modified="2013-06-26" version="1">MAKIKKRGTSGNAKNYITRSQAVRKLQVSLPDFRRLCIFKGIYPREPRSKKRASKSSTPSTTFYYTKDIQYLLHEPLLAKFRDQKALAKKISRALGKNEVSDASRMERNLTPRMRLDHIIKERYPTFVDALRDLDDALSMLFLFANLPSTSEVPPKIIAKCQRLTMEFEHYLIRTHSLRKSFLSIKGIYYQATLQGQDILWLVPYRFVQKNSPDVDFRIMATFVEFYTTLLGFVNFRLYSSIGLVYPPKFDLKSEEQGAELGAFKLEGRDQDVSEEGQEELADAEVNERAQAEADKLLALPAQEEPGTSQTLGRSTQDEEERADDEDKPTDTALDQFESVDPNADSLLQPSITADVETAAKLFEPFTFFLSRETPKHPLEFILKSFGCKRVGWQSLEGEAGSYCNEDDTRITHQIVDRPDIPLPSPPQTDDEELLDDGVDDSAAIRKANERVPGRTYVQPQWVWDSVNAGQLQRPDLYAPGATLPPHLSPWVKPRQGDYDPTKPLAEQETEAEAAAAEDDSDEDEDEDDVDEGSDGEEVEGVRGDAEAMELKVDLDGRAVAQGEGMDVELGDDDEDSSSAEDGAPADGDFGGFSDNDSEIEDDATRIAREHQAELEAEAAGKKIKSADPKDKKKQAKAVAQAKRTQAEREREEDLERRKGMMPRRKRKMYEKMVYSNAVKSDEAEKMRAKRRKVEKELGKKAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1QLW5</accession>
    <name>N1QLW5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_33498</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764360.1">
        <property type="nucleotide sequence ID" value="XM_016908541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QLW5"/>
    <dbReference type="STRING" id="692275.N1QLW5"/>
    <dbReference type="GeneID" id="27905678"/>
    <dbReference type="eggNOG" id="KOG1290">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_81_7_1"/>
    <dbReference type="OMA" id="KLLRCQV"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:protein serine/threonine kinase activity"/>
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    </dbReference>
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        <property type="term" value="P:regulation of mRNA processing"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
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    </dbReference>
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="39"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF16239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="213" mass="24223" checksum="6785C69089ADE6EE" modified="2013-06-26" version="1">MATSATTSHSKPIEEETLPDYDAEHFYPVHIGDTLNARYSVLGKLGYGVTSTVWLRLHIRPSLLFLAVSMYCQIFRDSSYVALKVYVRTSPDQANLEETVNRHLSGLSTSHPGCFNIRQSLDVFYLHRANGFRHYCIVHEPLHATMSQFQRLHGTARPLPEVLVKYFMQYLLQGLDFLHTEASVAHCGSLFRPISSGNLRSPERHDSCWKILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>N1QMY7</accession>
    <name>N1QMY7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_113755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765898.1">
        <property type="nucleotide sequence ID" value="XM_016901050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QMY7"/>
    <dbReference type="GeneID" id="27898187"/>
    <dbReference type="HOGENOM" id="CLU_863729_0_0_1"/>
    <dbReference type="OrthoDB" id="3634722at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109998" evidence="2">
        <location>
            <begin position="19"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF17777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="322" mass="32868" checksum="46C10AD22A230767" modified="2013-06-26" version="1">MYLLHFIAIALLAVLAIATPISSADPQGQFDDASLLGMTPTSTGLAATALRDLPTSGPCKAFYFDPKDNVPCGSVARQFMIYLSYPEYDQTSTSEWCEVFLQSNGICRATSPNSPSAFPTPRASTLSISTLIPTQTSVATISDMASTTRMNATATCSSVIATVSVNGATASPVSPGSNSTMSTSTAAPSSTNINTTAATGPITSTTSRYSVVLASERESLYSASVLGLGITPNASTLSESVTTSTGLSTESNGPSASSPASSSAVANSTNPIVRITTRVVSFTIDGGNRTSLMTALVNAYVVANATTTAIPIRSSAVTSATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNE2</accession>
    <name>N1QNE2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_57388</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765330.1">
        <property type="nucleotide sequence ID" value="XM_016909431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNE2"/>
    <dbReference type="STRING" id="692275.N1QNE2"/>
    <dbReference type="GeneID" id="27906568"/>
    <dbReference type="eggNOG" id="KOG0936">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061221_2_0_1"/>
    <dbReference type="OMA" id="DLIFNWQ"/>
    <dbReference type="OrthoDB" id="10261046at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000001">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="7">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF17209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="183" mass="19993" checksum="02DA3D91248694DB" modified="2013-06-26" version="1">MINAVLVFNNHGQPRLTKFYTQLDTAVQQRLISEIFTLVSTRPNSACNFLPLPPLLAPAPSSSTAPASAPEHNDAPSLVTYRHYATLYFILISTSTESPLALLDLIQVFVEALDRLFENVCELDLIFNFETLHAVLGEMIVGGVVIETGLDRVVEGVKSQGRVAKRPVNESRAGLGATMWAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-12-14" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNQ1</accession>
    <name>N1QNQ1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_104722</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765595.1">
        <property type="nucleotide sequence ID" value="XM_016900550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNQ1"/>
    <dbReference type="GeneID" id="27897687"/>
    <dbReference type="HOGENOM" id="CLU_1215438_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF17474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="228" mass="24825" checksum="1323DB2FC860E761" modified="2013-06-26" version="1">MLSSHVEHVRWLENEGMSAEGAGDEGENTRMRYTHVGSGAGGRCGQCALQRDHTDMKCSIPCHDGRPPPSATCLAKRRTMYLLDLAIADSTSLGTNYELLPSNPAAVPPRGDPASCPALYLQPPDVFNSLSQQARREGHACMLTDLQSCLPNLLYHLTLLTLTVPRISLLSTRKQKRLTSHITHSTTAMDNPKVLHELDNGFVVRAWVRSNNLIASTNDVLTAGGAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNS4</accession>
    <name>N1QNS4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">SEPMUDRAFT_78915</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">ATP-dependent RNA helicase associated with the nuclear pore complex and essential for mRNA export from the nucleus. May participate in a terminal step of mRNA export through the removal of proteins that accompany mRNA through the nucleopore complex. May also be involved in early transcription.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Associates with the nuclear pore complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the DEAD box helicase family. DDX19/DBP5 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF18018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016766139.1">
        <property type="nucleotide sequence ID" value="XM_016910207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNS4"/>
    <dbReference type="STRING" id="692275.N1QNS4"/>
    <dbReference type="GeneID" id="27907344"/>
    <dbReference type="eggNOG" id="KOG0332">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_1_0_1"/>
    <dbReference type="OMA" id="IAAETRW"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000822">
        <property type="term" value="F:inositol hexakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006415">
        <property type="term" value="P:translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17963">
        <property type="entry name" value="DEADc_DDX19_DDX25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000849">
        <property type="entry name" value="ATP-dependent RNA helicase DBP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="11" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0811">Translocation</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="20">
        <location>
            <begin position="115"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="148"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="329"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="16">
        <location>
            <begin position="115"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EMF18018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="518" mass="56929" checksum="742C1E57A60EFDEE" modified="2013-06-26" version="1">MSSTTEPDAVKLDGLNLKDDKPSNGTKPNPGAAAFSPAGPGFKWSDEDDSTATTAGTDKKAGSEEAKKSGLEKSQTDGATGWLNGAKGLDEPEFDVNVKLADLQEDPNNPLYSVKTFDELNLRPELERSLAIMNFVKPSKIQERALPLLLKEPASNFIGQSQSGTGKTAAFVLNILQRIDPSSNKPQALVLAPTRELAKQIAGVALLMGAMLEEKGLKVFEAVPDPAKRNLQVDGQVVVGTPGTVMDMLKRRLLDSRQIKILTLDEADNMLDMQGMGDQCKRVKQQLPKTTQIVLFSATFPPEVLAFAEQFAPKSNMITLQVEELSVKGIKQMYLDCQNDEEKYAALIKFYGLMTIGSSVIFVKRRDTAVEIERRMVAEGHNVASLTGAKEGAERDDTFRKFREGEAKVLIATNVLARGIDVSTVTMVVNYDIPETVDGQPDYETYLHRIGRTGRFGRTGAALTFVHDRKSWQGLMAICKHFGVEPTKLDTNDWDEVEHKIKTIMRNSRNAVGDFDMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNY1</accession>
    <name>N1QNY1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATPase, V1/A1 complex, subunit E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_32068</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase E subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765930.1">
        <property type="nucleotide sequence ID" value="XM_016908481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNY1"/>
    <dbReference type="STRING" id="692275.N1QNY1"/>
    <dbReference type="GeneID" id="27905618"/>
    <dbReference type="eggNOG" id="KOG1664">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073641_0_0_1"/>
    <dbReference type="OMA" id="QHMMAFI"/>
    <dbReference type="OrthoDB" id="10263003at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2320.30">
        <property type="entry name" value="ATP synthase, E subunit, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00311">
        <property type="entry name" value="ATP_synth_E_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038495">
        <property type="entry name" value="ATPase_E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002842">
        <property type="entry name" value="ATPase_V1_Esu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45715">
        <property type="entry name" value="ATPASE H+-TRANSPORTING V1 SUBUNIT E1A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01991">
        <property type="entry name" value="vATP-synt_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160527">
        <property type="entry name" value="V-type ATPase subunit E-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF17809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="232" mass="26572" checksum="5D2A4E2D8CF30362" modified="2013-06-26" version="1">MSQIHAMSDDQVSNELRKMTAFIRQEALEKAREIHLKADEEFSIEKSKLVRSETSRIDSEYQKKFTQAGMSQQITKSTLANKTRLRILSARQELLDQLFEDAHKKLGENATKDKGKYEKVLKDLILEGLYALVNEKKVTLRCRKKDDDVVKKAAEKAKEEFKKSMKNDVEISVDDKERVPENSAGGVIILNSTGKIDINNTFEERLHLLETDGLPAVRATLFGENKNRKFKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNY7</accession>
    <name>N1QNY7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Exportin-T</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Exportin(tRNA)</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA exportin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SEPMUDRAFT_146770</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
        <text evidence="11">Shuttles between the nucleus and the cytoplasm.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the exportin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765960.1">
        <property type="nucleotide sequence ID" value="XM_016903854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNY7"/>
    <dbReference type="STRING" id="692275.N1QNY7"/>
    <dbReference type="GeneID" id="27900991"/>
    <dbReference type="eggNOG" id="KOG2021">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004414_0_1_1"/>
    <dbReference type="OMA" id="HEMFLFG"/>
    <dbReference type="OrthoDB" id="26399at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071528">
        <property type="term" value="P:tRNA re-export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000355">
        <property type="entry name" value="Exportin-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045546">
        <property type="entry name" value="Exportin-T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040017">
        <property type="entry name" value="XPOT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15952:SF11">
        <property type="entry name" value="EXPORTIN-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15952">
        <property type="entry name" value="EXPORTIN-T/LOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19282">
        <property type="entry name" value="Exportin-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="6 11" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Exportin-1/Importin-beta-like" evidence="12">
        <location>
            <begin position="104"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Exportin-T C-terminal" evidence="13">
        <location>
            <begin position="344"/>
            <end position="1021"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF19282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMF17839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1024" mass="114193" checksum="17A34B952FA48CE4" modified="2013-06-26" version="1">MDTQVESAIELAFNPTTEHNLKGQAYDFLNVLKQDPNAWQVCLALFTRHPSPSEVVRLVCLEIVNNAVQTQRLDQAGLNDVRYRLMDYVRRRYSSTSTEADTPTIQNKVTQTLTYLFTSLYASDWTDFFDEFIALASSSSETSSDGAQAPTVLLLRILGSIHDEIADVMIPRTPEEARRSAELKDLVRTRDVNKIATIWQDILSNWTQLDLGIVEMCLRTIAKWVSWIDIWLVINERIQGALLEIAGQQGSLTTASREAKARDAAIDTFTETVGKKMQPNDKVELINYLNLGSIVGQLVASPALSDLRKTSDYDTDLAETVAKLVNNVVFDVVKVLDNDSIEAQTRTKADQQLQTFVPYLLRFFSDEYDEICSAVIPSLTDLLTLFRRLNKVKGGLPSHYSGMLPPILDAIVAKMKYDDTASWGDEDEQTDEAEFQELRKRLHVLQQTVAAVDESMYMDNLTRVVANTLGRLGTEDRPNWRDLDLALLEMHHFGELAIRNGGLYNKSKPTSEAASRLVEMMSTLVASDLATYPHPAVQLQYMELCVRYVQYFEQNIAGIPKVLENFVTFIHSDHNKVRLRSWYLFQRFVKHLRAQLGEYAQTIVQAVSDLLTIKAELPTDKDEDDDSSSDGVSTDAAFQNQQYLFEAIGQVSSTQNVPTPTKVAIAKTVIEPLSLDLSNHLPSARNGDERAILQVHHVIMALGSLANGFSDWTPGAPTSTPPPAELAKEFESAGETVLLALENLKHNSELRAAARHAFSRFLGVLGAQVLPQLPRWIEGLLSSASSNDEMAMFLRTLGQVVFGFKTEIFAILDQLLTPLLQRVFAGFSQEITGTDDEIQLRELRREYLNFVLVILNYDLASVLVTPANQGIFDTFVTSITRFSCDISDAQSARLAFSVLTKMTSIWGGPDLSNFSASEAVAQPTLPGFDSFILTQFAPLPWALVSTQGFSPHDAQMRTVLQEAGVLQWTILRKNGLAYQTQLQNELRNLGVGDDGIQSYLTSISGDALAFRKFFSSFVAQAAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M3ASQ0</accession>
    <name>M3ASQ0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acyltransferase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_74254</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756650.1">
        <property type="nucleotide sequence ID" value="XM_016910057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3ASQ0"/>
    <dbReference type="STRING" id="692275.M3ASQ0"/>
    <dbReference type="GeneID" id="27907194"/>
    <dbReference type="eggNOG" id="ENOG502SHP9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005679_13_3_1"/>
    <dbReference type="OMA" id="PYDPNLW"/>
    <dbReference type="OrthoDB" id="5405781at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050879">
        <property type="entry name" value="Acyltransferase_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028:SF134">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="254"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="409"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="3">
        <location>
            <begin position="64"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF08529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="509" mass="58385" checksum="923EFF75187E8C81" modified="2013-05-01" version="1">MSSSSLLPSSPNERTEKPPNNPPRKSTTTLILPTLQTSLSTIGHFLLPECLIVHSPPQVLHETSWLDGLRGVAALLVVLQHEHAMVNMGLHRCYGYGHDDETRSLAYWPVVRLLFSGGSFAVMVFFYISGFVVPRRMIQMLHEGRQTEYMEALQSAIIRRHVRLLMPAFFSALLIIVFYHITGFEENWSGGRASNIFVEFLWWILDCLHTLNYFTAFAMRYNPVTWTIVVELKGSMAIFAWLFVVHRLRPQRRILLTLALSFFLVLFGLGSWFAAFFVGMLSCELDLLNASGELTHIWLPWTKISHYLAQHKRLHALVLNAGIILGLLFASTPMLKGPSAKEAIERCAWPETLFNIVPYHYWQNWPTLEYRDFWYFWGACLLGISIKEVKWAKSLFETNFAQYLGRHSFSLYLTHLVVGATFSRIIFILCGYSHLGGPDANWPFDRIAVGAWHDYFPASVGPQGLTPGIILNLMLTLPVMFFVAEMGTKVFDRPSVRLSQWVWEWYQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M3AT96</accession>
    <name>M3AT96_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_151690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756860.1">
        <property type="nucleotide sequence ID" value="XM_016906982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AT96"/>
    <dbReference type="GeneID" id="27904119"/>
    <dbReference type="eggNOG" id="ENOG502SQTP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036220_0_0_1"/>
    <dbReference type="OMA" id="ISTWRCT"/>
    <dbReference type="OrthoDB" id="25896at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="648"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="274"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="651"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF08739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="687" mass="75585" checksum="FBED87AC0595E6A4" modified="2013-05-01" version="1">MAALTDSARADMAVSITTCLDATKQAFYDGSAILDKIKRKRALKRAPPPPRLLEESIDAAPDEIEKEKQRGLARFGKAFQEGDHIAIIQLQQVTIQLQASLLEKLRHAAFDDDYAITDFTYLVDAADGGRDKTIAVLHEFKQRLIHGTSREDFHSPHSSRTELGVHTPTQTPPLQPPVAEIPLKSRSERTLSQPQPPLSFQHPAQRPSELKKHPTWQRDFRVSPSDDGDATSGAEEVQDVQQRHKKRNSLLHFLKHTRTNSTTDKNLPDAIAEATAPTSTASSTATTTTTVPLALRPSEDLGARHSHDRPTRDRSNTASSHVTNNNNNGNNSTATREARFTYEDWEDNPSEIWGARPSPNERRETLSLAPNATSSSDIENFTALHHAISNTNSLAPPSSPNLTLNGVRTASIAPSFASFGAGMAAGLGASNSHASGGAATAPQPCPDNEFLGLCKSSWKLQNGDKKGAFTAHKQVEPWSRHPGVYAAAPYFLACNAKSCLFRSSHAHTDVELIWRRVFTSSAKGIRVRWRFLAKSHVVQKVVVKGQFSFKCLFCVFLGVVQGGGGVYHGIDLYLDHINYAHRGQKLNDVVLYKTGCVMDRVADDGEDFDINLWPGYGNAVIPCAGIKGEVQSRQKDGTEWLSDDLLMGDPSKSHNGRDDSMFSANEPWNEGLSDFHYRGEYDRTELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M3AUV8</accession>
    <name>M3AUV8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP phosphoribosyltransferase</fullName>
            <ecNumber evidence="5">2.4.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SEPMUDRAFT_150967</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP</text>
            <dbReference type="Rhea" id="RHEA:18473"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="2.4.2.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATP phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.17" evidence="5"/>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF09856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757977.1">
        <property type="nucleotide sequence ID" value="XM_016906509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AUV8"/>
    <dbReference type="STRING" id="692275.M3AUV8"/>
    <dbReference type="GeneID" id="27903646"/>
    <dbReference type="eggNOG" id="KOG2831">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038115_1_2_1"/>
    <dbReference type="OMA" id="ITAKKYV"/>
    <dbReference type="OrthoDB" id="2574at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003879">
        <property type="term" value="F:ATP phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd13592">
        <property type="entry name" value="PBP2_HisGL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.120:FF:000003">
        <property type="entry name" value="ATP phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000123">
        <property type="entry name" value="HIS1p ATP phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00079">
        <property type="entry name" value="HisG_Long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020621">
        <property type="entry name" value="ATP-PRT_HisG_long"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013820">
        <property type="entry name" value="ATP_PRibTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018198">
        <property type="entry name" value="ATP_PRibTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001348">
        <property type="entry name" value="ATP_PRibTrfase_HisG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013115">
        <property type="entry name" value="HisG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00070">
        <property type="entry name" value="hisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03455">
        <property type="entry name" value="HisG_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403:SF8">
        <property type="entry name" value="ATP PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403">
        <property type="entry name" value="ATP PHOSPHORIBOSYLTRANSFERASE ATP-PRTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01634">
        <property type="entry name" value="HisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08029">
        <property type="entry name" value="HisG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="GlnB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01316">
        <property type="entry name" value="ATP_P_PHORIBOSYLTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 17" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP phosphoribosyltransferase catalytic" evidence="15">
        <location>
            <begin position="59"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine biosynthesis HisG C-terminal" evidence="16">
        <location>
            <begin position="242"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMF09856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="318" mass="34553" checksum="3EC16ADD39E03561" modified="2013-05-01" version="1">MDLVNHLNDRLLFAVPKKGRLNQAVLDLLAGSDIQFHRHNRLDIALVKNHPVALVFLPAADIPTFVGEGRVDLGITGRDTVAEHEAVTPATETHGIEEIMDLEFGRCKLQVQVPEKGDIQTPEQLVGRNVVTSFTGLTEEFFRKLENNDSQANGSTPGDSSEKPKLRTHIKFVGGSVEAACALGVADGIVDLVESGETMRAAGLKAIATVVESTAVLIRSKHPSDPKLVDIIANRIRGVITAQKYVLCTYNVERKNLDRARSITPGKRAPTVNSLEEEGWVAVQAMVLKKAIADVMDELQSIGATDILVTRIDNSRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M3AWA0</accession>
    <name>M3AWA0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ClpP/crotonase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_126632</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759136.1">
        <property type="nucleotide sequence ID" value="XM_016902089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AWA0"/>
    <dbReference type="STRING" id="692275.M3AWA0"/>
    <dbReference type="GeneID" id="27899226"/>
    <dbReference type="eggNOG" id="KOG0016">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_2_1"/>
    <dbReference type="OMA" id="LHCDFVY"/>
    <dbReference type="OrthoDB" id="448450at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004165">
        <property type="term" value="F:delta(3)-delta(2)-enoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051053">
        <property type="entry name" value="ECH/Chromodomain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684:SF1">
        <property type="entry name" value="ENOYL-COA DELTA ISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="246"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF11015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="278" mass="30334" checksum="2D2799FBEC27F4F2" modified="2013-05-01" version="1">MTVSPPSLDNISVTVDSQQPAIALIKFNRPKNANALSVPLVNDYLSALRWTEQESSIRIIITTGEGKFFTAGLDLLDPSVKATPGATVSDGFISGLSAVHEHLIKTDKLLISAVNGPAPGWGTTHIALSDLVYATPQAFFFTPFVQWGLCAEGCSSLTFTKILGRQKASALVLAGQRMSAEELERAGLVTKVLPQEGFLDGVFDLARQVARLPAESLKFNKQVMMRTEREELLKCNRVEMEALKEQARKKESSDAIRGFAEETERKKREKKAAGGSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M3AY84</accession>
    <name>M3AY84_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">DNA repair protein REV1</fullName>
            <ecNumber evidence="13">2.7.7.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SEPMUDRAFT_149122</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Binds 2 magnesium ions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="13"/>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760573.1">
        <property type="nucleotide sequence ID" value="XM_016905356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AY84"/>
    <dbReference type="STRING" id="692275.M3AY84"/>
    <dbReference type="GeneID" id="27902493"/>
    <dbReference type="eggNOG" id="KOG2093">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003901_1_1_1"/>
    <dbReference type="OMA" id="IKNGMWM"/>
    <dbReference type="OrthoDB" id="427711at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017125">
        <property type="term" value="F:deoxycytidyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01701">
        <property type="entry name" value="PolY_Rev1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.100:FF:000001">
        <property type="entry name" value="DNA repair protein REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000040">
        <property type="entry name" value="DNA repair protein REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1630">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1280">
        <property type="entry name" value="DNA repair protein Rev1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025527">
        <property type="entry name" value="HUWE1/Rev1_UBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053848">
        <property type="entry name" value="IMS_HHH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012112">
        <property type="entry name" value="REV1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031991">
        <property type="entry name" value="Rev1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038401">
        <property type="entry name" value="Rev1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21999">
        <property type="entry name" value="IMS_HHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16727">
        <property type="entry name" value="REV1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14377">
        <property type="entry name" value="UBM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036573">
        <property type="entry name" value="REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 13" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="10 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BRCT" evidence="16">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="UmuC" evidence="17">
        <location>
            <begin position="302"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="136"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="694"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="853"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="927"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1004"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="709"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="401"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR036573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR036573-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMF12452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1138" mass="125217" checksum="6899BBE937082FE3" modified="2013-05-01" version="1">MVTHIIASNLTRKKKEEFKRYRIVKPAWVVDSIKAGKLLPWDTYRVVDEGVAQKVLGFDNGQVVSQVNKATRGYREQTDASWYTSQLRGSQSTAPSKPPLLTQTVTPDIEEIDDDDEFGLPDITSSVEQALNEAENLPTDQDDGGSRAPEVAGGPQTPPPTSPMSPPQEEAKVEIEAQSPEAIEPEPPPGHQSVLRPREGSQEPDYTHSLIRNSEVLKNISPTKLAAMTAEEHNALILSDPKIRKSTVVHPDFLEQYYRESRLHHLSTWKADLKSQLQALASEKSSSQKAKQKRQPGQRRYVMHVDFDSFFAAISLKKCPQYKDKPVAVAHGGGSGSEIASCNYPARKFGVSNGMWMKRAQELCPSIKILPYDFPGYEDASRKFYDAIMATGGIVQSVSIDEALVDISVMCFTGSGTDGVRRDEGAVHREQSRADEIAQALRDEVLQKTGCAVSVGIGANILQAKIALRKAKPAGQYQIKPDDVLEFIGQLEVQKLPGVAWSIGGKLEEIGIKLVKDVRETSKEKLINTLGPKTGEKIYEYARGIDKTEVGEQVVRKSVSAEVNWGVRFENQEQVDEFMSGLCGELHKRLMKERVKGRQLTMKVMKRAADAPLDPPKHLGHGKCDVFNKSLQLGVATNDHALIAREAIALIKSFNISPGELRGIGIQMQKLDQIKVGAEGADQGSQRRLQFKAGPGFSKAAPSVPPVVPRDDIQDEGHTPPKKRIAEANKPSAAFRPANPGTPSKKPLNVLGTQFVLPTQVDPAVLAELPEDIRAKLARQVHVKAGVEEVEEAPPAPEVIPKLRLADTKDSLPPSRAHSPATIVPPQSQLDLSILNALPADLRAEVLGFYKKPQAGPSRQGDQCVLPQSPRKNRTLPPPPPVVKRGRGRPKGAKNLTSRLRKVANDRSTLTQSNFIAHSAPIPAISEAVASHSSKKSASEVEEEQQLDPEVLAALPAELRKEILAQQRQERLQRTGGIDTSLHQRPKKNSWLNVNNKKETSIVVTDSDSGLPEQHPQRQQHSFLLPPRPPQPTFTSQKLSTLPELRSAISAWFQEFQDEAPFVEDVDALITYLKAVVLDERDLDKAVKLVKWMAWVIEEHGEDVPEDVLNGWTDALGRTRSGVQDAARERGLGCVVFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M3AYI8</accession>
    <name>M3AYI8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS multidrug transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_44801</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760728.1">
        <property type="nucleotide sequence ID" value="XM_016908944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AYI8"/>
    <dbReference type="STRING" id="692275.M3AYI8"/>
    <dbReference type="GeneID" id="27906081"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_0_1_1"/>
    <dbReference type="OMA" id="CAYLTDT"/>
    <dbReference type="OrthoDB" id="5410178at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF157">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="462"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="493"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="84"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF12607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="551" mass="60747" checksum="A338B6DFCCFAF3AE" modified="2013-05-01" version="1">MDDKHTHSVRVSSSSEHASTLHWSAESRTPSPPSSILSGDTRVAIPRNVVELLEQKQLDVDSNGVVHWQEDSRTHPRHWPVWRKTFDSGVICLLEFFTTLISNTGSSVARYASEDVHISNELSIFCFVTLYLFGQALGGLVFPPIAESFGGRTIYLFGAAGFSISCLIVGASPTLPAVIVGRFMSGLFSAMPTVVAVGSIENMWDAKGRIWVIQLWVMVAIIALALGPPIATYVSESSIGWQWVYYGAAIGNSFIMLMCFYMRESRPALVLRHHVHLIEKATSFKGLALDDDLRLPTIREFTQHNLILPLRLWFTEPLVFLVALMAAVSFGFIYLFAEALHVVYHVNFGMNEKESSLTFLAIGVGVCLTWIPRLYDVHLYNVEKKTGVAVEPEKKLLGYYVAAPILAAGLWWFSVTVPPLVSNITIWASIVSLVLVGYGVVEFDSVLCAYLTDTYTSYAGSANAPVAFLRAVLSGVFPLFAPKLFKGLGANNALFLLAGIATAFCGVAIGFRFYAKRIRERSPFAGKLMGNEQGKPLEMKVQRTIIVSRQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>M3B028</accession>
    <name>M3B028_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_125005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761268.1">
        <property type="nucleotide sequence ID" value="XM_016901946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B028"/>
    <dbReference type="GeneID" id="27899083"/>
    <dbReference type="HOGENOM" id="CLU_3107930_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF13147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="51" mass="5800" checksum="8BBE1C3C78E15121" modified="2013-05-01" version="1">MFQDFTPDSVATAETPSTRVTARTRYIIIQQMMSARERALYKASRTSGEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M3B1Z1</accession>
    <name>M3B1Z1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Pkinase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_148981</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_016905265.1"/>
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    <dbReference type="GeneID" id="27902402"/>
    <dbReference type="eggNOG" id="KOG0575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_46_0_1"/>
    <dbReference type="OMA" id="SPWIDFY"/>
    <dbReference type="OrthoDB" id="408964at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="term" value="C:kinetochore"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:spindle pole body"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="CDD" id="cd13118">
        <property type="entry name" value="POLO_box_1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="POLO box domain"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
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    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
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    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
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        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF0">
        <property type="entry name" value="CELL CYCLE SERINE_THREONINE-PROTEIN KINASE CDC5_MSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00659">
        <property type="entry name" value="POLO_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82615">
        <property type="entry name" value="Polo-box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
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    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ST"/>
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    </dbReference>
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    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="23"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="421"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="523"/>
            <end position="583"/>
        </location>
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        <location>
            <begin position="423"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="477"/>
            <end position="489"/>
        </location>
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            <begin position="523"/>
            <end position="540"/>
        </location>
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        <location>
            <position position="56"/>
        </location>
        <ligand>
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        </ligand>
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        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="EMF13807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1035" mass="113836" checksum="6C4CD9137668F0DA" modified="2013-05-01" version="1">MSSNSIHADPPPPVVTEPSGISYATGGALGKGGFAICHKAERYDGSRPTGQIFALKIVKTRMEPAKLAQKFVTELQIHSKLSHPNIVTFHRAFSFQTSTYVVLELCPNGSLADMLKKRKQVTLPEIRRLVIQVCGAVKYLHHRHIVHRDLKTGNLFLDDRMNVKVGDFGLAALLVTERDMEVRRRTTMCGTPNYLAPEILEKGKGHDEKVDLWAIGVIAYTLAVGKAPFHASTKEEIYKKLRSGTYTWPELSATTNQSADLRDLVSSILVEEHQRPNPDAIVSHKFFKVAYVPAEIPKSARTEVPKWEVSIPSAETIRRGYSETWFSVCKESGVGEYEEGRCFPLNGGRKIRSIVHDMEKETQLGRQPMMPIPKDVVYTSMISDFEKTSPDSSAASVELPRKNFASRHMREMSHNEVAMPRFRATDTGKAARDTELMPPPRAPSRAARAPGTNSVRRAARTISEETAAKSSESVKIASDSSSSGPSSAAPVRVAKTRPAPVPSSSAPATVTVASALRESKNFATGTTTSHQTLPAEQSSDPLEKPQRSGTVKRSADASLARRPRAPRPAQERPSSPEELQLPAQPNVAKVARKRNVSQPVEQGPLATLDELKQVEPFKSRRKAPAAEVIEILSDPDSDDRDELKKPVESISATLKLPRPPRMTARLPQPRRKLHDEMEPAVPGTDPTAVLKKLAILRDNLAEALTRSATAKATSSLRRDSNDPGAGLPFVSRWVDYSRKHGVGYVLSDGTVGCIINATARAGQEPTPVTHVLVRNGQRWLKKVHQNKDFTGIDQVPLEIFEDRDLEGIKRKVYKGLGSVKEGPLLVEAERRRTLSVLWVKFGRYMCQSLDGSEETGDISPNQENFVRFYQRIGNVGVWAFADGCLQVHFPDHTKIVLSSSGQVISATVLTPEATSHLSQHGELLPQHVSNRDVLADSVQAMLFEGGRVRQRIVKANEISGKLAFIRDVVSQWITNDGLGRLDEDHQQQQGGGGAAKLSWQGLTVKENKTKVDRVTVGRYGGDDVRSTAAVETVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>M3B2G8</accession>
    <name>M3B2G8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_115245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF13947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762068.1">
        <property type="nucleotide sequence ID" value="XM_016901142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B2G8"/>
    <dbReference type="GeneID" id="27898279"/>
    <dbReference type="HOGENOM" id="CLU_3051918_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF13947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="54" mass="5561" checksum="1E51A3C59BBC743F" modified="2013-05-01" version="1">MAASQVASDIGAHSALTALIINRNGGQHTSNEAEASALADPLPVSLNDITGYYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M3B300</accession>
    <name>M3B300_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_62300</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762293.1">
        <property type="nucleotide sequence ID" value="XM_016909594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B300"/>
    <dbReference type="STRING" id="692275.M3B300"/>
    <dbReference type="GeneID" id="27906731"/>
    <dbReference type="eggNOG" id="ENOG502RYRH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_324430_0_0_1"/>
    <dbReference type="OMA" id="SWCWIGS"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF76">
        <property type="entry name" value="POLYAMINE TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="475"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="508"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="591"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="626"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="675"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="703"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="767"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="801"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="160"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="192"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="217"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF14172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="890" mass="99490" checksum="334F293A5B3242A0" modified="2013-05-01" version="1">MARGDTTTRKRLPWLEPVRSTDTRDENRSAPITYISPASLSNDLRYRPTGSTPEIREPTLRKHPRSYSDSSQRPSGVRSHAIARPRRELSQPEISSSEYNSTTPSDKDPLPPGFPKKDPRSYEELLSPATTTLKSPHPHLAQPKLERKPGTRNLQPRLAAQSSPFLLRNQQPTSPRKGTRTPKPNPNPYRYASNTPPALTHTTPTINALPAHLMAQSTSSSSDKQSISPTPPLLYRSANTPPAAPTRTLRSMDSLPAQSKQLHSFPDRLAAQESGYKRESGKPEAINISLKHPRRNHVSVKDNFHHHMHRPIAREWSLRRKRLTSAIACLNTIFVGFIAGIYAGEVPRIQYQLDDESHWVILGNVLLFAGLGLSTLLFWPLPLLHGRRPYVLIAFGAMLPLQIPQAMVVQHPHGSHMLYRTGLLLPRALTGFALGFANINFLPTLWDLWGASLMSDRPHQETVAYDDVRRQGTGVGAWLGMWTFCFSSSLSVGFFTGACVISKLNPSWGFWITIMLLTFFMLVNTIAPETRKSEHRRTISQFFEDETKHLKRRVARGEVKLHISNDGPKWWFEEVWAGVILTKRMVLQPGFFVLMAYLGWIQAQLTLVILLLGALLSRSYRWPSQWVGLAVLAIPTGAALAMPLTQASLLSRARVTPARTDSMTFQPRVTWSSHLLRRAIFTLLLPFAGLGFCLSSSGPPVHWSAVIILAGLVGFLADLGIAECVGLIMETFDTCDLQPGVNTRHRVQSMTIIAKKRRTNYSSFPRVCAGWFAAQSLGFFLAAGSTVAAGRVTDNYGAQTAISIVAAILLAVTVMLLIVLWRWKEVQVIPNFTMGTFRSNKETEMGQGDPEWKAVIIGHPSGKMRRMNLLEMGAWSRWTEIRKLNKLIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M3B435</accession>
    <name>M3B435_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7624 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_148222</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762658.1">
        <property type="nucleotide sequence ID" value="XM_016904783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B435"/>
    <dbReference type="STRING" id="692275.M3B435"/>
    <dbReference type="GeneID" id="27901920"/>
    <dbReference type="eggNOG" id="ENOG502SKIF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014596_0_0_1"/>
    <dbReference type="OMA" id="PRAHANQ"/>
    <dbReference type="OrthoDB" id="5230484at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056041">
        <property type="entry name" value="DUF7624"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24616">
        <property type="entry name" value="DUF7624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7624" evidence="2">
        <location>
            <begin position="620"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="557"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF14537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="745" mass="81194" checksum="815F727909627843" modified="2013-05-01" version="1">MALESPMMPISSPTAAGLASAFSPYSESPNSPARFNTFPSGGNYSNRSSGPTDSLAPPPPSPYPQQIEPSPVDSNGTEGTDIDEAAQEHEDDAGDEGDVLSPSPASSSDAFGLQSPDNEVGIPDLPPKIVTSLPRSLLSDSTDNDPQSVIHIPTGFKDFEGAHRQVASPERNPRLASPSTPEASVMSPSEQQQLSTVSPVNPETSQSAERLTPRAHANQELDEEAKRKCRRTSSLEGLLPGFDAYFQQHLTVHVDIPEGILDERSVADDDHDGGGSSRPTTAGLVGGERMEGPLEQAHDEITALRAALGECWTLCNTLANLSSSHRQRTFKFRGQTEVQQHAWQSCWRLCQQLYDNKDEDHTAQVIPTLELCRDFCQSLFDARARVDEATDSVLRVSFELNNHLYNINSNDIPNAFVERTLDFYITLCHRLMKMPTSLPRETDSLLRACWSLAEMLFNLRHSSREAKQADEELLGSAVQACWELCDLFREGWTQIRPDRGTPRPHQSTFGAPSQASLNSSSTTLGSAGRSTSSTVSNRKYHEAQPHLPPETPVTVFDETSTANSSPDSVIMPNILVLGPSSSHGSNRGAPHHDRWTSNASVLSDYSESAASGASRRSSSTASAGGEEVHLARLRALLLKAGINTGYVRTSGQQLPAYVKALPDSAFGILPWQMKVLGFYKKLVTNDKSLKNAHTMASRRIGAADVARSVRWLGDGEQWAWMRDLFRIVFGFGVDEAERRGGSFVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M3B454</accession>
    <name>M3B454_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_162646</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762683.1">
        <property type="nucleotide sequence ID" value="XM_016908014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B454"/>
    <dbReference type="GeneID" id="27905151"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_3_1"/>
    <dbReference type="OMA" id="WAHEEAS"/>
    <dbReference type="OrthoDB" id="2544694at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF44">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14610)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004031169" evidence="10">
        <location>
            <begin position="29"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="73"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="388"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="455"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="21"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="509"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF14562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="528" mass="57654" checksum="503BD737E392ECF3" modified="2013-05-01" version="1">MAIFQISAWKRMSSKNILALILIANTCAVAYEGYAQGVIGIANSAPDYLNLVGIAVNGSGQADRVITQGGITSIYYLGTIAGCVLAGWLSDKFGRVIALQFGALWCMLGIALEASAYNQPWIICARLIAGVGVAHMNCVAPTWVGEISEAAHRGKLFALVYLSNYIGIALAYWIGFGLSYVDQGQSAIRWRLPFALNALPPLMLFCLLPFLPESPRYLMSAGRPEESLEVLAHVRAEGDSSNSAVLEEYHEIEQSVQQAKTQASTSSFMALIWGSTSGKLHFPRRTQLALWLPLFTQVGTGIAATTIYTPTLIRQAGWGAEKALWLSALNNTVGVLGTVIAMYTIDPVGRRPTLLWGSLAQSACMWIIGAMSVLTASRPSQATQYGSATVAFIFVFTLIYSSTFLIINFNYPAEIFPTEVRSRGMAFGISGWAIGLGAGTLYNPVMFNSIGGYGFFVYGGLNLLWFVLIYLFLPETSRRSLEAVNRLFEIKSPFVRDMERHYRQYEDAGTAASEDNMSGKVEERAVHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M3B4L3</accession>
    <name>M3B4L3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_116004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762863.1">
        <property type="nucleotide sequence ID" value="XM_016901213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B4L3"/>
    <dbReference type="STRING" id="692275.M3B4L3"/>
    <dbReference type="GeneID" id="27898350"/>
    <dbReference type="eggNOG" id="ENOG502SCA2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_154736_0_0_1"/>
    <dbReference type="OMA" id="MSAEYKG"/>
    <dbReference type="OrthoDB" id="3359339at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF14742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="122" mass="12612" checksum="1FA693F85652DADC" modified="2013-05-01" version="1">MSAQQDPLEIAKQAERDLNTQEAKGNTKRAGDEVDASGIDESATTKFPGSTVKVGGQGAGNNREIPLEEGGSISKETGQPTKAKDFEGVGGPEDKAAIAADTRGGDDDITGNVRQGGETRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M3B4X1</accession>
    <name>M3B4X1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_155452</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762953.1">
        <property type="nucleotide sequence ID" value="XM_016907621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B4X1"/>
    <dbReference type="GeneID" id="27904758"/>
    <dbReference type="eggNOG" id="ENOG502RM62">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_528033_0_0_1"/>
    <dbReference type="OrthoDB" id="3638266at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="297"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="365"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="405"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="300"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="324"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="368"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="382"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF14832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="516" mass="59161" checksum="722118D831251AEE" modified="2013-05-01" version="1">MRWYDERGSSPCRSITAFSQIPLSPPPPPPPPPPPTLQNQLLLKNKQKSNKKMSSNTTEASYFLIPATSGLCIQPQDGSIQTSNLNGEQKQQWFIEHQTNSDGKIAFKNASSGEYLRATKGRVTVGEKHFWSIHLSTNTPNAFRIKFDTRQFLCNMYGKFTVDNLIHLVLDSPHDLQPTLWYICEFHSWRNAENWPVTRPKSPSSSSSSFSSERDATAKKDLAQREKNLKQKEKTIAQKEKNLAQKENLLQQKLLQAELREREALEFEQEAKIKLEEVDEKEQELEAEKLALKKNKNKARFSTSDSNSIPTHHDAENADDNDENPTTNNENNENDNQWLLRFSNLQQRLEIAYREIENLRRPVSSAGTKTTTTIATIANGDNDNDNDTDDNDDTDDNENSSSSIITSLQHELKLTKENAQKLKEENLLLRKTMNQSKNLDERNVSSLRRRGIRDNLDNLDVDEEASSVGNRWAPLNFRVERRMSTATGRREGEEEEEGIIGMIEIQKEFTFLERLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M3B634</accession>
    <name>M3B634_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">4-hydroxybenzoate polyprenyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_59916</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763398.1">
        <property type="nucleotide sequence ID" value="XM_016909510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B634"/>
    <dbReference type="STRING" id="692275.M3B634"/>
    <dbReference type="GeneID" id="27906647"/>
    <dbReference type="eggNOG" id="KOG1381">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034879_2_0_1"/>
    <dbReference type="OMA" id="QVARCRV"/>
    <dbReference type="OrthoDB" id="18170at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008412">
        <property type="term" value="F:4-hydroxybenzoate polyprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13959">
        <property type="entry name" value="PT_UbiA_COQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000008">
        <property type="entry name" value="4-hydroxybenzoate octaprenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1780:FF:000001">
        <property type="entry name" value="4-hydroxybenzoate octaprenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1780">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048:SF39">
        <property type="entry name" value="POLYPRENYL TRANSFERASE AUSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PRENYLTRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF15277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="354" mass="38626" checksum="B73EC809F487999F" modified="2013-05-01" version="1">MADSEPVPPREKPTSTSTTATTATPGVPAPQQYTPPSTLLFRLLPQSWIPYAELMRLDRPSGYYAFYWHYLIGLAFSACITTTPPPPAQLLGLAIYLAIWVMFFRGVTCTWNDNIDQDLDRQVARCANRPIARRAVGTVAGHAFTALLTVICGAMFLVFENRMVLVYAAIMTIVLFIYPFGKRITDFPQVILGFAFAIPVVMCPATLGADPLLITEGSGVTEAVRWGALCLYGANTLWTIIFDTVYAHQDIKDDIKAGVKSLAVRLGERTKLGLGVLSTIQVGLLVATGYLCDLSWSYFSNGCGGAALSLFGMLYLVDLERPESCAWWFGPGSKLVGASVVLGFLGHYFMLTGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M3BPL9</accession>
    <name>M3BPL9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_159631</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF08113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756234.1">
        <property type="nucleotide sequence ID" value="XM_016907859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BPL9"/>
    <dbReference type="STRING" id="692275.M3BPL9"/>
    <dbReference type="GeneID" id="27904996"/>
    <dbReference type="eggNOG" id="ENOG502RGA4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1220355_0_0_1"/>
    <dbReference type="OMA" id="RTSYTIT"/>
    <dbReference type="OrthoDB" id="4757738at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF08113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="227" mass="25062" checksum="EB4BCF1EA5461336" modified="2013-05-01" version="1">MGNVVSHVMRHHRGSTLARREIEDVLNRLSVLAEVKARNHHSRVTSHPIDAEILPIEKVVRKVHLAHCGVSSGNVKAVQDAIEEHFGYYMVGDVVEGLSAVLTETIDHLMNTLSSKNSSEFTSYAITIGNTGSIGRIDIYMFYYKFASPHVARMLSNCLITSLVVSMVEPSKLRLDDVRALAKAPYSSPLPGESEREADERLERIENLLVQVTQTALGKALQRSASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M3BWS8</accession>
    <name>M3BWS8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_133233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760617.1">
        <property type="nucleotide sequence ID" value="XM_016902551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BWS8"/>
    <dbReference type="GeneID" id="27899688"/>
    <dbReference type="HOGENOM" id="CLU_567624_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="234"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="452"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF12496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="481" mass="53827" checksum="D975BAE4E6DBD933" modified="2013-05-01" version="1">MGIKADMIAGEAAMEELESIINGENFIFEDTVNEDLQSSVESDFSSEEENTTIEELDLREERSFSDEDLIDEDIELFRKRQNNPLFASFHTPYIDSVMNEVEDIATLVNIEDLGADTSPIDEAYPTPYDWVEYENDVAEVTAENNDIVEVFGEQFATIAATGGNLLSAWLLISAYFHVCKVAGTWVPGKLTKERSASLVSEYGHLILRAATKSVEEISRFTASLGSNNMPPAPQQHQQQQKQQQHLPPRWQQLFHEFSLQGFEHEDLMMQFRKLLGETSNPKVAETIFEQTFRNLSAETRLLNFAPALQQYFFFPHSSCSSPSNDETTSDDDDALRALITKFNPEANLMFLNNMKKNKRGNTRISEKEKGRLSHPPPPPSSPYPVSKRSLQSQGQSQEKKKKMQKTKTEKKKKKTVKKTGSSNDGSKKKVGGGVSAGRVMKKGKPVTAAAASGTKMTNSATTTSDTAATIGARRYNLRRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M3BZM1</accession>
    <name>M3BZM1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_64456</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761622.1">
        <property type="nucleotide sequence ID" value="XM_016909680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BZM1"/>
    <dbReference type="STRING" id="692275.M3BZM1"/>
    <dbReference type="GeneID" id="27906817"/>
    <dbReference type="eggNOG" id="ENOG502QQEF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_929261_0_0_1"/>
    <dbReference type="OMA" id="IPICKAT"/>
    <dbReference type="OrthoDB" id="160645at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14295">
        <property type="entry name" value="PAN_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004031507" description="Apple domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="48"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="189"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF13501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="300" mass="28788" checksum="08BEFE2F79662731" modified="2013-05-01" version="1" fragment="single">MVSSVFAGLVAVAGIASALPQSTPTGSRSCEVIGSGNQDGQYTVTCGADRPGGDLSNGQAGSFEGCMPMCDQLAGCIGFAWVEGYGGGTCYFKSSLVDQINASNVDMAVKPDSSASSIASTSSIVSTSSVATSSSVAPTSSIASSTSASSTSVVASSTSVTPTSTAGSSCQQLASSGTTTDGYTIECGTDRSGGDLSAAPASSFSGCIPICKATAGCVGFSYVGGSNAGTCYLKSSITTASSNSNVDTAVMLSGGSSSSSSVASSTSSSSTSAVALSTSSSTSTIVPSTSSSSTSTAALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>M3BZX4</accession>
    <name>M3BZX4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_148853</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761737.1">
        <property type="nucleotide sequence ID" value="XM_016905186.1"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="3647089at2759"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF13616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="101" mass="12139" checksum="86A3AC476EBC719E" modified="2013-05-01" version="1">MVTTTTTTTIPVFVNERRTWVVTNIKHYVRRQDIIDYMEQEYPTVYDARRKKNIQNYNVDTRPNGTHRVWAARLLRDDEVKLLEDKNNTGTKYEDDDEDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M3C1L0</accession>
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        <recommendedName>
            <fullName evidence="3">Mitochondrial export protein Som1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_41638</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016908835.1"/>
    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502SG5C">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142986_2_0_1"/>
    <dbReference type="OMA" id="TTSWEPI"/>
    <dbReference type="OrthoDB" id="3983163at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024645">
        <property type="entry name" value="Mitochondr_Som1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11093">
        <property type="entry name" value="Mitochondr_Som1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF14196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="99" mass="10991" checksum="1B10B4191E651A8C" modified="2013-05-01" version="1">MAPILEAFHASELQSRINTLPTGKAHKSPVKDLKKECTLKELLQYNCDLDGPKDDPKSKVVCKPVLRLFRQCANGLTVETTSWEDRFDGSTADGGNLMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>M3C1M4</accession>
    <name>M3C1M4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_115497</name>
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    <organism evidence="1 2">
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        <name type="common">Poplar stem canker fungus</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762332.1">
        <property type="nucleotide sequence ID" value="XM_016901166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C1M4"/>
    <dbReference type="GeneID" id="27898303"/>
    <dbReference type="HOGENOM" id="CLU_1797675_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF14211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="144" mass="15454" checksum="DFF1F63326C1DDB0" modified="2013-05-01" version="1">MPVQGPLLFLLGRPKSCQSNLVHGCRGRHGVIVSVLAIDPDEYLVCASPYYEDDTFVPDDAVTFLVCGALNGTAGNPDGKITQTNTLDGWLHCTGLNDFYSKCSDEYLELCIKYGAQGIQCCPPIGDDPDNAPSCNQANGNPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M3C3S3</accession>
    <name>M3C3S3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_146927</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF14896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016903965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C3S3"/>
    <dbReference type="GeneID" id="27901102"/>
    <dbReference type="eggNOG" id="ENOG502SR76">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_143689_1_1_1"/>
    <dbReference type="OMA" id="TSWKQWR"/>
    <dbReference type="OrthoDB" id="2787676at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF14896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="115" mass="12601" checksum="E96DF6A728E69AC9" modified="2013-05-01" version="1">MKKALTPGINGASEGNMWKKFTNVSVGRGKTVFPRSPAEQERFGVRWDFDGEVVKPDGVYNKFRMQPNAGKIPSSIKAWRDANGGTHAVMADAYIKKEGSQDDVQKGLEDAAKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M3C5K3</accession>
    <name>M3C5K3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_147401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_016904278.1"/>
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    <dbReference type="HOGENOM" id="CLU_1928917_0_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF15546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="131" mass="13545" checksum="EB1E7E6DC8D5082E" modified="2013-05-01" version="1">MRCGVTEGWTTTAATGDSFRDGGGVGVGGAGGDDGDGGDGDGGVGIGDGGDRRERGRGGEVALGQPDNQSVRVRQSPRDLDNVLRRSSISQYLLGERREGGREGGSGREERCAKTDRNSLMCKKQGLPSEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M3C6S4</accession>
    <name>M3C6S4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_147659</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764042.1">
        <property type="nucleotide sequence ID" value="XM_016904442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C6S4"/>
    <dbReference type="STRING" id="692275.M3C6S4"/>
    <dbReference type="GeneID" id="27901579"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043291_2_0_1"/>
    <dbReference type="OMA" id="YGANAVR"/>
    <dbReference type="OrthoDB" id="439993at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12291">
        <property type="entry name" value="RRM1_La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002344">
        <property type="entry name" value="Lupus_La"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF140">
        <property type="entry name" value="ACHILLES, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00302">
        <property type="entry name" value="LUPUSLA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="7">
        <location>
            <begin position="128"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="235"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="320"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="34"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="102"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="367"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="393"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="415"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="436"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF15921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="451" mass="50780" checksum="9FDBEDAF56762FE0" modified="2013-05-01" version="1">MAEAAAEPQAAAPEQKVQDSKPTEATNGGAEKTNGSDDKSGEKTEMTDNDQRHADRRGSHDDGGKGDRRDNRDNRDGGDRRDRRDGGRGDRRGGGRGRARGRGNGGFRGRGGGGYQNRDRNVRTRFERDEESNDAGEIRRQVEFYFSDSNLPIDKYLLEHTGGSENKPFPLKSLHTFKRMRHFKPFSAVVDAVKGSAFLEVNDQDEVFRKEPLDSKFTLDTVANNELLTSDSIRRSIYAKGFGEEHDKSAFEIEEFFQPYGVRSVRLRRQQDGTFKGSVFVEFEDEDAAKQFIEMEDKPKFNDKDLIIKSKKEYIDEKSQGILDGTVKPKSPTRTGFGNSNRGGRNGGDFKRKRNHDDDADADGEDRDNWRDRRDKFQKDGRGGRGRGRGRGRGGDRRGGRDRDASRSASRSRSPRREEEKKEQTEGATLEQAAPDEIKAEAKEEAVKTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M3C6Z3</accession>
    <name>M3C6Z3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphatidylserine decarboxylase</fullName>
            <ecNumber evidence="3">4.1.1.65</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_147710</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Phospholipid metabolism; phosphatidylethanolamine biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="3"/>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF16011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764132.1">
        <property type="nucleotide sequence ID" value="XM_016904475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C6Z3"/>
    <dbReference type="STRING" id="692275.M3C6Z3"/>
    <dbReference type="GeneID" id="27901612"/>
    <dbReference type="eggNOG" id="KOG2419">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029061_2_1_1"/>
    <dbReference type="OMA" id="SIKWTGG"/>
    <dbReference type="OrthoDB" id="5973539at2759"/>
    <dbReference type="UniPathway" id="UPA00558"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033177">
        <property type="entry name" value="PSD-B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00163">
        <property type="entry name" value="PS_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF17">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF16011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="389" mass="43380" checksum="29141E608A6435CB" modified="2013-05-01" version="1">MASPSKGPKFLPANLPTDHLDAAEKALSQVTDNAAGKPHEDPKKTLHAPSAQEEQHSWMRSIFPYSSLQEMEAAFHMGNYVLDRKTGEKSFEEMSIYVRLGMHLLYYGSEQEKALHWRRAKALLKEQSIKMGKQYDAPESVEHIRPFIESFNLQETLDELKKPDIKQYATFNEFFARELRDDARPIDEPDNDKVISSPADCRLTVFPTISLAKKYWIKGIGFSVQRLLNSDITRARMFEAGCINIARLAPQDYHRWHSPINGTVDSIMELPGTYYTVNPQAVNEPGSLDVFCENKRSVMIVTRKETGAKVAIVAVGAMLVGSIRYNHGIAAGSEIARGQCLGAFLYGGSTVIVLYPKGEVVLDEDLVKNSVEKGCETLVSVGWRVGAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M3C8K6</accession>
    <name>M3C8K6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Complex I intermediate-associated protein 30, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_14133</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CIA30 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF08220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756341.1">
        <property type="nucleotide sequence ID" value="XM_016902961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C8K6"/>
    <dbReference type="STRING" id="692275.M3C8K6"/>
    <dbReference type="GeneID" id="27900098"/>
    <dbReference type="eggNOG" id="KOG2435">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059028_1_2_1"/>
    <dbReference type="OMA" id="RIHKIWA"/>
    <dbReference type="OrthoDB" id="42561at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010257">
        <property type="term" value="P:NADH dehydrogenase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013857">
        <property type="entry name" value="NADH-UbQ_OxRdtase-assoc_prot30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039131">
        <property type="entry name" value="NDUFAF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194">
        <property type="entry name" value="COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194:SF18">
        <property type="entry name" value="COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08547">
        <property type="entry name" value="CIA30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase intermediate-associated protein 30" evidence="5">
        <location>
            <begin position="35"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF08220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="249" mass="28010" checksum="0E52F1005DDBD62C" modified="2013-05-01" version="1" fragment="single">PGFFRRSMDEFKRQAKFAVKMEGLHIPIKPYPLIKFDEKLSPERCKIMCDSDVGGFSRASLTYVDGAEHMERTIGEGESDSKKGGVIISEPGKEPSHAVFKGTISTDLPQNRPQIQRSGYAGFRTRDRGLSLFGKLLWDLSPYSYLALRIKSDGRKYFVNFQTESIVPTDLHQHLLPSSTPGEWETVTIPFSAFVRTNYGQVVEPQREMMSTKVRSVGISLIDRVPGQFELAVADIYATNRAPERKSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M3CCT2</accession>
    <name>M3CCT2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_151217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758343.1">
        <property type="nucleotide sequence ID" value="XM_016906676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CCT2"/>
    <dbReference type="STRING" id="692275.M3CCT2"/>
    <dbReference type="GeneID" id="27903813"/>
    <dbReference type="eggNOG" id="ENOG502SFH4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042426_1_0_1"/>
    <dbReference type="OMA" id="TPMSATY"/>
    <dbReference type="OrthoDB" id="5405654at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42053">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42053:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="290"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF10222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="299" mass="31407" checksum="4F1D73C42B7C46C5" modified="2013-05-01" version="1">MATASSSATMAAAGFDKRPARLDTASLPTPGSSTFPSELPSPMVSTPAFTKRDEALRTPITPPSAYLDFLKNYTPAIQSPASSTSAKCGFSDKTFDRSLDKSGSEIPGPKSSVSPPTSQPTLSRNTSCDSSTSELSAVASSSAASVCSKRPESPRVIIPPSPFVKPAPRSAGTPRRLHIPTSCFSPSLASAQSVPSPYSSTPLSAAPWNATFSPREPPADIGGPSGKVHVRHVVTRTVTYCRTPLDPAPKGKRRKIEADDDVSSSKAWSEDPNPEIKQERISKIDEESSSEASENASDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M3CF49</accession>
    <name>M3CF49_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DUF803-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_163560</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760524.1">
        <property type="nucleotide sequence ID" value="XM_016908069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CF49"/>
    <dbReference type="GeneID" id="27905206"/>
    <dbReference type="eggNOG" id="KOG2922">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012349_5_1_1"/>
    <dbReference type="OMA" id="KNAWWWL"/>
    <dbReference type="OrthoDB" id="6428174at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF92">
        <property type="entry name" value="SPICHTHYIN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="426"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="559"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="618"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="647"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="689"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF12403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="720" mass="77986" checksum="4791762747AE803A" modified="2013-05-01" version="1">MDVAGNVLFHAADLVLRQATETTDTPTSTVSATPSSTSSAASGTTARPGYYKIVGIVLAVTSGLFIGTSFVIKKKGLLSANVKYSEEAGEGYGYLKNAWWWLGMTLMIVGEICNFVAYAFVDAILVTPLGAISVVVCAILSWWILKERLSFVGWVACFLCIVGSVTITLNAPEQSAVSNIQEMQHYVIAPGFLSFAGVIIVGCIVVAVWVAPKYAKKSMMVYLTICSLIGGLSVVATQGLGATIIAAIGGEQQFNKWFTYVLLVFVICTLLTEIIYLNKALNIFNAALVTPTYYVYFTSSTIITSAVLFRGFHGTTNQIIDVVMGFLTICSGVVLLQLAKSSKEIPDSKVLSGDLDQIRAAAEVEEPEYEPRADTIRGGAGIIRALSRTRTKKEAEEVKRINEERMQPIGENEVAEWDGLRRRMTVSTQGGSVRRSKTPHPPLGMSQFPPDDISEPDSEVHPGFFGRIGRNFTQRRQQRGHSPVPLDSVSVGKHEYSMPGEPQRVDGHDDDDEDDTAYKGATSSSQHIHFSDQASERDRAVSQSSSLAPPRPPPHGNGSRPNTGGASRQFSFQNVFSRNRSDAGSVDAGIRPLSRGALSFQSRGSASREYPRAATTTEEERLGLVHGDSHKNLPVYTEEPEEQDASSIRRSDSDEWHIPSGRSSSPDALGASPSGNVGSSGGRRRRDDYDDDNDDDDLYDAHIPRDNSSGGTGRSGRAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M3CFH0</accession>
    <name>M3CFH0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Succinyl-CoA:3-ketoacid-coenzyme A transferase</fullName>
            <ecNumber evidence="3">2.8.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_149196</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate</text>
            <dbReference type="Rhea" id="RHEA:24564"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35973"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.8.3.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Ketone metabolism; succinyl-CoA degradation; acetoacetyl-CoA from succinyl-CoA: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 3-oxoacid CoA-transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.5" evidence="3"/>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760684.1">
        <property type="nucleotide sequence ID" value="XM_016905402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CFH0"/>
    <dbReference type="STRING" id="692275.M3CFH0"/>
    <dbReference type="GeneID" id="27902539"/>
    <dbReference type="eggNOG" id="KOG3822">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019942_1_2_1"/>
    <dbReference type="OMA" id="VKTMGQI"/>
    <dbReference type="OrthoDB" id="1933379at2759"/>
    <dbReference type="UniPathway" id="UPA00929">
        <property type="reaction ID" value="UER00894"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008260">
        <property type="term" value="F:succinyl-CoA:3-oxo-acid CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046952">
        <property type="term" value="P:ketone body catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1080.10:FF:000001">
        <property type="entry name" value="Succinyl-coa:3-ketoacid-coenzyme a transferase subunit b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.10">
        <property type="entry name" value="Glutaconate Coenzyme A-transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012792">
        <property type="entry name" value="3-oxoacid_CoA-transf_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012791">
        <property type="entry name" value="3-oxoacid_CoA-transf_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014388">
        <property type="entry name" value="3-oxoacid_CoA-transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004164">
        <property type="entry name" value="CoA_transf_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02429">
        <property type="entry name" value="pcaI_scoA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02428">
        <property type="entry name" value="pcaJ_scoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707">
        <property type="entry name" value="KETOACID-COENZYME A TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707:SF23">
        <property type="entry name" value="SUCCINYL-COA:3-KETOACID-COENZYME A TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000858">
        <property type="entry name" value="SCOT-t"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01274">
        <property type="entry name" value="COA_TRANSF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 5" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="5-glutamyl coenzyme A thioester intermediate" evidence="4">
        <location>
            <position position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000858-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF12563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="519" mass="55321" checksum="4A7463899B76874A" modified="2013-05-01" version="1">MVSSITLGVRTAINLSRTTPSSRLLARTFASSSRNHAINKVVSSPEEALKDMKPNSTLLCGGFGLCGVPDTLINSVEKMPHITGLTAVSNNAGVPGSGLGKLLASKQVKKMIASYVGENKVFEKMYLTGEIELELTPQGTLAERCSAGGRGVPAFYTPAAVGTVVASGELPLKHNAEGDVVQFSSPKDIKVFDGKPYVLEEAIKGDVAFIKAWKADRLGNVMFRFAAANFNGAMARNAKETIVEAEHIVEPGEIDPAAVHVPGIYVNKVIQSTTSKEIEKVVNAKSPEELKAGALGSGETANKRERIVRRAAKEFQNGQYANLGIGMPMLAPSFVDDSIEVQLQSENGILGLGPYPQKGTEDPDLINAGKETVTLRPGAAVFGSDESFGMIRAGRINLTILGAMQVSAKGDLANWMLPGKIKGFGGAMDLVSNPEKTKVVVTMEHTDKKGRPKILNTCTFPLTGPKCVSLIITELAVFEVDFTHGLTLIEHAEGVTVEEIQSKTEAPFKVSESLKVMQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M3CHV9</accession>
    <name>M3CHV9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_116414</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761489.1">
        <property type="nucleotide sequence ID" value="XM_016901252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CHV9"/>
    <dbReference type="GeneID" id="27898389"/>
    <dbReference type="HOGENOM" id="CLU_940632_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF13368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="296" mass="32323" checksum="FE8D274FC5E931D6" modified="2013-05-01" version="1">MPQTLQEKIVSRMEQENFARRQNRRAKFGAEMTALQVYFQTEQDKLHVQYVAQAEKVDQDYHADMITIWTAQQKCVEEIKEEFSRDPDAAHAKYGPKPAEPPAANTRTQYLRVHGAVHPTPALPTNTVEGNRVQPHVPFGGVPSQDARGNKRSASVWVTPSPRPILPNPPGRLPLSAPQTRSPAGQPQQEPVGSGGPVDIPLAATSGGALLEQTPTRPGGSKRRKMTSEGELCEDGEDGEDGEDGEDGEDGEDGEDGEDREHREDLDKVSSNGSRDVRPRLGPEHLVDLTSEGSCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M3CKD8</accession>
    <name>M3CKD8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_115528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762369.1">
        <property type="nucleotide sequence ID" value="XM_016901173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CKD8"/>
    <dbReference type="STRING" id="692275.M3CKD8"/>
    <dbReference type="GeneID" id="27898310"/>
    <dbReference type="eggNOG" id="KOG0575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_461632_0_0_1"/>
    <dbReference type="OrthoDB" id="310217at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053083">
        <property type="entry name" value="TF_kinase-domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44305">
        <property type="entry name" value="SI:DKEY-192D15.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="243"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF14248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="591" mass="66221" checksum="16840112CD97F164" modified="2013-05-01" version="1">MSGSSFEELFGSFTIVDPATPKVPRATSGAGVATAAATDDPRVLETHFIAFGTDQESFDSEEQQETQFHALKIDFRKFELAQQKEIVTQILKINSRTEILVSQQKSIDEALKNFKDPRPIWRDVARSCTSILTVLTALQNRYTSSSPTSPSVFAQVLNNRIRHIESVQQTANVAKQRNPTNAAGGSDMFDELLFAMAKEQNSQRVWKVDVGRVQRAEIARRNRAKKAGIKPIRGKFSALPDMWHALDVMGGGMGKITVYGKEDGRGRIVDRVVVKDTTSIGFDEEENWYGKGTEKVPIEFWVHKKLADTKCPHFLGLASDEVQVDDAIATFRMFLEYASQGDLNELLGRHLEAGELLPEAFILYVFRALIETCLIMQRGKAGRVLDKSWEQIVHRDLKLDNVFLGENSITSFPAYPQVKLADFGIAIVTAPDDPANPSLYNRQTGTPGYLPPEQCAFSHPETGEAIDDFKLLSPCNVWGIGAIILCLLRNKKILSTEQPTYLPGGTWFYECDETARKTYSKELCSTVDRCLAYDPVHRPTLEQLEKWILDAIVADPWLAKQADIRSIGKGPMPYENRILEKTHKHYVGMAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M3CL97</accession>
    <name>M3CL97_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">UPF0075-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_82940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762684.1">
        <property type="nucleotide sequence ID" value="XM_016910324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CL97"/>
    <dbReference type="STRING" id="692275.M3CL97"/>
    <dbReference type="GeneID" id="27907461"/>
    <dbReference type="eggNOG" id="ENOG502QUN9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038782_1_0_1"/>
    <dbReference type="OMA" id="TGPGNMV"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006040">
        <property type="term" value="P:amino sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd24051">
        <property type="entry name" value="ASKHA_NBD_LGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01270">
        <property type="entry name" value="AnhMurNAc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005338">
        <property type="entry name" value="Anhydro_N_Ac-Mur_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30605">
        <property type="entry name" value="ANHYDRO-N-ACETYLMURAMIC ACID KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30605:SF0">
        <property type="entry name" value="ANHYDRO-N-ACETYLMURAMIC ACID KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03702">
        <property type="entry name" value="AnmK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF14563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="428" mass="47245" checksum="87E8670B1EC503C9" modified="2013-05-01" version="1">MTVLGLNSGTSMDGIDCALCRFRQSSPEAPMQFELLQYDEIPLEQKIKKRVMNMILKNTTTPEELSEVNVLLGETFARAVQEFTSKHDIPTSTIDAIGSHGQTIWLLSMPEQGQTQSALTMAEGTFIASRTGITTVTDFRVSDQAAGRQGAPLIGFFDSLVLHHPRKLRACQNIGGIANVCFIPPDHDGKLNQEYFDFDTGPGNVFIDAVVRHFTNGEREYDKDGAMGRAGTVDQEMVDEFLTQHPYFSKAPPKTTGREVFRDTIAHDLIDRGLKKGLSQNDIVATVTRITAQAIVDHYHRYMPQQYGPLAEIFMCGGGAKNPNIVDYMSRAFPETRIVMLDEAGVPADAKEAITFAWQGMEAIVGRSIPVPDQVESRQPYVLGKISPGKNYRAVMRQGVQFGAGQDVLEPVSELVNIVNGKVFNNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M3CNV6</accession>
    <name>M3CNV6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_105709</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763574.1">
        <property type="nucleotide sequence ID" value="XM_016900585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CNV6"/>
    <dbReference type="STRING" id="692275.M3CNV6"/>
    <dbReference type="GeneID" id="27897722"/>
    <dbReference type="eggNOG" id="ENOG502S7KP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083683_3_2_1"/>
    <dbReference type="OMA" id="HRPINPE"/>
    <dbReference type="OrthoDB" id="2351920at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008401">
        <property type="entry name" value="Apc13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28526">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28526:SF1">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05839">
        <property type="entry name" value="Apc13p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="80"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF15453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="116" mass="12531" checksum="C851D302419D067D" modified="2013-05-01" version="1">MSRDSSFSHLHMHAAHHADLLEDFTRIKLPAEEILVAPQHQPLNPDNEEDLVPDQHAAFGIQRAQQKTREPAWKDLSLHALMTDPPPSSSSSGTKRGGGLAAATGGAVRSGNLVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M3CQB2</accession>
    <name>M3CQB2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_147631</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat cdt2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763994.1">
        <property type="nucleotide sequence ID" value="XM_016904427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CQB2"/>
    <dbReference type="STRING" id="692275.M3CQB2"/>
    <dbReference type="GeneID" id="27901564"/>
    <dbReference type="eggNOG" id="KOG0321">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018451_0_0_1"/>
    <dbReference type="OMA" id="RTAHNNR"/>
    <dbReference type="OrthoDB" id="2096344at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051865">
        <property type="entry name" value="WD-repeat_CDT2_adapter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22852:SF0">
        <property type="entry name" value="DENTICLELESS PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22852">
        <property type="entry name" value="LETHAL 2 DENTICLELESS PROTEIN RETINOIC ACID-REGULATED NUCLEAR MATRIX-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="272"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="314"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="563"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="565"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF15873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="681" mass="75106" checksum="A5D431F6813F20A0" modified="2013-05-01" version="1">MADLPPPSSQESQYFEHHKIAFQKENFQSSPPRPQSRSSNAYSTQKPKGLPTITPRRFRKFFQPQKSVSTRGSRTSKAGRQLRDITRNGVNRRAAGDVRVVDDFVPGPEYSSSCARPLKRRKFSADIHSSPLQSSPLRHGQVAEPIDIFDGELSEAETLPDLLRKLEPRPKQIQRLRRPGPSRRIMERSFGGFDALSQGFRGVDHGVDWRAETADFVTTPQDSRVFGSGPALPFCTTACNTNPLVAVGDEEGSVHIMDSSLAAEFSQLHLKIKVHSNAVMDIAFSSDDYILATASGDQTARVVDMQSQRTICILSGHKSSVKQVRFQPTDDNMITTSSRDGSIQLWDLRCGGKSAVQNFRTSLKSRSGGVSPETRYGKTLEVAYGHKSDERSYNSGQRDELSITSFHHLPNGREHMIITSSEVDASVKLWDVRNAGMSARRGAPVPVSSTPVPAAHGSKRNFGINAMALSGDGSRLYTVCRDWTVYAYSLNQIVLGNAPEMSSGSSRRRMLKEPMPGLGPLYGFKHPQLRLATFYIKAALRPAAGGKGEMLAVGSSNNCPVVFPTDERHLPQRERPSQDDQEDEEDYGLPAPARASQRASGSDVPIYEQGTALVGAHSKEVTSLAWTTEGNLISVGDDYSARCWREDAQKARALRTNGDFGGERWQMGWADVDAEWDEEEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M3CQT0</accession>
    <name>M3CQT0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_131593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF16033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764154.1">
        <property type="nucleotide sequence ID" value="XM_016902434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CQT0"/>
    <dbReference type="GeneID" id="27899571"/>
    <dbReference type="HOGENOM" id="CLU_676475_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="244"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="289"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF16033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="407" mass="43750" checksum="73D4E16CD2960292" modified="2013-05-01" version="1">MGSKRSSDGETSEERESQRLRLSPDWEETSSLFGGDEDLDPLFGAGEVEEGESDPLFDEPEAAQTLQAPQASSSGLALPTGAPRAATLGLALPTGAPRAVASGLVLPTGAPRVMTSGLVLPTGQPRAVASGLVLPTGAPRAVTSGLVLPAAAPEAASSRLVVPVMTPAASEGGRASRARSEGPVSVGDEATRATKSPGPAEQPAAGRRRSRKGKEPMVATPAMIAAMRQQLPGQVDAAARFAATAARVRASAVPPDHQQQQQQVQQEEQQQQQQQVQQQQEEEEEDQQQRQQPEQDQQQPQQPRQEQQQQQQQQQPQQPQAAPLTKAERRARLRAQHEAAKAARDAATLNFGKLSEEEQARRVAEQRRAAGEPEEHPDPFTSARDLRRQRATAKQREYRAAQASRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M3CVI4</accession>
    <name>M3CVI4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphoadenylyl-sulfate reductase (thioredoxin)</fullName>
            <ecNumber evidence="3">1.8.4.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">3'-phosphoadenylylsulfate reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">PAPS reductase, thioredoxin dependent</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">PAdoPS reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SEPMUDRAFT_152434</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[thioredoxin]-disulfide + sulfite + adenosine 3',5'-bisphosphate + 2 H(+) = [thioredoxin]-dithiol + 3'-phosphoadenylyl sulfate</text>
            <dbReference type="Rhea" id="RHEA:11724"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="EC" id="1.8.4.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PAPS reductase family. CysH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.8" evidence="3"/>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF08167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756288.1">
        <property type="nucleotide sequence ID" value="XM_016907443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CVI4"/>
    <dbReference type="STRING" id="692275.M3CVI4"/>
    <dbReference type="GeneID" id="27904580"/>
    <dbReference type="eggNOG" id="KOG0189">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044089_0_1_1"/>
    <dbReference type="OMA" id="PIARWTQ"/>
    <dbReference type="OrthoDB" id="7869097at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004604">
        <property type="term" value="F:phosphoadenylyl-sulfate reductase (thioredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019379">
        <property type="term" value="P:sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd23945">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000151">
        <property type="entry name" value="Phosphoadenosine phosphosulfate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00063">
        <property type="entry name" value="CysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004511">
        <property type="entry name" value="PAPS/APS_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011800">
        <property type="entry name" value="PAPS_reductase_CysH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00434">
        <property type="entry name" value="cysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02057">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002537">
        <property type="entry name" value="PRK02090.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46509">
        <property type="entry name" value="PHOSPHOADENOSINE PHOSPHOSULFATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46509:SF1">
        <property type="entry name" value="PHOSPHOADENOSINE PHOSPHOSULFATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoadenosine phosphosulphate reductase" evidence="14">
        <location>
            <begin position="62"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="239"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00078053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00082553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMF08167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="302" mass="34280" checksum="B770C360AB2CFE5B" modified="2013-05-01" version="1">MGFRERSSSSDQESGYASGSSSASLPEVYFTRPHLKYINATLAKLEPQKVLEWCVITLPHLYQTSAFGLTGLAIMDMLSKLDSKPDVECIFLDTLYHFQETLDLVQRVQTRYPDMTIHSYKPEGCNTTADFEAKFGERLWETDDEKYDFVAKVEPAQRAYRELDVAAVITGRRRTQGGKRGDLDIIEVDEAGMLKINPLANWSFADVKSYIEANHVPTNVLLEQGYRSVGDWHSTQPVKEGEDERAGRWKGQKKTECGIHNKRSRYAIFLEEQQAKQKREVAEAIQDGLGMKCSPLDVIRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M3CW75</accession>
    <name>M3CW75_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DAO-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_53992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756513.1">
        <property type="nucleotide sequence ID" value="XM_016909283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CW75"/>
    <dbReference type="STRING" id="692275.M3CW75"/>
    <dbReference type="GeneID" id="27906420"/>
    <dbReference type="eggNOG" id="ENOG502SK7Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022730_2_1_1"/>
    <dbReference type="OMA" id="RTLEKMH"/>
    <dbReference type="OrthoDB" id="429143at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF213">
        <property type="entry name" value="DEPENDENT OXIDOREDUCTASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="53"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF08392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="528" mass="58507" checksum="E11888DCEB6EE7EF" modified="2013-05-01" version="1">MSNIPPKVISHLIQEANQDPQLPRENPTEAFWQLPPSPLSTHQSPALPAQTTYAIIGSGVTGCSVAKTLLENLPSDSQATVTVLEARSLSSGATGRNGGHLVSPLPEEFTSFEKYLGKEETTKVARFANRTLESMYALAEEDEELSRVSEARRVKSVCAIYDQELFEETKKSVLRYEECLPEQKGDNEFFGPDEARDKWNMKDAVGVITNSAGAFWPYRLITGLFSRLLSRYPTRFFLETQTPVTSISPTASSNPEYPYTLHTPRGPLLATNIIHCTNGYTSHLLPSLRGKIWPLRGTMSVQTPAPSFPKDINNPNKTTSFLKSWSTLTKSHYDASTGQFEYGLYYVTQNAHSGDLFVGGERQLLENELLTSDDTQTSAISEATLRSVLGRIYEKGGGGGEQEQEQEQVVVKSLWSGIMGFTPDHVPWVGKLPESVASHHGHYLREYIAAGFNGYGMPLCWGCGEAVAKMLLGQQDEISEWFPGSFMITEQRLASPWTSTEAGIYNMLVQEPPLSVRERLASCREELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>M3CWN9</accession>
    <name>M3CWN9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_159612</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF08086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756207.1">
        <property type="nucleotide sequence ID" value="XM_016907858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CWN9"/>
    <dbReference type="GeneID" id="27904995"/>
    <dbReference type="HOGENOM" id="CLU_1587514_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF08086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="168" mass="18233" checksum="974CDD42AEA8174A" modified="2013-05-01" version="1">MQSCREVRKQICQVAPRDLDRFLSLLVEATSLAFHNQGERSVGSAVYVESSHTPSGTKKFEVLDDKDAAAICPSVGTGQDRTAQCCRNNSCAVSTIRGEACCFDRCHRHLVSSGAQPIEEMIVAVAMNCLCDRVGSLHASTSIDKRIGTTQETASRLRPALRTYIVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M3CWR8</accession>
    <name>M3CWR8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_152399</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF08121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756242.1">
        <property type="nucleotide sequence ID" value="XM_016907423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CWR8"/>
    <dbReference type="STRING" id="692275.M3CWR8"/>
    <dbReference type="GeneID" id="27904560"/>
    <dbReference type="eggNOG" id="ENOG502RW98">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1125125_0_0_1"/>
    <dbReference type="OrthoDB" id="62952at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF08121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="247" mass="28169" checksum="F1F067550E16596E" modified="2013-05-01" version="1">MDLPAPVKIRVYRLVVVDSRLCVWPASVNDREQPDISMVCREIRLAVLPIYYGENTFAVDITAPAQGVRMLAQNYEQASKRQPVTGLIAVERWAERMSAKHNEGGKCFTAVKKWCFSYRDPLAGFESTKAAPSNPIPDESFVTSVRFPMTRRKKTDKKIKIEVHRRAACVMPGWRDYGECAAMAAPDALYAAVAIWRQTGVQKPEALFQFVLNMRELVDQLSFQRCENVRRNHRGDRMKRCPKSEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M3CX84</accession>
    <name>M3CX84_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_111645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756402.1">
        <property type="nucleotide sequence ID" value="XM_016900927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CX84"/>
    <dbReference type="GeneID" id="27898064"/>
    <dbReference type="eggNOG" id="ENOG502RI5G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_787938_0_0_1"/>
    <dbReference type="OrthoDB" id="3644764at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF08281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="40427" checksum="1BABD25870B89D80" modified="2013-05-01" version="1">MSTSANSQTAARTIDITPSSFASLPPTQNTSLQQPTAHQRFLNNPRHLKRLFTHTTLKSLLACQRVCKLWNQIITSSHACKEKLFLTSSPPRSLDCIHYYCQQQQQQPRLNPLLTQVNESISHLHPVYDSFLSESVNNNTLILTWKGSFYTPQIFFPRASNPSLGNVSVPADADADRQLGEEKEEIGIEFQLRRLSRFEVCFLSLRHYHHCQNYENHQHEVEKGGSKKKTSANNKKKDLDDLIFPGPEASLWNMYLCQPPPSSVNVTVWKAEEEYLEGDAEAGWSRQSGSTSGYVTERFMIHKAWTMREIFERMDEARSRARSKDEKVEDISSLMKRKRKGSVVKDLLLLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M3CXF7</accession>
    <name>M3CXF7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sugar_tr-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_54406</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756467.1">
        <property type="nucleotide sequence ID" value="XM_016909294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CXF7"/>
    <dbReference type="STRING" id="692275.M3CXF7"/>
    <dbReference type="GeneID" id="27906431"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_43_5_1"/>
    <dbReference type="OMA" id="WAQTGIN"/>
    <dbReference type="OrthoDB" id="5290825at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF4">
        <property type="entry name" value="SYMPORT, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11790)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="430"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="462"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="504"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="540"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="573"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="108"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="60"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="347"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF08346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="627" mass="69311" checksum="A6DAAC9C69E30B7D" modified="2013-05-01" version="1">MESLSSSNSSSRDPLLDTSSHALLPTDAHAFIERYGLKEDDYEIFEQAATDLFLLSSDPDSHDSTTITTTTTRLLQDARNTNPIPNNPRKPESQPKTKWHHPLPLYLIVLALCLGAMSQGWSQASINGANLYYPQDFHLDNKSSTTHNTLIIGIINAAIYLSNGLVGSWLVAPLNARYGRRGATFLGGAICVVMNFLSGWSSSSWEALLGFRLLLGVGLGVVSSSLNVFAAEVAPAQIRGALAVGWQMFCAGGIFVGLGWNLVVDQYWGNYYWGQEKEEEHEAGMRWRVMLMAGAVPAVVLIVLIWWCPESPAWYVKHGEQYGKAFDSLCRIRNSKLEAARELLLAHQQQQKRPSRTNTTTTTAIQHDDDDNKNSSSSFRQTFFELYTVPRLRRATIAAYTVMLSQQLCGINIIAFYSSNIFVSAHFSPFAAELASTIFGLCNFLGALPAIFTMDTFGRRSLLLYTLPLMGLTLACTSFTFSFSSSSSSSASTTDPPHKQNFPLLTTSLIYIFCLLYSPGMGPVPAIYSAEVFPLSHREIGTSSSVAVTNLFAAILSLTFPYLLARMGTQGSFMLYAILNLVAWGLVFVLVPETKQLTLEKGLEEVFEQPTREFVRGKARRCVFWGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M3CYD8</accession>
    <name>M3CYD8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_158855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756822.1">
        <property type="nucleotide sequence ID" value="XM_016907808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CYD8"/>
    <dbReference type="STRING" id="692275.M3CYD8"/>
    <dbReference type="GeneID" id="27904945"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002865_4_1_1"/>
    <dbReference type="OMA" id="FKNITHI"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF213">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="2">
        <location>
            <begin position="422"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF08701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="721" mass="78025" checksum="FDA4704A301212C1" modified="2013-05-01" version="1">MSEIRIALLVETIDASSSSSSPVRVSVTERAECASHTSFSRKRLVRSEDDDDDDGGVVLSLVATSTDAAPSSHASFHNRHQQHKRAINETSYEYVIVGSGPGGGPLAARLAIAGHSVLLIEAGGDYGDNYNMSVPTWSLKAAEDDLIKWDYFVTHYADVERQKRDSKMVYRRSDGGLYTGREPPVDAEPLGILYPRTGTLGGCAEHNAMITTYPYRSDWTTIQELTGDDSWAPDQMRLHFQRLEKAQYPVGSGHGEDGWLCTSLTNLGLVLQDFKILSIVISATSAMGGGLLSTLLNTVTSLGNALLSDLNNDDRDRDQKTDVYQIPLAIDAETSKRSSPRGFILETANAVNADGTRKYHLDIALHTLATKIRFDQSGSTPRAIGVEYLSGERLYAADPYPSSENGSSGYIAASKEVIISAGTFNTPQLLKLSGIGPSAELQRFGIPIIKDLPGVGSNMQDRYEVATVYETEDKDRFQVSSRCTFQYNGQPDPCLDEWLAGSDVASRGPYTTSGAAVGVVLKSSAAASSEDPDLFIIGTPGVFNGFYPGFAYDSVISANKWSWLALKAHSHNSAGKVTLKSANPRDVPLIDFAYLDEGSVGYEKDLQALYEGLLWGREAFEKVNPLAGGFVEVFPGEKLQSEEELKQYAMDEAWGHHACCTAAIGAEGDPMAVLDGNFKVRGVQGLRVVDASIFPKIPGTFIALPTYMVSEKAVEAILSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M3CYR1</accession>
    <name>M3CYR1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Inosine monophosphate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_70665</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF09794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757915.1">
        <property type="nucleotide sequence ID" value="XM_016909912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CYR1"/>
    <dbReference type="STRING" id="692275.M3CYR1"/>
    <dbReference type="GeneID" id="27907049"/>
    <dbReference type="eggNOG" id="ENOG502RHJM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038732_9_0_1"/>
    <dbReference type="OMA" id="YKPAVVW"/>
    <dbReference type="OrthoDB" id="2349068at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF34">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF09794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="342" mass="35946" checksum="E711D08C07827ED3" modified="2013-05-01" version="1">MSSLQNSLPWTKSPLVINAPMGGFATAELAIAVSRSGGLGQIGSDGSMKNLEVELSKVEKALDRTEKGLLPIGVGLLSFVTERESALQIVEKYKPAVVWLFAAHKLSDYAEWAKEVRKVTSHSQIWVQIGSVAGALEIAKDTRPDVICVQGIDAGGHGWEKGAGIISLLPEVSDALAGTDIALVAAGGIAEGRSAAAAFTLGAQGVVLGTRFIAASETKINPHYRAAILAAQDGGQTTVRAKVFDELRGENIWPNAYDGRSIRTESFQDHSEGVPIDEIRRRYADAAKTDSAGYAPGIGQGRAATWAGTGVGLVHSEQPAEAIVEEIRTGIVAALEAVKARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M3CZK8</accession>
    <name>M3CZK8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_111569</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF09106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757227.1">
        <property type="nucleotide sequence ID" value="XM_016900924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CZK8"/>
    <dbReference type="STRING" id="692275.M3CZK8"/>
    <dbReference type="GeneID" id="27898061"/>
    <dbReference type="eggNOG" id="ENOG502QZDY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015590_2_1_1"/>
    <dbReference type="OMA" id="FWTKHGY"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3020.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005674">
        <property type="entry name" value="CocE/Ser_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050585">
        <property type="entry name" value="Xaa-Pro_dipeptidyl-ppase/CocE"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00976">
        <property type="entry name" value="CocE_NonD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056:SF10">
        <property type="entry name" value="COCE_NOND FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xaa-Pro dipeptidyl-peptidase C-terminal" evidence="3">
        <location>
            <begin position="318"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="214"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF09106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="595" mass="67189" checksum="765C10C49AB2B329" modified="2013-05-01" version="1">MPNKIQDLHKVDKDSFPYIYEENATITLKSSEGLVRVNIYRPKTDKPVPVLVTYGPYGKDIPYENFFPSSFAELNPEQKSTHSAWETPDPGYWTSQGYAIVRADERGLGQSPGFLDTMSKGTSEAFYEVVEWCADQPWSSGKTGLLGISYYAGTQWRVAARQPKGLSAIIPWEGMSDYYRDRCRHGGILSDKFIAFWWNRQVITNQYGRPGRKAKNWGPDTLEGDLSEEEREKNRRDQTIDNENYRFRDEDYYASKEFNLQDIKVPLLSVANWGGILLHLRGNVQGYENAGSELKYIRFITGRHDLPFYYKEEVELQRSFLDAFLKGDDRVGWSQKGKLPPVDLVLRKGDVGFNDAKAEKAFPRRTENEWPIARTQYTKYHLQPDMSLKTDAPASQSSAKPVTYKALGTLDDPQAVQFTTAPFESETEITGHVVARLSVSASAAAGGKPPSDIDLFLTLRHISPAGKEVFYTGTAGDAVPLTKGWLRVSLRKIADDHPRNQPYMPYREYKSTDVQEVKAGEVYTVDVEIWPTNVVVEKGGKLVLEVGSGDTQGSGIFQHNSKKDRSEEVFAGDNHIHFGEGMENYVVLPVIPEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-05-03" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>M3D008</accession>
    <name>M3D008_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_119564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF09823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757944.1">
        <property type="nucleotide sequence ID" value="XM_016901525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D008"/>
    <dbReference type="GeneID" id="27898662"/>
    <dbReference type="HOGENOM" id="CLU_2062929_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032666" evidence="1">
        <location>
            <begin position="20"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="119" mass="13031" checksum="BA91D911CFB4F418" modified="2013-05-01" version="1">MRATAILLTALVAILPAMGEDSKQIFGHDDPIYGDKCNPTQYAHYCAGDLLQCSGGVCDFFSCADDLDCGELPNTFCNKKFDGCTWPGGEYLTDAQKKFYYRWGEKHGDDTNGGEPPAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M3D099</accession>
    <name>M3D099_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PRA1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_50920</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PRA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF09908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758029.1">
        <property type="nucleotide sequence ID" value="XM_016909179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D099"/>
    <dbReference type="STRING" id="692275.M3D099"/>
    <dbReference type="GeneID" id="27906316"/>
    <dbReference type="eggNOG" id="KOG3142">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103851_1_1_1"/>
    <dbReference type="OMA" id="PWTVFFN"/>
    <dbReference type="OrthoDB" id="63113at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004895">
        <property type="entry name" value="Prenylated_rab_accept_PRA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19317">
        <property type="entry name" value="PRENYLATED RAB ACCEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19317:SF0">
        <property type="entry name" value="PRENYLATED RAB ACCEPTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03208">
        <property type="entry name" value="PRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF09908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="176" mass="19438" checksum="98A0E9618C693D6E" modified="2013-05-01" version="1">MARINIPIDALTSRLNFGGRFDSLRSQSVGSRFANLRPISEFLDIKRISKPQDFGMVQNRVNYNLSYFSSNYAALFVMLSIYSLLTNLLLFFVLVLIIGGMWGIGKLEGRDLDLGFARATVSQLYTALLVVAIPLFFWASPISTVLWLIGASGVTILGHAAFMEKDVAASFSEEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M3D1Z5</accession>
    <name>M3D1Z5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_109581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759639.1">
        <property type="nucleotide sequence ID" value="XM_016900789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D1Z5"/>
    <dbReference type="GeneID" id="27897926"/>
    <dbReference type="eggNOG" id="ENOG502RP5P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1595593_0_0_1"/>
    <dbReference type="OrthoDB" id="5272396at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF11518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="167" mass="18327" checksum="E80AF1170EF1B33A" modified="2013-05-01" version="1">MSSSSTTPLTQSASTPTSVTDHVAPKSFPLLDLPDELILQVLKHAVVTSSEDIVIPVLKGRRPDPPEPELHLAQPAITRVSRAFRCEGLKLFYGQNTFLSYSHISGLNNVYDWMSWGGVHPKTFVRECRGPQGIAGYQMSFGKPAKTTDKDEGGAKWLELNPEGVHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>M3D2N8</accession>
    <name>M3D2N8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_117067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760601.1">
        <property type="nucleotide sequence ID" value="XM_016901307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D2N8"/>
    <dbReference type="GeneID" id="27898444"/>
    <dbReference type="HOGENOM" id="CLU_1950171_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF12480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="129" mass="14195" checksum="BCBB1EDB31AFC6D6" modified="2013-05-01" version="1">MYNSSPNTLLRQKTQARISRSKLSDTQANLDRRTVMSAGGNVATPSSPASMYQCTDEWVLAASIELSATRHSDSGMPYKPHRLGVLVHACMRSVAFLHPDRPDAALHCAARQKPIVARMGLSEWRTKAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M3D4A2</accession>
    <name>M3D4A2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CBF1-interacting co-repressor CIR N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_149306</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760840.1">
        <property type="nucleotide sequence ID" value="XM_016905477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D4A2"/>
    <dbReference type="STRING" id="692275.M3D4A2"/>
    <dbReference type="GeneID" id="27902614"/>
    <dbReference type="eggNOG" id="ENOG502RR25">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047019_1_1_1"/>
    <dbReference type="OMA" id="KRYSAQF"/>
    <dbReference type="OrthoDB" id="2159131at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019339">
        <property type="entry name" value="CIR_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039875">
        <property type="entry name" value="LENG1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22093">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER LRC MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22093:SF0">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10197">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01083">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBF1-interacting co-repressor CIR N-terminal" evidence="2">
        <location>
            <begin position="10"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF12719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="383" mass="44695" checksum="FB4811FB4F98438A" modified="2013-05-01" version="1">MPLHLLGKKSWNVYNQDNISRVRKDEADAQARQEAAEQRMQEEDAARRIALLRGETVPPLAESRPDEEERHHCNGRSAEDEDYSTRDRKRKRRNGEDDTDRDIRYAKQAREAGLKARELLGQVNKGAERSAEAPLQDHAGHIQLFAAPDEKDIRKNQKNAEAEAEKAKKRKREEDLVTMKFSNAAGYSNGMQKPWYAAAIVDKTADKTADKTASRNEMMLAELKGNDVWGNEDPRRKERETKKIVSSDPFAAMQNAQRQLKQSEKDKERWQRKQRAELEQLRADQRRHRTIVDDADSPDEFSLDTPSLAEGPDSGSTRRRSKHRHHHHRRHHNRERDGGSRHRSRSRSRERDKIRHRSRSREREGHRSHRSRHHEQKEVDSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M3D4G8</accession>
    <name>M3D4G8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ras-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_149336</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760900.1">
        <property type="nucleotide sequence ID" value="XM_016905497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D4G8"/>
    <dbReference type="STRING" id="692275.M3D4G8"/>
    <dbReference type="GeneID" id="27902634"/>
    <dbReference type="eggNOG" id="KOG0395">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_9_8_1"/>
    <dbReference type="OMA" id="MWGCPFV"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000654">
        <property type="entry name" value="Small g-protein ras2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="194"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF12779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="247" mass="27597" checksum="1F0633A309A9401D" modified="2013-05-01" version="1">MSHGKMTLYKLVVLGDGGVGKTALTIQLCLNHFVETYDPTIEDSYRKQVGIDGQSCMLEVLDTAGQEEYTALRDQWIRDGEGFILVYSISSRSSFTRIQKFHHQIQRVKESTSAGSPTYPGSPLSQTMSSFGPAPVMLVGNKCDRVTEREVSTQEGQALAKQLGCEFVEASAKNCVNVEKAFYDVVRQLRRQRAIAPARNSKASQPADPVSRSSRTNGGEYMDREKKKRYRRSDRDRERGGSKCVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M3D4W9</accession>
    <name>M3D4W9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_149448</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761030.1">
        <property type="nucleotide sequence ID" value="XM_016905557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D4W9"/>
    <dbReference type="STRING" id="692275.M3D4W9"/>
    <dbReference type="GeneID" id="27902694"/>
    <dbReference type="eggNOG" id="ENOG502QT5J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004835_0_0_1"/>
    <dbReference type="OMA" id="RDKGTEC"/>
    <dbReference type="OrthoDB" id="5244761at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="313"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="486"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="604"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="683"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="361"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="153"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="220"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="615"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="683"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="718"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF12909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1175" mass="131420" checksum="9F244C7DEE22AF71" modified="2013-05-01" version="1">MEPYRRGYVPPTTHDHRDHHHHRHNPPPPPPPPPPHHFAPPAHPASHVPQDHQQHQHQQQQTPYRQQPSAHSQQSPQPLPLPPPPQPQPYHHHQQQQHQQQQSQSQSQSHAAAGVALPPIQPSGHPPPPSSSDPSNLPPFRPPPHEQHREESQQYQSEHSFNNRSGHATPAPLHVNRTYSQDSSHQQQQQQQQQQRTPATPTAPSHHHFSPSAEPDGAQLPPPGAPPPPHAMDHGARHGYPPTNGVLHHSLPPPAHPHHDQHPPYAMTPMMDQHHRYPPPPSGQPMYNGPPSYGPAANMNYGPKRKQMRATQACEQCRQRKQKCDEGSPCSFCKENNLNCQYRDTPPAKTDKNMEKILAYMESHERALTDLTTKIDSFEQRLRTVEQNTRSTSQNHAQTSLQTNHLYQSTGGAEQDMAMYDDSVARRSRKPDLEDHRTAPHKLLLLWPSVRPLLQAAHIAYGDGYVMEAEDRGVLRLWTKGEGIDEYDGTHAGGSASPARSEDSGDVSNAGTPSEGLWGIGFPSAPSSNSGRSDPHSYGGPKTNGYVDLDAGTINRLYESYMSNIHIMHPFLDQRRLRRMLDIFISRYSTGRHRAAFAVGNDYSGERPMKRRRSNGSGPNNVGGNNVSDSDVGCQQATERSPGNAVIYLVLALGKICLHKKALPSMVPNTRLETNLVVTHQSSAQRFQANSPMSATIKQSPMSAKSTPVTQPPPPSDAHLRRPESGSRRSSVEAPSPSADPTGLRNMDVIPGMAYYARAAEILGDQGDGNDLVHAQMFLLAGLYKGQLARVKESMSWITMAGRAILILLDRYKLYNDEYWDSRGVEVSSFQKSQARIKDTRQSLIVLASWTCLQLESDILAELRLPASGIQAIEHMLLMPHKVNEDESYSGLEPDGRLEDYDNMLIYYSAQLFLRRRLNQVHRQMYGKDSMSLPLAEVREMLTGHESILSEWRRGLPALLRWKDDDDPPKDILNARLRAKYWGARYVINRPFLDYALHVIPHVRDGKTVEEVAVDGYNNPRDKADVHLFKAIQQMGDDQIFESAHRCIYAAMKSTVAFDGIIDGGERLIVTNIHGTAHAQFGNMLVLCAVYNNNWLHNMVSGEKLKQLLLRTINFLRRLAPISPTCKADCGILEKFRNHLFPITDDAKSVYKEEGVEPASAETSFQGSFNGSIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M3D5R5</accession>
    <name>M3D5R5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ubiq_cyt_C_chap-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_148593</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBP3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761345.1">
        <property type="nucleotide sequence ID" value="XM_016905017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D5R5"/>
    <dbReference type="STRING" id="692275.M3D5R5"/>
    <dbReference type="GeneID" id="27902154"/>
    <dbReference type="eggNOG" id="KOG2873">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053729_2_0_1"/>
    <dbReference type="OMA" id="WRNLYKG"/>
    <dbReference type="OrthoDB" id="10253878at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021150">
        <property type="entry name" value="Ubiq_cyt_c_chap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007129">
        <property type="entry name" value="Ubiqinol_cyt_c_chaperone_CPB3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12184">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX ASSEMBLY FACTOR 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12184:SF1">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME-C REDUCTASE COMPLEX ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03981">
        <property type="entry name" value="Ubiq_cyt_C_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquinol-cytochrome c chaperone" evidence="3">
        <location>
            <begin position="149"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="34"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF13224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="330" mass="36857" checksum="CE250DAD10F7CD83" modified="2013-05-01" version="1">MASKNICTSCLRTLRHQGLPKQLSTRRIAAFTTSSTKYASDPKKNPYAQQPLQPPPPKDWDAHTPSTDSSPITNFAATLRSNSALRSTTEPYIAYGSTEDLFLECSKQCSYTIPSALETPPGTPPQNAAGDHLGAGVGWWLEPKSKGGLGLEVTFNSWAQVLYLHMWLLTVRLRCFPEKYVKDWHQNLLDHFFYAAEDRMATWHGMSARGVRNKNLKDLWTQWRGVQLAYDEGLIKGDAVMGTAVWRNVFKADPNVDLKDLGIVTAYIMRELQRLGKLDDMTVTEGKVRFGNPRTTVEETGLSKEAVLKQAAKSSMRVEEGGMPPEHQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M3D7Y8</accession>
    <name>M3D7Y8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Epoxide hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_162436</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762401.1">
        <property type="nucleotide sequence ID" value="XM_016908004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D7Y8"/>
    <dbReference type="STRING" id="692275.M3D7Y8"/>
    <dbReference type="GeneID" id="27905141"/>
    <dbReference type="eggNOG" id="KOG2565">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019414_0_0_1"/>
    <dbReference type="OMA" id="VGVHVNY"/>
    <dbReference type="OrthoDB" id="7130006at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF39">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08960)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="4">
        <location>
            <begin position="14"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="316"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF14280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="399" mass="45178" checksum="7CBCD9EA2FD13E1E" modified="2013-05-01" version="1">MSFDTIPSHASLKPKPFKAEVSEEDLEHFKQLLKLSKLGPKTYENQVANVKDYTHFGISRQWLSDAKEHWETRYDWRKTEARINSFPNFTVPIEEDGFTFDVHFVALFSQKPDAAPLLLSHGWPGSFLEFLGALDMLRTKYKPEDLPFNVIVPSLPGYGYSSGPPLDRNWTTEKMAAVLDKLMVGLGFGNGYIAQGGDIGSFVSRVLGVTSESCKAVHLHLVIGTQGEVDHLSDAEKKGVKRMTDFSTMGNAYAREHGTRPATIGLVLSASPLSLLAWIGEKFQQWSDETPPVDEILDSVTLYWFTESFPRAIYPYRQFFGEKPTFFHNNPAYYIKKPMGYTWHPEELAPAPRDWVAETGNLVWFRAHNEGGHFAAMEKPALFVKDMEDFVSEVWPKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M3D8T3</accession>
    <name>M3D8T3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoglycerate mutase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_131996</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762425.1">
        <property type="nucleotide sequence ID" value="XM_016902463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D8T3"/>
    <dbReference type="STRING" id="692275.M3D8T3"/>
    <dbReference type="GeneID" id="27899600"/>
    <dbReference type="eggNOG" id="ENOG502QTHF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015562_1_0_1"/>
    <dbReference type="OMA" id="CNHANDQ"/>
    <dbReference type="OrthoDB" id="10261749at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052765">
        <property type="entry name" value="PGM-Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46192">
        <property type="entry name" value="BROAD-RANGE ACID PHOSPHATASE DET1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="235"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="341"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="235"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="248"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="380"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="424"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="443"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="11"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF14304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="453" mass="52007" checksum="A3173261D2BFCFED" modified="2013-05-01" version="1">MVKPRLIILIRHAQSEGNKDRQIHQMVPDHRVKLTDEGHKQAEEAGRRLRSLLKPDDTLQIYTSPYRRTRETTEGILKTLTARDDPDDPTAAPSPFSREKIKVYEEPRIREQDFGNFQPCSAEMERMWRERADYGHFFYRIPDGESAADAYDRISGFNESLWRQFGEDEFPSVCVLVTHGLMTRVFLMKWYHWSVEYFEDLRNVNHCEFVLMNKDERGKYVLENKMRTWSELKRQKREAEARADPQRRNTLSSFLTQQTQDSPKIPPRRWGGCKDGCNHENEKFPRRAGQHQQRKQTQELVLPAPLETPKDEAADTPMAHVEAAADGANITSTTSAPQILLSSRPKPAVPEYLQPGRDGGGLSRANTPHEMNEDEDSDEYFTSSKSRTLPNAVGKAPGRQATQDDIERWTRESGMNSDKRADPLGDEPGDDTEDAENVESAEQQDKSLRGSVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M3DAU2</accession>
    <name>M3DAU2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cora-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_38322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763326.1">
        <property type="nucleotide sequence ID" value="XM_016908700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DAU2"/>
    <dbReference type="STRING" id="692275.M3DAU2"/>
    <dbReference type="GeneID" id="27905837"/>
    <dbReference type="eggNOG" id="ENOG502SS3N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1372728_0_0_1"/>
    <dbReference type="OMA" id="WWFARLE"/>
    <dbReference type="OrthoDB" id="2830640at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF15205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="23192" checksum="ABCCE5533F9314BC" modified="2013-05-01" version="1">MREKIEQQMRYSVQVQKDLNMMPRRIDNQSQAIFNFIAQRDNKINLQVAESSRKIAEESRIDNLLNVKLARVTAQMAEETRQDSAAMKTIATMTLVFLPGTAVASFFSMNGMFNWSPAAGESIASPYLYVFFAVTVPLTLLVYSLWLWWFARLEKAHKKKNLTDIDFDQYEQEVTRRMRTATSSFPVGIEKHVTIGAAQQQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M3DC60</accession>
    <name>M3DC60_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_37023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763520.1">
        <property type="nucleotide sequence ID" value="XM_016908659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DC60"/>
    <dbReference type="STRING" id="692275.M3DC60"/>
    <dbReference type="GeneID" id="27905796"/>
    <dbReference type="eggNOG" id="ENOG502S247">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040578_0_1_1"/>
    <dbReference type="OMA" id="ENEPMGR"/>
    <dbReference type="OrthoDB" id="2142040at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706">
        <property type="entry name" value="SLR1338 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706:SF1">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="43"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF15399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="255" mass="28026" checksum="DD09F055111B537D" modified="2013-05-01" version="1">MADAPPAYSPVYLPAPMGASPITVSVPEDQGADDPYSFLTSFDTIFLIDDSGSMAGSRWRETGEALETITPICTAHDQDGIDIYFLNTKDSDFHHNVTSASTVREIFETVLPGGGTPMGQRLNSILKPYLRRFQASPETVKPINIICITDGEPSDDVESPLIATAKKLDKLDAPAWQVGVQFFQVGRDEEARRHLRQLDDELAEIAGDDELRDIIDTVPFTGTEGTRLNGDGILKVVLGAVNRRLDRKKSKDLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M3DCW3</accession>
    <name>M3DCW3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_147479</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763775.1">
        <property type="nucleotide sequence ID" value="XM_016904323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DCW3"/>
    <dbReference type="STRING" id="692275.M3DCW3"/>
    <dbReference type="GeneID" id="27901460"/>
    <dbReference type="eggNOG" id="KOG1842">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026440_1_0_1"/>
    <dbReference type="OMA" id="DDVHQNL"/>
    <dbReference type="OrthoDB" id="166134at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15761">
        <property type="entry name" value="FYVE1_Vac1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15737">
        <property type="entry name" value="FYVE2_Vac1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.20">
        <property type="entry name" value="Rabenosyn, Rab binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052727">
        <property type="entry name" value="Rab4/Rab5_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021565">
        <property type="entry name" value="Rbsn_Rab-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036531">
        <property type="entry name" value="Rbsn_Rab-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510">
        <property type="entry name" value="FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510:SF44">
        <property type="entry name" value="RABENOSYN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11464">
        <property type="entry name" value="Rbsn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140125">
        <property type="entry name" value="Rabenosyn-5 Rab-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="7">
        <location>
            <begin position="353"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="593"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF15654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="670" mass="74436" checksum="7861D709FBA9FF75" modified="2013-05-01" version="1">MAARRSLGGGRVLGSGKNLAPPTPSASPALKPGLALQRPPLLSPSDSSVSLSSRASSTPITTDTEDLTSRIALDSDGVNHAAAAATNRMVCPICSEEMVTLLQLNRHIDDNHANLEQIEQQEAQDWFKQQMTKAKKFQPLALINQKLRGLEVFESNNEIAASSVTPRVLSEGREASPAPVARVSEASDPDEVVTRAHWQRSRGNDACSDPMCGKRLGPANGQVNCRHCGKLFCDEHTMYQMKLSRSAQHEPVRGLWCRVCETCYKSRPGYNDHRGLEWSHMDFFSKVRRKNVDKQYLETSRLETRLTRLTQLLADPPPMEQTPSAGTFLWSSIAGSKPQIRALEQSVVPWEDDTTVSECPFCHQPFTQYSFRRHHCRICGRVVCGDPTTACSSEIGLDVATKKPGPQNVPVDVRMCRDCQRTIFSKADFARELNAPTPDQRAYNNLMQFEQGIRLLLPKFQRLLGPLQDPDHPPSPAQLAEASKVRKRLTEAFTQYDVAARRIRDMPTESPTQERLQKAIYMQASTFLHIHMLPLKSLPKIMKHATPNGVRHAPTGSNKPQSALAAIKYDSIANGDSHRPGSSRASSVSSVAVTALEAEERELRERLIILEEQKFMVSEMIAEASKRRKFDEVSALSSNVEEISKEIDHLQAQIQAMDFAGAYAADQAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M3DDB4</accession>
    <name>M3DDB4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_106019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763940.1">
        <property type="nucleotide sequence ID" value="XM_016900604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DDB4"/>
    <dbReference type="GeneID" id="27897741"/>
    <dbReference type="eggNOG" id="ENOG502TACC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1497135_0_0_1"/>
    <dbReference type="OrthoDB" id="3630522at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF15819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="180" mass="19944" checksum="72D76EBEF0049F1A" modified="2013-05-01" version="1">MSRMSLNPIPVTERTLQRKLTTAQLQRGDSDSSTCTTSSTGSRDMATQTSEPVSSTAHSDKVVSKRSSMIRNTNSTRMSGGASHRKSVTFQPSPQISHAIEKSQTEADGFVRDKKEKKRPGGLKGNLSSLWKMLDPPELTHNTGALHNLVKAEEHNSRRKYDADATTLVETISSRQYRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M3DE60</accession>
    <name>M3DE60_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_147733</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF16055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764176.1">
        <property type="nucleotide sequence ID" value="XM_016904490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DE60"/>
    <dbReference type="GeneID" id="27901627"/>
    <dbReference type="HOGENOM" id="CLU_2185592_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF16055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="109" mass="12150" checksum="366157EEAFBE77BE" modified="2013-05-01" version="1">MALPPPVVDEISEKEKEKSVAGWSRPVNTGRYQIVDGRHGAKPRLEGHCLPLSRPQFNDDDDETMPATWAKPQVCSNCGTDRPNYLEDPRCPQCKTVEEDVDGSRDGID</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1QD68</accession>
    <name>N1QD68_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Carnitinyl-CoA dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_91676</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757316.1">
        <property type="nucleotide sequence ID" value="XM_016910566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QD68"/>
    <dbReference type="STRING" id="692275.N1QD68"/>
    <dbReference type="GeneID" id="27907703"/>
    <dbReference type="eggNOG" id="KOG1680">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_6_1"/>
    <dbReference type="OMA" id="GFAGISQ"/>
    <dbReference type="OrthoDB" id="2139957at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000074">
        <property type="entry name" value="Enoyl-CoA hydratase (AFU_orthologue AFUA_2G10650)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF68">
        <property type="entry name" value="CARNITINYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0843">Virulence</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF09195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="292" mass="31341" checksum="BFDB2AC7550901A1" modified="2013-06-26" version="1">MSSSTSSHPPPPSSPSYILSYPSPSILLITINRPQQMNSLPSAAHWEADAILTWFDDSPILRVAVITGAGEKAFCAGQDLIEQEEIRRRRETKGENEGNGNGEGRMLLMHPPSGFMGVSRRVGKKPVIAAVNGWALGGGFEICLGCDIILASPKATFGLPEASRGLYAAAGGLSRLVRLAGMTLASEIALTGRNLSAAEALHHGIINRISQTPASLVPEAIAVAEKMSELSPDAIIVTRHGLRESWELASVERASQSTDNRYGRALKEGENLKIGLRAFREKKKPKWVASKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDS6</accession>
    <name>N1QDS6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_16084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757837.1">
        <property type="nucleotide sequence ID" value="XM_016907911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QDS6"/>
    <dbReference type="STRING" id="692275.N1QDS6"/>
    <dbReference type="GeneID" id="27905048"/>
    <dbReference type="eggNOG" id="ENOG502SJFI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056960_1_0_1"/>
    <dbReference type="OMA" id="PFAWQRD"/>
    <dbReference type="OrthoDB" id="3937708at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="371" mass="39691" checksum="E9766152CBFFB09A" modified="2013-06-26" version="1" fragment="single">ICLSYGIDFQNGGSYFIDVRSSESFTVVSQFSGCEPDTAAYVLLVDNNTGDQVECSGVATTPDWTNVISTCPIAKNEMSSGTWSVLVIGNNGDGSPYAWQRDFELTVGVPVTSTTTSTVTFTETKTPSTTVTTTSTIQTTTSVPNESTITITKPAATKTITITPRAQTVTSTKWLTRTVNTWTFTQSKVTKTILPTCTIPPRPPHADPPCRIFPTIIPLPHGLTISSSKNKPRAAAAATVDPPSLTPEEKSDPTPSIQKRSPDAPTITLQAPLVLNTTTTFLSPSTSTLSEIYLTTQTKTLTDPPSTVIKASGGTKTEFTTLLPTKTKTVTRIGYSTVTRTRTVKVTWTFTTTGDVPRATKTACREEGGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>N1QE02</accession>
    <name>N1QE02_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Vacuolar serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_48541</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758607.1">
        <property type="nucleotide sequence ID" value="XM_016909073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QE02"/>
    <dbReference type="STRING" id="692275.N1QE02"/>
    <dbReference type="GeneID" id="27906210"/>
    <dbReference type="eggNOG" id="KOG1153">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011263_1_4_1"/>
    <dbReference type="OMA" id="RHPDVDY"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019863">
        <property type="term" value="F:IgE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000425">
        <property type="term" value="P:pexophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007039">
        <property type="term" value="P:protein catabolic process in the vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.80:FF:000006">
        <property type="entry name" value="Autophagic serine protease Alp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000007">
        <property type="entry name" value="Subtilisin-like serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8 12" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013084945" evidence="9">
        <location>
            <begin position="16"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="11">
        <location>
            <begin position="40"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="10">
        <location>
            <begin position="173"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF10486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="498" mass="53393" checksum="D431484F49B10056" modified="2013-06-26" version="1">MKGFFSLSAAALAAASPMMVIDSDAAPLISSSNAKEIPGSYMIKFKKHVTTNLAAEHHDWVQDLHYTTQQAKTDLRKRSQSPMVDDIFQGLKHTYNIAGSLLGYSGHFDDETIEQIRRHPDVELVEKDQEVHTLGDKPEEVEKNAPWGLARISHRDSLSFGTFNKYLYAGDGGEGVDVYVIDTGTNVDHVDFEGRASWGKTIPSGDADEDGNGHGTHCSGTVAGKKYGVAKKAHVKAVKVLRSNGSGSMSDVVKGVEYAAESHSEQVSIAKKGKRKGFKGSTANMSLGGGKSPLLDQAVNAAVDAGIHFAVAAGNDNADSCNYSPAAAENAVTVGASTLADERAYFSNYGKCNDIFAPGLNIQSTWIGSKYAINTISGTSMASPHIAGLLAYMLSLQPAKDSAYAVADITPKKLKSSLMSIATEGALTDVPSNTKNILAWNGGGISNYTDIVEKGSYKVHQTERKVSEKTTDFAEKLTELEQKLETDFKDLLRELKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>N1QEF9</accession>
    <name>N1QEF9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_120200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757463.1">
        <property type="nucleotide sequence ID" value="XM_016901580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QEF9"/>
    <dbReference type="STRING" id="692275.N1QEF9"/>
    <dbReference type="GeneID" id="27898717"/>
    <dbReference type="eggNOG" id="KOG0235">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033323_13_2_1"/>
    <dbReference type="OMA" id="DYEGMTT"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF09342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="114" mass="13085" checksum="1F53E514CD6AFA34" modified="2013-06-26" version="1">MLREPEWAKSGRYTSFTELDLTPEGVAQVFSTAALLVGKSKLIDPHRLAPVVASPRTRARTTLKLLFSADIIEETVIFTEDITEEWNHGAYEELKKKEEILRLRKDKSLKNDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1QEL4</accession>
    <name>N1QEL4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable lysosomal cobalamin transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SEPMUDRAFT_127450</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Probable lysosomal cobalamin transporter. Required to export cobalamin from lysosomes allowing its conversion to cofactors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LIMR family. LMBRD1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758976.1">
        <property type="nucleotide sequence ID" value="XM_016902146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QEL4"/>
    <dbReference type="STRING" id="692275.N1QEL4"/>
    <dbReference type="GeneID" id="27899283"/>
    <dbReference type="eggNOG" id="ENOG502QQ2T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028341_1_0_1"/>
    <dbReference type="OMA" id="FWAQFVF"/>
    <dbReference type="OrthoDB" id="73273at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072665">
        <property type="term" value="P:protein localization to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050854">
        <property type="entry name" value="LMBD1_LysCbl_Transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006876">
        <property type="entry name" value="LMBR1-like_membr_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16130:SF2">
        <property type="entry name" value="LYSOSOMAL COBALAMIN TRANSPORT ESCORT PROTEIN LMBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16130">
        <property type="entry name" value="LYSOSOMAL COBALAMIN TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04791">
        <property type="entry name" value="LMBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="10" id="KW-0170">Cobalt</keyword>
    <keyword evidence="9" id="KW-0458">Lysosome</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="190"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="376"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="418"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="514"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMF10855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="594" mass="66658" checksum="4EE0048D86331908" modified="2013-06-26" version="1">MALIETSLIWVAYAVCLAIIFFISAIFVYVYQKPGERTVAVTLICQITILALLATVLLMPVDVALVSSTTSRKLGRKKDWATPDKVDDTLYTLKIVYYTLYSLDAVLCLLVVPFTYFYYEEYDEVATEEGQQTIGSRLWAAFKWTIAFIVFCVILFLVGFFVPVTKKARDDHKDLDFFRDLLTENHGERALTFAIGVLILIGTILYCLYTAPGLALLPVSLIKSAPSISTPQLAETTESQLAQNRERQRQLEGRSEGREGGLDGRDRRELEALNREERTLIRRQRLAEENAGTDRNWIVKVWLKMEAVFRPLKLLFGLLLVVVALVIFASMLITMVDKIKNSVCGVSCAYLLGKTKIFQPINALLRETSKIFPIDYVIFLLLTVLFFCASVVGLATIGIRFLWVMLFRIRKGHTTPNAMLMATVMLTLMTFALNYSLAMIVAPQYVTFGAQTYCDRPTGNPEQQPDCSQHHSAIKPCSERSDNPVAKMVCTPSVVSTFLNRITANFPYLGVVDFYAQFAFLGIFIIVFLVTLFRVPKLDEEQMDEDLQEAEEEGLLASTGRRFGATWQDITGRSKGVKRSNYGALSGGVANGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2023-02-22" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFR8</accession>
    <name>N1QFR8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_109879</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758713.1">
        <property type="nucleotide sequence ID" value="XM_016900812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QFR8"/>
    <dbReference type="GeneID" id="27897949"/>
    <dbReference type="HOGENOM" id="CLU_1090582_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF10592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="255" mass="28100" checksum="56EE8733DFF9B217" modified="2013-06-26" version="1">MIDRPEWSLCKKKKKKTSVSHSKYDLKKLVDRPLFEYVSTLPSPAQPSPAPAFSANTHVGSQNVREGCPNNTQQSCVIKDSQESVFWSRMFGGKLVGSAASRMDATWKRPYTQYSISMSNMHMAATSLPVKMTWKEKPSSASPQSSECRKSPNLTATFPLGVGSYYFTLVCGSGSQSVLRYRTAQKLVIQAQNLGRVQRARLPSLNMDNGLDQEIDIQLARHHDSANHIVSFPSLLGTDQTSSSSSSSSPLSVVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFT0</accession>
    <name>N1QFT0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_109890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758728.1">
        <property type="nucleotide sequence ID" value="XM_016900814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QFT0"/>
    <dbReference type="GeneID" id="27897951"/>
    <dbReference type="eggNOG" id="ENOG502RKVB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_900239_0_0_1"/>
    <dbReference type="OMA" id="THACEHA"/>
    <dbReference type="OrthoDB" id="2214at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110286" description="Apple domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF10607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="311" mass="32850" checksum="90DA00C856EF3B66" modified="2013-06-26" version="1">MLFLALPSLFAALSYALPQEAACATITKQIIVPTRTATYWSTAIVTVSPTTAKNLGIFTLITTISDTTTVQTLTSTTTSCAASGTVFVPVSTTTVYGKSNFAKRQLGLNPRQYADCTTTVTSYTTYGQTYTWAPAGETATFYDYSAFSQTTVTSVKTGGRAFAIATSMVTKPVTCGTQTITQKGQTSTVTLDPKCSPSSMISQYNDYGISYLSDTPSAGATWKTSTTDASQCCQLCATSWQCASSAWDIRSGECRLEFPVTWNTGDLNCGNGLLAYYDAGPANPMAPGTGWYIAKLCGDATFGAAQPDDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1QG57</accession>
    <name>N1QG57_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_149979</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760398.1">
        <property type="nucleotide sequence ID" value="XM_016905889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QG57"/>
    <dbReference type="STRING" id="692275.N1QG57"/>
    <dbReference type="GeneID" id="27903026"/>
    <dbReference type="eggNOG" id="KOG1289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004495_2_3_1"/>
    <dbReference type="OMA" id="WFNNFVG"/>
    <dbReference type="OrthoDB" id="2417308at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF22">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="411"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="434"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="476"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="507"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF12277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="565" mass="60710" checksum="C2E1C18A28D2466D" modified="2013-06-26" version="1">MDIEANTPTPTPSKPTAPTTKPSTSTTSLQPTSSSPALETGIITPLLTRKFDLKSMLALSFSVLGTWGTLAVGLSSGLSNGGPISILWGFVLVFLCNVCIALSLGEMCSAMPTALGQAYYVHRLLESGDGSGGGGGRGGGRFASYMCAWINTFGWWTLTASQVAFMTEFMLGIKVMFSAEWTGAGKGWVQFVLYLGITGLFTVVNIISCRRDEILPIFNDIVGAWFLALFVIISLALLISVGTRDGMQFQEASFVFGQWLNETGWGDGVVWFTGLLQGAYGLTAFDAVIHLVEEIPQPRKNAPKVIWLAVLIGAATGWVFMVVCLFSIQDLATVIDGPTGLPFTDLIQQTVGLQGGCVLLVLFVVNGLGQGVSIATTGSRLTYGFARDAGIPFSAYFSHVDHYWKVPARSLWLQGLLVGLIGILYLFASTVLEAILSVATIALTISYGMPILALLLAGREKLPPGGTFHLGKWGPFINWVSVIYCSITTVFFFFPSEPNPPAADMNYAIAVFGIMLVIALGFWFIAGRKTYLMTDDAAMRIEMARRLEGEEDLSDAVVITTSKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGH2</accession>
    <name>N1QGH2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF572-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_145587</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWC16 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764422.1">
        <property type="nucleotide sequence ID" value="XM_016903145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGH2"/>
    <dbReference type="STRING" id="692275.N1QGH2"/>
    <dbReference type="GeneID" id="27900282"/>
    <dbReference type="eggNOG" id="KOG2990">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050402_0_0_1"/>
    <dbReference type="OMA" id="YDDAMYK"/>
    <dbReference type="OrthoDB" id="360327at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007590">
        <property type="entry name" value="Saf4/Yju2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111:SF2">
        <property type="entry name" value="SPLICING FACTOR YJU2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04502">
        <property type="entry name" value="Saf4_Yju2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="238"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF16301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="32652" checksum="ACBDDAF8D1542FC5" modified="2013-06-26" version="1">MQGFNMGRYVPPHLEGTASGNQLHKKRAPGMLKNGAQTVRFEMPFAVWCHTCKPHGIIGQGVRFNAEKRKVGMYYSTPIWSFVMRHPACNGTIEIRTDPKNTAYVVTEGGKARDYGDPTDRVREGEGDVPILTAEEREQRREDAFAQLEGKVEEKQQTQDTAKRIQELYKIGERDWEDTWNANKRMRESFRRDRKALKRRELADQQIKDRIGTDIELLPETEEDGIRAKLVSYGEDIGKSQTDVASTKPVFRLPDKKPAKQTKSTSKDTLRARLLANTRAKTNPFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGR4</accession>
    <name>N1QGR4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_134732</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758459.1">
        <property type="nucleotide sequence ID" value="XM_016902658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGR4"/>
    <dbReference type="STRING" id="692275.N1QGR4"/>
    <dbReference type="GeneID" id="27899795"/>
    <dbReference type="eggNOG" id="ENOG502QV0E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042117_0_0_1"/>
    <dbReference type="OMA" id="HANMLLV"/>
    <dbReference type="OrthoDB" id="6357136at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032063">
        <property type="entry name" value="MavL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16062">
        <property type="entry name" value="MavL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF10338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="340" mass="37979" checksum="D89613C3244E8976" modified="2013-06-26" version="1">MGEKDFTVLRDGRKISDGAREEWDRNGKDEGMKKNRFLRDLREYLSYDEMMLGSLMGVSGPSYFINRGGRLNGGKLETGAEWERRGIIMGLVGARFERKERMDSIFMLTGEKKKKSSPYQMHPHLQEIFCDFFGVEPMDESLAAGNTLDRRMFEARMRIPAEMLLLEAHDRVQQADPVGEAGQTAYVYVVGLGLGVWMHSAAQKDIFIQAFAAAIDTLPSQHRISTIEFAYMPAIAPTVRAHVEKAASRKGIRIRFTNGRDPADKLTGSDEGKLLVVSYAWDANAFPGNEYWQGSLSASGDPAAACMSTIAQLHNPIINPGYLSRIHIAGRGKFVVHREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1QH36</accession>
    <name>N1QH36_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_145730</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764616.1">
        <property type="nucleotide sequence ID" value="XM_016903231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QH36"/>
    <dbReference type="STRING" id="692275.N1QH36"/>
    <dbReference type="GeneID" id="27900368"/>
    <dbReference type="eggNOG" id="ENOG502SMZV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036632_1_0_1"/>
    <dbReference type="OMA" id="PIWFISK"/>
    <dbReference type="OrthoDB" id="3918601at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39614">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39614:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="3">
        <location>
            <begin position="35"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF16495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="401" mass="44922" checksum="F9AB2DEB675F3D8C" modified="2013-06-26" version="1">MNSGFVTPTAIDVRAWLWVASFLSFVYSVLCLAARFVGKWDMLWWDDLVLGAGYMASVVHWGMLFHAIAKGLGIASIAISSSDLSFAARVYFGSRIAFFAAHCLSKLSIIVFTRRIFSGDIYKEKVLFGIAYAMIVLYGIAGILLSSAGCRPDETLVARVDAVCDANTARWAVITVWDCLTELIILAMPIWFISKNQLKASKKRIVIFVYMFRLIVIAFSIATTVSYFNFLHGGGNSISISPVVAWQEVHLGFSLISASFPCLRTFLWAFMSRGVLTMYGNTTVSHSESRSQGASLQLRSMTKSQTEQQQQQQPPPPPPLNSDRPRLRPESQFEYSVHVRGDAPESTGKNNNSSTRRKKFPHHDLYISRKKSDDSDQMIIRQETSYRVESSSFSTYLCRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1QH45</accession>
    <name>N1QH45_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lytic polysaccharide monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_23351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764626.1">
        <property type="nucleotide sequence ID" value="XM_016908370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QH45"/>
    <dbReference type="STRING" id="692275.N1QH45"/>
    <dbReference type="GeneID" id="27905507"/>
    <dbReference type="eggNOG" id="ENOG502RZYG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032571_2_2_1"/>
    <dbReference type="OMA" id="PCRGHHK"/>
    <dbReference type="OrthoDB" id="2342176at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110324" description="Lytic polysaccharide monooxygenase" evidence="1">
        <location>
            <begin position="24"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF16505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="24829" checksum="C04A710FCD3CB9D6" modified="2013-06-26" version="1" fragment="single">MASISKSHSFWTLCGLLLWPITCLTHMEMDWPYALRSKHNPDNDYSNIDYSMTSPLNADGTNFPCKGYQNDRPFQSVTTYTAGSTYNISLAGSATHLGGSCQIALSYDNGATFRVVKSIIGGCPLSSSYDFKIPSFAPSGYALLSWTWQNHAGNREFYQNCAQVKVISSASRRLRRQSFHSFNSLPFIWKANLEGLNDCATAEGSDPVYPKPGPDVVYAGDVTASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1QHJ1</accession>
    <name>N1QHJ1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PAC1-like LisH-like dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_145880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764812.1">
        <property type="nucleotide sequence ID" value="XM_016903316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QHJ1"/>
    <dbReference type="STRING" id="692275.N1QHJ1"/>
    <dbReference type="GeneID" id="27900453"/>
    <dbReference type="eggNOG" id="ENOG502S696">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048446_0_0_1"/>
    <dbReference type="OMA" id="MKVIIVR"/>
    <dbReference type="OrthoDB" id="1932312at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056795">
        <property type="entry name" value="PAC1-like_LisH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24951">
        <property type="entry name" value="LisH_PAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAC1-like LisH-like dimerisation" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF16691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="463" mass="50263" checksum="308D4C8B56E7A276" modified="2013-06-26" version="1">MPSVDSPTLIVARYLKSNGYTETYEAFIAEAGLPQDAGVVVKGQLDLETLLDEKKNFDIAVKFEKLGLENANTGWKQPAPSNARIIDELPTSSNILSARVEEFKDQDGNEQPLLLATTADKRVHLINANNNALQASYATIHDAPALSALKIGDNTLITSSMSGQLHLSDLSGKCFAKRRDHSKYVVKVAVFEDKLHGSVIATAGWDNKVVIYHVDSTDDDLQLNEPSATIPLQTKPEAMVFVRHPETNLPVLILSRTDSNNIYYYTIETQPRLLGQQNLAPHSNAWVAFTPSALEICPTDPTLLAVGTSSIPHMKLLLVRLLFPSWEPEPPRPPPTALRTSLLDDDAPAQQETQASQARAALVIAEREFAAIQIHATTMAPQTPYSTPAVAWRPAGDGVWVNGDDGAVRGIEASTGKVVSTLRGHEPGSKVRCLWAGHVPGVGEMLVSGGFDHKLILWTSVPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1QHX3</accession>
    <name>N1QHX3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glycoside hydrolase family 28 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_137588</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764972.1">
        <property type="nucleotide sequence ID" value="XM_016902843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QHX3"/>
    <dbReference type="STRING" id="692275.N1QHX3"/>
    <dbReference type="GeneID" id="27899980"/>
    <dbReference type="eggNOG" id="ENOG502QRJW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016031_1_1_1"/>
    <dbReference type="OMA" id="NITFRGW"/>
    <dbReference type="OrthoDB" id="3684889at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF8">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_7G06410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF16851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="427" mass="46910" checksum="01E184D0C6EAF32A" modified="2013-06-26" version="1">MVAWPWTQAVLASSTITPNRAPFSIPGPETRTKICHIQPAENGGDSTPAILSAFERCGHNGNIIFDNVTYHIESVMTTIGLANVDIDIRGTLLWGTDIQYWLQNSLAIHYQNQSTAWYLGGDNIYLHGNGFGTFDGNGQAWYDFTNGASNYPRRPHQITFGGLTNSVIENMRFVQSQMWTMTLINSNNVLLQDIYINSTNLKGGDQFGPLNTDGADTIYSNNITFARWTVDCGDDNISQKANSTNIWIEDCTFYHGSGIALGSIGQFKDQYEFIENVTARNIEMHGPIRQGGYIKTWTGVQKGFPPNGGGGGLGYIKGITFDNWTLHDAELALDITQCVNFEGGTGDCDTSTFEISDLRWHNIRGTQKRLQAVDIQCSAAAPCHDINITNVEMTLADTGAPATEYQCSNVVHPIGFVCDGTTAKMIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1QIA0</accession>
    <name>N1QIA0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA sliding clamp PCNA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_150852</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Involved in DNA repair.</text>
    </comment>
    <comment type="function">
        <text evidence="7">This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processivity during elongation of the leading strand.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the PCNA family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759019.1">
        <property type="nucleotide sequence ID" value="XM_016906437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QIA0"/>
    <dbReference type="STRING" id="692275.N1QIA0"/>
    <dbReference type="GeneID" id="27903574"/>
    <dbReference type="eggNOG" id="KOG1636">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043978_3_0_1"/>
    <dbReference type="OMA" id="EMKLINM"/>
    <dbReference type="OrthoDB" id="534348at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043626">
        <property type="term" value="C:PCNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030337">
        <property type="term" value="F:DNA polymerase processivity factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034087">
        <property type="term" value="P:establishment of mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035753">
        <property type="term" value="P:maintenance of DNA trinucleotide repeats"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000710">
        <property type="term" value="P:meiotic mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903459">
        <property type="term" value="P:mitotic DNA replication lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045739">
        <property type="term" value="P:positive regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045740">
        <property type="term" value="P:positive regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00577">
        <property type="entry name" value="PCNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.150.10:FF:000006">
        <property type="entry name" value="Proliferating cell nuclear antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.150.10:FF:000008">
        <property type="entry name" value="Proliferating cell nuclear antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.150.10">
        <property type="entry name" value="DNA Polymerase III, subunit A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00317">
        <property type="entry name" value="DNApol_clamp_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000730">
        <property type="entry name" value="Pr_cel_nuc_antig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022649">
        <property type="entry name" value="Pr_cel_nuc_antig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022659">
        <property type="entry name" value="Pr_cel_nuc_antig_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022648">
        <property type="entry name" value="Pr_cel_nuc_antig_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00590">
        <property type="entry name" value="pcna"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352:SF0">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02747">
        <property type="entry name" value="PCNA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00705">
        <property type="entry name" value="PCNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00339">
        <property type="entry name" value="PCNACYCLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01251">
        <property type="entry name" value="PCNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00293">
        <property type="entry name" value="PCNA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA N-terminal" evidence="9">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA C-terminal" evidence="10">
        <location>
            <begin position="127"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00054163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF10898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="259" mass="28636" checksum="27F3E3FA9A8C9000" modified="2013-06-26" version="1">MLEARLEQAALLKKVVDAIKDLVQDCNFDCNDSGIALQAMDNSHVALVSMMLKSESFSPFRCDRNIALGINLTSLTKVLRCAQTEDILTMKAEDAPDVVNFTFESAESDRISEYDIKLMDIDQEHLGIPDTEYSATIALPSSEFQRITRDLSALSESVSIECTKDGVSFKCNGDIGNGSVTLRSHTNVDKPDNNIEINLTEPVALTFSLKYLLNFCKASGLSQQVKLCLSNEVPLLVEYGLSNNSYLRFYLAPKIGDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>N1QIK1</accession>
    <name>N1QIK1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_17832</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760375.1">
        <property type="nucleotide sequence ID" value="XM_016908300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QIK1"/>
    <dbReference type="GeneID" id="27905437"/>
    <dbReference type="eggNOG" id="ENOG502S56Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1777393_0_0_1"/>
    <dbReference type="OMA" id="SWGALTR"/>
    <dbReference type="OrthoDB" id="4094614at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="2">
        <location>
            <begin position="27"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF12254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="129" mass="13478" checksum="DAFD562993787916" modified="2013-06-26" version="1" fragment="single">LLSGLLSLANAFTQPQSSPTWGALLAPDSSNPVTRGQDFVITWDPNYGGVTRPVDGVTVSLVLCRGNSNNCALGQTAIVEGIPAGDKQYTWSVPCDLPAGEANTDTGNGMLIIVDGTGEFQYSTQFSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1QIY0</accession>
    <name>N1QIY0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_149662</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759896.1">
        <property type="nucleotide sequence ID" value="XM_016905696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QIY0"/>
    <dbReference type="STRING" id="692275.N1QIY0"/>
    <dbReference type="GeneID" id="27902833"/>
    <dbReference type="eggNOG" id="ENOG502RYPI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_13_4_1"/>
    <dbReference type="OMA" id="GEWVHWE"/>
    <dbReference type="OrthoDB" id="2152029at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="5">
        <location>
            <begin position="145"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF11775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="384" mass="43047" checksum="68B02FEB0B1BCA32" modified="2013-06-26" version="1">MAVNPASTPANMAFDAQTEPYININSDIHSSQPTIHVTKRHDRSTLMMLLQLLIKPFAAQLVSNDTVFPAGSPQLTPHKRATKRCRVQERKVEEIYLYDIVPTVGKKSKLGVAQKRMPGETTTEPAAAAAGGIKEEEEKKKKRRVYYYSGGGWQSPANSEHWFFVSELAKQLHPHGYTVTLVSYPLAPNSAAPTSFPAIMRQYRALMELAEEEDEEVVLAGDSAGGNIVLAVLIQALMEDERDGIERPTCTSVMAISPSTDLTRSNADMHSIAKKDPILRVPFVIDTAKKWCGEWSPQDVRVSPLYADLQCIRKRGVKVHGVVGRYDILSPDAILFREKCNQARIQGEWLDWDKQIHVFPLIFRYGLREGHAGKDWVLDVLRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJ52</accession>
    <name>N1QJ52_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CwfJ_C_1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_32306</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWF19 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765336.1">
        <property type="nucleotide sequence ID" value="XM_016908490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJ52"/>
    <dbReference type="STRING" id="692275.N1QJ52"/>
    <dbReference type="GeneID" id="27905627"/>
    <dbReference type="eggNOG" id="KOG2477">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015540_2_1_1"/>
    <dbReference type="OMA" id="FMKCLTR"/>
    <dbReference type="OrthoDB" id="2113965at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040194">
        <property type="entry name" value="Cwf19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006768">
        <property type="entry name" value="Cwf19-like_C_dom-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006767">
        <property type="entry name" value="Cwf19-like_C_dom-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072">
        <property type="entry name" value="CWF19, CELL CYCLE CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072:SF5">
        <property type="entry name" value="CWF19-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04677">
        <property type="entry name" value="CwfJ_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04676">
        <property type="entry name" value="CwfJ_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cwf19-like C-terminal" evidence="4">
        <location>
            <begin position="442"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="Cwf19-like protein C-terminal" evidence="3">
        <location>
            <begin position="574"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF17215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="684" mass="78321" checksum="2A99D25133600D00" modified="2013-06-26" version="1">MAATLEEFERQLASSKSRNDDDDYGDREAAAGDSDRKHHREHRSRHRDGHDDNEQRHRHKRRHRDRDHDDDNESRRKRHQSHSPREVKHAPAKDGTKAQRDAWMQDPAALEVDYVQRTRPKSPPGQFVGAKQSHDFKVTDQQFNEHLAELQNDCDSNGDDDAEKVKDEPAQHYVKYTFGDNGSSWRMTKLKGVYRKAEETGMDLDVVAEESYGDLRLFDDAREEEREVNRRAMYGKEYIGRETPSGELFAERKLRTVVRRETEDKGRGAAYPADGGHMRAAKAPLQSAPFDQSALNKWKAQLIKAKLMNASNVAQLEEEYTLAETAFLAHRAHPGVVVLNDMENRMLAGDRSGEVTALTGKRALERGTVQENEDMSIEEMVKQEKRTRGANGGEGRAFAERIAKDGKFKDNLEYMDDNAAHLSKRVVKSDTNLRNAAVGDFQRMQRTLDNCPLCYHEDSSAPPVAPVLSLATRTYMTLATEPEMAKHGAVVVPIQHRLNLLECDDDEWEEIRNFMKSLTRFYHAQDKSVIFYENAAHMHSRKGHAALMAVPLPHHLAENAPAYFKEAVLASDEQWSQHKPIIDTLALTQKAGYGKAAFRRAMVKEMPYFHVFYTLDGGMGHVIEDERRWPKGDLFAREVLGGMLDKGPEVIKKQGRWERHDRRVDSFKKKWDPFDWTKVLMEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJF4</accession>
    <name>N1QJF4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_146403</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7 8">SO2202</strain>
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        </location>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <sequence length="946" mass="107029" checksum="ADB2FF22AD4AEACE" modified="2013-06-26" version="1">MPRYKRTAETAQLEKALEPTIAPETQAMRATLRNMWEFASLMQYIFLFGHVVKIDDDLDIEDLEHECLQPTPSEKLARIGLQLLKYVSSHRGLTLEIFDEYTRRQYLAKAPHRNPFGDDEEPTKFNDLDIYTRVKVLQQLSVWTLGNAERIRGMMPQEEDHLSWRIEPLGWDKEDRSYYVLDDNRLYRRTDEPPPPPTPQPKIKAKSASKSKRKTPSRGTRASKRRKLEESEDEELEEQPEADNTAIEDTLMTNGGDETAPEDPDSAGYGFTRKTWELVAVTLEEYQEFMASIFRSRDPNEKQLRATIEEDVMPIIEKRAEALQAKRMKKVRELENLQKMATAKRSSRLADKADKEAEARKEREAQEQRQHELKLAREEQERQKRIEEGHESRRLTREQRVREREAKRILHEEELARLEAEGERAGSQDVPNDDADADAKRASGRQRQTQREKHKKELEKLAAEDGSWYFDCSVCGQHGENMDDGSHSIACDRCNVWQHSKCHGYTPKQAEQETFTFICGTCKRKEADAQKPKIPPLKLHNRSSDTPETQKSGSRPVTANGQHMQQLYTSYYPGTGPQNTADYQKSPPAQMQTQIQETAGYRYPPVSNFAPRSVQVPQSNGQPNGPRSQAQLPLTNGNGQRAPSHHQQHQYAHNSAIATAGGHPPQAQHMFPHQQQHSHNPQQWQHYQQPNENLHMQQRPGSSQLMNGFQSPSKAAAKPPSPSPNQLNMAAPSYTPQPQWQPQHPYQPPQQMQTNNFAQQMQRSPDLAPPPIQRQQQSPVKSSPPRSAHLPMSSAVANYQQHYASHVQTPQMRESHANGASPNATQVAVDGMSGPWPSRSNDIPRKHDQPQSPVPPPLAQRVGDQRVLPPVTPLAPSPGQQSATAASSVPVKKMQLSPVMSSAESVGLPPVLSPPAPIIRPQIQAQPPPTPVTVHTQPGAMHETKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1QK51</accession>
    <name>N1QK51_SPHMS</name>
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        <recommendedName>
            <fullName evidence="4">Abscission/NoCut checkpoint regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_143537</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">SO2202</strain>
        </source>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Bbox1_ANCHR"/>
    </dbReference>
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        <property type="entry name" value="ABSCISSION/NOCUT CHECKPOINT REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46603:SF1">
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        <property type="match status" value="1"/>
    </dbReference>
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        </location>
    </feature>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMF10944.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="358" mass="38772" checksum="A5165675F0154BA3" modified="2013-06-26" version="1">MPGQDDDLLARLNALKPSSVNLEAVAPSIDVQTSQPQTIEDKLAERLKTLRSGGTPSPIRRPEAANSATPLHRPESVQTQDVSAVPTDPIRNWQQPHGDEQSVEDLLAELEADGQWRLDPEEPKSVEALLTEAQQALPKNSGLHTPDGQREDHDSREHGDHVDGNGHESEQTDDQHDEAEADDYIARVLAELDIEKKYGGGGEGDEKPEQPPRSSQDATDLNDGLDLPSTPSHLKESPNPSDHQPHTSEDSELEARFSKLGMGSLGLPSTPTSAPSSKPKVVASLKPANRTTLPTFTDEEIDSWCCICNEDGEVRCLGCDGDLYCHSCWSDGHGSGPGKEKGHKAVQFNRKPPKATVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1QK87</accession>
    <name>N1QK87_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Smr domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_146587</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765731.1">
        <property type="nucleotide sequence ID" value="XM_016903750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QK87"/>
    <dbReference type="STRING" id="692275.N1QK87"/>
    <dbReference type="GeneID" id="27900887"/>
    <dbReference type="eggNOG" id="KOG2401">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023589_0_0_1"/>
    <dbReference type="OMA" id="ELENEYC"/>
    <dbReference type="OrthoDB" id="443981at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052772">
        <property type="entry name" value="Endo/PolyKinase_Domain-Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058864">
        <property type="entry name" value="UBA_10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46535">
        <property type="entry name" value="NEDD4-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46535:SF1">
        <property type="entry name" value="NEDD4-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26286">
        <property type="entry name" value="UBA_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Smr" evidence="2">
        <location>
            <begin position="455"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF17610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="545" mass="58463" checksum="E3318719F5F6A2E6" modified="2013-06-26" version="1">MGDTLALLEAVYCPPLDPALLSAILSDYDLENEDQLREARGALDQLKESAELEEHAGFDASGTGGRDNEVRHGSSSRPESCPEETNTTVSRETDLTNLSAEWQSLNLNSTSAEVPSGNGDIAEELENLNEDAKIALLEQIMGQQLSRYTVQHTLRKCKGNWHKAMDELLSQVYMHEAENSDGDGKLAVKSIDAFSEENTSRRGRKGKGKKKGAKLNDSGRSSSLPTSPVESEPTVANAWQGAGRDIEFIASRTGEPSKTVATIYYNSGASRAKTIGSILKNHISEGTIALAEDPIKAVTAHDLGQDFPSIDSQYVASLINLTYPSTAAARELAEALTTRPSIEGGIEIIPTYVRPNIEEADAFSPVAGRNKPASGHAYSSNVSDARERASNYAAARSAALAQAYAAHRKAKSDRLMGGVAGYYGQVSRDYYALSSAASAAAADEMAASQSSASEVDLHGIDVLNAVRIARERVEQWWEGLGENRANGRIGANQRQAGYKIVVGLGRHSEGGRSKLGPAVRKMLTEQGWKNELNGAVITVQGRARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKM6</accession>
    <name>N1QKM6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_56594</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764958.1">
        <property type="nucleotide sequence ID" value="XM_016909406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QKM6"/>
    <dbReference type="STRING" id="692275.N1QKM6"/>
    <dbReference type="GeneID" id="27906543"/>
    <dbReference type="eggNOG" id="KOG4442">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029124_1_0_1"/>
    <dbReference type="OMA" id="IWRQLHS"/>
    <dbReference type="OrthoDB" id="10261904at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053105">
        <property type="entry name" value="Class_V-like_SAM-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47250">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SET-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47250:SF3">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SET-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="465"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF16837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="604" mass="67657" checksum="28DDCD67A22CD88A" modified="2013-06-26" version="1">MTDSDVQSLARDIGARITEELPNILRQLLTEQNLSSGPLQFECSLLSGQQDQQHTVRLAAVDITDITDVGTPSTTAATTTTTLSRSGSRDARPRDAATLNEGADRASKRRATCDLRIGQGEGESGPQIPDSSSPSSAVIRRLESDVRIFPQRKKRLLPENPNLQPSSLDKLIHGIWDSIYAATPLDPAEVIRQWHAIEPGQSGALLDVGVNAVSGRDDTVRTVFGKMNLLTRMVSQVSRTYRSLEVLVQAQWTQSFDERVAHLSSSMTSEKAKKACLKEACVDFGWTEKELRNKMAIWRGYHDIKSCGGWAALIFSGMGLYRFCKYRVSFTEETYQTLRSLRHRFEVAADCLHPRWRQLLAIVGEPLERKYEGHPHDWVVCGPGDEAIPLPVTYQKWDKSFTYTHLDESLIDEDAWGMYDPRTVTPLTDPAAYECQSCGEKQSDDSRQNNCMCFPNYYGTKARSIPVQVYRTPNGKNNGLLACCAFEQGAAIGEFIGEITSGVENKDVMIGQTDRAVYQIWQGKSGNYTRFVNHSCAPNSQFERFVWLGKQRIVLVSKGVEAGEEITVDYSDTYWKNLNKKCLCESSKCRYRRQPELLTVSGVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKR8</accession>
    <name>N1QKR8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phospholipase/Carboxylesterase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_45785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759897.1">
        <property type="nucleotide sequence ID" value="XM_016908977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QKR8"/>
    <dbReference type="STRING" id="692275.N1QKR8"/>
    <dbReference type="GeneID" id="27906114"/>
    <dbReference type="eggNOG" id="KOG2112">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062889_1_0_1"/>
    <dbReference type="OMA" id="VMQFFAR"/>
    <dbReference type="OrthoDB" id="437457at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF67">
        <property type="entry name" value="PHOSPHOLIPASE_CARBOXYLESTERASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_5G09340)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="2">
        <location>
            <begin position="23"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF11776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="259" mass="27607" checksum="4DB350A83E063249" modified="2013-06-26" version="1">MGRLPTTDDFPPKVHVNIVPPPSSDAPTNILILLHGLGDTNASFTQLASQMQLPETCCISLRGPQPLLDLGGFHFGDDILFSTTSPHGSDSDGGGIDMDSGFSQISSLISLIIHEVLITKCQFRLREIFLFGFGQGGMAALSTAVAIDGAHVAKDPLLVELGGVISIGAGLAAETPAELDPKCRTPVLVCAGSADGGSVVTRGTEEKLRRVFGFVEVRRWRRAGDGMPRDREEMLPIMQFFARRLRSVKGVPKGAVELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKV6</accession>
    <name>N1QKV6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_146805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016766017.1">
        <property type="nucleotide sequence ID" value="XM_016903877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QKV6"/>
    <dbReference type="STRING" id="692275.N1QKV6"/>
    <dbReference type="GeneID" id="27901014"/>
    <dbReference type="eggNOG" id="ENOG502S7KH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107714_2_0_1"/>
    <dbReference type="OMA" id="KMRFYQV"/>
    <dbReference type="OrthoDB" id="3468019at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39401">
        <property type="entry name" value="SNOAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39401:SF1">
        <property type="entry name" value="SNOAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF17896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="146" mass="16444" checksum="169D2D771CFC936D" modified="2013-06-26" version="1">MTSQYIASVPSDGSIPSEIVEYFSKFYEISDSPANHEKYADMFTADGTIIMASNRVQGREAIIKLRHGMWEKVAKRSHVPKQLFGLGKGSEEEVMLYGTVDYTLKDGRGTTVDWSARAHFVKKEGEELKMDFYQVYLDTAAMANAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1QL38</accession>
    <name>N1QL38_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial pyruvate carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_146811</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mediates the uptake of pyruvate into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016766021.1">
        <property type="nucleotide sequence ID" value="XM_016903881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QL38"/>
    <dbReference type="STRING" id="692275.N1QL38"/>
    <dbReference type="GeneID" id="27901018"/>
    <dbReference type="eggNOG" id="KOG1589">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099502_0_0_1"/>
    <dbReference type="OMA" id="FRQNFYQ"/>
    <dbReference type="OrthoDB" id="869189at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006850">
        <property type="term" value="P:pyruvate import into mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005336">
        <property type="entry name" value="MPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14154">
        <property type="entry name" value="UPF0041 BRAIN PROTEIN 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03650">
        <property type="entry name" value="MPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF17900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="180" mass="19711" checksum="7429C39D65555BB4" modified="2013-06-26" version="1">MSARFGLRAVQNSFRQPVLRQQINTISQRRAQSTATNAAEATKAEATGFSKFFNSPVGPKTVHFWAPIMKWGLVLAGAADFARPAKDLSLSQNSALMATGLIWTRWCFVIRPQNMFLASVNFLLFCVGATQTTRVLLYQRSLEGNTATTLGEEIKKDAKEGLGDLEKAAKKVEGKIVSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1QL53</accession>
    <name>N1QL53_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_46791</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the nitroreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760037.1">
        <property type="nucleotide sequence ID" value="XM_016909014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QL53"/>
    <dbReference type="STRING" id="692275.N1QL53"/>
    <dbReference type="GeneID" id="27906151"/>
    <dbReference type="eggNOG" id="ENOG502RYI9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073125_0_1_1"/>
    <dbReference type="OMA" id="EMFENHT"/>
    <dbReference type="OrthoDB" id="2138173at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02140">
        <property type="entry name" value="Frm2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.109.10:FF:000001">
        <property type="entry name" value="Nitroreductase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="entry name" value="NADH Oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033877">
        <property type="entry name" value="Frm2/Hbn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43035">
        <property type="entry name" value="FATTY ACID REPRESSION MUTANT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43035:SF4">
        <property type="entry name" value="NITROREDUCTASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G03530)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="FMN-dependent nitroreductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="7">
        <location>
            <begin position="14"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF11916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="210" mass="23390" checksum="A12F39E87709CC11" modified="2013-06-26" version="1">MAAASTPAFFAAVETRISCYELSKESPIPDSRIREIVSTAVKHAPSSFNVQSARAVILLKAEHDTLWNIADRISQSAQPEMYNKMLGKMISGFSSAYGTVLWFEDQDALDGLAAKNPLFGDLVPGWGDTSSGMHQFIAWTALELEGLGCNLQHFNFIGEFEEEVKRQWGLPGTWRLKSQLVFGKPVNGLVRKRERSYLPMEDRVKIFGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1QL54</accession>
    <name>N1QL54_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_129309</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764469.1">
        <property type="nucleotide sequence ID" value="XM_016902278.1"/>
    </dbReference>
    <dbReference type="GeneID" id="27899415"/>
    <dbReference type="HOGENOM" id="CLU_243275_0_0_1"/>
    <dbReference type="OMA" id="EWSAKAN"/>
    <dbReference type="OrthoDB" id="3649822at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="314"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="450"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="684"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="716"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="884"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1381"/>
            <end position="1503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1607"/>
            <end position="1628"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="993"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1064"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1510"/>
            <end position="1544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="314"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="347"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="394"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="474"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="489"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="684"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="716"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="897"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="917"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1397"/>
            <end position="1410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1426"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1440"/>
            <end position="1449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1473"/>
            <end position="1482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1483"/>
            <end position="1494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1619"/>
            <end position="1628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF16348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1628" mass="182060" checksum="FA275D0A21B4CD1C" modified="2013-06-26" version="1">MAEESIKIAYHDATSGSGDFEQKDISFLDIGRMEAPAGGRGGCGGTGNGDEGYPPICCRKASQLKKRLKIIALSHSCEEQEKASKMAPKRKTPPGKDRGSGSSAKLALTDYMLAAQAVHKQAADTTRESSIRSYHPTWDPYTPPDLRRDLDPSQLRALRFYRYGLTNASTEYPGLVKPRVGSRRFPAGWEAYYPFARDRPNDAANATAQARAFVKARRHHKSLYSRSPETWKRASRGFESTWKKGRGKTVSRGKASDGLYYGQQNGKSKLNKFVENEVATFQKNKRIVDGEIYEDATSDYDSDEVYYEGADDSYWQNYNKPQSRPSDRRSTVSSEYVADEEATPRSVHFDEANEPRRHERLPPGPNGSTKKVPATSATTTTKSNTQPTVFPPHPHNKYNRHSKLSIPRSPPILSQAERAARRKWAARLSEDDYARAVADGMIIPLAPPTVTVKSSSRAKWETSNSSDQPRQNDVGDEAMDESGDVEMGDNNTNEENSDPNRNWSEGPSDSDSLEGLGRELAEVNIRQPAAPQVLRGLRLPRDWTPVWRNVDGEDRWLFYDQAAGVHRPNLPDPPLEMGSIDPNRVYDIFDRDMLPYPMPMPTPPWHLDCLSAEPHVARGYQAVRDDAGLWYYIQPNGDTLWHAPPGIPAFPDLDRTHFYAHDGLLHPVNESSRSIAPEHAPLLHENERFGAPDEGTREDPLGDEDDDLIVTEADLARLDAQERDADGRDATGEDEDLLPEHEEGYGGSDPTIMEEDEGEYSQPRSSLSLPSYEAYEPGGRLAEQGDQEDQGAGYQPHENLRRRSDSLRPTLGQPIVPPMAPMGGLPYARDKFIPPVPQMARFGEVPFPRNGFVPQIPDFGGLALPRSDLIAPTLDFDGLPLPRGGFVPPVPPPHVTGSATDGTRNSPSRNWRHEESFTISPGGTVSDPKITSSRPYFPNSPQYHPISVSSESDDYDAQQEAQDRTWETNQAPDGRSNLINNVGELGNEVARQLTEATRRILELEESARGHEQTIQELLDENDTGHDALLEAQDDALIAQNEAARLQTLLEARDGIANTTTQATSQQEQNLLQQANDKIKALQKELDDCHKHGEQLQAHMNQMEKELDDCHEDGNKFKDQAESAALKLHDCEAVNQRLHQQVADLENRLKVCEQDRNGEELLQNQITELKERLQSARGDGDLATQLEQCERARDDARKDLHDMYGEIPNLRLKLKDALAKSAEGSTECQEKLQAAEKRIAQLETELKDAEDTTAELLGAADEESRGGSNDCCKHCMDAKVQNEHLQDKIAELENDLEAAIQNQPADDDLRAAQALIAKLKKLARDKTDEALDLQKSLDECYRHGRRLQNKLNATEKAPAAPEKSSEKVVKLVPVISRSEGAKAKAALRAQDVTPQPPNHERRMVRGSDGKWTRSTTATSPVAAVEPVAEEMEEEEEDDQDTLMNDINSSDGDYDDEASSAGPSRARIFGIPGPDTDNNDSNNDNPHDFDLTEDQHFSSPPFHSPTDILKTLRRLREANRRLTRNLSNVRETNKRLMERIRTEEVRKHTIVESSAREYGERVQLRKDFDALVERNAVLQRCRDALLRQLRGETERLRSRGREGLSIFGGDGFLDQGEEGRRMKRKRSEVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1QLC4</accession>
    <name>N1QLC4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_138628</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016766111.1">
        <property type="nucleotide sequence ID" value="XM_016902883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QLC4"/>
    <dbReference type="STRING" id="692275.N1QLC4"/>
    <dbReference type="GeneID" id="27900020"/>
    <dbReference type="eggNOG" id="KOG1200">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_1"/>
    <dbReference type="OMA" id="NDWIQRT"/>
    <dbReference type="OrthoDB" id="1669814at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF45">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G09150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF17990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="264" mass="27515" checksum="96ED49E6C7A2419C" modified="2013-06-26" version="1">MAGKVFAITGGASGIGLAAAKLLVERGAKVSIADVSSKLNEAAVEIAQHAGLPQDECVLARSVDVRELSQIQAWLKATVETFGRLDGAVNSAGVFDYPKAATGQTAALWHQERGIDQWNHVIGVNLTGTANCCHVELEYMTSEAAKAENWGRSIVNMTSVAGFRARGGSPAYIAGKHGIIGLTKALAKQYGPVGVNINAVAPGAIDTPMNQNVGKEFVDAMVAGLPIPRRGTAEETAKMIVYLLSDDASYVTGATFTIDGGMTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1QLP2</accession>
    <name>N1QLP2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase M24 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_142424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760392.1">
        <property type="nucleotide sequence ID" value="XM_016902999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QLP2"/>
    <dbReference type="GeneID" id="27900136"/>
    <dbReference type="eggNOG" id="ENOG502QWQ6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072757_0_0_1"/>
    <dbReference type="OMA" id="KTHWHKR"/>
    <dbReference type="OrthoDB" id="2818246at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01066">
        <property type="entry name" value="APP_MetAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050659">
        <property type="entry name" value="Peptidase_M24B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46112">
        <property type="entry name" value="AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46112:SF2">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="1">
        <location>
            <begin position="15"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF12271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="251" mass="28688" checksum="60199F11EA6FBAD2" modified="2013-06-26" version="1">MSTETITTEQARAQSLREAENKAIELFDLISKDLIRPGITEKQLSDEIHQLGETTCHVRTHWHKRLVRSGPNTLSPFHDNPPTRTIQPGDILVIDLGPVFEEWEADFGRTYVLPEENSSSSNTTTTTTVIDATKQKLQLRDALEPMWWKIKRLYDRNPSMTGGELYNLALQTAAEDGWDWGATQIAGHIVGDFPHERIPRDKVTNYITEGNQQRMDEVDSKGNRRHWILEVHLRPKGAEFAGFFEQLLTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>N1QMA2</accession>
    <name>N1QMA2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Seleno_W_rel-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_130187</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="Zhong S."/>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
    <sequence length="188" mass="20620" checksum="A205C70CD95D7DD8" modified="2013-06-26" version="1">MNVTYLDLHSDYSPRYLSSSLPSDPCPSSAASFLFAAQVTIARWASFIAFALLGTYCSLDPIRGSAILLCYMTKQASFVVVSWYTSLVQVCSEANMWVLVALLDVQLQKQASFVMVSWYTSLVQVCSEANVWVLVALLAVHSPREDVQRQLGRIVDRIVGRSEKFKAVVGVLAKPGTTPRGAVTQHPA</sequence>
</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <text evidence="2">Belongs to the TspO/BZRP family.</text>
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        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="InterPro" id="IPR004307">
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    <dbReference type="PANTHER" id="PTHR10057">
        <property type="entry name" value="PERIPHERAL-TYPE BENZODIAZEPINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10057:SF0">
        <property type="entry name" value="TRANSLOCATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03073">
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="20"/>
            <end position="37"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF16599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="186" mass="20101" checksum="C51FED4A3ED5566E" modified="2013-06-26" version="1">MTTHIPSITLPAFLFEQPAAAVLLPIAAGTAIGFAISPSETRKFHAALRQPPLKPPGWIFGPVWTALYGAMGYASYRAWTIGTTSVNPRTVQLAKHGATLYTIQLALNLVWTPLFFGLKKPVAASADIIALTGTVGYLAYIWGQVDETSGWLLAPYLAWLGFANYLCHGAGYLNSWDFSTQGQKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>N1QMK1</accession>
    <name>N1QMK1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_76117</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764800.1">
        <property type="nucleotide sequence ID" value="XM_016910125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QMK1"/>
    <dbReference type="STRING" id="692275.N1QMK1"/>
    <dbReference type="GeneID" id="27907262"/>
    <dbReference type="eggNOG" id="KOG1051">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005070_4_0_1"/>
    <dbReference type="OMA" id="VSKMMQG"/>
    <dbReference type="OrthoDB" id="47330at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19499">
        <property type="entry name" value="RecA-like_ClpB_Hsp104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000017">
        <property type="entry name" value="ATP-dependent chaperone ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000120">
        <property type="entry name" value="ATP-dependent chaperone ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000025">
        <property type="entry name" value="ATP-dependent Clp protease subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000010">
        <property type="entry name" value="Chaperone clpB 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050130">
        <property type="entry name" value="ClpA_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638:SF176">
        <property type="entry name" value="HEAT SHOCK PROTEIN 78, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="115"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="516"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="Clp ATPase C-terminal" evidence="9">
        <location>
            <begin position="687"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="328"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF16679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="786" mass="86488" checksum="A9913AD9D36A3925" modified="2013-06-26" version="1">MLSTTGRSAARRIASVRYPLSRNALRAASCHTQRAIRLSPSAIPVAISQCRSYASGRPHPPGGTHRMNLGGEPEKSALEQYGIDLTAKAKDGKLDPVIGRDSEVHRTIQILSRRTKNNPVLIGSAGVGKTAILEGLAQRIVKGDVPESIQDKKVISLDLGSLIAGAKFRGDFEERLKAVLKEVQDAHGGVILFIDELHTLLGLGKAEGSIDASNLLKPALSRGELQCCGATTLNEYRQIEKDVALARRFQPILVGEPSVQDTVSILRGIKDRYEVHHGVRITDGALVAAAAYSNRYITDRFLPDKAIDLVDEAASALRLQQESKPDAIQELDRQIMTIQIELESLRKETDVASKERREQLEKTLTLKQDEVGALTEKWEAERAEIEGIKRTKEELERARIELDQAQREGNFAKASELRYAKIPELQKKLPEDQGGNSKTTAQDTLIHDSVTADDIASVVAKSTGIPVTKLMSGDIEKLIDMENVLRRSVRGQDEALVSVANAVRMQRAGLSGENRPIASFMFLGPTGVGKTELCKRMADFLFSSSNAVVRFDMSEFQEKHTVSRLIGSPAGYVGYEDAGQLTEAVRRKPYAVLLFDEFEKAHRDISTLLLQVLDEGFLTDAQGHKVDFRNTIIVLTSNLGAEALIADDSDGSEISPEVKKQVMDVVQASYPPEFINRLDEFIIFKRLSKEALRGIVDIRLKELQARLDDRRITLDVSDEVKDWLCDHGYDPRYGARPLNRLIAKEVGNSLADKIIRGAITSGDVATVTFQDGRNGLDILVPGVAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1QML2</accession>
    <name>N1QML2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Prolyl 4-hydroxylase alpha subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_35426</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765723.1">
        <property type="nucleotide sequence ID" value="XM_016908611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QML2"/>
    <dbReference type="STRING" id="692275.N1QML2"/>
    <dbReference type="GeneID" id="27905748"/>
    <dbReference type="eggNOG" id="KOG1591">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058132_0_4_1"/>
    <dbReference type="OMA" id="TVQCIEQ"/>
    <dbReference type="OrthoDB" id="420380at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF246">
        <property type="entry name" value="TRANSMEMBRANE PROLYL 4-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Prolyl 4-hydroxylase alpha subunit" evidence="8">
        <location>
            <begin position="96"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF17602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="331" mass="36692" checksum="0C98BEE672A34BF7" modified="2013-06-26" version="1">MANESRIYRTALEMAIISMVIYILVGAPGLSSSSSSPSSSSSSSSSSHDNSNSDSATSGLFSNSDKKVKIEHLVYPSKNLTCPKHDYTTHIFSTSPLVIYIEDFLSAEEVEHLIALSTNNWTPSTIFNAGLETTDPKIRKSEKASIPRSRLVQCIEQRALAFQGWPRDTFIERLWTQRYNVSGHYRLHYDWASSSKHSRRVSSFMVYLSSGEGLRGGGTRFPRLSGPSGKGNGGEMWCEFVECYDDDDDHHHQNEGKGQKEDGGGVTFKPRKGSAVFWMNFDEQGRGYKETIHAGMPVLEGQKIGLNIWTWYQAGHRAPESAGDEEVGSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>N1QMS8</accession>
    <name>N1QMS8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_146635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765798.1">
        <property type="nucleotide sequence ID" value="XM_016903780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QMS8"/>
    <dbReference type="GeneID" id="27900917"/>
    <dbReference type="eggNOG" id="ENOG502RGHA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1489888_0_0_1"/>
    <dbReference type="OrthoDB" id="5372011at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF17677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="181" mass="19820" checksum="28BA6E0A9022E0CD" modified="2013-06-26" version="1">MMAPHSPRTAATTNSSAIHNIINNNNNNNMGIRSTTTTTTTRGMTRSPTPESIESLRRRSEAADILESYEKLSWYAAARCETITQTRIHFKCILSGITAAQEQETVFWKEDFTPRPTKPNLQGSSSNSSRKAGKDRVVSDGSASGVVDRREREKCVVGENHSPKPHRKGKEKAVGGGSATM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>N1QN13</accession>
    <name>N1QN13_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_146088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765095.1">
        <property type="nucleotide sequence ID" value="XM_016903448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QN13"/>
    <dbReference type="STRING" id="692275.N1QN13"/>
    <dbReference type="GeneID" id="27900585"/>
    <dbReference type="eggNOG" id="ENOG502R8YY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1396277_0_0_1"/>
    <dbReference type="OMA" id="EWRWVTV"/>
    <dbReference type="OrthoDB" id="5272396at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF1">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="9"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF16974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="199" mass="23801" checksum="312B8C4E21417419" modified="2013-06-26" version="1">MSLARLLTLPLEIRELVWEHVLTEADQTLVTFRLDAFQREYYSYSTQPALARVSRQIRSESLPIWYERNRFIFHTEDAKAQDVRTWLRCNELHLEHIRHITLWVRYIPPANAHLQGALAVSIDRRKKHDPWQVDPNWTWITVLRRPPDLARDASYLIEKLRDMTSSISKDRAGVDDYYALIYRLRLLYIQEKTSARQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNK6</accession>
    <name>N1QNK6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_146410</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765490.1">
        <property type="nucleotide sequence ID" value="XM_016903637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNK6"/>
    <dbReference type="STRING" id="692275.N1QNK6"/>
    <dbReference type="GeneID" id="27900774"/>
    <dbReference type="eggNOG" id="KOG0682">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_33_0_1"/>
    <dbReference type="OMA" id="NVMMKNM"/>
    <dbReference type="OrthoDB" id="2363873at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140157">
        <property type="term" value="P:ammonium import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3430.10:FF:000003">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF10">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="10">
        <location>
            <begin position="31"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="451"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="451"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="501"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF17369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="514" mass="55558" checksum="5932EEF196BE58C2" modified="2013-06-26" version="1">MSVAKYNGTAPTGGDSLTEDLNIYYASGDIAWVITATALVLLMIPGVGFFYSGLARRKSALSLIWLSTMATAVVSFQWFFWGYSLAFSHTASSFIGDLSNFGLRDVLARPSVGSTRIPDLLYCVYQGMFASITVALATGAVSERGRLLPCVIFMFVWTTLVYDPIACWTWNPAGWSYKLGGLDFAGGTPVHISSGTAALAYSYILGKRKGHGTHALNYRPHNVTYIVIGTVFLWVGWFGFNAGSALGANLRAVMAALVTNLAACVGGVTWCLVDYRLEKKWSTVGFCSGVISGLVCVTPGSGFIPAWAAVVYGLTAGIGCNFATQLKYYLGADDALDIFAVHGIGGLLGNLLTGFFAADYIAHLDGVTKIDGGWINQHWVQLAIQLADSVTGMTYSFAMTCIILLTLSFLSRWLPSLKLRATPEEEEVGIDDTELGEFAYDYVEQLRDVKPEGMRDHDDLESIEGDGRSVNSISPSISRGPPSPLHSQPVETKQEYPLTHINREPRPGGHDHPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNS9</accession>
    <name>N1QNS9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="3 6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_146535</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3 6"/>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765670.1">
        <property type="nucleotide sequence ID" value="XM_016903714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNS9"/>
    <dbReference type="STRING" id="692275.N1QNS9"/>
    <dbReference type="GeneID" id="27900851"/>
    <dbReference type="eggNOG" id="KOG0549">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013615_8_1_1"/>
    <dbReference type="OMA" id="KPASCEI"/>
    <dbReference type="OrthoDB" id="1902587at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000006">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044609">
        <property type="entry name" value="FKBP2/11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779:SF7">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0697">Rotamase</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004111050" description="peptidylprolyl isomerase" evidence="7">
        <location>
            <begin position="20"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="8">
        <location>
            <begin position="41"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF17549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="140" mass="15024" checksum="4B60F26706BB9BC5" modified="2013-06-26" version="1">MKFASTLATLTVLAAGVTALDKPLDIKKTHTVECTTKTKVGDKVEMHYRGTLEKDGSEFDASYNRGTPLPFTLGKGQVIKGWDEGLLDMCVGDKRTLTIQPVYGYGDNAMGPIPAKSVLIFETELVSINGKGAETANAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNU3</accession>
    <name>N1QNU3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_78075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765740.1">
        <property type="nucleotide sequence ID" value="XM_016910182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNU3"/>
    <dbReference type="STRING" id="692275.N1QNU3"/>
    <dbReference type="GeneID" id="27907319"/>
    <dbReference type="eggNOG" id="KOG0907">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090389_14_0_1"/>
    <dbReference type="OMA" id="ANSMPTF"/>
    <dbReference type="OrthoDB" id="10263751at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050620">
        <property type="entry name" value="Thioredoxin_H-type-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10438">
        <property type="entry name" value="THIOREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10438:SF468">
        <property type="entry name" value="THIOREDOXIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF17619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="109" mass="12291" checksum="3758E1123F7649DE" modified="2013-06-26" version="1">MEELTDLAGYRKASNADGTAIFEATADWCPNCKAIAPFIEKLIKKYPDARFYSYNTDKALDISHELSAHQMPTFHVFKDGDLRDSITGPKAKEIEKAIVENYDGKMVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1QP01</accession>
    <name>N1QP01_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_58811</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016766030.1">
        <property type="nucleotide sequence ID" value="XM_016909475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QP01"/>
    <dbReference type="STRING" id="692275.N1QP01"/>
    <dbReference type="GeneID" id="27906612"/>
    <dbReference type="eggNOG" id="ENOG502S072">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049945_0_0_1"/>
    <dbReference type="OMA" id="HPRGWNT"/>
    <dbReference type="OrthoDB" id="411145at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004119">
        <property type="entry name" value="EcKL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012:SF30">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
        <property type="entry name" value="EcKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF17909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="418" mass="47037" checksum="A757961F857452DB" modified="2013-06-26" version="1">MPSGTCTLELTAVADDLLAGQGLKLLTCDVLQKLWQGYGYVCRISAMDKAQNKQSLILKYVKPPLTGQVESEGHIRKIISYEVEQHFYSDLAPQLPRDAVVAQCLASINNNGKVALLLEDLQRNFPVAGEKRGTLNKTQVHAAIKWLATFHGFWWDKTPDLRNHGFSRLPPLEEVLSQQDKGRSKRGVWLNGGYTYLATRMSEYTSLCHDGEQSEWSTSLCVPLLPRSNYSIAQLVARILSPANGILRDYETLIHGDVKSENLFTNKPGDAVAFFDFQYVGFGCGLSDVAKLFTCSVERDLLLFDEEEEEEEEGENEEERMGMAMGMGKGEERLLKHYQHILENVSGKKFSWEVLVMHWQTALIDWLRFQASWGFWGNTEWLEARARAILSNQDWLDWILDVTSTSTAAAAAATTTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M3AVM3</accession>
    <name>M3AVM3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Indoleamine 2,3-dioxygenase</fullName>
            <ecNumber evidence="5">1.13.11.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_151149</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Produces N-formyl-kynurenine through the oxidation of tryptophan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-tryptophan + O2 = N-formyl-L-kynurenine</text>
            <dbReference type="Rhea" id="RHEA:24536"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58629"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the indoleamine 2,3-dioxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.52" evidence="5"/>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758237.1">
        <property type="nucleotide sequence ID" value="XM_016906631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AVM3"/>
    <dbReference type="STRING" id="692275.M3AVM3"/>
    <dbReference type="GeneID" id="27903768"/>
    <dbReference type="eggNOG" id="ENOG502SIY6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033932_0_0_1"/>
    <dbReference type="OMA" id="TYELGPA"/>
    <dbReference type="OrthoDB" id="10262710at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033754">
        <property type="term" value="F:indoleamine 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.480:FF:000005">
        <property type="entry name" value="Indoleamine 2,3-dioxygenase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000898">
        <property type="entry name" value="Indolamine_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657:SF3">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01231">
        <property type="entry name" value="IDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="proximal binding residue" evidence="4">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600898-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF10116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="501" mass="56681" checksum="2CA30572684D4842" modified="2013-05-01" version="1">MSPYLSNTADQEKVRMSDTRAVFPHIHDDPAALPSSLDPFTITTQNGFLPLQTPQIELPSVFAPLQKLCDDMPIQKLDGTPGLLATCQLGPTIDEQKALPDLNHEIDNLIAADGEPDMAAVSAAFRDYSFLASAYLLEPCWEQWQKDGTYGLGRPVLPREIAGPLVKCAKMLDVPAFLAYAAGYALFNYRFADASIGASEYSNLRLIRAFENGLDASSSEAGFILTHVDMVKHTGPLVQGAVQLLDSVAADTGVTPVVDAFEHLLSTMRVIEDSMEGMWNQSKPKDYNRYRTFIFGITNQPFFPNGVIYDGYADNQPQYFRGESGANDAIIPLLDSLLQIPMPQNPLTEILKDFRGYRPKPHRDFLAYVRSRSEELAVKDYCLQDLQTKILYLRLLEHVRSFRWRHWLFAREYIMKRTPHPTATGGSPIVTWLPNQLFAVMELMRKVWESVSASEKAEQGKVVNEMMENVYESYEKLDKEVERWCQDRGWDRKKIDVHPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M3AWK9</accession>
    <name>M3AWK9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Profilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_150144</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the profilin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759251.1">
        <property type="nucleotide sequence ID" value="XM_016905984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AWK9"/>
    <dbReference type="STRING" id="692275.M3AWK9"/>
    <dbReference type="GeneID" id="27903121"/>
    <dbReference type="eggNOG" id="KOG1755">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120772_1_1_1"/>
    <dbReference type="OMA" id="QGQKFML"/>
    <dbReference type="OrthoDB" id="421374at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044396">
        <property type="term" value="P:actin cortical patch organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000755">
        <property type="term" value="P:cytogamy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00148">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.30:FF:000001">
        <property type="entry name" value="Profilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048278">
        <property type="entry name" value="PFN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005455">
        <property type="entry name" value="PFN_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036140">
        <property type="entry name" value="PFN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027310">
        <property type="entry name" value="Profilin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11604">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11604:SF0">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00235">
        <property type="entry name" value="Profilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00392">
        <property type="entry name" value="PROFILIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01640">
        <property type="entry name" value="PROFILINPLNT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00392">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55770">
        <property type="entry name" value="Profilin (actin-binding protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00414">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF11130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="132" mass="14112" checksum="69B5E2A7DCB28221" modified="2013-05-01" version="1">MSWQAYVDTSLVGTENLDKAAIFNSEGNSVWATSAGFTVSPQEMQAVVAAYKDEGTDGVKKVQSEGLHIAGERFVVIKADDRSIYGKKGREGVVLVKTTQAILVAHYPETVQPGAATNTVEQLGDYLIGVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M3AYT5</accession>
    <name>M3AYT5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_43982</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760833.1">
        <property type="nucleotide sequence ID" value="XM_016908911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AYT5"/>
    <dbReference type="STRING" id="692275.M3AYT5"/>
    <dbReference type="GeneID" id="27906048"/>
    <dbReference type="eggNOG" id="ENOG502QU5B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010147_1_0_1"/>
    <dbReference type="OMA" id="IYGIMES"/>
    <dbReference type="OrthoDB" id="1204at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070772">
        <property type="term" value="C:PAS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010513">
        <property type="term" value="P:positive regulation of phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903778">
        <property type="term" value="P:protein localization to vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000011">
        <property type="term" value="P:vacuole inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024260">
        <property type="entry name" value="Vac7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28258">
        <property type="entry name" value="VACUOLAR SEGREGATION PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28258:SF1">
        <property type="entry name" value="VACUOLAR SEGREGATION PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12751">
        <property type="entry name" value="Vac7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="552"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF12712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="572" mass="64185" checksum="98923811402BCE31" modified="2013-05-01" version="1">MTVETETVQSIPQSQLAPANDRSNQRNENSGTVKLKPSNETIRPKKERKKAAPKTRSVNQGTATSKADLFEARVANAVDEANTSDSDETFVYESNPPEQPRRQRHHSRTPSVTSSHSMADQQRGLIRGYNDPFDGPRVGGKRSMKFSTNPTNPYGLDSPDSNNGTVRMHTPKHIGRFGRSGNQSSSHDQDSPFTQASKLRNNHLVQDRSRPTSPRSPQNMQFRPSSFFSSNKKQEQPYDFDAGQTADDERTPLMGHGTVRTPRRSHYHPHRFSNSMTHSMENYYTEEEEPRGCFGVRKWGGCLLTTLVLILVVISALGFVFASNRPLMDVKVHKIHNVLASETELMLDLLVGAVNPNTLGISVSDLDVSIFARSKHVTKPNRTEPEHPVNRRQMRRGRRATVSDDIPTSPIQDPDGHWHAPGDKDPKDDPNIDARTLKLGEVFHFDQALVFEASPLKQHEHISSGQLRLTKPGNRTESRGSAHWEEIILYPFELIVRGTIKYQLPISSRLQSVAIEAKTIVHPEEDLDKHGNMKTVPVNHSEDWQWIEKPGINYDDAEDESETGAGAVEEMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M3AZ09</accession>
    <name>M3AZ09_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_149339</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760903.1">
        <property type="nucleotide sequence ID" value="XM_016905498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AZ09"/>
    <dbReference type="STRING" id="692275.M3AZ09"/>
    <dbReference type="GeneID" id="27902635"/>
    <dbReference type="eggNOG" id="KOG4205">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_0_0_1"/>
    <dbReference type="OMA" id="AMPNMMN"/>
    <dbReference type="OrthoDB" id="1875751at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12577">
        <property type="entry name" value="RRM1_Hrp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000025">
        <property type="entry name" value="RNA-binding protein Musashi homolog 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034156">
        <property type="entry name" value="Hrp1_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032:SF6">
        <property type="entry name" value="RNA-BINDING (RRM_RBD_RNP MOTIFS) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032">
        <property type="entry name" value="RNA-BINDING PROTEIN MUSASHI HOMOLOG RBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="102"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="186"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="261"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="382"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="445"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="51"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="272"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="390"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="408"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="513"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF12782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="536" mass="56835" checksum="FAAC26E6C3316636" modified="2013-05-01" version="1">MAEPGMDDEDLFADLYDGDDTANDTPAPVVKPEVDPQDAADAAAAAADDFLSQQQAEPVTETNESNGFKQEQSYDQDMGGQQNEFREPEPDNRPLIGSKEDGKMFIGGLNWETTDQSLKDYFSQFGEVIECTVMRDGATGRSRGFGFLTFRDPKTVNTVMVKEHSLDGKLIDPKRAIPRDEQERTAKIFVGGVSQDATEQDFEAFFQKFGRVLDATLMMDKDTGRPRGFGFVTFDNEMAVERTLEGPLAILGKPIEVKRAQPRGKMDEENAGGRGGFGGGRGGRGGFGGGGRGDSGFGNNNNNQMAAAPAQDGNANTMTPAMMAQYWQRMQQYFAQMQAMQQGGGMGGMMGGMNPMMMQQMQAMRAGGQMNPQMMQQMMAMQGGGGGMQGSQSPMNGGAGRGAPNNGNGNGGAGGGNQSGFSAQEQLMFEQQKYERQTLARMQGQNFGGQNTWDGMYDDVPPPDGMGPGPQRGGFGGGRGRGGRQGSAQPPNPNAPVGAPTGPKNHGRPGANYRGGGRGGRGGGGGGYHPYARGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M3B185</accession>
    <name>M3B185_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquinone biosynthesis O-methyltransferase, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">3-demethylubiquinol 3-O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.64</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">3-demethylubiquinone 3-O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Polyprenyldihydroxybenzoate methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.114</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">COQ3</name>
        <name evidence="7" type="ORF">SEPMUDRAFT_64537</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">O-methyltransferase required for two non-consecutive steps during ubiquinone biosynthesis. Catalyzes the 2 O-methylation of 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid into 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid. Also catalyzes the last step of ubiquinone biosynthesis by mediating methylation of 3-demethylubiquinone into ubiquinone. Also able to mediate the methylation of 3-demethylubiquinol into ubiquinol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-methionine = a 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44452"/>
            <dbReference type="Rhea" id="RHEA-COMP:10930"/>
            <dbReference type="Rhea" id="RHEA-COMP:10931"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64694"/>
            <dbReference type="ChEBI" id="CHEBI:84443"/>
            <dbReference type="EC" id="2.1.1.114"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3-demethylubiquinol + S-adenosyl-L-methionine = a ubiquinol + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="Rhea" id="RHEA-COMP:10914"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:84422"/>
            <dbReference type="EC" id="2.1.1.64"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3-demethylubiquinone + S-adenosyl-L-methionine = a ubiquinone + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:81215"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:19654"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:231825"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.64" evidence="5"/>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EC" id="2.1.1.114" evidence="5"/>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761653.1">
        <property type="nucleotide sequence ID" value="XM_016909682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B185"/>
    <dbReference type="STRING" id="692275.M3B185"/>
    <dbReference type="GeneID" id="27906819"/>
    <dbReference type="eggNOG" id="KOG1270">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042432_3_1_1"/>
    <dbReference type="OMA" id="LASRWWD"/>
    <dbReference type="OrthoDB" id="3265906at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061542">
        <property type="term" value="F:3-demethylubiquinol 3-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120537">
        <property type="term" value="F:3-demethylubiquinone 3-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010420">
        <property type="term" value="F:polyprenyldihydroxybenzoate methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00472">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010233">
        <property type="entry name" value="UbiG_MeTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01983">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464:SF19">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS O-METHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0830">Ubiquinone</keyword>
    <keyword evidence="3 5" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF13532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="319" mass="34747" checksum="D9CA596A74A36502" modified="2013-05-01" version="1">MGFRSYATYNTNASATPPSPPPSSSSSSSSSSSSSVNATEISHFNTLASSWWDPHGSSRLLHLMNPLRHQFIQKKCLIHTHDDLSSHGTATETNTQRKTKKLKFLDIGCGGGIFAESAARLAMAESVVGIDPTPECIRVAKAHARQDPLLLQPGKLVYKNVAIEELALPSFSSTSASNAEGKDGEEAGFDVISLFEVIEHIQQPGPFLENVLKHLKPGGWLVGSTIARTGTSWFTTKFVAEEVLKMVPRGTHEWSQYINPGEMREWARSRPELDVAVGSPGWQQMGVVYVPGLGWKVVDGSEDWGNYFFGMRKVGSADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M3B2L1</accession>
    <name>M3B2L1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CST complex subunit Ten1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_61946</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762123.1">
        <property type="nucleotide sequence ID" value="XM_016909581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B2L1"/>
    <dbReference type="GeneID" id="27906718"/>
    <dbReference type="eggNOG" id="ENOG502SESG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102601_1_0_1"/>
    <dbReference type="OMA" id="GCVTHYT"/>
    <dbReference type="OrthoDB" id="5275361at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990879">
        <property type="term" value="C:CST complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043047">
        <property type="term" value="F:single-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016233">
        <property type="term" value="P:telomere capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024222">
        <property type="entry name" value="Ten1_fungal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12658">
        <property type="entry name" value="Ten1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF14002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="162" mass="18045" checksum="FF98145B536BAD98" modified="2013-05-01" version="1">MATNHDPTCRRPEPARLLLLDQVRHQEPGTKIRVLGCVHAYHIASATLVLKLEYPSKSSNSRNPKTLPVPTVLANIDNVLEAVNHDLLQVGSWLNVVGYVRKPQNLSGRRRRRDVIPLMDVLLIWSAGAIKLDDYQSAVRSYQETLLPGTTTTSEEKGTETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M3B2V0</accession>
    <name>M3B2V0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_39688</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762233.1">
        <property type="nucleotide sequence ID" value="XM_016908758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B2V0"/>
    <dbReference type="GeneID" id="27905895"/>
    <dbReference type="eggNOG" id="ENOG502S6IQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040050_0_0_1"/>
    <dbReference type="OMA" id="FATYEEP"/>
    <dbReference type="OrthoDB" id="5377213at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF14112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="374" mass="40862" checksum="D386F2C3D2948074" modified="2013-05-01" version="1">MASAKEDQGTIDLDKSIAENERLAGLGIHHFASRSAADVTFGHPNRRQTHARTTSIGSQASNGSSTFRTGGQPFIHPATKVPRPYTPPGASYASSVNDDEADESNDVVEDEFRPGPGFRSKRSMSITSSTNPTPLSQSHTASDLGLIPKLTNVSQSNLSIMSRASSTSNQKSRPRRGTDHSDLATSPQTMGRPSIDKALSLVSGRRSDPDTQSRDEAIRNARRKFEEKEAKKDNREQKRRESEEAKKEAARQRKQSNVSERAGIKTAALGHTSSEDKIPGQKRKGSTATVLSGAPQASQEDTEVPGTLYARSYEDYRPAHAATLPRHGDLPGESEKTGRIQYTMTAQEQPNGSWMRFSTWVQTRLLSCGRGRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M3B5X4</accession>
    <name>M3B5X4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Ferric_reduct-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_147148</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763338.1">
        <property type="nucleotide sequence ID" value="XM_016904114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B5X4"/>
    <dbReference type="STRING" id="692275.M3B5X4"/>
    <dbReference type="GeneID" id="27901251"/>
    <dbReference type="eggNOG" id="KOG0039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010365_3_1_1"/>
    <dbReference type="OMA" id="WMDEVLR"/>
    <dbReference type="OrthoDB" id="4494341at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF12">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="80"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="285"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="11">
        <location>
            <begin position="369"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF15217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="713" mass="80715" checksum="675A449DD87831BE" modified="2013-05-01" version="1">MHPLHHLHHLATTIHGRRALGIPSASDDRHIMATRDPDPLPDAIPFAQPGSGDVKDFGITLDLSAAAAPFSHGLNGVNQYLNYLLANVLVISFMALLAGTLLYRWVQMGHKHMRHLFTMGRERDQRYFQYNHTKAWPWIKRYVLYAPFWKVRHNREFRLWRSQVTMGTLPSRFHSFLLFVYLVSNAGYCAALDYSQTRPSVIAEFRGRTGVLAALNLIPTILFALRNNPAIYFLRVPYDTFNLLHRWTARMMVLESILHTIAWAVNAYDAGGGPQIGLSLRTSTSYMWGMVATAVLTYMVLASSGPIRHQFYEFFINSHRVLAILAIVGIYIHLDKANLPMLPYVQLSLAFWSAELFARFYRIAYHNWTRKRGLTKVTVEWLPAEACRVTYQISRPWKWRPGAHVHAYLPSIALLGSHPFSVAWAENRPQHTPSMEFEMEKLPPMTTGVFSDQVRHSMMARNSMMARHSMMPRDSMVGGLPSHTRNLTLTEMASAAEVTHKAADGNITLPGDDKVTTISLVIRARDGMTRSLYDKLVNNDRQPITTWGLIEGPYGGHESLSSYGTVILFAGGIGITHCIGYIHHLMAQYAAGTCSTRKILLVWSVPNTECLEWVRIWMDRILRMEHRRDVLKIQLFVTKPRHRGEVVSSTGSVQMFPGRCRPSAVIEKELPERIGSVAVTVCGPGALADDVRAACRKHVEHASLDFVEEAFTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M3B6L2</accession>
    <name>M3B6L2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enhancer of mRNA-decapping protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_131111</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EDC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763538.1">
        <property type="nucleotide sequence ID" value="XM_016902395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B6L2"/>
    <dbReference type="STRING" id="692275.M3B6L2"/>
    <dbReference type="GeneID" id="27899532"/>
    <dbReference type="eggNOG" id="KOG2585">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024328_0_0_1"/>
    <dbReference type="OMA" id="AWRKYGT"/>
    <dbReference type="OrthoDB" id="10030313at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031087">
        <property type="term" value="P:deadenylation-independent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="entry name" value="YjeF N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025762">
        <property type="entry name" value="DFDF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019050">
        <property type="entry name" value="FDF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13612">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13612:SF0">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09532">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01199">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="YjeF N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51512">
        <property type="entry name" value="DFDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DFDF" evidence="7">
        <location>
            <begin position="344"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="YjeF N-terminal" evidence="6">
        <location>
            <begin position="554"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="225"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="381"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="590"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="261"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="310"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="432"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="446"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="498"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="599"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF15417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="836" mass="89441" checksum="122B4AFCC25870F1" modified="2013-05-01" version="1">MAHDSPIGKLVWMRLKQPRHVLYGQIEDIDPPNSITFRDVVFPGSSTYLAQWTVQSTAIDDTAIVNSFPPEVLEVLRSQPQPHQQPATIPPQMSHAHPPPPAFQYPQQLPNGHHPAPSMPHSPFAGSVPVPVNRIAELPARITASPAPQAAVGQQSVPAFVDPAILSYDTSSPVQRRRTSKPAGLETPIKSMLTRAAANLPSPSSPFIGDITKANVAQKMAAAKQAGAAQQQPPVPVASKPSVEAALGDDVQNPVVENGGKKKVRRGQKVKKQPPDAGQDPPPVMNAEVSRNGNDMNGQVKRGKGWRSTPLLQPSPSAGPSLDQANTKKSRRKHKGELEQEFAQGDTTDIQDMGDFDFDAGLKKFDKKQVFDEIRQGDTTADEDRLVSHNKARPGTYGGKNLHPTENVLSPKLETKYNSNETDNTSDADTELGLGLANGSSSSKHSVSRKVFPKTRPSRQNSAQVDSLPRPPPHLLAASLSSDRVRDRSTTSRVSRGKQATSLATSSPKPDRANSPSAISVTKTAIQGSAKNQDPHFAISSHMSTCPTLLPKALENLEAATVSTFSLSQEAIAENAARSVAETALHLSEAHKGLRRPSRTNTMRGSMTGSMTLNSPPESSTIVILAGNHDIGARALAAARHLLGRNVKIIAVESTFESAATQHPHVHAQRAILRKLAQAGAKVKRGAWHKCQKAIKNLTGPPVVIIDALLAGATFESLLEPNADFSALVQQETREMIDWANRSRAPVLSVGCPSGVSGVDGVSTIVEGEPLAVRPDRVLALGAPMSGLLKATEAGERWNISLADIGINIGLKVEDQVVFGESWSVNLKYVDEEAMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M3B6N4</accession>
    <name>M3B6N4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_147333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763568.1">
        <property type="nucleotide sequence ID" value="XM_016904233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B6N4"/>
    <dbReference type="STRING" id="692275.M3B6N4"/>
    <dbReference type="GeneID" id="27901370"/>
    <dbReference type="eggNOG" id="ENOG502TC4Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051206_0_0_1"/>
    <dbReference type="OMA" id="IALHEHM"/>
    <dbReference type="OrthoDB" id="4159781at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF15447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="464" mass="50977" checksum="BBAB492BAC4D1809" modified="2013-05-01" version="1">MSDGNNAAAAKRPVKKKQIDFIVTTSDPNSASNAANKKRVRSVAALKSWPERRKKIFDQLESSGSSGQGAFLLDDQPAAPSRRKPKSPPQPFRIVQQQETPPSAGSAPKRAKAHGPFRATPASSTAAYALNPDAQTFVPTTSSTVGDFSAQLDHAIEQKSIGSSIELYRKFSANLPLSPDVHHVQTTGATCQCSTCQPQCGTAVVPPRRKRMADGSEKPMSTFTGEMALITPPTSPTAGASSHQMDPFNNYPVEYKPWYDKILYHMMTVYAPRGWPALKITEQEGVKWEWFMTQTALAEPALFYVRLLFGSGDMIRLGALGSEIMYWLRAEAIKAINTALGDSKRNCSDGLILAVGRIALHEHMYGDKFASSHIHRPAQRRMIDMRGGMKKLGFPDLVKRLMRWSDRIMAVGSGTDRLLEDDDAIPNFSLKQSVGAIEGWAPQEMPGVRSKIRISDLVNDEDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M3B6W4</accession>
    <name>M3B6W4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Delta-12 desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_80397</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763678.1">
        <property type="nucleotide sequence ID" value="XM_016910243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B6W4"/>
    <dbReference type="STRING" id="692275.M3B6W4"/>
    <dbReference type="GeneID" id="27907380"/>
    <dbReference type="eggNOG" id="ENOG502QQNB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033094_0_0_1"/>
    <dbReference type="OMA" id="FYLFHNY"/>
    <dbReference type="OrthoDB" id="1461976at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03507">
        <property type="entry name" value="Delta12-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021863">
        <property type="entry name" value="FAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32100">
        <property type="entry name" value="OMEGA-6 FATTY ACID DESATURASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11960">
        <property type="entry name" value="DUF3474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fatty acid desaturase N-terminal" evidence="8">
        <location>
            <begin position="76"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="7">
        <location>
            <begin position="136"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF15557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="490" mass="54528" checksum="490CE5BDB01CE5CA" modified="2013-05-01" version="1">MSTTALPQQQSAVRRTITMDSVPSTGSNSTAGTPDDSPTASASSTSLSSLGSVEDFQQKSAPQKLIDTYGNEFELPDYTINDIRNAIPKHCYERSAVRGLSYVARDFALLATTFYIFNKFCTPEYVPSYALRAGLWAFYTFAQGCFGTGVWVLAHECGHQSFSPSKVLNDTVGWVCHSALLVPYFSWKISHGKHHKATGNMERDMVFLPRTREEHATRMGACLHEMHELLEETPIYTASMLLGQQLAGWPLYLFKNVTGHNNHEKQPEGKGVGKKNGDGSVNHFLPSSPLYERKDEHLILLSDLGLAITVSILTLVGRTYGFQNLLVWYILPYLWVNHWLVAITYLQHTDPSLPHYTGDAWNFTRGAAATIDREFGFIGRSLMHGIVETHVLHHYVSTIPFYHADEATEAIKPIMGRHYRANVEGGSLGFVQSMWSSARWCQWVEPNEGATGEHSKVLFFRNRNGLGVPPAKMAAPGAKKSSMMVGDDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M3B773</accession>
    <name>M3B773_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4440 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_38865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763823.1">
        <property type="nucleotide sequence ID" value="XM_016908721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B773"/>
    <dbReference type="GeneID" id="27905858"/>
    <dbReference type="eggNOG" id="ENOG502SS9Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120072_0_0_1"/>
    <dbReference type="OMA" id="CSSAWVL"/>
    <dbReference type="OrthoDB" id="2865667at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027843">
        <property type="entry name" value="DUF4440"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14534">
        <property type="entry name" value="DUF4440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4440" evidence="1">
        <location>
            <begin position="7"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF15702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="133" mass="14896" checksum="AE4D1B02E3D56D83" modified="2013-05-01" version="1">MSLHDRILDLEEQTWRALQTDGSALIPYLTSDAIMQFPLGLKVTANSRPSVQDILHSSAFVPWRTFRLKNVDVTPVGADGAVISYRAIATRASVDPKDERDAEFDALCSSVWRKDGASFYMCFHQQTMTEEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2024-01-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M3BNZ9</accession>
    <name>M3BNZ9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF659 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_55188</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456282">
        <property type="protein sequence ID" value="EMF07903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756024.1">
        <property type="nucleotide sequence ID" value="XM_016909343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BNZ9"/>
    <dbReference type="STRING" id="692275.M3BNZ9"/>
    <dbReference type="GeneID" id="27906480"/>
    <dbReference type="HOGENOM" id="CLU_3074522_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF07903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="53" mass="6179" checksum="C22A29CEECD374F6" modified="2013-05-01" version="1" fragment="single">EGMLGFPYITSRYTSDHLAEILFEILQEFEIERRLTAITYDNASNNKTLHNAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M3BV63</accession>
    <name>M3BV63_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_150203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759335.1">
        <property type="nucleotide sequence ID" value="XM_016906017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BV63"/>
    <dbReference type="GeneID" id="27903154"/>
    <dbReference type="eggNOG" id="ENOG502TBBA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1628103_0_0_1"/>
    <dbReference type="OrthoDB" id="3642232at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF11214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="163" mass="18689" checksum="777C160E41E9CF15" modified="2013-05-01" version="1">MTFSLFSSAKRNNSDFDLESALPHHIHLLKSRSRSTITPTMALLYSPSTSGHWHAAPDDESEHAYETVNDFLGVKVSDRQHHEQQPRPYSSQTVTTVALQGKTYRVPDPSNKQFYRELTFLSDEEMIMKYRLVPYTKGDERKRASKRFSISSRPTHGASLRAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M3BW21</accession>
    <name>M3BW21_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_150428</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759640.1">
        <property type="nucleotide sequence ID" value="XM_016906169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BW21"/>
    <dbReference type="STRING" id="692275.M3BW21"/>
    <dbReference type="GeneID" id="27903306"/>
    <dbReference type="eggNOG" id="KOG0106">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_34_5_1"/>
    <dbReference type="OMA" id="PREPAYP"/>
    <dbReference type="OrthoDB" id="1099063at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12339">
        <property type="entry name" value="RRM2_SRSF1_4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF51">
        <property type="entry name" value="SERINE-ARGININE PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="35"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="130"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="206"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="340"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF11519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="359" mass="40130" checksum="4C1172361C9B47F3" modified="2013-05-01" version="1">MFCAPFSALRVGLEPELALYWPSHHPASQPTESPDLATLTGIRDTATKADVENHFNTHGTGEITEIKLMNGFGFIEYKDAMDARDVVPAFHGSEFMGERLVVQFARGSTRPREGFEHQPRMAPRPRRTVHRMTITGLPFETSWQDLKDFARQSGLDVVYSEVNRERDPAGTGKGFVEYETAADLASAVEKLDNSEFKGATVRCISDPQADVPRPRERFRSRSPGFRGGGRGGYGPPPDDYYDRRGPPRGYSPRRDDYRRRTPPPRDYYGGDPRDDRYGPPRGGRPPVDDYYGPPRGGRPPVDDYPPPPRRGGYEPEPYANGHGREPYAGRPRSPPRDGGRGYGGGSGGGREPYAERPYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M3BX59</accession>
    <name>M3BX59_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WD40 repeat-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_65918</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification.</text>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760772.1">
        <property type="nucleotide sequence ID" value="XM_016909733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BX59"/>
    <dbReference type="STRING" id="692275.M3BX59"/>
    <dbReference type="GeneID" id="27906870"/>
    <dbReference type="eggNOG" id="KOG0280">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036100_1_0_1"/>
    <dbReference type="OMA" id="LDMKWLP"/>
    <dbReference type="OrthoDB" id="1930760at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061685">
        <property type="term" value="F:diphthine methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052415">
        <property type="entry name" value="Diphthine_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042:SF1">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="396"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="405"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF12651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="440" mass="48688" checksum="A0CCBD3C1F164743" modified="2013-05-01" version="1">MATLSSIRSLTLDLPPSCIQFCPGKPHIFVVGTYFLHAPPTSEVEASSSPNEKIEARQAAQKRTGSLVLYEMSPENIITEIQSLATDFAILDIQWTPHSELVGGDLLAVATSTGILAFYRLQQQQEQPKLVLSHVQHITDDDTTLVLSLTWHPVRAGVLGLTLSDGRVCVCTSTSTSMGTGSGSGSGSTEEDDTAAGLWSQDAAVSLQDVHEHELEAWMMTFTLESLNVLSGGDDMVLQCSHQHIQKTNKNKTNLLWQNRKLHHAGITAILPLSETLIITGSYDDHIRLLQLPKIPGDTRPKLLAELNLGGGVWRLKLLTIRGGASSSSSSSSSQRDDDSANAAENKSSFILLCSCMHAGTRIVQVIHEEKKKKKEDNDEEEWKFHVLAKFEEHESMNYGSDVQPDLKEKKKKEKEEKERKKIVSTSFYDRRLCLWTVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M3C0E7</accession>
    <name>M3C0E7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-L-fucosidase</fullName>
            <ecNumber evidence="3">3.2.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_84996</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 29 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.51" evidence="3"/>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761922.1">
        <property type="nucleotide sequence ID" value="XM_016910371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C0E7"/>
    <dbReference type="GeneID" id="27907508"/>
    <dbReference type="eggNOG" id="KOG3340">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002934_4_1_1"/>
    <dbReference type="OMA" id="NEWINDQ"/>
    <dbReference type="OrthoDB" id="6039950at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016139">
        <property type="term" value="P:glycoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016286">
        <property type="entry name" value="FUC_metazoa-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000933">
        <property type="entry name" value="Glyco_hydro_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057739">
        <property type="entry name" value="Glyco_hydro_29_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030:SF37">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01120">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00741">
        <property type="entry name" value="GLHYDRLASE29"/>
    </dbReference>
    <dbReference type="SMART" id="SM00812">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004031649" description="alpha-L-fucosidase" evidence="7">
        <location>
            <begin position="21"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 29 N-terminal" evidence="8">
        <location>
            <begin position="319"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF13801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="792" mass="87884" checksum="C1156D7509BBDA2B" modified="2013-05-01" version="1">MKQSLVAAVVHLPLLALASAGVETPQGHSVPVSLVEHFNNKAFGSYPGEAALNILNQSYPADPVAVDGFYTSRSTGISYLFPGYNPDPGAADNVICDGQVIDIDPSEDYISVSFLAVSDVRSTTVSGNVTLLFTDNTTSQYELRAHAFWWFLAIRRGEITYPYYFTHNDTNHNASEIYERHAFVETGKSLRGLVLPETTNTTTGRLHVFAISLWKAGGSGIEVQAMRPTQKFDSQGSQIVEVIINHRGPSCVSNIEVSLDASGRGMSGSTVVRRFCPGEQKIVNLAVHGQSQGDVTITLSVPGSQPVCRVFPNIKISLEDWEAKSTSLIQHETPEWYNGAKFGIFIHWGPYAVPSWGNSTPTECYAEWFWWYSTRVGDHAAADRCGFNAYRLRTYGPDLLYDDFFDNYTASKFDPKSWVDLFAAAAAQYFVFTTKHHDGFANFDAGHTTNRSAIHYGPRRDLLGLLFEAAEQYQPHLKRGTYYSIPEWFNPDWGKYGFTQYGDRVTSTSHPGIIARNPYTGQTEPYTGRVPIGDYITDLLVPQMEILAYQYKSDIMWCDAGASNGTDVFAASWFNWAKAQARQVTINDRCGSPWAADFDTPEYQTFSTAQQRKWESNRGMDPFSYGYNRATAPESYANASSIVMQLVDMVSKGGNLLLNIGPKADGSIDETMVNNLLEAGAWIHAHGEAIFNTTYWSVTPEEGKLRFTQTNDAFYIICLSTPVFGSQLVVKSPIPVQSGDTVTAITMSGEIGVKWGWLRDDAAGENHFFIEVPEATVIPDMFCWVFKVQYGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M3C213</accession>
    <name>M3C213_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulfate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_62596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762457.1">
        <property type="nucleotide sequence ID" value="XM_016909608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C213"/>
    <dbReference type="STRING" id="692275.M3C213"/>
    <dbReference type="GeneID" id="27906745"/>
    <dbReference type="eggNOG" id="ENOG502QRGR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032158_1_1_1"/>
    <dbReference type="OMA" id="GSMPVCH"/>
    <dbReference type="OrthoDB" id="5402974at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015098">
        <property type="term" value="F:molybdate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031563">
        <property type="entry name" value="MOT1/MOT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31970:SF9">
        <property type="entry name" value="MOLYBDATE TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16983">
        <property type="entry name" value="MFS_MOT1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF14336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="447" mass="47204" checksum="CEE4DBA2E341B5AE" modified="2013-05-01" version="1">MTWRADLRLINHHNVQTLRTSPLAELSGALGDLGTLLPLMIAMAIKGSIDLGSTLVFSGLANILTGVFFGIPLPVQPMKAIAAVAISQGFSKEETAAAGLTMGVAVFLLSATGLLKWLNRVVPVSVVKGIQVGAGLSLVISAGTSLVKPLGWVSPAWDNRVWAIAAFLFLLLATLVPRIPYALVVFLIGLIIAAAVPGVDHERSFSAGIWHPSPFVPSGEAWKTGAIDAAVPQLPLTTLNSILAVASLAASLFPTFPPTPSTTSIGFSVAFANLIGCWFGAMPVCHGSGGLAGQYRFGARSGSSIIILGSIKLVLGLFVGDAIVPLLQRFPNSLLGIMVLAAGVELSKVGQSVGESKDLWEQADEDNIDQMPPRKSRQATEQESNDRWVVMLITVAGCLAFKNDAVGFLAGLVWHWGLQCPQLVEHVWPRRSSVRLSNAEQEDGLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M3C308</accession>
    <name>M3C308_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_148304</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I NDUFA12 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762782.1">
        <property type="nucleotide sequence ID" value="XM_016904838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C308"/>
    <dbReference type="STRING" id="692275.M3C308"/>
    <dbReference type="GeneID" id="27901975"/>
    <dbReference type="eggNOG" id="ENOG502S4P5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067876_0_0_1"/>
    <dbReference type="OMA" id="WQPKAWD"/>
    <dbReference type="OrthoDB" id="10255576at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052618">
        <property type="entry name" value="ComplexI_NDUFA12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007763">
        <property type="entry name" value="NDUFA12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32470">
        <property type="entry name" value="ADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32470:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05071">
        <property type="entry name" value="NDUFA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="101"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF14661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="213" mass="24647" checksum="EFB4F5616E9470E2" modified="2013-05-01" version="1">MPQPGVLARAWFKWKTLRLPWRKTFLVGFDLSGNTFWEFKDALNTNRMRRIVKYNNKTPHYSDVKVTPQWHQWLRNTRDEPPTIQEQQHDISRQAMMKRLAAEADERWNSKPSFLDGPSRNQPQPAIGVKDPGGYMEQTEPEQQQGVRSAVDEPEKVEAASQGKQEGLDEGRFKGTKTKDRKPNPWDQARPKGNAGENWQPAGWTPMPAQRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M3C337</accession>
    <name>M3C337_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding domain of Mlu1-box binding protein MBP1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_40646</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762812.1">
        <property type="nucleotide sequence ID" value="XM_016908793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C337"/>
    <dbReference type="STRING" id="692275.M3C337"/>
    <dbReference type="GeneID" id="27905930"/>
    <dbReference type="eggNOG" id="ENOG502S1IW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1010316_0_0_1"/>
    <dbReference type="OMA" id="FECTEDS"/>
    <dbReference type="OrthoDB" id="5562739at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030907">
        <property type="term" value="C:MBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033309">
        <property type="term" value="C:SBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051642">
        <property type="entry name" value="SWI6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828">
        <property type="entry name" value="ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR XBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="2">
        <location>
            <begin position="130"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF14691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="276" mass="31221" checksum="60E2E736A71AAE4B" modified="2013-05-01" version="1" fragment="single">MLKIHSLLNPTSDYRYPGHHTNTPPPTPAYTTHGYSQAGTPQPETPNTPSPSKRQKLIKDAAVFLRGGAIKGNINYPPFECTEDSLCLDSYQRQELAREHERFQIFPCGRGDEGLISDYVRHIPYSSEKKSFLNKTGRDAFDVFQYTFNVPWDPTNRTHVVMWDYQIGLVRITPFFKACDYSKTIPAKALNTNPGLKELAHSITGGALAAQGYWMPYACARAVCLTFCYPIRWALTPIFGASFIKECLRRDDPGFGRFKIDPEVVRCASLEAEGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M3C3A3</accession>
    <name>M3C3A3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_148382</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762887.1">
        <property type="nucleotide sequence ID" value="XM_016904888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C3A3"/>
    <dbReference type="GeneID" id="27902025"/>
    <dbReference type="HOGENOM" id="CLU_2251745_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF14766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="104" mass="11984" checksum="D28066FDBB9E3FF7" modified="2013-05-01" version="1">MPPWRLQHNLLESDRSLLPQNNLPRQRTLSPLHRAQHLYEAETVFTTTMDYNLQLYVSLTGRDMTDHYGSLDVLINAAGNLQPWGTQIGRDMTDHYGSLDVPQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M3C3V9</accession>
    <name>M3C3V9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UBC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_114054</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF14921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763042.1">
        <property type="nucleotide sequence ID" value="XM_016901072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C3V9"/>
    <dbReference type="STRING" id="692275.M3C3V9"/>
    <dbReference type="GeneID" id="27898209"/>
    <dbReference type="eggNOG" id="KOG0428">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041481_0_3_1"/>
    <dbReference type="OMA" id="YHGRITF"/>
    <dbReference type="OrthoDB" id="1158011at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23799">
        <property type="entry name" value="UBCc_UBE2J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000086">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 J1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="3">
        <location>
            <begin position="37"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="220"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="232"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="258"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF14921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="329" mass="35528" checksum="A2A09A167EEC02DE" modified="2013-05-01" version="1">MDMPHGLYLIEQVALLVPTRTFTFAYLILISDTFMNPTIKRILKEAAELANTPSSDFHAAPLENDLFEWHFTLRGTSQSPYEGGIYHGRIILPPAYPLKPPSFRFVTPSGRFEANREICLSISGHHEETWQPAWGIRTALVAIRSFMDTEAKGQVGGMEASAEVRKRLARQSPKAKCATCGKTNEEIMAEQDEAVKEAGGDAAQKTDVVPEELRLAYREDLGKSGDGPGKQANETAALSSDSSTLQASPAAVNADVRPAQPQPASSSSSSPPPPATAPVAQIAVHTTVAATTQQPLAPPPREEIPAWIDKAIYGILLVLGFMCAHKLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M3C4T4</accession>
    <name>M3C4T4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Magnesium chelatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_147227</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763427.1">
        <property type="nucleotide sequence ID" value="XM_016904159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C4T4"/>
    <dbReference type="GeneID" id="27901296"/>
    <dbReference type="eggNOG" id="ENOG502QQMN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034390_0_0_1"/>
    <dbReference type="OMA" id="HWHDPED"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.80">
        <property type="entry name" value="Magnesium chelatase subunit I, C-Terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052041">
        <property type="entry name" value="Nucleic_acid_metab_PIN/TRAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11603">
        <property type="entry name" value="AAA FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11603:SF132">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF15306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="348" mass="38168" checksum="9432F2562D58526C" modified="2013-05-01" version="1">MASSILARVEELDDVELAILVSTIAEVHCIFSTAAHTVADLQEQLRLTCIDLLGRHPAVVECSADTTVDDFNQGLLVDNNNQEDLQDALDLDYTSARPTLMVNFEPVRQASPGGGRFGSTIANFEDRRIADVIIATGLDAASESVQVQALELLRSGRIFTRSAMHVAPKDLLFITVLSEPNARLTRHLNDSFCMSHYHSPEDTVPHRQSRLGKLAISDAAFSPEEIKHLSELMSKVEMSAEIAQYLHNVAVFMRNSRYVKSGVTAASTRQLRLLALALAPLHGLDYVPPSLITLAARKIYPHRIVLATPQNEKSLLWGSDPQAVKEMLNGVTVEDVIEDVLASVDTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M3C583</accession>
    <name>M3C583_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Eukaryotic translation initiation factor SUI1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_147306</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763532.1">
        <property type="nucleotide sequence ID" value="XM_016904215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C583"/>
    <dbReference type="STRING" id="692275.M3C583"/>
    <dbReference type="GeneID" id="27901352"/>
    <dbReference type="eggNOG" id="KOG2522">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012487_1_1_1"/>
    <dbReference type="OMA" id="MFLKPYR"/>
    <dbReference type="OrthoDB" id="199771at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11608">
        <property type="entry name" value="eIF2D_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21156">
        <property type="entry name" value="PUA_eIF2d-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.780.10:FF:000008">
        <property type="entry name" value="eukaryotic translation initiation factor 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039757">
        <property type="entry name" value="EIF2D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039759">
        <property type="entry name" value="eIF2D_SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041366">
        <property type="entry name" value="Pre-PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048248">
        <property type="entry name" value="PUA_eIF2d-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058886">
        <property type="entry name" value="SWIB_eIF2D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057429">
        <property type="entry name" value="WH_eIF2D"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12217">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12217:SF4">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17832">
        <property type="entry name" value="Pre-PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26292">
        <property type="entry name" value="PUA_elF2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26291">
        <property type="entry name" value="SWIB_eIF2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25304">
        <property type="entry name" value="WHD_eIF2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUI1" evidence="3">
        <location>
            <begin position="549"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="399"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="407"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF15411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="644" mass="70268" checksum="C757E321CB32822A" modified="2013-05-01" version="1">MFKKKPHIKALSPLRSSDRRKLADQIIKDFALGGKEAPTNDDTPEQKAEATAAHTALRNSLLPENVQSARFTTTHGPELKQVSGTIYVGHHDGEDARILWFQTDGRMVPSVYTLWHNADIVPLLHTPEIVVKKMVGGADLMIPGLFGGPPFPPRAKKGAVVAVAALEKPTVPVAVGFCEIDVSALQKVRGEKGHAVENMHWLGDELWSYGTGSRPGRQAPDAIEGWAKVLQERGLLEQVANLDLEEENEVGGVALEDGALGQDKTVAESSRMSTNGSELVKTSEAKELSQQDIDNAFRNAFLFGVNHYKTSNPSAKNHGLDYPLTQTVIMSTLVQPFLPAFSSEEAQQLQIKKTSWKNIKKFVKSLDKAKIVESKDSGNETTIVDIDFEDPAITTFKPYRLPKKESSGGPSNGPGNEKTDGADDSIGQKIQVVSSYRPSTKLQPIFDAATGTKSLYTPAEVRDLVSSYLEKERLISETNKRLVKLNPILANAVFDGSGSLDKEVLAKGTVPRDALLDRILHAMSPQYAIVRQGTDPNSVKPKSGAPPKVHITLETRSGNKTVTKVSGLEVYHIDPRPLADELRKVCAGSTSVEPLAGASKKNEKEVLEVMVQGPQKDAVVRALEKRGIDKRWVEVLDKTKGKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>M3C640</accession>
    <name>M3C640_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_80792</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763862.1">
        <property type="nucleotide sequence ID" value="XM_016910257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C640"/>
    <dbReference type="GeneID" id="27907394"/>
    <dbReference type="HOGENOM" id="CLU_2484753_0_0_1"/>
    <dbReference type="OrthoDB" id="1924260at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF15741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="87" mass="9979" checksum="3DE69EBD789A654A" modified="2013-05-01" version="1">MPRDNELRGTDIRKRARHRLCCRCRRELIAPVVAPKTFGLSSLPKFAEGMLTTSYCRCTFVSCCSNNAMVQHKYGIFETPVTSTHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M3CD59</accession>
    <name>M3CD59_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zn-dependent exopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_150045</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759122.1">
        <property type="nucleotide sequence ID" value="XM_016905932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CD59"/>
    <dbReference type="STRING" id="692275.M3CD59"/>
    <dbReference type="GeneID" id="27903069"/>
    <dbReference type="eggNOG" id="KOG2195">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005688_1_0_1"/>
    <dbReference type="OMA" id="YPRKDGR"/>
    <dbReference type="OrthoDB" id="5841748at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08022">
        <property type="entry name" value="M28_PSMA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02121">
        <property type="entry name" value="PA_GCPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000101">
        <property type="entry name" value="N-acetylated alpha-linked acidic dipeptidase like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.40">
        <property type="entry name" value="Transferrin receptor-like, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039373">
        <property type="entry name" value="Peptidase_M28B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007365">
        <property type="entry name" value="TFR-like_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036757">
        <property type="entry name" value="TFR-like_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404:SF71">
        <property type="entry name" value="CARBOXYPEPTIDASE TRE2, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10650)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404">
        <property type="entry name" value="N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04253">
        <property type="entry name" value="TFR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47672">
        <property type="entry name" value="Transferrin receptor-like dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="4">
        <location>
            <begin position="342"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="6">
        <location>
            <begin position="535"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin receptor-like dimerisation" evidence="5">
        <location>
            <begin position="797"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF11001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="938" mass="105718" checksum="4700CDCD7BAD44FC" modified="2013-05-01" version="1">MDMNDDEDDDKYVRYAHVPIPSYEDAIQRPNSSQNHGQAEQEREGLLDQHGRTRSYQPPTAESPRSSEDSDLRLPEVDGDDNDERRRVEELDYLDPSTADPDSRRAGLYHRSRIRSKFSQHLSNLGATLSSLRLPSFRSLYTPVQSELEQNNNNNNNENDHENENSSEPPRRWAWLYRPLPSLPVQYRMGAATAARLCGLMSIAILIYVLFILDVFPNSGRYIGTRFDPESVRSYVQENVDAARIEEYLYHITGYDHVAGTEGDLYMAEWMKGKWEEEGHLDSVALRSYYVYLNYPKQDGRSVSIVAPENKKWKAKLEEERADPVKQQTWAWHGHSKNGLVEGHLIYANGGNREDFAWLRDQGVTLNGSIALMRYYSTQGDRALKIKAAEDAGCIGALIYSDPTEDGSVRGPVWPEGPWRSEDSLQRGGVSLMSWIAGDPLTPGYASTKDAKVHDKENNPGLVGIPSLPLSWRDAKVLLESLSGHGVQVPKEWVGGDKSFTKEWYSGASPDKSSDTPIVNLKNHNDENDKQQIWNLHGLIEGLEQPEKKILIGNHRDSWCFGSVDPGSGSAVMMEMVRIFGALRKLGWRPLRSIEFISWDAEEYNLVGSTEYVEDNMEALREDAVAYLNIDVGVYGPDPVFRAAGSPVWERPLLHILDRVNTPSGSATLRQIWDDRKSKLEGLGAGSDYVAFQDMAGTSSIDFGFEGPEYGYPYHSCYETFDWMKRFGDPDFGWHRTLGQLWALLILEIADRPIVPFDLRSYADALDGPYLDTLQNYATSQLQKLGQSTPSDNKTEIDISSLKEAAQHLKSVASHFHKFEDLWTTNVLGTGGLETSSYAIRRLAYNDALSTFETDLLDIPSSPLDTDQHGVPGREQFKHIVFGPQAWSGYDEAYFPAVRDALDVGDWALAQKQVDKAADILERAIKRLEGKGRKLMLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M3CEG8</accession>
    <name>M3CEG8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribulokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_150377</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759562.1">
        <property type="nucleotide sequence ID" value="XM_016906129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CEG8"/>
    <dbReference type="STRING" id="692275.M3CEG8"/>
    <dbReference type="GeneID" id="27903266"/>
    <dbReference type="eggNOG" id="KOG2517">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009281_10_1_1"/>
    <dbReference type="OMA" id="HKAMWHE"/>
    <dbReference type="OrthoDB" id="203824at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019150">
        <property type="term" value="F:D-ribulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019321">
        <property type="term" value="P:pentose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07782">
        <property type="entry name" value="ASKHA_NBD_FGGY_D-RBK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006003">
        <property type="entry name" value="FGGY_RbtK-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01315">
        <property type="entry name" value="5C_CHO_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43435:SF4">
        <property type="entry name" value="FGGY CARBOHYDRATE KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43435">
        <property type="entry name" value="RIBULOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="5">
        <location>
            <begin position="35"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="6">
        <location>
            <begin position="337"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF11441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="616" mass="67632" checksum="FA54B02296996EDA" modified="2013-05-01" version="1">MSQTAGLPYRNPSRQQSRQMSVDPHNELRPELNHYIGIDVGTGSARACIMNDRGDIVGLASENIGLWQPETGFYEQSTTNIWKCICNSIQRAMSQHNIDPNTIRGIGFDATCSLTVFDRETDQPVSVTGPKFDNADGNDRNVILWLDHRPVEETKKINATNHNLLRYVGGQMSIEMEIPKVLWLKNNMPKELFDRCKFYDLGDALTHMATGSESRSFCSVVCKQGYVPVGVDGSVKGWQEDFLTEIGLADLCEDNFKRMGGVNGVNGHYLTAGELIGTLSEKAGAEMGLPAGIAIGSGVIDAYAGWIGTVGAKVNLRGDSIDAGKPKNDVSQAFTRLAAVAGTSTCHLAMSEKPVFVNGVWGPYRDVLIPNYWLAEGGQSATGELLKHVVETHPAFQEAMSLAESFNTNIYDYLNEHLSEMQEKTRAPAISYLGRHFFFYGDLFGNRSPVADPDMKGSIIGLSNDKSIDGLALYYYGTMEFIALQTHQIIEQMNSAGHIISSIFMSGSQCQNPVLMSLMATACNMPVLIPRYVHAAVVHGAAMLGAKAASTDKNGVSEPLWDIMDRMSKPGKAVYPNKDVGEQKLLQAKYKVFLKQCEEQRSHRQDIDDAISGWKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M3CEK9</accession>
    <name>M3CEK9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">GTP-binding protein rho2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_142925</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759602.1">
        <property type="nucleotide sequence ID" value="XM_016903019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CEK9"/>
    <dbReference type="STRING" id="692275.M3CEK9"/>
    <dbReference type="GeneID" id="27900156"/>
    <dbReference type="eggNOG" id="KOG0393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_21_2_1"/>
    <dbReference type="OMA" id="NDNVMRR"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035841">
        <property type="term" value="C:new growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035840">
        <property type="term" value="C:old growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030950">
        <property type="term" value="P:establishment or maintenance of actin cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902660">
        <property type="term" value="P:negative regulation of glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903139">
        <property type="term" value="P:positive regulation of cell integrity MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070610">
        <property type="term" value="P:regulation of fungal-type cell wall (1-&gt;3)-alpha-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000573">
        <property type="entry name" value="RHO family GTPase Rho2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF11481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="201" mass="22351" checksum="15BFD2058C45614D" modified="2013-05-01" version="1">MAQSQEQQVMRRKLVIIGDGACGKTSLLSVFTLGYFPTRYVPTVFENYVTDCRVDGKSVQLALWDTAGQEDYERLRPLAYSQAHVILIAFSVSSPDSLQNITTKWHPEVLDRCPGVPIILVGLKKDLRDDPVAQEEMRKRSEKFLTSDEGEDVRKRIGAKKYLECSSLTGEGVDDVFEAATRQSLLSGGKEGNSRGCCTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M3CF08</accession>
    <name>M3CF08_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_149077</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760499.1">
        <property type="nucleotide sequence ID" value="XM_016905326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CF08"/>
    <dbReference type="STRING" id="692275.M3CF08"/>
    <dbReference type="GeneID" id="27902463"/>
    <dbReference type="eggNOG" id="KOG1577">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_0_1_1"/>
    <dbReference type="OMA" id="YCLQKNW"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000015">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF13">
        <property type="entry name" value="ALDO_KETO REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="6">
        <location>
            <begin position="31"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="5">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF12378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="284" mass="31357" checksum="4093D0A5FBDF4010" modified="2013-05-01" version="1">MASLTLNSTISLQSGTRLPSLGFGVWDSPSHKTVQSCLSALEAGYRHIDTAQVYGNEVEVGEAVRQSQLARKDVYLTSKILSPAEDAESTYQKCLQSVQKIAGDDGYLDLLLIHNVSSGAAGVKLMWQAMERLFQEGKLRAIGMSNTGIGMMEAMKAYATVWPPHVNQLELHPWCQQREVVEYCHKNGIAVEAYCPLVRNQKANDEDLKAIADKHGKSTPQVLVRYCLQKNWVPLPKSDTPSRIKQNADIYDFALSDEDMATLDKKDQGAKGALVQIADNESTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M3CFA3</accession>
    <name>M3CFA3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">U3 small nucleolar ribonucleoprotein protein IMP3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">U3 small nucleolar ribonucleoprotein protein imp3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_156204</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760609.1">
        <property type="nucleotide sequence ID" value="XM_016907663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CFA3"/>
    <dbReference type="STRING" id="692275.M3CFA3"/>
    <dbReference type="GeneID" id="27904800"/>
    <dbReference type="eggNOG" id="KOG4655">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097281_0_0_1"/>
    <dbReference type="OMA" id="FRIKHEQ"/>
    <dbReference type="OrthoDB" id="10448516at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140691">
        <property type="term" value="F:RNA folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000006">
        <property type="entry name" value="U3 small nucleolar ribonucleoprotein IMP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_uS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS4 N-terminal" evidence="12">
        <location>
            <begin position="4"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-binding S4" evidence="11">
        <location>
            <begin position="113"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF12488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="187" mass="21660" checksum="CE2CAFB1361776DF" modified="2013-05-01" version="1">MVRKLKHHESKLLRKVDFINYKSDDNHRQAEIVRRYSISKPADYTSYNRLCGKLRHLAHRVALLPPDSLFRRKQEDLLLEKLHDMGLLGVGGSGTGKLSDVERKITVSAFCRRRLGVVMTRLRMAETVSAANKFIEQGHVRVGTEVITDSAFLVTRNMEDFVTWVDSSKIKRNIMKYRDKLDDFDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M3CVR9</accession>
    <name>M3CVR9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_152477</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF08237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756358.1">
        <property type="nucleotide sequence ID" value="XM_016907468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CVR9"/>
    <dbReference type="STRING" id="692275.M3CVR9"/>
    <dbReference type="GeneID" id="27904605"/>
    <dbReference type="eggNOG" id="ENOG502S84A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093522_2_1_1"/>
    <dbReference type="OMA" id="MSRVANW"/>
    <dbReference type="OrthoDB" id="4590138at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39474:SF1">
        <property type="entry name" value="FUNGAL SPECIFIC TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39474">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF08237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="163" mass="17800" checksum="423FE1F3B0760D0E" modified="2013-05-01" version="1">MSRPYNLLVTSIVTVLAIFIGLQFQSPDSLLMRFITPYSASILPQARRAFAPIASTFSTFPPTMSSSTSNRDAENAVDGQPLGLPSPPSKEEEAAMKLDMSSGSDTIKLDHLGPLVVNKDGSLSRISNWEQMTAQEKKSTLKILGKRNQLRTDALKESEDTIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M3CWH0</accession>
    <name>M3CWH0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_74686</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF08016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756137.1">
        <property type="nucleotide sequence ID" value="XM_016910076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CWH0"/>
    <dbReference type="GeneID" id="27907213"/>
    <dbReference type="eggNOG" id="ENOG502QZI3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036934_1_1_1"/>
    <dbReference type="OMA" id="AWLRIMQ"/>
    <dbReference type="OrthoDB" id="2590011at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF6">
        <property type="entry name" value="AP-1-LIKE TRANSCRIPTION FACTOR YAP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="4">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="121"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="260"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="323"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="128"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="289"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="323"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="340"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF08016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="456" mass="50623" checksum="A670E64D5CCCC087" modified="2013-05-01" version="1">MNSQRPLATEGSSSISSMSVSSHGESPLQPLGPLAATDLQRTKKKPGPKRDSKPAQNEKLERNRQAQRTHRERKEQYTKDLEIEVMRLKELFAQATRERDGAIQTRDAALVERDQLLEENQRMREYIQPSNSSSGRDSGYDSMSWTCDSGSSHSDTSGPNLTANAPLQEVADSHIALRRASTRDMAETRGFTFDIPPSDSYTIKVEDTMQRDHSNSAIIAQLPTELPAPPLDYDALGLDFVLTLERPCMGHIQYLHIRAHNNNNPPPPSSSSLPSSSSSSTTTTIPLSPHLPTPTPPEDVPNDNENLHISGHALMATAPSYTSIMQHHQQQQHPASKTTTPPPYTPQFPPFTQRKDLIHLLNLSANLQICEQEVPPVRAWVKLMQNPRVRNSFGCEELEEVKEWLVGKVCCYRFGAVVDQNDIDEAVAHVCQKLEEKRGSSNTRGGGTSNSIITQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M3CXU7</accession>
    <name>M3CXU7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">T-complex protein 1 subunit eta</fullName>
            <shortName evidence="9">TCP-1-eta</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CCT-eta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_93158</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterooligomeric complex that forms two stacked rings.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757018.1">
        <property type="nucleotide sequence ID" value="XM_016910604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CXU7"/>
    <dbReference type="STRING" id="692275.M3CXU7"/>
    <dbReference type="GeneID" id="27907741"/>
    <dbReference type="eggNOG" id="KOG0361">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008891_7_1_1"/>
    <dbReference type="OMA" id="HRKGNTW"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03340">
        <property type="entry name" value="TCP1_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000022">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000006">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012720">
        <property type="entry name" value="Chap_CCT_eta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02345">
        <property type="entry name" value="chap_CCT_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="526"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="547"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF08897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="557" mass="60838" checksum="185A8FF9BF6977D4" modified="2013-05-01" version="1">MSFGGQTPTIIVLKEGTDQSQGKGQIISNINACLAVQSTIKSTLGPYGGDLLLVDENGKQTITNDGATVMKLLDIVHPAARILTDIARSQDAEVGDGTTSVVVLAGEVLKEIKEHVEQGVSSQVIIKGLRRAGTMAVNKVKEIAVSTSEDNQRETLRKLARTAMSSKLIYRNEQFFTKMVVDAVLSLDQDDLNEKLIGIKKITGGALQDSLFVNGVAFKKTFSYAGFEQQPKAFKNPKIVCLNVELELKSEKDNAEIRVEQVSEYQAIVDAEWKIIYDKMEALYNTGAKVVLSKLPIGDLATQYFADRDVFCAGRVSSDDLERVCQATGASIQSTCSDISSHHLGTCEVFEERQIGGERYNFFEGCPGAKTCTLVLRGGAEQFIAEVERSLHDAIMIVKRAIKNQTIVAGGGACEMEVSAYLHSFADKNVPHKQQSIIKAFAKALEVIPRQLCDNAGFDATDILNRLRVEHRKGNTWAGVDFDNEGIRDNLEAFVWEPSLVKINAIQAAVEASCLILSVDETIKNQESQNPQAPTRGLPPGAAQRAMRGRGRGMPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M3CXY9</accession>
    <name>M3CXY9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable cytosolic iron-sulfur protein assembly protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CIA1</name>
        <name evidence="6" type="ORF">SEPMUDRAFT_74292</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat CIA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756667.1">
        <property type="nucleotide sequence ID" value="XM_016910060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CXY9"/>
    <dbReference type="STRING" id="692275.M3CXY9"/>
    <dbReference type="GeneID" id="27907197"/>
    <dbReference type="eggNOG" id="KOG0645">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_8_1"/>
    <dbReference type="OMA" id="IREIRWS"/>
    <dbReference type="OrthoDB" id="284782at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03037">
        <property type="entry name" value="ciao1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028608">
        <property type="entry name" value="CIAO1/Cia1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920:SF0">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR PROTEIN ASSEMBLY PROTEIN CIAO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920">
        <property type="entry name" value="WD40 PROTEIN CIAO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="58"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="142"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="187"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="101"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF08546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="444" mass="49669" checksum="819CF8DE536CC5F5" modified="2013-05-01" version="1">MAIQVPKLSELAVFNPPCTTRTWLSTPHPHLPIIATACSDKTVRIYSLQSFQQLSVIAGGHKRSIRSCAWKPNSVGESVLATGSFDASAGIWKRWEEGAGTGTIGGRDNHEEGERDFTGGLAGGDGEKDGEDDEEWRLEVILDGHDSEIKSLAFCPTAPLLATCSRDKSVWVWEELDEDNFETMAVLQDHEGDVKCVAWHPEEQLLASGSYDDRIRLWREDVDDWACCTLLDGHAGTVWWLEFEASTRVGKVEGGEGRTDEQKALLEERTKAGARLMSCSDDKTIRVWRRKPKEKSEPAPTGQGRMPSIWKNNNFEEDWIEEARLPQLHDRPIYAVSWSKKTGRVVSAGSDGIIVVYEERWRREKPVDIEMANTTPEAVNGATERPANLTEWVVVAQIENAHDVFEVNHVTWAPRYDKGKRSDDEEIVISTGDDGDVKAWVLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M3CYJ3</accession>
    <name>M3CYJ3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Molybdopterin binding oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_73691</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF09147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757268.1">
        <property type="nucleotide sequence ID" value="XM_016910039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CYJ3"/>
    <dbReference type="STRING" id="692275.M3CYJ3"/>
    <dbReference type="GeneID" id="27907176"/>
    <dbReference type="eggNOG" id="KOG0535">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003827_5_5_1"/>
    <dbReference type="OMA" id="ERHHAGI"/>
    <dbReference type="OrthoDB" id="10051395at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008482">
        <property type="term" value="F:sulfite oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="entry name" value="Oxidoreductase, molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005066">
        <property type="entry name" value="MoCF_OxRdtse_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008335">
        <property type="entry name" value="Mopterin_OxRdtase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372:SF7">
        <property type="entry name" value="SULFITE OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372">
        <property type="entry name" value="SULFITE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03404">
        <property type="entry name" value="Mo-co_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00407">
        <property type="entry name" value="EUMOPTERIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="Oxidoreductase molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase molybdopterin-binding" evidence="5">
        <location>
            <begin position="42"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Moybdenum cofactor oxidoreductase dimerisation" evidence="6">
        <location>
            <begin position="225"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF09147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="344" mass="38608" checksum="23F2B4E92647A016" modified="2013-05-01" version="1">MSSDERRACLSMTPGFHLRPPPPPHQLDSFITDDGKLFQTIHMGRPNLDHSLWHLRIHGLVERSYTLTLSELYTLPRTTITSFHECYGSPLQPPTTNLWRIGNVEWTGIRLRDLLNHAKPLAQAAFVWSDGLDSGSFGGVSADRYQKDLPLAKAMSPEVLVAYEMNGKALSLERGGPVRLVVPGWFGTNSTKWLCSLQLREERSSGPFTTTFYNEWVSSGRMRPVWDVEPNSMMVSPRNGDILLTANTTDGTSTLDAKVWGWAWSGDGIEVVEISLDDGLSWRGTTVAPRSQWEWQSFSIVLKLDVGVHRMSARATSNSGVKQALQGRRNHIHRISFRVERPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2022-12-14" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>M3CZU4</accession>
    <name>M3CZU4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_135216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF09768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757889.1">
        <property type="nucleotide sequence ID" value="XM_016902693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CZU4"/>
    <dbReference type="GeneID" id="27899830"/>
    <dbReference type="HOGENOM" id="CLU_1316135_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="209" mass="22491" checksum="86CB4B194DDF2CB2" modified="2013-05-01" version="1">MGTVRDEMDAAAGGPRSWNGRLNSAGAVACTPLDYLRPQRPSTFHSPLSTIITDRSLQPVPEPPLLGAAQKQAHASFTTSPRAQPRAFDWGCLYSSQTMPERAADNDSEAARAAMCANMEGRMMLWDGVGRLPRQRSTRPGNSAARPIAGSCAAQENNLNLDDNNNNKNPLHDSSVQFGLATTAHLLWSARLDAGIIFRLVAVGGRCHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M3CZY4</accession>
    <name>M3CZY4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_151201</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Classic Zinc Finger"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
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    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
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    </dbReference>
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    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
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    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="470"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="499"/>
            <end position="521"/>
        </location>
    </feature>
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        <location>
            <begin position="128"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="364"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="535"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="596"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="364"/>
            <end position="375"/>
        </location>
    </feature>
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        <location>
            <begin position="414"/>
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        </location>
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            <begin position="430"/>
            <end position="453"/>
        </location>
    </feature>
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        <location>
            <begin position="598"/>
            <end position="609"/>
        </location>
    </feature>
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            <begin position="614"/>
            <end position="630"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMF10199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="630" mass="68381" checksum="B34F902A9AACF398" modified="2013-05-01" version="1">MEYAAQTTPPMGQSPFFYYQPEPSPDTKQHGHFAPHPHYHPGLPMAIVPSSPGQVMYFHQPPMQHQYRPQSAGSYSHYQQHAQAYGPPPMLTPDASPRQHQRLGYFMPQQEAQGLIVNTECHNYHPATPTHSATSGSFSSASTPPSTCGLQPTPVDGQGVFFAKPPMSAYPAIKQGCEEEVHLEVLAGGDWSTRPGSPPMTPVFLHNSISAESSQAAAAAYEMASGATLLQHSPCTSPASPMSRSAATEQEVCDPRDLMSSTSGVDFHAMPALCNGDETGEFKVTTTTTTTAFKSDISPPQVHIAEAAEPRFYAGLPTFEPIFELDVEDEFGGMVSYSASHDVQYNGAKRQRLSVASGVDDDGFFSEESYSDDELAPGAYSPPVSDYPIPEDSAAAHSKPKRKTSRKETVLQHAAAQSTAQEASSAPTSNAPSQASSENNETAASTPAQSGSVSRRGRKQSLTDDPSKTFVCTLCSRRFRRQEHLKRHYRSLHTHEKPFECSDCGKKFSRSDNLSQHQRTHGAGTMVMGVLSQPGEQHMHHQPIESVNGGDAGSVIRPKQEQQQQYTPQPLQYAQHHRLSPDTGELGAMLFDVTAQVSGSSSSSSSMGYSEDEFTAHGDQKPARKRKRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M3D060</accession>
    <name>M3D060_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_110646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016900856.1"/>
    </dbReference>
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    </dbReference>
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            <begin position="1"/>
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        </location>
    </feature>
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            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
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        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
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        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF10269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="170" mass="18822" checksum="E8BD016B0BA0EDDE" modified="2013-05-01" version="1">MAPATKSKKPVAAAAAATESIISSQSAHGESDVETPQSQSQQIDTEMLKLAIKKSKEQSTTLKAKREKEIERKHKQRLSKLQKKIDEAHKQQQDTAAVTKRVPTTEQPDAKSTNPNSTVSRPFSPEDETSKTNGYGRSIPSDSLGKLRSNKSNKRSRITRQDTRKLLGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M3D0C7</accession>
    <name>M3D0C7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_151027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF09933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016906548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D0C7"/>
    <dbReference type="GeneID" id="27903685"/>
    <dbReference type="HOGENOM" id="CLU_2528899_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="84" mass="8791" checksum="EBDC7B224F94BDCE" modified="2013-05-01" version="1">MTRGSLHVAGVFILLPVKWTGGGCSAGVVAWFYPDGGCSRSRRLAGLTSAIKHSGSSAERLAGVEVKLEHWARHSTTVAVASAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M3D0J6</accession>
    <name>M3D0J6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA(adenine(34)) deaminase</fullName>
            <ecNumber evidence="3">3.5.4.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_26873</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>adenosine(34) in tRNA + H2O + H(+) = inosine(34) in tRNA + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:43168"/>
            <dbReference type="Rhea" id="RHEA-COMP:10373"/>
            <dbReference type="Rhea" id="RHEA-COMP:10374"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:82852"/>
            <dbReference type="EC" id="3.5.4.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family. ADAT2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.33" evidence="3"/>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759164.1">
        <property type="nucleotide sequence ID" value="XM_016908419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D0J6"/>
    <dbReference type="SMR" id="M3D0J6"/>
    <dbReference type="STRING" id="692275.M3D0J6"/>
    <dbReference type="GeneID" id="27905556"/>
    <dbReference type="eggNOG" id="KOG1018">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025810_8_1_1"/>
    <dbReference type="OMA" id="PCQMCAG"/>
    <dbReference type="OrthoDB" id="1701769at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052718">
        <property type="term" value="C:tRNA-specific adenosine-34 deaminase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000039">
        <property type="entry name" value="tRNA-specific adenosine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF149">
        <property type="entry name" value="TRNA-SPECIFIC ADENOSINE DEAMINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="9">
        <location>
            <begin position="10"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF11043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="183" mass="20223" checksum="61857BD29529E2C6" modified="2013-05-01" version="1" fragment="single">MVFGPIPDREYHEGFMREAIGMAEFALASDETPVGCVFVHEGKIIGRGINGTNASLNGTRHAEFVALAEIMSKHPQSILHQTDLYVTVEPCIMCGSALRQYGIRAVYFGCLNDRFGGCGGVMNVHSDPGIDSTFPCYGGLFREEAIMLLRRFYVQENEKAPDPKPKKNRELKTEILPVTVTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M3D142</accession>
    <name>M3D142_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Stress response protein ish1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_150193</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759314.1">
        <property type="nucleotide sequence ID" value="XM_016906012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D142"/>
    <dbReference type="STRING" id="692275.M3D142"/>
    <dbReference type="GeneID" id="27903149"/>
    <dbReference type="eggNOG" id="ENOG502RNIV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_698261_0_0_1"/>
    <dbReference type="OMA" id="NYPGDWL"/>
    <dbReference type="OrthoDB" id="2527403at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018803">
        <property type="entry name" value="Ish1/Msc1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10281">
        <property type="entry name" value="Ish1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032149" description="Stress response protein ish1" evidence="2">
        <location>
            <begin position="17"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF11193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="445" mass="47434" checksum="DC65E697B01E82AF" modified="2013-05-01" version="1">MRFSLAVAALATTVAADGWFGKSGRIAYNKWHETELERWLSDHDVPYPTPADRKDLENLVKDNWDNYAVKPYNSWDANQLQNYISSKGQQVKKGTEKNKDSLLQQVQDLWHETADQTNEAYGSVQNWIFDSWTESQIKAWLDYHKIPNPSPRTRDSLLHTARANYAKAAEKAGETAAYPGNWLYSQWSDSDLKAWLDERGVPVPQPGNRDKLIATLRRNSKIAADKASQQYASASKSAAGAAQSLSDQLLESWSDSQIKEWADRNGIKVPQGSKRNELIALARKHSASLTGNNAKDSAASAYGAATSSAGNYYAEATQGAYSQFQYYYDVIANNLGFASEEAKKSLSSASSVASASASSASSVASVSASSASSVASASASSLSSSASKYGPKSASSLSASASSASSVASVSASKSASSASVAASKSISSESVAASKSAQSVKNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>M3D215</accession>
    <name>M3D215_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Signal peptidase complex catalytic subunit SEC11</fullName>
            <ecNumber evidence="4 15">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SEPMUDRAFT_118821</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the signal peptidase complex (SPC) composed of a catalytic subunit SEC11 and three accessory subunits SPC1, SPC2 and SPC3. The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates. This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids. SPC associates with the translocon complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase S26B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="4 15"/>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759664.1">
        <property type="nucleotide sequence ID" value="XM_016901457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D215"/>
    <dbReference type="STRING" id="692275.M3D215"/>
    <dbReference type="MEROPS" id="S26.010"/>
    <dbReference type="GeneID" id="27898594"/>
    <dbReference type="eggNOG" id="KOG3342">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089996_0_0_1"/>
    <dbReference type="OMA" id="ILMNEYP"/>
    <dbReference type="OrthoDB" id="10257561at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009003">
        <property type="term" value="F:signal peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019756">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001733">
        <property type="entry name" value="Peptidase_S26B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02228">
        <property type="entry name" value="sigpep_I_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806:SF6">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00728">
        <property type="entry name" value="SIGNALPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SPASE_I_1"/>
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    </dbReference>
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    <keyword evidence="9 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMF11543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="174" mass="19106" checksum="67AAA7BB0ED2BE0C" modified="2013-05-01" version="1">MLNAVAGLQPRQLAAQILNFALVLSTAFMLWKGLSVVTDSSSPIVVVLSGSMEPAFQRGDLLFLWNRGMETQVGEVVVYSVKGKDIPIVHRVVRRFGGGAKPLQLLTKGDNNAADDTELYARGQSYLERSKDVIGSVVAYVPFVGYVTILLSEYPWLKTAMLVFMALTVVLQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M3D217</accession>
    <name>M3D217_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mediator complex subunit 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_126746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016902099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D217"/>
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    <dbReference type="GeneID" id="27899236"/>
    <dbReference type="eggNOG" id="ENOG502SEH4">
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    </dbReference>
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    <dbReference type="OrthoDB" id="5326237at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF11152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="129" mass="14501" checksum="05EE55D147A04975" modified="2013-05-01" version="1">MADTQQATQDAQLVGEADEPAWEEKQYKEALAHLERLQEQIDGMRRTIPSMIEPMARPVPGKDKARLVLQMKTAAVQAVDEVQALRNNWNSGKTQALITKSRESFQKDGDLSKAADISRYGWAEDVNMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M3D2B3</accession>
    <name>M3D2B3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AAA-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_126849</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759398.1">
        <property type="nucleotide sequence ID" value="XM_016902106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D2B3"/>
    <dbReference type="STRING" id="692275.M3D2B3"/>
    <dbReference type="GeneID" id="27899243"/>
    <dbReference type="eggNOG" id="KOG0730">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_12_3_1"/>
    <dbReference type="OMA" id="KPPTIHW"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="ATPase family, AAA domain-containing 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF27">
        <property type="entry name" value="ATPASE FAMILY GENE 2 PROTEIN HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="269"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="555"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF11277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="787" mass="86519" checksum="E6EFB450ABFC9F11" modified="2013-05-01" version="1">MDASHVVVRLQQSKGLQDAFRVHLLPESLTDAGLKLNDLCHIISEDGNTTGYGIAWRAEDKMGSRPKLRPAKMSETFRDLYDFKDGSKVRVTRTETKLYPADKIVLYDVTPEGHNKPDAVDETNWEWRIGSLFEESDALAPGVSFEVVGAKKFRRRFHVESIESAIAPTIDANCLYRVRRGTVITLPGGTSTRPNTASSVGQFSTSGINHAVQLPGRNGDTAPFHGHTRHGIDTHRIGGLLEQIQRLNRQIRRLLDTAFDINYFGSGIANPAVLLHGYQGCGKTTLLDAIAESGFRKVFRLKRQVLVSGTLSKGRTEIQDTFQEAVLPANQPSLIVIDDLDKLASADDDKFSDTLLEQIKQARSSRVMIVAACRSLASLPDTLVRADGFSKHIEIPIPDVTARQQISDVLCQKLDLVKSNIPQQIASRTHGFTGDDLKQLYIQAVECALDRAERHSADRDSDILPGLPTYSEANGLSESAFHPSSTTAVYDIKLEDFDRALTSIVPTALREVFTDKPKVKWSDIGGSDKVRDSFDHIIGQQQQHKALFAEFRRKPEKGVLLYGPPGCSKTLTAQAVATSYKFNFISIKGAELISKYVGDSEARVREVFQKAKTAAPCVIFFDEIDAIAASRDEGSQSGLNVLTTLLTEMDGFEALKDVFILAATNKPEALDPALMRPGRFDSHVYLGPPNIAARQDIFRIACDGVPLAESVKFASLAGLTDGYSGAEIVRICDVAKDLTMRRIGLAEPGSRHITMDEFKAAIREVKKGITKEMLDAYAKFATRGDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M3D2J7</accession>
    <name>M3D2J7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_48148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759488.1">
        <property type="nucleotide sequence ID" value="XM_016909056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D2J7"/>
    <dbReference type="STRING" id="692275.M3D2J7"/>
    <dbReference type="GeneID" id="27906193"/>
    <dbReference type="HOGENOM" id="CLU_1199798_0_0_1"/>
    <dbReference type="OMA" id="DGECCRH"/>
    <dbReference type="OrthoDB" id="3932237at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF1">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF11367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="24710" checksum="3C284D138D29CB07" modified="2013-05-01" version="1">MARRDSAIDVVKDTNDDHKPPRPRQSPASLLSRLPDELLLIIWEYSVISPEPLDLNCPCDSSFGGWTEAYYNEREAWDLRQRCPPWQPALTRVCRSIRADALPMFYKHNAFRAGYCYECDTEIVTDWLKVIGQQNREMLREFYFVDANPSHDRYSPKCLKRVLRGDVVRSLGGRLQSTYTSEACRHDVSFVRRDGEEMEGVQRLFEELLWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M3D2V5</accession>
    <name>M3D2V5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Lectin family integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_149191</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760676.1">
        <property type="nucleotide sequence ID" value="XM_016905399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D2V5"/>
    <dbReference type="STRING" id="692275.M3D2V5"/>
    <dbReference type="GeneID" id="27902536"/>
    <dbReference type="eggNOG" id="ENOG502QR1C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053733_0_0_1"/>
    <dbReference type="OMA" id="WSAEFQF"/>
    <dbReference type="OrthoDB" id="10265193at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005537">
        <property type="term" value="F:D-mannose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051136">
        <property type="entry name" value="Intracellular_Lectin-GPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005052">
        <property type="entry name" value="Lectin_leg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223:SF28">
        <property type="entry name" value="LECTIN, MANNOSE BINDING 1 LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223">
        <property type="entry name" value="VESICULAR MANNOSE-BINDING LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03388">
        <property type="entry name" value="Lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51328">
        <property type="entry name" value="L_LECTIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004033049" evidence="7">
        <location>
            <begin position="25"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="424"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="L-type lectin-like" evidence="8">
        <location>
            <begin position="31"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF12555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="454" mass="49549" checksum="C3E3D78FB4FD9CCB" modified="2013-05-01" version="1">MMALLRIPQSLAWLALALVRVASAETLPIDSLSFGHHGELTPHHAIPGWRQNGYNHAVQVMRNGIILTPPVPGNAKGALWSEAPVGEVTDWTAQLEFRASGQEMGSGNLQFWYTQNPDTVGVNSVYNVEKFDGLVIVIDQYGGSGGKIRGFLNDGSVNFLTSAFLESLAFGHCDYSYRNLGRPSKLKITNQGGLTVTIDDKTCFSSNQIALPAGNNYHFGLTATTGENPDSFEVQAFAVTAGGDLATGTKATTSHPKQGEEAAYQKMSKMDTMPGAPEMLPDRDADSIKSQADQFADLHNRLQGLSHHMGTLYYEIKTISDKLDTTRTEVVQKVGTISGGSGGGSRDTGIPPETVGKINALHDRVSSIESVVNIIRNDLEGKDYKQSMDELHTAMSFLHHNFHTGMDGKLESAIRTHGPSTTQMIFTIIGFQMLMVLGYAWYKRQRHSQPKKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>M3D2Z2</accession>
    <name>M3D2Z2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_149222</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760716.1">
        <property type="nucleotide sequence ID" value="XM_016905424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D2Z2"/>
    <dbReference type="GeneID" id="27902561"/>
    <dbReference type="HOGENOM" id="CLU_2672689_0_0_1"/>
    <dbReference type="OrthoDB" id="3641289at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF12595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="75" mass="8517" checksum="6E4051467B9B405E" modified="2013-05-01" version="1">MGNPQAEMVSELKYRPNVCTSVCTSTKLRLRTYCTSRGALRQPANSSATYRPFHCDRLNFRSSVVHNARRLLNSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M3D3P1</accession>
    <name>M3D3P1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_163867</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760956.1">
        <property type="nucleotide sequence ID" value="XM_016908088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D3P1"/>
    <dbReference type="GeneID" id="27905225"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_1_0_1"/>
    <dbReference type="OMA" id="DLVWQIS"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF177">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER MCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="294"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="332"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="1"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF12835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="396" mass="42451" checksum="47913DC5BADB671D" modified="2013-05-01" version="1">MMACFGYMNTVGTYQAYLAMNQLSSYSESTIGWIFSVYIFLSFGAGVQVGPFFDKHGPFWLVVIGSICLLLSIMLLGVCSQYWHFMLVFGVLGGIGTAMIFTPAVSSVGHWFLRRRANATGIATCGGALGGVIFPLMLQDLFPKVGWAWATRIQGFIFILLLLVAILLLRARLPPRPGGSAWPDVSVFKDLPFALVTAGAYFLEWGLFIPVAYLTSYALDTDGAISPTFAYQLLAIFNAGSFFGRWVPGYVADKLGRFNTQIVAVFLCAASSLALWLPAAVYATSESSSSPQTILALTIVYAALMGFASGSNISLTPVCVGMLCPTKDYGRYIATTYTIVSLGCLTGLPIAGALISATGGSYWAVALFTGGCYICGLCCFVAVRVMKAGWKLAVIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M3D685</accession>
    <name>M3D685_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Diaminohydroxyphosphoribosylamino-pyrimidine deaminase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_148906</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761811.1">
        <property type="nucleotide sequence ID" value="XM_016905221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D685"/>
    <dbReference type="STRING" id="692275.M3D685"/>
    <dbReference type="GeneID" id="27902358"/>
    <dbReference type="eggNOG" id="KOG1018">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051532_1_1_1"/>
    <dbReference type="OMA" id="ACDTIYN"/>
    <dbReference type="OrthoDB" id="2529286at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF109">
        <property type="entry name" value="RIBOSOMAL LYSINE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF13690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="30868" checksum="66B4D126A9E6851B" modified="2013-05-01" version="1">MVGAQLQRAITGKSETFDLFSQSASMEDLGMLDPKKAVLEVTIAGRDFEITQSPGMLQSQRGGGTTGAAVWQSIVRFAEWLELSSNPLFRLGLLDATSVVLELGAGVSGILPCILSKRVHKVVSTDQAYTLKALQNNISTNLRETRVSAKVKTSLPAIEVLPLDWETDDALSFLRSAGLDSGVHMIVACDCIYNYALLAPFVQTCADLCRARCHPSNTNEDPKAATLCVIVQQLRQSEVFDQWLAIFRQRFRVWRVPSNLLSRGLQEGSGFAVHVGIVRQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M3D6N0</accession>
    <name>M3D6N0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase S54 rhomboid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_163217</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761650.1">
        <property type="nucleotide sequence ID" value="XM_016908039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D6N0"/>
    <dbReference type="STRING" id="692275.M3D6N0"/>
    <dbReference type="GeneID" id="27905176"/>
    <dbReference type="eggNOG" id="KOG4463">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057574_0_0_1"/>
    <dbReference type="OMA" id="RYRQFWR"/>
    <dbReference type="OrthoDB" id="272778at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066">
        <property type="entry name" value="RHOMBOID-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066:SF21">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF13529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="30190" checksum="B07415F6D55915A7" modified="2013-05-01" version="1">MHASGFANAPVTRVLVIATVVISFLATLTDTKYYAWIDIRPHLFDYHQFWRLFTWQLCYTNSTEVLFATMTLYNLRVIERLWSSRKFASFLVSTYIYNALIPPILLAAVIRPLSLGRINLPAGPTPMVFALLAQYHAAIPYIYKYRLSGSTTANAQDSSTTAGLMLTSKATSYLLPLQLALSQLPGSAITAAVGWAVGWAYRREILPGATRWRLPTWVLGGSEQKERYDNLRRRLEGEAGTATGVETNTDDRTRRRGVLGGLADQFRGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M3D714</accession>
    <name>M3D714_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Di-copper centre-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_125573</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762056.1">
        <property type="nucleotide sequence ID" value="XM_016901998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D714"/>
    <dbReference type="STRING" id="692275.M3D714"/>
    <dbReference type="GeneID" id="27899135"/>
    <dbReference type="eggNOG" id="ENOG502RM4B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035914_0_0_1"/>
    <dbReference type="OMA" id="PNDQYPG"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF126">
        <property type="entry name" value="TYROSINASE-LIKE PROTEIN TYR-1-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
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        <property type="entry name" value="Di-copper centre-containing domain"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="3">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF13935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="331" mass="37718" checksum="85D4A23E30D093B0" modified="2013-05-01" version="1">MARLMDRVHAGGDCTEDRIIVRKEWGDMSEDERRSFIDACKCLHNAPSQTPPDIAPGARNRWDDFVVAHLLHTYDVHRSPWLIPFHRELLFQLEKALRDECGYGGGLAYWDWPRYRDQPPEQWPMFDGSDTSLSGNGQANTPSEGCSCITDGPFADWKVNIGPVAGSHACTPNPQDDGLGFNERCLERQWDLTMLENLTYDNMLHSIQDMNEANTFNTYIEMWPLGLHTIPHMFVLGTQVDVPASPSDPWFFFHHSALDRASILWLYIDFDARVTTLPNADAYNDMRTLFQSPPAPAIGMDDQIQLSPIFEGVRVGDVLDPTNGRYCYRYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>M3D777</accession>
    <name>M3D777_SPHMS</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_115308</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016901149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D777"/>
    <dbReference type="GeneID" id="27898286"/>
    <dbReference type="HOGENOM" id="CLU_1982962_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF14015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="126" mass="13728" checksum="79AABA6CD2169649" modified="2013-05-01" version="1">MGHATADANGRTHVRAAMTPNITLRGKVHAVSTLNLRATSAHRGQVSQGGQVRVSFVQGSRRQPRYYIGCFAALLVPLAPERGNPIRTDINDGPGVIQTHWKAHKVQECDNVRYAYANHLLASMSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M3D7E7</accession>
    <name>M3D7E7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_116813</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016901286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D7E7"/>
    <dbReference type="GeneID" id="27898423"/>
    <dbReference type="HOGENOM" id="CLU_1107695_0_0_1"/>
    <dbReference type="OrthoDB" id="4132046at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032823" evidence="2">
        <location>
            <begin position="19"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF13799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="251" mass="26585" checksum="9CCA23B65B2EE8CB" modified="2013-05-01" version="1">MQCAIVALSALSIGSALAAPPTNVTSKPTDLVTVGLWHEAAESDTISLTIFKERHLPDSASPEQSYGPFDFVQLNLSSGVENKELRCQILDEFAEPIVLVRNGNVDITFSDQDKGAWILRDGEQDVFTVLCDPSFKSLNSPKTNSNSSSSSSFTTTRKSSTTSSAMKPSGWSGGYPSITKSWSDPSTFNSTLTKSTSSSSSKKSSSMSSPRANWTTSKATTSGSTSKSTSTSSCPASTIVVTSTITVSSKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M3D7I7</accession>
    <name>M3D7I7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_106510</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762266.1">
        <property type="nucleotide sequence ID" value="XM_016900641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D7I7"/>
    <dbReference type="STRING" id="692275.M3D7I7"/>
    <dbReference type="GeneID" id="27897778"/>
    <dbReference type="HOGENOM" id="CLU_900687_0_0_1"/>
    <dbReference type="OrthoDB" id="6270329at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="22"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF14145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="309" mass="34752" checksum="554A6C3AD28F6A8E" modified="2013-05-01" version="1">MPTLEQFVATGLTPVTEQSASCAICLEDPCVDPVTIACNHIFCHDCILTYSNAPTGNKCPLCRTILFTLPTPAPNPQIAERSALARALAPTYENSPPANTTDSDSTTGSEAEEENIYDTAHNFFENLSHRDGHGNVRMQVPDTTTTTTNPFGPPSPSTTASITTTPIIITGPGRWPSSPNLLCNRVKALGYLVRARQQITPGQGFSARLVSDWEEVLSDLDKILRKLCEKKKSRKVRKVSRLGKKLMRALKREWRKRHGRYAVWNAFLTQGRMHCVQVLLEFVEYLVWMEGRRMEREWEREGSTRCHFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M3D896</accession>
    <name>M3D896_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_132038</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762481.1">
        <property type="nucleotide sequence ID" value="XM_016902465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D896"/>
    <dbReference type="STRING" id="692275.M3D896"/>
    <dbReference type="GeneID" id="27899602"/>
    <dbReference type="eggNOG" id="ENOG502T1JF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028540_1_1_1"/>
    <dbReference type="OMA" id="LTWWDAI"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF46">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="54"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF14360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="624" mass="69932" checksum="CC1DB6F28C3C2E2D" modified="2013-05-01" version="1">MPRAIEKDDCFTCAANSRLCDRQLHRCRTCTDSSEVCRYPVSLRWRIEPSSRRKRPILGSRPRRVQSSSVKRSDTSEVSQTPISLSAINTPTETYSSSFDPIVPEEDTDSAVQDFPLWSALSEADEGQLMAAGSSVNDVSLNIANGISHPPPAVLDVSDCLITTTTTSTTNASANSLGEKSSGPSSLPAAASATHGWSPNAQFYQDANLTKPFEISSLLDLYRNQLCKIPVTHDFPANPFRCDTTPSLLSIHQTHAIVAITLQYLSRAPSPVSNQLWLRHVAKRERELACKGRKQSGGGGEAFCSSEFLDTLLVLVTLEHMCRGAGPWQGLILDVMSIVEGAGGISQMTRSPRRQAQLAMFVWWDITISLLSRQRGFLSQQYYDFVLGCECEEWNFEDLTGIPRSLVSALVEIVQLTQAQNRIVGMKWALFDDWRVREIERDLSDSASFLLPDLRIGDEVDTDEMIQHKHDRTACIQAWKFAVRLYIARVFPSSSGGGQQQQQHYHHQHSAKILSLARQTLDAARSCRSTSVMSKQLLFPIFLAGSETNDAYSRRYVEAYCKCWYAKTRYQLFPDTLQLLTTIWNLRDLGHGDDHETWWGSVLADLEDTTLYHGRLVRIHYLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M3D9G4</accession>
    <name>M3D9G4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">histidinol-phosphate transaminase</fullName>
            <ecNumber evidence="4">2.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Imidazole acetol-phosphate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_148211</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23744"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="2.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.9" evidence="4"/>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762640.1">
        <property type="nucleotide sequence ID" value="XM_016904777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D9G4"/>
    <dbReference type="STRING" id="692275.M3D9G4"/>
    <dbReference type="GeneID" id="27901914"/>
    <dbReference type="eggNOG" id="KOG0633">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_3_1_1"/>
    <dbReference type="OMA" id="NFVQFGR"/>
    <dbReference type="OrthoDB" id="2015537at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01023">
        <property type="entry name" value="HisC_aminotrans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005861">
        <property type="entry name" value="HisP_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01141">
        <property type="entry name" value="hisC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42885:SF2">
        <property type="entry name" value="HISTIDINOL-PHOSPHATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42885">
        <property type="entry name" value="HISTIDINOL-PHOSPHATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 13" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="9" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="12">
        <location>
            <begin position="64"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF14519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="425" mass="46609" checksum="3EFBE310491AFE0E" modified="2013-05-01" version="1">MPFDITKCARPNILALEPYRCARDDYKDDGTNILLDANENAYGPGLALTDDGKLVNGNTSGIEIDLLGLNRYPDPHQHELKQHLINLRNTHVHTEKNLTPENLFVGVGSDEAIDALLRAFCTPGKDKILTCPPTYGMYAVSAHVNDVGIVKVPLDVNNNFAAQPEKINEALSADPLIKMVYLCSPGNPTGSLVDKEAVRSVLEHPTWNGLVIVDEAYIDFAPEGSSLAEWVAEWPNLVVMQTLSKAFGLAGIRLGAAFTSPEVAKLLNSLKAPYNISNPTSQIAIQALQPKNLEVNYKHRGQIIQQRDRLLSEMPKIPGVGRFRGGTASNFLLVEMLDTSSKPNNEVALQVYERLAERRGVVVRFRGKEPGCLGCIRVTVGTEDEVTRFLKELKSVLEDVHAGRVSQNSKALEQQKEKDANGVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M3D9N4</accession>
    <name>M3D9N4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_148253</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762705.1">
        <property type="nucleotide sequence ID" value="XM_016904805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D9N4"/>
    <dbReference type="STRING" id="692275.M3D9N4"/>
    <dbReference type="GeneID" id="27901942"/>
    <dbReference type="eggNOG" id="KOG3764">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_51_3_1"/>
    <dbReference type="OMA" id="THDSMGQ"/>
    <dbReference type="OrthoDB" id="5086884at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17325">
        <property type="entry name" value="MFS_MdtG_SLC18_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF23">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        </source>
    </evidence>
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        <source>
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</entry>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
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                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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                <person name="de Wit P.J.G.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        <source>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Salamov A.A."/>
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                <person name="Kema G.H.J."/>
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                <person name="Scott J.A."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="EMBL" id="EMF15615.1"/>
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    </evidence>
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    </evidence>
    <sequence length="167" mass="19034" checksum="5EB79D06C00106FA" modified="2013-05-01" version="1">MSSFTGRELLLRGPHLAQFLYCLYGGALSYVAITNLRKYEATSKKLAEWSKEAETQLWKTRTTQASGALAILASFIGAFSLTFFPNALPRLMRMTTSPVLVVLVLFTRGHIKNYWAPKDGKNITRIPLPKMEDYNEAERRTENLLKALEYLEYSWVLTSFIHGMVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>M3DDG9</accession>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763985.1">
        <property type="nucleotide sequence ID" value="XM_016901876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DDG9"/>
    <dbReference type="GeneID" id="27899013"/>
    <dbReference type="HOGENOM" id="CLU_3130012_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF15864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="50" mass="5558" checksum="A7B879257AC4288C" modified="2013-05-01" version="1" fragment="single">MAREHYAESGCGCMRGISLQPGTRDVSASVSVKKHALVRPYYYGDNDYSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M3DE35</accession>
    <name>M3DE35_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7053 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_162072</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF16020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764141.1">
        <property type="nucleotide sequence ID" value="XM_016907978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DE35"/>
    <dbReference type="GeneID" id="27905115"/>
    <dbReference type="eggNOG" id="ENOG502R8N1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090697_0_0_1"/>
    <dbReference type="OMA" id="PDCRGCK"/>
    <dbReference type="OrthoDB" id="3838383at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055481">
        <property type="entry name" value="DUF7053"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38117:SF1">
        <property type="entry name" value="DUF3074 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38117">
        <property type="entry name" value="NACHT AND WD40 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23155">
        <property type="entry name" value="DUF7053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7053" evidence="2">
        <location>
            <begin position="5"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF16020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="222" mass="24290" checksum="1B31C7F80526B1A0" modified="2013-05-01" version="1">MWETSFQHASSTPLPPNVSIDTGLLLLRDFDCIVRLSPDCRGCHPIPAPPTSNGSSGANASNGTANGTSDNNITYYEVEDDLPFVPKRLWSGGVKYQADFLPTSDGCDITVHAPGGFTSTNRWRLLRGNEPAGRPSELEHEKDMDNVKSKTLLHADQTSSGWYVQIVSDATVNRAFANFVKGALRNSHQQLQHAFIEKLKGASEQPAGMQRPRLGRRKSSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDJ6</accession>
    <name>N1QDJ6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_135890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757632.1">
        <property type="nucleotide sequence ID" value="XM_016902740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QDJ6"/>
    <dbReference type="STRING" id="692275.N1QDJ6"/>
    <dbReference type="GeneID" id="27899877"/>
    <dbReference type="eggNOG" id="ENOG502SQ5Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049749_3_0_1"/>
    <dbReference type="OMA" id="HASSREM"/>
    <dbReference type="OrthoDB" id="3623237at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="303" mass="34447" checksum="BA656148CE2132CE" modified="2013-06-26" version="1">MARIIDSRSSKFDAFAKRYASGRRLPHSQLEFHLFKKALGDCTNYRVLDIAGGMGEYARHAIEAGASHIDVVDNRREMLQLGAKVEEESNEKNDKDDNHNNNNNNEKKKESENENTNNTNNETEKPPPTKKKPVKIHWHFAYNTLPLSLSLPPTILPPSSYDLIIAMWPWDHVATFQDYIHIWKNISYYLKPGGRLVAARMTNPWCEALQSGKYGAKCALIQQTEQRGVKVTVTVKTTPPFEVESEMTEASLRGETEVPEALGIGGLRSLEVAEVEIVKRDPVFWREFVEDPYFVVFEGRKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1QE46</accession>
    <name>N1QE46_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Vacuolar ATPase assembly integral membrane protein VMA21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_150648</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cytoplasmic vesicle</location>
            <location evidence="6">COPII-coated vesicle membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the VMA21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758722.1">
        <property type="nucleotide sequence ID" value="XM_016906311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QE46"/>
    <dbReference type="STRING" id="692275.N1QE46"/>
    <dbReference type="GeneID" id="27903448"/>
    <dbReference type="eggNOG" id="ENOG502SBNA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_154717_1_1_1"/>
    <dbReference type="OMA" id="AMKEDQT"/>
    <dbReference type="OrthoDB" id="160405at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03058">
        <property type="entry name" value="VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019013">
        <property type="entry name" value="Vma21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31792">
        <property type="entry name" value="VACUOLAR ATPASE ASSEMBLY INTEGRAL MEMBRANE PROTEIN VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31792:SF3">
        <property type="entry name" value="VACUOLAR ATPASE ASSEMBLY INTEGRAL MEMBRANE PROTEIN VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09446">
        <property type="entry name" value="VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="2 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF10601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="110" mass="11748" checksum="40DE159F1C63A417" modified="2013-06-26" version="1">MATRRVNTSAAKTPLNEDDTTLSPDVKSNISPAVPASVIYKLLGFTFAMITFPIGSYFLSVNLLFGGNSTYAGGLAALVANVVLIGYVVVAFNDDKSEREAAIEEEKKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1QEI3</accession>
    <name>N1QEI3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dynactin subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_150812</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758967.1">
        <property type="nucleotide sequence ID" value="XM_016906412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QEI3"/>
    <dbReference type="STRING" id="692275.N1QEI3"/>
    <dbReference type="GeneID" id="27903549"/>
    <dbReference type="eggNOG" id="KOG3958">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038287_0_0_1"/>
    <dbReference type="OMA" id="SDMDIQP"/>
    <dbReference type="OrthoDB" id="4977at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028133">
        <property type="entry name" value="Dynamitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15346">
        <property type="entry name" value="DYNACTIN SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04912">
        <property type="entry name" value="Dynamitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="293"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="359"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF10846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="424" mass="46388" checksum="71F1276762A4CA5B" modified="2013-06-26" version="1">MATAPVQRPGLPHLDTAPDVYETFPDDDTTASTAGNRSSPPLPSETDDTSADDDDDDDETGGVNTRRLFPSSARRRFGETSRAIETKGADLSDRVDGRRKGYRVKRSGGTRDDDETLEQKIARLRREVEECRAEAEAEKKERGEQQNGDGDEDHLDATEKLCDILAEAQLPEKAKRKKGHARNQSESVFHDAPTIAIPDTGADRDVPEGDEHTLARISVFDQRLAALETALGIASLHSVTDFDTTSTPFLPTLTLLDQQIASLTSAASLSSLEQATSRIQKLKTEAQNLAQLQKAAASTKDTTAGSNDEESEAPALLSSDDMKRLETLYSLLPGLQSLSPTVPALVTRLRSLRTLHTTAASASQDLDDIESRQAEMEKELKMWREGLQKVEGAVRRHGEDNGRNGSFVKGWVDDLEERVKALGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1QER6</accession>
    <name>N1QER6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_119460</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759071.1">
        <property type="nucleotide sequence ID" value="XM_016901512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QER6"/>
    <dbReference type="STRING" id="692275.N1QER6"/>
    <dbReference type="GeneID" id="27898649"/>
    <dbReference type="eggNOG" id="ENOG502S2ST">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_631882_0_0_1"/>
    <dbReference type="OrthoDB" id="291007at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110714" description="SH3 domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="161"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF10950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="434" mass="48089" checksum="4EF5259547FF558F" modified="2013-06-26" version="1">MKAVPLLIGAILILGAGLAYAHPHSQHIQRRTPWNSVHQAHYQHYKGQAWPCPGSRPGALQPCIIRWCFQNEESRVRLGQTVMAGIAHWKPAVEASWMRFAPAANTPTNLCTDPGVSLSAVRILHERTIVGGRSTLGYMPFSEDFLKKHHPDGIHLLEFNTLPPQVKAIKAFTPPPGQAPHEGALYFEVGTVLEVLHSTPVQGWVVGITVAGRRGIFPIDHVESTGLSLQYDAYVMAHELGHVAGLDHEHQRTDARAHFHFDCSQIHGYAEVKAAIDEKQKDLGYRNGDTIERVCEDSEMAKRYEDEIPEFAIAAWMPMDRSDVNGPQPKSVKTDFDSIMIYNSYNQNDYKRLAGKNYAFPQGAILTQIDPSAPSGRKEILGGGMKIDPATQGYDLSGVKVSEGDIARIAQLYPRDGVPGRAVAFKPEWQRAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFE6</accession>
    <name>N1QFE6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Derlin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_149820</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the derlin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760144.1">
        <property type="nucleotide sequence ID" value="XM_016905788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QFE6"/>
    <dbReference type="STRING" id="692275.N1QFE6"/>
    <dbReference type="GeneID" id="27902925"/>
    <dbReference type="eggNOG" id="KOG0858">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051898_1_0_1"/>
    <dbReference type="OMA" id="FKSQYWR"/>
    <dbReference type="OrthoDB" id="1716531at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007599">
        <property type="entry name" value="DER1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11009">
        <property type="entry name" value="DER1-LIKE PROTEIN, DERLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04511">
        <property type="entry name" value="DER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF12023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="250" mass="28322" checksum="68105335F67D8111" modified="2013-06-26" version="1">MAAIMGGGGEGGGAMPLEQWFFEMPVCTRWWTTATVATGILVQCQVLTPFQLFYSFRAVWQKQQFWRLITTFIYFGPLSLNLVFHIFFIQRYARMLEESAASAAHFSWMLAYTAVTLLAVAQPMFNQAFLASTLSSTLVYIWARRNPDTRLSFLGVLTFTAPWLPWVLIAFNVILHGHWPKDELCGVAVGHVVYFFNDIYPSTHHGHRPLDPPQWWVSLFERRVVPVAETDVHAAALNRDIAAPVVPDVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFL3</accession>
    <name>N1QFL3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_156888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760138.1">
        <property type="nucleotide sequence ID" value="XM_016907703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QFL3"/>
    <dbReference type="STRING" id="692275.N1QFL3"/>
    <dbReference type="GeneID" id="27904840"/>
    <dbReference type="eggNOG" id="KOG0668">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076146_0_0_1"/>
    <dbReference type="OMA" id="GQSTDIW"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF18">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF12017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="311" mass="34992" checksum="59E40B5762611253" modified="2013-06-26" version="1">MASSLRIGQLVKGVRDVYVVVQKLHNQVWSASATARNQVVLKCAPEMRIQREKEILQQFEGHSCLRSFIDHGKEPSPFLALEYLELDALKASGRAKLSRQDIKFIARSVLTALESLHAKGIAHTDIKPDNILLNFDAKSSRVVEAKLADCGDAWNVGLETDPRGTAHPIGAAIFRSPEALLGLKWSTPTDIWSFGATLISLIFGRNFHIFKPPNISADDEEFPVNVLIQQARYFGPFPLTYATYLDKEEEQVLAAIHILIEEQDSRKPFPLVEDKELTLGDKEFLCTVMELDPMERPTAKELLTHSWFNQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFP3</accession>
    <name>N1QFP3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_144162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757444.1">
        <property type="nucleotide sequence ID" value="XM_016903069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QFP3"/>
    <dbReference type="GeneID" id="27900206"/>
    <dbReference type="eggNOG" id="ENOG502S1N8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068116_2_0_1"/>
    <dbReference type="OMA" id="VWRSRED"/>
    <dbReference type="OrthoDB" id="2140489at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36986">
        <property type="entry name" value="UPF0643 PROTEIN PB2B2.08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36986:SF1">
        <property type="entry name" value="UPF0643 PROTEIN PB2B2.08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110280" evidence="1">
        <location>
            <begin position="18"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="217" mass="24586" checksum="AD5D17014C72F1F1" modified="2013-06-26" version="1">MTPCGLLLLLLLPQTKRDSVVTPSTIDLNASYLISSPYNHLANRLVLDDLEIPYRLFAFALTSLKPIRDDYATAPYLESFNWPDVFALLRDLCRQTGFAWKQLSFYTVIFRSVLLPGIDRGRLALLDQKSHEEACASGGLLKYWFGSTDAELKNLATCLWRSRQDAAAGGAGPWHAKARGAARTMYRDIDFYTHQLVVENGAESWRLDVHVEQRPHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFR4</accession>
    <name>N1QFR4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycosyltransferase family 32 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_149904</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760269.1">
        <property type="nucleotide sequence ID" value="XM_016905843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QFR4"/>
    <dbReference type="STRING" id="692275.N1QFR4"/>
    <dbReference type="GeneID" id="27902980"/>
    <dbReference type="eggNOG" id="ENOG502QS3D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036369_3_0_1"/>
    <dbReference type="OMA" id="NRHSWSF"/>
    <dbReference type="OrthoDB" id="3647at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051999">
        <property type="term" value="P:mannosyl-inositol phosphorylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.20:FF:000001">
        <property type="entry name" value="MIPC synthase subunit (SurA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051706">
        <property type="entry name" value="Glycosyltransferase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385">
        <property type="entry name" value="MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385:SF20">
        <property type="entry name" value="MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE CSH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF12148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="340" mass="39747" checksum="ED2906993C05CEEA" modified="2013-06-26" version="1">MRRPVLIFVVLILAVLAFLVHEVWTLLELLVINGIEDAITRAELPPIGAEHEIGATPIIPKIIHQTYINSSIPQVWQEAQQSCLDLHREPEWKYMLWTDAMSDAFIAKEYPEFLDTFRGYHYPIQRADAIRYFVLDHYGGIYIDLDDGCNRPLEPLLKYPAFVRKTIPTGVSNDAMGAVPGHPFFQRVIEELPHYDHSWILPYISVMASTGPLFVSIIWRHYSDEGFNVGDGPDGGRVRIIFPQEYQNQPWSFFTHHLGNSWHGYDVQLIFWMARNWVLVTMIGFVLGFGLIFLGWWYYNRYLLTPADVPRWKTKSIRQRLPFWSRRAQSEYELVNRHEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGV6</accession>
    <name>N1QGV6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GMF family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_71786</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the actin-binding proteins ADF family. GMF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757360.1">
        <property type="nucleotide sequence ID" value="XM_016909954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGV6"/>
    <dbReference type="STRING" id="692275.N1QGV6"/>
    <dbReference type="GeneID" id="27907091"/>
    <dbReference type="eggNOG" id="KOG1736">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087056_0_0_1"/>
    <dbReference type="OMA" id="EWKMLYA"/>
    <dbReference type="OrthoDB" id="3919494at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071846">
        <property type="term" value="P:actin filament debranching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034316">
        <property type="term" value="P:negative regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd11283">
        <property type="entry name" value="ADF_GMF-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000048">
        <property type="entry name" value="Putative gmf family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011171">
        <property type="entry name" value="GMF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11249:SF2">
        <property type="entry name" value="GLIA MATURATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11249">
        <property type="entry name" value="GLIAL FACTOR NATURATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001788">
        <property type="entry name" value="GMF-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="3">
        <location>
            <begin position="6"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR001788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF09239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="144" mass="16180" checksum="C8D65E4A8DACDF36" modified="2013-06-26" version="1">MSSESRLYTISPETKDKLRKFRLGTSRAKDPQAIIYQINKSNMEITPSDNPQVVYTNMLDLADELPDNTPRFILLSYPLTLSSGRLSVPYVMLNYLPPTCSAENRMLYAGAKELMRSTSEAGKLIEIDSAEDLEGIEEVLKGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGX3</accession>
    <name>N1QGX3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_127135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758519.1">
        <property type="nucleotide sequence ID" value="XM_016902125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGX3"/>
    <dbReference type="GeneID" id="27899262"/>
    <dbReference type="eggNOG" id="ENOG502SXI7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_190852_0_0_1"/>
    <dbReference type="OMA" id="RIVEAWC"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF10398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="86" mass="9965" checksum="9BEA43442B4F29B8" modified="2013-06-26" version="1">MCDYTKVEYACYHLRYTVRAWCVKYQETHKRCPANVVAVEYRLDERCGDCRDSPAPMYTLKKKASKLPNYKKDNGLSSSSSSSKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGY9</accession>
    <name>N1QGY9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_158509</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757395.1">
        <property type="nucleotide sequence ID" value="XM_016907795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGY9"/>
    <dbReference type="GeneID" id="27904932"/>
    <dbReference type="eggNOG" id="ENOG502QRFY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096561_0_0_1"/>
    <dbReference type="OMA" id="ADWMTKH"/>
    <dbReference type="OrthoDB" id="289247at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040250">
        <property type="entry name" value="Nucleobindin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19237">
        <property type="entry name" value="NUCLEOBINDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19237:SF20">
        <property type="entry name" value="NUCLEOBINDIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110806" description="EF-hand domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="91"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF09274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="205" mass="23858" checksum="A4B1BAEE4F1E5A01" modified="2013-06-26" version="1">MLYLVIAPVVIGLVHSVQAHGDNAHSAPPPVDPNADWATKHMAEEHHMASFDAGSFFNLHDYDSSNFWTADDLLKTYGLRHESTSHVAEEEKRASVQRVIDMFDRDKDNRISFAEYTIGVGQGLVLPDLGYGPGHHGDDEYEYEIHHWEKYHNENTKEEDLTHPEDIEHFRKHDEMEERELRQERMDKMAIIEANIPQKFRRKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1QHA7</accession>
    <name>N1QHA7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Aquaporin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_49530</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H2O(in) = H2O(out)</text>
            <dbReference type="Rhea" id="RHEA:29667"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758664.1">
        <property type="nucleotide sequence ID" value="XM_016909119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QHA7"/>
    <dbReference type="STRING" id="692275.N1QHA7"/>
    <dbReference type="GeneID" id="27906256"/>
    <dbReference type="eggNOG" id="KOG0223">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020019_1_4_1"/>
    <dbReference type="OMA" id="RAFLYWI"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1080.10:FF:000014">
        <property type="entry name" value="Aquaporin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF283">
        <property type="entry name" value="AQUAPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="211"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF10543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="265" mass="28694" checksum="4AEFAB8EE3DE978F" modified="2013-06-26" version="1">MLIDFVASLGEFMGTTMFLFFAFAGTQVANIGAGDNANQSTTNANTGFSPIVLMYISLSFGFSLMVNVWIFFRISGGLFNPAVTLGMIIVKGVGIVRGILLICSQLLGAIFGSFLVSVLFPTTFNVRTTLSEGTSIARGVFIEAILTAELVFTIYMLANEKHKATFMAPVGIGLALFIAELIGVYYTGGSLNPARSFGPCVISGIWDEEHWIYWVGPCVGACIAWAFYRVIKMLEYEMANPGQESASKEEAAEEAEEMTPKKETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>N1QHU6</accession>
    <name>N1QHU6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GPI anchored protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_119244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758834.1">
        <property type="nucleotide sequence ID" value="XM_016901492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QHU6"/>
    <dbReference type="GeneID" id="27898629"/>
    <dbReference type="HOGENOM" id="CLU_1251364_0_0_1"/>
    <dbReference type="OrthoDB" id="3650370at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110346" description="GPI anchored protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF10713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="221" mass="21374" checksum="F01739C44E9D4075" modified="2013-06-26" version="1">MQIIYNTALVAGLASTTAATSESACNTFSTTITSTVSTVTVTVSSAAEASPASASIMSSTAATSSSCATELSISSSTTANWTTTEQIAPSTTAWALSESQCISADKTVGVNTIPGFNGTSYVVCPGAAPYPTVSTIAPSGNATADAVGATHSSSFAFSPAGITNATTAAIGGATGTGAMAPTSVVAGPTVSIIPFSAGAAGIDNKDSFVALAGIAVAMIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1QI44</accession>
    <name>N1QI44_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_158759</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ELP4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757755.1">
        <property type="nucleotide sequence ID" value="XM_016907802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QI44"/>
    <dbReference type="STRING" id="692275.N1QI44"/>
    <dbReference type="GeneID" id="27904939"/>
    <dbReference type="eggNOG" id="KOG3949">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040685_0_0_1"/>
    <dbReference type="OMA" id="QGMLKVH"/>
    <dbReference type="OrthoDB" id="289162at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140018">
        <property type="term" value="P:regulation of cytoplasmic translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd19494">
        <property type="entry name" value="Elp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008728">
        <property type="entry name" value="Elongator_complex_protein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12896:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12896">
        <property type="entry name" value="PAX6 NEIGHBOR PROTEIN PAXNEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05625">
        <property type="entry name" value="PAXNEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="12"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="364"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF09634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="379" mass="40643" checksum="B33310945CF810B5" modified="2013-06-26" version="1">MAFRKRNIAVGRQNATAPGDAAPESIPGVRPSPLTSHPVTSTGTPSLDSLLGGHAGLAVGSSLLVEESGTTDFAGALLRYYAAEGICQGHVLHVVGMGEGWVRELPGVAEEKKSSRSVKSTADEEKMKIAWRYEKLGQAGERVLPVRTVGGSPNNVSQTVTPFCHTFDLTKRITIPSDARVNHIPVTPSTSLDSIVQALARSLATAPPNTVHRIVIPSLLSPALYSPLVGRPESFIGFFRSLRTLLRQHSNKLTAMLSLPLELYPRNSGLVRWAEILSDGVLELTPFPHLMDASNSLAESGGAREKDEQPQGLVRFHRLPINTERGEGGAGAGNSLGEDLAFTVSRRKFVITPFSLPPIEGDQEAQHDAGKVTAKDMQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1QI67</accession>
    <name>N1QI67_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_152996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765011.1">
        <property type="nucleotide sequence ID" value="XM_016907495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QI67"/>
    <dbReference type="STRING" id="692275.N1QI67"/>
    <dbReference type="GeneID" id="27904632"/>
    <dbReference type="eggNOG" id="ENOG502S5WX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058257_0_0_1"/>
    <dbReference type="OMA" id="NARAWYS"/>
    <dbReference type="OrthoDB" id="2306919at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF16890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="214" mass="23961" checksum="9BC3CE5936A7A4A3" modified="2013-06-26" version="1">MASIHAASPAIPFERLLARLKSFPAPVFNPGKAYDASLSDSIASQYLHPALEALMHLLNQDLASAHFLVRHMQAPPAYESMYVHGILHRIEGDYDNARAWYSNVSDWEGFTKFWGPPTDRPGEEAGQKVPRQQRARDFLDRIEKCAGSGGHQGEELESLQSESRAELESLLDWCLERLGTAMHKDATKDWVKPTEELKRMGEDQVSGSAGPRNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>N1QIH9</accession>
    <name>N1QIH9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SEPMUDRAFT_113015</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterohexamer; composed of 3 copies of TIM9 and 3 copies of TIM10, named soluble 70 kDa complex. Associates with the TIM22 complex, whose core is composed of TIM22 and TIM54. Interacts with the transmembrane regions of multi-pass transmembrane proteins in transit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion inner membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the small Tim family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765111.1">
        <property type="nucleotide sequence ID" value="XM_016901010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QIH9"/>
    <dbReference type="STRING" id="692275.N1QIH9"/>
    <dbReference type="GeneID" id="27898147"/>
    <dbReference type="eggNOG" id="KOG3479">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141397_3_0_1"/>
    <dbReference type="OMA" id="QDFLRMY"/>
    <dbReference type="OrthoDB" id="1551503at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.810:FF:000008">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit TIM9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050673">
        <property type="entry name" value="Mito_inner_translocase_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13172">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM9B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0143">Chaperone</keyword>
    <keyword evidence="10 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="14">
        <location>
            <begin position="16"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00064924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMF16990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="91" mass="10309" checksum="93A55A35D44E9137" modified="2013-06-26" version="1">MEGLNATEQRELQGRLEKKQMKDFMNMYSNLVQRCFTDCVTDFTSKSLSGKEEGCVMRCVDKSLKSAERLGERFQEQNASMAQQGGMGIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>N1QIN9</accession>
    <name>N1QIN9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_134167</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760405.1">
        <property type="nucleotide sequence ID" value="XM_016902615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QIN9"/>
    <dbReference type="GeneID" id="27899752"/>
    <dbReference type="eggNOG" id="ENOG502QWPB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019691_0_0_1"/>
    <dbReference type="OMA" id="CSCTMMH"/>
    <dbReference type="OrthoDB" id="4064873at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052478">
        <property type="entry name" value="Metabolite_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31779">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31779:SF4">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="37"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF12284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="603" mass="67249" checksum="107CD1CBE4BDE16E" modified="2013-06-26" version="1">MSTNGNHEAVGTKRSLSPDEDDSHATPQVGRQRSRVACTPCRVRKRRCDGRLPCATCVRYEYQCEYDQKAKRPSLPKDADVAAIPPPAPVVGSTAPSIIQLQKHPLTAPGARFHHRGILDPVKTRFVRANSAIAFPRILGMDLESDSIPRLHSFAWNLGIRAEPDEPPTNVTEHMTWAEFQTLSAAYFKFVKPQFGLLEEADFMEQVAPRFADPAGVKDIDCVALGVAALGSFFSATPHPKEVSFMFDARRVLVQRSVSNSPTPNHVAGWILRTIYLRLTSRPHGAWISSCITMHQVEAGGLHKEIQTIAVVYPQVPTNDHKLAKNRRRLFWIARALNTILSFEYGRTRVNFDVVTTKKFAPENGSQAHQFVELADLLPNDFVDRDREPDPPAALGKALDKIEAMQTESSFISLLKADLSFAIYRRLWLMSLTDAKDRADTVISIGKAALPAASKLLASRTPWWNVICTPFQLVCVVISVGTPRSLSHIQEIMNLMHNIARVYDTHMVREAYTQATALIAMAKKRKQKELDALNAIPENPPFPTDYPSTGQSSILSDAPNIDWAMDLPFEWDMFLNPELVVSSQQPMPPINTYANQFNPSQAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJ42</accession>
    <name>N1QJ42_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">acetyl-CoA C-acetyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_49789</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="4"/>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758715.1">
        <property type="nucleotide sequence ID" value="XM_016909132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJ42"/>
    <dbReference type="STRING" id="692275.N1QJ42"/>
    <dbReference type="GeneID" id="27906269"/>
    <dbReference type="eggNOG" id="KOG1390">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031026_0_0_1"/>
    <dbReference type="OMA" id="ICPSIAI"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000007">
        <property type="entry name" value="acetyl-CoA acetyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF165">
        <property type="entry name" value="ACETYL-COA ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="11">
        <location>
            <begin position="7"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="12">
        <location>
            <begin position="273"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="9">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="352"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF10594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="398" mass="41596" checksum="F20873766ABB04D7" modified="2013-06-26" version="1">MAPPKPVYILSATRTPVGAFQGSLSSQTAIQLGATAIKAAVERAGIKPEDVQEVFFGNVLQANLGQNPARQCTIFAGLPESTEATTINKVCASSIKAMSLAAATILTGEADVVVAGGTESMSNTPHYLQTLRNGAKFGDQTLVDGVLKDGLTDVYKNEHMGLQGEECADDHGFNREDQDEYAIRSYKKAIAAAESGFFKEEITPVTIKGTRGKPDTVIDQDDEPKKFNEEGTRKLRSAFKKDGTVTAANASPLSDGAAATVLASEEYVQKHGLKPIAKILGWGDAAQNPSKFTTAPALAVPKALKHAGIKQEDVDAFEINEAFSVVALANMKLLGVTEDKVNLHGGAVALGHPLGASGARIVSTLLGVLREKKGKVGVAGICNGGGGASAIVIERLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJ93</accession>
    <name>N1QJ93_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SsDNA binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_46970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759986.1">
        <property type="nucleotide sequence ID" value="XM_016909023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJ93"/>
    <dbReference type="STRING" id="692275.N1QJ93"/>
    <dbReference type="GeneID" id="27906160"/>
    <dbReference type="eggNOG" id="ENOG502S0M8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126647_0_0_1"/>
    <dbReference type="OMA" id="TQYVRKG"/>
    <dbReference type="OrthoDB" id="1078367at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF11865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="122" mass="13473" checksum="5A0575A855D6CC0B" modified="2013-06-26" version="1">MQAIRFQLPRAARAFSTTPARPLAKMQLIGRLADQPELTPTSTGRELVKYSLGVSTGPKDENGNRATSWFRVASFSDGPQRDFLLGLPKGSQIYLEADAAMNTYETAEGKRTTLNLVQRKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJF1</accession>
    <name>N1QJF1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">L-allo-threonine aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_32951</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine aldolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765446.1">
        <property type="nucleotide sequence ID" value="XM_016908521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJF1"/>
    <dbReference type="STRING" id="692275.N1QJF1"/>
    <dbReference type="GeneID" id="27905658"/>
    <dbReference type="eggNOG" id="KOG1368">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029381_1_0_1"/>
    <dbReference type="OMA" id="LVRIKAW"/>
    <dbReference type="OrthoDB" id="10261951at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008732">
        <property type="term" value="F:L-allo-threonine aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006545">
        <property type="term" value="P:glycine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06502">
        <property type="entry name" value="TA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000030">
        <property type="entry name" value="Low-specificity L-threonine aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023603">
        <property type="entry name" value="Low_specificity_L-TA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041359">
        <property type="entry name" value="GntG_guanitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097:SF9">
        <property type="entry name" value="L-THREONINE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097">
        <property type="entry name" value="L-THREONINE ALDOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017617">
        <property type="entry name" value="Thr_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aromatic amino acid beta-eliminating lyase/threonine aldolase" evidence="6">
        <location>
            <begin position="25"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR017617-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF17325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="373" mass="40170" checksum="E0964D9C37AF9AE6" modified="2013-06-26" version="1">MDSHATNGVKSNNYWCTESPISAFDFRSDTITTPNARMLEAITATTLADDVFQEDATTNDLEKLITLLTGKEAALFVLSGTMGNQVAIRTHLQGPPHSVVADHRAHIIEWEAGGVASLCGALCKGAIPSNGKYLTLEDVQKAVDLREDVHGCPTKLISLENTLGGVIYPVEEIRRISDWAHEHGIIMHLDGARLWEAVAAGAGSLADYCACFDSVSLCFSKGLGAPVGSMIVGTRAFRERARWIRKSIGGGIRQAGVLTAAARVAVEDTFLGGKLQACHERARQIAALWEGYGGRTSHAVETNMVWLDVEAAGITVDKFVELGQKAGVRLLGGRLVVHYQIGQAAIERLDNLFQAVLKHKELSGVSEAPNVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJF7</accession>
    <name>N1QJF7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RmlC-like cupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_159898</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764543.1">
        <property type="nucleotide sequence ID" value="XM_016907871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJF7"/>
    <dbReference type="GeneID" id="27905008"/>
    <dbReference type="eggNOG" id="ENOG502S4NI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090057_2_1_1"/>
    <dbReference type="OMA" id="ICASRMI"/>
    <dbReference type="OrthoDB" id="3511549at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="2">
        <location>
            <begin position="45"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF16422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="135" mass="14275" checksum="AD550109FE83B156" modified="2013-06-26" version="1">MPPQNPILVTPSSTLGSNSSGAQTQGMTRQNALVNVSSNICATRMIAAPHTASAIHHHGEENTIVFAFSGQGTIVSEGGTKKQVLMPGDFALIPAWAEHQEVNETDEEVVWAIVRSGREPVVVNLDEEGGWGSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJG0</accession>
    <name>N1QJG0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">4-hydroxyphenylpyruvate dioxygenase</fullName>
            <ecNumber evidence="8">1.13.11.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">4-hydroxyphenylpyruvic acid oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">SEPMUDRAFT_150714</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="22">Catalyzes the conversion of 4-hydroxyphenylpyruvic acid to homogentisic acid, one of the steps in tyrosine catabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>3-(4-hydroxyphenyl)pyruvate + O2 = homogentisate + CO2</text>
            <dbReference type="Rhea" id="RHEA:16189"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:36242"/>
            <dbReference type="EC" id="1.13.11.27"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:16190"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 3/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the 4HPPD family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.27" evidence="8"/>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758805.1">
        <property type="nucleotide sequence ID" value="XM_016906349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJG0"/>
    <dbReference type="STRING" id="692275.N1QJG0"/>
    <dbReference type="GeneID" id="27903486"/>
    <dbReference type="eggNOG" id="KOG0638">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034004_3_1_1"/>
    <dbReference type="OMA" id="DPFPVKG"/>
    <dbReference type="OrthoDB" id="414569at2759"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00362"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003868">
        <property type="term" value="F:4-hydroxyphenylpyruvate dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07250">
        <property type="entry name" value="HPPD_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08342">
        <property type="entry name" value="HPPD_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.180.10:FF:000020">
        <property type="entry name" value="4-hydroxyphenylpyruvate dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.180.10:FF:000022">
        <property type="entry name" value="4-hydroxyphenylpyruvate dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005956">
        <property type="entry name" value="4OHPhenylPyrv_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041735">
        <property type="entry name" value="4OHPhenylPyrv_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041736">
        <property type="entry name" value="4OHPhenylPyrv_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01263">
        <property type="entry name" value="4HPPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959">
        <property type="entry name" value="4-HYDROXYPHENYLPYRUVATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959:SF1">
        <property type="entry name" value="4-HYDROXYPHENYLPYRUVATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15 25" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="18" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="17" id="KW-0408">Iron</keyword>
    <keyword evidence="19" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="25" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <keyword evidence="14" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="VOC" evidence="24">
        <location>
            <begin position="119"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="24">
        <location>
            <begin position="297"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00018452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00029786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00033727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="EMF10684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="520" mass="58146" checksum="00CF0E7C0F34DF4D" modified="2013-06-26" version="1">MTGKRKESWVRVYKSPSTCTEQEHMKVWTWVHLGQHQQDLRCLNLHLLDHFRLPTNALSITHSSICLDNNCIPHTPRSTRYFKMAPGALIATTASGRTSPLYGTDTAAQAPPGQVEYRGYDHVTWWVSNAKQVAQFYITRMGFQPVAYKGLETGSRFIASHVVQNGDIRFVFTSPVRSSSRQTVKKALPEDQALLDEMHDHLDKHGDAVKDVAFEVDDVNAVYQSAISNGATSVSPPRVETSDSEGSVLLASIRTYGDTTHTFIQRSTYTGPFLPGYRPITLPEPTNSYLPPIHLSAIDHCVGNQDWNSMNSACEFYEQCLGFHRFWSVDDKEICTEYSALNSIVMSSSNGIVKMPINEPAVGKKKSQIEEYVDFYNGPGVQHIALRTGNIIDAVTNLRKRGVEFISVPESYYEDMYSRIIQAGATMTTAATTTKKNKESGGGGGGLQIKESWEKIRELNILIDFDAGGYLLQLFTKPLMDRPTVFLEVIQRENFDGFGAGNFRSLFEAIEREQEGRGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJJ8</accession>
    <name>N1QJJ8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SAGA-associated factor 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_130140</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the SGF11 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765501.1">
        <property type="nucleotide sequence ID" value="XM_016902340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJJ8"/>
    <dbReference type="STRING" id="692275.N1QJJ8"/>
    <dbReference type="GeneID" id="27899477"/>
    <dbReference type="eggNOG" id="ENOG502S8VT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_855242_0_0_1"/>
    <dbReference type="OMA" id="PGKEFCK"/>
    <dbReference type="OrthoDB" id="21557at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071819">
        <property type="term" value="C:DUBm complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013246">
        <property type="entry name" value="SAGA_su_Sgf11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051078">
        <property type="entry name" value="SGF11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46367">
        <property type="entry name" value="ATAXIN-7-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46367:SF1">
        <property type="entry name" value="ATAXIN-7-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08209">
        <property type="entry name" value="Sgf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="67"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="215"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="112"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="150"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="296"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="309"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU261113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF17380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="382" mass="41138" checksum="AA8A1B99D395917A" modified="2013-06-26" version="1">MTNAKEPSLATIAQKILEDALQQIVHNIVAHRHREHKMLVASLDTKTRLPHCDACNLPRLLDPPLASRVRGTAADPPSNTNYCDRKPWAKRPGHDIYGNPFLKSDVTGRPLTKKEREAQKNNKKDDGTPASEDQTHEGTGPPSPNGEAEDDKKAGNNQKLEKGEKKASKIDEKLKKGEYVPWHTCPSCKRSLLITRFAKHLEQCMGLSGRAASRNAMAKMNGTPSGSRGGTPNPGQEGNGKEGAGDGEDGDSAVKGAGGVRKKLLKKGLKEKAKANKTANGKLPKSLAAQRPPAGGKDKDKDKDKDASTTRSSPAPSSIGDAKRDREELGEDDESEVLHVKKRQKLQRMGSTTSIVSAVTAPDMERGESQDGSFVDGSVVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJM5</accession>
    <name>N1QJM5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycerate mutase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_36394</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765557.1">
        <property type="nucleotide sequence ID" value="XM_016908637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJM5"/>
    <dbReference type="GeneID" id="27905774"/>
    <dbReference type="eggNOG" id="KOG4754">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039184_1_1_1"/>
    <dbReference type="OMA" id="HGCFLHF"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF54">
        <property type="entry name" value="PHOSPHATASE SPAC5H10.03-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF17436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="191" mass="21797" checksum="C07CD2636CA5B2BF" modified="2013-06-26" version="1">MPPILHLVRHAQGLHNVSTSNHILHDPDLTALGEQQCSDLRRRGSPSSFPHQQIDLVVASPMKRTIRTALLAFGETILEPKSLQVVCLPELQETSDLPCDTGSTREELEGLFRGQAVDLQYVTPGWDRKIGRWAPDREAVQARARQARVWLKNRPEKEIVCVTHGDFLHYFMEDWSEVDRTGWANAEYVFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1QK72</accession>
    <name>N1QK72_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutaredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_146575</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaredoxin family. Monothiol subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765716.1">
        <property type="nucleotide sequence ID" value="XM_016903741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QK72"/>
    <dbReference type="STRING" id="692275.N1QK72"/>
    <dbReference type="GeneID" id="27900878"/>
    <dbReference type="eggNOG" id="KOG1752">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026126_0_0_1"/>
    <dbReference type="OrthoDB" id="423313at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005796">
        <property type="term" value="C:Golgi lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03419">
        <property type="entry name" value="GRX_GRXh_1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000093">
        <property type="entry name" value="Glutaredoxin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011899">
        <property type="entry name" value="Glutaredoxin_euk/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02180">
        <property type="entry name" value="GRX_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694:SF5">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaredoxin" evidence="4">
        <location>
            <begin position="191"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="103"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="103"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF17595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="298" mass="32875" checksum="1C5478952ABDA34D" modified="2013-06-26" version="1">MPSTRQFRSIGLLTVLAFCIIYYIYNGASDTHESEFYQRTKAALERKKTSHDRDQIFAEEKDRLGRVERLRKEHDAAVEKEGATKVSTSHSEAAVTQVVGGEERIKGQKPLKVPDTEKDGKVVHGAPEKDSDDGVAKIGNVRQQQQSLHKEGGAVTEGEDDDEDAAAKRKKKQEEAEVEAELTDILKKGPIIVFSKSYCPYSKKAKHVLLDLYSITPAPYVVELDTHPLGPGLQSHLYKSTGRRTVPNVLINGRSIGGGDDIVGLHESGKLIDTITSMGGKRIMSASKKEPHAKRFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKI8</accession>
    <name>N1QKI8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolase family 128 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_146642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765811.1">
        <property type="nucleotide sequence ID" value="XM_016903785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QKI8"/>
    <dbReference type="STRING" id="692275.N1QKI8"/>
    <dbReference type="GeneID" id="27900922"/>
    <dbReference type="eggNOG" id="ENOG502S8FM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040908_6_2_1"/>
    <dbReference type="OMA" id="WLNEFAC"/>
    <dbReference type="OrthoDB" id="43654at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071966">
        <property type="term" value="P:fungal-type cell wall polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053183">
        <property type="entry name" value="ASL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024655">
        <property type="entry name" value="Asl1_glyco_hydro_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154:SF3">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11790">
        <property type="entry name" value="Glyco_hydro_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asl1-like glycosyl hydrolase catalytic" evidence="1">
        <location>
            <begin position="12"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF17690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="250" mass="28325" checksum="75A63D86D72B8C21" modified="2013-06-26" version="1">MSACTRPATKRGLCWPVENKDPIFTFTKPGSKISWIYNWSPNVLTPSSLQFIPMQWNNANIEELSKKVQEAQAPALLAFNEPELPDQSNMSAELAANEWLRCIEPIRKAGVRCGSPGISNAGHAVGYLQDFLARIRAGGSDIDFYCIHWYGETLGQFYDYIWSTYHQLGPNKPVWITEYAATNWNQDAPLPRDHVESFAKESAKYLDTLEWVERYCWFGPMRDTGTVGKHAAMFDAEGKLTSLGKAYRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKJ6</accession>
    <name>N1QKJ6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_21778</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765897.1">
        <property type="nucleotide sequence ID" value="XM_016908341.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QKJ6"/>
    <dbReference type="STRING" id="692275.N1QKJ6"/>
    <dbReference type="GeneID" id="27905478"/>
    <dbReference type="eggNOG" id="KOG1200">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_1"/>
    <dbReference type="OMA" id="ELWYDVI"/>
    <dbReference type="OrthoDB" id="2117591at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF83">
        <property type="entry name" value="(3R)-3-HYDROXYACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF17776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="270" mass="28136" checksum="8DF779EE024EB9EC" modified="2013-06-26" version="1" fragment="single">FQGKTCLITGAASGIGRATAIKMASMGATLALSDINLPGVLETQSLCANSSTHIASLLDVSSSSAISEYFTGEIIPHLQLQTTSTSTSTSNPEGEGKGEEKRKSLDYIFNCAGINPTAYPLTTTSDTYWDKLINTNLKGTYLISRAAIPLLSSSSSPSIVNVSSTMGLQAAPEYAIYCATKFGIVGFTKALALELGPQGIRVNAVAPGYIDTPSNAGVVAGPEAVQEQVDRVALGRMGTAEEVADVVAFLFSEESRYMTGAVVEITGGRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1QL14</accession>
    <name>N1QL14_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_146095</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Clathrin-coated vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765103.1">
        <property type="nucleotide sequence ID" value="XM_016903453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QL14"/>
    <dbReference type="STRING" id="692275.N1QL14"/>
    <dbReference type="GeneID" id="27900590"/>
    <dbReference type="eggNOG" id="KOG0934">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061221_0_0_1"/>
    <dbReference type="OMA" id="KAYHILD"/>
    <dbReference type="OrthoDB" id="371463at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048203">
        <property type="term" value="P:vesicle targeting, trans-Golgi to endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd14831">
        <property type="entry name" value="AP1_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000007">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044733">
        <property type="entry name" value="AP1_sigma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="10">
        <location>
            <begin position="3"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF16982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="156" mass="18186" checksum="A21080C29A1B678D" modified="2013-06-26" version="1">MAIRYLILLSRQGKVRLAKWFTTLSPKDKAKIIKDVSQLVLARRARMCNFLEYKDTKVVYRRYASLFFIAATDPTDNELITLEIVHRYVEQMDKYYGNVCELDIIFNFQKAYFILDELLLAGEMQESSKKNVLRVIGAQDSLEDMEVEDDSVTRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1QL74</accession>
    <name>N1QL74_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_146146</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765158.1">
        <property type="nucleotide sequence ID" value="XM_016903478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QL74"/>
    <dbReference type="STRING" id="692275.N1QL74"/>
    <dbReference type="GeneID" id="27900615"/>
    <dbReference type="eggNOG" id="ENOG502S9XT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021861_1_0_1"/>
    <dbReference type="OMA" id="QWPSMLT"/>
    <dbReference type="OrthoDB" id="9909311at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF70">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04218">
        <property type="entry name" value="CENP-B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="4">
        <location>
            <begin position="182"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="258"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="269"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="342"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="406"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF17037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="531" mass="57593" checksum="17F2AA9F272BE195" modified="2013-06-26" version="1">MTVDAMADDERNTAYRSSPPSNWNHFPIHPHSHHGTPAQEYQGFSFASPQLPMEPSAFASGVQQRSMHHHLQPLVMPQWPSMLSSQAHAPYQSMYQQPMQTMHPVSTGPLMTPLSATSTKSTSTPRKTLTDLDRKRMCQYAEEHPNSKQTEIGAIFGVERSTVSKVLRQKEKFLFQDDGSRSPVKRAKGRSPDIERALAVWAKNQEKKGNPLSDDLIRAQARAFAATTSSPDHLVSLSSSWIGKFKLKNNLLGARSRKTSLVPDDPDHPAAASSSSHTPGDLSPTSPSAPGSPSPIDLQSAQSYESQKRGSPDDYFDFASNRNGPHHAQSTTSLHSAYTENGPSSFSPGPLSPTTSPFFTPDSGTAPSPFVPPSLQARPILVGPSSAANSHRPRSQTFPCLEPAYVSSSGDATTPKYSTSSDLNASTQGPLDALTSLDEAMSMHDSESRPPTVTPLDTMRPPPLPAHAARRESGLAPGLAQGITPEEARQALRVVLRFIEQHGVVDYHETLTMGTLMEKLKLQQPPARAHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1QLH0</accession>
    <name>N1QLH0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">pyridoxal 5'-phosphate synthase (glutamine hydrolyzing)</fullName>
            <ecNumber evidence="3">4.3.3.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_156937</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by PDX2. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Also plays an indirect role in resistance to singlet oxygen-generating photosensitizers.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + phosphate + 3 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="4.3.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the PdxS/SNZ family.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.6" evidence="3"/>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760202.1">
        <property type="nucleotide sequence ID" value="XM_016907705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QLH0"/>
    <dbReference type="STRING" id="692275.N1QLH0"/>
    <dbReference type="GeneID" id="27904842"/>
    <dbReference type="eggNOG" id="KOG1606">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055352_1_0_1"/>
    <dbReference type="OMA" id="RYANRGW"/>
    <dbReference type="OrthoDB" id="1660966at2759"/>
    <dbReference type="UniPathway" id="UPA00245"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036381">
        <property type="term" value="F:pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04727">
        <property type="entry name" value="pdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000001">
        <property type="entry name" value="Pyridoxine biosynthesis protein PDX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01824">
        <property type="entry name" value="PdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001852">
        <property type="entry name" value="PdxS/SNZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033755">
        <property type="entry name" value="PdxS/SNZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003215">
        <property type="entry name" value="PRK04180.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00343">
        <property type="entry name" value="pyridoxal 5'-phosphate synthase lyase subunit PdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNZ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829:SF0">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNZ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01680">
        <property type="entry name" value="SOR_SNZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029271">
        <property type="entry name" value="Pdx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01235">
        <property type="entry name" value="PDXS_SNZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51129">
        <property type="entry name" value="PDXS_SNZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0704">Schiff base</keyword>
    <feature type="domain" description="PdxS/SNZ N-terminal" evidence="12">
        <location>
            <begin position="39"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with D-ribose 5-phosphate" evidence="9">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR029271-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF12081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="326" mass="34373" checksum="09003C89053AAB55" modified="2013-06-26" version="1">MAINDTPTNGNTHPITAASKTNTTNITSQSNAADPQSSFAVKVGLAQMLKGGVIMDVVDAEQARIAEEAGAVAVMALERVPADIRKDGGVARMSDPAMIKDIMKAVTIPVMAKARIGHFVECQILQAIGVDYIDESEVLTPADPVNHVDKSVYTAPFVCGCRNLGEALRRISEGAAMIRTKGEAGTGDVIEAVRHMSTVNAEIAKASSMSDADLRMMARELECDYALLKQTAQLKRLPVVNFAAGGIATPADAALMMQMGCDGVFVGSGIFKSGDAAKRAKAIVQATTHFNDPKVLAEVSSGLGEAMVGINCDKLPEQQKLAKRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1QLS2</accession>
    <name>N1QLS2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Telomere-associated protein Rif1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_122224</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764869.1">
        <property type="nucleotide sequence ID" value="XM_016901756.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.N1QLS2"/>
    <dbReference type="GeneID" id="27898893"/>
    <dbReference type="eggNOG" id="ENOG502QSZW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000830_1_0_1"/>
    <dbReference type="OMA" id="FMTPPHL"/>
    <dbReference type="OrthoDB" id="1659429at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140445">
        <property type="term" value="C:chromosome, telomeric repeat region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022031">
        <property type="entry name" value="Rif1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22928">
        <property type="entry name" value="TELOMERE-ASSOCIATED PROTEIN RIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22928:SF3">
        <property type="entry name" value="TELOMERE-ASSOCIATED PROTEIN RIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12231">
        <property type="entry name" value="Rif1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="Telomere-associated protein Rif1 N-terminal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="993"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1136"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1251"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1344"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="995"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1160"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1251"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1366"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1388"/>
            <end position="1401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF16748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1493" mass="165769" checksum="2DE361986DA14D1E" modified="2013-06-26" version="1">MALTGAIKSYSRVPDAQSLAEKMARLTQCLSRDLAWKDPTGHLDVQVVQMALSLTCAILFDPQTQDLFDLDFHAFVIDRSIFVLEQAGMAKGVVKGHLHLLCVQRFPRAAFGGGRAERLIHVMQNLEARNSMVAARLVIYQRLIERAPTTMLNRVKDWIEHIFHALLSSVNDVQRRAIDVCTQMGMLLGHHPQVAKAISELCEKELEEGQCYGDYLNMQLLQMTSDKVKAPLVPEIWVAVIMCFRSKRCPVGKWPKFRDWLLTIQKCLNSSDMAVKRPANIAWNRLVYAVMPDSSTSELLRSMLKVPVLAGLERRGCSELSQQLRQLSLDSYCNLIHYAMRPELAHEELDIAWDMYVGPVLTKISTGSKGRNTAFRVLHGLLKKTDGTWNANAANERNPIQPDDLPSLDVRWVRSRMARFMAVMEPLTLSQLSMTLDTQHAMDNCWRSLITAVADAGSQEVKASNELKDAIALIVNFLHRLWKSGAAFTAEDDSQRWLNRYQNMLENAVVSLGSLHFVDDILVKTSADDIEAAPTPSHRQPKQQPMTCSPFVLLFGLYYEPPLALRASGVMQKSAVWFLRLLAGAKISTSALLGLLQRSLQNKTDNLSPELEHIYGQLWTAVADMATQTLKMQSSVSPQRDTFVMGVALKATTSIILSGLRYREADCQQKVVQMYNAACHSARHVASDGGIVLAVMEPLARLIVEQSSQLSMVSILRLASTIAESGVWPSTRSELDESRKALWTVSLEPCKMQVFDPFDHVYSFFSYTLESSYQSLADFKGGEEKLVSMLMSSLASFLQRCPPTLFQTALDKLQRGYATWAEDHQGFVFPSGDVPRTEDEQSEKTRTLQLGINESWSQLLSLVTEKLSIPKGLLLDVLEPLLIAGFSSRSNSIVNATIGFWNSTFAKQQQLDYPVKLSPVLRARQIQSDLTIPEFPRLRDDVRSAGLPVCGGSQAPAIVDRRHLVSGNRATPLHHKRSSDNFFIKQHLAAQCLPSESRSNSSESSETTTRPKTDDSQAHFTPVEPLSSTTNPEPQLWTARQQEVRARQRDDAQAYAWLPSSPLAPPSVSREHIPQKLKFVSDLRRTETGDIVITPKGARDVALFNDDIQSSPTPSRGKESVSSTADCTVEIDEYSELHSSPPELATGGSSSAVMPAAQAGISSSEHFSSHNATVNESTNVEMAVADSDLPSDTQLPSAQLQLEEEAAVSLYDTDLETRMTHVREYGTPKKVPVSPETPSRIEDTILNSRNHIISTPSDTGTTDSKVSRSSRKRKRTAETAHIARKRKPASPFNTFMSLFSNAQEEQIGEEIVVATNPSASSPHTEAVHLTPVTLENALEHDGKAIATLPEGPSNEGVTKRKRGRPRKSESQDMERLVSAQTRGRKRASSALSADGSSGDTSSQRKQRRRVAHQADQEAKKGAMAPAHITAVDEQTASPQLEARQMAQPQSILGRLRGLLADCKNMILGSQEEEREFDDVLFEIRREVHQRAQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1QM49</accession>
    <name>N1QM49_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha N-terminal protein methyltransferase 1</fullName>
            <ecNumber evidence="5">2.1.1.244</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">X-Pro-Lys N-terminal protein methyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_77499</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54712"/>
            <dbReference type="Rhea" id="RHEA-COMP:13785"/>
            <dbReference type="Rhea" id="RHEA-COMP:13971"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138057"/>
            <dbReference type="ChEBI" id="CHEBI:138315"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-methionine = N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54736"/>
            <dbReference type="Rhea" id="RHEA-COMP:13787"/>
            <dbReference type="Rhea" id="RHEA-COMP:13974"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138059"/>
            <dbReference type="ChEBI" id="CHEBI:138318"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54724"/>
            <dbReference type="Rhea" id="RHEA-COMP:13789"/>
            <dbReference type="Rhea" id="RHEA-COMP:13973"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138061"/>
            <dbReference type="ChEBI" id="CHEBI:138317"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. NTM1 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.244" evidence="5"/>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765463.1">
        <property type="nucleotide sequence ID" value="XM_016910163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QM49"/>
    <dbReference type="STRING" id="692275.N1QM49"/>
    <dbReference type="GeneID" id="27907300"/>
    <dbReference type="eggNOG" id="KOG3178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055356_2_1_1"/>
    <dbReference type="OMA" id="PVRMYCL"/>
    <dbReference type="OrthoDB" id="1298661at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071885">
        <property type="term" value="F:N-terminal protein N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008576">
        <property type="entry name" value="MeTrfase_NTM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12753">
        <property type="entry name" value="AD-003 - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12753:SF0">
        <property type="entry name" value="ALPHA N-TERMINAL PROTEIN METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05891">
        <property type="entry name" value="Methyltransf_PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016958">
        <property type="entry name" value="DUF858_MeTrfase_lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR016958-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF17342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="241" mass="26908" checksum="7D3CBD8E06E24B82" modified="2013-06-26" version="1">MDMDTDVEDTVVKTETARSNADAQINHEAAIAYWSSQPASDDGVLGGHAEVSRVDLQGSANFLAKLRRTSTEFPPSKGKLQRVADTGAGIGRITKGFLSNVALTVDIVEPVTKFTASLATEAYVGKIYNCGLEDWTPETSYDLIWNQWCVGQIRDDQLVEYLKRITAHLNPGGWIIVKENITNNILGENEYDETDSSVTRTDLHFRQIWDRADLRLVSTELQKGFPKILYPVRSYALQPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1QN16</accession>
    <name>N1QN16_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61</fullName>
            <ecNumber evidence="1">2.1.1.220</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">tRNA(m1A58)-methyltransferase subunit TRM61</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_146093</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.220" evidence="1"/>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765100.1">
        <property type="nucleotide sequence ID" value="XM_016903452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QN16"/>
    <dbReference type="STRING" id="692275.N1QN16"/>
    <dbReference type="GeneID" id="27900589"/>
    <dbReference type="eggNOG" id="KOG2915">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029873_1_0_1"/>
    <dbReference type="OMA" id="FYVGHVE"/>
    <dbReference type="OrthoDB" id="5585464at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160107">
        <property type="term" value="F:tRNA (adenine(58)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049470">
        <property type="entry name" value="TRM61_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133:SF1">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08704">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 C-terminal" evidence="9">
        <location>
            <begin position="132"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="323"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="335"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF16979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="386" mass="42788" checksum="73A43939FCDB97F1" modified="2013-06-26" version="1">MRLLRGSPSSAATLSRSALHQITTSACWTRTSTRRRLFSDRPFQADDLVLLRNKNDRTAPPILSKPLKPGRRIESHRGVVLHDDLIGRRVRDVVRAQTPRSTKGTVGAEYRLHQVTLDDYCRLSRRLVTPIYPADANVICSLLNLHPSSPGTEGDDPIEILEAGTGHGALTMYLSRAIWNSHAVLHTIEISPKFSAHAQDVISAFRGGIYAQNVKFHVGDVSEWIAEEKCSRGADGEPFLAHAFLDLPNADAHVETLAGALQIDGMLIVFTPSISQITELAMKIKDQGIQLDLEKVIELGVNGSSGGREWDVRFVRTRAEQRKEIEQEELATTEDSQHSGHEPRDAESAPVHAEAVKWSSICRPKVGDRIIGGGFLGVWRKQRDMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1QN94</accession>
    <name>N1QN94_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Exocyst complex component Sec10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_146860</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016766088.1">
        <property type="nucleotide sequence ID" value="XM_016903915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QN94"/>
    <dbReference type="STRING" id="692275.N1QN94"/>
    <dbReference type="GeneID" id="27901052"/>
    <dbReference type="eggNOG" id="KOG3745">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008002_1_0_1"/>
    <dbReference type="OMA" id="PLCKHHY"/>
    <dbReference type="OrthoDB" id="125856at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009976">
        <property type="entry name" value="Sec10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048627">
        <property type="entry name" value="Sec10_HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048625">
        <property type="entry name" value="Sec10_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100">
        <property type="entry name" value="SEC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07393">
        <property type="entry name" value="Sec10_HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20667">
        <property type="entry name" value="Sec10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec10 N-terminal" evidence="8">
        <location>
            <begin position="79"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex component Sec10-like alpha-helical bundle" evidence="7">
        <location>
            <begin position="207"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="224"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="83"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF17967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="880" mass="98545" checksum="332D5547375B59B5" modified="2013-06-26" version="1">MSRVDSPDTASIISAHSSRAPTLQSVRGNQVFTLDTFSSKDFIVKDFVESLSDSATSARRSASTAATTNNAQTSQAFDPKPLIRTFEHALNKLKNLSEDLQERENELSASVRKAEVQHNTNIRSREQELERAIGSFRRLERTLDGDGDAGGNAAMRIGERLDELDKQRQRAQDAKFVLQCWLEVSERGDLSSLDDVRKMGGGEGKVRCAHIARQLLKISQRLDGSTEAPKTNGTHFTDGVNGIHDNDSTDSIRKPNNGAKPREIIEKFLEMLEKDLLKSFDDFYRRQNFEGMRECAVALQDFSDGNSVISLFVNQHQFFIDGSQLVNEELAVDNETWDRLADPDTEPPGVEPSLQSLIDEVKVVVQEESFIIKRAFPYYEDVLARFIQRVFQQSIQQRLEMVLEKADSISSLAFLRSLQASRSYIAALVEELKIHGLTEHPEPATSTTAAVLDQQLDELFVPYFTGASYIEREKRNLGEIFEGLLFKFTLYHSRRRKVHVQSHTYLGAISARGKEFISSARDAYMERLDSADLQPAQKKMLLRVAGLHHTKDHTGANDIDVTDEDGQLSLPSTKRMLKWLAEGVGRELELASGGNETPKEVRELLHLLITHMGEIYLETALDAANDSAAAAEANTKTEPDLNYIADLRSAISVLHLMLTTIQMLLLPLAASNLTIRRELEKQTSNFVDRMELKIDTVLQRTLDASLAWTQKVLSGQKRTDYRPKDELNLQLEFQTSTCHAVFTFLSRLHSRAKTALQSSGKVLEAFSLELAIGLRGLLLQHFKSYQISQTGALLASKDITKYIELLRSWDLPASFDPSFEVLTEIANLFVIGPEALRDRLRNFGVGVAGLQGVEKGDLRAYILRREDSGSVGVQTVLNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNE3</accession>
    <name>N1QNE3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_146638</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765804.1">
        <property type="nucleotide sequence ID" value="XM_016903783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNE3"/>
    <dbReference type="STRING" id="692275.N1QNE3"/>
    <dbReference type="GeneID" id="27900920"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_19_5_1"/>
    <dbReference type="OMA" id="IHSKTRM"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF309">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="11"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF17683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="426" mass="47268" checksum="0A1BCF6FAA42BAB1" modified="2013-06-26" version="1">MATNPSSSGLDVLILGGGIAGLTTALALTKYAPKDQVPRIRIFEIRPEPATIGGAVNLTPNALRMLDHLGALPIIRERNYGRDIDVLEIFDVYSGKIAESSFRGPDGKGVGNPPYKALRITRGDALKGVLAAIEQQKNITITCGKRTVKIDETEEKVTLHFEDGESVSGDLLMGCDGIHSVTRLKHVEPERKATYSGVSNAFGFAKVDPDFKVHFSCTAINFARRGMLLTSFHSPATDSIYVGGLMQVEDIGSRDGWKSVGADAERTRAQLLERFADAQIPSIKPLIEQAKDFYLWPVFTLSKQGKWSTNRVMLLGDAAHAMPPQGESTGIVFEDTVLFSRCLTRWIEKGKPNTMKEPFEAYEKLRRPRIDVAFEESKTVVKTVSDAGWLGHKIKTFIVPWYLWFTKNYREAHFIEDVTRADLGYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNP8</accession>
    <name>N1QNP8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-superfamily hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_146851</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016766074.1">
        <property type="nucleotide sequence ID" value="XM_016903907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNP8"/>
    <dbReference type="STRING" id="692275.N1QNP8"/>
    <dbReference type="GeneID" id="27901044"/>
    <dbReference type="eggNOG" id="KOG1618">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030880_3_1_1"/>
    <dbReference type="OMA" id="RDWASDQ"/>
    <dbReference type="OrthoDB" id="10251048at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000069">
        <property type="entry name" value="HAD-superfamily subfamily IIA hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006353">
        <property type="entry name" value="HAD-SF_hydro_IIA_CECR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01456">
        <property type="entry name" value="CECR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF4">
        <property type="entry name" value="CAT EYE SYNDROME CRITICAL REGION PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF17953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="452" mass="50173" checksum="65E6B3B2269EB565" modified="2013-06-26" version="1">MSGPVLPKRPTRTFRRVSSSDVTLNALSLRSPTVVVPPKHLMAPSNAQETAMAFELARHEIEDATTPFSAPATPPETTVTDKFAFAFDIDGVLIRGGRPIPEAVEAMQVLNGKNEYGVKIPYIFVTNGGGKTEQERCIQLSQQLELEVSPGQFICGHTPMREMAEKYKTVLVVGGEGEKCRQVAEGYGFKDVVTPGDIIKDNPDTTPFRKLTEEEYNNSRTRNFADVEIEAIFVFADSRDWAGDQQIILDLLMSKKGVLGTRSETFDEGPPVFFSHNDVIWSASHDLTRLGMGALRLSLEAMFKAVTGKDLKTTAFGKPQGGTFEFATRLLQQWRRDTHGIDAAPETVYFVGDTPESDIRGTNEYNENSKQEWYSILVETGVYEAGTKPRYVPRATVKTVLDAVNHGIDRENKRQQKVLMKDALNISDLKLNGSAVDESQDHDFRMVETIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNT5</accession>
    <name>N1QNT5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase M20 domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_146562</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765700.1">
        <property type="nucleotide sequence ID" value="XM_016903732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNT5"/>
    <dbReference type="GeneID" id="27900869"/>
    <dbReference type="eggNOG" id="ENOG502QQPD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031812_1_1_1"/>
    <dbReference type="OMA" id="LWPINKK"/>
    <dbReference type="OrthoDB" id="6119954at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05672">
        <property type="entry name" value="M20_ACY1L2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.360:FF:000004">
        <property type="entry name" value="Peptidase M20 domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052030">
        <property type="entry name" value="Peptidase_M20/M20A_hydrolases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017144">
        <property type="entry name" value="Xaa-Arg_dipeptidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575">
        <property type="entry name" value="PEPTIDASE M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575:SF4">
        <property type="entry name" value="PEPTIDASE M20 DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037226">
        <property type="entry name" value="Amidohydrolase_ACY1L2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="3">
        <location>
            <begin position="199"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF17579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="422" mass="45047" checksum="EC04B83ACAAB4CCA" modified="2013-06-26" version="1">MAEARSDESELLEEGLVMIEHQAKNPRLPTISDRIDHLSDVLRDISLKIHDHPELAYKETYAHDVITNFMAQYDDWKVTRSAYGIETAFVAVYDSGRPGPVVSFNAEYDALKGIGHACGHNLIAIASIGGALAAADLVREQTIGGKVVLFGTPAEEGGGGKIKLLKAGAYSDHAVDISLISHPGISPDSALVRTAAYSSFKVEYFGREAHAAASPWDGINALDALIIAYTATSALRQQTQPGDIIQGQIINGGLRPNIIHAYASGLFVVRSSSRDRLVALKKRVMACFEGAATATGARLEITPKGEYLDHVPNKALGRSYRNAFNQLGGSIPTGDLDVLTSATMASTDQGDISRAMPSISPNMCIKSASGGPHTPDFEKAARTEDAHRCALRVAKGLAATAIDVLTQPELLKEAKREFASIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNW6</accession>
    <name>N1QNW6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TATA element modulatory factor 1 TATA binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_146699</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765855.1">
        <property type="nucleotide sequence ID" value="XM_016903806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNW6"/>
    <dbReference type="STRING" id="692275.N1QNW6"/>
    <dbReference type="GeneID" id="27900943"/>
    <dbReference type="eggNOG" id="KOG4673">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013114_0_0_1"/>
    <dbReference type="OMA" id="EEMHGYI"/>
    <dbReference type="OrthoDB" id="74178at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052602">
        <property type="entry name" value="Growth_transcription_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022092">
        <property type="entry name" value="TMF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022091">
        <property type="entry name" value="TMF_TATA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46515:SF1">
        <property type="entry name" value="TATA ELEMENT MODULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46515">
        <property type="entry name" value="TATA ELEMENT MODULATORY FACTOR TMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12329">
        <property type="entry name" value="TMF_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12325">
        <property type="entry name" value="TMF_TATA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TATA element modulatory factor 1 TATA binding" evidence="6">
        <location>
            <begin position="755"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="31"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="176"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="512"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="608"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="658"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="733"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="310"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="764"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="31"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="78"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="610"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="622"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="669"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF17734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="864" mass="94524" checksum="77983AEF3093F717" modified="2013-06-26" version="1">MSAPPKKGWGSLAGNLLSNLENRLDTLLADEQQASAAQEARAAAQSKTNTSSSATTAAAVSTSSNKLAANGAAPPSRDASRTRVNDRLAERLAKATALKTSRPATPANDSPRPSEESRRAEDVLGSVPDIAVQAEGSALPEVVDKSDNVPLNSEEVTGGAVVDDQPLSLAASTLPLNPARLSGDGSRPSVDLASSRPSLDAPNGTHTPSDSAADQTKEEIQAYMERIDALQAKLTYLAKETVAAAKKANAAPSSTSLEKQLAEKDEKIALLMEEGEKLSKNELKQLQTIKKLRAKTTEDDKATVDLKKKFERAERSELELKMRLRKAESAERQAGEKMKQMAIIESQVDELRVDRENAAELIRSLTTQLKEANERAAAAEKSAVNKASEVDKRKIADLQNELEDAQIEKKLALDRAASETKKLREEAERQQERFSVRELEFKSEVSGLESRLEAMRARAEEASTTSGSNDGEGSIKLVRQVESLQQQYALAKGNWETIEGSLNARVAALERERDEATKRETDVRKRARDAGVKSRKAEEELEGAMDKIQSLTQEIASQQKQISALQDKLEQAETAQAEARIDLDRQRNTWEAELASRLEEERLKLRKELQSSSQYGGSVQSPTASQSRKMSDITSFRGKNLSRIASHDLSTLHIDQYQRPSSAHRRSPMTLQHSTSYSARSGGNGIGTPTEASPSISRRESMMLSSFQPQSGNDMPPTPSIGIIDRLSEVGGVGNDSNSPQHTMADLVSDSTAGPGAGPSVQLVERMSSLVRKLESEKASFKDELERLKQQRDEARDEVVGLMREVESSRKQEVDGEEMSTLKKRYEASLEMLGEREEEVEELKGDVVELKRIYKELVETKVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M3AT75</accession>
    <name>M3AT75_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycerate mutase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_92810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756840.1">
        <property type="nucleotide sequence ID" value="XM_016910594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AT75"/>
    <dbReference type="GeneID" id="27907731"/>
    <dbReference type="eggNOG" id="KOG4754">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039184_1_0_1"/>
    <dbReference type="OMA" id="NALPCDT"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF54">
        <property type="entry name" value="PHOSPHATASE SPAC5H10.03-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF08719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="236" mass="26046" checksum="F1AF6EA1E15DF923" modified="2013-05-01" version="1">MAPNSRIILTRHAQAEHNVGLDYSIHDAPLTPLGKKQAAALAPQVEALSQEVDLVATSPLKRTLQTTKLGWAPAISRLGGLEKVILLPEFQECNDFPCDTGSSQEILSQDPELHGFNFSHLPPDWTSKQGFWSADRTRIAQRAKWVRQWLRNRPEQTIVLVGHGDILRELTASAEGPSGYMWKNAEARMFTFDPSTVEGDECFLWQEKGKEVAVAGGYAPTSTEDDILGVGNGKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M3AVQ6</accession>
    <name>M3AVQ6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SEPMUDRAFT_143898</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ZNF598/HEL2 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758277.1">
        <property type="nucleotide sequence ID" value="XM_016903055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AVQ6"/>
    <dbReference type="STRING" id="692275.M3AVQ6"/>
    <dbReference type="GeneID" id="27900192"/>
    <dbReference type="eggNOG" id="KOG2231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008515_1_0_1"/>
    <dbReference type="OMA" id="VFTHEHT"/>
    <dbReference type="OrthoDB" id="3838338at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16615">
        <property type="entry name" value="RING-HC_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057634">
        <property type="entry name" value="PAH_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041888">
        <property type="entry name" value="RING-HC_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056437">
        <property type="entry name" value="Znf-C2H2_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044288">
        <property type="entry name" value="ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938">
        <property type="entry name" value="ZINC FINGER PROTEIN 598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23202">
        <property type="entry name" value="PAH_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25447">
        <property type="entry name" value="RING_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23230">
        <property type="entry name" value="zf-C2H2_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="147"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="412"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="641"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="793"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="454"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="490"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="641"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="654"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="728"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMF10156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="816" mass="87719" checksum="0A155F6E43C84824" modified="2013-05-01" version="1">MTLGLQMIPSTSGGESQGRGGRGGGRGRGGQRGGANRGASAEHHNGAPNDRGADRTRADGGGNRGRGRGRGRGGGGGRGGRGDSNHNNRDRAFSSAQQNTTAVQPSPEPGGTGVFGARLTKDAAHNIQGEGAGAQVEDGDDVEAEVCFICASPVSHNSVAPCNHRTCHICALRLRALYKTKACAHCRTEATNVIFTDDAEKRYEDFVERDFHRVDKNLGISYEKHEIFEDTVLLLRYNCPDQDCYEACLGWPDLHRHVRNTHQKVMCDLCTRNKKVFTHEHELFTHAELKRHEKFGDDHPGAVDQSGFKGHPECGFCRRRFYGDDELFSHCREAHERCHLCDRRNGGNTPQYFMNYDALEKHFSKDHFPCLDQECQEKKFVVFDSEMDLKAHQLEQHPNGLSKDARRVDLSAFDYRPQYQEPTRGRGGRRGGRGRDPNAEPLPASSAGNLSRAEVAHQREREIHSAQSVSARSFGGQLSAPTPAQAASRPAITQQTATQAAPQSPHPAAPLTPQEQARQLRHAAVNERASNLARNEKVKMDAFRERVSSYTRGGISPGDLIDALFSIFDTSSKEIGKLINELADIFEVPGKRDSLLKAWADWKAVNEDYPTLPGPAGANTTAAGVLGKGVGASRVLKLKSSTAKSSQSAVGRQASWGSASSTPAASSSNPFPSLPPRNGGPSIQLGRGSAAPAPTPSWLATRPATDSAARSPAMTPSSSARASPAINARQQPTGTNTRSAELFPALPAAKKPTSTVFSPGYTGRGILRTNSGNPSVNAWAGGSGTSTPVVDANAGQNDESVARKGKKGKQIVFKWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M3B049</accession>
    <name>M3B049_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable glucan endo-1,3-beta-glucosidase eglC</fullName>
            <ecNumber evidence="5">3.2.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Endo-1,3-beta-glucanase eglC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Laminarinase eglC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">SEPMUDRAFT_63835</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation and also function biosynthetically as a transglycosylase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 22">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="5"/>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761288.1">
        <property type="nucleotide sequence ID" value="XM_016909654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B049"/>
    <dbReference type="STRING" id="692275.M3B049"/>
    <dbReference type="GeneID" id="27906791"/>
    <dbReference type="eggNOG" id="ENOG502QQE6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028820_2_1_1"/>
    <dbReference type="OMA" id="WVWITET"/>
    <dbReference type="OrthoDB" id="77201at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000490">
        <property type="entry name" value="Glyco_hydro_17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF13">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE EGLC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00332">
        <property type="entry name" value="Glyco_hydro_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0134">Cell wall</keyword>
    <keyword evidence="17" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="12 24" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0964">Secreted</keyword>
    <keyword evidence="11 23" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004031688" description="Probable glucan endo-1,3-beta-glucosidase eglC" evidence="23">
        <location>
            <begin position="20"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00025152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00032134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00032906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="EMF13167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="289" mass="31530" checksum="91F23E19484A905E" modified="2013-05-01" version="1">MRFFSTITALAASAQSVAAYYKGFNVGANNPDGTCKTTSQWETAFNKLRGLPQDVSVVRLYASSDCNTLANAVPAAVTTNTKILVGIWTEDSAHYSAEKAALESAIQAHGIDWILAISVGSEDLYRGDTTASTLAQQIYDVRGMVRALGVQAEVGHVDTYNAWTNSANDDVIKACDFIGMDAYPYWQGSSIEDAYNVFFQAYQETKNHVQSVGSGAWVWVTETSWPVTGANYGSAVPSVANAQKFWRSVACELFNEGHVFWYAYQDYNDSPSFGVFDSNGNAIYDLYGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M3B529</accession>
    <name>M3B529_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_153837</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF14882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763003.1">
        <property type="nucleotide sequence ID" value="XM_016907532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B529"/>
    <dbReference type="STRING" id="692275.M3B529"/>
    <dbReference type="GeneID" id="27904669"/>
    <dbReference type="eggNOG" id="ENOG502QT4U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014765_0_0_1"/>
    <dbReference type="OMA" id="HVIDMVA"/>
    <dbReference type="OrthoDB" id="16911at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036121">
        <property type="term" value="F:double-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061749">
        <property type="term" value="F:forked DNA-dependent helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000403">
        <property type="term" value="F:Y-form DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032042">
        <property type="term" value="P:mitochondrial DNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18799">
        <property type="entry name" value="SF2_C_EcoAI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050742">
        <property type="entry name" value="Helicase_Restrict-Modif_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47396:SF1">
        <property type="entry name" value="ATP-DEPENDENT HELICASE IRC3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47396">
        <property type="entry name" value="TYPE I RESTRICTION ENZYME ECOKI R PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="69"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="287"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF14882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="668" mass="74147" checksum="D34A51E8EEEB0E02" modified="2013-05-01" version="1">MRGPTWLLRHVEPPKLLSRSQRSFGVPWQNPRSLSWTRPIATSPTSHQNEDKKVSLRPYQENAIQSVLGYLAKGGKRAGLSLATGSGKTVIFSHLISRVPPPTQDATQTLILAHRQELVEQAARHCRALYPDQTVEIEMAARHATGLAHITVASVQSLTRGDRLSRYDPQRFKMLLVDEAHHSAAAGYLDILNHFGLLNAPHVGPACLVGVSATFSRHDGMRLGKAFDDIVYHQDYMDMIQDEWLSPLILTTVQSGVKLDNVKQSADDFHIGALSKAVNNDKTNAVTVGAWMAKAQGRKSTLVFCVDLSHVASLTAMFRAHGVDARFVTSDTTKKVRSERLEAFKNGEYPVLVNCGIYTEGTDIPNIDCVLLARPTQSRNLLVQMIGRGLRKHPGKVNCHVIDMVASLETGIVTSPTLYGLDPDELVQEADGRDLQILKDKRQREQEREAQVLGTLSPSGQVPELSGEITFTDYDSVNDLIDDAAGERHIRQISRYAWVQIDESKYILSTQDGSFLRIQRDEEHPEQFIVTYTRKIQTSDAKNKKVLARPKPIAKAITFEDAVHAADTFASTTFPSVFVSTSAAWRRSNATNAQIDFLNTSRGADEKLAYGSLSKGRAGDMITKLRHGARGAFKRYAAKSRAAQRKAKKTEQWRSKLEKSRVQVGRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M3B6U6</accession>
    <name>M3B6U6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cyclic pyranopterin monophosphate synthase</fullName>
            <ecNumber evidence="3">4.6.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_147392</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:49580"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59648"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.6.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.17" evidence="3"/>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763653.1">
        <property type="nucleotide sequence ID" value="XM_016904270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B6U6"/>
    <dbReference type="STRING" id="692275.M3B6U6"/>
    <dbReference type="GeneID" id="27901407"/>
    <dbReference type="eggNOG" id="KOG2876">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_486766_0_0_1"/>
    <dbReference type="OrthoDB" id="429626at2759"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061799">
        <property type="term" value="F:cyclic pyranopterin monophosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01420">
        <property type="entry name" value="MoaC_PE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.640">
        <property type="entry name" value="Molybdopterin cofactor biosynthesis C (MoaC) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01224_B">
        <property type="entry name" value="MoaC_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023045">
        <property type="entry name" value="MoaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047594">
        <property type="entry name" value="MoaC_bact/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036522">
        <property type="entry name" value="MoaC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050105">
        <property type="entry name" value="MoCo_biosynth_MoaA/MoaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002820">
        <property type="entry name" value="Mopterin_CF_biosynth-C_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00581">
        <property type="entry name" value="moaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006870">
        <property type="entry name" value="PRK09364.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22960">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SYNTHESIS PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01967">
        <property type="entry name" value="MoaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55040">
        <property type="entry name" value="Molybdenum cofactor biosynthesis protein C, MoaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Molybdopterin cofactor biosynthesis C (MoaC)" evidence="7">
        <location>
            <begin position="351"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="121"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="291"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="61"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="197"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="251"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="318"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="330"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF15532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="560" mass="60618" checksum="189F0A83928F878A" modified="2013-05-01" version="1">MHLLRATPGSLQARHYSSSGGNDDDRQSSSKEESASPSSLTTGFGFQSLSGLFEQPKRGRYSTTRGSQQQSDAASSPEVSDHLANSRSEQPLRVAEPFFNRNNPVTMQDEDLSRIGSSFSADARPAEINAGSSDASTSKVTEETNPDGSLHAASSITTRRPIKDHAKDDETPTVIGEAFRRRFATSDDSESSNPGHSRTRRTFINRRLRGFSTQGTEIPVEPKRPNPFLVMSRTQAGKPGDDKRMAPRHTVSPQPKNSWGFSKGSQAHVNSLPERETNVAVSDGKSIESLEGLQQSKEDAVATSNSTATPPHRLATHAKTDPGHVERSRPTSSVETKPQLTHVTGSGEAHMVDVGAKRDTHRVAVATAFVKFRKPETLRLIQENNMKKGDVLGIARIAGIMAAKRTSDLIPLCHPLAISKVEVHVTAHAPRAFQRNGWLPGSTNGFIAIQARVDCVGPTGVEMEALTAATAASLTIYDMCKAVDKAMTIVSARVVYKSGGRSGLYEYEPWTAAMGSEWFAENGLVTEWSPGGQDTPPISKHVVAAPSRARLALKRRRKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M3BQ75</accession>
    <name>M3BQ75_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GPI-anchored cell wall organization protein Ecm33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_151991</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756419.1">
        <property type="nucleotide sequence ID" value="XM_016907174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BQ75"/>
    <dbReference type="STRING" id="692275.M3BQ75"/>
    <dbReference type="GeneID" id="27904311"/>
    <dbReference type="eggNOG" id="ENOG502QUZC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035846_0_1_1"/>
    <dbReference type="OMA" id="WANNITF"/>
    <dbReference type="OrthoDB" id="536881at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.20.20">
        <property type="entry name" value="Receptor L-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051648">
        <property type="entry name" value="CWI-Assembly_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036941">
        <property type="entry name" value="Rcpt_L-dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31018:SF3">
        <property type="entry name" value="RECEPTOR PROTEIN-TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31018">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12454">
        <property type="entry name" value="Ecm33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032301" description="GPI-anchored cell wall organization protein Ecm33" evidence="7">
        <location>
            <begin position="20"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="355"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF08298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="393" mass="40167" checksum="4C5BB958FC15C058" modified="2013-05-01" version="1">MAAFRYIVPALALAGSAIAQCGESGSTMTLQNSGDAMALSSCSTIKGSIAIDSGTTDNINLAGVTMIEADLIADNVTGLGSLSAPDLEEIGGRFDLNGLTILSTLSFPKLAKVDTISWIALPALQGLTFSNTGVQEVNMLTIDNTELASLDGINLQVADTIYIGNNRFLDSVNMQLGNVTESLTFTNNGADLVAEFPNLIWAYNITIRNLSSVAVPSLASVNGSLGFYGNTFMNFSAPNLTDVGGSLAFVSNDQLSNITLPELTTVGGGFQIANNSALEQINGFPKLATVGGALEFTGAFTAVELPELGDVRGAFTLLSTGDITSACDTFQGQAGSASAIKGTFTCTGQTDPEDGTSTTGTSASHTSSSAAHPMIIPGATGVLGVVAAIFGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M3BR32</accession>
    <name>M3BR32_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_152205</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756704.1">
        <property type="nucleotide sequence ID" value="XM_016907303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BR32"/>
    <dbReference type="STRING" id="692275.M3BR32"/>
    <dbReference type="GeneID" id="27904440"/>
    <dbReference type="eggNOG" id="KOG1305">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009020_4_1_1"/>
    <dbReference type="OMA" id="FLFFGSQ"/>
    <dbReference type="OrthoDB" id="28208at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF458">
        <property type="entry name" value="SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="377"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="461"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="483"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="517"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="10">
        <location>
            <begin position="149"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF08583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="554" mass="59955" checksum="B9451D9D7888179A" modified="2013-05-01" version="1">MARDTTNDPDAARKGGSNEEATGLLHAEHGTPRDDLGDDDEENHIVYAKPSSPVKESKPRTIRQSSFAQSRPNGEPRTPHRVRFEVSEPDAIGETHHDWIEEEDYMDGHASPGGQQRAPLLTGIEAPSVSVANDIEYLEEDLLESARPKSGLGSAFMNMANSIIGAGIIGQPYAFKQAGLLTGIVLLLVLTITVDWTIRLIVKNSKLSGANSFQATMEHCFGKSGLVAISVAQWAFAFGGMVAFCIIIGDTIPRVLASMFPSLHTIPVLGLLTDRRTIIVLFTLGVSYPLSLYRDIAMLAKASSLALISMVIILVTVLIQGPLAPDDLKGPIKSSLIINAGVFQAIGVISFAFVCHHNSLLIYGSLRTPTMDRFAKVTHWSTSISMIACLVMALAGYLIFGSKTQGNVLNNFPNDNFMVNIARLCFGLNMLTTLPLECFVCREVMTEYYFPTENFNPNRHLIFTTSLILSAMGMSLITCDLGVVFELVGATSACALAYILPPLCYVKLTTRRTWEVYAAYVCIAFGCTVMSISLIQAIGKSIRGDPGGGTCSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M3BSV0</accession>
    <name>M3BSV0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_135198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF09745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757866.1">
        <property type="nucleotide sequence ID" value="XM_016902689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BSV0"/>
    <dbReference type="GeneID" id="27899826"/>
    <dbReference type="eggNOG" id="ENOG502SNB9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061423_0_0_1"/>
    <dbReference type="OMA" id="FMVPTEY"/>
    <dbReference type="OrthoDB" id="5404599at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF58">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="86"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="327" mass="36883" checksum="A401FE91E87F6162" modified="2013-05-01" version="1">MAALPPVREALRQVTKQSWILGDRMSISRQLERSPDVPSWSDGNSCFFEITKSSGDVASDDTYGVADSLPLVHDAGDIHAVWKIGTAFLKVMVPLSTAITREHVTLQALQDRDVSFAVPSVLFYGEWDGRYYLIVSQVPGITLADAWPLMDETGRNKCVSQVVRICKEVAMTFDGSENSCIAGIDGGYLPEYFLGKRSGKDWDFAPALLQQYCLDMKMDCTTLVFYHCDLSPGNVMVHMKEAGEPAVGIIDWECAGFVPKDWVRTKYLVCGSMDFELPEGSTREARREWRDRMERCLQEEGFKDMSESWRAWFATGCSRYQVISWLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M3BSY0</accession>
    <name>M3BSY0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_119518</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF09775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757896.1">
        <property type="nucleotide sequence ID" value="XM_016901515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BSY0"/>
    <dbReference type="GeneID" id="27898652"/>
    <dbReference type="HOGENOM" id="CLU_1332676_0_0_1"/>
    <dbReference type="OrthoDB" id="195678at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF09775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="206" mass="22938" checksum="82E1F4C7E6C8C990" modified="2013-05-01" version="1">MTMHDTEQGHSLLHWATPSGFFNILDFVVHKMRPDGRATRTISHWPAQSPILSVDGVERWLNGCSSVGASSRTHCLSKIKNWFPWPNYTPATLRLIFEPIRNGELEIEHFAHQLGAPQVFRRPAVVSVDAGRRPSRSQWRSPMSGIGPRHCLRKQATPYAFDLTSSLSQTCSLNPTEMVLQSVTQGQCAGALCSCSGHMLVFEKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M3BTW8</accession>
    <name>M3BTW8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Flavin-binding monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_91159</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758221.1">
        <property type="nucleotide sequence ID" value="XM_016910549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BTW8"/>
    <dbReference type="STRING" id="692275.M3BTW8"/>
    <dbReference type="GeneID" id="27907686"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006937_6_0_1"/>
    <dbReference type="OMA" id="HIKSWVP"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF1">
        <property type="entry name" value="FAD-BINDING MONOOXYGENASE STCW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF10100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="599" mass="68537" checksum="C5FFF8EF0DDB5C76" modified="2013-05-01" version="1">MAPDLNGIAAGHRFDYSQPGSSGYSINQNITYNDPKNRKLRVLTIGGGVTGILLAYRLQKDASNVEHVIYEKNEDIGGTWLENRYPGCACDIPSHAYTYQFALNPDWPRFFAHSPDIWKYLDKVCNTFDLRKYMVFNTEVIGAYWNDDNGEWTVKLRQTAPGQEPREFEDTCHLLLHGTGILNNFKWPDIPGLMDKFKGKVVHTARWPKEYQKEEWANDRVAVIGSGASSVQTVPTMQPHTKHLDIFVRTGVWFVELVKDLGHAKEYDQKERDEYRRNPKALVAHAKSLEDQVNGMWGVFYAGTKEQMDGQEMNRARMAEFIKDKRLLEGFTPKFGIGCRRITPGDPYMMAIQEPNVDVHFTGVASCTEDGVVGFDGVERKVDTIICATGFDVSYRPRFPIVGKGGIDLKDKWKICPESYLGLAVPDFPNFMTFIGPTWPIENGSVMGPLHTVSDYAIDIIKKMQNENISSWTPRQDITDSFNEHVQEWIKHTVWKEDCRSWYKDNETGRVNAIWPGSSLHYHQVIGRPRYEDFEIKYRDSNPWAHLGMGWTMQDRSGPGEMDKSPYLSINHIDPKWYEAVGGNVDVLVKQMNEHNAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>M3BU24</accession>
    <name>M3BU24_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_151183</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758286.1">
        <property type="nucleotide sequence ID" value="XM_016906655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BU24"/>
    <dbReference type="GeneID" id="27903792"/>
    <dbReference type="HOGENOM" id="CLU_2211630_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF10165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="107" mass="11749" checksum="D14A3AB8B838EB5C" modified="2013-05-01" version="1">MLPSVKNYQSVFARVVRSSLTPSHLMSLTDLGSEGKVFETVGRTAMRPPSAAGDCPLHPHDDLVKDHIYAMCIHPPEGSMSSAGVEVKTGRQAFEILRKTARRQETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M3BYI7</accession>
    <name>M3BYI7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PHF5-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_140603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PHF5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761247.1">
        <property type="nucleotide sequence ID" value="XM_016902939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BYI7"/>
    <dbReference type="STRING" id="692275.M3BYI7"/>
    <dbReference type="GeneID" id="27900076"/>
    <dbReference type="eggNOG" id="KOG1705">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110369_1_1_1"/>
    <dbReference type="OMA" id="AYYCWEC"/>
    <dbReference type="OrthoDB" id="10248186at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005345">
        <property type="entry name" value="PHF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13120">
        <property type="entry name" value="PHD FINGER-LIKE DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03660">
        <property type="entry name" value="PHF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016468">
        <property type="entry name" value="PHF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF13126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="108" mass="12224" checksum="BAF4214FCDA2923A" modified="2013-05-01" version="1">MSRHHPDLVMCRKTAGISIGRLCDKCDGKCPVCDSYVRPTTLVRICDECAFGNYQNKCVVCGGEGISDAFYCFECTRLEKDRDGCPKIINLGSSRTDLFYQKKNFRNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M3BYQ9</accession>
    <name>M3BYQ9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_162984</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761327.1">
        <property type="nucleotide sequence ID" value="XM_016908025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BYQ9"/>
    <dbReference type="STRING" id="692275.M3BYQ9"/>
    <dbReference type="GeneID" id="27905162"/>
    <dbReference type="eggNOG" id="ENOG502SNKW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013866_5_1_1"/>
    <dbReference type="OMA" id="YHDVWIA"/>
    <dbReference type="OrthoDB" id="2991872at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DBAG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="61"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="77"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF13206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="578" mass="63655" checksum="4367A84D9C61030F" modified="2013-05-01" version="1">MPFRGRPSKGCGTCRRRKIKCDLREGGCERCERAGWDCGGYRDLTSLMFHDESERVIEKVHAQKGTRRPAESAPEVSLSPSTTASTTIASPSDRASDLAVEELPSATLLTRSSTRDSAVELSCHGGGSNPSFSPRASPANSLPGLDDLALAYFFDTYVYKYNDKRDQWDIEVGNGCLLAAVKALGTAGAVSQIGRSHQLEAEAQKQYVDAIRKTNNALQNSTERTRDSTLVAITILGIFENVSGFQRNLDSWREHVNGAASLLQLRGSKQFSTQTGCRLFLQTCTNLILSCLSRRLPIPAHVRAMQKVAERFIPDPTESVWRFHLAGLRIADLNARLLPGNYPASPPQAQSIVDDALALYAELESILADAPEDWKPRYRGATGQMIYSDYCYVFDSYIIAQIFSGNWGYRIMLTDVLRKALVNLRASGNKVDRAQLDRIQFYIGSVRQLQLNILAVIPQHLSHRFPIHYTTDASGHITEQPSSGFNSRNHNPFRHAEENEVALPFVRMSGGYQTQFPLFAAGAADPPGGPVRMWVIGALKTLHQSMGVQQAAVLASQLEGDDSGSGIPEDLWHCTLPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M3C1Q7</accession>
    <name>M3C1Q7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">2-dehydropantoate 2-reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_148019</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762367.1">
        <property type="nucleotide sequence ID" value="XM_016904654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C1Q7"/>
    <dbReference type="STRING" id="692275.M3C1Q7"/>
    <dbReference type="GeneID" id="27901791"/>
    <dbReference type="eggNOG" id="ENOG502S3CY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031468_2_0_1"/>
    <dbReference type="OMA" id="THREIEY"/>
    <dbReference type="OrthoDB" id="3609at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000017">
        <property type="entry name" value="2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051402">
        <property type="entry name" value="KPR-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708:SF30">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708">
        <property type="entry name" value="PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="5">
        <location>
            <begin position="4"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="6">
        <location>
            <begin position="225"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="169"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF14246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="371" mass="40408" checksum="85392C6D54D6CDAC" modified="2013-05-01" version="1">MPRILLHGTGAIGTIYAYQLMQAGCDVTVTCRSNYEAVIKQNGFHLDSVIYGEGLHLQPKVVRSPLEAVENSSSSNEEGEGEGVYDYLLVACKAIPEAQISETIAPAVTRGRTTIVLLQNGIGIEEEYSKKFPENLLLSGVVYCPVTQTSPGYITMGDVERLEIGEFSSSSSSSSASSVENNNKNSTTTTTTTTTTEIHPSTSKFLSLLKSGGGNPIHYHPSTSMQERRWFKLLLNAPWNPICALTLSRDLAFLAAEPCTSLAVIRGVLDEVIAISRALGYHSVTAEAAEQGLATIMSREGIAGIEPSMLVDVLWTRRMEHEVILGNPVRVARKLGVEVPRMEMLYALVKALDLSHQKRKEGRSLDMYDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M3C2A7</accession>
    <name>M3C2A7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_132065</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762517.1">
        <property type="nucleotide sequence ID" value="XM_016902468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C2A7"/>
    <dbReference type="STRING" id="692275.M3C2A7"/>
    <dbReference type="GeneID" id="27899605"/>
    <dbReference type="eggNOG" id="KOG0591">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_407770_0_0_1"/>
    <dbReference type="OrthoDB" id="310217at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF98">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="246"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="196"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="590"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="196"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="604"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF14396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="674" mass="75048" checksum="B08BD796D6FC3D96" modified="2013-05-01" version="1">MAEGALAAEARELREAQHLYVLLEAQSHKVAPLTLGTTNVAFRDAAIAAFNGLSTLAKMDLGDTIRKFRLDNKATNDLSAHVIYAQRFRGAPGDDDDVLKHDGAHWRPTVQYFIRRKKEYLAAGREAEGAATSLVQALQDYDLDQERTVNFLQQCIEYWNAKNTQGQASIDRDLPLLENSARLRIADMEKARAEMLAEEKKEKEKRAGEEAMAEEEEEENADQDVVMGDVGDVEMQDAPAVLDVTWHGQVHLGAGSYGTADLWVGTHPDMSICHRVVRKNCDLRPIWSIDSFWTDGAPGNTGSTAGTGPTEIQALADLANKPGSDAIVALHNWRLRLGAQRADLYLEYCPYGDAFDAVLHGDYYSRRHGDRKIFPWVDYSRAGDISLVPEPFIWSTFLSLVMAGLLMERGSLEKNPDDPQQQHWPVIVHRDLKLDNIFMGVPATDRFRMYPQAKIADFGLSLMAPPNDPRPIHSLFCHGSPEHAPPEQHVALTDRHTGALVRQSTQSNVWGIGIILHSMLAGENGPVANNATWFDWTNPSRREPPEFDQTARGFYSAELRNLVLACLRFDAEDRPTLDYLFAEVTRYTTPATGGGGGDDENDEDKAKGMRDLKKEDDEERYADLLTRYRMQCGNNLDKYAVGLALPLTSFMADRTPVATVPAPLMQIAARMGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M3C2U4</accession>
    <name>M3C2U4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DUF159-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_132217</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SOS response-associated peptidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762712.1">
        <property type="nucleotide sequence ID" value="XM_016902483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C2U4"/>
    <dbReference type="STRING" id="692275.M3C2U4"/>
    <dbReference type="GeneID" id="27899620"/>
    <dbReference type="eggNOG" id="KOG2618">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035990_0_3_1"/>
    <dbReference type="OMA" id="GMWTTMK"/>
    <dbReference type="OrthoDB" id="2111841at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106300">
        <property type="term" value="P:protein-DNA covalent cross-linking repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1680.10">
        <property type="entry name" value="SOS response associated peptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003738">
        <property type="entry name" value="SRAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036590">
        <property type="entry name" value="SRAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13604:SF0">
        <property type="entry name" value="ABASIC SITE PROCESSING PROTEIN HMCES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13604">
        <property type="entry name" value="DC12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02586">
        <property type="entry name" value="SRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143081">
        <property type="entry name" value="BB1717-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0190">Covalent protein-DNA linkage</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="57"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="343"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="428"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="343"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="437"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF14591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="482" mass="53466" checksum="A91FE165C6060340" modified="2013-05-01" version="1">MCGRYALSLRPSQVRSRLVGQNMAVDEAPDDDAEPLRQSYNFAPGYHGLIYRAHTAGRNSNGNGNGNDNGNGNVNGNSNGNGNVNGNSNGNSCEDGEREHEDAEFSPTVSKRSHPIGESVVTKETKYKLQVAKWGLVPFWTKRQPDYGSQMRTINCRDDSLIEDRGMWNTMKQRKRCIVVAEGFYEWLKKNNGKEKIPHFTKRADGQLMCFAGLWDMVQYEGSEDMLYTFTIITTDSNKQLKFLHDRMPVILEAGSDEMKTWLDPNLVGWNRDLQSMLKPYQGELECYPVDKAVGKVGNNSPQFLIPVNSTENKSNIANFFGQQRATAKEVAAKNEAARCDQKAEVAKHGDENRVTTSNVESTEDNAPLPKPQDEVEEDLSQKVRAGRAEVDDAGQIEAADEYVDKGIKREISEVDCAASIMAAESPVKKAVKIEHPTPSSLKSPPSRSERRSTRSATSNNTILKTPDKGANAKITSFFSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M3C312</accession>
    <name>M3C312_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_140392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762787.1">
        <property type="nucleotide sequence ID" value="XM_016902936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C312"/>
    <dbReference type="STRING" id="692275.M3C312"/>
    <dbReference type="GeneID" id="27900073"/>
    <dbReference type="eggNOG" id="KOG4391">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043841_1_0_1"/>
    <dbReference type="OMA" id="CFWIVVM"/>
    <dbReference type="OrthoDB" id="10249433at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF64">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01760)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF14666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="364" mass="40019" checksum="3347204D13006C77" modified="2013-05-01" version="1">MHQWPTLPAEGVVQCIPFKHGSPIARAFWGGLPSILVPPVVFTSLLVGLWTYKCVMTVLFQDKVIYMPYMPPFARREKIEDYAAVCKPVTWEHLHIKSMDGTKIALCVGQCIPSEDGATQSKKAKKKVVICYFQGNGSSTPPRLPLLSNTLKAIKAEASIHDGADGVEFVLVALSYRGYWTSSGRASQTGIEKDAQAMLAWICNTQPVPHTKLDIVLWGQSIGAGVAAAAAASYSSQTEQRPQITGLILETPFTGIKSMLLALYPQRWLPYQYLWPFLWNHWDSEVALRNIATAKCLPHVLIMPATRDEVVPASEADKLECISRDAGLKTTRTDIIGALHTEATMRREGQLAVAGFIVDVAKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M3C383</accession>
    <name>M3C383_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_83341</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762867.1">
        <property type="nucleotide sequence ID" value="XM_016910333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C383"/>
    <dbReference type="STRING" id="692275.M3C383"/>
    <dbReference type="ESTHER" id="sphms-m3c383">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="GeneID" id="27907470"/>
    <dbReference type="eggNOG" id="KOG4389">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006586_10_4_1"/>
    <dbReference type="OMA" id="TFWGSEM"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005140278" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="20"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="36"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF14746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="575" mass="62369" checksum="10F5ABFBE9A677E9" modified="2013-05-01" version="1">MLLRLAAVITLTLCVAAHASSCAPTAITDTATYHGTYKSHVEAFLGVQYAQDTSGKNRFKPPIPFVPSGLLDATSPGPACPQLLGTNSLPLYLGNITATSEDCLRLNVFRPNGTTAGDNLPVMVYIHGGGFKTASKDDPVSQPGGMILLSIDNGSPVISVQINYRLGIFGFAQSAALKGDGSENAGLRDQRLALEWVHDNIRHFGGNPDIVLIHGQSSGGLAVGMQMMAYGASRPQIFHKAIGQSQILEGGITGNFTRNAMQDVADFVGCNATSLDSDDTVMCLRNLSMTDLFAAQNLTATNLNVGDIWLPVVDGDFLPAAPSELIASGKFYNTTTMIGWCEDDTTYFIDPSVANASATHAYFADYLPGFSPSHLETLLDLYPESEFEPAYFPNGTVALAKEVRRAGRILRDIIMTCQPIYFGRALAAAGNDVYLYDQNQTFVTPILETNYSQYGYGVPHTSEFAYMFGNLSHYDIYDFPFEPQSEDYALMERQSKSWTSFAAWGRPSINGTTLQGWHRADFDDANYGIQIIGGPHEGYAGVNGSDSAREALRGQKLRERCGFLTSPEIVQQTNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>M3C389</accession>
    <name>M3C389_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Heavy metal tolerance protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_148376</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762872.1">
        <property type="nucleotide sequence ID" value="XM_016904883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C389"/>
    <dbReference type="STRING" id="692275.M3C389"/>
    <dbReference type="GeneID" id="27902020"/>
    <dbReference type="eggNOG" id="KOG0056">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_6_1_1"/>
    <dbReference type="OMA" id="YYGAEHY"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044604">
        <property type="term" value="F:ABC-type phytochelatin transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036249">
        <property type="term" value="P:cadmium ion import into vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098849">
        <property type="term" value="P:cellular detoxification of cadmium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071996">
        <property type="term" value="P:glutathione transmembrane import into vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036246">
        <property type="term" value="P:phytochelatin 2 import into vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18583">
        <property type="entry name" value="ABC_6TM_HMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03253">
        <property type="entry name" value="ABCC_ATM1_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000186">
        <property type="entry name" value="ATP-binding cassette sub-family B member 7, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000050">
        <property type="entry name" value="Vacuolar ABC heavy metal transporter (Hmt1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF651">
        <property type="entry name" value="HEAVY METAL TOLERANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="355"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="390"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="473"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="497"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="576"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="358"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="676"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="56"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="266"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="925"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="282"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="312"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="925"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="977"/>
            <end position="987"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF14751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1055" mass="117238" checksum="C570A689D86FEF59" modified="2013-05-01" version="1">MAETEMANANRSQTAWVSNPTASRILNYLQIAYPIVLLVLYLTTFTVRSVVTARSDHDTHQQPEQLGPGGKPLPKKKHTTPKKESEITPDLDFARPRKLLFEWLSVGVVLSLSANILVVVVHAISARHEGWWCGQAPTIYLVGSFMVYILLIIHMIESKPSPTLAHFATWVTAILMETILLGASFAVYTSEHREPKAGHPRGGELRRDMSEWEITEVTIDIIRIFILLALAAFYTLFVFLHDLVVHKRSPSPPHAASEGDETTALLSNGHADETGGNHHHGAANGTTHAAYGATNGKAHGPAGASNGQGRRRHEEVPAGWEKPKQTPSRSWWEYIRAYAVFLPYIWPSKEPKLQLNFVICFVIVFIQRGIQILVPIQLGEITRILAEGDVYMPWIAISLYIVYRLFQGSNGLLGAARQVLWIPIEQYSYRELSVAAFEHVHELSLDFHLGKKTGEVLSALGKGASLNTFLESVTFNVLPMLIDLGAAFVVFLVEFDAYYALVIVVVTFWYIYITIRMAAWRAEIRREATNASREEDAVKNDSMMSYETVKYFNAEAYEFNRYREAVKKYQKAEYQVTFSLALMNTIQNLVFMFGLIIASLLAAYQVTTGLLGVGKFVLLVTYMTQLQGPLNFFGTFYRMIQNNMINSERMLELFKEKPTVVDSPDAQTLPSCEGEIRYNQVQFSYDNRKPALQGLDFTCPPGTTTALVGESGGGKSTVFRLLFRFYNTQEGVIQIDGHDVENVTIDSLRQHIGVVPQDTVLFNETLMYNLKYARQDATDEDVFAACKAASIHDKIMGFPDQYDTKVGERGLRLSGGEKQRVAIARTIIKNPRIILLDEATAALDTETEEHIQEALKTLAHGRTMLVIAHRLSTITMCDQILVLHQGKVAERGTHTELLGQRGKYASMWRKQVRAQRAAEEAKVLKEKADRLRRESMDSSAVRTRQSKDEDTPPSSDEDEHARNKQPAEYGGGGGSGSSELQSALSLSPKSAIPHAHISSVLGGGRGDTGTDTRPQLEALRSGTVRSPSPVVEEEGPTRKPAAAAAAAPPRPAGHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M3C5X9</accession>
    <name>M3C5X9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_25985</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763807.1">
        <property type="nucleotide sequence ID" value="XM_016908402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C5X9"/>
    <dbReference type="STRING" id="692275.M3C5X9"/>
    <dbReference type="GeneID" id="27905539"/>
    <dbReference type="eggNOG" id="ENOG502SVGI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_328728_0_0_1"/>
    <dbReference type="OMA" id="PVYYPNY"/>
    <dbReference type="OrthoDB" id="5226996at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="114"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="291"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="590"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="234"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="394"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="590"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="618"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="654"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="676"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="716"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="752"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF15686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="776" mass="85807" checksum="53E678B844EAD942" modified="2013-05-01" version="1" fragment="single">MEESPSPPPVPPKDDYYSAGGGGGKVGSMESTRLASSSKRRRDAQDDISYHYGTADLEAGSNNDRPTPSKRSRSHAAASDGEISDSTSQHAAQLRRKGGIRNLSNLNLRHAASTSVLPARQASPPRESRFVEGSLNDKPSQQPPSVFTRVTRTDSGSLQYVEELMADYHKGMPTPWSTVQNTIEYEKEIMPERVAAINARSKNEDGAGIFRFGKSWGTNFHPVALWNRLWSDTKEEVTRQNMLEAERKDRLKAEAEAKYAQMKRAGLFGVPPAGSTEVASTPQDSAIALDSGTDEHHQTESLDSHARYSHEEQSQEGAAVQEPPRTLRGRLSRMQLRKPSMTSLSGTVKRAKSEFNLAALHRDSSASLSPSKIGLDGASSVLRSSASKYDLKKQNRLSKRVSNLEEKLQLARMELDTALAEASPAPKLTSKFERFTPVNSMKRKTRRPKFIPGALPTLPSERLLFPELRGPETYEETVPRAESEVRTHKIIDLSTAFDDIDDEGTIRRPHVQSHRPHAKEIFQDTDQSIAQTIRSIEEKRELQAKNPANQSIQLDQVDQEIVHNVTASNAEPGNAILDAKLKALDVSVKAAKKPAKSKKRGALAVEDKSFNPGRGVDNDDEEWEEAEQLSTKKKRKSAGKAEHSPPMKKSTAGQKQKSPQSKTTKKTATTTRSKKLNADKQTTEVEVTKSQLIENTGMDDAVLSEDELARPKTAEEGDDLILEPLYEEEEEMSVMPLNDEPREPTATATPARHGRSAVRPRSNSMHKRASRATSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-05-03" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M3C7J6</accession>
    <name>M3C7J6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_121780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456314">
        <property type="protein sequence ID" value="EMF07875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016755996.1">
        <property type="nucleotide sequence ID" value="XM_016901729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C7J6"/>
    <dbReference type="GeneID" id="27898866"/>
    <dbReference type="HOGENOM" id="CLU_1994040_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF07875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="126" mass="14642" checksum="0BCD74CD6FF73A7E" modified="2013-05-01" version="1">MPKRKSNAPEALANKRAKLGAASKLLEEYSLKPNTLRDREPRNESFARFKKVQIKEYTSFESLAKDKQQELIEGWRKIHTKEYNQKATKKQTGKSTTLPPDKQAKIDEADWFLELGDIDSKERLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M3C8P8</accession>
    <name>M3C8P8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_53989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_2564800_0_0_1"/>
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    <dbReference type="OrthoDB" id="5022336at2759"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF08260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="82" mass="9812" checksum="2A27894D5F521236" modified="2013-05-01" version="1" fragment="single">IDIKTTFLYSDIDIEIYVNLPLGFKVKGKVYKLKKVLYRLKQAPRIYFSLYLLDSVVFKKDNYFILVYVNNLLITRPNLKFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M3C8Z0</accession>
    <name>M3C8Z0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_152024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756456.1">
        <property type="nucleotide sequence ID" value="XM_016907196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C8Z0"/>
    <dbReference type="STRING" id="692275.M3C8Z0"/>
    <dbReference type="GeneID" id="27904333"/>
    <dbReference type="eggNOG" id="ENOG502R9SX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_432902_0_0_1"/>
    <dbReference type="OMA" id="YCRDTHP"/>
    <dbReference type="OrthoDB" id="3649848at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="401"/>
        </location>
    </feature>
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        <location>
            <begin position="416"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="478"/>
            <end position="495"/>
        </location>
    </feature>
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            <begin position="504"/>
            <end position="518"/>
        </location>
    </feature>
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        <location>
            <begin position="519"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="584"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF08335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="632" mass="62431" checksum="0596CDD890822D61" modified="2013-05-01" version="1">MGLISKIEEKLSGSSKSHTEEEKLRQQQALDTSRTKDTTTGTSSSSTGGLTGHGSHGTHPGQTTGTTSTTGIYNPLHNSGNSPTHGGSSGITGGTHPLVTGANTSQGVGQTHAPSSGLTGAGTTAGVPSGSHHTSGLSGQGSHFAGQDHGNTHHTGMGVGSGTQHSGAGVGSNAPHTGIGSNTHGSGITGGTAIGAQDYAPGTHAQGTNPGLAAEKTTASQPYDPYSSKGQNIAADAAAHQGHHNTHNTHNTHNTHHTGTSGVSEGTGFVPGSHPHANNDSAIPTAGGQKVGGVGEGVGHSHSGVHQTTGDKIKNVLPGQHNAHDAYGNPIKESTNASHSSSSHPGSHATGAGIAGTSNSGVGQSHAGSGLTGSHGHSNVTGSHNNYSHPNQPGSGFSSAAQPLGHDSSFTDRHAGPGAATGLAAGAVGGAGLASAGHHNNHSTQQPGSGLTGSHGGMSSTAPGSGFTGAHQDEYTRGQQAAYQQHGGHSQSGHHNTTSGYAGEDNRGMMDKVKDKMSSQRSNQPDDPVTGTNYDQRNREQYQPQGTGLTGSHPQGSGLTGSGNPTGYSSATHHQPGVGGITSGVDNTHIGSHSGMGSNTTSTTAPGISHEGRGAAYEAGFKDAVAALQGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M3C982</accession>
    <name>M3C982_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Multifunctional fusion protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="10">Delta-1-pyrroline-5-carboxylate dehydrogenase</fullName>
                <shortName evidence="10">P5C dehydrogenase</shortName>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="9">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
                <ecNumber evidence="9">1.2.1.88</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_166855</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>L-glutamate 5-semialdehyde + NAD(+) + H2O = L-glutamate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:30235"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="EC" id="1.2.1.88"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.88" evidence="9"/>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756521.1">
        <property type="nucleotide sequence ID" value="XM_016908265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C982"/>
    <dbReference type="STRING" id="692275.M3C982"/>
    <dbReference type="GeneID" id="27905402"/>
    <dbReference type="eggNOG" id="KOG2455">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_4_1_1"/>
    <dbReference type="OMA" id="FRHYIQE"/>
    <dbReference type="OrthoDB" id="5322683at2759"/>
    <dbReference type="UniPathway" id="UPA00261">
        <property type="reaction ID" value="UER00374"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003842">
        <property type="term" value="F:L-glutamate gamma-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000006">
        <property type="entry name" value="1-pyrroline-5-carboxylate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000005">
        <property type="entry name" value="1-pyrroline-5-carboxylate dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005931">
        <property type="entry name" value="P5CDH/ALDH4A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050485">
        <property type="entry name" value="Proline_metab_enzyme"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01236">
        <property type="entry name" value="D1pyr5carbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862:SF1">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0520">NAD</keyword>
    <keyword evidence="3 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 9" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="11">
        <location>
            <begin position="83"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF08400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="568" mass="62554" checksum="42798F815C47CB85" modified="2013-05-01" version="1">MKSTRAARSWKGPLIQLSTQQRAGISRYTLPVFKNEPVKSFAKGSPEREDLTRTLQQMKQKLPQKIPITVSGKVINSTTESIQLNPCRHAEKVAEYASASEQDTNAAIDAALAAKPAWEALPFEDRAAVFLRAAELISGKYRSEILAATMLGMGKNIRQAEVDASTETIDFLRQYVKEAEKLFEQQPPVNLDGTWNRNEFRPLEGFVYAISPFNFTALAATLVGPPALLGNVVIWKPSDSALHASWVLYQILLEAGLPKDVIQFLPGNPELITDTVLKRPEFAGLAFIGSTAVFKELQGKVGKATAEGRFNSYPRVVGETGGKNFHLVTESADVKSAALNTLRAAFEYQGQKCSACSRVYVAESIWPEFKSHIQHHTSQLRVGPPEDYSAFVNAVIHERSFNKLSSVIHDAKSDPELHLLAGGIVDNSSGFYIHPTIYQTTNPTHPLMSTELFGPIFCIYVYPDEKLDETLHLINSTSRYALTGSVFAHDPMISRKVQNALKHAAGNFYVNTKCTGSVVGQQPFGGMRDSGTNDKSGTMGMLMRFASVRTIKEEFASLEEVGYPSNEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M3CAV4</accession>
    <name>M3CAV4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_128518</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757066.1">
        <property type="nucleotide sequence ID" value="XM_016902218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CAV4"/>
    <dbReference type="STRING" id="692275.M3CAV4"/>
    <dbReference type="GeneID" id="27899355"/>
    <dbReference type="eggNOG" id="KOG4389">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006586_4_1_1"/>
    <dbReference type="OMA" id="VMSESTH"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004031857" evidence="3">
        <location>
            <begin position="26"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="34"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF08945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="372" mass="39886" checksum="0C9089CC76EBF31B" modified="2013-05-01" version="1">MRLLGAGRCVLLLLQLLTTLPFGSAQHAAPRDDELIVSTTSGVVQGTFDPELPNVRQFLGIPFAKPPVGDLRWAAPEALSQEEEQITATELPPSCPQTYSTGASVYHWDVLEFNLQGLNQTGAISEDCLFLSVWTPTQQNVETATTKGQLDAGLPVLVYIYGGAFAGGGIDVPYQIPTQWINRSPNHIVVSLNYRVNIFGFPSAQGLEDQNVGLLDQRLAVEWVKANIAQFQGDPNRITLWGQSAGAASVDMYGYAYPDDPIVAGAIMDSGVAGLLEGISVTDSGGSNFSYVASQVGCPDLADQPEQQLACMRTIDFQTISDFVGHYSGSPGISFVPTPDEKVVFSNYTDRALAGKQASIVSTLPHPSPTLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M3CCR5</accession>
    <name>M3CCR5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pre-mRNA-splicing factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_151202</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in spliceosome maturation and the first step of pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the SPP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758323.1">
        <property type="nucleotide sequence ID" value="XM_016906669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CCR5"/>
    <dbReference type="STRING" id="692275.M3CCR5"/>
    <dbReference type="GeneID" id="27903806"/>
    <dbReference type="eggNOG" id="ENOG502RZY8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033338_1_0_1"/>
    <dbReference type="OMA" id="AWGKSAM"/>
    <dbReference type="OrthoDB" id="5577072at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045166">
        <property type="entry name" value="Spp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026822">
        <property type="entry name" value="Spp2/MOS2_G-patch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15818">
        <property type="entry name" value="G PATCH AND KOW-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15818:SF2">
        <property type="entry name" value="G-PATCH DOMAIN AND KOW MOTIFS-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12656">
        <property type="entry name" value="G-patch_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="G-patch" evidence="6">
        <location>
            <begin position="222"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="122"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="279"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="312"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU369096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF10202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="435" mass="49816" checksum="FB82AE2142189273" modified="2013-05-01" version="1">MSGNKISLSLGGARKLPQLTHGVKRPRTALHDEDDDGATMDKAQAVSHFDSTAGGAVNASKEEEKNAPLLIAPQANRDWRDKASQRKRQKSGLPGNQDGSRADLDARMRDVEAKVEASKPKFGLNTYNNKRGNAEDEVMSGTGNISTNDDSISRNTEEKMEAAKSKTDDELAMDALLGKTTTDKTLIIEGNNAPMTEGDAFEHDVASAPDMATLDDYARVPVEQFGAALLRGMGWKDGEGIGSQKGKRLAKDTGKLPERRAALLGIGAKENAAMAQELGAWGKASRGKDAKIYNPVLIRDKKTGKTYTEEELEKKKQDEERRKYEMEFEKRERDRKPRDGEHHASRDRRRDHSRERTHGKEDRREREKSRRKDDPDSEAEYRRRKEREQHRRRERDEDYDRDSRRHRDHDSSGRERHHERDRRERDRERERERRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>M3CD82</accession>
    <name>M3CD82_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Acetolactate synthase</fullName>
            <ecNumber evidence="4 12">2.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SEPMUDRAFT_150058</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 pyruvate + H(+) = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="12">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="4 12"/>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759142.1">
        <property type="nucleotide sequence ID" value="XM_016905940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CD82"/>
    <dbReference type="STRING" id="692275.M3CD82"/>
    <dbReference type="GeneID" id="27903077"/>
    <dbReference type="eggNOG" id="KOG4166">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013748_1_2_1"/>
    <dbReference type="OMA" id="QETDMIG"/>
    <dbReference type="OrthoDB" id="16262at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901705">
        <property type="term" value="P:L-isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02015">
        <property type="entry name" value="TPP_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000008">
        <property type="entry name" value="Acetolactate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000007">
        <property type="entry name" value="Acetolactate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000053">
        <property type="entry name" value="Acetolactate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012846">
        <property type="entry name" value="Acetolactate_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039368">
        <property type="entry name" value="AHAS_TPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00118">
        <property type="entry name" value="acolac_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF13">
        <property type="entry name" value="ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="THIAMINE PYROPHOSPHATE ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="16">
        <location>
            <begin position="106"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="14">
        <location>
            <begin position="305"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="15">
        <location>
            <begin position="515"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="32"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMF11021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="706" mass="77181" checksum="0D7DC28F0E262970" modified="2013-05-01" version="1">MTTFAMIPSRAANAAKIARQTRQFASSSRIAAISPYRKHTPQPVKETKRTVSATAKSNAQAAAQPAPAQQRAVPSPAFNRDEPKSREPQPLQPFRQPEMDHSFVGMKGGEIFHEMMLRHNVKHVFGYPGGAILPVFDAIYNSEHFNFILPRHEQGAGHMAEGYARASGKPGVVLVTSGPGATNTVTPMQDALMDGTPMVVFCGQVPTSAIGSDAFQEADTVGISRACTKWNVMVKNIAELPRRINEAFEIATSGRPGPVLVDLPKDVTAGILNRPIPMMSTLPTHPSAATTAARDLSLKQLHGSIKRTADLINIAKKPVIYAGQGILGHVDGPKYLKELSEKVQIPVTTTLQGLGAYDELDPKSLHMLGMHGSAFANMAIQEADLIIALGARFDDRITGHVPRFAPQARKAAEEGRGGIVHFDIMPKNINKVVQATEAVEGDVTANLALLLPHVNEVSKDSRKEWFDQIDAWKERFPWAYQKEDGPDGVIKPQTVITALSDLTAPKKHETIITTGVGQHQMWTAQHYRWRQPRSMITSGGLGTMGFGLPAAIGAKVAAPEKLVVDIDGDASFLMTQTELGTASEFNIGVKVIVLNNEEQGMVTQWQSLFYSDRFAHTHQRNPDFVKLAEAMYVPARRTTKLGTLAEDLEWLCYGSGEGPAFLEVVVDQKIPVLPMVPGGSALHEFLVYDEKKEKERRQQTRDRSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M3CDR5</accession>
    <name>M3CDR5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycoside hydrolase family 13 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_150164</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759277.1">
        <property type="nucleotide sequence ID" value="XM_016905993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CDR5"/>
    <dbReference type="STRING" id="692275.M3CDR5"/>
    <dbReference type="GeneID" id="27903130"/>
    <dbReference type="eggNOG" id="KOG0471">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024572_2_0_1"/>
    <dbReference type="OMA" id="CVVIMSN"/>
    <dbReference type="OrthoDB" id="550577at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11318">
        <property type="entry name" value="AmyAc_bac_fung_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013776">
        <property type="entry name" value="A-amylase_thermo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006968">
        <property type="entry name" value="PRK09441.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006969">
        <property type="entry name" value="PRK09441.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43447">
        <property type="entry name" value="ALPHA-AMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001021">
        <property type="entry name" value="Alph-amls_thrmst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="7">
        <location>
            <begin position="5"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF11156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="506" mass="57155" checksum="D2E8411AC7AEE7C7" modified="2013-05-01" version="1">MPENATLLQGFEWNIPADGKHYQRLLKALPSLKNAGVDNLWLPPGCKASSPEGNGYDVYDLYDLGEFDQKGGKRTKWGTKDELLELSAKAKELGIGLYWDAVLNHKAGADKKEKAHAVEVADDDRTKEVTEPYEISAWLGFDFPGRGDKYSKQRYHWYHFSGTDWNAATEKKAIYKLKGDGKNWSESVDDEGGNADYMMFADIDYSHPEVQEDVKAWGKWIVEEVGLEGFRLDAVQHFSQRFTNEWVDTVREKHGKEVFMVGEFWTSDRDNMLKWLDEMDHKFALFDAPLLYNFNRISTTPDSDLRTIFDNSLTKADPISSVTVVMNHDTQPGQTMDTPVEGWFKPLAYALILLQDAGYPCLFYGDLYGLQEGNEGAQAQPPAADGKIPDMALARKLYAYGQQDEYLDDANCIGFVRRGNEEHWAGLACVMSNKGPGEIKMAVGEMHAGQVWTDVLGWEQGEVTIDREGYGVFKCAGTSVSIWVRKDAEGRERFPVQFDADIYHSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M3CDU1</accession>
    <name>M3CDU1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Quinate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_150187</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759307.1">
        <property type="nucleotide sequence ID" value="XM_016906007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CDU1"/>
    <dbReference type="GeneID" id="27903144"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_12_1"/>
    <dbReference type="OMA" id="PADHIYM"/>
    <dbReference type="OrthoDB" id="508119at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF34">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0672">Quinate metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="381"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="465"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="25"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF11186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="553" mass="60896" checksum="47CE97F2A2352698" modified="2013-05-01" version="1">MGGFLTLVEDRPTPKNVYNWRVYACATVASFASCMIGYDSAFIGTTLALPSFVDEFDFDSMSTSKLALVKSNIVSVYQAGAFFGSLFAYPSAYHVGRKWSLIIFSLIFTLGAGMMLGANRERGLALIYAGRVLAGIGVGAASMITPIYISEISPPAVRGRIVGIYELGWQIGGLVGFWINYGLSETMAPSHKQWIIPFAVQLIPAGLLLIGAFWLRESPRWLFSKNRREAALKNLCWIRNLQADDVYLVEEVAMMDAAMEEQAASIGLGFWKPFLAVKRNRKVQWRFLLGGLLFMWQNGSGINAINYYSPTVFKSIGVVGTNAGFLTTGIFGVVKTVLTVVWMFFLIDNLGRRNLLIIGAAGGSVCMWIIGGYISTKDTSAAAQAAAASQGLSSGGIAAIFFFYLWTAFYTPSWNGTPWVINSEMFDLNTRGLGQASASANNWFWNFIISRFTPQMFNSMGPSGCGVFFFFASMMILSIFFVWFLVPETKSIPLESMDRLFDISPPRKANKIILAEDQKRDAEFRENVNGAGLTTAKEKADLIEKSSERGSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M3CE06</accession>
    <name>M3CE06_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="8">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_47490</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the peptidase C12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="8"/>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759387.1">
        <property type="nucleotide sequence ID" value="XM_016909036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CE06"/>
    <dbReference type="STRING" id="692275.M3CE06"/>
    <dbReference type="GeneID" id="27906173"/>
    <dbReference type="eggNOG" id="KOG1415">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054406_0_2_1"/>
    <dbReference type="OMA" id="CISNGEA"/>
    <dbReference type="OrthoDB" id="427186at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09616">
        <property type="entry name" value="Peptidase_C12_UCH_L1_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF17">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="9">
        <location>
            <begin position="18"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF11266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="254" mass="27861" checksum="509B4EE6AEF10FCA" modified="2013-05-01" version="1">MAAPTTPGVYVNSMGKKTFIPLENNAEVFTDLIKRLGVSSEVGFYDVYSLDDVDLLSMVPRPVHALIFIAPAPVYYKTRAAYDGYDGHKKITYDASGKDEPVIWFKQTIGHACGLYSLVHAIGNGSSKDYIIDGSLIDRLLKEAVPLKRIERAKVLYNSKDLEEAHMASAVKGDSVAPSAEEPVGFHFITFTKGNDGHLWELEGSWDPIDRGALDESEDMLSARAIELGVGRFVKMAEGNIEFSIVALATRAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M3CE77</accession>
    <name>M3CE77_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="15">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SEPMUDRAFT_118646</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759472.1">
        <property type="nucleotide sequence ID" value="XM_016901447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CE77"/>
    <dbReference type="STRING" id="692275.M3CE77"/>
    <dbReference type="GeneID" id="27898584"/>
    <dbReference type="eggNOG" id="KOG0743">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010189_4_3_1"/>
    <dbReference type="OMA" id="TVSCFGW"/>
    <dbReference type="OrthoDB" id="10251412at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057495">
        <property type="entry name" value="AAA_lid_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25426">
        <property type="entry name" value="AAA_lid_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01024">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="BCS1 N-terminal" evidence="14">
        <location>
            <begin position="39"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="253"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMF11351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="487" mass="55145" checksum="1C2B39C3B0C10F9F" modified="2013-05-01" version="1">MSRLFHPDLHSHLAHGGFVRTTIEKLYQLDFTHLGSIVAVAGIIPAAWVYIRSAWRETSAWVRHFFIASVSIPAHDPVNRSVSTWLHEHVIEPRRLRFHIARTEPGRTSDPGAALKKSAPVQYLPQWQNIWFRHEAKMFAVSRDGFSSSSRDSDYDGFGGGELCISCLGVSSEPIKKLIETCRLAADQQAQFYVIIYCRDRYGMNWKPRLRRPLRRIDTVHFDERVKKALMTDIKTYLDPRTQKLYQSRSMPYRRGYLFYGPPGSGKSSLSTAIASEFGLDLYEVKIPSISSDADLEQMFSEVPPRCIVLLEDIDAVWTGRERQLPDSDDESSNSSSSNVTLSGLLNVLDGVGSQEGRIVVMTTNRLEELDSALIRPGRVDLKVHLGLISQQSARDMFISMFAPDLLHWARISSETVDTLEDHVSLEQVKILAAQFSEQIPEDTFTPSQLQGFFQLHLKSAVRATSSIAAWVKQQRLPDSEKEFEVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M3CFZ6</accession>
    <name>M3CFZ6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_133391</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the major facilitator superfamily. CAR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760849.1">
        <property type="nucleotide sequence ID" value="XM_016902562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CFZ6"/>
    <dbReference type="STRING" id="692275.M3CFZ6"/>
    <dbReference type="GeneID" id="27899699"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_1_0_1"/>
    <dbReference type="OMA" id="GYGWGFM"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000509">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF163">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="457"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="55"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF12728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="496" mass="53041" checksum="EDD0B1D01D841074" modified="2013-05-01" version="1">MAGAIADESSPLLVNNSVDTADGDHNAKGKNIIDFDPAGDVDDPYTWSATYKWSAVSLLALTAFTVTFTCISLVPVAGSIVRDLEDEADKNASVLLVTIWELGEAAGPLLIAPLSEAFGRYPVMNAANVLFIAATVLAALAPSAHVLIAARFLTGLAVASNVLNPAIVGDMFISEQRGTAMSLVQLAPLVGGALGPALAGYIAEGLGWRTVLWVSAALALFCEVTFLLLFRETFRVKILSMRAARLRKETGNTKLRTVYEVQGEMENASVWKQVMRPIVVFFGSGVLQAMSIFGSVVFTYFYVMSTTLPDILGSIYGLSPAATGAAFISFSAGSVVTVTLCNQTLDRIYIRLRDTHGKGVGHPEYRLPLVIAGGFLLPLVVAMYGWTAEAQLPLPVMLVSVALMGASLMLGFLPLTAYIVDAFGMYSASAMTAVIVTRCLVGTFLPLLTEPLVERIGYGLAFTVLAALSLSLAPIPVFIMRYGQKWRQNSTYTRHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M3CG22</accession>
    <name>M3CG22_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_86031</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760874.1">
        <property type="nucleotide sequence ID" value="XM_016910400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CG22"/>
    <dbReference type="STRING" id="692275.M3CG22"/>
    <dbReference type="GeneID" id="27907537"/>
    <dbReference type="eggNOG" id="ENOG502SGAZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024934_6_0_1"/>
    <dbReference type="OMA" id="TETLCMN"/>
    <dbReference type="OrthoDB" id="416217at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052400">
        <property type="entry name" value="Zn2-C6_fungal_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF14">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF12753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="430" mass="48558" checksum="49A40FEAB38C146A" modified="2013-05-01" version="1">MPRLNHRKARTGCQRCKARKVKCDEGKPKCLACARHNVPCEYVDPQPRRSEGHQAPSHCPGYGAVYPPSARQVAAIHNPVLAGELKLELRLMREWIVEICPILAADVTFWQKQATDLGLEHRIVLDAMFSLSALHLSWPLRGLAILDGANHNVSSRRDMLIVAQKYLQRALDGHGVAMNALNADNAKAVYATSVLLLYYSFFNLGEIAYEPTLPGYDHTFWTRLSGHTHYLCEQWAAMDHGEQLMAEWGVTFGRPPLPEAEELFSHEQGKPFTELLTFAEEYEANSTGNRAVYQQSVAYLAFVHRSIVQELDAPLINCQRLVAMPSQLGRQFTELIEQRAPRALLLLAHIFAMTKLLSDQVPWLRGIAERQVAPIQQQIPSAWQEMLRWPMETAFNPPNETTTDEQGNDQAIREMLQYNTDDKGQPVSQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M3CG48</accession>
    <name>M3CG48_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_66138</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760899.1">
        <property type="nucleotide sequence ID" value="XM_016909742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CG48"/>
    <dbReference type="STRING" id="692275.M3CG48"/>
    <dbReference type="GeneID" id="27906879"/>
    <dbReference type="eggNOG" id="KOG0159">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022195_9_2_1"/>
    <dbReference type="OMA" id="CMNIISR"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="473"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF12778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="527" mass="59835" checksum="B5501612D086CE06" modified="2013-05-01" version="1">MALLDIDDRSAGKLWLVISLALVLYCVTSIIVSKFTSQARFWRAQVWAGQQTGWFPRLRSGLKSIKGTRAMLDEAYWKYSKQDRPFAMPNFSQDPTVMLPQSMIKDFLQEPEENINLFAVLSEFMAIQYTGDADISTHPFHLEIVGNQLTRKLPLLTAEVQAELVLGFEDQWKVNSTEWTAIPAIGTCSTIVSRAANRVFSGATLCRTPEWLEHSGIYGQSIFMEASIINMLPRFLRPIAAPWICRNNYKHIQICQKYAVPVIEERFQAIRSGTLKTPPNDVLQWIIDKVMEMGDPVEMDPKRITRRLMRLNMVAIHTTSVTITNALLDLYSSPRAEEYVAGLREECERVLKQHGGQWNKTAVNELYRIDSTIKESMRFSSLGITGLMRKVTKPSGITLPNGTHIPYGIKIATPNVAIHRDPAFYPSPNEYDAFRYSRSREATTTTEPRTHHQAMLVTTSENFLSFGHGRHSCPGRFFAAQEMKLMLAYIVLTYDVRIEGTGRPKNIEIKGAAFPDPGARLLVRLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M3CGR7</accession>
    <name>M3CGR7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_117541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF13003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761124.1">
        <property type="nucleotide sequence ID" value="XM_016901348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CGR7"/>
    <dbReference type="GeneID" id="27898485"/>
    <dbReference type="HOGENOM" id="CLU_752640_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF13003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="368" mass="38598" checksum="4D0E1F940D64D05F" modified="2013-05-01" version="1">MDLSFYSRNKTQCTQGSAEASTKLGWQSEPSQANETMSSHYGPLQPRSPARRPRRSAFALSPIATGFGQPSVRSSIAVSSQRSANPSLTSALGAPTAALCIPERGNVVVQDDMMLDSRSDVEIMRDKAVALRKASARFKTKALCPISKPNSEVPPRSFTFSATLPSCEATSLSSSRLDPASLPFVPSSATTLAGVASAGTAPAPPESSSLPAPGIEERASKSAVKAPSSLAAPKVANIPDQAAADRVKVREVAERIMSRRAAERDVLDVYVDVPAATGSGVQSTSQMATMSDMPEMAAAHSCKIATAQASVSPASAGATPSFAAQMQVRIRQLLADHIDSDSNVDLVAELRDLADKISQDAETLEKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M3CJZ4</accession>
    <name>M3CJZ4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5-demethoxyubiquinone hydroxylase, mitochondrial</fullName>
            <shortName evidence="8">DMQ hydroxylase</shortName>
            <ecNumber evidence="8">1.14.99.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Ubiquinone biosynthesis monooxygenase COQ7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">COQ7</name>
        <name evidence="10" type="ORF">SEPMUDRAFT_147945</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzene-1,4-diol + AH2 + O2 = a 3-demethylubiquinol + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:50908"/>
            <dbReference type="Rhea" id="RHEA-COMP:10859"/>
            <dbReference type="Rhea" id="RHEA-COMP:10914"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:84167"/>
            <dbReference type="ChEBI" id="CHEBI:84422"/>
            <dbReference type="EC" id="1.14.99.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="8">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the COQ7 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.60" evidence="8"/>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762249.1">
        <property type="nucleotide sequence ID" value="XM_016904612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CJZ4"/>
    <dbReference type="STRING" id="692275.M3CJZ4"/>
    <dbReference type="GeneID" id="27901749"/>
    <dbReference type="eggNOG" id="KOG4061">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071892_0_1_1"/>
    <dbReference type="OMA" id="WSTAVMG"/>
    <dbReference type="OrthoDB" id="275371at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008682">
        <property type="term" value="F:3-demethoxyubiquinol 3-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160224">
        <property type="term" value="F:3-demethoxyubiquinone 3-hydroxylase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01042">
        <property type="entry name" value="DMQH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01658">
        <property type="entry name" value="COQ7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011566">
        <property type="entry name" value="Ubq_synth_Coq7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11237:SF4">
        <property type="entry name" value="5-DEMETHOXYUBIQUINONE HYDROXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11237">
        <property type="entry name" value="COENZYME Q10 BIOSYNTHESIS PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03232">
        <property type="entry name" value="COQ7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="25"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF14128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="247" mass="27793" checksum="E7D0CD0A32D0B34C" modified="2013-05-01" version="1">MLSPTLPLKARLTPLAFQLHTRRAFTSSAPRSLQHEVQPQTLDDKSPPPATARKPSKPLSTAQKKFLDSALRVNHAGELAATLIYTSQTPPIIKSHPHLRPLMQHMYDQEAGHFQKFNTLLAKHRIRPTAMYPVWQIAATVLGWSTGVLGREAAMACTEAVETEIGDHYNSQVRELLSWFKDMEARGEEPGEELRELIADIRRIRDEELEHLDHAVENDAKEANPYELLTGVIRGGCRGAIWLTEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M3CL57</accession>
    <name>M3CL57_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolase family 64 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_21618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762644.1">
        <property type="nucleotide sequence ID" value="XM_016908340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CL57"/>
    <dbReference type="STRING" id="692275.M3CL57"/>
    <dbReference type="GeneID" id="27905477"/>
    <dbReference type="eggNOG" id="ENOG502SJJ1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032886_2_0_1"/>
    <dbReference type="OrthoDB" id="3817117at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.50">
        <property type="entry name" value="Beta-1,3-glucanase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.110.10">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032477">
        <property type="entry name" value="Glyco_hydro_64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037398">
        <property type="entry name" value="Glyco_hydro_64_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042517">
        <property type="entry name" value="Glyco_hydro_64_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037176">
        <property type="entry name" value="Osmotin/thaumatin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38165">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38165:SF1">
        <property type="entry name" value="GLUCANASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16483">
        <property type="entry name" value="Glyco_hydro_64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52006">
        <property type="entry name" value="GH64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH64" evidence="1">
        <location>
            <begin position="1"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS52006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF14523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="313" mass="32967" checksum="F0973BCEC1814C24" modified="2013-05-01" version="1" fragment="single">PDPTVAMMSIDLGAIGNQVSVPLSEYVVGCRVYGAQDTLQLNSVTDANGVVSFVQPAVANPNDANYHKRFGILEFSWTAGTSCANPSHVDFADVAVGLEMITYSGARGGKMSVVGGLQGDAKARICEELRKVSSAQAPWSEGCLQSAAAGITRVLAPNEVIAANPAAFEGYFNAHHQTILETYSKTALIIKTGSGGSITCYTDPQSKMLHCDGVASVHFEPTAAEIFTCMGPFRQGSIEVMQMICAAYNRGTLLLDGGSVQPSLGRASYYTSPVHNAYARAVHGQLANSQGYAFAKDDIEARPEDAQAGLVCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2022-12-14" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>M3CLD8</accession>
    <name>M3CLD8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_115872</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762729.1">
        <property type="nucleotide sequence ID" value="XM_016901204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CLD8"/>
    <dbReference type="GeneID" id="27898341"/>
    <dbReference type="HOGENOM" id="CLU_1876722_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF14608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="136" mass="14969" checksum="5612D213AB2BCD5A" modified="2013-05-01" version="1">MRNSAYLEGANCTLLYLSGVVNMRSIMPANTQRLNSAFNICSRELQLHNDGMHIMSRAQGVIGFTGSSACVSESTISIAMVFTLVCAGELFTMRPDSGFYSVEYGSSRRHRSVAMLRAGRGDRSWPCDRKEASRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M3CM12</accession>
    <name>M3CM12_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_155443</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762944.1">
        <property type="nucleotide sequence ID" value="XM_016907619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CM12"/>
    <dbReference type="STRING" id="692275.M3CM12"/>
    <dbReference type="GeneID" id="27904756"/>
    <dbReference type="eggNOG" id="ENOG502QVWI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005937_0_0_1"/>
    <dbReference type="OMA" id="MGNTGMF"/>
    <dbReference type="OrthoDB" id="1747771at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="4">
        <location>
            <begin position="424"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="60"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="190"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="592"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="856"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="927"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="91"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="599"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="876"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="886"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="938"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="955"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="977"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1001"/>
            <end position="1010"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF14823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1018" mass="112219" checksum="0AEEF9759AFA7C68" modified="2013-05-01" version="1">MRHRLAHLPLPPSRLRSRLHLYCSSAMRLIACGLRLACLDQDRQSKFVLPLLPSRSLESLYSQDRESHTPPPNEPFQLRGLETSHGPVNYASASLTEEQVGNTRMTTTTSSSSSSSWAGYGPAAPAPAPVPSTTQCDRTKPCSACCARGHPKECEFVVGEGNDYSPIQQSYEIRKLRSENQRLKERLQAARLTQSGDEDDDGSSSDRKVSKGSARAAASRQRRFKTGDRVDNLYFGTPGLANIFANLQLGTQSLTHTIPRGKDIYVHDGQQSIYPFMNLWGGGSGAKDMARDLLASHDEIYKWLDVFQKRAQSCYFPHTPDELTRREVGRFLERTEENAEAHPDMLALIFTMVATAMQMGVYDQHGEWAPGAVEGSRFRSDVYIAAAMQALRLASFMNTPTLLGIQALVMIGPYLTNSGRFLDAWTLFGTTIRLAHSIGLHRDPKVLESAPQLRESMIRRTLWWWMLHMDQQYSVTLGRPLGISGIGDCQPPEPLTTNPTILRLNEFVDHFTILARQILSSDGMMNVGRIDEYTDKLLGLWDTMPEALQFNETWLQQETLLPDWPLEVMSTMLYAKVQSFLILLNRQRLERTQGAHSEPSPPGSMAPPPRPQPVMTSSMYGDQPLHPAPLRGRSLVVNSSIALVNAFMFFHYRRPQVLICWTMAQQCFNACMILILDAWETENENNLWLVNQAFAVFQQLDNNGVHKLAGLAVARISTGLAVLEQRRNERKQQAAASRGVSGYHPQLQIDTASMSDFQNDTVMGNTGMFLLEDTGLQSFDPMAFAPLGWNMAGSAHASSHSSHPTTPNIPSPMIPISQVTAAPFPVVTAPPYRSDGMMSAHLPSSYMHHQQQYYRPHLPTTTSGPGGRSHQAAFTPINNSTNNNMSLSASHQQQSSSSSTSSTSTSLSHQRHQLSPIEQAVVVAQHQQLRAPRHHHNSTNNSTNNSNSNNSGSNHHYHSSTKQNSHHHISSPRIGKSGAGAGGGGGGGGGGSRGILRPERISSSGSGRSSLVRRKGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-05-03" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M3CM39</accession>
    <name>M3CM39_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_148426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762969.1">
        <property type="nucleotide sequence ID" value="XM_016904921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CM39"/>
    <dbReference type="GeneID" id="27902058"/>
    <dbReference type="HOGENOM" id="CLU_1950170_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032440" evidence="1">
        <location>
            <begin position="19"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF14848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="129" mass="13559" checksum="EEDF77BCD5759647" modified="2013-05-01" version="1">MQYFTLASFVALVSLATADDGPGPTFTISPYGNGDTVCKASALLDPPGQFIVGPGDVGTSRQLPLDTSAVGFFYDPNSSPAYKIDYFVNPMCNGLPDYTEYPTIGESGCSVPAGAPWTCFQINAYPPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M3CMD9</accession>
    <name>M3CMD9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">3-isopropylmalate dehydrogenase</fullName>
            <ecNumber evidence="4 14">1.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SEPMUDRAFT_146967</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(2R,3S)-3-isopropylmalate + NAD(+) = 4-methyl-2-oxopentanoate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:32271"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.85"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="14">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="14">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="14">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 14">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.85" evidence="4 14"/>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF14958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763079.1">
        <property type="nucleotide sequence ID" value="XM_016903995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CMD9"/>
    <dbReference type="STRING" id="692275.M3CMD9"/>
    <dbReference type="GeneID" id="27901132"/>
    <dbReference type="eggNOG" id="KOG0786">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031953_0_3_1"/>
    <dbReference type="OMA" id="EYDLGAR"/>
    <dbReference type="OrthoDB" id="419183at2759"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00072"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003862">
        <property type="term" value="F:3-isopropylmalate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000006">
        <property type="entry name" value="3-isopropylmalate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004429">
        <property type="entry name" value="Isopropylmalate_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00169">
        <property type="entry name" value="leuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979:SF1">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12 14" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="5 14" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0520">NAD</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="15">
        <location>
            <begin position="5"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMF14958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="365" mass="38890" checksum="AB699D2696BA1BB5" modified="2013-05-01" version="1">MPTYNIVVFGGDHCGPEVTAEALKILDVVDKSNADVHFNIEQHALGGASIDAHGEPLTDAALAAAKAADAVILGAIGGPKWGTGKVRPEQGILKLRKEMGTYGNLRPCFFASESLVKSSPLKEEVCRGVNFNIVRELTGGIYFGERTEDDGSGYAMDTEPYSRAEIERVTRLAAHLALAEDPPVPVWSLDKANVLATSRLWRKTVTEVMDKEFPQLKYGHHLIDSAAMLMVKNPRALNGIIVTSNLFGDIISDEASVIPGSLGLLPSASLTASPDGKSKCNGIYEPIHGSAPDISGQGIVNPVAMILSLGMMFKYSLQQPELSKKIDEAVRNVIENGIKTKDIGGSAKTAEVGDAVAKELASLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M3CV76</accession>
    <name>M3CV76_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Family A G protein-coupled receptor-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_152348</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the archaeal/bacterial/fungal opsin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF08052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756173.1">
        <property type="nucleotide sequence ID" value="XM_016907390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CV76"/>
    <dbReference type="GeneID" id="27904527"/>
    <dbReference type="eggNOG" id="ENOG502QQVQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054785_2_1_1"/>
    <dbReference type="OMA" id="MPWPTIL"/>
    <dbReference type="OrthoDB" id="536545at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005216">
        <property type="term" value="F:monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007602">
        <property type="term" value="P:phototransduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15239">
        <property type="entry name" value="7tm_YRO2_fungal-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000160">
        <property type="entry name" value="Related to Opsin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001425">
        <property type="entry name" value="Arc/bac/fun_rhodopsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018229">
        <property type="entry name" value="Rhodopsin_retinal_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043476">
        <property type="entry name" value="Yro2-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286:SF1">
        <property type="entry name" value="30 KDA HEAT SHOCK PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01036">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00251">
        <property type="entry name" value="BACTRLOPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01021">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00950">
        <property type="entry name" value="BACTERIAL_OPSIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0157">Chromophore</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="10 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0681">Retinal protein</keyword>
    <keyword evidence="4" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF08052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="317" mass="34349" checksum="ABA9C306D5B4AA94" modified="2013-05-01" version="1">MVNNALNTNDGDVNNGVAQIAITTHGSDFYFAVCAVMTVSTFAFLALGQMKPRAERIFYYITASVTMVAAIAYFTMGSHLGFTPIDVEYQRSNSRVAGVNREIYYARYIDWVITTPLLLIDLMLTAAMPWPSILFVILVDEVMIITGLIGALVASSYKWGYFVFGCVALVYIVYVLVWEARKHANGVSSDAGKTFLYCGSLTAFLWILYPVAWGVSEGGNIIAPDSEAVFYGILDLLAKPLFGALLIWGHRNISPAQLGLTIHDYGGEDPVIHEKNTGISHGHTGHPGDNPANVGVMNGTHGTTTANGNTTYATNTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M3CVF9</accession>
    <name>M3CVF9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">40S ribosomal protein S9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_152410</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF08137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_016907430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CVF9"/>
    <dbReference type="STRING" id="692275.M3CVF9"/>
    <dbReference type="GeneID" id="27904567"/>
    <dbReference type="eggNOG" id="KOG3301">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_089738_0_0_1"/>
    <dbReference type="OMA" id="RQFITHG"/>
    <dbReference type="OrthoDB" id="1697570at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000021">
        <property type="entry name" value="40S ribosomal protein S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_uS4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005710">
        <property type="entry name" value="Ribosomal_uS4_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_uS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003139">
        <property type="entry name" value="PRK04051.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01018">
        <property type="entry name" value="uS4_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF5">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 11" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS4 N-terminal" evidence="10">
        <location>
            <begin position="5"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-binding S4" evidence="9">
        <location>
            <begin position="105"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="163"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF08137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="193" mass="22247" checksum="45C065A27D650479" modified="2013-05-01" version="1">MAPISYSKTYKVPRRPFEAARLDSELKIVGEYGLRNKREVWRVQLTLSKIRRAARQLLTMDEKDPKRLFEGNALIRRLVRVGVLDESRMKLDYVLALKIEDFLERRLQTCVYKLGLAKSIHHARVLIRQRHIRVGKQIVNVPSFIVRLDSQKHIDFALTSPFGGGRPGRVRRKKAKAAESKGDGDDAGEEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M3CXZ2</accession>
    <name>M3CXZ2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_159416</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756672.1">
        <property type="nucleotide sequence ID" value="XM_016907844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CXZ2"/>
    <dbReference type="STRING" id="692275.M3CXZ2"/>
    <dbReference type="GeneID" id="27904981"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_909640_0_0_1"/>
    <dbReference type="OrthoDB" id="10018191at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000110">
        <property type="entry name" value="Zinc finger protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF58">
        <property type="entry name" value="ZINC FINGER PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="175"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="225"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="177"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="264"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="280"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF08551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="306" mass="34531" checksum="AC3E8D5DF59E33AC" modified="2013-05-01" version="1">MTCTQMSKPYARPDAQSDSDDMDLGISSKEEPRNKAALVVMCDEENDLPPVAIVDPNRPHSCRICAKTFKSKHYMKRHEANHSGKKPWRCSECNKRFTEKSNAIKHQLLHSDNPKPWLCPVCKKTFTQKGNAQVHVKRVHGFDLLDIPKKEKQTMAVISNEGDLGDTFAVPRSAMDAVRKPSRPDKEGYAPPVGDLTLTPSPDRKRKLAQDWDVDSVLDYSKLASISPPNKRAKRDAKCKGKEKERKPSVSSSDHDSGFDEEYQSSPTESPQSNGSSLPRADDSDEDHRNFKFKFDYSRKPVAEME</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>M3CYW5</accession>
    <name>M3CYW5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_127606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF09854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757975.1">
        <property type="nucleotide sequence ID" value="XM_016902163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CYW5"/>
    <dbReference type="GeneID" id="27899300"/>
    <dbReference type="HOGENOM" id="CLU_2238294_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="105" mass="12231" checksum="4C670D7E287FCB7A" modified="2013-05-01" version="1">MPDISETRTRTRCCIMQTLGHAINPPRTFHEFEELQTTLPQQMIDIQPQRDHDALKTLSSYRHFLRARISMSERIADDSATADDRCSTSTRSRCEEDTSYVHEFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M3CZ39</accession>
    <name>M3CZ39_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Eukaryotic translation initiation factor 2A</fullName>
            <shortName evidence="8">eIF-2A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_151814</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the WD repeat EIF2A family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757037.1">
        <property type="nucleotide sequence ID" value="XM_016907062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CZ39"/>
    <dbReference type="STRING" id="692275.M3CZ39"/>
    <dbReference type="GeneID" id="27904199"/>
    <dbReference type="eggNOG" id="KOG2315">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013809_0_1_1"/>
    <dbReference type="OMA" id="RCCAYSP"/>
    <dbReference type="OrthoDB" id="2194683at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000596">
        <property type="entry name" value="Eukaryotic translation initiation factor 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011387">
        <property type="entry name" value="TIF2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017222">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Translation initiation factor beta propellor-like" evidence="10">
        <location>
            <begin position="217"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="482"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="534"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="608"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF08916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="693" mass="75442" checksum="2554DFBC0E866B90" modified="2013-05-01" version="1">MAAPTQLAFRTSKTVGVFDATPVYENLPGFERPEGNLRCCVYSPDGRFFAWASPESVTVIDSSVGHVVTTLPAENVYELGFSPLGTFIITWQRPSKDEEGNATKNLKVWRTIDDNAGEDGERAVVGKFVQKSQTGWNLQYSPDEQFCARCVTNEVQFYESKDLGTVWQKLRIEGVSDFALTQGKTHSVAVFIPERKGQPAAVKVFKVPEFGSPVSQKTFFKGDKVQLKWNQEGSSLIVLAQTEVDKSNKSYYGETNMYILSANGGFDSRITLDKEGPIHDVTWSPNSKEFGVVYGYMPAKTTIFNQRAIAQHSFNLGPRNTIIFSPHGRFVLVAGFGNLAGQMDIYDLEKNYEKVCTIEGSNTSVCEWSPDGKHILTATTSPRLRVDNGIRIWHVTGGLMYNEEHHELYHVIWRPATLPLENPLQAGPPHASALEFLGKMKTPSKPAGAYRPPGARGTATPLSFKREDEGGAAFVREMMSGKEQPAAFGPRAPRVRNVPGAEPVDPKQLPPGAAPGGGVALAQDGDENLSKAALKNKKKREAKKAKDAEAKANGLAPAQNGDVNGNSVEGEQRARSRSNAGNAKGSRPQSRRRDGAAPGRVPAAPMSMDTTPPKQTNGTPTQTVKPPEVEVTSPGIGGPNEKKIRSLLKKLRAIDDLKMRQAGGEKLEGTQVLKIGTEEQVRKELAAVGYHGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M3CZW2</accession>
    <name>M3CZW2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_13752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758300.1">
        <property type="nucleotide sequence ID" value="XM_016902841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CZW2"/>
    <dbReference type="STRING" id="692275.M3CZW2"/>
    <dbReference type="GeneID" id="27899978"/>
    <dbReference type="eggNOG" id="ENOG502S3Q3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044743_0_0_1"/>
    <dbReference type="OMA" id="CDGLIYS"/>
    <dbReference type="OrthoDB" id="441517at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF10179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="365" mass="40430" checksum="AC05921F23601F42" modified="2013-05-01" version="1" fragment="single">MSNGKPKVEIPAWQRAAQPTPAPVDDPVYSKPQQPEKESEMEADVKEGTVSSEEKDGGAEAAEGSVGTQKEDIARFQRVFGRDEFADFKQRQVEQRNTPPPQQQQQATHTAPPIITYPEFLVEAHKPPPLITPTRVLNTLYVAGGISTLLYAASKYIVTPMVDTLHESRHDFLSHSQSKVDELNSRLSKLVSKQPGGTIMPSDVDDDDSDLSDPTELYHRDMGTQTELPLEAKSTIRNVEEEKKKEHVEYAANGLKIIESHISEMADASDQAGEAHKDRREKMNELRHYLDQLLYGTAGGPLWTEDSIKNAYGTSSAMGGIGAMDSSNTNNNKKEDDAIEELKKEIRGVKGVLLSAKRFPPARRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M3D0K8</accession>
    <name>M3D0K8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_150078</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759174.1">
        <property type="nucleotide sequence ID" value="XM_016905953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D0K8"/>
    <dbReference type="STRING" id="692275.M3D0K8"/>
    <dbReference type="GeneID" id="27903090"/>
    <dbReference type="eggNOG" id="ENOG502QPK1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_46_1_1"/>
    <dbReference type="OMA" id="MIPAWIL"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000395">
        <property type="entry name" value="Carboxylic acid transporter protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000465">
        <property type="entry name" value="Carboxylic acid transporter protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF9">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORT PROTEIN (AFU_ORTHOLOGUE AFUA_2G09450)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="69"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF11053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="515" mass="55935" checksum="0A078C3701D01240" modified="2013-05-01" version="1">MESTGRPAEPIAVGVWATAKQSFSDLFKWEQRVKITNEYGESRTEWQRPLPLRNPISLLAQLTPTAWVFFIVGFASWTADAFDFHALSIQTTKLADYYDTTNTNITSAITLTLLLRSVGAAVFGLLGDQFGRKWPMVMNMIILGVLQIATIYSTTFSQFLAVRSIFGLFMGGVYGNAIAMALENCPVDARGLMSGILQQGYSFGYVCAACANLGVGGSTESWKTVFWIAAGLSIGVGLIRVGFPESQQFRERKAAGHKGASPGVFWKETKQMLAREWKMCIYCIVLMTWFNFYSHTSQDSYTTFMKTQKRMGNHDASIASILMKTGACVGGTIIGYLSQWVGRRRAMVVAALMSALMIPAWILPTSLGGLSASGFMIQFFIQGAWGVIPIHLNELSPPAFRSSFPGLTYQLGNMISSPSAQIVNAIAESHLIRPAGGQGKDVPSYGPVMGVATAIIALGIAVTAAVGPEKRGSKFENAVIGGQTTVDVEKLGDEEKGGNVEKGIKEIRLEEVERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M3D1F1</accession>
    <name>M3D1F1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial pyruvate carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_151292</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mediates the uptake of pyruvate into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758434.1">
        <property type="nucleotide sequence ID" value="XM_016906723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D1F1"/>
    <dbReference type="STRING" id="692275.M3D1F1"/>
    <dbReference type="GeneID" id="27903860"/>
    <dbReference type="eggNOG" id="KOG1590">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099502_3_0_1"/>
    <dbReference type="OMA" id="LMACHCT"/>
    <dbReference type="OrthoDB" id="1697690at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:7770001">
        <property type="term" value="C:mitochondrial pyruvate carrier complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050833">
        <property type="term" value="F:pyruvate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006850">
        <property type="term" value="P:pyruvate import into mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005336">
        <property type="entry name" value="MPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14154">
        <property type="entry name" value="UPF0041 BRAIN PROTEIN 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03650">
        <property type="entry name" value="MPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF10313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="156" mass="17003" checksum="C1FF6C4DBCC8BAC7" modified="2013-05-01" version="1">MAAMIKALNAKIRSNPTTDYLCSTHFWGPASNFGIPIAAVMDTQKDPEVISGPMTTALVGYSAVFMRYSMAVTPKNYLLFGCHLVNFSAQSVQGYRFINWWYMGGRDKSMEAKAKEGLKTAEGKIEGLVGQAQEKLGQAGGKVQGLAEQAKEKISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2022-12-14" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>M3D1W9</accession>
    <name>M3D1W9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_109227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759238.1">
        <property type="nucleotide sequence ID" value="XM_016900771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D1W9"/>
    <dbReference type="GeneID" id="27897908"/>
    <dbReference type="HOGENOM" id="CLU_1180858_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF11117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="235" mass="25770" checksum="AC16A6A3CD33BCF4" modified="2013-05-01" version="1">MDERRIWLLVTSQQLLAHLAEAGPSRPLWQHKIHVGHSGGGQPVANMWKLEKSTCKSISYLYHTGSRSCSVAPPDTATSYDADTSHSLVGGISDSTSHECIAMHLLVACVGSRRKYSSTDTRIFDLQVAIDIFEYQYTSTPVHLVHSSHSTSRHHPLASGPGQPQLGEHEHNLEAESPHIINTAPAPLASCRIKNDAQCNSWSRSVDSSTASDGTVACHTRLLIQHWLQPWASKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M3D4K2</accession>
    <name>M3D4K2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD_binding_1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_148524</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761266.1">
        <property type="nucleotide sequence ID" value="XM_016904974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D4K2"/>
    <dbReference type="STRING" id="692275.M3D4K2"/>
    <dbReference type="GeneID" id="27902111"/>
    <dbReference type="eggNOG" id="KOG1158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_17_5_1"/>
    <dbReference type="OMA" id="LCCGGGC"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030586">
        <property type="term" value="F:[methionine synthase] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050667">
        <property type="term" value="P:homocysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000007">
        <property type="entry name" value="Methionine synthase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF84">
        <property type="entry name" value="METHIONINE SYNTHASE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="6">
        <location>
            <begin position="259"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="67"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF13145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="725" mass="80482" checksum="1811FBD5AE7725D8" modified="2013-05-01" version="1">MSSLHPLARPANRRHSFSGFGKGLTLHRHKNIPHNETSDPTNPIPTEPRNTPGMNLTVEQKLRLSNLTSSMSTNPRSSGESLGFYTDDVHTSDSEAPSTPLTEPSDLVEDSIKSINSMSLSDEQSTMKKRRASTTYAGNVDDIRRLIGNGTGTKFLQKYCCGEGCCMIESLPLHTDEVAYAPIITPANDAYRSLNLDLRSLSLDTELTKLPDPPAQKVSFATIRRQSIVEKFPDESRHKHDADEVNEYPPEYMKPHPPYSIFNAPIYGARELTKPGAEKRTFHFDIDVTEYPEEGGVDFKVGGAIGICPPNDPAVVEDILNQLGVPRFQRDKAIRLRTNEGRWPTIWGDEEARELVSTRREILTWTVDISSTAPTKPVLSLLAEHASEPNEKKILQYLCSAQGQATFCDLRTGPHITLQQLLHAFPSSKPPLEALCGVLNQLMPRFYSLSNDPHVSSAREGLAGRRLIEMAVTIHETSNFDGRQRSGVGSGYMERIAKRFIEHDEKARKEADARGFMLQEGVAGRRLNLHVPMFRGLMSNPLSKKFNADGPMVLIGAGVGMAPFRGFILNRLKNANCANKIWLIQGIRDTMLDEIYKGELGAHEKDIKKVVQSRAKTLPPVAEDDDGVLDNADSDDPAKVVDPKKVDKVAKYVQDEVRQQADIVWYVINALDGRIFVCGSSKGMGEGVEAALIDVAMDKGNLDYETAKQFWESKTQAGQYIAETW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M3D551</accession>
    <name>M3D551_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cora-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_149515</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF13009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761130.1">
        <property type="nucleotide sequence ID" value="XM_016905601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D551"/>
    <dbReference type="STRING" id="692275.M3D551"/>
    <dbReference type="GeneID" id="27902738"/>
    <dbReference type="eggNOG" id="ENOG502QPTQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007127_10_0_1"/>
    <dbReference type="OMA" id="NEQWDIA"/>
    <dbReference type="OrthoDB" id="29879at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010961">
        <property type="term" value="P:intracellular magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12829">
        <property type="entry name" value="Alr1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000008">
        <property type="entry name" value="CorA family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000014">
        <property type="entry name" value="CorA family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044089">
        <property type="entry name" value="Alr1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535">
        <property type="entry name" value="MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535:SF51">
        <property type="entry name" value="MANGANESE RESISTANCE PROTEIN MNR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="869"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="301"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="451"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="702"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="116"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="301"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="336"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="453"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="702"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF13009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="897" mass="99755" checksum="A56F4B451BE4FAF2" modified="2013-05-01" version="1">MASRQPRGGLASIAGPASMAKPAPGEGQSDDATGSANAMGAPPNKKKKHRAGRKHRKPRRQSFIAPSEAATEDTTDMQDRPSLLEASHHASQRDSFYRVQNSTRRGSHTSLESEALLDHREHAPLSRRRDTMRQGFARAALPFARHQHRPSDASAKAGGGGGSGRSRPAHTEESVISEDEEDEHRGTERSPLLGNKARTKPHVSRANSGLQGGTHSSNGNTTRTRHESSPSKTSSPRGAPLEILTATRNPQPDGDHDVNNPPSVPGSPTLGITEDLYIYGLGSSLSERGRDAVIHISEDEADRELDNRSPESMRRRPTLAQLAERDVCFPGDDDATEHGEESPHASQREASVKPRRRRGRKFPDLEVLEEWSREEKEARTQQEVQRAKKISEPVMIGGRLRPAKTAWHAEAENSPFRFTYFNEMLDGTIHARTISDLQDDMTFHELFIPDPIELSDDSDDEDEHDEGAIERPTLHKLRRASSVGRSKHADAVSQNGDPPRPASIARGSIVESMANSKSAAESAPVSGGDSGNVTPKGQRKRYGPRPTFWLDVLSPTENEMKVLSKAFGIHQLTSEDILMNEQREKVELFPSYYFVNYRTFEQDKDSENYMEPINMYVIVFRDGVITFHHSMSPHPANVRRRIRQLSDYMSPTADWISYAIIDDVTDVYAPLVTEIEQEVDDIDEEILLMHQESDPNAIEQAKFEQKQKEGKAKGEKRRESNASATTIDAGKKKNSGGDMLRRVGGCRKKVMSLYRLLGNKADVIKGFAKRCNEHWEVAPRSEIGLYLGDIQDHIVTMTGNLSHYESLLSRAHGNYVAQINIRMNERAETNADVLGKLTVLGTIVLPMNIITGMWGMNVWVPGQEYEGDLSWFFAITAGLAAFGFICYFIAKKVYGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M3D5F2</accession>
    <name>M3D5F2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_124973</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761235.1">
        <property type="nucleotide sequence ID" value="XM_016901944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D5F2"/>
    <dbReference type="GeneID" id="27899081"/>
    <dbReference type="eggNOG" id="ENOG502SSIA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1361171_0_0_1"/>
    <dbReference type="OrthoDB" id="2426396at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032238" evidence="2">
        <location>
            <begin position="27"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF13114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="201" mass="20923" checksum="9EE7B9F3A969D21F" modified="2013-05-01" version="1">MHAPNAVRLRVVTTIFLALGAVPTLAQYVENFTGSLQIVNGQGTYSGTSSGGSGGWSESGSPAVQAQCPANFPVTCSSIQKPDYCCPANNYCAWQDSVVACCPNGKVCSGFAQPITTVWQQQPPATVVVVGAPSKPEGYFGQYCKTLVAVGPGLPTTEAGDCGTILIVEGDAIRATVINWIYAIGMVVGLQILGGLVFMRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M3D618</accession>
    <name>M3D618_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear speckle splicing regulatory protein 1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_84056</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NSRP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761440.1">
        <property type="nucleotide sequence ID" value="XM_016910344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D618"/>
    <dbReference type="STRING" id="692275.M3D618"/>
    <dbReference type="GeneID" id="27907481"/>
    <dbReference type="eggNOG" id="KOG2117">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042321_0_0_1"/>
    <dbReference type="OMA" id="MSKPLAF"/>
    <dbReference type="OrthoDB" id="446635at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053246">
        <property type="entry name" value="NS_splicing_regulatory_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018612">
        <property type="entry name" value="NSRP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47845">
        <property type="entry name" value="NUCLEAR SPECKLE SPLICING REGULATORY PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47845:SF1">
        <property type="entry name" value="NUCLEAR SPECKLE SPLICING REGULATORY PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09745">
        <property type="entry name" value="NSRP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nuclear speckle splicing regulatory protein 1 N-terminal" evidence="4">
        <location>
            <begin position="100"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="151"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="297"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="153"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="233"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="305"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="328"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="391"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF13319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="400" mass="44674" checksum="2158B3DDA885989E" modified="2013-05-01" version="1">MSLKYGLNVKKKGPPPPRRTLLDDEDGDDDDDGLQQSGPAEAAIEEITTFGGSSNSATTKSTSQSTPALGLTKTKPKGIPARPHDNDEARQDLSALRAAENRVKDAEKADSSIFDYDSFHDAKTSVTEAKKAALKEDAIARKPKYINNLLESASRRKQDQQIAREKLLQKEREAEGDEFADKEKFVTSAYKAQQEETRKLEEEEKRKAEEEEKRRGNKLVGGMAGFYRTMMDQSERQHQEAVEAAEKAEREGVKIADEDRKKTDAELAEEAKARGKNIHVNEEGQITDKRELLSAGLNIVPSGKGSDKRAADHLKSSNRPAQSAFPTRKHDAQQATRERQSKLMEEQLAERLKRQREEEEEERAKLERAAKSTKTATDVNDAKARYLARKAAKEKEKAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M3D7H2</accession>
    <name>M3D7H2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_148990</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761945.1">
        <property type="nucleotide sequence ID" value="XM_016905270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D7H2"/>
    <dbReference type="STRING" id="692275.M3D7H2"/>
    <dbReference type="ESTHER" id="sphms-m3d7h2">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="GeneID" id="27902407"/>
    <dbReference type="eggNOG" id="KOG4389">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006586_10_6_1"/>
    <dbReference type="OMA" id="ETWAANG"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005140300" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="21"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="38"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF13824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="579" mass="63567" checksum="5D514FF3BF4BC272" modified="2013-05-01" version="1">MPAITSILSTAAAFVGLGLAIPHSSITARQLATRSDASPSVTVKNGTIAGIHQPDYNQDFFLGIPFAQPPLEQLRFRNPQSINASYDGVFQATEYAPMCYGYGGDQIGYPQSEDCLYLNVVRPSGYENQSLPVGVWIHGGGLYQGGSRDDRYNLTFIVENAVRIGKPFIAVSIAYRLGPWGFLQSEEVSTSGDTNIGLRDQRLALHWLHENIDAFGGDCRKVTIWGESAGAGSVGWHITAYGGRDDGLFRAGIMQSGNPVPYNGYETLAKYQPQYDALVDATNCTMAADTLTCLREVPSDSLAQLFSDTSSLNEGWRPIVDGDFIQRLASAQLAEGAFVKVPILTGANTDEGTAFGPQGIDTDDQFRSYVADRTENPYIPEDLADEVLAAYPNTPAYFIPPVENIGNYTFPASYGAQYRRAAAYAGDVTFIAHRRGASETWAANGLAAYSYRFNTVPAGIDFYVGATHFQEVAFVFNNTLGLGYNEEHGTVNPFLNKSQSYYDLAAHMSKSWASFIYDSDPNYEVSWPESAPAWPQYSLDKPENIVWDANVSALAFVEPDTFREEGIRWILDHAEEYNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M3D7L1</accession>
    <name>M3D7L1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Glucose-6-phosphate isomerase</fullName>
            <ecNumber evidence="3 10">5.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_149014</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the GPI family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.9" evidence="3 10"/>
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        <property type="protein sequence ID" value="EMF13869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016905284.1"/>
    </dbReference>
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    <dbReference type="STRING" id="692275.M3D7L1"/>
    <dbReference type="GeneID" id="27902421"/>
    <dbReference type="eggNOG" id="KOG2446">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017947_3_0_1"/>
    <dbReference type="OMA" id="DWYRQLW"/>
    <dbReference type="OrthoDB" id="5831190at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00181"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:glucose-6-phosphate 1-epimerase activity"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:canonical glycolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00473">
        <property type="entry name" value="G6P_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023096">
        <property type="entry name" value="G6P_Isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018189">
        <property type="entry name" value="Phosphoglucose_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035476">
        <property type="entry name" value="SIS_PGI_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035482">
        <property type="entry name" value="SIS_PGI_2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001211">
        <property type="entry name" value="PRK00179.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469:SF1">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00662">
        <property type="entry name" value="G6PISOMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00765">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00174">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="6 10" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 10 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF13869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="552" mass="61347" checksum="839A8895A1CCA98E" modified="2013-05-01" version="1">MPGFAQANELPAWKALMEHHDKLGRGMVLKSEFEKDPQRFEKYSHTFHNEADNSDILFDFSKNFITDDTLPLLVKLAQEAKLESLRDDMFKGEKINFTEQRAVYHVALRNVKNEPMQVDGKSVVEEVNSVLDHMKEFSEQVRSGEWKGYTGKPIDTIINIGIGGSDLGPVMVTEALKPYGKKGMKLHFVSNIDGTHIAEALEGSDRETTLFLIASKTFTTAETVTNATTAKNWFLEKAKQEDVAKHFVALSTNDKEVSKFGIDTKNMFGFNDWVGGRYSVWSAIGLSVALYIGFDNFKEFLAGAQSMDHHFRTAPLEQNIPVIGGLLSVWYSDFFGAQTHLVSPFDQYMHRFPAYLQQLSMESNGKAITRSGDYVKYTTGAILFGEPCTNAQHSFFQLLHQGTKLIPADFIIAAKSHNPVENNKHQHMLASNYFAQAEALMIGKTPDTVKNEGAAAELVPHKVFLGNRPTTSILADKITPGTLGALIAYYEHVTFTEGAVWNINSFDQWGVELGKALAKNIQSELDNAGQSTKHDSSTSGLINAFKKKAGIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M3D7V2</accession>
    <name>M3D7V2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carbohydrate esterase family 5 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_41716</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762055.1">
        <property type="nucleotide sequence ID" value="XM_016908843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D7V2"/>
    <dbReference type="STRING" id="692275.M3D7V2"/>
    <dbReference type="GeneID" id="27905980"/>
    <dbReference type="eggNOG" id="ENOG502S6TR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040058_6_1_1"/>
    <dbReference type="OMA" id="HKSGLAC"/>
    <dbReference type="OrthoDB" id="3225429at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630:SF9">
        <property type="entry name" value="CUTINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630">
        <property type="entry name" value="CUTINASE RV1984C-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032385" evidence="3">
        <location>
            <begin position="24"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF13934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="244" mass="25702" checksum="9DFF592EDFECED9F" modified="2013-05-01" version="1">MIATHPCTLLLTLACSSAVTATAAVMKKSEKRQTSTCSSYTIINTRGTGEPPGPCPEFLTMNQNILSQLPGGKVYNTNYRAALDQISEYGTDDIISYIRTTLQSQPNECFILQGYSQGASATISALSSLSSSSEDGDGDAVKAVFLVGNPSRQPGLECNVDNFGEGSTRDSRGILGVWGNGKGGIEGGWVERTRDVCISGDGICDSLHGFGLTPQHLSYGSDEATQKLGTEFIISQLQGGGMLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>M3DAJ1</accession>
    <name>M3DAJ1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_105417</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763236.1">
        <property type="nucleotide sequence ID" value="XM_016900577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DAJ1"/>
    <dbReference type="GeneID" id="27897714"/>
    <dbReference type="HOGENOM" id="CLU_1687794_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF15115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="156" mass="17670" checksum="D3ADF1353A80EC0F" modified="2013-05-01" version="1">MWLFVQRSGLGHHIGSGRLCDHENTHPYACCKDVGGHHLKKEQIDRVATVMATIFVSGLTEQCQKLTPAADPRTRHQSWQYGSFTTPPNAARSMQSIAARETVPHWQRFDDNDTQYLTLRYEAIKSGKSHMELMRRTVAAQDWPIHITAMIATSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M3DCL6</accession>
    <name>M3DCL6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_154349</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763675.1">
        <property type="nucleotide sequence ID" value="XM_016907557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DCL6"/>
    <dbReference type="GeneID" id="27904694"/>
    <dbReference type="HOGENOM" id="CLU_886143_0_0_1"/>
    <dbReference type="OrthoDB" id="3621950at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF15554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="34524" checksum="631831A70D1C940B" modified="2013-05-01" version="1">MSFGQSIPVSGQILPIRVSVWSHSSTANVHLMIPIGESPRQCGMDAILLMKSKKRRSIGDDCRRIQVTYTVGGTLSNVLMDLPVSPGADNEVHNASPLPLPPSSPGSGSRVASIYELLEMIILDLPLRELLLLRAVGRSFQRVVDTSEHIGLRFSLPLSSLKLRVGDYVRHPLLPREVDVWAGKTRKSHVNGAEGGGDRGGGGYVTCRFVLKQNANFDWSAPASWRNFYACGPRARSMRAWTGCSKVFGRRNTGEYRFYQSPRGLTLGQLADAACAMKTDAQVDDAIVHFETDLDDDGNDVPNEACSQYTKYWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M3DD05</accession>
    <name>M3DD05_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Elongation factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_60822</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763820.1">
        <property type="nucleotide sequence ID" value="XM_016909540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DD05"/>
    <dbReference type="STRING" id="692275.M3DD05"/>
    <dbReference type="GeneID" id="27906677"/>
    <dbReference type="eggNOG" id="KOG0469">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002794_11_2_1"/>
    <dbReference type="OMA" id="ASWNTEN"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01681">
        <property type="entry name" value="aeEF2_snRNP_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04096">
        <property type="entry name" value="eEF2_snRNP_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01885">
        <property type="entry name" value="EF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16261">
        <property type="entry name" value="EF2_snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1430.10:FF:000003">
        <property type="entry name" value="Elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000010">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000006">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000003">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000058">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF10">
        <property type="entry name" value="EUKARYOTIC TRANSLATION ELONGATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="17"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF15699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="842" mass="93473" checksum="B5671B0407C06554" modified="2013-05-01" version="1">MVNFTVEEIRGLMDDPKNIRNMSVIAHVDHGKSTLTDSLVQRAGIISAKNAGSARFTDTRPDEQERGVTIKSTAISLYGTLAEVEDLKDIVITTDKSEKNDFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCVQTETVLRQALGERIKPVVIINKVDRALLELQLSKEDLFQNFARVIESVNVVISTYYDKALGDVQVYPEKGTVAFGSGLHGWAFTIRQFAVKYAKKFGVDKNKMMERLWGESYFNAKTKKWTKNPEGAERAFNQFCLDPIFRIFDNIMNFKKEETPKLLEKLEVKLVGDEKDLEGKQLLKVVMRKFLPAADALMEMMILHLPSPATAQRYRMETLYEGPPDDVSAIGIRDCDPKGPLMLYVSKMVPTSDKGRFYAFGRVFSGTARSGLKVRIQGPNYQPGSKSDLFIKSIQRTILMMGRYTDPIEDVPAGNILGLVGIDQFLLKSGTLTTDETSHNLKVMKFSVSPVVQRSVEVKNANDLPKLVEGLKRLSKSDPCVLTFISESGEHVVAGAGELHLEICLKDLEEDHAGVPLRISDPVVQYRETVGGDSSMTALSKSPNKHNRLYMIATPMAEEVSKDIESGKIGPRDDFKARARILADDHGWDVTDARKIWCFGPDTNGANLLVDQTKAVQYLSEIKDSVVSGFQWATKEGPVAEEPMRNVRFNIMDVTLHADAIHRGGGQLIPTARRVLYAATLLADPGLLEPVFLVEIQVPEQAMGGIYGVLTRRRGHVFEEAQRPGTPLFNIKAYLPVNESFGFNADLRSNTSGQAFPQSVFDHWQILPGGSVLDPATNPGKVVEDMRKRKGLKPQVPGYENYYDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDF0</accession>
    <name>N1QDF0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Chorismate mutase</fullName>
            <ecNumber evidence="4 13">5.4.99.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SEPMUDRAFT_151424</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>chorismate = prephenate</text>
            <dbReference type="Rhea" id="RHEA:13897"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="5.4.99.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:13898"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; prephenate biosynthesis; prephenate from chorismate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="5.4.99.5" evidence="4 13"/>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757507.1">
        <property type="nucleotide sequence ID" value="XM_016906813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QDF0"/>
    <dbReference type="STRING" id="692275.N1QDF0"/>
    <dbReference type="GeneID" id="27903950"/>
    <dbReference type="eggNOG" id="KOG0795">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057757_0_0_1"/>
    <dbReference type="OMA" id="ATCDVNC"/>
    <dbReference type="OrthoDB" id="191918at2759"/>
    <dbReference type="UniPathway" id="UPA00120">
        <property type="reaction ID" value="UER00203"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072545">
        <property type="term" value="F:L-tyrosine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120284">
        <property type="term" value="F:tryptophan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.590.10:FF:000002">
        <property type="entry name" value="Chorismate mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.590.10">
        <property type="entry name" value="Chorismate mutase, AroQ class superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036263">
        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008238">
        <property type="entry name" value="Chorismate_mutase_AroQ_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037039">
        <property type="entry name" value="CM_AroQ_sf_eucaryotic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002701">
        <property type="entry name" value="CM_II_prokaryot"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01802">
        <property type="entry name" value="CM_pl-yst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21145">
        <property type="entry name" value="CHORISMATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21145:SF12">
        <property type="entry name" value="CHORISMATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01817">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017318">
        <property type="entry name" value="Chor_mut_AroQ_eu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="Chorismate mutase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51169">
        <property type="entry name" value="CHORISMATE_MUT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 13" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0827">Tyrosine biosynthesis</keyword>
    <feature type="domain" description="Chorismate mutase" evidence="14">
        <location>
            <begin position="147"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR017318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMF09386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="267" mass="30636" checksum="AB830F71B89B46FC" modified="2013-06-26" version="1">MDHAIDLSDPQKALSLAHIRYQLIRCEDTVLFHMIERAQFPLNNTIYRPGAIAIPGSDLSFSDWVLREQERLQSRIRRYQSPDEYPFFPDAMEDLILPPLEYPKILWENDVNVNDDLKSRYINSILPGVCPTREREENSRDAQENYGSAATADVNCLQSLSRRIHFGKFVAESKFRENPEKFVKLIKAGDTKGIDEAITNAAVEAQVLKRLRIKAEMYGNDPTLDAEAPKKIPVDAVVAMYKDHVIPLTKVVEVDYLMQRLKGSEWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDK0</accession>
    <name>N1QDK0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GDA1_CD39-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_151505</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757642.1">
        <property type="nucleotide sequence ID" value="XM_016906859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QDK0"/>
    <dbReference type="STRING" id="692275.N1QDK0"/>
    <dbReference type="GeneID" id="27903996"/>
    <dbReference type="eggNOG" id="KOG1386">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010246_3_0_1"/>
    <dbReference type="OMA" id="TAYEVCF"/>
    <dbReference type="OrthoDB" id="6372431at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004382">
        <property type="term" value="F:GDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045134">
        <property type="term" value="F:UDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046036">
        <property type="term" value="P:CTP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006256">
        <property type="term" value="P:UDP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24039">
        <property type="entry name" value="ASKHA_NBD_YND1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="ADENOSINE/GUANOSINE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782:SF121">
        <property type="entry name" value="NUCLEOSIDE-DIPHOSPHATASE MIG-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01238">
        <property type="entry name" value="GDA1_CD39_NTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="529"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="613"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="672"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="618"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="182"/>
            <end position="186"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF09521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="726" mass="79852" checksum="B63B183F1E77122A" modified="2013-06-26" version="1">MGKHRYGLVFDAGSSGTRVYVYKWDSAEHVLKKGHEKKLQSLPDIKTDKEWIKKVHPGISTFGDRPESVGPDHLKELVDFALDIVPKKDVESTPIFLLATAGMRLLPDHQRAALLEHTCSYFQRNTKFQLPDCGVHVQVIPGETEGLYGWIAANYLLGGFDKPDVHVHGKDHHTYGFLDMGGASAQIAFAPNATEAEKHADDLKLLRLRKVNGESLEYRVFVTTWLGFGANEARRRYVTRLLEASPGVDELPDPCLPVGIKVKKTGEELEPGSKDIALAEPHLIGTGDFTECLKSTYPLLEKEKECTDTPCLLNGQHTPAIDFDVNHFVGVSEYWHTTHEIFAMAHKDKAYDFASYQKQVTQFCSRKWIDIEKDVAKETWGHKVDEKTVEEVCFKASWLINMLHDGIGIPRVGIEASKGGAGNKTKAIVSSAKDHGFVDPFQAVDKIDGKELSWTLGKIVLYASSQIPAIDETKVVGFGSNVESSTAVPYDWQSPAGSLQPLPANGTGSLQNGDDWHDRILSSNYGRRGPGIIIFLLIFAVAVYLLCGRERRQSWYQKVTGGKRPGGGKPLRPKANRFLGGKLFGGSPTYERVLEEGNDNEYDDFELADVSDGERLSDSSLDSALDSTRAGRTSGMATPGLRGLSPDIARGSPKISKGYFDTPAVGAERVGSSHGLGIANPPTPFERGGLIIRTESKESLRAPSRSRRNSPTRRSPLMSPLKESVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-12-14" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDS4</accession>
    <name>N1QDS4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_151630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757821.1">
        <property type="nucleotide sequence ID" value="XM_016906938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QDS4"/>
    <dbReference type="GeneID" id="27904075"/>
    <dbReference type="HOGENOM" id="CLU_2185591_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF09700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="109" mass="12209" checksum="E990BC3C40067887" modified="2013-06-26" version="1">MQQQQQPFELTSYNQFPRALDLISLDPQQILQINISSQSEIACGTGLTSPESRMQLRDSSLRISQSITTSRSVGRSMAGMKSTFWTNSTLIIPFSARSNDYVPYGNLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>N1QE76</accession>
    <name>N1QE76_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_110722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757318.1">
        <property type="nucleotide sequence ID" value="XM_016900863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QE76"/>
    <dbReference type="GeneID" id="27898000"/>
    <dbReference type="eggNOG" id="ENOG502R93M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_987543_0_0_1"/>
    <dbReference type="OrthoDB" id="3640311at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="282" mass="31219" checksum="9966D0939D1F2ED4" modified="2013-06-26" version="1">MTDSDSDSGQSQQLQVVLSKPLRLAISKVGISTSTSTTTSTATTTKTSDSHLKSYKLKAGRMARKKIPVFPRFGQSTTSLLSPSPSSSSSSSSSSPSQQPLQFPPTTHNHHRPSTTHLIPTLAPHWYNTTAHLGDPCTSFSLDHILSCGHKILTFSPEPCARNCHARTVPDWEQPRDVGQGFACVACVVEHLGLRREVRWREYVGELLLMGKGGGVLVERRRGMRDERAWIEEKLGFVGLAWRDEDVEEMRRLCAKGKACIAPWIDPDYQEVVDLALRGARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>N1QET9</accession>
    <name>N1QET9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_117647</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759789.1">
        <property type="nucleotide sequence ID" value="XM_016901357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QET9"/>
    <dbReference type="GeneID" id="27898494"/>
    <dbReference type="HOGENOM" id="CLU_1403240_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF11668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="194" mass="21119" checksum="610D87630A26A521" modified="2013-06-26" version="1">MTSFTTIDLEFGAAARQAWHPSEKRASSGPAPAPAPAPVDGSIARVHAMARVRLVHVRVLAAFTSTLMGALSTGHVALRQKKASLGGMRKSPAGHGPRTILSAQQVGPDFPLFSSHQIPIPAEDLESLVLGPPQPKHDPYQACIALTMRRRRTFLSRDSEESAFARPSEEWDLHDANALVEGQRFWLEAMTDHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>N1QF30</accession>
    <name>N1QF30_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="5">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_151616</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="5"/>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757803.1">
        <property type="nucleotide sequence ID" value="XM_016906929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QF30"/>
    <dbReference type="STRING" id="692275.N1QF30"/>
    <dbReference type="GeneID" id="27904066"/>
    <dbReference type="eggNOG" id="KOG0373">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004962_8_3_1"/>
    <dbReference type="OMA" id="ETGSMNY"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060237">
        <property type="term" value="P:regulation of fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903432">
        <property type="term" value="P:regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="7">
        <location>
            <begin position="257"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="93"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="93"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="150"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF09682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="455" mass="50213" checksum="74BADE200E335AAB" modified="2013-06-26" version="1">MARERDSDVPQPGPATLSSHAGPDEWLEQAKLCHYLPEADMKRLCEIVKECLMEESNIQPVEAPVTVCGDIHGQFYDLLELFHVAGGMPGEVDQRAAEKAAQERDAPKKGKRSSMSSGTTAINAADIEPPTQITDPKVQRKMKRRFQRDSAYTSAASEDGSQTGEEGDEERGRVRSRSVGEDNEGVDDDDASEDSGVGVRSPGPSRSKSAAKKADQATGLQNFIFLGDFVDRGYFSLETFTLLMCLKAKYPDKVTLVRGNHESRQITQVYGFYEECQQKYGNASVWKSCCQVFDFLALAAIIDGKVLCVHGGLSPEIRTLDQIRVVARAQEIPHEGAFCDLVWSDPEDVVTWAVSPRGAGWLFGDKVSSEFNHVNGLSLIARAHQLVNEGYKYHFASQDVVTVWSAPNYCYRCGNVASIMTLGEDLEPDFKIFSAVPDHRRAVPAGRQGRGEYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFB3</accession>
    <name>N1QFB3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glc8 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_149731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759998.1">
        <property type="nucleotide sequence ID" value="XM_016905735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QFB3"/>
    <dbReference type="STRING" id="692275.N1QFB3"/>
    <dbReference type="GeneID" id="27902872"/>
    <dbReference type="eggNOG" id="ENOG502S2VH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070379_0_0_1"/>
    <dbReference type="OMA" id="SHKSEKH"/>
    <dbReference type="OrthoDB" id="551302at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007062">
        <property type="entry name" value="PPI-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12398:SF20">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY INHIBITOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12398">
        <property type="entry name" value="PROTEIN PHOSPHATASE INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04979">
        <property type="entry name" value="IPP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF11877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="272" mass="30770" checksum="B265E9A5159C3801" modified="2013-06-26" version="1">MAQTAPLQQSPGSLPHRPKGILKNSSSYHTSPNSRVSPERRSFSNNSDDTADQTRPGMPPRELSEKEITQMNTEANAGAHRRSSSNPQRNSLGRRLSSPAHNGDHPQDGEQQRLKWDEANLYLNEGQMGGKMKIDEPKTPFAGRYDPGEDEDEIESINAQELAVDELDMKPRARKASGSRAKEGDIPDIDLGEPEMEPIARRESDTERRVHVDPDEMDHDGGSHGEHNEADMTSEEREKHHKFEEMRKKHYEMKNIKSLLGHPEELDRLDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2023-02-22" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFM1</accession>
    <name>N1QFM1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_117978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760148.1">
        <property type="nucleotide sequence ID" value="XM_016901391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QFM1"/>
    <dbReference type="GeneID" id="27898528"/>
    <dbReference type="HOGENOM" id="CLU_1200451_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF12027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="231" mass="24672" checksum="5FE11088A9B7B70E" modified="2013-06-26" version="1">MAKERALTKCSGKSEHLENLTSSHFQRGPAICLSSTNLTGGQRIKLQVIVEPLVYRPRSRPWPPARQSRGAEHTYGVHITSDAARASRPGPSPQEPGTTNGISSRLTATAPLQEPAVSPQFRDESAPPAMDYSANVSRAIAPKQASKPKISLSRSGSGKCKSILPLLGVNPADSREMLGVLAMLGICDQELKCTALHHAISLAYVLGCIQIARYASRTGSQPQLPVEVMAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFY5</accession>
    <name>N1QFY5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">V-ATPase proteolipid subunit C-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_151471</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10 11">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757569.1">
        <property type="nucleotide sequence ID" value="XM_016906838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QFY5"/>
    <dbReference type="STRING" id="692275.N1QFY5"/>
    <dbReference type="GeneID" id="27903975"/>
    <dbReference type="eggNOG" id="KOG0233">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085752_0_1_1"/>
    <dbReference type="OMA" id="TSPYMWG"/>
    <dbReference type="OrthoDB" id="10264021at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008553">
        <property type="term" value="F:P-type proton-exporting transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18177">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6F_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18178">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6F_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000002">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="5"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="49"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="132"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF09448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="203" mass="20628" checksum="E0B3E811636211A5" modified="2013-06-26" version="1">MGGLYYGAGGAGSALTVIGLYMLFQGEGEAFNVGAFLESISPYAWASTGIALCIGLSVVGAAWGIFITGSSILGGGVKAPRIRTKNLISIIFCEVVAIYGVIMSIVFSAKMENVSGPGIYSAGNYFTGYALFWSGLLVGACNLICGVSVGINGSSAALSDAADPSLFVKVLVIEIFSSVLGLFGLIIGLLLSGNADPFQAPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFZ9</accession>
    <name>N1QFZ9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">High-temperature-induced dauer-formation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_149941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760328.1">
        <property type="nucleotide sequence ID" value="XM_016905867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QFZ9"/>
    <dbReference type="STRING" id="692275.N1QFZ9"/>
    <dbReference type="GeneID" id="27903004"/>
    <dbReference type="eggNOG" id="KOG2226">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007392_0_0_1"/>
    <dbReference type="OMA" id="TANSGWM"/>
    <dbReference type="OrthoDB" id="432953at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000138">
        <property type="term" value="C:Golgi trans cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026705">
        <property type="entry name" value="Hid-1/Ecm30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575:SF12">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12722">
        <property type="entry name" value="Hid1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="597"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="762"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="640"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="671"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="776"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="794"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF12207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="923" mass="102887" checksum="90151D037A7D0E97" modified="2013-06-26" version="1">MGVSESKIAFKQSVFKLIGDKVLQPDDDIFTTYWTVPERVDDVFDLLVGADVRVLTCTDASELGGAKAIPGEQCSPMTNLETLLYNAVAQLRRLQQDVAQPNELVVRQILNCMRILTRIMPFIFEAEHLRDWYDRFFWQPRKPQYLKWDDKRDAPTQLFDGLEPSRLYEKADQHKEIGPPLGETLLSLVIDYFFWRGLTLPALRDENRLSGRGYELKVWKTGIGCSSDPKCTAEHERNQYELVRFLLTLTSSPLYMRPDQVAVANNKVLTYLTTKVDKRVVNAINCSCLNTVMRFNPNLWSMPSGWQGARDNKKLLVLNCVQFLLVAMVYIPPEGKNGFRSSIGALFRPDDFQFIHHGTNVVISQPLTASNFSIGKSNAVHHATEMISFLWELIQCNKRFRRYLCETKVGMDYLVVLLYYARDSVGDEMKQGVMRMAIFVIQSLSAETAFTSKLNTPFLHVGSLPPVMRVENFRGSYADFLICSIHLLITTSKGRLEPVYPALFDIIKNVAPYAKNLQRATSSKVMNLFDIVSAPGFCLRNESNHLILKKVLDACYAILDNHSRENPQFVKVLVASKKRFTALRDLTVEGAQAELERQAIERKDRGDTSRGSSIDSMRRPAPLRTSSLAEVPEDSQFTIGDDDDNDDNHDDNHEDNEDEETDAEVSEKSTADSSQGTCSATDNTIAASPARLSDKARGKQPAAALRVSTSRNPSLTSLSTLTPVTTSQTFLPSEQWLANWSTQLPLDAILNVIEEAEKSPLGFTPITAPRQEHHANLSTTAPETQPSSRREARQSAQFTRHSAESSRSSQAAHGTDGQGHLSSKEDIRPAAGGPVNFSWTAVAIGWYNALIWSRIYVQEAEAFQGSGGLYSSTDIKLFRRQGASQEISLRSPKGAIDAVGLSLANRISSINLPDALGGGGHGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGL6</accession>
    <name>N1QGL6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lytic polysaccharide monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_10541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759740.1">
        <property type="nucleotide sequence ID" value="XM_016900576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGL6"/>
    <dbReference type="STRING" id="692275.N1QGL6"/>
    <dbReference type="GeneID" id="27897713"/>
    <dbReference type="eggNOG" id="ENOG502S005">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032571_2_3_1"/>
    <dbReference type="OMA" id="PHKGGSC"/>
    <dbReference type="OrthoDB" id="2342176at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182:SF2">
        <property type="entry name" value="LYTIC POLYSACCHARIDE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF11619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="21881" checksum="EF599A9333F516BC" modified="2013-06-26" version="1" fragment="single">MFISSPNPIEGTDSKSPLDPSGSQFPCQGATLPTRGGQIMAAGSTHLLAFNLGAGDNTAVHGGGSCQLSITYETDPRKQKDPSSWRVIYSIEGGCPTDAPGNLQQGHVVDCSTNGSTTTACVNEFPFTIPPGVKNGHAIMAWTWFNTIGNREMYMNCMNVELTGGDGSEVPDFPELFVANQGHLGNYCPTTERFNVKFPKPGEYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGL8</accession>
    <name>N1QGL8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-binding protein RAP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_55516</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the regulation of telomere length, clustering and has a specific role in telomere position effect (TPE).</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Chromosome</location>
            <location evidence="8">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the RAP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764436.1">
        <property type="nucleotide sequence ID" value="XM_016909364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGL8"/>
    <dbReference type="STRING" id="692275.N1QGL8"/>
    <dbReference type="GeneID" id="27906501"/>
    <dbReference type="eggNOG" id="ENOG502S85C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006783_2_0_1"/>
    <dbReference type="OMA" id="FQGARFW"/>
    <dbReference type="OrthoDB" id="435460at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070187">
        <property type="term" value="C:shelterin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031848">
        <property type="term" value="P:protection from non-homologous end joining at telomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010833">
        <property type="term" value="P:telomere maintenance via telomere lengthening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11655">
        <property type="entry name" value="rap1_myb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021661">
        <property type="entry name" value="Rap1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038104">
        <property type="entry name" value="Rap1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039595">
        <property type="entry name" value="TE2IP/Rap1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015010">
        <property type="entry name" value="TERF2IP_Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16466">
        <property type="entry name" value="TELOMERE REPEAT-BINDING FACTOR 2-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16466:SF6">
        <property type="entry name" value="TELOMERIC REPEAT-BINDING FACTOR 2-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08914">
        <property type="entry name" value="Myb_Rap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11626">
        <property type="entry name" value="Rap1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="2 8" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0779">Telomere</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BRCT" evidence="12">
        <location>
            <begin position="16"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="TERF2-interacting telomeric protein 1 Myb" evidence="10">
        <location>
            <begin position="114"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="TRF2-interacting telomeric protein/Rap1 C-terminal" evidence="11">
        <location>
            <begin position="332"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="168"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="303"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF11626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF16315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="419" mass="45684" checksum="D608D6CA8E906061" modified="2013-06-26" version="1">MSNASSTAPGNTVGSLFTGLKFFLVHKLPARTQLIADIEANGGSVVRLEKQADFVIADHARRDAPTGSYSWKLISTAIEDGAMPDPADYPAGPPPGTVRDIASGVPGKSKRTAFTLEDDKELWQWVQEQAPGGYGVKGNEIYRRLEQRNPRHTMQAWRDRYMKKLMDHPPAGINLTVPARPPPSPPTALDEQGSTHGIRTPPVKRRRVEASTEQAVGVGDDPDAQSANGESEASNEELASNTTPERYATKDHSAANFSVVQVKANESGQVDSDISTSDANQAATRQIMSLLPIESIEYHASRTQDTPATATESSKNSEEDEAAELESWMATMKVRGHDDNLVIEALKCTSMNLGLAELVLMHVKGGKGIPDDVPGVWTHEEDEQVEGGNARALRVLETKHGWPACTARLRFLERYRNED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGP2</accession>
    <name>N1QGP2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Eukaryotic translation initiation factor 1A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 4C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_21423</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 9">Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the eIF-1A family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764466.1">
        <property type="nucleotide sequence ID" value="XM_016908337.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGP2"/>
    <dbReference type="STRING" id="692275.N1QGP2"/>
    <dbReference type="GeneID" id="27905474"/>
    <dbReference type="eggNOG" id="KOG3403">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109098_0_1_1"/>
    <dbReference type="OMA" id="RRVMMHA"/>
    <dbReference type="OrthoDB" id="274995at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05793">
        <property type="entry name" value="S1_IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000071">
        <property type="entry name" value="Eukaryotic translation initiation factor 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00216">
        <property type="entry name" value="aIF_1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001253">
        <property type="entry name" value="TIF_eIF-1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018104">
        <property type="entry name" value="TIF_eIF-1A_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00523">
        <property type="entry name" value="eIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21668">
        <property type="entry name" value="EIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00652">
        <property type="entry name" value="eIF1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01262">
        <property type="entry name" value="IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1-like" evidence="11">
        <location>
            <begin position="15"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="106"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="115"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF16345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="143" mass="16128" checksum="125446C11FF1C359" modified="2013-06-26" version="1" fragment="single">GGKNRRRGKNENDNEKRELTFKEEGQEYAQVLKMLGNGRLEAYCFDGSKRLAHIRGKLRKKVWINQGDIILLSLRDYQDEKGDVILKYSADEARSLKAYGELPDSAKINETDTYGGDEEGGIGFDFGEDDDSESGEDVDIDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGQ0</accession>
    <name>N1QGQ0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C6 transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_129313</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764476.1">
        <property type="nucleotide sequence ID" value="XM_016902279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGQ0"/>
    <dbReference type="STRING" id="692275.N1QGQ0"/>
    <dbReference type="GeneID" id="27899416"/>
    <dbReference type="eggNOG" id="ENOG502S1QI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076143_0_0_1"/>
    <dbReference type="OMA" id="LHSPIWT"/>
    <dbReference type="OrthoDB" id="60858at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37919:SF2">
        <property type="entry name" value="EXPERA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37919">
        <property type="entry name" value="PROTEIN CBG05606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF16355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="27497" checksum="D263860F9251B2C0" modified="2013-06-26" version="1">MVTTRSGGESTKSPTKPTTAAPKPPTTTTTTTRTTKPSTSTTSSSPTKPWTHTPRPLTLLWLTLSTPLVLWDAGYVLLRPHSMVGGKYHSPLWTPYALYAEIDYVYGWKALQENNSWTQTQTWFNLGEVLAYAVYLGWVWGGGYAKGKGIFEGRTLEGRRAAWAVLVGFSAASLTFYKTVMYWLLEYLSGFENIGHNDWTTLITMWIIPNGAWLIGPSYMMYVFGGEILQGLEMAATATAPGSTRKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGT1</accession>
    <name>N1QGT1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF866-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_151321</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0587 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757330.1">
        <property type="nucleotide sequence ID" value="XM_016906740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGT1"/>
    <dbReference type="STRING" id="692275.N1QGT1"/>
    <dbReference type="GeneID" id="27903877"/>
    <dbReference type="eggNOG" id="KOG1296">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114688_0_0_1"/>
    <dbReference type="OMA" id="TAHFVWR"/>
    <dbReference type="OrthoDB" id="10248838at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008584">
        <property type="entry name" value="CXXC_Zn-binding_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12857">
        <property type="entry name" value="CXXC MOTIF CONTAINING ZINC BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12857:SF0">
        <property type="entry name" value="CXXC MOTIF CONTAINING ZINC BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05907">
        <property type="entry name" value="CXXC_Zn-b_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141678">
        <property type="entry name" value="MAL13P1.257-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF09209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="160" mass="18270" checksum="20414A8BCF5E44E7" modified="2013-06-26" version="1">MLALTMSAELEGVTDLVPDDTEANPFYYTFKVQCTSCREIHPNWVSFNRFETAEQSGSRGEANFVWKCKNCKREHTANIQDSPQSYSQQSPPKPKNIITLDCRGLEFVEFKADGDWKASGLESGTKFTSIDLTEGEWFEYDEKSSEEVSIKDIKFDIKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGU6</accession>
    <name>N1QGU6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_145691</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764567.1">
        <property type="nucleotide sequence ID" value="XM_016903204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGU6"/>
    <dbReference type="STRING" id="692275.N1QGU6"/>
    <dbReference type="GeneID" id="27900341"/>
    <dbReference type="eggNOG" id="ENOG502SR2C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042941_2_3_1"/>
    <dbReference type="OMA" id="ESWIERD"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF4">
        <property type="entry name" value="CYCLOCHLOROTINE BIOSYNTHESIS PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF16446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="316" mass="37575" checksum="A071327484C31911" modified="2013-06-26" version="1">MEKFSSFLKPHRYVSLTQDSQASDSMEKLLEPQELEARIRHGRSGVLLTWCRAAYLLIAWVLTASLASLWLNALVNPSDLRGIELKDLEFKAAESWIERDIVKFTGTPIFETQDIVYREYNRDYKQYLGNSTEARDNWHELLRDRYFLVTEDEMKAIYPNNYKEYYHTALGWWIGLDGFHILHCVWVVGKALDQARSGKAEDSEYQRYHEDHCLDIIRQSVQCNMDLTPIPERRWHTTEHHFIDSDQKHVCRNIWTLRKFLDVRQNRTKQLIAEYEEREGKPWVEEDSAMGVFGFPEWKGEMKDYRPPYLVEKLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1QH52</accession>
    <name>N1QH52_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Indoleamine 2,3-dioxygenase</fullName>
            <ecNumber evidence="5">1.13.11.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_108626</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Produces N-formyl-kynurenine through the oxidation of tryptophan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-tryptophan + O2 = N-formyl-L-kynurenine</text>
            <dbReference type="Rhea" id="RHEA:24536"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58629"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the indoleamine 2,3-dioxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.52" evidence="5"/>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759900.1">
        <property type="nucleotide sequence ID" value="XM_016900745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QH52"/>
    <dbReference type="STRING" id="692275.N1QH52"/>
    <dbReference type="GeneID" id="27897882"/>
    <dbReference type="eggNOG" id="ENOG502QV6W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010089_0_1_1"/>
    <dbReference type="OMA" id="WHQYSGG"/>
    <dbReference type="OrthoDB" id="540174at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033754">
        <property type="term" value="F:indoleamine 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000898">
        <property type="entry name" value="Indolamine_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657:SF5">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01231">
        <property type="entry name" value="IDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00876">
        <property type="entry name" value="IDO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="proximal binding residue" evidence="4">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600898-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF11779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="427" mass="47663" checksum="250906A3F3E0BF16" modified="2013-06-26" version="1">MSPSRVPLLPSLAALASYNISSNGFLPETTPLSHLPHKYYEPWEILISQISSLIAEQKIRQVVNDSTPILSTEHLASEAEWQRAYSLLAVVAQAYIWAGPEPEERLPPQISIPFLATAEHLQVPPIATYAALNLWNWRPLNECSGRAIDLTEPSNLIALHTATGTDDESWFLIISNAMEARAGPLIHAMLAAMEAVERKDNATIVESLTYFKQSMTDIGKLLERMDDRCHPQVFYHHIRPFLAGSMNMETAGLPNGVFYDEGEGKGSWRKYRGGSNGQSSLLQFFDAVLQINHDRCNGFHDEMRQYMPGPHARFLDDIESIANIRDYVNGLDESRGNSDLIRAYNEAVSSLSEFRNTHIALVTRYIIIPSRQPKPEGCIIRRDIASTSTTLASAEPMTKDLVGTGGTKLIPFLRTSRDETREATVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>N1QH81</accession>
    <name>N1QH81_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Chromatin modification-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_150597</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of an histone acetyltransferase complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The PHD-type zinc finger mediates the binding to H3K4me3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ING family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758634.1">
        <property type="nucleotide sequence ID" value="XM_016906279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QH81"/>
    <dbReference type="STRING" id="692275.N1QH81"/>
    <dbReference type="GeneID" id="27903416"/>
    <dbReference type="eggNOG" id="KOG1973">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006204_0_1_1"/>
    <dbReference type="OMA" id="WAYSNRN"/>
    <dbReference type="OrthoDB" id="5411773at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17016">
        <property type="entry name" value="ING_Pho23p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15505">
        <property type="entry name" value="PHD_ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024610">
        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12998">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01408">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="12">
        <location>
            <begin position="822"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="308"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="859"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="350"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="410"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="437"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="461"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="534"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="584"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="661"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="674"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="697"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="774"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="882"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="825"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="827"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="838"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="843"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="849"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="852"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="867"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="870"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="7">
        <location>
            <position position="824"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="7">
        <location>
            <position position="835"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="7">
        <location>
            <position position="839"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="7">
        <location>
            <position position="847"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF10513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="892" mass="95316" checksum="ACF63184036EF902" modified="2013-06-26" version="1">MAPPMSQLRKSSTATDAHYNNPHHAHPSHNGAPPRTTASGRAIRTNTTRPANYYARPFGSMSAGVDNDANMADQSTQPTGFFPALTFFTDAVTALPKEVMKHFTLMKEVEAKIYNPTDQLGDLIDTLMLQPVPARKQAASTGAPAATAPGLLSLTANNSTTDSAAVSLVNGVGGRHSAQSSMAGSLDGTDVPAGEEELRRRHQYQELRMLAHGMLSNLDEKIVVLNEANRVLSLQNKRIDSVMPHVEGEISEEARLGSTTHWAYSENRQKTKAAAAGANRPRDVAATNNLAAAAAAMHEVDIANARNDAQREAASAGRGKGKGKRAPEPVGDSDFDDTVKPRKAPKVGKGKVAAAAANATGLGISTNGEPAPVKRRKNAEKAPAMERQASTQKNAKGKDTPRSTPANDLTVPKAKVAKTKPAPTKAKKTAVNSAQNSPMLASSPLASSFNPAFIEAPPGPRTQSSRLRQNSIATNLRHERLQDEDSAASRPGSAGGKTNGNGMAEKTNGRKKVQETTEEHDDNTGDEQGLQTRVAREVSQKLKREDADNVDTGSGTERGRPATSRAGSEKGKNGGRGSKVGTPKTDSFPASATVGSAAIARIRSSRRPRTGESGDGDSSSSEAQMPGASTSKHRRNASNSHLVKQLAPFNKSPNLDRHQLDDDDEKGDDEEEDSSAREEKVDENGNVEDEADAEAKRHTRRSTTRRPVSRRNTINSPQLQSSPAPMEESRESSPAASPPPVSTRQSTRSSGRNDHTARSENGYSAAQPHADEPPALEEDVSEDEEETQAEPEEPEEDAAAPEADNENENDDSEHDPDDPNEQKYCYCNRGSYGEMVACDNDNCPKEWFHLGCTGLREAPSPDESWFCRECRPRPGRARGGRGGRGGRGGLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1QHE0</accession>
    <name>N1QHE0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_137362</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764726.1">
        <property type="nucleotide sequence ID" value="XM_016902835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QHE0"/>
    <dbReference type="STRING" id="692275.N1QHE0"/>
    <dbReference type="GeneID" id="27899972"/>
    <dbReference type="eggNOG" id="KOG1269">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046304_0_0_1"/>
    <dbReference type="OMA" id="KMDNMRL"/>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003838">
        <property type="term" value="F:sterol 24-C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050447">
        <property type="entry name" value="Erg6_SMT_methyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068:SF4">
        <property type="entry name" value="S-ADENOSYL-METHIONINE-STEROL-C-METHYLTRANSFERAS (AFU_ORTHOLOGUE AFUA_4G09190)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068">
        <property type="entry name" value="ZGC:194242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="140"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF16605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="383" mass="43309" checksum="3B5B8E4294CAA191" modified="2013-06-26" version="1">MAESAAVAPAPAQHETRPSNVKKPRAPRKSERIQTALRSYKVLKDLTPEQMQNFMDSYQIYSLDWADEKTMIATLGFDYKQKVGQKLADYYCVLNHLCALGELEKMYIPPYLCDKNIITNQWMYEESVCKELTLPPKARVLELGCGRGRVAAHVSQTTSAQITGLNIDQDQLASAREWNKRQGLNNEFIHADFNELPLPLESESYDAFYQIQAFSLAKDHEALCKELYRLLKPGARLSLLDWVSLEAYDPKNEHHQELFRKIKPLIGAVGTPTPASLESALSKAGFRVLQSNNANVGGIQAPLIEQADGYFRMARKAILGGVRVGVFPPHFKTLFNRLTQDCDAFIEADRAGLCTTTWHWLAEKPLTTRAWREVGILDSRDLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1QHE7</accession>
    <name>N1QHE7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_69810</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFB1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758694.1">
        <property type="nucleotide sequence ID" value="XM_016909878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QHE7"/>
    <dbReference type="STRING" id="692275.N1QHE7"/>
    <dbReference type="GeneID" id="27907015"/>
    <dbReference type="eggNOG" id="KOG2074">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019188_1_0_1"/>
    <dbReference type="OMA" id="NRPNFDM"/>
    <dbReference type="OrthoDB" id="360521at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13229">
        <property type="entry name" value="PH_TFIIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005607">
        <property type="entry name" value="BSD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027079">
        <property type="entry name" value="Tfb1/GTF2H1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013876">
        <property type="entry name" value="TFIIH_BTF_p62_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12856">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03909">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08567">
        <property type="entry name" value="PH_TFIIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00751">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50858">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BSD" evidence="8">
        <location>
            <begin position="221"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="453"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="582"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="582"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF10573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="655" mass="72229" checksum="53F285702253D838" modified="2013-06-26" version="1">MPHTSATAAYKKKDGTLTVADDRKYVFWTPAAPTAAPPAVTVPVADITNLQQTPATSKAIALKVVVGDSSYVFTFNHKDNARKEQESTTDVLRNIIAANKAKDANHLATPAAAASAASMAIAKALSSTKVDEGWYDDSKLKSDITLQRSLLESNRTLQERFNEALKQKPETVSIAQFTGQFWSARLHLLRAHAIEKAQKQGEYNVLPEIKFVIKRAEKEGEADTRQLQISKEQIHLIFKQYPIVKEAYNDHVPPLSQAEFWTRFFGSRLLKKLKGEKIMQNDTRDNKLDAYLDRQPSGPASIQHIPHWMDLEGNEQNHSQRKGNRPDQDMRPTSTEKVPILRVLNNLSEKMMAHVAPGDGEAHAPVGLDEETFEQLRLRDLANEDVDNRVKLSIKEQQRYLGGDKDTLSADASLYAKQDPNKVLAVVNAGLQPTQVGSDVKGTLRLDRVIGYHTDDDSDSDDEAPASQTNGTAAKKKHKIGSHASMIAASKTIVSSIKTRRDFSSTDATSLNGLSQDTFDNLIMTHNTTNEFLHYFWTLFLSGDATKTAELAQLVSTLDRSLDRINAVGAQADAERAQKVENLRRQAEQHHQRTGKKRRIDYDSAVPGGKRAVDAMVKPTVQALAQATSAYRKAFQEQSKEASAAAATVASGGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1QHJ5</accession>
    <name>N1QHJ5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lytic polysaccharide monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_142137</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760050.1">
        <property type="nucleotide sequence ID" value="XM_016902986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QHJ5"/>
    <dbReference type="STRING" id="692275.N1QHJ5"/>
    <dbReference type="GeneID" id="27900123"/>
    <dbReference type="eggNOG" id="ENOG502S005">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032571_1_0_1"/>
    <dbReference type="OMA" id="TWFNHVG"/>
    <dbReference type="OrthoDB" id="2342176at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182:SF2">
        <property type="entry name" value="LYTIC POLYSACCHARIDE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110336" description="Lytic polysaccharide monooxygenase" evidence="2">
        <location>
            <begin position="23"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="334"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF11929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="440" mass="44332" checksum="1E0610B547CC54A2" modified="2013-06-26" version="1">MFAKSFLTAAAACSLLVSSVNAHMVITSPVPYGADSLTNSPLEPDGSDFPCKQRSGVYDIGTMNQIPVGVPQKLSFKGGATHGGGSCQLSVTLDKEPTKNSQWKVIHSILGGCPNSDAGNANGSPDYAGNPTFEYTMPKGMPNGEYTMAWTWFNKIGNREMYMNCAPITVTGGADNNDVLDTLPDMFVANIGNGCTTCENEDFVFPQCGRNVETVMKTALGSSTIGTCAVATGGAGSGSSGAAPSAPVAYSTPASSPAAPTGYGSGSGASAPAQGSAPDTAPTAPSYGTSSAAAQAPAPTGYGGASSAEGGPAGGGVATAYEVVTQTAMRTITADGPAPSGYASPAASGPPETSDESGSSNKAATGNKTSSSSKSIACTTQDEIICMDGGKFGICDNGFAVPMQLSDGMSCSAGVISKRSNMGRHLRRFSSRCINQRLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1QHK5</accession>
    <name>N1QHK5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RRM_1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_165288</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758759.1">
        <property type="nucleotide sequence ID" value="XM_016908164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QHK5"/>
    <dbReference type="STRING" id="692275.N1QHK5"/>
    <dbReference type="GeneID" id="27905301"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050545_0_0_1"/>
    <dbReference type="OMA" id="RESRTVH"/>
    <dbReference type="OrthoDB" id="272703at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21245">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="6"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="133"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="237"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="79"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="199"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="340"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="346"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="360"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF10638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="390" mass="44074" checksum="A62D65009F1BA174" modified="2013-06-26" version="1">MSYESPRLYVGNLPYVAQREDIEKLFAENHVDINKVDISIDPETGRNPSYCFVEFKTQEDATNAMNSLQGINLQGRALRINPKTDRKPNPTAERTARGWGPRATDGNENSYPNNRWKREDAQPQWNAPAEDPKRVYVGSLHASDQETINAEMKSLFEGYEVTSVSKLITPQSALPDQNSSFCFVEVATPAQAVEAVRNLNGRPTPHGDIYRVSHAKGKRGPTTGEREPWKSQQVETSKVFISGLPQIATQEELDHQIRELFAGLQINEISKLITPHESKQTESGNHHYCFATFDRQEEAQRGVEAMNGQPTPNGGIYKISFARERPAGNFGQADRFQQREGGYQSRGGFQQRDGFQQREGGQDSPRRQQREQPQGPPVNRDFGSSWRRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1QHM7</accession>
    <name>N1QHM7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DHS-like NAD/FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_56413</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764867.1">
        <property type="nucleotide sequence ID" value="XM_016909400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QHM7"/>
    <dbReference type="STRING" id="692275.N1QHM7"/>
    <dbReference type="GeneID" id="27906537"/>
    <dbReference type="eggNOG" id="KOG2684">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023643_3_1_1"/>
    <dbReference type="OMA" id="LIHMHGE"/>
    <dbReference type="OrthoDB" id="424302at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036054">
        <property type="term" value="F:protein-malonyllysine demalonylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036055">
        <property type="term" value="F:protein-succinyllysine desuccinylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01412">
        <property type="entry name" value="SIRT5_Af1_CobB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027546">
        <property type="entry name" value="Sirtuin_class_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF10">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="5">
        <location>
            <begin position="4"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF16746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="297" mass="32204" checksum="6BE2C2E56019F102" modified="2013-06-26" version="1">MAAPFAGPEAVTSFHECLKKSSRVMCLVGAGLSSASGLPTFRGAGGLWRTHDAVSLASPAAFAKDPALVWRFYSYRRHMALQALPNAAHYALAELARRMPGFITLSQNVDGLSQRAGHPRDNLQLLHGTLFEVKCTDPGCGYAAENFVDPITPALDIPTPRNPESAMQDISDATVPLPDIPPEGLPHCPRCTESLLRPNVVWFGEQLPVAVLDRLDEYLNESDHIDLIMVIGTGAKVYPAAGYIDHARYRSAKVCVVNMDPNDVPPGGWKKGDWFFQGDAAQLVPELLRPIIGNLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJD2</accession>
    <name>N1QJD2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Cytochrome b5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SEPMUDRAFT_77504</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Microsome membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12 13">Belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765467.1">
        <property type="nucleotide sequence ID" value="XM_016910164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJD2"/>
    <dbReference type="STRING" id="692275.N1QJD2"/>
    <dbReference type="GeneID" id="27907301"/>
    <dbReference type="eggNOG" id="KOG0537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102602_3_2_1"/>
    <dbReference type="OMA" id="KEFTMQD"/>
    <dbReference type="OrthoDB" id="260519at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000002">
        <property type="entry name" value="Cytochrome b5 type B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359:SF150">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0492">Microsome</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="15">
        <location>
            <begin position="4"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMF17346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="137" mass="14597" checksum="EE86CB0AA9411718" modified="2013-06-26" version="1">MAESKEFTYSDVSEHTSKKDLYMVIHDKVYNTSSFVDEHPGGEEVLLDVGGQDATEAFEDVGHSDEAREILDGLLIGTLKRQAGDPQPKTAAQQVADARKSSTASGGLGAGVYAVVLVGAALAFFAYQQLQSSQNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJH5</accession>
    <name>N1QJH5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial import receptor subunit TOM7 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Translocase of outer membrane 7 kDa subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_46917</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760086.1">
        <property type="nucleotide sequence ID" value="XM_016909020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJH5"/>
    <dbReference type="STRING" id="692275.N1QJH5"/>
    <dbReference type="GeneID" id="27906157"/>
    <dbReference type="eggNOG" id="KOG4449">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_173610_1_0_1"/>
    <dbReference type="OMA" id="FILYLGW"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005742">
        <property type="term" value="C:mitochondrial outer membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903955">
        <property type="term" value="P:positive regulation of protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012621">
        <property type="entry name" value="Tom7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46722">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46722:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08038">
        <property type="entry name" value="Tom7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF11965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="62" mass="6991" checksum="950E18651D4E5B26" modified="2013-06-26" version="1">MAWLALSEESKERIARVIDLSRVAIHYGYLPLIIYLGYTRSNPRPSLIRYVELGVEDGGVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJK3</accession>
    <name>N1QJK3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoinositide phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_146425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765506.1">
        <property type="nucleotide sequence ID" value="XM_016903646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJK3"/>
    <dbReference type="STRING" id="692275.N1QJK3"/>
    <dbReference type="GeneID" id="27900783"/>
    <dbReference type="eggNOG" id="KOG1889">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003016_7_4_1"/>
    <dbReference type="OMA" id="ITKAQPV"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072517">
        <property type="term" value="C:host cell viral assembly compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017059">
        <property type="term" value="C:serine palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052629">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043812">
        <property type="term" value="F:phosphatidylinositol-4-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061909">
        <property type="term" value="P:autophagosome-lysosome fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662:SF2">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3-PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="585"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="618"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="SAC" evidence="2">
        <location>
            <begin position="117"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF17385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="696" mass="78579" checksum="7118ABBEFDB18255" modified="2013-06-26" version="1">MSATLPFRDINVHASSTYYAFSSPSSPNAPTLVVDRPSGDIRLHDGKVTGGHRVSSISGILGIIKLRLDSYIIVITKSQAEGRLKGHQIYKVISTEFLPLRERQVHDPDEDTYLAYLKALLKNGPMYFSYSFDLTNSFQRQARLDANEPLWQRADDRFFWNRFISTSLINLRQGKTASRVSPGPQPAADPYILPVMYGMMRITNTSIKGNPLTFVLVTRRSRFRTGTRYLSRGIDEDGHVSNYNETEQAVILNDTLSGGMTSYAGDRGVTSGAPGSGSETQVLSYVQTRGSVPVYWAEINSLKYTPKLQIRGVETAVNAAKKHFDEQIQLYGENYMVNLVNQKGREMRVKDAYEQLVKILQSNPTEHTEADHRTRVKFDVIEPDDQRSWYDHLHYVYFDFHNETKGLKWHRAQLLLDQLADGLTAGGYFHGIDRPSGGVDVRRKQTAVVRTNCMDCLDRTNVVQSMLGRWTLTRMLIDLGVLRPGETAQDDQTFEDIFRNVWADNADVVSKTYSGTGALKTDFTRTGNRTRAGMLQDLRNSCTRYVRNNFADGPRQDAFDLFLGHYSPDTTGIGSLQQFADRRPLVIQAVPYVLGFCVFFVAVSVSTNRLPNSTVWPLRLFTLFSLAVAGYSGRFMWNHGTLYVNWPKLNTPQWAVEAYQDTLEKVTKDPLLGAFIAGGNRDARLGTLEEGKKRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJW9</accession>
    <name>N1QJW9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidase signature enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_58039</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765652.1">
        <property type="nucleotide sequence ID" value="XM_016909458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJW9"/>
    <dbReference type="STRING" id="692275.N1QJW9"/>
    <dbReference type="GeneID" id="27906595"/>
    <dbReference type="eggNOG" id="KOG1211">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_14_2_1"/>
    <dbReference type="OMA" id="CGGDTMN"/>
    <dbReference type="OrthoDB" id="566138at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678:SF5">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110927" evidence="1">
        <location>
            <begin position="19"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="36"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF17531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="551" mass="58455" checksum="7362CDF07DB9E9FB" modified="2013-06-26" version="1">MLVLALPLVLATFDAREATISSTHHALFTGLATCREVVSSFLSRIEAFNNETNAIISLNPRALEIADEYDGEIQRNHGSYGSLFCVPTLLKDNYDTADMRTTGGSVALRESQPTLDAPAVKVLKDSGAIIIGKANLHELALEGLSVSSLGGQTMNPYDRTRTPGGSSGGTGAAIAASFAVWGTGTDTVNSLRSPASANGLFSCRPTRGLISRSGVIPISYTQDVLGPIGRCVKDIAVALTVMAGTPYDPSDNATALVPSGIRGSDFSQGLTQGSLEGLRFGLLEGFFNRTVSDETDPVNQAMANMTAKLQAAGATIIPITDEMYNATAIASLDTQRYEFRESLDAYLQRPSLSGSHPTTTNELYTSDGYLVIPAQYEYVNTALLSSTANTTTTTTTTSTTKPSYATIMSRIHNLTLALHATLVENRLDALLYPEQKNLVVKIGSPSQSGRNGILAALTGTPVVTVPVGFSAATEDAPEGVPIGMEILGSAWTEGKLLQIASHIERLGRVRRSPRWALESVEVKEYLQDVPVIVPDAGNVNLQAYPLGTLHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1QK85</accession>
    <name>N1QK85_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PhoD-like phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_76065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764778.1">
        <property type="nucleotide sequence ID" value="XM_016910122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QK85"/>
    <dbReference type="STRING" id="692275.N1QK85"/>
    <dbReference type="GeneID" id="27907259"/>
    <dbReference type="eggNOG" id="ENOG502QPI0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000998_3_0_1"/>
    <dbReference type="OMA" id="GPNLWND"/>
    <dbReference type="OrthoDB" id="9999821at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043904">
        <property type="entry name" value="PhoD_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689:SF3">
        <property type="entry name" value="PHOD-LIKE PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19050">
        <property type="entry name" value="PhoD_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoD-like phosphatase" evidence="2">
        <location>
            <begin position="192"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD-like phosphatase" evidence="2">
        <location>
            <begin position="421"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD-like phosphatase" evidence="2">
        <location>
            <begin position="503"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="666"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="707"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="671"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF16657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="769" mass="85321" checksum="71DE92FB47BEA265" modified="2013-06-26" version="1">MAPAMGDVHQSDVEGGRSREAPDALNNDTGLPGATPAVQPEATQQEVPRHENGIGNGPQVRGTNNGLEIVCGPLLNYKHMSNEFSDHPQWHGSVLIVTPPGQQPGQLSLHCTGAWTGAAATTNGNGHVNGYGNGTSASQERTFPAERLYEDPKKAFWRYVIDVPFQEQESTWQYSIPNMISTKDKTPIQKPLRFVVPSRHESMRIMFHSCNGFSVGTDMKTWTGPVLWKDVLRVHNEQPLHIMIGGGDQIYNDSVRVDGPLRPWTDISSPRKRREFPFNEEMRKKCDDFYYDNYVRWYGTDEFALANGQIAQLNIWDDHDIIDGYGSYVHHFMKCSVFRGIGGVAHKYYLLFQHHIPPPPSTYSTDAPQTTQTTGETTAPDAVQLQDTYVMTPKTEDPSWIIGTRPGPYLEERSRSIYCQLGKRVAFLGLDARTERTRHQINYPETYDQIFKRTSEELQRSNGSIKHLVLLLGVPIAYPRLQWLENIISSPIIGPIKFLNKRFGVAGALFNQFDGGVDLLDDLDDHYTAHQHKKERKALIHRLQEISKQHSVRITILGGDVHLAALGRFYSKASLNIPAERDFRYMPNIVSSAITNKPPPAAVANLLARRNKIHHLDHETDETLLEMFDKDPGFGEEGVDSKTANKNHATMPSRNYAIISESHSHTGDVQTNGAATNGTTNGAGDASIDTNFSLPKNMREPIHPGEVQAGTQHPAAGGIKKTGLGGRDGLDVSIRVEIKPGASDGRTEGYGISIPALESGAYQGQGTSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKZ6</accession>
    <name>N1QKZ6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_34955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764419.1">
        <property type="nucleotide sequence ID" value="XM_016908586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QKZ6"/>
    <dbReference type="STRING" id="692275.N1QKZ6"/>
    <dbReference type="GeneID" id="27905723"/>
    <dbReference type="HOGENOM" id="CLU_2475120_0_0_1"/>
    <dbReference type="OrthoDB" id="5392716at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF16298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="88" mass="10531" checksum="B4A8648DABBB7932" modified="2013-06-26" version="1" fragment="single">VGLIRIARLRKEIGLYKRILVAYREEAELGIVEVLRKELEDGGIKDLSRRMLYEYIRSKYNIVSRDRLYRVLDTLNPEAVRRRRVKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1QL16</accession>
    <name>N1QL16_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="7">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_87137</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="7"/>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759977.1">
        <property type="nucleotide sequence ID" value="XM_016910434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QL16"/>
    <dbReference type="STRING" id="692275.N1QL16"/>
    <dbReference type="GeneID" id="27907571"/>
    <dbReference type="eggNOG" id="KOG0787">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023861_0_0_1"/>
    <dbReference type="OMA" id="ICEAQEH"/>
    <dbReference type="OrthoDB" id="407390at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF25">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase N-terminal" evidence="10">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="9">
        <location>
            <begin position="177"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="267"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF11856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="352" mass="39606" checksum="5336AD772624ADC0" modified="2013-06-26" version="1">MQTLPYSAVRNPHISHVYELYYDAFEKFRKVPPVRSLDDNDRFCEVIKSLLKDHLSVIPQLAMGILEIQHSVSSEECDRFMTTLLRSRISRRVIAEQHLALTETYHSPWHFPNAKKPLTAPEDEFVGEIFLKCNAKEVVQKCAATARDLVREAYGPDVAIPEVVLQGHLDTTFAYIPSHLEYIVGELLRNSIQAVVEQKGLKNSPPIEVLICEAAQHIIIRVSDQGGGVDREVLPYLWSFAKGPRRSNRLKNLGRVPRLAATTQELKTPEDHDRAGKKPGEQFKDSLASLLNRPPDLKLGMGLPMSKIYAEYWAGSLEVHSLEGWGCDAFLQISRLGNKNETLSSRAAMDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>N1QL58</accession>
    <name>N1QL58_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_146877</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016766117.1">
        <property type="nucleotide sequence ID" value="XM_016903930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QL58"/>
    <dbReference type="STRING" id="692275.N1QL58"/>
    <dbReference type="GeneID" id="27901067"/>
    <dbReference type="eggNOG" id="KOG0181">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_4_1_1"/>
    <dbReference type="OMA" id="ATCIGKD"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03750">
        <property type="entry name" value="proteasome_alpha_type_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1 2 3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="5">
        <location>
            <begin position="5"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF17996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="281" mass="30287" checksum="D312AFDDE16E1C93" modified="2013-06-26" version="1">MADRYSFSLTTFSPSGKLVQIEYALNAVNQGVTSLGIKAANGVVLATEKKSSTPLIDASSSSKVSLITPNIGMVYSGMGPDYRVLVDKARKVSHTGYKRIYNEYPPTRILVQDVARVMQEATQSGGVRPYGVSLLIAGWDDGILPEQEEAEAAEEMDVDDKKKKSGKTGGILKGGPSLYQVDPSGSYFPWKATAIGKSATSAKTFLEKRYTEGLELEDAVHIALLTLKETIEGEMNGDTVEIGIIGDPADHLLGYEGVEGATGPRFRTLSPQEIEDYLTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1QLG3</accession>
    <name>N1QLG3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MADS-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_145721</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764604.1">
        <property type="nucleotide sequence ID" value="XM_016903226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QLG3"/>
    <dbReference type="STRING" id="692275.N1QLG3"/>
    <dbReference type="GeneID" id="27900363"/>
    <dbReference type="HOGENOM" id="CLU_1908000_0_0_1"/>
    <dbReference type="OrthoDB" id="2284405at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="7">
        <location>
            <begin position="38"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF16483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="133" mass="14840" checksum="8848792E2C2DD8A6" modified="2013-06-26" version="1">MQQASQKENGASETRGIKQQRTSAAADDDDYDNNKPGRERRKIEIKFIQDKLRRYITSSKHKAGIMKKVQASTTRLKTAMHWGDATSVSAACWGGNTVSSSGKYFTYFDKAAEESTSSHAFQVVACDSFPRLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1QM43</accession>
    <name>N1QM43_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_146384</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>oxaloacetate + acetyl-CoA + H2O = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>propanoyl-CoA + oxaloacetate + H2O = (2S,3S)-2-methylcitrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23780"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:58853"/>
            <dbReference type="EC" id="2.3.3.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Organic acid metabolism; propanoate degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the citrate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765453.1">
        <property type="nucleotide sequence ID" value="XM_016903619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QM43"/>
    <dbReference type="STRING" id="692275.N1QM43"/>
    <dbReference type="GeneID" id="27900756"/>
    <dbReference type="eggNOG" id="KOG2617">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022049_2_1_1"/>
    <dbReference type="OMA" id="IDHGFNA"/>
    <dbReference type="OrthoDB" id="8017587at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050440">
        <property type="term" value="F:2-methylcitrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006101">
        <property type="term" value="P:citrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019629">
        <property type="term" value="P:propionate catabolic process, 2-methylcitrate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.230.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.580.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010109">
        <property type="entry name" value="Citrate_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01793">
        <property type="entry name" value="cit_synth_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007128">
        <property type="entry name" value="PRK09569.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739:SF15">
        <property type="entry name" value="CITRATE SYNTHASE 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="active site" evidence="9">
        <location>
            <position position="309"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR610109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF17332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="473" mass="51816" checksum="331474EC5D01BA51" modified="2013-06-26" version="1">MALSSRTAARALRASKLVHSAPVVCNASRSYATAEPDLKETLRNAIPEKRELLKKVKAHASKTIGEVKIENTIGGMRGLKAMVWEGSVLDANEGIRFHGKTIKDCQQELPKGTSGTEMLPEAMFWLLLTGQVPSTNQVRAFSKELAEKAQLPAFVNEMLDNFPKDLHPMTQFACAVSAMQYESVFAKAYERGISKADYWEPTFDDSINLLAKLPTIAAKIHQNAYCGGGALPAEVDLNQDWSYNFAAMLGKGGSENENFQDLLRLYLALHGDHEGGNVSAHATHLVGSALSDPYLAYSAGLQGLAGPLHGLAAQEVLRWILQMKDHIGTSFSDQDVKDYLWSTLKSGRVVPGYGHAVLRKPDPRFEALMDFASSRKEIAEDPVFQLVKKNSEIAPGILTEHGKTKNPFPNVDSSSGVLFHHYGFHNTLYYTATFGVSRGLGPLAQLIWDRALGLPIERPKSIDLKGLLKLAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1QMX2</accession>
    <name>N1QMX2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein S30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_76587</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS30 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765030.1">
        <property type="nucleotide sequence ID" value="XM_016910147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QMX2"/>
    <dbReference type="STRING" id="692275.N1QMX2"/>
    <dbReference type="GeneID" id="27907284"/>
    <dbReference type="eggNOG" id="KOG0009">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010412_5_2_1"/>
    <dbReference type="OMA" id="YCVAERE"/>
    <dbReference type="OrthoDB" id="199599at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006846">
        <property type="entry name" value="Ribosomal_eS30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12650">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S30/UBIQUITIN-LIKE PROTEIN FUBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12650:SF15">
        <property type="entry name" value="RIBOSOMAL PROTEIN S30, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04758">
        <property type="entry name" value="Ribosomal_S30"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="37"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF16909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="95" mass="10707" checksum="6A7E77FFA4A58314" modified="2013-06-26" version="1">MGKVHGSLARAGKVKSQTPKVRVPQMLLCCYCVAEREHGENKNSRRPSGEEADVEPQEKKKVPKGRAKKRIQYTRRFVNVTMTGGKRKMNPNPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1QN03</accession>
    <name>N1QN03_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_160996</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765933.1">
        <property type="nucleotide sequence ID" value="XM_016907917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QN03"/>
    <dbReference type="STRING" id="692275.N1QN03"/>
    <dbReference type="GeneID" id="27905054"/>
    <dbReference type="eggNOG" id="ENOG502S6BM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021768_3_3_1"/>
    <dbReference type="OrthoDB" id="2906425at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF17812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="161" mass="18592" checksum="81712FDB8867945C" modified="2013-06-26" version="1">MIKWNCEEPELEGLRYVAANTDILIPRLCRVHRSHHQLALEMGFFSGCGPLQVCWRNYTCNQKQAIVDEIVAFIKQLRKLEAPCPQRISRTARFGPFDDIAAFHDCVRDGIALEYVQGSFGAKVLQVHQRQILVRDAKVVALIDWECAGWYPGYWEYTRAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1QN24</accession>
    <name>N1QN24_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_146772</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765963.1">
        <property type="nucleotide sequence ID" value="XM_016903856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QN24"/>
    <dbReference type="STRING" id="692275.N1QN24"/>
    <dbReference type="GeneID" id="27900993"/>
    <dbReference type="eggNOG" id="KOG3855">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_9_2_1"/>
    <dbReference type="OMA" id="DYWKVFV"/>
    <dbReference type="OrthoDB" id="1716816at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02979">
        <property type="entry name" value="PHOX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF20">
        <property type="entry name" value="2-MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G13660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="5"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="7">
        <location>
            <begin position="454"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="468"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="702"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="702"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="717"/>
            <end position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF17842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="736" mass="81482" checksum="0BABE5BA5C31AA44" modified="2013-06-26" version="1">MATSKVDVLIVGAGPAGLMAANWLSRLNVKTRIIDKRGTKIFNGQADGLQCRTLEIFDSFGFADRAWKESNHMLEINLWNPDENGKLFRSDKIPDTIPNISRFQQVVLHQGRIERFFLDSISAHSDIVVERGVLPETLEFDESQAEDDDAFPITVKLRHLSEEEATPKQNATSANGAGMQDGLFRSNLAPDDTEELIKVSKLADKAGSTETIQARYMVGCDGAHSWVRNQLGFKLRGESTDYIWGVLDVIPITDFPDIRMRCAIHSASSGSLMVIPRENKLVRLYIQLTTTNDLGGGKVDRSKINPEVILSAAQRILHPYKLTYKYCDWWTAYQIGQRVGDNFSLKERIFLAGDAVHTHSPKAGQGMNVSMQDTYNLGWKLGAVINGLSSRSILKTYQSERRRIAQDLIDFDHKFSRLFSGRPAKDLMDEEGINLAEFKEAFVKGNMFASGLSVNYGKSLLVAKEGNAAEQGDGTEVSSSSPHQDEAQSKPSLATNITIGMRIPSFKVLNQSDARPWHLHELLPSNGRWRILIFPGDILSSPTSHKRLLSLSEKLSSPTSFIRKFTPSPSSLPHSSSTSHSPLTSLIEPLLIHSTPRKSTTIFTFPPIFRPFSPTHGYDYTKIYVDDESYHEGHGHLYQNLGIDPSRGCAVVVRPDQYVAWVGEMDSDGYEAMEKFFGGFMKVQEEGRGCVGVGIEEEDFKEEGVQLEKQKQKQDDGGGGGGVGGLDGSVEGVGAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1QN53</accession>
    <name>N1QN53_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Acyl-protein thioesterase 1</fullName>
            <ecNumber evidence="3">3.1.2.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Palmitoyl-protein hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SEPMUDRAFT_146807</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Hydrolyzes fatty acids from S-acylated cysteine residues in proteins with a strong preference for palmitoylated G-alpha proteins over other acyl substrates. Mediates the deacylation of G-alpha proteins such as GPA1 in vivo, but has weak or no activity toward palmitoylated Ras proteins. Has weak lysophospholipase activity in vitro; however such activity may not exist in vivo.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="3.1.2.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="3"/>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016766018.1">
        <property type="nucleotide sequence ID" value="XM_016903878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QN53"/>
    <dbReference type="STRING" id="692275.N1QN53"/>
    <dbReference type="GeneID" id="27901015"/>
    <dbReference type="eggNOG" id="KOG2112">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049413_3_8_1"/>
    <dbReference type="OMA" id="WYDILAM"/>
    <dbReference type="OrthoDB" id="2418081at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000010">
        <property type="entry name" value="Acyl-protein thioesterase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF17">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="13">
        <location>
            <begin position="8"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMF17897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="243" mass="25826" checksum="32A0BC54997EDF66" modified="2013-06-26" version="1">MATAGAAAIVVPAVKRHTSTVIVAHGLGDSGAGWAFLAGEYRRESLFPETKFIFPNAPSIPITVNGGMKMPGWFDIANFGDIANRSQDEEGLLRSRKVFHNMIEEEIKAGVPSDRIVLGGFSQGGAMALLAGISNPTKLGGIFGLSCYLPLHQKTTELVPTDAPNKETPIFMGHGDADPVVKYSWGQFSAEHLKGLGYSVDLKTYKGLPHSASPQELLDLKAYLQSRIPEMGDKAASGASGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNG1</accession>
    <name>N1QNG1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_146331</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765375.1">
        <property type="nucleotide sequence ID" value="XM_016903581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNG1"/>
    <dbReference type="GeneID" id="27900718"/>
    <dbReference type="eggNOG" id="KOG0754">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_5_2_1"/>
    <dbReference type="OMA" id="LPFQYQF"/>
    <dbReference type="OrthoDB" id="434783at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005310">
        <property type="term" value="F:dicarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006839">
        <property type="term" value="P:mitochondrial transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000034">
        <property type="entry name" value="Mitochondrial 2-oxodicarboxylate carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051752">
        <property type="entry name" value="Mito_2-oxodicarb_carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46356">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46356:SF1">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="7"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="108"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="205"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF17254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="300" mass="32804" checksum="3453F296953B8C34" modified="2013-06-26" version="1">MSTDKPLPFIYQFAAGAVAGVSEILVMYPLDVVKTRVQIQGRVPVPGQDFYTGMGDCFKKIVANEGFSRLYRGISAPILMEAPKRATKFAANDEWGKFYRNLFGVAKMNQSLSILTGASAGATEAFVVVPFELVKIRLQDRAQAAKYNGMIDCVTKIIRNEGPLTLYQGLESTMWRHILWNSGYFGCIFQVRALLPANPSGDKSIQMRNDLLSGSIGGTVGTILNTPMDVVKSRIQNSTKVVGGVPKYNWAWPALGTVAKEEGFAALYKGFLPKVLRLGPGGGILLVVFTGVMDFFRTLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNU8</accession>
    <name>N1QNU8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_153536</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765765.1">
        <property type="nucleotide sequence ID" value="XM_016907513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNU8"/>
    <dbReference type="STRING" id="692275.N1QNU8"/>
    <dbReference type="GeneID" id="27904650"/>
    <dbReference type="eggNOG" id="ENOG502SB54">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065618_3_0_1"/>
    <dbReference type="OMA" id="NQTMSSA"/>
    <dbReference type="OrthoDB" id="5589325at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052982">
        <property type="entry name" value="SRP1/TIP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633:SF1">
        <property type="entry name" value="GPI ANCHORED SERINE-THREONINE RICH PROTEIN (AFU_ORTHOLOGUE AFUA_1G03630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633">
        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004111054" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="4">
        <location>
            <begin position="18"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="5">
        <location>
            <begin position="32"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="113"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF17644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="244" mass="23983" checksum="231813022D52001F" modified="2013-06-26" version="1">MFVKSILVGALAALAAAQSSVISFTNSLPSPAEAGKPFTLTYTTTGSGPVSIILRKGNPNDLQTVATLTSDATGGSYQWTPATDLASGTDYALQIQQGSEINYLGPFPLTGGSASGGGSSSSSSMSTPMAPPSYGPMTTMTSSTEMTSMMMTSTAASNSTSSFTTTAMMPVGTGNATMTRNATMSMATLTKSAGPHATNGGGAGYQGTSTGPNAAQSTGGASTLMVGGSAIAIVFGAVAAVVMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1QP07</accession>
    <name>N1QP07_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyltransferase family 31 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_146841</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016766060.1">
        <property type="nucleotide sequence ID" value="XM_016903902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QP07"/>
    <dbReference type="STRING" id="692275.N1QP07"/>
    <dbReference type="GeneID" id="27901039"/>
    <dbReference type="eggNOG" id="KOG2246">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024640_0_0_1"/>
    <dbReference type="OMA" id="RDASTQW"/>
    <dbReference type="OrthoDB" id="414175at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006740">
        <property type="entry name" value="DUF604"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10811">
        <property type="entry name" value="FRINGE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04646">
        <property type="entry name" value="DUF604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF17939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="347" mass="40081" checksum="6000F9416BAD02DF" modified="2013-06-26" version="1">MKRIEDSLPTFSRWLSNTGSPLVVLLVDQTDLKNVEEDILRTQAQAEALAIELIFEPYHHTFEHDSEGLKNFGLATVLDKNRREETRWFGIIDDDTFFLSLQRMLENLAPYSPESPWYIGALTEGHTRVAKEGFKAWGGAGFFISPPLMRTLAEHAIECTRLDQFFGDLLWRDCIQDVTSPTVHLTEMRGLNQIDMWHDISGWYEAGFNPILTVHHWKSWHFYPVAVGHIVADVAGPDSFLQRYQFGNQTVFTNGFSIAEYPHGMPDLNLVELTMTEDVNVVRAPPQLEFHHSMGHTRPALELGQDKIQWRFEYAVQTSDGIVRQFYTKRMNDDRDVSIIEIDWRHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M3AR67</accession>
    <name>M3AR67_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_9158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF07954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756075.1">
        <property type="nucleotide sequence ID" value="XM_016910560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AR67"/>
    <dbReference type="GeneID" id="27907697"/>
    <dbReference type="eggNOG" id="ENOG502SXX0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060131_6_4_1"/>
    <dbReference type="OMA" id="WYLELIS"/>
    <dbReference type="OrthoDB" id="2115692at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="138"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF07954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="197" mass="22064" checksum="8D050AE39129BB35" modified="2013-05-01" version="1" fragment="single">PKPPIQIRPAIPSDLPSLTTIVPRAFHPRNAYIKKCHPDTPAVRAWWWKIFAEEIAEPDCYVLVAAIENRKEQQNQNQKDSPLLPCGFWTKYPLTPDQNSTLFQPAITAMSQARALAFSPSPSKPTPNQAAPQPHFLLELLGISHDYQNLQLARRLLTLAGEISDKAGWETFVEANANAVGLYRKMGFEEVGKVEIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M3AR96</accession>
    <name>M3AR96_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Glycoside hydrolase family 31 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SEPMUDRAFT_152306</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Glucosidase involved in the degradation of cellulosic biomass. Has both alpha- and beta-glucosidase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF07989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756110.1">
        <property type="nucleotide sequence ID" value="XM_016907365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AR96"/>
    <dbReference type="STRING" id="692275.M3AR96"/>
    <dbReference type="GeneID" id="27904502"/>
    <dbReference type="eggNOG" id="KOG1065">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000631_11_0_1"/>
    <dbReference type="OMA" id="YKGAVWP"/>
    <dbReference type="OrthoDB" id="5839090at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06602">
        <property type="entry name" value="GH31_MGAM_SI_GAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002044">
        <property type="entry name" value="CBM20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF67">
        <property type="entry name" value="ALPHA_BETA-GLUCOSIDASE AGDC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00686">
        <property type="entry name" value="CBM_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01065">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51166">
        <property type="entry name" value="CBM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 14 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004031743" evidence="15">
        <location>
            <begin position="21"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="domain" description="CBM20" evidence="16">
        <location>
            <begin position="478"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMF07989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1002" mass="110611" checksum="647D500E72513E95" modified="2013-05-01" version="1">MAPPSLFLGALALAASAVTASPFALRRRQNGTDSTCPGYRASGITTTANGLTAQLTLAGTPCNIYGNDIEDLTLTVEYQTDTRLHVLIEDAAQQVYQVPGSVFPRPISSGTQNASSELMFEYVEEPFSFTVKRRSSGDVLFDSSAASLIFEDQYVRLRTALPENPNLYGTGEHTDPFRLMTTDYTRTAWNRDAYGTPAGTNLYGTHPIYYDHRGANGTHGVFLLNSNGMDFKIDTTDGQHLEYNTLGGVLDFYFLAGPSPVEVAQQYSEVSQKSALQPYWGLGFHQCKYGYRDVYWVAEVVANYSAAGIPLETMWTDIDYMYLRRVFTLDPDRFPLNLMSELVSTLHERQQHYIVMVDPAVAYQDYDGFNNGVEQDIWLQTSNGSIFKGVVWPGVTAFPDWFHPNTQGYWNSEFQSFFDPETGVDIDALWIDMNEPSNFCDYPCADPEYEAQAAGNPPQPPAIRLGAPRAIPGFGSDFQPLCKSVVTFNVNASTFFGENIYVFGSAITIGSGDEIGNAAPLNANNYPIWSAAVDLPANTQVTYQYVRSAGSGVYSYESSNRTLTTGDCNSTSSVDDIITTSSSPQTKLVRRSDDFSRKAHHLTPVSKRQFAGDKTGLPDRDLINPKYQIANAAGSISNLTASTDIIQYGGYSQYDTHNVYGAQMSEASRIAMLSRKPTLRPLIITRSTFAGAGSQVGKWLGDNLSNWDSYLFAIKEILEFAALYNVPMVGTDVCGFGGNTNELLCARWAQLGAFSPFYRNHAQNDAIDQEFYRWPIVTEAAKIAIEIRYKLLDYIYTASYVQNQTGTPLIQPMFFHYPEDSNTFDLGYQYFYGPGLLVAPVTTENSTTATHYLPDDVFYDYYTHETVIGTGSTITIEDVPYTSIPLYYKGGAILAQRSESANTTTELRKQDFDIIVAPSANGTAYGELYIDDGVSLVQTASSYMKFTYYSDGRFTITGEFGYDTDVFIKTVTVLGTGASNSTGVSRTKSLGISLNQAYEGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M3AVN6</accession>
    <name>M3AVN6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">26S proteasome subunit P45</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_151159</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758252.1">
        <property type="nucleotide sequence ID" value="XM_016906638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AVN6"/>
    <dbReference type="STRING" id="692275.M3AVN6"/>
    <dbReference type="GeneID" id="27903775"/>
    <dbReference type="eggNOG" id="KOG0651">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_2_2_1"/>
    <dbReference type="OMA" id="DHEPCVI"/>
    <dbReference type="OrthoDB" id="1664597at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045899">
        <property type="term" value="P:positive regulation of RNA polymerase II transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000008">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000027">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000034">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 12" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="167"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="13"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF10131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="390" mass="43804" checksum="A4E099C3FE043387" modified="2013-05-01" version="1">MSDPERDQALEEYKKKLLESREWEAKLKALRLEIKGLQHDFDVSEDNIKALQSVGQIIGEVLKQLDEERFIVKASSGPRYVVGCRSKVDKLKLKQGTRVALDMTTLTIMRMLPREVDPLVYNMSLEDPGQVSFAGIGGLNEQIRELREVIELPLKNPELFLRVGIKPPKGVLLYGPPGTGKTLLARAVASSLETNFLKVVSSAIVDKYIGESARLIREMFGYAKEHEPCIIFMDEIDAIGGRRFSEGTSADREIQRTLMELLNQLDGFDYLGKTKIIMATNRPDTLDPALLRAGRLDRKIEIPLPNEAGRLEVLKIHAMSVQKEGEIDFESVVKMSDGLNGADLRNVVTEAGLFAIKDYRESVSQDDFNKAVRKVAESKKLEGKLEYQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M3AVP9</accession>
    <name>M3AVP9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_110536</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758267.1">
        <property type="nucleotide sequence ID" value="XM_016900849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AVP9"/>
    <dbReference type="STRING" id="692275.M3AVP9"/>
    <dbReference type="GeneID" id="27897986"/>
    <dbReference type="eggNOG" id="ENOG502S3YT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037162_9_0_1"/>
    <dbReference type="OMA" id="CAGWEWV"/>
    <dbReference type="OrthoDB" id="447842at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035539">
        <property type="term" value="F:8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006203">
        <property type="term" value="P:dGTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04678">
        <property type="entry name" value="NUDIX_MTH2_Nudt15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16099">
        <property type="entry name" value="8-OXO-DGTP DIPHOSPHATES NUDT15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16099:SF5">
        <property type="entry name" value="NUCLEOTIDE TRIPHOSPHATE DIPHOSPHATASE NUDT15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="4"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="103"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF10146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="202" mass="22502" checksum="92D29F65CF4E4D45" modified="2013-05-01" version="1">MPPQVRVGVGVFILSSSPSTSSSSPSQTSPNSNPKNPTFLLGIRLNSHGSGTQALPGGHLEFGETFEECAIREVLEETGLQITKPRFLTATNDFILSSSPSFSEKKEGEEEGEDKKEDKKHYVTVFMTCERLNQEDEPENREPEKCGGWEWVDWESLVKWVDDGEEEENKGDGMRKKVFTPLISLIRQRPGLVPSTALSEQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M3AW31</accession>
    <name>M3AW31_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Velvet domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_151278</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the velvet family. VelB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758417.1">
        <property type="nucleotide sequence ID" value="XM_016906713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AW31"/>
    <dbReference type="STRING" id="692275.M3AW31"/>
    <dbReference type="GeneID" id="27903850"/>
    <dbReference type="eggNOG" id="ENOG502S1B4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_571244_0_0_1"/>
    <dbReference type="OMA" id="NVAMDRY"/>
    <dbReference type="OrthoDB" id="1746739at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF3">
        <property type="entry name" value="VELVET COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0749">Sporulation</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="8">
        <location>
            <begin position="203"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF10296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="487" mass="54006" checksum="506D917B52AE3E60" modified="2013-05-01" version="1">MQQHQIPSQPNPYQGHPSSQSHYQSNGIHHDITTRGNDYTNGQQAHGEDMNPYQQQYGGYAPPPLPQSQHQHHQQQQQQQHQHHPHQSQAQSQQQHMRGPPPSMGNPYMQNQLPPLGQPSMGPPMGSMGLVTETPRTHRPSSANPVQPHSYGMPAPPPPMQSMQSMQSLQSLQPPQQSSLPPQPRASNILPNGEKKMSHSNVRDGLKYELHVLQQPQRARMCGFGDKDRRPITPPPCVKLVIIDMNTNAEVSMDDPLLADPSFFILQVDLWAETADREANVVRASSNSPAVSISSATTTSYPPPAEPQRQHFETQQVMYMSEQGPVYAQIPAYPATMARPGYAPSMFYSQMGQPIGYTPQPQQSNAMYTRNLIGSLTVNAARLNDDQGKPGFWFVLQDLSVRTEGFFRLRMSFIDISNKGGGQPGVNRGKAPVLAWTFSDKFQVYSAKKFPGVIESTPLSKCFAGQGIKIPIRKDNKNEAGDDDDGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M3AYJ1</accession>
    <name>M3AYJ1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein L18e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_125757</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760733.1">
        <property type="nucleotide sequence ID" value="XM_016902009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AYJ1"/>
    <dbReference type="STRING" id="692275.M3AYJ1"/>
    <dbReference type="GeneID" id="27899146"/>
    <dbReference type="eggNOG" id="KOG1714">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080024_1_0_1"/>
    <dbReference type="OMA" id="IMGADIC"/>
    <dbReference type="OrthoDB" id="6353017at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000039">
        <property type="entry name" value="Ribosomal_eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17135">
        <property type="entry name" value="Ribosomal_L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="5">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="100"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF12612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="129" mass="14186" checksum="1B5630A8676F5E7E" modified="2013-05-01" version="1">MSLSKIVAVSANKHSAEAQEGKIRAVVGTVTDDNRLLELPKLSICALRFTATARARIEKAGGECLTFDQLALRAPTGSNVLLLRGPKNAREAVKHFGFGPHTDKKPYVESKGRKFERARGRRRSRGFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M3AZA2</accession>
    <name>M3AZA2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">glutaryl-CoA dehydrogenase (ETF)</fullName>
            <ecNumber evidence="11">1.3.8.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SEPMUDRAFT_149393</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>glutaryl-CoA + oxidized [electron-transfer flavoprotein] + 2 H(+) = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13389"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:57378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.3.8.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid metabolism; lysine degradation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Amino-acid metabolism; tryptophan metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.6" evidence="11"/>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760978.1">
        <property type="nucleotide sequence ID" value="XM_016905526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AZA2"/>
    <dbReference type="STRING" id="692275.M3AZA2"/>
    <dbReference type="GeneID" id="27902663"/>
    <dbReference type="eggNOG" id="KOG0138">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_8_0_1"/>
    <dbReference type="OMA" id="HMMNLES"/>
    <dbReference type="OrthoDB" id="435240at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004361">
        <property type="term" value="F:glutaryl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046949">
        <property type="term" value="P:fatty-acyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01151">
        <property type="entry name" value="GCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000003">
        <property type="entry name" value="glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000006">
        <property type="entry name" value="Glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000008">
        <property type="entry name" value="Glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052033">
        <property type="entry name" value="Glutaryl-CoA_DH_mitochondrial"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42807">
        <property type="entry name" value="GLUTARYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42807:SF1">
        <property type="entry name" value="GLUTARYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0274">FAD</keyword>
    <keyword evidence="4 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="16">
        <location>
            <begin position="41"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="15">
        <location>
            <begin position="156"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="14">
        <location>
            <begin position="268"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMF12857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="421" mass="46078" checksum="5A4B6F1719BA2DEF" modified="2013-05-01" version="1">MYKSVVTRAARQLAQPIGRRYVSTPAAFDWRDPLGAAYNFTEEEQAISETAESYCQERMLPRVLEAYRTETYDKKILEEMGELGLLGATIQGYGCAGVSSVASGLITRAVERVDSGYRSGMSVQSSLAMGGIEEFGSEEQKEKFLPEMAKGRMLGCFGLTEPNHGSDPGSMESVAKPHPTKEGYYSLSGSKTWITNSPIADVLLVWAKLQETGKIRGFLIERSKCPPGTLETPKLGDKNGLRASITGMIHMDNLPVAKEMMFPEIEGLRGPFSCLNGARYGIAWGVIGALEDCIARAREYALERKQFKGNPIAKYQLVQKKLADATTDAAFGIQAAYQVGRLKDEGKAAPEMISMIKRQNCDRALMGARNLQEIFGGNAASDEYHIGRHVSNLFVTQTYEGQSDIHALILGRAITGIQAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M3AZR2</accession>
    <name>M3AZR2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bola domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_13113</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BolA/IbaG family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF13007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761128.1">
        <property type="nucleotide sequence ID" value="XM_016902398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AZR2"/>
    <dbReference type="STRING" id="692275.M3AZR2"/>
    <dbReference type="GeneID" id="27899535"/>
    <dbReference type="eggNOG" id="KOG3348">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109462_4_0_1"/>
    <dbReference type="OMA" id="VHAFSQK"/>
    <dbReference type="OrthoDB" id="4983at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990229">
        <property type="term" value="C:iron-sulfur cluster assembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071281">
        <property type="term" value="P:cellular response to iron ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045115">
        <property type="entry name" value="BOL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12735:SF27">
        <property type="entry name" value="BOLA-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12735">
        <property type="entry name" value="BOLA-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003113">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF13007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="100" mass="11205" checksum="89D80670AEAF645D" modified="2013-05-01" version="1" fragment="single">MSARTDLEAEQNQHSSGVTPDTLRSTLEEKLEAQYVDIADLSGGCGQMYEAIIVSPQFAKKTTLARHRLVNSTLKAEIAAIHAWTPKCFTPEEWEKKKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M3B0F5</accession>
    <name>M3B0F5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mannan endo-1,6-alpha-mannosidase</fullName>
            <ecNumber evidence="4 10">3.2.1.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_148627</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Random hydrolysis of (1-&gt;6)-alpha-D-mannosidic linkages in unbranched (1-&gt;6)-mannans.</text>
            <dbReference type="EC" id="3.2.1.101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 76 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.101" evidence="4 10"/>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761393.1">
        <property type="nucleotide sequence ID" value="XM_016905039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B0F5"/>
    <dbReference type="STRING" id="692275.M3B0F5"/>
    <dbReference type="GeneID" id="27902176"/>
    <dbReference type="eggNOG" id="ENOG502RKGU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025694_1_2_1"/>
    <dbReference type="OMA" id="CGSKWYT"/>
    <dbReference type="OrthoDB" id="4187847at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008496">
        <property type="term" value="F:mannan endo-1,6-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000006">
        <property type="entry name" value="Mannan endo-1,6-alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014480">
        <property type="entry name" value="Mannan-1_6-alpha_mannosidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145:SF36">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016302">
        <property type="entry name" value="Man_a_manosd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 10 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004031965" description="Mannan endo-1,6-alpha-mannosidase" evidence="11">
        <location>
            <begin position="20"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR016302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF13272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="432" mass="47629" checksum="D60AB34BEFBF060C" modified="2013-05-01" version="1">MLLATMLAALAAALPIATALDIDVDDPASIRAASQSLAFGLQSFYQNNMSNTASTAIGTLPAPLYWWQAGAMWGGMVDYWAYTNDSSYNAVITQALLAQVGPDWNYMPPAYFASLGNDDQAFWALAVLSAEEYGFPFPAGQRVSRWIDLAIAVWNTQVARWNTTNCGGGLKWQIFQSNKGYDYRNSISNGAFLQISARLARFTGNKTYVDWAERTWDWMDGVGLISSNYQVFDGSDDTINCTQLDHTQWTYNPAVLLYGTSIMANFTNEQVWKDRTEGLLTSIENTFFLPGGDINNSTDVMYEASCEPFGTCNNDQYSFKAYLARWLSKSAVVYPSIADNIAKRLRASAIAAGKSCSGPSQTQSCGQKWYTGGYDGSFGVGQQMSALETVQSLLLLNQTWSPRRAPRSESSVPIEAVPVTSPPKLRPRLRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M3B0X9</accession>
    <name>M3B0X9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_132708</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761523.1">
        <property type="nucleotide sequence ID" value="XM_016902512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B0X9"/>
    <dbReference type="GeneID" id="27899649"/>
    <dbReference type="HOGENOM" id="CLU_1176050_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004031631" evidence="2">
        <location>
            <begin position="18"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF13402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="236" mass="23761" checksum="7BEB0A506BAF9AF2" modified="2013-05-01" version="1">MQLPLLLLAAMASLATAAGPPTADSATTDLTTADTETSGDDTGTNVDNGVPDDAVILQGPDNDAFCFCASFEDITDDNATYYVDNVDTAAICLASDSIVAYYDVGDGKIVAHCQDKTIFQDAQSFADACAEADPLGLNNGAGCCGASPDPCNNFAADPEYIGAGVGGDGGTEGGDPSGGMQAGDVQGGADTAMGTDDQGTDASGQMSADGAEEGNEEGKKEKKGKKSKKPPKSFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M3B142</accession>
    <name>M3B142_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_163182</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761598.1">
        <property type="nucleotide sequence ID" value="XM_016908036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B142"/>
    <dbReference type="STRING" id="692275.M3B142"/>
    <dbReference type="GeneID" id="27905173"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_13_3_1"/>
    <dbReference type="OMA" id="YWCAIFL"/>
    <dbReference type="OrthoDB" id="5215911at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000319">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF30">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04702)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="452"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="490"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="521"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="71"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="272"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF13477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="568" mass="62693" checksum="318C094A5589ADC2" modified="2013-05-01" version="1">MGFFTTNSDSEKENVPSHGLPVPGTVHLVDLEGTMRAKHAKGSLHDVVLVPAPSADPDDPLNWSPARKALSTTCMCIYVLMVGIASAAIYSVLEPISNATGLTLGNLNAGTGYMFLAFGWGCLIWQPLALQYGKRPIYLFSILATAAIQVWAPYTKNNSQWIANKVLQGFVGAPIESLCEISVTDIYFQHERGFYIAVYGLLLAGSNFFAPIIAGFITDGQGWEWVLYWSAIFNGVGFVILFFFMEETNFRREVLFGRENDEGTAETTMTITGKPASLAHSDDEKKTPDSPQVQEAEEQGEAGQASTYTKKSYLDKLKPLRSADIYKPNRLVGMAIRPLIFLTFPVIFYSGFAYGSNLVWFNVLNGTTSLILSNPPYNFRASMVGLTYISCLIGTGIATIYTGWFGDKFVLWLARRNGGIMEPEHRLWLFVPEMILLPFALILWGVGSAHEIHWFGCVFAMGVISLTIVIGLQLSISYCIDSYKDLSGEAIVTVILVRNTMSFAVSYGITPWVTDMGLQNAFLVAAFVGMAQVATFLIFVKFGKSMRRKSAPRYVKYVQQMASDGLVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>M3B2T8</accession>
    <name>M3B2T8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_154926</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762218.1">
        <property type="nucleotide sequence ID" value="XM_016907592.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.M3B2T8"/>
    <dbReference type="GeneID" id="27904729"/>
    <dbReference type="eggNOG" id="KOG1202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_31_1_1"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05274">
        <property type="entry name" value="KR_FAS_SDR_x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF29">
        <property type="entry name" value="ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23297">
        <property type="entry name" value="ACP_SdgA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22621">
        <property type="entry name" value="CurL-like_PKS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="8">
        <location>
            <begin position="7"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="9">
        <location>
            <begin position="1029"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="2538"/>
            <end position="2612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="463"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="5">
        <location>
            <begin position="1029"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="5">
        <location>
            <begin position="1196"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="479"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="5">
        <location>
            <position position="1061"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="5">
        <location>
            <position position="1266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF14097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="2617" mass="284564" checksum="FAF20D1A86B3C7A7" modified="2013-05-01" version="1">MTSQHAAEPIAIVGMACNFPGGADSPEKFWEMLKSKRSAWTDTAPSDRFNFDAHWHPKSDTNGTFNIHGAHFLTQDVAAFDAPFFNISAPEAKAIDPQQRLTLESVFQAMESAGITTEKLAGSRTSVFVNLYNLDYSYITTRDPEDISKYQTVGTGSALMANRISYFFDLRGPSITLDTGSSGSLVAFHEACQSLRTGEATTAIVAAATIILDPLPMVGMTHMNFLSPEGRSFTFDDRASGYGRGEGVAAVIIKPLKLALADGDPIRAIARASYCNQDGRTPGITMPSQQAQMDLIRGAYESAGLSMEDTIYCEAHGTGTAAGDPVEVSAIGSTIAKCLREKRGGRTLVIGAAKSNIGHLESCANLAGLIKVVMMLEKGWIVPNYDFQRPNPEIDLKGLNLEVATHLQPLANPSAIFLRASVNAFGYGGTNAHVILDDARGYLRAHQLEEYLERLPPMNGDDGHDGINNHNGLNGHNGGDGHNEIKGHDGDDGHNGINGHDGIDGHEGLNGQNGIDGRNERDGHNGLVAHNGSSEDGEVPADKTRIFMLSAKTARALAARKKAIASYVQDHTRSRLDLDSLAFTLNTRRTHFLHRDYVVASTQDDLVHALRGPAPAKSATAASVGGNVPRVAFCFTGQGAQWAQMGVDLIEHSPHFRHSLEQCEAVVTELGASWSLWEELHASADVTRVNEAELSQPLCTAIQIGLVDMLSVVGIKPDVVFGHSSGEIAAGYASGALSLYGAMKIAYFRGVCASRIKATAAPTQLQGAMLAVGLSQDAVETYLDVVPSKLGQIVIACVNSSSSVTLSGDVAAVEYVHKRLTEGGHFARRLRVDIAYHSPHMQRIAQAYHEALGDLKTHELNSTTTFVSSVHAMVIESSSLLDAAYWVSNLVSQVQFSAAVETLVQDVINHKEEWHKVLIMELGPHPALSGPMRQTLQEVAAPELDYQIFPSLVRNSSSTHSIFSLIGSVFCARGTLDLSAAQLGGDTLKGKLLPRVLTDLPSYPWDHSVQYWHESRISAEYRLRTRPKHPLLGVPSIDFDHLQPSWRHIIRTTELPYLRGHVIQSDILYPAGGFVAAVLQACYEHWLALGHIHPIERYVLEDVLIKQALPIADDGAGVEMKTILFPRFKMAQGMKTRDLQYNFVIRSCTVDGQWSEHCEGSARMLLSDGSGTTTTTTTTRQQTTSQKLQAFHKAEAEIPTWVRRTKQNLYADLRGIGYFYDGAFQALDEVFTKPNHAFAMLSIPETSRFMPMEYEPPQTLHPATIDGFFQAPLCALFEADQLRNTMVPQRLGRLEVDARIHHTAGVKLLISTSAVLKGHRSCDVEFHVKNEAWPDDILVSGADIEYIGLGSWQDAQVQQDRAALCNRFETGPVVRFLRPGEFQRLLEVDDSNQVNGTVNTGALENAALSYIRTALEALQSWKPTNETPHHLMKLFESFKDVHATRGGVQKSCDIQPVSKALVNGNLHLPTAMEELVHRVGPRLAEIIIMGTQDPNALLQQDDLLDRALHEHRGLQKCQQSVQRIVEALLFEQPKLRVLEYGNMIAEPSRYLADILSSPDVTYDYTGHPSGLFSIASSHDATGHVHVRRMNIEEEESDGEGYGDRKYDLVVLSSSLHLCASIDKALSNIRRLLNPHGVLVILDVLEPQLYLDMVMGTLPQWWRAQENHRQGSPVLDLHGLDCALKQNGFSGAVLKSAPESISASATTPYGVVATCVEPTTGSGGSQYRVHLLATSSAIPVEDSLVEAVKTQTLLDVEQSTFDIAGQAGCVYVIFDDGPEGLLENPTSGAFAAMKRIVASAQGIIWLTRRTDVTLSNAPLPSSGVVGLARVVRTEYPLLPFLTVELGSDPAGYEMRRVDAVVKMLKHLQTITAISTEAGSSLDSEFSEEEGALCVTRLLAHEHASKFVSGDTERQLERRSEMHDDSSLGIKRLTMATAGQLSTLCWEAIQGSSTPSLLPGPEELAIEARAFGVTPGDLRTALVDGGHRSWLGAFSGVVTAIGSSLHGQFHLGDHVLGYLPVGFTTRAVVNAAAVRKTLLPFEEAAAIPGLYTSIAYALTSVAKVRAGELVVVSIESGLIRDFAVQYAKYLGASVFIFDDSETLTDEQGIDIILWHQYAGKSTGPGCRDLRSRLRSGGRIIDISSFDNSEESAPATELAAGSKNVTFISIDWNDLVVSSVGLAGGHLLDEALMAVEALGIDIPMSSHSWADVFTAFRSLQHDSSSANHILRVEAHKEVPVIDATRPFRLVPDVTYLLAGGMGGLGRAIVAWMYEHGARNFALMSRSTPIDGSKEAEWLRIMNARGCNVQLFTCDISSADEVQRALGIIGSKMLPIGGVIQSAMVLRDAIFENMTENAWAATVEAKIQGSLNLHRLVAQQKQLGFFIMLSSVAGIVGNAGQANYAAGCAFQDALARYRIAQGLRATSLDLGMIQTAGYLENNVHVAESLLRQGFRPVKLEHVFRLLRFAMQDQAQHSQIAIGIQYDYTSGSGNNTAKRPEFLRDARFRHLVRLSDSAISHNVAHASIKDSLRAAASPQEAHAMVTEALLRLLADKIGLSREDVSKDQSIIDLGVDSLVAVEIRTFVIRELESEISTAELLGSDSISSQAERVVTRRKKVNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M3B6P3</accession>
    <name>M3B6P3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_123758</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL43 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763583.1">
        <property type="nucleotide sequence ID" value="XM_016901859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B6P3"/>
    <dbReference type="STRING" id="692275.M3B6P3"/>
    <dbReference type="GeneID" id="27898996"/>
    <dbReference type="eggNOG" id="KOG3445">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117700_1_1_1"/>
    <dbReference type="OMA" id="ISKWIDL"/>
    <dbReference type="OrthoDB" id="88at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000173">
        <property type="entry name" value="Mitochondrial 54S ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039927">
        <property type="entry name" value="Ribosomal_mL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21396">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21396:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="7">
        <location>
            <begin position="32"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF15462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="138" mass="15311" checksum="2A4EE3836D3E4065" modified="2013-05-01" version="1">MPLAALRTVAKPQNGVGAFILQCKRLDFHYCDWAGSSRGLNAFLKSRLAAFAAANPSIEITVSPRPGRHPVITGTYINGRTKPVCVRNLDTNEIMQKVLLLRNANGEKLRRVTKPVKSLNESVRGVWSPYHVAEPYKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>M3BPQ9</accession>
    <name>M3BPQ9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_167215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF08158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756279.1">
        <property type="nucleotide sequence ID" value="XM_016908280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BPQ9"/>
    <dbReference type="GeneID" id="27905417"/>
    <dbReference type="HOGENOM" id="CLU_2706398_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF08158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="73" mass="8021" checksum="320BC0C0ECDE5E95" modified="2013-05-01" version="1">MVHGPSVRAVPDDSSLLSGQHACPIQRVPHWKLLVFPLELPLLLVLWYMIVSSAHLSSFETGGSAMDRKLAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M3BPW0</accession>
    <name>M3BPW0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-ribulosamine 3-kinase</fullName>
            <ecNumber evidence="1">2.7.1.172</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_152458</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>N(6)-D-ribulosyl-L-lysyl-[protein] + ATP = N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48432"/>
            <dbReference type="Rhea" id="RHEA-COMP:12103"/>
            <dbReference type="Rhea" id="RHEA-COMP:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:90418"/>
            <dbReference type="ChEBI" id="CHEBI:90420"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.172"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:48433"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fructosamine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.172" evidence="1"/>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF08203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756324.1">
        <property type="nucleotide sequence ID" value="XM_016907455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BPW0"/>
    <dbReference type="STRING" id="692275.M3BPW0"/>
    <dbReference type="GeneID" id="27904592"/>
    <dbReference type="eggNOG" id="KOG3021">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036517_0_3_1"/>
    <dbReference type="OMA" id="RECDIAM"/>
    <dbReference type="OrthoDB" id="5772781at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102193">
        <property type="term" value="F:protein-ribulosamine 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1200.10:FF:000018">
        <property type="entry name" value="Fructosamine-3-kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016477">
        <property type="entry name" value="Fructo-/Ketosamine-3-kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149">
        <property type="entry name" value="FRUCTOSAMINE 3 KINASE-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149:SF8">
        <property type="entry name" value="PROTEIN-RIBULOSAMINE 3-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03881">
        <property type="entry name" value="Fructosamin_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006221">
        <property type="entry name" value="Ketosamine-3-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR006221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF08203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="326" mass="35432" checksum="7E22AC03FF1C50B9" modified="2013-05-01" version="1">MTLDSALLSLLHLSPDQVTTSSHGGSSFSKTSKITATLPDGTTKSFFMESGKGRDAQTMFQGEHASLNAIHNAVPSFCPQSFGCGPFSDSQDTYFLVTDFLDLSPAGKHTPSGPSLAQKLAKLHTTPAPPPAGYEKPQFGFPVTTCCGDTPQDNTYSSSWADFYADSRMRAIIARSRQRNGKDHDLENLGERLCDKVIPRLLGDDHLNQGKGITPVVVHGDLWSGNTSTGKLPSMSSPEAVVYDSSACYAHSEFELGIMNMFGGFGGTFLKEYHEMVPKTEPVAEYPDRVKLYELYHHLNHHAMFGGGYRSGAMSIMKDLVGKYGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M3BQ99</accession>
    <name>M3BQ99_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_152011</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756439.1">
        <property type="nucleotide sequence ID" value="XM_016907186.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.M3BQ99"/>
    <dbReference type="GeneID" id="27904323"/>
    <dbReference type="eggNOG" id="ENOG502QW48">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003774_0_0_1"/>
    <dbReference type="OMA" id="CRREGKM"/>
    <dbReference type="OrthoDB" id="298344at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018866">
        <property type="entry name" value="Znf-4CXXC_R1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10497">
        <property type="entry name" value="zf-4CXXC_R1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="JmjC" evidence="6">
        <location>
            <begin position="170"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="559"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="759"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="847"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="994"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1061"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1362"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="559"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="569"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="929"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1003"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1024"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1064"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1102"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1153"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1191"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1239"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1266"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1308"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1319"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1363"/>
            <end position="1374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF08318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1383" mass="153072" checksum="294457AE35231D93" modified="2013-05-01" version="1">MPAQRPRASFEPIAPNFDLKALVESTANFTYVDRISCEMIEAQGMAAFEKLILLHVIVGGKPLVIDGFEEKLDPWTFTPKWLRDNCGEKVENARNLTAKENLPLTMGHYLKNMGLLTNQFFDKPGAYKEKTRQRVYLKDIDCPPVWWDKLKDHLPAAVTYLNDSTGEIGGPGAKPDPQSTVPGRRLGKGIARAGDLMSSLPPDMRAENLMCYIGHEGTYTPAHREMCASLGQNIMVEASGTVSDDGKAEKPGSSIWFMTESKDRHAVSEYFLSILGHDIEVENHFAQVVAWKKAPFSVYVVEQRPGDFILIPPLAPHQVWNRGTRTMKVAWNRTTVETLEMALNEAIPRSRIVCRDEQYKNKAIIYYTLQKYHSLLLDAQRQASLMPRDAAHSFLYTGKIKQLTKDFKRLFGLYKQILLTEMFSPEDRDSPKNLEYLPFDSNVTCAYCRANIFNRFLTCPCCKDMLGHNADTEDGDPYDVCMDCYAMGRSCYCISGLKWVEQFKWKELVSKYEVWRKVIIDLDGGQITSKTPVPLIEERRRYGKKTLAEVCKDQLRRRPFKDPHKSDEPKEDTESEEEIEVGDDGTVKKVTKKKSKSWLKNNKACHICCHRHPAWKMAQCTTCDRAWCYGSLFRGWDKMPLEIMENPDWSCPHCLEVCFAGACRREGKMIPYEPKGTLLGHDTKKVADVRSVEVLVDFSVSNLNWLKEDEQGNKIESRRMQKARQAGADLGENMNELRRDLERSDDDGGVDGTQLEMEYSPVRDGPLDPALGGDAIPSGSRHIMSGGLGDLDDEAALARRLQLANASLPGSAGKVAKSAVNGGVPEGYAPLTAAGYAGYAPEASMYPDPDGGASYHYPGQNGDDDETPGTGKRDKGKKRKNRKSGEADDDDEDIAMSKAPKQKKPRLQAAGFRSQDLAEEATGASASKAKNEAQRQFEKEKERKALEKAKAEGRFIMLQAAIKGKKRIVRLPIPGNRLGQVIAQQAAKAAFTTAHGPEADAEHEMEDGADEDEDQHGLLLKSDIAPKKNPETREQRLRNGIIVSGGAKKALVPVDNDESYGYSYRERLPNGQRVKRDLTKQQPTLASNKARRKSQKQATVYEEVDIGSDDDVGVGEENSFVAINSTAGRNRRSLPGYLQNRHEDGDPDAPNKLPDDIRDRSQKQRPSSTQRKRQSATGPDAQLIQETEDTASASADPSPAKNSPQPAAPSSKKAGRPSFGGKGPAMRPSTVSEPITIDDNGESSDDDFLDEAISEAANGEGIPSNGLPTTNGYASHSTSSSKPKGRPSQALPSQAELAAKQAAEEAQKQALMQAAEQAEQQRERDEANRLAKLQALQMLESGGDMDLDALDNNRAGGGVEFADQFEDESDDGADEIPARPVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M3BQQ4</accession>
    <name>M3BQQ4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_136593</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756554.1">
        <property type="nucleotide sequence ID" value="XM_016902786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BQQ4"/>
    <dbReference type="GeneID" id="27899923"/>
    <dbReference type="HOGENOM" id="CLU_1836400_0_0_1"/>
    <dbReference type="OrthoDB" id="1938138at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF08433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="140" mass="15764" checksum="7959DDE1D2E4F9D6" modified="2013-05-01" version="1">MHLDTGMKRQLCIGTACLGSRLEISYRFHCSIKQSRVRRRSGHIHIFMLRGDIVPSLLYAIRLDWLYIATSTLHPFRLRPCGVLYSRFHFLALDLNTVPRAGGGTYLKRNPSLIGVDSALLRHIYTSAAISAFCFIAAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M3BRA6</accession>
    <name>M3BRA6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Guanylate kinase</fullName>
            <ecNumber evidence="2">2.7.4.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">GMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_167035</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the guanylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.8" evidence="2"/>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756774.1">
        <property type="nucleotide sequence ID" value="XM_016908272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BRA6"/>
    <dbReference type="STRING" id="692275.M3BRA6"/>
    <dbReference type="GeneID" id="27905409"/>
    <dbReference type="eggNOG" id="KOG0707">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001715_0_1_1"/>
    <dbReference type="OMA" id="NFITHEV"/>
    <dbReference type="OrthoDB" id="6334211at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:GMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046711">
        <property type="term" value="P:GDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00071">
        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000776">
        <property type="entry name" value="Guanylate kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017665">
        <property type="entry name" value="Guanylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03263">
        <property type="entry name" value="guanyl_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117:SF13">
        <property type="entry name" value="GUANYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117">
        <property type="entry name" value="GUANYLATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="10">
        <location>
            <begin position="9"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF08653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="198" mass="22164" checksum="C05657718BA30256" modified="2013-05-01" version="1">MAPTGNSKPRPIVVSGPSGSGKSTLIKRLRAAYPDRFALSVSHTTRDPRAGEEHGKDYWYVSKDEFKKKVDENGFIEHAQFGSNFYGTSVQAVKDVAEQGRTCILDIEMEGVKQVKKTDLNARYLFLQPPSVEILEKRLRGRATDKEEAIQQRLTQAAVEIEYSKTPGVHDQIIVNDDLEKAWKEFEAFCVPESASSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M3BT60</accession>
    <name>M3BT60_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ADP-ribosylation factor GTPase-activating protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_150963</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">GTPase-activating protein for the ADP ribosylation factor family.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF09850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757971.1">
        <property type="nucleotide sequence ID" value="XM_016906506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BT60"/>
    <dbReference type="STRING" id="692275.M3BT60"/>
    <dbReference type="GeneID" id="27903643"/>
    <dbReference type="eggNOG" id="KOG0521">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002728_0_0_1"/>
    <dbReference type="OMA" id="ITPNAFP"/>
    <dbReference type="OrthoDB" id="10266696at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08204">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07608">
        <property type="entry name" value="BAR_ArfGAP_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000051">
        <property type="entry name" value="ARF GTPase activator (Csx2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000252">
        <property type="entry name" value="ARF GTPase activator (Csx2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000017">
        <property type="entry name" value="ARF GTPase activator (Csx2), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045258">
        <property type="entry name" value="ACAP1/2/3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180:SF160">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN EFFECTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180">
        <property type="entry name" value="CENTAURIN/ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16746">
        <property type="entry name" value="BAR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="660"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="domain" description="Arf-GAP" evidence="8">
        <location>
            <begin position="842"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="245"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="553"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="799"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1020"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1086"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="582"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="592"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="625"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="799"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1021"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1037"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1138"/>
            <end position="1149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF09850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1149" mass="126278" checksum="1AC21C62716ADD14" modified="2013-05-01" version="1">MGIVSSRPDDGASICLSDQARFSIASIIVTNSRGQTLLRVAPNAYPATRFSASKDTGDDSPLKYVQDPESLLTGMPAFLIRLSNTDELNFHFLFILRQQGQSAANSNSTSPTATTFDTTISGLTYVFASTPKEVDHLVVREFHTDPNLHKNANVQLVGDFSTAGNASVQFGWSWKWRPPKQSEDRGGGWRNSCSFVEYNQRSHKLETLASFSFWVQNTQRILSASPRSPMLNVDLPNMPARLRVPSTQSIESRVSNVSDSEGESNYQDHKNKDMPQSPTFEPIPENGLGLIPTLTAQSMAGLVKVDVATCKPGEDPSLNEDGPLFRATMRSLEQKTSNMRTRMKKVLKTAEAAESAQQACNQAVADFTNALRDAATSNANAVQPALDHYFEKIAKEILHYEKQNTVNLQKLIIEPVSKLYNFEIKQADSKKREFEEESKDYYAFVGKYLGQRTESLKEKKVVRSDEKYQSKRRTFELKRFDYSSFMHDLHGGRKDQEVLSHLTKYADAQAKSYLTTAKKVEEMVPQLDALVAEVRMADQDFKLLRQEREEKRRALETSTKLTSEDGNVAPTGGLTHSTANRDSLRPGDLHPTRSTSLSGSAILSQSPPSAGGLAAQQPTSNGLLSTPASSTSTTAASPASKFKGIRDLEDNSGATANGGAMRKEGLLWALSRPGSHVDPKGITKPGWHKFWIVLDQGKLSEYVNWKDKLDLHMEPIDLRMASVREARNADRRFCFEVITPQFTRVYQAPSEDDLRAWIGAINNALQSAFENKNQPLPASPSPAVNSHRKDIAAVLTGKSSSFSGHRQVSNPNRHSASGAVSRHATTGDKPAYKRVDSEPEPSALLQRIKNADEGNRVCADCGSDAKVDWCSINLGILLCIECSGIHRSLGTHISKVRGLTLDTSFATHDIVEVLLLIGNRVSNMIWEAKLDRFLKPSPHSTRDQRLHFITAKYSDRTYVQTPAAPMSPDEYLLTSIKKNDIQSVLHALALRANPNAHDRVRATHAVYLALAAADPAAPASGYTSSIRATSGSSVTAPPRPSSPLPRKPFPLAEVLLQNGADIPSEPSPFPLSDHARMYLELKKEQRLGKTESSAGMEANGDNLMPLPTAAMGASPSASLSRDRDKLLHRNSSGRPKSRASDAIEGFVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M3BT72</accession>
    <name>M3BT72_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_150970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF09860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757981.1">
        <property type="nucleotide sequence ID" value="XM_016906512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BT72"/>
    <dbReference type="STRING" id="692275.M3BT72"/>
    <dbReference type="GeneID" id="27903649"/>
    <dbReference type="eggNOG" id="KOG1502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_12_2_1"/>
    <dbReference type="OMA" id="FNDYEGV"/>
    <dbReference type="OrthoDB" id="2130169at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="343" mass="37797" checksum="700035DF0322DDED" modified="2013-05-01" version="1">MPPQLFITGITGYIAGDAFYAIHKAHPDYKYVALIRTEEKAGKVRAAYPDVRVVIGGLDDSAIIEEESAKADIVLHAADASDHEGAAKAIAAGLLRGHSAHKPGFWLHTGGTGILTYFDSSKERFGEEPEREFNDYSGVKELTTLPDEAFHRNVDKIVLEAGTKHGDVIKTALVCPPTIYGRGRGPVSGRGRQAYELTKTILQKGYAPIIGQGRAHWDNVHIHDLSEVFLALVDVAVQKKLDSEIWGEKGYFFVANGRHVWGDLSRLIAKKAAEAGHIPKDFKEQKLSKDEAWGLADFQALSWGLNSQGKAERARKVLGWQPREISLEDEVPAIVEQEKKRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M3BT76</accession>
    <name>M3BT76_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_158103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF09865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757986.1">
        <property type="nucleotide sequence ID" value="XM_016907768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BT76"/>
    <dbReference type="STRING" id="692275.M3BT76"/>
    <dbReference type="GeneID" id="27904905"/>
    <dbReference type="eggNOG" id="KOG0581">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_460170_0_0_1"/>
    <dbReference type="OrthoDB" id="310217at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053083">
        <property type="entry name" value="TF_kinase-domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44305">
        <property type="entry name" value="SI:DKEY-192D15.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44305:SF24">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE C03B1.5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="214"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="593" mass="67962" checksum="632BACDFFA08CFF9" modified="2013-05-01" version="1">MYTQLLSTLSIMATDPVYSKHLEWALSFFADEARREEHRKQAKAIWKNDIPTPDQINFRTQIESMEEAKATGAEMAEVWETHIKDRDWDSKWAPLLAKHVDEMEDIEVNELAAYMRVLGAYIYAIKSYRVTLERLMQTYVDFGLDHVFAPKTHENLTAAKGGEAAHVDSGQWDYVATVCNSPEFKARMKETMDAGTLSMFIDEFDEKKIWVAAIDLDEGLGKSVKLWVWLAFDERGNIVDRHVSKCEQLEEPWWSMPRYWHTYGNGEVLPMESYLSRKCWAEDNTAFVNHQSYLWNEEEHWVEFRMDYCPYGDLNGLYHTYRRENVPIPEPILWMIFQKLVEQCLIMEKGSVLANTSIPGWRQIVHRDIKPENVFVDVPSTNGFFPAYPTPKMADFGFAFETSPQDPTNPDQWSRAGTRPYLAPEQMGLSVIEDPNEAPVGIKLLAHTNIWGIGMLLLRLTNGPFPLDEQKKPIPFWSPTTNTMNLPGHETSLWAETHYSENLLALIRKAIVPEPYLRPTPQALLHWVVTEMEKVSDGVGEYCRAAKKGAQPGGIGEGEFGWLVGREKYKIALARDGGDEGMSLRTALEALRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M3BUQ3</accession>
    <name>M3BUQ3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_150096</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759190.1">
        <property type="nucleotide sequence ID" value="XM_016905960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BUQ3"/>
    <dbReference type="STRING" id="692275.M3BUQ3"/>
    <dbReference type="GeneID" id="27903097"/>
    <dbReference type="eggNOG" id="KOG1204">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_11_1"/>
    <dbReference type="OMA" id="SHVDEWR"/>
    <dbReference type="OrthoDB" id="153074at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05367">
        <property type="entry name" value="SPR-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000281">
        <property type="entry name" value="Uncharacterized oxidoreductase YIR035C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF8">
        <property type="entry name" value="BENZIL REDUCTASE ((S)-BENZOIN FORMING) IRC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="3"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF11069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="253" mass="27378" checksum="6210FC8854DA78C4" modified="2013-05-01" version="1">MSKVIVVTGASRGIGLAISHYLLQHSHKVTLVARSEAPLRDLEGQYPDQTAILTGDLADLSLGQKAINLTIQTFGKLDGVIVNHGTLDPVSRVADSSAEAWRNAYNINFFSAVALATAAIPHLRSTTGTILFTSSGAAATAYPTWGAYGSSKAALNHLAQSIAAEEKEAGVTSMAIRPGVVDTEMQREIREKHHEVMEESDRKRFKELKDTGALLRPEQPGWVMAKLVLEAPRELSGKFLSWNAEELKAFQEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M3BUT1</accession>
    <name>M3BUT1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Post-GPI attachment to proteins factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_164676</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the lipid remodeling steps of GPI-anchor maturation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PGAP3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759220.1">
        <property type="nucleotide sequence ID" value="XM_016908126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BUT1"/>
    <dbReference type="STRING" id="692275.M3BUT1"/>
    <dbReference type="GeneID" id="27905263"/>
    <dbReference type="eggNOG" id="KOG2970">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032917_1_1_1"/>
    <dbReference type="OMA" id="DFMIEDC"/>
    <dbReference type="OrthoDB" id="419770at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007217">
        <property type="entry name" value="Per1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13148">
        <property type="entry name" value="PER1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13148:SF0">
        <property type="entry name" value="POST-GPI ATTACHMENT TO PROTEINS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04080">
        <property type="entry name" value="Per1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2 7" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016485483" description="Post-GPI attachment to proteins factor 3" evidence="7">
        <location>
            <begin position="28"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF11099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="333" mass="38804" checksum="0F59E02694DB4AB4" modified="2013-05-01" version="1">MRQQTWQKCWLLLIASTLALFAGVTTASLGDHLPEFRECVEDCKEANCGENGLSIPLLHRLLLWTCPSECDYACQHVVTDQRLTRDPPYLSPVVQFHGKWPFYRLFGMQEPASVLFSLFNFMAHQNGINKVKEQIPSRYALRKYYLGFGYFGLVTWTFSMIFHMRDSGVTEKLDYFAAAASVMYGMYYAPIRIFRLDRKDIFGSRTGTVLRLWTLLCLGLYSCHVGYLTFIRFDYTYNMAANVVVGVITNVMWTWFSVSRFRKVGRLWAAWPGLIVFWIIFAMSLELFDFPPWWGMVDAHALWHLGTVIPTVWWYNFLLKDASEDLQAERLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M3BWY1</accession>
    <name>M3BWY1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dipeptidyl-peptidase IV</fullName>
            <ecNumber evidence="4">3.4.14.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Dipeptidyl peptidase IV</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SEPMUDRAFT_108059</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.</text>
            <dbReference type="EC" id="3.4.14.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S9B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.5" evidence="4"/>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760677.1">
        <property type="nucleotide sequence ID" value="XM_016900717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BWY1"/>
    <dbReference type="STRING" id="692275.M3BWY1"/>
    <dbReference type="GeneID" id="27897854"/>
    <dbReference type="eggNOG" id="KOG2100">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006105_0_2_1"/>
    <dbReference type="OMA" id="YTSTEHH"/>
    <dbReference type="OrthoDB" id="16520at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000003">
        <property type="entry name" value="Dipeptidyl peptidase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.140.10.30">
        <property type="entry name" value="Dipeptidylpeptidase IV, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050278">
        <property type="entry name" value="Serine_Prot_S9B/DPPIV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731:SF162">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731">
        <property type="entry name" value="PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004031451" description="dipeptidyl-peptidase IV" evidence="14">
        <location>
            <begin position="28"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="domain" description="Dipeptidylpeptidase IV N-terminal" evidence="16">
        <location>
            <begin position="111"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="15">
        <location>
            <begin position="577"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMF12556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="801" mass="90485" checksum="1D33E32BB283E2CF" modified="2013-05-01" version="1">MALRRLRTRPTWCAAFLLALSSCGVHAIDPPRQPRQPLGNGTRRLTYNETTPTAQNRATSQTVSWISSEQDGTFITTANGSLVLENIVTGDSSVFVAADKVPADYHEYWISPDQERVLWAVNYTKQYRYTYFADYLIQDVATGETTPLVPDQLGDIQYAEFAPTGDAIAFVRDNDLYIHHNDSQITRITDNGGPDMFNAVPDWVYEEEIFGITKTLWFSPDSMYIAFLSFNETGVGTFRIPYYMDDQDIAPPYPRELELRYPKVGTTNPTVQFNLLDMTTKQYSNIPVTAFPPDDTVIGEVAWVTEDHSAVIYRAFNRVQDQDKHVLVDPVAKTSEVVRERDGTDGWLDNTGAITYVGPIEFNTNGTATYSNTSAPAYYVDESDESGWMHIYLHPVTGGESIPLTSGEWEVVSILKVDTSRNLIYYTSTEHHSTERHIYSVNYATGEKKAIVDDTVDAYWSASFSSAGDYYILSYQGPDVPYQEVYSVNSTEALSVLVSNEALVQNISALHLPNITYFELEHPEGFRLNVMQRLPPNFDPSKRYPVLFTPYGGPGAQEVSKRFQTLAWRAYISSDPELEYITYTVDNRGTGYQGRAFRSAVTRHLGRLEPQDQIWAAQQLIAQNSFIDTERVGMWGWSFGGYLTAKVLEADSDVFSFGLITAPVSDWRFYDSMYTERYMKTYEQNPEGYNETAVRNADGFKHARGGFGIMHGTGDDNVHYQNAAALIDLLVREGVSPEKMEMVAFTDSDHGITFHGASAWIYKYLTKRLWEEKERKVGLVDQTHQWLRKRAAVVEGGGVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M3BYI2</accession>
    <name>M3BYI2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_148503</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761242.1">
        <property type="nucleotide sequence ID" value="XM_016904961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BYI2"/>
    <dbReference type="STRING" id="692275.M3BYI2"/>
    <dbReference type="GeneID" id="27902098"/>
    <dbReference type="eggNOG" id="KOG2624">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010974_5_1_1"/>
    <dbReference type="OMA" id="WRMYNEI"/>
    <dbReference type="OrthoDB" id="9974421at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000095">
        <property type="entry name" value="Triglyceride lipase-cholesterol esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006693">
        <property type="entry name" value="AB_hydrolase_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04083">
        <property type="entry name" value="Abhydro_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Partial AB-hydrolase lipase" evidence="9">
        <location>
            <begin position="84"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="470"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF13121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="564" mass="63048" checksum="736A754C7358EE10" modified="2013-05-01" version="1">MAPIPLIGRLYVHEFLALAASFAIALLEVVARTITLLLPTPIIRGLYRLSRNAFNSLSSPYSRRARNKKRNVSSPIAQAHDFLELCELYGYLAEEHVVQTGDGYLLGIHRLAHRRGEEDQRVNAGPGSVEKKVVYLHHGLMMNSEVWVCLTEEERCLPFLLVEQGYDVWLGNNRGNKYSKKCLHYGPTENKFWNFSIDQFAFHDIPDSINYILDTTYQPSLSYIGFSQGTAQAFATLSIHPTLNTKVDVFVALAPAMAPPGIASGLVSSLVKSNPEVLYLLFGRRAILGSTTMWQALLYPAIFSWVIDKCLRFLFGWKALNIAPHQKIAAYPHLFSFTSTKSVVHWFQIIRNGKFQMFDDEVTSPTSFSTGSKYYKVAKFPTKNIRTPIVLVYGGSDSLVDIKLMMKELPRHTIAKCIPKYEHLDLLWASDVDKLVFPHVLEALKSYSQQGQAKQQALGWRTTRPSLLDGAAVTPNGSAPPGYSDEEGSHNHSLNGYQGTAFADERLSNSEAQLDESDDDDDIYLDETPLTFTPYAFSNSSRVPTIDAATGIRPAPLEITGRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>M3C0K7</accession>
    <name>M3C0K7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_149006</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761977.1">
        <property type="nucleotide sequence ID" value="XM_016905280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C0K7"/>
    <dbReference type="GeneID" id="27902417"/>
    <dbReference type="HOGENOM" id="CLU_2307829_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF13856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="100" mass="10756" checksum="16E3BE6D2E49D220" modified="2013-05-01" version="1">MMPGTGLNSRNLLYLPGLGRVMNGTASTGLLLLAGWRLGMVPIPDSSGHATVEPVSLAHPSSWSLMRDVPYPPSDKVEELPPSWSCCRGLIQVGFPVIYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M3C2H5</accession>
    <name>M3C2H5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Heme haloperoxidase family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_148157</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762572.1">
        <property type="nucleotide sequence ID" value="XM_016904745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C2H5"/>
    <dbReference type="STRING" id="692275.M3C2H5"/>
    <dbReference type="GeneID" id="27901882"/>
    <dbReference type="eggNOG" id="ENOG502QTVQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050230_6_0_1"/>
    <dbReference type="OMA" id="TFQPAML"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF18">
        <property type="entry name" value="HEME HALOPEROXIDASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="8">
        <location>
            <begin position="28"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF14451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="224" mass="25573" checksum="17123EB691431C32" modified="2013-05-01" version="1">MRSQTTVSCKMPPPDMIWRDSFLTTCRPRDGKNITIAQVEEALMQHLHMDRALVSSIARPLNQILHPDHTFDLIDMRRHNVIEHDASMTRLDARQGDNYTFQPAMLQAMLEDAEGGPVTVKTLATSYNRRRRERQADGGAPIPLNLWFVNIVQTVSFLNTAADATGDDGGGEAELSSDVLKLFYEEERISDVILDNHQTRTLSSLLWNASKLMFYVAMGYYRWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>M3C2X0</accession>
    <name>M3C2X0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Pentafunctional AROM polypeptide</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="14">3-dehydroquinate synthase</fullName>
                <shortName evidence="14">DHQS</shortName>
                <ecNumber evidence="14">4.2.3.4</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="14">3-phosphoshikimate 1-carboxyvinyltransferase</fullName>
                <ecNumber evidence="14">2.5.1.19</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="14">Shikimate kinase</fullName>
                <shortName evidence="14">SK</shortName>
                <ecNumber evidence="14">2.7.1.71</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="14">3-dehydroquinate dehydratase</fullName>
                <shortName evidence="14">3-dehydroquinase</shortName>
                <ecNumber evidence="14">4.2.1.10</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="14">Shikimate dehydrogenase</fullName>
                <ecNumber evidence="14">1.1.1.25</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="20" type="ORF">SEPMUDRAFT_39665</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21256"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="EC" id="2.5.1.19"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21968"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="EC" id="4.2.3.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>shikimate + ATP = 3-phosphoshikimate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13121"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.71"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>shikimate + NADP(+) = 3-dehydroshikimate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17737"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="14">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="14">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="14">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="14">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="14">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the 2nd section; belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the 3rd section; belongs to the shikimate kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the 4th section; belongs to the type-I 3-dehydroquinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the C-terminal section; belongs to the shikimate dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the N-terminal section; belongs to the dehydroquinate synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.4" evidence="14"/>
    <dbReference type="EC" id="2.5.1.19" evidence="14"/>
    <dbReference type="EC" id="2.7.1.71" evidence="14"/>
    <dbReference type="EC" id="4.2.1.10" evidence="14"/>
    <dbReference type="EC" id="1.1.1.25" evidence="14"/>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762742.1">
        <property type="nucleotide sequence ID" value="XM_016908756.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.M3C2X0"/>
    <dbReference type="GeneID" id="27905893"/>
    <dbReference type="eggNOG" id="KOG0692">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001201_1_2_1"/>
    <dbReference type="OMA" id="SWANMSW"/>
    <dbReference type="OrthoDB" id="197068at2759"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="F:shikimate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00502">
        <property type="entry name" value="DHQase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08195">
        <property type="entry name" value="DHQS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01065">
        <property type="entry name" value="NAD_bind_Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1090.10:FF:000007">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000135">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1970:FF:000007">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="entry name" value="Enolpyruvate transferase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018508">
        <property type="entry name" value="3-dehydroquinate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016037">
        <property type="entry name" value="DHQ_synth_AroB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030960">
        <property type="entry name" value="DHQS/DOIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056179">
        <property type="entry name" value="DHQS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001381">
        <property type="entry name" value="DHquinase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023193">
        <property type="entry name" value="EPSP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008289">
        <property type="entry name" value="Pentafunct_AroM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041121">
        <property type="entry name" value="SDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010110">
        <property type="entry name" value="Shikimate_DH_AroM-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01357">
        <property type="entry name" value="aroB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01093">
        <property type="entry name" value="aroD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01809">
        <property type="entry name" value="Shik-DH-AROM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090">
        <property type="entry name" value="AROM/DEHYDROQUINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090:SF5">
        <property type="entry name" value="PENTAFUNCTIONAL AROM POLYPEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01761">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24621">
        <property type="entry name" value="DHQS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01487">
        <property type="entry name" value="DHquinase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18317">
        <property type="entry name" value="SDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000514">
        <property type="entry name" value="Pentafunct_AroM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="EPT/RTPC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01028">
        <property type="entry name" value="DEHYDROQUINASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00104">
        <property type="entry name" value="EPSP_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 14" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 14" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="3-dehydroquinate synthase N-terminal" evidence="16">
        <location>
            <begin position="91"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="3-dehydroquinate synthase C-terminal" evidence="19">
        <location>
            <begin position="204"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Enolpyruvate transferase" evidence="15">
        <location>
            <begin position="423"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="Shikimate dehydrogenase substrate binding N-terminal" evidence="17">
        <location>
            <begin position="1277"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="domain" description="SDH C-terminal" evidence="18">
        <location>
            <begin position="1526"/>
            <end position="1556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR000514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF18317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF24621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EMF14621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1559" mass="169671" checksum="3469B64FF6865EB1" modified="2013-05-01" version="1">MASNKAPSAGSETATKVSILGKDTIIVDYGLWPHYATHDLLANIPSSTYVLICDSNLAKLPYVPAFIRSFEAERAKLGKRAEDVRLLVYDTIPPGETSKSRKVKAQIEDWLLSQGCTRDTILLALGGGVMGDLLGYVAATYMRGIKFVQIPTSLLSMVDSSIGGKTAIDVPMGKNLVGAFWQPERIYIDLAFLETLDKRQVCNGMAEVVKTAAIWDEREFERLEEGADAIMAALERPLGRGRFEGIENVFKRIVLGSARVKAEVVTADEREGGLRNLLNFGHSIGHAYEAILTPEILHGECVAVGMVKEAELARYLGILEPAAVARLTKAIKSYGLPTSLEDKFITKKTRKVCKADELLRKMAVDKKNAGSKKKIALLESIGKCYEPETGPGAAKCDDEDIRIVLCPSVLVKPGVPEGLDVVCKPPGSKSISNRILLMAALGKGECRITNLLASDDTQYMLSAIASLRGATYAWEDSGRVLVVNGNGGNLKASADEIFIGNAGTASRFLTTALTLAEPSKEASHTILTGNARMQERPQGPLVDALKSNGVDMEYLGKPGSQSLPLRIGAAGGFEGGDIELTAKVSSQYVSSILISAPYAKKPVTLRLVGGKVISQLFKKSMIALMSRPQFFPTESIPVIILEHLRNRHAFLFLKFKVHVDEWPTQNSCSPASSRGLTSTSHANDEDRLLDFSIHITIDFSDAVGVAVRVTISVRLLRLDTLEFDAKSLVQDVPPARPSLASTLSLENQRALRCNSSKDTETHRHSVVIVAIYGARGRLNVTTNAINLNTVIQLSARHTKLCKLIDHRYNAVALFNFLVCNADDSCCRAIFVRFRNSSEDRCSQESISHGLHVQLGYGLELADRRSCDCCARLRLLHRTSHGAEYINSEARIALQGRRPDVWHRALCPGNGRNSEGVSRATRITFNLVFSWVDVALLGNVVNVLLPIMAIVISMYIDKTRPAYVEDMMGVYLRRKPWFEECSNLHYHSQTVDETTAIVGWTSPLDDFTRFLNTMTGRSGALQKILAKQHSFFIALTSPTIQQIVPILPEVTMGSDAIELRVDLLVDPDKEPGETHWRPGFLSEQVALLRASTTLPLIFTLRSVSQGGQFPDEATEQAIALYAEGLRMGFDFVDLELTAAPELKEYVLSHRKMCTIISSHHDPKGQLSWADGAEEWRAHFDAARQYGDIVKLIGVAKDSDANDDLKAFKKTVAKEFPHLPVIAMNMGELGKMSRVTNGFMTPVSHPALPVKAAPGQVSAAEIRKVLGIVGEIPAKKFYLFGKPVQQSRSPALHNTLFNLTGLPHIYGTHETDQASSAADIIRSPEFGGASVTIPLKLDIMPLLDAIDPAAQTIGAVNTIVPTKSSSGKNMLVGHNTDWQGMVLALRNAGAQSTPAAVSREAGMVVGGGGTARAAIYALKNMGYSPIYLLGRNKTKLAQLTASFPAEYNITLLSSPEEARQVAVPPVVAVGTIPGDLPIDTTLESILQTVFAQSAATTRSKVLLEMAYKPAVTQLMELAEKSGWNTVPGLEALVAQGVHQFKLWTDIMPLYEVSRNAVLGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2022-12-14" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>M3C5P2</accession>
    <name>M3C5P2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_114679</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763712.1">
        <property type="nucleotide sequence ID" value="XM_016901105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C5P2"/>
    <dbReference type="GeneID" id="27898242"/>
    <dbReference type="HOGENOM" id="CLU_2293461_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF15591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="101" mass="10995" checksum="98795488C00016CB" modified="2013-05-01" version="1">MTGRRFERSGSSTAAIFTKDEDIPYLEPRDIDDIDALTCMEDAGWIGRDALKYELGNQSTRGTSDYRCPLYISNAISLVRASGSYRGTSVPGGPIKEGLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M3C7X5</accession>
    <name>M3C7X5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">DNA polymerase</fullName>
            <ecNumber evidence="20">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">SEPMUDRAFT_167090</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27 28">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 20">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="19">Forms DNA polymerase zeta with REV7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 20">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="20"/>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF07990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756111.1">
        <property type="nucleotide sequence ID" value="XM_016908277.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.M3C7X5"/>
    <dbReference type="GeneID" id="27905414"/>
    <dbReference type="eggNOG" id="KOG0968">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000203_3_1_1"/>
    <dbReference type="OMA" id="GRNKMGF"/>
    <dbReference type="OrthoDB" id="2414538at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016035">
        <property type="term" value="C:zeta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05778">
        <property type="entry name" value="DNA_polB_zeta_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05534">
        <property type="entry name" value="POLBc_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000007">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.342.10:FF:000018">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.690:FF:000002">
        <property type="entry name" value="DNA polymerase zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000024">
        <property type="entry name" value="DNA polymerase zeta catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056435">
        <property type="entry name" value="DPOD/Z_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030559">
        <property type="entry name" value="PolZ_Rev3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056447">
        <property type="entry name" value="REV3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025687">
        <property type="entry name" value="Znf-C4pol"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45812">
        <property type="entry name" value="DNA POLYMERASE ZETA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45812:SF1">
        <property type="entry name" value="DNA POLYMERASE ZETA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24055">
        <property type="entry name" value="POL3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24065">
        <property type="entry name" value="REV3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14260">
        <property type="entry name" value="zf-C4pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 20" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 20" id="KW-0235">DNA replication</keyword>
    <keyword evidence="15 20" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12 20" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="13 20" id="KW-0408">Iron</keyword>
    <keyword evidence="14 20" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 20" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17 20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="11 20" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 20" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase zeta catalytic subunit N-terminal" evidence="26">
        <location>
            <begin position="27"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase delta/zeta catalytic subunit N-terminal" evidence="25">
        <location>
            <begin position="86"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="23">
        <location>
            <begin position="849"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="22">
        <location>
            <begin position="1094"/>
            <end position="1540"/>
        </location>
    </feature>
    <feature type="domain" description="C4-type zinc-finger of DNA polymerase delta" evidence="24">
        <location>
            <begin position="1600"/>
            <end position="1689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="314"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="364"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="505"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="579"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="791"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="505"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="527"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="582"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="617"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="21">
        <location>
            <begin position="828"/>
            <end position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00066055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF14260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF24055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF24065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="EMF07990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1725" mass="195266" checksum="44758051E6070B96" modified="2013-05-01" version="1">MAMGGGSHPFVLGFPVGTSGLHRHDVFRIRLNCIDFAQYAPNTLDPPIWGPRSLSATQRVQLPDVPVIRVWGSTETGQKACVHVHGAFPYLYVPYVDSIEESQVAHYISNLRSSIDHALCLSYRRNPYDNPRNATFVAHISLVKGVPFFGYNVGYKYYLKIYLLNPLHMTRFADLLHQGAILRQHFQPYEAHLQYQLQWMCDFNLYGCAYIEVSKPHFRAPIPRWEEMDDLAHLWHDRSIDSQHVLDADQFPRQSHCQLEVDIRVQDILNRNAIQARPLHHSFIERMASLENLPPEEKLVHSMAGLWKDETRRRKRRMGISDPSSSPFPPEVLVSMSADPRNDSTGGWVHEDEFRDAIAELAEQEKKQRGGAPLSFESFGSQKHDHDDGVQTVLESVSELFHTTLEQKWDKLAPATEAREQQPHELSFEEFVGTQRRPDHAPVVDESSIALMGEDEGYLSDEDAAKELALTQKQKLEDAGLEEAMGEANVNESVGAALPQTIVEGTQQPNSLKRSAPSGSQLPFKKARMDAPDHSSRWKHMYRPSRAKDIGTSSRPGGDGFAAPPAAQARNGVFVNERLTDAPPSAQPPLSQRSLQSSHGDKIAFPSVKNAHESNSGRRLSQRASQLSQKDALVSSTASSFSNKSLQSPEDPRQLLHPTTALAYADGFGIDPSRRVLMLRTLPPTQNEVATTVNPSVIYQDAYYSNEKDVPERVREYAGQEFRLESNTLPFLPPFDSGGVVGQAGRQSKADAEFALNRRRWQCSLKSWELMKPPPSRSEVERWLRMEEPSKPDDLNILDLDGPPSPSQLKRKNKPPPELSQIEGPTQRNKHGFKYSQRKASTSVQHETGYMSTMSLEVHVNSRADLAPDPERDEVNMVVWCITDEQMDDSPKLGILVLIEEDEELPAKIRKMVGDHVQIDSEDNELDLINRMVDIVREYDIDILTGYEVHNNSWGYLIERARLHYEFNLPDEFSRMKSHSKGRFGRDADRWGFTHTSTVSITGRHTINIWRAMRSELNLLQYTMENVVFHLLHRRIPHYTYATLTRWYKSDRPRDLAKVLDYLVTRTKLDLEILDANELIPRTSEQARLLGVDFFSVFSRGSQFKVESLMFRIAKPESFVLVSPSRKQVGSQNALECLPLVMEPQSAFYSSPLLVLDFQSLYPSVMIAYNYCYSTCLGRVTKWRGTNKMGFADFKRHPGLLELTKDKLNVAPNGMMYVKPELRKSLLAKMLGEILETRVMVKSGMKVDRDDKTLQQLLNNRQLALKLIANVTYGYTSASYSGRMPCSEIADSIVQTGRETLEKAIALIHSVERWGAEVVYGDTDSLFVYLKGRTKDDAFRIGDEIAKAVTDTNPRPIKLKFEKVYHPCVLLAKKRYVGFKYESPSQKEPDFDAKGIETVRRDGTPAEQKIEEKALKLLFRTSDLSQVKAYFQSQCTKILTGRFSVQDFCFAKEVKLGTYADRGPPPPGALIATRRMLKDPRQEPQYGERIPYVVVAGAPGARLWERCVEPEQLIRDENAELDAEYYINKNLIPPLERIFNLVGANVRSWWDELPKVQRIRQLSSVTHQQDHHHNNPPAFTRGNAKISRKTMESYMATSSCLVCHTKLSTAAPPKSASSSSSAPQPISLPLCPTCRYSHPTSTLLHLRRKFQSAEFQVSSLYDVCRSCAGLAFDEEIFCESRDCEVFYSRVKAETRLRGARRGVGRVLEVLEGEVAGGGGGKGLEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M3C9K5</accession>
    <name>M3C9K5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Prion-inhibition and propagation HeLo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_53657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756631.1">
        <property type="nucleotide sequence ID" value="XM_016909269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C9K5"/>
    <dbReference type="STRING" id="692275.M3C9K5"/>
    <dbReference type="GeneID" id="27906406"/>
    <dbReference type="eggNOG" id="ENOG502SMTD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1013919_0_0_1"/>
    <dbReference type="OMA" id="DIRIFGW"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1020">
        <property type="entry name" value="Prion-inhibition and propagation, HeLo domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029498">
        <property type="entry name" value="HeLo_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038305">
        <property type="entry name" value="HeLo_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14479">
        <property type="entry name" value="HeLo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prion-inhibition and propagation HeLo" evidence="1">
        <location>
            <begin position="25"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF08510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="291" mass="33028" checksum="FDA8872C818EDA5C" modified="2013-05-01" version="1" fragment="single">MSANDKINSDHVEQLECPQNEAYLAGAIALASLFSSCVEAFGLIHPSQQWNKAEQLLLTRLGLQQARLLIWGSVVGIASPPAQVTTKAVPKNPSMAYPDLAEPTFFDARDPRLDEPDLRTTIEQTLSAIVDRSSSSTREEMMAKFGLKPPKKIGPILEQAMDTTRLESFREKHELLKEVAEDVAQLNTRRNQSLVYTSWMIADIHKFGNFIDLTQEKVDYLINLLDVKDKVDRAMRMDIRIFGWHVIPDRARTALDISKLRMLQEICSKDYPEYLVAIQQALDNISRETRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M3CAT6</accession>
    <name>M3CAT6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Nucleolar essential protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_128501</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757046.1">
        <property type="nucleotide sequence ID" value="XM_016902217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CAT6"/>
    <dbReference type="STRING" id="692275.M3CAT6"/>
    <dbReference type="GeneID" id="27899354"/>
    <dbReference type="eggNOG" id="KOG3073">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055846_1_1_1"/>
    <dbReference type="OMA" id="VHNTFEL"/>
    <dbReference type="OrthoDB" id="269804at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005880">
        <property type="term" value="C:nuclear microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070037">
        <property type="term" value="F:rRNA (pseudouridine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18088">
        <property type="entry name" value="Nep1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1280.10:FF:000003">
        <property type="entry name" value="Ribosomal RNA small subunit methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005304">
        <property type="entry name" value="Rbsml_bgen_MeTrfase_EMG1/NEP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636">
        <property type="entry name" value="NEP1/MRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636:SF5">
        <property type="entry name" value="RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE NEP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03587">
        <property type="entry name" value="EMG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF08925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="256" mass="28191" checksum="997486FD4446391D" modified="2013-05-01" version="1">MANQMPTPTGPQTQSLPPPALPRLVAEQAHPIPSSDKDTKRLIVVLSNASLETYKAAHGGRNGTKDDKYSLLNSDEHIGIMRKMNRDISDARPDITHQCLLTLLDSPVNKAGKLQIYIHTAKGVLIEVSPTVRIPRTFKRFAGLMVQLLHKLSIRSTTSQEKLLKVIKNPITDHLPPNCRKVTLSFDAEVVRVRDYIGGLAPNESICIFIGAMAKGNDTFADEYKDDSISISNYSLSASVACSKFCHAAEDCWDII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M3CCT8</accession>
    <name>M3CCT8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sphingolipid C(9)-methyltransferase</fullName>
            <ecNumber evidence="14">2.1.1.317</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SEPMUDRAFT_71430</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">SO2202</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CFA/CMAS family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.317" evidence="14"/>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758348.1">
        <property type="nucleotide sequence ID" value="XM_016909938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CCT8"/>
    <dbReference type="STRING" id="692275.M3CCT8"/>
    <dbReference type="GeneID" id="27907075"/>
    <dbReference type="eggNOG" id="ENOG502QS47">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026434_5_0_1"/>
    <dbReference type="OMA" id="GFKTWLF"/>
    <dbReference type="OrthoDB" id="412182at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052290">
        <property type="entry name" value="Sphingo_C9-MT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45197:SF1">
        <property type="entry name" value="SPHINGOLIPID C9-METHYLTRANSFERASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45197">
        <property type="entry name" value="SYNTHASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02353">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMF10227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="524" mass="59365" checksum="AE6BB31DF38DE7C2" modified="2013-05-01" version="1">MASRQAINDLPASQQPGHSQAEDEFEFIHTPKAPTPVPEAQNYGVRTTAYPAIKNAPLPADGPGSETFNNAFLFTLLAGIPAYFAYQVNGGLITWVFFAILTAIPILMAFWTIASAMSPRLNEKAKLPGAPIEQYLTFKSQEDKRKYRGKNKIPMETFHEMYFDEKVDFNGDCLEIMEYRHDWANFRFTLSLFWFFLTGMMPEVIMHTRSQDEEQVRDHYDRGDDFYGWFLGPRMIYTSGIISDINKEESLEQLQDNKLGLVCEKIGLKQGEKMLDIGCGWGTLAKFASANYGANVTGITLGRNQTAWGNNGMRKLGIPEEQSRILCMDYRDIPVPEGGYDKITCLEMAEHVGVRYFGSFLSQVYNMLDDDGVFFLQIAGLRKAWQYEDLIWGLFMNKYIFPGADASTPLGFVVDKLEGAGFEVKGIDTVGVHYSATLWRWYRNWIGNKDKVVGKYGVRWYRIWEYFLAYSTIISRQGSATCFQITLVKNINSTHRIEGIPNAFGLHGAINACKEAGKSTFPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M3CD30</accession>
    <name>M3CD30_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aspartyl aminopeptidase</fullName>
            <ecNumber evidence="4">3.4.11.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_151294</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal aspartate or glutamate from a peptide, with a preference for aspartate.</text>
            <dbReference type="EC" id="3.4.11.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the peptidase M18 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.21" evidence="4"/>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758438.1">
        <property type="nucleotide sequence ID" value="XM_016906725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CD30"/>
    <dbReference type="STRING" id="692275.M3CD30"/>
    <dbReference type="GeneID" id="27903862"/>
    <dbReference type="eggNOG" id="KOG2596">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019532_2_0_1"/>
    <dbReference type="OMA" id="GPILKVN"/>
    <dbReference type="OrthoDB" id="9880441at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05658">
        <property type="entry name" value="M18_DAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.250.10:FF:000001">
        <property type="entry name" value="Aspartyl aminopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.250.10">
        <property type="entry name" value="Aminopeptidase i, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001948">
        <property type="entry name" value="Peptidase_M18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023358">
        <property type="entry name" value="Peptidase_M18_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002759">
        <property type="entry name" value="PRK02813.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570:SF3">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02127">
        <property type="entry name" value="Peptidase_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00932">
        <property type="entry name" value="AMINO1PTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101821">
        <property type="entry name" value="Aminopeptidase/glucanase lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11 13" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 11" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF10317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="518" mass="56606" checksum="7B14E51684731438" modified="2013-05-01" version="1">MASKSTISRPADFVDFLHASPTPFHAVQSSVQRLEKAGFKQIRERDPWSSTLTPGGKYYLTRNTSTVVAFAIGSEWKPGNPIAMVGAHTDSCCLRLKPVSKRSAEGFLQVGVETYGGGLWHTWFDRDLGIAGRVMVKKGEQVEQKLVRIDKPIARIPNLAMHFGGSEPFTFNKETQLFPVLGLISAELNRVGKTKEEAKEEEETEKKEAGEGEFEPLKTVTKRHHPYLIELIAKDAGVEAADILDFELVFYDVQPPCLGGINDEFIFSARLDNLGMTYCAVEGLIKSVESPSALQGDSTIRLIACFDHEEIGSKSAQGADSNMLPAVIRRLSVLPSAAKDDSEKSYDKVSAGESVDTSTAYEQTLATSFLISADMAHSINPNYGGNYEAEHRPHMNEGTVIKINANVRYATNSPGIVLLQECARRAKPSSYQAPGIKKSETGVPLQLFVVRNDSRCGSTIGPMLSAALGARTIDVGNPQLSMHSIRETGGAYDAEYGVNLFDSFFEHFGELEGKIMVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M3CDW1</accession>
    <name>M3CDW1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_134402</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759332.1">
        <property type="nucleotide sequence ID" value="XM_016902641.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.M3CDW1"/>
    <dbReference type="GeneID" id="27899778"/>
    <dbReference type="eggNOG" id="ENOG502SHDW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000739_1_1_1"/>
    <dbReference type="OMA" id="QIVMKDT"/>
    <dbReference type="OrthoDB" id="2546325at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF9">
        <property type="entry name" value="NACHT DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G01760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="331"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2082"/>
            <end position="2189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2121"/>
            <end position="2132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2162"/>
            <end position="2173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF11211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="2189" mass="245394" checksum="0872AEF74AC24D1D" modified="2013-05-01" version="1">MQRPTSMVAPSTPQKNNISTNFNGTNGMTDSGYSSPISPSLHNGGSNRGSTRMSASYSAFRSSFGGGQQKSSIVQDTAYTLKRKSASELGAGISETADNVSFINLVEWIRSERLQTLPHKGSRWDTVLIRALYFAERLHGFEVGLKAHALETEHAAQLGYGHIRLLLELGHSNSLALDSAFGFIYRCSSAVSVLLARSEVLKLSGDVYQQLCFMYTDLLALVVDVAVRFYRTVHGSAGQSASLDMYEVFGETITTFRQRREAITKAIWKEQIEADGTLDDSVDVDHLSRWLAPQDRVLATLAQDHTLIANDMAEFTGVWFLDDLSAFVKSNDSTLLVNGPPGSGKTTLSAALAERLQRPVARKGYTTAFCSVGAVPSQATSLSVVKALLHQIYTIRVGNVGLYQAVVTAYERARYTADPSKYEDLLWEALENALRSPLQNAPSLVLIVEGIDEIIGGQSAGQALLQRLVHAVEQGHGVQLIAMAQDLKLPTGARGTSRGITETDTKGDIHEVVIKTLIKSAHFRGKTGREQESVAEYVIAAADGNFLWAELTSEVLRLEKSPQDLDNAVKDLSKSKKSIDELTLLLLTRLQPSEDAKLLLSFLVNAARPLTWDEIESLYTINVQTANRSERRVDVHSIVATLAPLLDIQEDIIRPRHASVQTATRNLFQSGKITIPVKDQKLDLLLRILAYTKMSLTEKGEPTLDDTDRTVVEHNFSRYPLLEYVIRYYPWHLQQSGVITQGKPTEPKISPELQKMFPESTVMAVLEWLVWDDQFPGAQEVEVHDMVRRVRTKILTEKHPAVLQSYINTACYWEVLEDWTKAGELYYPICTIGRTILSVLHPVVVESAVRYIRITDSYTSSTRTDIITRREQTFILLISAYERQFGMSSEVVIRTRERLVELYIAIGEEEHARDILKIIHGHSSDSNGTTGGSTRAVDERFVVKFGKQKHGQELGEYDSGIFIDDEKDEDALVVIDVGQADVILREIDEMIARQEFVRAEQTYVELWQRLSETCRTSLAVEWHEKKIQVVQAYSRYLQTQKRTTEATSLTMSIWREYEHHELSYSEKIVKRLTESAAFLKSVGEYSAALSIHKHASYYYKNVRQEESKSLTEIEEEMTVISNLALTKATQDTKSTSSSSSNEQYDMFRVLISNKSKSVEASTLSLAKTLTQRYIEEKQYTQAISVIQVTLDRTWSSFLSKSLHEVTIASSFQKESIELVERLAEVYILQRRFEKAEDIYVRLFRAALTSPKDTALLDRAKTLIINFYQDRGHPSKIIAVYQELLAVYRRTLGPSHEITITTLYELGSRCRKHARSHPYWIEYYQQIVTVLNKDSTTVHVRAMDATIIVAESYWEERRYSDAVAAYAIIWNTFVQKHKEFQLFSDANFVSSIYERYYQSLEETKADYEVLLQVTKQYRETTKAVFGATSTIAVQATVALARVTEQSESRMEESIALYEEASKSASQSDSSSSSSNFDSSELRQSLTGLYKKRIFQSSSSANSDTISKAVSVYQDQFSDYKNKYTYSHQETLNSLRELSLLYVRQQKTDLAAKELNTALITIAQQETSSERMYESAVSLVQTYRAANLIQQCTQIVEEMHYQLVVREKRSSSSFSVVEASHAALFFLATLEYQLRQDVAITLSEIMASLSAEAFMYGNFKQLVKNNAPLDRLLLAAAPLRYLLLRANRTGLIAAVDHECVHIFEQREASNVQLLSKESPRYFIVGILEHIANRKCNDFVRAVILASNGTLKKLVDTNKFADAHDIAKMTFMYAQHRKGYRGPKGISRGFELASYLDGRGENRCPDPELRKKLLQLSNKIVKDIIAICREENINFAQVPLKELNELIALLGEQQDYDTLEMLLTELWTTREAQKKWAPEVLLLLGRRLICARYLAGRQIKALRLAEDIAYNLRRVNGIKSSATLEAYGLLAELYTSIGGNYQKEAGAGDKSAAGLAADHFRKAVVIHEDILRWLRSDATGGDVDDGVDIDDDDSAAQILAEHGIHHDTHGQHQDVEGTGFSTAQRGQLIKWHLRLLKLAYQRYGSWPKDYKHYESLNAQLFRTFATELKGVEGVEKWQAKGFGAGKAESNEGAFQGNQPEPKPKHQNPTITMSGLLNKAKEAMGKSSGGSTDAATGGAGGTQSGIEKGISGAGHTQIDNATDRLGMGDKYDDKINKLADGQINKNVPGGATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M3CE41</accession>
    <name>M3CE41_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7924 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_150266</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759427.1">
        <property type="nucleotide sequence ID" value="XM_016906058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CE41"/>
    <dbReference type="STRING" id="692275.M3CE41"/>
    <dbReference type="GeneID" id="27903195"/>
    <dbReference type="eggNOG" id="ENOG502SK65">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025457_2_0_1"/>
    <dbReference type="OMA" id="NEGWENS"/>
    <dbReference type="OrthoDB" id="5132737at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057684">
        <property type="entry name" value="DUF7924"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42470:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42470">
        <property type="entry name" value="VAST DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25545">
        <property type="entry name" value="DUF7924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7924" evidence="2">
        <location>
            <begin position="206"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="464"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="464"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF11306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="510" mass="58038" checksum="972FAEFCF6579835" modified="2013-05-01" version="1">MACNRPNTGPRSAGVKRRWSVGSERSRKSARLEEIRQNSSQTAHTPQEALPRKRTRTDASPQDDQVEQLRKRAKIECAEEISTGEEDLDPIAYWSQHHRWPDKYLEACDPMANILARKRSTSSRSRKTSWVDLVTASSITPSDQKPREEKSADYKTVRYETVLATKGIFMERSKLGVAESSRTLCQDLLANDQTLPKESLFDDDLFEETCRMVRGRNEAKIIQDITRLVVPSAQVLAMRSGGQLTGLIESVNEGWNNCISITKTRPQPDYAVGFRREAFTQTQLDRMQPVVGDLMDQSYFMATYYMYFPFLTCEVKCGDTGFDIADRQNAHSMTIAVRAVVELFRAVKREKELHREILAFSISHDNENVRIYGHYAEVDEREPKYYRHPIRQFNFTELDGREKWTAYKFTKSIYNSWMPVHFQRICSAIDDIPADVSFALSGSDLHFTEQSGLSQDVSAHSIASSSVDSRSVQAQDTHSSAVDNPSGTPSTSLDGGVFKKPRRDRDRGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M3CG06</accession>
    <name>M3CG06_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_141608</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760859.1">
        <property type="nucleotide sequence ID" value="XM_016902971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CG06"/>
    <dbReference type="STRING" id="692275.M3CG06"/>
    <dbReference type="GeneID" id="27900108"/>
    <dbReference type="eggNOG" id="KOG1231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018354_1_2_1"/>
    <dbReference type="OMA" id="KPACMFF"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF13">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032706" evidence="5">
        <location>
            <begin position="23"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="46"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF12738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="501" mass="54963" checksum="78284EC2F97AEC9A" modified="2013-05-01" version="1">MSRTFAPRWAVLLLSAASLCLADPNADTTAACRALTLTDYWSLANADNKPACMFFPKTAEEIQFAVVTLNKYPTAPWGIKGGGHNPNVGYSSSRDGVLIATHPYMATTTLDENNYARVGPGCKWIDVAEALDPHNRAVVSGRLGVVGAAGLTLGGGLSFLSTEYGMTADNVVEYQVVTATGELTRANRDQNSDLFYALKGGGNQFAIVTEFVMNTYPIGDVWGGVKIYTMDQKEALLQATHNLVSDYYDPKAAVIVTYTSTVESLIEVFVVFYFYNSPSGPGKILEEFNSIPALISRTKTRSYLDLLDSNSIFSIPGMRYLIRTGTLPNLPGPRGLDLYTYTFDSYFNGSRSAQFSELDNYAFSLSFQPIPTTLANASLNNPHGVNLLGLDPAHGDKVFMEYNVSWLLSSTDEDAAAVLTNLTEPAQVYARGMYPNVAPTHYVEGDLETVGYRPLFMNDAMFNQNPLRSYGEETFARLKEIQKLRDPEGFLARRQGGFKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M3CGX9</accession>
    <name>M3CGX9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Superoxide dismutase [Cu-Zn]</fullName>
            <ecNumber evidence="3 10">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_148452</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="10">Binds 1 copper ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="3 10"/>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761199.1">
        <property type="nucleotide sequence ID" value="XM_016904938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CGX9"/>
    <dbReference type="STRING" id="692275.M3CGX9"/>
    <dbReference type="GeneID" id="27902075"/>
    <dbReference type="eggNOG" id="KOG0441">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056632_4_1_1"/>
    <dbReference type="OMA" id="AQRGFHI"/>
    <dbReference type="OrthoDB" id="2015551at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902693">
        <property type="term" value="C:superoxide dismutase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016670">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901856">
        <property type="term" value="P:negative regulation of cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00305">
        <property type="entry name" value="Cu-Zn_Superoxide_Dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.200:FF:000001">
        <property type="entry name" value="Superoxide dismutase [Cu-Zn]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018152">
        <property type="entry name" value="SOD_Cu/Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="SUPEROXIDE DISMUTASE CU-ZN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00068">
        <property type="entry name" value="CUZNDISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00087">
        <property type="entry name" value="SOD_CU_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00332">
        <property type="entry name" value="SOD_CU_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="9 10" id="KW-0186">Copper</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Superoxide dismutase copper/zinc binding" evidence="11">
        <location>
            <begin position="14"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF13078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="154" mass="15823" checksum="D1E0D245735AB537" modified="2013-05-01" version="1">MVKAVAVLRGDSNVKGTVTFTQDSETSPTTIEWDITGNDANAERGMHVHAFGDNTNGCTSAGPHFNPHSKEHGAPEDTERHVGDLGNFKTDGQGNGKGSVQDKLIKLIGPESVLGRTVVVHAGTDDLGKGGHAESKKTGNAGGRPACGVIGIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M3CH51</accession>
    <name>M3CH51_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_63781</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761259.1">
        <property type="nucleotide sequence ID" value="XM_016909652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CH51"/>
    <dbReference type="GeneID" id="27906789"/>
    <dbReference type="eggNOG" id="ENOG502TE27">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063098_0_0_1"/>
    <dbReference type="OMA" id="RSSRWHY"/>
    <dbReference type="OrthoDB" id="3786918at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF1">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF13138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="325" mass="38421" checksum="C59D765D37EA30A8" modified="2013-05-01" version="1">MSCDEQMMEPASNASVLQQPHILHLPAEIRVNILEYVFSSSSSSFSSSAGLKTSSTGEILLDEHYRASQHLQPLLVCRQFYREASLFAFSHTPFLISNLFTSIPQRLQQQQQQQQQQQQQQQQQQQPPLLHPQQTASIRSLAFVADKRHFRNLIDWHDGHPWGIPSLALESLTIILHRSSAWHYMFDFTSSLVSLLRRLRGVRKIKFVQNAALVKGSFRTWYNRLVGLMLKIDHRERYERFPARGEVTWWVWRFDEVGRTFTLEARPAKEMGVEEERYMLQMLPLVEELRRDVEREEWNPGIIFFFFFFFFFFIMRVLEECWGAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M3CHP2</accession>
    <name>M3CHP2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_148654</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat MET30/SCONB/SCON-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761429.1">
        <property type="nucleotide sequence ID" value="XM_016905060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CHP2"/>
    <dbReference type="STRING" id="692275.M3CHP2"/>
    <dbReference type="GeneID" id="27902197"/>
    <dbReference type="eggNOG" id="KOG0274">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_103_1_1"/>
    <dbReference type="OMA" id="GIAHVWS"/>
    <dbReference type="OrthoDB" id="5580488at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043224">
        <property type="term" value="C:nuclear SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140299">
        <property type="term" value="F:molecular sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990756">
        <property type="term" value="F:ubiquitin-like ligase-substrate adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046685">
        <property type="term" value="P:response to arsenic-containing substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046686">
        <property type="term" value="P:response to cadmium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd22147">
        <property type="entry name" value="F-box_SpPof1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.50:FF:000016">
        <property type="entry name" value="E3 ubiquitin ligase complex SCF subunit sconB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000715">
        <property type="entry name" value="F-box protein MET30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051075">
        <property type="entry name" value="SCF_subunit_WD-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19872">
        <property type="entry name" value="UBIQUITIN LIGASE SPECIFICITY FACTOR/HREP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19872:SF9">
        <property type="entry name" value="UBIQUITIN-BINDING SDF UBIQUITIN LIGASE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="8">
        <location>
            <begin position="169"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="359"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="399"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="439"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="478"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="591"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="650"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="55"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="8"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF13308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="735" mass="82954" checksum="54C49F0669ABEAF8" modified="2013-05-01" version="1">MAESVVMAEERHECDHGHGHGHHDHESSRKLQHPPNKHADMNLSTFLHEHIPASYNPPIADSSASHSHKDHHHHHEHDAEEQRPNTKFCYRHHPDIKCRRQANETSMEQLQDELSGLPQMDQQVISQVWSSFSAAPAKHRKLMLQGILTQCCFPQLSFISANIRDLIKIDFLSALPAELGFKILCYLDTTSLCKAAQVSQRWRTLADDDVVWHKMCEQHIDRKCNKCGWGLPLLERKRLRIEKRQIQLRATGRGLNQWSPNITPIPEDFESLTMGPPEMLDGEASSSRGLKRSREGAASISPELAKRHCSISSQESVPVGVEGNDAYFAPRKRPWKDVYKDRFKVSTAWKNGRCTTKVFKGHTNGVMCLQFEDNVLITGSYDTTVKIWDIDTGEVIRTLTGHTAGIRALQFSGDRLVTGSLDSTVKIWNWREGKLLKTWQAHDAGVITVNFTQRYQASGSQDKNIRVWDLTTGQTFLLRGHQDWVNSVKIDDASRTLFSASDDLTVRIWDLDSRQCIREFTGHVGQVQQVVPMPPEFNLDDIVLTPNDKDDDTSSISSVTIAPSHREHNHHNLDAAPQFWPHDEDRAAPPRYMITGALDSTIRLWDTHFKTAGFGQEGTSDCGQVGSSILPTDPLTNSHFPRAQACIRTFFGHVEGIWALSADHLRLISGSEDKMMKVWDPRTGKCDRTFTGHQGPITCSWLSDSRVASGSEDCEVRMLCFGDERRAANGVAEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M3CNE0</accession>
    <name>M3CNE0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Heme oxygenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_147224</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763424.1">
        <property type="nucleotide sequence ID" value="XM_016904156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CNE0"/>
    <dbReference type="STRING" id="692275.M3CNE0"/>
    <dbReference type="GeneID" id="27901293"/>
    <dbReference type="eggNOG" id="KOG4480">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038284_1_0_1"/>
    <dbReference type="OMA" id="CELITLQ"/>
    <dbReference type="OrthoDB" id="652091at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004392">
        <property type="term" value="F:heme oxygenase (decyclizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006788">
        <property type="term" value="P:heme oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19165">
        <property type="entry name" value="HemeO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002051">
        <property type="entry name" value="Haem_Oase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016053">
        <property type="entry name" value="Haem_Oase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10720">
        <property type="entry name" value="HEME OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10720:SF0">
        <property type="entry name" value="HEME OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01126">
        <property type="entry name" value="Heme_oxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF15303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="246" mass="28093" checksum="4F64029261C49B28" modified="2013-05-01" version="1">MQRLPLALPPNQQGPLLFARGIVPFARIFFFFESEWDLLIRHAASPSDGVQKWLADLRPHGLARATRLENDLKHLRAVAGPNIYRTPDLGDYWLRDMRTRLRSQPHVLMAYAWVFYMATFAGGRWIRQQLANGGAEFWTQRPLTDVDVVEEGPAPEFHGFSFLSFDGDQDGEDIKALFKTRLAEAETLLTGEQKQDIVDVAQQLFERCNKLVGELDVMVTRDRVPTWLLPTCFVLFLMLLFVCGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M3CP27</accession>
    <name>M3CP27_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Replication factor A protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_60476</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the replication factor A protein 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763654.1">
        <property type="nucleotide sequence ID" value="XM_016909527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CP27"/>
    <dbReference type="STRING" id="692275.M3CP27"/>
    <dbReference type="GeneID" id="27906664"/>
    <dbReference type="eggNOG" id="ENOG502SBIR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141922_2_0_1"/>
    <dbReference type="OMA" id="HRYKEIF"/>
    <dbReference type="OrthoDB" id="188186at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04479">
        <property type="entry name" value="RPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000271">
        <property type="entry name" value="Similar to ssDNA binding protein Ssb3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013970">
        <property type="entry name" value="Rfa2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15114:SF1">
        <property type="entry name" value="REPLICATION PROTEIN A 14 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15114">
        <property type="entry name" value="REPLICATION PROTEIN A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08661">
        <property type="entry name" value="Rep_fac-A_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF15533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="109" mass="12347" checksum="29D21AEF59650949" modified="2013-05-01" version="1">MSEATPRITAPYLEQFSHRTVRILGKVRQIRGETATIEAGGQVQLHLNKDCHLQNNHAFEFIGKVQQDLSVRVLASTDFGPEGNIDFNAIEAVVDATHRYHEIFYPKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M3CUN7</accession>
    <name>M3CUN7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_121777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456310">
        <property type="protein sequence ID" value="EMF07877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016755998.1">
        <property type="nucleotide sequence ID" value="XM_016901727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CUN7"/>
    <dbReference type="GeneID" id="27898864"/>
    <dbReference type="HOGENOM" id="CLU_089044_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF07877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="194" mass="22052" checksum="CB684CC836E8AC2D" modified="2013-05-01" version="1">MASAMSIAQKRKQSIARKTPRTGAKGLPSRTGSKKLPGTRIKKGYRYAPGNNEQDDDEQDEDKQEQDKQDQDVRDQDVQGRDFQASYNQEELDDDSSDNEQTLKQRLEAYANELVAAAHALTIAKERSEDGLRLAQETLEGDAKKIARQFHRWQRLNFEDQLCAYQKIQDAEVEALKQQAKEQAALDAQLLTKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M3CWR7</accession>
    <name>M3CWR7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GRF-like zinc ribbon domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_9919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756683.1">
        <property type="nucleotide sequence ID" value="XM_016910657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CWR7"/>
    <dbReference type="GeneID" id="27907794"/>
    <dbReference type="eggNOG" id="ENOG502SYG5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_146190_0_0_1"/>
    <dbReference type="OMA" id="APRIWCG"/>
    <dbReference type="OrthoDB" id="4469945at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056444">
        <property type="entry name" value="Zn_ribbon_GRF_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23549">
        <property type="entry name" value="Zn_ribbon_GRF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRF-like zinc ribbon" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF08562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="101" mass="11628" checksum="D200188ABBC3397B" modified="2013-05-01" version="1" fragment="single">PRCSSCDATYPYLRRFVTRRSNRNGNAGRPYLKCMPCEKFITFLDDRGINFDGPHCLCDFPCRLQVSGRYVVTTTPRGLHYVCAFGRCKYHEPVKRDGKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-05-03" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M3CWT3</accession>
    <name>M3CWT3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_112166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF08136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756257.1">
        <property type="nucleotide sequence ID" value="XM_016900958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CWT3"/>
    <dbReference type="GeneID" id="27898095"/>
    <dbReference type="HOGENOM" id="CLU_1422236_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032901" evidence="1">
        <location>
            <begin position="31"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF08136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="191" mass="21556" checksum="FEEE6152376B99F0" modified="2013-05-01" version="1">MPTSFSTLTLTTTTMLLFILTSGIIQPTHATVSNCYTQSNVTVICEFPDNAVDPDCKVSNLACPPTECLVGYTREEWFCDRWQGWGCSYAVGKVGKTNRIDEYDYEYSQLVFLIRIDLVLTLSTLPNRWRSTEREREITYSTNLPIDASEDRPTALTNPTVTRRLELRIKTAIIEISSSVDFCLSMGTLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M3CYU1</accession>
    <name>M3CYU1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_158077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF09824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757945.1">
        <property type="nucleotide sequence ID" value="XM_016907766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CYU1"/>
    <dbReference type="GeneID" id="27904903"/>
    <dbReference type="eggNOG" id="ENOG502RGTX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1001734_0_0_1"/>
    <dbReference type="OrthoDB" id="3626988at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="278" mass="31339" checksum="077209565298A562" modified="2013-05-01" version="1">MVLRSAWFRGSQGMEGIQMEVKKLDQQSLLFLERECLTSLCKRAKKKRNREAVHKWRENGSKSIVLDVLTTLQYVALRPPCPLAPYNMQILDSFSPTKLTQSFNQPPAAYPSQSRTTNTLTMSNMPTTLLDLSDELLAHICSYAMISLAADDNNNNNNNNDDNNTSSSPQTSNPTTPSNPRPKFPTPINGVITEQISKRLRHLLQPFRCCHRLYKIAKYQFLESNVIVLNLSDIRGSASRLEFTSGTTQMIMTGNPDPLLRNLVHVQLVGEEEEEVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M3D076</accession>
    <name>M3D076_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_151268</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758405.1">
        <property type="nucleotide sequence ID" value="XM_016906707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D076"/>
    <dbReference type="STRING" id="692275.M3D076"/>
    <dbReference type="GeneID" id="27903844"/>
    <dbReference type="eggNOG" id="KOG0180">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_10_0_1"/>
    <dbReference type="OMA" id="CSEQLYG"/>
    <dbReference type="OrthoDB" id="204949at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061133">
        <property type="term" value="F:endopeptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03759">
        <property type="entry name" value="proteasome_beta_type_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000003">
        <property type="entry name" value="Proteasome subunit beta type-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033811">
        <property type="entry name" value="Proteasome_beta_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF10">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF10284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="206" mass="22477" checksum="9ACAFEB40F62E6AF" modified="2013-05-01" version="1">MSSPFSINGGACVAMVGKDCVAIACDLRLGLQALTVSNNFPKIFPFGSSTYLGLTGLATDVSTVSELFRYKVNMYRLREERDISPRTFANLVSSSLYEKRFGPWFISPVVAGLDSKTGKPFICGFDSIGCIDFAKDFIVAGTASDQLFGTCEGLWEPDLGPEDLFETMSQALLSAVDRDALSGWGAHVYIIEKDKVTKRLLKGRQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M3D0B2</accession>
    <name>M3D0B2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_144033</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758440.1">
        <property type="nucleotide sequence ID" value="XM_016903062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D0B2"/>
    <dbReference type="GeneID" id="27900199"/>
    <dbReference type="eggNOG" id="ENOG502R9K9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013600_0_0_1"/>
    <dbReference type="OMA" id="MGWWPEE"/>
    <dbReference type="OrthoDB" id="4814197at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.490">
        <property type="entry name" value="GxGYxYP glycoside hydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025832">
        <property type="entry name" value="GxGYxYP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038410">
        <property type="entry name" value="GxGYxYP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032626">
        <property type="entry name" value="GxGYxYP_N_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048310">
        <property type="entry name" value="GxGYxYP_N_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048309">
        <property type="entry name" value="GxGYxYP_N_3rd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37321:SF1">
        <property type="entry name" value="EXPORTED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37321">
        <property type="entry name" value="EXPORTED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14323">
        <property type="entry name" value="GxGYxYP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16216">
        <property type="entry name" value="GxGYxYP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20957">
        <property type="entry name" value="GxGYxYP_N_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20958">
        <property type="entry name" value="GxGYxYP_N_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GxGYxYP putative glycoside hydrolase first N-terminal" evidence="2">
        <location>
            <begin position="37"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="GxGYxYP putative glycoside hydrolase second N-terminal" evidence="3">
        <location>
            <begin position="110"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="GxGYxYP putative glycoside hydrolase third N-terminal" evidence="4">
        <location>
            <begin position="340"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="GxGYxYP putative glycoside hydrolase C-terminal" evidence="1">
        <location>
            <begin position="446"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF10319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="682" mass="75119" checksum="5714930CF0514700" modified="2013-05-01" version="1">MLVYIPDDAVFGSTALNWPADSALPHFPDIGDAIDAADITALTGEERVLLTTLQGIVNRQQPRIYLHWNKTDEANDGSNQAWLRDIAEYVHVDDCSGHPFGILERYRSEIAGAIVYDPDVVDTVNLATTVAGLRGAVVATAELAYQHQLPILEDFRGRFDNKYDVYNYALEHIYPLLTKRAITALTPEETRTIPSVPWSNLTSEKNRTVDASNNATYTVDLTPFLVQLQEDGTVYVRIKDAFEDDGHGAAVSHVLALADEEVLADFTPGTAGEDPFLVDWGGSYLHDYPWGWRSADGGAHIVYGFRPPNGTRSLTVNLTMANQFDVAATTTLPAVKVLNAVFRDYITAIAAPCIWLDPNNPDELPLLNRILESFDANSAYLGWFPNGDEMSGVTRTAANSMFVVAADYFFNGSFMSGLRSLFSTTTQNRKLPPPPAIEITKSSIPNKIYLSLTWTEGDNIQYMQHRMRVIWDDPARGQIPMGWTVSPILQDIAPNMLHYFQSSATSNDTFVTGPDGVGYTFPSNWPESDFELFLDMTARYTKSIGTASNIWVYNRINATLYPLANETIEAYHRALGPDLLGISADGHASGYGINVTSSDSGSVPVAGLATISSVKQGMERLQNISTQMYDGTKPVFVVCALYAWDTTPGNITQLVGQLGEEFEILGPEEHFRLFMEAQGIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M3D2H2</accession>
    <name>M3D2H2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7871 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_109427</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759463.1">
        <property type="nucleotide sequence ID" value="XM_016900782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D2H2"/>
    <dbReference type="GeneID" id="27897919"/>
    <dbReference type="eggNOG" id="ENOG502SCEH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133919_0_0_1"/>
    <dbReference type="OMA" id="CTCEKAT"/>
    <dbReference type="OrthoDB" id="4140664at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057193">
        <property type="entry name" value="DUF7871"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40620">
        <property type="entry name" value="RESISTANCE PROTEIN CRD2, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04318)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40620:SF1">
        <property type="entry name" value="RESISTANCE PROTEIN CRD2, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04318)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25277">
        <property type="entry name" value="DUF7871"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7871" evidence="2">
        <location>
            <begin position="8"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF11342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="111" mass="11280" checksum="52A097497A5BE00C" modified="2013-05-01" version="1">MSAPTAAVPATCCGREGGCVCAKEAMCSCGKQSALHCNCEKAATENKVEGARCSCNQRPAGACTCSRSSTENAKVMGSACACGKRAKDSCTCGGTESGTSEMETDFTTRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M3D2R2</accession>
    <name>M3D2R2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DAGKc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_150371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759553.1">
        <property type="nucleotide sequence ID" value="XM_016906124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D2R2"/>
    <dbReference type="STRING" id="692275.M3D2R2"/>
    <dbReference type="GeneID" id="27903261"/>
    <dbReference type="eggNOG" id="ENOG502S2DU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021934_0_0_1"/>
    <dbReference type="OMA" id="YGFHASI"/>
    <dbReference type="OrthoDB" id="3853857at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001727">
        <property type="term" value="F:lipid kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF108">
        <property type="entry name" value="DAGKC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAGKc" evidence="1">
        <location>
            <begin position="76"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF11432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="430" mass="46743" checksum="A0986154B0BC3551" modified="2013-05-01" version="1">MIPAKNILVCAPTQGGEEGDHHCLYVEENQDAAQDSSASPVLFRKVILNNPPDSLIKEFIAPASGANWETRQDRGGVQANFHIIVSTGSGTGLALGVWNQLVKPALDYIKVQESKDYVLHITTSENSISDLTRDILLPQANLGISQSVMLMSGDGGVVDIVNTLLSGQRGHKYKKPNIALLPLGTGNALAHSAGLTQDNSLGLRTWLRGGLKELPLFCAKFSSGARSLFDEARQERPLHVENDVAVAYGSVVASWGLHAGLVADSDTTEFRKFGVERFKMAAQQALAPSDGSLPHVYKAKVSIQRPGDRSWHVLRNGEHAYVLATLCNQLEKSFTISPASSALDGKLRLVHFGPMSGDEAMSIMGKAYQGGLHVNDERVGYEEIEALRIEFQEEEGRWRRVCIDGKIIRVEKDGWVEVRSGQAGVVDLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M3D2Z7</accession>
    <name>M3D2Z7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EI24-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_149224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760721.1">
        <property type="nucleotide sequence ID" value="XM_016905426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D2Z7"/>
    <dbReference type="STRING" id="692275.M3D2Z7"/>
    <dbReference type="GeneID" id="27902563"/>
    <dbReference type="eggNOG" id="ENOG502SH72">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062645_0_1_1"/>
    <dbReference type="OMA" id="REFWPLF"/>
    <dbReference type="OrthoDB" id="2107885at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005619">
        <property type="term" value="C:ascospore wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005628">
        <property type="term" value="C:prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052786">
        <property type="entry name" value="Spore_wall_assembly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN LDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292:SF1">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN RRT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF12600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="32698" checksum="5C9A7F30CC2B176D" modified="2013-05-01" version="1">MATASASRTEPLRHFVRANFSPAFLYPLKGIWYFATHRYLHTLLQSRLIPLTLLSTCVLAILFLTAYLPLVAFLALFHTRGSAWVNATFFLLGVGAVIIQLLFEGMLVDHTQVDVYDAVLVGEGYEHLVKNRRTVSDDINESDPYKRLGTRDKGAAFSPFSVRQIIELLFLLPLNLVPFAGVPLFLVLTGYRAGPLLNWRYFQLKRFDSKQRKQFIKTKARRWEYMWYGTVHITLQLIPVLAMLFLLTTAAGSALWSVQLEQRLQQSQLVQQSEEDDEPPAYTDEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M3D4Q1</accession>
    <name>M3D4Q1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DAO-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_148569</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761316.1">
        <property type="nucleotide sequence ID" value="XM_016905006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D4Q1"/>
    <dbReference type="STRING" id="692275.M3D4Q1"/>
    <dbReference type="GeneID" id="27902143"/>
    <dbReference type="eggNOG" id="KOG3923">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034311_3_1_1"/>
    <dbReference type="OMA" id="EDLWWAP"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006181">
        <property type="entry name" value="D-amino_acid_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF11">
        <property type="entry name" value="D-ASPARTATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00677">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="34"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF13195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="282" mass="30649" checksum="769A944EED50D402" modified="2013-05-01" version="1">MQDSLHYWDGPIEEDLWWASHVEDYRSMALSEEPVRTINATRPPHAPEIKFAAYSRAHSLDAPGHLLYLRNRARKSGVIIFQSTLPTDGGLSKALHTAEGLSQAIDRGRVNVFINCTGLGARQLCNDDAMYPIRGQTVLVKGEAQATRTRYHAGTIGKGDTSYCIPRPGTGTTILGGTKEVGQSSPEPDETVTKKILDRCSWMVPELLTAEDGGFEVVSVQCGLRPARHGGPRVEREVVEGMRVVHAYGHAGGGYQNSVGCARKVVKLVEESLGLATSKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>M3D4X8</accession>
    <name>M3D4X8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_148617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761381.1">
        <property type="nucleotide sequence ID" value="XM_016905034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D4X8"/>
    <dbReference type="GeneID" id="27902171"/>
    <dbReference type="HOGENOM" id="CLU_2814055_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF13260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="67" mass="7560" checksum="3B6CEDC1C635AE1C" modified="2013-05-01" version="1">MKASSSSQETRYRPHHLRQRSGVGSERDQGKLMQSCSLHMRQACGRAKRLVVALLCFRNSDTCHALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M3D635</accession>
    <name>M3D635_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Allergen Cla h 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_141035</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WrbA family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761756.1">
        <property type="nucleotide sequence ID" value="XM_016902951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D635"/>
    <dbReference type="STRING" id="692275.M3D635"/>
    <dbReference type="GeneID" id="27900088"/>
    <dbReference type="eggNOG" id="KOG3135">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051402_0_1_1"/>
    <dbReference type="OMA" id="KFADGNP"/>
    <dbReference type="OrthoDB" id="504689at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000001">
        <property type="entry name" value="NAD(P)H dehydrogenase (Quinone) FQR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010089">
        <property type="entry name" value="Flavoprotein_WrbA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01755">
        <property type="entry name" value="flav_wrbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002999">
        <property type="entry name" value="PRK03767.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546">
        <property type="entry name" value="FLAVODOXIN-RELATED PROTEIN WRBA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546:SF23">
        <property type="entry name" value="FLAVOPROTEIN-LIKE PROTEIN YCP4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="4">
        <location>
            <begin position="5"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF13635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="208" mass="22232" checksum="4690217601A072DD" modified="2013-05-01" version="1">MAPKIAILFYSMYGHVATLAEAEAEGIRAAGGQVDIYQVPETLPQEVLTKMHAPGQGTKYPVIDHPKTLEQYDAFLFGIPTRYGNFPAQWKAFWDSTGGQWQTGAFWGKYAGLFVSTGTMGGGQESTCIAAMSTLAHHGFIYVPLGYKTTFALLGDLSEVRGGSAWGAGTFSAGDGSRQPSKKELELATAQGKAFYEAVKKVDFAGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M3D6P8</accession>
    <name>M3D6P8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_85068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761961.1">
        <property type="nucleotide sequence ID" value="XM_016910376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D6P8"/>
    <dbReference type="GeneID" id="27907513"/>
    <dbReference type="eggNOG" id="ENOG502SR2P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_497478_0_0_1"/>
    <dbReference type="OMA" id="KPSHEVW"/>
    <dbReference type="OrthoDB" id="5430532at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="385"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF13840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="548" mass="58983" checksum="A0C5E2CB718DED87" modified="2013-05-01" version="1" fragment="single">MASRMKRKFSFDIPKLKIGNLGTIGNIGHLGSSSRPDPRAWKDHYASPPESRPSTPKSVRPPMPSDIEAELRAACSYIITHPKPSHEVWGEEAAKPALDYAAIKAGGVADAAPVAVLPTRTRSARQRPEQSREPPLSSRYAYKPHVATEDLFNGEGNGIVLPAITARSRADVLMAGEPVKSASSQHRPRAESIGAIQPPVAVARHENSERTRTSQRSDSVGTSGSTPHTDSTDYPWSASTGLTSAVNTPARSKRTSGQAVTSTSDNGSMPKVDAVNADWMRTELEKHKKAIGEKERQKAVDPASHSGTMASPTSYSHVPARKPVPSQPASRKASNAISPPSIQDIQPESTDQPDRGRTLAARADSSQPETEGDARGRMIVRSRSRLSMASRAASRAASRAANEAKSITQDILGHYLRPNSDQDAREPVERPPSRARDIAFGVKDYFRPGTATGFRSGKISGEFTRGHARKQSTSSVQTTNSEVAPSEGSANWKKWRPRNKSHANAVSPELSRPDSAASRPVIDLNRELPPLPGLDSWKDEEPAPAPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M3D6Q5</accession>
    <name>M3D6Q5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_85075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761966.1">
        <property type="nucleotide sequence ID" value="XM_016910377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D6Q5"/>
    <dbReference type="STRING" id="692275.M3D6Q5"/>
    <dbReference type="GeneID" id="27907514"/>
    <dbReference type="eggNOG" id="ENOG502S8B6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027006_1_0_1"/>
    <dbReference type="OMA" id="GVFAAPW"/>
    <dbReference type="OrthoDB" id="411251at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="494"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF13845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="521" mass="56925" checksum="A4A46DEF0A618A28" modified="2013-05-01" version="1">MDTTFISIHDLTDNATILYSSDSVVDVLGYTPDEIVNHSAWDLFPEEELAAARKFHRRRVNTDKAAVLAYVRIRNREGNWVGCEVCMTVVYDVIVVCTSVYRKGLKSEKRALEAPAVRRIFSSSPKDPRYHMLSHLSTKFSQPVKQQQHEPRAALFLNRFTRTLTIMYATSGLNEVIGIPAETMRGRSFYYCIAENCLQDAVKCLETAKGNDSIAYLRFWFRDPRIDDQPTDDESSDEDMTTDTSEDGGVVLAGGESTVAHGIAMDMDSDESHKDSRHSSGDSTQTTEAHETTFGHARRAESSTSSLGHSPTGDVTSPPPQVPEPIELEAVISCTSDGLVVCLRKARPMIPQPNQRPLQPHQNGLFAAPWGHQPILPPVEARAGHDYGDRYAPAAGPQGARRDDPVVPAGPEHMDFMTAIREQAVFAWALTGINGMLADYGHGTPTGESLPQDGLPVWASDPKSKLREDTMDSAYSSGAGRPSHVFGDPGLDRNSTNGSRLGSGSNTSSSGNTPFQPPPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M3D8Q6</accession>
    <name>M3D8Q6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pseudouridine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_124666</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762636.1">
        <property type="nucleotide sequence ID" value="XM_016901930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D8Q6"/>
    <dbReference type="STRING" id="692275.M3D8Q6"/>
    <dbReference type="GeneID" id="27899067"/>
    <dbReference type="eggNOG" id="KOG2554">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014673_2_3_1"/>
    <dbReference type="OMA" id="SCRERRY"/>
    <dbReference type="OrthoDB" id="25767at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00171">
        <property type="entry name" value="TruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF5">
        <property type="entry name" value="TRNA PSEUDOURIDINE(38_39) SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="5">
        <location>
            <begin position="272"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF14515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="546" mass="61146" checksum="9DCB8A540335D3DE" modified="2013-05-01" version="1">MDTDYASWSNADLVQRVSELEAQLRTQNANHAVNGSSAPLKRKPRKEPKKFDASRYHTRLIALKFAYLGANYNGFEHHANNTTPLPTIEEELWRAMRKVKLIFPEQKPGQSEEDVCWDGIEYSKCGRTDRGVSAFGQVIGVRVRSARIKEKKQVLPNEVSAGAESQGADTIMPDVSQDANAAAAPPAEKEFDPIRDELPYIQLINRVLPPDIRILAWCPEPGDGFSARFNCKERRYRYFFTNPAYAPLPGGKPWENGKPGEGFLDIEAMNVAAKKYEGLHDFRNLCKVDPSKQITNWERRIFHAGIHEVGPHSSAAVSNGDTPKLYYFEVRGSAFLWHQVRHLVAILFLVGQGHEQPSVVDDLLNVQKTPGKPHYEMASDVPLVLWDCIFPSVEELSTSDHAGNDQSMAGGYHDAMRWIYIGDEDGGREQNKRSSTGVEDGKHGRNGIMDDLWGLWRKRKMDEVLAWNLMGVVSAQGQQPLSDQIPPPSAERSARVFDGSAVPRTVGTYTPIAQREQMETPDVVNARYAARKGLVAKPLRDEDADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M3D9L8</accession>
    <name>M3D9L8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_148241</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762690.1">
        <property type="nucleotide sequence ID" value="XM_016904795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D9L8"/>
    <dbReference type="STRING" id="692275.M3D9L8"/>
    <dbReference type="GeneID" id="27901932"/>
    <dbReference type="eggNOG" id="ENOG502S2DX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_287602_0_0_1"/>
    <dbReference type="OMA" id="DPHETAV"/>
    <dbReference type="OrthoDB" id="4115400at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="63"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="134"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="247"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="470"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="622"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="859"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="913"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="774"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="261"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="470"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="653"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="689"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="705"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
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            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="985"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="995"/>
            <end position="1019"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF14569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1071" mass="118447" checksum="01B6499275FE91BA" modified="2013-05-01" version="1">MPGPARLPTGATTATLSRLRIKQDAARARNSRSNTEMTKAYESFGNLSIFFGTPDSKQKCRAILQQQPRPAPYNDDDDGESESGHSSGEDESNVGNRADLDDAEGPNERGTYSKEYTLKHPETKWVHRGQGRYLPASKVKAEPPAQQALRPTRKLPERATTTSSAITAETMEGMLQELWHDFNEHRIKLNPNARPGWSPQLRGQWNGITALLKESPRQDWLQAIEGIEHPEYREIVRNWISAMDRTFPSSAPDSVGRTRPTRQARSSVGNASSNRRRSTRLVDATVNTYGESDEELEEEDLEEESEVEDEGEITSHIRTSPHNHEGHVSNNPRSTRCGSSTSHANKCSSSEASHDMNGDTAVKKEDLHKHTGRIVHHRGNQFYRPGPSPHGIKGTKLVLADGELLGLHELSTKDAEDLLAKAEKNNFGLDDPRGALQTAHYNNGRRKSSLHSMATETLVPAAWSSGRRVSKADPTKIDTDDVARGHSGRRLSIKSSVEAKDALMRDNKLKTTRTKSDPDVLLDKDYVDARPDEIFHHRGQGKWARGLPPPGSSNKMAVRGPNAKELFDAMQRGEEIDENGKIPPPITALLRREEGPDLYPQYQWHYRGGGKHCRLTKEEAENYEASLRPAKKQRTSAGSRPRGDGPEAQLHRASASAADAGSSNVLSGVKRKASTLLQRSTKVIRKRSQQTGLHSKASSNAEPKAPTPRPPPLAPEDDRLTDADLPSLYKDDWSDVDEQDDEAEHILRQIFRPIVGPDPFVAALTKFDPAARSMESLKGLAANAQTALKQLQDEYLELDQIVARNPMHGKKERKPMHGGREPVSHDVWEDKKEAALYDYAFDARKIGFQDPDAQRIVRDAEGRELRRRRGRNDPHTSQVNYGDGEMTTRRTVKPVSRFDGVVVPVLRQKSRLSVADSTEVDDNNNNKTESTTPDRTRTPVLEGDPHEWVPPSRGRWAGHIPKRIQELRGASVSRRSESGSPQPPGAASSSSSSVRKGRPPGSKNHHERKDKGIKKGPRKKKDDNASSPAAGSDVNDAAQGDGASEAEKEERTRGGRAVNPMSLDAIVGPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M3DAI8</accession>
    <name>M3DAI8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Eukaryotic translation initiation factor 2 subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_147074</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF2B.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763231.1">
        <property type="nucleotide sequence ID" value="XM_016904068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DAI8"/>
    <dbReference type="STRING" id="692275.M3DAI8"/>
    <dbReference type="GeneID" id="27901205"/>
    <dbReference type="eggNOG" id="KOG2916">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033458_0_1_1"/>
    <dbReference type="OMA" id="DVNEHQR"/>
    <dbReference type="OrthoDB" id="1685042at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043614">
        <property type="term" value="C:multi-eIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990856">
        <property type="term" value="F:methionyl-initiator methionine tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04452">
        <property type="entry name" value="S1_IF2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1130:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000015">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.190:FF:000002">
        <property type="entry name" value="Translation initiation factor 2, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1130">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.190">
        <property type="entry name" value="Translation initiation factor 2, subunit 1, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044126">
        <property type="entry name" value="S1_IF2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024055">
        <property type="entry name" value="TIF2_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024054">
        <property type="entry name" value="TIF2_asu_middle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011488">
        <property type="entry name" value="TIF_2_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07541">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110993">
        <property type="entry name" value="eIF-2-alpha, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116742">
        <property type="entry name" value="eIF2alpha middle domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="17"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="275"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="294"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF15110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="312" mass="35006" checksum="3D6EBF7AFAABAEB9" modified="2013-05-01" version="1">MSLTNCRFYEEKFPEIDSFVMVNVKQIAEMGAYVKLLEYDNIDGMILLSELSRRRIRSIQKLIRVGRNEVVVVLRVDKDKGYIDLSKRRVSPEDIVKCEERYNKGKMVHSIMRHVAEKINVPIEELYQDIGWPLNKKYGHAVDAFKLSITNPDVWNEVTFKSSAIKDELVSYIGKRLTPQPTKVRADIEVTCFGYEGIDAVKTALRAAEAKNTPETQVKVRLVSPPMYVLTSQTIDKNNGIDVLTEAIQDVAAKITAAGGSCTIKMAPKAVTENDDAELQALMDKKEREQQEVSGDEDSSESDDGIVAANAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M3DC79</accession>
    <name>M3DC79_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">O-acetylhomoserine aminocarboxypropyltransferase</fullName>
            <ecNumber evidence="12">2.5.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SEPMUDRAFT_147308</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-acetyl-L-homoserine + hydrogen sulfide = L-homocysteine + acetate</text>
            <dbReference type="Rhea" id="RHEA:27822"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57716"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="2.5.1.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-acetyl-L-homoserine + methanethiol = L-methionine + acetate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10048"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16007"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57716"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="EC" id="2.5.1.49"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homocysteine from O-acetyl-L-homoserine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.49" evidence="12"/>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763535.1">
        <property type="nucleotide sequence ID" value="XM_016904217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DC79"/>
    <dbReference type="STRING" id="692275.M3DC79"/>
    <dbReference type="GeneID" id="27901354"/>
    <dbReference type="eggNOG" id="KOG0053">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018986_4_0_1"/>
    <dbReference type="OMA" id="NAFQIIQ"/>
    <dbReference type="OrthoDB" id="3512640at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003961">
        <property type="term" value="F:O-acetylhomoserine aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071269">
        <property type="term" value="P:L-homocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000083">
        <property type="entry name" value="O-acetylhomoserine sulfhydrylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000035">
        <property type="entry name" value="O-succinylhomoserine sulfhydrylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006235">
        <property type="entry name" value="OAc-hSer/O-AcSer_sulfhydrylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01326">
        <property type="entry name" value="OAH_OAS_sulfhy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43797">
        <property type="entry name" value="HOMOCYSTEINE/CYSTEINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43797:SF2">
        <property type="entry name" value="HOMOCYSTEINE_CYSTEINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="7 13 14" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="434"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="438"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="13">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMF15414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="458" mass="49013" checksum="69AD43671A5B9BB4" modified="2013-05-01" version="1">MAAQDHQPRFETLQLHAGQEVDPHTRSRAVPIYATTSYVFNDSAHGARLFGLKEFGNIYSRIMNPTVDVLEKRVAALEGGVAAVATASGQAAQFMTIAALATAGDNIISTSNLYGGTYNQFKVAFPRFGITTKFVNGDKASDFAALIDDKTKAIYIETIGNPRYNVPDFEAIVKVAHAAGVPVVVDNTFGAGGYFARPIDHGADIVVHSATKWIGGHGTTIGGMVVDAGKFDWGTPAARKRFPQMSEPSDGYHGLKFWDTFGAITFIIRLRVEILRDLGAALNPFAAQQLLIGLETLSLRCERHAQNALQLATWLENNPNVAWVSYPGLTSHPSHELAKKYLPRGFGGVLSFGVTGGGTAGSQVVDGFKLISNLANVGDSKTLAIHPWTTTHEQLSDEEKIGSGVTEDLIRISVGTEHIDDIIADFEQSFAQAATKPGQGTDNSQVNGDAKGQGKTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M3DCA5</accession>
    <name>M3DCA5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">YWTD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_147323</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763560.1">
        <property type="nucleotide sequence ID" value="XM_016904229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DCA5"/>
    <dbReference type="STRING" id="692275.M3DCA5"/>
    <dbReference type="GeneID" id="27901366"/>
    <dbReference type="eggNOG" id="KOG2304">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072072_0_0_1"/>
    <dbReference type="OMA" id="GMKVMRC"/>
    <dbReference type="OrthoDB" id="5958943at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050778">
        <property type="entry name" value="Cueball_EGF_LRP_Nidogen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46513:SF13">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46513">
        <property type="entry name" value="VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF15439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="326" mass="36279" checksum="EBD22D77E9B0EA83" modified="2013-05-01" version="1">MPSADKVTVLYVLDVKDAKDDDKLDVSGRVAVGSVVKGGLQTLIEHQERPDGIEVISEGDGHLIWTQMGIPNKNDGHIQCSDLDGKNIRDVYAPGEIHTPKQCSVDVINHKFYVCDREGMRVHRSNLDGSEKEVLIRRGDYNNPEHVSDKTRHCVGICVDQKRGKFYWTQKGTSKGGKGFIYRANITMPPGKNADTRDDIETLFRNLPEPIDLEINPETQTLYWTDRGAEPKGNTLNKADISGDFSSSTENRDYQVLGEHLHEAIGLKVDEVNKHIYVSDLGGSIYRYGLEGGKPENLFEGEGVYTGLALARLEKSRAKAMFGFDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>M3DDE0</accession>
    <name>M3DDE0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Elongation factor 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SEPMUDRAFT_147611</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763960.1">
        <property type="nucleotide sequence ID" value="XM_016904413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DDE0"/>
    <dbReference type="STRING" id="692275.M3DDE0"/>
    <dbReference type="GeneID" id="27901550"/>
    <dbReference type="eggNOG" id="KOG0062">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1242">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002848_0_0_1"/>
    <dbReference type="OMA" id="VLSEAMW"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18626">
        <property type="entry name" value="CD_eEF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000076">
        <property type="entry name" value="Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.990:FF:000001">
        <property type="entry name" value="Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000193">
        <property type="entry name" value="Probable Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015688">
        <property type="entry name" value="eEF3_ABC2_chromodomain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047038">
        <property type="entry name" value="eEF3_chromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040533">
        <property type="entry name" value="EF3_4HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047036">
        <property type="entry name" value="EF3_4HB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF5">
        <property type="entry name" value="ELONGATION FACTOR 3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17947">
        <property type="entry name" value="4HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 16" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <feature type="repeat" description="HEAT" evidence="13">
        <location>
            <begin position="99"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="13">
        <location>
            <begin position="179"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="437"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="680"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="988"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1014"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1033"/>
            <end position="1044"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMF15839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1056" mass="117621" checksum="186B01B772ACB8F5" modified="2013-05-01" version="1">MSQAAKENAGSAQVLEQLLTKLSVSKTADEAKGASQEIATFINGDIQEADAPTKAVDSLKKMLNNKKDAGARQNACEAIATIAKHSDVSVTVEPYLVQLLPAVLAAVGDKMAAVKVAAQDAAISITKAVNANAVKLLIPHFVNSIRTAQKWPEKMTDLECIEALTESASAQAAYRVPDLIPIVSEAMWDTKPEVKKKAYSTMEKVCALIVNKDIERFIPELIKCISKPENVPETIHLLGATTFVTDVHEPTLAIMVPLLERGLKERETAIKRKSAVIIDNMCKLVEDPNIVASFLPKLMPQLNHNNENLADPEAREKTKQALDTLIRVGAVKDGKIPEVAHDSDVETVLAKLKDILSYKHKDTVEKFATIVEYIAAIGGQLIDEKEVEAVSWTTHLLPYVSAVVGDDAASIVDQLRKRSLPGALAEDEVEPDEEEGVDLCNCTFNLAYGAKILLNQTHLRLKKGQRYGLLGPNGSGKTTLMRAINNEQVEGFPKQSEVKTVYVEHDLDSDDTEMTTIEWTLKKLAEANIKIPEDQVRKTLDDFGFVPEQVNGVITALSGGWKMKLALARAVFSEPDILLLDEPTNHLDVKNVKWLEDYLTSSPCTSIIISHDSKFLDNVVQHVIHYERFKLKRYRGKLSEFVKRVPSAKSYYELGASEMEFKFPEPGFLEGVKTKAKAIVRVSNMSFQYEGTPKPQIQDVTFQCSLGSRIAVIGPNGAGKSTLVNVLTGELIPTKGDVYQHENIRIAYIKQHAFAHIDHHLDKTPSEYIQWRFQTGEDRETMDRANKIVTEDDEKAMDRIYRIEGSQRRVIGVHSRRKFKNSYEYECSFALGDNIGMKNEKWTPMMTADNAWIPRNELIQSHQKMVADVDQKEALASGQFRPLVRKEIEAHCTNFGLDAELVSHSRMRGLSGGQRVKVVLAACSWQRPHLIVLDEPTNYLDRDSLGALSKAIKSFEGGVIIITHSAEFTKDLTEEVWAVMDGRMTPSGHNWVQGQGAGPRLTQGDDEEEKFDAMGNKIENTKKAKKLTASELRKKKKDRMARRKKGEEVFSDEDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M3DE33</accession>
    <name>M3DE33_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PRTase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_147713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF16015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764136.1">
        <property type="nucleotide sequence ID" value="XM_016904476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DE33"/>
    <dbReference type="STRING" id="692275.M3DE33"/>
    <dbReference type="GeneID" id="27901613"/>
    <dbReference type="eggNOG" id="KOG4203">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067096_3_0_1"/>
    <dbReference type="OMA" id="SENSRIW"/>
    <dbReference type="OrthoDB" id="10257085at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF16015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="136" mass="14750" checksum="085D6B57206E6EBF" modified="2013-05-01" version="1">MVEAVQNLLPHPVSVHHLGMYREKSTMQPVEYYNNLPYHKSGEASTVPPLAIIVDPIIATGSTVCAAIETLKDWGVQRIISISILASQSGLQRAAEAWPEGVELWVGGVDAETDERGMIKPGLGDIGDRLYLTLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M3DED8</accession>
    <name>M3DED8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tafazzin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SEPMUDRAFT_147803</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a cardiolipin + a 1-acyl-sn-glycero-3-phosphocholine</text>
            <dbReference type="Rhea" id="RHEA:33731"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="ChEBI" id="CHEBI:62237"/>
            <dbReference type="ChEBI" id="CHEBI:64743"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:33732"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:33733"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion outer membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the taffazin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF16165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764286.1">
        <property type="nucleotide sequence ID" value="XM_016904534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DED8"/>
    <dbReference type="STRING" id="692275.M3DED8"/>
    <dbReference type="GeneID" id="27901671"/>
    <dbReference type="eggNOG" id="KOG2847">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046747_1_0_1"/>
    <dbReference type="OMA" id="IMRYFKW"/>
    <dbReference type="OrthoDB" id="193467at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047184">
        <property type="term" value="F:1-acylglycerophosphocholine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035965">
        <property type="term" value="P:cardiolipin acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000872">
        <property type="entry name" value="Tafazzin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12497:SF0">
        <property type="entry name" value="TAFAZZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12497">
        <property type="entry name" value="TAZ PROTEIN TAFAZZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00979">
        <property type="entry name" value="TAFAZZIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="14">
        <location>
            <begin position="64"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="371"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMF16165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="395" mass="45350" checksum="42E573B8DA78540A" modified="2013-05-01" version="1">MAEDERPYQPSLPWRITSAATLGTVGFLCRSFLYTLSRTEVHGLDQFLQVLDEREDEQGRTRGLVTVSNHVSILDDPLMWGALPHRYFWKPNNMRWSMGSYDICFQNSIVSAFFSFGNTLPTHRSAHSKFGGLFQPTMTECIRLLSDPHGSRSPSASSSKEDIHFSSLPASDPFSSAQLTYTTNGYDTFPAPSAYPLRRHTWVHIFPEGMIHQHPSRVMRYFKWGIARLILESEPCPDVIPIWIDGPQHVMDNERTWPRFLPRVGKDVTIAFGERVNRELLLEPFRERWRELKERVKRKAVHEGSNLKGLPLETLGVVADDELRYGREAQQLRIEVTLALRDEVLKLRRQFGLPDEDPKRSLADCYREEGELGRDGFGDIHGVKKLHDGSTTKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1QD59</accession>
    <name>N1QD59_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_151297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757291.1">
        <property type="nucleotide sequence ID" value="XM_016906728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QD59"/>
    <dbReference type="STRING" id="692275.N1QD59"/>
    <dbReference type="GeneID" id="27903865"/>
    <dbReference type="eggNOG" id="ENOG502SDIM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_341359_0_0_1"/>
    <dbReference type="OMA" id="HRCGCRA"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="545"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="724"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="771"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="728"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="831" mass="92515" checksum="A45D493321A293E1" modified="2013-06-26" version="1">MHRLLSRAAQVRSRSSKRSRSSCHCAPCLPTLPGTVARGHGAGVLRPPYRTRSTPRFTSIFATAATTATTYDARIRGQRRQQWNQAMDGVKQELGRGDAAADGDDNATPVEIYDDFNADVERNLDSSLYRLFRPAWPSNTGPALNRYHLPPQSIYARDLSKMKAETTRWTQKKILRVELCMDILQLQCFQWLHSIGFLGNESALSSLPPSYVNTIVQHPAHVCKRSLLQKKADYIHLMRTPSDESGGIAFQRSPEDVPICKYTQDELGAFRSEQLELRRRLEQLFAAKYQADQEPQLICNAFHLLAASSAPPNVDIYNTLMNGLRKRGHVFLTTATIQTFFGSKMRANEVSLAVMLGFYTDTNNAEQFRMLIQKMRGQSGGLMKSKPGNWRFKASKGRIIPDPRNPSILIQLPHPTPMVFDAVVKGVLHFSGFDAALGMCRNLRDEGWGMDMRGFGILLNDCARRGDWNVGYPVWNQIVKLKQRSARLVDGHLQTEIIMTPIFADMLRLCRRCDKKHEFGDVWDLAKKTHPITINRIMEMVKAERSARTDTRPPELAESLTQSEPRGGESTRAALAAEDSAEARVQALQALAELRAKGANTVGESNLQQEYLALKADVDFLRTMEGGNGAEQSKTRSWAELARDAYNLIASHPTTLERRTFGQSNAQSRLADDVGRPVTYSELAKNAYYLVADHPSTMEKRGGDESSKFIDNVDLDISQGEIPGLEADSEHANSRGDSARPLVKSDEGPTTPVTYTSLAQSAYRLIADPATSLQRRGHQNPKSGHIPDGDTDAHSTSSLHGHDDTSTPGPAESASFNDDQEPPSVRKRERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDM4</accession>
    <name>N1QDM4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Box C/D snoRNA protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Zinc finger HIT domain-containing protein 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SEPMUDRAFT_151549</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with FBL, SNU13, NOP58, NUFIP1, RUVBL1, RUVBL2 and TAF9. Interacts (via HIT-type zinc finger) with the RUVBL1/RUVBL2 complex in the presence of ADP.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the BCD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757701.1">
        <property type="nucleotide sequence ID" value="XM_016906886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QDM4"/>
    <dbReference type="STRING" id="692275.N1QDM4"/>
    <dbReference type="GeneID" id="27904023"/>
    <dbReference type="eggNOG" id="KOG2858">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025524_5_1_1"/>
    <dbReference type="OMA" id="HKRLAWT"/>
    <dbReference type="OrthoDB" id="272357at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070761">
        <property type="term" value="C:pre-snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048254">
        <property type="term" value="P:snoRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23023">
        <property type="entry name" value="zf-HIT_BCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.190:FF:000001">
        <property type="entry name" value="box C/D snoRNA protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051639">
        <property type="entry name" value="BCD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057721">
        <property type="entry name" value="BCD1_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483:SF11">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25790">
        <property type="entry name" value="BCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="15">
        <location>
            <begin position="13"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="185"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="243"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="259"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00077531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMF09580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="406" mass="45559" checksum="0E82C0D1BA021868" modified="2013-06-26" version="1">MTMPDAALLTDLCSICYENTPKYRCPRCQTKTCSLPCTQKHKQRAACNGVRDPAEYLKRSQWATPAGIDRDYNYLKGVERSIDVANREREERGVDVVGRAATKSLAQARHPDSALRKYYVENRIDIRQAPNGMSRQKANQTRYTKRHLILWTVEWIDSDGNKDISDSCRHNSTIVDLYALKQIEQSNAMKRKPGETPRDASKRRRKAKQAASKEASTAEEPEAVPDAIETTTGSEILPAGDSPHQDADEHQVPTESKSDTSSTQPSLQGPATIAESRENEETVDPCLHFYLLKPGTTSKEKVLISLNRQATLTSCLRDRTVLEFPTIYVLPHEPTSLPPEYMLESTYLQLQKSEKQELREAVASAEEKGAFQRVRSAQAQASSARPSVPLDANSILNVLKRDMTRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDZ9</accession>
    <name>N1QDZ9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Voltage-gated potassium channel subunit beta-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_150566</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shaker potassium channel beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758586.1">
        <property type="nucleotide sequence ID" value="XM_016906259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QDZ9"/>
    <dbReference type="STRING" id="692275.N1QDZ9"/>
    <dbReference type="GeneID" id="27903396"/>
    <dbReference type="eggNOG" id="KOG1575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_0_1"/>
    <dbReference type="OMA" id="YLPWSPL"/>
    <dbReference type="OrthoDB" id="1720422at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19143">
        <property type="entry name" value="AKR_AKR6C1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005399">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150">
        <property type="entry name" value="HYPERKINETIC, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150:SF2">
        <property type="entry name" value="HYPERKINETIC, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01577">
        <property type="entry name" value="KCNABCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="28"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF10465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="350" mass="38860" checksum="FDF535A27EBF38D1" modified="2013-06-26" version="1">MAAVESKFDPKDMEFRHLGPTGLKVSVLSLGGWLTYGGTQKGNVVKDCMEAAWNAGINFFDTAEIYSNGQCEIEMGQALKELAWPRDEYVLSTKVFFGTGRKEPNTRGLSRKHVVEGLKSSLARLQQPYVDIVLAHRPDVGTPMKEIVEGFTQVIRNLNMAYYWGTSEWSAVQIMEATQIAEKYNLIAPIAEQPQYNAFHRQRFEVEYAPLYQQFQYGTTIWSPLASGLLTGKYNDGIPEDSRFATNKAFFEGTIKSLQSEEGKAKINKVRKLTEIAEKLGGNVAQLSLAWCVKNPNVSTVILGATKVAQIEDNIGALKLLPKLTPDVMADIEAILDNKPAAPASFGRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>N1QEP9</accession>
    <name>N1QEP9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="5">PPIase</shortName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_151478</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family. PPIL3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757593.1">
        <property type="nucleotide sequence ID" value="XM_016906842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QEP9"/>
    <dbReference type="STRING" id="692275.N1QEP9"/>
    <dbReference type="GeneID" id="27903979"/>
    <dbReference type="eggNOG" id="KOG0884">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_16_3_1"/>
    <dbReference type="OMA" id="VPFHRVM"/>
    <dbReference type="OrthoDB" id="271386at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF2">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
        <location>
            <begin position="10"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF09472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="164" mass="18176" checksum="E72E3BB6A3CA64C8" modified="2013-06-26" version="1">MSVTLYTTHGNIKLELFCQACEKTTYNFLALCASGAYDGSPFHRLVKDFIIQGGSPAKGSTKESTSIWGENFEDEIKPSLRHHQRGMLSMANKGPGTNGSQFFLTLSAAAHLDGKNTVFGRVLEGWDVLDKIEEIPVDKKSRPQEAIKIQRVQIHANPLADQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1QET3</accession>
    <name>N1QET3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histone H4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_52170</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the histone H4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757643.1">
        <property type="nucleotide sequence ID" value="XM_016909218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QET3"/>
    <dbReference type="STRING" id="692275.N1QET3"/>
    <dbReference type="GeneID" id="27906355"/>
    <dbReference type="eggNOG" id="KOG3467">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109117_0_1_1"/>
    <dbReference type="OMA" id="RISAMVY"/>
    <dbReference type="OrthoDB" id="3919494at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22912">
        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10484">
        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00623">
        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00417">
        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF09522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="141" mass="15177" checksum="7198E14FABC29015" modified="2013-06-26" version="1">MGWRPRSPSAAPSSTSSSIARASPAPAPARSARKTAGPSGLGLGLGRKPARRHRKILKENIQGVTKPAIRRLARRGGVKRISGDIYDPIRQSLKDYLTKALEKIIAITEYRNAKTVTALDVVFGLRQIGQTLYGFGVGNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFE8</accession>
    <name>N1QFE8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">prephenate dehydratase</fullName>
            <ecNumber evidence="2">4.2.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_149758</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>prephenate + H(+) = 3-phenylpyruvate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:21648"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="4.2.1.51"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-phenylalanine biosynthesis; phenylpyruvate from prephenate: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.51" evidence="2"/>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760043.1">
        <property type="nucleotide sequence ID" value="XM_016905753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QFE8"/>
    <dbReference type="STRING" id="692275.N1QFE8"/>
    <dbReference type="GeneID" id="27902890"/>
    <dbReference type="eggNOG" id="KOG2797">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035008_5_1_1"/>
    <dbReference type="OMA" id="YPNITIC"/>
    <dbReference type="OrthoDB" id="983542at2759"/>
    <dbReference type="UniPathway" id="UPA00121">
        <property type="reaction ID" value="UER00345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004664">
        <property type="term" value="F:prephenate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04905">
        <property type="entry name" value="ACT_CM-PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13532">
        <property type="entry name" value="PBP2_PDT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000034">
        <property type="entry name" value="Chorismate mutase/prephenate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008242">
        <property type="entry name" value="Chor_mutase/pphenate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001086">
        <property type="entry name" value="Preph_deHydtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21022">
        <property type="entry name" value="PREPHENATE DEHYDRATASE P PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21022:SF19">
        <property type="entry name" value="PREPHENATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00800">
        <property type="entry name" value="PDT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001500">
        <property type="entry name" value="Chor_mut_pdt_Ppr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51171">
        <property type="entry name" value="PREPHENATE_DEHYDR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate dehydratase" evidence="9">
        <location>
            <begin position="8"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="10">
        <location>
            <begin position="296"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF11922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="387" mass="42599" checksum="CBFA83BBFAC84D89" modified="2013-06-26" version="1">MPDQASEIVAFLGPRATYTHQAALSVFSADKYNLQPRINIADVFSAIQNGEVRYGVVPFENSSNGSVIFTLDLFVDAQNRHPDILVEGEIYLPVHHCLLAKPARSDSKLAASSSSISERERAFRKFPDEASGTCTPTQAAPIPPKPRVKPNQDISHITKLYSHPQAWGQCKLFLNTYLKGIEQQDVSSTSRAAELVAQDETGTSAAISSRIAGDVNNLDILAEGIEDKEGNTTRFFILRNRQDVFATAASQSPISEPNSSSAVASTALHNTLDDREDDDNNEKEEDEEQKYKTLISFTVNNHSEPGALADSLAVFKKYHLNLSSINSRPSTESAWHYVFFVEILGRKLHREGVEGGGKVNRALEELGAVAREWRWLGSWENKLAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFS1</accession>
    <name>N1QFS1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WSC-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_149907</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760279.1">
        <property type="nucleotide sequence ID" value="XM_016905846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QFS1"/>
    <dbReference type="STRING" id="692275.N1QFS1"/>
    <dbReference type="GeneID" id="27902983"/>
    <dbReference type="eggNOG" id="KOG4157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014722_3_1_1"/>
    <dbReference type="OMA" id="DRVSFAC"/>
    <dbReference type="OrthoDB" id="74764at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF3">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109825" evidence="1">
        <location>
            <begin position="22"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="2">
        <location>
            <begin position="380"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="2">
        <location>
            <begin position="504"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="2">
        <location>
            <begin position="622"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF12158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="721" mass="76825" checksum="23C2CEFC6D2927CC" modified="2013-06-26" version="1">MQKTQVLRAALALTLLGSADAFWRMNCAMIQRGRIDTLVNPGAIAAHTHSIIGGSNFGINATYDSLLNSECTSCEITADKSAYWTPTLYYSYPNGSFLEVPHTGGVAYYLGRGPNANQTVPFPKGLNILSGDKSARSYDNKTYTWGNATFPGRPIADRVSFACLKDNQPPERPYMFDTDCPYGMRAQIHYQSCWNGVDLYKADNSHVAYQSQIDNGICPPTHPIQIPHLFLETLYSVANVPKDPKGQFVFSQGDPTGYGFHGDFQNGWDTDVLAKAVTDCLSVPNYGTIEECPILQSFQTSGYSYNCPERPRQIGEDVKGMISKLPGCITITPGPEAAPAASMSCPDSVPKPSVTSTKDSTAVAMATASPGATWGTTDSFVKYVGCFNDTGGSVRTLNAVSVSNSSAMTVDYCNSYCKSRGYRLSGVEYGQECFCDNAIKSTAVMGSGCTFNCAGTMTNGGPQQICGGLSFISIYNNTDPSFVANGSNKNSAGNVPQDLPVVTKPNYVGCATDNYNNTGRTLTGASLSQLNMSSSICQNFCATAQGGRGWQYWGTEYGSECYCGNTLSGTNFLTTPTTSITNATCNKRCTGVGDEICGGPNALSLYNNTAYIAPSVKSPIGKFVQQECLTDPGLSGGRALANYSFTSTTMTAEVCVRKCEERGWGFAGVEYGTECYCGSVINTASGAKKISCDIAKLMTCGGDVKQFCGGSSLLNLYSSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFY2</accession>
    <name>N1QFY2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_149920</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760298.1">
        <property type="nucleotide sequence ID" value="XM_016905856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QFY2"/>
    <dbReference type="STRING" id="692275.N1QFY2"/>
    <dbReference type="GeneID" id="27902993"/>
    <dbReference type="eggNOG" id="ENOG502SH73">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007091_1_0_1"/>
    <dbReference type="OMA" id="VYNQEMR"/>
    <dbReference type="OrthoDB" id="4236860at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051430">
        <property type="entry name" value="Fungal_TF_Env_Response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944:SF130">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTO (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="35"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="683"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="779"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF12177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="799" mass="88751" checksum="769AFBB494794C7F" modified="2013-06-26" version="1">MPTDPFLPEGRQFPRTRSPDAGGGSDRKRRRKVLSCYDCRRRKLQCDRALPACGRCTKAGQAANCLYLEDATDAPIREEPLVTPGSHKLPPFYGLSTRPIGANAPSGDLLSRLEYQDGRIKQLEAALVKAGAPSGKAQMPPTPESMAGNGALDTMAPVQDRETTLLRGHSFRTQFHGNTHPGALIARIPELHVFTRETFEQFPALSRIKEDMASLEVRTEYAGSKHGSVEDEALKSLLPPRAESDQLIEIYLENYGNLYNVLHLPSFWTEYRDMWNQGTPSAKPHFVALLLAMMAAAKCLSTTSPWLYRANSSTARETAISWVSSVDDWLVSQSQKHVSAIDFQLRVVLLLAKNVTARKFKRTWTECGNVLRFCMAAGLHRTPELIRRPTSVLDKELRKRVWAAVTELELQASFDRGMVSAPWNLQSDCPGPAHVHDDDIDQETQHLPAMRRFNDFTPTSFLCLASESHQLRATLNTYLNNIRQPVLFEETKRYTDEIEYHLQNIPDWPEAPSAAMVPKAMLEINLRQLLLVLHDRQLRTAETKAERDFSRMILVETATKMVQAHKALTSKGSYALELLCYDQLRAGMSLCHISATNPHSDDALGHAIDKAAFDLVPECCEMLTDKVIRFGREQRQLWILLAAHGYMKSKKDPSKKLIYMQEAVEKVTRPYYKIMACQENAPAQPSVPKGTATTQMAPPPRQASTPREAGMSQAHSVMSFYASSTAGQATAAGGNAAMADPTAPLDLDELAAWTFEDWSFNPADLAAMNMSGNFGQTPQGGGGGIETFDGAAQYPDRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFY9</accession>
    <name>N1QFY9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase family 105 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_164499</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760359.1">
        <property type="nucleotide sequence ID" value="XM_016908119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QFY9"/>
    <dbReference type="STRING" id="692275.N1QFY9"/>
    <dbReference type="GeneID" id="27905256"/>
    <dbReference type="eggNOG" id="ENOG502QV67">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038720_1_0_1"/>
    <dbReference type="OMA" id="TAWDDIM"/>
    <dbReference type="OrthoDB" id="540611at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052043">
        <property type="entry name" value="PolySaccharide_Degr_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33886">
        <property type="entry name" value="UNSATURATED RHAMNOGALACTURONAN HYDROLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33886:SF9">
        <property type="entry name" value="UNSATURATED RHAMNOGALACTURONAN HYDROLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013311446" evidence="2">
        <location>
            <begin position="16"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF12238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="382" mass="43052" checksum="E124332D01D9719C" modified="2013-06-26" version="1">MKSSWLLTSLSTAAAALTPAEYLTWAADTYIREGVKKDYHYTTSVLYTGYEAAIALTANETLVDWYRSQIDDAVVLQNGSIAKWNLTKYSLDDYRMGNNFLWWYNRTGEAKYKSAADIIREQLNRHDRNKEGGFWHRNPTYPNQMWLDGIFMADTFYAQWTSLFDSANTTAWDHIALQFDLIEEHCRNHTSGLLVHGYDESKSTVWADPVTGAAPNVWSRAVGWYFIALLEVIPLFPATHPAKARLQKYFVTLAEALKSHQCSESGGWWLIMNDPYPGMEGNYIESSGTAMFTYGFLKGIADGYLTAGDYYASAEKGYTLLTDKFVLNNTNNGTMRMEGTVSVGSLSGNGTYEYYIGVPTAVSDYKGVGPFMWASQPLLHLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGB4</accession>
    <name>N1QGB4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_126602</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760463.1">
        <property type="nucleotide sequence ID" value="XM_016902086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGB4"/>
    <dbReference type="STRING" id="692275.N1QGB4"/>
    <dbReference type="GeneID" id="27899223"/>
    <dbReference type="eggNOG" id="KOG1286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_8_0_1"/>
    <dbReference type="OMA" id="FLDYGMI"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF15">
        <property type="entry name" value="GENERAL AMINO ACID PERMEASE AGP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="6">
        <location>
            <begin position="2"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF12342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="374" mass="41076" checksum="AD9E58EEC3E97714" modified="2013-06-26" version="1">MAIFKVFLIGICLSFTFVTMLGGNPIHDRYGFRFWNEPGAFVEHLVPGSTGRFLGVLSCIVQATFTICGPEYIAMVAGETASPRRVLRKAYRSFVWRMLFFFVSSSLAMGIVIPYNDETLSAVLSGDVAGSGTGAASPYVIAMNRLKISGLPHLVNALIMTSVLSSGNGIFFAATRTLDGMALAGHAPAFFSRTLKNGVPVFSVFAILAICCLAFLQVSASSAKVLTWLVDLITAAQLLNYFAVALTYRHFYAALIKQGVDRRTLPYRGKFQPYTSHIAMTGCMIMMLLLGYDLFIVGGWSTTFFFLDYTFLAAFPMAFVIWKVVKKTRYVKMGTADLSVGGLVREIDLYEQLQPEVRSKGLWSSVRSRKLASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2023-02-22" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGI5</accession>
    <name>N1QGI5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_72565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757779.1">
        <property type="nucleotide sequence ID" value="XM_016909998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGI5"/>
    <dbReference type="GeneID" id="27907135"/>
    <dbReference type="eggNOG" id="ENOG502TH3D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1082453_0_0_1"/>
    <dbReference type="OMA" id="AMICNGP"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF09658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="257" mass="27765" checksum="C42071398C7C91CC" modified="2013-06-26" version="1">MSGISCAGPFPGSTGLNYHEAKTLVSGFCEATNSHVIGLSTNETDTLKTAWGNSNILLSISYTTARHTYDTSCSLDAHAELTVRAKICEQAFYRLLDECDTSPSGNLGKYGGTVSSGCGVYTLSTQPEEIVTCGGNPYPRSIDMPLKTMEQGVADYCNRPLELTPDYIYTNTFLVDIPKGQSHGNFLKNDIVVKTVTEFNDQGQTNCAYSKPFQTNGEECKRKLTAVVDKCGGEGGSLSENGKYGCVLWTIWGQHAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1QH42</accession>
    <name>N1QH42_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_149658</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759890.1">
        <property type="nucleotide sequence ID" value="XM_016905693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QH42"/>
    <dbReference type="STRING" id="692275.N1QH42"/>
    <dbReference type="GeneID" id="27902830"/>
    <dbReference type="eggNOG" id="ENOG502SSWB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_731912_0_0_1"/>
    <dbReference type="OMA" id="ARITKCT"/>
    <dbReference type="OrthoDB" id="3644751at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="258"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="320"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF11769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="378" mass="39435" checksum="5672858563588033" modified="2013-06-26" version="1">MNLTWPSKMLLYLYNTRSQVTMSLARLRTVLLLALFSGATVESSQAPLITPAPVARGLLPRQVDDPGPTCGYVNADILQAQYCQNGFTCFAEPTFRAAGGCCRLGDGANCQLPTSCVPQASLSQSCNAACSANARITKCTDSASPYCYTNYWPTAGQTLLNVGCTTAQGQFSFIYTTYTLYGQGFSDIVASTQSGSPIPTFTNTDTSAIATETGNASANNNDDDEEVAAGTSSNSNSGAVSNSQITTNDTSGGSSTNVGAIAGGVVGGVAALGLIAALITWIVLRNKRKERKVDTTTTSKGGGGEVGGGGGALENHMNDPKSPVSTAVSPSVSPHVHSRDEPVSNELQAGDSRFEVPGYAEPQELQHHHAQRRFPELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1QHE9</accession>
    <name>N1QHE9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS10m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">37S ribosomal protein S10, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Mitochondrial ribosomal small subunit protein 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_133845</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759990.1">
        <property type="nucleotide sequence ID" value="XM_016902592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QHE9"/>
    <dbReference type="STRING" id="692275.N1QHE9"/>
    <dbReference type="GeneID" id="27899729"/>
    <dbReference type="eggNOG" id="KOG3321">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051208_2_1_1"/>
    <dbReference type="OMA" id="MRAAYFL"/>
    <dbReference type="OrthoDB" id="366214at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.600:FF:000003">
        <property type="entry name" value="30S ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="entry name" value="Ribosomal protein S10 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_uS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="8">
        <location>
            <begin position="81"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="240"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00078476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF11869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="283" mass="31827" checksum="90673A125116B1DD" modified="2013-06-26" version="1">MATPSYARSLTSAVKRLKLSTICTTPTQTRSIQHSRPRSAQPLPSELQSELARIRLPKAVQATYLAPLRRRTRVNADTVCKLQLRSYNVRNLEVFTDFALRAAYFLNLSVRGLRSLPKKTERWTVPRSNFVHKKSQENFERITMGREIQIKDGHSDVVATWLAFLRKHQYYGVGMKANVWDYGGLDAPTEMDEEAAKVAQMLGEVPLVKLTNGKQHGENLQKLLIDEPFKASWGAYTPSSGATTVPHGNHRVPTKSVHTPGLIKKATPKEATPNTEEKEQPQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1QHF0</accession>
    <name>N1QHF0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_32835</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764736.1">
        <property type="nucleotide sequence ID" value="XM_016908512.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.N1QHF0"/>
    <dbReference type="GeneID" id="27905649"/>
    <dbReference type="eggNOG" id="ENOG502RPXF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_263160_0_0_1"/>
    <dbReference type="OMA" id="WSKRCQF"/>
    <dbReference type="OrthoDB" id="2322499at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057214">
        <property type="entry name" value="DUF7892"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25422">
        <property type="entry name" value="DUF7892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="107"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7892" evidence="3">
        <location>
            <begin position="770"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="708"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="965"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1110"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1192"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="965"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1110"/>
            <end position="1130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF16615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1355" mass="150613" checksum="77645C8F72BB30FE" modified="2013-06-26" version="1">MIDEDAVDDEHDDEASSGMDLSEPSRSVTPTSPNATAAQATVAPNHAGSKKRKLSDADGIADGVAKDLADEQTKKCKLSADKFSRSPVVPSNKNMSVSEALCQSPAVLQLIFTHLPPAMLCRCLRVCKQFNHLLTGARAPQGKQKAKSAARIVDSEAIWVRSRKTYFPQLPRPLRNRTELQMLQLVGGRACQFCRRPPVPLSAPSIFNGGPGTKGVRVLFPFGVRTCGSCIEPLVRKDVHALAEPVAARLRMGITYAFRNDELHYMTETVRQAFSSFPETTRFSKVYYHPDLVAIEHEEKDAQQLGEGAYDEWRKGLYNRGRSAMADCARWENWETGVRLGANLAQVLREYDLSSFPLHVKATQSSSAHAKAAHAGLILPITGPHPLPEPVHVFNNGNQPSFPMHQQLGRPAPQQHPLPFPPALPLRPLVYPVVNQPQQRMARSLQEVESARQARKADIERRCSALEPPLEPAVLQHMESFQAAMQITTPLTDAAWDMLKPRILAQREAAELAEHARASQLAALQAAVPLHWPDDIISRPAKEMYDRGYEDAQMPLRKRLGEYADDITNGQWGGGKMLDRDNVPIFAIHVLSHVHQRYEEDKQLGLLSDLEPVANKPGTTQGSPSPTPFLSLDNMKWVYDHKVRLFTDTHRKELFICAGCDDKRPKWFAFEGLVQHYGAKHTSEFSRGNIIVHWQTAKWPDKPPFHTNPAQWFKHRPRHAPVPGGDTRDQYSPASFPGQNGYDAGFLSQYASMGVGNTVRQVNGTASEDDWQHIKLATDAREIWDALDGIKDLLECVKVQTVLHHAVAKFSDHYHYKPTLDLLTVALASHNVTRPLRNVTGLACKSCVAVGQHSHSNSYWTRIRGIKLLSTSHLITHFELMHQAHENAGPLDWVKEMIELPEKQSLKELLHTPGMDDNKLALIAAALPAGTFPMPLPVIGHVTEKRKKSSVSDEASFENLIVRKKPKKHSKKLQKASNSLLGRDGSQETLPEVKEEEYDPLRPALIPARKWDPALFDTDARKPPEPVAPVTQAPPQEFTFNRETIAMPEKNNPTPALDRATRCPSVGRAHAASTTQTPLAAPNITPDGQPDIAAIIAALTAGRHSVLAAPTAPGQAAASPAPPGESSGIAHDQSFAEAHGRDPRELQSGGQTDAYAPAPRYFPTQQAHPQPAAVPSVHELQAALSHNHWQYEQNHHHSGTARAYSTGPQPQQHRPPPQPVPQYQFVYEEDRPYSQAVPYAANYREAPSPQYVQVPRHQYAPHGYHYEVPVPQTIYVDQDGRRLIPIDAAPAPVQYFSNRYEQQHYVRPVYTSAVPQPAVQAVYDDRRPVYYERTASVIPPRYAYDDRASVGRSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1QHI5</accession>
    <name>N1QHI5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_34509</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the membrane magnesium transporter (TC 1.A.67) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764802.1">
        <property type="nucleotide sequence ID" value="XM_016908573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QHI5"/>
    <dbReference type="STRING" id="692275.N1QHI5"/>
    <dbReference type="GeneID" id="27905710"/>
    <dbReference type="eggNOG" id="ENOG502S8V0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132206_0_1_1"/>
    <dbReference type="OrthoDB" id="44756at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053279">
        <property type="entry name" value="EMC_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018937">
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    </dbReference>
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        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF16681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="91" mass="9997" checksum="3D656B4849975F50" modified="2013-06-26" version="1" fragment="single">IPTDIVLETIFSVLLLCVGVVLSSPDLKPIQWSVWAGSLERSKEAREITAVGVGGGNPFAVLEERPGFLDIRKTRDDFARWRKEGGVSEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1QHL5</accession>
    <name>N1QHL5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_145905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502S7FQ">
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    </dbReference>
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    <dbReference type="OrthoDB" id="2253354at2759"/>
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    </dbReference>
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        <property type="entry name" value="DUF5321"/>
    </dbReference>
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        <property type="entry name" value="DUF5321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF16731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="186" mass="21560" checksum="18B4F3C4A6ADBC78" modified="2013-06-26" version="1">MATMRTLSDEQTRLPRVVNLSFWSSLVPRFLRRATTEEEAAARAKRRNIGAEEKRTGLIFLLLGILVGSNAINIIGVKREMLNFTRQTDAKLELLREIVERVKRGEDIDVKKALGTGDVEQEREWEQVIQELERTDMLLEGRKKRDAKRAEKAEQARLRDEERERSKQDVKTTTDEPPASRPKFLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>N1QI99</accession>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_51528</name>
    </gene>
    <organism evidence="2 3">
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        <name type="synonym">Septoria musiva</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757825.1">
        <property type="nucleotide sequence ID" value="XM_016909194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QI99"/>
    <dbReference type="GeneID" id="27906331"/>
    <dbReference type="eggNOG" id="ENOG502RNVX">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2039056_0_0_1"/>
    <dbReference type="OMA" id="NAYCEAC"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="148" mass="15638" checksum="1C4BD50859675D6E" modified="2013-06-26" version="1">MCHTIKTRLTCGHFIHGPIIQCAEAAATAAAAAAASASSSRPTPHPRNNAAGGRGREEICQPGITINTQTTACCDDCVTGFSRQFLESICRRCRRGVVHGMALAVLESLPRRTNEEEEHAVSNSSSTSSSSSSSSSSAAEEEAEYSHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1QII1</accession>
    <name>N1QII1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Potassium transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_164050</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759746.1">
        <property type="nucleotide sequence ID" value="XM_016908095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QII1"/>
    <dbReference type="STRING" id="692275.N1QII1"/>
    <dbReference type="GeneID" id="27905232"/>
    <dbReference type="eggNOG" id="ENOG502QPSA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008142_4_0_1"/>
    <dbReference type="OMA" id="VTFITTC"/>
    <dbReference type="OrthoDB" id="504708at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003855">
        <property type="entry name" value="K+_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053952">
        <property type="entry name" value="K_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053951">
        <property type="entry name" value="K_trans_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00794">
        <property type="entry name" value="kup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30540:SF83">
        <property type="entry name" value="K+ POTASSIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30540">
        <property type="entry name" value="OSMOTIC STRESS POTASSIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02705">
        <property type="entry name" value="K_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22776">
        <property type="entry name" value="K_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="353"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="430"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="463"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="490"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="K+ potassium transporter integral membrane" evidence="11">
        <location>
            <begin position="45"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="K+ potassium transporter C-terminal" evidence="12">
        <location>
            <begin position="570"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="688"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF11625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="804" mass="89789" checksum="5B641AF83C117847" modified="2013-06-26" version="1">MEKEVKHLTVSTETSERELDDVDLKIRDGDIRQRQVFKGWTVFWLAYQATGVIYGDIGTSPLYVYSSTFSSEPSRQDLLGVLSIILWTLTLMVTIKYVFIVLRADDEGEGGTFAIYTLLSRYSEIMKRDPRIYQLVKMERYKTNDLHSHNERFRNWLEKSKFAHAMLMLLAVFGVSLVVADGVLTPAQSVLGAIQGIRVADESITTATIIGVSCTILVLLFAVQPLGVHRVSSAFAPIVILWLLFNAVFGIYNLIQHDHTVLKAFSPYFAGAWLMRNKTEGWKSLGGVLLCFTGVECLFADMGAFSRRAVQLSWLCLAYPCLMLAYIGQAAHLVDDPSGYSNPFFNTVPPGMFWPSLVLAILAAVVASQATITACFQLIAQIMNSSYFPQIQMHYTSDKYHGQVYIPIANWLLMIGCVVVTAVFNNTTSLGHAYGVCVILVTFITTNLVALVAVIVWRLHPALVFLVWLPFILFDGVYLTSSLLKVPDGAWFTLMLATSLAAFFLLWRYGKETQWVCEAKDNTTRLSSLIFPTGAAATTTTTTEPARFGYEGEGQRLTEKYGSHPLLSTPGLGIFLDKSGIFTPKVYEQWLCKFRSQMQVVVLMHLRALNKPHVAEEDRFEVEVVKGLTNVYRLVIRHGYNDHDVMNPGLAGEVVRVVKGEVIREGLIGGREVDINEEEEEVAVVAKDGEDDDDDDAHDTISPVVHPGHNSTTTTTRKRITRTSPRTTTTISTSHRLSALEAASSAQTLYLVGKQQMRISASYNIFKKIILGVFLWVRENSRSKMEKLNVPMERLVEVGFVGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1QIL0</accession>
    <name>N1QIL0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA ligase/mRNA capping enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_86728</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SO2202</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2012-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genome evolution in poplar pathogens from wild and recently domesticated pathosystems.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Dhillon B."/>
                <person name="Feau N."/>
                <person name="Sakalidis M.L."/>
                <person name="Gill N."/>
                <person name="Aerts A."/>
                <person name="Ohm R."/>
                <person name="LaButti K."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Copeland A."/>
                <person name="Beauseigle S."/>
                <person name="Grigoriev I.V."/>
                <person name="Goodwin S.B."/>
                <person name="Tanguay P."/>
                <person name="Hamelin R.C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759776.1">
        <property type="nucleotide sequence ID" value="XM_016910421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QIL0"/>
    <dbReference type="STRING" id="692275.N1QIL0"/>
    <dbReference type="GeneID" id="27907558"/>
    <dbReference type="eggNOG" id="KOG0967">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004299_3_0_1"/>
    <dbReference type="OMA" id="RIDEFWR"/>
    <dbReference type="OrthoDB" id="2160351at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032807">
        <property type="term" value="C:DNA ligase IV complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029710">
        <property type="entry name" value="LIG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45997:SF2">
        <property type="entry name" value="ATP DEPENDENT DNA LIGASE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G02430)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45997">
        <property type="entry name" value="DNA LIGASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="6">
        <location>
            <begin position="398"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF11655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="683" mass="77659" checksum="EF5A8ADA38470EF0" modified="2013-06-26" version="1" fragment="single">MSFPFKEVCQLLDRLETVELHENLLPSAKPDRYKELVNSWFSSHRRQINELDVLGSCALLSTLVPHWRTDRVYSLQAAGLCRILGRALGLSTARRTSLAAYTQPGAGDLATCFERVHAAGGPPATPAVTVEHVDHMLHSLAGRSSFSDPSIARLPPSSSETRDRLLSNVFCRTSPQEGKWLVRLILKDFRPVQCDETIILKSFHFLLPDLLRFQRDFTAAVTLLKNELKQYPEKPDPRSEALHRKTIADARTIRPVVGTKVSRPHFHKGRGIDSCMKMMGSKVWVLERKYDGEYCEIHVDLTKSTNPIDCITIFSKSGKNSTRDRKAILKTLVETLRLGTPDCHFKKQAILLGELVVFSDQDDCIMPFEEIRKHVSRSGVFIGTEQDSMPKAHEHLAIVFFDLLLLDDEVVMNKPINERRDWLRVAYKKIHGRAMGAEWTKVDFAQPERAKRLFLQHFAMSNAKRCEGLVLKPCDVPYFSIEAHPADYRHSYIKLKKDYISDMGDEEDFAVVGASYNAQQAATAGGKAFIKWTTFHLGCLTNKEDVRKYDARPIFKHVGTIDQQHCIPQAILETANILGNLRASPWTESEPPQNFDLEATRSSKISVVFDKPLVFEVLGAGYERPSSCDYLMLRHPRVKKLHEDRDWTDCVTFQELQKKGRASRAAAVDSESQEMQRWIDKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1QIW5</accession>
    <name>N1QIW5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycoside hydrolase family 5 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_75098</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764328.1">
        <property type="nucleotide sequence ID" value="XM_016910097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QIW5"/>
    <dbReference type="STRING" id="692275.N1QIW5"/>
    <dbReference type="GeneID" id="27907234"/>
    <dbReference type="eggNOG" id="ENOG502QVVM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004624_8_2_1"/>
    <dbReference type="OMA" id="KWYDEVL"/>
    <dbReference type="OrthoDB" id="1887033at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046557">
        <property type="term" value="F:glucan endo-1,6-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000100">
        <property type="entry name" value="Glycoside hydrolase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF43">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109910" evidence="6">
        <location>
            <begin position="25"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="7">
        <location>
            <begin position="138"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF16207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="587" mass="66713" checksum="939440094E7915F8" modified="2013-06-26" version="1">MPISTPSYCLTGFFFSVVLFLALKHLVPWPQVIHFAEPRMKRILHKAKSIANNGRSQEAAPIDPSQQHIPTHDGTMDEERFTVDPVTLQDVTRYRYHHGVNLGSIFILERWLTPSMFSELPKLGSSELAAAEYNIQRFGLEAAREKQERHWREYVTDADLDWLRDVGKCTTVRLPIGFFTLGPEWCKGTAFEKVAPLYQNAWKNVRSLVARLHERKIGTLIDVHGLPGGANKNEHSGTNSNKAEFWSSKKNLELGTRVMCFIAEEAKSMAGVAGLQIVNEAEWSHNSKSGWKWYDDVLRAVGAVDPTIPIYVSDAWFFLKAAVQWSRTRNMAKTGCNPVVLDTHLYWCFDPRHESQTPYQIIDDVRTKLSELDGNEGSVHKEGAAEVIVGEYSCVLGERTWAKSGGKSKEELVRLFGHAQSAQYQQRAGGTFFWTYKMDWMPGGEWGFKQMTEQGAICCPAHLAMPASEVAARLSEARQHQSVARKSEDVAKHISFWDARGSGSYEHWRYEMGWTMGWNDAIAFFEARSRHFGLEGCDKIGMLDLWILKRLRDCRQTGEFVWEWEQGFRKGVQSFYETVGISGHDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJB7</accession>
    <name>N1QJB7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_150681</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758770.1">
        <property type="nucleotide sequence ID" value="XM_016906331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJB7"/>
    <dbReference type="STRING" id="692275.N1QJB7"/>
    <dbReference type="GeneID" id="27903468"/>
    <dbReference type="eggNOG" id="KOG2571">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004760_1_1_1"/>
    <dbReference type="OMA" id="TTMRETE"/>
    <dbReference type="OrthoDB" id="26569at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902404">
        <property type="term" value="P:mitotic actomyosin contractile ring contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF38">
        <property type="entry name" value="CHITIN SYNTHASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="814"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="850"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="884"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="927"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1053"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1087"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="11">
        <location>
            <begin position="392"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1123"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="126"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="142"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="200"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="234"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="329"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1123"/>
            <end position="1168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF10649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1175" mass="131196" checksum="F0CF54CBB9F6D0AC" modified="2013-06-26" version="1">MAAPNRPHAYEPPPGYDDDFDTPTNASTMRLLTSPEESAHAASVSPSREAANHHSNNNNNRASPHDLFLRAQDRLNSRNHQRADNSSQDAPLPSATTHSHYARSQAPPGEELNSLLREVESDLSQSSAARSSATSSSAAPPRTKRYKVRFNQHQRHDVDDQQPEEEDIGSYNLYSSRPDSPTRSYRPPSPTRSYAPTSTLGTQPSFSRLSRQPSVLDSAPDMAPPVDAYDPYRPSSSRQSDSPTKAFTPRGSREYPRPPASNVPYEPADINGVPRPGTPSSAYGGSPRRPLPPQPLFAGGRPPSMISMEEPQEPGITAIPIDDDDDTADPFGPAAGDGDLQRPRPVSRNTFQSESTVTDDKEFDNKDPEDDLCGPAPDGVHRRRGARPAQMTRKEVKLINGELILECKIPTILYSFLPRRDDVEFTHMRYTAVTCDPNDFVDRGYKLRQNIGSTSRETELLICITMYNENEIDFTRTMHGVMRNLSHFCSRAKSRTWGKDGWQKIVVCIISDGRSKVHPRTLDALAAMGCYQSGIAKNLVNQREVTAHVYEYTTQVSLDSDLKFKGAEKGIVPCQVIFCLKEKNSKKLNSHRWFFNAFGRALNPNVCILLDVGTRPGDDSLYHLWKAFDRDSNVAGAAGEIKAAKGRYLKALINPLVASQNFEYKMSNILDKPLESVFGYITVLPGALSAYRYHALQNDETGHGPLSQYFKGETLHGQDADVFTANMYLAEDRILCWELVAKRNDRWVLKYVRKATGETDVPDAVPEFISQRRRWLNGAFFAAVYSLLHFKQIWKTDHTITRKILLHVEFIYQFVQLLFTFFSLGNFYLTFYFIAGSLADKKVDPFGHGIGNFIFIVLRYICVLTIMVQFILSMGNRPQGAVKMFMASLIIFSIIMVYNTFAAIYIVVRQLTNGSEIGFGNNVFTNLVVSTLSTVGLYFFMSFMYMDPWHMFTSSAQYFALLPSYIATLQVYAFCNAHDVTWGTKGDNVLKKDLGVATANKNGTVELEMPSEQLDIDSGYDEALRNLRDRVEVPTPGISESQMQEDYYRAVRTYVVIIWMACNAVLAMAITEIYSNTDVGQNYYLKFILWSVACLALFRALGSTAFLIISGVHSIADGKLKWSNKSGSSTSKSVRSGGSWTSKVSMPSWMSSTGSWMSSKASSWTPSSIGSTLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJD4</accession>
    <name>N1QJD4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_149753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760036.1">
        <property type="nucleotide sequence ID" value="XM_016905749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJD4"/>
    <dbReference type="GeneID" id="27902886"/>
    <dbReference type="eggNOG" id="ENOG502SPD0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117282_0_0_1"/>
    <dbReference type="OMA" id="CTFIVEA"/>
    <dbReference type="OrthoDB" id="5352317at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109920" description="Small secreted protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF11915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="149" mass="15842" checksum="482D19148543F9D5" modified="2013-06-26" version="1">MQFTTTVLAFLAAASTSLATPVPEPAVGVSMMAAAGTTWTIQNFKRTCTSDAKSCNYSFGINTNDGSAATKCSYQVTGNPAARASYNSVACGNFRIGSTWSNQFGAGQEFQTLSVVRNGQIIYPAYKDSQIVNGKTVKPDQSYTPQRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJH1</accession>
    <name>N1QJH1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_57663</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ING family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765471.1">
        <property type="nucleotide sequence ID" value="XM_016909445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJH1"/>
    <dbReference type="STRING" id="692275.N1QJH1"/>
    <dbReference type="GeneID" id="27906582"/>
    <dbReference type="eggNOG" id="KOG1973">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009357_1_0_1"/>
    <dbReference type="OMA" id="EVMIHRE"/>
    <dbReference type="OrthoDB" id="5411773at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15505">
        <property type="entry name" value="PHD_ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF94">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="11">
        <location>
            <begin position="628"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="132"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="407"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="464"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="494"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="527"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="573"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="631"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="633"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="644"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="650"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="656"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="659"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="674"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="677"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="7">
        <location>
            <position position="630"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="7">
        <location>
            <position position="641"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="7">
        <location>
            <position position="645"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="7">
        <location>
            <position position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF17350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="692" mass="75815" checksum="F054D9EDFEA5154B" modified="2013-06-26" version="1">MATALSHASVDDLRSLSRQPPSDPDIQATLSDFLTYTEHFPSHLARALNLVQEQRNKAEKNIGAVHGDTTAYSILPSIKHGRPDPVQLRKDISLALEEAEGACRMSVEEALRLDHECQREAQRLDVVNEKLKAQPKPPSRDPTPEQQALTSPNLKRERRMSSRVDDGKSEKQSRRMQDKAASKLRGRKVMVPGEVLPPPDPNALLETMSDWTSPRPSPSLLDDPMDQDIKKTTPPRAPRAPGQPGTNAHSAVAGISTSNALLALTEPPADAAKGSKWLPWIKLTEWEMAKLRKRMKKNAIWVPSQTMVRRELKNLGRGLVGKEAARQQAEANGTSLIDEHNEVDPTKVMISGEETDQINAMLGPQVYADDDDADAELINRGMRLNEAKKLKKQRLLEEQALQAQLAREQGVEYHPEGSKSLLGSPENQKKRKREATPAVGSSKIANPKSPEVKANPVKRLKLTGPSSAPTTSKIPLAPAGVPPSSKPATSSRSRQAATPPATRRPTITIKVGKAVSEEPPNRRQSLRRNSNVSLPSNSVPSASTPTSPKSTGTSKDAITKSGRRSKRPPPGVITNNDNDSAKATISQRKTAPNRKRGQTTKTDSAVPPDQPGLGAVEAPEEYIDPDEPRYCICGDVSWGTMIACDNEADCEKEWFHLDCVQLTDLPPRRTKWYCPDCRKKLKVGQTTNGLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJH7</accession>
    <name>N1QJH7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_152663</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_016907479.1"/>
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    <dbReference type="STRING" id="692275.N1QJH7"/>
    <dbReference type="GeneID" id="27904616"/>
    <dbReference type="eggNOG" id="KOG2820">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_0_2_1"/>
    <dbReference type="OMA" id="NEAIHFW"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051698">
        <property type="term" value="F:saccharopine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF37">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="12"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="415"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF16442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="439" mass="48795" checksum="E54ED6A142AF0401" modified="2013-06-26" version="1">MTMTPSKPEQSILIVGAGVFGASTAYHLALQYEDTSKITVIDRTLPSPEPAASTDINKIIRADYSSAFYAELAYEAIEAWANWPELKDYYHRTGWVMLDTEDSDMVDQIRQVFKNRGFDPTEDIPLDKLNDHWKGILKGTNLQGFDKAYWNPEAGWCDASAATASIMNAAISKGVKYVVGEVDQILLDESKVTGIRTTEGEDLTADTIVLATGAWTSSLLSPIEDILSIAEPDRVERQLTAAGVSVAHYKMSSEEMTQLSDMPVVVYAEHGEVIPPPQETQLLKFTNAHTIKNTIVTPSGSHISVPPPNRDQHLVPEVLKKEAIEIMSAKVMPTFTASGARDVAYWRLCWDSYTPTQDWLLCRAPHARLGNLFLATGGSFHSYKFLPIVGKYMVNVLSGKGNGEVKDRAWEWKKRMDGDEKTRGAHESTAPRRELRDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJS2</accession>
    <name>N1QJS2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rhodanese-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_150793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758920.1">
        <property type="nucleotide sequence ID" value="XM_016906400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJS2"/>
    <dbReference type="STRING" id="692275.N1QJS2"/>
    <dbReference type="GeneID" id="27903537"/>
    <dbReference type="eggNOG" id="KOG3772">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107716_1_0_1"/>
    <dbReference type="OMA" id="RGGFTQW"/>
    <dbReference type="OrthoDB" id="102559at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000050">
        <property type="entry name" value="Dual specificity phosphatase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828:SF38">
        <property type="entry name" value="ARSENICAL-RESISTANCE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="24"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF10799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="139" mass="16001" checksum="549BCC02CAA06958" modified="2013-06-26" version="1">MSTYSVANLPRITHETLTPLVREQNASLAVIDVRDSDYIGGHIRGCINVPTATHDYRMPELVRTLKEKDTVVFHCALSQQRGPSSALKYLRERERLHGKEAEQKQKVYVLDGGFQKWQEAHGEDKELTEGYVKDLWENY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1QK19</accession>
    <name>N1QK19_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_135146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759025.1">
        <property type="nucleotide sequence ID" value="XM_016902684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QK19"/>
    <dbReference type="GeneID" id="27899821"/>
    <dbReference type="HOGENOM" id="CLU_1670486_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF10904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="158" mass="17841" checksum="3717FEB522CD7968" modified="2013-06-26" version="1">MFAWGRIVSQQISENVGGTVVQPSKRAGRWRKLYRRCCRLAALPTYHTYHRRTSLVSVKHSMSSRDEQDFPKSSLPSSNDNIASSSSVSRSLPPPDNNVLPVCVLLQGSPYRFDLSRGIEVMAERHEHFERVPERCVRRGLVPCLLLQAPLGAREALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1QK79</accession>
    <name>N1QK79_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Guanine nucleotide-exchange factor SEC12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_149551</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Guanine nucleotide-exchange factor (GEF) required for the formation or budding of transport vesicles from the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endoplasmic reticulum membrane</location>
            <topology evidence="10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Golgi apparatus membrane</location>
            <topology evidence="10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the WD repeat SEC12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759727.1">
        <property type="nucleotide sequence ID" value="XM_016905625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QK79"/>
    <dbReference type="STRING" id="692275.N1QK79"/>
    <dbReference type="GeneID" id="27902762"/>
    <dbReference type="eggNOG" id="KOG0771">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021000_0_0_1"/>
    <dbReference type="OMA" id="EPQLAIF"/>
    <dbReference type="OrthoDB" id="16538at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003400">
        <property type="term" value="P:regulation of COPII vesicle coating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045260">
        <property type="entry name" value="Sec12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23284">
        <property type="entry name" value="PROLACTIN REGULATORY ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23284:SF0">
        <property type="entry name" value="PROLACTIN REGULATORY ELEMENT-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 10" id="KW-0813">Transport</keyword>
    <keyword evidence="2 10" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF11606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="620" mass="68413" checksum="350808EAD28A2C28" modified="2013-06-26" version="1">MPSFTNSDVSYAKHTLDYPIYAAEFDPYTRGFLIVAGGGGEGRSGVPNRISLLDVNNRAVVEPVAELDLSRDEDSIQSLANLATKDGLITLAGINSSQAAQNDNKNEHFRAFDIRYPPRKKQKTAESSGEKGEIKLLGKRSLFKPSSAPKKETYQRLLRLSPVGKRDTPSKRIGAIASGFAQQSEVIVFDATAAIPDDQHIITRIELPEKQEAADLDIARIGDDDLFSLAYCDEHNIYEQTYKYDFASKKVDKRPNGPRRTFQMAGGDNYQAKGSRPKFKALRFLNSENLIALVNKPNKSGAELRLYHLYPTGPALVMQTETLPSHIKQATSLDVGPLDTDTNGNQQFMLAVSGQDRSIEVLTVNYQAVTDTFSSIRCFMTLRNVHAQGITKICWQPFHSPVRTADPGPQYARLASVSFGNTLVIETFPLQLLEKSNKNSRYVLSHPTDELFWTWLKYGLFIFIGLVVAILLQSFLSAESSLNIVPNRVSTGGTHPSADITTPSIAVPSPVTNLKDALLAQAASPEDASPGVVIVHSPSDDHEDVGFAVHPDKEAYLAHESTDAKHWDDLATEQKELWKRKLKKAGQWVEGQGEAVFKGVLWSTVPQFLMGQAGEVLREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1QK95</accession>
    <name>N1QK95_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_56265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764793.1">
        <property type="nucleotide sequence ID" value="XM_016909393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QK95"/>
    <dbReference type="STRING" id="692275.N1QK95"/>
    <dbReference type="GeneID" id="27906530"/>
    <dbReference type="eggNOG" id="KOG2132">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054409_0_0_1"/>
    <dbReference type="OMA" id="WIGHPPT"/>
    <dbReference type="OrthoDB" id="263283at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF105">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="1">
        <location>
            <begin position="104"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF16672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="283" mass="31580" checksum="D00135E51896E6A7" modified="2013-06-26" version="1">MLRRCPLAVSRAQCRRHYSAPINQPRPVRELPDASLETFQHLAFEPAIPALFPRKQFCSLPAVSKWFLRSSKHGHVVLDTTYLSRFGDAVVPLEISNDDGQFARVEQSLSFFLDIPNFTKPTARVYLAQASLDDFPRALADDVPTPEAVLRAGKGDVYGASLWIGQAPTYTPLHRDPNPNVFVQLAGRKAVRIFEPHVGRGIFAKVQEQIGATASPTMRGEEMMQGEEKEALDREVWESAAHIGDCYEAELDSGDGLFIPKGYWHSVKGVGEGMIGSVNWWFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKA7</accession>
    <name>N1QKA7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_145881</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the pacC/RIM101 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764813.1">
        <property type="nucleotide sequence ID" value="XM_016903317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QKA7"/>
    <dbReference type="STRING" id="692275.N1QKA7"/>
    <dbReference type="GeneID" id="27900454"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012842_1_0_1"/>
    <dbReference type="OMA" id="QWGNCRT"/>
    <dbReference type="OrthoDB" id="6155966at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000458">
        <property type="entry name" value="pH-response transcription factor pacC/RIM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001875">
        <property type="entry name" value="pH-response transcription factor pacC/RIM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050806">
        <property type="entry name" value="pacC/RIM101"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47257">
        <property type="entry name" value="PH-RESPONSE TRANSCRIPTION FACTOR PACC/RIM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47257:SF1">
        <property type="entry name" value="PH-RESPONSE TRANSCRIPTION FACTOR PACC_RIM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="83"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="113"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="129"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="379"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="472"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="599"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="157"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="435"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="473"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="524"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="556"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="614"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="632"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF16692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="657" mass="69154" checksum="9BBC12774F164B2B" modified="2013-06-26" version="1">MDASSAPQTVAQAVQAATQQAQAAAAAPSPSVQAAVQSTQSSAIDNLTCQWQGCGERCDSAELLYDHVCERHVGRKSTNNLNLTCQWGACRTTTVKRDHITSHIRVHVPLKPHKCDFCGKAFKRPQDLKKHVKTHADDSVLMNSPQHGAGRSGNGSLGQQNGKPTSYYGSSGHEAMNNPYPSYQQGMAQSANGGSYPQQAGAQYAGYGSVSYPNSSALADIQSMDTRRRAIEALNDFLGDIKRRAIDPSSYYDVGHRLQQGNALPLPVGGGGYNTGYNNSSGYSGGAPSGFNAASFLDSFSGGGGMGGGNGAAHGSVATHGYSLPLPNARTKNDLQDIDRFLEQLQATVYETSKGYETSNSAAAAGVQQPGLHTQFAGDFGMGGHQAQYRSSNSPPQFGNHLGSSGVMSSGSSVHGVTSSSSALDTPALTPASVSSYTSSGHSPMSSHSRASFGSVSGQMYPSLPAVTGMSDMGSNYPTTTSAPASGLASGFEGLDGRRYSGGRLQRQAPDVKTEDTEMEDADDGSRTPKASDSKRPKSKGNSSIDPALRGEDGSGSDSVSTPAAQSEGAEDKRQEEWIENIRLIEALRKWVGDRLKSGDFEEVDQAPESQAGAEEKKVDADKMVEDKLTEAFEQQRQQEQASKQEDAKYPSLPTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKB3</accession>
    <name>N1QKB3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MAGE-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_56330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764823.1">
        <property type="nucleotide sequence ID" value="XM_016909395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QKB3"/>
    <dbReference type="STRING" id="692275.N1QKB3"/>
    <dbReference type="GeneID" id="27906532"/>
    <dbReference type="eggNOG" id="KOG4562">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048908_1_0_1"/>
    <dbReference type="OMA" id="GMQMVEQ"/>
    <dbReference type="OrthoDB" id="205198at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1200">
        <property type="entry name" value="MAGE homology domain, winged helix WH1 motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1210">
        <property type="entry name" value="MAGE homology domain, winged helix WH2 motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037445">
        <property type="entry name" value="MAGE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041898">
        <property type="entry name" value="MAGE_WH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041899">
        <property type="entry name" value="MAGE_WH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002190">
        <property type="entry name" value="MHD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11736">
        <property type="entry name" value="MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11736:SF14">
        <property type="entry name" value="NSE3 HOMOLOG, SMC5-SMC6 COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01454">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01373">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MAGE" evidence="2">
        <location>
            <begin position="62"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF16702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="347" mass="38545" checksum="5ACB39D14FF99945" modified="2013-06-26" version="1">MPLVQGRKRRAVNDQVSSPEASPEPQTQRRRTQGHDDDGEGTFAGDNGTTQTGSTDELAKKLVRLALACEYGRRPIRRQEINEKVLGSFGGRAKLFNAVFQQAQHQLEYVFGMKMIELPAREKITLQQRRAAQKKDSQSQSKATGSWIMTNILPDVFRDPDILSAPAAPTSAVDAEYTAIYTTLVSLILLSGDRLPDTKMDRFLRKLGIDDRTPVPGYEKNEQLMKRLEKDGYLYKLKESTGTGEDDTFYVVGPRGRVEIGNNGVRGLVRAVMPPGDDEEEEADLDNKVLRSLGISDKPAAGGSGTQQNRGAAQTRGRRRKSAARDEEEQDEGADEQDEEDDDEEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKP3</accession>
    <name>N1QKP3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA repair protein RAD14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_149652</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPA family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759882.1">
        <property type="nucleotide sequence ID" value="XM_016905689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QKP3"/>
    <dbReference type="STRING" id="692275.N1QKP3"/>
    <dbReference type="GeneID" id="27902826"/>
    <dbReference type="eggNOG" id="KOG4017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053731_0_1_1"/>
    <dbReference type="OMA" id="VCHACKE"/>
    <dbReference type="OrthoDB" id="5368863at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901255">
        <property type="term" value="P:nucleotide-excision repair involved in interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000715">
        <property type="term" value="P:nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd21077">
        <property type="entry name" value="DBD_Rad14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.530.10:FF:000003">
        <property type="entry name" value="Dna repair rad14 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.530.10">
        <property type="entry name" value="XPA C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000465">
        <property type="entry name" value="XPA/RAD14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022656">
        <property type="entry name" value="XPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022658">
        <property type="entry name" value="XPA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037129">
        <property type="entry name" value="XPA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00598">
        <property type="entry name" value="rad14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05181">
        <property type="entry name" value="XPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00753">
        <property type="entry name" value="XPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="XPA C-terminal" evidence="12">
        <location>
            <begin position="220"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="323"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="339"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF11761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="373" mass="42265" checksum="FCF982B7D9E61CC5" modified="2013-06-26" version="1">MADTERPRTPPRRAPASAASAKSPITPEQVRRMEESRLRAKALRNQQDVRLAPSRPSPTSTTLAAGQKRPHAAITRDTPASSRDARNSVPSSNNGLASAPDDGIRAARKFQKYVEYDFSKMTDTKGGFMTADDDPYNKALHAPDPDGKPANMTLREWEHKQLQRKLQNAKAGPYEPGLSALDGRNAKKCRECGSLEIDWNWDEMLHTQVCHTCKEKLPEKYSLLTKTEAKEDYLLTDPELKDASLLPHIKKPNPHKSTWNDMMLFLRYQVEEYAFSDQKWGSAEGLDAEYQRRTQETKDRKEKKFRNKLNELKKRTRVDAYKKARSGGGGEFGDTIGKGQHEHEWGRSVEDPETGMTKKACVECGMEVEELEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>N1QLK9</accession>
    <name>N1QLK9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_129488</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764694.1">
        <property type="nucleotide sequence ID" value="XM_016902287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QLK9"/>
    <dbReference type="GeneID" id="27899424"/>
    <dbReference type="eggNOG" id="KOG0768">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_3_0_1"/>
    <dbReference type="OMA" id="DINYVHS"/>
    <dbReference type="OrthoDB" id="250329at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="75"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="190"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF16573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="354" mass="37596" checksum="EA6959B5CCF913C6" modified="2013-06-26" version="1">MRGTGNGDDDVDINYVHSPAYRTLYRNASNTAFTPALYRGLYQGVGSVIIATLPSSGAFFSTYEGIKTLFGDNGNAVVNAAAASGIAELVSCAILTPAEVLKQNAQMVNHDNVNTTLKNAKNAKNPSKNATLHTLQRFRSNPLALWRGYAALAGRNLPFTAMQFPLFEHIKTSIRRHRDDRGTRTNTLLESAIITAVSAGAGGSVAAVATTPVDVVKTRLMLSAIDHQPHSLHTAETTTTTTAAAAASTAAAAARQSVKQAKDAVVDATAHTIAAARQNPWEAWKGATSAAPGRKSSLTVAREVMQQEGVKGLFRGGALRAVWTMIGSGLYLGVYETGRIYLAQRRRVGDEAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1QLU3</accession>
    <name>N1QLU3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HIT-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_146285</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765303.1">
        <property type="nucleotide sequence ID" value="XM_016903551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QLU3"/>
    <dbReference type="STRING" id="692275.N1QLU3"/>
    <dbReference type="GeneID" id="27900688"/>
    <dbReference type="eggNOG" id="KOG3275">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056776_0_0_1"/>
    <dbReference type="OMA" id="EIGQWLP"/>
    <dbReference type="OrthoDB" id="1915375at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648:SF2">
        <property type="entry name" value="HIT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="HIT FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="4">
        <location>
            <begin position="30"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="2 3">
        <location>
            <begin position="139"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="1">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF17182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="208" mass="23362" checksum="88459E75AFDCA812" modified="2013-06-26" version="1">MSAIEELYPTPCAFCRISSAYPPESSDVPQSPDPERVDPQCHLILSAPLVLAFLDIMPISPGHILLTTRRHYRTLGDLPASKTNDTWVARRAAEEARDTSRALGEWLPIISRALCKVTGIEDWNVVQNNGERAAQVVPHIHFHLIPRYQEGRQEAQHSGRTDSALKSWKMFGRGSREDLDDDEARELANRLRDAIKTEVEIGSKTSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>N1QLZ6</accession>
    <name>N1QLZ6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">DNA replication complex GINS protein PSF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_35076</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.</text>
    </comment>
    <comment type="function">
        <text evidence="1">The GINS complex plays an essential role in the initiation of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the GINS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the GINS1/PSF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764984.1">
        <property type="nucleotide sequence ID" value="XM_016908593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QLZ6"/>
    <dbReference type="STRING" id="692275.N1QLZ6"/>
    <dbReference type="GeneID" id="27905730"/>
    <dbReference type="eggNOG" id="KOG3303">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079191_0_0_1"/>
    <dbReference type="OMA" id="MFCEKAT"/>
    <dbReference type="OrthoDB" id="1898560at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071162">
        <property type="term" value="C:CMG complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902983">
        <property type="term" value="P:DNA strand elongation involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd11710">
        <property type="entry name" value="GINS_A_psf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21696">
        <property type="entry name" value="GINS_B_Psf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1030:FF:000003">
        <property type="entry name" value="DNA replication complex GINS protein PSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005339">
        <property type="entry name" value="GINS_Psf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056783">
        <property type="entry name" value="PSF1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914:SF2">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914">
        <property type="entry name" value="PARTNER OF SLD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24997">
        <property type="entry name" value="PSF1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GINS subunit" evidence="9">
        <location>
            <begin position="65"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="DNA replication complex GINS protein PSF1 C-terminal" evidence="10">
        <location>
            <begin position="184"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF16863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="233" mass="26372" checksum="7C277AA4BEE2337F" modified="2013-06-26" version="1">MYAEQALKLVHDARRTENLPHLPPYNTTVIRAVTKEVRDLDREINTLLAPFAINNTNNSNTARSSTTTTSSFNPHEHPQLACTLLVNQLSMRRNKRCLLAYHRTRTEKLEGFCWEGRDVNINNNQNQNINNNTISETMTTTTTTTSTLSSEEEQYTHAYSSLLAAYKGQWTEIDLTGSVEPPQDIFIDVRVLKDAGEIQTEYGSITLTKNSQFYVRAGDVEGLVRQGYLQKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>N1QML4</accession>
    <name>N1QML4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_153230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765334.1">
        <property type="nucleotide sequence ID" value="XM_016907505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QML4"/>
    <dbReference type="STRING" id="692275.N1QML4"/>
    <dbReference type="GeneID" id="27904642"/>
    <dbReference type="HOGENOM" id="CLU_1741719_0_0_1"/>
    <dbReference type="OrthoDB" id="5356111at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF17213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="150" mass="16758" checksum="B1AF1104579FE49D" modified="2013-06-26" version="1">MPGELRLLRSSIEERDNDWPQRDAIVECHSAIPITSPRPHDRPGLWYSIGMYPYRSRGRTPVADRPHCRHSRLLLLAGAIASSENQQHPPDPAPPSLSAGAHETRDYYAAQTVPRPLSPNEPCLTPSSVFERDSRRCGYTTGSCCPDMQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNH9</accession>
    <name>N1QNH9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mitochondrial large ribosomal subunit protein L16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_58526</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765894.1">
        <property type="nucleotide sequence ID" value="XM_016909469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNH9"/>
    <dbReference type="STRING" id="692275.N1QNH9"/>
    <dbReference type="GeneID" id="27906606"/>
    <dbReference type="eggNOG" id="KOG3422">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078858_1_0_1"/>
    <dbReference type="OMA" id="MPGMYEF"/>
    <dbReference type="OrthoDB" id="268521at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.10:FF:000003">
        <property type="entry name" value="54S ribosomal protein L16, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="entry name" value="Ribosomal protein L10e/L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047873">
        <property type="entry name" value="Ribosomal_uL16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000114">
        <property type="entry name" value="Ribosomal_uL16_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020798">
        <property type="entry name" value="Ribosomal_uL16_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_uL16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_uL16_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01164">
        <property type="entry name" value="rplP_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220:SF13">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL16M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00060">
        <property type="entry name" value="RIBOSOMALL16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="Ribosomal protein L16p/L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00701">
        <property type="entry name" value="RIBOSOMAL_L16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="210"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF17773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="236" mass="26043" checksum="2BB2702168B8EF45" modified="2013-06-26" version="1">MRVGTSSSSSISAPTSLLSSLFTTRACCIHSALQAPTQRHFSSTPRPLNWLIPKAGETTKSRKGRPQCPTGGSTKGTTLVWGSYGIRLKDTDRRISASQLKIADETIKKRLRGFKYRLYHRVSAGVGVYTSGNDQRMGKGKGTFDYWAARVPVSRILFELEGTIHEQIVRDAFRLAGNKLPGQYEFVRKGDPPVMGITKLGEGVTEDMLRRPRRQVPAPGPNMVKQAERMPATTPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M3ASG7</accession>
    <name>M3ASG7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">DNA replication complex GINS protein PSF2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_166870</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The GINS complex plays an essential role in the initiation of DNA replication. Has a role in chromosome segregation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the GINS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GINS2/PSF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756555.1">
        <property type="nucleotide sequence ID" value="XM_016908267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3ASG7"/>
    <dbReference type="STRING" id="692275.M3ASG7"/>
    <dbReference type="GeneID" id="27905404"/>
    <dbReference type="eggNOG" id="KOG4071">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078274_0_0_1"/>
    <dbReference type="OMA" id="DSLNCMY"/>
    <dbReference type="OrthoDB" id="1938138at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11712">
        <property type="entry name" value="GINS_A_psf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21694">
        <property type="entry name" value="GINS_B_Psf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1020:FF:000001">
        <property type="entry name" value="DNA replication complex GINS protein PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.5.50:FF:000001">
        <property type="entry name" value="DNA replication complex GINS protein PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007257">
        <property type="entry name" value="GINS_Psf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056784">
        <property type="entry name" value="PSF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12772">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12772:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25005">
        <property type="entry name" value="PSF2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028998">
        <property type="entry name" value="GINS_Psf2_subgr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160059">
        <property type="entry name" value="PriA/YqbF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4 8" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication complex GINS protein PSF2 N-terminal" evidence="11">
        <location>
            <begin position="10"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="GINS subunit" evidence="10">
        <location>
            <begin position="145"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="93"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="232"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR028998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF08434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="267" mass="29187" checksum="3AE96C2B1D3DD0DF" modified="2013-05-01" version="1">MALPLPPGLTPNEVGFLCEMELVTVIPRQRLEGLELLGGPTDRLNPPFPTQLPLWLALLLKRQKRANISPPPWLSPTSLQSLLDLETDPILAGALAPGPDLPPAPPTAQTSNSSNEPPNLLYLDPPSSTWQTRSPPFLPDSNTKRAQPDALPYHWNELGFLLLTHASEDFAEPDVTRRLLRDLREVRMSKLRKGFKALEAGAGLKVNGVGAMEVAEIRGFVGGVVDGLRRLNASREDSQREAEGDDDQDALGGSSSYYQDDDDTMDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M3ATM5</accession>
    <name>M3ATM5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Calcofluor white hypersensitive protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_151773</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756985.1">
        <property type="nucleotide sequence ID" value="XM_016907037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3ATM5"/>
    <dbReference type="STRING" id="692275.M3ATM5"/>
    <dbReference type="GeneID" id="27904174"/>
    <dbReference type="eggNOG" id="KOG3979">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009808_0_0_1"/>
    <dbReference type="OMA" id="CVWYFPL"/>
    <dbReference type="OrthoDB" id="68581at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000031">
        <property type="entry name" value="Calcofluor white hypersensitive protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057315">
        <property type="entry name" value="Exo_endo_phos_PGAP2IP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051916">
        <property type="entry name" value="GPI-anchor_lipid_remodeler"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053912">
        <property type="entry name" value="PGAP2IP_TM_1nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053911">
        <property type="entry name" value="PGAP2IP_TM_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14859">
        <property type="entry name" value="CALCOFLUOR WHITE HYPERSENSITIVE PROTEIN PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14859:SF1">
        <property type="entry name" value="PGAP2-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23022">
        <property type="entry name" value="6TM_1st_PGAP2IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23021">
        <property type="entry name" value="6TM_2nd_PGAP2IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23226">
        <property type="entry name" value="Exo_endo_phos_PGAP2IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="459"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="496"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="525"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="547"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="577"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="612"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="654"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="2">
        <location>
            <begin position="17"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="PGAP2IP first transmembrane" evidence="4">
        <location>
            <begin position="281"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="PGAP2IP second transmembrane" evidence="3">
        <location>
            <begin position="456"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="PGAP2IP C-terminal nuclease-like" evidence="5">
        <location>
            <begin position="687"/>
            <end position="925"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF08864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="952" mass="106743" checksum="A1685DD5EBA6B0EF" modified="2013-05-01" version="1">MAPKHRDGDVVASIPGSFISHAHTIAAYAAFLSAFIVGVYLHYHKIVQNEHYGYPVEWFPSVSATIGDRYPERSFFMVFIAICSGPRFALCFLWWCLGKKPNGGNRLVNFVAGVGVFRTLTCGGWTYVTSTDDHDWHDIFMISYLVATLPWTIGCIALSPPNPQAIKLRKYLGGTFFATLVPLVYFFIQHKVHRVPGAYTIYAFFEWSLVLLDVAFDAVTAYDFSSFEIQIRDVKGLSKGGNVADRTLEKRKDKPIGTVFDASAFTWDEMFDAIADVYLGYIFWTVLTSLGVVVWYFPLWHMGISGYEVAVMSTVSPMLLGIPSLRRLVTRNSPLVILTSGAGLLAYLVVNPPQRLGMVSFGVWQGTLAWVALWWSKRNQPAMLEAKISAWLLGLIASSISKFAFWTNNPLWPIMHDANGGLNKTGIVLFVLAVARAYQKQGKNIGSERNQEKPKGPSFLAGLGLAGAFFGLHSLLSDSSTMILWVWEGFPVRGPLASPHGAWTIGAMGLGLLIGLWYPNIARSWAAFGVGSVGAAILTLRTHWTGYYGGLTLATYLMAVTPSLITNAVRFAPGRTFFVGFFFYNFMVLFHVWVVAYAFVPGGPLVRERTDWVMLTTMLMIGAGVFSSIHNGAPVKQKSFQPPPNPAAKRQRSYYIYALLALQLVSVSVAYLRFPTYNYQPYHKDSKLITAGIWTIHFSIDNDMWSSERRMESLIRETELDVIGLLESDLQRIIMGNRDTTQYLAEELGMYVDYGPGPNKHTWGSALLSKFPIVNSTHHLLPSPVGELAPAIHATIDAYGELVDVFVFHSGQEEDPEDRRLQSEYLSDLMGSTNRPSILLSYLVTKPKEGNYNTYVSDRSGMKDIDPSDWDRWCEYILYKNMRRTGYARVSRSTITDTELQIGKFVVGQAEGTNELIPEEQVPEPLRFPQMFRGQGVRDHRYHVFDEPRYYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M3AWA4</accession>
    <name>M3AWA4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TPR-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_157162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759141.1">
        <property type="nucleotide sequence ID" value="XM_016907722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AWA4"/>
    <dbReference type="STRING" id="692275.M3AWA4"/>
    <dbReference type="GeneID" id="27904859"/>
    <dbReference type="eggNOG" id="KOG2796">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022275_0_0_1"/>
    <dbReference type="OMA" id="QDPQAYH"/>
    <dbReference type="OrthoDB" id="428342at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21581">
        <property type="entry name" value="D-ALANYL-D-ALANINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21581:SF6">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF11020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="455" mass="49902" checksum="5F306B4E9D3A70EB" modified="2013-05-01" version="1">MQSPGSPSGSVRRHARNISHPIPQRAARGPLETATHDPLADAPTTTTTTTTSSSSSSTIPDVSSSIVHPQDSTPPPSQKHALEPEPEPEPQLELEPAVATQPRANVDLRFLQDRKIYHSVTAEDIPSPFLNSTHRPPVEASLTDLLSGGHFRRAAEAALRAILQSPPTAAERIFPLLYIRLACLVLIQRSDIAAAEALSLVELSSRNIPGAQDIIDLVPWELRLLLVRLQSIRAADGGRRGIMALYALAGEVKSNLRLARKDHDDFQIDLWNNRLSEVGLRVCDALAEMGELETAARHLETLTEANTDEVAYRKVLLQIRLGDVSGASRYAQTLQDHAKREGLEALLQVADGNHEDAVAKWRALMDQYPDHDHFALNAAVSLLYTGHIAAARDLLEDLARTRLISPTLLFNLSTVYELCTERAPEKKTALIQQVAARRPSPAHGGWEHAAFDFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M3AWW9</accession>
    <name>M3AWW9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Salicylate hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_126802</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759341.1">
        <property type="nucleotide sequence ID" value="XM_016902103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AWW9"/>
    <dbReference type="STRING" id="692275.M3AWW9"/>
    <dbReference type="GeneID" id="27899240"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_6_3_1"/>
    <dbReference type="OMA" id="LDRPTSW"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000153">
        <property type="entry name" value="Salicylate hydroxylase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="7"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF11220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="430" mass="47520" checksum="EE10A2609FB05F1F" modified="2013-05-01" version="1">MPTKKNFQVAIVGGGISGLTLGIALHSRGIPVTIYEQAPHFAEIGAGVAFTGNAVQAMKHCNQGIYEAFEKVRTKNMWPSKEKVWFDYHDGYHRKADQKDTHAFTITNSIGQAGVHRAHYLDELIKLFPSEQAQFGKRLERLDKGDDGKWTLKFEDGSSATADAVIGCDGIKSSVRRMLYGENDPRSFPTYTHKYAYRALADMDEAVAAVGEEKAKNSCMHMGPGGHMLTFPVNHGKTLNIVAFHTSPDDWPDYSKLTRSATREDALRDFSGYGQDVIRLLQLCKPNLDVWAIFHLGDHPLPYFAKGTICLVGDAAHATSPHHGAGAGMCIEDSAVLADLLADENVKSHKDLEAAFAIFDEQRRDRGHFLVQTSAFIGNSYEWLADGVGEDFSKIEHEINVRNAKIANVDVPQMCREATAKLQGKIQSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M3AXP1</accession>
    <name>M3AXP1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="5">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_150419</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DNA polymerase type-B-like family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="5"/>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759626.1">
        <property type="nucleotide sequence ID" value="XM_016906162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AXP1"/>
    <dbReference type="STRING" id="692275.M3AXP1"/>
    <dbReference type="GeneID" id="27903299"/>
    <dbReference type="eggNOG" id="KOG2277">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016776_0_0_1"/>
    <dbReference type="OMA" id="NTHMLRC"/>
    <dbReference type="OrthoDB" id="407432at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050265">
        <property type="term" value="F:RNA uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF40">
        <property type="entry name" value="POLY(A) RNA POLYMERASE GLD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="12">
        <location>
            <begin position="3"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="11">
        <location>
            <begin position="369"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="521"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="217"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="549"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF11505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="632" mass="70384" checksum="561E36B5B464BCD3" modified="2013-05-01" version="1">MSQSERDEKDELRLALQKVCQQVCASNPNLPKVSLECFGSFQSGFASAGSDMDLVIVVQDQGPADAIFSMLEDGLPRSLEKELLRAGFGARLLTRTRVPIIKICQSPGGSLLDKLREEREKWDSLPHEQKYPHLYKEDDTQVGENALVQGEDGIVSIPQPGPEPTASPAAHVTVPTTTALHGELSAPVQVASVDGVTHGAKSVDEVDIHNNSHPVQARRDQQKSWTRERKAGPLDFPKDGIGIQCDINFSNPLGLHNTQMLRCYSKCDPRVRPIVLFMKSWAKQRKINSSYSGTLSSYGYVLMVLHYLINVVRPPVLPNLQMQWRPHTHCTPPGRTRMEVDGWVVDFWRNENEIESALRNGQMSANSDSIGSLLAGLFQYYSSMGNGPQFRWTQQVLSLRTPGGVLTKGAKGWVKATTEEGEGKRIQHRYLFCIEDPFEHSHNVARTVTHNGIVAIRDEFRRAYRILNAVAQNDQLNGAQGPPSPEGDLFDKLLEDDEEMIEVEKRDMEILGVNKIVREDEGDVADQKDPRHGSASTRRKNGKRDNSQQRKNGLPLSQPNKQLDVADQEAFPSLGAAKGSSRRKKSSSASNFNEISGNQAQEYLEEFRRKKVEEQAERTAYGAAESVLNGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M3B354</accession>
    <name>M3B354_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_106581</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016900645.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="27897782"/>
    <dbReference type="HOGENOM" id="CLU_1908005_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032008" evidence="2">
        <location>
            <begin position="25"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF14232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="133" mass="14550" checksum="BC64FEE0A6F2D3D6" modified="2013-05-01" version="1">MPLMMMMMMLLLLLLLTMDVLMEAGKGGMKVMQRAKLVGKLVRESERRGAGIVVITKYELIDALVFVASAAIDERESCRQAHQTAPVCHRARPVLCKSHKPLANTLATVLLAIFVTALAPALVVFAAHAKLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M3B3W9</accession>
    <name>M3B3W9_SPHMS</name>
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        <recommendedName>
            <fullName evidence="10">Deacetylase complex subunit Sds3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_132109</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762573.1">
        <property type="nucleotide sequence ID" value="XM_016902472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B3W9"/>
    <dbReference type="STRING" id="692275.M3B3W9"/>
    <dbReference type="GeneID" id="27899609"/>
    <dbReference type="eggNOG" id="ENOG502S0G7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031130_0_0_1"/>
    <dbReference type="OMA" id="NQHQHYR"/>
    <dbReference type="OrthoDB" id="70376at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013907">
        <property type="entry name" value="Sds3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21964">
        <property type="entry name" value="BREAST CANCER METASTASIS-SUPPRESSOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08598">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01401">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="238"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="328"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="413"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="545"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="139"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="547"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="562"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF14452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="605" mass="65708" checksum="B7508CD4603D2611" modified="2013-05-01" version="1">MAINHQDASIFDGSASPQPQPLTKRDVRRNRIMDKLFAMQAGFAANQNQHYRAQLQGVQVDMTLVLRADPYRNDGPLEDSHEGIRELVEQVMQSDNQGRGVALFDDDNVKTDFWATAGKRYGEFAREVNDSIERRDADLTMLHNNYDAALQELDRLHQQRLRQAEEEHRELSNTIRQRLIATLNKKRQQLLRDKDQIDISDSNAMLLHPNHFSIGNNVASPSQNGVGVGKRTRYLRHHRAASPGPAGTEAENGKRKRKLGQAEDDTGNESPIPNYGGRSPFKEAKGTREYAQFEAPAYSLERLFTEKELALATDLAKKATYKYFYQKEQEPSSNSNGTAVPSVDGEVVEPGDAQGDEAMAGAHGTNTPPPSEPPAAVGMERQASHQVLTRGGAKANPLAALSDLANAAAAASSTEPVIRRNPFTPEQPSFHATSRAEKSGAPAPAPVSNLDMENDFQMMHDAGADYHTADPDGDVEMDHQLAADEAKDLRRRLLDQALGVAGVQAPYRLPQLEPGPGALIGRGVDREPRTGFAPVQPVVVRIESRLKTTNPSTDITNGASGGSMAAALSGRLGAEPMSRTTSAGGTSELGEPSTSRGRGGRGRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M3B5I7</accession>
    <name>M3B5I7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lactonohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_138815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763168.1">
        <property type="nucleotide sequence ID" value="XM_016902888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B5I7"/>
    <dbReference type="STRING" id="692275.M3B5I7"/>
    <dbReference type="GeneID" id="27900025"/>
    <dbReference type="eggNOG" id="ENOG502RZSA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036110_1_0_1"/>
    <dbReference type="OMA" id="WQAFHEA"/>
    <dbReference type="OrthoDB" id="423498at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052988">
        <property type="entry name" value="Oryzine_lactonohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47064">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G08990)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47064:SF2">
        <property type="entry name" value="SMP-30_GLUCONOLACTONASE_LRE-LIKE REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="1">
        <location>
            <begin position="129"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF15047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="365" mass="40290" checksum="34EDB83A806C3E07" modified="2013-05-01" version="1">MVNITHVNLLRLATSLDYANSLHAITNASIDHVSLLSYDPSFLDILGSNVTQRLVAEFPWQAFHEAGAYNLATQKIYATSNWAGDISNPINITIIDPTTNEISSRRYPNLTNANGGTVYYPPGTPLTSTTNQALVFCDQGDLTHASQLTLVDPATNTTRVLLNSYLGKNFSSINDVVQHPLTGDLWFTDARYAFWQHFGREPQIRPQVYRFEPETGVVQVVADGFVAPNGIELSPDYKHIYVTDTGVHTFAGKDNATDPANIYKFDITPDGKRLENRQVFAYSERGFPDGIHTDTEGNVYSAMSDGVHVWNPSGILIGKFGVAGRGSANFAFVPNGMYIQNELKLWFISIAAEGRTMRRDFGLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M3B6V9</accession>
    <name>M3B6V9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DUF1640-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_80391</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763673.1">
        <property type="nucleotide sequence ID" value="XM_016910242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B6V9"/>
    <dbReference type="STRING" id="692275.M3B6V9"/>
    <dbReference type="GeneID" id="27907379"/>
    <dbReference type="eggNOG" id="ENOG502S831">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030970_1_1_1"/>
    <dbReference type="OMA" id="MMHEREM"/>
    <dbReference type="OrthoDB" id="5424147at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024461">
        <property type="entry name" value="CCDC90-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360:SF12">
        <property type="entry name" value="MOZ PROTEIN REPRESENTS A CHROMATIN-ASSOCIATED ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360">
        <property type="entry name" value="PROTEIN FMP32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07798">
        <property type="entry name" value="CCDC90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="36"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="403"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="63"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="169"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF15552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="440" mass="48430" checksum="F08A781DE6833585" modified="2013-05-01" version="1">MAAPRLPFLWPMLAKGFEANAPSARAAKAAVRFRALHSSARRRSPETTVPQKQRYGAANEPPPHLRSETPPTKEDLEAQQKALPKIGKRLQNAGEAEIKAEKEEGQDEGVEDVPAKGEEAVQSKSPLAATLDAAAPVPKAPGSLDTPPDKPMETLLDQVPDPQAHSEKQQQTTAKQDSPSSNHISDKGGPVVDEHAPPTKAPHISTPRHVHHFDTYSLVNRLKAGNWTEAQAITAMKGVRVMLAENMDLAREALVSKSQVENETYLFRAACAELKTEVTSRRRAEQEKLRTERAQLQHEVEILNQRLGQEVAAMKDDVKGTFDDRKMAVRNDERLMESKIQRLNYQITVDLQADAKSEVEGLRWVMTRRVILALGAIVIMVVGSLRLYSNAVHEQEMKAKRLANMRSGSTQTESGAEHGRPSGSDNMSEGEMLVDSLPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M3B8J0</accession>
    <name>M3B8J0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">asparagine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_81672</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="2"/>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF16172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764293.1">
        <property type="nucleotide sequence ID" value="XM_016910283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B8J0"/>
    <dbReference type="STRING" id="692275.M3B8J0"/>
    <dbReference type="GeneID" id="27907420"/>
    <dbReference type="eggNOG" id="KOG0554">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004553_2_0_1"/>
    <dbReference type="OMA" id="PEMAFYD"/>
    <dbReference type="OrthoDB" id="43906at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070145">
        <property type="term" value="P:mitochondrial asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04318">
        <property type="entry name" value="EcAsnRS_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF34">
        <property type="entry name" value="ASPARAGINE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="9">
        <location>
            <begin position="173"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF16172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="531" mass="59478" checksum="78AE8228903BB630" modified="2013-05-01" version="1">MTVWRSASCAVRRLEAACRCPRRPFTTSSSYASYDPQRRDAIVDLLNYDSDHPDAVDKIEQDVRVSGWVRSVRKQKQVAFAHIGDGTTARPLQAVLKPEQAANLSYGTAVTLNGAWTPSQGKGQNRELQVTSVEVRGENHADSNPVQPKYQTPEFLRTVPHLRPRIPSNALLLRLRSHLISTFTKWFDGLDFVQTHTPIITSSDCEGAGEVFTVSSNDSKRSGQKTPPQPQHASQVEHFFRSPKYLTVSAQLHLEALAQAVDRVWTLSPTFRAEKSDTPRHLSEFYMLEAEVCFATDMKQIMDLLEVMLRNVTGYISVSRVGQELMEARKSPKDPQREGDYAVSATTLDKRWLRLMRANWPRVTYHYAIKRLQAAVADKQVKFAFKPTIEGGLQAEHERWIATTLGNGAPVFVTDYPRSQKPFYMSPSTSTANSKGTNDTVACFDLLVPDLGELAGGSMREYRSQELVNAMKAKGLAGTGSLEWYQDLRKYGSVPHGGFGLGFDRLLCYLSGINSVRDVVAFPRWHGRCDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M3BTL6</accession>
    <name>M3BTL6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha-taxilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_151058</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the taxilin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF09980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758101.1">
        <property type="nucleotide sequence ID" value="XM_016906567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BTL6"/>
    <dbReference type="STRING" id="692275.M3BTL6"/>
    <dbReference type="GeneID" id="27903704"/>
    <dbReference type="eggNOG" id="KOG1850">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029275_0_0_1"/>
    <dbReference type="OMA" id="CTPPECV"/>
    <dbReference type="OrthoDB" id="425555at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026183">
        <property type="entry name" value="Taxilin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16127:SF13">
        <property type="entry name" value="GH01188P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16127">
        <property type="entry name" value="TAXILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09728">
        <property type="entry name" value="Taxilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="55"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="475"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="400"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="489"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="577"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF09980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="588" mass="67183" checksum="D0A813EFEAE07ACA" modified="2013-05-01" version="1">MASTLNTAQILAQKKKTDKYEAARTGARNSKDSVVETYTKGERFIKYQESVMNAVAQQQHQAQPAPQSAHRSSPSIPHDFARDAPVSATADSTFATPPPPPAAAPLPAGKGKAKGKKGSLSSANPSDAHAALLSKISQLESTNAEDAHQNAEIEAEVKKANRDLSQLLNTMEPHHSKMDILQKKYSDLLAEMKRTEREHVKAKKRGDQLQKEKEEVGKERTRERGLKEKLEKLSRELTRENKKLKDDFRELKENAANRNDELHRKLENLVIDVEEVVCEKRSPERQAAELEQDRLFREKFTSFLHQYELRELHFQSLLRVKELEIQYQIARHDQLKKAQESELSKSHQLTRQVSTFSQTENELRGQLNVYVEKFKQVCQDFYHHQHAKVEDTLNNSNDLFLTFRKEMEEMSKKTKRLEKENLNLTRKQEATNKNIFQMAEERSQSQQTIDRLTRENEKLKKLCRAMQTGGYGNAQQMAQQGAHVGQGADEFDEGIDGETESEYEDDEEYDEDEGEYDDDTEEEPEDEQTRVYGPPPPPPPQTEVIKPNGQIHRVTEGEQRAMMAPAHRAALDAQAKQAVQVNGNGQRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M3BTX3</accession>
    <name>M3BTX3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_151145</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758226.1">
        <property type="nucleotide sequence ID" value="XM_016906630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BTX3"/>
    <dbReference type="STRING" id="692275.M3BTX3"/>
    <dbReference type="GeneID" id="27903767"/>
    <dbReference type="eggNOG" id="KOG4569">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032957_3_1_1"/>
    <dbReference type="OMA" id="HAGEVYI"/>
    <dbReference type="OrthoDB" id="438440at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051299">
        <property type="entry name" value="AB_hydrolase_lip/est"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46640:SF1">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46640">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032077" evidence="3">
        <location>
            <begin position="19"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="4">
        <location>
            <begin position="109"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF10105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="375" mass="41431" checksum="CE2184FC8FAE65C7" modified="2013-05-01" version="1">MRCSHLLLNVLGALGCFAHDRQQQLPLLQHADNRNVSAALFAELEELARVVDIAYCVGSTSWGISKPFSCLSRCSDFPSFELITTWNTGPLLSDSCGYIALDHDKRRVVVAFRGTYSISNAVVDLSTVPQKYVPYPGEDDGDEPSFRVAGQPKCMNCTVHMGFHSSWLNTRKQILPDLQAQLSAHSDYQLTLVGHSLGGAVAALAGLDLLARGYHPVITTFGEPRSGNVGLAKYIDERFNLTTNVPVDDTQTNYRRLTHIDDPVPQLPLTEWGYAMHAGEIYISKSDLSPDIVDLQHCKGDNDKDCIAGQDSTLLASVKDEIYDITTEPWGIPSRYKLWQLLFAHRDYFWRLGLCVPGGDPLGGGGKYKFVHGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M3BU32</accession>
    <name>M3BU32_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_135517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758296.1">
        <property type="nucleotide sequence ID" value="XM_016902718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BU32"/>
    <dbReference type="GeneID" id="27899855"/>
    <dbReference type="HOGENOM" id="CLU_319621_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="741"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="865"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="743"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="774"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="882"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="900"/>
            <end position="909"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF10175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="909" mass="99142" checksum="B0ED45CD2096CDEB" modified="2013-05-01" version="1">MDEQDGTQQDAASTSEPQYEAFMSIIEDIQSSEPQSRSAMSEAEEAVIHHNSVPSSPNPKNDIEPLQPQQQYSSLCPYPTPDASRASSPLFQKEEDLCDSTPPPLRKNNKMPSELPDQPYPPPLGIQQTHSPLTSLHRDRYSPYDPLSYVLQDPIQVWAIRLTPKRTQYEVESSSPESLALDDDDDNNEAITPTRAAGGRCMKNLQPLEDIGRRVRVSNFRGKELLSGLEEEARKMKGKMPDWEGLNQERREEASGWEKVDLVGPERATKSAGGTIQSRSRDISEPLRKVMATTTIPEGKPLSVHSSGQGRPPGSNVEIVIEGERLRPDQIPFSLTQLGTRLRTGISSIVFLAPAPDKPGPIKRALVTRNSVACSQERNCRNKVRSENGMAAVLEPNRKTQLTGGNCEIEGSGAAESGKDKQQNECRAATVAASRHEALMLKAGDLQAPETTAVAQSGSALQRRVDVIRHEQTRERMHAKACTSIDNPALHTPRAADAACQADLVPWPCATANCKRPSEKSLVRLCNVERAKVLNNRNLAHSGTRLVADGSSFCWECRLKKSRQRKTLRRKRAANLNEVSCGKENEERTLSKKRKLVDAAAMLGEDEVTSPAKRCCTAEVCEKYGPDSRAPVDQNAASVEQDDSAMVAQDPDVVHQTAKVNPGCIFSGAFAEELEAVSLQPASPCTELLLTRPICSLNASFQPPEAVAVAIPSDCQTRVVAAGGTYTAQRRVPLADITARLVPHSSPPRSSSVKYGSHTPSPLRSVQAAEATPPTSPLPISPMSPTPARGYDVLSSSKNAIKSVSSRTIVEHHSRAVADGTSSLCSLCGQFLACDAHELGISCANPLISGQKRYAAKKARRKSLQWTRRQKAESVQEENDYADAHASSKDTRLLPDDKRKPLKGILKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>M3BV67</accession>
    <name>M3BV67_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal_trans-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_164767</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759340.1">
        <property type="nucleotide sequence ID" value="XM_016908132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BV67"/>
    <dbReference type="STRING" id="692275.M3BV67"/>
    <dbReference type="GeneID" id="27905269"/>
    <dbReference type="eggNOG" id="ENOG502S0D7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008511_1_1_1"/>
    <dbReference type="OMA" id="CFWEFIH"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF3">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="39"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="116"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="675"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF11219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="784" mass="87472" checksum="4A4DDB28C12729B6" modified="2013-05-01" version="1">MEGQAPDQMMQGGQHAFRAADGSQPDLPKSTKRQRVSQACGPCRDRKTRCDGRQPICRACETRGVTKSCNFDYVRRQRQPRASGASVGHSPQSDSLRHIRELGSDPRNHAAAQALSDLGQQPREVVAPASMSTTSTVRPSDSAPSAPSVAGQYQPTWSTTSRADGLATLADGSDGSIYGPSSAVAFLRHVMPHKSGTATPVEPSLLDPDVKPRPSVPLPDRHLPRSHGLAVLPRRREADNFLLCYWEFIHPLFPVLHRPAFLRKYESLWIDTDDNNNKANESEVEDAIFTSTLNLVFAIGCKFSSIIEAAQKSTVAEDFFQRSRQSYAFDILDSTSIAVVQMLVLTGVYLQSTQHASRCWNSIGLAIRMAQSIGLHVNHSGRQQMSQVEQQMRRRIWHTCIHLDRLLSMTFGRPAMIEKQIDVPAPALIDDEYLADRGVGSQATGVLSRLGMFIYSSPLMELLEEILERFYRHSSLSQNRSSFPETTDIVTPVLVINRKLDDFAETVPDYLRVSNNSSTPGRNEDHILLQQQVLHNRFLFIRMLSLRPVLLAATKRGSRPLTKYSLDDDVIRSCCTRCVLTASRLVDGIHDTFYTLYRSSGWHSVYFTFSAAMTLLASWKIDHLFSGPEGDTRETTWSRCLVILEYYENQIHSAEHAIKILKSLKLQITSRAQASTVTQESPTQLDPTLRPTPNTEGATSTTADLYSTLSMDESDLFGTDNISEAWYGQQLINLDWLEIPQLLARPDFEFFKDSTAASWSSTIKSGCPASTPTWLSHPLPVILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M3BXY6</accession>
    <name>M3BXY6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD-specific glutamate dehydrogenase</fullName>
            <ecNumber evidence="4">1.4.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_149456</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">NAD(+)-dependent glutamate dehydrogenase which degrades glutamate to ammonia and alpha-ketoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-glutamate + NAD(+) + H2O = 2-oxoglutarate + NH4(+) + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15133"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.4.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.2" evidence="4"/>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761042.1">
        <property type="nucleotide sequence ID" value="XM_016905563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BXY6"/>
    <dbReference type="STRING" id="692275.M3BXY6"/>
    <dbReference type="GeneID" id="27902700"/>
    <dbReference type="eggNOG" id="KOG2250">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005220_0_0_1"/>
    <dbReference type="OMA" id="DEYGMTS"/>
    <dbReference type="OrthoDB" id="184415at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004352">
        <property type="term" value="F:glutamate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006538">
        <property type="term" value="P:L-glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056365">
        <property type="entry name" value="NAD-GDH_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016210">
        <property type="entry name" value="NAD-GDH_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055480">
        <property type="entry name" value="NAD-GDH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606">
        <property type="entry name" value="GLUTAMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606:SF24">
        <property type="entry name" value="NAD-SPECIFIC GLUTAMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23147">
        <property type="entry name" value="GDH2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23152">
        <property type="entry name" value="GDH_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000184">
        <property type="entry name" value="GDH_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal" evidence="6">
        <location>
            <begin position="701"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF12921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1069" mass="119835" checksum="CBECD68DAC20ED85" modified="2013-05-01" version="1">MATAPAAHRDHGVNGVNASTSSPHNKLLDNVAMTPGRQPSPQPTHLSVPGSIPHRVVHDRGSGYVAPKFEGKEHQMEQVMDAVEDKGFIPVDVGEMETKWFYNELGIDDMYFSTESVDAIVSHIHSLYAAKIAAFARDDRKLEIRLEKEAADHAVYIDTSVPGLSTLDGSGFETRLESKYLDGSRGLNSYRVESFRSPSTMPGGNNDQSLRCYFVYQATFKNRTPSPNETNIEELGDERFLQKTTANTREIYQSVMDAIVLRTGPVIDMYDVEGTREKRLVVGFRQGSALGLFAALSHLYHYYGLTSSRKYVEQFSNGITIISIYLRPGPTAVSAKHPPIEASIHQVMKETSLLYCIPQNRFQTHFSSGRLSLQESVYAHCVWVFVQHFLNRLGGEYNTLKSLLDTSNSVHAELLGKLKKRLRTETFTADYILEIINQYPDLIRSLYLAFANAHYVQTRGEQDDFLPTLSYLRMKVDKVYTDDELGALIEKTVSNDHHNMVMTAFRIFNKSVLKTNFYTPTKVALSFRLNPSFLPLEEYPQPLYGMFLVVSSEFRGFHLRFRDIARGGIRIVKSRSKEAYAINARSLFDENYNLANTQQRKNKDIPEGGSKGVVLLDMAHQDKTTVAFEKYIDSIMDLLLPPTSPGIKDPIVDLHGKEEILFMGPDENTADLVNWATEHARIRGAPWWKSFFTGKSPKLGGIPHDSYGMTTLSVREYVKGIYRKLELDETQVRKLQTGGPDGDLGSNEILLGNEKYCGIVDGSGVLYDPQGLDRTELLRLAKERKMISHYDASKLSKEGYRVLVDDNSITLPSGEVVNNGTSFRNTYHLRSQEKFDCFVPCGGRPESIDFPSASKLIANGKATIPYIVEGANLFITQEAKLRLEKAGAIVFKDASANKGGVTSSSLEVLAALSFDDESFLQHMCIQADGSAPQFYQDYVREVQAKIQENARLEFEAIWRESEQTGLAKSLLSDQLSLAITKMDEELQGTELWNNVALRRSVLCDALPNLLLKKIGLDKIIERVPDNYLRAIFGSYLASRFVYTMGISASPVSFFAFMNDRMAKVNGITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M3BYV2</accession>
    <name>M3BYV2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_155618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761377.1">
        <property type="nucleotide sequence ID" value="XM_016907626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BYV2"/>
    <dbReference type="GeneID" id="27904763"/>
    <dbReference type="HOGENOM" id="CLU_1866380_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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            <strain evidence="2 3">SO2202</strain>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="610" mass="67414" checksum="3A8B7909D1AAAD3B" modified="2013-05-01" version="1">MIETWEDRERKHALVNQIRAACLAQQQQASVHKGKPRSEAPFLSRIDIHHEIESVRDRAAAQQIGQKGDLQVLVVDRPYPACGKSLVELDCWLQIKDLLLETRHVDKVLVVRRFGPVATSPVGGTYGVEDETGTCELLLVDAFSFAGDQVIPVDAVVAIKEPYCKVDGSGKPRIKLSHPTDLMILPPDHSKIPFKWRMDGPVVSNSTDPLGSSSTNANCCSESLNDISATKVNDMERAGRGLFAQKAFKFGDKIMSEEATFFLSPNEDCAFRALKYDLSKNMMTEDIGAPYKELANALSQDRDMAIKVFNLHSGPVDMPCSGPCLIDGKPVIDIFHIHEIWCNNAIACPANLQPKAFPNRVSADSPSASGLWCHFAYCNHSCLPNAEKSFKDGVLTLRATRDIDEGEEITISYGEYIDQTEKLQAMHRIWGFKCECRVCAAESQTSKEMLAHRETLRTKVSAPLPTTLTADLITEAKALASEIQTTYPDTSYAPNLPRTAVAEAYSRLFTIHSKLLNLNAAEDALRKMLHALAVLDIIEAKVIPLGGVLGEMTVFNILLLASLQRKTRQDDDQEVVEVVVKQLEEFAAKVYLVLNGSMEGFEKVVLAPEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M3BZ60</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_148687</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="OMA" id="QAMPDRW"/>
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        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
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        <location>
            <begin position="137"/>
            <end position="182"/>
        </location>
    </feature>
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        </location>
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        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <end position="146"/>
        </location>
    </feature>
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        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF13356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="326" mass="37155" checksum="326B52D92549B53F" modified="2013-05-01" version="1">MPSPALGEQQQRSLTWPPTTLRHSTVDVDAKYMPATTPTIHPIIMPSTTKRKPLRPDSFEDEIDQDPAAHFLSPVKMVYEYDDWAEESDNDNTEDVAWDAGIVDFAHFHSDRQQAQAGHTTSLPTDRWDSLLASQHSALQRAMQRNRSSRPEPTRNRIWTPPAEDVPHLTPDNSPNLRDSFDMERYCGRPAAAAAARPSIPNYLQSNFTPAEELSDDDDYDDDDDETDSDEDELPVAYLVERARERRRAARKLERPGMRFNRTMSGKVHVWKRPGYQLPDVGEDAEAERRAELAYVQLQGGGGGGRRRRRSPSRGTSQHEQRGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M3C1Z0</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">SEPMUDRAFT_115598</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016901177.1"/>
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    <dbReference type="HOGENOM" id="CLU_1462200_0_0_1"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF14321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="185" mass="20907" checksum="B8E93E33CEB13A3F" modified="2013-05-01" version="1">MDDLVRVVGVVDRLGSEVEAEVEAEVEVEQGTEAEAEGEGEGEGEGEAEGQADREAEGEAETETEAEADTDAEAEADSDSETDTEAWAEWAEWAAWDMVEHLRAVLVEQISLAETDELLESEEEEPPTFNERFLRYELSHEGQMELMETLGGPLNMRLPRRLLRTLKRAWKDWARLEEIERELLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M3C2E5</accession>
    <name>M3C2E5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FMN-dependent alpha-hydroxy acid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_148131</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762537.1">
        <property type="nucleotide sequence ID" value="XM_016904725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C2E5"/>
    <dbReference type="STRING" id="692275.M3C2E5"/>
    <dbReference type="GeneID" id="27901862"/>
    <dbReference type="eggNOG" id="KOG0538">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020639_1_0_1"/>
    <dbReference type="OMA" id="TYITWDY"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF140">
        <property type="entry name" value="FMN HYDROXY ACID DEHYDROGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0288">FMN</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004031566" evidence="6">
        <location>
            <begin position="18"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="7">
        <location>
            <begin position="43"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="124"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="309"/>
            <end position="313"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="332"/>
            <end position="333"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF14416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="390" mass="42597" checksum="8BF458C7514CD7A0" modified="2013-05-01" version="1">MRATFTSLLATAGLARAARPYLEFPDTGAAEQYGTIEAGGALPDVATVVGLPDFQYLAEQYMNLTAYTYYRNGAAGEWSYRNNLEVFERMRFRPRVMTQVDNIEDSLPTTILGYNFSSPFFISPCARAGYAGSWGELGLQAGAAAGNILYQVTDFPSIPKEELQAARAEGQITFQQLYIDPSNDTATLEQIRETERLGFHAIVLTVDSAADGNRHRAARFGVGSADSSYSSITWEKYNWMRSQTDLPIVPKGIQTVEDAIIAHENNVPAIFLSNHGGRQVDSSPSTFEVALEIHEQAPYIFQDLEVWADGGVRYGGDVVKLLALGVRAVGIGRPFMFANIYPDGAGVKRAIDIMKREVAIDAANIGIGNLKDADATWLDLKRGLSWAPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M3C318</accession>
    <name>M3C318_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Enolase C-terminal domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_148312</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762792.1">
        <property type="nucleotide sequence ID" value="XM_016904843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C318"/>
    <dbReference type="STRING" id="692275.M3C318"/>
    <dbReference type="GeneID" id="27901980"/>
    <dbReference type="eggNOG" id="ENOG502QRKX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030273_1_1_1"/>
    <dbReference type="OMA" id="WGYAELR"/>
    <dbReference type="OrthoDB" id="17395at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050032">
        <property type="term" value="F:L-rhamnonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03327">
        <property type="entry name" value="MR_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.120:FF:000005">
        <property type="entry name" value="Putative L-rhamnonate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023444">
        <property type="entry name" value="L-Rhamnon_dehydrat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046945">
        <property type="entry name" value="RHMD-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011968">
        <property type="entry name" value="PRK15440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13794">
        <property type="entry name" value="ENOLASE SUPERFAMILY, MANDELATE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13794:SF58">
        <property type="entry name" value="MITOCHONDRIAL ENOLASE SUPERFAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00179">
        <property type="entry name" value="mandelate_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00006">
        <property type="entry name" value="rhamnonate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mandelate racemase/muconate lactonizing enzyme C-terminal" evidence="5">
        <location>
            <begin position="173"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF14671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="429" mass="47289" checksum="00C2C732DC197D23" modified="2013-05-01" version="1">MANKSSVTRFPRIKEIKTFIIQGVGSGGDYHNVKGGHWLIDSKISTPMSGYEAYRTSRTSWGINVLGSFCVEIEADDGTKGFATGFGGPPACWLVAEHFRRFLIGADPRDTNHLFEQMYRGSMFYGRKGLPVAVISVIDLALWDLVGKIRNEPVYKLIGGATRERLNFYCTGPEPASARDAGFTGAKVALPYSPGEGPEGMRKNIEYLRKKRAEVGPEFPLRVDCYMSLNVPYTIELVEKCKDLDIDWWEECLSPDDFDGHALIKAAHRTVKFTTGEHEYSRYGFRKLIEGRNIDILQPDVMWVGGLTELLKVSAMAAAYDIPVIPHASGPYSYHFVVSQPHSPFQEYLANSPDGKSVLPVFGNLFTNEPIPTNGFLDVSVLDLPGFGLELNPAAPLIDAAGILNPSPSRSLPAPEQEHPDRTINGSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M3C4M8</accession>
    <name>M3C4M8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_154123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763377.1">
        <property type="nucleotide sequence ID" value="XM_016907547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C4M8"/>
    <dbReference type="GeneID" id="27904684"/>
    <dbReference type="HOGENOM" id="CLU_937406_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF15256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="297" mass="32619" checksum="CCE4D5DDA960AF68" modified="2013-05-01" version="1">MCCVASYVEAYSCISLAVHLHVKGLLGLGLGLATTDETDQARPGDEREAEEQTKKKRTRHAARSSQRDNNNEVLGTVHPARAAAVHLAPRSEVAPRRACSIDHVPRLVPLDTRHPSEHTCACAVPLPHYLYLTTLVAALKQVWFAMGWAGAVLLGQVANDCLIAIAVEMRDTNALRADGPDNWSILCYGREGGYDYEGTRSVVQNGRFTFRRDDTRAVAMFGCLQVDRHYLSCPLIRYLFTCFEPILRCGGGRAAGMESDWQRMAGQHVNIVVGTLPSTSYEEVVCGDETDAQTNTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M3C5C5</accession>
    <name>M3C5C5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PK beta-barrel-protein domain-containing protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_131141</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763577.1">
        <property type="nucleotide sequence ID" value="XM_016902399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C5C5"/>
    <dbReference type="STRING" id="692275.M3C5C5"/>
    <dbReference type="GeneID" id="27899536"/>
    <dbReference type="eggNOG" id="ENOG502SEJJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003827_17_2_1"/>
    <dbReference type="OMA" id="WSVLNVQ"/>
    <dbReference type="OrthoDB" id="5390at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06185">
        <property type="entry name" value="PDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.20">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052353">
        <property type="entry name" value="Benzoxazolinone_Detox_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30212">
        <property type="entry name" value="PROTEIN YIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30212:SF2">
        <property type="entry name" value="PROTEIN YIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="4">
        <location>
            <begin position="48"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="5">
        <location>
            <begin position="234"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="3">
        <location>
            <begin position="491"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF15456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="579" mass="64708" checksum="AF0651844A459D6E" modified="2013-05-01" version="1">MAPSRVNIAREHILNLQPAPIPEPGIVLQIRTGKKQALGPHESAIAKHPIEGLIFASETGLTGDEHVYRFHGGTERALHQYNANHYADWRAEDPPQPELFDIGGFGENLTTTNMNEENVCVGDLYQLGEHVLLQVSEPRNPCYKLNVRFAWDRALKRIQRTGRVGWNYRVLRTGYIQTGDSISLVERPHPLWSVMNVQRVIQAPSVPLRLLEECSELEVLTDKFRGLAARRLEAASKRYTVVDITRITPRVKQFTFTLREPLRLSNPAFSPFAFAHIRFGPDFGFARAYSIVSGDLRTFQLGVALDEHSRGGSEYLHHQLQMGDEIEMVSGANPRAVADEEMCNEKQCVSHRLVIVGGIGITAFLPAITQWQQEGLSFEIHYAVRSDEDAAFTTTSTTRSSTTGSTSTATLPPEATHIYSKAHNQRMDLTALIPPPLTRTKIYCSGPTRLLQQCQQLTTELHYPTHMTHFENFQQSSSSSSPNSSNRGAPFTVQIHEPETGRKEILHVPAEKSLLQILREAGFENVMSSCETGACGACRVTLCKGEVEFRSTVLMEGERKRALQSCVDRGVGRIEIEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M3C6U7</accession>
    <name>M3C6U7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_147678</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HEATR5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764072.1">
        <property type="nucleotide sequence ID" value="XM_016904454.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.M3C6U7"/>
    <dbReference type="GeneID" id="27901591"/>
    <dbReference type="eggNOG" id="KOG1822">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000503_0_0_1"/>
    <dbReference type="OMA" id="NQCENAD"/>
    <dbReference type="OrthoDB" id="192608at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040108">
        <property type="entry name" value="Laa1/Sip1/HEATR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046837">
        <property type="entry name" value="Laa1/Sip1/HEATR5-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057981">
        <property type="entry name" value="TPR_LAA1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663:SF0">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663">
        <property type="entry name" value="HYPOTHETICAL HEAT DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20210">
        <property type="entry name" value="Laa1_Sip1_HTR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25808">
        <property type="entry name" value="TPR_LAA1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LAA1-like C-terminal TPR repeats" evidence="3">
        <location>
            <begin position="1274"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1416"/>
            <end position="1446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF15951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1446" mass="156652" checksum="3B40DEEC4249D18C" modified="2013-05-01" version="1">MIGGLMSLGPNFVKIHLSQLMLLWRNALPRPMLKENMTQRNMLEVSYLAHVRECALGAIKSFLTYNQRLLTSDVSRRLAGMLENTVTFLQNLPAKKTSDEPANRLKAGLQLQDYEVMVRRRVFECFSQLLCLSPAGSIESTAHSSILPLAVASFSDLEYDAPTSLSAAIASATAAFESIWELGDNYGFGVNGRARGLDLLNPISGKLERHWTSRSDVESEIDQTLLSPIGRAAENDPTCCYLPTTNLEEDLSGPPATESVDSAIAAFALCLPLQSPRVQESTLEQMASSMGANLQKDPVRKVAITANVALALSTALRVATGDIGSAKGNLQSANTEKSLQSLLHVCVKDPDESIRSTAATALGRLCSSSGTAFTGVEVTQLTETIVNNREPHVRAGCASALAHIHSQIGGMAAGLHMKNIVGILMSLAADTHPLVHFWALDSLSQIAESAGLNFSGYVTSTIGMLCQLYVSDGHTEESASQASSNMAMGLPVTATIARGVDAVINVLGPDLQDMAKARDMILTLVRLFSHESDVSILLESLRCWEHLSLYAPGHLQFEEYVRRLQDDADSMSPEISSVALHGLFTLMRRDAPEIIRTARPGLEERLWEHLNLDPGQRSIQDIFLNWLQQTGTSDPGDWIERCNTVLTKTVVKSEQQPRTAGPVSTAGPELQDEEVAGFAVTAGAQKEDDTQAPSSAQELMRWQVRLFAMECLRNLIAMIRKEAAISDDSPGEAALQNKVADVIRIAFSASTAGVTALRVVGMQIIDQVLKMFGRTPDPDFAEAMLLEQYQAQISSALTPAFAADSSPELAAAAVDVCATFIATGIVRDAERMGRILKTLVSALESFSRDSETAAIGDLRGLTSNAQVMVRMAVFSAWAELQMASGEQEYLVDIVKPHIAQLVPLWISSLREYSRLRFEPDISATTATPATSGDLDMVYAALNRETLLGFYQASWLSLVDAIASLIDEDSQFVFDALDNKDTDTAKIESGAANSIAQKNAGINYREEPVAFFFVLYGLAFESLAVRSGTDDVLVRQKNLDILAALKKILRPSVSGMAVFQEVVFAETMDLLDRMVLTESLAMQEIIIEIARNLCLVHPSSRKGQQGANHSEDLSEDIEQLFELTRIIILVIAGLVPGLTDTPVASHLETSEEAINLIRAALQALVDVSEVFISIIKTDLHASILHIFVTILGTASCQATVVPQALPIFRRFVASLAEDKQPETKQQIHSALKRMLAILRNAQTRESEASLPCEKNTLLAITILLSTAQQFFGPEDPLVIRFINELRECLAAPTTTKVSAGCYRTLISQSVAPRLTFSHLVSFLIDAPDLEGIDETKLVVSPILTSTVSRLAPEQKPAAVVLLVHTLLVYAGNAGPSAHHSIASSLLQLAATEPATFRNLIGAMSGPKKVLMEQILKSQAGNRRGGRQEGSGGEDREPTIALKMNFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M3CE63</accession>
    <name>M3CE63_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial</fullName>
            <ecNumber evidence="10">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Succinyl-CoA synthetase beta chain</fullName>
            <shortName evidence="10">SCS-beta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SEPMUDRAFT_88810</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>succinate + ATP + CoA = succinyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for GTP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 12">Belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="10"/>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759457.1">
        <property type="nucleotide sequence ID" value="XM_016910485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CE63"/>
    <dbReference type="STRING" id="692275.M3CE63"/>
    <dbReference type="GeneID" id="27907622"/>
    <dbReference type="eggNOG" id="KOG2799">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037430_0_2_1"/>
    <dbReference type="OMA" id="ITACDEV"/>
    <dbReference type="OrthoDB" id="1552at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042709">
        <property type="term" value="C:succinate-CoA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006104">
        <property type="term" value="P:succinyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000002">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000001">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000004">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00558">
        <property type="entry name" value="Succ_CoA_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
        <property type="entry name" value="Succ_CoA_ligase-like_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001913">
        <property type="entry name" value="PRK00696.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01016">
        <property type="entry name" value="sucCoAbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815:SF1">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP-FORMING] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="SUCCINYL-COA SYNTHETASE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001554">
        <property type="entry name" value="SucCS_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2 10" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="ATP-grasp" evidence="13">
        <location>
            <begin position="34"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="78"/>
            <end position="80"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="353"/>
            <end position="355"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00063570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMF11336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="436" mass="47206" checksum="5DE69D70CE867344" modified="2013-05-01" version="1">MFKVARSSRHLASAFQSPLRQQVRNLSIHEYRSAQLLDSYGIGVPKGSVAHNAKEAEEVAKTIGGDDMVIKAQVLAGGRGKGHFTNGFKGGVRIVYSPREASILADQMIGQKLITKQTGEKGRICNSVYIVERKFARREFYLAILMDRATQGPVIVASSQGGMDIETVAKESPDAIITTPIDIHKGVTDEIARGIATKLGFSEQCIEDAKDTIQKLYKVFQEKDATQIEINPLSETSDHKVLCMDAKLNFDDNAEFRQKEVFSWRDPSQEDADEVKAGESGLNFIKLDGDIGCLVNGAGLAMATMDIIKLNGGAPANFLDVGGGATPEAIRQAFDLITSDPKVTAIFVNIFGGIVRCDAIAKGLIGVVESMNLRTPVIARLQGTNHEAAAKLINESGLKIFSIDDLQTAAEKSVQFSKVVKMTRDIDVGVEFTLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M3CFE7</accession>
    <name>M3CFE7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Saccharopine dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_117127</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760669.1">
        <property type="nucleotide sequence ID" value="XM_016901309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CFE7"/>
    <dbReference type="GeneID" id="27898446"/>
    <dbReference type="eggNOG" id="KOG2733">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046808_0_0_1"/>
    <dbReference type="OMA" id="TDCLAAH"/>
    <dbReference type="OrthoDB" id="10268090at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43781">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43781:SF1">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Saccharopine dehydrogenase NADP binding" evidence="2">
        <location>
            <begin position="14"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="239"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF12548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="339" mass="35981" checksum="A8668464E7BD633F" modified="2013-05-01" version="1">MSTVLIYGATGYSARLILEHTDFASLPGPVILAGRDETKLQVLAKKWGLSYQAFTLDSASTIETQLQNVHTLLNCAGPFAQTAEPLMRAAVRTKTNYLDISAELESYLLAEELDQQAKASGVVLLPGCGVCMTVMVGLTAHVLKRVNTPSTVSTAIFMPGSITPGTARSAGGDQTLRRLTRSNGDLVSGDSGSAKSFDFRFDSGPVHTIMFGMPDVIALWHTFKVPNITSYIYMEASSASSSGASGGDANDAADGPSREEREVKRMRASVEVIAADGAVARSVLETVNGYTMTARAATEAVRKIMNAAAVKNSGGFHTSATLFGEDYIQTFDDLSITDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M3CFJ8</accession>
    <name>M3CFJ8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">asparagine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Asparaginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SEPMUDRAFT_125747</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Asn) + L-asparagine + ATP = L-asparaginyl-tRNA(Asn) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9659"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="3"/>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760719.1">
        <property type="nucleotide sequence ID" value="XM_016902007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CFJ8"/>
    <dbReference type="STRING" id="692275.M3CFJ8"/>
    <dbReference type="GeneID" id="27899144"/>
    <dbReference type="eggNOG" id="KOG0555">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004553_2_10_1"/>
    <dbReference type="OMA" id="DCCLYPR"/>
    <dbReference type="OrthoDB" id="1931232at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04323">
        <property type="entry name" value="AsnRS_cyto_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000040">
        <property type="entry name" value="Asparagine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1910.20">
        <property type="entry name" value="asparaginyl-tRNA synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048952">
        <property type="entry name" value="AsnRS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF16">
        <property type="entry name" value="ASPARAGINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20917">
        <property type="entry name" value="AsnRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="275"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="73"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMF12598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="576" mass="65660" checksum="E221043ECF72E77E" modified="2013-05-01" version="1">MADTTKKTIYIDEVAGQDVAESAGTEAEPYKSLQFAYVLHTDSVEYLVKKAEKDEEPLYKPAAKAALKKAVNYADAQKKKAAKEQELAIREKKLEEERQKVLEDSKKVVLAEDKNLPKATKIHLGETRPEVVKLGSGERSKEVDYSDPNRGTRVRVMGRVHRMRDQKSVLFITLRDGHGYLQCVLTGDLVKTYDALTLTRESSVEITGEMWEVPPGAHAPDNRELHADYWRVIGKAPGGEEAITNLVQAKGDAQTLLDRRHLVLRGEQASAVMFVRDAVEHAFNVKYHELGYVKVSPPALVQTQVEGGSTLFSLDYYQEKAYLTQSSQLYLETAIPFAGNVYCIEKSFRAEKSLTRRHLSEYTHVEAELDFITFDDLLEHLEDMICGVIDIVLDNPRYAKMIKELNPDFTKPERPFMRMKYSDAVEWLIKHEIPNEEGEPHKFGDDIAEAAERRMTDIINKPIFLTHFPVEIKAFYMQKDPADKRVTESVDCLMPGVGEIVGGSMRMDDYDELMAAYQREGISPDAYYWYTDQRRYGTSPHGGYGLGLERFLAWLCKQHTVRDTCLYPRYMGRCKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M3CFW2</accession>
    <name>M3CFW2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_108175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760819.1">
        <property type="nucleotide sequence ID" value="XM_016900723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CFW2"/>
    <dbReference type="STRING" id="692275.M3CFW2"/>
    <dbReference type="GeneID" id="27897860"/>
    <dbReference type="HOGENOM" id="CLU_1332674_0_0_1"/>
    <dbReference type="OrthoDB" id="3650590at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004031834" evidence="2">
        <location>
            <begin position="18"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF12698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="206" mass="21498" checksum="3572F18A14879256" modified="2013-05-01" version="1">MQFITFATALFASAALATPVDPPGGPNYNANSNVVPPPGGPKYNPNSNVVPPPGGPSYKPKTDLVPPPGPPKYKPASDLVPPPGGPVIPDNTHFYPPPDFVPYPYPGVTPGHGGDANGPYFGSCSCAVFGQQSDLVGEGACKTLAQDWPNLWWNGQGCVDSLQAGIEKNGFGEACKAFAKPLLDWPFSLLGFPDLDSCVQAVCTPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M3CGP7</accession>
    <name>M3CGP7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_86478</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat UTP18 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761094.1">
        <property type="nucleotide sequence ID" value="XM_016910415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CGP7"/>
    <dbReference type="STRING" id="692275.M3CGP7"/>
    <dbReference type="GeneID" id="27907552"/>
    <dbReference type="eggNOG" id="KOG2055">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011055_1_0_1"/>
    <dbReference type="OMA" id="DLNRATY"/>
    <dbReference type="OrthoDB" id="1935146at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000292">
        <property type="term" value="P:RNA fragment catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000549">
        <property type="entry name" value="Small nucleolar ribonucleoprotein complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045161">
        <property type="entry name" value="Utp18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18359:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 18 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18359">
        <property type="entry name" value="WD-REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="88"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF12973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="586" mass="64824" checksum="E3A06D2D29919070" modified="2013-05-01" version="1">MEEMEIEYADSGSEADIVVDGEMEKDATEEELERLVFGDRMGFREGLRHFDVDEADSADHDDDGDDATTGLEGLDDAQLFFTDTGDDSLHAPALTHGDHSDDETLRSKQPPAWEDSDDERMLVSLASVPRLRKLRKTDAEDVVSGREYTRRLRKQFELLHPAPQWAKMALQKPAKKKRRTMEYIGSDEEISENDMELDEDLPSSAPLDQLLQDAESLVRQAGPGAGKKRKIRPEVIDIQRQKDIAGVQPSAITSLSFHPTLPLLLSSGPSSTLYLHHLCSAPPAPTPNPLLTSLHIRGSALTTTAFHPADSRIFLSARRKYFHVWNLTTGQVEKVTRIYGQQHEQKSMEHFKLSPNGKYMALQGSTKKGGGIINVLDATTLQWVTQVRIESRGGIADFAWWRDSRGLCIAGKNGEVSEWSIAEQRIVARWQDEGAVGTTTLALGGQHEVRSGLVGTDRWIAVGSSSGIVNVYDRRAWLGDHPKNAQIPQTPKPTKALDHLTTPTSHLAFSPDGQILAMASKWKRDSMRLVHLPSCTVFRNWPTSSTPLGRITGVAFADGGVVQGSDAHSVLAVANEQGKIRVWEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M3CJG9</accession>
    <name>M3CJG9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Monopolin complex subunit Csm1/Pcs1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_149055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762054.1">
        <property type="nucleotide sequence ID" value="XM_016905311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CJG9"/>
    <dbReference type="STRING" id="692275.M3CJG9"/>
    <dbReference type="GeneID" id="27902448"/>
    <dbReference type="eggNOG" id="ENOG502R6WM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029214_2_0_1"/>
    <dbReference type="OMA" id="SDNLYDC"/>
    <dbReference type="OrthoDB" id="2431049at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034506">
        <property type="term" value="C:chromosome, centromeric core domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033551">
        <property type="term" value="C:monopolin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990644">
        <property type="term" value="F:microtubule site clamp"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045144">
        <property type="term" value="P:meiotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23787">
        <property type="entry name" value="RWD_CSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.80:FF:000001">
        <property type="entry name" value="Chromosome segregation protein (Pcs1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040349">
        <property type="entry name" value="Csm1/Pcs1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020981">
        <property type="entry name" value="Csm1/Pcs1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038608">
        <property type="entry name" value="Csm1/Pcs1_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28006">
        <property type="entry name" value="MONOPOLIN COMPLEX SUBUNIT CSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28006:SF1">
        <property type="entry name" value="MONOPOLIN COMPLEX SUBUNIT CSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12539">
        <property type="entry name" value="Csm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Monopolin complex subunit Csm1/Pcs1 C-terminal" evidence="2">
        <location>
            <begin position="398"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF13933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="516" mass="56750" checksum="2F71348CAA8018E6" modified="2013-05-01" version="1">MPPRTKVHAAAGAADSEDELDVLSTNAPKRATTSTAKMSKAKTAVRRVSASKAVATKRKAATRQPRTALKDKTNLQDGNETEEVDDFDADDAAVKPKAKRAKTAATRNNAKGPPDEVAAREPVKKATGAKRGRPAKRVPSPEPMVTIPETQPDPQYMEDVEQSIELDPENMDIEREPTPPPARKFAQRAPSVPVQPLLPRPSARTDPLQPRPSGRAASAQPSYPTARSREGSANAPERRGGDPELRRLLHDMTKKYENLHLKYESLEDIGKRSAESNFEKLKRASDQKAKDAQELIAALRKELAEAKQSSSSASSETTGMQKQITNLEATNEKTSAECNALKEKLKVSENEVKSLEAKLNAARQQISNTAQETKMLEAAAKKNSSISVNQSESQKEAKMKENLYADLTGLIISGVRRHEGEDVYNCIQTGRNGTLQFHLSVGNDATTPNPKTPSGLSHEEAEFAYEPVLDESRDRELLELLPDYLSEEICFPRNHAQRFYGKVVESMTKKIVVEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M3CNS4</accession>
    <name>M3CNS4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peroxin 11C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_147301</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763524.1">
        <property type="nucleotide sequence ID" value="XM_016904211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CNS4"/>
    <dbReference type="STRING" id="692275.M3CNS4"/>
    <dbReference type="GeneID" id="27901348"/>
    <dbReference type="eggNOG" id="ENOG502S1P2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052213_1_0_1"/>
    <dbReference type="OMA" id="DWIRPLA"/>
    <dbReference type="OrthoDB" id="10005898at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008733">
        <property type="entry name" value="PEX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652:SF25">
        <property type="entry name" value="MICROBODY (PEROXISOME) PROLIFERATION PROTEIN PEROXIN 11C (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05648">
        <property type="entry name" value="PEX11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="1" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF15403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="34128" checksum="3EAB08059802C928" modified="2013-05-01" version="1">MSEPASQPGAPADGAQKQDFPANEKSVAKEIEKKMPVQVKSSLAGPDRVILRLNKLLASPGGLSSFLSTFNYTLYLLAHLDAKAAPLKAKLYLFLNRHASTASKLTPPVSTDPSPIAALGSLLSATRTTLRLFGLLPMYAWARQLAQGPKPGQDSVLYATAVTQCVLYIAFQLFENVALLTDSKILPGSLTARWTEKHGGKAAAIYLASYRAWFLGFCCDFIRLFREAQLERNKRDARSSVEKSYGSVAKEDAKKDAQWWSEFIVPLAWFPVGWHFAAWNETGFPGFNLGLMGAAGAIAGLGKTKALWDATADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M3CVF4</accession>
    <name>M3CVF4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_136932</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF08132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756253.1">
        <property type="nucleotide sequence ID" value="XM_016902814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CVF4"/>
    <dbReference type="GeneID" id="27899951"/>
    <dbReference type="HOGENOM" id="CLU_717992_0_0_1"/>
    <dbReference type="OrthoDB" id="3644957at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="167"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="228"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="197"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="230"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF08132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="385" mass="42354" checksum="AA1A9D34C297C8FA" modified="2013-05-01" version="1">MDPQIAFSDLFQPIGDALAGLFKDVNTRIEAVQQQNTALQEQYEALRKKHDADINKLQDIIGTILHEHNELEAQLLPVLPVINGMAAGIKSSTENLTPSDLTTSKKLPALRPLSQRSSDGFDRSHLPWLAAFRAQSSVTFRAVSQELEDSVGEFDEAPLQAKASAIKRTMSQRHSENGSFEDVPHKRSGSLQRKRGRSDLNKASRESVEKSSMEYLDIEDSDVEDFNATLEGTPQPTSQVQKSVAYAQTGPNQQEPGDYNDLSSEIVVARPKTRDAASRSYLQLPGDPNHSELSPASQSHLRKLSAGQTSAGEMLESIAKAAPPPNSSQRSHFFDTDLKGSPAGRRHSTRDTKKKPPPDGFIDVRTLRNDKKVGLVLKKAEEIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M3CVP8</accession>
    <name>M3CVP8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anaphase-promoting complex subunit 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cyclosome subunit 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_152466</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF08217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756338.1">
        <property type="nucleotide sequence ID" value="XM_016907462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CVP8"/>
    <dbReference type="STRING" id="692275.M3CVP8"/>
    <dbReference type="GeneID" id="27904599"/>
    <dbReference type="eggNOG" id="KOG4322">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010478_0_0_1"/>
    <dbReference type="OMA" id="DANMGMA"/>
    <dbReference type="OrthoDB" id="2504561at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037679">
        <property type="entry name" value="Apc5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026000">
        <property type="entry name" value="Apc5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12830">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12830:SF9">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12862">
        <property type="entry name" value="ANAPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 5" evidence="9">
        <location>
            <begin position="278"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF08217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="803" mass="90229" checksum="7FBD6A8AD41CC7F6" modified="2013-05-01" version="1">MPRYLTPARVGLLFLIELYFESDRQDGLDHHAAAGILEFIAKHTILTVDNDAQLIDEKNAICTLDISSFRPHLQPFDATYVSHHWNLTRRGTAWDAFLATCFEHGSKGQQDLHDLITRLRTTRVRTPGSKIRLSKPVTFARPVTPGSPLGQFIRRCYIEFTRLQFGDLQALWKSFEVWRASGWEQLVKFCPVLTQEILHHQQERNSNEETHASFCQRTDFATDAHNSAAAVDTDMLLTHAIRQLQQLGTRVPENVKTKLASWVDELSASSAGTQSMHFFMAFFEHSKAGQYTMALESLHRYFDYSLAARNSGGAGDNVNLRIYYQYALLHLSVLHADFECWEESVDAMNECIATARENQDTACLNFALSWLLYLRHAHPGKGTAAYASISGVVGGGEQDEIAFLKTKARESKNWLLMSSTLLEEGRQELFCGGNANRAQEHVLQARYLSMQHDLRTMAPATQLFYGSCMERLGQAHLANRQYEIANTVHAAHCPVNDRVRATCRSALALAYQGSYTKALSLLDELTPTVRSILKSYTRVQVFSALIHLRRSIHRGTHEASSYYINQVLPLLSAADPELSHEFYALQVEHCIAQNDYPTAMEKVNIHLNTTGSLGTTADLAQRLYWLIQKARIFAEAGRAAKGFSLCLRATFTAERHLLVPIMLEGLAVLGRVLIEVGEFEAAQEMYQSALPVALGGGNARLVARMWVGMGESCVGLAGKMQQREDDGDASSMAGEQTRLMRRAEDSIERGRVVFEKLEDVEGQMVCLTMKSRILQWSGDEGAMRQAEEMFADLVMMKRQQIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M3CVY7</accession>
    <name>M3CVY7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Pantothenate transporter liz1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_54444</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756423.1">
        <property type="nucleotide sequence ID" value="XM_016909297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CVY7"/>
    <dbReference type="GeneID" id="27906434"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="OMA" id="GFTTMMQ"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF46">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="455"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="72"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF08302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="516" mass="57981" checksum="81F87403E4A24724" modified="2013-05-01" version="1">MKFPFYSSKESKPDYPPTSPPEKLFPQPTTTTNDHQHHQGQEELSSTSEETIPSCPPNTTPQKLLLRIDLHVIPFLCILYLLAFLDRVNISNANVLGLSEELGLERIEYNSALVIFFVPYILLEIPSNILLKKFKPHIWLSLNMFLFGFVTIMQGLVQNYSGLLTTRFFLGVFESGMFPGCFYLIGMWYRRHEAQKRYTFFFSSTTLAGAFGGLLAAAIGKMSGLRGYAGWRWIFILEGALTVAVSFIFFFCIPSFPEEAAWLSPDEKAYVAARLRMDQGRSAAERKITLRDVQRVFKDYKVIVAGFMYFGLIVPAYSYAYFAPGIIQSYGYDPIQTQLHSVPPWAAAFAWAMLLATISDATKHRFGFAVLSICVGITGFGILITVHDNQPLQYAALFLVTMGTYGAMPIIVCWFNMNLGGHHRRSVGSAWQVSFGNIGGIIAVFAFLPEDAPKYVTGYSICIAFTILSILSCIVYGWACWSQNRQRERIGMGDEGLTEGEKTELGDMSPTYRYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M3CWA8</accession>
    <name>M3CWA8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_152281</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF07946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756067.1">
        <property type="nucleotide sequence ID" value="XM_016907348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CWA8"/>
    <dbReference type="GeneID" id="27904485"/>
    <dbReference type="eggNOG" id="KOG0253">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_52_1_1"/>
    <dbReference type="OMA" id="WTMVVSS"/>
    <dbReference type="OrthoDB" id="4139357at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="559"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="98"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF07946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="584" mass="64585" checksum="D902716B8BDB7DBE" modified="2013-05-01" version="1">MAATAHRQDSSVPLLAKERSLEQSRRESREGESSSSSSSSSGLTRERTSSSQDIQNRPVAELPGYDSDGIPLSPMEMKYRMVDAEIDSHGMGTYQWFVWWLCGLGYLLDLLWAQAFGLVLGPLQQELGFSEGESGNISIAFSVGLTAGALVWGILGDIIGRRWVFNLTCFISGAFGIALGTVHTYGQFLAIVVFMGFGIGGNIPVDTTICLEFLPSNRRFLLSLLSIFQPIGVVGTCAIAYAFVPSYSCRPNFSEENALPSCNRVPAGTEECCSSAQNMGWRYVIYTLSAINVVVFLLRFVVFTIHESPKFLLSHGRDEEAISVLEAIAKSNRTDCKLRLRDLERADMDSDGASGLTGRVEFTDKRYWKSKMRTKISKYKQLFHGPQMTRITILVWLTYIFDFFGFTLAGYYLPKIIAIKNAQIALSLRQTYRNYIAIYSPGILGVTIGAILVRVPKFGRKWTMTLSSGFMGCSILAFSSVNSQASNIGLNALEHFFQSMFNAVLYGWTPEVFPAEIRGTAVGLATTWGRLFSILAPLIAEKMQDGEEGLKNPDTIRRFLYLAGGITLGCVVTTAALPNRIRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M3CWG5</accession>
    <name>M3CWG5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">thioredoxin-dependent peroxiredoxin</fullName>
            <ecNumber evidence="3">1.11.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Nuclear thiol peroxidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Thioredoxin peroxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SEPMUDRAFT_152119</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the peroxiredoxin family. BCP/PrxQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="3"/>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756588.1">
        <property type="nucleotide sequence ID" value="XM_016907255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CWG5"/>
    <dbReference type="STRING" id="692275.M3CWG5"/>
    <dbReference type="GeneID" id="27904392"/>
    <dbReference type="eggNOG" id="KOG0855">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_2_0_1"/>
    <dbReference type="OMA" id="CTNQVCL"/>
    <dbReference type="OrthoDB" id="338622at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03017">
        <property type="entry name" value="PRX_BCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000157">
        <property type="entry name" value="DOT5p Nuclear thiol peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050924">
        <property type="entry name" value="Peroxiredoxin_BCP/PrxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801:SF23">
        <property type="entry name" value="PEROXIREDOXIN DOT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801">
        <property type="entry name" value="THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="15">
        <location>
            <begin position="51"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00077538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMF08467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="256" mass="26470" checksum="E5BCB905FB779D8F" modified="2013-05-01" version="1">MVELRKRKEAPPPPPPAKKRAPSKAKKDAPKVEKEAEAAKAPEVAVEDAPPAAVEEAPAATKATGPPKVGESIELNGFGGEVQTHSEEATTLAKLLEASKSGVVLFTYPKASTPGCTTQVCLFRDAYDDLTKAGLSVYGLSNDSPKANKNFVEKQKLQYPLLCDPKQTLISAIGLKKAPKGTTRGVFVVDKTGKVLASEPGGPAATLEVVKKIVAGLGGDADSDGIKQGEDVVAAETAADVADTAEKLDGDGASKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M3D1G6</accession>
    <name>M3D1G6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">acetyl-CoA C-acyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_150297</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21564"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.3.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.16" evidence="7"/>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759459.1">
        <property type="nucleotide sequence ID" value="XM_016906072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D1G6"/>
    <dbReference type="STRING" id="692275.M3D1G6"/>
    <dbReference type="GeneID" id="27903209"/>
    <dbReference type="eggNOG" id="KOG1389">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031026_1_1_1"/>
    <dbReference type="OMA" id="QMGMDHL"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000010">
        <property type="entry name" value="Acetyl-CoA acetyltransferase (Thiolase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050215">
        <property type="entry name" value="Thiolase-like_sf_Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853:SF5">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="11">
        <location>
            <begin position="18"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="12">
        <location>
            <begin position="291"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="9">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="367"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF11338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="411" mass="43270" checksum="740107CBB4D4E391" modified="2013-05-01" version="1">MAMQRGLKNILAMNADDIVILSALRTPVTRAKKGGFKDAHDHELLSHVLRATLAAHPNLDPSKINDVQIGTVLSELGGSKAGRMAALHAGLPETATFQTVNRACSSGLAAITGVANAIRVGEIDVGIGGGMESMTRNYGSRAIPTALWGELKESQNKDARDCIMSMGITAENVAERYKVSRKEQDEFAVASHLKAAKAQKEGLFDQEIVPVKTRTIPDPEHPETTEEVTVSKDDGIRAKSTVEKLGTMKAAFKPDGATTAGNSSQVSDGAAAVLMMRRSTAAELGLSTSIIGKWAGTQVVGCRPDEMGIGPALAIPKLLSHTGISKEDVGIWEINEAFASQAVYCVRELGIDQAKVNPKGGAIALGHPLGATGGRQLATLLPELERQGQQVGVVSMCIGTGMGMASLFIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M3D1X3</accession>
    <name>M3D1X3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GRIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_69186</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759619.1">
        <property type="nucleotide sequence ID" value="XM_016909854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D1X3"/>
    <dbReference type="STRING" id="692275.M3D1X3"/>
    <dbReference type="GeneID" id="27906991"/>
    <dbReference type="eggNOG" id="ENOG502S0A5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_349037_0_0_1"/>
    <dbReference type="OMA" id="VEHERHH"/>
    <dbReference type="OrthoDB" id="1926336at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="21"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="264"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="436"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="609"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="160"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="536"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="610"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="663"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF11498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="808" mass="89520" checksum="2AFDAF1356E0290F" modified="2013-05-01" version="1" fragment="single">MSKYFKSLQTNFSLDFLDNKIAEEQEKQKQQQGQGQKAGAPGLKRSLSSARRGSSRIEPPGNRSGSRLRAPDASDGAPAIKGPDPDDFVIGDDESSASISRTATPQPAINEGKDAGSSAATAPAPASTESERSRDKDGGSQEGDKGKGKMAPEEELPELVQKKLAHLEKLTARYQDLLRNYRTAHARVSMIDPFEAALREHTPLTSIGDPGTLVEWLNQRSMQSDMVLQELKKIAGEKNEAEKERDELKTKLEDAEKKVKDAFDEAAGLRKERDEAKAESAKHGDSSAHSLGVSKAERKSTEDDAFFSYEDEVSRDGELSKQLAEKDVTLKQKTEELQAYEVREKEHTAYINELSVENASLRKDSETFRNELDVKKVDLDAANKQLEQKDAEIASIKQELAEVIAARDASKEHQDEATLSLVQTEAQLVNIQKEMKDSQEALKKKAAEAEARKSEAEDKLQKYQREHAKNLKEGKYSPDAQKGVENVRNLVKTLQANLEAKTNEVLIARAQASDMHSAMKIMEAESAQTESTMKYLRDIETTAKSDKQRLHEAEQQRDALQKVVDSKRGHEQKIVTLQMQLKQAMEDRDRAYQNIINCGKCVIPVKQDEVTTPSEVASSSKSRLGSETTNVSTQPTELGSEASTPGTPPALEDEDLQTPTGAAKKKSKKKSKKGKKKPESATGPEGADKTEHASADVTVDDLIRDQTGTAAKLRHQFEGNPLIPLLENMHDYVKKRTEADSDNHDNLIMHLEERIEVAVQNLKNKDVVLRAKDDEILELRQNMLNTISSDAKTILQGQIDDLTKEIAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M3D1Y1</accession>
    <name>M3D1Y1_SPHMS</name>
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        <submittedName>
            <fullName evidence="4">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_150142</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759248.1">
        <property type="nucleotide sequence ID" value="XM_016905982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D1Y1"/>
    <dbReference type="STRING" id="692275.M3D1Y1"/>
    <dbReference type="GeneID" id="27903119"/>
    <dbReference type="eggNOG" id="ENOG502SND1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050238_1_0_1"/>
    <dbReference type="OMA" id="HISKPSH"/>
    <dbReference type="OrthoDB" id="5337378at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="130"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF11127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="432" mass="49752" checksum="7F1D3679CF6330BD" modified="2013-05-01" version="1">MQEHRSAGNTDFWRDVEKAHLSHHHQRRWLWQRQAHNLPRSARYLVCGLVALCAVFGFMRGYSDFRDQALKQYPTDYHKLHIGRPHISKPSHPVRFSEHTSPSAAWTAPTTATADSGAKESLGGKIDERYLYVKGLGSGQEGKADLYIDQQDGSTVVVKTFSSIARNWLPTSISRGYANYTTTWPAEIEASLLLGSHDGSSGYVSVMDYFILQTPSGWSWALVTPFMARGTLAQLAADEHDSSTRETTDELDATYRHNFEAMLSQLRTLHRAGYCHDDVKPDNIFIQDPEHWLLGDLGNVRHVEHPWHGTKSWTRQNQWPDCTSNDLRRAYKSYLWFLRAASVDKARFDRDFWQETKDWSRMYWDFMQSWMAPSSRNGVANVYRAQERPSESSVEPALLVPEAGWQRKTERELLCTSIPRRLWGWSDYFGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-09-13" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M3D2W9</accession>
    <name>M3D2W9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_149202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760691.1">
        <property type="nucleotide sequence ID" value="XM_016905408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D2W9"/>
    <dbReference type="GeneID" id="27902545"/>
    <dbReference type="HOGENOM" id="CLU_2387572_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032178" description="Secreted protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF12570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="94" mass="10314" checksum="38CD2FCE1EC384A0" modified="2013-05-01" version="1">MLTSSTFTILLALMSSVHHALACQTIAGIGVGCTGFQNEFCDEAALKCPVGQCMTKKTRKSITCQYPVLYPKCIYDVCCPSFALRYWFVSRTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M3D3K9</accession>
    <name>M3D3K9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_149148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760610.1">
        <property type="nucleotide sequence ID" value="XM_016905372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D3K9"/>
    <dbReference type="GeneID" id="27902509"/>
    <dbReference type="HOGENOM" id="CLU_771997_0_0_1"/>
    <dbReference type="OrthoDB" id="10448516at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF12489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="359" mass="40210" checksum="462AE41BA518ADD2" modified="2013-05-01" version="1">MRQGQAAPSKPRHQHTRHRQSNITPVHCPKTSCSRDSRPSDMVTEPNGSTWICRTYLHSGQAATRCEHRGTGLNQLIEVKGSDMSASLSAYCRPVISDSSMTSSDEQSPEEDTSPRQNWLIGEEGRNVRATVPQPNEMGRVRDDPAWHTRVARKDVTWQRSRPSKSKAMLEAMRVSEPEATESLPPCEWSDYPNARDPPAPSCFQHCPSYTEAPGTTRHNVAESNPPEIQQNPRPLWQYQHVFTSNRPTQSELVDYPFASTRGNFADTAHLPLVPFEDPRLSDPQPKHLATDYDVDSGSLISKVFLTALPFGSMIETANLYSDEKCDICQEYAMGERGTKCDVHGAEAGTQYKSHARLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M3D4A7</accession>
    <name>M3D4A7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Benzoate 4-monooxygenase cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_117288</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760845.1">
        <property type="nucleotide sequence ID" value="XM_016901322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D4A7"/>
    <dbReference type="STRING" id="692275.M3D4A7"/>
    <dbReference type="GeneID" id="27898459"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_2_1"/>
    <dbReference type="OMA" id="RWQRWHG"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF235">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE APDB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF12724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="479" mass="54177" checksum="5AF5C9ED61B95655" modified="2013-05-01" version="1">MVLVGICVGIQLGKMVYNAHIHPLRTIPGPWLPAATTAWIRWQRWHGRLSLQADDLLTRYGSIVRISPNMVLLNDREAVEKIFARKDLDTSPKAIRALRVGGHDWTVTYPEHSVARQRRHPVMIASTTNNLKVWHSTFSKNIGHMVNELGRSQGFRSEDIVRHLRICTLKNTQPLIGGPGVDLDGADFPDVVGEYNFLVVWRLCLPEWTFGWLKYGPFNHARFRVQSSDKLFDLGAEVQEQAQAYEKQRPGTAEKNFYSLCTDTDAKYPVQAWTKDELSAEIAGQILAATETTSSALAFIYYELAKAPHLLEQLYQELVNNPDQDDLDSLKLLDACIQEGLRFRPPVALTGSRLVPAGGLEVLGHFLPQGTVVTTQSLSMSRQQPHLFPNADIYDPTRWLDAEMRAERRRYLVPFGVGARRCPGGNMALYQMKMILNSTLLAFDIEVAPETTPAKMEPFEANGYRSRHDRCDLIFKPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M3D524</accession>
    <name>M3D524_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_148642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cyclase 1 superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761416.1">
        <property type="nucleotide sequence ID" value="XM_016905051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D524"/>
    <dbReference type="GeneID" id="27902188"/>
    <dbReference type="eggNOG" id="ENOG502SHBW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030671_1_0_1"/>
    <dbReference type="OMA" id="AMPLQCS"/>
    <dbReference type="OrthoDB" id="5396at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861:SF10">
        <property type="entry name" value="CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF13295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="351" mass="38714" checksum="3D13028A90D40291" modified="2013-05-01" version="1">MVDAVKSALGMNTIPDYDDLPPVEGMPKGCAWGVWDKFRKDGKKDIYGTLNLLTPDVVKAACSEAKEGIHVSLNWPIGAIKTPGFFRKGLVHKVMSFVDTPLTCHGYDDEIEFNTQCSSQWDSLVHFHHQASQSGYNGTKTSVEELTQAFGEEDKERKLPTLNHWHDRGGMVARGVFIDFKKYADETGRAFNPYTDDKISIEDIETIAKKQGVEFKQGDVIIIRSGFTEGLTDVSAEKQAELMGSHRVCGVTGTEEAAKWFWNKHFAAVAGDMIAFEQIPPIIDGQEGPVSQLVLHQIFLGLFGMSIGELWDLKALSETCAKLNRYSFLLTSVPLNVPGAIGSPPNALAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>M3D556</accession>
    <name>M3D556_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_126058</name>
    </gene>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
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                <person name="Hamelin R.C."/>
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        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="908" mass="98251" checksum="A1A54B3BEC7BF964" modified="2013-05-01" version="1">MLGMQNETMSSAPNNYGHRQTQSFAVKPSMSPDENGFPQQSSFHRAQPSLGGYGARHGHRNSIQPINTGRMASQSYNVPDMQTPQTGYDVNFTPLLPTNLLMGSPFQPGSPTAFQSPQFQSFQQQPSGSRHHQNQMSMSQAFQQQQQQHQHQQQQQQQQQPMLSPSAYQPLGSPNAYQNSSYFGGLQSPTTGFSSIAGMQMGGYGQAMHSLAPGIVSGTSRTVYLGNIPPDTSAEEILGHVRSGQIESVRLLPDKNCAFISFLDASSATHFHSDAILKKLSIKGQDIKIGWGKPSSVPTSVALAVQQSGASRNVYLGNLSEDMSEEELREDLGKFGPVDTVKIVREKAIGFVHFLSIGNAIKAVTQLPQEPKWQAPRRVYYGKDRCAYVSKTQQQNAAQYLGIAPGYAHVLNGADRDLITNALAQQSVAAAAVATTAGGVNNLGNRTVYLGNIHPETTIEEICNVVRGGLLHHIRYIPDKHICFVTFIDPTSAASFYALSNLQGLMIHNRRLKIGWGKHSGALPPAIALAVSGGASRNVYVGNLDETWTEDRLRQDFQEYGEIELVNTLREKSCAFVNFTNIANAIKAIEAVRGKEEYKRFKVNFGKDRCGNPPRQVINNQHLQQQQQQQQQQSSENGVSSSSPVNGLAPHSQRAQHSVSPASSGPSAYNPLQGPTASTIFNTGTNNPLTLYLQATQQSAQAVAEQQAQQAQRSLSPSDYELPTTTSYQQQQQQQPTSATATHLSNQQAFYSSPNEVAASRSAGLEPPSHSHHHSHHHSHHNLHHLGHGSHQSVNITNGMQAGMNTSSSPSYSNNNNNQSSSHHSNNASSRSAHSRAVSLPAFSLQSNSNSNNANGNSNSNNNNTNNNNNNNSSSSPQPLSGLGYSSGEGYGLGVSPGLPGWAEEEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M3D5W4</accession>
    <name>M3D5W4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DnaJ-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_148804</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761671.1">
        <property type="nucleotide sequence ID" value="XM_016905157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D5W4"/>
    <dbReference type="GeneID" id="27902294"/>
    <dbReference type="eggNOG" id="KOG0719">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055868_0_1_1"/>
    <dbReference type="OMA" id="FPTWREY"/>
    <dbReference type="OrthoDB" id="110024at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000110">
        <property type="entry name" value="DnaJ domain protein (AFU_orthologue AFUA_2G13210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056453">
        <property type="entry name" value="HTH_DNAJC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052594">
        <property type="entry name" value="J_domain-containing_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44144">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44144:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23302">
        <property type="entry name" value="HTH_DNAJC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="35"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="289"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF13550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="325" mass="37114" checksum="74ADFB085DA1B4F9" modified="2013-05-01" version="1">MPKRKQQDDDEVEEELEEELEEELEEDQEMPTSINPYHVLDIPVDASQSDIKSAYRKAALKSHPDKVPEEHKESAHKEFQQVAFAYAILSDERRRKRYDTTGSTEESLDIEDDDFNWADFFRAQFKDVVTDEKIESFANEYRGSEEEKLAVLEAYTKCKGAMRKVYEYVMLSDMSVDEERFREIIDDAIESGEVEDFPKYSGESEKARKARIAKAKREKEQEAAEAVELQEEIVKKNKKPKDSSGDMRGLGDLASLIKQRQQGRAETFFDKLEAKYTAQEKGGKKGKGKAASAVAPDEPPEEAFAAMRKRADAVGGARKKSKTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M3D6E2</accession>
    <name>M3D6E2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein uS3m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_148943</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761866.1">
        <property type="nucleotide sequence ID" value="XM_016905243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D6E2"/>
    <dbReference type="STRING" id="692275.M3D6E2"/>
    <dbReference type="GeneID" id="27902380"/>
    <dbReference type="eggNOG" id="ENOG502SRRH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_863630_0_0_1"/>
    <dbReference type="OMA" id="DATWRAP"/>
    <dbReference type="OrthoDB" id="4360278at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007980">
        <property type="entry name" value="Ribosomal_uS3m_fun"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05316">
        <property type="entry name" value="VAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF13745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="366" mass="40545" checksum="09FFBA68CE6125F5" modified="2013-05-01" version="1">MPPRSISVPTGTFASHVKHLRAQRRSASTAASNLPTAAALPEIAPVWRSRTEPLTRLGQSITGAMEWQTSTYSFNKQAVKPIPVVSANVEKLIHNYVTMKHVDNEGKDVRAIRTALALRRKSAEKVYVSKPKIKDYGDRVEVKCFLWDGGEAIREELENMKRGSSSGSGGGGYRRRTNDSDLLLDPKQQVGLRSLIAKMYGKQVDLQMIKIKRPHLDADILAAYVAQRLRDRRFTPRRVIRDATWRAPLPSAQAVANITNAKLRATPQKFSWQDFTIGNVSRASATGIVESLALSQVSSIQIEAAGRLTKRLTANRSAKKMTRRGTTNKGPAYMLRGFRKAHTQFAFAGGKRRVGQFGIKVSVGHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M3D823</accession>
    <name>M3D823_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 25">tRNA-dihydrouridine(47) synthase [NAD(P)(+)]</fullName>
            <ecNumber evidence="4 25">1.3.1.89</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="25">tRNA-dihydrouridine synthase 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">SEPMUDRAFT_81861</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28 29">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs. Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>5,6-dihydrouridine(47) in tRNA + NAD(+) = uridine(47) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53364"/>
            <dbReference type="Rhea" id="RHEA-COMP:13539"/>
            <dbReference type="Rhea" id="RHEA-COMP:13540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.89"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="20">
            <dbReference type="Rhea" id="RHEA:53366"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>5,6-dihydrouridine(47) in tRNA + NADP(+) = uridine(47) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53360"/>
            <dbReference type="Rhea" id="RHEA-COMP:13539"/>
            <dbReference type="Rhea" id="RHEA-COMP:13540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.89"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="23">
            <dbReference type="Rhea" id="RHEA:53362"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="21">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="22">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 25">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="25">Belongs to the dus family. Dus3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.89" evidence="4 25"/>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762135.1">
        <property type="nucleotide sequence ID" value="XM_016910292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D823"/>
    <dbReference type="STRING" id="692275.M3D823"/>
    <dbReference type="GeneID" id="27907429"/>
    <dbReference type="eggNOG" id="KOG2333">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013299_7_0_1"/>
    <dbReference type="OMA" id="WSYIAEC"/>
    <dbReference type="OrthoDB" id="259935at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106414">
        <property type="term" value="F:mRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102265">
        <property type="term" value="F:tRNA-dihydrouridine47 synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000145">
        <property type="entry name" value="tRNA-dihydrouridine(47) synthase [NAD(P)(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45846">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(47) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45846:SF1">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(47) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25585">
        <property type="entry name" value="zf-CCCH_DUS3L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 25" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 25" id="KW-0288">FMN</keyword>
    <keyword evidence="11 24 25" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="17 25" id="KW-0520">NAD</keyword>
    <keyword evidence="15 25" id="KW-0521">NADP</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16 25" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 25" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="14 24 25" id="KW-0862">Zinc</keyword>
    <keyword evidence="13 24 25" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="27">
        <location>
            <begin position="129"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="27">
        <location>
            <begin position="179"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="24">
        <location>
            <begin position="129"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="24">
        <location>
            <begin position="179"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="95"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="200"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="279"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="279"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00045934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="RuleBase" id="RU291113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="EMF14014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="725" mass="81176" checksum="DA71DBC6895C8D09" modified="2013-05-01" version="1">MTKAEKIERHGDLNGHANGDFQESPRKRIKREHDAATAPDSTVAGEVEEERDVKQDTRTSSNQPDRQKGVAPIKKEYLIDISTLKHASATFDDDAAEAAGKAEEQPVAGRGGKKGKQGQNKARTFGSSKDAIALCRTRHWANEFDPITCPFGEKCRMEHDIRKYVKEGKREDMQTFNGVCPNFETKGKCKEGWKCRWAGSHSEEIERDDGRKELVQKQKRDTAEQCAANDHGDDEEDQDNGVVNIVSNGDKITLRKKKWATPLSDKYLKWLNSQVGEDGNRISDHDLNHDHRAAYSDPPLRPSEKRRIYYGPETPVLAPLTTQGNLPFRRLCTELGAQVTWSEMAMGLPLLNGEKGEWALVKAHESELAPPSYFPKNPVQGYDNSKDIRFGVQIAANKPWLAMKTTEVLAALCPQIRAIDLNCGCPIDLVFRTGAGSALLDGHGKLEKILRGMNTVSGEIPITVKIRMGTKDKQPTAQKLVERLVLGGNEARDANLGPAGVAAITLHGRSRQQRYTRDADWSYIAECATLVKHLRAQHADLTDTVREPDARDTANTKEGLPYFCGNGDILCPGDYNKHIDEAKVDSIMIGRGALVKPWIFEEIEKNQDLDKSASERLAYIEKFCRNGLDYWGSDEIGVGNTRRFLLEWLSFSCRYVPIGLLEYLPPKFGDRPPAFRGRSDLETLLSSGNYKDWIKISEMFLGPAHKDFQFQPKHKSNSYEIEAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M3D8M7</accession>
    <name>M3D8M7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_41152</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762601.1">
        <property type="nucleotide sequence ID" value="XM_016908816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D8M7"/>
    <dbReference type="STRING" id="692275.M3D8M7"/>
    <dbReference type="GeneID" id="27905953"/>
    <dbReference type="eggNOG" id="ENOG502QTAT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008220_0_0_1"/>
    <dbReference type="OMA" id="GSAWIFT"/>
    <dbReference type="OrthoDB" id="38531at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057688">
        <property type="entry name" value="DUF7928"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408">
        <property type="entry name" value="CHROMOSOME 15, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408:SF1">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 2-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25550">
        <property type="entry name" value="DUF7928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="666"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="705"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="745"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="802"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="829"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7928" evidence="3">
        <location>
            <begin position="40"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="2">
        <location>
            <begin position="474"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF14480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="857" mass="96397" checksum="E2D40F1C5FB1761A" modified="2013-05-01" version="1">MVSTAAPTPGNATPASWSRPASLYPVGDFRNSQAEDINEIKCDVMVNWLYQQQMERLWTAGGVDEGVVLKKSRGQYACCPADIVEEPYGFAKAIETLNVRVAMTVNTRVIKLFLHNNDRSYVPLKNGLRLQVLPDISYLPRCQKHQFAAFIADRGLLVVWDDEPRHLLDRAHKIEKSLMEMIWDDNSSIDEKKEGSVAVNEVDGSESGADLEANGSEKPRSIVLWQAILCAATLALSILCLGLGVRQLAIQTAVDKSYIRMALIVVLPLQFWVGLFFFQSVIGNLAQLIGPISQMSANTKYYSGLKPKRLRRGENGLPHMTIQMPVYKEGLKAVIEPTIASIKNAISTYEMQGGTANIFINDDGMQLISEDDARARQDYYDEHNIGWVARPKHTPKPAEGEEVFLRRGKFKKASNMNYAMWVSNRVEDKLAVVERRQGWNQEDEANAYREALSEVVEEDQGRTWADGNIRMGDYILIIDSDTRVPSDCFLDAVSEMEASPQVAIIQYSSGVMNVTDSYFERGITFFTNLIYTAIRFAVANGDVAPFVGHNAVLRWSAVQSIGYDCYFGDDREKFWSEDTVSEDFDMALRLQTAGYLVRLGAYQGDGFKEGVSLTVYDELARWEKYAYGCSELIFQPFRYWLTRGPFTKLFRRFIASGMPLASKFTIMAYVGTYFALGTAWVLTLANYFLIGWYNGALDHYYLSSWKIWIAIVVIFSGLGNVSLAVLRYRTGEATLFRAIIENFSWVPLLMIFLGGVSLHVSQALLSHLFSVDMSWGATSKEATDTTFFAEVPNVIKKFKGTFIFCFGCIAMMIVLAIGVPYFWKIDQFIAIFPLCTVVAGHFLLPVALNPGLMRFTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M3D9L1</accession>
    <name>M3D9L1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_63030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762680.1">
        <property type="nucleotide sequence ID" value="XM_016909621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D9L1"/>
    <dbReference type="STRING" id="692275.M3D9L1"/>
    <dbReference type="GeneID" id="27906758"/>
    <dbReference type="eggNOG" id="KOG0024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_3_1"/>
    <dbReference type="OMA" id="FMTPGDI"/>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08283">
        <property type="entry name" value="FDH_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813:SF1">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="6">
        <location>
            <begin position="69"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF14559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="456" mass="50218" checksum="ADEDBDF6D0E08EFA" modified="2013-05-01" version="1">MALSQAAFKAEQALGHGDNATTAQDVTNPALDREKYGDPSGEKMQALIWNGKNKVEMMECPKPKVLESRDVILKITGSTVCGSDLHLLHGTVVELQKGDILGHEFCGIVDDMGKDVKGLNKGDRVVASFQIACGDCYFCKQKLSSQCEKTNSNTIENAMYGGRTAGMFGYSHFTGGFAGGQAEYTRVPYGDVNLLKIPDDVPDEKALYLSDVLATSWNCVVDTKVYDGDIVAVWGAGPIGQMAADFAFMNGARRVIVIDCNWRLDYIKEKYPKVETIDFTQLKGVKGGVVGKLKEMCDGRGPDVALECVAGEYPKGWLHAAEMALGLETDTSEIINEMIESVRNFGRVGVTGVYVGYTNHFNIGSLMERGIRLIGNGQAPVHLYWDDLLKKIQTGEIEPLKMVTHRVRVEDLDEVYYKFEKKEDHMQKVYVETRFSAPACAGSPALTRYTDRPLNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M3D9X7</accession>
    <name>M3D9X7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_161183</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF14880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763001.1">
        <property type="nucleotide sequence ID" value="XM_016907923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D9X7"/>
    <dbReference type="STRING" id="692275.M3D9X7"/>
    <dbReference type="GeneID" id="27905060"/>
    <dbReference type="eggNOG" id="KOG0159">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_11_1"/>
    <dbReference type="OMA" id="NICGQMP"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF237">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ATNE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="475"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="548"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="486"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="565"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="517"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF14880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="614" mass="69376" checksum="32A81D4BC1A271A1" modified="2013-05-01" version="1">MGLRQTLSLSLFFFFLYFLGGRTVVVVVVVKKSTDLLITSFFILLTTCTAYIIYQLYLHPLAIYPGPLLGKLTPAYDVYHAYIGDKHLLFYHLHIKYGPIVRFSPNSLSINHPAALQRIYSHGANVKKSRFYECFRAAPNAVSTLLATDRLQHARKRRVMGFAFSETAMKGMEGYVLGLVEEFIGRVGEVVDCAGGGEKEEEEEEGKEKWSKCLNMSQWCNWLVFDIMGELVFGKSFGTLGSHIPNRKAIFLLGRAARRNYVVAAMPALVSTGLEKFLPVLRGLYRDRCRYLAFGKQQVVKVMERQQQQSDDNKNPLKKRKDIFSLLLTAQDPDTGDNIPLPELWMESNTLIVAGSDTTSTTLAATLYYLLHNPPTLHRLRAEILATFSTRHEIRMGPKMQSCSYLRAVIDETMRMTPAVGGNLPREVLSGGLDIPELGVFLPEGVDVGVPIYAVQHHGDYVVRPFVFDPERWISSSSSSGTGGGGEKEGQEQRHHPQNRSSLQEVFTPFSIGHRSCLGKPLVYMELSLALARLIFAFDMRLSSSASSSSSSASDEYSEKHKHAQKEEKLLSERIQKEIKSGKRQPFEYQLLDWFMSRNEGPWVEFRWREKEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M3DAC1</accession>
    <name>M3DAC1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_116077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762940.1">
        <property type="nucleotide sequence ID" value="XM_016901225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DAC1"/>
    <dbReference type="GeneID" id="27898362"/>
    <dbReference type="HOGENOM" id="CLU_1012540_0_0_1"/>
    <dbReference type="OMA" id="PWWAATG"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="191"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF14819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="275" mass="25968" checksum="3E72F26981D2DBB8" modified="2013-05-01" version="1">MPPKALIKPPAKPRTSSRLAEAAAAKKSAPAASSSSSSSSSSSSSPPAAPKSKTPTRPTVPKSSVPRVESILSHLAIYRSSLNAETDPKGLLQPGILHLEAALAALRNVLPVLPGGGDNPFSPGGSPYGGSGSGGGGSGSGGGGGSGGGGGSGSTPPPPPKGTGGDVLKLKFPTKGKLPPSPPPKGKGKEPAATAAGPATSTATGPATGPATGPATGATTAAAAATTSTTTTTAPAAKPKITLTGPSGKGKKRPAPGSDSGDGQGRPAKKHKGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M3DAH9</accession>
    <name>M3DAH9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_37242</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WHI5/NRM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF14869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762990.1">
        <property type="nucleotide sequence ID" value="XM_016908665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DAH9"/>
    <dbReference type="STRING" id="692275.M3DAH9"/>
    <dbReference type="GeneID" id="27905802"/>
    <dbReference type="eggNOG" id="ENOG502S25T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105687_0_0_1"/>
    <dbReference type="OMA" id="DYTHAPS"/>
    <dbReference type="OrthoDB" id="2359117at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013734">
        <property type="entry name" value="TF_Nrm1/Whi5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08528">
        <property type="entry name" value="Whi5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="153"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="50"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="100"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="171"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF14869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="229" mass="24191" checksum="7A652139425DC5B5" modified="2013-05-01" version="1" fragment="single">MTATLDYTHAPSQSHRPDPSRAQTATTTRMQQPADTTHQHHHPPHPPTLSQPASQESIASIHSSFGGSSALSRLQGSDTNLSQLTTDTALTSPSSSADLTHATATHATPHATQTHNHVQPPRNRTPENAQCTPHLNSAADSALYSPMSITSPVATTNGAKRTASGHVKNAHSITTSPYHTTPRTAGPESRRESQSSSAGSKAGEIAATLRARLGYAMAKVQNGWEHKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M3DCG4</accession>
    <name>M3DCG4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">SNF2_N-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_80777</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763856.1">
        <property type="nucleotide sequence ID" value="XM_016910256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DCG4"/>
    <dbReference type="STRING" id="692275.M3DCG4"/>
    <dbReference type="GeneID" id="27907393"/>
    <dbReference type="eggNOG" id="KOG0385">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_17_3_1"/>
    <dbReference type="OMA" id="PNIFTDW"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005721">
        <property type="term" value="C:pericentric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006346">
        <property type="term" value="P:DNA methylation-dependent constitutive heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044027">
        <property type="term" value="P:negative regulation of gene expression via chromosomal CpG island methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031508">
        <property type="term" value="P:pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18009">
        <property type="entry name" value="DEXHc_HELLS_SMARCA6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000015">
        <property type="entry name" value="lymphoid-specific helicase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001315">
        <property type="entry name" value="SNF2 family helicase/ATPase PasG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044753">
        <property type="entry name" value="HELLS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47161">
        <property type="entry name" value="LYMPHOID-SPECIFIC HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47161:SF1">
        <property type="entry name" value="LYMPHOID-SPECIFIC HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="224"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="638"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="92"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="492"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="25"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="114"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="492"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="513"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="544"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="559"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF15735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="878" mass="98514" checksum="9D6D59059F9750B1" modified="2013-05-01" version="1">MSSDAAVSTALTPPTSPEDGPTEAMQKEEARMAEARHKEEQKREKKLAADRAKELKGGGEAVDTKYKALEYLLSQSKLYSTIMLQQMTQQEEAAEAKDEKSKKRALKREETAEKTAQAQQTRATRASATADRVSEATTKQLPRRGRPGNKTKGGGKISDYMKKEDVQAKAGQASISEALAEETKDANIQAGDIGMQDLRSARQPDLVTGGLMRTYQLEGLDWLTSLYENGLNGILADEMGLGKTLQTIAFIAFLRERGVNGPFLIAAPLSTTSNWVAEFKKWTPSIPVVLYHGSKQEREEIRRTRLRNPSSQDFPVVCTSYEICMNDRKHLAHFGWKFIIIDEGHRLKNLNCRLIRELQSYQSANRLLITGTPLQNNLTELWSLLHFLMPSIFDKLESFESWFDFSALKEKGGYEEILSKDRQKNLVTSLHAILKPFLLRRVKADVEKSLPKKREYVLYAPLTQTQRELYHEILEGNSRSYLENKIVESLSGASTPASARSRSLKRKAGSEAATPNKSAKSSRASTPATTDSVGPRSRRAKKKQQYEEVSDSRYFKQLEEEDDQMNEEDAESEDEAEVERTKTLSLAKRELANKKLQNPVMQLRQCCNSPHNFFYPFDLDDNTPVDETLVTESGKMLLLDRLLPELLQRGHKILIFSQFKTQLDLLETYCSELRGWATSRIDGSVAQTDRQQQILDFNDPKSDTNIFLLSTRAGGQGINLAAADTVLLFDSDWNPQQDLQAQDRAHRIGQTRPVIVYRFATKGTVEQQLLESADSKRRLEKLVIQKGRFRSNVGGGGGSGGGADFAELQKLLQRDDGERIDVADGKGLLSDRDLAILTDRSEEAFERAEKGIDVIGDVFKAVETKRNGEGGLLESLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M3DCK2</accession>
    <name>M3DCK2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cupin 2 conserved barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_147560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763886.1">
        <property type="nucleotide sequence ID" value="XM_016904380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DCK2"/>
    <dbReference type="STRING" id="692275.M3DCK2"/>
    <dbReference type="GeneID" id="27901517"/>
    <dbReference type="eggNOG" id="ENOG502SJU9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089363_0_0_1"/>
    <dbReference type="OMA" id="AWADPCK"/>
    <dbReference type="OrthoDB" id="9976870at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF15765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="24838" checksum="0788E2DE78F57C0C" modified="2013-05-01" version="1" fragment="single">MISFLRAPHPPKTTQAHQEITTYENGTSSVQYHPRGSKYMMTHTLPPSDPKEGPSIVQPPFHYHIYQTETFNVVEGEAHLFFGLDPLPSAVLSAKGPSAMAVLGPMRYHRFENASKTEPLKINIQLDPEDYENESRFFRNFFGYLSDCKQAGQSPSIFQLFVFLWSADTPLAIPMPFGLESLGVYLSWLLMIVVAYIGYYGLGYKTSYPEYYDEKKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M3DCX5</accession>
    <name>M3DCX5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sulfate_transp-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_147491</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763790.1">
        <property type="nucleotide sequence ID" value="XM_016904333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DCX5"/>
    <dbReference type="STRING" id="692275.M3DCX5"/>
    <dbReference type="GeneID" id="27901470"/>
    <dbReference type="eggNOG" id="KOG0236">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003182_10_0_1"/>
    <dbReference type="OMA" id="TGPMSVT"/>
    <dbReference type="OrthoDB" id="427213at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="553"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="593"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="649"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="7">
        <location>
            <begin position="708"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="853"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="17"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF15669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="926" mass="100762" checksum="53F4A0DD7540D1E5" modified="2013-05-01" version="1">MASQPSHPPSPVGDSDGSAGRGPTTSSPTSGPASPSSPRQPSYQQHRPNQPSQLRLSHMPSTSPEDRRAQSGLEADGIHPHDHEPAAVADTDATHQQGLIEGVEEGPNAATALLERANKDGDYTIRPRQGRGYGSFASTYAETVNSFDQNRPSLGGRYNTADDVDTRPNSALEALPDSVTEGLLGKSKARGTTSWLRRRAGIKNKRLMYIHYYIPFTNWIRQYRWRFLKGDLVAAITMASFYVPMALSYASNLGHMPPINGLYAFVFNPFLYAILGTCPQMIVGPEAAGSLLTGSVVSEAIKAGHIRDDDGVKAAQVGGMVTGMAGAFILVAGLLRLGFLDSVLSRPFLRGFISSIGLVIFINQLLPEMGLDEAAENSARAHGSPLDALLFISEHRHQIHKLTAAISFGAVAVILFLRELKRRLQPLPKLSWVVYVPDRFIIVVLSAVFAWRYDWQGRGVDILGDIRPPAGVKLFEPHWPFAADNFEHVSDAFETAFIVALLGFFESCVAAKSLGNGNVKTEIVKRERKDGTVEEVEESDGIRGINVSSNRELVALGVANIVGGAFMALPAFGGYGRSKINASTGGRTPMSSILLSLITVLCTVFLLPYFYFIPKGVLSAMITVVSISLLEEAPHDIIFFWKIGGYIELFLMLLVFLTTFFWSLRGGIIVGIIFSLIRLMKHATRPRVQILGRVPGTREFENAEVLAQEGHIEMVPHSLIVKIPEPLTFANTGSLKDRLKRLEDHGTAYAHPALPSVRGKEHNKNVVFDIHGVTGMDYAAAQVLVEIVRDYIDRGTAVYFCRIPSKKSKVWKLFEKSGIVDLCGGEHNFYRSVDAALRATEKRGMGTFQDYLQDESARGGGGGGSSSRNVVDEDGSASSSVTRLIDGTRTPPYFDGPSFTQDEGGPSLRKARVDGEADVEGGFSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M3DEF1</accession>
    <name>M3DEF1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Exosome complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_147816</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for exosome-dependent processing of pre-rRNA and small nucleolar RNA (snRNA) precursors. Involved in processing of 35S pre-rRNA at the A0, A1 and A2 sites.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the C1D family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064339_3_0_1"/>
    <dbReference type="OMA" id="LRTQGHN"/>
    <dbReference type="OrthoDB" id="1421013at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011082">
        <property type="entry name" value="Exosome-assoc_fac/DNA_repair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007146">
        <property type="entry name" value="Sas10/Utp3/C1D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15341:SF3">
        <property type="entry name" value="NUCLEAR NUCLEIC ACID-BINDING PROTEIN C1D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15341">
        <property type="entry name" value="SUN-COR STEROID HORMONE RECEPTOR CO-REPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04000">
        <property type="entry name" value="Sas10_Utp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="116"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
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            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="148"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="187"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF16180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="203" mass="22413" checksum="74607F4585F04DC4" modified="2013-05-01" version="1">MESIQPQIEDLTTNIDELESALLPIIKTALSSTTSKLPLLDKAKLYVLATYAIESILFSYLRLHGVDAKAHPVFQELTRVKEYFNKIKTAETAGVGSKNKLDTSAAGRFIKHGLSGNEKYDAERKERQEREKAGAKRKLESMSTGTHTRFDGAAKRIKAAEEGGETIVVVKASEVDDESPEKESTPKTKKSKKAKRKSNSKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M3DEU0</accession>
    <name>M3DEU0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_131594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EMF16034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016902435.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="27899572"/>
    <dbReference type="HOGENOM" id="CLU_1125127_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF16034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="247" mass="28371" checksum="865018268A820065" modified="2013-05-01" version="1">MESPQFLCLKKSHLGIMASRVRDRLVSGMNAYVSHSQRSQAKPTLASRPSNSAQEKNSLLRGRLRPILLPHQNSTQPTSRTGARGNVPENNSEVKYSIYPEPRFARITWKETLKNCLHVLTFFSIHRKKQWTRRKWQHGFPSGGCSRGNRQSNLPRLSMGNFYLSPCANMIPFAVWVSSSCFLIPWKFLPRAMRKQESSLMVLPYFSQTVVPAGKRLVLAHTKMGLCAWCPHFSLISWYGHSRYSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1QD80</accession>
    <name>N1QD80_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_71755</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757346.1">
        <property type="nucleotide sequence ID" value="XM_016909953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QD80"/>
    <dbReference type="STRING" id="692275.N1QD80"/>
    <dbReference type="GeneID" id="27907090"/>
    <dbReference type="eggNOG" id="KOG3764">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OMA" id="FGWCVDR"/>
    <dbReference type="OrthoDB" id="5086884at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17325">
        <property type="entry name" value="MFS_MdtG_SLC18_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF37">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="399"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="444"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="482"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="39"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="233"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="233"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF09225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="520" mass="55175" checksum="E5887D2BE8B184D0" modified="2013-06-26" version="1">MTGKTSSLAKALNTLQIPGYQNYAVEPAGLQWRSNTLFIVATVAVGLFTDLFLYGLVVPVLPFMLQDRVGVPEDQVQSLTSGLLAAYAAASVVFSPVAGILADKVATRQAPFLFGLLALLASTVLLFLGTSVPVLALARILQGISAAFVWTIGLALCLETVGPENLGKTIGSIFSFIAVGNLAAPILGGVLYEKTGIVGVFALGASMLAVDFIMRLLVIEKKVANKYYADDPSTVSDLNTSRGRDTTSGQDQDTEAQGDSQGNGEETPLLGLAGKHPDDAYYKLEPREHYATIAQYVPILPCLADPMLVTALLVAMVQAILLGSFDSTIPTVAKQLFDFSSLRSGLLFIPLGVFDFILGPIFGWCVDRYGTKPVAVLSYAFLVPVLACLRIPHEGGTDQIIIYAVLLALCGIGLAGIGAPSIVEAGAIVQKYYDVNPDYFGANGPYAQLYGMSNMVFSFGLAVGPELAGELKQVIGYGNMNAVLAAVCLSTSILCFVFIGGKPQVLRRQNRNTHLSRKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1QD81</accession>
    <name>N1QD81_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DUF1716-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_151324</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016906742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QD81"/>
    <dbReference type="STRING" id="692275.N1QD81"/>
    <dbReference type="GeneID" id="27903879"/>
    <dbReference type="eggNOG" id="KOG2734">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017098_0_0_1"/>
    <dbReference type="OMA" id="TDWREQE"/>
    <dbReference type="OrthoDB" id="1898821at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="Beta-catenin-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039678">
        <property type="entry name" value="CTNNBL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013180">
        <property type="entry name" value="CTNNBL1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14978:SF0">
        <property type="entry name" value="BETA-CATENIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14978">
        <property type="entry name" value="BETA-CATENIN-LIKE PROTEIN 1 NUCLEAR ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08216">
        <property type="entry name" value="CTNNBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01156">
        <property type="entry name" value="DUF1716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Beta-catenin-like protein 1 N-terminal" evidence="7">
        <location>
            <begin position="90"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF09216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="595" mass="66176" checksum="ED706ECFAA074F6F" modified="2013-06-26" version="1">MASSIDDLFRRPNLPPASNKRKYEASDAQEVYKSTKLTKSSSPNGHTNGASVKDGNEDDNDDDEMEAGPELPPDDDEGDDEDGNFFGSGMTQSATEALDYIDQADGPEEALQEEKIDSVWLRRLTNSFEKKVTRNAELRAKYEGDPAKFIDSEADLDAEIKSWSLLGEHPELYAEFAAEGGAAASLVGLLAHENTDIAIGAIQILAELLDEDVQAEQEQWDALVAALLDADLLELLMSNLGRLDEENESDRSGLYHSLEVLESLAGQQAIAEKIGQEKVLMWLCNRIKVVEKPVGQNKQYAAEVLQVLLQSSPLLRRRLIVDIDGVDLFLQLLAAYRKRDPAKDTPEEEYVENLFDALTCAVDEAEGKTKFVEAEGVELCLIMLKEGTKNITQRALRVLDHATNGQGIAPAMVCDKIVEAAGLKPLFSAYMKGKDAANTEHLLGIFSALLRLLPGDSAARIRVLAKFTEKDNEKVMKLIKLRKDYASRVSKVDKEIAQEQRSLTDEEMEERIDDWFSRRLDGGLFCVQMCDVILAWLVAEDQQIRELMLQEFHGGFGMIKASLDEQMRGLGGGSEEEHDTREMLETLIGFLDEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1QD86</accession>
    <name>N1QD86_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Molybdopterin binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_151341</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757361.1">
        <property type="nucleotide sequence ID" value="XM_016906752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QD86"/>
    <dbReference type="STRING" id="692275.N1QD86"/>
    <dbReference type="GeneID" id="27903889"/>
    <dbReference type="eggNOG" id="KOG2644">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030805_0_0_1"/>
    <dbReference type="OMA" id="MARMPRG"/>
    <dbReference type="OrthoDB" id="448496at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047884">
        <property type="term" value="F:FAD diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042726">
        <property type="term" value="P:flavin-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00885">
        <property type="entry name" value="cinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="entry name" value="MoaB/Mog-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056596">
        <property type="entry name" value="FLAD1_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47675">
        <property type="entry name" value="MOLYBDOPTERIN BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47675:SF1">
        <property type="entry name" value="MOLYBDOPTERIN BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24102">
        <property type="entry name" value="FLAD1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="Molybdenum cofactor biosynthesis proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoaB/Mog" evidence="2">
        <location>
            <begin position="63"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF09240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="339" mass="37424" checksum="D9773D0969B8253E" modified="2013-06-26" version="1">MFARVSQLTRHLSRPLPNYLHNSAAAATSATSPTSPLAPPNTITTMSSTTTTSRSPRQIHTAACLIIGDEVLGGKTVDTNSAWFAKYCFSLGINLKRIEVISDEESEIIEATRRMSSSYDFVVTSGGIGPTHDDITYQSISRAFNLPLVLHEEAYKKMKAFSKPDKHTGKVFDWTQDSPQKRAKLRMVELPYDKNLPDEEQVIFSAEDLWVPIAVVNGNIHILPGIPRLFEKMLMGLKPKLLPRLTDPEGKGVHRILISTPLPESEIAEFLTQMAEKVAAKGVKVGSYPRWGKSRNTVTLVGKDKDFMEGLVEEVEKGVQGNRIEVEGEDDDGGSDKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDX5</accession>
    <name>N1QDX5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ARM repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_69504</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758526.1">
        <property type="nucleotide sequence ID" value="XM_016909864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QDX5"/>
    <dbReference type="STRING" id="692275.N1QDX5"/>
    <dbReference type="GeneID" id="27907001"/>
    <dbReference type="eggNOG" id="KOG4524">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005544_0_0_1"/>
    <dbReference type="OMA" id="PHPKKPW"/>
    <dbReference type="OrthoDB" id="49511at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052587">
        <property type="entry name" value="TELO2-interacting_protein_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057567">
        <property type="entry name" value="TPR_TTI1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057566">
        <property type="entry name" value="TPR_TTI1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049362">
        <property type="entry name" value="TTI1_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18460">
        <property type="entry name" value="TEL2 INTERACTING PROTEIN 1 TTI1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18460:SF3">
        <property type="entry name" value="TELO2-INTERACTING PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24181">
        <property type="entry name" value="TPR_TTI1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24173">
        <property type="entry name" value="TPR_TTI1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21547">
        <property type="entry name" value="TTI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TTI1 N-terminal TPR" evidence="2">
        <location>
            <begin position="8"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="TTI1 C-terminal TPR" evidence="3">
        <location>
            <begin position="749"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="731"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="753"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="770"/>
            <end position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF10405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1029" mass="113605" checksum="5B86324EA7B562B9" modified="2013-06-26" version="1">MDRRNQIFQRLKPPCVALSQAALALNGPQGNVQQITEKLDELKKTLQSIISTNGRPASLDSKLADYVFFPLSQVLKASQRVSIRSLELALQCLAVLLEHGWRSHIPPPLAIQVTILCTLMAEEKPKGLVSAESTDELRASALHCLRHLFEAAGHTVDLKDAITAEANVPQLGQTISTILDAILAGASVETQTAGSDALRALMQRVATRDIQAGFLPGIVSKLTKILTPRTTQRRNHNVLILALNTLDSLFKNVLNDTFTAQILAPTAAPNGEVSQSLSKVVDQKWLGTAASQLKPAITSIVKLRGHDRYDVKKALAQWCTIKLQLEALISQESSLLALLQSTLHEWLTSLPISMQAAGEEMKIQRVQQVRTAYSIIASSGANTSLIDKLLAGVLRDSVVVALQAPTAQISDAPVVSQVQSLELAVLDSARQSTVFPSPLVRYRAQENTMKTIEHLVQNISISSAFSDDLSRSLRQTVGDAQIATFWLLLNVTQTSLQGREGMDDFLELDTNDPVLAAELLEDMYSFSLEVLTDSSDDPVDPRLQALALRALALRSQTAGEDFRHELIDALYPVLHSLATPDASLQQDSITTLNIFTSSCAYSSVQNLIVENVDYLTNAVSLRLNAFDVSPQAPQVLLMMVRLAGASLLPYLEDTIDSIFAALQDYHGYPLLVELMFRVLSVVAEEGAKAPQLAIAEGTRRELANYYDDRWQPTTIDRLATMLREQVDEQARLAEEVRSPPTCHPRRPWKQSEGGEDEQDDMQDEQEAPPVDVPDPPPPAPKTYNLLLRISELTQHFLPSASASLRASLLSLIKTTTPAIARHENSFLPLVNTLWPEIVSRLDDEEPHVVATALDIIASLCEHAGGFMRTRIQQLWPELQNIHRRVTKEILQSSQHPSQVVARRQRQMATVTSAELSLALNRMRLAPADYSDTSTRLLWTALVRVTVSITKHVSQTPEMFDDTLQMLEPMLDDEEVRTVLEEENADAVWLVMIRNGMKNPPTMPERHHAISLPYALEKGYEISTGTPISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1QE23</accession>
    <name>N1QE23_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Signal recognition particle subunit SRP72</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_150606</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the SRP72 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758646.1">
        <property type="nucleotide sequence ID" value="XM_016906285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QE23"/>
    <dbReference type="STRING" id="692275.N1QE23"/>
    <dbReference type="GeneID" id="27903422"/>
    <dbReference type="eggNOG" id="KOG2376">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013808_3_0_1"/>
    <dbReference type="OMA" id="NDMKVLA"/>
    <dbReference type="OrthoDB" id="5421607at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000512">
        <property type="entry name" value="Signal recognition particle subunit SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013699">
        <property type="entry name" value="Signal_recog_part_SRP72_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026270">
        <property type="entry name" value="SRP72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031545">
        <property type="entry name" value="SRP72_TPR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094:SF9">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08492">
        <property type="entry name" value="SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17004">
        <property type="entry name" value="SRP_TPR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038922">
        <property type="entry name" value="SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 9" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="Signal recognition particle SRP72 subunit RNA-binding" evidence="11">
        <location>
            <begin position="536"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="532"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="533"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="556"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="571"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="590"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="640"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR038922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF10525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="650" mass="70417" checksum="9277A7A94CDE93A2" modified="2013-06-26" version="1">MSLSSLASLLKQTHIRDDDEVLRAANAALKLSKNDIEAQHVKVVALLKLDRYDDAIAALNAGGEQLKGRATLEYAYALYKSGNPAAAAELAAKTPSRGHAHVEAQARYRKEDFARAAELYRQLSSDVGEDAEADLRINSGAVNAQLEWSGRGDLVEQKKPAREDLEAFETAYNAACGSIARGELGQGEVLLKRAADLCSSLEDLSEEERQAELIPIRVQQVYVLARLGREKEAEELARNLDTQSISDAVTRHIAHVNSTATTTTQNPYLVQRLVTKDLESFKPNYSFEYQSSVLRRNVYATDLQALKYAGTAKSTAETLKQHASPSTDAFYNSLSVVNAAAHAKGQTGKEALKHILPVLETRPSDLGLLLTLTQLYVSVGNPAAAISLIESFSKKLEDNEKANDARFAPGLVATKVSLYLSQGRKSSARGALAEAALHYQQRAKQGDTERPPGFTNLYKAAGKASLETDNPENLNLAKQIFEELRSTDPNDRYAAAGLLAASPETASQQDLDSLTPISRLIANIDVDALENSGVAQPPSSSVPKSLKRPAEDTKPKKAKKARKSRLPKNYDPNKKPDPERWLPLRDRSTYRPKGKKAKARQALFSQGAVASETESSRPATPGGEVVQGKQKQGGGGGGANKKKKGKGAKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1QEA5</accession>
    <name>N1QEA5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_120127</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757383.1">
        <property type="nucleotide sequence ID" value="XM_016901573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QEA5"/>
    <dbReference type="GeneID" id="27898710"/>
    <dbReference type="eggNOG" id="ENOG502TM6A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_570073_0_0_1"/>
    <dbReference type="OrthoDB" id="5421765at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="315"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF09262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="479" mass="51949" checksum="2894DABB0290F208" modified="2013-06-26" version="1">MTVSTGAAVGIAMGSLIAGILICGLVVDLLGGHRYILKKRPARGADGEDGNLEESIFGEKASRSHRGGPIDPERILSTPEQQQNSPVSSLDSSSSSIATIETLDQEVRQEFVNLNIAIKGHAELYYNLRPIEDEVALKSASCDTNLSTLDDLLGPTAPLDAIAMDSLLQTPETRHEAIRLLIAWSLFRFIQLDAPIERTLLPPELVQCAQAMSRRRQDVSSGKMMTTTTMMMMDEEAKKKRLEVTRKPLPLNSNPGSGASNRVISSPPLPHGTSTTTIAPTNAAALQEEPDNRILFAKWREISGKLFPPIHAPPHHNLSSSSPPFSSSSPPHSSSSAAAAAAAVTNPHPHTPPNETTTTTTTPHEDLITTLVCLLQPYIATGYGGARVRDLENVVAATTRLGFRLMFSSRTEWEFAWSTLMADEFVVFPALVKVGDGRGHKLRQSIVLTWEETVKLGEPVLEAVQKRASDLRNLAEQIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>N1QED8</accession>
    <name>N1QED8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycoside hydrolase family 89 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_91901</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757438.1">
        <property type="nucleotide sequence ID" value="XM_016910571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QED8"/>
    <dbReference type="STRING" id="692275.N1QED8"/>
    <dbReference type="GeneID" id="27907708"/>
    <dbReference type="eggNOG" id="KOG2233">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011988_2_1_1"/>
    <dbReference type="OMA" id="YGQPFVW"/>
    <dbReference type="OrthoDB" id="64736at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.670">
        <property type="entry name" value="N-acetyl-b-d-glucoasminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007781">
        <property type="entry name" value="NAGLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024732">
        <property type="entry name" value="NAGLU_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024240">
        <property type="entry name" value="NAGLU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024733">
        <property type="entry name" value="NAGLU_tim-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12872">
        <property type="entry name" value="ALPHA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12872:SF1">
        <property type="entry name" value="ALPHA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05089">
        <property type="entry name" value="NAGLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12972">
        <property type="entry name" value="NAGLU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12971">
        <property type="entry name" value="NAGLU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109517" evidence="2">
        <location>
            <begin position="19"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-N-acetylglucosaminidase N-terminal" evidence="4">
        <location>
            <begin position="29"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-N-acetylglucosaminidase tim-barrel" evidence="3">
        <location>
            <begin position="135"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-N-acetylglucosaminidase C-terminal" evidence="5">
        <location>
            <begin position="481"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF09317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="784" mass="88174" checksum="3327D933563541E4" modified="2013-06-26" version="1">MRFNGILVALIFALGVRSSIEFDATATAGIRSLVERRLPDYVDYFSFSLTTDNDSSIGSSTRPPNDEYTVSNGENGVIAISGNSPIALASGLRWYLANILHVDIYWFVGSNFNLIHGDLPRLNQTYHGSSIVPYRYWANTVTFSYTAAFWSWDDWQIQLDWMALRGINLPLAWVGVEKIIQDVFIEAGFTHAEVATFLSGPAFQAWNRFGNIQGSWGGGDLPQSWIDQQFELNQLIIARMIELGMTPVLPCFTGFVPTQISRLYPNASFVNGSQWNGFQAQYTNVTFLEPFDPLFTTLQKSFISKLDAAYGNVSSVYTLDQYNENDPFSGNVTYLEDVASNTIKSLKAADPEAIWFIQGWLFYSAADFWDEERIKAYLGGVEDKDMLILDLFSESQPQWQRTNSYFGKPWIWCQLHDYGGNQGLHGQVENVTMNPILALANETSTMVGIGLTMEGQEGNEIIYDILLDQAWTPEPIESAGYFDDWVTSRYHCDDAVAGLPQDLYIAWDMMRQTIYNNTDIDTAEAVTKSIFELQPNTTGLLDRTGHHSTRILYDPEILVSAWKHFYSASQETPQLWELESYRFDLVDITRQVLANAFYPLYGEFVNMTANSSLPSSSTASAEQTGARMLSLLLDLDSVLEASGNAHFSLESWIHSARLWAPTETNAADGDNMTAAAIADFYEYNARNQITLWGPGGEISDYASKQWAGLIKTYYVPRWERFVHFTLNSSTSADGQNEALKKSLTEFELGWQMEKSDSVSTPPGSQDLEQTIARVVKTWPEVFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>N1QEI4</accession>
    <name>N1QEI4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_151425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757508.1">
        <property type="nucleotide sequence ID" value="XM_016906814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QEI4"/>
    <dbReference type="GeneID" id="27903951"/>
    <dbReference type="eggNOG" id="ENOG502S7BG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_685093_0_0_1"/>
    <dbReference type="OMA" id="RDAWHTR"/>
    <dbReference type="OrthoDB" id="5286775at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="461" mass="52049" checksum="ACBF7542A396B4C8" modified="2013-06-26" version="1">MAFLKRLSDSLWNYVSPQKASKTALPTPQTGVSVTPLRKSSLDAQTARFSRSMSPTQRVLSWNSLLSSQFESPVKRKRKSKSKSKSKKRRLYTPDSDSGAHSGRQSKQPKIDVEDLDSPLGPGRGRLDSSRSDERDSFLRTPSRKSRTRSPSPSLEEYIRDDDSVASLDLDVDDDRYNDTPPRKRTVVIPKELKDKNITEEELREAGWDDDYITLIQRIGLRGREPVFPAYMKFEYRFMPDGLFAHDDEAFIGSVRNSHFKASKAIQRLFDLGGHVRDCKLIHGDEARAELEVQRHVKDYIKWAETDSGLDMQTAIPVLVQIYEEAGTPGNEFKAIAEAECRALAKRWKKALQVARSVEFSPASSRVSDGTLLSYELPTLYALVACDSIVAFMAYRADTDQCTPMAFFNYNEKDYDVWNSLALAILVCHVRNVQLRIAEDTEIGLRQPNSGESSDGMDVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1QEN8</accession>
    <name>N1QEN8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Erg28 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SEPMUDRAFT_90494</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERG28 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759067.1">
        <property type="nucleotide sequence ID" value="XM_016910532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QEN8"/>
    <dbReference type="STRING" id="692275.N1QEN8"/>
    <dbReference type="GeneID" id="27907669"/>
    <dbReference type="eggNOG" id="KOG3455">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114589_0_0_1"/>
    <dbReference type="OMA" id="NIAIWTY"/>
    <dbReference type="OrthoDB" id="6485510at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005352">
        <property type="entry name" value="Erg28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15451:SF19">
        <property type="entry name" value="ERGOSTEROL BIOSYNTHETIC PROTEIN 28 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15451">
        <property type="entry name" value="ERGOSTEROL BIOSYNTHETIC PROTEIN 28-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03694">
        <property type="entry name" value="Erg28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="11" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMF10946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="153" mass="16931" checksum="EB0630EDDC3193F6" modified="2013-06-26" version="1">MSSFLTAYLPQSEGLLPKWLLFIAIISLGNTIQCYRSLTGSQEVYSGSSSPKNKNNPSTSSSTSSSPVTPLSARTFGTWTALSSIIRLYGAYNIHDAKIYELCLWTYGIAFGHFLSEWWIFGTARWGRGLAGPVLVSTVTSLWMLVQWGSYVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>N1QF56</accession>
    <name>N1QF56_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_111172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757853.1">
        <property type="nucleotide sequence ID" value="XM_016900902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QF56"/>
    <dbReference type="GeneID" id="27898039"/>
    <dbReference type="HOGENOM" id="CLU_1489889_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="181" mass="20766" checksum="D41CE2623365EFDB" modified="2013-06-26" version="1">MSMQLLMTQSSEQVVHRPRRGNRAGASGSSGWIAPVTSLSNDFQPTGQGSPQDYPHRHTDLQEQKRQQQDALVQPDPHPDPRSAAMKRATVESMLRSRRRYGEQRRSGGGADVADEAVTAAVRQYQEMLLLERRRRMEEMEAHRRMREGDDGERKRRSRADILASTRRLCKYDDLRGEHNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1QF71</accession>
    <name>N1QF71_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_67275</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760014.1">
        <property type="nucleotide sequence ID" value="XM_016909783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QF71"/>
    <dbReference type="STRING" id="692275.N1QF71"/>
    <dbReference type="GeneID" id="27906920"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1431283_0_0_1"/>
    <dbReference type="OrthoDB" id="10018191at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000688">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF11893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="190" mass="19841" checksum="9ED288CEC95E68B4" modified="2013-06-26" version="1" fragment="single">MNPTTSARPDIATATATADDRTATAAESADESTTGEPSPKRRRSELILAGSGGGGGSGSGGGGNAGGGGVVEEEGSSSSIITGINNSLNNGIPASQRLYSCGKCSKSYTRLDHLSRHVRMHTQEKPYQCHICTKAFARADLLKRHALGHAKDDPHAKPTIVQHSRVSQACEACAGLHLKCEEEKPCKRCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1QF94</accession>
    <name>N1QF94_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GTP cyclohydrolase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_149699</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase II family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759958.1">
        <property type="nucleotide sequence ID" value="XM_016905716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QF94"/>
    <dbReference type="STRING" id="692275.N1QF94"/>
    <dbReference type="GeneID" id="27902853"/>
    <dbReference type="eggNOG" id="KOG1284">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029639_1_0_1"/>
    <dbReference type="OMA" id="FQQLMPD"/>
    <dbReference type="OrthoDB" id="57939at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="entry name" value="GTP cyclohydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022163">
        <property type="entry name" value="GTP_CH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005536">
        <property type="entry name" value="PRK07198.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47259">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47259:SF2">
        <property type="entry name" value="URACIL-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12471">
        <property type="entry name" value="GTP_CH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="RibA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GTP cyclohydrolase N-terminal" evidence="7">
        <location>
            <begin position="121"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="GTP cyclohydrolase II" evidence="6">
        <location>
            <begin position="346"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF11837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="535" mass="58859" checksum="45039426BF01801A" modified="2013-06-26" version="1">MTAIPSDMAGKLDVILEKLTKLEHGQTDLRQNHNSLSSTVESINGRVNALAGVKQAQNGIAHDASYPSPHLGPSSPKLAPQGLAERDSIGSNDALVKDANSTSTEQAASPSARRPSTVTSKIILTSYPGQAGVDPAPMEWGSRDAAKRGPVVVSRNPSTIRRRNAIGAHGGSYSIYYALAVASKQMDTDHKPDFTNTEPAADIGPFPAWYDPKKIVAMDPWGHLAPWLYNDYIKNENVEIRPTIAVTKAHMILPELAESVRKGRLVPDGKICLNESGELNVTKFAVEPTWYLPGVAERFGIDEGSLRRSLFEHTGGSYPELITRNDIKLFLPPIGGLTVYCFGDPKKMSDPNSKLALRVHDECNGSDVFGSDICTCRPYLIFGIEEAVKEAQRGGSGVVIYFRKEGRALGEVTKYLVYNARKRGSDKASEYFKRTENIAGVKDMRFQALMPDILHWLGITKIDRMLSMSNMKHDAIVEQGIPIHERVPIPDEMIPEDSRVEIDAKIHAGYFTNGKIMTVEELDNVQGRAWEDVDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFF5</accession>
    <name>N1QFF5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_71708</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757324.1">
        <property type="nucleotide sequence ID" value="XM_016909950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QFF5"/>
    <dbReference type="STRING" id="692275.N1QFF5"/>
    <dbReference type="GeneID" id="27907087"/>
    <dbReference type="eggNOG" id="ENOG502SNNB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031559_1_0_1"/>
    <dbReference type="OMA" id="REALMYH"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021838">
        <property type="entry name" value="DUF3431"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11913">
        <property type="entry name" value="DUF3431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF09203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="340" mass="39476" checksum="FE6C9A9E7B7A3C2B" modified="2013-06-26" version="1">MQHLYQPLPTGELLSPIHDAARHTRPTSGQTPLTINLVVASVASDDVSWTEELHNSIANLQIFRYVSDDPVAEYHPSIAKGREALMYFTYLYDHYESLADVNIFVHAEEHPWHLDGAMQQSMRFALSQLDLEQVMQLHYFNLYTSLKGGRPEGYNTTKTTDETDVAEEPFIAEAMRANFGEDITVPEMLIGPCCSQFAVSKEAIRSRPRSQYRHSMQWLTETDWPDQLTGRIWEHLWPWLFLHDQAVDRKTEWRTLCRMYRVCFSDSDDLQQYQAVWDERVKLLEKIGFGRELLRPWNVRKARMRLNDLLQLGRQLLLGALERGQDPEQRIVAGLDLTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFI6</accession>
    <name>N1QFI6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_143173</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758623.1">
        <property type="nucleotide sequence ID" value="XM_016903031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QFI6"/>
    <dbReference type="STRING" id="692275.N1QFI6"/>
    <dbReference type="GeneID" id="27900168"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_0_3_1"/>
    <dbReference type="OMA" id="CEPIVGF"/>
    <dbReference type="OrthoDB" id="5376138at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF3">
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    </dbReference>
    <dbReference type="Pfam" id="PF07690">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="445"/>
            <end position="467"/>
        </location>
    </feature>
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        <location>
            <begin position="33"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF10502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="506" mass="55244" checksum="8B1E541B6C45DFFD" modified="2013-06-26" version="1">MSTISSEKVVGPGADDGYKFTARAWPSWKKWTVLTGMLLVQISQNYNASVFMSAAPQLTEKFNITAATARLAQMIFLVMYAFGCELWAPFSEEFGRKWVIQTSMLLVNGFMIIVALAPSWPAVFVARALGGLSSAGGSVTLGMVADMYFPADQFQAVAFTCFGSVVGSVIPPIVGGTVVEKYSGLTCIWIAVAIGFFTQTVHLFLPETRLELLLDAGAKKLRSQDPENKVQGPQEARGTFWQRLDYVHIAKLMWRPYWLLLTEPIVLALSLLSGFSDSLIFSGLDAFGIILQKWNFTAPQVGYAFIGLLIGYLISYAIGAGHFRLNPGRKEKNNSVPEQRMWLLLVTVLGLPIGLLGWAFCSLGPAYHIPWIAALLSVTLIGVANYAIYLHTIDYLVAAYGPFAASATGGNGFCRDFLAGLAALYTVPMYENIAPGSDWQTVWPTFMLAAIGAVLVVCFYLVFMFGAKLRARSKYASNLERIREQETADAQGAVVEQASRGLSKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGA1</accession>
    <name>N1QGA1_SPHMS</name>
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        <submittedName>
            <fullName evidence="8">UPF0057-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_144365</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0057 (PMP3) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456269">
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    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGA1"/>
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    <dbReference type="GeneID" id="27900210"/>
    <dbReference type="eggNOG" id="KOG1773">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107649_0_0_1"/>
    <dbReference type="OMA" id="YPEPPYE"/>
    <dbReference type="OrthoDB" id="2802411at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000612">
        <property type="entry name" value="PMP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659">
        <property type="entry name" value="HYDROPHOBIC PROTEIN RCI2 LOW TEMPERATURE AND SALT RESPONSIVE PROTEIN LTI6 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659:SF57">
        <property type="entry name" value="PLASMA MEMBRANE PROTEOLIPID 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01679">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="145"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF09578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="157" mass="16737" checksum="943AC14C186EB0DE" modified="2013-06-26" version="1">MCGSDILLGLIAILFPPLAVWVKRGLCSADSLINILLCCLAYLPGLLHAWYIIAITPDPTYERVAQQDAERGTVTYYYVQTNGQPQYAPQGQGGQSYGTVNASAPNAQFAQQQTKPQPHPGAAAVHPSSSQAGPSGEEDAPPPSYQQATGDNKIQRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGF5</accession>
    <name>N1QGF5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_150875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016906448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGF5"/>
    <dbReference type="STRING" id="692275.N1QGF5"/>
    <dbReference type="GeneID" id="27903585"/>
    <dbReference type="eggNOG" id="ENOG502SCKF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_931173_0_0_1"/>
    <dbReference type="OMA" id="YVHHEED"/>
    <dbReference type="OrthoDB" id="5335351at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF10927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="299" mass="32264" checksum="78263FBF8428E407" modified="2013-06-26" version="1">MSSELVTGDTERLQSKANVGDDGSPPASPLSTLPSTPPVPTYTQMAASKGRSTSGDEMPPPVTRGASAKSSTAGRKRSREAVEEEQANTADGSSTAAEPLSNARGKKRGNSTDSVATAVKDSQNQSRPQHQPNGEAPSQNVPASGQGQATANAQPAKSKKVIPAQTSQPLQPVVPEQSAEGLGKEDDYESGSESSVLASEMVPEESIEDFDWSHLVQRHHDKMNELRNQDAQLMTEFNALIDYFTVWADVGNYKEFDRSCKRLNTQVAFVQHEEEQLANKRQHYIKVVDAFKSALQLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGK8</accession>
    <name>N1QGK8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRIB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_156591</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759730.1">
        <property type="nucleotide sequence ID" value="XM_016907685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGK8"/>
    <dbReference type="STRING" id="692275.N1QGK8"/>
    <dbReference type="GeneID" id="27904822"/>
    <dbReference type="eggNOG" id="ENOG502RFXM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_338891_0_0_1"/>
    <dbReference type="OMA" id="SSWEDDI"/>
    <dbReference type="OrthoDB" id="24581at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="196"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="478"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="629"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="691"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="308"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="434"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="646"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="765"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="783"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF11609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="792" mass="86139" checksum="EF108F7EF228B21F" modified="2013-06-26" version="1">MTSMPREAAASSLTDPNHYRSFDNINMAAGDPKGPTPTRPWIEKDSEPHASPAGELTRRKRLSFFGRSSSDAATRKPPMQPLQATMSTHKDELPAFDSVPQAQPRRPMTSGSDHARRKTSDQIESIRHSIFGGRKGSRPTTKRSRQSHQAPNVGLIPFTSPLQEEVTPPPEAKGNVGAKDFRDESDFYHHRKKTSISSPFNFHHVGHTDRKNLPTRLETVDEKALSNRLLDFDAQGHALQGVPADKIRHSRLLLQSTSSPHEQVIPSRHRGSPSVDETTFNEALETKFNVEEHFNERPALRSPERVPRPSSSSPALNSPSSSSASHTIPHLHTKASFDSSSQLTHSRDPSPSCEDRPTMPVRGRPLGQSFREKQPLPPVPPQEQPAAMVGQKPSKTSLASSRLSMGQRFHPASGVNAGGYPASIASQKSKRSSKSAAPTAHSSTSTRAFSDIPVGLDWEDDIDFAFEQEAEATCDFDWEKYAPFMPPTKEELPDPSPDGSSPDSSGGGGVRLSGWIDEPSALAGGEAPMNTSGLPPLFDEDGQPLHHKRGSSVGHRGFLAARNSSTDKLSAKTPPLPVEISKHAEVSTPPAISLTTDSVGFAAADEGKKSPYGMQSYFPAFDSCIPEYLSDPESTRTGGNRHRKSSSYSSFDSSGRSLQNTSASVSSMSTRWSSASTSSIPDLLHCSTYSRKRASVRKSATSGIFRTLESVPHSPDGREEPKSSVEVQARPSISDRSVSDTILMRRPATSGDRALLFQSGRVVQRGRSSTRSASRMAAPPLPQEEEQEHTWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGY2</accession>
    <name>N1QGY2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_117698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759845.1">
        <property type="nucleotide sequence ID" value="XM_016901363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGY2"/>
    <dbReference type="GeneID" id="27898500"/>
    <dbReference type="HOGENOM" id="CLU_1670483_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110828" evidence="1">
        <location>
            <begin position="25"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF11724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="158" mass="16573" checksum="A4495A69DD6C0CA0" modified="2013-06-26" version="1">MLWPIAVAAAVASSFLLSAGPASALGQLAPRQGGPTGTNDDGEPIDPNAPEISYCFCGNPENGDPDVNATVPICHQYFPGHAITARQEAPGYRPYINCEDVGEKNFNDFGEYCLEHYGLTKSNNGFGGALCCYVPPGGNYSAGYCDAFPPETPSEGSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1QH65</accession>
    <name>N1QH65_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HORMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_157709</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016907748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QH65"/>
    <dbReference type="STRING" id="692275.N1QH65"/>
    <dbReference type="GeneID" id="27904885"/>
    <dbReference type="eggNOG" id="KOG1844">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4652">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019753_0_0_1"/>
    <dbReference type="OMA" id="HACYQCL"/>
    <dbReference type="OrthoDB" id="1928087at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051598">
        <property type="term" value="P:meiotic recombination checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007130">
        <property type="term" value="P:synaptonemal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051294">
        <property type="entry name" value="HORMA_MeioticProgression"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48225">
        <property type="entry name" value="HORMA DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48225:SF7">
        <property type="entry name" value="MEIOSIS-SPECIFIC PROTEIN HOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20826">
        <property type="entry name" value="PHD_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="6">
        <location>
            <begin position="23"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF10503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="702" mass="77837" checksum="5B1AF946F896AA31" modified="2013-06-26" version="1">MATMQLQKTRMAQTKTKTAMTQKQSLEVVQTLLHGGLSSLAYLRSWFAEKAFKQQIYSAGSGGDRIPSYQAYVSGNLPKISGREDVMHTIMKVLCRKRSKRVDVFLDWLEKGVFVALKEGTLKALQVYVHTDPDDREKVVETYTFTIKYHPDGRGGRLYAGIEIDSPGKASATVEATNRSLQVLLRQIIEICNELPELPEKRFVSMALFHLENIKDFKAPGFEPSTARNLLFARTEGWEKQTRFLDDLESAFHSTSLKVSHLNQPALRAISSVAEPSRIPSILEYSSNGTREAEIPDMRDVLPDDISTVFPVGDTEVDPTTPAPTSALAIQQVEHETPPAGDPTPVQANFPAGPTLTANIDTQSSDVPNMKKALQGMMRPEYLSQGDTQTQAMQPAPVVEPSASAQLTLLPDIARQLRLNKVKLERTALNLAGVTRRNSKDSDILLCQCGDREEEGDMINCSFCGTWQHLHCYGFTGSADPRMPEDHACYQCLLSGHEEQLQSKMKDLAQKRRAMSFALQHVLRLTNEELAKSMDISISTAKTILNYFVAEGFVTTPSGTHRNSFPVPNKPYFVPVQEGPTYDKLQQELFDPLRHINSFYANVPTTLSTTVARQLRSLRAMSMPPAATPASPSRKRAIATPVPALSAHPHLAKRPTDDVPQSDDIFSTPAKRQARATPIYRRFRSVQTTAILNADGLSSPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1QHF8</accession>
    <name>N1QHF8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_143246</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_016758709.1">
        <property type="nucleotide sequence ID" value="XM_016903036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QHF8"/>
    <dbReference type="STRING" id="692275.N1QHF8"/>
    <dbReference type="GeneID" id="27900173"/>
    <dbReference type="eggNOG" id="ENOG502RV97">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042524_0_0_1"/>
    <dbReference type="OMA" id="YMAGQFQ"/>
    <dbReference type="OrthoDB" id="6020543at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42972:SF8">
        <property type="entry name" value="POLYHYDROXYBUTYRATE DEPOLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42972">
        <property type="entry name" value="TOL-PAL SYSTEM PROTEIN TOLB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF10588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="342" mass="37301" checksum="3A1E7CC2C40174DF" modified="2013-06-26" version="1">MYNIDPSAITVSGFSAGGFMAAQLGIAYSSIFSGFAVFAGGPYDCARDQDFYTSCMGNHTPSIEKPIAHIQQWSLEGQIDPIEHLRSSKVYLQTGALDEVVASSVMRQLEKQLYAFIPAEEITFVELEHAAHVFPTDFDPSGSQSSQCTDSISPYIANCNYDGVGEMLKWLYGTDTIQPRRNSGPLTGTLHEYAQENSTGAIGLAHFGYYYIPSSCNFSSSSSSSSIPCKLHIALHGCTMSVSHISYKFILDTGYVQYADSNHIILLFPQAAAVAQEGDHNNNNNNNNNITSRPIWYPNGTEYPGAALACFDWVGWSGENADWRGGVQMEAIVRMVDVQTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>N1QHH7</accession>
    <name>N1QHH7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 16">Branchpoint-bridging protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">SEPMUDRAFT_152816</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 16">Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the BBP/SF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764766.1">
        <property type="nucleotide sequence ID" value="XM_016907486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QHH7"/>
    <dbReference type="STRING" id="692275.N1QHH7"/>
    <dbReference type="GeneID" id="27904623"/>
    <dbReference type="eggNOG" id="KOG0119">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016864_3_0_1"/>
    <dbReference type="OMA" id="PGMPSMY"/>
    <dbReference type="OrthoDB" id="6777263at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000243">
        <property type="term" value="C:commitment complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045131">
        <property type="term" value="F:pre-mRNA branch point binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02395">
        <property type="entry name" value="KH-I_BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.60.10:FF:000030">
        <property type="entry name" value="Branchpoint-bridging protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000024">
        <property type="entry name" value="Branchpoint-bridging protein-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045071">
        <property type="entry name" value="BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032570">
        <property type="entry name" value="SF1-HH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047086">
        <property type="entry name" value="SF1-HH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208">
        <property type="entry name" value="RNA-BINDING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208:SF45">
        <property type="entry name" value="SPLICING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16275">
        <property type="entry name" value="SF1-HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 16" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11 16" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="12 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 16" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="9 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 14 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="19">
        <location>
            <begin position="303"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="19">
        <location>
            <begin position="328"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="397"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="249"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="397"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="415"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="438"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="462"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="494"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="514"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00053279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EMF16645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="538" mass="57806" checksum="11C482400C0DE37C" modified="2013-06-26" version="1">MSWRAVGQTGANTIPLGPRRKFGDEDGPEGDTEPPREMKRGRSPEPRTKTVELNPDGTKKRRKRNRWGDASDNKAAGLMNLPTAITAAMTAEQLDAYVTHLRIEEISQKLRINDVVPADGDRSPSPPPQYDNFGRRVNTREYRYRKRLEDERHKLIEKAMKIIPSYHPPSDYRRPTKTQEKVYVPVNDYPEINFIGLLIGPRGNTLKKMETQSGAKIAIRGKGSVKEGKGKSDAAHASNQDEDLHCLIMADTEEKVNKAKELIHNVIETAASIPEGQNELKRNQLRELAALNGTLRDDENQACQNCGEIGHRKYDCPQQRNFTANIICRVCGNAGHMARDCPDRQRGNFGRDLPPRAPQNAIEGDYEKLMNEIGGGGAPALDTSVPQRQIGYEAGAADANGGARPAAPWQRGPTGAAAPWQQPRQGGGGPAPWENRGGNDGGYGNGGGYGGPTGAPAPWANRGGGAHSGGGGGAHSGGGGGGAAPWQQPPSQPAPWQQPQQAPWQQPSGGYDAVPPPPPADLPPPPPPSDVPPPPPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>N1QI79</accession>
    <name>N1QI79_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_108940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760270.1">
        <property type="nucleotide sequence ID" value="XM_016900754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QI79"/>
    <dbReference type="GeneID" id="27897891"/>
    <dbReference type="HOGENOM" id="CLU_860979_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF12149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="323" mass="35231" checksum="FE751858DFB7B03A" modified="2013-06-26" version="1">MKRPQQTLVLHSKLVSSLALGASFTEMGAQHSRLQKRSLRRSIRSIPYATTAVAVIPVSRPDTVRSKRTSILRPLSQGVDRETAEALLSETLQITVDLQQVHQQLNDILRTQDAGQRAEVPERREPHRPLLPQFSFEQRPPLPLWPFTRPSCRASRPENPMIIGQQSSSNLLSPIAEHHSRSQSPSRLNVPNSSRSRSPNRFSSTSSFYSTTSRTADDVLEILPSLTASSSCYSLIDSPIQSQWASISMATSPTSTNEGFGQHESILGPAVALCNELLADSAGSLVGAREVTLDVHQHGGGLGKPLTISVAKHDNTIIITKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1QIP3</accession>
    <name>N1QIP3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TPR_MLP1_2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_150555</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758575.1">
        <property type="nucleotide sequence ID" value="XM_016906256.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.N1QIP3"/>
    <dbReference type="GeneID" id="27903393"/>
    <dbReference type="eggNOG" id="KOG4674">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001250_0_0_1"/>
    <dbReference type="OMA" id="HAQQNYE"/>
    <dbReference type="OrthoDB" id="343070at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057974">
        <property type="entry name" value="NUA/TPR/MLP1-2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012929">
        <property type="entry name" value="Nucleoprot-TPR/MLP1-2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057577">
        <property type="entry name" value="Nucleoprot-TPR/MLP1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18898:SF2">
        <property type="entry name" value="NUCLEOPROTEIN TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18898">
        <property type="entry name" value="NUCLEOPROTEIN TPR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25481">
        <property type="entry name" value="Nucleoprot-TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25785">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07926">
        <property type="entry name" value="TPR_MLP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoprotein TPR/MPL1" evidence="7">
        <location>
            <begin position="191"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="NUA/TPR/MLP1-2-like" evidence="8">
        <location>
            <begin position="488"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoprotein TPR/MLP1-2" evidence="6">
        <location>
            <begin position="1081"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="367"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="662"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="945"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1285"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1529"/>
            <end position="1551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1851"/>
            <end position="1871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1949"/>
            <end position="2130"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="80"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="164"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="425"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="607"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="708"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="984"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1470"/>
            <end position="1525"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1559"/>
            <end position="1696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="385"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1285"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1532"/>
            <end position="1543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1857"/>
            <end position="1871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1960"/>
            <end position="1972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1986"/>
            <end position="2001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="2038"/>
            <end position="2049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="2051"/>
            <end position="2065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="2075"/>
            <end position="2091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="2092"/>
            <end position="2104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF10454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="2130" mass="236322" checksum="9C2836D5717A8A40" modified="2013-06-26" version="1">MRTRAQAHDPATLDVSYVATTFGVAEHDVQQLLDAPTAELVEDFLLSLTDKGQEFDALRAEKLKVDVELDNTVRTSDAKVKAQKSAVAKAHKEVEDLRTKLDQSEAAREALAAELTQLKSSSSGSSAEAQALRQRIDTIEASNRDALALVESKSTEKDRVAADLSEQHAKLLGLRREINQLEEKNSALENAAASQKFKEQSLQQEIDLLKKSNEWHANELQTRSQEHAKFRKERNARISTLERDLEDSSATVDALKRTEATLRQRLDELQGKADEAFARIASLQEEYARKEQDFRAELSGSKRLAELQAQNAATHKKRLHEVQVQVDQIKEDAAEEIGRLQAEIETERGDKEIAESKVAELELTVERLEQQPRMSRPGTPLRNGEPQTPGRTGSPSAMPGSMRKVVNGLSFTQLYSRYTEAQEDLESERRRTNKLSTALDELVNELETRKPELEDLKEEQERLENEVLDFSRLLDEANAGKDGAIRELERWQGEANSAARESQILRQQLRDLSAQVKILLVEIQSRDQGLGELSADERLELERAARGELDDGTLDELSSTGRLISERLVIFRQVADLQTQNEKLLRLTRELGDQMEGNEAKEKARQSEADAQEVEVLRQQIERYKDELTSTTSQIDSYMKERDMFRRMLQHRGQLAPDADMQSLFGQSVGPGTPSRNSQGPPATPRSKDEDDLRKLLKEHQTYFDQFRNESTTDRRMLKEQADALTREKSTLQADLARAQSQLTLASERYEMLQSNFSALRNENGELQKRSQQLGEQAARQDLRTQQVAEELVEARSMTESLRNENANAKAEKELFKRIETRLHEENKTLLDDRSRLNKLVTDLQNLQNERELQESDNRRRLQSRVEALETELNDTKKKLDSEVEDSRKAALRREYEEGQSRTRIDDLVKSLGHVREELVAAKTNRDQLQSRVDELKIELRAAEEKVTALQPRPTPRAEPSSSGTPRNADEEDLPAEQRLAVQVSELRRDLELQKGELESARTQVEQYQAIAQASEEELSNLSTTADQYKEDTDNLIAEKDAKIAQLEQRIEDIGSELGTTNSELSELRGKADDSGRQLAEQKANYEAELSRLKDEVERLETNAITIQDDVKTQAEIAQEAQTSYEVELQKHAEAAKSLASVRNEYNELKTKVAGARAEAEAAKSSLERSEESWAEQREHFERELEEAKRKRQDVDEQNKLLHQQLESFSKELTALRQGRSAAAATPAADGEGSDVAASGGSNLQEVINFLRREKEIVDTQYELSSQEAKRLQQQLEYANTQLEETRQKLSDERRQSVEKASAESSTSKLMQTINELNVYRESATTLRNEARQARESLEEKSLEIERLLAETQPLKGRLRELEGELEVKQDEIKLLQDDRDHWRDRTQNIISKYDRVDPAELEEMKKKLEELQAEKERLEAEQVPMQEQIDGFEARLQSEKEAATTPLNDRLNKFREQAKSQDANRRTKINELNLEKNALIAEKDGMANELQQVQSQLASVSAELEQAKTEISQTQAALEEARINAAKSISDDAEEGQVEEDGTASGTDNKNAALYNKIAEAESQASEHASRADGLNAQVQTLQARVQELESQVGEVQQQLETAQANSGDGSTMPTSDNSEALERLQQDLAIAQQEVEALRANAADPPTETLVNAEPMAGEKSVADQVAEEVARQRAELEQQYELSKSQVDEQAQLRVDAVKAEFQQKIQEEKVKIRGDIEQELRAEHEAVIRKLTEEHAATIEKLQAGHQAELERFNADGAAAVEKAEALSPVKPKTEGPPVAAAGALDVKALNLTYEQATELIRSDKQIKELLTKSVKTHVEKQTAKLREIIAAKDAEITKLQEELSKLPAATNPAESSQPPSTEADTLARQQLEQQLATAKSELDAANIAKDVAVKHAVETAEKKFKLQLNMRDVAVAKVTAVQKAAQETPEKPVKEVWDIASKARPPPVAKPALPSATQPAPTSTFGQPSKPPVVAATPTNPQAASSTPSVAPASRPGSESGSSANAKPANGTGPAALKSISSIPSAAGATKLPGPGARAGTGPPSRQGSVGSTPAPNALQQRGGLSSGLPRGGGSLPRGGARGGSIRGNARGGNAANAGQKRAHDGTEPAGTDPKRTRGGAAGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJF8</accession>
    <name>N1QJF8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2293 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_130128</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765487.1">
        <property type="nucleotide sequence ID" value="XM_016902338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJF8"/>
    <dbReference type="GeneID" id="27899475"/>
    <dbReference type="eggNOG" id="ENOG502RKJU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1651828_0_0_1"/>
    <dbReference type="OMA" id="REWCPWD"/>
    <dbReference type="OrthoDB" id="5381833at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018744">
        <property type="entry name" value="DUF2293"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10056">
        <property type="entry name" value="DUF2293"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2293" evidence="2">
        <location>
            <begin position="35"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF17366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="164" mass="19817" checksum="7C7AA2BE9A3645D2" modified="2013-06-26" version="1">MPQQQQQEQQQQQQQQNLPLSSQLARKREWNRGPLTDLFPRLPDFILERLLDLIISKGFTYNLSHSKLSNAKRYTAIVIAHCRHAHSDYDQLLLRDRLERFEARRRTAERVWKVLREWSPWERDNEVLERCFRATLVPPEERDESWDPMDVDEESDFEDPMDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJY7</accession>
    <name>N1QJY7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Caffeine-induced death protein Cid2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_160761</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIX23 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765636.1">
        <property type="nucleotide sequence ID" value="XM_016907906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJY7"/>
    <dbReference type="GeneID" id="27905043"/>
    <dbReference type="eggNOG" id="ENOG502S21A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081050_1_0_1"/>
    <dbReference type="OMA" id="QFCFNER"/>
    <dbReference type="OrthoDB" id="5593818at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019171">
        <property type="entry name" value="MIX23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016805">
        <property type="entry name" value="MIX23_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31905">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31905:SF2">
        <property type="entry name" value="PROTEIN MIX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09774">
        <property type="entry name" value="MIX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF022603">
        <property type="entry name" value="UCP022603"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF17515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="23444" checksum="FF5CC7DB5B630875" modified="2013-06-26" version="1">MSSSPPVAPPPRLTPQFCFNQTALRDFLRISRSAIDDTITQNLNALVTPSANPFDSSSTTMTTMGRHQRPMGRRAMIDSTTCQTFQDRVLFPSWQSRSDVLNYCAGVATSPDPDDPDHMLRETEDARARERIVDERLDPYSARYFPRDTRTESLAGLVRNERMVETIIRSRTWNLVGERCENETADADKALDDWRRRMGTSPDKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKG2</accession>
    <name>N1QKG2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_149606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759812.1">
        <property type="nucleotide sequence ID" value="XM_016905656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QKG2"/>
    <dbReference type="STRING" id="692275.N1QKG2"/>
    <dbReference type="GeneID" id="27902793"/>
    <dbReference type="eggNOG" id="ENOG502RM0K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025005_3_0_1"/>
    <dbReference type="OMA" id="LEEYWAI"/>
    <dbReference type="OrthoDB" id="3645574at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF37">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="554"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF11691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="657" mass="74940" checksum="20B30D1A50070917" modified="2013-06-26" version="1">MFLGKQYPSATYAEVVADDHNMLVEVQWPRQKRAFLEYLQRESSAIEQAVRYHLSLSSRALCTVAPLREWRGGSFNMMIPVTVRPQGNKHHHDTDGGYRVAVRCPWPHRMHSQTSPDMAAEKVRGEAATYAWLSAHVPSVPIPQLRGFGLSDGRAFTPLVCCSWIRRAYESLRQRLQRLFLFFSASASASASSSSAAAEYWRPFFPSMGPVQLQTGYFITDFVERRQGRMLHELWPPREPADRQKMFRSLSRLLLDLIEIPLPRIGSFTVHDSGEVTLSGRPLTVPLAMLENEAIPSEIPPNTTYTCVETYLEDLLHCHDTRMEHQLNAVEGFYDAEGQLGTIVAWKAIRSHFMDRSLRNGPFALQLTDLHQSNIFVDDQYNITAIIDLEWTCSLPLEMLQPPFWLSGHIQDSFVGASEKVITNEKAFIPASREFLDIFGEEQKSRNPSRKLPFNAESVIRAAFEKKSHWYFAGLKYPRVTYSFLTLHIIPIFAPVDLFPRHVYEFDPIFARYYTADASQFVDKKVKEKKQYDEALLELFPEEKKKAEAKKAEEKKAEEEKAKEEKAEEGKAEEGKAEEGKAEEKSVEEKTAEGKSVEEETAAEKTSEENNIEEKNAGEKNVEEKNAGEKNTEEKNAGKNAEEKNVEEKKAEEKNAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKK5</accession>
    <name>N1QKK5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_157106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760436.1">
        <property type="nucleotide sequence ID" value="XM_016907718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QKK5"/>
    <dbReference type="GeneID" id="27904855"/>
    <dbReference type="eggNOG" id="ENOG502T8A2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_278389_0_0_1"/>
    <dbReference type="OrthoDB" id="3899138at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="729"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1042"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="368"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="585"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="747"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="778"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="799"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="872"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="891"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="935"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1042"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1052"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1082"/>
            <end position="1095"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF12315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1136" mass="124264" checksum="EF15411AB9A4CA7A" modified="2013-06-26" version="1">MAATKLMNCTGDFVHPLGLHPPSPQFLPGSELQPDSISDGYAMECNPTELWTVESNIDSYVDDRCPTEWEHPPSLQSPQSPESFAWSPSGLVPRPIDALNITDESRVVPEGVAARFATRELNALRDDSLTALPRSPTDETPRSSKLKTLDSALLRKLFKATIDEKRRIDESMRQKSQDVSAKVTAKAGVEARSRRVVEQGSPTMPDDHEVVRGLMKSLSGRLPGIASEQLPPVSETKSESAKHRSSQDSQRSSPGGYSRRGSLDTVKLRRIAGKNGKEAFAAMPRRLPSFSSVKSSNVRALATTKEEVQVKVVSDRLQDLPGHGRKKLEARDARIKQRDSCIVDLQNFLRETGPIEIDSPVIDKPKSSKPSKQQQQQQPKDKIERIKKTATAAKDIFLSPLGPNVQQAPSASHDATAPQEISISKRRGDLAHMQATVESTTSQTCSDVLAEVTEGPRQDIERDWAQVTPQKQNTSTPGLHRTGRSVDPTTSPIAVKMSPRPGLPKLAIKIPGSSGWKEISYTQDMSSPSARAKSPATAISPTISKQSVPNNVRQQDADAQSDEEEDDAKAEDARSDEEYGEGDQVDDREIEAVKPPMERKDSKTASLHAEPAAHNTPSQKGSSYWFRDYTSPMSKAFEFRPVEGTSSNTPPLRTPQAASKQIQGVVEGWVQEAHESRSLKLAAAKQVLRAPRSPVVVSRSRGLSRPSTSRGFRERPDEWMFLAQNAGASPAGALNDASRHAYRRSRSAASSQRFTALSLHTQEEVGQGVVNEDERKSTAWAAASSRSTKVPIKSMSFKSVPPSRAQSRPSSRAQSRCSSVAPPISPQKGWAGASQGWQPAEEQSMDSWPEYPDLDHISKFSTAEQSRRRPSLPSTHRSQKFQGASIQSLNSRKSSGASHHSSTTSCPQSIHEESECNSLVSQQLDEPPMPALPESSHHVLADEPSKQPTTRTTVFAGKGWISPHPLSRSPTEVASSPQSRIMLPSEAFPHGATMTFDEWKQMQEHGLRLHHNHSITESSRTYHGVYQDERYRHAAWEGRGSVDEGNLERDGSQSPVHSSLRFSAKTPHATDSSINADKHRGSSFSKANTRPSVKGSSLLAHGKEFTAPVLDARNDGGVSFVTGSAKFSRHQRSSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>N1QL59</accession>
    <name>N1QL59_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_145618</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764474.1">
        <property type="nucleotide sequence ID" value="XM_016903165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QL59"/>
    <dbReference type="GeneID" id="27900302"/>
    <dbReference type="HOGENOM" id="CLU_1595588_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF16353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="167" mass="18625" checksum="75C500D6ADCC09D3" modified="2013-06-26" version="1">MPPSPTTTNGLTRRDVEAEHLAAPCSPARTIRSQSASIHSTTPPLYSVEDPDQPPNYWEESNYSRPVFVTTAFTLKPPHYHGSRSGLRSHDSEESRYQAYWLGLEMGAASRYPPPALALRRRRRRRAGTSNVRHCVAIGAVITVVLVIAFAVKGKFETERHHANTGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1QL89</accession>
    <name>N1QL89_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uridine permease Fui1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_58898</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016766071.1">
        <property type="nucleotide sequence ID" value="XM_016909478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QL89"/>
    <dbReference type="GeneID" id="27906615"/>
    <dbReference type="eggNOG" id="KOG2466">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021555_2_0_1"/>
    <dbReference type="OMA" id="YEAFAGP"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11482">
        <property type="entry name" value="SLC-NCS1sbd_NRT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000001">
        <property type="entry name" value="Uracil permease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012681">
        <property type="entry name" value="NCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00800">
        <property type="entry name" value="ncs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF2">
        <property type="entry name" value="ALLANTOIN PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="452"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="480"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="524"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF17950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="569" mass="63002" checksum="2FD487DE6958034B" modified="2013-06-26" version="1">MEKFNRFAVPSEPGLTNAQLMLQNEDLKPVEAERRVWTSKNFVFFWISDSFNINTWMISSSNIVDGLSWWQSWLCVWIGYGITAGFVVLTGRIGAKYHLSFPVIARASFGIWGGLWPVLNRAAMACIWYGVQGWIGGTCVYLMIRSIWPSWDAYGPEGSKNSMPASSGTNTRDFVSFFLFWAGSLPFLWPAVHKIRHLFTVKAAVVPVAGMAFFIWAVVRADGLGPIVKQRGALQGSALAWAVIKGIMSAIANFATLIVNDPDFSRFARTPRDAFWSQLLTIPIGFALTSFVGIIVSSSSTVIFNLDEPIWSPLTLLTMFLEEPNVTGATRFGVFIIAASFALAQLGTNIAANSISAGTDLTALLPRWISIRRGSYLCAIVGLAMCPWHLLSSSNNFTTYLSAYSVFLSSIAGVMCADYYLVRKGYLQTKDLYSADRKGPYFFHGGVSWRGYAAYLAGILPNVVGFVGAVGVEVPKGATYLYNLNFFGGFIVAAAIYWILCKIKPIPACSDIWREVDNDVEYDEDDVDDDVSDVRDERRGRRRRNLAYGEEESDSDAKRQTTELPKGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1QLL2</accession>
    <name>N1QLL2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD-dependent monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_46179</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760312.1">
        <property type="nucleotide sequence ID" value="XM_016908986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QLL2"/>
    <dbReference type="STRING" id="692275.N1QLL2"/>
    <dbReference type="GeneID" id="27906123"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_3_2_1"/>
    <dbReference type="OMA" id="SLTIHWA"/>
    <dbReference type="OrthoDB" id="47494at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178:SF1">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178">
        <property type="entry name" value="MONOOXYGENASE, FAD-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="151"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF12191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="447" mass="49959" checksum="3EDDE249EA73581F" modified="2013-06-26" version="1">MGAPTAQQPQKEQKHIHILIIGAGLTGLILAQALRKLQHLASLNSNNTNTTTPPPPLITYEIFERDPRAFFRGGGWSLTIHWALTDLQNLLPDEIMQNFESCLVNRDAAAAGQAGNFQFLNLCTGERVEAWPIPRGAASRVSRERILELLMRGVDVRWSKHLTSLDFSHPSSVTATFADGSQAQGNLVIGCDGARSAVRRTLCATTWQNNRLPVRLLGLRVKFPLAKVAKCLAIDPHFFQGGDPLSNVYFWFSFIHLPRAVDVEGKGEEEEYATCQMMVSWPYSGEAADEMPETQTARRERIRQLATNWNETFRDLVYSIPETTELREIVLEDWPPVQGRWDNHNGRVTLVGDAAHCMTMFRGEAANHGVIDVSHLIKTCFPTTANTETMQPTRSCDLAQAVKSYEEEMITRTFPAVLKSRQACLDANNFASVNKESPLIAKRAMKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>N1QLM5</accession>
    <name>N1QLM5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Actin binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_145827</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764734.1">
        <property type="nucleotide sequence ID" value="XM_016903291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QLM5"/>
    <dbReference type="STRING" id="692275.N1QLM5"/>
    <dbReference type="GeneID" id="27900428"/>
    <dbReference type="eggNOG" id="KOG3655">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013085_2_0_1"/>
    <dbReference type="OMA" id="FKEPRGA"/>
    <dbReference type="OrthoDB" id="5971719at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11281">
        <property type="entry name" value="ADF_drebrin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11962">
        <property type="entry name" value="SH3_Abp1_fungi_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11961">
        <property type="entry name" value="SH3_Abp1_fungi_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000045">
        <property type="entry name" value="Actin binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035719">
        <property type="entry name" value="Abp1_fungi_SH3_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035718">
        <property type="entry name" value="Abp1_fungi_SH3_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829">
        <property type="entry name" value="CORTACTIN AND DREBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829:SF25">
        <property type="entry name" value="DREBRIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="ADF-H" evidence="5">
        <location>
            <begin position="5"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="650"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="739"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="156"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="244"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="285"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="709"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="426"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="461"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="529"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="555"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="630"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="748"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF16613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="797" mass="83669" checksum="D781D21437DF24FC" modified="2013-06-26" version="1">MAALNLSQNGPSITASYQKIVNSAPSGPAASSPTHGIWAIFSVKAPLANAFAADSGKESVLSVQTTGEGELADLIEDFSDGRIQFAFVKVKDPNTTLPKNVLIAWCGEGVPERTKGYFTSHLNAVSKVLHGYHVQVTARSERDLTPELIVQKVADSSGSKYSGGGSIPSAAAGPPPPKPSKPVLPTKSFGPTGGFSPLGRTRAAPPPSSTDADGWGEDAPPVTRSQLEKVASSYQPTKVNMAELQSKREPSQFQAPAPSNGNKADVVSGGYQPIGKVDIAAIRRQAQASGNTQDERPTVVKGAYEPVGKVDLNEIRRKAQAAPPPTRPTQSNEGDEDTPKSLADRSAAFQQNRPLTELPKPKVANNFGPQASNFAGTKAPTPIGFQSKPIQAAAPIGAASKSFADEGGKTPAQIWAERKARERGTSGVSDTQRTGEAPIQSQPSGGWQSSYGGKKWGVQIPTRTGGSGISEQRTGQPEDVQEEEQAPPTGGVGSIRDRFAGAAPMGAVQQHTGGAPEPPPLDNSSKPNAGVRGVAGVPPVQHQDLPPPPPRGVPQDEDEEDEDDNAAAAVDQGSPVRIAMPVGRGAEPIEPVEQLPSRGLPEASLSKVVSQHQDTEPPQVEAHDQARGSGEAAAATTFGEAEDPRGAGSAGGQEAIAQYDYEKDEENEIALKEGERITGIEMVDDDWWMGENSKGERGLFPSNYVELVEGGALQETHHTSQAVADEPPPPPAPPAQTSGGGQTATAEYDYEAAEENELSFPEGAKITNVEFPDENWWSGEYNGQAGLFPSNYVQLDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>N1QLP8</accession>
    <name>N1QLP8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Structural maintenance of chromosomes protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_34273</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764784.1">
        <property type="nucleotide sequence ID" value="XM_016908566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QLP8"/>
    <dbReference type="STRING" id="692275.N1QLP8"/>
    <dbReference type="GeneID" id="27905703"/>
    <dbReference type="eggNOG" id="KOG0979">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004969_2_0_1"/>
    <dbReference type="OMA" id="RFWTSQP"/>
    <dbReference type="OrthoDB" id="10254973at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001301">
        <property type="entry name" value="Structural maintenance of chromosomes 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecF/RecN/SMC N-terminal" evidence="12">
        <location>
            <begin position="46"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="212"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="370"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="663"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF16663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1106" mass="125603" checksum="242AB300BB0BE5AD" modified="2013-06-26" version="1">MRRLTRRQSEQSPLLPDGFRRSPKGKQRARLTANDHVQQEHQPGAIVRITMRNFVTYTNATFHPGPNLNMIIGPNGTGKSTLVCGICLGLGWKPEHLGRAKDVSEFVKHGCKEAIIEIELKADPQRQQTNPIIGCRISRDGGGKNNQDKKTAFKINGKTVSNKAVQEFCRSFSIQVDNLCQFLPQDRVADFAALSPVDLLVQTQRAAGGEQMSQYHEDLKKWRREEKALLNDQQNLFEELKRLEDRQRAQEMDVERMRERELVQEKLELLKRFRPCTEFNELKRKHEEARAREREAKEEKRRVEDQIEPNMRAVAAKETYVAAVKRAVESKKRMVQRSVETVAHVASRFKELEEAVAGCDAETKAETVNAAKAKQDVAKLQQAIRTIENAMASPPAEFNAVEMNEKTTQLGREIRTLEDELNRGHETVGELREQARQRQQIIAQEEEKQTHLQSQAGRLESKLSGVSRASADVWRWVQANKDKFEHEVFGPPMIVCAVKGGRDADWIEAMVGAGELKAFTVCSRNDFNVLTHQAYQVMGLTDVNIRNSTLGLDQYPTPDTSPEEMKRLGLDGWLMELITGPEPVLAMLCDNTNLHRNAFCKRDITEDQYDMLKKTSISSWCTPTNTYRMIRRGEYGDAGTAARVSPLHRARLLTDAPVSTQAEEDSKARIATLEGEISHIKEEMHGVRARAAQLKEKITKLKDEVESIKKEKAHLQQQKSQYDGLPTKLASNKARLADLQAQLAEQDARKWEIAQRQMRLIFEQGQQALDHGTAVRNLRDFQEELLRAEINGIEAASDLAQVTARNQADKDLLTTKENDLRVAIQKEREARRLGKAKSEAVHQLVAEMRNGDLTPLEDEIHELIKDWEPPALDTEIASVEASLELLAGTGNANLVREFEARAKKIEERRAQRKTLGDDLEALTTKIAQIRELWEPQLDELVRKISDAFSENFTFISCAGEVGIDKQEDFADWAIQIKVKFRENEQLQVLNSHRQSGGERAVSTIFYLMAMQSMARAPFRVVDEINQGMDPRNERMVHSRMVDIACAEHTSQYFLITPKLLNNLKYHPNMKVHCIASGEYMPDKSDQLDTFENMAQLALNLKRGVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1QMA4</accession>
    <name>N1QMA4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Gag1-like clamp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_112543</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764620.1">
        <property type="nucleotide sequence ID" value="XM_016900985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QMA4"/>
    <dbReference type="STRING" id="692275.N1QMA4"/>
    <dbReference type="GeneID" id="27898122"/>
    <dbReference type="eggNOG" id="ENOG502SRCS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036307_1_0_1"/>
    <dbReference type="OMA" id="WKSDGQW"/>
    <dbReference type="OrthoDB" id="5422958at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053274">
        <property type="entry name" value="Fluconazole_resistance"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025124">
        <property type="entry name" value="Gag1-like_clamp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28065:SF1">
        <property type="entry name" value="DUF4050 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28065">
        <property type="entry name" value="FREQUENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13259">
        <property type="entry name" value="clamp_Gag1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gag1-like clamp" evidence="2">
        <location>
            <begin position="132"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="217"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF16499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="390" mass="41952" checksum="0EFBCBE204163CE4" modified="2013-06-26" version="1">MTLHLNLPGSHHRSAEQQAQLREARRLLRDKIRNDWEYPPLPAWKSSGRHEAANSAATEELNVEDRIAGFRFHAPSTPDRANGVVGEALGLGFEPIEWREREDSDVSETESEVAAMTPAHTTSSSSKSKVETYKFDAPDSVGPQLHSRQQARKRKRWQAVHEEMEWNDGLAHWTRRRDVWCCARETRDVRLLEGSSGSGLADHAPPARGIVHIEVDSGSASGGSTPRTSTSSSVEAHVSSTPASTPSGSPDVTGAAAGSTAGTSLRSSPATIPLDVLVPIAPALLPKHPIRKRINHDMYPEIYNKIILQSRTPSVPINLLTLLRALVQGWKDDGEWPPKPGVLEKSFTTRRKRGGSGGGGGEGSLKSGVKAVGRVLRLTSSGGGGGGVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1QMA9</accession>
    <name>N1QMA9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_55912</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764630.1">
        <property type="nucleotide sequence ID" value="XM_016909380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QMA9"/>
    <dbReference type="STRING" id="692275.N1QMA9"/>
    <dbReference type="GeneID" id="27906517"/>
    <dbReference type="eggNOG" id="KOG2741">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_0_0_1"/>
    <dbReference type="OMA" id="FLERYMQ"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000017">
        <property type="entry name" value="Oxidoreductase family NAD-binding Rossmann fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF3">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G10240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="6"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="4">
        <location>
            <begin position="136"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF16509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="356" mass="39669" checksum="978940F6E596C8CD" modified="2013-06-26" version="1">MVRKLQVGVSGLGRMGARHALHFLDRTPRAELVAAFDPDEKALAWARQRLKPYGTKLYSDYEAFLQHPGLEAVVVAGITTQHAAQTIRAIEADKHVLCEKPLSTSVKICEDVERIARAKPHLKVLCGFSRRFDGSYRDAAHRIKRGDIGRPAILRSQTCDKHRDDDYFVQYAKFSGGIFVDANIHDIDLALWYFGADSIIKSVTAVGINARLTDLSQHQDVDNGVGIVEFHNGKIAYFYASRMMAAGQIDTTEIIGTHGKIVVNGNPQKNLVEVHEANGIRREVPQTYYDRFEEAFVTESNEFTECVLDGKELPFGLSGAITAVKIGDALQKSLRTGRKLEFNELGEEIVEDKARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1QME9</accession>
    <name>N1QME9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_146198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765224.1">
        <property type="nucleotide sequence ID" value="XM_016903511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QME9"/>
    <dbReference type="GeneID" id="27900648"/>
    <dbReference type="eggNOG" id="ENOG502SM8K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044491_0_0_1"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF17103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="413" mass="45933" checksum="8B89DE5A7EDFB6C2" modified="2013-06-26" version="1">MAIHRGIQSALFYYLSCAPCADVRYRKRRKQEAALSRAERLALDAEESNVYRHPGEPSSTNPHWQSEIELGPTFVRKGKKKASTGDSQRQLKVERANSNASHNATLPDFDPRSCSSATADRRWRSRSDGRGDEPWCGSSSLLQRPATARTNGSTATMYHTNYNPAINEMHPPTVTKVNRREDVIWMMQPVPISNVMGGSERGIRGRSDSGGGSRLRLSSTGLSTQVSTRLLEPRSRTGTPSVSGVSRESSFRSVAGPSEQRREKSGEHDFASMPPHSTDGSNESARSTLRIPELAAMRHPPRRATSRPQLSTVLSDGDLPSQMQRSTPKENSMPTSLPGVNGIIDILDGQAVRSARAGREKPVGAVFRHKHDDSEVSIRPELFDSWYTPDFELGKYIFEHTKREVHKRWSMDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1QMY3</accession>
    <name>N1QMY3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">2-oxoisovalerate dehydrogenase subunit alpha</fullName>
            <ecNumber evidence="9">1.2.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_146456</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 3-methyl-2-oxobutanoate + H(+) = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13457"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10497"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83142"/>
            <dbReference type="EC" id="1.2.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the BCKDHA family.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.4" evidence="9"/>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765539.1">
        <property type="nucleotide sequence ID" value="XM_016903663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QMY3"/>
    <dbReference type="STRING" id="692275.N1QMY3"/>
    <dbReference type="GeneID" id="27900800"/>
    <dbReference type="eggNOG" id="KOG1182">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029393_1_2_1"/>
    <dbReference type="OMA" id="GMFRGVN"/>
    <dbReference type="OrthoDB" id="3845at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003863">
        <property type="term" value="F:branched-chain 2-oxo acid dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009083">
        <property type="term" value="P:branched-chain amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02000">
        <property type="entry name" value="TPP_E1_PDC_ADC_BCADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000015">
        <property type="entry name" value="2-oxoisovalerate dehydrogenase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050771">
        <property type="entry name" value="Alpha-ketoacid_DH_E1_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43380">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43380:SF1">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="11">
        <location>
            <begin position="103"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="16"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF17418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="467" mass="52617" checksum="91BFA4E70E5DE1CA" modified="2013-06-26" version="1">MKRIAERHLWREIAATTRASGRRPARSSWQQQRWSSVSQRPGSDRVHFPGAVNSRFTTALNFARATEDDAMPTFRILDQEGRVIDPSLEPQISDEEVIKLYTDMVSVSVMDLIMFDAQRQGRISFYMVSAGEEGIAVGSASSLHPDDPIFAQYRETGIFQHRGFTFDDFMAQLFATKDDPGLARNMPVHYGSTKYRIHTISSPLATQLPHASGAAYAVKLQNQLNPTDEPRVVACYFGEGAASEGDFHAALNIAATRACPVIFICRNNGYAISTPTLEQYRGDGIASRGVGYGIDTIRVDGNDILAVREVTARARQRALQDAGEGKCRPVLIEAMSYRVSHHSTSDDSFAYRARVEVEDWKRRDNPITRLRKWMEDGRGIWNEEKEQTLRKETRKNVLTAYRKAEKEKKPPLGSLLRDVYKEPTEELLEQAAALKSVMERYPDEYDVAEFVGGMDGLKIDTHNKKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1QN89</accession>
    <name>N1QN89_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Wbp11/ELF5/Saf1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_146571</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765709.1">
        <property type="nucleotide sequence ID" value="XM_016903739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QN89"/>
    <dbReference type="STRING" id="692275.N1QN89"/>
    <dbReference type="GeneID" id="27900876"/>
    <dbReference type="eggNOG" id="ENOG502S9RI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078580_0_0_1"/>
    <dbReference type="OMA" id="MPKERNF"/>
    <dbReference type="OrthoDB" id="5597581at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019007">
        <property type="entry name" value="Wbp11/ELF5/Saf1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09429">
        <property type="entry name" value="Wbp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Wbp11/ELF5/Saf1 N-terminal" evidence="2">
        <location>
            <begin position="4"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF17588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="315" mass="35954" checksum="93F753EF900FAFC4" modified="2013-06-26" version="1">MPKEKSANPVAAQRKADKRKEIAKSKKNVQEQRNEKLARRNPERLQKQIDELKELESRNQLRPKDKETLAQLERDIRGIKRAREALGDAAPKFPSHERRTERTDRGDRGDARQEQRDRRQHLGKRRRDVDGPHSDSGSDTDPEVRNIPMPRDTPPPMPRQKFHDPQIGPDGQRMPHALPTKPAVAPPPPQLVYSSAPQLRDLKKEATKFVPAAVRQKQKQVKGQGRLLEPEEIDKLEKAGYYAAQKAAEEAGEEAARMEIEVEEAEAPPGTTDVDMELQLKRFEEEMKGLDPRQEQEPSSTKRVVQLEEVDDDGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNC8</accession>
    <name>N1QNC8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ER transporter 6TM N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_130359</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765774.1">
        <property type="nucleotide sequence ID" value="XM_016902353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNC8"/>
    <dbReference type="STRING" id="692275.N1QNC8"/>
    <dbReference type="GeneID" id="27899490"/>
    <dbReference type="eggNOG" id="KOG4711">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001788_0_1_1"/>
    <dbReference type="OMA" id="YMENLMH"/>
    <dbReference type="OrthoDB" id="2274698at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018823">
        <property type="entry name" value="ArAE_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049453">
        <property type="entry name" value="Memb_transporter_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994">
        <property type="entry name" value="ARAE_2_N DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994:SF4">
        <property type="entry name" value="ER TRANSPORTER 6TM N-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10337">
        <property type="entry name" value="ArAE_2_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13515">
        <property type="entry name" value="FUSC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="635"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="686"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="714"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="736"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="domain" description="Putative ER transporter 6TM N-terminal" evidence="7">
        <location>
            <begin position="52"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Putative ER transporter 6TM N-terminal" evidence="7">
        <location>
            <begin position="157"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Integral membrane bound transporter" evidence="8">
        <location>
            <begin position="661"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF17653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1057" mass="118212" checksum="CB8163100DE8D29D" modified="2013-06-26" version="1">MATQQHARPNDGTTESSSSDEAGGVNQNAASGTAKPAPSAAAAATSKKPNIFQRLWQKLDLDLITVMTMFKASLPPTIAIAFYQSHAVAGVYETLGYLVAITSVLGMCIMPRGMFVQTMLLNVLAVCVGAAFCLLSLYCGIKARQNTTPAGSPPTGYNSSASAVLAVWLFFQTYMANVLRSALPQFQFPVIIYSIFLVVSLTYGTQFPTMSYATSFMTRLIEAFLTGFGIATGVSFLIFPLSSRKVIFKELSGYLNGLGGLLKLQTAYLASLEDWEPDTDALTQDPEKTNGHKKSNGQAGPQQLFVTAPGKKLKETLQKIYELHTKIPTDLNFAKREIAFGKLSPKDLGEIWKRMRFILPPIFGLSAVLDILQRRAEESGWENGGPGDLHQQKQRKHIDDLHQLMKSLHEPVAFMSASLNSAFQHVLLTLELVEPPKKKKHNDEESAGLEPVPGTPAFAEGFRKQLDRFDGYKKQTLEEWCHQHGINIPPGFFDSTFIRPEHLDTRIEQAREENQRQLFFGLYIHHLLWKTGQAALDLVLYADQRKQDGALNKNRLIVPGVNTFKKWLRAAFGRQDYHDEDLLTADLSSSQALDLGESFGKSKDPEHLPPRNRWERIGEGIRWIPQALRSDHSAFGFRVACATLSLGIVCYLEASQRFFLRHRLLWALIMIPISMTRTAGQSTWSFALRILGTFVAMVATYIIWYIVDGKTAGVIFFLWLWIFLAFYILLKQKTLLVAGIISIVTAILVIGYELQTRVVGIAVSESNGQPAYQTYLLAPYRLATVCAGLATAYFWTIFPYPVSESTELRKDVGAALYMLANLSSIVHELVRARVQKTDGDENIKNTRGFHLEKARNIVFTKTLTLLTNLHQNSAFNKFQIRVGGRFPHQEYTNLIESIQRVLQYTSLIAYASRTFSSSSSENDSAWSTDFRKLLTEVNATSHHMTSLLSLLSSSLTGGRALPPYLDLPQHYHGMVFVQRLQAIDGDILSVRHIAEPEYAAFAVIQICAQCIRDDVMKITRHVRNLVGVIDFSFHVQDRERDEAQDDSSMDDNTAEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNG8</accession>
    <name>N1QNG8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Borealin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_78324</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the borealin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765864.1">
        <property type="nucleotide sequence ID" value="XM_016910191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNG8"/>
    <dbReference type="STRING" id="692275.N1QNG8"/>
    <dbReference type="GeneID" id="27907328"/>
    <dbReference type="eggNOG" id="ENOG502S9QE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038589_1_0_1"/>
    <dbReference type="OMA" id="ITMQQKQ"/>
    <dbReference type="OrthoDB" id="2392550at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032133">
        <property type="term" value="C:chromosome passenger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018851">
        <property type="entry name" value="Borealin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018867">
        <property type="entry name" value="Cell_div_borealin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16040">
        <property type="entry name" value="AUSTRALIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16040:SF7">
        <property type="entry name" value="AUSTRALIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10444">
        <property type="entry name" value="Nbl1_Borealin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Borealin N-terminal" evidence="11">
        <location>
            <begin position="23"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="80"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="231"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="268"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF17743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="289" mass="31223" checksum="08866E67393CF139" modified="2013-06-26" version="1">MDTMMRTPQPSPTRRVPSITQAQKRALVDNLQLEITERALRLRTQYAAQAQGLRARLDLRVNRIPHALRKRNMQELMDEYHAKSKPAPPPPVPVVVAAKQQKPETAQSSLSRAKPASKRKSDEISLGDNKENALAQSSQDIPNPKKRTKTVVTANSKATRARNAGPAGVLSPKSHNSRTLPHSPIKPMDKMYPPRPQSSAQTDSVKPTRAPSRQTKRPGAAPEADGGRASEGSNTSAGTTIVTKPGTRKAANTKKTVPARPAATSRKPAAAKLEAAPPAAGTRTLRKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNN9</accession>
    <name>N1QNN9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CBF-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_160711</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765570.1">
        <property type="nucleotide sequence ID" value="XM_016907905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNN9"/>
    <dbReference type="STRING" id="692275.N1QNN9"/>
    <dbReference type="GeneID" id="27905042"/>
    <dbReference type="eggNOG" id="KOG2154">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015945_1_0_1"/>
    <dbReference type="OMA" id="YYNNIVT"/>
    <dbReference type="OrthoDB" id="10263185at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030692">
        <property type="term" value="C:Noc4p-Nop14p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027193">
        <property type="entry name" value="Noc4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12455">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12455:SF0">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCAAT-binding factor" evidence="3">
        <location>
            <begin position="317"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF17449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="548" mass="61772" checksum="C969A1D5894C97CB" modified="2013-06-26" version="1">MPGMVTTDPDDNRKRKRSLHGTSSTKARKAPKVTTTTDTREAQILLLEQQIVASPAHYANIEKLQGFLAGGEHSTLAAVALCRVFCRLIAGEQLEKDKNASDHAAQTVQWLRGCLRKYVASLCDWIGSPDATEENTALALLMRIVKEEAAGTSKTAEQSWRNEKATFQATVKALLSKKEAEGARLQFVETHVEEHDDVRFYTFVAVRNLLSESNGPDVLDNAIEMLSQIEGVPESEDQLEDWYGEAPTHKSPLLSLNAHRKAAREAWMSIFRAQLSTEQRKSLLNITTTQLLPWFTNHIELLADFLTDSFNQGGATSLLALNGIFSLMTVKNLDYPEFYGKLYSLLDEDVLHSKHRSRFFRLLETFMSSTHLPASMIASFIKRLSRLALQAPPGAIVWIIPWIYNQLKQHPPCTFMLHRTYHPGHAIYAAHPNYTEEGMDDPFIMSQSDPMLTRAIDSSLWELETLRNHFHPNVATLAKIVGEQFTKRDYQLEDFLDHSYSTLIEAEVGKEMKKAPIVEWEIPKHILCTDEGGLNSIGTLLQNAIQMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNX9</accession>
    <name>N1QNX9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">N-carbamoylsarcosine amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_138454</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765920.1">
        <property type="nucleotide sequence ID" value="XM_016902879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNX9"/>
    <dbReference type="STRING" id="692275.N1QNX9"/>
    <dbReference type="GeneID" id="27900016"/>
    <dbReference type="eggNOG" id="ENOG502QS7S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068979_7_1_1"/>
    <dbReference type="OMA" id="VCNAYWS"/>
    <dbReference type="OrthoDB" id="1739143at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540:SF1">
        <property type="entry name" value="ISOCHORISMATASE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
        <property type="entry name" value="PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="29"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF17799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="225" mass="24171" checksum="EE891BBA60A0B0DF" modified="2013-06-26" version="1">MPSPDEHAEAASYRASGFSNRLGWGQRPALILIDICQAYFTPGSPLDCSSNPSAAASPDHMRALLSAARSNPDIPIIHTQVSYSKKDMSQAGLFYRKAPVIDLWLQGNDQKGYSTLLPGLSPLANEHVIIKQHASAFFGTELCSLLQYLRVDTVVICGVSTSGCVRATTLDALQNNFRPMVVGDACGDRSVAIHEANLFDMDAKMADVVGVEEAVEHLGGILVPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M3ARX5</accession>
    <name>M3ARX5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sedlin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_166737</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756375.1">
        <property type="nucleotide sequence ID" value="XM_016908253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3ARX5"/>
    <dbReference type="STRING" id="692275.M3ARX5"/>
    <dbReference type="GeneID" id="27905390"/>
    <dbReference type="eggNOG" id="KOG3444">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083394_0_0_1"/>
    <dbReference type="OMA" id="QNPFYEP"/>
    <dbReference type="OrthoDB" id="18320at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006722">
        <property type="entry name" value="Sedlin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12403">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04628">
        <property type="entry name" value="Sedlin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF08254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="181" mass="20100" checksum="DDDA5440666CFBA8" modified="2013-05-01" version="1">MDRAPSIAAIAIMGRHNNPLHIALFPATGSTESQYAAERDQLEYHMMLNSCLDIFEARIPTKAIGHDFGLLHALDERIAMYGWLLNTGVKLVIVVDMEGRQARNAEEAKLGMLGLRGSDLTPAFQALQQAYVSLLRNPFYVPDEHDPKTAQEKGNMQINSPKFLKEVDRIGNVWSPGITAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M3ASI5</accession>
    <name>M3ASI5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_121235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756575.1">
        <property type="nucleotide sequence ID" value="XM_016901674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3ASI5"/>
    <dbReference type="GeneID" id="27898811"/>
    <dbReference type="HOGENOM" id="CLU_630323_0_0_1"/>
    <dbReference type="OrthoDB" id="3649545at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="75"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF08454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="435" mass="51008" checksum="375DC669A226F237" modified="2013-05-01" version="1">MRIVLFCLEKFWGHPIKSSYRASGIDAQQQSASATAYLNPTRQSILKMDQFPTPSVNGPVPYIADVKELCDSTTVTIFLVVRPEVRRFHVPKTLICAHSAYFRAMFTNPVFEEATSQKVIIREQIHMWAFITFVQWMFTQRLILTATPETSIEELLEDGDAADPRTWPYSTLFSLYAMADFLDSIGMRRLIIQQVQIKMRSIDECPRPSYEDLVLLQQLVPGSSPLRQWIAFDIVVRTSNDSKEPDDMVNQYSKLFEEAGNEESLAEFHRDINSIKEVIAEQSDCANCGQYVKPNGSDAYKRCSKRHHLSTARKREKWAATCMFHEHTHESEYKFCKVHFRCFLKGKVADWIKLWNWDAEPEEEWNEEETEEETEEETEEETEGEMLQDLLRDEWRDEWQDDQDSDASDDAMYEDLSWIRPVDMKRYDSWDDETW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M3AU36</accession>
    <name>M3AU36_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UPF0203-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_73372</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRIAP1/MDM35 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757115.1">
        <property type="nucleotide sequence ID" value="XM_016910023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AU36"/>
    <dbReference type="STRING" id="692275.M3AU36"/>
    <dbReference type="GeneID" id="27907160"/>
    <dbReference type="eggNOG" id="KOG3481">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101473_2_0_1"/>
    <dbReference type="OMA" id="KKYDDCF"/>
    <dbReference type="OrthoDB" id="19091at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990050">
        <property type="term" value="F:phosphatidic acid transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007918">
        <property type="entry name" value="MDM35_apoptosis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46403">
        <property type="entry name" value="TP53-REGULATED INHIBITOR OF APOPTOSIS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46403:SF1">
        <property type="entry name" value="TP53-REGULATED INHIBITOR OF APOPTOSIS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05254">
        <property type="entry name" value="UPF0203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF08994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="86" mass="9993" checksum="836BDF1750E01EC7" modified="2013-05-01" version="1">MSASLAPECNEVKERYDSCFLKWYSEKFIRGTAKTDECEPLFRQYKECLGKALKERGIDTMLEEARADNKENDLEYMKPTTSPKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M3AUS6</accession>
    <name>M3AUS6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_119562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF09821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757942.1">
        <property type="nucleotide sequence ID" value="XM_016901523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AUS6"/>
    <dbReference type="GeneID" id="27898660"/>
    <dbReference type="HOGENOM" id="CLU_1289659_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="214" mass="23933" checksum="3309F87DD2C39FAF" modified="2013-05-01" version="1">MATTTRSFPPSTTTQHNVDPWQAGRGQRRVYPPSRFSRFDETSSAARRIHQTSSVPKSTHRHDFSGSSPSVPVLRLKTAQEPRAPDAQPPTRTIHHQKSHPLRQLISSRSRPPSHPAVASQVRPQNLVHFASLSVQPAVRRRVSLRGRKPLLALLNEIADRSRLLGVRETLVGFETIWTDGIGIRKDMGAEGDIRGRNGRGRFGGDNGKMLRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M3AXH2</accession>
    <name>M3AXH2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_150376</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759561.1">
        <property type="nucleotide sequence ID" value="XM_016906128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AXH2"/>
    <dbReference type="STRING" id="692275.M3AXH2"/>
    <dbReference type="GeneID" id="27903265"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_1"/>
    <dbReference type="OMA" id="EPNNEPY"/>
    <dbReference type="OrthoDB" id="5840532at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF8">
        <property type="entry name" value="ESTRADIOL 17-BETA-DEHYDROGENASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF11440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="279" mass="30099" checksum="F93B12C28F7003EA" modified="2013-05-01" version="1">MASKNYLITGAGRGIGRGLSRLLLQKGHRVFLVDNNEAELKHIITNISKDHNSSTRYTSALCDLRQHQAIQQTVADAKTFFNGHLDVLINNAADTSSVGRSHLSELTLEDWNSAVETNLTAPMLLSQACLPLLKSSSSSSSSSRPEGERAGGGGVIINISSTRALMSEPNNEPYSATKAGLLGLTQSMAVSLAPQGIRVNAILPGWIHVANECKEADEKGQKWEEGLTREDHAWHLTGRVGRVEDVLKAVEYLVENDGVSGAELVVDGGVTRKMVYPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M3B0Z2</accession>
    <name>M3B0Z2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbon-nitrogen hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_42484</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761538.1">
        <property type="nucleotide sequence ID" value="XM_016908871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B0Z2"/>
    <dbReference type="STRING" id="692275.M3B0Z2"/>
    <dbReference type="GeneID" id="27906008"/>
    <dbReference type="eggNOG" id="KOG0805">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030130_6_1_1"/>
    <dbReference type="OMA" id="HIAVWPG"/>
    <dbReference type="OrthoDB" id="2017782at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000016">
        <property type="entry name" value="Nitrilase blr3397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044149">
        <property type="entry name" value="Nitrilases_CHs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044:SF12">
        <property type="entry name" value="HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044">
        <property type="entry name" value="NITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="5"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF13417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="335" mass="36743" checksum="AFB18BE78E11A048" modified="2013-05-01" version="1">MPQKLTLAVSQSRTLSTLSSTLSSLASTTRLAASQNVDLILFPEAFLGGYPRTAAFGATVGSRSEAGREQFLQYFHSCVDLGDTPTGAGEDWIQKKNLPIAEGKECRGDGTREFLEQVARETGVFVVTGVVEKSGGTLYCAVVYVCPRRGVIGKRRKVMPTGSERLVWGQGSPATLKAITTTIRNVRVVMAAAICWENMMPLLRYSLYSQNVNLWLAPTADARDTWLPLMRTVGNEGRCFVLSSISCQKRKNLPEWKEDDDDEFVCRGGSCIIGPFGQVLQEPLWDVEDGGLLVQEVDFEDCERGRLDLDVAGSYSRNDAFKLTVEGLDLNPPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M3B1B4</accession>
    <name>M3B1B4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_148822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761693.1">
        <property type="nucleotide sequence ID" value="XM_016905170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B1B4"/>
    <dbReference type="GeneID" id="27902307"/>
    <dbReference type="eggNOG" id="ENOG502R935">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_794937_0_0_1"/>
    <dbReference type="OrthoDB" id="3625729at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF13572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="349" mass="39750" checksum="8D073393F34047E7" modified="2013-05-01" version="1">MAAIVSFLPDSFPFRPFFPLSFLSRGRPPGNNDSNEYIVPDSLATIPTASLHVCTSAPSSGRRSWFFYLTSSSETVITMPRYEEAPPSYSDAVILDKLRAEVQRHDEELYGDQIERSSSTEEDESESVWESQYGECPPVAKWLVQTTAEPSMWKLMSGPLMSNATTAYNNDPLHKRRYAVLFPPGYEDVYLHKSTWYANAATLPPYHVEIYSCKNNGRYEAEPIIVLGPTEGDDDVMEAFARSHAALHVSKVFARVEQAMSQTSRLVTFCEGEFFSWDWKRKTSAARHDMQVLINKARKELIRDASFVVRLDQYLDFVGKAGDTQLLSNMEFFRGSIKDSGRRLRRMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M3B1E2</accession>
    <name>M3B1E2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_141012</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761733.1">
        <property type="nucleotide sequence ID" value="XM_016902950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B1E2"/>
    <dbReference type="GeneID" id="27900087"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_11_5_1"/>
    <dbReference type="OMA" id="PAFNMKY"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000149">
        <property type="entry name" value="MFS transporter, SP family, general alpha glucoside:H+ symporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF5">
        <property type="entry name" value="ALPHA-GLUCOSIDES PERMEASE MPH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="387"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="433"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="462"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="39"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF13612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="537" mass="59631" checksum="6F392E1DFBF5603D" modified="2013-05-01" version="1">MQSGATPKNVAHNASRATDAEHSMSFWQSIKKYPKAVGWSVLLSTALVMEGYDVTLLGNLFSQPAFQKRFGVSDGKGGYQVTAPWQSGLSNTFNVGSIMGLLIAGTCAERFGYRRTMMGALTMIIGAIFVVFFANGLLMLLFGEILCSMCWGIFQTITVTYASEVCPLTLRAYLTTYVNLCWVIGQFIGAGVLRAVVDRTDQWAYRIPFAIQWIWPIPLITGIFFAPESPWWLVRKGRNAEAEKALRRLTSVDPLDESSTNDTLSLIIYTTELEKSQQEGTSYWDCFRGIDLRRTEIVCCVYAIQVTCGCPIMGYSVYFMEQAGFSPRNAFSMSIGQSGIGAIGTISSWFLMAHVGRRTLYLAGAVLMALVLLIIGFIGLAPKSNTGAQWGIGTLLLVLTFVYDITIGPVCYSLTPELSSTRLRNKSVVLARVAYNIAGILANVLQPYMLNPTSWNWGAKSAFFWVATCAISVAWIFWRLPEPKDRTYAELDVLFRNRTPARKFKTTTVDAFIYAEEIEGKLAKHEKDTTAVHIEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M3B2S0</accession>
    <name>M3B2S0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">tRNA(His) guanylyltransferase</fullName>
            <ecNumber evidence="3 14">2.7.7.79</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 14">tRNA-histidine guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">SEPMUDRAFT_41491</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 14">Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a 5'-end ribonucleotide-tRNA(His) + GTP + ATP + H2O = a 5'-end phospho-guanosine-ribonucleotide-tRNA(His) + AMP + 2 diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54564"/>
            <dbReference type="Rhea" id="RHEA-COMP:14193"/>
            <dbReference type="Rhea" id="RHEA-COMP:14917"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:141847"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.7.79"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="16">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the tRNA(His) guanylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.79" evidence="3 14"/>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762198.1">
        <property type="nucleotide sequence ID" value="XM_016908830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B2S0"/>
    <dbReference type="STRING" id="692275.M3B2S0"/>
    <dbReference type="GeneID" id="27905967"/>
    <dbReference type="eggNOG" id="KOG2721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044271_1_0_1"/>
    <dbReference type="OMA" id="WKQHTEI"/>
    <dbReference type="OrthoDB" id="62560at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008193">
        <property type="term" value="F:tRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3000:FF:000001">
        <property type="entry name" value="tRNA(His) guanylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025845">
        <property type="entry name" value="Thg1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024956">
        <property type="entry name" value="tRNAHis_GuaTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007537">
        <property type="entry name" value="tRNAHis_GuaTrfase_Thg1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038469">
        <property type="entry name" value="tRNAHis_GuaTrfase_Thg1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12729">
        <property type="entry name" value="TRNA(HIS) GUANYLYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12729:SF6">
        <property type="entry name" value="TRNA(HIS) GUANYLYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04446">
        <property type="entry name" value="Thg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14413">
        <property type="entry name" value="Thg1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028980">
        <property type="entry name" value="tRNAHis_guanylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10 14 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 14 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 14 20" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNAHis guanylyltransferase catalytic" evidence="18">
        <location>
            <begin position="7"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Thg1 C-terminal" evidence="19">
        <location>
            <begin position="145"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="231"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="75"/>
            <end position="76"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR028980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR028980-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR028980-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF14413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EMF14077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="282" mass="32208" checksum="0473DDF2B506E598" modified="2013-05-01" version="1">MANTEFSYVKTFESNDVLPPSQWIVIRIDGRGFSKLCIKYNFQKPNDARLMHLMNSAAERVLQAFPDMVLAYGQSDEFSFVLHEDTRLFERRSAKLSSSVATMFTAEFCMGWVDAMGVEVGGDGKLERPWPTFDGRCICYPKKKIIRDYLAWRQADCHINNLYNTTFWNLVLKGGMSGTEAEQELKGSVASDKNEILWSRFGVNYNQELEVWRKGTVMYRVYDDVGGGGGGEEKGVDAKSKSQLEKERKRKMKAKIVQEHTDIIGDGFWEKRPYILATRGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M3B317</accession>
    <name>M3B317_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_147996</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762318.1">
        <property type="nucleotide sequence ID" value="XM_016904636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B317"/>
    <dbReference type="STRING" id="692275.M3B317"/>
    <dbReference type="GeneID" id="27901773"/>
    <dbReference type="eggNOG" id="KOG4336">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="63"/>
            <end position="130"/>
        </location>
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            <begin position="184"/>
            <end position="232"/>
        </location>
    </feature>
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        </location>
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        </location>
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        </location>
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            <begin position="18"/>
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        </location>
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            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008767"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF07524"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF10406"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMF14197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="331" mass="36665" checksum="A4720C5564733139" modified="2013-05-01" version="1">MAMPESTSPAGTKRPHPSTTATATASASPEHSTKRRRIIHHALKHVQHIPQDIEPAPQDPVFAQGQLLKSISAALVMVGYDAVLPTALEMFRSHVEEYMLKFLSHTRTSMHNNRRTIPTALDFSQSLANMPSSHLPQLLLPQLALDVPEDISYPSIPEPDPAPPKMDDFSKLLEPLIEQHPPAWMPRHFPPLPPKHSWKETAVFPQRETDSRKLREKATEEGVLAEQALRRLAAAAKSSAVHAEKNRHNALRGEGKVRNPSRPGGRAAARKHEDTFAEMLREEGGGDEAAELASDAADTRTGVDLSMPEGVVVNHHNAYWRRPGQRRGTRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M3B504</accession>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">SEPMUDRAFT_59061</name>
    </gene>
    <organism evidence="3 4">
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            <taxon>Dothideomycetidae</taxon>
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            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
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        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
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            <begin position="90"/>
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        </location>
    </feature>
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            <begin position="123"/>
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        </location>
    </feature>
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            <begin position="155"/>
            <end position="175"/>
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    </feature>
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        </location>
    </feature>
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        </location>
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            <end position="346"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF14862.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="380" mass="42055" checksum="0EDC8FBD938A56A1" modified="2013-05-01" version="1">MYGGRGIQEDISTSPNTKPSPFGAIKRIRAPGRPRAQSYRTLDGLLAGRDAVAWYWRSVGIASSFLILGGFLMLPVTFERDPVLRVAEAALGIFALALLTAGFSFTALLCYAVRNPLFRADNVFLPAFTSCALGLLTVFYNFLVFKRYYWNTPALLVTIGAAVSTTVYGGLLIWAQQRVGKERTRIQCLPVPMMQMGTTTRNNAGAETSYRPFAQEQTYYSNYNQNMFPSAYSRAGEGLPQQPPPPLQTGGGYDPNCITEEEMQRQQMLMLLLNREEQPASPHPTTTSSTYQIDWQEEDAITATTPAGGWFAPPPPMTATHTPSSSYSQTAKPFSASAQSNASPITAQDLRPWDGVWREVRRPASQDLREARRREIEGLP</sequence>
</entry>
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    <accession>M3BRH8</accession>
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        <recommendedName>
            <fullName evidence="3">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="1" type="ORF">SEPMUDRAFT_53326</name>
    </gene>
    <organism evidence="1 2">
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        <name type="synonym">Septoria musiva</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="OMA" id="HAGMRGS"/>
    <dbReference type="OrthoDB" id="3637259at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF08728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="17788" checksum="9D456DA9DC65C9F1" modified="2013-05-01" version="1">MAERSSTFIELHEDDPDRIAERLCNRFRLSVLTLNNRDYDHKTASGQEVQSYVSPDFRAHFDNIPKPMNWNESTEMWRAWQARDPDVYFEVMHCSCNVNLAKGEAIVIAEVKVTGSGDVTLGGLSEASWKRHQDGRWYTDFYIGIRGNPQNGGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>M3BSI9</accession>
    <name>M3BSI9_SPHMS</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_93496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016910619.1"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_2559762_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="82" mass="9191" checksum="6E37869F1BC8A909" modified="2013-05-01" version="1">MGLQSLREHVREESLTGHRPCQSMEGRGGQSIVAKKRYAKKLVYWTQITIARRACISCARDLGEGSQRRQPDHPTNEGGNTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M3BW48</accession>
    <name>M3BW48_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PWWP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_118822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759665.1">
        <property type="nucleotide sequence ID" value="XM_016901458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BW48"/>
    <dbReference type="GeneID" id="27898595"/>
    <dbReference type="eggNOG" id="ENOG502R964">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_647273_0_0_1"/>
    <dbReference type="OMA" id="DYASECE"/>
    <dbReference type="OrthoDB" id="3825471at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF11544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="486" mass="54757" checksum="E4CA2EB439420B6C" modified="2013-05-01" version="1">MDKAIGSTWVAIIEGKRWPVVLCGEDVTPKKFVALRTDPQHLPAIQLGRRRYLFVHDKMLEEYDHNKTNYTSSLWASHGNEDPRGDGEDLREERQIAFGTDACKFQDDKYWVNFLVEQSKLRKLGRGQQRSSSNSLKRRASVTTEHLAVEEEGHRSQSSIPESKRRRVHAHGSSHRPSTPARTSREHQRRQHSVTGAIQLSGNEVEGETVLENEIVAATNFPGNPHRVTQSVETSTRLAKNSRSTLSLPPARLGPDQCELILPHGEDKYLVINKDIIPKCSYLSTRNPSSSSSSKIDLTHDQRANDVQLVATDFSAVLQFYQTGDIGPRFIINNNNNNNNNKPLQFSPLDLSPDQKAAHVESLAKAYVTAVKIQDENLQHLILQKLQLLGSSSFSSSFSSLSILILASCFSHLAALKTTAHIEKDATENDNDDEISLWVLDLVKNHYWLLVRNHIDELQTLFEHNHSMRRAVYDFLRGNPLGGREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M3C163</accession>
    <name>M3C163_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PRELI/MSF1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_147884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SO2202</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2012-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genome evolution in poplar pathogens from wild and recently domesticated pathosystems.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Dhillon B."/>
                <person name="Feau N."/>
                <person name="Sakalidis M.L."/>
                <person name="Gill N."/>
                <person name="Aerts A."/>
                <person name="Ohm R."/>
                <person name="LaButti K."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Copeland A."/>
                <person name="Beauseigle S."/>
                <person name="Grigoriev I.V."/>
                <person name="Goodwin S.B."/>
                <person name="Tanguay P."/>
                <person name="Hamelin R.C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762157.1">
        <property type="nucleotide sequence ID" value="XM_016904574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C163"/>
    <dbReference type="STRING" id="692275.M3C163"/>
    <dbReference type="GeneID" id="27901711"/>
    <dbReference type="eggNOG" id="KOG3337">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067902_0_0_1"/>
    <dbReference type="OMA" id="MKFFENN"/>
    <dbReference type="OrthoDB" id="341300at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006797">
        <property type="entry name" value="PRELI/MSF1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037365">
        <property type="entry name" value="Slowmo/Ups"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11158">
        <property type="entry name" value="MSF1/PX19 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04707">
        <property type="entry name" value="PRELI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50904">
        <property type="entry name" value="PRELI_MSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRELI/MSF1" evidence="1">
        <location>
            <begin position="2"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF14036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="242" mass="27295" checksum="BCEDB9BCAA292EC0" modified="2013-05-01" version="1">MVKFYQSNYSYDYGFSAVSLAYFLRYPNPYSRHVASTDTIERHYDPETQRLTTVRLHLKKSRLPAGVLALLPRSALGASEDGSTQSFILEKSVVDVKEGWMATDSRNLDWNNVLSVIEKHTYRRPEALAATDVNEVRTDVDVSVTLKSRIGEQIRKRRERWGQQANATSVVGASDEEPAKQGFFSNWTSGAVRTAIESIGMQRTEKSQPKAQKGMYVVLARLREGGVQAVMEGMRKDRELAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M3C7U7</accession>
    <name>M3C7U7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SEPMUDRAFT_31767</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF07960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756081.1">
        <property type="nucleotide sequence ID" value="XM_016908475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C7U7"/>
    <dbReference type="GeneID" id="27905612"/>
    <dbReference type="eggNOG" id="ENOG502SKG6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_6_4_1"/>
    <dbReference type="OMA" id="DWTILAC"/>
    <dbReference type="OrthoDB" id="3626004at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF160">
        <property type="entry name" value="SAT4 FAMILY MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="183"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="15">
        <location>
            <begin position="2"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="16">
        <location>
            <begin position="83"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF05730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMF07960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="335" mass="37948" checksum="801F62CB6AC16CD5" modified="2013-05-01" version="1" fragment="single">LCFVQEFPDYDCPLNNPSCMCSNANLTTAISACTFANCTTPEQLFVERISKRLCGATVRNRAPVIRRITWSLFGLACLFVGARFVARPERLHGSGYGKDDWTILACMALLVPVNSFVELMTNNGLGTDNFTLSPRQITLFLKYFFVFTILYTVLVMLTKVSILQLYLRIWSEDAVSIWFRRTCWFLVAVHLVTILAFVFSEIFICSPVPYSWHFWDGLHQGSCANRAAQLYALGAINICYDVVVFILPLHNFLKLNISWRRKTGVLTIFMVGMLVTICSIIRLQYLVKIGHSSNPTWEYSNAVIWSSVECNFSVICTCMPAMAGLLQRIWAKLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M3C803</accession>
    <name>M3C803_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_152327</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF08020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756141.1">
        <property type="nucleotide sequence ID" value="XM_016907378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C803"/>
    <dbReference type="STRING" id="692275.M3C803"/>
    <dbReference type="GeneID" id="27904515"/>
    <dbReference type="eggNOG" id="KOG2551">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051938_2_0_1"/>
    <dbReference type="OMA" id="CYSGFIA"/>
    <dbReference type="OrthoDB" id="2094269at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF6">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="3">
        <location>
            <begin position="4"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="225"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF08020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="237" mass="25498" checksum="3FC68BF73EB7042C" modified="2013-05-01" version="1">MKLSPEDVPSLIANSTEDGNGGLRDEAYGWWTRENDSEPYQYRGLDNGLAAIAAVLREEGPFDGVVGFSQGGCAAGMVTALLEDGRKEAFNRHYAAQGGYCFPESFLGEEKGSTVHPAFKFAVSYSGFGASRMQQYRAFYEPKIVTPMMHFIGSVDTVVSEERSLQLVNDCVGGEEAGNGGRVVRHPGGHFLPTSKTSVVPLVAFIREVMNGQAGSGNSHGGAEKEEESVEDMDVPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M3C8B4</accession>
    <name>M3C8B4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_152409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF08135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756256.1">
        <property type="nucleotide sequence ID" value="XM_016907429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C8B4"/>
    <dbReference type="GeneID" id="27904566"/>
    <dbReference type="HOGENOM" id="CLU_1696594_0_0_1"/>
    <dbReference type="OMA" id="INSWAEY"/>
    <dbReference type="OrthoDB" id="3632853at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF08135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="17337" checksum="914AF1965DED84E4" modified="2013-05-01" version="1">MTSSLDILRPSPSPPDATSSSRSATKDLETRSLKFAEIMGTRNYADPVFQQLVTPDFKCQIELPDGSIGMVQSREAFVSHFRKNTRTRLLDVSNVTIDLDEDAGLAKVMLLLRLGDTPRPVPQEAVSILWWKLDRGSWRCYQQTGMRGSLSIHGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M3C8F9</accession>
    <name>M3C8F9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pre-mRNA-splicing factor 38B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_136961</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF08175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756296.1">
        <property type="nucleotide sequence ID" value="XM_016902817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C8F9"/>
    <dbReference type="STRING" id="692275.M3C8F9"/>
    <dbReference type="GeneID" id="27899954"/>
    <dbReference type="eggNOG" id="ENOG502S07H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_877627_0_0_1"/>
    <dbReference type="OMA" id="ETDNHNT"/>
    <dbReference type="OrthoDB" id="2431475at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40132">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40132:SF1">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF08175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="37154" checksum="DE7362189BE6B2BE" modified="2013-05-01" version="1">MAAFSDDYVASILQREADKKSTSNLSSLFSSVGSVTRATKPRSAAPKPNARFLRNLVRDVDSHNAALKEKEERESRRRMWDLQRGKKGERPERVKRKVEVEAEDDDGKEAGSKRRRRSLERYAPGSARHGRAKDSSPTATERKHHHHRSENRRQERDKERSRSRSPDRERKHHHHHHHHHHHHRSKRSREHERDKAKARSRSRSPDRSHHSSIRRRREVQKEEEEEEEEQSSSEAEIGPELPARGRGSQHASILDRPEEAERGKTTRPEVVVEEDIANVKWTAIGQKREWDRGKEQDPFNIKSDSEEPEEMWAGRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M3C9N9</accession>
    <name>M3C9N9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Hydrolase, TatD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_53904</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756671.1">
        <property type="nucleotide sequence ID" value="XM_016909280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C9N9"/>
    <dbReference type="STRING" id="692275.M3C9N9"/>
    <dbReference type="GeneID" id="27906417"/>
    <dbReference type="eggNOG" id="KOG3020">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031506_1_0_1"/>
    <dbReference type="OMA" id="YGGSQKH"/>
    <dbReference type="OrthoDB" id="6079689at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006309">
        <property type="term" value="P:apoptotic DNA fragmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050891">
        <property type="entry name" value="TatD-type_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060:SF15">
        <property type="entry name" value="DEOXYRIBONUCLEASE TATDN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060">
        <property type="entry name" value="TATD FAMILY DEOXYRIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR005902-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF08550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="332" mass="36231" checksum="DE7AE65F8E5D1299" modified="2013-05-01" version="1">MATIVTPNASVATDGEPQREPALRYADIGINLSDPIFRGISHGKKAHEDDLEHVIHRAQKAGVQKMMVTGSDLKESQNAIKLAEVYPGLCFATIGVHPCSAESFETYPAGAEQLLADLKDLAVRSRDAGTATAFGEIGLDYDRLQHATKETQLKYFALQLDLAVELEMPLFLHSRAAAADFEALLKERLDKLPKRGVVHSFTGSLEEMQSLVKLGFDIGINGCSMKTEENCAVVKEVPLERLQIETDGPWCEMRPSHASAAYLKLDGAPELPKSVKKEKWAAEFMVKGRNEPCAMPRVAWAVAGIKGISVEEVAEAAWRNSIRMFGLGATSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M3C9V8</accession>
    <name>M3C9V8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AFG1_ATPase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_74466</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AFG1 ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756761.1">
        <property type="nucleotide sequence ID" value="XM_016910066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C9V8"/>
    <dbReference type="GeneID" id="27907203"/>
    <dbReference type="eggNOG" id="KOG2383">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008681_7_0_1"/>
    <dbReference type="OMA" id="WMAKKLV"/>
    <dbReference type="OrthoDB" id="548867at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005654">
        <property type="entry name" value="ATPase_AFG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169:SF2">
        <property type="entry name" value="AFG1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169">
        <property type="entry name" value="ATPASE N2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03969">
        <property type="entry name" value="AFG1_ATPase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="622"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="626"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF08640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="682" mass="76721" checksum="E389E44C6E1B1A9B" modified="2013-05-01" version="1">MSASVATGLAITNPLVKYRALLATRAIAPDPAQHRLAIHLAKLYDRLKDYEPELEYSHQLDQIARAVHAQQHVKNAHPYPPPRRSLWRELFAAKERRDSLALTRKLTSYESALQMDSPKGLMLHGEVGTGKSMLIDLFADCLPNRKKRRSHFNTFMLETFAKLETLRSDRMRSGRSNVPSSLSLADDDYSLVWLAKEMIQTSPILFLDEFQMPDRVASKILTNLMTSFFQLGGVLVATSNRMPEELAKAAGISYSPPADQRGFGWQLGLGRRRRPPAGRYSGHNEFTAFLEVLKARCEVWEVEGSRDFRRMDSGSVAPLKGIDLDDLDSLDSGYVSAESTVAPEKDLPIQPPKHFDIATQGATADTDAAISSALGGQSIAAWSPATMMVYGRNIHIPRAFEGVTMWTFDELCKGTYGPADYISLASTYHTLVLTEVPVLNWLMKNEARRFITLLDALYECRCKLFVSAAAGPDDIFFPEEKKRAEEGDNGDAVYSETLSEVYQDATAPFRPNVLTQNPNYSEPENEPDYTHARLAGLLSADARTRPNFQKTAAFTGEDERFAYKRAQSRLWEMCSERWWQRNEAGWHRPTPREVRRWEGREDGRKVGEDIFTGINSEIQMGEAVEDTTRPPESFKRYDGGPFKKPLEPAKKISWTHAWGLGEWGKRAGAWGKGVDGLKSKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M3CAP7</accession>
    <name>M3CAP7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">HAUS augmin-like complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_52504</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SO2202</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2012-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genome evolution in poplar pathogens from wild and recently domesticated pathosystems.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Dhillon B."/>
                <person name="Feau N."/>
                <person name="Sakalidis M.L."/>
                <person name="Gill N."/>
                <person name="Aerts A."/>
                <person name="Ohm R."/>
                <person name="LaButti K."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Copeland A."/>
                <person name="Beauseigle S."/>
                <person name="Grigoriev I.V."/>
                <person name="Goodwin S.B."/>
                <person name="Tanguay P."/>
                <person name="Hamelin R.C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HAUS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757021.1">
        <property type="nucleotide sequence ID" value="XM_016909230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CAP7"/>
    <dbReference type="GeneID" id="27906367"/>
    <dbReference type="eggNOG" id="ENOG502S1U0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068908_0_0_1"/>
    <dbReference type="OMA" id="QAKDWAY"/>
    <dbReference type="OrthoDB" id="5372507at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070652">
        <property type="term" value="C:HAUS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026243">
        <property type="entry name" value="HAUS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31570">
        <property type="entry name" value="HAUS AUGMIN-LIKE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31570:SF1">
        <property type="entry name" value="HAUS AUGMIN-LIKE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25762">
        <property type="entry name" value="HAUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="217"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF08900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="32227" checksum="34FB8AB9A940DE82" modified="2013-05-01" version="1">MDAEWTASALFSPSKARVQQAQAKDWAAVEAWISKKYGSRIPPFERNEDTLQALLALANLNENADEQRSQVERIEKAALASLTRKQGGLHEEALQMLQAELSHEAHLDTLAETVVALDCPSTNTQDVARHIILLNTTEFQLRQQLSQAEQQLANLKLESQRMHNLAKDLANPDFEAPTDVVDNTTEWVKTTKTLKAKVAEYDERLSASRPSSSSNALEHVDRKKLELEKQQQRLRDLEMELKAFQELPTDARLARAKLEEARRHLRQLTTRRNELFENLADSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M3CCK4</accession>
    <name>M3CCK4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Enolase</fullName>
            <ecNumber evidence="3">4.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">2-phospho-D-glycerate hydro-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">2-phosphoglycerate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SEPMUDRAFT_151160</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(2R)-2-phosphoglycerate = phosphoenolpyruvate + H2O</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Mg(2+) is required for catalysis and for stabilizing the dimer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the enolase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="3"/>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758253.1">
        <property type="nucleotide sequence ID" value="XM_016906639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CCK4"/>
    <dbReference type="STRING" id="692275.M3CCK4"/>
    <dbReference type="GeneID" id="27903776"/>
    <dbReference type="eggNOG" id="KOG2670">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031223_0_0_1"/>
    <dbReference type="OMA" id="RCMMSHR"/>
    <dbReference type="OrthoDB" id="1739814at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.10:FF:000001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.120:FF:000002">
        <property type="entry name" value="Enolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01060">
        <property type="entry name" value="eno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902:SF1">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00002">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00178">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enolase N-terminal" evidence="16">
        <location>
            <begin position="3"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase C-terminal TIM barrel" evidence="15">
        <location>
            <begin position="143"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="374"/>
            <end position="377"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="398"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMF10132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="438" mass="47365" checksum="42B8CF92EE96A2B5" modified="2013-05-01" version="1">MGISKIHARSVYDSRGNPTVEVDIVTETGLHRAIVPSGASTGSHEACELRDGDKSKWSGKGVTKAVANVNEKIAPALIKENLDVKDQSAVDAFLNKLDGTQNKTTLGANAILGVSMAVAKAAAAEKRVPLYAHISDLAGTKKPYVLPVPFMNVLNGGSHAGGRLAFQEFMIVPSQAPTFSEAMRQGSEVYQKLKTLAKKKYGQSAGNVGDEGGVAPDIQTAEEALDLITESIEAAGYTGQIKIAMDVASSEFYKTEEKKYDLDFKNPDSDKSKWVTYEQLADQYRSLAKKYPIVSIEDPFAEDDWEAWSYFYKNTDFQLVGDDLTVTNPEFIKKAIETKACNALLLKVNQIGTITEAIQAAKDAYGAGWGVMVSHRSGETEDVTIADIAVGLRSGQIKTGAPARSERLAKLNQILRIEEELGSNAIYAGENFRTAVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M3CDL0</accession>
    <name>M3CDL0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_47266</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="EMF11121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016909029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CDL0"/>
    <dbReference type="STRING" id="692275.M3CDL0"/>
    <dbReference type="GeneID" id="27906166"/>
    <dbReference type="eggNOG" id="ENOG502RY0W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026939_1_0_1"/>
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    <dbReference type="OrthoDB" id="408743at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
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        <property type="entry name" value="GPCR_2_secretin-like"/>
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        <property type="entry name" value="GPCR_GPR1/git3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42058:SF1">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 2 PROFILE 2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42058">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="7">
        <location>
            <begin position="61"/>
            <end position="250"/>
        </location>
    </feature>
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        <location>
            <begin position="258"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
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        <location>
            <position position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="EMF11121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="406" mass="44547" checksum="579816694E8F6AF3" modified="2013-05-01" version="1" fragment="single">MASTIDVASLNITFCPAPFLKDSDFPDTGGYLAGRYCGKLTGDLSCCLPCPVEKLVYTDRFNSLMQASHWLNIPSLALQCVLLITFIVLPKEVSHGSYHNFGLCIAIILLQLGFLIPLGTKPDLCHDTITPNDMYSDMSCAWTGALITTGAMACASWVMLRSLYTHLKICWDFKHERIFFWVAEIFGWGLPGLFLALTLPITGVSYRLGPTCVPNQKNSFVTWFGWLIAFGCIAALLTSSTTIFCLWVYLKDLGKKNKGGGGGGKSYGGNSTQQDDESIAPNTQSGWTSRNSTRKLAWSRVKVVLLAQWRSVLLSTLVIVMVLYYGTVFVKQTNTGLNAVDPDKQAAVTTWAICIVLNSGEKTKCEPLSHVLGLDENAVIAAWFIAGLVGTFTFLLMVRHSMITGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M3CEP5</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">SEPMUDRAFT_69217</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
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            <taxon>Ascomycota</taxon>
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            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EMF11516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016909856.1"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5421757at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF11516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="342" mass="39809" checksum="71A8DE206FECC4FC" modified="2013-05-01" version="1">MPSRSFKPKPKEAVKDQIPTPFVKAPSSLAPFLERLDPKLVHITHIDRTKAAVKKNIFLIPVLLNTTIAALLLWRLYHALPKYFILAKTILGYATSATVDKTSTTRKEQIWILMKRTLMMALDFLLFRFVGPWPLTFFFEQPANPCSYRWGLEGHFREKEVVVRVSRNWSAEDLMQGVKQGEENAFFKTRVLPAINPEEMRKTGYLMMNESWDLEFELMLDAHTLIKQKMLREEDVDKMVFVYMEGNGWVMWKWEGEDVIEGRRKKVVMFKEVLTKLGKESLFWRWTEIVEEERDADGGFTAKRQERVVERVKSEFEKEGVDFEEIVKGIGGLDEVPAGPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M3CFU1</accession>
    <name>M3CFU1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glycoside hydrolase family 28 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_149278</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 28 family.</text>
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        <property type="protein sequence ID" value="EMF12678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016905456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CFU1"/>
    <dbReference type="STRING" id="692275.M3CFU1"/>
    <dbReference type="GeneID" id="27902593"/>
    <dbReference type="eggNOG" id="ENOG502QRJW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OMA" id="TSRWIMI"/>
    <dbReference type="OrthoDB" id="187139at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF8">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_7G06410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 9 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF12678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="490" mass="53615" checksum="F75375E3FA8B70BD" modified="2013-05-01" version="1">MAGIVARLLAFSQAPLVAQNASNTHDLAPARTTATSSSGSEASAASQSPQECNSDRYDPYVCECLGHNGCWFPSEVHEGPPYSHDEPWPERSITCNIPAGNDPKGNDAPAIIKAFHDCRENGHIIFENATYYIGTKMNTTGLKDVTVELRGTMLWNTDIPYWLANSMPIGFQNQTAAWHLGGENLHFYGNGHGTLHGNGQVWYDYNKGESNLHGRPHSILITNTKNAVIEGLNFLQPQMWAMTVARSEKVLLQDIYVNATSADGNRNFRSNVNTDGVDTVYTNNITFLRWTIDNGDDSISMKQNSTNIYISNCTFYNGQALAMGSIGQYPGQIEVIENVTATDIRCVNTGYAGRVKSWTGKNKGFPPNGGGAGKGWARNITFMNFTLEDVNLAWAISQCTSYNRARGDCNSSDFQISSLHWGRTHGTLKGDRIATLQCSASAPCSNIHLFDNDLYALDQHLKPADSYLCEQVVNPTGFNCTGPCAGQCPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M3CJY9</accession>
    <name>M3CJY9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA ligase D 3'-phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_62200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762244.1">
        <property type="nucleotide sequence ID" value="XM_016909589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CJY9"/>
    <dbReference type="GeneID" id="27906726"/>
    <dbReference type="eggNOG" id="ENOG502SF29">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040687_0_0_1"/>
    <dbReference type="OMA" id="SIHQRKW"/>
    <dbReference type="OrthoDB" id="2588098at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014144">
        <property type="entry name" value="LigD_PE_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39465:SF1">
        <property type="entry name" value="DNA LIGASE D 3'-PHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39465">
        <property type="entry name" value="DNA LIGASE D, 3'-PHOSPHOESTERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13298">
        <property type="entry name" value="LigD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA ligase D 3'-phosphoesterase" evidence="2">
        <location>
            <begin position="101"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF14123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="401" mass="45441" checksum="CAF87F1A7B89863E" modified="2013-05-01" version="1">MVRLASLVRDVSPPTRKHASAPAVCSSSAHERGQTTPSDLKKSEAAAIEAHEIVIRDHLAYFVQHLSSVSRTNPKPRITIEQFADTYQRNQHSRGAHFVIHQHDHPVAGVHYDLRLQFSETSTVSWAIPYGLPGNANSLRPNRMAIETRVHNLWNNLIESASHATGSLLIWDTGEYEVLDRPQPRSYKNTDDELSDAESQDMKHEPQHERLIKAFQSRHIHLRLHGARLPKNYTIAMRLPSHNDRTDQPKKPARKRRRVDPAMARKPRTATSSDDDSDAEVAVSSIQEEIIEEEHLDAANASEDDEDTATRMNNAYTGASNTIGSIHQRHWFVSLDRPNSGFHKARSGPDSGRWVGDWEPFYVRGRDHEHSIVTGRNADDIMADEGVKSFVGRKMWRPIME</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M3CW25</accession>
    <name>M3CW25_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_152031</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756463.1">
        <property type="nucleotide sequence ID" value="XM_016907202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CW25"/>
    <dbReference type="STRING" id="692275.M3CW25"/>
    <dbReference type="GeneID" id="27904339"/>
    <dbReference type="eggNOG" id="ENOG502QT45">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006746_1_0_1"/>
    <dbReference type="OMA" id="SQFFYVA"/>
    <dbReference type="OrthoDB" id="546893at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050375">
        <property type="entry name" value="MFS_TsgA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702">
        <property type="entry name" value="L-FUCOSE-PROTON SYMPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702:SF13">
        <property type="entry name" value="MONOSACCHARIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="263"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="454"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="482"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="515"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="550"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="582"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="631"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="673"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="702"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="725"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="755"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="784"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="4">
        <location>
            <begin position="35"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF08342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="870" mass="94764" checksum="B975B516E1ED3529" modified="2013-05-01" version="1">MGDTYNDHGTLHGRSETTLAVTIAMLVLCTIFVALRMLSRVALIKKVSVDDYFMLLAWVITVGLCASICIGTRYGLGRHERQIPASWQPALRKSGYAFSVMYQPALMATKTSILAFYLTFSGAERLFRWACYTVLFVVNAGGLALTLVTVLQCDPVSAAFYAVPPPQAQCTDILTIYLSSIPLNIITDLAILFLPMPILTAMRLPKKQKLILVVTFSFGIFVAAVDVLRIHYLQSAATMRLSEIANMESMTSSRNSITTDSSFYLAFSFMWSAIECTVGIMCACVPGLKPLVARFMPSMLRSPDDEVSRFGSFSILDADAQTASSQVPDIPPDVHYHDFGRSAHPNEVEEGQRAVGIMDFLTTPDMNGFHSIERSTTALTNTSRHTAPRSPTFFDFVVMKQKKSLVHMTTKESIYPLAIVTVLFFIWGFEYGLVEVLNRQFQSVANVTTAQAVGIRSAFYCGYLVGPITVGRWTLKHWGFKACFPLGLSIYGCGCLIFWPAAVLTSWPTFLVTNFIVAFGLSLLEVSANPFILLCGPAQYAEIRLNLSQAVQAVGGIVAPLIASKAFYHTTANAPTLINTQWAYLGISLSTFALAVVYFYVPLPEATDAELEDSVERLDGANKAKFGEVHAIWYILGLGVFSQFCYVGAQEVIGTSFVSYLHTVAPELDTTNFFAIAHTAFAVSRFLAAGAGFWISPRVLLLMFYSGTIIFSALCTHFTGRTGVAMMIMVFFCEGPLFSLIFGQALRGQGRHSKFASVLVTAAIGGGAIFSPISSALVAHGRSVPYSLVVAVAAFSGGIVFAFGLNLSRTVRLVVDPLKEHSGSLFGSDDRPGSHSSRASRAFSLLSIAKHKRNSGCVEYRERKGSAPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2024-01-24" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M3CWB9</accession>
    <name>M3CWB9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_136805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF07961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756082.1">
        <property type="nucleotide sequence ID" value="XM_016902802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CWB9"/>
    <dbReference type="STRING" id="692275.M3CWB9"/>
    <dbReference type="GeneID" id="27899939"/>
    <dbReference type="HOGENOM" id="CLU_1289657_0_0_1"/>
    <dbReference type="OMA" id="CKSKDAY"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032894" evidence="1">
        <location>
            <begin position="17"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF07961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="214" mass="23675" checksum="0E12D684C5F7B756" modified="2013-05-01" version="1">MQLTVAFAAMLALASATSNGRFYGKNNPWPKKDCPTTKTCKAVYSTYYKEVPTYYEKTKTETVYKPYTTTIYIDKTLTKTSHLPTTSIGTTTLTYETEIPTKTPIVKTLTTTYLTTYWKDSKVRTTLTSEQPCTFVSNVPQLYTTVEKGSPKAIVTKKLETYVVTKKIPTMTKSPGTVTSTVCSAKEVCPTMIMTTGTTPTATTTRGPQAPGYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M3CX94</accession>
    <name>M3CX94_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_111237</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756853.1">
        <property type="nucleotide sequence ID" value="XM_016900906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CX94"/>
    <dbReference type="GeneID" id="27898043"/>
    <dbReference type="HOGENOM" id="CLU_816761_0_0_1"/>
    <dbReference type="OrthoDB" id="3938729at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032673" evidence="3">
        <location>
            <begin position="21"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF08732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="340" mass="37527" checksum="B573406528399A72" modified="2013-05-01" version="1">MFAPKMLAMLLVWMTLSCHALLVPAQVKREASELYSPTTLHARNELDDRAALTAHELEGIKYAEEGNLEMFNQYAREVALKSGDPELIEAANGPRSIEKRRGRGRGRGRGRGRGRGRGRGGYTPCTKNKQWHISPRSALGCWDRTYRAPRGRRDPHQHVISTTRSLLLLINSGHRAAAQAGAKTLVKKAHELDQAAMKADEVEKAAATKARLARDVTTVTALEPYAAAAVAVVPRSLGTNDLVEDGFLGINWHFLDSISAFISKCIITTLTRNAPRLLRLRLIACLAVVATVIVAVTVCAEGVLEPPAFLLRKSYTPVHPELAECRVEEENRRIDLRNHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M3CX99</accession>
    <name>M3CX99_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Taurine catabolism dioxygenase TauD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_151688</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756858.1">
        <property type="nucleotide sequence ID" value="XM_016906981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CX99"/>
    <dbReference type="STRING" id="692275.M3CX99"/>
    <dbReference type="GeneID" id="27904118"/>
    <dbReference type="eggNOG" id="ENOG502QWD7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041041_2_1_1"/>
    <dbReference type="OMA" id="GWKLPFW"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000009">
        <property type="entry name" value="Putative Taurine catabolism dioxygenase TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF56">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="4">
        <location>
            <begin position="95"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="370"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF08737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="398" mass="44985" checksum="3DD888F3733AE395" modified="2013-05-01" version="1">MAPAALVDQPTELPRFRYDNPSKAVFPDGIKTSGQLVPQYDQLKPYHDFPQEIVGETVWKPEDYQNHPERWVHRFSDDEIVEISKAADDFISSGTPMTGITKAKFPLPNMANFLEPMRKEILNGKGFILFKGFPVQEWGNHKSAVAYMGLGTYLGYFVSQNGLGHVLGHVKDTGADPTQIDKVRIYRTTARQFFHSDDCDIVGLLCIAKSLEGGESDIASVHHVYNILQKERPDVIKTLTTPNWYFDRKGEVSAGQEPYTKQPVLYRESGPNGRVYCKWDPYYVKSLSRFSDPGLIPALSPEQVEAAQVLEDTCMRHALHMILDIGDIQFLSNAHVLHSRTAYKDFPAPHPRRHLMRLWLATPEGEGGWQLPFEDSKHQKRGGVQVDDTPPRAPIDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M3CY38</accession>
    <name>M3CY38_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mitochondrial outer membrane protein porin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_152219</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic mitochondrial porin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756722.1">
        <property type="nucleotide sequence ID" value="XM_016907312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CY38"/>
    <dbReference type="STRING" id="692275.M3CY38"/>
    <dbReference type="GeneID" id="27904449"/>
    <dbReference type="eggNOG" id="KOG3126">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044399_0_0_1"/>
    <dbReference type="OMA" id="FKQPAFH"/>
    <dbReference type="OrthoDB" id="7827681at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008308">
        <property type="term" value="F:voltage-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07306">
        <property type="entry name" value="Porin3_VDAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001925">
        <property type="entry name" value="Porin_Euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743:SF70">
        <property type="entry name" value="GH26960P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION-SELECTIVE CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00185">
        <property type="entry name" value="EUKARYTPORIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00558">
        <property type="entry name" value="EUKARYOTIC_PORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0626">Porin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF08601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="31967" checksum="0F6A273439378584" modified="2013-05-01" version="1">MSNLFQSAEHKAERALAPLIPIPAFGDLSKAANDLINKDFYHTSQATLDVKLKAPSGTNVTIKGKQGFDGVTAGSIEGKHAIKPHGVTITQAWSTASLLDSKVELTDAVAPGVKIDLQNLWNPSKEGSAAQKVNLAFKNPNVHSRAFVNYATAKGNIDAIVDVVAGSDGFLVGGEAGYDVQKAAVTRYSLGLGYQTPSYVASIVGTQNLTQIAASYYQKVNTAVEVGAKAGYDVQAQKASGLELASKYKLDPLSFAKAKINDRGIAALAYSTKLNAGTTIGLGLSLDTKALNEAGHKVGVSLAFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M3CYE4</accession>
    <name>M3CYE4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_158858</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756827.1">
        <property type="nucleotide sequence ID" value="XM_016907809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CYE4"/>
    <dbReference type="STRING" id="692275.M3CYE4"/>
    <dbReference type="GeneID" id="27904946"/>
    <dbReference type="eggNOG" id="KOG0519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003731_0_0_1"/>
    <dbReference type="OMA" id="MRTHNEM"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF72">
        <property type="entry name" value="OSMOSENSING HISTIDINE PROTEIN KINASE SLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="583"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="10">
        <location>
            <begin position="965"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="449"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="500"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="918"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1012"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1116"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1012"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1117"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1129"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1141"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1177"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="1051"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF08706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1198" mass="129877" checksum="55CE8F49FF1D7873" modified="2013-05-01" version="1">MRIPIRKQLALLLIASSTLGLSVLAIATWLTNHDFVLSVAASRLRTTAVLKSAQIAYNLELMQTAATFLTTRTIIQQALERYNNGSNTAPDNWLLASSDLRATLGNVGPLTSPLILQTQIFSRNTSGPAGATSVLNETGPIAQIRLPWSDEQGNPVYLGDAGSGYPPSLYPNLTMSNDSAASSTASFNVTISGQATTNSISSYTISDDPTTGSTATYQGGTLGLRSTLILGPLSVNATFSLLSFTLPIVSNANNTNVIGWATVVGNARLIQLVQQDLRGLGTTGETLLLGPTDPTNNFPEGIIGIPDAARDASVQYMLPLNTTSKDRHPNHILGTENPPFPASAYPAVERAVLENNRGMDDVKSMLRTHNEANKSVSVGYSIVPTDLVDWIVVVEQARSEVWAPIYRLRRIILATLFAVVGFWTLLSYPIAHWAVLPIVRLRAATAQTIDPPRSHPSPASSDASSHHFTKVDTKSVDSRSANGKRKGFVETIARWRGKRNGSIHIEPRDDQRFRIPGKVPGKNKGRVQDEMTDLITTFNDMSDELYLQYSQLDERVRQRTIELEHSKKAAEAANESKTLFVANVSHELRTPLNGILGMCAVCMEESDLNKLKQSLGIIYKSGDLLLRTLTDLLTFSTNQVGHQVLKLDEREFYLRDLESQITALFGDQAREKGIALKVVFEDMPLERFSSPDQQPSLKDIALWGDIHRIMQMVINFTSNALKFTPADGFVTVTVRALSETPVRHRSNAGSTIRYSHGRIKDQAQPSPSADGTANFINPREIWHEQVDPVPCAPPGDDIYIEFDVRDTGPGIPEEQQRSIFEPFVQASAGLSRKHSGTGLGLSICLQLASLMRGTIGLTSTVGRGSTFTTKLPLRRIVGTASGRNSLTMKNSDRMPTMGERPTERVPTIAAMTARSPVSPVAAAPPDTAVPPPLTSTPSSQARAIGKAGKDIKAGKEAQQDFSNVRILVAEDNKVNQEVILRMLKLEKIFDVTIAHDGQAALDLIKASTLSSEASQDSDEQASSSNSAEDSVSSSSSTTSPRPHPYDLVFMDIQMPRMDGLTSTRLIRQHGYTGPIVALTAYAEQSNVEGCYQAGMDYFLAKPIKRPLLRKVLTDCCSSSSTTSGSTPKDASDDDAKKVSETDTTAKTTTATNGDGDKADGIQQTAEGIEMKTLAKDPQQQPNQSPKISPSSSEPTQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M3CYY8</accession>
    <name>M3CYY8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_150981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF09874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757995.1">
        <property type="nucleotide sequence ID" value="XM_016906521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CYY8"/>
    <dbReference type="GeneID" id="27903658"/>
    <dbReference type="HOGENOM" id="CLU_2694725_0_0_1"/>
    <dbReference type="OrthoDB" id="3647319at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032637" description="Secreted protein" evidence="1">
        <location>
            <begin position="39"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="74" mass="8513" checksum="336BDEF86EB3D94E" modified="2013-05-01" version="1" fragment="single">MCIFADWTGPDHGRRFAMQACPWMYAVLFLHWLETACARSQTSKADPQGGKVDGEFEHSRDIYVQATYGRRLVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M3CZ60</accession>
    <name>M3CZ60_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_151034</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF09944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758065.1">
        <property type="nucleotide sequence ID" value="XM_016906554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CZ60"/>
    <dbReference type="STRING" id="692275.M3CZ60"/>
    <dbReference type="GeneID" id="27903691"/>
    <dbReference type="eggNOG" id="KOG0519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_82_4_1"/>
    <dbReference type="OMA" id="CPWPDFW"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF72">
        <property type="entry name" value="OSMOSENSING HISTIDINE PROTEIN KINASE SLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAC" evidence="10">
        <location>
            <begin position="487"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="564"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="891"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="954"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF09944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1036" mass="116478" checksum="58490A32DBC86894" modified="2013-05-01" version="1">MIMKLQHDTEEPSEQEAEQESEQYRHRHQHHRHHHHEYQYRFQDQFQDQFQHQYPFLTGGSWTDSLPHTDHCNLFRNTDYAKTSLGPISDWDPALRCYVSMLFADSRPACVYWGVEDRIAIYNQEFSLLLGAMHPAFMGMSFYEGFPEIADAVRPVFEASVNTRHSMQLPHSSLFVSRNGFLEETFWINQFIPIPGPNGEIQGTYNTCVESTQHILHERQRLVMDQIAALTLHSVSETLAKIMEALRGNPNDVCMALLYTYDDADCLTDHDLHLCGSIGVPSGHQLAPETAQLRTSNAGLVPYFRQAKALGTPVVLRESDGSLSDVAALLNGVEWCGFNEPARNISIQELRSSAGDSLGFYVQGLNPRRPYDVDQRESVADLTRTMEATWMSSVSTEQAQLRERALELRATDSERRLKLMAKHAPIGLVQISMDQTIEWANDQFYDITGHDRTKPQMSEFYNAFPPEERVKVAASLKSLQYEGVEREVHELRLSRKWRPPGTDEEASAWMLTLGLPLHDEDGRVILTMGFLSDISHQKWSELVQTRSAAQAMQAKRQQEEFIDTTSHEMRNPLTAMTQLADGIAGCLKDDCARSVDDYRSIIEDNVEAAATILACAAHQKRVIDDVLILSRLESEMLSITPIPAKPSKVIADVVRMFSAECLVNDISISIIGDSSNEHLTQQPMLVDTSRLAQILINLLSNATKFVVNQHVRKITVTYGASLAHPPIFDTAFPMNSIEDEGEDPSNDALPDLHNDEERLYLYFVVTDSGPGMTDEEMSRLFKRFSQATARTHIQYGGSGIGLYVCRQLAGKQGGRICVGSRLGVGTSFGFYIESRLVEGIASAVSNGPATSGRLGLSRDQGYSRSDEVTSTADVLLAKRASDMRQQMRGFDLFLVEDNLINQRVLAKQLRSAKCTVTIANHGQECLDLLQRSNCWRDSSLATNDRIQVEAIILDWEMPVMNGLDCCRKIRELEATGQLTRHIPVILTTANVRLEQREHAEQAGVDFVLPKPFTVNDLLDKVWTMLNHETSEKSAPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>M3CZF6</accession>
    <name>M3CZF6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome biogenesis protein YTM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">YTM1</name>
        <name evidence="10" type="ORF">SEPMUDRAFT_158215</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat WDR12/YTM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758135.1">
        <property type="nucleotide sequence ID" value="XM_016907777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CZF6"/>
    <dbReference type="STRING" id="692275.M3CZF6"/>
    <dbReference type="GeneID" id="27904914"/>
    <dbReference type="eggNOG" id="KOG0313">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_0_1"/>
    <dbReference type="OMA" id="DHKYVEF"/>
    <dbReference type="OrthoDB" id="10251381at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110136">
        <property type="term" value="P:protein-RNA complex remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03029">
        <property type="entry name" value="WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012972">
        <property type="entry name" value="NLE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028599">
        <property type="entry name" value="WDR12/Ytm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855:SF11">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855">
        <property type="entry name" value="WD40 REPEAT PROTEIN 12, 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08154">
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    </dbReference>
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    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NLE" evidence="9">
        <location>
            <begin position="11"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="176"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="208"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="280"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="367"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="239"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF10014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="465" mass="49993" checksum="B0F7E4AE0AE0768A" modified="2013-05-01" version="1">MATSTEAQKQVKIRLSAKDESIALPQEVGELVISTEVKRYQLSLLVNNLLGTAQPTPFEFLINGQYLRTSLDEFLTENGISAETTLSIEYVKALSPPQYVASYEHDDWVSSVDILSESSAAANWANVTGSLPTSVASGSFDGALRVWNESQEILATGTGWHRGSIHATKWLSPTQIATAGTDRSVRLWDYALSGTAAGSAKLSPKLELLGHKGAIDSIAVHAPSSRILTASSDNRIGVWSSKKSEGPAYEAPAPSSTANKRRKISGPAISTPQRGALSYLEGHTQHVKDVVFDTRDPTVGYSASIDHSVKTWDLATATCVSTRSTNQSLLSICHLPEHTGILAGGALNRIDLIDLRASASKVAVLSCRGHKNWIRSISRDPESSYRFVSGSDDSTCRIWDIRSTSQEAAGGTVAKPVYTIDRESQTGKKVEQGSESSVYAVEWSKEIGIVAGGMDKMLQINRAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M3CZQ1</accession>
    <name>M3CZQ1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_151959</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF09151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757272.1">
        <property type="nucleotide sequence ID" value="XM_016907151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CZQ1"/>
    <dbReference type="STRING" id="692275.M3CZQ1"/>
    <dbReference type="GeneID" id="27904288"/>
    <dbReference type="eggNOG" id="ENOG502SJSX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047427_1_0_1"/>
    <dbReference type="OMA" id="YYMLEAY"/>
    <dbReference type="OrthoDB" id="3642468at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="130"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF09151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="414" mass="47570" checksum="19FD518987939254" modified="2013-05-01" version="1">MSMSTELAFVRAALRDRSMNVNVQPSLSSLSSAKTTSWSDPSAGVGTTAREEEEEAAAEEESYSVITPRQTAVKKTAARKTAAEKTAVAVDDDAPRIDTTEKLPLKSKKTDRAKKKHEKRLKRTTVKSDTKSFLELPTELLDEVLSYLAPSDVIRLQRLTKGTRKYIRDNEKFIAQSIMDRRYHVLARAFQCPVPFERLDARAQCSLLSSEWQDRSKLHRNSYYQIVKPLDPRKVCTCTTCMLAWNNLNIVLDLAYYQHHLNARIAIPMVPRGENPAWHADRQRENAAIVERAMYSPLYHAVILQTHLATTVGTLNRRYREVRVNKKTKTSHPKVLYHMSEEDISSGTDMFLERSGPPSTVIPYHRDMYYNLEAYVPNRAWSKEKQKWLYARAPHENDLQWIVSKFEPDRRGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M3D0P3</accession>
    <name>M3D0P3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Increased loss of mitochondrial DNA protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_165746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758169.1">
        <property type="nucleotide sequence ID" value="XM_016908186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D0P3"/>
    <dbReference type="GeneID" id="27905323"/>
    <dbReference type="eggNOG" id="ENOG502RZTE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113779_0_0_1"/>
    <dbReference type="OMA" id="FWLWIFI"/>
    <dbReference type="OrthoDB" id="5299849at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018815">
        <property type="entry name" value="Incr_loss_mito_DNA_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28029">
        <property type="entry name" value="PROTEIN ILM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28029:SF1">
        <property type="entry name" value="PROTEIN ILM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10311">
        <property type="entry name" value="Ilm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF10048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="174" mass="19484" checksum="9D5462A29EB8ECC8" modified="2013-05-01" version="1">MAIFTPYTLIRTISLFHITAAYFFLTAPRVLADQNVVYILGESMRINHATSMDKPSEATAFIAVILAFLGVADLTAANMNENTALEYWLSNVPVRLTFLFGLTGYVYLFKEDGVFGSGSAAAIGIGEPLQNSLVFSFGFFEIAMWFWIFNSLREEKGAVVRKRLEELKSQDDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M3D0V4</accession>
    <name>M3D0V4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GDS1 winged helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_150141</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759244.1">
        <property type="nucleotide sequence ID" value="XM_016905981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D0V4"/>
    <dbReference type="STRING" id="692275.M3D0V4"/>
    <dbReference type="GeneID" id="27903118"/>
    <dbReference type="eggNOG" id="ENOG502S2UH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036462_0_0_1"/>
    <dbReference type="OMA" id="YLNRTWP"/>
    <dbReference type="OrthoDB" id="4150221at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057511">
        <property type="entry name" value="WH_GDS1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25318">
        <property type="entry name" value="WHD_GDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GDS1 winged helix" evidence="2">
        <location>
            <begin position="92"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="201"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF11123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="420" mass="46115" checksum="5132A05D538B50E9" modified="2013-05-01" version="1">MQTRRKSLNLGDLGIVAAKRSRTQAPTPPETVIEGEEPPVKKPKRSHGSTSPTLGLMSPPRTTSIRCKEERPRRATELSPPPSPVTEGSSKIDTEGINDDIVVGTIQQIEKTGNRPHLVKELAAILATKLHCVEKSANPSALISSRLTAYLHRTWPTVSPCPLTKDLSPVHPRRLYFYLTTTPHQPIPDTVEQVPKPNRTISPSISSASAADMEDRFTRERQSLSPEVDLSSPELDEDTGADPRAPGGSYSARSSMSRDRASFAHSRRNASPPLETEERDFKQTASALYEEALKRRNSQQSQQDVNMDSQDASPGAEDMDSVTMSVEEDETEETAAMKNSAFAMELFGASVPSQHGMDLSSPVLGPQNNHALGRHEERMKLDLSGKEHLLALPEAALMWEGLQSPEDIELSELDDMLNAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M3D103</accession>
    <name>M3D103_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_10616</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758294.1">
        <property type="nucleotide sequence ID" value="XM_016900618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D103"/>
    <dbReference type="STRING" id="692275.M3D103"/>
    <dbReference type="GeneID" id="27897755"/>
    <dbReference type="eggNOG" id="KOG4161">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053907_1_1_1"/>
    <dbReference type="OMA" id="ATDWNGA"/>
    <dbReference type="OrthoDB" id="10248542at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045138">
        <property type="entry name" value="MeCP2/MBD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15074:SF0">
        <property type="entry name" value="METHYL-CPG-BINDING DOMAIN PROTEIN 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15074">
        <property type="entry name" value="METHYL-CPG-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="3">
        <location>
            <begin position="26"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF10173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="220" mass="25384" checksum="1FD8FED9EB64AD78" modified="2013-05-01" version="1" fragment="single">PCPPLDSPLFGIIQERTCHEPFWLIIATVFLNKTTGRQAAPTFWKIREKWNTPAQLAEADYDELFHMIKHLGFQHQRTKRLKLLAAAWEKDPPRKGRRFRTLHYPSKGDGKHFKSGQVIEGDVEDCAGALEIAHLPGCGAYAYDSWRIFCRDVLRGVEGEGEGKGEVFSFEPEWKRVLPQDKELRACLRWMWLKEGWIWDPVTGAKRRATPEEIEKANKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M3D1C3</accession>
    <name>M3D1C3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_91545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758409.1">
        <property type="nucleotide sequence ID" value="XM_016910559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D1C3"/>
    <dbReference type="STRING" id="692275.M3D1C3"/>
    <dbReference type="GeneID" id="27907696"/>
    <dbReference type="eggNOG" id="ENOG502SN1P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051520_0_0_1"/>
    <dbReference type="OMA" id="YFPGATF"/>
    <dbReference type="OrthoDB" id="4159781at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF10288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="343" mass="37704" checksum="8925643695D74D36" modified="2013-05-01" version="1">MVSSHRPAELSRGQSAASGPPSPASTRSDSNTRISATPDNIDFRFLNFSHPQDAKNAQTRRNVRSHVTTKQHEKQRQRVAEQARQTQQCSDQPSQTPSTSVSRNHSGESSTRSCSETETSSPEASSPSSPTASSPLSMLNPLEVYPEAWHSSLRPVMDHYCKYMAVDLPGTDEATRQTIRIHLLGLAFTDHATLHALMLVAAAHYSKLRGQGSHNINMLQLRGMAIQEVNRAMMDHGPRGRATSDRMIAAVAKMATFELLFGQREIFHTHMTGLQRMVSLRGGLQALGLNGMLERMLLWIDTNAAEITGSGLYFPPAAFKSSSGHPRADRRLFLLGLHDQAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M3D1D5</accession>
    <name>M3D1D5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein RER1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_150261</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the RER1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759424.1">
        <property type="nucleotide sequence ID" value="XM_016906057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D1D5"/>
    <dbReference type="STRING" id="692275.M3D1D5"/>
    <dbReference type="GeneID" id="27903194"/>
    <dbReference type="eggNOG" id="KOG1688">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074889_0_0_1"/>
    <dbReference type="OMA" id="GWYVVCY"/>
    <dbReference type="OrthoDB" id="448250at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004932">
        <property type="entry name" value="Rer1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10743">
        <property type="entry name" value="PROTEIN RER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10743:SF0">
        <property type="entry name" value="PROTEIN RER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03248">
        <property type="entry name" value="Rer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016013">
        <property type="entry name" value="AtER_Rer1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF11303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="189" mass="21900" checksum="09FB3A0F9E33EC9F" modified="2013-05-01" version="1">MDAPEPDTPFAAVSAQTTRFQQIYQSYLDKSTPYIAYRWIATGIVFLLFAMRIVFAQGWYIVAYALGIYLLNLFLAFITPKFDPSLDADTDMEDGVPAGQSSLPTKNDQEFKPFVRRLPEFKFWHSATRAVALSFACSWSEIFNLPVFWPVLVIYWLVLVILTMRKQIQSMIKYRYVPWDFGKTKYAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M3D239</accession>
    <name>M3D239_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Caleosin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_68549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the caleosin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759303.1">
        <property type="nucleotide sequence ID" value="XM_016909828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D239"/>
    <dbReference type="STRING" id="692275.M3D239"/>
    <dbReference type="GeneID" id="27906965"/>
    <dbReference type="eggNOG" id="ENOG502QQD0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062049_0_1_1"/>
    <dbReference type="OMA" id="WGGAFFE"/>
    <dbReference type="OrthoDB" id="640742at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007736">
        <property type="entry name" value="Caleosin-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31495:SF0">
        <property type="entry name" value="BINDING PROTEIN CALEOSIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G13750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31495">
        <property type="entry name" value="PEROXYGENASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05042">
        <property type="entry name" value="Caleosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF11182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="272" mass="31174" checksum="48D8B12CDD41D49D" modified="2013-05-01" version="1">MPQFKVTTDDVKAFLPDRSNGHSSAIPSEKRLGSANSNLITGLPSVPVTFERQPYHAGVNDVLQHPGTARANIAPSKESPRGTEGWAENHQHQTVLQQHCEYFDQDRDGVIWPFDTYRSCRGWGWNPLLSAIVMIIIHQGLSYPTCPSWIPDPSFRIWIKNIHKDNHGSASGSYDQEGRFRPQQFEDIFSKYDQGHKGGLTIGDLLRFHKGQRFAMDFWGQTATFLEWTAVYLLLWPDDGVMRKEDVRRIFDGSIFQHKADEYKRKQEAKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M3D3E4</accession>
    <name>M3D3E4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase family 128 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_149322</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760871.1">
        <property type="nucleotide sequence ID" value="XM_016905489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D3E4"/>
    <dbReference type="STRING" id="692275.M3D3E4"/>
    <dbReference type="GeneID" id="27902626"/>
    <dbReference type="eggNOG" id="ENOG502RXK9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040908_4_1_1"/>
    <dbReference type="OMA" id="SHKRGVC"/>
    <dbReference type="OrthoDB" id="43654at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071966">
        <property type="term" value="P:fungal-type cell wall polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053183">
        <property type="entry name" value="ASL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024655">
        <property type="entry name" value="Asl1_glyco_hydro_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154:SF10">
        <property type="entry name" value="ASL1-LIKE GLYCOSYL HYDROLASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11790">
        <property type="entry name" value="Glyco_hydro_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004033062" evidence="2">
        <location>
            <begin position="20"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="Asl1-like glycosyl hydrolase catalytic" evidence="3">
        <location>
            <begin position="364"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="224"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="244"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF12750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="591" mass="59290" checksum="9035BE1737985EA2" modified="2013-05-01" version="1">MSSSVKLSILALASSAVAARHGHVYGHHRLHASGTGGAAATGSAGLYPYPNANGTRVWGSTGMSVPTAYGSSSAVDAEHSTLHSTAYHTAYHTVTMKADNAAAVPSSAAAPAGYGSSSSLAAAQSGDSCAAVTVTYTEKVTATITEGQSIPSSTDSSPVDSTPVASAPGYSAPAYGSSSSIDASPVGSTPAASAPGYSAPMYNSSSSTGASPVGSTPVASAPGYSAPAYGSSSSTDASPVGSTPAVSAPGYSAPAYSSSAGTEASPAGSSVSAPAYSAPASTSSSSTAAPIPSSSSEDSPVTTAAASYSSASTSDAITATPYGGANKQGGVHLSLALGYPSASSTASAAASSSTSSGSSSGKRGLAYNDASLTSCFKGSREITWAQNWGSSSNGLSSDYTFIPTLWGTRSDFVDSWNENAKAAISSGSTHLFSFNEPDLPAQANLGYAAAATAYAQYMNPFKGQAQLCAPAVTNGGGDSMGLSYLKNFLSACTDCQIDCLNIHWYDSAENVDYFKSHVEQAIELANGKPVYISEFGCTGSDDQINSFLQEVMPWMDNNSNIAGYAYFMVESGNLLSGTEPSTYGRTYMSYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M3D473</accession>
    <name>M3D473_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">L-ornithine N(5)-monooxygenase [NAD(P)H]</fullName>
            <ecNumber evidence="4">1.14.13.196</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_141575</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-ornithine + NADH + O2 = N(5)-hydroxy-L-ornithine + NAD(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:41512"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78275"/>
            <dbReference type="EC" id="1.14.13.196"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-ornithine + NADPH + O2 = N(5)-hydroxy-L-ornithine + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:41508"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78275"/>
            <dbReference type="EC" id="1.14.13.196"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.196" evidence="4"/>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760815.1">
        <property type="nucleotide sequence ID" value="XM_016902969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D473"/>
    <dbReference type="GeneID" id="27900106"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020931_2_0_1"/>
    <dbReference type="OMA" id="YTRYFHA"/>
    <dbReference type="OrthoDB" id="3519933at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025700">
        <property type="entry name" value="Lys/Orn_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42802:SF1">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42802">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13434">
        <property type="entry name" value="Lys_Orn_oxgnase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF12694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="492" mass="54460" checksum="69CF7094D287CED8" modified="2013-05-01" version="1">MSGVEQATDASKSTSSLLERAGDDELHDIVCIGFGPAALAIAVALNDAIAAKDPSLRTLRPKVRFIERQPSYQWHPGMLLEDSKMQITFMKDLATLRNPRSHFTFVNYLHNQQRLVQFTNLGTMLPKRLEYNDYMRWCASAFEDVVDYHRSAGRIDAIESTSSSAAVQAFRVVSTCHKTGKTSELRAKHVIIAVGGKPYIPEALRFSHPRIIHSSQYMTEAASLFQNGQQPQRIAVVGAGQSAAEIFYDIPSKFPGAQSVLVTRRSALRPSDDSPFVNEVFDPSRTDDVFSQSPEIRAQAIAADRATNYGVVRLDLLEHLYSAFYTYRVKHLPEESWPHRIANHSTVTGVHAAKAGERSVLRLQIQNESQAYGRSNIPQKQELDVDMVIVACGYERNVHEDLMQDLQAMRPEADSAGWTVSRNYAVKFADDALECDRGIWLQGCNEKTHGLPDSLLSILSVRAGEVVDSILGGGPDGQRKTMVDSVLGAAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M3D4R2</accession>
    <name>M3D4R2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Membrane transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_148576</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761326.1">
        <property type="nucleotide sequence ID" value="XM_016905009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D4R2"/>
    <dbReference type="GeneID" id="27902146"/>
    <dbReference type="eggNOG" id="KOG0253">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_52_4_1"/>
    <dbReference type="OMA" id="TWRNYTL"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000171">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF4">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="399"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="429"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="485"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="514"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="77"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF13205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="543" mass="59212" checksum="7194B44B0F9D7A9C" modified="2013-05-01" version="1">MAATTGYGDDDKTKGGVLESHLSSGSRAYESTTGRSEDEYGLDKSDLLALEDVDPVLNKKMHLVNNAIDEIGMTGYQWKLFVLNGFGYAVDSLILLIQSIIAGQAAYEFKPGWDYGLTVASYVGMLVGALFWGLSADVIGRKYAFNVSLLISSVFCMVAGASPNWIVLGLFVSLAAFGAGGNLVLDTAVFLEYLPSKDQWLLTLMAAWWGLGQLVAGLFAWAFIPNYSCPGDPVETGVPCNWDTNPGWRYMWFTNGALIFLLSILRITVIRLRETPKYLVGEGRDAEVVDTLQFIAKKYNRPCSLTIEDFQACGVTGSYLRRGSGAAHAKSKFSFGEVGVHLTGLFSTKKLALSTSLIWFSWLLIGLAYPLFNVFLPVYLKTRGAQLGGLSPNEVWRNYAIANLCSIPSPILAGYMCKSRFFWGRRGTMVIGALVTMAFFFSYTQVKTNAQNFGFTCAISFCLNIYYGTLYAYTPEVLPSAHRGTGNGISIGFNRLMGIMSAVVATYADTSTPVPIYICATLYVVMAAAAIAFPFEPMGSRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M3D504</accession>
    <name>M3D504_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">DNA replication complex GINS protein SLD5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_64055</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The GINS complex plays an essential role in the initiation of DNA replication.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GINS4/SLD5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761401.1">
        <property type="nucleotide sequence ID" value="XM_016909667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D504"/>
    <dbReference type="STRING" id="692275.M3D504"/>
    <dbReference type="GeneID" id="27906804"/>
    <dbReference type="eggNOG" id="KOG3176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071893_1_1_1"/>
    <dbReference type="OMA" id="ILETAWI"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071162">
        <property type="term" value="C:CMG complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd11711">
        <property type="entry name" value="GINS_A_Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21692">
        <property type="entry name" value="GINS_B_Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.60">
        <property type="match status" value="1"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR21206">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PriA/YqbF domain"/>
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    </dbReference>
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    <keyword evidence="4 6" id="KW-0235">DNA replication</keyword>
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        <location>
            <begin position="60"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="DNA replication complex GINS protein SLD5 C-terminal" evidence="8">
        <location>
            <begin position="174"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008187"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00014804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF13280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="225" mass="26004" checksum="2D617C1247524750" modified="2013-05-01" version="1">MDEIDISDILASVSAPPLDPRAVDLQCLTRAWINERTAPDLLPYPADLITRSNEGIKRQIQVIEDMTGSMDPSKNFTLIILQTELERMKFLIRSFLRARIAKIDKFPIHYRQILQQTDPDEQQQPLLSTLESQYLEAHQALLTQHYHSSFLSLFPQHMHKMDDTQGGVSMVDKPDEDSAVFCRVLRDCYVERPVYGGIDLARGDIWVLRWRTIAERVRRGDVELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M3D581</accession>
    <name>M3D581_SPHMS</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">SEPMUDRAFT_132657</name>
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    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Sphaerulina</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761456.1">
        <property type="nucleotide sequence ID" value="XM_016902506.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="27899643"/>
    <dbReference type="eggNOG" id="ENOG502T2BP">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099966_0_0_1"/>
    <dbReference type="OMA" id="RNDFHED"/>
    <dbReference type="OrthoDB" id="6255506at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF13335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="247" mass="27522" checksum="3A27DE697A2E8930" modified="2013-05-01" version="1">MTDMADTTTRRAHDRSSGKIPLSVILNEIEPEPLPRTAGPPSSSGGGSSGGGYQHHHHHYDYPPQPTTTTTTSTTTTTTTSSRSHASSPTTSFGSPPPPLFLTGSNAHSPILHRDPFHAYGKDKPSSVSREQRSQAGSWSDSSMTDRRPRAPRPSYSEEQKFFIMYARIIRDNTWPEIEDRFEKLFGTRTKGGLTSVYYRVRREWGLMEVLKSGPGSYAADCREVEQRATNFSREYLSQIGYLPSIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
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    <name>M3D5Q5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Eukaryotic rRNA processing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_64427</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EBP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016909679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D5Q5"/>
    <dbReference type="STRING" id="692275.M3D5Q5"/>
    <dbReference type="GeneID" id="27906816"/>
    <dbReference type="eggNOG" id="KOG3080">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036007_0_0_1"/>
    <dbReference type="OMA" id="DAHKGRD"/>
    <dbReference type="OrthoDB" id="443772at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000280">
        <property type="term" value="P:nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008610">
        <property type="entry name" value="Ebp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13028">
        <property type="entry name" value="RRNA PROCESSING PROTEIN EBNA1-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13028:SF0">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EBP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05890">
        <property type="entry name" value="Ebp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="157"/>
            <end position="297"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="157"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
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            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF13480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="297" mass="32974" checksum="39772856E1198B05" modified="2013-05-01" version="1">MSDESESDSEIENDPADNDEDEAEEQDEDEEDIALSDLESLASEDKEDVVPHQRLTINNTAALARSLKSFALPASLPFSAVQAITSEDPVDIPDVEDDLNRELAFYRQSLNAVTEARVKLKAEGVSFSRPTDYFAEMVKSEEQMGKVRAKLLDETARKRASSDARRQRDLKKFGKQVQVAKLQERQKEKTATLDRIQTLKRKRQGADLATNETDPFDVALEDAATTAAKDKADRRAKGDGARKRQKKDEKFGFGGKKRFGKSNDAKSAADDSGYSVRKMKSGGKGKPRPGKSKRSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M3D6H3</accession>
    <name>M3D6H3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">TPT-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_64405</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761585.1">
        <property type="nucleotide sequence ID" value="XM_016909678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D6H3"/>
    <dbReference type="GeneID" id="27906815"/>
    <dbReference type="eggNOG" id="KOG1441">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033641_3_0_1"/>
    <dbReference type="OMA" id="CHMAACA"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="330"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="9">
        <location>
            <begin position="56"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF13464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="365" mass="40316" checksum="3873942F3F3164CE" modified="2013-05-01" version="1">MADAEKHRDSLSLEPHDYEKVGLLAQQQQKQQHDIESQAAIETPHEYQASSTKKFLCLALYFALNLGVTLSNKAVLQSAQYPWLLTAVHATTTSFGCFILRRLGVFHCTKLSSRDNLKLVAFSCLFTANIATSNVSLGLVSVPFHQVLRSTVPIVTILIYRWIYNRHYTRQIYLTMIPLISGVSLATFGDYYFTPTGFALTFTGVLLAAIKSISSNRMMTGTLHLSALEILYRMSPLAAAQSLVCAGMIGEVGDARREFFASGGRLFMTEKGNGFVMMLVLNALMAFMLNGISFYTNKIAGALTISVCANLKQILTILLGIVLFRVHVTPVHGLGMVVALVGAAWYSKAELDAKRERERSLDLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M3D6T2</accession>
    <name>M3D6T2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_43441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761705.1">
        <property type="nucleotide sequence ID" value="XM_016908895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D6T2"/>
    <dbReference type="STRING" id="692275.M3D6T2"/>
    <dbReference type="GeneID" id="27906032"/>
    <dbReference type="eggNOG" id="KOG1902">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121504_0_0_1"/>
    <dbReference type="OMA" id="WSTIRAN"/>
    <dbReference type="OrthoDB" id="6103986at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990247">
        <property type="term" value="F:N6-methyladenosine-containing RNA reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21134">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007275">
        <property type="entry name" value="YTH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045168">
        <property type="entry name" value="YTH_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357:SF3">
        <property type="entry name" value="YTH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357">
        <property type="entry name" value="YTH YT521-B HOMOLOGY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04146">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50882">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YTH" evidence="1">
        <location>
            <begin position="5"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF13584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="183" mass="20655" checksum="CB30BE300DE652B9" modified="2013-05-01" version="1" fragment="single">CDIGVRYFMIKSWNHDNVYEAQRTNVWATQEKNEEMLTHAYKTSRHVILLFSVNKSMAFQGYALMTSAPDPDIQKPSFTRRLNWATSNAFTLQWLAKTPIDFQLVGHLKNTFNIDEDTGEAHAVLVGRDGQEINADAGMGVLWFLDEAEAEAEAYRKSGKGNGILSWKPPLWSAEPERASCGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M3D763</accession>
    <name>M3D763_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_148928</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761840.1">
        <property type="nucleotide sequence ID" value="XM_016905234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D763"/>
    <dbReference type="STRING" id="692275.M3D763"/>
    <dbReference type="GeneID" id="27902371"/>
    <dbReference type="eggNOG" id="KOG4773">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014957_1_0_1"/>
    <dbReference type="OMA" id="FICAHHN"/>
    <dbReference type="OrthoDB" id="548867at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902494">
        <property type="term" value="C:catalytic complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000747">
        <property type="term" value="P:conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051130">
        <property type="term" value="P:positive regulation of cellular component organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05992">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06890">
        <property type="entry name" value="PX_Bem1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11879">
        <property type="entry name" value="SH3_Bem1p_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000093">
        <property type="entry name" value="Protein kinase activator Bem1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035550">
        <property type="entry name" value="Bem1/Scd2_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035549">
        <property type="entry name" value="Bem1/Scd2_SH3_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051228">
        <property type="entry name" value="NADPH_Oxidase/PX-Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15706:SF2">
        <property type="entry name" value="SH3 AND PX DOMAIN-CONTAINING PROTEIN 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15706">
        <property type="entry name" value="SH3 MULTIPLE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="34"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="162"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="6">
        <location>
            <begin position="303"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="PB1" evidence="7">
        <location>
            <begin position="533"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="100"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="433"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="433"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="448"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="468"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="488"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="515"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF13719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="629" mass="69316" checksum="68D6A3D2B8106417" modified="2013-05-01" version="1">MKFRRSVKSDKHDSAGATKTPLFVPQKDAIAIEPPKKVIKAIYDYNAPPDSHMYLSFSAGDFLHVVSRESDPDWYEACNPLRNERGLVPVKYFENVHKTVRDSDDSSRSINSTTHDSGYAEGSTPPATTTTAAPRMPANMNGMGPTANMPGHRATPSFGKSPAGIYGIVSYDFHAERPDELDAKEGEAIIVIAQSNPEWFVAKPITRLGGPGLIPVSFIEIRDMVTGRAAEDPLEAVRAAGIPRVEEWKKMAAEYKNTSIPLGTVSTTAVGTMDQAMGRMSLQQQNGSSMHSRQASIATQQQQNMFAPLRASVPRYTYADDKFHFVVECKLANNCHYDLSRIYEDFYELQINMINAFPEEAGQTPGKPRILPYMPGPVKYVTDNITEGRRANLDEYLRDLLQLPQHITHSSLVRGFFALREGDYEVDPATIDLNEHARPSDGPHRDSQVSMASGQSALHQPYPGQAGQARTHQYTQSQASNNGGLHRPQPSQASASFSSQSPGPGGLAAPPPVSRQHTNVSHTTVNSTASTGPVKVKAWFDRDTCVVIRMPARGQFGFEDLRKKIVERRKLEFGEAAELEAEDLDIEYRDEKDGEYYRLEGDEDLDIAVERNEKLTLAVRAAGGPPAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M3D7Z4</accession>
    <name>M3D7Z4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PPP4R2-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_148052</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPP4R2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762406.1">
        <property type="nucleotide sequence ID" value="XM_016904668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D7Z4"/>
    <dbReference type="STRING" id="692275.M3D7Z4"/>
    <dbReference type="GeneID" id="27901805"/>
    <dbReference type="eggNOG" id="ENOG502SBSZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024587_2_0_1"/>
    <dbReference type="OMA" id="PIPWLQN"/>
    <dbReference type="OrthoDB" id="341898at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030289">
        <property type="term" value="C:protein phosphatase 4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015267">
        <property type="entry name" value="PPP4R2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16487">
        <property type="entry name" value="PPP4R2-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16487:SF0">
        <property type="entry name" value="PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09184">
        <property type="entry name" value="PPP4R2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="50"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="270"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="314"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="404"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="270"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="314"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="481"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF14285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="536" mass="56679" checksum="B3E0B1577CE3D014" modified="2013-05-01" version="1">MLSEEQLLETAASDGSLDITEWPRVLESLLQRLHDIVYNEFPIPQLSLHEAAPQHPPIDPEVVASTPPPRIPTSDVTDVTESSLPGPESERPPDSQSSSKENEAPVVNHAAGRPLAAPRGFEVTTDSQRTEAVPSPTVLTDGMQLSVQGTLPPELLSMYQSSTKILQYDFAESPPYTIQRLAELVLRPKRHYRFLPAYLRALDRIVSVSSPLTDFPLPTLRVPANGGFLTNGEVQVNGVSERDGLGSDESLGGALLTPIPWLRNQTGILASSSGTDSNSQGELHSESTEMVDGPHGPGGIETVSVTVNGIHSTGVPQQQVTSSPIASPTLSEQSDASTGSASSTEAQLREQGAVTQGELLRQEQEAGVVPMSAAGQPRRVLHYTGAVGRESASAVPSITEAALDEGMGEQPHARGPEEIGDVDMGPQRRPGDGGPALDLEAAVGRGRSKSPMPDIGDAFPAAQSDDEVMGEPGAPGQDSQDVDKDIEQLKRAMDQEKEQEAKDADGDVMVADVDGNPVEQKTDGDNQPGAVDATTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M3D8V4</accession>
    <name>M3D8V4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ER_lumen_recept-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_148242</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762691.1">
        <property type="nucleotide sequence ID" value="XM_016904796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D8V4"/>
    <dbReference type="STRING" id="692275.M3D8V4"/>
    <dbReference type="GeneID" id="27901933"/>
    <dbReference type="eggNOG" id="KOG3106">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041571_0_0_1"/>
    <dbReference type="OMA" id="CILIWAI"/>
    <dbReference type="OrthoDB" id="7694678at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046923">
        <property type="term" value="F:ER retention sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000133">
        <property type="entry name" value="ER_ret_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10585">
        <property type="entry name" value="ER LUMEN PROTEIN RETAINING RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00810">
        <property type="entry name" value="ER_lumen_recept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00660">
        <property type="entry name" value="ERLUMENR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="248"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="300"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="316"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="343"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF14570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="374" mass="42040" checksum="46D02FB3865AF11D" modified="2013-05-01" version="1">MASVFHMNVFRILGDVSHTASKCILIWAIHSNKSAEGVSLLTQLLYCLVFTTRYLDLFWVPPWFSWWNFVLKLFYLATSAYIVFIMMRVFARTREKEYGWKLAIWSLAGSTVSAPLVCLLFEGWKRSTLSELLWTFSIILESVCVLPQLLLLRQTSVPTVLDSFYLVTLGSYRFFYILNWIVKMFSANEHVDATSVIFGLIQTALYVDFAWVYWSRQRVKLRYGGVVDSDDLSKSFIVKRFIGKRGNQNSNEDDDITEEEDRLAEQENGNIRPGATRSPSDRWGARGISVSADDTLQEHLDHSSRDAQMVDPSHFEDDDDDDDDVDNVPPPPAKDPAPHSKASESASSAGSSSAAAAAAAVPDGESSSAAEWDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M3D9G5</accession>
    <name>M3D9G5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_116027</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762886.1">
        <property type="nucleotide sequence ID" value="XM_016901215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D9G5"/>
    <dbReference type="GeneID" id="27898352"/>
    <dbReference type="HOGENOM" id="CLU_834624_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF14765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="333" mass="37794" checksum="DE48B8D5F09FB389" modified="2013-05-01" version="1">MPSLMQRNQSERSYLREPLTNSFLDVFGSNARLDVGLLGGAEAVCAMIDTREENLYIGDPSEGETKTELAVPTIDNDNQWCNTGTIIHPLYIVISFVAKAHMLWAISRHFPPSSLISPYDHHTTPRHKPRTSSQQQQQDQSRESAAAVTTVTTAKRMAWGVVWFLVSAAREGRSLRVRVPWPAAFLLFPFGGLLLSLFLFLDDREFVCRIHLFGEVLSLLRQYFCSGAAARLDRLREPIALSLLSFPPSSHTILHVDKYCFRGVRRLCDALGRYGFPHAETLQVFFCDFEVLSRLIYDEDTRRLSVDVMAYDPGEALRAPAHWLWRFSVAKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M3DAQ1</accession>
    <name>M3DAQ1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">UPF0052-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_146939</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF14914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763035.1">
        <property type="nucleotide sequence ID" value="XM_016903976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DAQ1"/>
    <dbReference type="STRING" id="692275.M3DAQ1"/>
    <dbReference type="GeneID" id="27901113"/>
    <dbReference type="eggNOG" id="ENOG502QUXN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019029_3_0_1"/>
    <dbReference type="OMA" id="IHLITPF"/>
    <dbReference type="OrthoDB" id="10267139at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043743">
        <property type="term" value="F:LPPG:FO 2-phospho-L-lactate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07187">
        <property type="entry name" value="YvcK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10680">
        <property type="entry name" value="CofD-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002882">
        <property type="entry name" value="CofD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038136">
        <property type="entry name" value="CofD-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31240">
        <property type="entry name" value="MATERNAL EFFECT EMBRYO ARREST 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31240:SF0">
        <property type="entry name" value="MATERNAL EFFECT EMBRYO ARREST 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01933">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142338">
        <property type="entry name" value="CofD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF14914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="480" mass="51843" checksum="CC9F44A9CABC6B65" modified="2013-05-01" version="1">MQAHDFAMRLEPSASRSISPALAATTRGGIVVFSGGSAANNLVDVFNDIREANNAALSYVIPISDNGGSSSEIIRVFGGPGIGDVRSRLVRLIPDEGDEAKAIKSFFNYRLPKTYAQSRAEWLEIVEATHPLWLGISSPKKELIRSFLNSMNLEIVKRLRPTSRFDFSGAAIGNLFLTGARLFTGSFESAVYLVSSICGIPAAVSILPVLNTNFAHHIAAKLADGTVITGQNNISHPSAPAASVTHIPVSPTQLLQAETEEHDKVEDANMPGTHPELRKPAIAFSKEGEEKLPARIERLFYINPYGQEITIPANPRVLEAIKNSSCIIYSIGSLFTSLVPSLVLKGVGAAISSPVIRTKILILNGTLDRETGPPSNPFSAMDFVATIVHACTTSQARPHAQPHDYWQYVTHVIHLDGPTSPVVDKSAFNKIGIETMRVYGRSDENGKGGRYDVKALTQALEAVIGRKDPRGMSRRNTAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M3DBM0</accession>
    <name>M3DBM0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_147326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763566.1">
        <property type="nucleotide sequence ID" value="XM_016904232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DBM0"/>
    <dbReference type="GeneID" id="27901369"/>
    <dbReference type="HOGENOM" id="CLU_1670481_0_0_1"/>
    <dbReference type="OrthoDB" id="3648789at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF15445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="158" mass="18278" checksum="6C6000CB18392885" modified="2013-05-01" version="1">MPIDAAFAGLFATGLTKALDTQIGEKLCHHLGNATIKDEEAYRKQKKSREEKRHSSSSYASESSRHSSDHDRRRSLDDAAPRRRPAPAELKRHSSSYYNPEQRGSRRTGSRRKHRRPRRISDAELDDMAEEELLREESRAAHEEKMESFREAKKSYEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M3DBM9</accession>
    <name>M3DBM9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_105711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763576.1">
        <property type="nucleotide sequence ID" value="XM_016900586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DBM9"/>
    <dbReference type="GeneID" id="27897723"/>
    <dbReference type="HOGENOM" id="CLU_790278_0_0_1"/>
    <dbReference type="OrthoDB" id="3645690at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF15455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="351" mass="39608" checksum="9C84FECC1DB7BDFC" modified="2013-05-01" version="1">MPPTTRSQTVHHRVQTVHRAQTVHRAQTVRYRAQTVRHRAQTVRHRAQAIKKRAVGATTSITPDEICHISMLYPVPEVFTMFLTSCTASEIFQLRQVCQHWKAMIDQSSPVQESLFLRPRRVTNVLELKPDHGPETTTVQGYLVTGKVTRPSQLVDGEKYSVPAEWNDVICVPSRFGHGMEMDRRVTMGEWIQLKDELVQIWIEEAVAIEWDKYSKTKNKEAPDVSTLPESDPPGPGRHQHMLGGGSGKTLHKTQLDMFLTQPPVKSVYVAHFLAGHQRVTNPTGLRLRDVLTALEPGMGVKRNFFDCWNPMAAERKGLGMNLNGAFDAGLEGMVFMGADDWKEVDRRAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M3DCE4</accession>
    <name>M3DCE4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major royal jelly protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_60859</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major royal jelly protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763836.1">
        <property type="nucleotide sequence ID" value="XM_016909543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DCE4"/>
    <dbReference type="GeneID" id="27906680"/>
    <dbReference type="eggNOG" id="ENOG502QVUM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031076_0_2_1"/>
    <dbReference type="OMA" id="IFRMRID"/>
    <dbReference type="OrthoDB" id="7776143at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017996">
        <property type="entry name" value="MRJP/yellow-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009:SF18">
        <property type="entry name" value="PROTEIN YELLOW-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009">
        <property type="entry name" value="PROTEIN YELLOW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03022">
        <property type="entry name" value="MRJP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032910" description="Major royal jelly protein" evidence="4">
        <location>
            <begin position="18"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF15715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="435" mass="47480" checksum="0C302209548F4D11" modified="2013-05-01" version="1">MWTTGIACLLIASRVAAQNATFETPAGTITTILRVDNGTFGPAVEEVHYYYDQFPIGIAAASDGRLFASYTRGDYVYTLGVITNKTAEEPYPSAELNLPPDQLNTTWNGIPFGSGNASAFISVQALYITSPGAGRPETLWALDTGRPTVHNAAGEPSMPYAQPGGPKLVAISLQNNTIYQTYTFPADVHYPDSYLNDLRFDFNPNLSGTSGKGIAYLVDSSNEGRPGFIMVDLGTGESWRRLDQDGSVLRGLNAVPSYYGAPKYLDMKGMGTNWQKEGLDGINLSDDGQRMYYSPLSTNYLWSIPTANLRLKISECASAEVFAHANVSNHGQRGGNANGFEGDTNGYIYQLMPEQNAVYYFDPTDGLTKPFARDPRIIWPDGGSVSTSGYLYLNINQLPFQPDWNNGTDLRLHPGAILRVKLPNGGKKVTSLYDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M3DCI6</accession>
    <name>M3DCI6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_123800</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763645.1">
        <property type="nucleotide sequence ID" value="XM_016901863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DCI6"/>
    <dbReference type="STRING" id="692275.M3DCI6"/>
    <dbReference type="GeneID" id="27899000"/>
    <dbReference type="eggNOG" id="KOG1414">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_853026_0_0_1"/>
    <dbReference type="OrthoDB" id="295274at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14687">
        <property type="entry name" value="bZIP_ATF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000837">
        <property type="entry name" value="AP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23351:SF24">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23351">
        <property type="entry name" value="FOS TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="5">
        <location>
            <begin position="130"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="45"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="230"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="49"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="129"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="230"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF15524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="326" mass="35639" checksum="92985CF8B412E637" modified="2013-05-01" version="1">MPCAELDHSIFLDPTLGQSPASTPWMQEQPRQDFHLQVSQAEILAGRASSVSQQHGQITPPDDNSPTVSGNASHQPPQRVSGGAPPMNAKSERARNAANQRHAKAKKARKDSVQSRKLDSPIDEEGEEVDGKREKYREKNRVAASKCRAKKKMHTEDLEESARQIMATNSKLRAEERELRDVFSSLRHLALSHDSTQGCKCSAIHMYNNHKANEAARTAAMGLIGMGVSFQNNPSPSTESDMSNLNSPQFGPESRAQSFSTSRPRSLAQHGRDQPMGEQVGYLVPGTVSEPRRQSQSAQHVGVLDAAGDCALGPTNETEDHSMELC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M3DD11</accession>
    <name>M3DD11_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_124070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764016.1">
        <property type="nucleotide sequence ID" value="XM_016901880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DD11"/>
    <dbReference type="GeneID" id="27899017"/>
    <dbReference type="eggNOG" id="ENOG502SKEA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024756_0_0_1"/>
    <dbReference type="OMA" id="HGAYHYI"/>
    <dbReference type="OrthoDB" id="446809at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF15895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="490" mass="55229" checksum="88179DB64AAC1516" modified="2013-05-01" version="1">MELVIIGFGPVAGYKYSRCIHNAIVHGNLNRYHIIDRECQQQQVEARLAKLPVQPASCTYIPENVLRDGTDSGIGWLVQHGLLTNDGTRKKIVLTTEPQSHDAYIRHALAQHFDILVSKPLILPIKDGVLDHRALMPGVHAIAKASVEAGVHSAMLCLGRFHEIYEKKLRQPVAMMMQRLQTPITSVHIKTASGVWNLPSEFSQREDHPYKYGYGMLMHGAYHYIDILARLLLLNRQLFPEEEFFITLQGFSAGPHDQRMRIGNLEPNTSGYRPEFSELQDGLPYGETDIVASYALRFRSSGRVLTLGTISLEQTTPGMRSWGPFPEVPYNINGRLHCTDIDVRLGTAFSIATNVTKHPIQARLGDTDVRGVNSATVVTRANARIARTQGFIRQETFERPYGKSYSYTAETEIFERWLQDKPTYSDLQSHVPSCAILDGLLKLAAADWRGDIEVDFDYPAPECPKVSQYDDPWYAYMADDVAFSSEHPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDN9</accession>
    <name>N1QDN9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Replication protein A, subunit RPA32</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_128243</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the replication factor A protein 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757742.1">
        <property type="nucleotide sequence ID" value="XM_016902204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QDN9"/>
    <dbReference type="STRING" id="692275.N1QDN9"/>
    <dbReference type="GeneID" id="27899341"/>
    <dbReference type="eggNOG" id="KOG3108">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051033_0_1_1"/>
    <dbReference type="OMA" id="SFGNKRY"/>
    <dbReference type="OrthoDB" id="25571at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04478">
        <property type="entry name" value="RPA2_DBD_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040260">
        <property type="entry name" value="RFA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014646">
        <property type="entry name" value="Rfa2/RPA32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014892">
        <property type="entry name" value="RPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989">
        <property type="entry name" value="REPLICATION PROTEIN A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989:SF16">
        <property type="entry name" value="REPLICATION PROTEIN A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08784">
        <property type="entry name" value="RPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036949">
        <property type="entry name" value="RPA32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Replication protein A C-terminal" evidence="7">
        <location>
            <begin position="184"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF09621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="271" mass="29461" checksum="00CB64B702561FA7" modified="2013-06-26" version="1">MDYGYSTTSYGAQGGNSGGGFMPGSQNNENSASTKRTYGKDTLRPVTIKQLLDAHHPHPDADHFIIDDSETTQVTFVGQVRNISAQTTNVTYKVDDGTGLIEVKVWVDADNFTGEEESGAVKKDKPVEQGYARVWGRLKQFNNKRHIGAQYIRAIEDHNEIAYHFLEATVVHLEFAKGPLDQLQANGQTGQQATTDSGGSGSNFSGVSATARKVLQVLKTNGNTNEGLHAQMVAQLTGLELVEVYKAGDELMGMGMVYTTVDDLTWALLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1QE39</accession>
    <name>N1QE39_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alcohol dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="9">1.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SEPMUDRAFT_150637</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a primary alcohol + NADP(+) = an aldehyde + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15937"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:15938"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:15939"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.2" evidence="9"/>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758702.1">
        <property type="nucleotide sequence ID" value="XM_016906303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QE39"/>
    <dbReference type="STRING" id="692275.N1QE39"/>
    <dbReference type="GeneID" id="27903440"/>
    <dbReference type="eggNOG" id="KOG0023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_20_2_1"/>
    <dbReference type="OMA" id="CDDYIAT"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008106">
        <property type="term" value="F:alcohol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000158">
        <property type="entry name" value="Zinc-binding alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="13">
        <location>
            <begin position="37"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="12">
        <location>
            <begin position="178"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMF10581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="340" mass="36467" checksum="0F6116ADBA39557C" modified="2013-06-26" version="1">MFFVSSLSFHPSSISINNPTLTIHSFFFFFKIGSGWGPTSYPIVVGHEIVGKAIRVGSAVSQSGEGASAIRVGDRVGVGAQAGSCLRPDCAQCTNSEEQFCKNNFVMTYNGTWPSGATAQGGYAKYWRGAGHFVFRIPEEIPSEEAAPMLCGGVTVYSPLKQNGVGPGKRVGVIGIGGLGHMAIMFAKALGAERVVAISRNDGKKSDALQMGADELIATDTDEEWSQKAANSLDVIICTVSSPKMPFGEYLNLLDVGGTFVQVGAPDDVLPPFVAMALIMKKVKIVGSLIGSPAEIREMFEVAARQKVKPWVQKRAMKDANQVILDFEAGMPRYRYVLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1QE49</accession>
    <name>N1QE49_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glutathione-specific gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="1">4.3.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_69892</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.3.2.7" evidence="1"/>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758732.1">
        <property type="nucleotide sequence ID" value="XM_016909880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QE49"/>
    <dbReference type="STRING" id="692275.N1QE49"/>
    <dbReference type="GeneID" id="27907017"/>
    <dbReference type="eggNOG" id="KOG3182">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070703_0_0_1"/>
    <dbReference type="OMA" id="DHREKDG"/>
    <dbReference type="OrthoDB" id="1933483at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003839">
        <property type="term" value="F:gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061928">
        <property type="term" value="F:glutathione specific gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.10:FF:000021">
        <property type="entry name" value="Gamma-glutamylcyclotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006840">
        <property type="entry name" value="ChaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12192">
        <property type="entry name" value="CATION TRANSPORT PROTEIN CHAC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12192:SF2">
        <property type="entry name" value="GLUTATHIONE-SPECIFIC GAMMA-GLUTAMYLCYCLOTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04752">
        <property type="entry name" value="ChaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF10611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="220" mass="24928" checksum="59EE65309E84BF01" modified="2013-06-26" version="1">MTEQAEPQDLWLFGYGSLIWKPPPHYDLRLPGYIEGYVRRFWQNSEDHRGTPEAPGRVVTLIDRQLWSTLTDEHPSAPPRVWGAAYRIPAAKVPEVTEYMNIREINGYSMQYTPFQRPEDMSATYQDVHVPTSTTTVDGKGAIKCLVYIGLPDNPQFLGPQDPQALAEHIVKSRGPSGENKDYLYELEAALNNLSPESEDEHISDLAKRCRAVEAREQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>N1QE94</accession>
    <name>N1QE94_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_165992</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757358.1">
        <property type="nucleotide sequence ID" value="XM_016908196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QE94"/>
    <dbReference type="STRING" id="692275.N1QE94"/>
    <dbReference type="GeneID" id="27905333"/>
    <dbReference type="eggNOG" id="KOG0475">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003181_2_2_1"/>
    <dbReference type="OMA" id="MFLKINM"/>
    <dbReference type="OrthoDB" id="44789at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04591">
        <property type="entry name" value="CBS_pair_voltage-gated_CLC_euk_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03684">
        <property type="entry name" value="ClC_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3080.10:FF:000011">
        <property type="entry name" value="Chloride channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1280.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF9">
        <property type="entry name" value="ANION_PROTON EXCHANGE TRANSPORTER GEF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7 9" id="KW-0868">Chloride</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="284"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="361"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="452"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="476"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="525"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="554"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="609"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="721"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="825"/>
            <end position="875"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF09237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="875" mass="96692" checksum="015DEF41E1AAB0BF" modified="2013-06-26" version="1">MHTRKGDSAGDFAGGSDGSVVVWHRGIYRRLSALSTAESGLHQQQDIASPEEVRVAEEIAEIKRYEDFTTIDWVQDAAREHQRRKTRRLSRAAHTRSGQRLGWRHKVWEAYDAAQGWIVVTLIGTAIGLNAAFLNIATEWLSDTKRGYCTTAFYLNEQFCCWGAEEGCPEFVHWSNWKGVNYVIYIFFSTFFAFTSARLVKSFAPYAAGSGISEIKCIIAGFVMKGFLGFWTLLIKSIALPLAIASGLSVGKEGPSVHYAVCTGNVISRMFDKYRRNAAKTREILSACAAAGVAVAFGSPIGGVLFSLEEMSNYFPLKTMWRSYFCALVATAVLAAINPFRTGQLVMFTVRYDRTWHFFEIPFYIIIGIFGGCYGAFVMKWNLRAQAFRKRYLTKFPILEATILAAGTAIICYWNMFLKIDMTESMEILFLECEGSHDYDGLCEKQNRWRMIFSLLFATVLRTFLVIISYGCKVPAGIFVPSMAIGASFGRMLGIMVEALHESFPDAALFSACEPDVPCITPGTYAFLGAGAALSGIMHLTVSVVVIMFELTGALTYILPTMIVVGITKAVSERFGKGGIADRMIWFNGFPFLDNKEDHTFGVPVSQSMTADPTVLPATGLTIRKVEQILAEAKFQGFPIVEDVRTRLTLGYIGRTELRYAIDRAKRDQPIAATAKCFFAPSEGPRTATTPSASAPAVSFHDAPGGAAGGSVMSVDFSKFVDPTPLAVHPRLPLETVMELFKKLGPRVILVEHRGRLTGLVTVKDCLKFQFQHEQHENPRDDSSQLRNQEQIWLILQYAAMWAGGKLSWLGEQVGLRKRLRLDSGGRYSELGGSPTQAENHTRESRHQSASGLDPEGAGPAAGGVELEDRRNVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1QEX8</accession>
    <name>N1QEX8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_128221</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757708.1">
        <property type="nucleotide sequence ID" value="XM_016902201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QEX8"/>
    <dbReference type="STRING" id="692275.N1QEX8"/>
    <dbReference type="GeneID" id="27899338"/>
    <dbReference type="eggNOG" id="ENOG502RP4Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019366_3_0_1"/>
    <dbReference type="OMA" id="YACSKVY"/>
    <dbReference type="OrthoDB" id="3226064at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="10"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF09587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="526" mass="60020" checksum="CEB8E4A6DF9971DB" modified="2013-06-26" version="1">MTSMSSFLELSHELLHCIFTEIEPGDLSSLSQTCRALHRYISGNRLLHKDLYVRRYDEPIDHPAEPDYEEWMHRRVKLEKLLGTDNRDAKRQNLEFVAGEIVSLVATADKDQEASKNIHLLGESFKSADNIDTLLCSSALFAPGRAGDNDQTQADTPELRQASAKLHCLYGVPVEPSVSRIPFHSFLRHPRAGLALSPSLCTRSHTHGRNTHQYARSKVYDLREYSDATLWGPFMKDGSHRVDWEKVEAIMIVLGFNLRRFTDRSDGRFPLVWKHPFVGATPGSYRTPPRIAPSEKKEFDEDAGVIRELALNLDALDPYGVTGSWMRVVCFLDYNDLYAFNFSDRIPEDQLREPIDTEEAIRLIRIKLQVTRIDAPNESGRRSSGSTAAFDEDDYDDDNYETEDEEEAEEDWSRFQGERLPVVHFRGTSRSLHASWDPNANSRIRGTVRQTPEGEIRWTTFSIFHGEERWRSEGIQVGGLKSGRGVLGNWFDKDYDMHGPAGPTAFWKESDELDDEKSEGTPVAYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>N1QF41</accession>
    <name>N1QF41_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerase I subunit RPA12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SEPMUDRAFT_16755</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757828.1">
        <property type="nucleotide sequence ID" value="XM_016908284.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QF41"/>
    <dbReference type="SMR" id="N1QF41"/>
    <dbReference type="STRING" id="692275.N1QF41"/>
    <dbReference type="GeneID" id="27905421"/>
    <dbReference type="eggNOG" id="KOG2907">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093932_1_1_1"/>
    <dbReference type="OMA" id="INLPCER"/>
    <dbReference type="OrthoDB" id="421002at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055029">
        <property type="term" value="C:nuclear DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006363">
        <property type="term" value="P:termination of RNA polymerase I transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10507">
        <property type="entry name" value="Zn-ribbon_RPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019761">
        <property type="entry name" value="DNA-dir_RNA_pol-M_15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034004">
        <property type="entry name" value="Zn_ribbon_RPA12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF14">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02150">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01030">
        <property type="entry name" value="RNA_POL_M_15KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00466">
        <property type="entry name" value="ZF_TFIIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4 9 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="13">
        <location>
            <begin position="75"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="10">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="6"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMF09707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="118" mass="13087" checksum="2FA434C91442CA5A" modified="2013-06-26" version="1" fragment="single">GALVFCTDCGNLLHSNTGRKEYIACDVCGMQNKDTSSKVVITHSKPSAFPSALRTRLRSDVQEVSESDMQDAATINLPCERCGHPEVKFYSRQLRSADEGSTIFYTCPKCAYKWNANN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1QF84</accession>
    <name>N1QF84_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Berberine-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_156828</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760044.1">
        <property type="nucleotide sequence ID" value="XM_016907697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QF84"/>
    <dbReference type="STRING" id="692275.N1QF84"/>
    <dbReference type="GeneID" id="27904834"/>
    <dbReference type="eggNOG" id="ENOG502QVGN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018354_10_1_1"/>
    <dbReference type="OMA" id="NLVINMA"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110269" evidence="6">
        <location>
            <begin position="21"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="65"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF11923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="510" mass="55430" checksum="E0120A10C23705CF" modified="2013-06-26" version="1">MASSIPLLLRLLFFGILASANLVEYQKRQGNDSSVQQCLQSADVPFSLPSNSSWSLDSEAWNARVAPVPSVVVFPQNEDQVSSAIKCAGESGVKVTTIGGNRSFQSMAFGRTDGALVVNLSNMKVLKYDDKAQTLTYGGPVTISEAAKFLWEKHSRALMHGRCPDVGMTGVAFGGGFGTLSRLHGTVLDDIVSVRVALADGKIVDASATENSELLWAVRGAAASFGVVLTVTIETFAKPSDTIVSYTIGFSEEVKNITMEENVGALTGLQAWAQSADNVDTISVRMDLKTNVSMKGFFYGSTSEFDTVTAGMLKHLPARMSLLEQQPYTDFLLSENFTTPGLIEGSNTERRYFYITSTVIPDSHPLTNETATSLFENTAYAPAPSAGRASGFVDLWGGAFTKTVAPDASAWKHDNNLLLVRWDLRALTLDKPFTKDDQANLRKGFYDFINAYKDDGGVPQGFPNYRDADWTVEETAEYLFGSNWDRLIKAKKTLDPQGVFNADPQDVPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1QF93</accession>
    <name>N1QF93_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cora-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_149772</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760064.1">
        <property type="nucleotide sequence ID" value="XM_016905760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QF93"/>
    <dbReference type="STRING" id="692275.N1QF93"/>
    <dbReference type="GeneID" id="27902897"/>
    <dbReference type="eggNOG" id="ENOG502QPTQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007127_6_1_1"/>
    <dbReference type="OMA" id="CNENYQV"/>
    <dbReference type="OrthoDB" id="29879at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010961">
        <property type="term" value="P:intracellular magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12829">
        <property type="entry name" value="Alr1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000027">
        <property type="entry name" value="CorA family metal ion transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044089">
        <property type="entry name" value="Alr1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535">
        <property type="entry name" value="MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535:SF55">
        <property type="entry name" value="MAGNESIUM TRANSPORTER ALR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="614"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="647"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="79"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="270"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF11943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="674" mass="75308" checksum="2713651A30F5BD2F" modified="2013-06-26" version="1">MNYPRSERSQTRYSTPEPDLDDHRNQPESLPPAPATESYFQARRGTLASIVDNERPPIPRVVVPIEAHGSIARDFENAIVDDDKSTKSNVTKKSANGRSPDEDWHRERRMHHERRGTASPVPARRAMFRRPNNEGDANSIRSHASDGSTSPPNSVDAFAPPLRRGRAGTMNSRAPSTAASLHRTVSNATHPRRRPTFGEEDAPGRLKSDVASHRSSAIEDVCFPPEDPPNTYTIDFEDLEEFVAETHTKTPVAHPFLPQFAKTASSKRVFGDQRSGSQPTHFFGLGNGAADDNEKTEEERGTSSEEETGDGGLHRTASTIDLPLNRWTFFSSEIDETIHAPELGGLLMPGETFRDIFELGPEGGVWWLDMLNPSEEEIFAICSAFRVHPLTREDITTQETREKVELFKTYYFLCFRSCYMVDPKHEDYLEPINIYAVVFREGLLTFSFCPNNHAATVRKRIGRLRDYVNLSADWICYALIDEIVDSFAPVLRELEQETDTIEDSVFTARFEDSRAMLQGIGECRKRIMALARLLGGKADVIKSFAKKCNESYAVAPRGDVGLYLSDVQDHIVTMMSNLGHFEKMLSRSHTNHLTQITLQHTEQGSRANELLGKITVLASILVPMNLVAGLFGMNVTVPGSADSHPGLGWWFGIVGVVFGLAITCLVLAKRFKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFE4</accession>
    <name>N1QFE4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin-activating enzyme E1-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SEPMUDRAFT_151307</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SO2202</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1 8">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757309.1">
        <property type="nucleotide sequence ID" value="XM_016906735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QFE4"/>
    <dbReference type="STRING" id="692275.N1QFE4"/>
    <dbReference type="GeneID" id="27903872"/>
    <dbReference type="eggNOG" id="KOG2013">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013325_7_3_1"/>
    <dbReference type="OMA" id="TPSEHIH"/>
    <dbReference type="OrthoDB" id="10255449at2759"/>
    <dbReference type="UniPathway" id="UPA00886"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.80:FF:000002">
        <property type="entry name" value="SUMO-activating enzyme subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.520">
        <property type="entry name" value="Ubiquitin activating enzymes (Uba3). Chain: B, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.80">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.20">
        <property type="entry name" value="Ubiquitin-like 2 activating enzyme e1b. Chain: B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
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        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028077">
        <property type="entry name" value="UAE_UbL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042449">
        <property type="entry name" value="Ub-E1_IAD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023318">
        <property type="entry name" value="Ub_act_enz_dom_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030661">
        <property type="entry name" value="Uba2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019572">
        <property type="entry name" value="UBA_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033127">
        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF5">
        <property type="entry name" value="SUMO-ACTIVATING ENZYME SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14732">
        <property type="entry name" value="UAE_UbL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10585">
        <property type="entry name" value="UBA_E1_SCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039133">
        <property type="entry name" value="SUMO_E1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00865">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="11">
        <location>
            <begin position="9"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="11">
        <location>
            <begin position="101"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-activating enzyme SCCH" evidence="12">
        <location>
            <begin position="306"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin/SUMO-activating enzyme ubiquitin-like" evidence="13">
        <location>
            <begin position="537"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="60"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="451"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="628"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="455"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="465"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="685"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="9">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR039133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF14732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMF09188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="696" mass="76130" checksum="F29175C3774682EB" modified="2013-06-26" version="1">MRDGGIAQSLGAPLTRKVKESRVLLVGAGGIGCEVLKNLVCCGFGSAGSASTVPQVQNLSLHQKQDAAQTTQEQQQEPQRQEHQHPQQQQQPEASSGKRAEIVVIDLDTIDLSNLNRQFLFRKNHIKKPKALVAKETASAFNPHINIDAHHASIFDSQYHVEFFEGFDLVFNALDNLAARRHVNRMCLAANVPLIESGTTGFNGQVQAIKKGVTECYDCNEKPVQKSFPICTIRSTPSQPIHCIVWAKSYLLPELFGTSEEESSDVAVTGEDNAEEVAKLKEEAEALKKIRGLMGKEDFAKEVFNKVYGADIDRLRSMSEMWQSRTPPTPLRFEGVCIDKDPEKHGAELAAQDQKVWSLLDNLKVFCYSIRQLSNRIAAGESGIEFDKDDKDTLDFVAAAANLRSHIFSIPSNSEWDIKQMAGNIIPAIATSNALTASLCLLEAFKVLRSQMPSQHPPPNPPHPQATTATTTTTATPAKLNGRHAAPLLGGSKMIFLTSKSTDRMITTESLRAPRNDCPVCSPVYAKISIKEGSSPTMQTLVDLLKRSLGYDDMSMVFNQQLIYDPDLEENLEKALTEFGIDGESISFLTVQDEADDAKVDLILSIRKSSTLEGEEDIRLSPSSLALPLKPAKPIMPDPSADATPGASVKGAELSNGKRKREAEDDVDAANKKAKARPNDGEVYVVDDEDGAILLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFT4</accession>
    <name>N1QFT4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_151421</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016906811.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="27903948"/>
    <dbReference type="eggNOG" id="ENOG502SMXQ">
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    </dbReference>
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    <dbReference type="OMA" id="GPMFADD"/>
    <dbReference type="OrthoDB" id="5343688at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="220"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF09383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="389" mass="42700" checksum="BF0718746A58BE19" modified="2013-06-26" version="1">MMGRYPKGFLDLQLANNAGYSTTTTTTWQPPSHLYSTATTDYISPLKLAPREEITRVSLISLQHQRYQEQHTKALVNRSTIPGFKTSAAFFASLRTNLRLHASPPPSPLSTPNSMRGSTPTLPPPSPLSGPVLTADMDAPDTPLPQDNPLADVPELTSYLATDDFEKMEALKLVADSVAQQRQTANRALIYHPVNMSVMTAVLACAGRYLAYRGFDYMGIILTCMGIFMSFMAACRYLTQGYLNAAEDINLAWLGDADILVTKFGDEVIGTVMIDWISGESRTKKKKAWRGLIKAWTVRLKYRHKGVGRALLEDAVSAAKKKGAESLDFAENHANSRRILSKFYNTTFDRDEAQSIEQLQNLMMTSPRKGSGGGGGFGGGGSSRRKSTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFV4</accession>
    <name>N1QFV4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_46825</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760263.1">
        <property type="nucleotide sequence ID" value="XM_016909015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QFV4"/>
    <dbReference type="STRING" id="692275.N1QFV4"/>
    <dbReference type="GeneID" id="27906152"/>
    <dbReference type="eggNOG" id="ENOG502SSTH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019845_6_2_1"/>
    <dbReference type="OMA" id="CAHHFLD"/>
    <dbReference type="OrthoDB" id="202203at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF3">
        <property type="entry name" value="FERROPTOSIS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="6">
        <location>
            <begin position="45"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF12142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="503" mass="55711" checksum="38F1C597B507D491" modified="2013-06-26" version="1">MPNYGLPSHKEPRHLPGHHRDATALTLSDNYKSKEPVGIGVEPLNIIILGTSFAGLSCAHHFLDHTIDRLCTTTQASYRLIVIGPSTHLYWNIAAPRALVPSGLVQHEDPFIAVEPGFHRHRGHQFTIIQGSCIAMDPTERSIKMPIKNLADLTKVQTLNYHALIICTGTSTHSDLLSLHGPHLDTAEALHRFHGQLERATSIVISGGNCSAVEVAGTLATYLNYKRHLPFRTKRKPPKQITLISGGSVLLPDLAPPLQKKAEKQLLDLGISILHNHIRVIKTETLFQHHDDPIKDNPPSSPSPPSTTTTTTNLLLSNGTNILADVYIPCTGVVPNTQFAPSHLHDPRGYLLTHNKSLRVERAGPRTFAVGDVASYSQNYLGDVYPAVGVVMHNLEMDLLRFEFLALASANDENEKEEDDEDNDYTEQVEHLQDQEYVQRIKEDCIVCPVTRFGGVGSWMGTRLPSWVVYLFKGRRYRMGEKGVAKVVVQGKGPYTYGSWKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-12-14" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFX9</accession>
    <name>N1QFX9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_109005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760349.1">
        <property type="nucleotide sequence ID" value="XM_016900760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QFX9"/>
    <dbReference type="GeneID" id="27897897"/>
    <dbReference type="HOGENOM" id="CLU_2098363_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF12228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="116" mass="12933" checksum="7EF8A9CBBA9F0C15" modified="2013-06-26" version="1">MLMSTHANWPMNGRPSRVIECTSYNRLRSQGRWLTKWSRRLNTSNMKMPSSGVRTGCGNEELAATILNIHKTDLPGHVYKCVRGAGQATSAETQVIILAAYLSSVVAEKTLTVQYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFY3</accession>
    <name>N1QFY3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_46779</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760354.1">
        <property type="nucleotide sequence ID" value="XM_016909012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QFY3"/>
    <dbReference type="GeneID" id="27906149"/>
    <dbReference type="eggNOG" id="ENOG502SD76">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047846_0_1_1"/>
    <dbReference type="OMA" id="ENVPIYN"/>
    <dbReference type="OrthoDB" id="5405126at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF12233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="375" mass="42726" checksum="113076C041E3ACA7" modified="2013-06-26" version="1">MASLCTRCSLRLQRQSQPSRLITRTFCQSTTRPVEFPTFTPSTNKTLNDTLAAYRDKHLVPAFLTRREQQLIFSPHKKDYLKENPTTIELGGQEIKLQWFDRHTERPARMKLVKAALEQIFQSKDGRDWENVAKLLQALKEVHKAPLEEKVQDKIVRKAVRQGQISQVLKMLQHADKTSMSLKSGLVLKTLVMGVRDTAQRSGWEKEHVIRALEMLQRIAQLLETEQHGAGRNIVEGDPRMDPFILGVQLELVSVYAYKHNQGVDENETVARYADRLLCSIGEEQLDASVLETKLVLREQGPHSEFQHAVPILHGVFLANKMLGEEMPQAEEARRLIAAYEHTLSGLAAILEGRAPAQGSYDHSALEAWRRMIRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1QG01</accession>
    <name>N1QG01_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_149961</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760374.1">
        <property type="nucleotide sequence ID" value="XM_016905878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QG01"/>
    <dbReference type="STRING" id="692275.N1QG01"/>
    <dbReference type="GeneID" id="27903015"/>
    <dbReference type="eggNOG" id="KOG1212">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_9_2_1"/>
    <dbReference type="OMA" id="EPWRPEM"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF11">
        <property type="entry name" value="AMIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="7">
        <location>
            <begin position="78"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="230"/>
            <end position="233"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF12253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="546" mass="59782" checksum="ADDE7D463498D6EC" modified="2013-06-26" version="1">MSQSKWEQISAKARQKVLDDIPAEWKIPQEKLPGDDIRDVTGVAASSGILSERELAITDSLATEIVAKVGTGEWKAEEVTVAFCKRAALAHQVTNCLTVIMFSDAIKRAQELDLEFHRTGKPIGPLHGLPISLKDNFNITGYPSSVGFCHWASDPMPQDSTIVSTLLSLGAILYVKTNVPTAMMIAETVNNCYDRTLNPRNRATTSGGSSGGESALIAFGGSPLGIGTDIGGSLRIPAACTGIFTLKPSFGRFPHFDARSALAGQEAVASIHGPMARSIADLKLYAQSVIGTEPWTRDPKCLEIPWRGAQEKAVVEVKQNERKKKPKIAVLWDNGMVRPTPPVTRALRETVTKLQAKGYEMIEWTAEDHAEAIDLLSKFFLADGGISCEKILDPVGEPWRPEMKAYEDAKVATGYEIWQWQKQRTALCKRYLDRWAAVDGLDAILGPTTPYASPKNGEFRHVGYTGVFNILDYSAVSFPTGIYVDKEKDVVDLSVQAYGDVDAQTQSEYDAEVSHGLPISLQLTGKRLQEEKILALTEMLLEDLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGC4</accession>
    <name>N1QGC4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_46784</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760478.1">
        <property type="nucleotide sequence ID" value="XM_016909013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGC4"/>
    <dbReference type="STRING" id="692275.N1QGC4"/>
    <dbReference type="GeneID" id="27906150"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_16_1_1"/>
    <dbReference type="OMA" id="CHEAIGR"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF1">
        <property type="entry name" value="TRANS-ENOYL REDUCTASE STHE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="17"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF12357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="367" mass="39813" checksum="A6B0B2F217C42433" modified="2013-06-26" version="1">MANEPSIPAHQAAVKQDASGKIQLEHHAPVPELQPDTVLVKVAAVALNPYDYKLPLHFPSPGTTGGSDFAGTVVKIGSQAAIDRPDISIGDLVSGCVYGWHPDTPENGAFANYVRADARLVFRIGAFKIEEAATFNAAFATLCLALWHSDALDLTHSPTVPISGSSLEKPEYVLVYGGSTASGTMALQLLKLSGYSTIATCSPKNFDLVKSYGADHVFDYSHPDTPSQIKTLTRGTLKRVLDCISDHHAITVCHEAIGRLGGRLVNLELAPDPRPGDKRRRIVKHYFVDGKCSRKLLACPPGYRREPSRAKHEFAVEKAVEFQRLMDERSLRPHPIQIVEGGLEGIVKGLEMLKIGVSGKKLVLRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGF0</accession>
    <name>N1QGF0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase</fullName>
            <ecNumber evidence="1">2.5.1.114</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_111062</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36355"/>
            <dbReference type="Rhea" id="RHEA-COMP:10164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10378"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64315"/>
            <dbReference type="ChEBI" id="CHEBI:73550"/>
            <dbReference type="EC" id="2.5.1.114"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.5.1.114" evidence="1"/>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757729.1">
        <property type="nucleotide sequence ID" value="XM_016900895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGF0"/>
    <dbReference type="STRING" id="692275.N1QGF0"/>
    <dbReference type="GeneID" id="27898032"/>
    <dbReference type="eggNOG" id="KOG1227">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023588_0_0_1"/>
    <dbReference type="OrthoDB" id="2387925at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102522">
        <property type="term" value="F:tRNA 4-demethylwyosine alpha-amino-alpha-carboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031591">
        <property type="term" value="P:wybutosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030382">
        <property type="entry name" value="MeTrfase_TRM5/TYW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026274">
        <property type="entry name" value="tRNA_wybutosine_synth_prot_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245">
        <property type="entry name" value="TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245:SF25">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038972">
        <property type="entry name" value="Trm12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51684">
        <property type="entry name" value="SAM_MT_TRM5_TYW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase TRM5/TYW2-type" evidence="4">
        <location>
            <begin position="112"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="88"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="503"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00049400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF09608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="525" mass="59993" checksum="6F968D815C47FFE2" modified="2013-06-26" version="1">MDRAVEAWRLQHGIEKEIIAPLSKKLCKSYTVYGCMLLLPQNALEGPEWSPLEPLIHHNNINNNNTALNDLYKSIAKELKITHIASNKPIPLHHPHPHHPHPPPHPPPANVTDTCNDNNNNNETTPTSSENILRAPINFTPLYGDFGPETCSQPHPTQEDFDKAFWVTAKQNGIYQVWAPRWTMFSRGNISEKARLLTLGSVREAVEDAAVRGGREGGEEEEEEERELQPPGFAAIDLYAGIGYFAFSYLRAGADQVWCWDINPWSIEGLLRGAKANKWEAVLLSHGMDHFDGDLLQETATTSMSKETLKKGIRKAKLLIFNESNIHAPERLQQYLFPPPPPLPQPHHHPPQITIRHINLGLLPSSRESLSLAAQILSLQHQQQQITSTRQKEDKSKRRRRKGSTSWIHMHENFLLEEILAKANERSKELEEKIHGFLSIIHYQKNITWKERNEMEGEEKRKKEREKRTSRVRVKIEGINRLKSYAPGVMHCVVDFGVEFLEEEGEEREEGQEEEEGGEGEDGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1QIS3</accession>
    <name>N1QIS3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NADPH dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_149627</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759841.1">
        <property type="nucleotide sequence ID" value="XM_016905674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QIS3"/>
    <dbReference type="STRING" id="692275.N1QIS3"/>
    <dbReference type="GeneID" id="27902811"/>
    <dbReference type="eggNOG" id="KOG0134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012153_6_2_1"/>
    <dbReference type="OMA" id="NAMIFKE"/>
    <dbReference type="OrthoDB" id="1663137at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051799">
        <property type="entry name" value="NADH_flavin_oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43656">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43656:SF2">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="5">
        <location>
            <begin position="25"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF11720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="481" mass="53204" checksum="967D58BBCD2C0F18" modified="2013-06-26" version="1">MGDLGSMENDKAYEHKLSPLETIAQPLTLPCGLKLPNRLVKCPMQETLAEAPYFDPPIDKFRKIYKKWAESQYGLIITGQVQVDLRFLSIAGDVCTRPESTSGEILAKWKEWAQIAQEYGTPCIVQLAHPGRMSPAGAGNRPHDMPALCPSSVPVKMGDTWLDKLALDKLLGTPKEMSLEDIDEAVENFIRGAVVARDAGFAGCQLHGAHGFLLSQFLSPHTNRRTDDYGGTPEKRLTLLKRIVGEVRARCPPPFCLSVKLNSGDYMGEEGLQQEEALEQVRWLVTCGMIDFVEISGGNAEQKTSGLHNSFDKKTIDKAPQIKESTRIREAYFTEFAEKVQKMESPVPIQLSGGFRSRTGMADAIDSGICELIGLGRSAVLEPELPRKTLLNPAFSDEEAMGMSHIVRGQWLARMIPAKVVGSGLPIQFFYYNMRRLGSGLASDPYASLPWVMFTNIYEAITGSLWSTLHGFLQGKTTYKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1QIV4</accession>
    <name>N1QIV4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase family 12 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_45541</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 12 (cellulase H) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760470.1">
        <property type="nucleotide sequence ID" value="XM_016908972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QIV4"/>
    <dbReference type="STRING" id="692275.N1QIV4"/>
    <dbReference type="GeneID" id="27906109"/>
    <dbReference type="HOGENOM" id="CLU_1012542_0_0_1"/>
    <dbReference type="OrthoDB" id="89349at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002594">
        <property type="entry name" value="GH12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002">
        <property type="entry name" value="BLR1656 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002:SF9">
        <property type="entry name" value="XYLOGLUCAN-SPECIFIC ENDO-BETA-1,4-GLUCANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01670">
        <property type="entry name" value="Glyco_hydro_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF12349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="275" mass="29676" checksum="64ADFEFDD5C0A3FC" modified="2013-06-26" version="1">MPQSEKDSKSDDAKTNNLKTDDSTSANSNTDDSKALRGGATDCGNNNIGSGKWQLYNNPWGAAYGNGRSCTSVSYVNGNDIGFSTAWTWDRGTGQVKSYPNAKQFHNNVSIRNLRSLATSVDWNLGCNERTPGASIVYDIFLNSGGRRVEVMVWLGAPSAHPIAGSYNGGKPVPTLSGVRVRGDGYTYDLFIGPGPGVDVYSFVISGTLQENGGRWTKQYSSNLANILKFLTTDRRLGRKRLSVQTTLESSQFGIETTVGTNCKFTVNKLSIAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJ10</accession>
    <name>N1QJ10_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leo1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_146305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765327.1">
        <property type="nucleotide sequence ID" value="XM_016903565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJ10"/>
    <dbReference type="STRING" id="692275.N1QJ10"/>
    <dbReference type="GeneID" id="27900702"/>
    <dbReference type="eggNOG" id="ENOG502S4N0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030892_0_0_1"/>
    <dbReference type="OMA" id="TNIYRWS"/>
    <dbReference type="OrthoDB" id="20844at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990269">
        <property type="term" value="F:RNA polymerase II C-terminal domain phosphoserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007149">
        <property type="entry name" value="Leo1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23146">
        <property type="entry name" value="LEO1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23146:SF0">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN LEO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04004">
        <property type="entry name" value="Leo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF17206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="515" mass="57413" checksum="E7971182FAB82D33" modified="2013-06-26" version="1">MSEGRESHEKEVTNEDSAAGMDATTNDMTGIGGEQSNGAQTSRTGASEDGREDSGDDLFGDEGDENDAASAVDRAPRQLDDAELDSGDDEGREDRAQHRGDDEEQHQQQFEDHEILSMDVEVARQPVPEPSDGEMYLLKVPAFMSIEAEPWQVTTFQPPKTDHHSRKPASATFSAFNTAMTTMRWRHSPSDHSLLQSNARINRWSDGTLTVQLASDPHIQYEVDGNPLAPPQRNPKIPTPISATGRKPGGRAGQSMDERYDQKNDAFTYLVAPVEAAEALRVTHKITAGLSIQQPDNAEDDAIERLQAALALAANATKVAGASGHLEVTEVDPEEQRRLAEQAERQAMRDKRKRENAQERERLRTDRALGRAGISSGRYGGLNVGMLEDDEMEGGRGRPQAGKPRPKPRRRRNSEYSDDEDYGNKRFTNREDDYDQEDDFVARSDEEELVEDDDDPDDGIIEEPRERTPKRDRPRSAPGDNGRIGDDEDAEGEIDEDIPQVRSKRRRVVDDEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJA6</accession>
    <name>N1QJA6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_149733</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760001.1">
        <property type="nucleotide sequence ID" value="XM_016905737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJA6"/>
    <dbReference type="STRING" id="692275.N1QJA6"/>
    <dbReference type="GeneID" id="27902874"/>
    <dbReference type="eggNOG" id="ENOG502QTSJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019363_1_0_1"/>
    <dbReference type="OMA" id="CWPYVSM"/>
    <dbReference type="OrthoDB" id="2890403at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109619" evidence="1">
        <location>
            <begin position="19"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF11880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="483" mass="51299" checksum="635D56A8E87FA651" modified="2013-06-26" version="1">MTLRVASFFTSAVALAAAADPSLSLKTYIDALKLNGSFTPFMESYWTGLPHHRRTPFAVSPDGKTGYLAYLGSNGNGVYVQHVDLSTFNATGTTVTIANVKEAGGLVGHNDGFAMLGNEPLPASTDDAPPNDTPVPAIYKYTNGSQEFKTFVAGPGVHEADGLSMSPDMNGDLVWSDKAELYGAYFVVTAYTGDATGHFGDSIQYVNSNGTLEVIDGASSSWGCSHNTGIAFEAADEAPFASICAEDQGAIWLNTKGQGMSTDGLKISNENTTNGGGGEAMGGMSGSYSALAQFVNSTSYIFAWVSRGAVNLKANEWMGEGYTNALNRTNGRRVAIALFSDKETMVSEEASSEVGAASGDDQVNWVTPEIGADRSNAHVAAFDSDYALVSWEQIDEPQCDFIAMGCKGKFSGSYFQLVNSAGKMIGEPIKDMNTYVAGDMVTMNDGRICWPYVRMSWELDVPVVESQMMANATSMSFACMSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJG4</accession>
    <name>N1QJG4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_149775</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the avfA family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760071.1">
        <property type="nucleotide sequence ID" value="XM_016905761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJG4"/>
    <dbReference type="STRING" id="692275.N1QJG4"/>
    <dbReference type="GeneID" id="27902898"/>
    <dbReference type="eggNOG" id="ENOG502RVMP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090039_0_0_1"/>
    <dbReference type="OrthoDB" id="10254221at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051606">
        <property type="entry name" value="Polyketide_Oxido-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355:SF2">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="2">
        <location>
            <begin position="8"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF11950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="265" mass="29417" checksum="58E5DE4E60378C49" modified="2013-06-26" version="1">MVKYTLCGATGGTGRSILRCLLANPPQDLELNIFLRNKKKLLGQFPDLETNPSFALKIFEGQNTDHELWKQALSGTDVIFMCIATNESKKGMSLFSDTAEAVTKALQELQSEQQQSYKTPSILILRAIPLNEKFNPGTNSPAFLFFALRYLYDAMVDANKIYETRVKEYPGLLDIIYVDPPAIHDENGTTCTGYRLDVEPYNEQDSAAGHNLSYADLGAAYCEIALRRKEFRGQGVAVTATGPVKTTWGSNMYFLAGGILGRFWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJT9</accession>
    <name>N1QJT9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Meiotically up-regulated gene 154 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_90249</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758930.1">
        <property type="nucleotide sequence ID" value="XM_016910526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJT9"/>
    <dbReference type="STRING" id="692275.N1QJT9"/>
    <dbReference type="GeneID" id="27907663"/>
    <dbReference type="eggNOG" id="ENOG502S81A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044030_1_0_1"/>
    <dbReference type="OMA" id="WEVAVWD"/>
    <dbReference type="OrthoDB" id="3363151at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043007">
        <property type="term" value="P:maintenance of rDNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007096">
        <property type="term" value="P:regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018819">
        <property type="entry name" value="Nur1/Mug154"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28293">
        <property type="entry name" value="NUCLEAR RIM PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28293:SF1">
        <property type="entry name" value="NUCLEAR RIM PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10332">
        <property type="entry name" value="DUF2418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="298"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="333"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="410"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="430"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF10809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="440" mass="49445" checksum="40770EEA3314A497" modified="2013-06-26" version="1">MPPLVRRRPLIERLKAWLDPLDLLLWLAEELNDDAYEHWLQLWSTPIGLALNIVFILATGASRRARGRGSDDVFGDEYRSGTGWFAWLASFLVYVLVLLSISNALFTFWRRRSYRLFEQSVDVPPPTPSAHRVKVDSSPMSSSPLRYMQAVLTSATASSRAYPDPEREVWELNLWDPKPFNLNIFTLFSPGHIVIYSLLLPPTASDPRPSVTVFTAMAFSALLSAQLWMLKASFSQQAKDSALIHGEVMNEYDTKYVHPNLIRPMRDVGIQTRVAGNTSRTNHTREIDVYTPTTIIKRGFRTHPNPNYAREYDPYGLASRPEDSKRNPGFPDTPTNGYVNRTTQSYSRPSTALTDFSSPLKPHHERLRERSPIKGDGGSMGVYSHAASPLRKAASSNHLKPLAGDLRRTTLGSPLNRRSASGPGGADPLDLARRRDTGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2024-11-27" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJW1</accession>
    <name>N1QJW1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dienelactone hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_56041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764688.1">
        <property type="nucleotide sequence ID" value="XM_016909387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJW1"/>
    <dbReference type="STRING" id="692275.N1QJW1"/>
    <dbReference type="GeneID" id="27906524"/>
    <dbReference type="eggNOG" id="KOG3043">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054590_0_0_1"/>
    <dbReference type="OMA" id="WGGKIAC"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47668:SF1">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47668">
        <property type="entry name" value="DIENELACTONE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G01940)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="73"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF16567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="249" mass="28031" checksum="F016542D6F58D688" modified="2013-06-26" version="1">MSQSRACCTVPPIVAEGYKEKGEWITNNRTYHDEDRFFGVARTSGICFYDIFGFFPQTLQGADILAYSDKERPYQVFMPDFFEGQPADISWLPADTKDKETKLGEFFSTKAAPPKTLEKIPKVLAEIKGQRSSISEWGVLGYCWGGKIVNLSSQAGTPFKAAASCHPAMVDEKDAPGITIPFAMLPSKDEPKEDVEKWQKGLKVKNIVEWFPSQVHGFMAARGDLNDKAVEADYKKAYELVLHFFHEHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJY4</accession>
    <name>N1QJY4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Splicing factor YJU2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_149882</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the spliceosome. Present in the activated B complex, the catalytically activated B* complex which catalyzes the branching, the catalytic step 1 C complex catalyzing the exon ligation, and the postcatalytic P complex containing the ligated exons (mRNA) and the excised lariat intron.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CWC16 family. YJU2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760241.1">
        <property type="nucleotide sequence ID" value="XM_016905830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJY4"/>
    <dbReference type="STRING" id="692275.N1QJY4"/>
    <dbReference type="GeneID" id="27902967"/>
    <dbReference type="eggNOG" id="KOG2989">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053603_1_0_1"/>
    <dbReference type="OMA" id="ENCDYQN"/>
    <dbReference type="OrthoDB" id="674963at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000349">
        <property type="term" value="P:generation of catalytic spliceosome for first transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03226">
        <property type="entry name" value="YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007590">
        <property type="entry name" value="Saf4/Yju2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043701">
        <property type="entry name" value="Yju2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111:SF1">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04502">
        <property type="entry name" value="Saf4_Yju2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="204"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="116"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="222"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF12120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="336" mass="37794" checksum="5EE0ACAC5B97F655" modified="2013-06-26" version="1">MSERKVLTKYYPPDFDPSKLERKRGPKQTGPKVQTVRLMAPFSMKCTSCGEFIYKGRKFNARKETTEEKYYAITIFRFYIRCTRCSAEITFKTDPKNMDYTCEKGAKRNFEVWREAKLAEETEEETLDRIAAEEENRDAMKELEKKTLDAKTEMAIADALDDVRHRNATRERVDKDGISTVVAPKVDEEAERIERELEEQAKMAFQSSTGERVRRLGEEAASEQSSSAASWRSADVDRAAMPPPALPTFQRTTKSKKDFGGTLGIKKGVLKKPAVTPPFPVLENVDGDKTEAAAPAAERDVLLDKTFNAHDIPEKHVQLGVGLSLVDYGSSDSDSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1QK73</accession>
    <name>N1QK73_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_126515</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760341.1">
        <property type="nucleotide sequence ID" value="XM_016902080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QK73"/>
    <dbReference type="STRING" id="692275.N1QK73"/>
    <dbReference type="GeneID" id="27899217"/>
    <dbReference type="eggNOG" id="KOG3548">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_491044_0_0_1"/>
    <dbReference type="OMA" id="HYHYPAT"/>
    <dbReference type="OrthoDB" id="129353at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17745">
        <property type="entry name" value="BRCT_p53bp1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047249">
        <property type="entry name" value="BRCT_p53bp1-like_rpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041297">
        <property type="entry name" value="Crb2_Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047252">
        <property type="entry name" value="TP53BP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15321:SF3">
        <property type="entry name" value="TP53-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15321">
        <property type="entry name" value="TUMOR SUPPRESSOR P53-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18115">
        <property type="entry name" value="Tudor_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="5">
        <location>
            <begin position="252"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="196"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="205"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF12220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="555" mass="60816" checksum="65BF8A813D47B32C" modified="2013-06-26" version="1">MAEEMPIVDATVMGDADETPVESAAQPDTTAKEVDDVDEPTPTEPVAHDRIFALFKGRLHYHYPATWLGSSLDGTKCKVRFDDQTVTNIETSQVRRLELRIGDTVKVDEKEKRKKNWVIVGFGPMATTDEERALGTDVFGHTHVKVQPKSGRESLSQSTSSTPAEASEVHTVLVNYLYLTTTMWPQYNLRTFEVPSKASAPRAETPSSTRTGTPSTTNTPRSRRAPVPIVKAKGTRTSHLRETSAASPRSASSEAMFAGMAFAISFLEADEEKQAVTKLIQRNGGIILEDGFEELFDLPDISGSSDPISPSKGSPRQKDVTRLVSKLQLNSKYKELRFAALIANVHTRRAKYMQALALGLPTISGRWIVHSLDESKNPSKDDTGPLPWGRYLLPAGHSTFLNAIRSRTLATYDAATASLEQIVESRARLLNDEGLVLVAPKTAADDWKRRKTYAFLTMACGAGTVKRVGDVQEAKKLTLDNAETWKWVYIDSSVADAEKVLFGKDTTTTAGKKRKRGSEATIAVGDEKMSATDGVVKIVNDEFVVQSLILGALVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1QL21</accession>
    <name>N1QL21_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF676-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_146855</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016766082.1">
        <property type="nucleotide sequence ID" value="XM_016903911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QL21"/>
    <dbReference type="GeneID" id="27901048"/>
    <dbReference type="eggNOG" id="KOG4372">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027968_1_1_1"/>
    <dbReference type="OMA" id="FCTPHVG"/>
    <dbReference type="OrthoDB" id="273452at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044294">
        <property type="entry name" value="Lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482:SF65">
        <property type="entry name" value="ESTERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12320)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482">
        <property type="entry name" value="LIPASE ROG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="DUF676" evidence="5">
        <location>
            <begin position="8"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="338"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF17961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="471" mass="52839" checksum="79A9055FF636AB4C" modified="2013-06-26" version="1">MASSSSPQADHLAVLIHGLWGQPKHLDFVRNALREEHAEDDLHILVATCIGDNKTYDGIEVGGERVANEIEEKLAQLEQDGHTIRKISIAGYSLGGLIARYAIGVLYSSGLFDRIQPVNFTTFATPHLGVRTPKRGARSYLFNVLGAKTLSTSGQQMFLVDTFRDTKRPLLSVMADPNSAFVKGLSMFKNKWIYANTMNDRSVPYYTAAMSRIDPFVDLDKITVHYLSPPGEVILDYSNPATPRRSPWEDMTTLEKIRAAPRQTMKTLPFYLVLLTLMPIAIPAFLLNAGYQTYRSAQRIRHHESGSAFNLDKYRVRLLEEAEAATDRAYENLANSTREEYLPTPASESASSSASTSSSSSSISNLKNSNTERRKGEEEGKEEADLRKLSRRESKREKCHDFPLLALTTEQFDMIDHLDRCVGFEKFPVHIQKVRHTHAAIVVRMQKPLSGAESFSEGVVVVKHWASKFEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>N1QL87</accession>
    <name>N1QL87_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_57060</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765168.1">
        <property type="nucleotide sequence ID" value="XM_016909422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QL87"/>
    <dbReference type="STRING" id="692275.N1QL87"/>
    <dbReference type="GeneID" id="27906559"/>
    <dbReference type="eggNOG" id="ENOG502QQWQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003258_0_0_1"/>
    <dbReference type="OMA" id="TLWKNNM"/>
    <dbReference type="OrthoDB" id="67716at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059141">
        <property type="entry name" value="Beta-prop_Nup120_160"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056548">
        <property type="entry name" value="HEAT_Nup120"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021717">
        <property type="entry name" value="Nucleoporin_Nup160"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048884">
        <property type="entry name" value="Nup120_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21286">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21286:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11715">
        <property type="entry name" value="Beta-prop_Nup120_160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23300">
        <property type="entry name" value="HEAT_Nup120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21486">
        <property type="entry name" value="NUP120_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup120/160 beta-propeller" evidence="4">
        <location>
            <begin position="80"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup120 helical" evidence="5">
        <location>
            <begin position="664"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin nup120-like HEAT repeat" evidence="6">
        <location>
            <begin position="873"/>
            <end position="1078"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF17047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1241" mass="139608" checksum="24C096988D70B1E8" modified="2013-06-26" version="1">MSSAVLHTPTLYQETRLSIAPTTPNSVLDIQISDRSLGRAGTGRKRAFEDISGIDEESYARKHLATEGSVFSRPKSRAPRTFLWRVLNDRHTLELQCIDLAQDRRHLGSECCSDSWLTFRISLSDAIIPRGVALADDEARDALDVFVITPKGLYTVTLRRDLLLRETVPVDFDPRSVYKHYPLGHRAYRITAVSSLFLLVSLENGDFIRLERGKDESGSQWRQLYVGEGGWSGLTGLKGIWSKTTVKHGELHLMPSAMIAMAMSPDDKHIWTVGIDHVLKAWDTNTGKAAIRMDLLEDSIGQEDRRKQAHIDPGQGTVLQVVDSMGVPGTAYFLVCYSPRDHQFRFFAITHREEKLILVDTQPPEAKLNAPIAEMLGTSLWNLEQFHVSPGPQWNGSQMWLRARSGGVCETFVVTFDLLGENGVSNDFSDAWKNDWTRVENSSLSIEALRRVPSFADLDPTSETTATSSEKWLKYLFYPGRFSEASLEAALAMYRKTGGVSTASRGINKMEEPLKGRLVSAVIAKTTVGRHDHEKPDYHRYQLELCEQWQIYFRLLSHLHALRLASIGFAYDDDDGLPWSVCADVVAPIRQSSEFELVAYNSELVQGRHSRVLNQEIQTRIWPNPDEDLLKSQILAVARQLRQCLSPSSQEKLLRAAIAEALDQSADKSALLGIQNIYDQCNIGEEISNEDFDAITEAATVFNGLGRLDDDSLLMVLEAMDTDLTLQGTDSGRALQRYGKDLTIAITQQTLQDTQAVLLDILALVLFMHGDLEPEELDENFHPCEMYDSIIFRLKTAELRLWLVEHMRLEPKKVGSTNEEPMAMTLYESLFIGDWRSLEGGQPRLLSQLVTAWSKSWALGIDPNENWTGFTDYVMANLVQHKEWDLALDFVRFLSETTPWATYLKGRVHMARGEFDMASLAFDDAADELSHIPDAASTLSHLVLSVEDMEYFGQGLARYFQHISGLYESVKAFSYTGEYANLAFRHLRTGGDVSQALHDLDELKREKGSALSIPQLISAAMEELYYLKAQIAHDSILGRLFSASHQINRFDEAYSALAQIMDPIVRRSNLRILISRCIKEDAVPDLLSLPIAEDLVQTVDAELLGLAKSSMGTSNTQLSGPPYHQILFAFRIQHSDFRGAASLLYTHLEYLKFTNPHAMKDPDDDTLIQVYVLLINTLVCCGEGEAWLLAEAIEGVHPAGTKRRLVRLEDVRREYAEELDRRSEVQMGRFAVSGGDHMEMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>N1QLH2</accession>
    <name>N1QLH2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_126425</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760207.1">
        <property type="nucleotide sequence ID" value="XM_016902067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QLH2"/>
    <dbReference type="STRING" id="692275.N1QLH2"/>
    <dbReference type="GeneID" id="27899204"/>
    <dbReference type="eggNOG" id="ENOG502RNPA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1836407_0_0_1"/>
    <dbReference type="OrthoDB" id="19261at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797:SF1">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05805)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="8">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF12086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="140" mass="15442" checksum="E15BBC110508A82C" modified="2013-06-26" version="1">MLLFQVSFSAHTVIGTVLFAFAWLQPFLGVAHHYILLSTNKRTLMSAMHILFGRILIILGMINGGLGLALAEQSTRAENIIYGTLVGIIWVAYTLVTLGYEVKRDNQAQWALKRAGSTDDSERSTSIKQVSGEVVKSEML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>N1QLY5</accession>
    <name>N1QLY5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_112875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764974.1">
        <property type="nucleotide sequence ID" value="XM_016901001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QLY5"/>
    <dbReference type="GeneID" id="27898138"/>
    <dbReference type="eggNOG" id="ENOG502RXN0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038105_0_0_1"/>
    <dbReference type="OMA" id="TIHQEKN"/>
    <dbReference type="OrthoDB" id="3946116at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009976">
        <property type="term" value="F:tocopherol cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025893">
        <property type="entry name" value="Tocopherol_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35309">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35309:SF4">
        <property type="entry name" value="TOCOPHEROL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF16853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="333" mass="37955" checksum="428664037125E741" modified="2013-06-26" version="1">MEHHRPHPGAAFEGYYSKFDLPSGAHVALILCEVRNARQKPNMLSFTYVPKDDPAGYYQREVFTEDMKQEPSLEDKGFRIDVPGIGHVRWFEDHTEYDIQHTDFTLKAKTTSRTPWGSNDTPEGLLVNLPLPLHWHVHSLASGCDYSMTISDYNLPAEDTSGQAIVHDEKNWATSFPSAHMWLQARDGDSSFCCAGGQILGMEAFLLGYRSKDMNLDFKPPFALRLAGLSPFLSYRESWDDRTFELTVQNFTQKLVVKASAPRQTFFSLTSPFPEGHRENYLGQSFNATFEVKIYESGWFSPWKLVREDTFSHASLEFGGGYYPHAGSKDRFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1QM69</accession>
    <name>N1QM69_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallo-dependent phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_146092</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765099.1">
        <property type="nucleotide sequence ID" value="XM_016903451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QM69"/>
    <dbReference type="STRING" id="692275.N1QM69"/>
    <dbReference type="GeneID" id="27900588"/>
    <dbReference type="eggNOG" id="KOG1432">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019692_4_1_1"/>
    <dbReference type="OMA" id="HVNDYCS"/>
    <dbReference type="OrthoDB" id="783096at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07383">
        <property type="entry name" value="MPP_Dcr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000054">
        <property type="entry name" value="DCR2p Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440:SF0">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="219"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF16978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="573" mass="63105" checksum="2202F87401D35CBC" modified="2013-06-26" version="1">MTRRIVRTLGQIAACISLFCVLIFFADSRYRVLPASIHHALPSHHAGTVITDVTIAFCSTVNPLSKCLLEDHNWKRVEKDLLLGGGWIRSAYLHVQRKQEEELLSDDKVVVGVKVGKQAPAIGGQDESQEPWESRPGGLWIQRSSKRHDSDSDRAVTAIDVLFGPDAVDPRPNWVLESTTLLIDGINANYAPRLSARHGRPRAEHEISPTLRVNKDGKFKILQISDAHLSTGTGACRDAIGIDNKPSTNCEADPRTLEFLEQVLDDEKPDLVVLSGDQVEGPAAPDTQTAIFKIVAPLIERSIPYAAIFGNHDDEGPRSSPRVAQMALMQTLPYSLSEPGPQKAEGVGNYYVEVLAPGSQHSALTLYMLDTHSLTPDEKRYKGYDWLKPGQIDWFRETAQGLRKAHARYSHIHMDMAFIHIPLPEYADRSNVMAGGAWKESVTAPGFNSKFYDALAEEGIVAVGCGHDHVNDYCALRPHKHEVAARDEVGEGQQPHHAHTREKLGPWLCYAGGSGFGGYAGYGGYHRRVRVWEVDTNAGRMSTWKRVECCGDEVGKRIDEVVLADGGNAIAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-12-14" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>N1QMA0</accession>
    <name>N1QMA0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_146133</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765144.1">
        <property type="nucleotide sequence ID" value="XM_016903470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QMA0"/>
    <dbReference type="GeneID" id="27900607"/>
    <dbReference type="HOGENOM" id="CLU_2251739_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF17023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="104" mass="11623" checksum="A96FA1E7BEB26DA5" modified="2013-06-26" version="1">MARARPDATNLRDYSFTSSPYTVLLLTSTMTKSLPTVPNLLYSDRTNHPRGQAALHPRQPIVAARNAFGKTTAKSAQRALILVPSISFGRQFRGSDEHVYIYSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1QMF9</accession>
    <name>N1QMF9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peroxisomal membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_137367</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764730.1">
        <property type="nucleotide sequence ID" value="XM_016902836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QMF9"/>
    <dbReference type="STRING" id="692275.N1QMF9"/>
    <dbReference type="GeneID" id="27899973"/>
    <dbReference type="eggNOG" id="ENOG502RXMH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054132_1_0_1"/>
    <dbReference type="OMA" id="VMVFLFR"/>
    <dbReference type="OrthoDB" id="39659at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019531">
        <property type="entry name" value="Pmp4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15460">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15460:SF3">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF013674">
        <property type="entry name" value="PXMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF16609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="233" mass="26039" checksum="41340BA3BC362241" modified="2013-06-26" version="1">MSSLQALQSSLESIILDPQYKAPLTLVKAIRNGAVYGTKVRFPHALVMIFLFRSGTLREKIYLVYKATRQHASNLARFALLYKSGMLLLRKANSGKEAPFHSFLSGLHGGYWVFGHGKGAKSSVNQQIVIYVFARVVLALAKLAVQPPGDNALVGSSYGGHGGKGLLTLSEEQRAFIRRYSWPVFASMSWASVMWLFEGYPETLQPSLRSSMTYIYGNAEKWDSLRNFAWHNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1QMJ2</accession>
    <name>N1QMJ2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">POPLD-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_145860</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764785.1">
        <property type="nucleotide sequence ID" value="XM_016903307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QMJ2"/>
    <dbReference type="STRING" id="692275.N1QMJ2"/>
    <dbReference type="GeneID" id="27900444"/>
    <dbReference type="eggNOG" id="KOG3322">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007205_0_0_1"/>
    <dbReference type="OMA" id="KALSPMC"/>
    <dbReference type="OrthoDB" id="442863at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039182">
        <property type="entry name" value="Pop1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055079">
        <property type="entry name" value="POP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009723">
        <property type="entry name" value="Pop1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012590">
        <property type="entry name" value="POPLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22731">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22731:SF3">
        <property type="entry name" value="RIBONUCLEASES P_MRP PROTEIN SUBUNIT POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22770">
        <property type="entry name" value="POP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06978">
        <property type="entry name" value="POP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08170">
        <property type="entry name" value="POPLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pop1 N-terminal" evidence="5">
        <location>
            <begin position="70"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="POPLD" evidence="6">
        <location>
            <begin position="560"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="POP1 C-terminal" evidence="7">
        <location>
            <begin position="744"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="87"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="781"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF16664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="894" mass="99459" checksum="3C27D3CC5FD62F1F" modified="2013-06-26" version="1">MAQQHPPKTPATGNAGSKKRKDPPTNASNLKSDKKRPKNDHRAKQRDARTLSTQTSSKAFKNGQLDVDNFVKSREYEIRAMEEGMSRSKQALSKRAFQQVPKDLRRRTASHNVKRVPKRLQPRAKREMVEDNTPTVTSRRRKPTRHMRLRLETVKKLRALGSKRKEAKEKSADSNITVRPVEQTVRPETKVDAAVKARTPRIKKAKLAAPPKPKAKFRKRQIDKTWLPTHMFHAKRARMTTPKEPLWRFAIPLTPTAKSYRPTHRAASEKGAIAWDMSYMSTISLDGQQRSIEGMLKALCFSPVSSSDDPWGSKCERWRNGITMMEGMIFEREAPHKPIAPTAAIWSTLSAPKFSGPDELVAKRNRKLMLRMHPSAFPQVWEELVRLGKVAKPQVSVEDLRYEIGSIEVAGAGATEALVGALWPSTDSATSIAQIAKVWPALAGLTDPSLLPSNVIIACDMQDPRLHHPPRTIKISQNSDEQQRLSELAAAWPLKSEHISANLFDRHARRITSSALSSQKAINRRKSAALPGQFPDAISTDPKIPTMVYSTSTGKGSCGSWTVLLPWKCVQPLWYSILYYPLSSGSQPRFGGLAEKRQLAFEANQAWFPGDYPGTSAGWEWEVEQRKKRKDEWERRPKSKRVNWVTVATGSAIKGEIGSGWACDWEQLLGGPNTEAHAGGAAGQAANEDITMVNGNAAEAAGPAMPVQVTAQPPVTFLPSLEAERLFQTIADNDLPPNLRNPVIIVSLSCLTRGTPQTCARIYRLPSTTTSAPLRRKWLDLHPRNKNQKGPKNSLPRLPKDAPPYLVQRRLAQSLLEPVRAGEDDYPTCPAEEDLIGYVTTGNLNLSEGRGTGIGNLLLSRVLNDVRQNRDDGRLCIVRNAGQSVGRLARWTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>N1QML3</accession>
    <name>N1QML3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mediator of RNA polymerase II transcription subunit 31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_145889</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Mediator complex subunit 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764825.1">
        <property type="nucleotide sequence ID" value="XM_016903323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QML3"/>
    <dbReference type="STRING" id="692275.N1QML3"/>
    <dbReference type="GeneID" id="27900460"/>
    <dbReference type="eggNOG" id="KOG4086">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071681_4_1_1"/>
    <dbReference type="OMA" id="YWSRPPY"/>
    <dbReference type="OrthoDB" id="10257739at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1340:FF:000002">
        <property type="entry name" value="Mediator of RNA polymerase II transcription subunit 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1340">
        <property type="entry name" value="Mediator of RNA polymerase II, submodule Med31 (Soh1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038089">
        <property type="entry name" value="Med31_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008831">
        <property type="entry name" value="Mediator_Med31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13186">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05669">
        <property type="entry name" value="Med31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0010">Activator</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF16704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="114" mass="13060" checksum="1D933702D3E2719E" modified="2013-06-26" version="1">MADSSNSAGSTASAARYGGHDRFTLELEFVQMLGNPQYLQHLADKKLLENDEFVAYLDYLRYFKDPKYLRFLQYPGPTLRALELLQEEQFRKDILSPEVMSRVFQAGLDASNST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1QMN4</accession>
    <name>N1QMN4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dfp1_Him1_M-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_145918</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764865.1">
        <property type="nucleotide sequence ID" value="XM_016903340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QMN4"/>
    <dbReference type="STRING" id="692275.N1QMN4"/>
    <dbReference type="GeneID" id="27900477"/>
    <dbReference type="eggNOG" id="KOG4139">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017715_0_0_1"/>
    <dbReference type="OMA" id="GMKIWAI"/>
    <dbReference type="OrthoDB" id="21380at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031431">
        <property type="term" value="C:Dbf4-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010571">
        <property type="term" value="P:positive regulation of nuclear cell cycle DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901987">
        <property type="term" value="P:regulation of cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00027">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3410:FF:000001">
        <property type="entry name" value="Protein DBF4 homolog A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3410">
        <property type="entry name" value="DBF zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055116">
        <property type="entry name" value="DBF4_BRCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013939">
        <property type="entry name" value="Regulatory_Dfp1/Him1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051590">
        <property type="entry name" value="Replication_Regulatory_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006572">
        <property type="entry name" value="Znf_DBF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038545">
        <property type="entry name" value="Znf_DBF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15375">
        <property type="entry name" value="ACTIVATOR OF S-PHASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15375:SF26">
        <property type="entry name" value="PROTEIN CHIFFON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22437">
        <property type="entry name" value="DBF4_BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08630">
        <property type="entry name" value="Dfp1_Him1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07535">
        <property type="entry name" value="zf-DBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00586">
        <property type="entry name" value="ZnF_DBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51265">
        <property type="entry name" value="ZF_DBF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DBF4-type" evidence="6">
        <location>
            <begin position="605"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="19"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF16744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="658" mass="73424" checksum="1727310699C81B1A" modified="2013-06-26" version="1">MASRRAPLAAVPNAVNSPMRSVSAVNGKRTRAHAGEQQSVYGQPPVKKHIVELPAGNEENVDPRRRIGVPALGLDKLEEPFLKRASHAPPTAFEKKLASVRDKRTTPQHTQQLREGRLQKQHADNIESIRQWQRHYRRQFPGFVFYFDSVSDEIRHKAVHKVQALGAREDKFFSNAVTHVVTSRAIPTETANTSPDHDENEALRQRSVQQLLPNTNPRRPTSALDTHIQRRSQLSLASVQPSLETRRTQSHSADILSKARALGTKIWALEKLHRVLDTILDNDAGEHAVDSRGTAVNRPPSNNARDADLEQLLRHEKVKGPTDRDMTVATQDVITLRGCYIYVHDMDEKTKPVMVRDYSKPQTKEQGKWPQFRLSAPGRCPFIEDPAYAKKKMVQEDREVLEPRDVVQRKTRAGVASQLVPPLATITGNEMTLRRSPRTLAQNDMAGMTQPPPPPYPGVARRQPSVEASATFYNSAQANMRGPPRMVRGEPVASGVQPSNVTSAIRSQAVSSAAISSTTGLSRRVGDSREMSLLKRKVLTSTSIPTSYANDVRAAINDDSAPPPRAAKRKAQETLGVVYEHENGGTGARQACATTAQKRKKVVEKEAKPGYCENCRDKFDDFDDHIASRKHRKFATAAENWQELDELLALLKRPHKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1QMW1</accession>
    <name>N1QMW1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Pkinase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_146698</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765853.1">
        <property type="nucleotide sequence ID" value="XM_016903805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QMW1"/>
    <dbReference type="STRING" id="692275.N1QMW1"/>
    <dbReference type="GeneID" id="27900942"/>
    <dbReference type="eggNOG" id="KOG0661">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011172_0_0_1"/>
    <dbReference type="OMA" id="GNWYNKA"/>
    <dbReference type="OrthoDB" id="2158884at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07830">
        <property type="entry name" value="STKc_MAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000233">
        <property type="entry name" value="Meiosis induction protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000314">
        <property type="entry name" value="Serine threonine-protein kinase mak"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="27"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="365"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="481"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="622"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF17732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="791" mass="86987" checksum="93BF4DF18BA151F2" modified="2013-06-26" version="1">MTVAYDMSSYRGWSSSSQTAVCLEDKFEILKDIGDGSFGSVTLGRTRSAGAHIVRRGTLVAIKTMKKTFENFAQCMELREVIFLRSLPNHPHLVPAYDIFLDPLSKKLHIAMEYMDGNLYQLMKARDHKPLDCSSVKSILFQILGGLEHIHDHSFFHRDIKPENILVSTSAPDSGSTFKRYSSLVTPPSTPPAYSIKIADFGLARETHSRVPYTTYVSTRWYRAPEVLLRAGEYSAPVDIWAVGAMAVEIATLKPLFPGGNEVDQVWRVCEIMGSPGSWVNKHGHKVGGGEWKEGIKLAQKLGFSFPKMAPHSLETVLPAPHWPASLAHFVTWCLMWDPKVRPTSRQALEHVFFQDALDPLRPKSAAAQKALGRKSSTHLGATDSTDSVPSLTTKTSSWFRKSLGPRDSSAPPVPEYPQASNKESPRPTPLQANTSDTSAAVEKGRPNPTKRATWANGVSNAAPIPILPSIRPISPLRDESVAQANVSRTEQPDERPGKKIGRQLSVNSQGNHYAEIHRQEAERALNGNSGLKSPTGSQRESFFSHLRKRARRFSGKPTGPTSPTPDDMEANVGCAPWTTNRQSMQPEPQAIAPNAADPSVDPNFAELDRALQNVRYSLDAAASAAPSQPKPPVRMASNPTLKRHHSLPYGKEEQTASVRSRRPVKPAPGNVRYEAPCEEDELLDEALASAHRAVTRLDHGVAPSARPLLPHVTSEPTYNVPYLTPSHSKDQMAVDYVTNDSTPSKPVNIPPMRQQEKAVVNPQWPTPPYDENDWASGVAASIFATQASFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>N1QN11</accession>
    <name>N1QN11_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyldiphosphate specific]</fullName>
            <ecNumber evidence="5">2.5.1.87</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SEPMUDRAFT_77767</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>n isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = a di-trans,poly-cis-polyprenyl diphosphate + n diphosphate</text>
            <dbReference type="Rhea" id="RHEA:53008"/>
            <dbReference type="Rhea" id="RHEA-COMP:19494"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:136960"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.87"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the UPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.87" evidence="5"/>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765584.1">
        <property type="nucleotide sequence ID" value="XM_016910172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QN11"/>
    <dbReference type="STRING" id="692275.N1QN11"/>
    <dbReference type="GeneID" id="27907309"/>
    <dbReference type="eggNOG" id="KOG2818">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051870_1_0_1"/>
    <dbReference type="OMA" id="AWSSCAG"/>
    <dbReference type="OrthoDB" id="19639at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904423">
        <property type="term" value="C:dehydrodolichyl diphosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045547">
        <property type="term" value="F:ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="entry name" value="Decaprenyl diphosphate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038887">
        <property type="entry name" value="Nus1/NgBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21528">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT NUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21528:SF0">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT NUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="Undecaprenyl diphosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="191"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMF17463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="344" mass="39002" checksum="3E01544047ABC5F3" modified="2013-06-26" version="1">MPGLREQAAFRRPDTLSPTQREQLLAPYLPREPIASRTKVPQDASYSNSNNHGLRFHHRQRVRPAMRHLLHLFLFTAVHVVFSIYVRLRQIYHALYDRVSAVLYYHHRTPELITRDVKPLTRVPKHLSVILHLPPEGGKKDALETLLNDACELVAWSASAGIPTLSIYEKTGILKSSLPHLHRRITRTLTSYYGTSSPQKPTMSLRSPNLPSYSPPHSPELDTMSTTSPSPLPPHINVLLLDSTDGRQTIVDLTKTLTEMSQSGKLLPADVSQELIDAEITESVMGEPDLLIVFGERVVLEGYPPWQIRLTEIFYAQDNVGGVGYQIFLRALYRYAKAEFRFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1QN28</accession>
    <name>N1QN28_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_146121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765125.1">
        <property type="nucleotide sequence ID" value="XM_016903463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QN28"/>
    <dbReference type="STRING" id="692275.N1QN28"/>
    <dbReference type="GeneID" id="27900600"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078327_0_0_1"/>
    <dbReference type="OMA" id="CLFVTET"/>
    <dbReference type="OrthoDB" id="19174at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF17004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="229" mass="24625" checksum="7159A94369BAFE4C" modified="2013-06-26" version="1">MSQVPTIDILLNLVPERPVVVLEKLRAHPALAHKQDMHGYSLVHAAASYGHSELLKALIEDFSVDPNIKDEDGETALFSVEDVTMAKELLDLGTDPQSRNDEGQVAAEKLADDDEQPAVAAFLRDVAGSAASGNGLTPLPNGDAHSSHHPPPLPNGLELNIGTMMPEEEAADPEFRRRIEELAARSDFETEEGQQELRNIIMDALSGSAGGDAQGPPASRRRIDGSDRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNM4</accession>
    <name>N1QNM4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RSC complex subunit Rsc9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_146449</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765535.1">
        <property type="nucleotide sequence ID" value="XM_016903660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNM4"/>
    <dbReference type="STRING" id="692275.N1QNM4"/>
    <dbReference type="GeneID" id="27900797"/>
    <dbReference type="eggNOG" id="ENOG502QVTM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008152_1_0_1"/>
    <dbReference type="OMA" id="DKYKFDS"/>
    <dbReference type="OrthoDB" id="338531at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16100">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052406">
        <property type="entry name" value="Chromatin_Remodeling_Comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003150">
        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22970">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22970:SF14">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51526">
        <property type="entry name" value="RFX_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ARID" evidence="6">
        <location>
            <begin position="12"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="RFX-type winged-helix" evidence="7">
        <location>
            <begin position="623"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="132"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="857"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="157"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="178"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF17414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="971" mass="107973" checksum="C201EE499FA49406" modified="2013-06-26" version="1">MAPKRGQSIEPTPERDEFMKKLAAYHEARGTTLETEPRIGPRRVDLFNLYTRVVGEGGYDLCSDTKAKPLMWRRFAEEFIGKNQYTAAQAFQIKNVYYKNLCAYEISTHWGQEPPPKQILEDVTAKGGNVMTRTLDNYERPKPREETTLNGETSDGSPEHRTPKEVKSELVEEPGSATGRTTRGLRQQPPQRVLFQPDASAVRQARAHPHPPGASPTPGATVNGVTHSSSATNGASSTLASYEPPQAYPLSLKPVNTPANNPDHYRNERKRKLDARAGPLAKKYKNIMLPGTGFIGPNIYVRAQLALQSGMPEEEQYALHHLVKISHERGDKYRFDQFPGLAEALIKKTLQVTSLFYDIDWDVMYDEEFFAGDDETLNGLDGTPDILQKLRSRLPIVSEDTVVDSQFCTSMSRVTEAGLVLRNMSLQDENAAYLSRLPLAQDLIAVVLNLPEHASVSELRHHILDLSEQVLKYVDVSPYSAVYQGLLRHTLGCDRGAIATALRSISRIAMTHPSPKRLEDIPVSLLRRIVDYLHLEDEELRSACLDLLGQYTSFGDNVETLVRVADVEALGRSLSRLVLFTAREYTESRPPRHREIDDSVAPVPRLSKALVHELLTLEEPERSSEWLRMCFLSDPNAEMTQISLWQAYQGTFAPHQATHPHLIAGDFIKNVSNTFQGATAQVAGSNKYVIKGIKSRKAPVDTGMLAGSTAADKDKELIRCHWRMSYPVEGVRDAITGLVSAPTTREIECAEWFRTGQQIHEHILASHLQIPKKLSSAEADKMDVDIVPARSTPVSVNGLTNGDAEHSWTASFDFSNTDRAIYRCKWSDCTHTCTAPERSKVSSAWVFARHMETHLPETDPSRLRHNLPPGGGTNTSGDITRISMLEDEDGDAAGVPLRAALVLRNLARFMPKAVLPIGNRATKAGKKTQHDLMSAVFSSEVNERLLYAMSHGHGIKDYVGAIFRAVKANST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M3AT61</accession>
    <name>M3AT61_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleolar protein 56</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_151674</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for 60S ribosomal subunit synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756825.1">
        <property type="nucleotide sequence ID" value="XM_016906973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AT61"/>
    <dbReference type="STRING" id="692275.M3AT61"/>
    <dbReference type="GeneID" id="27904110"/>
    <dbReference type="eggNOG" id="KOG2573">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015495_4_0_1"/>
    <dbReference type="OMA" id="PDNYMFA"/>
    <dbReference type="OrthoDB" id="6780543at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000494">
        <property type="term" value="P:box C/D sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000452">
        <property type="term" value="P:snoRNA guided rRNA 2'-O-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000001">
        <property type="entry name" value="Nucleolar protein 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4070:FF:000002">
        <property type="entry name" value="Nucleolar protein 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012974">
        <property type="entry name" value="NOP58/56_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08156">
        <property type="entry name" value="NOP5NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Nop" evidence="8">
        <location>
            <begin position="300"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="447"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="469"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="535"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF08704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="546" mass="59925" checksum="ED59977E7642D1A1" modified="2013-05-01" version="1">MSVDYLLHESSVGYAIFQVKLQSDTIGARLKEVQDSQTDLAKFGKQVQLVSFTPFKGAQEALENANDVSEGIMSELLKTELEANLPKAGKKSKVSLGVGDKSLAGSIKEAFPGVQCETPETSELAADLLRGLRTHAEKLLKTLQNGDISRAQLGLGHAYSRAKVKFSVQKNDNHIIQAIATIDHLDKAVNTFSMRVREWYGWHFPELIRIVSDNHKYARCALFIGDKKTLSEDSLHELAALVDDDESVARAIIEAARVSMGQEISENDMENVMTFAKRTAELAAYRKKLGNYLVAKMGIVAPNLAALIGETVGARLISHAGSLTNLAKYPASTVQILGAEKALFRALKTKGNTPKYGLIYHSSFIGRAGMKNKGRISRFLANKTSIASRIDNFSMAPTRVFGEALRAQVDERLRFYAEGVNPMKNADAMKAAMDKTLATIDVADPTADATGEVPNKKEKKSKKSKSEDVEMADIDADAITDKSSKKSKKEKRKSEAMDIDVDEAAVEKKLKKEKKEKRKSEGLANGEVPEEQIKEKKKSKSKKSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M3ATG7</accession>
    <name>M3ATG7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HNH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_158922</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756930.1">
        <property type="nucleotide sequence ID" value="XM_016907812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3ATG7"/>
    <dbReference type="STRING" id="692275.M3ATG7"/>
    <dbReference type="GeneID" id="27904949"/>
    <dbReference type="eggNOG" id="ENOG502S89B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074184_0_0_1"/>
    <dbReference type="OMA" id="WHDEWML"/>
    <dbReference type="OrthoDB" id="4850648at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37827:SF1">
        <property type="entry name" value="HNH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37827">
        <property type="entry name" value="TUDOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF08809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="264" mass="30003" checksum="92DA4A12FD032E50" modified="2013-05-01" version="1">MTIPQMIAENEVENFENFKDCLSNTVIQKLAPNGGKPVKKIKGRKNEIKPVTRVVESNGEDSNDAADLADFIEYLAEEIFLSLPFDLRTLSYASIQDDSSLAEKYTTPLESPLLEAIMKPLPLAIADSLVTYSLIVDPLDLDRFLETPLNAYVSSVSAAPPEHTPAIAASRPDGCEICQREHLPLTYHHLIPRAVHAKAVKRDWHKEWELNKVAWLCRACHSYVHRVASNEMLAKELFSVERLMERDDIQKWAQWVGRVRWKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M3AU02</accession>
    <name>M3AU02_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Intradiol ring-cleavage dioxygenases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_151844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757075.1">
        <property type="nucleotide sequence ID" value="XM_016907075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AU02"/>
    <dbReference type="GeneID" id="27904212"/>
    <dbReference type="HOGENOM" id="CLU_1200447_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004031527" description="Intradiol ring-cleavage dioxygenases domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF08954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="231" mass="24542" checksum="51FC307CA50FA9C5" modified="2013-05-01" version="1">MKTFVVIAALSTISLATPANLPLIGFANPTIATTFLGIDTGDPTPTAEPSPTPTIDFDNGTPPTLAPGAGRHVYVETSSDSSLVNQWLVVSPNPGNPVTFTTNKALAANWTTTQDSSVKDDENPNGDAMIDTATGFYAYINGSFFPGDTQVHVYDVLFQDTPLGGFSPIIPVVSSITQSVQMAKLTINLFGKIQEERLNIIQTCGGDVGPHLVLSEFFVDGCQNLTLRYAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M3AXM5</accession>
    <name>M3AXM5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Stress response protein Rds1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_150406</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759611.1">
        <property type="nucleotide sequence ID" value="XM_016906155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AXM5"/>
    <dbReference type="STRING" id="692275.M3AXM5"/>
    <dbReference type="GeneID" id="27903292"/>
    <dbReference type="eggNOG" id="ENOG502QSE0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028606_2_0_1"/>
    <dbReference type="OMA" id="TEPRYMV"/>
    <dbReference type="OrthoDB" id="2098436at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039254">
        <property type="entry name" value="Rds1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38705">
        <property type="entry name" value="PROTEIN RDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38705:SF1">
        <property type="entry name" value="PROTEIN RDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13668">
        <property type="entry name" value="Ferritin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004031177" description="Stress response protein Rds1" evidence="2">
        <location>
            <begin position="23"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF11490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="562" mass="59590" checksum="6263125E856AD4D6" modified="2013-05-01" version="1">MLRSLITLAGVAAAIPAPQVSQLPDGQVQAPAYGAASSATAIAQTTAAAVSTAPTPAAYSGSTRGSDSGSGSGDGNGNAADQSGNVDGYINADAPYASEQPTPLTVVPSVFGPDSQIPAVATSVTGPLNGAPQRSRYVTGTTTHGPFEGTATVTGAVSNSVLASSVGTLPPNPTATYYNTNGLLQNPQPAPYTPAGGLGTNGSLPRYMVESDFDYESITLGLYQEWIELDTFNNAVATFSEEDFAAAGLGPEDISLIQFMAQQEQGHATLLSNMLGETAPPQCTYNYPYTNVREFVDFNQQLTRWGESGVWGFINHLDSREVGQLLAQSIATEARQEMIFRQMSGLHPMPVWFETGIPQSWAWTFLAQYISSCPEGTTRLAWQNFPNLHVVNQANINRFSPNDTADYERVDNRTSSPATIPAQKDSCINVNATEHPGYGCGPAITHNRSEPLSFPGKQVRFLWDAPGMAVGPNNSYTTSTSAGEPKFVAWAAQLNLTYTPLTITGPNEGYTYQPAGTVYEGGQGIVNDTMFVALTDTDMFLTPFNLSMINPHVVALGVYQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>M3B1Y4</accession>
    <name>M3B1Y4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_156001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761923.1">
        <property type="nucleotide sequence ID" value="XM_016907651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B1Y4"/>
    <dbReference type="GeneID" id="27904788"/>
    <dbReference type="HOGENOM" id="CLU_2997948_0_0_1"/>
    <dbReference type="OrthoDB" id="4156665at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF13802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="57" mass="6620" checksum="FC3F076C88D70D24" modified="2013-05-01" version="1">MAVFGSIPGHLIHARTMRDCRRARVDSGHRHVTGKTKRHFQPRRHLHALCLCIQDTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M3B3A5</accession>
    <name>M3B3A5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TBC-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_62492</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762398.1">
        <property type="nucleotide sequence ID" value="XM_016909604.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.M3B3A5"/>
    <dbReference type="GeneID" id="27906741"/>
    <dbReference type="eggNOG" id="KOG1102">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005062_1_0_1"/>
    <dbReference type="OMA" id="PMLFRMY"/>
    <dbReference type="OrthoDB" id="159449at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000003">
        <property type="entry name" value="GTPase activating protein (Evi5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000027">
        <property type="entry name" value="GTPase activating protein (Evi5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000001">
        <property type="entry name" value="TBC1 domain family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="5">
        <location>
            <begin position="452"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="52"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="225"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="287"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="745"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="911"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1065"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1282"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1218"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="746"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="787"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="797"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="953"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1067"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1077"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1110"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1123"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1160"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1315"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1348"/>
            <end position="1358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF14277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1358" mass="149577" checksum="A4CF2D4EB78C833A" modified="2013-05-01" version="1">MIGTAISPHILAPTLGAQAGPELTTVERPTGAAETMANDALATMETLQTRLDLVDHDEQSAASVMAKKTDEMRQADDQEEEKEKEEEKEEEDEDEEEHFRPSTPQHSTTSDSDTSSTPTQEAAKPTFVETITLHGEPLDDRALSSSSSSSPRPETPTDPQTPSTPHDLTRDSMASFALSDTSMDWNNLSSEAIEDVLATPRVSNTRRHLRKVSSLDILQNKFAAPDKPTTLFDSDENSRDPPMSAVELSRENNDLDAWRRNTDLLPHDYTLSHRQSVATMDSIEILEDSPLTPPSRSMSRSSSADPHNRTSDSSGEDMQVDWQALDKTEEQEKEDKAAQEGAEDDATAFLLARLEQENAKFAADPKASASKPLRRKTRAYSRPPSMAQLKRLVATSEMPSIRYSLASDTRFPPSPNETPPMTELEFWVALVQDYSSTALRLPTLTTTKIRSGVPPPLRGVVWTSMSGARDRDLEDSYERLIHEKSSYEGIINKDVGRSFPGVELFRDADGDGQKMLGRVLKCFSLHDKDIGYCQGLGFLVGPLLMNMGERDAFCVLVRLMDHFSLRASFLPSLSGLHMRIYQFSALLKQHHPKLQEHLAKHGIEPAYLSQWFLSCFAVTCPLNLLFRIYDVIFAEGANETVMRVALALMRRHEERMLATDEFEEVMSLLLGREMWNCYAGDADELVDDFTSLGDIVTFARLAELEKEFEKQSSEAVGQSAGFLPTVQAAASGFLGRIWAPGHAATPSKTVTNHAHNASTTTLSPETADKTRGGFFGRPSTFLRRSPSRTELHDAHDSSSSGDSGSTNGSSAVSLTSTIMTDPDTPLAHGQGMRESIADSISTKSKADSMYPQSTSLLISQQRDLQAQIEDLLTAMGEMQREQAQLAVMLQKEREERSEDHKIMRQMVAKLRKDKTDRRKTMPPPPRNQSPLEVPLPTSRPLSVGDFTQLNIDGTDKEPPERDEMEELVEKAQERLQTSVRFSMSLETKANLRSTLARAREELAVAEAQSRDLAIRLEASQSAVIAFQEEGDDLRSEVKELRQRVADEFKARQRLEHKIGELNAQTRSIERKERQYRSESLQQVPTLSKSGDASNPQGRKGSTSSMPGGLRELRLGRRDSSSSVHNTRSQSLRNTSPPATDVPLPTLRTEPASADGTPATSPSQSDIASPSSVPPAGEQLAAPVGRRGFSKRTSSLATQDVFATTQHEVVPEEALLLELVNAKTAEAQALQELDEVKKALSVSKRRQEETMTRMRAEIEAAKTEAKLAVEKVEAAKVPSEPAIASPMFSQPSTPFAEGSNPLAPAGKVSSGTGTPADDRPESELNVAKKGEDKSAVAPVGWFWQRRTASKSTNVSPAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M3B6K6</accession>
    <name>M3B6K6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Probable aspartic-type endopeptidase OPSB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Probable aspartic-type endopeptidase opsB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_80074</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763528.1">
        <property type="nucleotide sequence ID" value="XM_016910234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B6K6"/>
    <dbReference type="STRING" id="692275.M3B6K6"/>
    <dbReference type="GeneID" id="27907371"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013253_9_3_1"/>
    <dbReference type="OMA" id="CNVTLGT"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05474">
        <property type="entry name" value="SAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000011">
        <property type="entry name" value="Aspartic protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033876">
        <property type="entry name" value="SAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF65">
        <property type="entry name" value="ASPARTIC-TYPE ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 9" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidase A1" evidence="10">
        <location>
            <begin position="73"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00068059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF15407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="471" mass="49286" checksum="013FF3DEAA9BF945" modified="2013-05-01" version="1">MRSPTIAYTAGILATASNAINLVKRNDALPPRVVEHTIQRKDIRNPLDHDRKRWQRRKRDTLTVALDNEETLYFANVSIGTPAQNLRLHLDTGSSDLWVNVDSSALCQARGDPCSISGTYNANDSSTYTYLNSDFNISYVDGSGSAGDYVSDTVKIGDTTLTGQQFGIGYESSSQEGILGIGYPINEVAVQYNGGKTYSNVPQSLVKAGAINTNAYSLWLNDLDASTGSILFGGVNTEKYTGSLETIPIVETQGVYAEFIIALTAVGANGTAGSIVNKQAIPALLDSGSSLMYLPNDITQSIYDSVGASYDSEQGAAFVDCDLANSDGSLDLTFSSPTIKVPMNELVIVAGIDRGKEVCILGIGPAGSSTPVLGDTFLRSAYVVYDLAKNEISLAQTNFNSTANNIMEITTSTVPDATLVTNAVTSLAVSSGGARINSGTTVTLDGAAPTAGPGWSVAAIGAAAGAALYAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M3B790</accession>
    <name>M3B790_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TFIIS N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_147524</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transcription factor involved in RNA polymerase II transcription regulation. May function in both SPT15/TBP post-recruitment and recruitment steps of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IWS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763843.1">
        <property type="nucleotide sequence ID" value="XM_016904351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B790"/>
    <dbReference type="STRING" id="692275.M3B790"/>
    <dbReference type="GeneID" id="27901488"/>
    <dbReference type="eggNOG" id="KOG1793">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045275_1_0_1"/>
    <dbReference type="OMA" id="MPAYNIQ"/>
    <dbReference type="OrthoDB" id="21124at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051037">
        <property type="entry name" value="RNAPII_TF_IWS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010:SF1">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="5">
        <location>
            <begin position="299"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="447"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="447"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00037992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF15722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="480" mass="53586" checksum="4C4F01C730EA0B8C" modified="2013-05-01" version="1">MEDLEQPDVPTVDSIDNEPQANADPNDPLRPEIEEEDNAGGTPPMADPHADTEVQENGGSKSADELMDDEADAEKPVNGEDDNEDNDDESELEELDEQEFADFDATALNIPDKPIDVDESNVALLGVHKRKRTAEEEAERERKKKKKEKKREKPSSRKRRGGEDEDDFEGGPEMDGKRSRKSKGSKPSQSSRRERTPIDLDTLPPDERRRRALDAKMDEALKTHRVSRRKAAQDMEERADQEIAEMRTRIAKACELDAQARSRGDVAVQKLKILPEVVELMNRNTIQSQLVDPDINILESVRFMLEPADQDAALPNYQIQRELFAILSRLNIGKEALVASAVGKVVLFYTKSTQPQPDIKRQAEHLVAEWTRVILNKGKDARSKPVETRGYDPMAAAASQRMGPSQVDRATLAAEKRKRALEAPGPQNRARVQGGVGTYTVAPVSNMSNAQGVSQRKTQGANDETFRRIAARSSQKMGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M3BNX3</accession>
    <name>M3BNX3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Histone-fold-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_55243</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone H3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456310">
        <property type="protein sequence ID" value="EMF07878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016755999.1">
        <property type="nucleotide sequence ID" value="XM_016909351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BNX3"/>
    <dbReference type="STRING" id="692275.M3BNX3"/>
    <dbReference type="GeneID" id="27906488"/>
    <dbReference type="eggNOG" id="KOG1745">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078295_7_0_1"/>
    <dbReference type="OrthoDB" id="842664at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45810:SF1">
        <property type="entry name" value="HISTONE H3-LIKE CENTROMERIC PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45810">
        <property type="entry name" value="HISTONE H3.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="5">
        <location>
            <begin position="6"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF07878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="111" mass="13001" checksum="3FD42E1C41F7E0A8" modified="2013-05-01" version="1" fragment="single">RRTKPSVAALREIRRYQKTTELLIRRLLFQRICREVTIDIASKSSSSVCRFQAEALLCLQEATEAFLTLEFEVSNMLAIHAKRVTLQQKDIVLCRWIRKRFLGENNGKDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M3BP06</accession>
    <name>M3BP06_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_145509</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456278">
        <property type="protein sequence ID" value="EMF07908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BP06"/>
    <dbReference type="eggNOG" id="ENOG502SGSK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_204430_0_0_1"/>
    <dbReference type="OMA" id="VMIKRDS"/>
    <dbReference type="OrthoDB" id="3623799at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF07908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="61" mass="7156" checksum="BBD3F73F5578D44E" modified="2013-05-01" version="1">MINRDSRGHPYSIVRGEILGFIEDELLRKHLPRMFSLISERKLGDRRRSDTVVVLTINYAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M3BSI4</accession>
    <name>M3BSI4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycoside hydrolase family 32 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_151901</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF09053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757174.1">
        <property type="nucleotide sequence ID" value="XM_016907114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BSI4"/>
    <dbReference type="STRING" id="692275.M3BSI4"/>
    <dbReference type="GeneID" id="27904251"/>
    <dbReference type="eggNOG" id="KOG0228">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013784_3_0_1"/>
    <dbReference type="OMA" id="IPREMYV"/>
    <dbReference type="OrthoDB" id="202537at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18621">
        <property type="entry name" value="GH32_XdINV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.560">
        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800">
        <property type="entry name" value="EXOINULINASE INUD (AFU_ORTHOLOGUE AFUA_5G00480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800:SF3">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY 32 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032334" evidence="5">
        <location>
            <begin position="20"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 N-terminal" evidence="6">
        <location>
            <begin position="64"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 C-terminal" evidence="7">
        <location>
            <begin position="471"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF09053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="648" mass="71679" checksum="57A2E37937C63737" modified="2013-05-01" version="1">MRPTTSAVAFLAALPLCCAWSVPALEKRHYPTTPQNESCSSITAAEIRSMGNNTLFTRWRPTSHFLAPAGWMNDPCAFMYDPVRDEYHGYYQSHPEHISWGNISWGGAKSKDLIHWEDIGGWQGREPLSLSPGANGSYDQLGIFSGTAQPVNLQGEQDGTLLIFYTAVSYLPTNWRSHYEPGTETQALALSHDGGETWEKYDGNPIINATTETAPMNWNLTGFRDPFFEPVPELDELLQVDEPHYYAVYGSGIKGVGPRIPLWAAPARDLTSWTFLGALWEPVANTSVGPVLSTGSYGFNFEVSGFFPLKDRAGKDHWYVNMGTEGGNVSFHSSPQWSLWNEGHVVRRENGSAEFVPLTGGAGDWGLGYALTSFNDTKNNRRVQYAWLKEDNVGDGGLFSANQQGFQGALSIPRELFVHEVDHVVNTTELTESKTAIVENGTARTLGVRPLDDVVAGLRNGSTYAAYSAKTYNESTILSQCATSHMEIKTTVKNATGPVGLRIAASSDMEEYTTIMYEPSNHTILVERLHSSNVVEFNNETITGYFQPYTLLTTNQTESLTFDVFIDGSIVEIYVNERFALTARIYPSKSCSTGYGVYVGKGSTAEFDIVHAWVGTDNAWPQRPVNSSSQLVWDTVEETNNRTWWAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M3BSJ9</accession>
    <name>M3BSJ9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_93513</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF09068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757189.1">
        <property type="nucleotide sequence ID" value="XM_016910620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BSJ9"/>
    <dbReference type="GeneID" id="27907757"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="OMA" id="VILDVWY"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000188">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF50">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00840)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF09068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="446" mass="49684" checksum="213930E1FA74A3CC" modified="2013-05-01" version="1">MMYLFNSLDKANLGNAKTAGLEKDLGFAGTNKYNILLSIFFVPYVLTAPFLGIVGKIYGPSRVLPCMMLCFGSMTLLVTAVHNWGGLLALRWFLGMAESAFFPLVIYYQTQFYRRGELARRLAIFYAASNIAYAFGGLLAYGVFQIKSGALPAWKYLFAIEGSLTILGSIIAFIYLPYNASTAKFLSPEEKQLAFYRIQIDSSSEVNSTFNFSSALKILHHPTSWIILAIEICLGIPLQSVSLFLPQIVARLGYSTIKTNLYTVAPNCTGAVMLLLLAYTSDYTRLRFPFVALGFFFTFCGFVIYGALPHVDDSAQHLHVAYFACFMMTWGTSAPSVILDVWYNNNIADESRRVLLTSIGVPVANMMGVVSSNIFRPQDAPDYIPALATTAGFGGVGILLTLGLGAWMMWDNRRRDLRQGVKRRARDVPTERLRDGPDCEDFRWFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2022-12-14" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>M3BSM4</accession>
    <name>M3BSM4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_151929</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF09093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757214.1">
        <property type="nucleotide sequence ID" value="XM_016907133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BSM4"/>
    <dbReference type="GeneID" id="27904270"/>
    <dbReference type="HOGENOM" id="CLU_2020849_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF09093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="123" mass="13410" checksum="2276F72EB6706BDC" modified="2013-05-01" version="1" fragment="single">MDDSAGASTTGEKSMHFEHMQWRMEIERDAAHSAQCSLRLHGMAWIIIPRRLPGTLQIQVAAWLDTVVSRQQHLQRIASAVASGSAFTASTPGGSRLVGPYGLPSRSVVGIPSRRILGSKDFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M3BU37</accession>
    <name>M3BU37_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cercosporin MFS transporter CTB4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cercosporin toxin biosynthesis cluster protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_151191</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">MFS transporter; part of the gene cluster that mediates the biosynthesis of cercosporin, a light-activated, non-host-selective toxin. The perylenequinone chromophore of cercosporin absorbs light energy to attain an electronically-activated triplet state and produces active oxygen species such as the hydroxyl radical, superoxide, hydrogen peroxide or singlet oxygen upon reaction with oxygen molecules. These reactive oxygen species cause damage to various cellular components including lipids, proteins and nucleic acids. Responsible for secretion and accumulation of cercosporin, but does not play any roles in self-protection against the toxicity of cercosporin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the major facilitator superfamily. CAR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758301.1">
        <property type="nucleotide sequence ID" value="XM_016906663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BU37"/>
    <dbReference type="STRING" id="692275.M3BU37"/>
    <dbReference type="GeneID" id="27903800"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_1_2_1"/>
    <dbReference type="OMA" id="GLQMYDG"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF68">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="332"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="429"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="484"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="519"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="107"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00053977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00069139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00077167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF10180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="555" mass="60525" checksum="5480B528ECAF0E68" modified="2013-05-01" version="1">MAASHTNNNILSGLAGADLPEPQQKAYLEGHDADIPTDIALAKPRQSHEHDSEKSAPQSRTTFVDESLNSTVPSADDDEQDPNIVYWSSPDDAANPQNWPASTKWTQIAILSALTFLTPLASSMFAPGVPELMREFETSSSVLATLVVSIYVLGFAFGPLVIAPLSELYGRLWVYHTCNLGFIGFTIACGRAQSMGELCVYRFLQGVWGVCPVTIGGGTIADMMPPEKRGGAMSIWALGPMLGPVVGPVCGGFLTEAKSWRWIFYVIAMCTAVLAIPAFFILRETYGPVLLERKAARLRKAANNPNLRSKLDNGLTPKQLFLRAIVRPTKMLFLSPICGLMSLYLAIVYGFLYLLFTTFTFVFKDNYNFGPSIVGLVYIGIGLGNFIGLAVLGAISDRLAKALALKDQKRNGGTGGDGKIKPEYRLPPLIYAGPLIPIGLIIYGWTAQYHIQWAVPIFGTLLVGIGLIACFMSINTYLVDTFHIYAASALAANTVLRSILGGVFPLFGLQMYDGLGLGWGNSLLAFVALAMCPIPWVFYHYGERIRTHPKWQVQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>M3BVZ8</accession>
    <name>M3BVZ8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_109564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759620.1">
        <property type="nucleotide sequence ID" value="XM_016900787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BVZ8"/>
    <dbReference type="GeneID" id="27897924"/>
    <dbReference type="HOGENOM" id="CLU_1670485_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF11499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="158" mass="17633" checksum="D238F947522F1B81" modified="2013-05-01" version="1">MRSLSELLRCRERPKTARDCKALASVLTSWWDELEVAGQRAVKLSELFEAHGLGLKQAEEQQRMDAVAWRGYWSKGGGGGGIEPHHSTLPLFLQYIASATQFDGPDGRGHHNRTCEREQQQQQTTLPPINTEPKTSSCYKTSLLPMLGLQGGRYLPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M3BWA8</accession>
    <name>M3BWA8_SPHMS</name>
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        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_150484</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EMF11599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016906207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BWA8"/>
    <dbReference type="STRING" id="692275.M3BWA8"/>
    <dbReference type="GeneID" id="27903344"/>
    <dbReference type="eggNOG" id="ENOG502SR1P">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059576_0_0_1"/>
    <dbReference type="OMA" id="GWIMETT"/>
    <dbReference type="OrthoDB" id="5393606at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF157">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="157"/>
        </location>
    </feature>
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            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
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        <location>
            <begin position="43"/>
            <end position="295"/>
        </location>
    </feature>
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        <location>
            <begin position="312"/>
            <end position="338"/>
        </location>
    </feature>
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        <location>
            <begin position="312"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF11599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="356" mass="38907" checksum="154277192F418DB1" modified="2013-05-01" version="1">MYAISEASTIILTVLLTVLATLALSLRLLTANRAYKGDTFRFRWHVDDFLCVAALIFLYASSAIIIWGAAMGAMGSHSSPEDAENWYTTAGPAWIVLAKTFWVVFFLQPLQLGCIRLAILFLYRRFFGTYKSFNIVNWTLVAVVSGWTVAFFFGLLFDCGLQMDANWASLGEIAQQCPFGFLPTVIYTILDACLDLFVLLLPIPWIFQLNLSLTNKLSITGCFLLGSIATAAAFVRMTVFIQTGIPSEAMNRTTVMGLPAYDLLGIVSAEVFWTMIESTVALIAVCLPAVRKAVAKSAFGKALGFASFSRMMRSGGSSPSPSKITIRSESPDDNRCSNCSGKIPVGHVVELEKGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M3BYH2</accession>
    <name>M3BYH2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Voltage_CLC-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_148495</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016904955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BYH2"/>
    <dbReference type="GeneID" id="27902092"/>
    <dbReference type="eggNOG" id="KOG0475">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003181_2_0_1"/>
    <dbReference type="OMA" id="TDWVHDT"/>
    <dbReference type="OrthoDB" id="44789at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:Golgi apparatus"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03684">
        <property type="entry name" value="ClC_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Voltage-gated chloride channel (ClcA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF3">
        <property type="entry name" value="CLC CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0868">Chloride</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="450"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="486"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="524"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="564"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="621"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="95"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="860"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="95"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="149"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="860"/>
            <end position="879"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF13111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="972" mass="106666" checksum="40B18549FCF24CF8" modified="2013-05-01" version="1">MPKSVQSVASHVSSSFADDDDDDEDYEIDEHQAEAIRNAYRNAFASQTQNHTTATEPRDSPITRRLASQQPSDNDLAARGRPHRSLQFPADESTGLLSASQTTQSHHNYRTTAGTPATPRYGFARAQSHVNSVRGSRRGSFARGLMKTFNPNGTSPADHTSPTSSRLRQKLYWDDRVWYDQFTSTDWVHDSIADAYRVKELRSRKDFRGRVGAFFDGAQGWLLVFLIGCVTAGFAYLIDVTEATIYDYKSGYCATHWWYSKRMCCNGASSCRAWQRWSGLAGTDDGEQRVWADYGAFVCWCVGLAVLACAITLQTKTTVSSAISLSTLDEDLAADHHDPAKCGAEGGLKSGYVSPTQRFEEAARRPPVTYYPAAGSGVAEVRVILSGFVLHGYLGVRTLLCKTVALVLSVGSGMSVGKEGPYVHIATSIGNIMTRFSSKYRNNDAKRREILSASAAAGVAVAFGAPIGGVLFSLEEVSYYFPPKTLFRTFFCCIAAALSLKALNPYGTNKIVLFEVRYLSDWNFFEIIIFACLGVLGGVMGALFIKASRLWAKTFRKLSFVKKYPMLEVFIVALVTGLVSFDNRYLRLPVAELLYELAAPCSSFSSSGTTLCPTKEGIPSIIKYLLVAFVIKAILTTVTFGTKVPAGIYVPSMVVGGLLGRIVGHTVQFLVLNYPALASFAGCEDNGNPESCVVPGVYALVAAGATMCGVTRLSVTLAVILFELTGSLEHVLPFSLGVLIAKWTADALEPLSIYDLLTDMNAYPYLDHKVRPIFSTDLGDITSEPMPNRYIDISTSPFVPAKQLRSKLEYLHMAGELDGGLPILKDGILAGLIPGPDLEFALDRIPDEEEAVCRMDAHDQAVHHTEHARPSTADEHEHDISEDEEEAQSARLHHDTDDPTDLTPYIDPSPVALDITSPMDLVFECFAKLGLRYICVLHEGKYAGMVHKKAFVRYVKHVQDDYRYGRLGEGHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M3BZE7</accession>
    <name>M3BZE7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ARM repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_148719</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.</text>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761537.1">
        <property type="nucleotide sequence ID" value="XM_016905103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BZE7"/>
    <dbReference type="STRING" id="692275.M3BZE7"/>
    <dbReference type="GeneID" id="27902240"/>
    <dbReference type="eggNOG" id="KOG4574">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005652_0_0_1"/>
    <dbReference type="OMA" id="MWEISQG"/>
    <dbReference type="OrthoDB" id="2017782at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000167">
        <property type="entry name" value="RNA binding protein Jsn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052645">
        <property type="entry name" value="Pumilio_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47093">
        <property type="entry name" value="PROTEIN JSN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47093:SF1">
        <property type="entry name" value="PROTEIN JSN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="472"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="PUM-HD" evidence="7">
        <location>
            <begin position="620"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="681"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="717"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="754"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="968"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1146"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="50"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="158"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="194"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="255"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="984"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1147"/>
            <end position="1161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF13416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1179" mass="126900" checksum="80D3209728E62777" modified="2013-05-01" version="1">MAPSHRPDYKLNLEGLPQLNMHQSRSASTSQANSPIEAPAGSGLRYPLGNGLGGAGSQAGTGRAGAGSPSKEYIGSRLFPKRAREIQQQEGLTPQIWGPPTSGSGHSTPLRETIPESPSSDSFPDFNAGQATPNPASTSSSIRRTRAGTVPSRFPAMSTPNGSQSSPGVTKSSQASPSSSSYGNGSTMHEETQASAGASSRGPPASNAALLSRLRAGSLPQRAGLLGNSPFGNSVFASSWLAGRERASTLQSIRSSEGPSSPNGSPADGDVRTLDYLGLVDTPNQGSLSQINMDILLNQQRQNGVSIADLAALNAYNNKNTASRFRSYSVNAKEKYANIDQDELDDYEQVEQQLYANGTVTPNSEMTAAHAAAIHEAVRQHNIEVQAFANYASVNRPRARTAGVLDSPSSRVLRNYMPTPSRLDSSITAADLQSNDGSEYGNLAAAVHNMNLNKQASFDNGLDSGNLESPTRSLWLGNIPSSTTVSSLNVIFSQFGPIEFARVLTHKSCGFVNFENLQSAISAKIACNGKEIFPGCGPVRIGFAKEQSATNTPGATGAYPSPSPDPFLAKNRNDSAGVSTAAAGNINAETAAAALVTPDLLELREEIADIVQHFGASPEEQSRINQSLEDAMGYNGYQDEIPPILEPSHNRVHDAPRLREIRKRIDNNNVSPAEMENIAMEMLPEIAELASDYLGNTVVQKLFENSSEDTKEAMLTQLAPHLSEIGVHKNGTWAAQKIIDVARTHAQMVLIVDSLRPHGVNLFLDQYGNYVMQCCLRFQAPLNQFIFDTALNRLWDVAQGRFGARAVRACLESHFATNDQKRLMAAAIALHSVQLATNSNGALLLTWFLDTCTYPKRRSVLAPRIIPHLVHLCTHKVAYLTVLKVINQRNEPDARDSILRALFFNEQTLFDIISDQACGATFVFKVLTTPFLDENMRPECLENVRNVLTRLKAQPTQGYKRLMDEVGMSTRHGGTPVSHDGRGNSRSRQQGGNLPHGEAQNGYQRPAYANSQHIDPSMGAGLQRTISTESNGFDPYAQQQYTHSPAMSNSGIGPINVQYQQAMLAQGGMARPPGFYAPPAGMNSYGGGSPAHMVDPYRPNVSASPMVPPGMSMQTGYQQQAYGSPMLGMPATLNGYGYMPPQQYFVPQGQMPHPQGQMNGNGRRGRNNRNNGHGNGYGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M3BZP1</accession>
    <name>M3BZP1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sucrase/ferredoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_148783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761642.1">
        <property type="nucleotide sequence ID" value="XM_016905144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BZP1"/>
    <dbReference type="STRING" id="692275.M3BZP1"/>
    <dbReference type="GeneID" id="27902281"/>
    <dbReference type="eggNOG" id="ENOG502QT0V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033921_0_0_1"/>
    <dbReference type="OMA" id="CTIKYPA"/>
    <dbReference type="OrthoDB" id="10253744at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03062">
        <property type="entry name" value="TRX_Fd_Sucrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009737">
        <property type="entry name" value="Aim32/Apd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902">
        <property type="entry name" value="ACTIN PATCHES DISTAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902:SF14">
        <property type="entry name" value="ACTIN PATCHES DISTAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06999">
        <property type="entry name" value="Suc_Fer-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF13521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="361" mass="39932" checksum="8F5A923D9B30E91A" modified="2013-05-01" version="1">MLRSIYRKVTSGGGDEVLKARSDGFYTAKAIDALFPKTTAEVDGEECLHDCEGCSIKYPKKWSIDEEDKLYGGINGFSRHLIVATGETDWVRAVEDVPGSVMEAVGNHIDKVDGKLMLSASNIPPPTIAGDHIGPYGVDRPTTVLLMPSFTWIENVTPKQVPQLIQSVINTAPTTTTPLDLEPERGSSEEKEMNGNGDVPHTPLPRAPTDLPPGISLRACPHKYVILLCSHATRDARCGQSAPLLRKELERHLRPLGLYRDLHDERPGGVGIYFINHVGGHKYSANMMIYRRAEPSRTVPEQIAGVSKMEEGEAAQCIWLARIRPEDCENVVRYTVMQGKVVKPERQLRGGFDREKGLVSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M3BZT9</accession>
    <name>M3BZT9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_43296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761697.1">
        <property type="nucleotide sequence ID" value="XM_016908891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BZT9"/>
    <dbReference type="GeneID" id="27906028"/>
    <dbReference type="eggNOG" id="ENOG502R9A2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1378904_0_0_1"/>
    <dbReference type="OMA" id="GPENECT"/>
    <dbReference type="OrthoDB" id="3553147at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="44"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF13576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="198" mass="22651" checksum="94CC022609B80BA7" modified="2013-05-01" version="1">MIFQYAQLGTDTIRLIRFHPRSTTSDLHVTLAHQAGYSAQDVHYSVLSHEPISRPSEEQQKAITLNGRTRMLDANAWCALHAVWKDHQDHRQQEDQRFWFEALCVNHNDLFEVEAQRRQLSSIYASADQVLLWMKSDDESIHVEGDLLKRAGIYVLQAKDREALRGAKTVLLLTVEGRRVVEIPSNRLEGPDGPRGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M3C004</accession>
    <name>M3C004_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_148880</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761772.1">
        <property type="nucleotide sequence ID" value="XM_016905202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C004"/>
    <dbReference type="STRING" id="692275.M3C004"/>
    <dbReference type="GeneID" id="27902339"/>
    <dbReference type="eggNOG" id="KOG0191">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021868_0_0_1"/>
    <dbReference type="OMA" id="IFVYFYD"/>
    <dbReference type="OrthoDB" id="72053at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052250">
        <property type="entry name" value="PDI_TMX3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426:SF1">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032069" evidence="7">
        <location>
            <begin position="23"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="656"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="52"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="205"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF13651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="707" mass="79441" checksum="D5D966B211C56281" modified="2013-05-01" version="1">MRASALLSWTATALLAVPPVSAGLFGGNEGNTLGGLMKKDEDTAGKETIFNGRTVPPMIEFEGEKIDEQIKDGYWVVEYFSPYCHHCKAFAPILQTLYEFYYTSDPLPQASGSGETQDDMNSFTRYYDFKFAKVDCVAYGDACVSHEIQSFPTLVLYKDGKMIEKQTGQRDLPTTSKWVEQILEKIKPGSRPQGGPKLPKVGAKEAPAQPAIEASLAKQGDAKVEAGTAKATLTGTRMTEPSKQTPNPVGKSMPLTVDNFQRLVTTTRDPWFIKFYAPWCHHCQAMAPSWQGMAKQMEGRLNVGEVNCETEKRLCKDVKVRGYPTIMFFQGGERIEYEGLRGLGDLMSFANKAVGLTAGIANVTAAEFEEMEAKEEVIFVYFYDDATTSEDFAALERLTLSLIGHAKLVKTRDPAMEERYKISVWPRLIVSRDGKPTYYNALSPRDMRDFRRVLNWMKSVWLPIVPELTASNAREIMDHRLVVLGILSRDRTESFAQSKREIKNAALEWIDKQTQAFQLERQELRDAKQLRIEEAEDRNDQRALRAAKQIRINMDDIERKEVGFAWVDGVFWERWIRTTYGISVGDGEKVIINDEDNHRYWDTTMTGNPIVPSRTSILETLPRIVANPPKISPKSTTNAIGHVWWVIKGNVIHHPFVSLGLLVCVLLVGSIYGRKHFHARGGYIKLDEKAGHMNGLLGGNSGVGKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M3C1E5</accession>
    <name>M3C1E5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_139948</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM234 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762247.1">
        <property type="nucleotide sequence ID" value="XM_016902918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C1E5"/>
    <dbReference type="GeneID" id="27900055"/>
    <dbReference type="eggNOG" id="ENOG502SCJZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108086_3_0_1"/>
    <dbReference type="OMA" id="VIAKETW"/>
    <dbReference type="OrthoDB" id="43458at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018908">
        <property type="entry name" value="TMEM234"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28668">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28668:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10639">
        <property type="entry name" value="TMEM234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF14126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="161" mass="17920" checksum="3AC8DFCDDA185835" modified="2013-05-01" version="1">MDPDSSPTTPPPSPSIWRWVIGFLMVGMCWGLTTPFMRKAAVLRDSQKSQQPHSNSNSNNKNISSWPKRKLLAIWYAVKDLLQNPKYAIPLLLNVTGSVWFFLLIGQAELSLTVPITNSLAFLFTVLGEWWADGKVISRDTWIGMGFVLGGIALCVHSKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M3C1K5</accession>
    <name>M3C1K5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed RNA polymerase III subunit RPC9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_139998</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPC9 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762312.1">
        <property type="nucleotide sequence ID" value="XM_016902919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C1K5"/>
    <dbReference type="STRING" id="692275.M3C1K5"/>
    <dbReference type="GeneID" id="27900056"/>
    <dbReference type="eggNOG" id="ENOG502RM2C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1836403_0_0_1"/>
    <dbReference type="OMA" id="MTERISY"/>
    <dbReference type="OrthoDB" id="10253736at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005574">
        <property type="entry name" value="Rpb4/RPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038324">
        <property type="entry name" value="Rpb4/RPC9_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038846">
        <property type="entry name" value="RPC9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15561">
        <property type="entry name" value="CALCITONIN GENE-RELATED PEPTIDE-RECEPTOR COMPONENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15561:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03874">
        <property type="entry name" value="RNA_pol_Rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF14191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="140" mass="16650" checksum="5379A9DB3829192B" modified="2013-05-01" version="1">MRVLDRTERELKSDKYPYAKNPSAYKDVARSTAFQRFAREAENAMQDSLEAEWKERLQEMTREQIDKEFEPEQEKKCLTEPEMLMIYNHAPETIEMLQPMIEHVEDRFTAEEQQLLVDVIVRTLRPDERPTQSQGNQQGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M3C332</accession>
    <name>M3C332_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_148322</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762807.1">
        <property type="nucleotide sequence ID" value="XM_016904850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C332"/>
    <dbReference type="STRING" id="692275.M3C332"/>
    <dbReference type="GeneID" id="27901987"/>
    <dbReference type="eggNOG" id="KOG2198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005316_4_2_1"/>
    <dbReference type="OMA" id="QLFTEYV"/>
    <dbReference type="OrthoDB" id="6093671at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016428">
        <property type="term" value="F:tRNA (cytidine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057285">
        <property type="entry name" value="Pre-PUA_NSUN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057286">
        <property type="entry name" value="PUA_NSUN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023270">
        <property type="entry name" value="RCMT_NCL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018314">
        <property type="entry name" value="RsmB/NOL1/NOP2-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808">
        <property type="entry name" value="NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808:SF1">
        <property type="entry name" value="RNA CYTOSINE-C(5)-METHYLTRANSFERASE NSUN2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25376">
        <property type="entry name" value="Pre-PUA_NSUN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25378">
        <property type="entry name" value="PUA_NSUN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02011">
        <property type="entry name" value="RCMTNCL1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01153">
        <property type="entry name" value="NOL1_NOP2_SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 10 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="12">
        <location>
            <begin position="68"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="467"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="501"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="819"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="925"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="501"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="556"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="819"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="925"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="351"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="186"/>
            <end position="192"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF14686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="948" mass="104517" checksum="F13366129A1EC8CA" modified="2013-05-01" version="1">MSRTKYRGGARARGRARGGGGGGGGGGSRNQFQDNRVSFDKIEKTNEKFERFYNTIALVPEGPERTAFWTHLRKELPNSWRFTGSKGHALSVRDNLVTRFFPVLRGIKHEGRPVDLPEPIGWYPNGLAYSMTTPKNVVRKYEPFKDFQRFLVSETGVGNISRQEEVSMIPPLLLDVEPHHTVLDLCAAPGSKSAQLVELLHAGEEDRVAKAIEQVKRGEVNGEASEDHGRATGILMANDVNYQRAQMLVHQVKRLNSPNLIVTNHDATMFPSIAMPSGKDGSGNKTGKWLKFDRILADVPCSGDGTCRKNPGIWKDWTPQNGLGLYITQVRILTRALQMLKVGGRVVYSTCSLNPVENEAVIASAIERCGGSSNIRLVDSSDRLPELKRTPGLKDWSIMNRNGTIYESWAEAAGFEQEGSKIVPGMFPPEAEEDIPLENCWRVYPHQQNTGGFFIAALEKLSEVRAKPEDESKSQNRNWTFNKDAVPEKTAFTETMAEIEKGHLDEPKRVDDVPTVTAAPLQNSSTGDAPTVSGAKRAAPEESPESPAKKQRIGEAAAAPDTAMAENGHKVGVTGEVKDAVQEAPFEKTVPPESAHQSKRRGAEANEEAFKYLDSQHPELVGIYNFYELHSAFPRDRFLVRNPAGDPVKGIYYTAELIKQILVSNENRGMKFVHAGVKMFMKQDAQGQDICRWRIQTEGLPIIEGWVGEGRVVTLKKRSTLRKLLVEMFPKVATDKHEDGTETGGWKELGEVGEALNALGGGCCVLRVEATPDAGEDEFKEGLTLPLWRSRASVNLMLPKEDRRAMLLRIYNEDVELINHSDPKQNGGKDFKGEAQSEQEKKKEEAEVQQEPQGSVSGQADAEEVQERIKKADDEDDDEAMGGVAVDQVTGLPATDLGAIALEQDAMTGTDQIETQRLAVMEDEDRKVAEAMPERAGDANADTSNTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M3C3J1</accession>
    <name>M3C3J1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Gfd2/YDR514C-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_132408</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762952.1">
        <property type="nucleotide sequence ID" value="XM_016902492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C3J1"/>
    <dbReference type="STRING" id="692275.M3C3J1"/>
    <dbReference type="GeneID" id="27899629"/>
    <dbReference type="eggNOG" id="ENOG502T6B6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_525965_0_0_1"/>
    <dbReference type="OrthoDB" id="5953249at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040151">
        <property type="entry name" value="Gfd2/YDR514C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048519">
        <property type="entry name" value="Gfd2/YDR514C-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083:SF1">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21762">
        <property type="entry name" value="DEDDh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfd2/YDR514C-like C-terminal" evidence="2">
        <location>
            <begin position="193"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF14831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="518" mass="57057" checksum="25ECD9A35CA707D7" modified="2013-05-01" version="1">MPNPLKKKLQLKRLNSAIQAKAKIKANTSLSSVKNPAVAAAAGGGGRRDDWGSFERSQAKLALRHVSLQPVLSAEHSTRPSKVKVVRMWKLREEARRNKSIEKRKSFDIWRKLFELFSSAAAAITAPFVRRTRPHPFARASVLQTHSPSTVRSRVRRRRARVSSAPNLYYGSIEQLQKILGLDEDASPDRDVIFLALDLEWERKGIRRKITEIGITTLRMSDIVGVEPGAWLRGWKEKMEHVHIVTHACTDASYAMSSSLFAKNSLYMTRSAASAYVQNLVTTLLSSTTTTPPPTPMTSPRIIVVGQSVWTDIVALRYDRSFRLHLPNMLKRKTSSSSSSDSDPSSATTTTNTPNSPFYIFDTHKLALSASASGGQFIGGLRLASIALNLGIEAQYRTPRTDTRQALQDFVHYGSDPLVGMDLKGCHNASNDAAYALMTMLLLGLRWREFVGSDGVRAGKVWEQTGGLVADVGDGGGGGDAGAGGTFGENEKSSKEKKLLSWREWLGQTLRGCFRVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M3C3P3</accession>
    <name>M3C3P3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_59080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF14871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762992.1">
        <property type="nucleotide sequence ID" value="XM_016909483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C3P3"/>
    <dbReference type="STRING" id="692275.M3C3P3"/>
    <dbReference type="GeneID" id="27906620"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_4_1"/>
    <dbReference type="OMA" id="LNHHDLW"/>
    <dbReference type="OrthoDB" id="449487at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05188">
        <property type="entry name" value="MDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000481">
        <property type="entry name" value="Alcohol dehydrogenase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF3">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G13270)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="16"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF14871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="372" mass="39347" checksum="1FA964E29EE5A4C1" modified="2013-05-01" version="1">MPKALVIEKVEGKPGKVYYPLKIIDQPEPQPKDNEVVVKITSAALNHRDLFIRQGLYGAIGFGVPLLADGCGIVIATGNSPQAKNWQGKRVILNPGHGWESDPEGPESSTGYAILGGTTLNPLGTAVEKLVVDAREVEEAPEHLSSNEAAALPLAGLTAWRAVMSKSGSQIQPGRNILITGIGGGVAVMALLFAVAAGANVYVSSGSAEKISLATKKLGAKGGVNYHEKDWDAKLKAMLPLSRPKLDAIIDGAGGDVVQRGVKLLRDGGIISQYGMTTSPKLTWSMPAVLKNLELRGSTMGSRREFSDMVRFVAAKNLRPLVSRAVSCCDGMQNLEGIEGLFEDMKSGKQLGKLVVEISKEGEGDKGNLSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M3C3R8</accession>
    <name>M3C3R8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_105221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF14891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763012.1">
        <property type="nucleotide sequence ID" value="XM_016900569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C3R8"/>
    <dbReference type="GeneID" id="27897706"/>
    <dbReference type="eggNOG" id="ENOG502RA49">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2198641_0_0_1"/>
    <dbReference type="OMA" id="GNKSTHH"/>
    <dbReference type="OrthoDB" id="3646703at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF14891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="108" mass="10913" checksum="25D3C777DC72573F" modified="2013-05-01" version="1">MSTPTTTNNPTGAQGEKAAEEIKGGIKGLNNLSEDIRQNINSFADDLLGGHHNSNSSNSHPSTGFSNDAKAAGKEVERKVGGGGGLATGQPVNDTTTTTTTGTTGKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M3C4X6</accession>
    <name>M3C4X6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_79937</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763462.1">
        <property type="nucleotide sequence ID" value="XM_016910232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C4X6"/>
    <dbReference type="STRING" id="692275.M3C4X6"/>
    <dbReference type="GeneID" id="27907369"/>
    <dbReference type="eggNOG" id="ENOG502S29P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053544_1_0_1"/>
    <dbReference type="OMA" id="TGLFKFE"/>
    <dbReference type="OrthoDB" id="5329385at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031342">
        <property type="entry name" value="Mug163-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17119">
        <property type="entry name" value="MMU163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF15341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="316" mass="35513" checksum="0410FB469E1D9A31" modified="2013-05-01" version="1">MTSNRLQLLRTLLPSRLRANHAHAITITAATPCPEPNVCLNNSCRCFARVNDVDPWSRDIWFTSAAPRHLASDLPPSSDYKPPDERTVKLGRTVRLLHERLPTLLKEPLPSETLSPSITLHLFPSTHPHLPTVSGRLGYIAALWTAPVAWGRMPLIGNVRLEILAERMIQNGGTAVPLAQREEKLVVKWKTCGKTTHRDGTGGIYRGMGLAAKDPVEKIRGFIAGTRQGSQADEEPEEFRGIFIFEFDEEGRISKHTIEHAEEGGHWDRTARVVSVTDWLLGHLNGKRRYDEPALALCEERPHCRGIRLVDRREPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M3C5S5</accession>
    <name>M3C5S5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Translocation protein SEC62</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_147456</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SEC62 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763747.1">
        <property type="nucleotide sequence ID" value="XM_016904311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C5S5"/>
    <dbReference type="STRING" id="692275.M3C5S5"/>
    <dbReference type="GeneID" id="27901448"/>
    <dbReference type="eggNOG" id="KOG2927">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040936_0_0_1"/>
    <dbReference type="OMA" id="WGWQETK"/>
    <dbReference type="OrthoDB" id="200187at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004728">
        <property type="entry name" value="Sec62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011553">
        <property type="entry name" value="Sec62_asco"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00869">
        <property type="entry name" value="sec62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12443">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12443:SF9">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03839">
        <property type="entry name" value="Sec62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="290"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="86"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="359"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="86"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="413"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF15626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="444" mass="49899" checksum="141F1059BBEF2C00" modified="2013-05-01" version="1">MYHHNIVGGPPPGPQVEEQPPQAQAQPAAEAPPIQPPQAPFQLQPGQQPTPEQIQMMQQQLAAEAQKHGLTVPQYIERVKAQMMQQAQMQQRMQQQQQQQQGGGPHDEHQHRQGPQGAQPGKQVPIQPGPPKPEAIAMAAFLQSQDLKLRTCIFNEQRKDMFKVKRAIRAIQSDAYVKARKKNPLLPEVTDRVQAENAFKLLPLSLLALRCSKVDEHAGHEGHGHAKKKRVKGLWTVKVEPQQEAADEYYYVWLYQSPASQWKSKLYAAGALVGILAIVFFPVWPYTLRIGVWYVSMGMLGLLGLFFAMAIFRLILFLATFFTVSPGLWLYPNLFEDVGFFDSFRPVWAWHESEKDMKKRKKDERAAKKARREARARGELPPSSKKSKQKQIEDKAQPAVPVPAKGIVEAADTATTGAESTQAGGLQQRIIQPRVASVEEEEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M3C816</accession>
    <name>M3C816_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_121544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF08035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756156.1">
        <property type="nucleotide sequence ID" value="XM_016901692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C816"/>
    <dbReference type="GeneID" id="27898829"/>
    <dbReference type="HOGENOM" id="CLU_2224836_0_0_1"/>
    <dbReference type="OrthoDB" id="5945798at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF08035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="106" mass="11612" checksum="D5EF4080682DEA04" modified="2013-05-01" version="1">MTWRKAANAAVADADVHAHGDVQRKCMSWQDAVKAGTQRAATTAPSSSRRRVIVNDPRELLMSWQEAVRTGPSREPRSAPWSRSGSFSNLLKPSSLRVHGRSKTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M3C8M5</accession>
    <name>M3C8M5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Core Histone H2A/H2B/H3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_54683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF08240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="52" mass="5819" checksum="4726797796B8C36F" modified="2013-05-01" version="1" fragment="single">LRIQASALGVLQEYAKSLLVRIFTSANLLAIYAKRVTLQGKDIECLRSLLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-05-03" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M3CCE4</accession>
    <name>M3CCE4_SPHMS</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_119785</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
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        <lineage>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="27898680"/>
    <dbReference type="HOGENOM" id="CLU_1876725_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032664" evidence="1">
        <location>
            <begin position="22"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF10057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="132" mass="14192" checksum="9CC9342DF2A5C89D" modified="2013-05-01" version="1">MSSPIITSILTFFLIVSPSLSFTPKPRCGSCDGSAQLFSSNDCSNPIQGTYQEWGNSDESNAPLPCTTISGSNPLSLNKTMSGNRCSLIVYSDEECKHFLDASSISWSGCANINGGAQSWEIFCTPRTEPFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M3CCW4</accession>
    <name>M3CCW4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_158390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016907789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CCW4"/>
    <dbReference type="STRING" id="692275.M3CCW4"/>
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    <dbReference type="eggNOG" id="ENOG502RGHC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_874841_0_0_1"/>
    <dbReference type="OrthoDB" id="3639988at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF10257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="318" mass="36051" checksum="5B8B86646CF8CCB1" modified="2013-05-01" version="1">MAMRRSGKASAAAARKDPDDDDGDDDDDGDDDEDDDDDEDDEDDDDDDDDGESNDDGERGPAAWGVRQRVMAIHLIYEPSQHSLSEFMREDLPERSEHSALYRRQVLAISGLVRTQADLVTLNTPVPCQGPAWSKQMVEQMRKRWHNIRDQYTAYIAYCRNPQLPRQGTDVEGTILSIQQLLYAVQDTLIQFTSMADGASLQMLDLLREVLLHLRYWRHDARPANAPSYAGGSQNFEYNLLFRFAGFPSNWRSCVDVVGVLGEKYGAHFKRREKEWQSAYYELYKALAPYPGDTGAFVGAFHGRLSEVGEIKADEELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M3CD17</accession>
    <name>M3CD17_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_151288</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758428.1">
        <property type="nucleotide sequence ID" value="XM_016906720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CD17"/>
    <dbReference type="STRING" id="692275.M3CD17"/>
    <dbReference type="GeneID" id="27903857"/>
    <dbReference type="eggNOG" id="ENOG502RFVR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_848753_0_0_1"/>
    <dbReference type="OMA" id="WTIIFAY"/>
    <dbReference type="OrthoDB" id="3942482at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF10307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="324" mass="33995" checksum="9962F93E5E92CAEC" modified="2013-05-01" version="1">MTFSSCFEKKMNEHMHDDGQPERAPSEFEDTDMAMKKKGLSSPQFDDDEFNEKRRSQPPRFSTIFGTGSTPPPPPPPRQHFQEYYPEARKKSGVHLSMPVFIFFVAILFFSWTIIFAYTIIGLYNNAPARLFPWAGQGAARMAAACDCNTVPPQTQPNVNIAPNFVVPHQANSSPQMITITASPITVTATPSTVTATPSTITITPSTSSTTTSSSTASSSSTNNPAPAIASEIAAILGSISKTTSESIAIVTASATRSTVTSVKLITQDASGNVISATPAPTVTLTTVVDPPAASGSGGGSGAGTSAATKTTMEPIVIVPTTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>M3CEU0</accession>
    <name>M3CEU0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_150461</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759682.1">
        <property type="nucleotide sequence ID" value="XM_016906191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CEU0"/>
    <dbReference type="GeneID" id="27903328"/>
    <dbReference type="HOGENOM" id="CLU_2499303_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF11561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="86" mass="9801" checksum="50DD87CFEF52C030" modified="2013-05-01" version="1">MDNDWVELGCRRSLKGNEDLDTTPCTRLGDWRGVSIRNLRAVQFPCQADDHLHTLLASEKHDITLGEATDFAIDTLRKCWARQCAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M3CF16</accession>
    <name>M3CF16_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_163547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760509.1">
        <property type="nucleotide sequence ID" value="XM_016908066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CF16"/>
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    <dbReference type="eggNOG" id="ENOG502S7XT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092846_0_0_1"/>
    <dbReference type="OMA" id="QPGPAIM"/>
    <dbReference type="OrthoDB" id="2530523at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF12388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="315" mass="33361" checksum="1388AD637329ABEF" modified="2013-05-01" version="1" fragment="single">MASELAYGSTHGGVAYPSLNHYYPHAAAVGGSAAASAASAAAAPANSAQQAFSPGTTNHYNPHQHQQQQQHGHGAAGVSSGGSMEHHHQHQQQPQHVGNGFHFTSGPPPSRLAHQFHHQQPSVRNSTSPQPGAAHQPTPPKQYPMAAPPLPNTPNSVSNSNTGASPGSPRSPGTETREQQRTALLFDINNELLKEVNNLQLAGKGGAMSPQQVQQARSEGKSDHMASEEYIQSLRRLQANLAYLMAKAQPDAAAQQQQQQSQQSGKPAPGPAHMTAPPHMPQLEDSYRTLRDLFPGWQGLDHRSSSSMSGPPPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M3CFD4</accession>
    <name>M3CFD4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_149179</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760654.1">
        <property type="nucleotide sequence ID" value="XM_016905391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CFD4"/>
    <dbReference type="GeneID" id="27902528"/>
    <dbReference type="HOGENOM" id="CLU_1462202_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF12533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="185" mass="20956" checksum="34B54A865B0B3D7A" modified="2013-05-01" version="1">MVLAKQPMEGTHLVERMLHSDVSETPHPSGPPRLPLHHRGVWMLVSVIWSLKYLHLQPLPPIAATCDNANITVRFSYELAQKVHAIFLVPILCAFVLWLCCMCRRGLAGMAGHVRARLQARNPALPCTASHFRSQARQQRRRATRTYGNGSVSVPSGKRRDCQDDLDLLQVRPRQQLGELHLHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M3CFD7</accession>
    <name>M3CFD7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_44535</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760659.1">
        <property type="nucleotide sequence ID" value="XM_016908935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CFD7"/>
    <dbReference type="STRING" id="692275.M3CFD7"/>
    <dbReference type="GeneID" id="27906072"/>
    <dbReference type="eggNOG" id="KOG2551">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051938_3_1_1"/>
    <dbReference type="OMA" id="DYACGLE"/>
    <dbReference type="OrthoDB" id="2094269at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF6">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="3">
        <location>
            <begin position="6"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="289"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="296"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF12538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="337" mass="37746" checksum="EEB91E8E84E1C4A7" modified="2013-05-01" version="1">MSRRDRKMRVLCLHGFGQSGEFFRTKMKRITQYLERNLDSDLQADYSDGMEWMFPDAPIELTTDSPQSDILEMRAWWTRLEFTIRLDQLYSSLDYLTKYIREHGPFDGIVGFSQGASIAMMLASLCEGSVRPERVMALANQGLPLLIPPPQSPFKFAIACSGFVNAPQFYDGFFTPQVQTPTMHLIAEWDHMVSEQMSGEMIKRCENPVVVKHAGTHAVPTDRNSMWEMSRFLNQTCIKAALTERSLAAEGQPLRRSSLLVTSATLTVTAVTNVAMSVASGCEVEHLPALTEGSISPKSSRTTSPGSSESGDTGVTGVMQKRRKKLRFARKITIKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M3CME0</accession>
    <name>M3CME0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_130740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF14963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763084.1">
        <property type="nucleotide sequence ID" value="XM_016902371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CME0"/>
    <dbReference type="GeneID" id="27899508"/>
    <dbReference type="HOGENOM" id="CLU_1307514_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF14963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="211" mass="23590" checksum="38E51F34AA94F68D" modified="2013-05-01" version="1" fragment="single">MALYELSMCPRHQSLRISGSNNSHVRKRDDDKTYTANDKRRMMDDTGWSLSHWTELFRSRNNYNAYRPPDIALQLGENYHHLHHQRCRGSSSVLSYSAVAVSIFHFSRSSPISFVQLVVLGLCHVLYCLCSHTCCTGIVMNTDLLIHTGPTIIGKGIGVLVIHICCTFIGKGIGVLILPLILAHAFGCIASLSKANGLEQERRISFNISFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M3CMT4</accession>
    <name>M3CMT4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Adenine deaminase</fullName>
            <shortName evidence="7">ADE</shortName>
            <ecNumber evidence="7">3.5.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Adenine aminohydrolase</fullName>
            <shortName evidence="7">AAH</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">AAH1</name>
        <name evidence="9" type="ORF">SEPMUDRAFT_147089</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>adenine + H2O + H(+) = hypoxanthine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:23688"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.2" evidence="7"/>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763244.1">
        <property type="nucleotide sequence ID" value="XM_016904073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CMT4"/>
    <dbReference type="STRING" id="692275.M3CMT4"/>
    <dbReference type="GeneID" id="27901210"/>
    <dbReference type="eggNOG" id="KOG1097">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039228_7_0_1"/>
    <dbReference type="OMA" id="NHFTIHA"/>
    <dbReference type="OrthoDB" id="272271at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000034">
        <property type="term" value="F:adenine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006146">
        <property type="term" value="P:adenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043103">
        <property type="term" value="P:hypoxanthine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009168">
        <property type="term" value="P:purine ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01320">
        <property type="entry name" value="ADA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000039">
        <property type="entry name" value="Adenine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01962">
        <property type="entry name" value="Adenine_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006650">
        <property type="entry name" value="A/AMP_deam_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028892">
        <property type="entry name" value="ADE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01430">
        <property type="entry name" value="aden_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43114">
        <property type="entry name" value="ADENINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43114:SF6">
        <property type="entry name" value="ADENINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00485">
        <property type="entry name" value="A_DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="8">
        <location>
            <begin position="14"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="7">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF15123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="356" mass="39920" checksum="00A939F03CE634B2" modified="2013-05-01" version="1">MCKPEFRSFLKSLPKCEHHMHLEGALTPHMLFKLAANKISLPAEDPAFASPETLLKRYNEFTSLDDFLHYYYIGMSVLVTASDFESLAWDYFEHASADGVAHAEVFFDPQAHLSRGVSYDTVLTGFNAARKRASIELGITSELICCFLRHVPVPECLATFDLPEVQASYQRGDIIGIGLDSSEMNFPPEMFQNMYQGAKELGLRRTAHAGEEGPPEYIRNSLDRLDVQRIDHGIRLAEDPELLARVASAGTLLTVCPMSNVLLRCVTEVAEVPIRKFLDAGVKFSINSDDPAYFGNNYILDNYVAVQDAFELTVAEWKQICQNSIEGSWCQQARKDEMLSQLEQVISNWEAATAHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M3CQW1</accession>
    <name>M3CQW1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Syja_N-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_147740</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF16063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764184.1">
        <property type="nucleotide sequence ID" value="XM_016904494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CQW1"/>
    <dbReference type="STRING" id="692275.M3CQW1"/>
    <dbReference type="GeneID" id="27901631"/>
    <dbReference type="eggNOG" id="KOG1890">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006249_1_0_1"/>
    <dbReference type="OMA" id="YFWNRHL"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043812">
        <property type="term" value="F:phosphatidylinositol-4-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034753">
        <property type="entry name" value="hSac2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022158">
        <property type="entry name" value="Inositol_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662:SF7">
        <property type="entry name" value="SACI DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G15890)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12456">
        <property type="entry name" value="hSac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51791">
        <property type="entry name" value="HSAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032033" evidence="2">
        <location>
            <begin position="24"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="domain" description="SAC" evidence="3">
        <location>
            <begin position="254"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="HSac2" evidence="4">
        <location>
            <begin position="683"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="803"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="822"/>
            <end position="839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF16063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="944" mass="104655" checksum="EA166A27B92DCA51" modified="2013-05-01" version="1">MPGLARKLLVFAAVDGLFVQAAGQRVAEDRNAGVRIAYGGSNTITTAREQNETLEGASLEAHGIVGLLNLVSQSYLVTITKRQQVAHIRERPVFRITDVSLIPLSSRAEAATAISEAQKRLRPGSGSDEGEDDETSTIGTEPGEQAQEHYPENGADALEPSKEDTVRKNTMQDVIQTKGKFARYATSWFGKTGTPANSKSSESGKTIPQEQARQEGEDQLDVRERVEDVQSRSSTEKRRQTAVDFLAPRILRNARLYFSSSGFYFSYDHDLSHALGRAPQVSSSMPMWKRFDNLFFWNQHLIKPFSHAGQDSLVLPLIQGFVGQRAFSIMLANDQSVLTEADGTELTDFSQSETAKDAINHDFLLTLISRRSVKRAGLRYLRRGIDDQGNVANSVETEQILSGQVNDSTEKLFSLLQYRGSMPLFFSQSPYSFKPAPVLFGSEATNQAAFRKHFQSLVDRYGDMQAASLVDKHGTEVGIGAVYENMANTLNEKGGINGKSIGFEWFDFHGECKGMKFENVSILMHTLDKFLTSSGCTIEQDGKVEQKQSGVLRTNCMDCLDRTNVTQSAVGAWALQQQLAQLGLDIDLESDPKTQWFNTLWADNGDAISKQYAGTSALKADFTRTRKRNWAGALSDLSLTINRYYNNIFGDYFLQANIDYFLGALPSVFEEFETNMTTQDYALDMNVIRQNAIDTSEKIVLGDDENLISAWTLSSPRRANTLRSLPFEECVVLLTDEALYHVRFDWNTDKVGSFEKICLLDIREIWRGPYITSALGPIHLDPSKNYGFALRYTCGSSSLVPTNTRTLGTSPDDAEAASEGEGVEHESIEQKHIADDSNRGNHTVPKVGDTRMLAFKALPPGHMKADTKADNRANLGSVEAVVRITEELQKAIRGARKVDSGGSSEETKDEFHVQEHDIISAAEAKKSTSYVESLGYTLKKLVWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M3CUW1</accession>
    <name>M3CUW1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_111988</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF07932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756053.1">
        <property type="nucleotide sequence ID" value="XM_016900951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CUW1"/>
    <dbReference type="GeneID" id="27898088"/>
    <dbReference type="eggNOG" id="KOG2615">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_54_6_1"/>
    <dbReference type="OMA" id="IWQMILF"/>
    <dbReference type="OrthoDB" id="419616at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17330">
        <property type="entry name" value="MFS_SLC46_TetA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="385"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="415"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="452"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="489"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="86"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="42"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="515"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="516"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF07932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="534" mass="57569" checksum="910C755870E53130" modified="2013-05-01" version="1">MAPSPDVSRSDTIDAASSEATPLLGNPESSRLLTNYAATASITTNGDTSTNSSSKSPPQLLSKNATLSSLPSKQKSDSAQPMPYKQVLILCYASLAEPVAYFAIFPFINEMLSRNGNLPEEDVGFWSGTIESLFSLVQMVLMIFYGRMADRVGRKPILVFSLTGVSIATALFGLSKTLWQMIFFRCLAGVFAGSVVTVRTMLSEITTKETQGRAFSWYMFTRNMGILVGPLIGGALANPATQYPGAFGKVQFLVDYPYALATFVAGVICLSGTLCSLFFLKETLNRKPSASTSTTQPPEPPMSTLQVLRSPGVGLVLYILAHTMTLALGYTAVMPVVMYEPVEKSGFGFSPAYISYSLATVGAAQALWILLVFPPLQKRVGSRRVLLWCAILWPFFMAAYPILNEFLRAGWQTAFWIVTPIMLVLGSGVSMAFAAVQLLINDISPRPEVLGTVNALSLTVNSGVRAVAPALFTSIYAIGIKLGWADGHLVWFVIVPIAALLYVAASFLPLEEMRDDDAPVKGDGRAGDEDEGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M3CXQ1</accession>
    <name>M3CXQ1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_73098</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756988.1">
        <property type="nucleotide sequence ID" value="XM_016910011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CXQ1"/>
    <dbReference type="STRING" id="692275.M3CXQ1"/>
    <dbReference type="GeneID" id="27907148"/>
    <dbReference type="eggNOG" id="KOG0922">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001832_5_11_1"/>
    <dbReference type="OMA" id="APVHDFV"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000145">
        <property type="entry name" value="probable ATP-dependent RNA helicase DHX40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF118">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="56"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="262"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF08867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="703" mass="79338" checksum="71664CD8853AAEC4" modified="2013-05-01" version="1">MSRFKNLDGSIEARPDPQKRKRDWDEVHQPYLAKKQKLHQGRLQLPIWPRAKEIRACLSGTQDVLILTGETGSGKSTQVPQFLQEASWCSGKIAVTQPRRVAAISLARRVAEEMGSPLGSSSRLSKVGYSVRFDDNTSESTRIKYLTEGMLLQEMLRDPKLKQYSCVVVDEVHERSVDVDLILGFLKGLVRERRRKGKVLKVVVMSATADVESLREFFARDGIQDREVAQSDRVALCHVEGRQYPVKLQYTSSPAEDVIDAALQRIFQIHCKEPMPGDILVFLTGQEAITGLQRLIEEFASNLTADFPKLVVLPLYAALPQQAQQRIFERAPPNTRKVILSTNIAETSVTVPGVRFVVDTGKAKIKQFRPRLGIESLLIKPISRSSADQRKGRAGREGPGQCFRLFTEADYKSLEQNTRPEILHCDLTGAALKMKARGIDDVFGFPFLTPPSQQAMGSSLIQLHQLGCIDDAGKITEVGLKVARLPLPPPLGRVIFESTRPDRDCLLEVIDIVAALDVESIWLPADTEEAREKAQEARSQLFSRKGDHITLLNAVRGYVEEHTDRKRWSTDRMISHRSMQNVMDVRKQLQIQTKDLLEGKKQQQQQQSPTVRETISEECQDAILKCFLRGFSSNVARLCPDKTYKTFVNNNQTVAIHPSSTLYGAKREAIMFNDFTFTTKPWARKVSAIELKWLEEVDYLMQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M3CXT9</accession>
    <name>M3CXT9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_151802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757013.1">
        <property type="nucleotide sequence ID" value="XM_016907054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CXT9"/>
    <dbReference type="GeneID" id="27904191"/>
    <dbReference type="eggNOG" id="ENOG502SZ4D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1796425_0_0_1"/>
    <dbReference type="OMA" id="RVHQFRH"/>
    <dbReference type="OrthoDB" id="4138121at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF08892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="171" mass="18853" checksum="85059FAEBB2ECB53" modified="2013-05-01" version="1">MAPWLRVLEAYAVEALLRTPAFHRGVEKVAKQVHRIRHGLPHEEPGGTNISDSSKPGFGKHFIEELKGQLGQAERRELEEAAMKKRTDGIDARGAVSDADTQRAERVWQSMQSAKSGHTGQARKSTAQEQADADAAWRETQARLNEKPKAGFLGAYIDAIKEQIGNGKSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M3CY11</accession>
    <name>M3CY11_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Rtt106-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_152197</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Histones H3 and H4 chaperone involved in the nucleosome formation and heterochromatin silencing. Required for the deposition of H3K56ac-carrying H3-H4 complex onto newly-replicated DNA. Plays a role in the transcriptional regulation of the cell-cycle dependent histone genes by creating a repressive structure at the core histone gene promoter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with histones H3 and H4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RTT106 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756692.1">
        <property type="nucleotide sequence ID" value="XM_016907296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CY11"/>
    <dbReference type="STRING" id="692275.M3CY11"/>
    <dbReference type="GeneID" id="27904433"/>
    <dbReference type="eggNOG" id="ENOG502R9PE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033828_0_0_1"/>
    <dbReference type="OMA" id="AMPEAHR"/>
    <dbReference type="OrthoDB" id="75754at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050454">
        <property type="entry name" value="RTT106/SSRP1_HistChap/FACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040770">
        <property type="entry name" value="Rtt106_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849:SF3">
        <property type="entry name" value="HISTONE CHAPERONE RTT106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18469">
        <property type="entry name" value="PH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone chaperone RTT106/FACT complex subunit SPT16-like middle" evidence="12">
        <location>
            <begin position="240"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="48"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="343"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="343"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="382"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="400"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF08571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="430" mass="47306" checksum="83F091A1AD844241" modified="2013-05-01" version="1">MADWTHEVQATFQSDTDLTARILAAGTRYQGELPALFADIARHVQTGSSILPPTSKKRKLDDALQPPPPTTNGASHAAPIIAPSTTFECKNVSFQVPARKKLKLQIVAEQADARRREVRLLNAQTNDVEYTIPNAKIDQVFCLPVPEKQQRQSSFVIIPLAGAIGPDGTTCEQMVFTMNETKPDDAVSSVRPKAEDDTYITVMEPELNDLLEPHGKRVVRPDENEFASSIPQPHRKGEKAYHVKAHRGTKEGYLFFLPNGIVFGFKKPLSFFPFSSVESISYTSVLQRTFNLVITATEGGSTEAKDVEFSMIDQADFAGIDEYVKRHGLNDASMAADRRAKAYNVNKEKKEANGDTNGSAETGAVDDDGLTELQRAEQQLQDQEDEEEEDYVESGGETDGSGEDSGEDEDAEDYGEGEGGYDEDDGDEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M3CYF3</accession>
    <name>M3CYF3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_151938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF09107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757228.1">
        <property type="nucleotide sequence ID" value="XM_016907138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CYF3"/>
    <dbReference type="STRING" id="692275.M3CYF3"/>
    <dbReference type="GeneID" id="27904275"/>
    <dbReference type="eggNOG" id="ENOG502S90D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096188_0_1_1"/>
    <dbReference type="OMA" id="NWARMLY"/>
    <dbReference type="OrthoDB" id="5840532at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02231">
        <property type="entry name" value="cupin_BLL6423-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047142">
        <property type="entry name" value="OryJ/VirC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36156:SF2">
        <property type="entry name" value="CUPIN TYPE-2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36156">
        <property type="entry name" value="SLR2101 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="1">
        <location>
            <begin position="87"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="184" mass="19842" checksum="F72628D6CAA7F51D" modified="2013-05-01" version="1">MAPSERLPAPTVIKTTHDKDGKSIVNKSVPEHPNEQVVTNGDAVFYLGYATEQFPVEMNNDTDLKAYEKLESSPPGLTISGGTVLRYVDLKPGCTSAMHRTISLDYGIVIAGQLELVLDSGETRILGPGDICVQRGTMHAWKNPSDTTWARVVFVLVPSKPLEVNGQKLGEDYGGNMAGVRASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M3CYI2</accession>
    <name>M3CYI2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_128635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF09137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757258.1">
        <property type="nucleotide sequence ID" value="XM_016902224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CYI2"/>
    <dbReference type="STRING" id="692275.M3CYI2"/>
    <dbReference type="GeneID" id="27899361"/>
    <dbReference type="HOGENOM" id="CLU_2723829_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21134">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007275">
        <property type="entry name" value="YTH_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04146">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50882">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YTH" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="72" mass="8091" checksum="3223AC7202DE5361" modified="2013-05-01" version="1">MNAVVATPFRVTWCRRRAVSFQQVRGLRNEWNGGKEVKVARDGTELEPAVAKRILQLIHAPMMQEVVGGPAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M3D057</accession>
    <name>M3D057_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_158106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF09868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757989.1">
        <property type="nucleotide sequence ID" value="XM_016907769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D057"/>
    <dbReference type="GeneID" id="27904906"/>
    <dbReference type="HOGENOM" id="CLU_1295125_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="213" mass="23583" checksum="FF214E6D6CF78DB3" modified="2013-05-01" version="1">MAGPPLRRYLREPTSTRCLVLSPALSREPDSKPDSTVQASESGRKGKGKRSLTQAAQSDVPLPRPRAFPTRGERARFPPRREEAAAEAFVQLFGEQPAVSPPLDDDQATEVNSEVAFLEAQEPEIDLSVDQRHWYVIAREHAALEGRIMTDNLLRAGERAYAELLGRVPTEAQSVEAWLHGTHGAGDAEVRRARYQILYDEELQGVDSEGTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M3D068</accession>
    <name>M3D068_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ER membrane protein complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_158113</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the EMC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF09878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757999.1">
        <property type="nucleotide sequence ID" value="XM_016907770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D068"/>
    <dbReference type="STRING" id="692275.M3D068"/>
    <dbReference type="GeneID" id="27904907"/>
    <dbReference type="eggNOG" id="KOG3060">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052388_0_0_1"/>
    <dbReference type="OMA" id="LMEMLFY"/>
    <dbReference type="OrthoDB" id="124397at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039856">
        <property type="entry name" value="EMC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055217">
        <property type="entry name" value="TPR_EMC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12760">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22890">
        <property type="entry name" value="TPR_EMC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EMC2 TPR-like" evidence="5">
        <location>
            <begin position="108"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="161"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF09878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="333" mass="36826" checksum="51F6DD371734FF40" modified="2013-05-01" version="1">MSTSLLQPPTNSNPETALSQSANAEAFFKSQKSWYPALPYPLSLFSNSESQEKWTTYENLFLSCLRTGQNDSAHLCLEELTTRFGLTNERVAALRGLWAEATATNPQELEDVMAHYEEILKEDPACFAIRKRRAALLKSMGKTSEAIAALVNLVDTNPTDAEAWSELAEMYVQQGMWERGKFCLEEVLLLAPNAWNLHARMGEVTFLSASGLQAGSGEQLKVLSEAMRRFCRAVELCDDYLRGYYGLKVSTTRLLEVLATTKKGQLTTSDSQAGDLAPPSIETVKKLNELATAKLAEIVRRSKSGEKGWDGYNAAEIAAARALLDKDVQKIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M3D0K7</accession>
    <name>M3D0K7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_165705</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF09998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758119.1">
        <property type="nucleotide sequence ID" value="XM_016908185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D0K7"/>
    <dbReference type="STRING" id="692275.M3D0K7"/>
    <dbReference type="GeneID" id="27905322"/>
    <dbReference type="eggNOG" id="ENOG502RV4Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_370461_0_0_1"/>
    <dbReference type="OMA" id="NRIGCPM"/>
    <dbReference type="OrthoDB" id="2943660at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004330">
        <property type="entry name" value="FAR1_DNA_bnd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF32">
        <property type="entry name" value="ARGININE METABOLISM REGULATION PROTEIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03101">
        <property type="entry name" value="FAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="378"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="410"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="360"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="430"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="447"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="469"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF09998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="771" mass="85819" checksum="15D240862B52F87D" modified="2013-05-01" version="1">MNGHHNNHHSQQFPRFSAQPNAYVYNTTPYQTPSLHYPYSTPSLSQQQQQQQQQQQQQPPPSSFFPSLQQTSPATGNHHPPAPAPARHTPQSAPNLRQVHHNRSSPLPSSPGNGPGAPPPERHSPTFEDDLLNALQNSGEQGHRSHPTNDDDEDDEDGDDDDDDQDVVDGDEPVYQLPPPPETQYPNEVELEKAIHAWSLEHGYELVRRASKRNAKGQLYKRYYHCSRHGRRASARTPDKDKVRINRKSNRIGCPMSLAAVSVNPHDPSGNWQIRLRKTHHNHPAVNAAELAGHRRRARLGAVEKAVDGLFAINTSTQDVLKFLQRTHAEGLFKRTDVANMKLKWKKYGSCAHQAEGGQSEVTPQSTPTTMQRGIPSACRTCRVKKTKCDSQRPTCGTCVKSGSACQYDPPARTGQQQQPLPPAPPNRIVQPQSTPSNSALRREAQRQATAGAAGADSMQIDSTPLDFNLSNQVNDANANNTPGQKASQTAQTQQMLAAIAAFQQEHIKPTRLELSSSAVEVLAASTCGSGDSYRSAIPHPFSMLGDWKQFREAFESAAVKENCVDVLRGHKREPEKPEPADGQRVIEVEVHNEYVKQLAIFKRRNEMLKLGFRETLAPALWSRLKSLSDAHEIWVALGDMCCPRGSDQAYTRFRSILDVTFQACGNHLDNYIQTLELMWGEFNEMAHTHESRRATSQLNMSAAEVLKRKIAGNGTFPEEMLCFLFLKNLGPQHQALATNMCKKNNIGGFGTGERCGFKDLWTQVKKALER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M3D1A6</accession>
    <name>M3D1A6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_150243</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759389.1">
        <property type="nucleotide sequence ID" value="XM_016906042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D1A6"/>
    <dbReference type="GeneID" id="27903179"/>
    <dbReference type="eggNOG" id="ENOG502SR0R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095762_0_0_1"/>
    <dbReference type="OMA" id="HKANMLS"/>
    <dbReference type="OrthoDB" id="3942453at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF11268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="208" mass="22912" checksum="5E1158BABB40784B" modified="2013-05-01" version="1">MCIAGLNLTTRTCAHRWYELIRQCNPANSLHNCPEKLRLEGWERQRADCPFCDGTGHDHSTHRLFGSTSSASSVTSSPTMSAMGSFHDRYSRRSSGATATTGIASALSRQNSNYSSSCSGELDRAIQARHMNRRIHVYLSSDPHEILPSATKNYPTYAAAIAKAESSAAGGRSEAKRLRRSNSFAVVSRGWQRMSKRLSINPDLFKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M3D277</accession>
    <name>M3D277_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_164775</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759353.1">
        <property type="nucleotide sequence ID" value="XM_016908133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D277"/>
    <dbReference type="GeneID" id="27905270"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_1_1_1"/>
    <dbReference type="OMA" id="CIYFNTW"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF234">
        <property type="entry name" value="MFS-TYPE TRANSPORTER DBAD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF11232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="419" mass="44484" checksum="4025BD1F4EF2121E" modified="2013-05-01" version="1">MSSSQDEGSEKARPGPDAPVEIQKDSGFQAWSQVLGAWCLYFNTWGLLASFGSFQAFYESDLLASESSFAISTVGSLQSFLLVFLGFFAGPLYDAGYSRHLLSIGSLLIVAGTVAQSFCTELWQLEVAQGVCIGIGCGCLGVLSVAIPSLWFTYRLPLANGIAASGSGFGGVVLPIMIRNLINQVGFGWTVRAIALVQLVLLSSANLLLRVPQKPKNRRRLLDLASLKDWPYIFFVLACFVVFLGMFTPFFYVQSFAIESGIASENVGFYIVPAMNAGSIPGRILPALLAQYLGPLNMIIGATVALGACGFGFLGTNALASVYVVAIMYGFFSGLFFAMQPTIFVRLTSDMAVVGTRFGMAFTVMSVALLFGSPIGGAVQGPGGYDASWIYVGVAAFAGSAVMCTARVLKVGWAPLARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M3D3F2</accession>
    <name>M3D3F2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Redoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_117006</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peroxiredoxin family. Prx5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760535.1">
        <property type="nucleotide sequence ID" value="XM_016901300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D3F2"/>
    <dbReference type="STRING" id="692275.M3D3F2"/>
    <dbReference type="GeneID" id="27898437"/>
    <dbReference type="eggNOG" id="KOG0541">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072440_3_0_1"/>
    <dbReference type="OMA" id="SAWGKQH"/>
    <dbReference type="OrthoDB" id="1882547at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03013">
        <property type="entry name" value="PRX5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000159">
        <property type="entry name" value="Peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037944">
        <property type="entry name" value="PRX5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430">
        <property type="entry name" value="PEROXIREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430:SF39">
        <property type="entry name" value="PEROXISOMAL MEMBRANE ASSOCIATED PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 7" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5 7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="2"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="6">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR637944-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF12414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="155" mass="16098" checksum="9C675A0E6E90B374" modified="2013-05-01" version="1">MVKAGDSIPNVELVEGAPDKKVNLAKELATGKGVIVGVPAAFSPTCSASHVPGYIANKNLANAGKVFVVSVNDPFVMKAWGESLDPGAKSGIRFLGDPHSELTKAWDLEFDSAAIFGQNRGKRCAIVTEDGKVTAVHLEPDNVGVSVSAAEKVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M3D3Z7</accession>
    <name>M3D3Z7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Inheritance of peroxisomes protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_149445</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for peroxisome inheritance.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the INP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761026.1">
        <property type="nucleotide sequence ID" value="XM_016905554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D3Z7"/>
    <dbReference type="STRING" id="692275.M3D3Z7"/>
    <dbReference type="GeneID" id="27902691"/>
    <dbReference type="eggNOG" id="ENOG502S7ZC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016546_1_1_1"/>
    <dbReference type="OMA" id="RTACPFA"/>
    <dbReference type="OrthoDB" id="4097008at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005780">
        <property type="term" value="C:extrinsic component of intraperoxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045033">
        <property type="term" value="P:peroxisome inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024758">
        <property type="entry name" value="Inp1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12634">
        <property type="entry name" value="Inp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="57"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="195"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="581"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="670"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="761"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="207"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="295"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="355"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="398"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="449"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="500"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="511"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="585"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="684"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="767"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="811"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF12905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="829" mass="88623" checksum="D2F586D7D5CB5CCD" modified="2013-05-01" version="1">MSTPVPRTPDQTSRNVALNRSFSAAHAPNRAQPIADIGATEGVETLFSHASGKIVKFTSNAPTRPNSSGQSGTWSPGGGGGLHQPGTLPWATLTEKTMAAGPLEIYRVPGSVSFLHSGSLLHAIMPRSNCWCVDGVSKFAMRVLPDTYYRIELPGNTPEDLAKVEEFKITLQKVLFYERTACPFARTFQVDLPIEGEPKPRKKRRRTDGPAKKWKLDKAYSWKPEGWTPEQDAPSDGSSGSGTTSDEEGSSGSPEELADGLAEHVAELSVNRPAPARKPTVKDRARGIELRSVTAPPQLQVQSTPPSRLRASFLPARNDHTHTTSPSRPRGAKVPDTSAGATRKELLQKDISPTLLGQPSTPSRSVSQEAREPDAPPGASSEEHPSHAASDGMPILLTSATSDIEAPKSSNMSEASAEGDNVQDHRSLQSMPTDMPPSPPDSNIGLDFASSNDASSQPPISQEDASHAPQRIVHDAALAASAGPSVNVEKASQLHQNRGVAERAAARSDQLESPSVDHSTIVTGVDSTPSEPYGPVEHVATDALFVACDARSDDLPRNRNVQREASAESDQAASLPVVDSQGDTILHDHGGDHAEPPTTPSGSALEVYGTTGVCSERPAETMPMPAAHVEPLSDTSHDIHLDRFSSSEADPFAAIQARIQARRSIGGTSITSPVPIRRRTTGLSSISTASSSSLRSHLSKRHSQEKDQAAISTALVRKTASAFLGPPVHLVAIMLRIAARFAKGAFPKVLLFESPAGMPKRVPGSFDLDDSDIEDEFGSEDEDEENEDDFGVPLRSPIRLVANENLPRTMWESHKKDRERGLVGSSEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M3D4C3</accession>
    <name>M3D4C3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_83499</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761171.1">
        <property type="nucleotide sequence ID" value="XM_016910335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D4C3"/>
    <dbReference type="STRING" id="692275.M3D4C3"/>
    <dbReference type="GeneID" id="27907472"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064330_0_0_1"/>
    <dbReference type="OMA" id="WALFQFM"/>
    <dbReference type="OrthoDB" id="3650438at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189:SF50">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="234"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF13050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="277" mass="30486" checksum="A48C367B414C15D0" modified="2013-05-01" version="1" fragment="single">MHILEAFDFDVVDKTVFKDNKEVSPQHLQLIANLRHAAANSDLSAATEAFTTLRYTSASPSTLQKPGNALELAIDRRDERMVAYLLSEGVRVGAEDMRAAVLLRAKPIIRLLLDHGWPINAKLGWYEPPAMALAIDDLELVKWFLSLGADPNAPCGIDITPLSVAVHKGPLAVIDTLFAHKGTVNRGQLLHWAALRRQDDRLAVVKLILQKGAAVNSILYENDEDSFIQRKSFSLGTPLHEAARVGHLDVVQLLLDHGADVTIKDTRGDLPYDVALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M3D5R7</accession>
    <name>M3D5R7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_125261</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761616.1">
        <property type="nucleotide sequence ID" value="XM_016901967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D5R7"/>
    <dbReference type="STRING" id="692275.M3D5R7"/>
    <dbReference type="GeneID" id="27899104"/>
    <dbReference type="eggNOG" id="KOG3041">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062658_0_0_1"/>
    <dbReference type="OMA" id="WHWAAGW"/>
    <dbReference type="OrthoDB" id="10249920at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047631">
        <property type="term" value="F:ADP-ribose diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006753">
        <property type="term" value="P:nucleoside phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019693">
        <property type="term" value="P:ribose phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18888">
        <property type="entry name" value="NUDIX_ADPRase_Nudt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000016">
        <property type="entry name" value="ADP-sugar pyrophosphatase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839:SF26">
        <property type="entry name" value="ADP-RIBOSE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839">
        <property type="entry name" value="UDP/ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="52"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF13495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="207" mass="23306" checksum="C6F4668EAE19F12C" modified="2013-05-01" version="1">MSSPAQAPKINRISPLAADEAKWTELRKIEWTDQDGKNRIWEAAARKTRSKGGVDAVAIAPILRHPNKPPQTMIILQYRPPVDAYCVEFPAGLIDEGESPEEAAVRELKEETGYEGKVVDCSPTIVADPGLTNANMQMVTIVVQLKEGDEEPQQHLDEGEHIERRVVPLDQLYEKLQELSKEDGKIVDARLFHWALGLHWSRKLLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M3D786</accession>
    <name>M3D786_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_40425</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762146.1">
        <property type="nucleotide sequence ID" value="XM_016908783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D786"/>
    <dbReference type="STRING" id="692275.M3D786"/>
    <dbReference type="GeneID" id="27905920"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025001_1_0_1"/>
    <dbReference type="OMA" id="DSQAFPI"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF232">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="5"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="525"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF14025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="578" mass="65453" checksum="AD059CBCE6C7E281" modified="2013-05-01" version="1">MPLQLILLVPIVGILACTFIWYTAKPKPIPGIPYNPASADRLLGDIPDSLAHLAETSELWSFFEQRCRELGSPIIQVFMRPFSKPWVILVDCRESHDIMTQRGREFDRSGFMKKMFAPIFPKNQICMPTHDQWRYNRLLMRELMSPPFLDGVAAPLIHSTTLDLISVWRHKARLARGHAFEASRDVQFATLDTICSVAFGARVGITTSQEDNLNKLTQLDLPDSLDHVASIPETTLPEAWGALLATVTSGEIAMNSPLGSWHLAFAIKFYPRLRRAFAFRNKLINDGLHHARQRVSHTNPQDEEVPEVKCAAEWVVERASKLAEKDGEGKKNLPDHQVLFDELAGFLQAGFDTTSSTIHWGLKYLTGYQNVQQKLRTSLLDAFCEARQAGRQPTAKEICKTSIPYLDAFIEESLRHSCVISVNMRVAIRDADVLGYVVPRGTDVYMLTNGPSILRPAMPIDENKRSHSSREYKSSADSWNSENLDQYNPDRWLIEEEEGENGGKVVKFNSRAAPMQNFGSGVRACYGKKLAYQNLRIIYVLIVWNFILDPLPEALEEWKATDGMTHLPQHVRLILREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-09-13" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M3D8E5</accession>
    <name>M3D8E5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_154965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762275.1">
        <property type="nucleotide sequence ID" value="XM_016907595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D8E5"/>
    <dbReference type="GeneID" id="27904732"/>
    <dbReference type="HOGENOM" id="CLU_1971869_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032389" description="Extracellular membrane protein CFEM domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF14154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="127" mass="13949" checksum="0180CA44A59FF929" modified="2013-05-01" version="1">MRFSLLIFAVMGSVALAGDEDDNGDLQEYCVCGNNFDPESPIFMTIFNATIDSCTGLLWTLGWYDDMPHCYHTGEFEKIQTFADECVKKPENRATGAQCCPPYDEANPDAPCDHKLGNTGDDPAAIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M3D8P9</accession>
    <name>M3D8P9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_148036</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762390.1">
        <property type="nucleotide sequence ID" value="XM_016904663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D8P9"/>
    <dbReference type="GeneID" id="27901800"/>
    <dbReference type="eggNOG" id="ENOG502RGRK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_531178_0_0_1"/>
    <dbReference type="OMA" id="HEAYDEP"/>
    <dbReference type="OrthoDB" id="3643115at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF14269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="513" mass="57952" checksum="DC368C8815F4D4C1" modified="2013-05-01" version="1">MSTLHLPEEILNLIVEHLQLPSAIEIGERRNPDFTGKLSDSDQAIKLQLFTLASLARTSLRLNRIVKPVLYRTYPGFPLANARTFIETLAKDPVCAGSVHEIVIDKWEHLTQDDQHTVDLESQSLKTSCLQYAQSMRRVSSCYPVGLGSAVGAKLERGRADVVLTMLMLLCDNIEVLEVSVPCLGFDAQRGTHLRLTPLFFMLDVLAYSKDHSEERYRKIRNLAIRLEKHMGVFGCAFANRLLSMPNVETFSGWRVNCSRLFTSRTIGIPDTETLWPGLKSIELRQCQLDNVMLAYLLRRAPNLRQIDLQWAVQEYPLDFQSIAASLNTFGTHLESVRLDTRNNFCNLPEADPEPTGTRIHEAYDEPLGNLQPMTNLLHLAVTPRALVGSHRFFNNPSQEQHNPLVHNNSNNNNNNNHLLLLPPHLQTLHILGPTREDPDVALTTAVYHQVLHPAITREATTCPDLRRIELSCSAFAPEKYRCCSPGWEVEASEWENVGPVAAWKVVLKKKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M3D978</accession>
    <name>M3D978_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_41039</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762826.1">
        <property type="nucleotide sequence ID" value="XM_016908808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D978"/>
    <dbReference type="STRING" id="692275.M3D978"/>
    <dbReference type="GeneID" id="27905945"/>
    <dbReference type="eggNOG" id="ENOG502SI13">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031053_1_1_1"/>
    <dbReference type="OMA" id="VVCRNCT"/>
    <dbReference type="OrthoDB" id="1668230at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF14705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="367" mass="40063" checksum="818A7760C88360F0" modified="2013-05-01" version="1">MVGDDNSRPNPNLNTFTAALSCYPIASSLASYIDLTTLSDLAQTCRQVRANLLQYRAMLVKKTLRCHNEDSSPGERLGAALLASRDAWTTYGRHGIKVERITSGRVGACARDMVSDCRSCGRTLCRNCVIKAPPSSAVKLRHRRLCRTCMKAPLSELTSTICAFDEAGVHVSISAREYRKYARDPCTCSDVVWICSPCGHAMRTADTTYERGWKWRGRYSHCGGIGAGLGEGNEGVECGRTSDCLGARMVQKDVECDAEELAALELETAKAESEGRCWNGSSYSTQEMVGIGGRVKTKVRKMVPVGAIVKEYEDERISEKFLEREQTGVNRSWCSWCSRVIIGNKDLDGAARSQESIASAGNSAGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M3DAK4</accession>
    <name>M3DAK4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Auxin efflux carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_146920</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF14889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763010.1">
        <property type="nucleotide sequence ID" value="XM_016903962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DAK4"/>
    <dbReference type="STRING" id="692275.M3DAK4"/>
    <dbReference type="GeneID" id="27901099"/>
    <dbReference type="eggNOG" id="KOG2722">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026460_1_0_1"/>
    <dbReference type="OMA" id="WSWGYHI"/>
    <dbReference type="OrthoDB" id="10267235at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_transp_PIN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31794">
        <property type="entry name" value="AUXIN EFFLUX TRANSPORTER FAMILY PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31794:SF2">
        <property type="entry name" value="AUXIN EFFLUX TRANSPORTER FAMILY PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="502"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="538"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="571"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="242"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="279"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="316"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF14889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="602" mass="66368" checksum="56E80BD84386B949" modified="2013-05-01" version="1">MPFHTPKSFRLRELASASLVAFKQRRSITDQSVPMSYPLWEAAANITMDAITTTAHESHPNFVHLAGLVSEAVLEVVFVALPGYLVAITGMFDANSQKFLAELNTMVFTPCLIFTKLASQLNADKLADLAVIPFIFVIQTIVSYTAAQIMARLFGFGKKNKKMQKNFVLAMGVFGNSNSLPISLVLSLSKTIQGLHWDRIPGDNDEEVGARGILYLLIFQQLGQLLRWTWGYSVLLKPADQYSASERGDDDEERARLIEDGPGFDGTDDTIKGKGGSDSGFNSASETPTSSSTASREDLRQEIIPATPANGNDISTEPRKLHRRNVDDDTDSVRSASTTSITQFPQFSRTQSSRSTAEAPVGWKAPLYRVQNTVVMYARRVWLTISTFFINLLRALPTPVQKVLRTFHYYNSKFWAGVWRQMNPPLWAMLAALIVASVPRLQQLFFDDGTLIRNSVTRAIEQSGGVAVPLILVVLGANLARSTLPQDQLATSPEEKKEERKLLYASLLSRMVVPVVIMAPVLALTAKYVPVSILDDPIFIIVCFLLTGAPSALQLAQICQLNNVFMGAMSSLLVASYVVVIFPSTLLLVLMALEVLEWAVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M3DD15</accession>
    <name>M3DD15_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_147518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763830.1">
        <property type="nucleotide sequence ID" value="XM_016904349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DD15"/>
    <dbReference type="STRING" id="692275.M3DD15"/>
    <dbReference type="GeneID" id="27901486"/>
    <dbReference type="eggNOG" id="ENOG502S0QA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036524_0_1_1"/>
    <dbReference type="OMA" id="YDNSHDY"/>
    <dbReference type="OrthoDB" id="16547at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33594:SF1">
        <property type="entry name" value="HD_PDEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33594">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G03035)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD/PDEase" evidence="1">
        <location>
            <begin position="34"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF15709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="226" mass="25608" checksum="F418D07A52A4A8EA" modified="2013-05-01" version="1">MSSLQDDNKVVPFESTKLYEQAYGYVQEYMSRYDCSHDFNHILRVLALSKHILAEEIKTKPTKNFDERAVILAALLHDVGDKKYVQPGENAEQLVSDFLSRNGCAPKDVAKIALIVENVSYTNEIKRPQLVKAHINSHPELAIVQDADRLDAIGAVGIGRVFAFGAVKASARGLQGSMDHFDEKLLKIEHMMKTQTGKQLARERTERLKQFRRWWYEETQAASATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M3DE49</accession>
    <name>M3DE49_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4484 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_131599</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF16040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764161.1">
        <property type="nucleotide sequence ID" value="XM_016902437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DE49"/>
    <dbReference type="STRING" id="692275.M3DE49"/>
    <dbReference type="GeneID" id="27899574"/>
    <dbReference type="eggNOG" id="KOG4704">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019791_0_0_1"/>
    <dbReference type="OMA" id="GYTIVWK"/>
    <dbReference type="OrthoDB" id="2152680at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028115">
        <property type="entry name" value="DUF4484"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018626">
        <property type="entry name" value="LCHN/Anr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053056">
        <property type="entry name" value="Lipid_Metab_Assoc_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28153:SF1">
        <property type="entry name" value="DUF4484 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28153">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09804">
        <property type="entry name" value="DENND11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14831">
        <property type="entry name" value="DUF4484"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4484" evidence="2">
        <location>
            <begin position="386"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4484" evidence="2">
        <location>
            <begin position="485"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF16040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="538" mass="59530" checksum="DC146730119AD552" modified="2013-05-01" version="1">MSGRDKPPVVAVFLVVFDQKVGYTIAWSRSLDDVDLDGVEFKSLPSGLHAVKEDLVFFLHGAHAGVSAFVQEEADARHRNASFVAVGALVPSGYGQLGRSWTHAEELRSMGKDAVKNTAHMDALEAFWETHRADNSAGSLPAPLLANRDNGGSEHQARRKRAASETTMGLHTDGAWPSDHPALQVPAMLETFGPLLFPLHRAALSRSRILLLGSPSVQNNTNLVYMASVLSSITKELAESLPTEAEPIFRSSPLFSIGIHDIPDLTKRSGDNGGWIATTTDGILGDKKNLYDLLVRLPPQAASSWSWPELRTATGRVVKASQRDLQRWNLLRREMGRLRRQAVTAFVDESPTTNENDRRPLLERRNTSRDDVNDVEFLDRDSTDVVEPPTWSAMAYRGFMWWASAGDVTAWENDDAKADEELLFDMPDIGGILAEESGLRGESEYARAAATLLVAYFRNVTESILRPMASIVEAADDDTEEGVEENEIPFGSNDLRAMGLDSWSEPDRLFVKDMLQTWFHRDAVIVDNGVRVCGMRVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDJ3</accession>
    <name>N1QDJ3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sm protein F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_151492</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SO2202</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2012-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genome evolution in poplar pathogens from wild and recently domesticated pathosystems.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Dhillon B."/>
                <person name="Feau N."/>
                <person name="Sakalidis M.L."/>
                <person name="Gill N."/>
                <person name="Aerts A."/>
                <person name="Ohm R."/>
                <person name="LaButti K."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Copeland A."/>
                <person name="Beauseigle S."/>
                <person name="Grigoriev I.V."/>
                <person name="Goodwin S.B."/>
                <person name="Tanguay P."/>
                <person name="Hamelin R.C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757621.1">
        <property type="nucleotide sequence ID" value="XM_016906853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QDJ3"/>
    <dbReference type="STRING" id="692275.N1QDJ3"/>
    <dbReference type="GeneID" id="27903990"/>
    <dbReference type="eggNOG" id="KOG3482">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076902_12_3_1"/>
    <dbReference type="OMA" id="GYMNVQL"/>
    <dbReference type="OrthoDB" id="409625at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034715">
        <property type="term" value="C:pICln-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008266">
        <property type="term" value="F:poly(U) RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990935">
        <property type="term" value="F:splicing factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036261">
        <property type="term" value="P:7-methylguanosine cap hypermethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01722">
        <property type="entry name" value="Sm_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016487">
        <property type="entry name" value="Lsm6/sSmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034100">
        <property type="entry name" value="Sm_F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021:SF0">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F SNRNP-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006609">
        <property type="entry name" value="snRNP_SmF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="7"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF09500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="89" mass="9744" checksum="CB90CD64C8CD5BB5" modified="2013-06-26" version="1">MSFIPLNPRPMLQGLVNKDVIVRIKWGQEYSGRLVSVDSYMNIQLSGAEEKSPDGHDGGVLGQVLIRCNNVLWISAKDKQANGDSEMAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2023-02-22" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDT3</accession>
    <name>N1QDT3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_111171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757852.1">
        <property type="nucleotide sequence ID" value="XM_016900901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QDT3"/>
    <dbReference type="GeneID" id="27898038"/>
    <dbReference type="HOGENOM" id="CLU_1994034_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="125" mass="14421" checksum="EF730F726103BA60" modified="2013-06-26" version="1">MRYPTTWEVYVHLYFERTDTDTADGEEIPRPRHCTEDVSEREWERLQTRLPRREEKKLKSGPCIHSTGITLDPTAGPATTHVNPLHYPSIPEQLELQQARAGGHYEGKPHKRSERAVIITSYGIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDU8</accession>
    <name>N1QDU8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_13303</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758461.1">
        <property type="nucleotide sequence ID" value="XM_016902534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QDU8"/>
    <dbReference type="STRING" id="692275.N1QDU8"/>
    <dbReference type="GeneID" id="27899671"/>
    <dbReference type="eggNOG" id="ENOG502SQDU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057752_6_3_1"/>
    <dbReference type="OMA" id="ANLTHEW"/>
    <dbReference type="OrthoDB" id="3649185at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF5">
        <property type="entry name" value="BTB_POZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="9"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF10340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="166" mass="18409" checksum="6FB62BB7B0CEE59A" modified="2013-06-26" version="1" fragment="single">RLLVTGEHSDLIITCNGHKWSVHKAIVCLASDFFQACCKNFKEASSGVIDLPDDRSDAVNALLWYAYTANYDDTKECSVSDGQLIPRPMLFNVLVHTVGDKYGMRNLCQLAEAKFEKHATTEWRSDGFADAIIEMSLTSPDPKRVLLKIAAEIAITHAADLFTGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDY8</accession>
    <name>N1QDY8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hsp90 chaperone protein kinase-targeting subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_150552</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC37 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758572.1">
        <property type="nucleotide sequence ID" value="XM_016906254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QDY8"/>
    <dbReference type="STRING" id="692275.N1QDY8"/>
    <dbReference type="GeneID" id="27903391"/>
    <dbReference type="eggNOG" id="KOG2260">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033261_0_0_1"/>
    <dbReference type="OMA" id="NYSKWDQ"/>
    <dbReference type="OrthoDB" id="440202at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.610:FF:000002">
        <property type="entry name" value="Hsp90 co-chaperone Cdc37, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.610">
        <property type="entry name" value="Cdc37, Hsp90 binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004918">
        <property type="entry name" value="Cdc37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013873">
        <property type="entry name" value="Cdc37_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013874">
        <property type="entry name" value="Cdc37_Hsp90-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038189">
        <property type="entry name" value="Cdc37_Hsp90-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013855">
        <property type="entry name" value="Cdc37_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800">
        <property type="entry name" value="CDC37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800:SF4">
        <property type="entry name" value="HSP90 CO-CHAPERONE CDC37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08564">
        <property type="entry name" value="CDC37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08565">
        <property type="entry name" value="CDC37_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03234">
        <property type="entry name" value="CDC37_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01069">
        <property type="entry name" value="CDC37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01070">
        <property type="entry name" value="CDC37_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01071">
        <property type="entry name" value="CDC37_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101391">
        <property type="entry name" value="Hsp90 co-chaperone CDC37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cdc37 N-terminal" evidence="9">
        <location>
            <begin position="2"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc37 Hsp90 binding" evidence="8">
        <location>
            <begin position="200"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc37 C-terminal" evidence="7">
        <location>
            <begin position="403"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="190"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="492"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="213"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="243"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF10451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="514" mass="56967" checksum="0A4C9AB40735B2B9" modified="2013-06-26" version="1">MPVDYSKWDALELSDDSDIEVHPNVDKRSFIRAKQNQIHQQRIDRKFRITTLKYERVVNDGLLLRIDALLKALNSHTAEVQDKKDAEGIDEVVFDCLMELTSDTSLGPDQPSNPPPGVHSKEQQPTYSKMMGALVDQVKSEIDKTGAVGPARYTAFIKEVESHNKKVQGLQKDLNVELAKLEKEEGSKITSESIHTGFDTSHVAKAQPAEPQATVTKTSKQPQLLNPGRVQQIGGPSSGYEAGVEDDALNPAPGEDEDDIEEAAPIAKKFGSIAYGDYKTSLNFIGSNPGIMSDKHTDGLLVEAFTAQQNAKSKKEEDYARQCVHQALLLQYCRQLGKDGVGLFFQRVQTPNHQARKLFLDDVNSTYARIRSRTAELAKQQAEEDNGDKEQIQLHAVDPNTTINIVTPPPLDQCQSEDEKTARSIFDTFPPGLQRALETGSLDKVNEVLGKMSVQEAEEVVEQLGNGGMLSLEEGVYDATTDEGKKAIEELEKKHRTSAQEEKQERVVEVDDMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1QE08</accession>
    <name>N1QE08_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Isochorismatase hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_165182</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758622.1">
        <property type="nucleotide sequence ID" value="XM_016908156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QE08"/>
    <dbReference type="GeneID" id="27905293"/>
    <dbReference type="eggNOG" id="ENOG502QTD4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068979_8_0_1"/>
    <dbReference type="OMA" id="DAGIMGW"/>
    <dbReference type="OrthoDB" id="167809at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00431">
        <property type="entry name" value="cysteine_hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540:SF9">
        <property type="entry name" value="FAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
        <property type="entry name" value="PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="37"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF10501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="255" mass="27937" checksum="4AF6C37C2957BB33" modified="2013-06-26" version="1">MLMNRRKLVVIPSRCWGQLKAKPYLWPHDASLHPQTTALLVVDMQRDFCEEGGYLSHQGYDISLTRAIIPAITTLLHTCRHLEYPIYHTREGHRPDLSDLSARELFRSRNNALGLGIGDAGPLGRLLVRGEAGHDTLPELYPHVGEPVIEKPGKGAFTNTDLELLLRVKGIKNLIICGVTTDVCVHTTMREANDRGYDCVLVEDACAASTEELHTLTVLSTKAEGGVFGAVASVKDIIAGLQAPRTVRHGCSTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1QEJ7</accession>
    <name>N1QEJ7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_150829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758992.1">
        <property type="nucleotide sequence ID" value="XM_016906424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QEJ7"/>
    <dbReference type="STRING" id="692275.N1QEJ7"/>
    <dbReference type="GeneID" id="27903561"/>
    <dbReference type="eggNOG" id="KOG4150">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_473413_0_0_1"/>
    <dbReference type="OrthoDB" id="18781at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18797">
        <property type="entry name" value="SF2_C_Hrq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055227">
        <property type="entry name" value="HRQ1_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47957">
        <property type="entry name" value="ATP-DEPENDENT HELICASE HRQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47957:SF3">
        <property type="entry name" value="ATP-DEPENDENT HELICASE HRQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22982">
        <property type="entry name" value="WHD_HRQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="1">
        <location>
            <begin position="101"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF10871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="576" mass="64523" checksum="85D62B1FD6FD3981" modified="2013-06-26" version="1">MDELHVYNGLFGAHVAFIMRRLRRICAAVGNRKVKFISCSATVANPEEHMRTIFGIEDIKLIDFDGSPCGRKEFVCWNTPYKDPGDPTSGRGDTFMETARLFCQLVLRGVRVITFCRIRKQCEILVGAIKNELESLGRTEVMNRIMAYRGGYTAQDRRRIEKEMFEGKLVGIIGTSALELGVDIGSLDAVISHGFPYTIANLRQQSGRAGRRNKDSASFLVGDCFPTDQYFMANPDEIFTRPNCELQVDLTNLLVLEGHVQCAAFEMPIAPDEDEKYFSKQLSELCNDRLRRDDLGFYHTAERFLPHPSRSVAIRDTEDNHFAIIDTTHGRNVVLEELEASRAFFTIYEGGIFLHQGKKYLVKHMSTEQMIAKVELVKVDWITQQRDFTDIDPIETEAIRRIPGSLSRAFFGNIKILQNVFGFFKLDKKNRILDAVQVDNPPIIIFSKGMWLDVPREAIEILNSRRLNLAAGIHAAEHAILSLMPNFVISMPGDVKTECKVAKLLANDPLASPSTTTKAVPTAPESPPKLLNLSISFSLKLAIASKLAIVSTVVSNVAVVKVAKKRIKSCPKPAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>N1QEY6</accession>
    <name>N1QEY6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PLC-like phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_66980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759869.1">
        <property type="nucleotide sequence ID" value="XM_016909770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QEY6"/>
    <dbReference type="STRING" id="692275.N1QEY6"/>
    <dbReference type="GeneID" id="27906907"/>
    <dbReference type="eggNOG" id="ENOG502S6H7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045947_0_0_1"/>
    <dbReference type="OMA" id="KVMHVQD"/>
    <dbReference type="OrthoDB" id="2017497at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08589">
        <property type="entry name" value="PI-PLCc_SaPLC1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032075">
        <property type="entry name" value="PI-PLC-C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16670">
        <property type="entry name" value="PI-PLC-C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF11748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="414" mass="46614" checksum="440A8035B742C06D" modified="2013-06-26" version="1">MSIQLKAAFVLCFLVIGIGLYTMRLQTVLPLALTPGLFPSGADAFVWRPSAQGNKNGLRLNHIQVVGTHNSYHREVALTERKVLEQYISGYQNLYYSHSSFSNQLNYQQVRSLEIDLHSDERGGLYADPLIWKLSNLTSGPNGTAPYDNTVMMKPGLKVFHMTDVDTNSVCHTFTDCLTQLKAWSDAHPNHLPLTFDLELKTDSFAAILGGSSDEEATNFTLPRILNVDKEIRAVLPREKLIIPDDIRKSGMTLEASVLKYGWPTLQASRGKFLFFFDNDPSNVTTDIRTLYRSDGHESLQNRTVFTNAVEGDSDCAFLKHNNPDIRAIQRLVRKGYLVRTRADEPITTIINRNLTMREDAFASAAQIVSTDWPAYGMSARWDRDYAVQLGKGRVARCNPVSAPMWCRDEMVQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFC4</accession>
    <name>N1QFC4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mitochondrial import inner membrane translocase subunit TIM22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_8250</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the TIM22 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760018.1">
        <property type="nucleotide sequence ID" value="XM_016910310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QFC4"/>
    <dbReference type="STRING" id="692275.N1QFC4"/>
    <dbReference type="GeneID" id="27907447"/>
    <dbReference type="eggNOG" id="KOG3225">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091077_1_0_1"/>
    <dbReference type="OMA" id="VNPNMAD"/>
    <dbReference type="OrthoDB" id="75343at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042721">
        <property type="term" value="C:TIM22 mitochondrial import inner membrane insertion complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039175">
        <property type="entry name" value="TIM22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14110">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14110:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF11897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="161" mass="16367" checksum="7FF8D6760ACC40A8" modified="2013-06-26" version="1" fragment="single">MGGRAAASQDPEVIQQQQMIKLMENTMQSCPAKAVMAGGMGFALGGAFGLFMSSMRYDTPLSSGAPGGVGTGNIPSIPIKEQLKTGFRDMGRQSLSSAKNFGYIGALFAGTECCVEGFRAKNDLSNQVAAGCFTGAFLAKGAGPQAMAVGCAGFAAFSAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFH3</accession>
    <name>N1QFH3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_149836</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760174.1">
        <property type="nucleotide sequence ID" value="XM_016905801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QFH3"/>
    <dbReference type="GeneID" id="27902938"/>
    <dbReference type="eggNOG" id="KOG2615">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_10_2_1"/>
    <dbReference type="OMA" id="EWYVNIS"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000223">
        <property type="entry name" value="Major facilitator superfamily domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF31">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="12"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF12053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="461" mass="49335" checksum="CC55950C932D9137" modified="2013-06-26" version="1">MGDFPLQQRQKVLKVLIISLILDLISFTFILPLFPKLLEFYRNVETQSDSTVLSQVLYGLNAYKNSFERPINDRYDIVLLGGALGSLFSLCQAIVSPIIGALSDKYGRRTALLCSMCGNIASVALWCAATDFRTFLASRIVGGLSEGNVQLALAIATDISTDQDRGKTMALVGACFSVAFTFGPALGAWLSGINSVAANPFATAAGVSLALIVTETIYLYYALPETHHAHQPKTNGSSTKATDNNAPLEKHTRTNSHLLLNMTHFAFILFFSGMEFSLPFMTYDLFSYGSKQSGKLLGFIGLVASILQGGVTRRMHPLRVVQLGVVSAAIAFFLLSRTTSEKELYTAAALLAVTSSTVVTGLNSLSSFEASKDERGEKLGNHRSFGQAGRALGPLIFCTLYWWTGRDTAYMIGGSGMVAVCGLVFGGLKAPKGLEVKKPVKAAKAAVANGTAQANGSMKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFM2</accession>
    <name>N1QFM2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ubiquitin-conjugating enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_149872</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760224.1">
        <property type="nucleotide sequence ID" value="XM_016905825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QFM2"/>
    <dbReference type="STRING" id="692275.N1QFM2"/>
    <dbReference type="GeneID" id="27902962"/>
    <dbReference type="eggNOG" id="KOG0418">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030988_13_1_1"/>
    <dbReference type="OMA" id="THLRGQF"/>
    <dbReference type="OrthoDB" id="9993688at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016050">
        <property type="term" value="P:vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="8">
        <location>
            <begin position="4"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="157"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="5">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF12103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="254" mass="28373" checksum="151BC6CD1F857BC2" modified="2013-06-26" version="1">MATNRTRRLQKEIADIIKDSHSGIRITDPQGNSDISDFTRFTGSFTGPPDTPYEGGLYQIDIRITGEYPFKPPEMRFLTKIWHPNVSSQTGAICLDTLGTAWSPVLTLKSALISLQSLLSSPEPKDPQDAEVASMLLTRPEQFKHVAREWAILYAHAPPPRPGTGKGGASSSLDEKEQKKAEDKAEKQRKEAARVASYHGYNQRMINQFTEMGFGVEQIVAAFEWVGIDKADGEYYELEEEYLGDVTAKLFNET</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFW5</accession>
    <name>N1QFW5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Terpenoid synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_51612</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757544.1">
        <property type="nucleotide sequence ID" value="XM_016909196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QFW5"/>
    <dbReference type="STRING" id="692275.N1QFW5"/>
    <dbReference type="GeneID" id="27906333"/>
    <dbReference type="eggNOG" id="KOG0777">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014015_6_0_1"/>
    <dbReference type="OMA" id="LISHAVW"/>
    <dbReference type="OrthoDB" id="6921389at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046165">
        <property type="term" value="P:alcohol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF44">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF09423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="382" mass="43335" checksum="774EB5CBD88A74E5" modified="2013-06-26" version="1">MCGALELSRESHKNSDTDSFEAEHNLSQSIDHKLSHQWEECNEKAPPYDYVASMPGKEIRRQLLNALNHWFQVDEISSNIIAETVTMMHNASLLIDDIQDNSQLRRGFPSAHQVYGVAQTINSANYVYFQAQQHLLQHLPKGGGVEEAAIIRIFNEEMLNLHRGQGMELYWRDTMQLPPSEAEYLQMVSNKTGGLFRLILRLLRVMSPVEHVMAVNVDVISKVVDVMGLQFQILDDLKNICDEKMAKQKGFFDDLTEGKFSYPIAHAIWKEKNHNTPPSPENSSSERKHLLIEFLAMRTQDNTIKIEAIQCLQRAGSLNHTKQVLKTLDQRARFLMGEVGVKNPLLEKVLDQLVDGLGRMDVGSQLSVEEGGRLTSLKQESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGI8</accession>
    <name>N1QGI8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial import inner membrane translocase subunit TIM17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SEPMUDRAFT_55533</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the TIM23 complex, at least composed of TIM23, TIM17, TIM50 and TIM21.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Mitochondrion inner membrane</location>
            <topology evidence="2 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764442.1">
        <property type="nucleotide sequence ID" value="XM_016909365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGI8"/>
    <dbReference type="STRING" id="692275.N1QGI8"/>
    <dbReference type="GeneID" id="27906502"/>
    <dbReference type="eggNOG" id="KOG1652">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087811_3_0_1"/>
    <dbReference type="OMA" id="FDCTFQY"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005678">
        <property type="entry name" value="Tim17"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00980">
        <property type="entry name" value="3a0801so1tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10485:SF0">
        <property type="entry name" value="AT05822P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10485">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM-17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="145"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMF16321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="171" mass="17564" checksum="358C4C33BA45D749" modified="2013-06-26" version="1">MGEKGHGLDHSRDPCPWVALSDFGGAFCMGAIGGAVWHGVKGFRNSPYGERRIGAITAIKARAPVLGGNFGVWGGLFSTFDCAVKGVRKKEDPWNAIIAGFFTGGALAVRGGPKAIRNGAIGCAILLAVIEGVGIGFQRMMAENTKLEPPAPPPTQTSASGSEGRLAASVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGS9</accession>
    <name>N1QGS9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Beta-Ala-His dipeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_121961</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764552.1">
        <property type="nucleotide sequence ID" value="XM_016901742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGS9"/>
    <dbReference type="STRING" id="692275.N1QGS9"/>
    <dbReference type="GeneID" id="27898879"/>
    <dbReference type="eggNOG" id="KOG2276">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008535_0_0_1"/>
    <dbReference type="OMA" id="HATVCVD"/>
    <dbReference type="OrthoDB" id="7832001at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061672">
        <property type="term" value="C:glutathione hydrolase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051458">
        <property type="entry name" value="Cyt/Met_Dipeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017149">
        <property type="entry name" value="GSH_degradosome_Dug2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270">
        <property type="entry name" value="BETA-ALA-HIS DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270:SF8">
        <property type="entry name" value="DI- AND TRIPEPTIDASE DUG2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037237">
        <property type="entry name" value="Peptidase_WD_repeats_DUG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="95"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="255"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="365"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="828"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="828"/>
            <end position="838"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF16431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="938" mass="103739" checksum="992EE340B71EA7A4" modified="2013-06-26" version="1">MSSLMTGSETDDANLDAPQPSRQQQQQQSRYALSRQPSQGDVGEPTNAIPTLSQRLRHTSSILAIVISDDHIYAGTQLGEILVYSLSTYAKQGVIEGHRGSVLGLHLSQDQTLLFSSAGDRIVNVWSTKTLKRICCLYSSFDVGDVFCVAYSTSLETAYLGAQNTTIQWCRISQQSAATVPAPLRGDDRFFDSRGPGGVQTPRPAGSDYVPRHARGGDVIEIGKDNVRHFAHYGYVYCMLLAKDGVPERSGEDTLVTAGGDGTIKLWKLDAKNGGAIEELYTLDDGREEGHSILSIAMDGSFLYSGRSGGEVDVWDLETRQLVRNIKAHRDDVHTIAVGGGFLFSAAVTGYIRKFDRQYQLKTRWRAHNGRILASAFSYNNSRPIYATGSNDNSIAIWDVSDCIRLSIIPSKTSNEQLVESLRRFVSFRTVSSDQRLKADCRRGASYLRSVFKNFGATTEMLPAEDGCNPIILARFRGNPATASQRKKILFYGHYDVVAASNDSGKWHVDPFQMEGIDGYLYGRGTSDNKGPIMAAIFACAELMSEQALGSDIIFLIEGEEECGSRGFERAVKASKDKIGDVDWILLANSYWLDDRIPCLTYGLRGVIHATVQIESSHPDLHSGVDGSAQLDESLKDLVMLLSTLTGKNGEVKIPGFYDPVPEMSKEEAELYEDITTALVLRNPDLGDQRALATSLMRRWREASLTIHRFQTSGPDNATIIPRMAKAALSMRLVPNQEATEVSAALTSYLEAEFEKLESNNRLLVTIDHKAEPWLGDLNNDIFKTLEEAIMEEWGPIDQTHHRRKSSGHPLKITPVSPEFDGHYLTKPSPTTSKTLASGSLEPLSPMTPMTEITNKLEEIATHQEEKPSPRRKPLYIREGGSIPAIRFLEKEFGAPAAHFPCGQASDSAHLDNERLRLVNLFKSKNIMKKVFRDLPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>N1QH17</accession>
    <name>N1QH17_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_145713</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764596.1">
        <property type="nucleotide sequence ID" value="XM_016903222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QH17"/>
    <dbReference type="STRING" id="692275.N1QH17"/>
    <dbReference type="GeneID" id="27900359"/>
    <dbReference type="eggNOG" id="KOG0596">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_2_10_1"/>
    <dbReference type="OMA" id="CMEPPSY"/>
    <dbReference type="OrthoDB" id="20524at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033316">
        <property type="term" value="P:meiotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098813">
        <property type="term" value="P:nuclear chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14131">
        <property type="entry name" value="PKc_Mps1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000131">
        <property type="entry name" value="Dual specificity protein kinase TTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027084">
        <property type="entry name" value="Mps1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974:SF21">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE TTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974">
        <property type="entry name" value="MIXED LINEAGE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="569"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="63"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="734"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="243"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="312"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="350"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="364"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="739"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="597"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF16475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="913" mass="100727" checksum="38F7BFB820D46FD9" modified="2013-06-26" version="1">MAAVAHPSRPAFRRNSPLSGFGPNGFSADAPMIKRIDVGDDSDSDDEPPPAIKFSKVTQALLADAGVPSSPPRQAPAGAMPRYNRSTSAGTAGLDTPSRVPGLKVVRRSPPPGSHDQKDRGTPLRVVHLGAKGPASAKRSISISGPYPNRGMKRDPTPETNVRPEVVTPAPAPRAIRVVTRSRAGSNASQDEPAHMVSSYSRPGSRNDTRAAPDTNERTNYRSELARSTSAQYVPETVSRYGTSTAARSRNASAESAAPPGSQRVKRAPMTGSFLKSGPIRRGFKRRDSEENNSANDEGPHGSSSQPSASSYTPQDRSMSQLDGARSRSGSVNTRATSVEPVSIHDFAHRSQSSQHSRPPSRQAESRLSRSQTRSDSKPPSRQTSREPSHNRQPSAERHQVRRQPSSQQMTGSALASQQQRRPSIGQGHMDSAAEQSHHQRMASYARTNYRYDPPKVHTDAYEDQENMPPPTFRRNKDQEFKYLGKPTMSVMSDDEKLDRRHVEETPVIVSQQEPRRALGAISGNTPHRAAPAPPPKMSVLDAATARAGASTTKTRKKRTHIVVKGKIFTQMGRIGKGGSSEVYCVMAENYKTFALKRVKLEDCDETAVRGYKGEIDLLKKLTDVERVVRLYDWELNDEKKELLVLMEKGDTDFNRILTLRLNGTDARFDSVFTRYHWKEMLECVQAVHDYDIVHSDLKPANFLLVQGRLKLIDFGIANAIDTDNTVNVHRDSHVGTPNYMSPESITDTNATGKDDAGRPLKKDMRIGKASDVWSLGCILYQMAYGRPPFAHIGNQISRIMAITNPRHVIEFPEIGVGDVPIPSTLRGILRRCLNRDPDKRPLIKDMLGEADSYLNPEGMGNAVLMDEALLGQIINKVLDRCRDPGRGVPSPDEAMLYPKSFMMKIREMQEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1QH91</accession>
    <name>N1QH91_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_89693</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758644.1">
        <property type="nucleotide sequence ID" value="XM_016910507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QH91"/>
    <dbReference type="GeneID" id="27907644"/>
    <dbReference type="HOGENOM" id="CLU_2265409_0_0_1"/>
    <dbReference type="OrthoDB" id="15893at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF10523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="103" mass="11998" checksum="A34D14EF55A20509" modified="2013-06-26" version="1">MHRKREAGVWYYGPTVRPLTRPARLIAPKQLELDQAYCTNTESEESDLAAMFLRHTLGVQILSRQIRNFKMAHYVLCSSQFLRQHGKRNTLQYSQLCTSAIAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>N1QH99</accession>
    <name>N1QH99_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Branched-chain-amino-acid aminotransferase</fullName>
            <ecNumber evidence="11">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_145821</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="11"/>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764722.1">
        <property type="nucleotide sequence ID" value="XM_016903287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QH99"/>
    <dbReference type="STRING" id="692275.N1QH99"/>
    <dbReference type="GeneID" id="27900424"/>
    <dbReference type="eggNOG" id="KOG0975">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031922_0_1_1"/>
    <dbReference type="OMA" id="LTEVFAC"/>
    <dbReference type="OrthoDB" id="1732691at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.10.10:FF:000004">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.10:FF:000005">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01123">
        <property type="entry name" value="ilvE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009897">
        <property type="entry name" value="PRK13357.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825:SF44">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="SUBGROUP IIII AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 11 12" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 11" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF16601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="420" mass="46365" checksum="ADF63F0742D147C6" modified="2013-06-26" version="1">MALRTLFGRSASQKTFFATSTTTTWSTSARRLYSLRAPDSSDPRLSTIDASQLSVTTTTTPKEITPNADLVFGRAFTDHMLSLEWTASDGWLAPRITPYQNLSLDPATCVLHYAFEAFEGMKAYKDTQGRVRLFRPDKNMARLNKSVARIALPTFNGEAVIELLKKFVKLEERFIPSQKGYSLYIRPNMIGTQRTLGVGPPGSAMLYVIASPVGPYYPTGFKAISLEATDYAVRAWPGGVGASKLGANYAPCIVPQMQAATRGFHQNLWLFKDTDPTTGVEEDFVTEVGTMNFFVAIQHKNGEKELMTAPLDGTILDGVVRDSVLALARERMVPQGWKISERRFHMRELAEAAKEGRLLEVFGSGTAATVSPVRAISYKGELVDCGLPAGKEFGPVVEQMKNWIEGIQYGEEDHPWSVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>N1QHB0</accession>
    <name>N1QHB0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="10">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Lysyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_145792</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>tRNA(Lys) + L-lysine + ATP = L-lysyl-tRNA(Lys) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="10"/>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764696.1">
        <property type="nucleotide sequence ID" value="XM_016903273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QHB0"/>
    <dbReference type="STRING" id="692275.N1QHB0"/>
    <dbReference type="GeneID" id="27900410"/>
    <dbReference type="eggNOG" id="KOG1885">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008255_6_0_1"/>
    <dbReference type="OMA" id="DFRNEGM"/>
    <dbReference type="OrthoDB" id="21243at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00775">
        <property type="entry name" value="LysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000050">
        <property type="entry name" value="Lysine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000238">
        <property type="entry name" value="Lysine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00252">
        <property type="entry name" value="Lys_tRNA_synth_class2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034762">
        <property type="entry name" value="Lys-tRNA-ligase_II_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001756">
        <property type="entry name" value="PRK00484.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918:SF9">
        <property type="entry name" value="LYSINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918">
        <property type="entry name" value="LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039101">
        <property type="entry name" value="LysRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="12">
        <location>
            <begin position="287"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="24"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF16575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="639" mass="71414" checksum="2FE67476B2948401" modified="2013-06-26" version="1">MAAQQAADAVADAVSNAAEQVSALTMDGSSGGGGGANAASGGTQTNLQKDEVTGEMVSKSELKKRIKAREKEAKKTAAPPKQAPPAGKKKAAGSSGEQDDEAQLNPNQYFEIRSRAVKRMKETSSPNPYPHKYHVTYDLRDFQKDFGHLKKGDVVKDKIISVGVRIYNIRTSGENLRFYEVAVNGAEIQIMAQNLESTSATPFAAQHDILRRGDIIGVKGYPGRTSPKREDNPGELSIFAQEVTLLSPCLHQIPSEHYGFRDQESRYRNRHLDMIMNKSTVNTFIARSKIVRYVRNYFDNNGFYELETPILLKSAGGATAKPFNTHHNDLNMTLALRIATELPLKELVIGGIHKVYELGRQFRNEGIDLTHNPEFTTCEYYEAFTDVYDVMERTEELVEGMVKYVTGGLQTKFTTVDGEEYDVNWAKPWKRVEMIPALEEACGEKFPPGDQLHTAETNEFLKRMLKKTGIECSPPLTNSRIIDKLVGEFIEEKCINPTFITGHPQVMSPLAKYHRSQPGICERFEAFVCKKEIVNAYTELNDPFDQRLRFEEQANQKAQGDDEAQPLDEGFLNALEYGLPPTGGWGMGIDRMVMFLTNHYSIKEVLTFPFMKDEIQAPKPKAAEVTGVEPVPVEGVTHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1QHR4</accession>
    <name>N1QHR4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase</fullName>
            <ecNumber evidence="4 12">5.3.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">5-proFAR isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 12">Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_149801</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:15469"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="5.3.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the HisA/HisF family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.16" evidence="4 12"/>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760115.1">
        <property type="nucleotide sequence ID" value="XM_016905776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QHR4"/>
    <dbReference type="STRING" id="692275.N1QHR4"/>
    <dbReference type="GeneID" id="27902913"/>
    <dbReference type="eggNOG" id="KOG3055">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065050_0_0_1"/>
    <dbReference type="OMA" id="IEWNKTH"/>
    <dbReference type="OrthoDB" id="446074at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00009"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003949">
        <property type="term" value="F:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04723">
        <property type="entry name" value="HisA_HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000110">
        <property type="entry name" value="1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011858">
        <property type="entry name" value="His6/HISN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044524">
        <property type="entry name" value="Isoase_HisA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02129">
        <property type="entry name" value="hisA_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090">
        <property type="entry name" value="1-(5-PHOSPHORIBOSYL)-5-[(5-PHOSPHORIBOSYLAMINO)METHYLIDENEAMINO] IMIDAZOLE-4-CARBOXAMIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090:SF2">
        <property type="entry name" value="1-(5-PHOSPHORIBOSYL)-5-[(5-PHOSPHORIBOSYLAMINO)METHYLIDENEAMINO] IMIDAZOLE-4-CARBOXAMIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8 12 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF11994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="259" mass="28106" checksum="4FFAC6D367634B84" modified="2013-06-26" version="1">MTQFRPCIDLHAGSVKQIVGGTLSTDNTGLKTNFTSEHPSAYYAELYKKHNLRGGHVIMLGPGNDEAAREALAVWPGGLQIGGGIKDSNAKQWIDAGAERVIITSFLFPSGSFALDRLQSVLAALDGDKEKLVIDLSCRRVGQGWRVAMDRWQTITEFEINQENITLLEPYCSEFLIHAADAEGLQAGIDEGLVKYLAEICTIPVTYAGGGRSIADLELVDRLSSGKVDLTIGSALDIFGGKGVTFEECCRWNQQARNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1QI11</accession>
    <name>N1QI11_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_146023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765012.1">
        <property type="nucleotide sequence ID" value="XM_016903406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QI11"/>
    <dbReference type="GeneID" id="27900543"/>
    <dbReference type="eggNOG" id="ENOG502T1CK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060357_0_0_1"/>
    <dbReference type="OMA" id="RDIRSRH"/>
    <dbReference type="OrthoDB" id="408152at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040632">
        <property type="entry name" value="Sulfotransfer_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978:SF4">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOTIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17784">
        <property type="entry name" value="Sulfotransfer_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109594" description="P-loop containing nucleoside triphosphate hydrolase protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF16891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="34927" checksum="6C7C52139CA2A199" modified="2013-06-26" version="1">MGASLSARGPMWTSLAAILAILLVTVHQLGQPPEGLKPKVFVLGLSKTGTTSIGDALERLGYRRLGWRDIRSRHSCHTWANGDLSALEDLTRYYDAFEDLPWPMVYREMAERFPSSKFVLSLRKDEDTWLRSMDKHMGRGEWMPYAQFFGATKFQGNEDTIRQSYRNHTQRVREYFQDKPERYMEMIIDDGDINWDVLCRVAQCPGGNVPTISFPKSNPASAWDMGLLQKSISFCRGWTITRMEEILAKYYYERDAKEVKALLRTLWKCYDFVERAYTELEFKIVAWFSPPLTTSSDRHIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1QI95</accession>
    <name>N1QI95_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-hydroxyisobutyrate dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_151629</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17681"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57700"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-valine degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.31" evidence="3"/>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757820.1">
        <property type="nucleotide sequence ID" value="XM_016906937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QI95"/>
    <dbReference type="STRING" id="692275.N1QI95"/>
    <dbReference type="GeneID" id="27904074"/>
    <dbReference type="eggNOG" id="KOG0409">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035117_6_1_1"/>
    <dbReference type="OMA" id="MGKKVWH"/>
    <dbReference type="OrthoDB" id="21615at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008442">
        <property type="term" value="F:3-hydroxyisobutyrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000006">
        <property type="entry name" value="3-hydroxyisobutyrate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981:SF7">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0101">Branched-chain amino acid catabolism</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="8">
        <location>
            <begin position="41"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="9">
        <location>
            <begin position="219"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF09699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="357" mass="38034" checksum="71D7FE9DEBAE2AEF" modified="2013-06-26" version="1">MTTTTRTIQAARHAVSSATLAGPLSSSRRSFTTATRLHTSYGFIGLGRMGYPMAKNLRTKIKPDDTMIIHDVNEQITKQFVDEMGSVGPVTAAQDVREVAENSSTILTVLPEPHHVQNVFRNMLRPPTLLNNAQPIHSERLFIDCSTIDVRSSAEVSNATFSSGQGKFVDAPMSGGVVGAAAGQLTFMMGAAPELVDRATEILLMMGKRVVHLGPQTSGLKGKLANNYLLALNNIATAEAMNMGVVWGLDPKALADMINTATGKCWPSEVNNPHPGVVEGAPAGRGYEGGFGTALMLKDLKLAMQACAESAITPRLGTHAKDIYAAVEGTPELQGKDFSVVYQYIGGKATDDEKTSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>N1QIM4</accession>
    <name>N1QIM4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Arginine biosynthesis bifunctional protein ArgJ, mitochondrial</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="9">Glutamate N-acetyltransferase</fullName>
                <shortName evidence="9">GAT</shortName>
                <ecNumber evidence="9">2.3.1.35</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="9">Ornithine acetyltransferase</fullName>
                <shortName evidence="9">OATase</shortName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="9">Ornithine transacetylase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="9">Amino-acid acetyltransferase</fullName>
                <ecNumber evidence="9">2.3.1.1</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="9">N-acetylglutamate synthase</fullName>
                <shortName evidence="9">AGS</shortName>
            </alternativeName>
        </domain>
        <component>
            <recommendedName>
                <fullName evidence="9">Arginine biosynthesis bifunctional protein ArgJ alpha chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="9">Arginine biosynthesis bifunctional protein ArgJ beta chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_149976</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-glutamate + acetyl-CoA = N-acetyl-L-glutamate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(2)-acetyl-L-ornithine + L-glutamate = N-acetyl-L-glutamate + L-ornithine</text>
            <dbReference type="Rhea" id="RHEA:15349"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
            <dbReference type="EC" id="2.3.1.35"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine and N-acetyl-L-glutamate from L-glutamate and N(2)-acetyl-L-ornithine (cyclic): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="9">The alpha and beta chains are autoproteolytically processed from a single precursor protein within the mitochondrion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the ArgJ family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.35" evidence="9"/>
    <dbReference type="EC" id="2.3.1.1" evidence="9"/>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760395.1">
        <property type="nucleotide sequence ID" value="XM_016905887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QIM4"/>
    <dbReference type="STRING" id="692275.N1QIM4"/>
    <dbReference type="GeneID" id="27903024"/>
    <dbReference type="eggNOG" id="KOG2786">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027172_1_0_1"/>
    <dbReference type="OMA" id="WGRIVMA"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:L-glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004358">
        <property type="term" value="F:L-glutamate N-acetyltransferase activity, acting on acetyl-L-ornithine as donor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006592">
        <property type="term" value="P:ornithine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02152">
        <property type="entry name" value="OAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.340:FF:000002">
        <property type="entry name" value="Arginine biosynthesis bifunctional protein ArgJ, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.70.12:FF:000002">
        <property type="entry name" value="Arginine biosynthesis bifunctional protein ArgJ, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2330.10">
        <property type="entry name" value="arginine biosynthesis bifunctional protein suprefamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.340">
        <property type="entry name" value="ArgJ beta chain, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.70.12">
        <property type="entry name" value="L-amino peptidase D-ALA esterase/amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01106">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002813">
        <property type="entry name" value="Arg_biosynth_ArgJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042195">
        <property type="entry name" value="ArgJ_beta_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23100">
        <property type="entry name" value="ARGININE BIOSYNTHESIS BIFUNCTIONAL PROTEIN ARGJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23100:SF0">
        <property type="entry name" value="ARGININE BIOSYNTHESIS BIFUNCTIONAL PROTEIN ARGJ, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01960">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="DmpA/ArgJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 9" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="5 9" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="6 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_5023342614" description="Arginine biosynthesis bifunctional protein ArgJ alpha chain" evidence="9">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023342615" description="Arginine biosynthesis bifunctional protein ArgJ beta chain" evidence="9">
        <location>
            <begin position="237"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="291"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="517"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="522"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="9">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="9">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="9">
        <location>
            <begin position="236"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF12274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="522" mass="55974" checksum="80299DE7EE8E1A92" modified="2013-06-26" version="1">MAPKGTAAKRLLAAAVQVRTYSAPADRSIPAAKQKYVPTSGTYPKGFLAGSAFAGVKASNTKYDDLALVVSEEPCPATAVFTQNIFKAAPVQVSQKILSARRSQLSQGFRGVVVNSGCANAVTGVRGREDAEHMARVTDSAFGSTGDSNVPSTLVMSTGVIGQKLPIEKITNAIPTLKSNIGSTHEHWLNAANAICTTDTFPKLLSRQFTLPSHPDTTYSIAGMTKGAGMIHPNMATLLAIVCTDAKIDGESMNRLLKATVSQSFNSISIDGDTSTNDTLAFFANGAAAPVGSSPIQYSSPKRAPASEGGRRLSAEPQPVDMIALEKVLSSFLKDLAKLVVRDGEGATKFVTIRVRSDVSLNTAKRAAISIARSALVKTALYGKDANWGRILCAIGYAPGIMSTKEVNTRDLMSGMMGRMKTKTPYDKIPQVTPACTSVSFIPTDGTKELQLLVRGEPQDVDEFRAKEILEMEDLEILVRLEDRDGDVATELNKPQRKVHEAVFWTCDFSHEYVTINGDYRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1QIN3</accession>
    <name>N1QIN3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_69582</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758565.1">
        <property type="nucleotide sequence ID" value="XM_016909867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QIN3"/>
    <dbReference type="GeneID" id="27907004"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006937_7_1_1"/>
    <dbReference type="OMA" id="WNTGGCT"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF4">
        <property type="entry name" value="FAD_NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF10444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="618" mass="69386" checksum="F997B88CA9BB96C4" modified="2013-06-26" version="1">MAGEEDQHRRRHGEATVVIIGGGISGICVAIDLLKRNNCRDFVILEKSAGVGGTWLDNKYPGCCCDVWSALYSLSFAQNPNWTREYPGQEEILAYLTDVAQEYKLYPHFRFNSSVTGATWDTETKKWLVHVSTAAGSKEAEFHASYTLQADFLVSAVGQLNIPKYPSAASIPGIEEFTGKKMHSARWDWSYNFRDKKIALIGNGCTAVQILPELVAGGAKSVTLFQRTPNWVVPRGDGPVSPLWRNIYKYIPGVLARKRATQMDFREEQFQFINYSNPEMAEAYMAAHREKLRENLPDRKDLWEKLTPKYGLGAKRLIISDDYFPTLARENVFLETRGIERIEGRRILVRDEEEEGSETKIVDSLPSSSSSSSSDDDDGFDLLICATGFLTTSFLHPLTLTGPSGIPLSSTWSSTSSAGPQALYGITVPSLPNFAMLYGPNTNLGHNSIILMIEAQSRYINALIRVILDAKRQGGVVTTLRPREDVTERYYEMIQKELRNSVFWDEKVESWYKNDQGVIVNNFSRSVVEYQKLVEKVDLGEFEVEEWGFEKGEGDGDDKKKKVARREGKKNDEIVYVGRVREETVVSDRMLMVMGVVSTVAVAGAWAVRRLGGLQRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1QIW1</accession>
    <name>N1QIW1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MOSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_117725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016901367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QIW1"/>
    <dbReference type="STRING" id="692275.N1QIW1"/>
    <dbReference type="GeneID" id="27898504"/>
    <dbReference type="eggNOG" id="KOG2362">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028286_3_1_1"/>
    <dbReference type="OMA" id="INDDWSE"/>
    <dbReference type="OrthoDB" id="17255at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOCOS_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141673">
        <property type="entry name" value="MOSC N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="2">
        <location>
            <begin position="145"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF11755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="346" mass="38458" checksum="195A8E33C6037783" modified="2013-06-26" version="1">MKIKRIFIYPVKSLRPVEVNAAEITNEGLRFDRQYVLAKPPTEETNGLAEHITIKNHFELGLFHTMIDQSWAKLTITHVHAEERAAVTVPLTPSPVSLFNADVFHVSIFGTKAQGIDMGTEASEYFSHHLGKPVRLLYIGGNGQREIPGAVFMPKHKYRALSIAVNDKLQPQRVRFADAAPLLITSSASEEDARQRLPPSARGEDLIVRFRPNIHVDVGGEVEPYDEDRWDLLTIRSKMDSAQEVSVRCLFRTVRCLSLNADLAKGSMITTNRQLYGLLAKDRRVNELFPHKPVFGQYACAGPSGAVLRVGDHVEVSGRVDHPISPMSAGSPITPITQDGNNHEDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJS7</accession>
    <name>N1QJS7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WHIM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_149843</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760181.1">
        <property type="nucleotide sequence ID" value="XM_016905805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJS7"/>
    <dbReference type="STRING" id="692275.N1QJS7"/>
    <dbReference type="GeneID" id="27902942"/>
    <dbReference type="eggNOG" id="ENOG502QSZU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023536_1_0_1"/>
    <dbReference type="OMA" id="HYGPQDI"/>
    <dbReference type="OrthoDB" id="349045at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028942">
        <property type="entry name" value="WHIM1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42107:SF1">
        <property type="entry name" value="WHIM1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42107">
        <property type="entry name" value="YALI0D24453P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15612">
        <property type="entry name" value="WHIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WHIM1" evidence="4">
        <location>
            <begin position="143"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="290"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="187"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="348"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="395"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="444"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="499"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF12060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="609" mass="67445" checksum="6E397FEBD1395E58" modified="2013-06-26" version="1">MDSDSDSSLSEVPEETVKQLAPIFQKAKKATKQAAPPPKASPPRPKRAPSPPHEEVLADNPDIAFLVMFRSRFTEIFPGKCPQFGPQDIERGVVDTVPSPEIQQLLCALLGLVLNRKKPVERTAYGRAIEEAVLSHKKEWPYKWAGQNPLHGGKDFNNMSPSERLNFLRTLVIWSLGSSEQVAGTIKEKYKQQRHSDDENQPLSVQPWGMDGDNRRYFLIQGLDDTSFRIYREGSRYTRNAHWYSQAGTIDEAKALAEKLEKEDGSQKARKLAIKITNAVPMFEATEEKRNRRIYRQQRRAAFTRPEPGFGIYEGRTRGKRTRYTYDDEGGDDSDNTSTRRSTRHQSARSTPFETGPQYTASGRQIKQPRQGDYGESLLSTNVMSTDELGPDNDTEARSGRADSQESDPVQSGGRPSRGNRNVNYADKNPRKRKHIDGYNDIDAMSEEDDAVSGDEWNSDQNDDEMPDAPDVDSEPSEDEDDGLDDVPKSLLVKLKIPQSASVQSRNTPPTSPSVSGEKDTALGCAPGPTDEKIASTTTNGEAKLEATKTSVLTEAPLALTSIDSLTPTSPRRSPQVVVPAYSAHAKFQNSYSTTSMLNGNGGHGGQIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJW2</accession>
    <name>N1QJW2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NTF2-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_146504</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765611.1">
        <property type="nucleotide sequence ID" value="XM_016903694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJW2"/>
    <dbReference type="STRING" id="692275.N1QJW2"/>
    <dbReference type="GeneID" id="27900831"/>
    <dbReference type="eggNOG" id="KOG0116">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022209_2_0_1"/>
    <dbReference type="OMA" id="RPRGNAY"/>
    <dbReference type="OrthoDB" id="339151at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990861">
        <property type="term" value="C:Ubp3-Bre5 deubiquitination complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034517">
        <property type="term" value="P:ribophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00780">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000003">
        <property type="entry name" value="Nuclear transport factor 2 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039539">
        <property type="entry name" value="Ras_GTPase_bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10693:SF20">
        <property type="entry name" value="AT27578P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10693">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="NTF2" evidence="5">
        <location>
            <begin position="72"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="437"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="192"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="388"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="510"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="203"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="239"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="289"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="418"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="522"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="547"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF17490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="575" mass="61204" checksum="998662EC0D701518" modified="2013-06-26" version="1">MAAEVTGLPNGNYGMHQSYGGGDQNSFGYASNNQNSQPPATTSNAPPSSSTPSNASANPQQPPQPDIPKDEVGWYFVEQYYTTLSRTPEKLYLFYNKRSQFVSGEETDKVAVCVGQRAINDKIRDLDFNDCKVRVTNVDSQASDSNIVIQVIGELSNRGQPHKKFTQTFVLATQTNGYFVLNDIFRYLVEDEEEAEAEPEVQPPQEEVQQVSGTQSGVQEPAPVAAHSAALTSSSDPAAVEHDAEEVDQKIEEKLANGTKPEAEEEPAAVEEEKAVEETPAAQSESESEPTKDVEKETATEAVAEPETPKDPEPTRIATPSKQDAPKTAPAPKPAAPAVPKTWASLAASAAKTVTPVIPQPVAQAAKSIQQKAAAAVPTAPAAAIANAITPNTPSAPSSQDAKGNDSQDEWTAVGGSHNRNASKQANVVPQQQEPQYRGYIKNVADNVEGAKLRAELEKFGEVTYFDIARQKNCAFVDFKTADAYNKAKATQFEVEGNDVPLFVEERKFRPGSTPYVPRGQYQGGRGGPRGGANQGPPRGNFQNGRGAPGGQGAPRGRGGYAAAGQRGGRGGVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1QK31</accession>
    <name>N1QK31_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_149916</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760291.1">
        <property type="nucleotide sequence ID" value="XM_016905853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QK31"/>
    <dbReference type="GeneID" id="27902990"/>
    <dbReference type="HOGENOM" id="CLU_2185597_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF12170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="109" mass="12347" checksum="2DFADF954D5CFF67" modified="2013-06-26" version="1">MPGHAFVENQGTLWYPWHGGKEPRKETDHPAEAADVKINNTVIIPRLRLQRHPSSITTAGHARKLRLHTSSYDLSSLSTRPSRPNVEELERGNLHGYCVADACRMPILW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKD1</accession>
    <name>N1QKD1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_66804</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759782.1">
        <property type="nucleotide sequence ID" value="XM_016909765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QKD1"/>
    <dbReference type="STRING" id="692275.N1QKD1"/>
    <dbReference type="GeneID" id="27906902"/>
    <dbReference type="eggNOG" id="KOG4344">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010106_0_0_1"/>
    <dbReference type="OMA" id="RTNQFEV"/>
    <dbReference type="OrthoDB" id="66546at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22572">
        <property type="entry name" value="GCP5_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059169">
        <property type="entry name" value="GCP5_N_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032797">
        <property type="entry name" value="Mod21_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF33">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14609">
        <property type="entry name" value="GCP5-Mod21_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-Tubulin ring complex non-core subunit mod21 N-terminal" evidence="8">
        <location>
            <begin position="65"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="9">
        <location>
            <begin position="219"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="605"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="133"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF11661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="810" mass="89685" checksum="2C651B4261149739" modified="2013-06-26" version="1">MAHAALLDKLTDGLVTALTGQTARDAGYRALKSQAVRGLRDKSHARTNQFAVKARLNGITEKLAVLNRDDLADALQERLEELPSSSKWTPELLSLFLDLSDCPASKTILSHVVVPEDDQNTRPQLTWEEIVADDPLDEPGVWDDVDRGYHSSADNSSDSELDSEPTVSTSATSVHEDLSAIARLHLSQPDMSITSPVHETLQNWKEDSGTCSLSELTLVREMLLMLHGLPTNLFSRDSSTGRVTMSRRMELATTSTTSVNDVVTSCVKLASALNYLRMWIRSSQSLLYMRAVQAELQKLLKVFDDGLVAMQRRYIEPHPKTVVSIVDVATEAHASAVPLVHLSSIVQVVALSTGQAQQLVMLDTLYDEACLAQVSGATASFLPIVRVFCAALRGYLRPIAAWTMFGRTEFNNHEISLVVVVEKDCALGHIWRQKYAENCAVDGSILVPNCLAANTSKLFALGKSRAFFRLLQPSSDDASTLQDTDLPNFESMQHQLAQHSLLLFPQLLDEELQSWITRIGNDCTPQLLNSLWHENYLSRTMAALPNVFFSADGVLFQDFASAVETRVIAKGESKAWNDQFMLAELARNTLGTCEEVDADCIQIHTPTGHTAPSTTRALDTFSLEYKFPWPIQNITGCSTSSTHAKVFAFLLQVHYAGSLLTKNFFSLRSGPQRSAPHVSLRQKLLWFTEIIHFFITSTARTIHQETLELMLNATDIDAMIAIWQDYDRRLQTNLLLPANLEPVRDTITGILELSELLARTTRAESVKTLLNQFNESLSILVAAIRGLSRAGGAEMAMETLAERLEWSGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1QL83</accession>
    <name>N1QL83_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GrpE protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_145635</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the GrpE family.</text>
    </comment>
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        <property type="protein sequence ID" value="EMF16378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016903173.1"/>
    </dbReference>
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    <dbReference type="STRING" id="692275.N1QL83"/>
    <dbReference type="GeneID" id="27900310"/>
    <dbReference type="eggNOG" id="KOG3003">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057217_0_0_1"/>
    <dbReference type="OMA" id="PHRHQAI"/>
    <dbReference type="OrthoDB" id="201635at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="F:protein homodimerization activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:protein import into mitochondrial matrix"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.22.10:FF:000002">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="GRPE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237:SF23">
        <property type="entry name" value="GRPE PROTEIN HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
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    </dbReference>
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        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
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        <location>
            <begin position="95"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="9"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF16378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="250" mass="28165" checksum="93CC04141AA7C896" modified="2013-06-26" version="1">MLQQRIARSLQTLARPSQSSRIARTATTTPWRSSYKAPAVASQSIAARRCYSSAKEESDKKQEQILKEEGKGTQDTATEGAAAAAKEENPLQKELEAVKKENLDITDRLKRQIAEYRNLQEQTKREVKAAKDFALQRFAKDLLDSVDNLDRALENVPKDKLTPENQDLVNLHDGLKMTDEILVKTLKRHGMERIDPSVEGEVFNPNLHEATFQAPQPDKKDGTVFFTQQKGFMYNGRVLRAAKVGVVRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1QLA5</accession>
    <name>N1QLA5_SPHMS</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_117932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EMF11981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016901386.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="27898523"/>
    <dbReference type="HOGENOM" id="CLU_2051114_0_0_1"/>
    <dbReference type="OrthoDB" id="3645838at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF11981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="120" mass="13073" checksum="D35E06E67EFB5987" modified="2013-06-26" version="1">MPSPSDRREGANSATTHHCQPRQASKAQDIRRKMPSTASSTASSTRSSSLNTSSCTTHAHQYLGDNKASDIASWTATVPAKTTNPNGVLYDEVDPTVQAYMQMKMALFQSMSRPKQDIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1QLV2</accession>
    <name>N1QLV2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_145530</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SDE2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764340.1">
        <property type="nucleotide sequence ID" value="XM_016903110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QLV2"/>
    <dbReference type="STRING" id="692275.N1QLV2"/>
    <dbReference type="GeneID" id="27900247"/>
    <dbReference type="eggNOG" id="KOG2827">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060603_0_0_1"/>
    <dbReference type="OMA" id="RAPWIQN"/>
    <dbReference type="OrthoDB" id="547031at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051421">
        <property type="entry name" value="RNA_Proc_DNA_Dmg_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053822">
        <property type="entry name" value="SDE2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024974">
        <property type="entry name" value="Sde2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786">
        <property type="entry name" value="SPLICING FACTOR SF3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786:SF1">
        <property type="entry name" value="SPLICING REGULATOR SDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22782">
        <property type="entry name" value="SDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13019">
        <property type="entry name" value="Sde2_N_Ubi_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sde2 ubiquitin" evidence="10">
        <location>
            <begin position="8"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="SDE2-like" evidence="11">
        <location>
            <begin position="94"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="102"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="216"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="229"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF16219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="299" mass="32554" checksum="CF136E4C2586D87B" modified="2013-06-26" version="1">MADMEPTINVLLTTFAGLGLPRTLSLPTKASTPISSVYSTIQSRLPSSTTDDGLLITTVSNKQLLPHNESPLTSLLSSPNDTILSLRLSRRLCGGKGGFGSQLRAAGGRMSSRKNRNSNVNPNASNRNLDGRRLRTVDEAKKLADYLAIKPEMEKKEREERKKRWQEVVDAAERREEEIKGGKAGASKGRLDAEWVEGKEEVENKTREAVVRAMREGLLEQITGSESSAEAEDSEDEDAEQSSGSSDGVEAEAPNTAADGGRSFFGWDDDDDEDDDEDSEDDEVTEEAYEGKGKGKANV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1QMD7</accession>
    <name>N1QMD7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_112606</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764685.1">
        <property type="nucleotide sequence ID" value="XM_016900988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QMD7"/>
    <dbReference type="STRING" id="692275.N1QMD7"/>
    <dbReference type="GeneID" id="27898125"/>
    <dbReference type="eggNOG" id="KOG0143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010119_4_0_1"/>
    <dbReference type="OMA" id="TYIRNSH"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="193"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF16564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="353" mass="39462" checksum="E9A8168629AE54D1" modified="2013-06-26" version="1">MPHKEQQHVEFVPEDYPPFPADLKTIDLQTISLQKIQNADSAEQDRMFAACKNWGFFYLDLTQSDQGELISQGAAQVARVAEGVMALPLEEKEQYPFTDGNIFGYKKVGQTKVDKDQTPDTAEFFNVSKNDMIVPDAQMKRKWPNIIVENKGLLSTYCKTAHSVGVQILGILASKLGIDPEEIFQRHTIEKFSGDHIRMTRGPPRKTAEMPEIQTPSHTDFGTITILMNWLGGLQVLGSPNRILGNLDFADDNNNGEWLWVKPKKNCAIVNLGDAAVKFTNGVLCSGRHRVIPAPGSQGQWPRYSIVYFVRPIDECKLKTLKGTGVPEAGDEDEDGINAREWIFTQAEKLAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1QME8</accession>
    <name>N1QME8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_138188</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765628.1">
        <property type="nucleotide sequence ID" value="XM_016902869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QME8"/>
    <dbReference type="STRING" id="692275.N1QME8"/>
    <dbReference type="GeneID" id="27900006"/>
    <dbReference type="HOGENOM" id="CLU_2321831_0_0_1"/>
    <dbReference type="OrthoDB" id="3650438at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF17507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="99" mass="11031" checksum="C601F1B3B72928E2" modified="2013-06-26" version="1">MFLEHGADVHRGDVMFFATGPKRAVEVTRVLLCKGADPNRLRFDGLEPGYRLDLVLALLKGGADVNVKDTLGRTPRMLAELRRESEVLVLLFARKQGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1QMR8</accession>
    <name>N1QMR8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lytic polysaccharide monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_35015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765778.1">
        <property type="nucleotide sequence ID" value="XM_016908589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QMR8"/>
    <dbReference type="STRING" id="692275.N1QMR8"/>
    <dbReference type="GeneID" id="27905726"/>
    <dbReference type="eggNOG" id="ENOG502S005">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032571_2_3_1"/>
    <dbReference type="OMA" id="QHANSWI"/>
    <dbReference type="OrthoDB" id="2342176at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182:SF2">
        <property type="entry name" value="LYTIC POLYSACCHARIDE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004111006" description="Lytic polysaccharide monooxygenase" evidence="1">
        <location>
            <begin position="22"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF17657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="207" mass="22051" checksum="FB0FC6EEA81E5263" modified="2013-06-26" version="1" fragment="single">MFSGTGFLALVALALLDQTFAHMTLKTPVPYGIDTLDTSPLLNLAISDPQSNYPCKQRAGVYDVSVQNKIPVGVPQELTFGGSASHGGGTCQISVSLDKEPTKSSVFKLIQVFEGGCPTAGEGNDGSDKFTFTVPKGFPNGDFALAWTWYNKVGNREIYMNCAPITVTGGADNNDVYDSLPNQYLINLPTSECSTVETSDQIIPNPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNQ8</accession>
    <name>N1QNQ8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Patatin-like phospholipase domain-containing protein</fullName>
            <ecNumber evidence="7">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_146868</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Lipid hydrolase.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Probable lipid hydrolase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PLPL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="7"/>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016766099.1">
        <property type="nucleotide sequence ID" value="XM_016903921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNQ8"/>
    <dbReference type="STRING" id="692275.N1QNQ8"/>
    <dbReference type="GeneID" id="27901058"/>
    <dbReference type="eggNOG" id="KOG2214">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009031_2_1_1"/>
    <dbReference type="OMA" id="CSWFTRG"/>
    <dbReference type="OrthoDB" id="15478at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990748">
        <property type="term" value="P:cellular detoxification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006642">
        <property type="term" value="P:triglyceride mobilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07232">
        <property type="entry name" value="Pat_PLPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021771">
        <property type="entry name" value="Triacylglycerol_lipase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF66">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE PTL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11815">
        <property type="entry name" value="DUF3336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5 6 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="9">
        <location>
            <begin position="321"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="84"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="663"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="753"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="816"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="6">
        <location>
            <begin position="352"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="95"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="757"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="790"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="354"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF17978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="843" mass="95655" checksum="3F6C9AF295EE78C4" modified="2013-06-26" version="1">MADPDVRTDGIAVTSPEAWDYKTLPEWDNDFYEEDDILQFAAALDAPSNALAASPSEEDLSRLEKTKEAERITALNDWRPVRQRQLRRPGASRSRASRKSSKSRHKKQARRGRDETREGWTYSFAKYPLLLFIFGWIGFLGTCYAFTRLYIWFYEQYVTWRGQRDRLRKALRKQDHYEGWVKAAEELDRHLGNDKWKADDEGSYYDWKMIKQVLRQLQHLRKQAEEDERSSRGRTGGRESGERPIDLLRKVLESCVKANFAGIENPRLYSETYYGTKNLLQSYIDETSMALKYIFSSSQLTPADKRTLSDRLSANLGRSALCLSGGATFAYYHFGIAKSLLDADILPPIITGTSGGAVVAALLCTRTDEELKKLLIPALATRITACHESIRIWWFRYWRTGARFDSVDWAKRCAWFCRGSLTFKEAYQLTGRILNVSTVPSDPHSPAILANYVTAPDCVIWSAVIASAAVPGILNPVVLMRKLPSGKLEPFSFGHKWKDGSLRTDIPLKSLNTHFGVNFSIVSQVNPHVSLWFFSNRGTVGRPVTHRRGRGWRGGFFGSAIEQFIKLDLNKWLKVLRHLELLPRPMGQDWSEVFLQRFSGTITIWPKTCMSDFWNILTDPTMDRLARQITAGQLATWPKLKFVSNRMALEKVIRDAYTQYHAPDEEPPVVAPSHSPDQPSPLSPPRALRSVLSEDDLTSLLAQAKANNGVVEVPENLLTPGREVDRFNFASTSSVERQESPSLAKRMSNLWGAMQTSPNNSNNNSTSRSSIETVRPSPRELAVPSPSSHHAREQSRRRSNVVDELVRQSRVFFDDDDDILFGSETDGDADGRSDTEYETTGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNV1</accession>
    <name>N1QNV1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor IIF subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">TFIIF medium subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">TFIIF-beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_146621</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIF beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765780.1">
        <property type="nucleotide sequence ID" value="XM_016903772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNV1"/>
    <dbReference type="STRING" id="692275.N1QNV1"/>
    <dbReference type="GeneID" id="27900909"/>
    <dbReference type="eggNOG" id="KOG2905">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047858_0_2_1"/>
    <dbReference type="OMA" id="ANCPEHQ"/>
    <dbReference type="OrthoDB" id="26094at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005674">
        <property type="term" value="C:transcription factor TFIIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07980">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000035">
        <property type="entry name" value="General transcription factor IIF subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003196">
        <property type="entry name" value="TFIIF_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040450">
        <property type="entry name" value="TFIIF_beta_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040504">
        <property type="entry name" value="TFIIF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011039">
        <property type="entry name" value="TFIIF_interaction"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02270">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17683">
        <property type="entry name" value="TFIIF_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50916">
        <property type="entry name" value="Rap30/74 interaction domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIF beta subunit N-terminal" evidence="12">
        <location>
            <begin position="35"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIF beta subunit HTH" evidence="11">
        <location>
            <begin position="252"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="338"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00081473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF17659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="361" mass="41233" checksum="ED452E7D5547A2E0" modified="2013-06-26" version="1">MADLKTEIKAEETKPLGEIDEFEEDNDLQMPPDGSKSWLLKVSEDMWKVWNDVYANAPDDQQIEIGSVRVFHHGPSDTKQKIQIRLRDNIEQHAPLPKTYNVELKTERYNNTVIFSEKDLPGHNSNARPNRIPPSQRPGGINKFDRYHNNYGGGSQQPRKPGTYRTSIPKQTALAPMIANEFDMHPVEDQSSLDYFAESYRNALNAGNKTTFVNSQRVRHPGQDNESFVFGTLTSKVGGAGNKKKAIKEKAVRMEKAALLDALKMCFKEYTYWSLKALRQRLRQPEAYIKETLDEIATLMRQGDFVQNYKLKPEYKMLMEEGGEDMSGVKEELAVAKLETTDEGTGDELDEDDEFEDVKME</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNV3</accession>
    <name>N1QNV3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_146627</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SO2202</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2012-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genome evolution in poplar pathogens from wild and recently domesticated pathosystems.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Dhillon B."/>
                <person name="Feau N."/>
                <person name="Sakalidis M.L."/>
                <person name="Gill N."/>
                <person name="Aerts A."/>
                <person name="Ohm R."/>
                <person name="LaButti K."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Copeland A."/>
                <person name="Beauseigle S."/>
                <person name="Grigoriev I.V."/>
                <person name="Goodwin S.B."/>
                <person name="Tanguay P."/>
                <person name="Hamelin R.C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765790.1">
        <property type="nucleotide sequence ID" value="XM_016903775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNV3"/>
    <dbReference type="STRING" id="692275.N1QNV3"/>
    <dbReference type="GeneID" id="27900912"/>
    <dbReference type="eggNOG" id="KOG1577">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_0_0_1"/>
    <dbReference type="OMA" id="ITQYSPF"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000007">
        <property type="entry name" value="NAD(P)H-dependent D-xylose reductase xyl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="6">
        <location>
            <begin position="46"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="5">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF17669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="340" mass="38135" checksum="07910CE3A943D7FC" modified="2013-06-26" version="1">MASRFQPQTAIKRAQQVTSHINPRTQFRMASTTHLKLNTGATIPALGFGTWQDKDAQEDAVYLALKAGYRHIDTARIYGTEPAVARGIKKSGVPRDQIFITTKLWNNSHDPKSVEKALDASLKDLDTDYVDLYLMHWPSPFKDGDDMFPKEDGKTLTGNSDFVDTYKAMEQLQKKGKARAIGVSNFSQGELERLIKETSIVPAAHQIECHPYLQQASFAAYHKQQGIHITQYSPFGNSNEIYSSGKEIPKLIEDPTLVEVGKKYNKSGAQTALAWGIAHGRSVIPKSKTESRIKQNLEGDFKLEAEDVKKIDSIDKKLRFNDPSANFGWNFYSDLDGKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNY8</accession>
    <name>N1QNY8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">CBD9-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_146773</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765965.1">
        <property type="nucleotide sequence ID" value="XM_016903857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNY8"/>
    <dbReference type="STRING" id="692275.N1QNY8"/>
    <dbReference type="GeneID" id="27900994"/>
    <dbReference type="eggNOG" id="ENOG502SJ74">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031471_0_0_1"/>
    <dbReference type="OMA" id="RWHWINQ"/>
    <dbReference type="OrthoDB" id="19261at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd09630">
        <property type="entry name" value="CDH_like_cytochrome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1210">
        <property type="entry name" value="Cellobiose dehydrogenase, cytochrome domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015920">
        <property type="entry name" value="Cellobiose_DH-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797:SF1">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05805)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16010">
        <property type="entry name" value="CDH-cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00664">
        <property type="entry name" value="DoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50836">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004111036" evidence="9">
        <location>
            <begin position="18"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="DOMON" evidence="10">
        <location>
            <begin position="41"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="11">
        <location>
            <begin position="209"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="463"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="484"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF17844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="501" mass="55124" checksum="4D54F5FC6E7EFA01" modified="2013-06-26" version="1">MRSIILILLASLQLAWTADRQQMTQAGIDEHAKAAYFVLRSSGYVFALNVAENGDVYFHMNAPARHSWVGVGFGSSMHNTRMIVSYISEDGHRITNSPRMSRGQVEPEWEQDVVIDDVQSDLYAPYANTLSPDGIMIAHAVCRNCSTWATGSIDTTSTSQPFIFALGPNITLRSNELDAPLRLHDFHGSFELDMTVATNISGSYGRVPPPQDPGLQVGHAYWAFANYFSSNAYSTGHDKEWAQIVHAVFMCLAFLLVFPLGAITLRLVRRAPVHAAVQTFGLGLVVVGFALGVYASKLYNKSKNFNSAHQIIGLAVFAAIFLQIGLGLSHHLIYMRSGLPTILGKIHRVLGISILVLGVVNGGIGLDFAGSSVVGYVIAVTIMTVIFGAISATIYFYNRHHVYRPESQPFTAPKDPADEYEMHQAPFATMGQTGYVQTPRTPFFGAVKAASWDDDPEDYRTYVQRGGDFKGGMERQMSYTDTPASDRENPFKTKWESGSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2024-01-24" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M3AQX7</accession>
    <name>M3AQX7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_121786</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EMF07874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016755995.1">
        <property type="nucleotide sequence ID" value="XM_016901730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AQX7"/>
    <dbReference type="STRING" id="692275.M3AQX7"/>
    <dbReference type="GeneID" id="27898867"/>
    <dbReference type="HOGENOM" id="CLU_1994040_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF07874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="125" mass="14557" checksum="39F1BAEFA1487FCC" modified="2013-05-01" version="1">MPKRKSNALEALANKRAKLGAASKSLEEYSLKPNTLRDRERTAAMDEEKRAQDRYRKARNESFARFKKELIEGWRKIHTKEYNQKATKKQTGKSATLPPDKQAKIDEADWFLELGNIDSKERLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M3ARA1</accession>
    <name>M3ARA1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_121505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF07994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756115.1">
        <property type="nucleotide sequence ID" value="XM_016901690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3ARA1"/>
    <dbReference type="GeneID" id="27898827"/>
    <dbReference type="HOGENOM" id="CLU_1714435_0_0_1"/>
    <dbReference type="OrthoDB" id="10632634at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF07994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="153" mass="17214" checksum="AC21F6ED779B856B" modified="2013-05-01" version="1">MSPRKFFSNGGRGNDSGIRKVAATAVEEVEEQRKEWYDSASTTEYVAVASKGSTTKVQTTRAGSMRSSSPSREHSLSWVTLPFSWARPKASVRDRDILDKSQKAAVARTKRGSDKEKRRSEKEAAREAEGGKKEWPEHLKWYYGANIPGYWVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M3ASJ2</accession>
    <name>M3ASJ2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heme-dependent catalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_152116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756585.1">
        <property type="nucleotide sequence ID" value="XM_016907254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3ASJ2"/>
    <dbReference type="STRING" id="692275.M3ASJ2"/>
    <dbReference type="GeneID" id="27904391"/>
    <dbReference type="eggNOG" id="ENOG502SH70">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046417_2_0_1"/>
    <dbReference type="OMA" id="LSFNPWH"/>
    <dbReference type="OrthoDB" id="3358373at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36195:SF4">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G01990)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36195">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G01990)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF08464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="413" mass="47359" checksum="87D5CC860D8DA323" modified="2013-05-01" version="1">MVNYHLTTKSIFTPASLLPSHKRTPSSHSCQERKKSLKVDMSTTASATSDDLSHRQYLRWDTKGVEDPPPGEQEDIKAVAEQINTQQRQQFDHHRHVYTGTHCRTHGIVKGTFTVHDALPPHLRQGELFAQPGSFPAACRYSTEPGDPGFPDTIPTPRGFSIKLFNVKGDFLPTGADGAHPPTQDIEFNSTPAIELADAKTTREIFNIRMGLGTLLDTKEMNQELEKRKDTELQKGRFQVPNPHLASLRQYSQTAYRFGDYVFKYCLVPNTATQEKLADQTIRPDTDATDQHHKWLQNFHQNHDAEYLFQVQLLENLDEQPVEYSGKEWDSSKYPWQTVATLQIPKQEAFDLERKAFWEDHMRLDPWHGLKAYQPLGGSNRLRKVVYPASSKLRRQMNGRKEIWVKSIDEIPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M3ASQ8</accession>
    <name>M3ASQ8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_152176</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756660.1">
        <property type="nucleotide sequence ID" value="XM_016907285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3ASQ8"/>
    <dbReference type="STRING" id="692275.M3ASQ8"/>
    <dbReference type="GeneID" id="27904422"/>
    <dbReference type="eggNOG" id="ENOG502S9EF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_909510_0_0_1"/>
    <dbReference type="OMA" id="LDQYHKP"/>
    <dbReference type="OrthoDB" id="5425782at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004031777" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="25"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF08539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="33601" checksum="7F536DE7D4CBE71D" modified="2013-05-01" version="1">MTPPVAPAAAVMLSFLLGFAQIDAEEIPGGIVPNKRQAVGTGVTTTASETQSTTMSTPSTSATDVDSTTESTPAAPSTTQNPTTPTTETTVAAPTAPTTSSAPAPSPSPSTPANTTPTSDATTETTTQPAPSPSTSTVPTTIEVTTTNSAGSVVTSRITSSIIAVASPTSSSDAVVNLGSTTINRSTLSSNLVITRPFTTSATVASTYTSYFTQDGTLASAVFTTQQVLATTGVATSTISPDLQGGGSGGGGGGLSSSSKSIIGGVVGGVGGAILVGGIAIVAWRLWGKKKQRAVGQHSYNDSMDHSLQKGESSPAQLAGGTGLERYQQPHVNTASNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M3AU07</accession>
    <name>M3AU07_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAM1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Outer kinetochore protein DAM1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SEPMUDRAFT_151847</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757080.1">
        <property type="nucleotide sequence ID" value="XM_016907077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AU07"/>
    <dbReference type="STRING" id="692275.M3AU07"/>
    <dbReference type="GeneID" id="27904214"/>
    <dbReference type="eggNOG" id="ENOG502S08R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083960_0_0_1"/>
    <dbReference type="OrthoDB" id="5586015at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990537">
        <property type="term" value="C:mitotic spindle polar microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990758">
        <property type="term" value="P:mitotic sister chromatid biorientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013962">
        <property type="entry name" value="DASH_Dam1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28113">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28113:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08653">
        <property type="entry name" value="DASH_Dam1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="91"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="128"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMF08959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="187" mass="19538" checksum="C5042C780B59B2EA" modified="2013-05-01" version="1">MADLEANMMHLQLLNDSLSRFSENFGAFLYGMNMTAFCVDFPEAPLKESYARHKDTQGRDQMEDSPFRGYEGYGGQGRGREGDMEATFMTSDTSGFVENPEPSTVKKSGGSSKFSEVPGSLSTPGKFAGRGRGGVGTGRGGAGTRGNATATAGRGRGSGIARGSSTARGSTRGTGIARGIARGRGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M3AW39</accession>
    <name>M3AW39_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carboxymuconolactone decarboxylase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_151287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758427.1">
        <property type="nucleotide sequence ID" value="XM_016906719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AW39"/>
    <dbReference type="GeneID" id="27903856"/>
    <dbReference type="eggNOG" id="ENOG502SNP7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082760_2_0_1"/>
    <dbReference type="OMA" id="NAVYEWN"/>
    <dbReference type="OrthoDB" id="9998495at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34846">
        <property type="entry name" value="4-CARBOXYMUCONOLACTONE DECARBOXYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34846:SF11">
        <property type="entry name" value="4-CARBOXYMUCONOLACTONE DECARBOXYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF10306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="207" mass="22518" checksum="3B2B85C50A541512" modified="2013-05-01" version="1">MRIPYAPSTPPATSPPSTSEIYSRIAARRAPRPLIPLDLALLHNPAIADGYNSLMGAIRTQSSFPLHLAELAICYIAVLNGAVYEWTAHSKIYLKADGGRREVLKALLELKGKSVDGNSSSSGDNAGSGAVLSEDEQDVLRFTEQSTKHVNVDEELVERLKGKFTDQQVMELMITVAGYNMVSRFLVGLDVTESNGKEMVMPPEEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M3AZE7</accession>
    <name>M3AZE7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome b5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_149431</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761013.1">
        <property type="nucleotide sequence ID" value="XM_016905545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AZE7"/>
    <dbReference type="STRING" id="692275.M3AZE7"/>
    <dbReference type="GeneID" id="27902682"/>
    <dbReference type="eggNOG" id="KOG0537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102602_4_4_1"/>
    <dbReference type="OMA" id="AWVIIQG"/>
    <dbReference type="OrthoDB" id="260519at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359:SF14">
        <property type="entry name" value="CYTOCHROME B5 A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="6">
        <location>
            <begin position="2"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF12892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="84" mass="9403" checksum="9B1D79D6BE60AA2F" modified="2013-05-01" version="1">MSKQFTANEVKEQGSVEKGLHIIIDNNVYKLDTFVDEHPGGAKILKRVGGKDASKQFWKYHNESVLKKYGGKLKVGEVKEAAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M3AZY0</accession>
    <name>M3AZY0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ClpP/crotonase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_83584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761208.1">
        <property type="nucleotide sequence ID" value="XM_016910337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AZY0"/>
    <dbReference type="STRING" id="692275.M3AZY0"/>
    <dbReference type="GeneID" id="27907474"/>
    <dbReference type="eggNOG" id="ENOG502QS1J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_3_1_1"/>
    <dbReference type="OMA" id="SIVCTNP"/>
    <dbReference type="OrthoDB" id="1696280at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004165">
        <property type="term" value="F:delta(3)-delta(2)-enoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF75">
        <property type="entry name" value="ENOYL-COA HYDRATASE_ISOMERASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0843">Virulence</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF13087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="289" mass="32548" checksum="FA7A8E7DDC7C8C86" modified="2013-05-01" version="1" fragment="single">MSSTTSKAGKVLFEIPLRDESDGVEEGDRAGANDNKIVCTEPAPRVYLLTFRNAPDNRLVTSFCKSLLLSLSILQHRHPQGVVITTSSLPKFYSNGMDISHSNFHADYLPTYLYGLFRRLLTFPMPTIALVNGHAFAGGFMLAMMHDYRVMNVERGWVCLNELELGLPLRGAMLGVFREKVRDAGVLRKVVLEAKRFSGQEALQDGLVDGLGGLEETLRLVEEWGLVGKVAGREKGKSSVYGKLKREMWRGTIALLDDWVDESTRLGRMEREVREEDRVSLRSVENWER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M3B3V1</accession>
    <name>M3B3V1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">NADH-cytochrome b5 reductase</fullName>
            <ecNumber evidence="16">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SEPMUDRAFT_148143</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">May mediate the reduction of outer membrane cytochrome b5.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 16">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15 16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="16"/>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762553.1">
        <property type="nucleotide sequence ID" value="XM_016904733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B3V1"/>
    <dbReference type="STRING" id="692275.M3B3V1"/>
    <dbReference type="GeneID" id="27901870"/>
    <dbReference type="eggNOG" id="KOG0534">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003827_9_1_1"/>
    <dbReference type="OMA" id="KGPEMQK"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000032">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000009">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF171">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15 16" id="KW-0274">FAD</keyword>
    <keyword evidence="4 15 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="10 16" id="KW-0520">NAD</keyword>
    <keyword evidence="9 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="17">
        <location>
            <begin position="88"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMF14432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="339" mass="37054" checksum="B37C71EA798B2A21" modified="2013-05-01" version="1">MFSTRLFRPAAQLSQHVRRYASEAPKSGGTNPFLLGAVGVAALGGGYYAFSGTKDPVATAIENTAAAYENKTPAQGGPPDKVFIGGDQGFISLKLDKVEDVNHNTKKFIFAFENPEAVSGLPVTSALITKYKGPEDKKPTIRPYTPVSDEGDRGHMDLLVKKYQGGPMSTHLHDMKPGDTLEIKGPIPKYPWSTNKHDHVALIAGGTGVTPMYQLARGIFNNPLDKTKVTLVFGNVTEEDILLKPEFDQLEKDFPQRFRAFYVLDNPPAGWKQGKGFINKELLKTVLPPSDSENVKVFVCGPPGLYKALSGPKKSPQDQGELDGILKELGYTKEQVFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-05-03" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>M3BPC5</accession>
    <name>M3BPC5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_152326</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF08018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756139.1">
        <property type="nucleotide sequence ID" value="XM_016907377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BPC5"/>
    <dbReference type="GeneID" id="27904514"/>
    <dbReference type="HOGENOM" id="CLU_2514074_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF08018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="85" mass="10075" checksum="4D82E8A3A1BA5B12" modified="2013-05-01" version="1">MDRYEGQLHSKSRQYVGTHELCFSSMVCRKCSMLLPCADRKKWKAPEKEVLAHQSAFLTFSRCGWRIHDDSEIRERQCEPDVHIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M3BRE0</accession>
    <name>M3BRE0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acyltransferase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_166385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756809.1">
        <property type="nucleotide sequence ID" value="XM_016908226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BRE0"/>
    <dbReference type="STRING" id="692275.M3BRE0"/>
    <dbReference type="GeneID" id="27905363"/>
    <dbReference type="eggNOG" id="ENOG502RYMZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005679_13_5_1"/>
    <dbReference type="OMA" id="KETNFQY"/>
    <dbReference type="OrthoDB" id="5819582at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050879">
        <property type="entry name" value="Acyltransferase_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028:SF134">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="454"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="2">
        <location>
            <begin position="79"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF08688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="519" mass="58906" checksum="30435BD1A6D46772" modified="2013-05-01" version="1">MADSHFELESGEWKDAPTLADEPNTLAAVSTVIRNIVLQAYVRATQSRALSTLIPKSVAKSWEQITPASAPRTTSRTASYDGLRGLACLVVFHFHFLYPYSDSMKHGFGSNAENRYILQLPIICLLLRGRAMVTLFFAISGYVLSYNFLASCREKQWDNAFSRLASLTLRRWLRLFLPATFTMMLVCIGVQLGFYSSARELQFNPLAAGKWEEHPPHFPDLRTQIKDFAGMWWVWSSPFRWDLNYTPYDPHTWTIPVELRCSLILFVFLVGSAGLKQRWRTGLTLLVATYCLFQNRWDVATFIGGALVADLHQAALYREGQKVPPHVDSSAVTTAPPKGSAITTTLKWLLLATSLYVLSFPDNLSKKTPGYRFLRSITPPSYREAHFFWHAFASSFVLWCVQAIPQIRMFLSSPIPQYLGKTSFALYLVHGPLLHSIGFNLQPKIWEVTGSDTMVPWCAGLFVGWLVMFPLSMMTAYVFYRFVDIPLVRLARYIESLARDDTAFRKPRAEDEKGPSAQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M3BSP9</accession>
    <name>M3BSP9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">T-complex protein 1 subunit zeta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">CCT-zeta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_136419</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF09118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757239.1">
        <property type="nucleotide sequence ID" value="XM_016902775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BSP9"/>
    <dbReference type="STRING" id="692275.M3BSP9"/>
    <dbReference type="GeneID" id="27899912"/>
    <dbReference type="eggNOG" id="KOG0359">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008891_3_1_1"/>
    <dbReference type="OMA" id="LHPRIMT"/>
    <dbReference type="OrthoDB" id="10052040at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03342">
        <property type="entry name" value="TCP1_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000058">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000004">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012722">
        <property type="entry name" value="Chap_CCT_zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02347">
        <property type="entry name" value="chap_CCT_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF09118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="542" mass="59110" checksum="9C807AF236174F0C" modified="2013-05-01" version="1">MSAAQLLNPKAESRRRGEALRVNISAGEGLQDVLASNLGPTGTLKMLVDGSGQIKLTKDGSVLLKEMQIQNPTAVMIARAATAQDEICGDGTTSVVLMVGELLKQADRYIAEGLHPRVITDGYDVAKNETLRFLDEFKLPKEVDRELLLNVARTSLSTKINKTLAEQLTPDIVDAVLAIYQAPAKPDLHMIEIMTMQHRTAADTQLIRGLALDHGARHPDMPKDVRNAYILTLNVSLEYEKSEINSGFYYNSAEQREKLVESERRFVDDKLRKIVDLKKEVCGTDPKKGFVIINQKGIDPLSLDVLVKNGIFALRRAKRRNMERLQLICGGTAQNSVDDLTPDVLGWAGHVYEHQLGEEKYTFIEEVKEAKSVTILIKGPNAHTITQIKDAVRDGLRSVYNMIVDGSVVPGGGAFQVAAARRLTSDEFGKQVKGKAKWGVAAFADALLVIPKTLAANSGHDIQDCIATLQDEHADGHVAGLDLTLGEPMDPEQQGVFDSFRVLRNSIASSTGIASNLLLCDEMLKARQMGKSGPPGGGGEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M3BT27</accession>
    <name>M3BT27_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_119561</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF09820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757941.1">
        <property type="nucleotide sequence ID" value="XM_016901522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BT27"/>
    <dbReference type="GeneID" id="27898659"/>
    <dbReference type="eggNOG" id="ENOG502RNF2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1556236_0_0_1"/>
    <dbReference type="OrthoDB" id="3828405at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004031551" description="Secreted protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF09820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="172" mass="19040" checksum="A44B89E9CB6ED1C1" modified="2013-05-01" version="1">MRFFAAFLAMLGVASAIESYKSVQCGRKNQYIVNTVNRFCAKTNMVAPSTYTRNGLLSLNTYVWLGINGNCNPAQWVPSAICKSQFFDMCISGNDLGANYRRYGRNNCQVWEVSATKSQHGGGSGVQHNNGLGKQGGWKDLKKAFGIHKRDDETHESMKEAENVEGTTNVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M3BUD2</accession>
    <name>M3BUD2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_151271</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758411.1">
        <property type="nucleotide sequence ID" value="XM_016906709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BUD2"/>
    <dbReference type="GeneID" id="27903846"/>
    <dbReference type="eggNOG" id="ENOG502T1TY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079673_1_0_1"/>
    <dbReference type="OrthoDB" id="4156595at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF10290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="206" mass="23144" checksum="C1912BF3F4431554" modified="2013-05-01" version="1">MSAPGNTTTTTTTTTTATTTTPTTPTGDPKQHVKSHSGRRQSRNKKQPDPFLDLPDDVLKQAAAGAASTPSPKSDNQPPHSLLVHLFFTPISVISFILSLFLIERQQRQWRYQQQLQVQQQQQQQNPTTAQSQSGRWLLSGPEPYQESPETTWHPRLSWRRRGIAKMQISDVLEMKGRVAVAIAVWMAVAVGVCAYGIRWLWGWMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M3BV32</accession>
    <name>M3BV32_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Wax synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_109285</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the wax synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759300.1">
        <property type="nucleotide sequence ID" value="XM_016900775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BV32"/>
    <dbReference type="STRING" id="692275.M3BV32"/>
    <dbReference type="GeneID" id="27897912"/>
    <dbReference type="eggNOG" id="ENOG502S25K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032160_0_0_1"/>
    <dbReference type="OMA" id="FLVWGVW"/>
    <dbReference type="OrthoDB" id="1077582at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044851">
        <property type="entry name" value="Wax_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032805">
        <property type="entry name" value="Wax_synthase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL O-FATTY-ACYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595:SF57">
        <property type="entry name" value="OS04G0481900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13813">
        <property type="entry name" value="MBOAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Wax synthase" evidence="9">
        <location>
            <begin position="554"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="150"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="264"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="484"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="17"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="271"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="300"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="322"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="484"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF11179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="710" mass="78738" checksum="2C8DC285EB877B27" modified="2013-05-01" version="1">MYVCYRLMGWNGNRNKNGNKNKNKNKNKNKNKNKNKNKNKNKNKNKNKNKNKNKNKNKNKNKNKNKNKTRTTTRTTRSGNKNEKRSTTMTSSLPPILPRFFHHAIQSFFTGEPRPGLQPIPGTKPLTFEALLCPVLLYYIALLLLPPSSSPSPSPSPSPQSPQKQQHHHQKSLPASSPTSTSFQISTLRNLLALSAAYFFLRLPCAYHVPQSIGLTYQLGLVGVYGGLRVLDAFFVSYYGFGHVPRRVRYSHLVRAETPRGEVMMRPWADGGSGRSGTDDGGGGGGDGDGGKGGEGMKGGAKQEQQQQQQQPTVIQDDDDSTAMTKTANSTSVEKNHQNPESSSLRPRPQPPPRIISQSDLLENMTSQSYTDLLNNDDGYMTLMKKLLDGPKPIPVTETAHTEDGWPHGFGDRAAWALELELSMRGVGFTWTTADVRHTTKTWLPTVQNRVHSILVHVGPVLVVAWAIIKTIYVKRLAVISSSSSSSSSSSSASSKQPPPPESPFDALTFPEQYLLTAALGAFLMAAFSLGHSLFAILCSPLAPSPLAFFPPLYTTRVWEITSARSFWSYGWHRLFARLFLVWGVWPGEWVERKLMGKRSDQAADVGKVLGGFLSSAVVHAFSVRSTLGGKWSDAAGEAKFFAYNGVAILVEELVKMGVKKWRRSRGRKEKMWYDAVVGRIWWIGLLLTTGRNFARGWAKAGLVREMAFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-05-03" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>M3BVC6</accession>
    <name>M3BVC6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_109376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759405.1">
        <property type="nucleotide sequence ID" value="XM_016900778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BVC6"/>
    <dbReference type="GeneID" id="27897915"/>
    <dbReference type="HOGENOM" id="CLU_1788017_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004031991" evidence="1">
        <location>
            <begin position="20"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF11284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="145" mass="15615" checksum="6C746760BD6462EA" modified="2013-05-01" version="1">MFASSLLAILLALTSTAHAACSDHEVRLDCKSGGCPKEEATCPEGIEGVVAQSRMVTRYSCDTTLPVCLVKLGHAQASVALETTTCEALLPPTPTVYTVLHLTQQQKLDRSRPCIMNAFRPLSTRVGASQHYSLPLVLAGQFEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M3BVR9</accession>
    <name>M3BVR9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CAIB/BAIF family enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_150359</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759540.1">
        <property type="nucleotide sequence ID" value="XM_016906117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BVR9"/>
    <dbReference type="STRING" id="692275.M3BVR9"/>
    <dbReference type="GeneID" id="27903254"/>
    <dbReference type="eggNOG" id="KOG3957">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033975_0_1_1"/>
    <dbReference type="OMA" id="IIAGPYC"/>
    <dbReference type="OrthoDB" id="5863171at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047369">
        <property type="term" value="F:succinate-hydroxymethylglutarate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1540.10:FF:000005">
        <property type="entry name" value="succinate--hydroxymethylglutarate CoA-transferase isoform X4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="entry name" value="formyl-coa transferase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050483">
        <property type="entry name" value="CoA-transferase_III_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48207">
        <property type="entry name" value="SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48207:SF3">
        <property type="entry name" value="SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF11419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="444" mass="48023" checksum="CCDCBE3270B2C0F7" modified="2013-05-01" version="1">MSFHKSLRLLSRSSSLQTTGRAPSQRRWLATPASDPSKLPLAGIRVLDMTRVLAGPYCTQILGDLGAEVIKIEHPTRGDDTRAWGPPYATYTEQSGKQGAGESAYFLAANRNKKSIGLSFQSPAGVEILHKLAKECDVLVENYLPDALKKYNMDYASVSAVNPSIIYASITGYGHTGPNKKRAGYDVMVEAEFGLMHITGHRDGPPAKVGVAVTDLTTGLYTSNSVMAALLARAKTGRGQHIDVALADCQIATLANIASSCLISGKPDSGRWGTAHPSIVPYKGFKTKDGDILIGGGNDRLFGILCEKIGHHAWATDARYKTNADRVKVRDELEAKIEAVTTTKTTDEWLAIFEGSGMPYAPINDVKKTLELEHTLERNMITEVEHPTCGPIKLVSPPVKFSDTQPSIREPPPTLGQHTTEVLTELLGMKSDEIKTLKSDGVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M3BWV3</accession>
    <name>M3BWV3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amine oxidase</fullName>
            <ecNumber evidence="6">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_133256</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a secondary aliphatic amine + O2 + H2O = a primary amine + an aldehyde + H2O2</text>
            <dbReference type="Rhea" id="RHEA:26414"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:58855"/>
            <dbReference type="ChEBI" id="CHEBI:65296"/>
            <dbReference type="EC" id="1.4.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="6"/>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760647.1">
        <property type="nucleotide sequence ID" value="XM_016902553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BWV3"/>
    <dbReference type="STRING" id="692275.M3BWV3"/>
    <dbReference type="GeneID" id="27899690"/>
    <dbReference type="eggNOG" id="KOG0029">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004498_0_3_1"/>
    <dbReference type="OMA" id="EWTRGAY"/>
    <dbReference type="OrthoDB" id="5046242at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097621">
        <property type="term" value="F:monoamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001613">
        <property type="entry name" value="Flavin_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050703">
        <property type="entry name" value="Flavin_MAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563:SF14">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00757">
        <property type="entry name" value="AMINEOXDASEF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="7">
        <location>
            <begin position="154"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="174"/>
            <end position="175"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="485"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="571"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601613-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF12526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="605" mass="66183" checksum="B9371353D97EB28F" modified="2013-05-01" version="1">MSPHMKTIDVGNSSQAYYAAATSSHAQEIIHIAGQPGTNGQGIVPADYESQIQLALLNLRKILLASGTQVSDILKLTFYIVNYDPARRLHTRHIQKFLDGHRPAMTLVPVPALAGEGWLFEIEAVVAKHKPMPIARAPSTKTSTVDVVVVGAGLAGLTAAAKLIESGLSCVVLEARERVGGRTWSKTIGPTNDGTVDLGAAWINDTNQSHMISLARKFNLELVEQNTTGNAVLQTSEGDLKSFAYGELPPFLDAIKDNIAFIRDQTEADCQRLDLAFPQNTELDSMTFAAYLRRNGASEDAMKTATVWTRAMLGHDPEDISALFFLSYCKSGGGLLQMRSDRKGGGQHLRLRHGTQQFAECLARELPQGVLQFSSAVSDIQQLGHENVVVRSSGSTTLYHTRKVISAIPLPVLKKITLDPPLPLAKQLLIDSFRYGFYQKVMVVFQTPFWLTKGSCGLIQSFRGPAGVIRDTSVPIDNKHVLTCFVAGTPGKQWSRHNESERQRQILEQIANVFDYPNARNELVEIVTLPWSDEEWTGYGCPSPALPPGVLDVAGHAIRDSFRDLHFVGTETSDVWKGYMEGAVRSGDRGAVEVIRSLTSVVAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M3BY02</accession>
    <name>M3BY02_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Histone H3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SEPMUDRAFT_126005</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the histone H3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761057.1">
        <property type="nucleotide sequence ID" value="XM_016902028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BY02"/>
    <dbReference type="STRING" id="692275.M3BY02"/>
    <dbReference type="GeneID" id="27899165"/>
    <dbReference type="eggNOG" id="KOG1745">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078295_4_0_1"/>
    <dbReference type="OMA" id="HIFAEMA"/>
    <dbReference type="OrthoDB" id="842664at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000010">
        <property type="entry name" value="Histone H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00322">
        <property type="entry name" value="HISTONE_H3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0488">Methylation</keyword>
    <keyword evidence="11 12" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="14">
        <location>
            <begin position="44"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMF12936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="136" mass="15406" checksum="D0DE73365501A3C2" modified="2013-05-01" version="1">MARTKQTARKSTGGKAPRKQLASKQARKSAPSTGGVKKPHRYKPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKSDLRFQSSAIGALQESVEAYLVSLFEDTNLCAIHAKRVTIQSKDIQLARRLRGERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M3C135</accession>
    <name>M3C135_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar-sorting protein SNF7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Vacuolar protein-sorting-associated protein 32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_147864</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762122.1">
        <property type="nucleotide sequence ID" value="XM_016904562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C135"/>
    <dbReference type="STRING" id="692275.M3C135"/>
    <dbReference type="GeneID" id="27901699"/>
    <dbReference type="eggNOG" id="KOG1656">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071097_1_0_1"/>
    <dbReference type="OMA" id="MKQIHGG"/>
    <dbReference type="OrthoDB" id="5592979at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904669">
        <property type="term" value="P:ATP export"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070676">
        <property type="term" value="P:intralumenal vesicle formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF10">
        <property type="entry name" value="GH13992P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="182"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="25"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF14001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="227" mass="25373" checksum="A6C75C574092F4BC" modified="2013-05-01" version="1">MASWGWGNLFGGSTAAKKDAPKNAILRLRSTLEMLSKREKHLQNQMDEQDAVARKNVTSNKAVAKAALRRKKAFEHQLEQTSAQMMTVEREISSIETANINKETLDAMKGAQQAMKKIHGDLSIEKVDQTMEDLREQHAIGEEIADALTQGNSMQGVDEDELEDELAELQQEELDNKMLRTGNVPMSDQLSRLPNQPVGEIKGKQNAAAVEDDEEEELRKLQAEMAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M3C1V9</accession>
    <name>M3C1V9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">STB6-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_82416</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762417.1">
        <property type="nucleotide sequence ID" value="XM_016910307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C1V9"/>
    <dbReference type="STRING" id="692275.M3C1V9"/>
    <dbReference type="GeneID" id="27907444"/>
    <dbReference type="eggNOG" id="ENOG502QT8Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010065_0_0_1"/>
    <dbReference type="OMA" id="AKFYQLY"/>
    <dbReference type="OrthoDB" id="19806at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070822">
        <property type="term" value="C:Sin3-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038919">
        <property type="entry name" value="STB2/STB2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059025">
        <property type="entry name" value="STB6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31011">
        <property type="entry name" value="PROTEIN STB2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31011:SF2">
        <property type="entry name" value="PROTEIN STB2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25995">
        <property type="entry name" value="STB6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STB6-like N-terminal" evidence="3">
        <location>
            <begin position="62"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="428"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="846"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="480"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="563"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="590"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="622"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="643"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF14296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="899" mass="99687" checksum="0D3B55FA17A43DD7" modified="2013-05-01" version="1">MTAKTVQERAKLRPPPLQTSSLSQPAPAGAALFPPHPPMPGQVERYPELDESATQEPKSGQQRFVLTDPVAFRYLEEDASTTLVDRRADLRGYECWIVEQWTTSRMHPTFMITTYTGDPSHTVKVGVLSVPTDESTWSSRLRVYFKALNQFHAKRRETPLGILMVTNLTGFPSSLAVIPVPDGDVGKHRFDFFVNEDLKRLGCSGRVGLSLSQPAASTVVKFHQLYRTSDKNDIYKSVIELVKLCQSALTLFDKLEIDYADGLLCDVTERAINDWWVEMGSDHYNVEPHDGILGPTTVSGLLGMLMGARNRLHAMSAPVSKDPFDIVTMKKAISAFQKQQRLPRTRRLDRRTMNRLHKATQKAADKVHWTMPRAVKSTVAELSGKGGDLHDGLGRRDRAGIAEIETVDIERFVQLVYGDRCKWLWLGKPPKKHKTSDAADRASQDVQEAPQFSKGLVFRSDEHGGFTWTAGRKGTVDGSEPQRRDMEHEQQGDSGAPALSDEGEESDKDGQHPVFKRASTIKNDAKSGLSKVKDAVGFRGHKSKPSIDDPAALSPIEQRGNKRPLLSRSRTSPVSSPSSLNLSSRDPSRQVSAKSAAEQSSRLNTALSGSASGLEDYPESLTEVSGPQVTSEQGLRGPKDAASSKTATNDTGHQQHTRDNSSATSGTAELPSIAGSVYNGVDLSEVLPEKVETETDVPQLLRRTTSYSQFVTTELQPHDEHAHPRQLSFSLAEDSVLSWDPLPEDEYDPFASLEAQLAEQEHIANDAKRLRSVITALQTETAPWTQAELQKLFTILNQADRDQEALDHMYLPHLQTVRELQGHSGGLLREEKERLEDGVKEIEAFAAKLEYEVDALKSKVEDVTAAVKDYETGVMRIEERVTELEREAEVSDGWKCIMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M3C4B3</accession>
    <name>M3C4B3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_147081</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763237.1">
        <property type="nucleotide sequence ID" value="XM_016904072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C4B3"/>
    <dbReference type="STRING" id="692275.M3C4B3"/>
    <dbReference type="GeneID" id="27901209"/>
    <dbReference type="eggNOG" id="KOG1404">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_4_0_1"/>
    <dbReference type="OMA" id="REGLNQH"/>
    <dbReference type="OrthoDB" id="5419315at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000004">
        <property type="entry name" value="Acetylornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005685">
        <property type="entry name" value="PRK07483.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43094">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43094:SF1">
        <property type="entry name" value="AMINOTRANSFERASE CLASS-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF15116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="522" mass="56485" checksum="D2FE6A67DB2FAF52" modified="2013-05-01" version="1">MSPSVLLLNDGNVLDKEMPSPDDIVPVKTRRSAVLHRTLHYDPHRVVGAQGHVLRLSNGQHIFDATGGAAVACIGHGDIRVQDALMEQMQEVSYCHSLFYATQAAEDLAKLLVDSTDGEMSRAFFVSSGSEAMEAALKMARQYHLEKPQPEPQRSHFISRHQSYHGTTLGALAAGGHVARRGIFEPMLATNSSRVSPCYAYRGLESPTDTETAYVNRLEAELEAEFLRVGPKNVAAFIAEPIVGAALGCVPPVAGYFPAIRRVCDKYGALLIFDEVMCGTGRVGPEPSDRFPKPLHAWQDPLIGVVPDLQTLGKGLGGGYMPVAAMLASAHVVEVLEHGSGAFSHGQTYQGHPLACRAALEVQRIIMKDDLVANVRKQGALLGRLLKEKLGNHAAVGNIRGRGLFWGIEFVKCRATKECVEPSMGVAMGIHELGMQKPYDMSLYPGTGGADGHRGDHIILAPAYNVTSDEVRHIAETVTAVVGKYFRLNPHIWLDGAVSVSSKMEDPAPPLAEVHATHKPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M3C755</accession>
    <name>M3C755_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_61626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF16086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764207.1">
        <property type="nucleotide sequence ID" value="XM_016909570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C755"/>
    <dbReference type="STRING" id="692275.M3C755"/>
    <dbReference type="GeneID" id="27906707"/>
    <dbReference type="eggNOG" id="ENOG502SNM9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129980_0_0_1"/>
    <dbReference type="OMA" id="GNKHWNH"/>
    <dbReference type="OrthoDB" id="5176208at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39401">
        <property type="entry name" value="SNOAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39401:SF1">
        <property type="entry name" value="SNOAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032332" description="SnoaL-like domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF16086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="177" mass="19167" checksum="817BEB5C423FBAEF" modified="2013-05-01" version="1">MKFTSVLASACLFGIALSVDDSLYAPGPGVEPEFKAYLNELYYQAEQPPSTTEFTDFFTPDGKLIVRGIVATGAAEILALKQRLLPTAGNKHWNHIQNATTVDSESSTQKTYQVLGIIDTTYDGGNCSRAYYSSRFTVIKGAGGALDLSPRVKNLAAYDDFIIQPSVSPTDIPCEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M3C7C9</accession>
    <name>M3C7C9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Heat shock factor binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_124250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HSBP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF16171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764292.1">
        <property type="nucleotide sequence ID" value="XM_016901902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C7C9"/>
    <dbReference type="STRING" id="692275.M3C7C9"/>
    <dbReference type="GeneID" id="27899039"/>
    <dbReference type="eggNOG" id="ENOG502T7EM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2440827_0_0_1"/>
    <dbReference type="OMA" id="TTKFNTV"/>
    <dbReference type="OrthoDB" id="4159489at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009643">
        <property type="entry name" value="HS1-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06825">
        <property type="entry name" value="HSBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF16171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="103" mass="10975" checksum="D157DA574236E1FC" modified="2013-05-01" version="1">MSADSTASLSAQVNKLNINNDATSDPPTSTRPTTSSSPTTRTTETKPSELVAVVDDLLVQLNSKFSQVSTEMLGKLDDMSKRLDALESQIRAGNAGGKEEDEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M3C8A2</accession>
    <name>M3C8A2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_121622</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF08125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756246.1">
        <property type="nucleotide sequence ID" value="XM_016901700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C8A2"/>
    <dbReference type="STRING" id="692275.M3C8A2"/>
    <dbReference type="GeneID" id="27898837"/>
    <dbReference type="HOGENOM" id="CLU_1020027_0_0_1"/>
    <dbReference type="OrthoDB" id="3649705at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="156"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="82"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="242"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="119"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="261"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF08125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="273" mass="29548" checksum="CA490C3F5F4DAC9D" modified="2013-05-01" version="1">MAAPTLPPLSPSPPSRTTRSRRVSTKAANAASDLRATTNKIAKATRQQRRAAVNPSMTTTTAAELTVQEKILRYVGYRAPAQTTASEGEEQERHGEGEEEEGLGDALPEPTEKPMAKTSSPSSSSISSSHPSLSIPSCTINTTINNTTTTTTTTTDTICLCALTVTLEETPVEDLIKCSIRDCDQWFHLACVGLPEHPPWYLGWNCADCLAHQRIPGNVKGLYDVKAKDSSVRAKAWLKEVKEEAKGEGIKKKEREGGMKRGVKGGVKSKKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M3C9E5</accession>
    <name>M3C9E5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_152096</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756551.1">
        <property type="nucleotide sequence ID" value="XM_016907240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C9E5"/>
    <dbReference type="STRING" id="692275.M3C9E5"/>
    <dbReference type="GeneID" id="27904377"/>
    <dbReference type="eggNOG" id="KOG4750">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_373849_0_0_1"/>
    <dbReference type="OMA" id="WHGDIAN"/>
    <dbReference type="OrthoDB" id="25818at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051159">
        <property type="entry name" value="Hexapeptide_acetyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024688">
        <property type="entry name" value="Mac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416">
        <property type="entry name" value="SIALIC ACID SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416:SF76">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12464">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="314"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="15"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="413"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="507"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="192"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="235"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="250"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="263"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="455"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF08430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="782" mass="85743" checksum="2B1F9531A6265DAF" modified="2013-05-01" version="1">MTCIRLPRPDQLEVDWRQDSPMRDDVGILNRTPSSDHRSNGLPTRDAPPTSFTAVNGDAHRSGSHRPEAAAARPIILPPPVEQITNHNNNNHSHNHNNNNHNHNHNNNDNVTSERATTSLTGPYQAHSWRPTEQQGTAPHEAAAAAATAAAASSSTDTHKAASNKRKRAPSSSAEELREDSRRQQPNAGADSLERRAHDDDHRDDVRESRGFRDGHGELEESTTGPYVRVDSPARGPPGPAPPAPRPETEAALAAQVAQVQQFSGHAQTRPGSSGSPEEAQARQRSHPHGSEQGQSVDDRSKRKRNFSNRTKTGCHTCRKRKKKCDEGKPYCQNCARGSFECEGYGPKPVGGSKTGPTRSVVPLQSKTNEGYAPIHDQHYGFEPAPYHDPPPRPLPPGGERYALSLPRVHDIHTPRYTGPTPAGGLRPTSAREGYAPWHDLREGPSTAPRTSPDVPRPPPHAHRYPPPPPPIQYPYLPPSEPWHAPPPPIYPPLAPVARTILSSHESVFSGGSGSHRSYPMSHSNPEVPDSERAKMLRGEPYLHFHDPDLKEERLSCLRAVETYNDSRKGSSIAPGNVQSRNFQDVYDPAARAWGNGLWNGPKGTVGSHTVVEAPVTCEFGYNIHLGNDVHIQQNCTLQDASIIYIGDRTIIGPNVKFYCITTSMDINIRQQKSDRDPLKRGPRFEAGPIRVEDDVVIHADCIILPFRTIGKGAVVGAGSVVTRDVKPYTVVAGNPAKPVKGRRKLAGGPEVDRHCEDIQEQNDAMLARLRNNEVIPRDDLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M3C9P7</accession>
    <name>M3C9P7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SUZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_152188</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756681.1">
        <property type="nucleotide sequence ID" value="XM_016907290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C9P7"/>
    <dbReference type="STRING" id="692275.M3C9P7"/>
    <dbReference type="GeneID" id="27904427"/>
    <dbReference type="eggNOG" id="KOG2953">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018298_0_0_1"/>
    <dbReference type="OMA" id="PFCRVPP"/>
    <dbReference type="OrthoDB" id="278430at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02642">
        <property type="entry name" value="R3H_encore_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051937">
        <property type="entry name" value="R3H_domain_containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024771">
        <property type="entry name" value="SUZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15672">
        <property type="entry name" value="CAMP-REGULATED PHOSPHOPROTEIN 21 RELATED R3H DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15672:SF8">
        <property type="entry name" value="PROTEIN ENCORE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12752">
        <property type="entry name" value="SUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51673">
        <property type="entry name" value="SUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H" evidence="3">
        <location>
            <begin position="264"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="SUZ" evidence="4">
        <location>
            <begin position="328"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="21"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="354"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="543"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="781"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="543"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="562"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="649"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="788"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="798"/>
            <end position="807"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF08560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="838" mass="89738" checksum="6E980A0A49A270D9" modified="2013-05-01" version="1">MTSSAAPNAADIKKEKLSFAKIAAAGIKPPNPQQNSHNNPSAKQKHDITSAPRDGITVSPPSGVALPQSMLKPKKLVQLASREAKDSPCDPAHRPQVRVQLADQQPLRPTGQTSEGSCTPAHADDASSSDSNKPLSMDGKSVASGTTFNALDEKESLRPDDSASVKAVEDEDLYSAPGSGMPSRGGSDDGARAFRDQLLEISAIRGGPPPSYGIAPKGVLYVPPHGPGVGAVPAATHGRGITNPTLECRPDQKLLDALDHPQDRVWVLKLEQDVLDFVKDAKESSLTLPQCHSFYRLLAHKMADYYMLGHIIDDSNAAVRLYKTPNCRIPPPLTGITAPSTAASTPPPMVPAMKILRRGDPDAPVITSGPGMRTKNGSDGESGDDKKKGPKTREEREARYEAARLRIMGSAKPLESPETPKEKQDSRSSSAAGKKHKKKARADDDDGFEARSAYSNFFTAYGSDGVPAPAYSYPQVNEQAANQFQAIYGQQSQTGPFTQPIASVAGNMQWNQQPYQNVDPTQAWAQGQTGPYDLSADFQRMSVQSQMPPQQSHNMTHGQGYGSNYGQQYFSPQQNWQQQQQQPPQTQQYPGPAQSPSSGYGYGANFPPPTNSSPEQGYQFGQLPSQAFPGRPANMNEHPLPGSYKGKNFNPQSQTFVPGQPNGSPVTPQGIPSTPGGFRQPFQAHSPVQLARHASAQSQASSFGSPHQPQQHLAPPRAMGQPLVHPLPQGPVFPRQTSPSVPLPAKPGSGQQYQIQMPMQAPAAHAVQAQSLLAKWGTPSSLPAKPPPTREHFDSQKMSHIQRQPFNSAAAAPRQPGGFSPYSMSPGHLVNGGGVYKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M3CAV9</accession>
    <name>M3CAV9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dienelactone hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_159035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757071.1">
        <property type="nucleotide sequence ID" value="XM_016907819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CAV9"/>
    <dbReference type="STRING" id="692275.M3CAV9"/>
    <dbReference type="GeneID" id="27904956"/>
    <dbReference type="eggNOG" id="ENOG502RYJ9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032662_2_0_1"/>
    <dbReference type="OMA" id="GTDHKRH"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030638">
        <property type="term" value="P:polyketide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009959">
        <property type="entry name" value="Cyclase_SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436:SF3">
        <property type="entry name" value="CARBOXYMETHYLENEBUTENOLIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436">
        <property type="entry name" value="POLYKETIDE CYCLASE SNOAL-LIKE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF08950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="404" mass="44709" checksum="E44419C1ADEE9BFB" modified="2013-05-01" version="1">MSAFNTPWFNSQDPSFFNSLNKSKIAHVALCAETEDFDEEVMQAWKDEGFHCVYVPLLEGGDDFIRRLHIVGDQFGVSEQYAVVAYGTAANLALLGHTKPNHPKLVAIVAYYPNVIPSIHTKYPAGVKVLVHLAGNEVTVQQHHEVLGLQGKRSLVKKRIDPGIGYGERLNIAFQTYTYTGCRSGFAESDLEEFDPVAAKLAFTRSLTTVRKGFRVEPDVEAVRDHHVSYLHSGKIEAMVKQTRETAHIIHTPTLTGGVGAEDIGEFYNEFFTPLQPGGDGPGATILKLLSRTIGADRIVDEIYLSFGHTREISWLLPGTPPTNRKIEIVMVSIFHVVGTKLESEHIYWDQASVLVQAGLLDPKLVPGEMKKKGMKMLPIVGAEAARTVKRGSSRHVNDLVPDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M3CBU3</accession>
    <name>M3CBU3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_70787</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF09887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758008.1">
        <property type="nucleotide sequence ID" value="XM_016909914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CBU3"/>
    <dbReference type="STRING" id="692275.M3CBU3"/>
    <dbReference type="GeneID" id="27907051"/>
    <dbReference type="eggNOG" id="ENOG502SN4C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030357_0_0_1"/>
    <dbReference type="OMA" id="TGIDTCL"/>
    <dbReference type="OrthoDB" id="10264306at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF09887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="476" mass="53633" checksum="52B6871244E0FB3A" modified="2013-05-01" version="1">MASTSPPTPIDVDYLVIGAGAMGLAFLDAVLTANPIATFALVDKYARPGGHWTTSYPFVHLHQPSAFYGVNSKILGQNKIDQVGFNKGLYELASSDEVCAYFHQVVQEVLLPSGRVQYFPKCEWIEGKREFRSNLTGERFEVGRQTRIVDATYMKVTVPSMRPPPFQVAADVKVMTPNELVTLSRPYSHYTVVGSGKTGIDTCLWLLSMGIRPQQITWVMPRDAWLYDRAHWQDLYDDRAKEAMKRQVECTLSATSLEDYLLRLEAAGMMLRLDQKVWPTSFRCATVTLAELDEIRKIKNVVRLGRVISIDAQEIVFQHGVQPTVPDTVYIDCSANGLEKRPAVPIFTPEKITLQPVRFCQQVFSAAFIGHVEAAYADEATRNELCRPIFHPTLPSDIPIVTLSDFRATLRWSVEPKTVAWLVNSRLNWSSAFAPLATDDPVELEQERLQLQALLHSMSEKLQQFIREGARVMAHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M3CDP0</accession>
    <name>M3CDP0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_118445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759262.1">
        <property type="nucleotide sequence ID" value="XM_016901430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CDP0"/>
    <dbReference type="GeneID" id="27898567"/>
    <dbReference type="HOGENOM" id="CLU_3033896_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF11141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="55" mass="6315" checksum="DC7F8D105C4ABBCC" modified="2013-05-01" version="1">MSERKVQDTLPSSEREDEAPEQPQTEERWKSGVAKVPLNLSEIVCKDSFHVVNPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M3CE88</accession>
    <name>M3CE88_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_150315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759482.1">
        <property type="nucleotide sequence ID" value="XM_016906085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CE88"/>
    <dbReference type="GeneID" id="27903222"/>
    <dbReference type="eggNOG" id="ENOG502T6GN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_347873_0_0_1"/>
    <dbReference type="OMA" id="VMEDCAT"/>
    <dbReference type="OrthoDB" id="3643655at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="609"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="323"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF11361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="811" mass="90179" checksum="118872EF5EFAD96A" modified="2013-05-01" version="1">MFLLFDAHPANMKNGRNQTDVLSIERTLGLKSERGISRQGNKDSPPIEAILKGIKLIMVAYVNQDLTIIRDSDALKAEATTLFDQYGPQIWPGPDEPRPHWLEEPSEMRHEGKYPKACHYTIPEDYEYLKERFIQLVIEKACNYHENQLQKHRRHTAKVLQSHSNGDNEGEDSRGEEADRDDSDSPGQPASKIDEFQSQFAAYTQPVPDEDGKPHGLPLTGGDNSQPSSARKRPRNNVNVEENSTFKRARSESIAGSSQGESLVVPSTYSFQPINGELTQEPPELPRAHGFNPVNAAPPPIAAAASAPNGMAHSMDSLPFSKPSPAASSQQPSSSAPNSNRMLPSVPVPPHQRPLPSLTGFPGSHESAADGPRNENQRDDRRQSDPRNYESPYGQHHPAFQGQKPEQFRSGFQPVNASSPGGTRPPVLQLPSHAHTLPAHTLQNPFRTFPSGPANSPPAFGAPRLEGQPLPTTFNTVRPSHVPLPEPVLSALGLQGPRPQSRSKQAPRRPSPSGHRRPSMAPSLPPMELAADRREAMPHSHVATPDPLDHDAVYFEDVLGDLATCPVIFKLKEELGPKMPRHRLDKLKKLLVDYPDARFELEALERRARMPSEQNEAERLPPPGWIQNPVGVWVPGAHAQQQQPQPQPPHMYSQPHSFGRDAALTPRPTPGPPAHQKSDAPSTPQVKDEHHDLPSGRSLDNILVEINWNRNLDYSDHVEMQEFDTVQKLFDMVEEARPDELLRDRDVIKEIRIKSKTELHGPGGQVLPRIVHDETRGRASVKQLIRKLRSQPPDMEIELVFDVMWKPGEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M3CFX2</accession>
    <name>M3CFX2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Oxidase ustYa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_163783</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760829.1">
        <property type="nucleotide sequence ID" value="XM_016908080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CFX2"/>
    <dbReference type="STRING" id="692275.M3CFX2"/>
    <dbReference type="GeneID" id="27905217"/>
    <dbReference type="eggNOG" id="ENOG502S0J4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042941_4_1_1"/>
    <dbReference type="OMA" id="GVEHDCI"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF11">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF12708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="28273" checksum="28DB4DA95C5063CA" modified="2013-05-01" version="1">MVDFAHKYEEVPTLEGGSPPVRSSRSRSSIWHYLCISILAIGWVGTIVYNHRAPPKENGPLHLYTNTPIPKEVFKPVKVIFDKDPKYMGYSKEVNDEWDLLVAGHDALWVEDPDKYGLGEGIVAPFDHPNTPIPKPRNFYVVSLLHQLHCLNMIRYQYYVEKFQVENDEPVKWKVHVEHCFEYLRQAISCGGDLVIEGESQIRVGHGHATSVTGWGVEHDCIDFDKLLDFQRLQEARYNQTWQNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M3CHT7</accession>
    <name>M3CHT7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_148682</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM170 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761469.1">
        <property type="nucleotide sequence ID" value="XM_016905078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CHT7"/>
    <dbReference type="STRING" id="692275.M3CHT7"/>
    <dbReference type="GeneID" id="27902215"/>
    <dbReference type="eggNOG" id="ENOG502S0YM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071343_1_0_1"/>
    <dbReference type="OMA" id="FPMQGGL"/>
    <dbReference type="OrthoDB" id="2131401at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019334">
        <property type="entry name" value="TMEM170A/B/YPR153W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22779">
        <property type="entry name" value="SD17342P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22779:SF6">
        <property type="entry name" value="SD17342P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10190">
        <property type="entry name" value="Tmemb_170"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF13348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="143" mass="15924" checksum="847725FDEAD92FE1" modified="2013-05-01" version="1">MTNRFLRLQVNPKPLSYEAPPFPSLYWPFPVSGPQNVYLYDAESMWRFTLYWTLIVVGGVHMIAAAYACAIQWRNWKMIWMVPVMYGVVGGIEAVIAGCVTGGLLGGVYTSGFFRMSTWVPFGWGITNALVLILASFAIQGGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M3CI17</accession>
    <name>M3CI17_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_125204</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761534.1">
        <property type="nucleotide sequence ID" value="XM_016901961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CI17"/>
    <dbReference type="STRING" id="692275.M3CI17"/>
    <dbReference type="GeneID" id="27899098"/>
    <dbReference type="eggNOG" id="KOG0296">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_9_1"/>
    <dbReference type="OMA" id="SIWDYSK"/>
    <dbReference type="OrthoDB" id="10261640at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051179">
        <property type="entry name" value="WD_repeat_multifunction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857:SF8">
        <property type="entry name" value="ANGIO-ASSOCIATED MIGRATORY CELL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857">
        <property type="entry name" value="MITOCHONDRIAL DIVISION PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="67"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="12"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF13413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="510" mass="53427" checksum="AD686A9133486575" modified="2013-05-01" version="1">MASNQNGHREVEEEEEDQAMLDPNEAEEVVEDEDGDAAMDSGGEEEDDGPGDVQQTIQLQNDSVAHFDAHKDSIYCIAQHPTRPEIIATGGGDDTAYVWDATPEPGPVLPASYETNPQPRERQSQQVIAKLGPQDETVNTIAFTLPRGDFIATGTAGGTLNVYTTPTAQSPQPHLVASAKEVDDITWIVPCPSTNEAYANTIALGAADGSVWIYSIDGQNLNMIQSFFLHQAPCTAGAWTPGGQLLATVDEASSLYVWDVFGEAAAAGVSDPNGSQAIIRFTADDERFKVDGGLYSAAISPGGGIVAVGGAFGNIRVISLPRLSPSAPSSSSQQKSAGKSKAPAAGASSYGQILSAFAAQTDGVETLDFSQPPLTLLAAGSVDGSIAIFDAAKSFAVRRLIKDSHALDEVPHAVIKVEFAKTPLGTANTKAHLLTSCGNDGVVRRWDVRGGTASAGQGLVKEWKGHMENDGERGGILGFVQGNGHKQVAGSHVITAGDDHVSLVFEHRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M3CIF5</accession>
    <name>M3CIF5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1295-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_132868</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761724.1">
        <property type="nucleotide sequence ID" value="XM_016902518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CIF5"/>
    <dbReference type="GeneID" id="27899655"/>
    <dbReference type="eggNOG" id="KOG4650">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043418_1_1_1"/>
    <dbReference type="OMA" id="FQMLWVW"/>
    <dbReference type="OrthoDB" id="67965at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="UstE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE (DUF1295)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="63"/>
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    <feature type="transmembrane region" description="Helical" evidence="2">
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            <begin position="109"/>
            <end position="129"/>
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    <feature type="transmembrane region" description="Helical" evidence="2">
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            <begin position="197"/>
            <end position="217"/>
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            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF13603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="348" mass="39039" checksum="491A6CA8D7AE7557" modified="2013-05-01" version="1">MPTHAAVHVLDNYYLAITLLVTVAYQLIGFAFAFSFKFDKLTDFMGGSNFVLLGILTLALSGTTNARQIITSLMLMLWATRLSGFLLFRILKTGKDDRFDDKRDKFFSFLGFWVFQMIWVWTVSMPVTILNSPNVRQYPQPSFGKATDIFAIIWFVLHFGLEAVSDVQKYRFKQGPGKEPGAVCDTGFWKYSRHPNYFAEIMVQVSIYIIAVTPASYGTIPSGSGAYAALYASCVGFILLTVLLMFVSGLTLQERPGAKKRYEKGTGWHAYEKYLHDTSIMFPMPPAIWRKLPVFVKRTVGLEFPIYVFDPAKHADKDAVRESQAEEGRSESNGGGGGGNRQSTEPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M3CK19</accession>
    <name>M3CK19_SPHMS</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_154960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016907594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CK19"/>
    <dbReference type="GeneID" id="27904731"/>
    <dbReference type="eggNOG" id="ENOG502R2JA">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1111934_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF14148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="250" mass="27223" checksum="DB6CC1682A67546F" modified="2013-05-01" version="1">MTLRSSMAATGKRKANDANSNGLYQNDRLILKRRDTSISGFQNLNLYGHQHKQQEQHEATTDSAISIHNDTKTKFPSQQHYTSHLPSPPNSATTSQDEFMNDNNHTCNNDHHINNPPHHLLLTFQSHLTTFCQTHGSIFGPGYLHTLQTSHLTATTSLEPATILSAGQTFTHALNRYVAELQSAAIRQVQLRGDLVRVGGIDSVALEALDAVLARLDERIVVVGAEAQGLEFELGLVEGEVEGGGGGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M3CKX4</accession>
    <name>M3CKX4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">FabD/lysophospholipase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_148129</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762534.1">
        <property type="nucleotide sequence ID" value="XM_016904723.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.M3CKX4"/>
    <dbReference type="GeneID" id="27901860"/>
    <dbReference type="eggNOG" id="KOG4231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003059_2_1_1"/>
    <dbReference type="OMA" id="DGLPHEK"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047499">
        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046486">
        <property type="term" value="P:glycerolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07199">
        <property type="entry name" value="Pat17_PNPLA8_PNPLA9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16449">
        <property type="entry name" value="RING-HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185:SF1">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="673"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="11">
        <location>
            <begin position="739"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="985"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1214"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1437"/>
            <end position="1478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1514"/>
            <end position="1536"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="8">
        <location>
            <begin position="743"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="8">
        <location>
            <begin position="933"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="991"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1256"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1442"/>
            <end position="1464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF14413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1575" mass="174633" checksum="6989DA93D21BAB41" modified="2013-05-01" version="1">MTRNARLSTYTTADDVSSVSSSSDNDDEHDEPSEECEDDRCRGPQLPIWHCVDCDSSYCSDCWGLQGPHKPKKKGRDGVPHEKTSPFVVKRLQGILNPTRNPDMIQRLHEDDESTKWFGVSRDATGRPNFEDYGRYATLMSSISPVNLQNAGNRYPQIVSFIGVTNAGKSTLIKMLINHDAHNANAENRAMFPSPVVGSVVNDSLPTSGDVHLYADPSSHTEQLPILYADCEGFEGGERTPLGARSRRHAGAEPEAARPGHVHTRQIGWALNEESRQREYAVTALYPRLLYTFSDCVVFVLRNPKTFQSAVLTKLLDWGASSLEKSINQPALPHCIVAINGTDPSVDDKEWDVNYATQSLLSSVKTALDSVEGVPRFRELAAYWRNLGKHIYSVEDLVLRYYSSFKVIRIPAKPRYTTINEQVGKLQGIIKANCEESFRNKRRARMLTNADELNTYLQSGFDHFTSYLDIPFNFMQISLLRNPIPNDFGGHILQLCTTISAQQPNHQHGRIAWVFEKVSMMLASCVLLDCARFRKGRVDELFTNYEKFFDWAMGEYLEMHYPCSYVSADGTRQCMLVKARHSVKGHQDEKGIIAAGDYQAALDTDFLPQWKQQLRAAIGSIARDFQYELDQISHGDEPSVPEERIALDLHIEYINQFFEAVGPASSMVSHATCFCCLMDVPEHPLPCGHVLCTACIKAYGKPHKSTLQVSCCPLHRESTNWAKPANIRFKPVGAGARILSLDGGGIRGVVQLEVLRFIELALGRHLPVQCFFDLIVGTGTGGLIATALSLKDRSVDSITDMFTAMCDHAFTPRLKGVPVISQIAQLFGSAPKYKTKPLLGALKTAFTEDDDLFGSHDKPRNGARVALTATSATGQETILMASYRRPEDPMPAYAFERPHDPDMELKTHEAITASLASPSFFKPFVFHGKSYLDGGLRSPNPAFIADRERKLIWPDVAEPDIFLSLGTGQNRITVLQKLQDRQKDATLGSVAPTSSHASNSLKPGGRWRTKRTDDVLDAELAWQHFRHYVVRDRAENKTRRFVRFNPDLDREPPMADSKSDLLSLQVNVRKRLQTAHRQAALRNVAHRLVASSFYLELQSKATAEKSEQICTGIISCRFDDGSPELSGLGRILEECRTDDFEPYFLVRPDVERPDFTFKIAISPPLTQMMINSATLGLPNVYIPLRNENNPTAITLFLSKHDGLEPDGFAISGFPRVLLGEPKNPKTKRPVRKSSEAHLVRPSSRATQLARADGDSLSLNGANMSSGRSEQSDESWQDVQSKNGRPASAEKKQSLSDLIAQHQTGGGSSIRGRTNRFWSYIGNTHMAQNPDLYSPDELAKHGVDVSAFPRPPSAAANDLPNTGFPPNPSPEPIVDAPSIESVTALPSLRSRFAVPPMSGIPELDDRKTKAEFHGYHPGPHPLLALTQPTRSQVDIIHQLPTREASAASNSTSHSSSTAQNSSEASGKQDIPSMFETGFEEEDDDWISTYSGEEVMLAEAHASPLVQFPHVFPTRASSKRNPAEESPLEAAISGALPDENTASALDRWLAAQKRSSVRNNNERLKVVQEEAEGVDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M3CVM3</accession>
    <name>M3CVM3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_121681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF08192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756313.1">
        <property type="nucleotide sequence ID" value="XM_016901705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CVM3"/>
    <dbReference type="GeneID" id="27898842"/>
    <dbReference type="HOGENOM" id="CLU_2759427_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032865" evidence="1">
        <location>
            <begin position="21"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF08192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="70" mass="7399" checksum="8377DD8814A1252E" modified="2013-05-01" version="1">MPSSIMLKLLLSSLIAAVSARQICGTCYNAGNKPIFAGSATGGEWKCDAYCDQNMVNAANEVCCEGIYTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M3CW73</accession>
    <name>M3CW73_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_75084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456278">
        <property type="protein sequence ID" value="EMF07911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CW73"/>
    <dbReference type="eggNOG" id="ENOG502RA1T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3034148_0_0_1"/>
    <dbReference type="OMA" id="PETRCIT"/>
    <dbReference type="OrthoDB" id="3470073at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF07911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="56" mass="6294" checksum="9BE2F2EB97050954" modified="2013-05-01" version="1">MLDSLVRVSRRAADNHYAIILAEARTSPQPRCITRGYNTPPRGSYIPRVLSSGPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M3CWN7</accession>
    <name>M3CWN7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7918 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_121322</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756668.1">
        <property type="nucleotide sequence ID" value="XM_016901680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CWN7"/>
    <dbReference type="STRING" id="692275.M3CWN7"/>
    <dbReference type="GeneID" id="27898817"/>
    <dbReference type="eggNOG" id="ENOG502SAV6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_921866_0_0_1"/>
    <dbReference type="OrthoDB" id="3364132at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057678">
        <property type="entry name" value="DUF7918"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223">
        <property type="entry name" value="BETA-LACTAMASE-TYPE TRANSPEPTIDASE FOLD DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223:SF1">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR EAF N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25534">
        <property type="entry name" value="DUF7918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7918" evidence="2">
        <location>
            <begin position="9"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF08547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="302" mass="33738" checksum="B2E4E1FC177736D5" modified="2013-05-01" version="1">MAVTAVLPGVTISVVAEDRVLQEYPDVEVKDNKKTTTRYIEAVSGQTFSLEFEVTKETPMLGTYLAFHVFVDGTEVDELGLDTGYIRLYGDKGISQGRYLHGGLLQRYCFTDLNIVDHNDHVSQDLMSKLKELGTIRIEVHHKNRSSVHLPSAGFDTLLPATGAVSEKALKGQSVMQARSVEHMMSHSGAPSLLIPPGHQQQRSSSATGREVELKEEIKVKREQKSASPPRRYEEFEVGTAEMKLKIKFKREEKVNSPPRRKARRGTHVTVIELDDDGEIVSETTRPRNAPIDMSKSVPLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M3CWP4</accession>
    <name>M3CWP4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Palmitoyltransferase</fullName>
            <ecNumber evidence="11">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SEPMUDRAFT_152377</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="11"/>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF08091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756212.1">
        <property type="nucleotide sequence ID" value="XM_016907410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CWP4"/>
    <dbReference type="STRING" id="692275.M3CWP4"/>
    <dbReference type="GeneID" id="27904547"/>
    <dbReference type="eggNOG" id="KOG1311">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021757_0_0_1"/>
    <dbReference type="OMA" id="VPVKYCK"/>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF43">
        <property type="entry name" value="PALMITOYLTRANSFERASE APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="351"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="518"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="564"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="13">
        <location>
            <begin position="473"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="148"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="223"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="654"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="277"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="662"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="712"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMF08091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="739" mass="80597" checksum="4C9FA317F6E75CF4" modified="2013-05-01" version="1">MANMAHLASPNVNDNDNSSALPTFLARDPFPSGTDERPGTASSNGTSEFDGNKRLSVLSTTGPVGEPGLPPARPTSDATSGQSWPRTSSRASATVGGASALQRGSYSYRPFSRREGDISRPGSGMSGPTHVPSLSVQGFFRPLSSQRLQAQRGQHVAPPSSIQGGHRINRSVDEEEDEIPGHRKRYSDASVNTARDIAASRGGEAAPPLPAGRGFSAAMTSSGAPFIAGGPDSMVRRNSTTPLHSRQHTSEKLQTVDSKPKSPRSLRDSLGWASNRSRREINEHRRSTRDHEKLSSNPASPNLNAKERDASPAKLFPKSTGSRIGRNYQYYAGNYLFFCLGRCLNTRAKPLNLVTFVLTVLPAALFFGFSAPWLWHNVSPALPIIFAYIFFITFSAFAHAALSDPAVLPRNLHPHPPNADEERDPLTVGPPTTEWVMVKTFPSKKMKADLETQAAEEGAAGPNSATTAMEVPTKYCKTCKIWRPPRAHHCRVCDACIETQDHHCVWLNNCVGRRNYRYFFAFIGFGSIMALLLIAFSITHIATYANQHGISFGSALSGRTQEQVAFAMFIYAVLALPYPGSLFGYHLFLIARGETTREYLNSHKFLPKDRHRPFSQASMLKNWIAVLGRPRPPSYMSFKKAYQHGDIRLGHTLPKAQRQQKARVEAERSQSRVEGLKKRLSVPRGRVGQPQQANGGAQRAVEMKELPPPPTADSGIGSSAAGNGSMKKNVPGGANNTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>M3CXP7</accession>
    <name>M3CXP7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_111779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756552.1">
        <property type="nucleotide sequence ID" value="XM_016900937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CXP7"/>
    <dbReference type="GeneID" id="27898074"/>
    <dbReference type="HOGENOM" id="CLU_1548578_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF08431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="173" mass="18361" checksum="D377A3400DEF8F03" modified="2013-05-01" version="1">MSTVTRVPDRAPCAAHTQSHNSKSRADATGILAAQASTGTGGRMNGNAHVAARAICITLLGVKPANDSARARASSIPASARYGEKIAQYLPRITPLLLNPGFISNISIAIIDGVIITRPQSIIHYGMARMRCHSGMRKEVVTLLRPSVPERTVRLASMLPVDATPGQAEQTEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M3CXV1</accession>
    <name>M3CXV1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription initiation factor TFIID subunit 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_152144</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TAF13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756617.1">
        <property type="nucleotide sequence ID" value="XM_016907267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CXV1"/>
    <dbReference type="STRING" id="692275.M3CXV1"/>
    <dbReference type="GeneID" id="27904404"/>
    <dbReference type="eggNOG" id="KOG3901">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076665_1_1_1"/>
    <dbReference type="OMA" id="QLMKDAD"/>
    <dbReference type="OrthoDB" id="10266074at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003195">
        <property type="entry name" value="TFIID_TAF13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380:SF5">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID/SUPT3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02269">
        <property type="entry name" value="TFIID-18kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="126"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF08496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="162" mass="17925" checksum="CFF1DAA5D7114358" modified="2013-05-01" version="1">MTEPRQRPRAKGQPIFNQNDLNELLYAFGDSAQPLSTTVTTLDEILADFIIETCHAAALCASYSRRQKIKIDDFRWVLRKNPALLGRVNEQLFREKYIKNQRRLVDFDAYGKEGAAELADIAAAGGADESDLKAGKKGRGRKKKRKAEDEGGAGGSKKAKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M3CY25</accession>
    <name>M3CY25_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_136288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757078.1">
        <property type="nucleotide sequence ID" value="XM_016902766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CY25"/>
    <dbReference type="GeneID" id="27899903"/>
    <dbReference type="HOGENOM" id="CLU_631881_0_0_1"/>
    <dbReference type="OMA" id="FELWIRF"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="303"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="385"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF08957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="434" mass="44521" checksum="416EF3140DE478FB" modified="2013-05-01" version="1">MNLQSRIHLTSSRNHTSQMKLSLAALFAGLVAVATPAKIIKKQTWFTAQRPYPYGIPDYDTPAYGGSPTPSGTTASPPYPTASSSASSEGSPVGVTNSSSVYGSTGFTPLFSSTPRIGTWTTSISTTNISLTWPVTRSESTRPAWPFTTTGSTEGSPVSAGSSSRAWHGNSTITSLLAPTGLTSTLLTTITRNTTVYLSFTSSTGSTAFSITSLPGTGTAYPSLTTPVSSSSVPYYSNDTTTTTTSESTLTVTVTTTLYTTASNSTTTTLDSPIIATSNSSSILTPTAYYSLPYTTLPWTGHSSSSSSSRKNSPIIASSTTTTNSSHPSIGFSSGSRTGTYGFTTSTISHYFPHTYATAGQGSSSTNIEEDSPVSATSRASSGFGTSATPTAYGTGTGTESGDGVLPYGPSSSTEYAGPSAYGAYGVDGDEGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M3CYL7</accession>
    <name>M3CYL7_SPHMS</name>
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        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_127537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EMF09749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016902153.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="27899290"/>
    <dbReference type="HOGENOM" id="CLU_1856557_0_0_1"/>
    <dbReference type="OrthoDB" id="3910921at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="138" mass="15037" checksum="E80340EBE736635C" modified="2013-05-01" version="1">MDKTTFALLLFRAIQVRAPAVRTHHATRQNSDLLTCPCQMLAAALVLSLSISLYRTLHIVTDHYDDKQHLVKKWLNPWISSVGFGAAVGALGMLDAIVGIVSAFLNIVPWVAVLTLDILAAMFFLASGLVSYTSLESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M3CZ90</accession>
    <name>M3CZ90_SPHMS</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_151857</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757097.1">
        <property type="nucleotide sequence ID" value="XM_016907085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CZ90"/>
    <dbReference type="GeneID" id="27904222"/>
    <dbReference type="eggNOG" id="ENOG502RFTY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1541071_0_0_1"/>
    <dbReference type="OrthoDB" id="3633413at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF08976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="174" mass="19673" checksum="B50E3013487BE369" modified="2013-05-01" version="1">MDTQFQRTDQDRTAVLPAHVLSLPHPVRKLLLTLSFEIPIGRQKYPAVIYTAKAGMRSLLAQLSGLRALHFFLNIELTRPPWDHQPSAFDVGCRKGFSGTTTFRHAVSELLDAAQTERPGLEIYLEIKYTYEGTWRGTYMNLPQTYNVAKGAMTSEEVLKAAEAKWTECHFSQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M3CZW9</accession>
    <name>M3CZW9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sugar transporter STL1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_165844</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758305.1">
        <property type="nucleotide sequence ID" value="XM_016908191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CZW9"/>
    <dbReference type="GeneID" id="27905328"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_3_1"/>
    <dbReference type="OMA" id="CYYLAYI"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF28">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="140"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="398"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="14"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="489"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF10184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="512" mass="56565" checksum="CFB749F77EC91A26" modified="2013-05-01" version="1">MAFELRGSKLIAVILLASGLDFLLFGYDQGLFGGILGGKRFKAMLGEPGPTMTGFVTGVYDIGCAIGAVAAFFFGEAIGRKKSIIYANVIVIIGATIQTACYSYAQMAVARVIAGVGVGLSTVAVPILQSETLPSHNRGALLVVQSALIIIGVAIASWLCFATLFANSSLQWRFPIACQILFSLLVLCCCPFLPETPRWLCKHNRIDEARYTISRLLDKPEDDAEVKGQLHEILANIEAENEDGEPSWSEVFSNATKARNLQRVLLGMGPYMMNQWSGINALCYYLAYILETYLDFSQNMSLILASVAFTQYAIFSWPPYFYIDKIGRRWTVMLSSIGCAICMAVIAGCLIKQSYSSAAAAVAFMFLYLDCFTLGILPVSWSYSAEIQPLRVRNKATAVGVFSHWTSNFVVVMVTPIGLNHIGGNYFWIWAIVCASFVPLTYFFGVETSGRTLEQIDESFFENPRILMGLDKKNTVVIKASKQDEESRFRALAKEEEKHPERVSVEQVEEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M3D167</accession>
    <name>M3D167_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_48163</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the avfA family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759344.1">
        <property type="nucleotide sequence ID" value="XM_016909057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D167"/>
    <dbReference type="STRING" id="692275.M3D167"/>
    <dbReference type="GeneID" id="27906194"/>
    <dbReference type="eggNOG" id="ENOG502SRHI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025711_4_3_1"/>
    <dbReference type="OMA" id="NNYKRAM"/>
    <dbReference type="OrthoDB" id="10254221at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004074">
        <property type="term" value="F:biliverdin reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042602">
        <property type="term" value="F:riboflavin reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051606">
        <property type="entry name" value="Polyketide_Oxido-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355:SF2">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="2">
        <location>
            <begin position="28"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF11223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="213" mass="23487" checksum="42CFB9CCC6FE4D4A" modified="2013-05-01" version="1" fragment="single">NSPNTFTIFCRNPSKLPPHIHSLSQPSSSSSSSPAKIQIITGEFTDLSALTRALHTGATILISFAGPAIPAKGTAITEFYKTLFPLIKQDSQTRISRVLVLSTPSFRVVEDKFSLKWWLGVQFVYWLFGDAWEEVNGIGKVVTGLRDEEEDKLEWTVFRVPGLTKAAAGPVRAGFIGERGDGLLLSRKSLAVWILQEVEERKWVGRCPALSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M3D1S7</accession>
    <name>M3D1S7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">4a-hydroxytetrahydrobiopterin dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.96</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">4-alpha-hydroxy-tetrahydropterin dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_14934</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O</text>
            <dbReference type="Rhea" id="RHEA:11920"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15642"/>
            <dbReference type="ChEBI" id="CHEBI:43120"/>
            <dbReference type="EC" id="4.2.1.96"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pterin-4-alpha-carbinolamine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.96" evidence="3"/>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759579.1">
        <property type="nucleotide sequence ID" value="XM_016905499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D1S7"/>
    <dbReference type="STRING" id="692275.M3D1S7"/>
    <dbReference type="GeneID" id="27902636"/>
    <dbReference type="eggNOG" id="KOG4073">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081974_4_5_1"/>
    <dbReference type="OMA" id="HHATMTI"/>
    <dbReference type="OrthoDB" id="277398at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042764">
        <property type="term" value="C:ascospore-type prospore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008124">
        <property type="term" value="F:4-alpha-hydroxytetrahydrobiopterin dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030437">
        <property type="term" value="P:ascospore formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00488">
        <property type="entry name" value="PCD_DCoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.20">
        <property type="entry name" value="Transcriptional coactivator/pterin dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036428">
        <property type="entry name" value="PCD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001533">
        <property type="entry name" value="Pterin_deHydtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12599">
        <property type="entry name" value="PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12599:SF0">
        <property type="entry name" value="PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01329">
        <property type="entry name" value="Pterin_4a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55248">
        <property type="entry name" value="PCD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF11458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="80" mass="9718" checksum="FB57ED9772B8951F" modified="2013-05-01" version="1" fragment="single">WKLTKNKTGIERNFRFKTFKNTWAFMSEIAAECNKPQVRHHPEWSNVYNFTRVRWTTHWPEGISGKDLEMARFCDEVARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M3D2Y5</accession>
    <name>M3D2Y5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NCA2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_150416</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759623.1">
        <property type="nucleotide sequence ID" value="XM_016906159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D2Y5"/>
    <dbReference type="STRING" id="692275.M3D2Y5"/>
    <dbReference type="GeneID" id="27903296"/>
    <dbReference type="eggNOG" id="ENOG502QTT6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008227_1_0_1"/>
    <dbReference type="OMA" id="YHEFHED"/>
    <dbReference type="OrthoDB" id="413313at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013946">
        <property type="entry name" value="NCA2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28234">
        <property type="entry name" value="NUCLEAR CONTROL OF ATPASE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28234:SF1">
        <property type="entry name" value="NUCLEAR CONTROL OF ATPASE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08637">
        <property type="entry name" value="NCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF11502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="689" mass="76197" checksum="64AFBC1663A13304" modified="2013-05-01" version="1">MSFVLDQVRRIDAHFDRLQLANLDSATRVSDSLPAIQSTDDDFSPSQPSRDVPASLPSKRVAALQTAIRGLSPGSADSTSRALLKPSQIQALLSALSPQPQTQAAISLGEGGAAIDGQEKEFFEQELEWLLVSKASTQVYGHVLSSILDEAVRLSDDVWYWDEVLGSQRYTALYSIQVSPLRLWAFGSAVWADAKERAEQKGFGIAGAGKDVKDSATEQWKQFYGLVRQVVQEKSVKEVHKQILSPVTRIRSEVRAKQSALKKVRLRNANALGILLGEGLANESGHADGAASPAKQDVHHKTKASVSRNVALMEAVLAKVNDLETPIAKFFDAIAALTNDDPLYTADSDDVVAPQAVAERLSRVLTLGMGEYAESINALKQQHGKPSRLVRYWLPITASILSSTTVLRILVNRQAEILQWIQNLGATVVDFWQNWVVEPTRNVIRTIRHDEGSEISIVSKRSLEGDRDSLERMVVDFAIDVPATATETGAPLTEAEISSIRAKVREGDLTPVLKAYEKDLSSPLRGAITGNLIRALLIQVQKTKVDVEIAMGGIDSLLKSQELLIGFISLTPGLLVAYAVSRWVRTSFTEKRGTKAERKHGVMLRQLRNIDRILTSASPTYEGELPYKDQGLLLCEIHVLRQAAVKVMPWQIYREFSEEAEELCDVRKGVQRQKAVLGRVRWAYMRWLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M3D3T0</accession>
    <name>M3D3T0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NYN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_149403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760986.1">
        <property type="nucleotide sequence ID" value="XM_016905531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D3T0"/>
    <dbReference type="STRING" id="692275.M3D3T0"/>
    <dbReference type="GeneID" id="27902668"/>
    <dbReference type="eggNOG" id="ENOG502S3QT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023133_1_0_1"/>
    <dbReference type="OMA" id="NIFIGFM"/>
    <dbReference type="OrthoDB" id="5590473at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18724">
        <property type="entry name" value="PIN_LabA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007681">
        <property type="entry name" value="Mog1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15837:SF5">
        <property type="entry name" value="NYN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15837">
        <property type="entry name" value="RAN GUANINE NUCLEOTIDE RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="577"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF12865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="725" mass="78276" checksum="ED7B9BBD4E740AA2" modified="2013-05-01" version="1">MSTLTETKPWDLSHVLDFVNALATPGQHQKDTVPTTRLAPSASHPANVVSNNASLTDTADDDDAHGGVGLGNFGKVWQFLGTPAPTQGTSLLATKTGQVEKQTIASKLDYTSDGAAYTLSRGEPSSANRHPSFTDGTDGETQRPEFEKAPSKTQKKRMRRKERREQELVQARLNGGRADAISESEAETPGRRTPAKKASAHAMKEKEPGTPSKSKFDKTELLRRVAVTKAAQTAKTAAVTNASTQQGPMGPGLAPVLDLPGTKQVPIQNATEQTVPANVSRQTDPSSASRSDAEETTSQAVNAVAAALAALKHGDNPASPSPSGTGSRNKKAPSTPTQTKAQPVAQTQPVQRTQVQTPQAVSKLKLMPASVGVQPPLAKGLANNGHAPAAGINPTAFAQSMHIPSGPPSMRLSTIPSSAKKPRSQPVIEPRIIRSGEDRHWALLMKLINVFGDDRKHLVSPMNMTTHNNDPKGIHVFVDASNIFIGFMDMLKQTRGIHPLTHLPQVHLSFDGLALLMERRRPVAKRVLAGSNPWLPEFDKAKAVGYEMNIFEKVLKARELTDRQLYFKDLDARRFGKGSKAPPPVHPSNQITKQGSPPKLYSALNGIGSGSGSGTETSAKPQYAPAKMIEQGVDEILHLKMLESVVDYETPSTIVLATGDAAQAEYSLGFMAMVERALKKGWTVELVSWSKNINKSYIKSQWTEAWDGRFKIIYLDDFAEELLDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M3D490</accession>
    <name>M3D490_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Oxidase ustYa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_45138</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760830.1">
        <property type="nucleotide sequence ID" value="XM_016908952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D490"/>
    <dbReference type="STRING" id="692275.M3D490"/>
    <dbReference type="GeneID" id="27906089"/>
    <dbReference type="eggNOG" id="ENOG502SQBY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042941_4_1_1"/>
    <dbReference type="OMA" id="WGVVHSC"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF4">
        <property type="entry name" value="CYCLOCHLOROTINE BIOSYNTHESIS PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF12709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="26797" checksum="0402CF8CE41E07D6" modified="2013-05-01" version="1">MKYLPFALFNITLGLATGYWLAGLKSGSSSSNGINTTTTNELGPEPSALQQIMRTRHDVPFSPNYHYMGPSAEVKANWMALTKSQDSIYLSNPHAFNIQDAGIRAPFFTFIDPPPAAAKAPNLLNFYVLSNLHQLHCTHMIRTRYNELVYDKIDPFKDTSFDRNWITHVEHCFEYLRLSITCGDNMVFESDSPPGSPKEFWEDGLSWGVVHSCMDWEGLMEWQEQQLVLYNSTWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M3D4U9</accession>
    <name>M3D4U9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_148596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761351.1">
        <property type="nucleotide sequence ID" value="XM_016905020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D4U9"/>
    <dbReference type="GeneID" id="27902157"/>
    <dbReference type="HOGENOM" id="CLU_1042687_0_0_1"/>
    <dbReference type="OrthoDB" id="10339616at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF13230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="267" mass="30422" checksum="7BAA6EC371AF8356" modified="2013-05-01" version="1">MTPFKQIRAFIVRCSPRASRARQKLRVEAAAEQRLSSRDLDMQLSPTLEQASASFSEWTDEGESGWNGEPPELQYSSSPIKYDTHRPATARSNRGVSPTPKGRGVCRQQVLDSAHLTALNHQLAAYLEKAESDLSRKHIVIAEMEDDLNALWETAIKHQSKHLELKQENARLTEVVGLLTTSKWRPMRELKRRLLHVESRATIAESQVARMKEVLAAQVKERTELHKEAYELWDAILMTGEQAGARDRADRAMDRLSIRFDFEDGHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M3D703</accession>
    <name>M3D703_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histone deacetylase complex subunit SAP30 Sin3 binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_155905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761780.1">
        <property type="nucleotide sequence ID" value="XM_016907649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D703"/>
    <dbReference type="STRING" id="692275.M3D703"/>
    <dbReference type="GeneID" id="27904786"/>
    <dbReference type="eggNOG" id="ENOG502RZ9X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090091_1_0_1"/>
    <dbReference type="OMA" id="HARSMKN"/>
    <dbReference type="OrthoDB" id="510958at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038291">
        <property type="entry name" value="SAP30_C_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF13659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="170" mass="18655" checksum="09FCDBB355CA12AC" modified="2013-05-01" version="1">MPPKAPQDARSDNLTIKERQVAAAAHARASKQKGQASQPHGTMRYGDLPRISNGTGPAPQPAAGMQWEQMPRTVLEVYRVAHNLDTPASFTSPRNQALLTNPGIGRHSPTMRRAKHQQRQSEVKLATQVRKHFNAAAVNETEVVAGMQYVAKNKDKAFKQKSTPNATKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M3D7N9</accession>
    <name>M3D7N9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6987 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_149029</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762010.1">
        <property type="nucleotide sequence ID" value="XM_016905294.1"/>
    </dbReference>
    <dbReference type="GeneID" id="27902431"/>
    <dbReference type="eggNOG" id="ENOG502S06V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001289_0_0_1"/>
    <dbReference type="OMA" id="CDAEGQF"/>
    <dbReference type="OrthoDB" id="3937590at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022124">
        <property type="entry name" value="DUF3659"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054256">
        <property type="entry name" value="DUF6987"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39461">
        <property type="entry name" value="LEA DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G04920)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39461:SF1">
        <property type="entry name" value="LEA DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G04920)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12396">
        <property type="entry name" value="DUF3659"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22485">
        <property type="entry name" value="DUF6987"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="2137"/>
            <end position="2155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="2167"/>
            <end position="2187"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6987" evidence="3">
        <location>
            <begin position="1991"/>
            <end position="2186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="817"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1043"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="253"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="829"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="863"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1054"/>
            <end position="1075"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF13889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="2216" mass="235934" checksum="37C7880943E122EE" modified="2013-05-01" version="1">MSSNSKQYAYYSFPPTPTRTSPSSRRRNDSRSNSTSTNRSLYEMAPSPAAGKQTSSSSMPKTPTKLQRKPGQTPQRPGQASASKTPSTPKATQSTPKATQSTPKAAQSAKSETDSPKPPAKPAAGQKAEQAKDQAGSTADDIKQQTGKAQSVAQSSATDDDDEEPLSKVSQAGQQSKESLQPQTPEPIPDDDDDDDDEKEDDDENDDEDAVTGAQEQAHGAAGKVEDDAESTADDATEKAGDTIQSADDEDGSSQQSQQLPQQGKKGNGLLSGAKGLAGKAGSLADKASKDPKSATQQAPQDTKKGIEDTAKDSQKGVQNVQDTADDGVEEGQKVAGETTDEAEDATEGLQDSAKQAADKTGKTAQDATGDAEDAASDAKDSAEGAVGDVKDSTEHAQDQAEDATEDAKDQVKDSADSAKSQADDTAADAKDSAEDVADDTEATAGAAKDQTDATAESAKEEGESTIESELPVPEGLPVDLNVLKGLEVQEDGTVLDKEGNPVGRLAEGDAEDLAGYPIGEDGEILDDDGDLVGRVELMPEEIKRQLQETRESGEELPEDAQTYLGQLEDQAEEQVDDAEEEVDGDLPSLSIMEGLTCQVDGLIYDAEGNTIGRVTDGDPQKLQNAVLNAKGEFIDQDGNVVGRAEIHEDTEELVEQGVYEPAKQAAADADDRIDSGQEEGVDAAKDVAGEAEDAVPTEIEDQLPGIEALQGKELNEAGEIVDEEGNILGNIADDSEDLKKKIEEGKVDPETLKIDEEGNLVDEEGNVLGKTELAEGAAEKLQQLSKLQDLRILNGKRLNKKGKIIDDEGEEIGELTDGDLAEAAGGRANDKGEILNKKGEVVGHVRVVPGDAAEQATKELLEELGENVEEDADEEEKEEEEKVEEAEQGEEGEGEEGEPEQEEPEEEESGEEEPQYEEPELNILDGLKVNKKGQVLDEEGEPIGELTAGELSKCAGKKINATGEVVDKDGKVLGHVRTLPQKVEPVEEAPAVSVLEGLKVNKKGLVLNEDGEQIGELTSGDLSKVAGKKIDAKGQVLDDKGEVIGTVRTLPTDDQEEEQPEEQAEEEEEEEEDKDATQLPPLSALEGLSVNKAGKLIDGNGAIIGELTEGDAKKLSKSGLTADAEGQFWDNKGHVIGRAKTLPQEDPEEEAPFAGLEGLRVVEEGWVQDAEGHTVGYVTEGEAAKLIGRAVDEDGDILDKKGSVVGHAERYVPEEEEEQPEEKPDLSFLEGKTVTKQGLVIGDEGIPVARLVEGSAKELAGRSLDKEGQFWNDKGSVIGKVELIPEAEREAKPEGPFAGYDDLRVVEGGKVADEDGNVVGEIVEGNPKRLVGLSVDEDGDILDKYGNVKGHAEPIPDEDPIDYSILDGLTLNKAGFVVDESGIPIGKIVEGSPSDLAGKKCDENGYIYNDTGKVVGRCEPLPEAERQKKAEGAFAGLEGLHVVEGGYVQDAEDNRVGQIVEGDAKKLIGMKVDEDGDIIDKFGNVKGHAERVEEEEKEIDYSILDGLTLNKQGLVVDQNGTPFGRLVEGQASELAGRQCDEQGYIYNDRGKPAGRAEPIPEEERVARPEGPFAGLEGLHVVKDGNVEDENGNVVGHITEGDPKRLVGLKVDEDGDIIDKFGNTKGHAEPLEEEEEKPVDNSALEGKYLNKQGYVVDDKGIPFGRLIEGNVSELAGRKCDENGYIYGDTGKVVGKCEVLPENERVARPEGPFAGLEGLRVVKDGYVEDQDGNRVGQIVEGEAKRLVGLHVDEDGDIIDKYGNVKGHAEPWQEEDEQAADLSRLAGTTINKAGYAVDGSGQIVGRVVEGDPNIMIGKKVDKEGQIWDDAGNVIGQAEIVTGVNSEEGPFAGFDNLVINKDGTVTTEAGDIVGRVTEGDIKKLLGHTVDEDGDILDKNGNKIGKAERWEPEEKERRINPMSGKRVNKEGEVRDDNGDLLGKLTQGDLGHCVGQEIDDAGNVVDVEGNKIGEVTLIENIAEDEYEGPTQEELDEAAKREEEREIAGKMGTICQQTLEKMQPICKQIKEHMEKADSTPKEELDEEELVNQVKPLIEEGGRILQECNGSLRGLDPDGKIAAQAKGRAGTGEATPEEFRLAETLKELTTTVVTTIDDAKKKLNNMPHAKKKLNPLWSLMTQPLFQILAAVGLLLAGVLGLVGQLLNGLGLGGLVNGLLGGLGINKLLASFGLIDGDKDKKKGSGKSKLSSIPVVGGLLGGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M3D9K1</accession>
    <name>M3D9K1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WKF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_140289</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">SO2202</strain>
        </source>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019327">
        <property type="entry name" value="WKF"/>
    </dbReference>
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        <property type="entry name" value="CHROMOSOME 7 OPEN READING FRAME 50"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CHROMOSOME 7 OPEN READING FRAME 50"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="190"/>
            <end position="252"/>
        </location>
    </feature>
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            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
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            <begin position="328"/>
            <end position="496"/>
        </location>
    </feature>
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    </feature>
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        </location>
    </feature>
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            <end position="362"/>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <sequence length="496" mass="54979" checksum="60834863B7A86228" modified="2013-05-01" version="1">MPQKRNLESQQAEIPVKRAKVELAKPVSQSKSKPFPGSAPKTRTAGQQVWNDEERSSLPAPTGVFKAPGQVAKRIVFGDDEEEDVPSPPKQTRPGSIRKSVSFTPETKQEDTFSAQSLIQAWEAEEDRAEAVTRVSTEPPASVSEVSKEPKAKKEKKKKRVKASPAARVEEFKSDEDIKPSSEEVPSYVKYLEQFSQDKTNWKFNKNRQADLFRNLFDIDRIPSRYNPALVQYVSSTQGQARRRIAEQAEDVLKAIWVRENDNSDLMSLDTPEARRAAYYEALQASIDRYEQSGAGRTEYGDQQLKEILREHEKGKRAEEMLSKALQGELWPEEASTSAAATTGSTTNVSATTPSTSTSSTTIPRATRVIETQRIEGGQVTTREIHLTNNNDNNNNKPEPKRKRNRKSRTDVSSSSDSSSSSDSSDSASDDSSDDGTNDNSEDDSRSSSDASASSPASKKKRRTTPSKTKAVTPTLPPLFDSDVLDKKFGKAERHS</sequence>
</entry>
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        <name evidence="3" type="ORF">SEPMUDRAFT_146909</name>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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                <person name="Grigoriev I.V."/>
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        <property type="project" value="UniProtKB-KW"/>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <sequence length="518" mass="55418" checksum="5315BB856AE6B284" modified="2013-05-01" version="1">MHNFISLLPFSLLSLLQLASSAPVEKLLTPPAVEVVVRDYNTLNATTWNGLPGPPVTESTDLDSSSSINNNAAFAVKVLPEATATSTNDNATTGGTGRLIPNPLARMVASANLTSSSASRLPPDADPLATAAASGVLTLSIVNKWPSEKVHVYVTGLDPRGALVMLGQDGRYLYPTTYSTTPVEVTGDIAIPVGKPNTTLALTLPDYISSSRVWVVDGFLQFYVVATPNGPGLVEPSAVNAADPSSQKNYGFAELSYAASYGIYADITAVDFVGLPLGIELESANSRKQSILGTPANAATTLCNSLTAQSKKDNQPWDQLCVRDSNNKLVRVLAPSNLISQRPSAFRQYFSRYINNVWTKFSQEDLIINTQTTAGNVTCRVRNNLLQCAGDNRAHTKPVAADIFGCDSGPFLVQPTDNAIHLAVIPRLCAAYNRATFFLTGGNIQPNLGPEDYYRSPRAGPNVGGPKNWYSKFVHDIEAEGRGYAFAYDDVAPRYEVDQSGLVASTTPRLLRIIVGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M3DA28</accession>
    <name>M3DA28_SPHMS</name>
    <protein>
        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_146949</name>
    </gene>
    <organism evidence="5 6">
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            <taxon>Mycosphaerellaceae</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
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                <person name="Kosti I."/>
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        <subcellularLocation>
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        </subcellularLocation>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Nonsense-mediated mRNA decay factor"/>
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    </dbReference>
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        <property type="entry name" value="Upf2/Nmd2_C"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12839:SF7">
        <property type="entry name" value="REGULATOR OF NONSENSE TRANSCRIPTS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Upf2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIF4G" evidence="4">
        <location>
            <begin position="36"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="MIF4G" evidence="4">
        <location>
            <begin position="470"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="MIF4G" evidence="4">
        <location>
            <begin position="675"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="244"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="426"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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            <end position="994"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1019"/>
            <end position="1050"/>
        </location>
    </feature>
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        <location>
            <begin position="1105"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
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            <end position="269"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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        <location>
            <begin position="951"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="973"/>
            <end position="994"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF14925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1144" mass="129317" checksum="DC25B4DA1E62B563" modified="2013-05-01" version="1">MAAMERRRKRDLKEQNVRAWNGEHVFDVQGSLDSNMKKNTAFIKRLRTAITSSNTPTFLQEIRSLSLHKYLTEIISACYEGLTKLKVAADISAGVEIISALHQRFGPDDFTSYLGWYVGRGLATPDRAQLKALAADVREREEKDRILRQRTLLRVATELWLVGVLKSLEDIAQPAEAGKVGKGTEGPVKPKVNGTRPDVADPEPFPLEVLKDMLSHDREHVNLPLVVLFVKTFAWDILGSKHGKTEGRQKIADDGATTTVSGNFDSATSTEHDDGSTPDPPLTPPELQQRFRNILQRYFDDVKAHILRDQQRLTAQGKRNAEAYVKSGEVFEDRQTNHEKAQKSQEKLVSSAQTLAEVLGAEMPDLSEKDSSHAGLEGSIGLVKTGEYLRGQAEGAGIWEDEDERRFYENLVDLKDRVPGILLEDSKKKKAENDEQVGKKVEEGADAKEKPMGSDESSTAIANKTVGAQVDALLARLHELSTKDQVDQLAIDFCFLNSKASRNRLVKAIEDIPKGRTDLLPLYARLIAILGRHLQDVPEAIIKYLDDEFRSLQRRKSKDFLGQVRMINMRYIAELTKFGVVPEHVIFHCLKVCLDDFSRMNIEIIANLLENCGRYLLRNPETSPRMASFLETLQRKKTAQHIGQQERMLVENAVYYVNPPERAAIQQKERTTLDLFVRKLVYTDLSKKSLDKVIKQIRKLHWEESEVVDVLRKIFVKPGKIRFGNIFLLAMMLAALYRFHTGFAITVLDELLERVTVGLEINDFKYNQRRIAEAKYLGELYMYRVVDSALIFDTLYKILNYGHATYAQPGEVCAMDLPDDYFRIRLACALLETCGHCFEKGAARKKLDFYLSFLQYYINVKDPIPMDIEFVVQDTFNVLRPQWKLVLNDFPEAARIFGEACKQNYQDTAAGKMQEAEEPEDPDADVTLSDDEHREGEEHLADGDNAPSGSDDGKAQGDDDEGRANEQSDEEEHIVVTRPEDHRDPEADAEFDRELAKLMAESVDSRKFERKTAFDLPLPMRRTVRDAATPAAAGGDEETPAPPSTNGAGTMKFALLSKKGNRQQTRSIDMPSDSAFAVAMRSQQEAERAEQQRIKNLVLNYDLTNDQEDGSFESLHNGPRYDKSGNTRSKQRARKLQLGDIDWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M3DAV4</accession>
    <name>M3DAV4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_147146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763336.1">
        <property type="nucleotide sequence ID" value="XM_016904112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DAV4"/>
    <dbReference type="STRING" id="692275.M3DAV4"/>
    <dbReference type="GeneID" id="27901249"/>
    <dbReference type="eggNOG" id="ENOG502SS7G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048145_0_0_1"/>
    <dbReference type="OMA" id="FEGHRRT"/>
    <dbReference type="OrthoDB" id="4121058at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF15215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="464" mass="51379" checksum="1D6020481D838682" modified="2013-05-01" version="1">MDAASPIVRGEFLFRDVLLVDCGGDLKRHSRATEQEIKTLLTGKNVKDQVGHWWEAQLIHYGLQRSKQKDTAKVRLQQALQLGKLKFQPPHLASMEAQMKKEYIAAVRKAMKPKPDAGKGAKRAREDEANSSVKRTKISVRVGDVHVDIDHSDAATTKKQKTTKSAASKSGNIDHSEAATTKKQKVAKSAASKQVDIDHSDAASTKKQKTTKSAASKPGKSSTPIDSPVPKGRGVAAKPKTARKQADDVPFSPENVFQDSASKPKASTSIKPKPGIKKEPRPKQEPAAVESSPPVKHEGYLFDADAMDTRADIAQEKLTITGVYALHCPQITEQLEEHSDDLRLFMCVDQETGVTWGGFQLAMKSGVIRLDDIDINQRLTFGWRARDTWRRDLRFGQKCFGEIEFDGAGGVRGTFYNMFAKMEGVGEEACEFEGHRRTGPLWSGRPAHSYKQEWDNFPKIAYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>M3DBI2</accession>
    <name>M3DBI2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="17">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">SEPMUDRAFT_147150</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="function">
        <text evidence="16">This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports the calcium to the vacuole and participates in the control of the cytosolic free calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 17">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="17"/>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763340.1">
        <property type="nucleotide sequence ID" value="XM_016904116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DBI2"/>
    <dbReference type="STRING" id="692275.M3DBI2"/>
    <dbReference type="GeneID" id="27901253"/>
    <dbReference type="eggNOG" id="KOG0204">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_9_3_1"/>
    <dbReference type="OMA" id="RRSVVFN"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02081">
        <property type="entry name" value="P-type_ATPase_Ca_PMCA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000028">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000018">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF346">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 17" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 17" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 17" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="479"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="904"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="930"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="974"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1012"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1050"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1084"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="21">
        <location>
            <begin position="202"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="19">
        <location>
            <begin position="303"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase C-terminal" evidence="20">
        <location>
            <begin position="932"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1142"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="86"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1150"/>
            <end position="1163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00059328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EMF15219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1176" mass="127150" checksum="305806B25A16D497" modified="2013-05-01" version="1">MAGTPLPRIDVEVSADDSNDINPTPTTLLPGSRDRAPSSPTMLQTPTWNGRERSASGLSGSTQYSTLKVPDTSYGEKGSSTSSIFSHEEREDALKPDPGTEKDFQVKDNKFAFSPGQLNKLLNPKSLGAYVALGGIRGIERGLRTNLQTGLSADENKLDGRVTFDEATQYAEKSKSLGWDEVTVNPTARQAASAPVTGSYDDRHAVFSNNALPEKKATSLLKLMWIAYNDKVLILLTVAAAISLALGLYETFGAYHPPGSPEPVDWIEGCAICIAIIIVVLVGSLNDYQKERAFVKLNAKKDAREVKVIRSGKSLQIPVQDITAGDVIHLEPGDMVPVDGIYIGGHNVKCDESSATGESDALKKVGGEQVMRMLEEGHTDLKDMDCFIISGSKVLEGIGTYVATSVGVNSSYGKILMAMRVDMQPTPLQVKLDGLATAIAKLGTAAAVFLFFVLLFRFLGGLSNNPRTSSEKASQFLDILIVAVTVIVVAVPEGLPLAVTLALAFATTRLVKLNNLVRILKSCETMGNATTICSDKTGTLTTNVMTVVTGTFGERSFDDKNKTGSETTSAAFVEQLSADERRRIVDSIAINSTAFESDDGSFVGSKTETALLALGRTLGMGPVAEERSNAEIVQLMPFDSARKCMGAVQKLSSGTYRLLIKGASEILLGHCSTIATSTGAIPLDGAERERLESIIDSYAQQSLRTIALISREFTQWPPAGCNVENDPQSADMDLVLKEMTFDGLVGIQDPVRPGVPEAVAKCAYAGVSTRMVTGDNVVTAKAIATECGIYTGGLVMEGPVFRTLSEAQMDECLPKLQVLARSSPEDKRVLVVNLRRLGEIVAVTGDGTNDGPALKAADIGFSMGISGTEVAKEASAIILMDDNFTSILTALMWGRAVNDAVRKFLQFQITVNITAVIITFVSGVASSEMIPVLTAVQLLWINLIMDSMAALALASDPPTEEILDRKPSKRTAPLISVIMWKMIIGQAIYQLVVTFILYYAGPMILNVERDGSEIRSVVFNTFVWFQIFNMLNNRRLDNKFNIFVGFFRNYFLIAILAIMIGCQVMIMYVGGRAFSIQRIDGRDWGISIVLGGLSLPWAVLVRLFPDNWFTAIAKFCGWPVVQVYRPLSRWTHALSKKIRGLRRSKKESQDVASEAESQEAVVEAENKTKLPNGSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M3DBQ3</accession>
    <name>M3DBQ3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_59928</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763405.1">
        <property type="nucleotide sequence ID" value="XM_016909511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DBQ3"/>
    <dbReference type="GeneID" id="27906648"/>
    <dbReference type="eggNOG" id="KOG1282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008523_10_3_1"/>
    <dbReference type="OMA" id="HYGPIFN"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF64">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032362" evidence="7">
        <location>
            <begin position="23"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="571"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF15284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="591" mass="65335" checksum="0C873000D39C97A3" modified="2013-05-01" version="1">MASLLLGASSLLAVLTAPAANAQFVTPPTDLTDSKGYLDIPVRFKEVPEGICELTPGVKSYSGYVDVFEDQHVFFWFFESRQKDPENAPLTVWINGGPGSSSMIGLFQELGPCGVDANGDVYNNPYAWNNASNMLFIDHPAQVGFSYSTPIPGYQTSSDIIQLPSAECPDYAAGTCGTYSYPNQTDTANSTINAAPSMWRTLQGFMGAFPQYSRNEFNFATESYGGHYAPIFNSYIESQNALIKDEKLPGAHHIDLTTVLIGNGWYDPLTQYEAYYNYSVYPGNTYDYDPYNQSIKDQVYNSMYGTGNCYDQTVDCNTRGINEICTAADNFCATEVEFVLDSVTGRDEYDIRELTPDPFPYAFYVDYLNTPKVQQAIGAYVNFSESNSAVSNAFGSTGDDDREEGTIEAVRKLVNNGIYVVQYYGDADYNCNWLGGQAVSKLIDAPGFTSAGYENFTTSDGIVHGQVKQSNNFAFVRVYESGHEVPFYQPVLSLEMFERAIDGKDIASGTESCFEAYKTVGTAESTYREGNRTVQFTVLPIDSTYNTTTDAPNFVNGTSSAISARRSVNMKRTGSRKRAFKPSFQSRNQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M3DC69</accession>
    <name>M3DC69_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PIN domain-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_147302</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPG/RAD2 endonuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763525.1">
        <property type="nucleotide sequence ID" value="XM_016904212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DC69"/>
    <dbReference type="STRING" id="692275.M3DC69"/>
    <dbReference type="GeneID" id="27901349"/>
    <dbReference type="eggNOG" id="ENOG502QVHA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_378548_0_0_1"/>
    <dbReference type="OMA" id="RFYQTKV"/>
    <dbReference type="OrthoDB" id="17262at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09858">
        <property type="entry name" value="PIN_MKT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022039">
        <property type="entry name" value="MKT1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022040">
        <property type="entry name" value="MKT1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF32">
        <property type="entry name" value="POST-TRANSCRIPTIONAL REGULATOR MKT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12246">
        <property type="entry name" value="MKT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12247">
        <property type="entry name" value="MKT1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Post-transcriptional regulator MKT1 N-terminal" evidence="4">
        <location>
            <begin position="305"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Post-transcriptional regulator MKT1 C-terminal" evidence="3">
        <location>
            <begin position="483"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF15404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="744" mass="83342" checksum="752C49AB0BC2905F" modified="2013-05-01" version="1">MAESLAFREWAKQEDLIYTVPIGQFENSTIGYDAEDFVNILLSAEGREPLLPALGGLPFTLRTNIDRELENVEKLTGNKPLFMFNGIDLAFHDRKTISKESDKAVRILDEAWRVYENGDGDAAVRAFEKACTYRTTHILRYLYHYLHEKGAHVMVAPYNAAAQLVYTDNHKGISACHGSASLLAFGVDKMILYFDWENQEAKYIDREHALQRLMMTQEQLTDLLLLSGSIIMPPVPEIVREGQVPSIAAARQVLGQAGMDGIQAVKQTKDKEYFALFIKAKIAVRHMVICTASGDYTQLDLEHAPSDLAMIIGTRYPIELYHYLQRGMIGPRILDWRARKEIFISAPLDGGSSATYKELVQKKLQPLHLRTLTLLSSRLQRYYHNTNIDLFCWFDEKPISLNIKAQSQIESSGKDAETWHVRDQLRTQSNAARDIDLNETPIQYAITWLSDNALAKKSHTKRGKEDHSMLSTPAELLSNITWRFLHDRGYINTSDHTLTAWGKALMAAFDQAKAEGYLGSTDPTREAEEAIFVAFELLRLDLLNGKDLFPGVSGGASRGTDQDKANVQLISRVSTLGNFKHQSIGYTGPLSRNTLAYHQVAAAVRNALRDLVEVHAVNLMLAGSAVRIRNNEEYIEVGGRLPFLKEPDLGLALVVKSYLDELCQPPERRADVKKWFSHAEDIDGDIGRAWKLWSAINAGIQAADGAIVSQEVRDSFENANTWLQEKRASAAAEPSPHTNGTNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M3DEY4</accession>
    <name>M3DEY4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]</fullName>
            <ecNumber evidence="10">1.3.1.88</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">SEPMUDRAFT_147753</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs. Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>5,6-dihydrouridine(16) in tRNA + NAD(+) = uridine(16) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53380"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:53382"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>5,6-dihydrouridine(16) in tRNA + NADP(+) = uridine(16) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53376"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="13">
            <dbReference type="Rhea" id="RHEA:53378"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>5,6-dihydrouridine(17) in tRNA + NAD(+) = uridine(17) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53372"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:53374"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>5,6-dihydrouridine(17) in tRNA + NADP(+) = uridine(17) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53368"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="17">
            <dbReference type="Rhea" id="RHEA:53370"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="14">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="16">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Dus family. Dus1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.88" evidence="10"/>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF16084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764205.1">
        <property type="nucleotide sequence ID" value="XM_016904504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DEY4"/>
    <dbReference type="STRING" id="692275.M3DEY4"/>
    <dbReference type="GeneID" id="27901641"/>
    <dbReference type="eggNOG" id="KOG2335">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013299_5_1_1"/>
    <dbReference type="OMA" id="RPWWICQ"/>
    <dbReference type="OrthoDB" id="272303at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082">
        <property type="entry name" value="TRNA-DIHYDROURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082:SF5">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(16_17) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="19">
        <location>
            <begin position="25"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="327"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="559"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="289"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="327"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EMF16084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="584" mass="64936" checksum="658E77A3E762537C" modified="2013-05-01" version="1">MSSSSSAKLHGRAFYESIGSPKYVVAPMVDQSEFAWRLLTRSFLPAELRSSILAYTPMFHAKLFSDNPKYRANHFEPLKPPITMADPPDAEHIKTMGEADRYLDGNPNMDRPLFVQFCANDPDVFLKSAQMVAPFCDAVDLNLGCPQGIAKRGNYGAFLQEDWDTIYKLINKLHKNLDVPVTAKFRVQETREKTLEYAKMILSAGASIITVHGRQRHQKGHETGLADWAVLRYLRDNLPKDTVMFANGNILQHGDIEKCLEATGADAVMSAEGNLYDPSVFTQGPPAGEEGREYWRGRDGKGGYRADAVLRRYLDIIHKHVLNQEPPQREDLFLPTDPRPETVEDTQTTSLKRSAEDSASGQAPTKKQKREAAKEKKKNGTKPEKCTNANLTAMQPHCFHILQSLVSTHHDVRDALARCRAGDIDAYENVLKLTQEAVKVGLLAYEKDPAQFETPDVPDEEDADPELSSTAAVRRCKRPFWVCQPYVRPLPKEALEKGSLMLSKKEKARLAAEQAEREKAGVSADGHIEVVKSAKVNGATPIINDVPENFHAANAKLDVGDSTQTASGDQEERTEIPKEGMVMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDF5</accession>
    <name>N1QDF5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Uridine kinase</fullName>
            <ecNumber evidence="6">2.7.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_151442</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>cytidine + ATP = CMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>uridine + ATP = UMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16825"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the uridine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.48" evidence="6"/>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757536.1">
        <property type="nucleotide sequence ID" value="XM_016906826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QDF5"/>
    <dbReference type="STRING" id="692275.N1QDF5"/>
    <dbReference type="GeneID" id="27903963"/>
    <dbReference type="eggNOG" id="KOG4203">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021278_0_2_1"/>
    <dbReference type="OMA" id="EPQLHCE"/>
    <dbReference type="OrthoDB" id="738517at2759"/>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00637"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00579">
        <property type="reaction ID" value="UER00640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043771">
        <property type="term" value="F:cytidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004849">
        <property type="term" value="F:uridine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044211">
        <property type="term" value="P:CTP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02023">
        <property type="entry name" value="UMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000339">
        <property type="entry name" value="Uridine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000764">
        <property type="entry name" value="Uridine_kinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004018">
        <property type="entry name" value="PRK05480.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00235">
        <property type="entry name" value="udk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00988">
        <property type="entry name" value="URIDINKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="35"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF09415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="467" mass="52613" checksum="17484663409FD81B" modified="2013-06-26" version="1">MNIPSLELPLGAFAALDTPKTTSSTRAHYSPPWADTSIIGVAGSSGSGKTSLSMAIIRELSLPWVVIMSMDSYYRPLSPAQSAAAFRNEYDFDAPEAIDFDKLVENLRDIKAGKKTDIPIYSFEKHARVDKTNTIYSPHVLVLEGIFALHDQRILDLLDLRIFTEADADLCLSRRLLRDVRERDRDVEGCIKQWFNFVKPNFHKYVEPQRNVADLIVPRGIENKVAISMVCDRVHRTLDEKSRQHQLELRRLGQTSEDATMSSNVAILEPTNQVRGINTILMDPGLEREDFVFYFDRIAVMLVEQAFASGMCYKQHVVKTPMSGQVYHGLAMDGEISAAVVLRGGTCLETGLKRVVPDCRVGRLLIQTNFRTGEPELHYYKLNPDVQDHKRVLLLDPQMSSGGAALMAVRVLLDHGVKESHIVFVTYMAGRDGLNRLMSVYPDIKVVLGRIVDDSETRWVEERYLGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDH1</accession>
    <name>N1QDH1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_52028</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757571.1">
        <property type="nucleotide sequence ID" value="XM_016909212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QDH1"/>
    <dbReference type="STRING" id="692275.N1QDH1"/>
    <dbReference type="GeneID" id="27906349"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_18_0_1"/>
    <dbReference type="OMA" id="MWWSTYE"/>
    <dbReference type="OrthoDB" id="3632335at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF309">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="159"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="383"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF09450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="463" mass="50725" checksum="D7F5DD22E79DE08F" modified="2013-06-26" version="1">MRIIIVGAGVSGLSTYLLLEKLLPPILGKTTRKLEFLIYDSHISIPAGAGSGAGPIGNTSILPPTSIKILQQIDPELYTLFKSQGFENHAFTIRSARGYTLAKLPTTTTTTATTATVDQKEEYAISCPHAVLKECLREIVGRREQPILHGKVIDVELGGGKSPDGNQKPRVKFSDGRPSVEADLVIGADGVHSVVKRAVFGQEADEKHYAPEFEGFGGVGSFIKMDNSKEKKKDEESVPDIIAKQKSAVVTFGPTGSFGYAAVSPLSACTTLGWWSNWPSEEIPSPESTDAAQVQKQLEQRHGTWKDPIIQKCISASNTSSVYPLWTTPKLPHWGKGGCVLLGDAAHTLQATSGQGAAQALEDSVTFSLLLTHYLSESLQEEETSLDDFDDDDDQRSTSSHALAQSIDSATKALYELRHERVANIKTQTRNLYFGRRKITTLWWEYTYYCFLFLVTNFPRIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDH4</accession>
    <name>N1QDH4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_120306</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757572.1">
        <property type="nucleotide sequence ID" value="XM_016901588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QDH4"/>
    <dbReference type="SMR" id="N1QDH4"/>
    <dbReference type="STRING" id="692275.N1QDH4"/>
    <dbReference type="ESTHER" id="sphms-n1qdh4">
        <property type="family name" value="Hormone-sensitive_lipase_like"/>
    </dbReference>
    <dbReference type="GeneID" id="27898725"/>
    <dbReference type="eggNOG" id="KOG1515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_787138_0_0_1"/>
    <dbReference type="OMA" id="PAHENSQ"/>
    <dbReference type="OrthoDB" id="433474at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="117"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF09451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="372" mass="41305" checksum="0EC64245E32D9997" modified="2013-06-26" version="1">MLLPGRLGNSQSSLATDPRTHRGLLKGLEAYEMQYNTFLTANITPDASLAEIIAFAHESEKALESMIHGMDFGVLHPSQQSPITVTQVFIPGVNENQIQLSIYRPAHENSQEELPAVLYFHGGGMVMLSTQNRLHTSYAEAIARTGLVAILVDFSNVLSNGNPEASSHTNLNPFPTGLDDCVSAARWINKHKQDLRISKIVLHGDSGGANLALATALRLNISENTKATIDGVFAVDPYISGAYDQSREWKLKNLLQSLVECDGYDVSCSSCSIYARLYDHQGKFRNDRFAWPYWAMESDLCGLPPHVIMVAELDPLRDEGIEYCRKLVRAGVRSVGRVRLGMTHTGDLLLRQYVPDEFLELLDMLRGFVDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDQ0</accession>
    <name>N1QDQ0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_135999</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757772.1">
        <property type="nucleotide sequence ID" value="XM_016902747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QDQ0"/>
    <dbReference type="STRING" id="692275.N1QDQ0"/>
    <dbReference type="GeneID" id="27899884"/>
    <dbReference type="eggNOG" id="KOG0768">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_3_0_1"/>
    <dbReference type="OMA" id="IGPRTMW"/>
    <dbReference type="OrthoDB" id="276989at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000018">
        <property type="entry name" value="S-adenosylmethionine mitochondrial carrier protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="9"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="92"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="194"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF09651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="281" mass="30263" checksum="D4DD56D46B4E877A" modified="2013-06-26" version="1">MEGPLRIESPYLRSLIAGGIAGTTVDISLYPLDTLKTRLQSSAGFWASGGFRGVYNGVGSAAVGSAPGAALFFMSYEGTKRYLAPYRQSASSETGVHMAAASLGEIAACSVRVPTEVVKQRAQAKQHPSSLSALKHILGQRATYGLGHVWRELYRGWGITVMREVPFTIIQFPLWEGLKKWSLAQRQGPKPADVTAAESSLYGAMSGAVAAGLTTPLDVLKTRMMLSKERVNAFDMAARIWKQEGGRVFWSGLGPRTMWISIGGAVFLGSYQWASNLLGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDU4</accession>
    <name>N1QDU4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6594 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_49248</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758451.1">
        <property type="nucleotide sequence ID" value="XM_016909103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QDU4"/>
    <dbReference type="STRING" id="692275.N1QDU4"/>
    <dbReference type="GeneID" id="27906240"/>
    <dbReference type="eggNOG" id="ENOG502RIUT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051118_3_2_1"/>
    <dbReference type="OMA" id="MFFETAA"/>
    <dbReference type="OrthoDB" id="5342093at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046529">
        <property type="entry name" value="DUF6594"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502:SF5">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20237">
        <property type="entry name" value="DUF6594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="312"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6594" evidence="3">
        <location>
            <begin position="79"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF10330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="366" mass="41514" checksum="223512C1A73AD277" modified="2013-06-26" version="1">MDEKEVEKDVERHQSPSLPPATASRTNTSWSRTSSTTFAKELPRQDTLRSSTSSSTTCPSRPLERRQTWKPEAEALHGYPMLARFLGTRENYAIYRSFTALNARNLLYHQAKLTHLEHEMHEIEQDLEHEQLHYKVQHLFADDTTCEPGTPGHKLRGKYKELSHALDKYNHLLLQQSKLHRLSHPDGTFVESIWNFINNQATPCPNWLQHPENTAYAIIDGTHTSLQDDLVTLNRAFREQDPFTKFFTSTFLTWWHGIYSRFRAPDGDMGEYVYGDANVSTVMRAFVMVLASALPTCSIVALYFIEDTIRRLAFIVMFSAVFASALTLFTEARSIDVFTASVALASVQVVFVGTAFGSNGDGQARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDZ8</accession>
    <name>N1QDZ8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_119027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758597.1">
        <property type="nucleotide sequence ID" value="XM_016901473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QDZ8"/>
    <dbReference type="GeneID" id="27898610"/>
    <dbReference type="HOGENOM" id="CLU_2172666_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF10476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="110" mass="11509" checksum="2FF4F72C0446A049" modified="2013-06-26" version="1">MDFPDSSTAADGNANGRYPGQPYCQSDQDNDNPTAAAAAAATAGIVSNGDNGSTATATATDTDADLPGQPKDRITIILRYGRGFSQTYKLKPTTDVRKPILSDHLTRFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1QE42</accession>
    <name>N1QE42_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">mRNA transport regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_150645</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease.</text>
    </comment>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758712.1">
        <property type="nucleotide sequence ID" value="XM_016906308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QE42"/>
    <dbReference type="STRING" id="692275.N1QE42"/>
    <dbReference type="GeneID" id="27903445"/>
    <dbReference type="eggNOG" id="KOG2081">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005996_0_0_1"/>
    <dbReference type="OMA" id="LECITSW"/>
    <dbReference type="OrthoDB" id="435593at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000266">
        <property type="entry name" value="mRNA transport regulator MTR10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051345">
        <property type="entry name" value="Importin_beta-like_NTR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057941">
        <property type="entry name" value="TPR_TNPO3_IPO13_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057942">
        <property type="entry name" value="TPR_TNPO3_IPO13_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058537">
        <property type="entry name" value="TPR_TNPO3_IPO13_4th"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363:SF53">
        <property type="entry name" value="MRNA TRANSPORT REGULATOR MTR10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363">
        <property type="entry name" value="TRANSPORTIN 3 AND IMPORTIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24138">
        <property type="entry name" value="TPR_TNPO3_IPO13_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24140">
        <property type="entry name" value="TPR_TNPO3_IPO13_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24139">
        <property type="entry name" value="TPR_TNPO3_IPO13_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="3">
        <location>
            <begin position="32"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF10591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="974" mass="109964" checksum="013CD76122461B65" modified="2013-06-26" version="1">MANMTVNEAFAPVLSALAVMSSGADKTQKTQAHNYLEQFQKSQEAWTHTFSILQSSQSTDEAKLFAATTLKGKIIFDFHQIPRDSWPQLRDTLLGVVAQYAKGPKPIRTQLCVCLANLAILMLDWKDVLQTVVSTLGGDQSGIACVLEFLHVLPEEVTEGRKINLAEEELRERQVELLEMNGPHVLQLLVQYSQSSPEAAKNPQLMECITSWIREVPLSDIVRSPLMGVIMAAIQADSSFDAAVETLCGIFKETREVDENLDTIKVLYPQLASLAPRIAAASEEEDWETFKGVTRVFAEAGEAWCVLVARDPVQFKALVEAVLECCRRDKEREALSQTFNFWYELKQYITLERYMEARVQMVDIYSQLVDIMISHLQYPYGENGNDSDLFDGDREAEDRFREFRHQLGDVLKDCCEVIGVTDCLTKSYLLIEKWVEEFGAQAQNGKVPHWQRLEAPLFSMRAMGRQVPSDENIMLPRLIPLIVQIPDQEKVRFQAVMALGRYTEWTAQHPDTLQDQLNFIMGAFSHPSKEVIRAAALSFKFFCNDCAELLKGYMPQIQQFYEANLDALPSTSQEETTEGVASVLARQPLDSLYPNMKLCCDPIVQRLMTMAQNATEKEQKLAIADLLNLLTIFVQWVTPYVGPADPNPAVQYCQEIFPVLATICETFITFVPIVERVCRCWRYMVLSYRIHSAPLLPGLAERLSQGFATSRQGCFLWATDSIIREFSDESEYVSRQTTDQIYAFYEQQATAFLRALNDLAPEEVPDVIEDFFRLSTDVLLYHPNKIIASDLMGTILRAATTSLTLLKEEPLIATLHFLRDFLAHGGEDAPSPAFNATDGTYNNRPNPPQIQQTVKALIGATGEELTQRCMTGMMYTFPPDCFPDASGVLLALFHLMPRETAEWVGKTVGMLPAGSIAPQEQERLLRNIGQRIDNGETRKIRVLLQDFTNGYRRRNVAPREGLGRLEATKFKFTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>N1QEE0</accession>
    <name>N1QEE0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="13">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SEPMUDRAFT_48762</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 13">ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance. Capable of unwinding D-loops. Plays a role in limiting crossover recombinants during mitotic DNA double-strand break (DSB) repair. Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Interacts with the MHF histone-fold complex to form the FANCM-MHF complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="13"/>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758846.1">
        <property type="nucleotide sequence ID" value="XM_016909081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QEE0"/>
    <dbReference type="STRING" id="692275.N1QEE0"/>
    <dbReference type="GeneID" id="27906218"/>
    <dbReference type="eggNOG" id="KOG0354">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002513_0_2_1"/>
    <dbReference type="OMA" id="EGIKWRN"/>
    <dbReference type="OrthoDB" id="164902at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033677">
        <property type="term" value="F:DNA/RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070336">
        <property type="term" value="F:flap-structured DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033567">
        <property type="term" value="P:DNA replication, Okazaki fragment processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007535">
        <property type="term" value="P:donor selection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060543">
        <property type="term" value="P:negative regulation of strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18033">
        <property type="entry name" value="DEXDc_FANCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12091">
        <property type="entry name" value="FANCM_ID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18801">
        <property type="entry name" value="SF2_C_FANCM_Hef"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000861">
        <property type="entry name" value="Fanconi anemia, complementation group M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1320.20">
        <property type="entry name" value="hef helicase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039686">
        <property type="entry name" value="FANCM/Mph1-like_ID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044749">
        <property type="entry name" value="FANCM_DEXDc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025">
        <property type="entry name" value="FANCONI ANEMIA GROUP M FANCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025:SF20">
        <property type="entry name" value="FANCONI ANEMIA GROUP M PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="186"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="530"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="728"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="731"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="847"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU367027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMF10725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="847" mass="94783" checksum="F346AD5EE9B48834" modified="2013-06-26" version="1" fragment="single">MPNGVAVPTKSLSRNGIDRFFQPAAGRTPIVIEENDDAAFAARLQAEEDELARRHHAKKHVGTGTQALFDATQELADLPEDAFSSSSPEKSPNRNAPIEISSQPAHQQVIRPAGLRGPQTGLKQLTIFGQPATQDLSASQAAHKRHAWPLANRDEKATHHKLDEKAMMTWVYPTNLGSIRDYQFNIVSRSLFHNTLVALPTGLGKTFIAATVMLNYYRWTTHAQIVFMAPTKPLIAQQMEACYGIVGIPKKDTVLMTGETTPAARADQWLEKRVFFMTPQTVINDLKTGICDPKKFVLLVVDEAHKATGGYAYTEVVQFLRRFNSSFRVLALTATPGSTTEAVQAVIDNLGIARVELRTESSLDIRQYTHEKQTDTHVFEFSPEQELVMGLFAKTLRPLLDKVRGQNGYWSNDPLALTPYGLTQARAKWAQSDAGRKAPPAIKGMMNVVFNVLASLAHSIGLLKHHGIGPFYSCVLNFQREVESGQQKGKTAANILQDANFVKMMSTIRTWTNKPEFIGHPKLEYLREIVLNHFLDAGEGRQGSDVPPSATRIMVFASYRDSTEDICRVLKRNEPMIRPHVFVGQAASKGQEGMNQKQQNQIIQDFKGGKYNTLIATSIGEEGLDIGTVDLIVCYDASSSPIRMLQRIGRTGRKRTGKVELLLTKGKEEKDYEKAQDNYAYIQKTIADPSKYDYRDDQSPRILPKEFKPVADKRPVDIPVENSQPVDLNEKHRKGKGKGKIKRPPKKFHMPDNVRTGFVKASKLDSDNIPATFRRVSIPIMPELEPEIAPLPYLEDVLLTREKQQELEERYARTADPEADGLVYAPDIERFPQKLRDLGPTIYTKHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1QEE9</accession>
    <name>N1QEE9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cellular morphogenesis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_150743</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758856.1">
        <property type="nucleotide sequence ID" value="XM_016906369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QEE9"/>
    <dbReference type="STRING" id="692275.N1QEE9"/>
    <dbReference type="GeneID" id="27903506"/>
    <dbReference type="eggNOG" id="ENOG502QQZD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005863_0_0_1"/>
    <dbReference type="OMA" id="NMYTPGC"/>
    <dbReference type="OrthoDB" id="2503993at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902929">
        <property type="term" value="C:plasma membrane of growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024982">
        <property type="entry name" value="Rax2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048266">
        <property type="entry name" value="Rax2-like_second"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048265">
        <property type="entry name" value="Rax2-like_third"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31778">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN RAX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31778:SF2">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN RAX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12768">
        <property type="entry name" value="Rax2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20842">
        <property type="entry name" value="Rax2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20843">
        <property type="entry name" value="Rax2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1171"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="domain" description="Rax2-like second" evidence="3">
        <location>
            <begin position="232"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Rax2-like third" evidence="4">
        <location>
            <begin position="391"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="Rax2-like C-terminal" evidence="2">
        <location>
            <begin position="917"/>
            <end position="1167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF10735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1241" mass="129741" checksum="FC2CFFF68291CCC3" modified="2013-06-26" version="1">MRNILQQLLALGPELTAYIITTPIFLGLPRAQAAVFAQTAVPSPNLDLSQLGRVAVGGDFDSISLYTYQGQNENQSTNGSQSLLTRYPDGAFQSLALADADATIAAMCAFVSTDGTLNGVVVGGNFTSLGGVRADAIALWNPSTNEVTALDGLSGGPVNAVYCDNDTGTVYVGGKFMGGNSTNALAWTNGWVNLPFAGFNGPVNTITKTSNNRIVFGGSFTGLGNMSTPSTPDQQAINVGSGTITASGSSSTSGFSDPNNIICKTGAQQGTGNTWLLADNTGGFWQSSLGFGINPTMLRLYNADYEGRGTKSFYFEEMNGGGVLNLTYVDPVTGQNASCVRFCPLPQGNTTAQDFHFERPIGLSVFRVWITDWYGAGAGLNGIELYSNDIYNYAVNSFNAPSCVDTAAPSDSTALPANAWTQVASKGLTPADFLSTTITDAANVGDATKVVFQPNLPQSGNYSVTLYTPGCILDGTCATRGMVDITASLTSNGSPATTSSYQTNNYDKFEQIYYGYIDTNGFVPTVTLAPAVNQGVPLTVVASRVRFELISTTGGVGGLNGLYEYNPDEAQTSTNYTSSAINRAAISLDAGASFASIAEHNDVLYAAGSFTGKGSANVMSVAGDDATALPRGGLNGEVLDMYLNDTVLYFGGTFNNTAMEPTEGLNNIAAFSIDSNEWSALGAGVNGAVFNILPLTMNITSDNEQPTFAVSGNFTSVNAFGNNAAFESSGFAIWVPSESNWLHNLAGSDSALNGRLTAYSTVPDMQPVYGGMISSQGLDFSDVVELVGSGSPELQSLGIQLSTNRDNSNTSTASVRKRALSDDVSGTNYTGVYDGLFYSESSLNITILGGSFSTMASNGSTIENLIFINDTDSSQSVSGVSGLDSDSIFVAMDTYETMLWAGGAINGTVNGNTATGLVVYDLSANRYAAPHPPALGGENVVVNAITAQPDGTDVYVGGDYSTAGSLPCGPLCYYDTEALQWQSTGSGLSGVVYAMMWSSNTKLIIAGNLTINNNMTTMATYDTKAQTFTAYEGASSLPGPVSAISAVDNAYKELWVSGISSTNQSVFLSKYNDGTWTGASGLGDSTSIRKLQIMPLTSNHASSDLVADDQVLMILGNINIPEQGNASAVLFNGTMYEPYILTSMDNGSQGSLSAIFVQNPQNFMTSKNHGLALGVIVAIGLAIALAITGLVILLGILLERRRRRIEGYVPITADKSANVNRLPPEQLFSKLEGGGQAAPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1QEK7</accession>
    <name>N1QEK7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_110905</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757538.1">
        <property type="nucleotide sequence ID" value="XM_016900882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QEK7"/>
    <dbReference type="STRING" id="692275.N1QEK7"/>
    <dbReference type="GeneID" id="27898019"/>
    <dbReference type="HOGENOM" id="CLU_057738_3_0_1"/>
    <dbReference type="OMA" id="NCQLVIE"/>
    <dbReference type="OrthoDB" id="738517at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
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        </location>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF09417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="322" mass="36104" checksum="B2FC926BFE19B654" modified="2013-06-26" version="1">MTICSVCRDFHLARSFPDAPEDSGCAAHSTTACLNCWQRWISNELKRVQPGELRCFECQAILKESDVKLRATVGTYERYMQLVAFINRPPLQGTYRECLRATCDSGQIQPDDYSTFQCQSCTHKHCVPCQMPFHEGVNCEAPLLERKRAGVRFEVIWKGKMHSMRQAHKSEEDATGEVLDKTCKNCPEPSCGVKIMKAGGCEMMECYKCGLSFCWLCLAPQSNVEDHGSAGHKDDCPLWRRPGIVGPQHVDIDNAEDLLALGLQLDEEEDEEIYGGPDDFLANLQAFHLFRGHRLTQDGDEAEPAARRPPTPEFAALWGSGN</sequence>
</entry>
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    <accession>N1QET5</accession>
    <name>N1QET5_SPHMS</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_117590</name>
    </gene>
    <organism evidence="2 3">
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            <taxon>Dothideomycetidae</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
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    </dbReference>
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            <end position="391"/>
        </location>
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        <location>
            <begin position="317"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="342"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMF11607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="391" mass="44380" checksum="E7F96F19771A5C23" modified="2013-06-26" version="1">MPFDNNTLQGLSAILGCDPIVILRIFQKSDNLLQAARKAVLRVIADTPPAPRSAAQSQTMRGLVTRYLRYFGDKDCVARDLKLFERQGILEPSPWYSRNSQERFDSHCGEPTIIIEGEPWPAWFTQEHFDWLQLMTGIHEGDFYIELKNDENICRAAIKAIMRELPPDVRAEFESDVTSQIGLAVNVPMERISVPTSKPLPPLPQAPRLSSNAAIPVPAVIQSASPGLRDEWTSASECIQFGNQWEQNILDEAEDEAQEPYRPLRVEYLPEMRDDNFTVRNPNAPQIKPFDFERRHLAQNRSFMADDDDDETLQEPPKTSSSRKTGGLSRQNAVRKVGYQPRGNNNSSSTRSRINNGPRRGKYRVVKAVSPRQKLPAWAWGPPQTLRSTRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>N1QEX5</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="2 3">
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016908963.1"/>
    </dbReference>
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    <dbReference type="STRING" id="692275.N1QEX5"/>
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    </dbReference>
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    <dbReference type="OrthoDB" id="102260at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF11677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="104" mass="11935" checksum="BA060D13555EE65A" modified="2013-06-26" version="1">MSNPLYDSHQPRRASSHNVVKQALNWNQWRDSTAQAGAQRSPIVTSDAHGDMLRAARIQAEAEAKRKELLLKRKQEQMDQHMRMGGLHDAHRAALARMQRKVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFG7</accession>
    <name>N1QFG7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-binding domain of Mlu1-box binding protein MBP1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_151327</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016906744.1"/>
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    <dbReference type="GeneID" id="27903881"/>
    <dbReference type="eggNOG" id="ENOG502S0ET">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OMA" id="FKAAFPW"/>
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    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990862">
        <property type="term" value="C:nuclear membrane complex Bqt3-Bqt4"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070197">
        <property type="term" value="P:meiotic attachment of telomere to nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:mitotic telomere tethering at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="APSES transcription factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Bqt4"/>
    </dbReference>
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        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018004">
        <property type="entry name" value="KilA/APSES_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38044">
        <property type="entry name" value="BOUQUET FORMATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38044:SF1">
        <property type="entry name" value="BOUQUET FORMATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01252">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0183">Conidiation</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0749">Sporulation</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="HTH APSES-type" evidence="5">
        <location>
            <begin position="70"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="172"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="225"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="259"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF09218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="406" mass="44788" checksum="14C06BF6814E9D80" modified="2013-06-26" version="1">MAPSIERQHALPEQQNMMLAEERSPPHEILVERRCLGQTELKVKPGQIGTSNATKLENLGVLDYAHLRVPLPKDLTGSGIFLRGTNRKFPEAYFLMRRASDGFISATGMYKAAFPWAQQEEEALEKEYIKSLEEASSEEVAGNVWIDPKKALDLADEYGIRHWIKALLDPEPIIHGTSDPKKTIKSPPPFHMTETTNGAKTPGGGRRTTRGARSMRSESPSKAKATPRKIATPRRPRRTRGTTAEPEEPVVVAPVEPVNGTTASPKTTVNGTTAPPKDTVRLEVETTTGANGEEDVKLKVEMPSNHPNLDIPDNTDEMLEKARQMVAEARKIDGTITREKGKRKIEEVVEKEDEIEAEAASRAAARARPVEVELRKEKIRRRALTGIAATLAVSALIPSIIAAFPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFX0</accession>
    <name>N1QFX0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_149910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760283.1">
        <property type="nucleotide sequence ID" value="XM_016905848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QFX0"/>
    <dbReference type="STRING" id="692275.N1QFX0"/>
    <dbReference type="GeneID" id="27902985"/>
    <dbReference type="HOGENOM" id="CLU_1205409_0_0_1"/>
    <dbReference type="OrthoDB" id="432970at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF12162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="230" mass="26526" checksum="1C4D958036180505" modified="2013-06-26" version="1">MDAHDGNSYVLDLSGFQIGLESPVIPLQEYMEEFGTQIVGIYEHDSAITQLEILLRAGTADPGYGRIYATHHHMYEALNKVVNAGERIKRQSLSELLRSDQRSYVRGMRYHENRIRTALRQLFAIREQQGHPRISAAAHRLKMDSLTRRASLQSSTLEGTAKSAIQRQWDKEGRTMPEEVKQAVEMASPDPWDFQHVAKAVPKLSPPLPRDDKPRRRSWPSRLARMWKRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFY4</accession>
    <name>N1QFY4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DUF803-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_149924</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760303.1">
        <property type="nucleotide sequence ID" value="XM_016905858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QFY4"/>
    <dbReference type="GeneID" id="27902995"/>
    <dbReference type="eggNOG" id="KOG2922">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012349_2_1_1"/>
    <dbReference type="OMA" id="PIRSEAM"/>
    <dbReference type="OrthoDB" id="165382at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF65">
        <property type="entry name" value="MAGNESIUM TRANSPORTER NIPA9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="54"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="463"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="602"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="651"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="74"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="103"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="118"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="516"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="556"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="623"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="667"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF12182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="715" mass="77039" checksum="92CA86FFE427A4DC" modified="2013-06-26" version="1">MYIPTAYGIAQGSADQAQNGGGWSSLIGVVTAICGNVLISFALNTQRYAHMRLSRDRGARVQEKRRNNARRKRRSDEVTEVRNEEHRKQETLGHRALEDRGATETQPLLSKQGSRQLSPSSSPSSPSSSSYSSEELGKDEKDDDDVEEKSYLRSPIWWLGIGMMVVGETGNFLAYGFAPASIVSPLGVVALISNCLIAPLLLKEKFRLRDGLGVLIAVAGAVVVVLSASDSNPKLTPDAIWRLVTTWEFETYLGITVALIIVLTVLSNKYGQKSILIDIGLVGLYGGYTALSTKGIASLLTYSLYKVVTFPISYLLLVVLVVTAVMQIKYVNRALQRFNSTMVIPTQFVMFTISVIVGSAVLYRDFERESPEDAGKFVGGCALTFFGVWCITSGRKSEPNDDYGNEEDDGIGLADEEGTMPEIREHDGPSRNMSLVANSINAPPSLRRAQTAEVGSIPKVHIRAPTLGTTPPGASDWNKYVPEMQPGTASAVHPDPGVLNGNGNDNTNPKKPIMHATTSAPVVPQTPDTSSRPKTPLARTPSGPAERPSPHRTPLNRGQTVASIGSQGLLQRTSSIRLGPLTSPLSGSLAAIVADELRRGVDKTPLGTMKRRPSHRPPPVGRRPTDQNEDNRPLMSSSLKRHSIASTDVEFESQEAADLRTAAGSPPNGSSRVRSLSATISDMFGSSGGGSALKRQRTLERETGRQAAASEEGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>N1QG27</accession>
    <name>N1QG27_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP citrate synthase</fullName>
            <ecNumber evidence="2">2.3.3.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ATP-citrate (pro-S-)-lyase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Citrate cleavage enzyme subunit 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">SEPMUDRAFT_151495</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the formation of cytosolic acetyl-CoA, which is mainly used for the biosynthesis of fatty acids and sterols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>oxaloacetate + acetyl-CoA + ADP + phosphate = citrate + ATP + CoA</text>
            <dbReference type="Rhea" id="RHEA:21160"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.3.3.8"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Composed of two subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.8" evidence="2"/>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757624.1">
        <property type="nucleotide sequence ID" value="XM_016906855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QG27"/>
    <dbReference type="STRING" id="692275.N1QG27"/>
    <dbReference type="GeneID" id="27903992"/>
    <dbReference type="eggNOG" id="KOG1254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006587_4_1_1"/>
    <dbReference type="OMA" id="HMLRYQA"/>
    <dbReference type="OrthoDB" id="3261737at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003878">
        <property type="term" value="F:ATP citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06100">
        <property type="entry name" value="CCL_ACL-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000003">
        <property type="entry name" value="ATP-citrate synthase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.230.10:FF:000005">
        <property type="entry name" value="ATP-citrate synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000024">
        <property type="entry name" value="Probable ATP-citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23118">
        <property type="entry name" value="ATP-CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23118:SF42">
        <property type="entry name" value="ATP-CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="19" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA-binding" evidence="18">
        <location>
            <begin position="44"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00054002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00060724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00062455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00076189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00083544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EMF09503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="665" mass="72394" checksum="08F681C8A0D53B97" modified="2013-06-26" version="1">MATANGTTNGVNGTAPKEALSANDNIQRFVAPSRPLSPTPVHTLFHPKTRCFVYGMQTKAVQGMLDFDFICKRKTPSVAGIIYTFGGQFVSKMYWGTSETLLPVYQSPEAAMAKHADVDTVVNFASSRSVYTSTMELMEYPQIKSIAIIAEGVPERRAREILHVAKKKGVTIIGPATVGGIKPGAFKIGNTGGMMDNIVASKLYRKGSVGYVSKSGGMSNELNNIVAQETDGVYEGVAIGGDRYPGTTFIDHMLRYEADPECKILLLLGEVGGVEEYRVIEAKKAGIIKKPIVAWAIGTVASMLKTEVQFGHAGSMANSQLEQAAQKNKAMREAGFFVPETFEDLPQELSKVYQTLVKEGKIKPAPEPAVPKIPIDYSWAQELGLVRKPAAFISTISDDRGQELLYAGLPITEVFKEDIGIGGVMSLLWFRRRLPKYASKFLEMVLMLTADHGPAVSGAMNTIITTRAGKDLISSLVAGLLTIGSRFGGALDGAAEEFTRAFDKGLSPRDFVDTMRKENKLIPGIGHRVKSRNNPDLRVSLVKEYCQKNFPSTKLLDYAIAVETVTTSKKDNLILNVDGCVAVCFVDLLRNSGAFSAEEAEDYLKMGVLNGLFVLGRSIGLIAHFLDQKRLRTGLYRHPWDDITYLLPELGKGAPGNEGRVEVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1QHC6</accession>
    <name>N1QHC6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SEPMUDRAFT_67157</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 12">Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Vacuole membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ATG22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759955.1">
        <property type="nucleotide sequence ID" value="XM_016909778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QHC6"/>
    <dbReference type="STRING" id="692275.N1QHC6"/>
    <dbReference type="GeneID" id="27906915"/>
    <dbReference type="eggNOG" id="ENOG502QVD3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017518_1_0_1"/>
    <dbReference type="OMA" id="QPWEIFP"/>
    <dbReference type="OrthoDB" id="192733at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032974">
        <property type="term" value="P:amino acid transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17483">
        <property type="entry name" value="MFS_Atg22_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044738">
        <property type="entry name" value="Atg22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050495">
        <property type="entry name" value="ATG22/LtaA_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519:SF3">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 12" id="KW-0072">Autophagy</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <keyword evidence="4 12" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="343"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="513"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMF11834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="583" mass="62961" checksum="287A555FF9321157" modified="2013-06-26" version="1">MDHDDEHGVRAPRYDGEDVSPTSEAELRGWYSTGLAAEIYAVCGVGSFAPVTLEQLAREAGVLRSDGVTPCIQQHENATRFTRIVRSAVESLLITRDEGDVSSQCIIKPFGRTMATSSFALYTFSIAVLVQALVLISFSPVADYGTYRKRLLLSFAFVGAGATMAMVLVWPGIYLVGSLFTIVGVVCLGSTFVLLNSYLPLLASNHSQVRAKSHESLSQAGTHRPVTSPELKLSTQISSRGVGLGYAAAVSTQVLSIGLLVLLKKAHFTSESTPLRVVLLFGGICWFLLTLPGALWLRNRPGPPLRIIEPWKSKLPIALQYARFAWLSVWTTVKIAAKLRQTWIFLIAWFLLSDAIATVSGTAILFARTELHMGTIPIALLSITSIGSGLAGAFAWPIISRRYGLATKQTIIACMILMEIIPFYGLLGFIPFIQSLGFLGLQQIWEIYPLGFVHGFVMGGLSSYCRAFYGEIIPPGSEAAFYALYAITDKGSSAVGPAIVGAIVDGLGTIRPAFGFLAVLIALPIPLVYMIDVGQGRADAVALSKHAGLAAADDQPIRMEDYDHVDEYDTSAGLLRRSSEEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1QHQ1</accession>
    <name>N1QHQ1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mannose-P-dolichol utilization defect 1 protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_145932</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the MPDU1 (TC 2.A.43.3) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764887.1">
        <property type="nucleotide sequence ID" value="XM_016903348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QHQ1"/>
    <dbReference type="STRING" id="692275.N1QHQ1"/>
    <dbReference type="GeneID" id="27900485"/>
    <dbReference type="eggNOG" id="KOG3211">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053568_0_1_1"/>
    <dbReference type="OMA" id="LQVLYYW"/>
    <dbReference type="OrthoDB" id="271506at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000006">
        <property type="entry name" value="mannose-P-dolichol utilization defect 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016817">
        <property type="entry name" value="MannP-dilichol_defect-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 LEC35 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226:SF2">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023381">
        <property type="entry name" value="MannP-dilichol_defect-1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="142"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR023381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF16766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="292" mass="31182" checksum="6698E3288E8498C2" modified="2013-06-26" version="1">MEALETTLRGILTPITRNLPQPISDAATQLLGDSCYRSLVHNITISDTVCLKLAISKALGIAIIGASSIVKIPQLLKLINSQSADGISFLSYLLETVSYLVTLVYNVRNQFPFSTYGETALIAVQNVAISVLVLQYSGKAPAAAVFVGGLAAAGYALYNESVVSMAQLQYFQAGAGLLGVASKLPQIVTIFSQGGTGQLSAFAIFNYLAGSLARIFTTLQEVDDKLILYGFLAGFSLNLVLALQMIYYWNSPSTKHQEKLTPTKAGAPSYANVVKASGSQRQKNSPSTRRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-12-14" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>N1QI25</accession>
    <name>N1QI25_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_119333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758934.1">
        <property type="nucleotide sequence ID" value="XM_016901501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QI25"/>
    <dbReference type="GeneID" id="27898638"/>
    <dbReference type="HOGENOM" id="CLU_1054372_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF10813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="264" mass="29457" checksum="EE92253E47CE9B06" modified="2013-06-26" version="1">MTSHGSDVLHQIGSAPGQQYGDSSVVALRMLGCPTPTVQVDRCSCRPLDTTYSVVMTPSQLWMSQNCQRDQLPPQPQMPHWSMYEPVREREQFLTESLSLTPQYTFAGRQQRPAYLEGQQLRSSSFATHEVPATPRSSTQHGDGTAISEYLAVAGSQVHDPSLPRYGGNQLDAYMFLLDDLNSDPPFHATYMGGSTEITQQLPQQQTDPSNILNMQPRAQLLQRRLQSHDDHGVQARSFAIHHFHRNALSATTHILPTVIYNGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1QIJ3</accession>
    <name>N1QIJ3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_146122</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765126.1">
        <property type="nucleotide sequence ID" value="XM_016903464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QIJ3"/>
    <dbReference type="STRING" id="692275.N1QIJ3"/>
    <dbReference type="GeneID" id="27900601"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046889_1_1_1"/>
    <dbReference type="OMA" id="QEQVTVC"/>
    <dbReference type="OrthoDB" id="3214149at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000201">
        <property type="entry name" value="C2H2 finger domain protein (Gli3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043359">
        <property type="entry name" value="GLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718:SF4">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="172"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="195"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="379"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="292"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="223"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="452"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF17005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="466" mass="51771" checksum="3A721DEE298D0BE9" modified="2013-06-26" version="1">MADSPASSDLSDPPSVDSDAEDRLSTPAPPSSRPSVDIAHNEADQPPSKRRKTAQSSLATFEAATPHPEEDDESFSVSSDGYSSAPGSPNDDEWSIREQAQTQCLWRDCAFGTAENNDDLVKHVQSTHCATGGPKKTKYVCEWGECQRKTSNHPSGYALKAHMRSHTKEKPYYCQLPECDKAFTRSDALAKHMRTVHEPEPVRGTDSAVPVTGKGKALKVKSNGGTKSALVQDTGPTHDEDGNWVNPSPPNDNITYIPAHHPITGQPGFMIHYPPDIHFTAWESSITADQLMRLLRRQVHWAQKEAEELKKQVEALEQQKREEWQLKEILLEGTLEAELAHADQDQMMSNVDLRVKEAMAQDVEPSKLLKWTKGEPKWRTRPNILQHVENEPDTDAPKKDRGSNSPSPPPTAASGGFDGEADPFDNYLAAQMSRYEERERMRSAQSTPAKLQQQQQQQQQQGVGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1QIK4</accession>
    <name>N1QIK4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_14184</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765182.1">
        <property type="nucleotide sequence ID" value="XM_016902980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QIK4"/>
    <dbReference type="STRING" id="692275.N1QIK4"/>
    <dbReference type="GeneID" id="27900117"/>
    <dbReference type="eggNOG" id="ENOG502QQZ5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_782007_0_0_1"/>
    <dbReference type="OMA" id="WFYLEEK"/>
    <dbReference type="OrthoDB" id="342264at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036930">
        <property type="entry name" value="WGR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008893">
        <property type="entry name" value="WGR_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142921">
        <property type="entry name" value="WGR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51977">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="WGR" evidence="3">
        <location>
            <begin position="195"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="127"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF17061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="332" mass="37058" checksum="CCD5735557030645" modified="2013-06-26" version="1" fragment="single">MVHKALSGCVIVTAGTGEKDWNNKQLKDWIDNASGTFERTITDETTHLVVTENLWAAAGPLVEDVIARKKNGQNIKVVSQKWLEDSLLAKSKLKEKPHEFAVPGSADREGGPGDIRSHTGLIKELYLENTELSAAQEKMNLKQQQMENDLAKEQLAESERELSKHIKASMSVPEQAAIFKKGAQKARALLASKRNHHIYQDPTGFHFDTTLTKVDTKNNTNERYNLTIFESNATPHTYAFTTSFSGTRVPQVINTIVGIGSNLPTAFRAFRNAFKEKTGIEWNDRIKVAREREQALKAAKKLGMAVAGPQTTEDFRSQKFQYYPPAYGPIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1QIP2</accession>
    <name>N1QIP2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Multifunctional tryptophan biosynthesis protein</fullName>
            <ecNumber evidence="8">4.1.1.48</ecNumber>
            <ecNumber evidence="7">4.1.3.27</ecNumber>
            <ecNumber evidence="9">5.3.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">SEPMUDRAFT_146164</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21540"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="EC" id="5.3.1.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21732"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="4.1.3.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.48" evidence="8"/>
    <dbReference type="EC" id="4.1.3.27" evidence="7"/>
    <dbReference type="EC" id="5.3.1.24" evidence="9"/>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765181.1">
        <property type="nucleotide sequence ID" value="XM_016903490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QIP2"/>
    <dbReference type="STRING" id="692275.N1QIP2"/>
    <dbReference type="GeneID" id="27900627"/>
    <dbReference type="eggNOG" id="KOG0026">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4201">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007713_2_0_1"/>
    <dbReference type="OMA" id="EPIEWAN"/>
    <dbReference type="OrthoDB" id="524799at2759"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00405">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000136">
        <property type="entry name" value="Multifunctional tryptophan biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00135">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045186">
        <property type="entry name" value="Indole-3-glycerol_P_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001468">
        <property type="entry name" value="Indole-3-GlycerolPSynthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001240">
        <property type="entry name" value="PRAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854:SF2">
        <property type="entry name" value="INDOLE-3-GLYCEROL-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854">
        <property type="entry name" value="TRYPTOPHAN BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00697">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00614">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="15" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="14" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="16" id="KW-0413">Isomerase</keyword>
    <keyword evidence="17" id="KW-0456">Lyase</keyword>
    <keyword evidence="18" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="21">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Indole-3-glycerol phosphate synthase" evidence="22">
        <location>
            <begin position="153"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="N-(5'phosphoribosyl) anthranilate isomerase (PRAI)" evidence="23">
        <location>
            <begin position="498"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00012572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00018819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF00697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="EMF17060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="669" mass="72241" checksum="0599DC1B53112FBC" modified="2013-06-26" version="1">MGEQCIYSVFGGTVEKTGEILHGKTSPLRHDGKGVYSGLPQDVAVTRYHSLAGTHPTLPESLEVSSWIAVGPDGGKGVIMGVRHKEYLVEGVQFHPESILTAGGRLMLKNFLLMQGGTWTENARLQAEAQNTANGSKSQLNGTTNGGNKENILHRIYDQRKIDVAEQRQLPSHRMEDLQAAYELGLAPPSISFPDRLRQSPFKLALMAEIKRASPSKGIIQIDARAPEQARLYALAGASTISVLTEPHWFKGSIDDLCNVRKAVDGMSNRPALLRKEFVFDEYQILEARLAGADTVLLIVKMLHLELLTRLYKYSQSLGMEPLVEVNTLEEMEIAVKLGSQVIGVNNRNLTSFEVDMDTTTRLVKIVPKTTILCALSGIAGPKDVEPYQQNGVGAVLVGEALMRAADTTKFISELLGSSEGSIKTNSQKKLLVKICGTRTPEAAKTAIEAGADLIGVIMVTGRKRCVSADTARKISEIVHTTRKSTPSVTVVASNEANATATSFFAHASSHHVQHPDRALLVGVFLDQPLDFILEQHRLINFDIIQLHGSEPLEWAQLIPVPVLHKFNPGDAGLTTRGYHSLPLLDAGAGNGKQLDMARVKSLLESDGGLQVVLAGGLNCDNVSEALAALGDARSQVAAVDVSSGVEEDGEQDLSKIRAFVKAAKEIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2023-02-22" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>N1QIZ4</accession>
    <name>N1QIZ4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_146279</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765297.1">
        <property type="nucleotide sequence ID" value="XM_016903548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QIZ4"/>
    <dbReference type="GeneID" id="27900685"/>
    <dbReference type="HOGENOM" id="CLU_2544052_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF17176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="83" mass="9241" checksum="54163AD8BDEAF22A" modified="2013-06-26" version="1">MMTNSHWLSTACLCTCRALKNTTLKILINQVQNLNIDASVDITSSSTNLITRSNQHGHLCPFDRTAVACQNTGLSLHRLERDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2023-02-22" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJ11</accession>
    <name>N1QJ11_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_149671</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759916.1">
        <property type="nucleotide sequence ID" value="XM_016905700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJ11"/>
    <dbReference type="GeneID" id="27902837"/>
    <dbReference type="HOGENOM" id="CLU_2528896_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF11795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="84" mass="9865" checksum="E6E82A920CFD8B56" modified="2013-06-26" version="1">MYMPWESGRAVEEWAWFLRKFRRYGYRKSKLKTTVHVLSRMHSLRDVLSLAGKLDAFGAEQAQKAKAFFKDMGIKARTNFTFIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJI0</accession>
    <name>N1QJI0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Solute carrier family 40 member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_146402</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in iron transport and iron homeostasis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765481.1">
        <property type="nucleotide sequence ID" value="XM_016903631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJI0"/>
    <dbReference type="STRING" id="692275.N1QJI0"/>
    <dbReference type="GeneID" id="27900768"/>
    <dbReference type="eggNOG" id="KOG2601">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020370_5_0_1"/>
    <dbReference type="OMA" id="VAMGHVM"/>
    <dbReference type="OrthoDB" id="648861at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005381">
        <property type="term" value="F:iron ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17480">
        <property type="entry name" value="MFS_SLC40A1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009716">
        <property type="entry name" value="Ferroportin-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11660">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 40 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11660:SF57">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 40 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06963">
        <property type="entry name" value="FPN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF17360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="525" mass="58073" checksum="2C42010228E484AB" modified="2013-06-26" version="1">MDSSIQDETSEHRLLGENEIRTADEFTVDGQPSATPLGHITTLLYTSHALSTWNSRVFEFGSFLFLAALFPSTLLPASIYALARSASAAALSPFLGSYIDHVDRLRVVRVSIVSQRLAVALSCAGLFLLEESEDLRTSKWSFVGLAMLSMLACIEKLGSVLNTISIERDWVIIVAHNHEETLRRELMCTNWTAHCLISVCVGMNSQMRRIDLFCKLLGPLAIAFLDEYSSRTAIVATGVLTLASLPVEYYSIFHVYSNVASLRHPRTLPARRSGRIGVYAMITSYMAKTKTYFRHPASLPSIALALLHFTVLSFSGQMITYLVALGTPSGMVGVLRAASAVFELATTWFAPIIMSRIGPIRAGIWFLNWEIACLMAAVLVLWSDLGPVATAAGLVSAVVVSRIGLWGYDLSAQTIVQEEVEEENRGTFSSQEFSLQNIFELLAFATTIVFPRPSQFKFPATISAAAVALAGILYALFVRSRRGHLVHLCRCIDRHEMRKRYQHWLQIPLQEDVSMHGGRRRSGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJQ8</accession>
    <name>N1QJQ8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Choline-sulfatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_34896</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765592.1">
        <property type="nucleotide sequence ID" value="XM_016908584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJQ8"/>
    <dbReference type="STRING" id="692275.N1QJQ8"/>
    <dbReference type="GeneID" id="27905721"/>
    <dbReference type="eggNOG" id="KOG3867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006332_9_1_1"/>
    <dbReference type="OMA" id="RAYFGAC"/>
    <dbReference type="OrthoDB" id="96314at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16032">
        <property type="entry name" value="choline-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000032">
        <property type="entry name" value="Choline sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017785">
        <property type="entry name" value="Choline-sulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025863">
        <property type="entry name" value="Choline_sulf_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03417">
        <property type="entry name" value="chol_sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45953">
        <property type="entry name" value="IDURONATE 2-SULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45953:SF1">
        <property type="entry name" value="IDURONATE 2-SULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12411">
        <property type="entry name" value="Choline_sulf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase N-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Choline sulfatase enzyme C-terminal" evidence="5">
        <location>
            <begin position="441"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF17471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="524" mass="59508" checksum="4597AA843D7FBC70" modified="2013-06-26" version="1">MADQLAAPQLKMYNEKSQIKTPHLDQLAAKSVVFDSAYCNSPLCAPSRMAMITGQLPSKIGAYDNASPISEDTPTYAHYLRNAGYECVLGGKMHFIGDQLHGYEYRLTADIYPADLGWSVNWDEPDTRLEWYHNSSSILQAGPCIRSNQLDYDEEVMFKAKQYLYDHVRKPQNKRPFCLTVSLTHPHDPYTIEHKYWDMYKDVDIAMPDVEIPKDQLDPHSKRLQHVCDLEDYDFTPEQIKNARRAYYGAVSYVDHNIGILMQTLKDCKLDDNTIVIFSGDHGDMLGERGLWYKMSYFESSVRVPMLFSYPKQWAPHRVPQNVSTLDILPTLVDIVGSKLVPGLPMDGVSIVPHLKGKSTHDTVFAEYMGEGTIAPMMMIRRGAWKYITCPADPDQLYNLAEDPKELTNLATSSDAATKKMYNAFVAEAKAKWNMEAITADVITRQRQRRFCFSALKQGKWTSWDYSVPDNSQDKYIRSHMDLDDLERRARYPIVDAHGNVKTFDTSGKDGALAIPHQAGAAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>N1QK54</accession>
    <name>N1QK54_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TeaA receptor TeaR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_146564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765701.1">
        <property type="nucleotide sequence ID" value="XM_016903733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QK54"/>
    <dbReference type="STRING" id="692275.N1QK54"/>
    <dbReference type="GeneID" id="27900870"/>
    <dbReference type="eggNOG" id="ENOG502S2RX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023414_1_0_1"/>
    <dbReference type="OMA" id="PINRPEG"/>
    <dbReference type="OrthoDB" id="10249311at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="515"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF17580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="569" mass="62190" checksum="2CB5F84B09E51EDC" modified="2013-06-26" version="1">MAATVNGAWTYSVPLEQTDGNARAYNPRGSPRADHEWDENGSKALERRSSTWDLLSDSETTKQRRTSVRASNSTAVKKRSRDALRENKRLPQSAATTSKGTAGSAYPEEDNSLWVHRDKLAQIEIQEMEEAGIYLRPSRRSQSLGPGRESGRTSRSVSRSGSRKAAHGPLNGVGYDEEYTAAYPSRNDMNMDHPLASPHEDMRPQWSPQRAEPYFDSGRDPERQPNNQASTELPSSTKPFSQTSTQQQQHMARPGTSRIPVSRISPVPVPHDVVERDSPLPRSRAGSQSVSSSWDELQYARKARSASISSQVLLESDPDGKRRSPPGSSNKHSSGEGSPQKARAPKQTPTGRKSSIPSSSAARPGSSAGKRAPSAAAIRRPGSSSGHKSRPSTGRFSPDGEAPWIATMYKPDPRLPPDQQMIPTHAKRMMQEQWEKEGKTGTVYDRDFNLLNDEDLSRKAPVLTLQSQNLDVPANLPSPTKSLSPNSYSTEHGWPLRSKSENGSVRPGTSGGYKITPTIPSTPTIQRSAAPSPMPSQPMSPGHDGTLRVPELSEKEEFAPKKGCCCVMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKY7</accession>
    <name>N1QKY7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Serine/threonine-protein kinase SSN3</fullName>
            <ecNumber evidence="4">2.7.11.22</ecNumber>
            <ecNumber evidence="3">2.7.11.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Cyclin-dependent kinase 8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Serine/threonine-protein kinase ssn3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">SEPMUDRAFT_130583</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="4"/>
    <dbReference type="EC" id="2.7.11.23" evidence="3"/>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016766052.1">
        <property type="nucleotide sequence ID" value="XM_016902363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QKY7"/>
    <dbReference type="STRING" id="692275.N1QKY7"/>
    <dbReference type="GeneID" id="27899500"/>
    <dbReference type="eggNOG" id="KOG0666">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_181_6_1"/>
    <dbReference type="OMA" id="YFKNGGP"/>
    <dbReference type="OrthoDB" id="6284126at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990508">
        <property type="term" value="C:CKM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060258">
        <property type="term" value="P:negative regulation of filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070481">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, non-stop decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031648">
        <property type="term" value="P:protein destabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07842">
        <property type="entry name" value="STKc_CDK8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000408">
        <property type="entry name" value="Serine/threonine-protein kinase SSN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF495">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 25" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="15" id="KW-0804">Transcription</keyword>
    <keyword evidence="13" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="24">
        <location>
            <begin position="73"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="481"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="23">
        <location>
            <begin position="9"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="489"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="504"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00039418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00040708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00041823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="EMF17931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="538" mass="58801" checksum="B09C7E9BE3495D3C" modified="2013-06-26" version="1">MTSTNNNPPSVPPPGPAAPAPLLPSAPPSVGPIPPTHSLKRGAPAAVDEADAPSLVRMNATPYAPQRHINDNYDIVGFISSGTYGRVYKAVNKRGVHQANPAKHPDGRPIEAFAIKKFKPDKEGELQYTGISQSAIREMALCTELSHPALIHLVEIILEAKCIFMVFEYAEHDLLQIIHHHSLLPRTPIPASTLRSCMYQIFSGLLYLHQNWVIHRDLKPANIMVTSGGAIKIGDLGLARLFWKPLHALFSGDKVVVTIWYRAPELLLGSRHYTPAIDLWAVGCIFAELLSLRPIFKGEEAKQDSKKAVPFQRNQMGKIGEILGLPRKNEWPLLASMPEYPNLSSVSMHNPAVNRPMGLEKWYRNTLQNNHYGRNAPDDSALDLLKSLLRYDPLKRMTAEQALQHPYFTAGIGTGGGGGGYSSFSPSTTTTATTSSSSAAATAAAGATAKIQALYSNCFEGLENKYPPRKVSTEAHNEIGTTTTAATTNHNSAVTGSKRSAAIQQQAQQAQQQQQQQQQQQQQDERLLGPVQKKMRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>N1QL10</accession>
    <name>N1QL10_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_146091</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765098.1">
        <property type="nucleotide sequence ID" value="XM_016903450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QL10"/>
    <dbReference type="STRING" id="692275.N1QL10"/>
    <dbReference type="GeneID" id="27900587"/>
    <dbReference type="eggNOG" id="ENOG502RXSB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016574_3_1_1"/>
    <dbReference type="OMA" id="KAWYYLR"/>
    <dbReference type="OrthoDB" id="4132249at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF20">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="42"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF16977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="614" mass="67936" checksum="1A432E06A2746E90" modified="2013-06-26" version="1">MLIAALNGPVEVTVASRGFKHAGDMSEPSALVSAAPATAKRACDACHRRKVKCIGDGTRPCKNCTSAGLTCTYNAIPQKKGPKGSRAKVISELRETQRQSQLAAKRHGLEFDSPPHSPTHLRKTGLLSMKMITTCVDYYFANMYPTQPIIHRQKVGETIGQMETSGEAYCLVVSLCAYMMIQPNMVLPPEAFEGLDFAPQPSLQLGQALLQEALRVRRRHNYIENPTVWSVITSFFFFGSYFCLDRHNTAWFHLREATTLAQIIGMHDEATYQATDIVESSRRRRLYWLLFVTERAYALQQHKPLTLHATINLPTLDEDPAETVELNGFIHLVNLFRPFDDTFVGLWNKARVGCTTEWLARLQQQLSDALPAYLQCTESQAVDLRCSQQWLRTMVWQLSISHGFLSSAAPDNAMSFKYPIEISRDLVHSATQFTQQSMEVHGIGLIEKLFDVACTLTDVMSVIPHEHYTFGFGPRDYLNQLMTLISTLRGGQQRYMPLLMQKISDSMPNVPGYTVPTAMPPRLRSEEFYDHSHSSAGNSHDSSPFGSPLSAGAAQPFAGIGHYPAEIHQYGGLPVSGAQAIPSHGGSGLFDVSAVYGPAAAGGQALHGKVIDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2024-01-24" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1QLB2</accession>
    <name>N1QLB2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_117942</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760112.1">
        <property type="nucleotide sequence ID" value="XM_016901387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QLB2"/>
    <dbReference type="GeneID" id="27898524"/>
    <dbReference type="HOGENOM" id="CLU_1741725_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046670">
        <property type="entry name" value="DUF6540"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20174">
        <property type="entry name" value="DUF6540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF11991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="150" mass="17198" checksum="0B738082BFD915A9" modified="2013-06-26" version="1">MPKFYEVSAAEVQGTRYLGTLLCVATEPNQRPGRCFHLKEGSSRVMEFESKSYAVPKWSLRTLNCVLMGTVRISEMARFKKVCQSVKAPDGQPQDGRMWEQWLENVNNALEGEWCGYQWRTASHQHQRLSGRALPTESVMIMSGMERMSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1QLE9</accession>
    <name>N1QLE9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-terminal nucleophile aminohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_149832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760167.1">
        <property type="nucleotide sequence ID" value="XM_016905797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QLE9"/>
    <dbReference type="STRING" id="692275.N1QLE9"/>
    <dbReference type="GeneID" id="27902934"/>
    <dbReference type="eggNOG" id="KOG1268">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042555_1_1_1"/>
    <dbReference type="OMA" id="CSEHYLP"/>
    <dbReference type="OrthoDB" id="444432at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061672">
        <property type="term" value="C:glutathione hydrolase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008242">
        <property type="term" value="F:omega peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01908">
        <property type="entry name" value="YafJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052373">
        <property type="entry name" value="Gamma-glu_amide_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43187">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE DUG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43187:SF1">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE DUG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="1">
        <location>
            <begin position="2"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF12046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="351" mass="38675" checksum="3B704A214CE86F7B" modified="2013-06-26" version="1">MCRWFAYISSTEPCLLEDVLVSPQHSLVKQVSDHYLPKLVPHKGDQPAEDDAKARNIVFNFDGLGIAWYTSSNADFELADTGESADGTQKDGLRPALYKTIQPPRNDGNFLSICANTETRVLFGHIRASSGTAIATTNNHPFVFGRHTFMHNGAASDFQQIKRAVIHEMSEAAYARVYGGTDSEHIAGLYMTYLTSSGDASTFENIYSPQEMTAALHKAVATIIGLQHKILGSAKRANSLNLCATDGVHLIAYRFRNHKTSQPPSLYYSTKAGVTLNRKYPDNADGVARPQRYVGIPEERHGDHLIVASEPSTYKENDWELIGRNQYLVSGPSGIFEVQDCPYGAGWDGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1QLZ5</accession>
    <name>N1QLZ5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flavo protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_145584</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HFCD (homooligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764415.1">
        <property type="nucleotide sequence ID" value="XM_016903143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QLZ5"/>
    <dbReference type="STRING" id="692275.N1QLZ5"/>
    <dbReference type="GeneID" id="27900280"/>
    <dbReference type="eggNOG" id="KOG0672">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019412_0_0_1"/>
    <dbReference type="OMA" id="HVHVLDF"/>
    <dbReference type="OrthoDB" id="70387at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071513">
        <property type="term" value="C:phosphopantothenoylcysteine decarboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="entry name" value="Flavin prenyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359:SF21">
        <property type="entry name" value="FLAVOPROTEIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359">
        <property type="entry name" value="HOMO-OLIGOMERIC FLAVIN CONTAINING CYS DECARBOXYLASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="Homo-oligomeric flavin-containing Cys decarboxylases, HFCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140860">
        <property type="entry name" value="Pseudo ankyrin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="2">
        <location>
            <begin position="96"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF16294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="581" mass="65322" checksum="23A3EC8D8E3EE819" modified="2013-06-26" version="1">MADDHDADNDDALRLSAPALHHSRTLNVVFASLGCDDRRIVEDLLPTLASLPDVSLRAILDPAFCGQAFVNASTSCLTMPNIMRRAPTPNALAVELEAAELCEWADLLVLAPMDAHNLAKMLHGHTDNLVLELIRSWDVSKKILLLPGMSSRMWENPMTKKQLTKIRRKWNWVQVLQPMLWAFVSEQKKLVSWEAAEELVDAVRNQVDLINIGAGLDVSPDHPTSFPTPSKKTGILPPELWTMIMDFTGDWELAQKLHIFTNLRPTADWTSHTSPQGPRNYMETLELTLLRGNLSDVKHFIATHSVPRWLSKLCIKLIMRFAMTDLLAHLEASHKDLFWATFGQTFLPDKASSVFGRTEILEYWRTSPSFLNKEYNSEALDGASRAGFVNVLEWWQHSGLPLKFTEAALEQASGQGHISVLEWWKAQSTAVGDSSVSVDSSKVRLKPGKSICYATQNGHTDAVHWWLRSGIAFPHEDTVAKLASTHGHVDILQIWYELKGSKMIFDNQVLVGATKSGNVAVLEWWKQSGLKVEYKTCDVEEALEDGYEGEREVQVRRWWAQNGLNLGVGTSEWMKTKVLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1QM35</accession>
    <name>N1QM35_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Cutinase</fullName>
            <ecNumber evidence="3 12">3.1.1.74</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SEPMUDRAFT_146374</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the hydrolysis of complex carboxylic polyesters found in the cell wall of plants. Degrades cutin, a macromolecule that forms the structure of the plant cuticle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>cutin + H2O = cutin monomers.</text>
            <dbReference type="EC" id="3.1.1.74"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the cutinase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.74" evidence="3 12"/>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765438.1">
        <property type="nucleotide sequence ID" value="XM_016903611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QM35"/>
    <dbReference type="STRING" id="692275.N1QM35"/>
    <dbReference type="GeneID" id="27900748"/>
    <dbReference type="eggNOG" id="ENOG502S47Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040058_1_0_1"/>
    <dbReference type="OMA" id="ICHAGDG"/>
    <dbReference type="OrthoDB" id="2975078at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050525">
        <property type="term" value="F:cutinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043580">
        <property type="entry name" value="CUTINASE_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011150">
        <property type="entry name" value="Cutinase_monf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250:SF2">
        <property type="entry name" value="CUTINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250">
        <property type="entry name" value="CUTINASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00129">
        <property type="entry name" value="CUTINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00155">
        <property type="entry name" value="CUTINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 12" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005141856" description="Cutinase" evidence="12">
        <location>
            <begin position="19"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="70"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="126"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="126"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="312"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="161"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="293"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR611150-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR611150-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMF17317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="332" mass="31503" checksum="69C3749967594661" modified="2013-06-26" version="1">MQFLSLFTIAACTLRAATAPVNVEKRQLAGSGPLSSLSSLGIPSFSNPLSSLGGGGGGASSGISGLQGLSSGLGSGLTPTEGTKRQTTGSSPSLTGGSSSGIGNWGLPSSGLSGLGSLGSGISIPKGSGSSSLGGLQSSTGTSTTGTPDTGASGNASSDGCRALTLLFARGTGELGTMGTVVGPPLAKALANALGEDKVTATGVEYAADAGGNANLGASGGPAMASQAKAALSSCPDTKLILGGYSQGAMVVHNALSAQGLDASKVAAVVAFGDPLRSQAFAGVDASKVKNFCGSADFLCSAGGGTTSSGSHLDYSGDAEAAAKFIVGVVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>N1QM52</accession>
    <name>N1QM52_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SEPMUDRAFT_57661</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765468.1">
        <property type="nucleotide sequence ID" value="XM_016909444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QM52"/>
    <dbReference type="STRING" id="692275.N1QM52"/>
    <dbReference type="GeneID" id="27906581"/>
    <dbReference type="eggNOG" id="KOG0578">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_26_6_1"/>
    <dbReference type="OMA" id="MVDIMKF"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019236">
        <property type="term" value="P:response to pheromone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01093">
        <property type="entry name" value="CRIB_PAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06614">
        <property type="entry name" value="STKc_PAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000011">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000385">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033923">
        <property type="entry name" value="PAK_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0589">Pheromone response</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CRIB" evidence="16">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="378"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="108"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="263"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="298"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMF17347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="657" mass="72857" checksum="4D9A113214E62372" modified="2013-06-26" version="1">MDGLTSPNGINSRQRYSDETKESKVLKKKSGFSSLMSSLVGAPRKPTISAPENPVHVTHVGYDQETGEFTGLPKEWQRTLQANGITEQEQKKNPQAIIDVVTFFNENNDNGSDDWTYHKFDHAKPSESPQGYQSALSPGGYVLSPPASPRFPKNEGESFENPRAPPPVPRGSSQGYGMSSPISPQMNGNMLPLRPAPRPPGSQSSNMIPQRPAPPVPGSQRDQPRTEDGLPAVRYAPPTVTDISSNTQPMQNRSRANTGPTYQSQQQQQSPISSPHQYQQQQEQAMKAAQQALKQASLERSQSQRHPSNNASHHEQQQQQQIAPASSDTRQVPHPAAVDPRVGPAPRPRQRPRQSITNAEVLNKLQHICNAADPTKKYRNLIKIGQGASGGVYTAFEVGTNKCVAIKQMNLEQQPKKDLIINEILVMKDSKHKNVVNFMDSFLVKGDLWVVMEYMEGGSLTDVVTFNMMSEGQISAVCRETLHGLQFLHSKGVIHRDIKSDNILLSLEGSIKLTDFGFCAQINESHMKRTTMVGTPYWMAPEVVTRKEYGRKIDIWSLGIMAIEMIEGEPPYLTESPLRALYLIATNGTPTIKEEHNLTPVFRDFLQFALKVDPEKRASAHDLLKHAFIQTAEPLATLAPLVKAARLARAEERKNKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1QMR5</accession>
    <name>N1QMR5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mob1_phocein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_146372</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765434.1">
        <property type="nucleotide sequence ID" value="XM_016903609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QMR5"/>
    <dbReference type="STRING" id="692275.N1QMR5"/>
    <dbReference type="GeneID" id="27900746"/>
    <dbReference type="eggNOG" id="KOG0440">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038321_3_2_1"/>
    <dbReference type="OMA" id="VDNEQMF"/>
    <dbReference type="OrthoDB" id="8170117at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035974">
        <property type="term" value="C:meiotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071958">
        <property type="term" value="C:new mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071957">
        <property type="term" value="C:old mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902554">
        <property type="term" value="C:serine/threonine protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034973">
        <property type="term" value="C:Sid2-Mob1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903473">
        <property type="term" value="P:positive regulation of mitotic actomyosin contractile ring contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031031">
        <property type="term" value="P:positive regulation of septation initiation signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007096">
        <property type="term" value="P:regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF17313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="227" mass="25858" checksum="78B6ECE187E1F04C" modified="2013-06-26" version="1">MTSFINTINSNARSGRGTAFQPQTRKKGTNSWQLKQFAEATLGSGSLRKVVQLPEGEDRDEWLAVNVVDFYNQINLLYGAITEFCSPQSCPEMKATDEFEYLWHDPPAFPKPTRLPAPTYISHLLAWTSNHLSNSTVFPTHPGVPFPSNFQQTIRTIFKRLYRIYAHIYCHHYAVIRGLGLEAHLNTGFKHYVLFVEEFGLADEKGNKKGEWYGPLGELVESMLRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>N1QMW2</accession>
    <name>N1QMW2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_122333</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765015.1">
        <property type="nucleotide sequence ID" value="XM_016901762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QMW2"/>
    <dbReference type="STRING" id="692275.N1QMW2"/>
    <dbReference type="GeneID" id="27898899"/>
    <dbReference type="eggNOG" id="KOG0329">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_1_0_1"/>
    <dbReference type="OMA" id="EHETTQE"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000346">
        <property type="term" value="C:transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="145"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF16894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="337" mass="39009" checksum="305CFB9DCD364DC1" modified="2013-06-26" version="1">MCHTRELAFQIKNEYQRFSKYMPEVKTEVFYGGTDIKENEKLLSNKATHPHIIVATPGRLNALVREKKLRLGSVSRFVLDECDKMLDQIDMRRDVQEIFRATPPQKQVMMFSATLSNQTKPVCKKFMQNPLEIYVDDEAKLTLHGLQQYYVKLTEEEKNRRLNDLLDKLRYNQVIIFVKNTLRASELDRLLRECNFPSITVHSNMPQEERIKRYTAFKNFDKRICVSTDVFGRGIDIERINLAINYDMPDSTSNKEAERQKTVGADKGSAEFKESVAQAADTYLHRVGRAGRFGTKGIAISFVSSDRDMEVLKAIEARFEKKVDEYPEEGVQLQDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>N1QP11</accession>
    <name>N1QP11_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_146854</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016766080.1">
        <property type="nucleotide sequence ID" value="XM_016903910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QP11"/>
    <dbReference type="GeneID" id="27901047"/>
    <dbReference type="HOGENOM" id="CLU_2147444_0_0_1"/>
    <dbReference type="OrthoDB" id="3635514at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF17959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="112" mass="12369" checksum="D8A0EF3CC3208885" modified="2013-06-26" version="1">MCLLTRLCLSRGYAPSLGVSIILRSGTKSTASWVPASTSSHPILTLMLWRGPSVLLKLTEMPWYWKAEQYMAQSLPGLPATPPILSSPAKVVDLLPQADRSRQKQAKPRGFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M3ASE8</accession>
    <name>M3ASE8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Survival Motor Neuron Gemin2-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_136584</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMN family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756535.1">
        <property type="nucleotide sequence ID" value="XM_016902785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3ASE8"/>
    <dbReference type="STRING" id="692275.M3ASE8"/>
    <dbReference type="GeneID" id="27899922"/>
    <dbReference type="eggNOG" id="KOG4327">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093937_1_0_1"/>
    <dbReference type="OMA" id="MMSWYFA"/>
    <dbReference type="OrthoDB" id="197400at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22852">
        <property type="entry name" value="SMN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22851">
        <property type="entry name" value="SMN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040424">
        <property type="entry name" value="Smn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047313">
        <property type="entry name" value="SMN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049481">
        <property type="entry name" value="SMN_G2-BD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39267:SF1">
        <property type="entry name" value="SURVIVAL MOTOR NEURON PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39267">
        <property type="entry name" value="SURVIVAL MOTOR NEURON-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20636">
        <property type="entry name" value="SMN_G2-BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Survival Motor Neuron Gemin2-binding" evidence="7">
        <location>
            <begin position="9"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="66"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF08414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="161" mass="17833" checksum="DB50A1D14747D464" modified="2013-05-01" version="1">MADENLTHDELWDDSALVTSWNDAFNEYKKYHSLASRGEKVEQPKQPPTESLKEVAVESKAAAYLNGTTTTTTQPSSNAPINFTTEATPTATTTTATPHTAAGPILPNLPQTLLNGSQNEDLKNIMMSWYYAGYYTGLYEGQQKAWASIQEQQLAQQQEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M3AUF4</accession>
    <name>M3AUF4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">THUMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_151948</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF09129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757250.1">
        <property type="nucleotide sequence ID" value="XM_016907144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AUF4"/>
    <dbReference type="STRING" id="692275.M3AUF4"/>
    <dbReference type="GeneID" id="27904281"/>
    <dbReference type="eggNOG" id="KOG3943">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039352_2_2_1"/>
    <dbReference type="OMA" id="TECFLFI"/>
    <dbReference type="OrthoDB" id="367221at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11717">
        <property type="entry name" value="THUMP_THUMPD1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2300.10:FF:000001">
        <property type="entry name" value="THUMP domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2300.10">
        <property type="entry name" value="THUMP superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040183">
        <property type="entry name" value="THUMPD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13452">
        <property type="entry name" value="THUMP DOMAIN CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13452:SF10">
        <property type="entry name" value="THUMP DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00981">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143437">
        <property type="entry name" value="THUMP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51165">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="THUMP" evidence="3">
        <location>
            <begin position="238"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="142"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="361"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="157"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="376"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF09129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="388" mass="42910" checksum="CB1C377A5AA57B32" modified="2013-05-01" version="1">MNVRPPRAETKGKVQFGQRFCPLAGSSSNTTTTTTTTTTMADSSSIKRKAEAPTGEGEEENSNNKRAKKTKKQWRTPKTGPNGEKSQYPGSHTNTNTNLNSNSTVQAGDTGIFVTCHRGKEGKCTGEVMDLLQDYAERLYSSSASASSSRSAAVKEDGEDDGDGDGDGDGKDDDGNGGEEVVVDDDIEKEILAEVREIRKPKVARLFTPVQLNVQCVIFFKTTSPVEPVSLVKTICSDAMNNKTRKRTRFALRLTPMTLMGRASTEGLEQVALKVLAPHFHQEPFRARTFAIRPTIRNHNVLTRDSVIKQVADVVGEGHKVDLKNYELMIVVEIYQHICGISVVDNDFERLKRYNISELYEPSPKEQQQQQQQQEDVVKHEAEITAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M3AW02</accession>
    <name>M3AW02_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Altered inheritance of mitochondria protein 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Found in mitochondrial proteome protein 29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_91493</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AIM9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758387.1">
        <property type="nucleotide sequence ID" value="XM_016910557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AW02"/>
    <dbReference type="STRING" id="692275.M3AW02"/>
    <dbReference type="GeneID" id="27907694"/>
    <dbReference type="eggNOG" id="ENOG502QV1E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019189_11_1_1"/>
    <dbReference type="OMA" id="WTSHATY"/>
    <dbReference type="OrthoDB" id="2968323at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="7">
        <location>
            <begin position="51"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF10266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="494" mass="56230" checksum="39C2243828A474D6" modified="2013-05-01" version="1">MDPVFNYTSGRWLWNEEAQLAARSISFNVEALKQTACRALHAESCTSLEKIGEGGFNKALRLKMDDGRTIIAKVPHPNAGPAKLTTSSEAATMEYARSVLNLPVPKVLGWSDTKDNVVESEYILMEEAKGSQLSSVWHGLPLEQKVHVVRGIVDVQAQMMSTPFDMIGSLYFGDPGISGCKPIMNDRNIESAHRFSIGPITRREFWQDERASMGHQGPWTSSTDYLQSIADREIEWLRKFSHRHPQSRQPWQHAGPLQDSADAHIASLNKFKAVIPDIVPRDEDLTRPRFWHPDFHTGNIYVDEEANITAIIDWQGAWIIPPFIGINPPSMLDYGVDIMMKLPQNFKSLDEADKEKLRYQVSQSILITAYEAETASINPPLIKMMQTAHGQTLKQLEAFANATWDNTLYPFNETLLRVQNEWSHFGLDRNCPYKFSASEMQQHQDEAENFNDSQRLWHNLRGILSEDGYTTNDEYPQAVKVLKELQNIAERYPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M3AW13</accession>
    <name>M3AW13_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cysteine proteinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_151262</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758397.1">
        <property type="nucleotide sequence ID" value="XM_016906703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AW13"/>
    <dbReference type="STRING" id="692275.M3AW13"/>
    <dbReference type="GeneID" id="27903840"/>
    <dbReference type="eggNOG" id="KOG3246">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043678_1_2_1"/>
    <dbReference type="OMA" id="GFYFEYL"/>
    <dbReference type="OrthoDB" id="5065855at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019784">
        <property type="term" value="F:deNEDDylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.395.10:FF:000008">
        <property type="entry name" value="Ulp1 protease family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044613">
        <property type="entry name" value="Nep1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46468">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46468:SF1">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="6">
        <location>
            <begin position="42"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="226"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="229"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF10276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="283" mass="31709" checksum="57F2FD951A979291" modified="2013-05-01" version="1">MPLTKHNPSPSSSSGRTSGSGFHPFGGRVSRHFGDSLAPDDAYLSYYDVRLTREDVDSIKHDWLTDNAISFWQEYLEREKLTHYPKADIVLLRPTMSFMLQKTHDPLTLKSALPNFEKTTHVFLPINDCQNAAVAEGGSHWSLLLVSCIDGVAFHYDSLNSSNYNEARLVAYKMSQLLGKPLRFINLQDCPQQDNGMDCGVYVCLLMQHLLISKLLRAHAQDKISMSMRGKEVDASGGRKEMIRVIEARRKEGERRRSRSGSPAGKPGTKSKSPPRIGAENET</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M3AY99</accession>
    <name>M3AY99_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DnaJ-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_149139</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760598.1">
        <property type="nucleotide sequence ID" value="XM_016905366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AY99"/>
    <dbReference type="STRING" id="692275.M3AY99"/>
    <dbReference type="GeneID" id="27902503"/>
    <dbReference type="eggNOG" id="KOG0712">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017633_0_2_1"/>
    <dbReference type="OMA" id="KWHEDGD"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004031198" evidence="8">
        <location>
            <begin position="19"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="9">
        <location>
            <begin position="20"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="10">
        <location>
            <begin position="144"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="6">
        <location>
            <begin position="144"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF12477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="404" mass="45493" checksum="EEE1CD0E08483D7B" modified="2013-05-01" version="1">MLLFSTFALLGLLALAAAQDYYKILNLDKSADDRDLKKAYRRLSKKYHPDKNPDDESAAQKFVEVSEAYETLIDSELRQIYDRHGAEGVKQHKERGQGRGGGGRNPFDIFNQFFGGGGHFGHGKRQGPDMEVRIQVSLKDFYTGAEHEFKIEKQVICHKCEGSGSEDGKRDKCAKCSGHGVVIQKQMLAPGIFQQMQMQCDACGGHGETVRHKCKTCGGARVVKSEETYDLSLEKGMPNGATVMYENEADESPDWEAGSLLVHVVASDPQIAAEEKDRTDGTFFRRKGEHLFWREVLSLREAWMGDWTRNLTHLDGHVVQLSRKRGEVVQPGHVEVVPGEGMPVWKDESEAYGALHVEYVVVLPDQMESGMEKEFWGTWEKWRKKIGVDLHKDSGRPAVKHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M3AYN1</accession>
    <name>M3AYN1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_149272</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760783.1">
        <property type="nucleotide sequence ID" value="XM_016905452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AYN1"/>
    <dbReference type="STRING" id="692275.M3AYN1"/>
    <dbReference type="GeneID" id="27902589"/>
    <dbReference type="eggNOG" id="KOG2112">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049413_2_0_1"/>
    <dbReference type="OMA" id="WVFPTAP"/>
    <dbReference type="OrthoDB" id="2418081at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF63">
        <property type="entry name" value="PHOSPHOLIPASE_CARBOXYLESTERASE_THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="2">
        <location>
            <begin position="77"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF12662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="314" mass="35702" checksum="0AA7601A0D01A3C5" modified="2013-05-01" version="1">MIQKRKMATKIEESQPQRDISLTEVFHIVRDEFAAYFASIESSRRTCIETMWKKFVSRWRAAESHTAVHGSNSNDPHYEIYQPTSKHTHTVIFLHGRDSTAKEFAPELLESEDSYSRTLSQALPNVRWVFPTAPIINSARFEQNMSQWFDMHTTEDPHYGELEQNPTQAIDIIYHVLAKEAVLVGGFHNIILAGISQGAAVAIHALLKQQHTLGAFLGLNTWLPNPPAIAHAGKKWPEAVKTPVMLAHTRDDPVINVKYGEELKAHLRALDMDVEWHDYWTNDAKTAHWIHEPEGVDDIVAFVESICQGSYAMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M3AYU1</accession>
    <name>M3AYU1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_9575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760838.1">
        <property type="nucleotide sequence ID" value="XM_016910654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AYU1"/>
    <dbReference type="GeneID" id="27907791"/>
    <dbReference type="eggNOG" id="ENOG502RP6N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2460907_0_0_1"/>
    <dbReference type="OMA" id="WCMEAME"/>
    <dbReference type="OrthoDB" id="4151284at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF12717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="89" mass="9687" checksum="3E9435476C2E6CFC" modified="2013-05-01" version="1" fragment="single">ARPMFLSADKRTISYASNRGSLITLELKNSNAVRSVQEVAKMGIAQKAAGGEEQNKEESPGYWAALLDTLSFYVMEGVEIAAFGPYDEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M3AZC8</accession>
    <name>M3AZC8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Iron-sulfur cluster assembly protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_149421</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7 8">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; iron-sulfur cluster biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the NifU family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760998.1">
        <property type="nucleotide sequence ID" value="XM_016905539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AZC8"/>
    <dbReference type="STRING" id="692275.M3AZC8"/>
    <dbReference type="GeneID" id="27902676"/>
    <dbReference type="eggNOG" id="KOG3361">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079283_1_1_1"/>
    <dbReference type="OMA" id="SMVTEMV"/>
    <dbReference type="OrthoDB" id="1925777at2759"/>
    <dbReference type="UniPathway" id="UPA00266"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140132">
        <property type="term" value="F:iron-sulfur cluster chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1010.10:FF:000005">
        <property type="entry name" value="Iron-sulfur cluster assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011339">
        <property type="entry name" value="ISCU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01999">
        <property type="entry name" value="iscU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY ENZYME NIFU HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82649">
        <property type="entry name" value="SufE/NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5 8" id="KW-0408">Iron</keyword>
    <keyword evidence="6 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="NIF system FeS cluster assembly NifU N-terminal" evidence="9">
        <location>
            <begin position="46"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF12877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="199" mass="21313" checksum="55D6C8402AC98AE3" modified="2013-05-01" version="1">MFKRVLATAPATATSALRTAANSTARNAFIARTSAPIVQQNARRSYHEKVLDHYNNPRNVGSMQKNDADVGTGLVGAPACGDVMKLQIKVGKDKDGQDMIKDVVFKTFGCGSAIASSSYLTELVRGMTLEQAGRIRNTEIAKELCLPPVKLHCSMLAEDAIKSAINNYYTKNPKQKATDLGGTGAHMPKIEVETVSASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M3B138</accession>
    <name>M3B138_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_140895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761593.1">
        <property type="nucleotide sequence ID" value="XM_016902948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B138"/>
    <dbReference type="GeneID" id="27900085"/>
    <dbReference type="eggNOG" id="ENOG502RFQ1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_808983_0_0_1"/>
    <dbReference type="OMA" id="RWETIHK"/>
    <dbReference type="OrthoDB" id="5372859at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF13472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="373" mass="42391" checksum="924CFFF95181CFCC" modified="2013-05-01" version="1">MATLQPQQPSSNLTLTTLPIELILEILPYIPYTAAHSLRALCLTCTSLHRIIVQHEKSLVRSIKTKQAFHLQFQLFPSLVIDSFKGLDLFYRRLERWEVLRGEWGRIVSGSGGGGGATGDDDDDDDDDGERGLEVEWLQGRRWEGIYQMGGLLLYRLGDHQRQQEQEQQQQHQHEEEEREKEKYPSSLINHLPATSLASIYFHIIASIKILRIYGPDPIHQRFCAGDFGVRSDVELALEEMLLTYGPEFFQALLEVGRVGREKKKKKIDRRRDCGSDGDSRGSWAVDALHREIAGMIERQSTLTPEGTPRPPTLTARLRRAFAAKLGLHVTQNVSKMWEIVSSTLFDEMSEEKMVQVVRGEDIGKGGGLKRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M3B1J2</accession>
    <name>M3B1J2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_107647</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761788.1">
        <property type="nucleotide sequence ID" value="XM_016900690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B1J2"/>
    <dbReference type="GeneID" id="27897827"/>
    <dbReference type="HOGENOM" id="CLU_1732615_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004031989" description="Secreted protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF13667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="151" mass="16656" checksum="5E3CF57FB77F6E43" modified="2013-05-01" version="1">MPLFLQPCGPDSGLLSLILLVLALSAPPAFSPPAEFLFTTTYIYFNFTTYHHTNRVLMTSIITPTLSHALWYVALSLHLPIPLPHHMMISCRKTAYLQALGRAGKGMTGDILPRASTNARRGPVVGAYNQVSDITILHISFEAQTLARRTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M3B1W1</accession>
    <name>M3B1W1_SPHMS</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_42949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761903.1">
        <property type="nucleotide sequence ID" value="XM_016908880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B1W1"/>
    <dbReference type="GeneID" id="27906017"/>
    <dbReference type="HOGENOM" id="CLU_183427_0_0_1"/>
    <dbReference type="OrthoDB" id="5372708at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF13782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="62" mass="7142" checksum="FB995C8ADA439342" modified="2013-05-01" version="1" fragment="single">INFTDNFGLYRNIYRALIGLYIINGVFTILERRRRTNIFPLTISPYSSNLEGVIDAISSFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M3B543</accession>
    <name>M3B543_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_146921</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>an acyl-CoA + malonyl-CoA + H(+) = a 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:50252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:50253"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="10"/>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF14892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763013.1">
        <property type="nucleotide sequence ID" value="XM_016903963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B543"/>
    <dbReference type="STRING" id="692275.M3B543"/>
    <dbReference type="GeneID" id="27901100"/>
    <dbReference type="eggNOG" id="KOG3072">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017661_1_1_1"/>
    <dbReference type="OMA" id="HSGAMLC"/>
    <dbReference type="OrthoDB" id="10259681at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF169">
        <property type="entry name" value="ELONGATION OF FATTY ACIDS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="448"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="524"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="452"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="534"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="569"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="597"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="615"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="630"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="662"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF14892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="675" mass="75118" checksum="B8085DFB3606CF12" modified="2013-05-01" version="1">MSGPQIYMRWPSFTLSALNPDPLPAALPPPIRERSFRSPFGIDKDLFNFALKPQVPISFASAYIVSVLLLNAYNRKRNQKPWAVSRQKWFKPFVIIHNALLTIYSTATFLAMCRAFAHTWPGLSNEYGLAGAADALCKIHGPRGLGDAATFNSTINIWEVKNTAIRLGYDGNPDPTDYGRLWNEGLAFWGWIFYVSKFYEVVDTLIILAKGKRSATLQTYHHSGAMLCMWAGIRYMSPPIWMFVFVNSFIHALMYAYFTLTALGYKVPASIKKSLTSLQITQFVWGASYAAIHLFVQYDIPISTPYQVAHTISAIASSATSKAQSATSAVSEAMATPSAVAWGALGKKLLLRALGEEGLAEKVHNKQHQPLNAVMEEKIEQFKEQVPGTPKYETRWRTEWTRTDCLDTTGEAFAVYLNLFYLAPLTFLFARFFYKAYLKRGKSRSAAQGARKVIDSAKEGETKTEEKVEDAGKRLEGKISRINGKEVQQQLRRDVQSLKDGTYRAGRRVSSQIQHLEEQIDNASVKAKQTGKAAAEKTKEAIGEENIRGAENQVQETAEEVKQTSKNVAQQAQQSGKKAAKKAQQASQHAANGVQQESKKAVEKAKQESKKLDTDNGSSSAEKNGSSAQPDDKWFASEKDLENEPPVSQEDRVANSPKVKQSKGDFDAERIHKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M3B5F6</accession>
    <name>M3B5F6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_147002</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763128.1">
        <property type="nucleotide sequence ID" value="XM_016904021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B5F6"/>
    <dbReference type="STRING" id="692275.M3B5F6"/>
    <dbReference type="GeneID" id="27901158"/>
    <dbReference type="eggNOG" id="ENOG502QQTI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007201_1_0_1"/>
    <dbReference type="OMA" id="DWHPRNL"/>
    <dbReference type="OrthoDB" id="2262349at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009074">
        <property type="term" value="P:aromatic amino acid family catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000012">
        <property type="entry name" value="C6 transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052780">
        <property type="entry name" value="AAA_Catabolism_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR ARO80-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR ARO80-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="26"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="63"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="193"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="235"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF15007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="966" mass="107065" checksum="7319E80F487C8B4C" modified="2013-05-01" version="1">MNGPSASPPRPQQEPNAVVHQRTYQACIPCRQRKVRCDLGSVDNPHDPPCTRCRREAKECYFSATRRKKKAQSEEHGSDAGDASVYEVRQNRKRPRTSAPAASLDGRNEEDEYEEPPRTPGGSIGRTAPLRRPAAPKHIEYGDEDVKAAQHTARILQQAEVHGGHDALKVLYQAAVHGRSDSMTSNSVRPAFASGITSNSLPPISSPDGLTRSESYTSYNNGPLGAVTSRDGTWKTPTDQPSPSSNSILAATSYEREALALAMKAWSRFRFVRAGWFTAKEGIDYILYFYKHLSPLTPVALPDFQHPTTHKTLLEEEPMLAITMLLIASRHMKLDGPGSLSRPNAIHHKLWQYLSGMIDRVVWGQEQFGGGFCGAGGPGAQPCSDVNPLTRKGLRTLGSVESLVLLTEWHPRAMHFPPDEDDDDLMIPDEAWVPQMNVEDGVPRGIGGHRMDAWLEPCWRSDRMCWMLLGMAMSLAMEIGVFDSSEWQRHATGPNGQPLSAGQLSEYDRRRGNVRNLLLVYVTQTSGRLGLTSMLPGYYSKPEDSDLFRRQLGQQDSVHETTFHFWLRMAALMREGNNKIFANKTFTRDLIRNGNYKAALDQFAGPMNQWRTEFDEARSIPKHMRAILEIEYEYCRCYLNALSLQAVAERCANEHPSPEQVLDPPLEMARSAIEADGNKSEIAIAPTTLSKWLGGDRQYVLNVGDAARKLLKVVVDDLYPDEALRHAPVRTYFRIISVAIMLLKSFALGATESDITESLKLMDRTVEALRTCIVDDVHVASRFADLLDTLSSNLKPRLVRIAADGRAGRSRRQSNHNLDPAMAMSDRRHVQQSPQAVAGAMPSNQQWSYNSTMMPPSNDMNNSPLFGISGISNDYHDLMGTDNSYSVMPPPGFSQSSPNTLNGAGGSYDSYSANGTFSGDWLALPLDPLLNMSGADVDQTMYGPQLGGHDMLEYLLANPEASNGFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M3B5N6</accession>
    <name>M3B5N6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_147072</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763228.1">
        <property type="nucleotide sequence ID" value="XM_016904066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B5N6"/>
    <dbReference type="STRING" id="692275.M3B5N6"/>
    <dbReference type="GeneID" id="27901203"/>
    <dbReference type="eggNOG" id="KOG1488">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004017_4_2_1"/>
    <dbReference type="OMA" id="MIMAELM"/>
    <dbReference type="OrthoDB" id="668540at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF12">
        <property type="entry name" value="MATERNAL PROTEIN PUMILIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PUM-HD" evidence="5">
        <location>
            <begin position="516"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="537"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="573"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="609"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="645"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="681"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="717"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="800"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="75"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="189"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="415"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="906"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="206"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="244"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="417"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="906"/>
            <end position="931"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF15107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="962" mass="106593" checksum="FF4DA72AF54A53FC" modified="2013-05-01" version="1">MSHGASSTTNTSNSNMAFANAARSFNDVRNTHTADKKIGTNGMLKPAATGNTWGFSSIWSGGANGSNISTNLRETSRSRDHTLQVKTPQHEEIEGKTGSGSLVDSSVSEDFVDRGWATRIPASGRPMPTGRHTDNTLLQQRSASNAGLQTMPAAHTSLMSVGSRHQFSNSNQTATAQSRQRYNSTFEYKNDFAAQPSEQPPFKVYTKHDRPVDPAHGKPDSANGYSSTTPSPCEERRPPFSLQYGRTASMPTSQDGSLPPSRGAEEANTWTPIDYSSRSSQRVTPDTSRAPSVSAKGNGAYNPYFNVNVDAMSSNLRQLNINDNSRPSTSYKQSFGLQSYSGFQGASQPAMARPGQYREDDMDPLDRANMQYLELEDYARDLPTNNISSSSLAERCLNGGGMHEFRPGQPYVGSGMSCRSQDRTNGSRTPSEWQSFSGGAQLTNRRSPAVAEQPSYLDPRFQQFMAAQFHARHPYGMYSPYALQQLGQQYVQLMPLATTAFDMPATPRDSPITDCVQSALMYEFKSNTKTKRYELRDIYEHIAEFSGDQHGSRFIQTKLETANSDEKEHVFREIEPNAIPLMTDVFGNYVIQKFFEHGDQTHKKILANKMRGQVLALSLQTYGCRVVQKALDHVLVDQQRELITELENHVLKCVKDQNGNHVIQKVIERCQATTIGFIVTALQGQVQQLSIHPYGCRVIQRCLEKSDLPSKSMIMAELMQGIPSMIADHFGNYVVQHVVEHDGGGEGRQQVLNIVASGLEGYSKHKYASNVVEACLVHADDLWRQRVMYQLLEANARRTEGEGVLVGMIRDQYGNYVIQKFLDTLVPNDFNRFLGPLHPAMAQAKRGCPVKHIISIEKKMHRFDPHRTSSINHGHGLPFHGRNGLDFPLPMQVPMQMPMAMQPFGTNYHSTATTPPPLTSDTQSLQSSCLPSVNGDAVEGAASSRKGSDPSSLYSIDDVQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M3B5N9</accession>
    <name>M3B5N9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_147076</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cclA family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763233.1">
        <property type="nucleotide sequence ID" value="XM_016904069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B5N9"/>
    <dbReference type="STRING" id="692275.M3B5N9"/>
    <dbReference type="GeneID" id="27901206"/>
    <dbReference type="eggNOG" id="KOG2626">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014420_3_0_1"/>
    <dbReference type="OMA" id="GFRYTYA"/>
    <dbReference type="OrthoDB" id="10266026at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12872">
        <property type="entry name" value="SPRY_Ash2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037353">
        <property type="entry name" value="ASH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10598">
        <property type="entry name" value="SET1/ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10598:SF0">
        <property type="entry name" value="SET1_ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPRY" evidence="5">
        <location>
            <begin position="190"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="488"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="561"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="259"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="373"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF15112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="585" mass="64261" checksum="292192E12CD41077" modified="2013-05-01" version="1">MAEGNGVTTLPATLEQASRAPAPPPPPPIQREQREKKESLKKRESMGLGAFEDKKSTSSLGKRKASTKQHTYPSPMRFSVPPPKAEAFEEPKEDSMVSHEPVPLTMPDSDRQLYKPIDLAENKRGYRYSRAIADPTFPHKQFYRSTSPPPHYARLSFEDADKWMHFTTNALVTTNEKGWRMVRSNVCAREGTLYYEIKVHRGVPPEGPDPAANGPEPHVRFGWARREAPLDAPVGFDGYSYGITDIRFETMHRSRPGKFYNPKKAKSKAAAKNGPTPLVLAPEDQHVKEGDVIGVEIQLPSLSLHRKVVDGIYNHAVDSGDGFDQGSHQDADTQPMDIIRDRIPVAYKGNSYFEVLDHVASKPMEIYADRTTNLNHLPTNGPSSNKESIKTAPNPHNEYPALRTLPHSAIRVYKNGKLIGVAFENLLAFLPPASAPSKTMGAREGFDDGLTGYFPAVSCFFGGIVEVNFGDSANGFWCPPAHLRNTRDTTSAAAAGQGPDIDMPDAGADASGRKNGWNPGRQLRGVGERYKEQIAEDIIWDLIDEADFFVQDGGYDGVVGSGAVNGDERGAPSSVVKGSRLKEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M3B8G2</accession>
    <name>M3B8G2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DnaJ-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_81617</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF16142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764263.1">
        <property type="nucleotide sequence ID" value="XM_016910280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B8G2"/>
    <dbReference type="STRING" id="692275.M3B8G2"/>
    <dbReference type="GeneID" id="27907417"/>
    <dbReference type="eggNOG" id="KOG0717">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009539_2_1_1"/>
    <dbReference type="OMA" id="RANHEES"/>
    <dbReference type="OrthoDB" id="5894at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051964">
        <property type="entry name" value="Chaperone_stress_response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054076">
        <property type="entry name" value="ZUO1-like_ZHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44029">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44029:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21884">
        <property type="entry name" value="ZUO1-like_ZHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="6">
        <location>
            <begin position="23"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="316"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="495"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="355"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="516"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="390"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="401"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="437"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="463"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="478"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF16142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="535" mass="59942" checksum="A4178B7497799F76" modified="2013-05-01" version="1" fragment="single">MGQGQSSSSEGGGSAAPVQAKTSYYTLLGIERTATEDEIKKAYRRKALELHPDRNYGNVEDATKLFAEVQSAYEVLSDPQERAWYDSHESSILSGQDAHDQGAVPTYQNVKITTANDINQIVGKFNRNVDFTDSPSGFFGFLRELFDHLAQEEDIAGQMENVDNPEYPTFGHKDDDYPDVVKKFYAAWSGFSTVKSYSWCDRWRLSEAPDRFIRRRMEQENAKCRKDGRDEFNEAVRTLVQFVKKRDPRVVVDTRTEEERSKALRDAADSQRRRAMEMNAAKLNEAAPEWTKSRDPDEYAEFEGTFDSDTEEEEVFECVACNKIFKSEKQMDAHEKSKKHQKAVKDLQWRMRKQDANLDLNGSGAATPDIEEDEVEVAENSAETSSELDHDLEVDDEQQELAATNHSPTEVASDSEDEDEDYATRETVEARIAATTLHDSTTLPSTPALSDDEEHNDDWSAQPKKKLGAAAKKRAKKAAAAAAETSGAQTAAGEHRCTNCSAQFESKTKLFEHLKQNPKHAALKTVSGEGGTKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M3BRA0</accession>
    <name>M3BRA0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ATP-dependent RNA helicase DOB1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_152259</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756769.1">
        <property type="nucleotide sequence ID" value="XM_016907335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BRA0"/>
    <dbReference type="STRING" id="692275.M3BRA0"/>
    <dbReference type="GeneID" id="27904472"/>
    <dbReference type="eggNOG" id="KOG0948">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002902_0_1_1"/>
    <dbReference type="OMA" id="IMLKNYN"/>
    <dbReference type="OrthoDB" id="64767at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18024">
        <property type="entry name" value="DEXHc_Mtr4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13154">
        <property type="entry name" value="KOW_Mtr4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.30:FF:000003">
        <property type="entry name" value="ATP dependent RNA helicase (Dob1)"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="2.40.30.300:FF:000001">
        <property type="entry name" value="Mtr4 exosome RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="Beta-barrel_MTR4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048392">
        <property type="entry name" value="MTR4-like_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF7">
        <property type="entry name" value="EXOSOME RNA HELICASE MTR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21408">
        <property type="entry name" value="MTR4-like_stalk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="MTR4_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="167"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="436"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="741"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="749"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF08648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1084" mass="122272" checksum="9A0FC5850460226F" modified="2013-05-01" version="1">MDDDLFNVFDDKPQPANSNKTNLKRSLNGNVKQNGGDSVMADAPVETKDFANTVAAKGGDKKGNGDDEANGEQEEGQRGQKRQRMEDAPDAVVTDEFETEQQREVAASAGLQAQQDGSAAVTLKHQVRHQVSLPPDCDYVPISQHKRPEHPAKVFPFTLDPFQEVSVASIERNESVLVSAHTSAGKTVVAEYAIAQCLKNNQRVIYTSPIKALSNQKYREFNAEFGDCGLMTGDVTINPTATCLVMTTEILRSMLYRGSEIMREVAWVVFDEVHYMRDRARGVVWEETIILLPDKVRYVFLSATIPNAMQFAEWITKIHNQPCHVVYTDFRPTPLQHYFFPASADGIHLIVDEKGVFREENFNKAMAAIADKAGDDGSDPLAKRKGRGKDKKTNKGGKKDGPTDIYKIVKMIMLKNYNPVIVFSFSKRDCENYALQMSQLAFNDESEKAMVSKVFDSAIEMLSDEDKQLPQIQHILPLLRRGIGIHHSGLLPILKETIEILFQEGLIKVLFATETFSIGLNMPAKTVVFTAVRKFDGRELRWVTPSEFIQMSGRAGRRGLDERGIVIMMIDEKMDPPVAKEIVKGEQDKLNSAFYLGYNMILNLMRVEGISPEFMLERCFFQFQNAASVSSIEKQLMELEQKRADAVIEDEAQIKEYYDLRQSLETYSSDMKKVISHPQYLCKFMQSGRLVKVKHNGQDFGWGVVVNFMKVKPARGQSEDDMNIGHSVVIDVLLNIAADSSAPGTSSQLRDDMPKEVRPCEPGEKGKMEVVPVMNGTIDAVGHIRVFLPNDLRTSEQRNTVRKSLEEVARRFPDGVAVLDPIENMGIDDDSFKKLLRKIEVLEHKLLNNPLHTSDKLPDLYDRYAAKIEITNEIKATRKKMTDALSVLQLDELKNRKRVLRRLGFVNEADVVQLKARVACEISTGDELVLSELLFNRFFNELTPEQCAATLSVFIFEEKSDEAPALKEDLAKAFREIQAQARQIAKVSMECKVLVNEEEYIQGFKHQLMDVVFSWCNGASFAEICKMTDVYEGSLIRLFRRLEELLRQMAQASKVMGSEDLEKKFEGALGKVRRDIVAAQSLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M3BRN8</accession>
    <name>M3BRN8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nucleoporin Nup159/Nup146 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_92921</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756904.1">
        <property type="nucleotide sequence ID" value="XM_016910598.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.M3BRN8"/>
    <dbReference type="GeneID" id="27907735"/>
    <dbReference type="eggNOG" id="KOG3630">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003852_0_0_1"/>
    <dbReference type="OMA" id="RGQCASI"/>
    <dbReference type="OrthoDB" id="248320at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026054">
        <property type="entry name" value="Nucleoporin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039462">
        <property type="entry name" value="Nup159/Nup146_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23193">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23193:SF23">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16755">
        <property type="entry name" value="Beta-prop_NUP159_NUP214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup159/Nup146 N-terminal" evidence="6">
        <location>
            <begin position="44"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="492"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="615"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="669"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="719"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="766"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1440"/>
            <end position="1469"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1295"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="503"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="547"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="631"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="675"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="733"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="791"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="842"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="905"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="933"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="987"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1019"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1063"/>
            <end position="1077"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF08783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1511" mass="159941" checksum="E3B09080F5B500A4" modified="2013-05-01" version="1">MNMGSQAQAGEELGEVISDEISLDDVASKPGDRVRVSSAWSPPPHPWASLLSVASTKGLLAVAGPDSLIIASTKQVRQKQYIPKRKDGASGDEKYLPITALNTLTAPRLSHVAFTADESCLIIASEQGGGLAVYETEALTRGGKDPAFELSTQNTGIRHLLPNPNKEAGTAHFVGVVLTNGQLVVADLQKREMVQGASGVVFHRDVVSACWSKKGKQIVVGRQDSTCAQIDPLGVVKAEIPAPPQLRSIKDDQYQSAQKMPVTAIHWLETYKFFIVYTPFFSADNTDDMLVHDSVYFIAEKNGKDGPFVFSKSSMDPCMVPQQGQDRVPANHFIQRVGAWDPQVKDLLVVVSTACSDGGTFVQLQNEQSFSLSAPLDENRKITLPMSISGEDESSAIGMALDFSAEELEPRPIPNDIDRFPQATKPLPCLFVVTTDGMLCMWWVVSKSAVEQEIIHANMVNTSGPYTDYPSLRNLASTEIATEDIPDHYKTAEEKAAEASGTKHAQTTTPMASSLFGAKPETPASPSGSLFSKPAAPGFGQSTFGQPTTISTNPPSTSSTFGQTTFGKPNTPVAPAQGQPAFGMTNTLGASAGSAWAAQGKATFGSTSQIGGGTGFGSVGGMGSTKPSVWGTPSGTTATTGQSPFTQPSAKSSGFAAFANKTPFGGAQATAASPFGSSARNQSSNPFAASPFGNGANNTGTSFASSSFGKPSFTQQSAVSSAGTLGTGSFGKPSSLGNPSSLSNTSSGLSGLDGFKLGSGFVGDGSAKDDLPKPKNPGGDLFGADFLAGAEAKKSEVKPEPGTEKSMALNDIPESKSSANDGSGLPPDPTVFNYKKAQAAMAPPPGVTQPPSKPIEAREDATAAPLPPDPSSFNYKKALADMGPTPGAAAAQSEEVKDIPIAGSPPQNITHSETFSPAGSEAGGPTDDGSVAWDDEEEEDEEADDDEADDEEGEGDEDEGDETDAIETNDEEGDDETDQFETEPEEESAHEQSREQNEPGARSKLEAALKASRLGKSAPKSPETSKTKASTTTPGSTDTSYTPKELPPGPVLQPTGPRQTGDSPRSPSPQRRIQQQRAATNPVPSDFLRIPSSQIKVTSVPLATPIERPTPPPQPKEPTLGELADDAAAAAKAVLAAPIEPTKKIPDFFVHQDYVAGVDTPGIGGQIEIVFRDVNAMVDVVGLNGRSLQSLIEGHKQLRKPGQRSVKDLEDDDAWTLAEMSELSEVMDHIDKQLANGKLVNVPDLLARLKEEHEDINKTRTRTVEMRRQIAQHTDPARVAERDAAPLSAETLHQQSDLRTRLQSVQKLLSEAEQMVTMLRAQLSSLQSKNPKSGQAAPVPTVEAVERTILKLTAMVQQKSGDIDHLESQIRSLPGGMGALRLDDDYEEDLAARLGGSKLLSLAESVGRRRTPQKYPRMAANGDALGMSAMFGVSTRFQTPPSASIRGSPSFRASALGRSTGSLSGSARKKMVDVTEQEIEAFRTRTQRRKDVLNALNEKVEKRGTRVVKPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M3BS28</accession>
    <name>M3BS28_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Kazal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_111388</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757024.1">
        <property type="nucleotide sequence ID" value="XM_016900914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BS28"/>
    <dbReference type="STRING" id="692275.M3BS28"/>
    <dbReference type="GeneID" id="27898051"/>
    <dbReference type="HOGENOM" id="CLU_1620358_0_0_1"/>
    <dbReference type="OrthoDB" id="3924764at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004031546" description="Kazal-like domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF08903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="137" mass="14677" checksum="F4965C438C77D5A4" modified="2013-05-01" version="1">MFTLTTLLAASGFLLSTSHALEFPDSSCAICPPDNQTLTACGQRFGSCYDFCAESRKEFPVPECNGVSDEVLICEYFKSDCGELYGGCYSNKGPIPGWAVPTCPPESEPSKPEPQTAPKQDPTCQICVDNINDCGAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M3BS96</accession>
    <name>M3BS96_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CRAL/TRIO domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_52561</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757079.1">
        <property type="nucleotide sequence ID" value="XM_016909233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BS96"/>
    <dbReference type="STRING" id="692275.M3BS96"/>
    <dbReference type="GeneID" id="27906370"/>
    <dbReference type="eggNOG" id="KOG1470">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016665_3_0_1"/>
    <dbReference type="OMA" id="ISTMRWR"/>
    <dbReference type="OrthoDB" id="43460at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120010">
        <property type="term" value="P:intermembrane phospholipid transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052432">
        <property type="entry name" value="PITP/CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46590:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN CSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46590">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN CSR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="197"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="435"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF08958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="450" mass="51098" checksum="CA249B0C6A8E3E06" modified="2013-05-01" version="1">MAAPYGNAPGRPGNLTPEQESKLKEMWIALSDVAGIDHATNGGTRSRASSDIRPDSSGGDTPNKRKSRFGLGRSKKDKSEDTNGVTNDKHGQTKEYEQALASLSPEQIRDALWTFSKHDDPDALLLRFLRARKWDVQNALVMLISTMHWRLVEQHVDDDIMLRGEGHAFRESQSSNAAEKKEGDDFMAQLRMGKSFLHGVDKAGRPCCYVRVRLHRQGEQSEKSLERFTVHTIETARMMLRPPVDTATIVFDMTDFSMANMDYTPVKFMIKCFEANYPESLGSVVVYKSPWIFQGIWKIIKGWLDPVVASKVHFASNVSDLEEWIPRSHVMKELGGDEDWTYSYPEPREGEDNAMQDTQTRDKYLEERKDLADQYEKATSAWMYGGDDGKDRTELSRKLAENYWKLDPFLRARSMYDRTGVLKEGGKLEFYPKQAPATAPTATTADNDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M3BT65</accession>
    <name>M3BT65_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein S28e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_127607</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS28 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF09855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757976.1">
        <property type="nucleotide sequence ID" value="XM_016902164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BT65"/>
    <dbReference type="STRING" id="692275.M3BT65"/>
    <dbReference type="GeneID" id="27899301"/>
    <dbReference type="eggNOG" id="KOG3502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_178987_1_0_1"/>
    <dbReference type="OMA" id="NTGMHGE"/>
    <dbReference type="OrthoDB" id="10258930at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04457">
        <property type="entry name" value="S1_S28E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000025">
        <property type="entry name" value="40S ribosomal protein S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000289">
        <property type="entry name" value="Ribosomal_eS28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028626">
        <property type="entry name" value="Ribosomal_eS28_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10769">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10769:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01200">
        <property type="entry name" value="Ribosomal_S28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00961">
        <property type="entry name" value="RIBOSOMAL_S28E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF09855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="67" mass="7540" checksum="09C8979F5D818A18" modified="2013-05-01" version="1" fragment="single">MDSAKVPVKLVKVIKVLGRTGSRGGVCQVRVEFMDDTTRSIIRNVKGPVREDDILCLLESEREARRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M3BTC4</accession>
    <name>M3BTC4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Phosphomannomutase</fullName>
            <ecNumber evidence="5 13">5.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SEPMUDRAFT_151012</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>alpha-D-mannose 1-phosphate = D-mannose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11140"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="EC" id="5.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the eukaryotic PMM family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.8" evidence="5 13"/>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF09910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758031.1">
        <property type="nucleotide sequence ID" value="XM_016906540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BTC4"/>
    <dbReference type="STRING" id="692275.M3BTC4"/>
    <dbReference type="GeneID" id="27903677"/>
    <dbReference type="eggNOG" id="KOG3189">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065642_0_1_1"/>
    <dbReference type="OMA" id="ISHRVYT"/>
    <dbReference type="OrthoDB" id="10264771at2759"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00424"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004615">
        <property type="term" value="F:phosphomannomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02585">
        <property type="entry name" value="HAD_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1240.20:FF:000001">
        <property type="entry name" value="Phosphomannomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005002">
        <property type="entry name" value="PMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043169">
        <property type="entry name" value="PMM_cap"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10466">
        <property type="entry name" value="PHOSPHOMANNOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10466:SF0">
        <property type="entry name" value="PHOSPHOMANNOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03332">
        <property type="entry name" value="PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00445">
        <property type="entry name" value="alpha-phosphomannomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01143">
        <property type="entry name" value="C2.B.3:_Phosphomannomutase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01140">
        <property type="entry name" value="C2.B:_Phosphomannomutase_and_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="27"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMF09910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="270" mass="30157" checksum="2D55F00B5103E826" modified="2013-05-01" version="1">MAAAAASVVPGLDQRPVKNTICLFDVDGTLTPARRTVSPEILQLLSALRHKVAIGFVGGSDLVKQQEQLGTASIPVTSLFDFCFAENGLTAYRMGVPLASHSFIKWIGEENYKKLAKFILHYIADLDIPVKRGTFIEFRNGMINVSPIGRNASVQERNEYEKFDLEHGIRKKFVEDIKKEFPDLGLTYSIGGQISFDVFPQGWDKTYCLQHVENEKNLPGGVDYTTIHFFGDKTYKGGNDYEIFEDPRTIGHSVTSPDDTAAELKKLFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M3BVM0</accession>
    <name>M3BVM0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sugar_tr-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_150319</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759490.1">
        <property type="nucleotide sequence ID" value="XM_016906089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BVM0"/>
    <dbReference type="STRING" id="692275.M3BVM0"/>
    <dbReference type="GeneID" id="27903226"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_43_5_1"/>
    <dbReference type="OMA" id="GKHAKGF"/>
    <dbReference type="OrthoDB" id="5290825at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000474">
        <property type="entry name" value="Sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF13">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="415"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="439"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="468"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="509"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="540"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="120"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF11369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="641" mass="71012" checksum="46CB5FE90FE153B5" modified="2013-05-01" version="1">MAEKAYVTDTGVEHNEKNPPEYHESAARPADTSGRRASVALNIVENPLRRDSPEKVVAAARKFAEENGLQDKATLFGQAALVARDPTSFAAIDGLDEDQINALAYERDHKWHGPAMLWYSISLCAIGAATQGWDQTGSNGANLSFPQEFGIAREGNQRDEWIVGLINSIIFLTAGLIGAFIVDPLNKYFGRRGEIFITACCLTATPIGSGFAQSWQGLFAARFVMGIGIGAKNATVPIYSAEMAPARIRGALVMFWQLWVVIGIFLGFCANVIVKDVTVVSAWRLQLGSAFIPSFILGVGIFFCPESPRWLMKNGRMKDAFTSMSRLRAHPIIAARDFYYSVVIYEEECKLSQNTTYFSRLWDCFSIPRIRRANYGASTVMIAQQMCGINIISFYSSTIFTNVGYTATQALYASLGYGAIQVVFTIPTLFLIDTKGRRTLTLITFPIMCITLLAAGLSLLVPDTASKGAQIGPVVLFVYLFTIAYSLGEGPVAFQYSAEVFPTIQREQGMAWAVCINNTFAGILSLTFPRMTTVMTQTGAFGFYAALNLIAWFMIFAFVRETKQLTLEEIDQVFSVPTKEFLAYETKTWLPYFVKRHILRRRIEKPPPIIEKADRFSDEEERVAAGQDVRNRLSYAPAGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M3BY53</accession>
    <name>M3BY53_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_149505</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761112.1">
        <property type="nucleotide sequence ID" value="XM_016905595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BY53"/>
    <dbReference type="STRING" id="692275.M3BY53"/>
    <dbReference type="GeneID" id="27902732"/>
    <dbReference type="eggNOG" id="KOG2741">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_7_0_1"/>
    <dbReference type="OMA" id="RHIQEAN"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43054">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43054:SF1">
        <property type="entry name" value="SCYLLO-INOSITOL 2-DEHYDROGENASE (NADP(+)) IOLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="2">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="3">
        <location>
            <begin position="133"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF12991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="338" mass="37575" checksum="B3E6D1B8BD789A34" modified="2013-05-01" version="1">MAITYGVIGTNWITDSWIQAANKTGQWQLQAVYSRTREQADKFASKYACSKLYTTLDDLAADQDLQAIYIASPNSLHYEQAKQMLKAKKHVLLEKPATSTPAELDDLFRIAKEEGVYLIEAYRHIHEANYKLLRKMVHEEKRLGPIYGASFSYCSYSSRYNNVLNGETPNIFSLDFSGGSLVDVGVYPVTFAVALFGRPQTQSYIPTICRTGVDAGGCGILQYDGFGVQISASKCYQSTAPCEIYGEKGTLTINATTDIASIAHWSPQTKKSEELAGPCKTVEKPNVNMEEEAAEYARILNEKDTASLQELETISRNVIHVTSEMRRQAGIVYPADKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M3BYV6</accession>
    <name>M3BYV6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_64017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761382.1">
        <property type="nucleotide sequence ID" value="XM_016909666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BYV6"/>
    <dbReference type="GeneID" id="27906803"/>
    <dbReference type="eggNOG" id="ENOG502SU4S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_580055_0_0_1"/>
    <dbReference type="OMA" id="KIVIHMP"/>
    <dbReference type="OrthoDB" id="2951834at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF7">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="253"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF13261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="460" mass="50424" checksum="DFBDF6DAF1C2370B" modified="2013-05-01" version="1">MARPAPSPAPIDKPAPLSTSSTVNDSGRIMKPHSAGTQSIRNTRQRTRMLAQASSNAVLESMGDERSCGPADSSASEYQYGNENGKGKGKLCDIRLGTVTMLEEITATGPEWCPITDKDTHPFPIMELPTEIRLEIYRACLTRPYKILLSKRELPLLAKDDGDFLNPAISLDYEYGSDERDGAVQDRPVRIATASPVGSASTASTRRMFPQLRIVGATRGGRSHRTTSSATVSGSSSVAGTTATDVGSSNVQTGRSSTSSTGSRPASRPTRHVAIDSRRHVTQPEPQRNQSQDPLITNVLRASKEIYKEARGVLYSENHFVLDLNTAMQTLGHLHQRSRRQIKHVELEIPTYNEILERFQETVRLSLRYCSGLKKFIINMPFTLPGADGSGTTGNTTVYANGFDILRWLPQECDIIVQGNICTEIETVVQKHLRLSKTLDKLAYARRQLISNDAGPPSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M3C2T4</accession>
    <name>M3C2T4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">beta-glucosidase</fullName>
            <ecNumber evidence="4 11">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SEPMUDRAFT_148250</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="4 11"/>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762702.1">
        <property type="nucleotide sequence ID" value="XM_016904803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C2T4"/>
    <dbReference type="STRING" id="692275.M3C2T4"/>
    <dbReference type="GeneID" id="27901940"/>
    <dbReference type="eggNOG" id="ENOG502QR4D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_2_0_1"/>
    <dbReference type="OMA" id="HNISATC"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000003">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF29">
        <property type="entry name" value="BETA-GLUCOSIDASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 11 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004031684" description="beta-glucosidase" evidence="12">
        <location>
            <begin position="18"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="13">
        <location>
            <begin position="813"/>
            <end position="881"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMF14581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="891" mass="96666" checksum="719C9DB8C780E909" modified="2013-05-01" version="1">MPSVKAALLAAATSVAAYDYSQLASSKNNYGAPNPDTTYPGFESQNPAAVAGSDSFQISPPKYPSPWMDSSYGNWSAAYQKAFAFVEQLTLAEKVNLTTGSGWQLEACVGNTGQVPRLGFRGLCLQDSPTGVRMTDYNSVFPAGVNVGASWDRQLAYDRGKAMAEEHRGKGVDVLLGPVAGPLGRTPAGGRNWEGFSPDPVLTGQLFAESIKGIQSAGVVATGKHYIMNEQEHFRLVPESKSYGFVNITEPSSSNLDDETLHELYLWPFADGVKAGVGSIMCSYNQVNDSQACQNSYVLNYLLKGELGFQGFVMSDWLATHSGVSSALAGLDMTMPGDGTAFNVADSFFGTNLTVAVLNGTVPAWRIDDMALRIMSAFFYVDGQVEREPENFQSWTTDTFGWAHWYNKEGGIVQVNQHVNVQGDHGKLIRQWGAESTVMLKNKGVLPLTGKEPLTAVFGNDAGPNLAGPNSCTDRACANGTLGMAWGSGTAEFPYLITPDTAIQNEVRANGGAYESSLNNWDLGPAGKLARRANVSIVFASAVAGEWYLETDGNLGDRNNLTFWQNADEAIERVAANCSNTILVVHSVGAVMLEKYQNHPNITAILWAGVPGQEAGNSIADVLYGRVNPSAKLPFTMGKDRKDYGADILYTPNAPVAQINYKEGVFIDYRGFDKHNTTPVYEFGYGLSYSTFNYSSLQVTKLNAPAYEPFTGMSKPAPTVGNFSTNAEDYLFPANFTKFTGFHYPFLNSTDFAQATGDADYGMNFTWPEHATDSSAQRMPKAGGAPGGNPRLYDILYTVSATITNTGKVAGYEVPQLYISRGGPYDPVRELRGFDRIWLEVGESKTFTVDVTRRDISSWNTVEQDWFVRNSTKKVWVGSSSRNLPLSATLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M3C3F4</accession>
    <name>M3C3F4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_132390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762927.1">
        <property type="nucleotide sequence ID" value="XM_016902491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C3F4"/>
    <dbReference type="GeneID" id="27899628"/>
    <dbReference type="HOGENOM" id="CLU_1971870_0_0_1"/>
    <dbReference type="OMA" id="REEKCRT"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF14806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="127" mass="15973" checksum="DDFA86CED1BD5EBE" modified="2013-05-01" version="1">MYLRQNIRILPASITRATRQDETRATRQDETSATRQDKTRRARRDKTRRDKRDEIRRDERDETRRDESDKTRQDETRRDESDKRGERQDESNETRRERRERRERQDKTRQAQRDKTRRARRDETRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M3C456</accession>
    <name>M3C456_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ER transporter 6TM N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_147029</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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</entry>
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                <person name="Barry K.W."/>
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                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
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        <source>
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        </source>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="79"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMF08225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="557" mass="61626" checksum="470EE4BC0FDEA321" modified="2013-05-01" version="1">MESNKTLPPGTVRLIDNDRTLSTKHGNGSEQDIVLVPTPSEDPEDPLNWTYRRKMLATSCVMMYTLMIALPSGSVYSVVKPIEKATGLTLNDLNTGTGVMFLAYGWACVVWQPLALQYGKRPAYLFSMLASIAIMTSAPWCTTRSTYLANKVLQGFFGAPVEALCEISITDIWFAHERPKYLAWYGFGLSVTGKLAPMLAGFINDGQDWRWVLWWTAIWIAIAFVYCFFLMEETNYDRTHHTPTHAPASEVVVSELTSGINSTTVHEKDSKPLDALSSSSTSDREPGQILPLYPRKSYWQKLRLFPYANNNKSRPNRMLDIFLAPFKGFTYPVIVYAGLMYGANALVWSGVQNATTGTVYTTLYGFSTTGIAAAYSAGVIGAILGGYYCGKMGRILTVKLARQKGRDGISEPEDTLYMFVASMILVPFAMLLYGLGVTYRVHWFALVFSQGALAVSNCLCVAGGIGYAISSYRELSGDMVTTLILIRNTLSFAVNYGITPWLNALGYRNTFIMVAVIGFAWNASLFIMVRIGPRLRASSAERYWKDVAKARAKGLGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">ClpP/crotonase</fullName>
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        <name evidence="2" type="ORF">SEPMUDRAFT_152237</name>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">SO2202</strain>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF08620.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="276" mass="30544" checksum="8FF254FE868416FB" modified="2013-05-01" version="1">MSQKYSDIIVTIQDGIGTIKLNRPKQLNSFGGSLVEDTIAALRELDNHPDTTFTVITGEGRFFASGADVTGIANTPSTFQNDGQKKIFWMQRFAVGMELVRAMIDHKKVLITAMNGPGVGAGAAWFQGSSDLLYAVEGTWLQVTFSQMGLVPENGSAVNWAHSMGSHRANDWLLFGGKATVEELKEAGLVNKIFPKENFHAAVHAHLKEMLRERSGKSMMEMKRLSNKATRDARILALYDSMDALAERFVEGEPMVRMKAKMDELAAKREKRSSKM</sequence>
</entry>
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        <submittedName>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000016931">
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    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF09842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="121" mass="13042" checksum="9D770929C32D23A6" modified="2013-05-01" version="1" fragment="single">IRSIPQPHSYQHTLTNTHTHLSTNKSLSTCSSPPSSPQLLLSLAPLPPQSRSDTLHQCTQSPTAPQLLVLLLQAALDPLQAPLLPSKVVLLKSLVAPLPWVSCLSAVLLLLSKQPTHRPAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M3CD63</accession>
    <name>M3CD63_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_150049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016905935.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="27903072"/>
    <dbReference type="HOGENOM" id="CLU_1548581_0_0_1"/>
    <dbReference type="OrthoDB" id="3641146at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF11006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="173" mass="20548" checksum="C2613A2350D03346" modified="2013-05-01" version="1">MFVQPALYPVDFSVLPPSPTGRKKKKGKVMEMEKQHQHQQQQQQHLKNHSNNNNEQCNKNNENRPEKEMTIMVRILTTTTDDDEDKKKTKKEKEKEREWPLWTLKWFTHQHRHRHRTPPATQAIENRRFFELARSYDIVEPLVPLLVGEKKKKKKKMQRGEGVGLMLDFGALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M3CDT0</accession>
    <name>M3CDT0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_134373</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Vacuole membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ATG22 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759292.1">
        <property type="nucleotide sequence ID" value="XM_016902635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CDT0"/>
    <dbReference type="STRING" id="692275.M3CDT0"/>
    <dbReference type="GeneID" id="27899772"/>
    <dbReference type="eggNOG" id="ENOG502QTJZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017518_2_0_1"/>
    <dbReference type="OMA" id="DGWGMVG"/>
    <dbReference type="OrthoDB" id="42657at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050495">
        <property type="entry name" value="ATG22/LtaA_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519:SF5">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="486"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF11171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="537" mass="60660" checksum="2348CCDE7F9E350D" modified="2013-05-01" version="1">MASTDPGLAQVAATAEDPIKGAIYKDDGELMEEEDRPVAPDQFDVRYETTKTEIWAWYGYYMGNNGLTLFNFAPTAAQNLLYQHAEAIGGPDNQIVHFAGSNRTINSVILLCNGISFAIQIVIFLVLGSYADFGTFRPNILIVLSLIAWGIGFGWLGVHTVDDWQIGLGLYVVGLIAYQLCLTYWTAAFPGLARNTPETREKARQYEDGEITRDEYDHADSMKRNELSNVAFIVQSVVEIFILVIIVGIMFGLDVNASVAKNNYGLSVLIAFASGVWILVALPWFFLEKRRPGQDPGMNIVIAGFWQLYRALTQIWQLRQSLMYLIGYFLLGDSLNTTVTVIATLQNEIVAYNTLQLTYLLIVGIAAQGVGILAFWFVQKRFQLSTKTMFNAVAVGIILLDGWGMIGIWTQRFGFHHKWEVWVYQVFYGLFVCPWYSYSQTMISEVTPRGKEFLFFSLFSIIGKTSSFIGPFISSAIIDDTGNNSSPFYFLFALSLASFLFLLFFVDVKQSRVEQADFLERERLLKEEKKKRKNSTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>M3CFV7</accession>
    <name>M3CFV7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="14">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SEPMUDRAFT_149293</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760814.1">
        <property type="nucleotide sequence ID" value="XM_016905468.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.M3CFV7"/>
    <dbReference type="GeneID" id="27902605"/>
    <dbReference type="eggNOG" id="KOG0054">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_27_1_1"/>
    <dbReference type="OMA" id="HYAYNIE"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18597">
        <property type="entry name" value="ABC_6TM_YOR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18606">
        <property type="entry name" value="ABC_6TM_YOR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000010">
        <property type="entry name" value="Multidrug resistance-associated ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000997">
        <property type="entry name" value="Multidrug resistance-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="391"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="824"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="865"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="936"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="960"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1049"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="159"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="490"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="826"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1142"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="766"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="102"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMF12693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1426" mass="157936" checksum="D2A8722E00CDD49E" modified="2013-05-01" version="1">MVVPKSQEKHSQHHNHLSYPPRKWYRKIPFIRDISSQTLLDENGNKRPTPEITTNLWNRLFFNWLNELIALGYSRPYAKEEIYLLPESSDSLLFGEMLDRYLARYQREIKEEGEEEEAAASQNQNEKKRKKKWFRPNFLNSPSWRLTRAINSTIFTWFWIGGLIKLLADSATICSPLLLRAIVQFLTKSEKNRKAGNPEPSLGEGMGLSIGLGALLAFGVMANVHGFYRGYTSGILLRGALINSLFRRTVEFSPLERTKYNLAASRIVSLISTDVSRIDFGLGYFWSFWTGIVQILICLGLAVSSLGPSALVGFGLIAVLVPTQSTIGKHLFVLRKRSMPFTDARLAAINQALESIRLVKVYAWEEAILSKIAEHRYDELRLLRSRLLLRAFNIALSFSVPTLAAVVAFVTYAALGNALDAAEIFSTLTLFMLLRTPLQLLPVALGAITDAASAIQRVSAVLDTPEPDSTLPIDHQLENAVELDSASFSYRIHDEMEHSNSGNEKAPPEERQTFALENLTLHVRRGELLVIVGPVGSGKSTVLGSLVGETRFEGGRAVLGSEVAYAPQRAWLKSASIRENIIFGREWDAQRYQEVLDACSLASDLAIFPEGDRTVIGEKGLSLSGGQIQRVALARTIYKPSRLLLLDDVFSALDARVQAFVFQKVVLERDPGTALVLVTHSLHLLRHADRVCCLSDGKIVEIGSFPELMQKPNGEMRRLVEDFASQSVAESQREKERIAKEEAARIAKGEAVNSGEVADTKEIDTSKPIVPDTDTVSREKPIPAPDQNNTSGKAIMQTEERFVGSVTWRTYVEYIRRGKPTVTLTLFAISVLVFQGGSILSPLWLQWWQEDKYTNIDSGVYMGVYAALGIAQAIGLLCMSASFGFFIFYSASQIHANAARSVLFAPISFFDTTPLGRIIARFSKDTDSIDNVIGEAFRMLLSTTAQVVGAVVLISMLLPWFLLAVFVILCMFIVLGMYYRPSARELRRLDALLRSPIYEHITESLAGITVIRSLGALKTTVDRNTSNINTENAPYWLSVACQRWFSVRLDLLGVCLVLLVGIIVVASRDTLSASQGGLALSYIVTVQSVFGYMIRQSSEIENNMNAIERLLFYSTQVPQEPPHTQRDDQQLASQRWPTHGAIEMEDVVFTHRKGLPPSLRGVNIAIPAGSRVALVGRTGSGKSTMLAALVRMGEVTNGKILIDGVDVSTIGLNLLRNKIAFMPQEAALLNGTLRYNLDPFGEHDDADLWRVIHQVGLAFTAANDSESSTENLTKSDDVIDEKERRYFNSGAAQHHLSLDTMIVAERGNLSSGQRALISLARALIKEASIFVFDEATAAMDMESDHHVQQVLRANLRGKTTIIVAHRLDSVIGSSDIIFVMEDGKVAQAGPPLELYREGSGLFHTLCANAGICDDDIVAAYERFHSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M3CL10</accession>
    <name>M3CL10_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ClpP/crotonase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_148170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762589.1">
        <property type="nucleotide sequence ID" value="XM_016904753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CL10"/>
    <dbReference type="STRING" id="692275.M3CL10"/>
    <dbReference type="GeneID" id="27901890"/>
    <dbReference type="eggNOG" id="KOG1680">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_2_1"/>
    <dbReference type="OMA" id="GWTETAH"/>
    <dbReference type="OrthoDB" id="2018133at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051053">
        <property type="entry name" value="ECH/Chromodomain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684:SF4">
        <property type="entry name" value="ENOYL-COA HYDRATASE_ISOMERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G01890)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF14468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="326" mass="35780" checksum="E1C31A77FFAE84F6" modified="2013-05-01" version="1">MSGSGKGSQYLESPSLHEIPIPRSYADIGFTEIKVTNVPESSTEVTPVQLVTLYRPKKYNAFTPTMMRELEHAYTLFDIDDRVKCIVQTGHGKMFCAGADLDTGFVGGEEAVRDHRDGGGRVTMAINRCRKPTIAALNGAAVGVGVTMTLPMNIRIAYKDAKIGFVFARRGLVMEAASSFFLPRLIGTSKALHLCTTGSIYPASHPLLSDLFTETLPTPDAVLPRALELADEIVKNCSGVSLHLIKELMYRGPGSPEATHLLDSRIVYELFTSKDNKEGVKAFLEKRQTNFTGTMQNDAPAAWPWWEPIAVGNKPVQKGYKFKPNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M3CLC2</accession>
    <name>M3CLC2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SIMPL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_140329</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762714.1">
        <property type="nucleotide sequence ID" value="XM_016902933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CLC2"/>
    <dbReference type="GeneID" id="27900070"/>
    <dbReference type="eggNOG" id="ENOG502SGSU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075628_3_0_1"/>
    <dbReference type="OMA" id="CRKLAVW"/>
    <dbReference type="OrthoDB" id="3335918at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.170">
        <property type="entry name" value="Protein of unknown function (DUF541), domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2970">
        <property type="entry name" value="Protein of unknown function (DUF541), domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007497">
        <property type="entry name" value="SIMPL/DUF541"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04402">
        <property type="entry name" value="SIMPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF14593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="231" mass="25338" checksum="09ADEC4B39BD4D83" modified="2013-05-01" version="1">MPSTPFQLIVTGKAEVAHLAELAIINVSVSSSGINEASVSDKVITTAKHIESLLGPLSPQDDTAKAKKAAPIAHWSKTSLSSTSHGLYHHQDPDQPPIRQYNVAISFDISFRDFQALRSFGTKLSSISHVEVQNISWILTDATLKSFETELREKAAQDALEKACDYCDVLAYKANVRPVELQEATVSRSMQQAKIGIGNGEYARTEGLRFDAQKVKMAIEVTVKFEADYDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M3CPU1</accession>
    <name>M3CPU1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_147543</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763869.1">
        <property type="nucleotide sequence ID" value="XM_016904368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CPU1"/>
    <dbReference type="STRING" id="692275.M3CPU1"/>
    <dbReference type="GeneID" id="27901505"/>
    <dbReference type="eggNOG" id="KOG0583">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_172_1_1"/>
    <dbReference type="OMA" id="CSMGDLY"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000693">
        <property type="entry name" value="Serine/threonine protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF91">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PLK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="423"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="487"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="596"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="426"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="596"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="611"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="624"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="655"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF15748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="701" mass="77975" checksum="95F6C414F51FACA8" modified="2013-05-01" version="1">MACMRDGFQQERPLDNGRYITVKPLNHGSFGMVFAAKDTVTGQDVAIKCITKSAATTNCPAAINTDEYSEELNIHSCLPAHPNIVNTVSSFQTENHTYMVLELCSNGDLYEAIRMGKGPLETEHVRDLMLQLVSAVEHLHNNGVYHRDIKPENIFLTSDAAMKLGDFGLATTETWSTEFAVGSDRYMAPEQYDAGVFGYGYCPAQADVWAIGIVLLNVLFQRNPFATPTIKDPLFDDFVRDRQSLFDVFPNMSQDTYNVLRHSLAIDPSDRSLTAVREALEAVVSFTTDDEALDDFCNDQSDLAPVATAAREPLRTPSVTSPVLPGSDSFPWSSALLRTPQKPTRQLSTIHDEDMDLFPASANNSEWQYVDADEASLTSNVDSGLGLSYKSTKSMKSMHSTTSSVKKPRSNFVGSLPISFSRPKVSSYGSKSGFSKSWSDLWDEEEEEEEEEEEEEEEAEAADEVLLDTNASVEETLVVAHPDMEHVTTAKPSTPQISYPMEEGRESVTPRQAFANLDVNSRSGTPLTVIDTTADKPPVKVLPKVKSSSILDRWAALGNFRRARQDTAPVAAASTAAATPPKMKYSDAFASFTSFGSSKKNKVQAQSQLEPEPKRQRERAPSWRQGSPQRLRSSSINGSKIWQEDNNWREHKHTPQPTRVQPMAVQQSGDAQRRLPEHNFLDHDFNDEIDIEWVGQFRMDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M3CUZ6</accession>
    <name>M3CUZ6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit SPC19</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Outer kinetochore protein SPC19</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SEPMUDRAFT_167075</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex SPC19 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF07972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756093.1">
        <property type="nucleotide sequence ID" value="XM_016908276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CUZ6"/>
    <dbReference type="STRING" id="692275.M3CUZ6"/>
    <dbReference type="GeneID" id="27905413"/>
    <dbReference type="eggNOG" id="ENOG502SDEQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112993_0_0_1"/>
    <dbReference type="OMA" id="DCCEEAH"/>
    <dbReference type="OrthoDB" id="3361333at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013251">
        <property type="entry name" value="DASH_Spc19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28262">
        <property type="entry name" value="DASH COMPLEX SUBUNIT SPC19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28262:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT SPC19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08287">
        <property type="entry name" value="DASH_Spc19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMF07972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="168" mass="19014" checksum="6520E92BDAFA4EE1" modified="2013-05-01" version="1">MDSSTQNALQGCVSSLRSSMQLLESSISILDSGVHDYPRLAKVLQTTRHFELVSEHDLTTAQSSLVSEIQPEVTNLLSRVETYLDKLERREKSLMAKADLQEGRLAQPSRKNSGSKSPATRRAALGNLEEMKMQQLRQKKERLTYAVERLELQASQRQRQLRKSMAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M3CYY3</accession>
    <name>M3CYY3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SWIB-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_150976</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF09869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757990.1">
        <property type="nucleotide sequence ID" value="XM_016906517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CYY3"/>
    <dbReference type="STRING" id="692275.M3CYY3"/>
    <dbReference type="GeneID" id="27903654"/>
    <dbReference type="eggNOG" id="KOG1946">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046065_1_1_1"/>
    <dbReference type="OMA" id="KVWQYIR"/>
    <dbReference type="OrthoDB" id="10251073at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000500">
        <property type="term" value="C:RNA polymerase I upstream activating factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001181">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10567">
        <property type="entry name" value="SWIB-MDM2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.245.10:FF:000004">
        <property type="entry name" value="Upstream activation factor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.245.10">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019835">
        <property type="entry name" value="SWIB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003121">
        <property type="entry name" value="SWIB_MDM2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13844">
        <property type="entry name" value="SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02201">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00151">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109715">
        <property type="entry name" value="DEK C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51925">
        <property type="entry name" value="SWIB_MDM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="DEK-C" evidence="7">
        <location>
            <begin position="3"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="DM2" evidence="6">
        <location>
            <begin position="190"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="64"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="120"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF09869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="275" mass="30713" checksum="1ADA33A1CA0EA1A4" modified="2013-05-01" version="1">MADALPASYGQIIDEILRTADLNTISAKRIRKELQEQVGYDLSSQKKAITDLIMNRFDKAQERQKLAETAPAPQTNGQPSHDYAESSLSPTPFANKRKVESEELSDVEDSPAPKKVKKEKKQETDEEMARRIAQELNATSARSTRGGGAKRKAMVTKAKKPKKKSSAKVNSDDDSALESGDKPVKERKGGFHKPMVLSEPLAEMLGETQLSRPQTVKQIWAYVKSRDMQDPSDKRQILCDDKMRAVFKADKVHMFTMNKLLASHLYPAEEIVPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M3CZI9</accession>
    <name>M3CZI9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_151924</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">SO2202</strain>
        </source>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="126" mass="12937" checksum="AF1BAD414793210D" modified="2013-05-01" version="1">MASTNPTEETHSLPGRNPDGTFTKGSSAAKEAGHLGGLHAHHLEESQEQNSSVSSSAGRNPDGTFTKGSEEAKHAGHIGGLHAAGKTDEKKEEVSELEVQTGRNPDGTFVKGSEAAKEAGHKGGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M3CZQ0</accession>
    <name>M3CZQ0_SPHMS</name>
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        <submittedName>
            <fullName evidence="2">Phosphoglycerate mutase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_50622</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
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            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">SO2202</strain>
        </source>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07040">
        <property type="entry name" value="HP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032653" evidence="1">
        <location>
            <begin position="17"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF10119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="170" mass="18826" checksum="B3EE76CA3A0E1C13" modified="2013-05-01" version="1">MKSFLSLLAILPLALAKPTVYLIRHGEKPSSGNGLSTQGMQRAQCLRNVFGASSSYNIEYILTQDYKKDGSRKRPYDTVYPLSQDLGLTIDHKCDRDDPDCVRDKVNGYSGSGNILICWEHDALTDIVDALGDDNAPDYPGDHFDIIWVDPPSYGAITQMYSEMCPGLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <lineage>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="OMA" id="YTITEGC"/>
    <dbReference type="OrthoDB" id="5101370at2759"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="274"/>
        </location>
    </feature>
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        <location>
            <begin position="176"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF10133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="310" mass="30934" checksum="8E7BA6B4036A06CD" modified="2013-05-01" version="1">MKVRQASAAAMAVASANAQSLSAYPYASESPVSYVTVTYDFCSSVPIETMITVTNGYTVTYCPECSKTPSAVPTPPGHTTVYTTEYLSLCSTGLVPVTHTITESCTEATPTWTPGPSHLPPGFTVTVKDCTVCSGAHPTKPVSVTITEPCDCEATSGTSLGPLPTGTPVQQIPDGQIQNPAPTGTPVQQIPDGQIQNPAPTPGSPGNTPTGPGATNPTVAPYPTTTTVKCPGPACIASTMPTGTGAVPVPADSTSSPAGGASTPVDGTTPPAGTSAITPPAYTGSASSSSHAAFGFATLAMVIGTLAFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
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        <name evidence="2" type="ORF">SEPMUDRAFT_109305</name>
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    <organism evidence="2 3">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016900777.1"/>
    </dbReference>
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    <dbReference type="STRING" id="692275.M3D150"/>
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    <dbReference type="eggNOG" id="ENOG502RS0V">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_634865_0_0_1"/>
    <dbReference type="OMA" id="CKNIICY"/>
    <dbReference type="OrthoDB" id="3924764at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF11203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="432" mass="43997" checksum="3E2BB9490CC5DBBB" modified="2013-05-01" version="1">MATLLITFGALALAQVFDDPTITPAPAPSSSNVLLFPGIDASGPCKNIICYDYINTCSIRYGTCYPACGAHARPTFAGAGPCEGGQFRSSFSKSENIATRAVDACGYKCDYRTDSCSNTFGPGCYTSCSGSPAPLFTTPVCETAAPPVRTVLVTPVPAERTIALAVPLDALNRRAPYANVTSVAPFANVTSSAPFANVTSSAPFANLTSSAPFANITSSAPFANITISAPFANVTTPASVVDVTSSAPFFEVTSSEPAESYLPDEIPEGGATIGAQLATMQSQVYGYLPVADIMDSPATEANQDPIAVATPAFTDTTTTADYESMSTTAAAISLDSQSLSSTSFSSELVSSSDVASSSSSLEALPSSGMASTSESAFSTEITSTTESASSTEITSTTESAVSTEIISTTESASSIDVASSTAATALSIPQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M3D197</accession>
    <name>M3D197_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
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    <gene>
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        <name type="common">Poplar stem canker fungus</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759379.1">
        <property type="nucleotide sequence ID" value="XM_016909835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D197"/>
    <dbReference type="STRING" id="692275.M3D197"/>
    <dbReference type="GeneID" id="27906972"/>
    <dbReference type="eggNOG" id="ENOG502RCNB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_733974_0_0_1"/>
    <dbReference type="OMA" id="ADSLNWC"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF129">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="38"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="322"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF11258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="377" mass="41589" checksum="E9819748333C3D62" modified="2013-05-01" version="1">MEATAQPTAFAVQNDTRPVLIVIVSIMLILVSLIGISLRIYSRLAILGKLFADDVLMLMGTITAIGLSASYIVGAHHGFGKHVAQITPHEVQLLRKITFACIFLYIMAQLLVKTAVLVLYYRLDQRTSMRTTVYILIFIVATQNITFFTMQSLSCISIGAATLNHCLTLGQLQLLFNVTGVIIIAIDIAIFVIPLWMLHNLELPAKQKLAGGTVFALAFLPIAAGILRCSFIWHAIDTSDMHYNLVLGGIFAQVEIHLAILCGSASSFKVLLKGVWPRCGRGDASTGFSFTGPQSRPIELPTPWPADQHKLPAISLSKTSTSTDESWSTWTPHFPGLDEEKGTSEWNNRTWPSEREVADTHIPTFADFEFPQSAYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M3D2U8</accession>
    <name>M3D2U8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">L-ornithine N(5)-monooxygenase [NAD(P)H]</fullName>
            <ecNumber evidence="4">1.14.13.196</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_150394</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-ornithine + NADH + O2 = N(5)-hydroxy-L-ornithine + NAD(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:41512"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78275"/>
            <dbReference type="EC" id="1.14.13.196"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-ornithine + NADPH + O2 = N(5)-hydroxy-L-ornithine + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:41508"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78275"/>
            <dbReference type="EC" id="1.14.13.196"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.196" evidence="4"/>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759588.1">
        <property type="nucleotide sequence ID" value="XM_016906145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D2U8"/>
    <dbReference type="GeneID" id="27903282"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020931_2_0_1"/>
    <dbReference type="OMA" id="YHGNTNY"/>
    <dbReference type="OrthoDB" id="3519933at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025700">
        <property type="entry name" value="Lys/Orn_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42802:SF1">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42802">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13434">
        <property type="entry name" value="Lys_Orn_oxgnase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF11467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="515" mass="57413" checksum="3168CBF7E9679F42" modified="2013-05-01" version="1">MMAPHAMSDMSSSTLSYTSTAITSPDEIACPVRGDRRSNLQRFDNDEVQDLVCCGFGPASLAIAVALHDSLELNNTRLATRAPRVRFLEKQHKFAWHAGMLLPGAKMQITFLKDMATLRNPRSEFTFLNYLHAKDRLVAFTNLNTFLPQRVEYEDYMRWCAEHFNNVVDYSQNVESVTAGPKNPKTGAVEYFNVHSNNSETGARQTLKAKNVVIAAGGRPRIPDTLPQHHPRIIHSSQYATHVNKMFPEGSHPKRVAVIGGGQSAAECWHDIPTRFPGAQSVLLIRGAALKPSDDSPFVNEVFNPERVDDVYGQDPETRAKGIAQDKATNYGVVRIELLEEIYAEQYTYQIQNLPEEQWPQRIMNHREVTGIRDITVDGKPAGLELQIQNNAGLYHRDKPSSTETLPVDLLIVASGYRRDAYKDMLHGVQHLMPPGATDWNVKREYAVEFAPDAVESDAGIWLQGCNENTHGLSDTLLSILAVRGGEMVENIFGYSPSANEKQMESLVLGGKVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M3D3Y3</accession>
    <name>M3D3Y3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_149235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760735.1">
        <property type="nucleotide sequence ID" value="XM_016905432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D3Y3"/>
    <dbReference type="GeneID" id="27902569"/>
    <dbReference type="eggNOG" id="ENOG502QV9J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017407_0_0_1"/>
    <dbReference type="OMA" id="IIRQHHP"/>
    <dbReference type="OrthoDB" id="5402147at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="557"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="598"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF12614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="616" mass="69285" checksum="E492C24AE6DFDBA8" modified="2013-05-01" version="1">MAFQQPQQRPRPTRHLSIDQPSQQQTPAPTSPATRRTTEESQEWILFSPQNDEYSATGTSRTPRTATHRTHSDIASLETHVRSENNPDDSGTCLGTEADELDSLDDGLHAFHHHHHQHHPFTDPSNLDQSGGTVLPTHDGFGTFPSGIDLQEHLWQFERYNPHRRSTKQHARRRSSVQRRMDEIEVEQDVTPEDERTARIEKWRLDQSKAVLEEIERETRRRRRRLSRMATGTSAAGDDVRTSLPDEALSRLLTRQDSAITIDAATDHQPPSESWWRRITRKVIKDLIGLDEATLAVIFGEQLVDDASPTPTRPSPLAARAMEESRVAFQDADPAWEVKLLDRIARELGILVHTLSEADGSAFQSYKNTQREEFEYAGLPRNTPRQLSLRQRRREEKTTRPGTAPTENAFVPTVPLSPLSSGTGPGDTSLWGIEEEPDHVIDDEEATKLQQEREYWERDLDVKMVFSYLKNRFSSAEAAEPAAPTTAAADSIGPLPASWATVPTQSAMGTSPQSQRRQEIIRQQHPLVSRAAERAVERAQAHAAHARRRETLLKKHQMEQLARKRTGHSSCASQSTKRSRHTKSGSSRHYWDIGGSTGSMHSGQAMSSALGGWGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-05-03" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M3D552</accession>
    <name>M3D552_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_125143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761436.1">
        <property type="nucleotide sequence ID" value="XM_016901957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D552"/>
    <dbReference type="GeneID" id="27899094"/>
    <dbReference type="HOGENOM" id="CLU_2980581_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF13315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="58" mass="6969" checksum="8B40F92A485B9D77" modified="2013-05-01" version="1">MVLEEEEDHEHDMASEWEDIDHDMVSEDDEDIDHDMVLEEDDIDHDMVPEEDNDRAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M3D621</accession>
    <name>M3D621_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Glutamate 5-kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_148860</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the glutamate 5-kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761741.1">
        <property type="nucleotide sequence ID" value="XM_016905189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D621"/>
    <dbReference type="STRING" id="692275.M3D621"/>
    <dbReference type="GeneID" id="27902326"/>
    <dbReference type="eggNOG" id="KOG1154">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025400_1_1_1"/>
    <dbReference type="OMA" id="NLAFPPH"/>
    <dbReference type="OrthoDB" id="409889at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004349">
        <property type="term" value="F:glutamate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04242">
        <property type="entry name" value="AAK_G5K_ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21157">
        <property type="entry name" value="PUA_G5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.130.10:FF:000008">
        <property type="entry name" value="Glutamate 5-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1160.10:FF:000020">
        <property type="entry name" value="Glutamate 5-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00456">
        <property type="entry name" value="ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041739">
        <property type="entry name" value="G5K_ProB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011529">
        <property type="entry name" value="Glu_5kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005715">
        <property type="entry name" value="Glu_5kinase/COase_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019797">
        <property type="entry name" value="Glutamate_5-kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01027">
        <property type="entry name" value="proB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43654">
        <property type="entry name" value="GLUTAMATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43654:SF3">
        <property type="entry name" value="GLUTAMATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000729">
        <property type="entry name" value="GK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00902">
        <property type="entry name" value="GLUTAMATE_5_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PUA" evidence="11">
        <location>
            <begin position="362"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="292"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="293"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="313"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF13620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="499" mass="54062" checksum="DAB50C9D2E45BA08" modified="2013-05-01" version="1">MELPSALQVNGSTIDLQKLEQGEVKGGSTLETARMKEKHLTIVIKLGTSSIVDEKTHEPLLSTLSTIVETAISLRHEGHRVVICSSGAIGMALRQMNMERRPKLLPQIQALAAIGQCKLMSMWDQLFMHMRQPVAQILLTRNDIADRSQYLNAQNTFHELLNMGVIPIVNENDTLSVQEIKFGDNDTLSAITAGMVHADYLFLMTDVDCLYDKNPRNNPDAKAIEVVEDIAELAADTSSAGSSLGTGGMSTKIVAARLATAAGVTTVITRSSNPGNITAIVRYVEAQKKTARSLEQSGELPSSPRSAAAKTPALQTTPVVNGTGSHRLEEPGLPPLHTRFLPDPHPIRDRYFWLLHGLAPHGTVYIDQGAHSALQSKTGLLPVGVVDVEGHFGQHECVRIMVLPSKGAPLSEAEDVGKAVVNYSAIEIKRIAGHRSRDIADIIGYADSDYVAVRDSVALYNKEISRPVTPMLDELKGMRIASTSDKRTSMGRLSNYVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M3D661</accession>
    <name>M3D661_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_148889</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761786.1">
        <property type="nucleotide sequence ID" value="XM_016905208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D661"/>
    <dbReference type="STRING" id="692275.M3D661"/>
    <dbReference type="GeneID" id="27902345"/>
    <dbReference type="eggNOG" id="KOG0394">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_10_6_1"/>
    <dbReference type="OMA" id="TSWKDEF"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032889">
        <property type="term" value="P:regulation of vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01862">
        <property type="entry name" value="Rab7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000086">
        <property type="entry name" value="Ras-related small GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981">
        <property type="entry name" value="RAB FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981:SF20">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB-7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF13665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="205" mass="22900" checksum="F60B7A4FCFF7DF3E" modified="2013-05-01" version="1">MSSRKKILLKVIILGDSGVGKTSLMNQYVNKKFSQSYKATIGADFLTKEVLVDDRLVTMQLWDTAGQERFQSLGVAFYRGADCCVLVYDVNNSKSFDTLDSWRDEFLIQASPMDPESFPFVVLGNKVDVEESKRMISTKRAQAFCQQKGGIPYFETSAKDAVNVEQAFEVIARNALAQEESQDFNGDFPETIPINIGENEQGCSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M3D6R8</accession>
    <name>M3D6R8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_64614</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016909684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D6R8"/>
    <dbReference type="STRING" id="692275.M3D6R8"/>
    <dbReference type="GeneID" id="27906821"/>
    <dbReference type="eggNOG" id="ENOG502T6XG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1175881_0_0_1"/>
    <dbReference type="OMA" id="PPHEIRI"/>
    <dbReference type="OrthoDB" id="417697at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF13569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="28224" checksum="D9309BB23F75EBA4" modified="2013-05-01" version="1">MELPADDNRLTEQHDIITSSLGYHIHPTIVKALNEEAGTPPHEIRIADVSQGGQFENTAILPATLLTAQRTRIHFARLLATSTIPDDLRGQFDVVAVRLLHTNLVPDRFQEALDSLIALLKPGGWLQWIDWDPMTARIATVKPGADDIVLREILSRFTEALRTRKSGSTYKISTAMQLQLECEDSDMYVVTPEVRFTKNVVATALLFLERSDACTAEEASVLRGKVKTEIENSGSLLFYDLWCHIARKPMGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M3D7N7</accession>
    <name>M3D7N7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_106556</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762321.1">
        <property type="nucleotide sequence ID" value="XM_016900642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D7N7"/>
    <dbReference type="STRING" id="692275.M3D7N7"/>
    <dbReference type="GeneID" id="27897779"/>
    <dbReference type="eggNOG" id="KOG0773">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_293410_0_0_1"/>
    <dbReference type="OMA" id="HTRCAEN"/>
    <dbReference type="OrthoDB" id="5399138at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="112"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="208"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="435"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="210"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="333"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="913"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="355"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="366"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="378"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="395"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="917"/>
            <end position="934"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF14200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1036" mass="115017" checksum="18516D4A86AE75AF" modified="2013-05-01" version="1">MYSAAVLSAMERDEAEMTTTATADEDLLHLAPIDFRELLADVTSAEAETQQNQQQCSLHSDVDNSLCNDCAGDWTQIEETEDTDAPLAAEVVEPDYSQFQNWIPEFVWPDKPCDDCRSRRLSCYVQRGEPHCTPCSTLFRECSLSKSQALEATNYAYNDLGNFLDTLHVVHEDNPRDFGTYTGTKPLRAIDCTAGTDATTTTKDVASSSSKRNGTRFPRQAVKVLRDWLGAHADNPYPSSEEKAELERRTELSPSQIANWLANARRRRKVTGKSKPKLCMSPSLTPTTRAIAIPGATEKPWDELNPFERWQHSPPENEPAGLEDIANALARNELPADDVSTSPSTLSRCKKRKGSSNGSGWSKSRALSTTSQDTGRTSSLSASSARFSNASSHSTHGSIGSFSPTLSGKKERRRRRRAAMQAPSQRTTDDRKRIFQCTFCTDTFKYKYDWTRHEKSLHLSLEKWVCMPLSPILTDIESGSSKCVYCDVHNPSNDHLDLHNHRQCEEKGVDARTFYRKDHLRQHLRLMHGCEMTPAMDSWKSIVVNISSRCGFCAQRFTVWQERVDHLTAHFKAGSRMSEWKGCRGLDPAVAAQVTNAMPPYLIGIESVSPNPFSATNRSTWRALPGSRLDVDAGNKALGTLGEDSGKHSEIMNAHCDRYGSTKATCWEILTIRLGNYAKKMAEQGMQMTDEMLQKQARMVLYDNDDTWNQTAADNPEWLDLFKKAHGLESIPNAIGGQGLNDLEGLVSLHYIDRTSTGQAFAEWQKECYGDLGLRVPFAVQLQAYNLAQTGQQMIDAGSRPGPHILASEQRQANEARIYAPISKEGVLQSGEAGCEHTRCAENVFDISSASRSQAPCPELRSRCGNDLLTDLQKRVHMLQRTEIDEASRHHNCVSPALGSIFAFDARETAQAAAAATSSRPNMSEMETTSTGAKTESLGPQAIASLPFASAASTSRVPLPNSIQDEGLDWTMLISGDMPWMNSNTMAKAQPLDTALSQETAMDDVKFDDMIFDMPLDEAFGMNQIFERVNVKYEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M3D850</accession>
    <name>M3D850_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_124336</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762165.1">
        <property type="nucleotide sequence ID" value="XM_016901906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D850"/>
    <dbReference type="GeneID" id="27899043"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_1_0_1"/>
    <dbReference type="OMA" id="FCCAVAV"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF177">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER MCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="360"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="398"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="435"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="464"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="93"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF14044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="499" mass="53861" checksum="E4EC9389D1000479" modified="2013-05-01" version="1">MSQACSRDEQDGQKLTLPLPLPRSDPRVGEKSVVKGKEEKDISSEEEEEEEDSEESSGGDNIHPSPTKSSSSSNNNISPHEEFYPEGGTRAWLVVLGSFSGMVAALGIMNTIGVYESYLARHQLASYSAASIGWILSIYVFLAFGAGLVIGPIFDVHGPRWLLFAGSILIILATFLLGVCTAYWHFILVFGILAGLGTALIFTPTIAAVGHFFYEKRGNATGVAAMGGAIGGIVFPLMLQNLFPKVGWGWATRIQGFVFVVLLVLANLLVRSRLPPRPNQSIMPDFMIFRQLNFALVTAGTFFMEWGLFVPISYVTAYSLSSGAMSTTFAYQIIAILNAGSAIGRWLPGLLADKIGRFNAMLLALSLCVLSSFCLWLPATILSSSSTSSPATHTNTIFALTITFCIIFGFASGSNISLTPVCVSMLCKTEEYGRYYATCYCVVAIGTLTGIPIAGALIEVCDGAYWGTALFTGCCYALAMVCFTAVRVRMVGWRVDVRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M3D8D0</accession>
    <name>M3D8D0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Splicing factor U2AF 35 kDa subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_115663</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762506.1">
        <property type="nucleotide sequence ID" value="XM_016901190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D8D0"/>
    <dbReference type="STRING" id="692275.M3D8D0"/>
    <dbReference type="GeneID" id="27898327"/>
    <dbReference type="eggNOG" id="KOG2202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059852_1_0_1"/>
    <dbReference type="OMA" id="MIDTRQA"/>
    <dbReference type="OrthoDB" id="423462at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000243">
        <property type="term" value="C:commitment complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089701">
        <property type="term" value="C:U2AF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000066">
        <property type="entry name" value="Splicing factor u2af 23 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009145">
        <property type="entry name" value="U2AF_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12620">
        <property type="entry name" value="U2 SNRNP AUXILIARY FACTOR, SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01848">
        <property type="entry name" value="U2AUXFACTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="9">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="44"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF14385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="209" mass="24370" checksum="88B6B08754DC9969" modified="2013-05-01" version="1">MANYLASIFGTEQDKVNCSFYYKIGACRHGDRCSRKHVKPSYSQTILLPNLYQNPAYDNKSRMNPQQLQNHFDAFYEDFWCEMCKYGEIEEVVVCDNNNDHLIGNVYARFKYEDSAQKACDALNSRWYAARPIYCELSPVTDFREACCRLNSGEGCVRGGFCNFIHRKEPGPELERELELATKKWLRERGRDERSVTRSASPEPLKPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M3D8J4</accession>
    <name>M3D8J4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heme oxygenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_162393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762335.1">
        <property type="nucleotide sequence ID" value="XM_016908002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D8J4"/>
    <dbReference type="STRING" id="692275.M3D8J4"/>
    <dbReference type="GeneID" id="27905139"/>
    <dbReference type="eggNOG" id="ENOG502QQ9D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033363_1_0_1"/>
    <dbReference type="OMA" id="WLAERYW"/>
    <dbReference type="OrthoDB" id="37730at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd19357">
        <property type="entry name" value="TenA_E_At3g16990-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053261">
        <property type="entry name" value="Polyketide-peptide_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41813">
        <property type="entry name" value="REGULATOR PAB1642, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11955)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41813:SF2">
        <property type="entry name" value="REGULATOR PAB1642, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11955)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="546"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF14214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="584" mass="63953" checksum="32D51C2127095177" modified="2013-05-01" version="1">MPRPPDNYTHAQFESVESEHQGETVQCIHCRNWTGSIKTLNRKKAHLLNCPQYAAWRAAGNGQDLAPPNKYSKRDSDLAGWQGDADHGYNHSPYGAPPPPQFSTPVMVRSRNLETSKYFDEFWDDTTGQKCMRVRCLSCGFVRAKNTTRQVEHLAVCTDFLNSTEGQQAVANGELELAQPGPSGYSNAALGPDIWRGGKPNPNLQVGGRPSMESMNPMRAPQRPQASLVNHLLNKWPEKFTKATQQQFLSHAGCGTLSATALSHWLGQNGHISRAMIAFIGNLIGKVRLPDVSNSKQSTQFRALDLLISTVSNLRKEIDFIEITKRKYGLQTDSEPPLPMTKAYLDLLIASAESRSSLLEGMVALWATEHCYYKSWQYASNFASTMPSSNYTVPSYLTGNGVNYGAGGQTPAFRTGGGGTNSNDQHVSALQEALIPNWTSREFSKFVDACRAIVDELANAETTGSGRDQLVRCEGVFQQVIFLWERIWPEVNGMGEEEGGVQDDSAAESPEVQLRPQNGNHDASGPSATNGNGNTQQESRKTEAIEIQDEDAEEEDHGNEDAPVEDINSPYGGLGAIAAANRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M3D8P3</accession>
    <name>M3D8P3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Noc2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_148195</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762621.1">
        <property type="nucleotide sequence ID" value="XM_016904767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D8P3"/>
    <dbReference type="STRING" id="692275.M3D8P3"/>
    <dbReference type="GeneID" id="27901904"/>
    <dbReference type="eggNOG" id="KOG2256">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011272_0_0_1"/>
    <dbReference type="OMA" id="GCLRYYL"/>
    <dbReference type="OrthoDB" id="10266662at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030690">
        <property type="term" value="C:Noc1p-Noc2p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030691">
        <property type="term" value="C:Noc2p-Noc3p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005343">
        <property type="entry name" value="Noc2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12687">
        <property type="entry name" value="NUCLEOLAR COMPLEX 2 AND RAD4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12687:SF4">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03715">
        <property type="entry name" value="Noc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="687"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="157"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="687"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="719"/>
            <end position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF14500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="748" mass="84203" checksum="42793BBC82C89D42" modified="2013-05-01" version="1">MPVSKSTKKFQKHHLSDILEKRKGQKKTKQQQQLKERKKKRKAEEEGKDPDKDGKPTTNGNSKPAAADALNDMTVDEFFQGGFEVPELPKKKGSKRKRNSAGDASDSDASAEQAPMQRDSEADSDSESDVGDFKEQLDRLAKDDPEFHKVLQKDEPEVFDDLDNLELSEDEQPEPKRKKQKKQDDSEDEAQGNELDMKTVKKWRAALQEQHSLRAAKEVVIAFRSAAQSSSSEAEEKEFKYSVSNPQVYHELLTTALKEISKVFEHHLPVQDAKNGKVHVPTESKKFKTLGPILRSQISGILHLLDHLSDPATLRLTLTSLLPLLPYLLSFKKLVRDVSRAVTVVWSSHSNTEATRIAAFLVMRRLTVIGDAGIRENVLKATYQALVKGSRNTTVHTMAGVNLMKNSAAELWGLAGGEGGVAYTTAFTFIRSLAMHLRSSITNNSNESYKTVYNWQYVHSLDFWGRVLAMHCTESTSPLQALIYPFVQVTLGALRLIPTATYFPLRFQLVRCLLRVSLATGTYIPLAAPLYEVLNSAEMRKPPKPTTLKPLDFNTTIRAPKSYLRTRTYQDGVAEQVQELLSEFFYIWTKNIAFPELALPVTVMLRRWLKEVNQRGKGKGGNNNTKINSAVQLLVQKLEANSKWVEEKRAKVEFAPNHRQGVDSFLKDVTEQKTPLGAYVVGQRKTREEKAKVLEESRKEEERRRAAEKNTNEGAEQSPDSEEEGDASEDEGSDEEMLDGEVEDSDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>M3D990</accession>
    <name>M3D990_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_115980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762836.1">
        <property type="nucleotide sequence ID" value="XM_016901210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D990"/>
    <dbReference type="GeneID" id="27898347"/>
    <dbReference type="HOGENOM" id="CLU_2607537_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF14715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="79" mass="8969" checksum="4B4DDE4C89EA38C8" modified="2013-05-01" version="1">MARSRILLAKAFRQLWQQCDDEIMSIRDWECIPRGFTAIRHVHMSNVGKFGLARPHESNGLVYVLAGNVTGQQQGIFPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M3D9A2</accession>
    <name>M3D9A2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_115733</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762580.1">
        <property type="nucleotide sequence ID" value="XM_016901193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D9A2"/>
    <dbReference type="STRING" id="692275.M3D9A2"/>
    <dbReference type="GeneID" id="27898330"/>
    <dbReference type="eggNOG" id="ENOG502QQNH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015737_0_0_1"/>
    <dbReference type="OMA" id="WGDYKGT"/>
    <dbReference type="OrthoDB" id="5592486at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF14459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="366" mass="41067" checksum="27F06709729B830C" modified="2013-05-01" version="1">MLTLRRIAPTPQAALGLRTTTFTALAHGQRACLHLSIRHWEQAKETQAPENVQDPRITNVEDQKKPIDEKGELIEDDFAVQKSSYEAPKHPIILAHGLLGFDELRPLGNAIPIRGIEYWYGIREALAAKNVEVITASVPPSGRIEVRAQRLAESIERQAGGKATQHGGSKMERQHRKPTNTALQGGLDARHMVSRLKPANVKVLSLTTVATPHRGSSFADYIFEQIGYTNVPKIYKVLEAFGMETGAFRQLTLKYMAESFNPRTPDLEGVKYYSYGAAFQPHFTSVFRKSHNVIEAIEGPNDGMVSVKSSKWGTYKGTLNHVSHLDLINWTNRLRWYFWQLTGKKKNFNALAFYLSIADMLAKEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M3D9C3</accession>
    <name>M3D9C3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cysteine proteinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_82768</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762600.1">
        <property type="nucleotide sequence ID" value="XM_016910317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D9C3"/>
    <dbReference type="STRING" id="692275.M3D9C3"/>
    <dbReference type="MEROPS" id="C85.008"/>
    <dbReference type="GeneID" id="27907454"/>
    <dbReference type="eggNOG" id="KOG2606">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034963_2_0_1"/>
    <dbReference type="OMA" id="YELGAHY"/>
    <dbReference type="OrthoDB" id="415023at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22762">
        <property type="entry name" value="OTU_fungi_OTU2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049771">
        <property type="entry name" value="OTU2-like_OTU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419:SF10">
        <property type="entry name" value="DEUBIQUITINASE OTUD6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OTU" evidence="2">
        <location>
            <begin position="163"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF14479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="304" mass="34129" checksum="E7686C9A34227577" modified="2013-05-01" version="1">MEELQARHKKELRDLQSRITQKKKQASKKTRKAVNDECDQLERDVKANQAREMAELHGEAPASAEPSAEELEKLTLQIDDDDDEPATATDAPEEHALDDETASTPTTAAGGGKKRNRQKDRLARRAAEQEELARQAAEEAANLPDMKTQERTRMLESMKEHKLVEKEIRADGHCLYSAIADQLEQLDIPLGSAPGDQPAVAPYKLVRAKAADYIQEHQDDFVPFLEEPLTEYVHKVRDTGEWGGQLELMALAKTYGTNISVLQDFGRVEKIEGADRKDAKTIWLGYYKHGFGLGEHYNSLRTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M3DBR3</accession>
    <name>M3DBR3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_60392</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763616.1">
        <property type="nucleotide sequence ID" value="XM_016909524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DBR3"/>
    <dbReference type="STRING" id="692275.M3DBR3"/>
    <dbReference type="GeneID" id="27906661"/>
    <dbReference type="eggNOG" id="ENOG502RN59">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008451_0_0_1"/>
    <dbReference type="OMA" id="PQSLKSW"/>
    <dbReference type="OrthoDB" id="46189at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033370">
        <property type="entry name" value="COG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31658">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31658:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="661"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF15495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="768" mass="85694" checksum="B04A0567CFE0511C" modified="2013-05-01" version="1">MASQPPDPRTLETWEDAFQYPLPVVRRLEQQLRRHIDDNRQKLRSLVGTSYRDLLGTAERIIDMDAQMQLVEFHMAHIGRQCNSRKLEKIGDNHKSVRSERRREEDVKFSRLAQTKVLQNALNVTSRIVKSGGDALVAAKILLLARLLHKSLAEGGDPPAVLESLRRQLASAKKRLLSYIARALAHTSLKKAKTINTLCAYSLLTACAPKDVLRYFLQIRFEQLELMAEVGSETSLLDMLALYSQTLLDAREVFPRRFADSLSHISTTTLLRDPDIQGVHELSLDIYERWIAEDVRHFHPWVRHDELSTASVGAATSSWEKQAQECLLQTLKDALSAQQDVHTVLQLRQKVITNYLVLSAKVHGDIQAQSLVDLREAFLEHLESLADEAASITGVLPQMQQHDAESGALNLWDVSTGDLDLGRGSAQFRDTILKRHHGRNQLIQESSIALDLWLARLHGFGEAIVTMQGMKWDEDIDLDLDDLAGDEPLQVVLSKQDPRRLERKLQKATLKSLQAVYTTLENSSNPDTDPALLIRILREVDDRRRRLAELVENIGSVKSSDTFVATLHQQLAKSVIAVPLADYTKRLHNHSRVAATLWDGSPPLPIQPSPSTFRFLKSLHQHMSDVGTDLWCPHAVQTLKTYLVDTLDDKTMLVHMTHGAAANADPNGPPVESGASGVATPTVSRERSVQQLFDVMYLRRVLMTSAHEPAGSPGLREVAGTLQTQLGADTGVDYERLEKSAEAYWKRTYLLFGLLAAAAAATAAGQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M3DBU9</accession>
    <name>M3DBU9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_38219</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763445.1">
        <property type="nucleotide sequence ID" value="XM_016908695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DBU9"/>
    <dbReference type="STRING" id="692275.M3DBU9"/>
    <dbReference type="GeneID" id="27905832"/>
    <dbReference type="eggNOG" id="ENOG502QRAT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003938_1_0_1"/>
    <dbReference type="OMA" id="DRWVMSI"/>
    <dbReference type="OrthoDB" id="5579281at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005628">
        <property type="term" value="C:prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902657">
        <property type="term" value="P:protein localization to prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040345">
        <property type="entry name" value="Mug56/Spo71"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039486">
        <property type="entry name" value="Mug56/Spo71_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057379">
        <property type="entry name" value="PH_SPO71"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28076:SF1">
        <property type="entry name" value="PROSPORE MEMBRANE ADAPTER PROTEIN SPO71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28076">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15404">
        <property type="entry name" value="PH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23207">
        <property type="entry name" value="PH_SPO71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="276"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="677"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="681"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF15324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="757" mass="86459" checksum="613FEE5DDE72DF79" modified="2013-05-01" version="1">MMKVDKMLVRTDITQQSLREDYDEKISQGVVTKSLDKWREFMVVCRSHEEEDAKAVLQLYQTRVITVSEDKKVKKKAKVQILLGNSKVRVNLYSALDKTLCLWTRDGLRTTIYYLRAASTATAVEWYTFIRSVLGHKRADTLQVNIPDLSVCLRLEDPFRAIETSSTFAEAEAGDDEALARAVNEEKGAAAAIVTRCMEMLKENSEWQDVLKVWAQDNRIGLAWKRYDRLEWLHGAVEQRMYGTIAMQRTHDLELRPKHHYPKLITQTTGPALEEPTPIEGFLIRLTSQQGKDQKLGKMLFKRLYFTTQSQYLLFMKPAKAKPPPPPRLPAQTAADGGVPSIQQISAQVPLTYDVEPYPLQDNNIAWLNSEGIISPMEVRDRDDAAAAEAERNVEMLQAADGFIDMCNVHRVRNFVDGATPADENVESGDDVDFHVQVPDTSVRQDDGTATEIDEDRIFELVMKNGLVIRLQAFNKVTRDEWLKRMRQLVAYWTARKKADMNLYKSTREQNLRELGIDERAEALVGQFAHKWEVGKSFASPTLYNMCGISGCRTVHLSGVLFRKPRKHTTFIRDQVILSHGHLLIFQDTLRSRSGKKLQHIHHDRIASINLKGCYLYSGLLTESDLLYQNQTFDSNTPGHHALPRVYLEDGWTSTDEDAMTTFVIWHANSKSWFKSSSTVDDQRKEQQQADDDRKVKTKLTRVSKLGTTGRNVVFKARSRAERDHWVLAIQVEIERLASQADEVRLVNDGNKDDEAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M3DBY0</accession>
    <name>M3DBY0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_80420</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763691.1">
        <property type="nucleotide sequence ID" value="XM_016910246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DBY0"/>
    <dbReference type="STRING" id="692275.M3DBY0"/>
    <dbReference type="GeneID" id="27907383"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_2_1_1"/>
    <dbReference type="OMA" id="EPCIQQG"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF4">
        <property type="entry name" value="CYTOCHROME P450 98A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="472"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF15570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="553" mass="62511" checksum="993809FA982DC2AC" modified="2013-05-01" version="1">MWPTFPAAVLTHPYLTFAILIPLLTLGIILVKDFTVYLHLPPGPTPIPFYGNTHQIPKTQPWLQFQKWSQIYGPIFTLWIGRKPTLVISDPQIAVDLLEKRSSKYSSRPRMVLLGEIFNNNASILTQPYGKSWSIRRKLLHQALNPRALKGYMKTQEAEASRMCWSLLQKGGEGWEKELERFTSSVVFCVAYGRRIDDLNAKVIRERFKFMGYAASLNVPGKYLTESFPILAKLPFQRWKRAVEAMGTEQGMANLRLMNVVRRDLEEKEKEKKEGGGEKYVPESLCRLVLETKKEEGIPLSDLQLSYVPASLFGAGSDTTASTLCSALLALITHPSVLQRAQTELDTVIGPHRLPTFSDEAHLPYIRALCKETLRWRPVAVLGGTPHASTEDDVYRSYRIPAHTTILSNSWAINLHGAYYPNPHRFDPGRFLSSHDVLHSKGEGVGEGIISGEKQHPSPSGHSSFGWGRRICPGAGLAENSLFIALARLLWTCDILPIPGREYDIFAYTDGFNIRPQKFECVIQQRSRLHAEVLEREVGSAREWLEGFRPFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M3DCS7</accession>
    <name>M3DCS7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetolactate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_124031</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763951.1">
        <property type="nucleotide sequence ID" value="XM_016901875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DCS7"/>
    <dbReference type="STRING" id="692275.M3DCS7"/>
    <dbReference type="GeneID" id="27899012"/>
    <dbReference type="eggNOG" id="KOG1185">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013748_4_0_1"/>
    <dbReference type="OMA" id="DMCFPGD"/>
    <dbReference type="OrthoDB" id="2867507at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006203">
        <property type="entry name" value="PRK08327.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF164">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="THIAMINE PYROPHOSPHATE ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="6">
        <location>
            <begin position="4"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="4">
        <location>
            <begin position="208"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="5">
        <location>
            <begin position="416"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF15830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="597" mass="64278" checksum="0B07F9704DB6D212" modified="2013-05-01" version="1">MYTASFAFFEALWEAGVTHCFVNLGSDHPSILEAIVKGQNEKKGAFPRIITCPNEMVALSMADGFARLTNKAQAVIIHVDVGTQGLGAAVHNASSGRAPVLIFAGLSPYTINGEYRGSRTEYIHWMQDVPDQKAIVAQYCRYTGEIKRGKNVKELVNRALSFAMSEPKGPVYLYGAREAMEEDIDPYQINQAHWTPAELGGLSARQLREVSEALVGANEPLVVTGYSGRNSAAMKALVSLADTVKGLRVLDTGGSDMCFPADHPAWLGMRFGVEESIKTADVILVLDCDVPWIPTQCRPSPDAKTFHIDVDALKQQMPVFYINAIARYRVDAETAVTQITGHINASMKDKISSQRFTDRATALQASYQSRLEKIAQQVVVSEDGNYGCPYLIRQVRDACPPDTIWAIEAVTNTPFVADQIQATLPNSWINCGGGGLGWSGGGALGIKLATDFENGGTNKGKFVCQIVGDGTYLFSVPGSVYWIAQRYNIPVLTIVLNNQGWNAPRKSMLLVHPDGEGSKVDNIALNISFAPTPDYSGIAKAASGHKAWAGIAGNAEELKRLLPEAVAAVKSGVCAVLDAHLDGPEGKYPGDKAALVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M3DDC7</accession>
    <name>M3DDC7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RmlC-like cupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_80987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763950.1">
        <property type="nucleotide sequence ID" value="XM_016910261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DDC7"/>
    <dbReference type="STRING" id="692275.M3DDC7"/>
    <dbReference type="GeneID" id="27907398"/>
    <dbReference type="eggNOG" id="ENOG502QUGY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071636_0_0_1"/>
    <dbReference type="OMA" id="FDMVPQP"/>
    <dbReference type="OrthoDB" id="2588190at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02215">
        <property type="entry name" value="cupin_QDO_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053146">
        <property type="entry name" value="QDO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36440">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_8G07350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36440:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_8G07350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="1">
        <location>
            <begin position="60"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF15829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="348" mass="37928" checksum="19676E6AA23FB521" modified="2013-05-01" version="1">MASTQRAPGVPGKPYVISSQEGESIYIPLSKSATRLLVTGKETDNAFAVIGSSGSQGDPVGFHYHKHTHDIFICLKGNVNVWANDEARTMSPGDFASVPPNVVHQYQLTGNHSEMLGLIVPGGWEEFFRFIGESYGGPLWPLDDERNPLEVLVPKLKAASEQFDMTPVHDKKEFDPQPWKGTEHALPGKLEPYFLKHGTGPAYAAGGALVRPLITTAESDGKFVIATIEGVSHHSKQDVFASGRKLKFAETHHAFQITEGHVEFQVGSSPPSHLHAGELVYVPKATPFSYHIRSRYAKLYAFASGKGLAELLIKAGEKHGLPTPPEKASEVKTEHLHSLASEFGHEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1QD79</accession>
    <name>N1QD79_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_144070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757332.1">
        <property type="nucleotide sequence ID" value="XM_016903064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QD79"/>
    <dbReference type="STRING" id="692275.N1QD79"/>
    <dbReference type="GeneID" id="27900201"/>
    <dbReference type="eggNOG" id="KOG1014">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_17_0_1"/>
    <dbReference type="OMA" id="FAGAKHG"/>
    <dbReference type="OrthoDB" id="5399006at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43431">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G14000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43431:SF7">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G14000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF09211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="270" mass="28808" checksum="DB603D246378BC84" modified="2013-06-26" version="1">MSSTTTTTKKAIAIIAGVGPGTGAAVSRRFAQSYPVVLLARNPTNYQPYVEEINSAGGKAMGIATDLSSAESVSKAFREIEAEFGGGEGSQNKVTVAAAVYNASGRFVRKPFLELGVEEFMEGWDVSVKGAIIFSQQVLPLLLSHNQTSPSSDPASNLKSGNYPPTLIFTGATASIKANALMSGFACPKFAMRALSTSLAKEFAPKGVHVAHAIIDGVIDIPRTKEWLKDQPAEAKIGAEDIAEAYWGLHVQSKRGFTNEIDIRPMLEKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDD5</accession>
    <name>N1QDD5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_158572</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QDD5"/>
    <dbReference type="STRING" id="692275.N1QDD5"/>
    <dbReference type="GeneID" id="27904934"/>
    <dbReference type="HOGENOM" id="CLU_557979_0_0_1"/>
    <dbReference type="OrthoDB" id="3638117at2759"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013288680" evidence="2">
        <location>
            <begin position="16"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF09365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="489" mass="53000" checksum="2A944A5939CBEF77" modified="2013-06-26" version="1">MRSSFIATLFVGALASPALNRAEQKVLGEQQQQPSFCNEAKALIAQDSQAATAYCSAYLSLPVITVQKTISRVTKTFTKITSTKTYLDYPVTTKVAKTITHSSTVFGRATTTITTTTSTETYTNPLSTCPIARQNDCSSKLNNNNNNKNSLRSSRPACLSKYISPPQISQACSCLSLSLSSTTTTFHQHPTGHPTGQGETAVLLPLPTQTITLLTAAKITRTLTRTLTTGTVTLTPTHDGFSSSTKTMYAAATETLILDGPFRLASGKDYDFLSSSSSSSSSRKGNGVEWVHVNSTAMRESRSKNDGKAMWRADDEEECLSTTTPPTWFALNGQTLVTQNFGNENQFPRYELIGNVKIVPGEGVAGVYFSLPDSSSSSSRSNHDDDKEKNGEFGVEGVEGKRVPLSCSFGRKKGWNHSHEEEEEEAEINLHEACPLTCRYVGGAGSRNSKREGGQWFVGYGGGDGKDGEEEEEYESFTMYAYRYGGLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDI6</accession>
    <name>N1QDI6_SPHMS</name>
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        <recommendedName>
            <fullName evidence="1">Pyridoxamine 5'-phosphate oxidase Alr4036 family FMN-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">SEPMUDRAFT_151484</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016906847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QDI6"/>
    <dbReference type="STRING" id="692275.N1QDI6"/>
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    <dbReference type="eggNOG" id="ENOG502S535">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OMA" id="DCPTFTT"/>
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    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR024624">
        <property type="entry name" value="Pyridox_Oxase_Alr4036_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
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        <property type="entry name" value="AGL049CP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PYRIDOXAMINE 5'-PHOSPHATE OXIDASE ALR4036 FAMILY FMN-BINDING DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF12766">
        <property type="entry name" value="Pyridox_oxase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase Alr4036 family FMN-binding" evidence="1">
        <location>
            <begin position="15"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="291" mass="32836" checksum="5AB6FAB2944BA16E" modified="2013-06-26" version="1">MTTTANPNSPPTSEAPWKKLFSSHLSKMDSPEFVFSSLTPASRSEARDGKTPVPYVPRARFCIFRSFWAELPENKHNTAEKNERVYESDLPSFTTDVRMQKTFEIFASSAGKADDESLVQGSGGGGPCEAVWWVNLPDKGIKMQWRFKGEAYIVASQDIDEGGEAQTSGVKHVKSELSRRMRVVKESGVDGWSWKKEVRAHFGNMSPGMRGSFQNPPPGQPVDKPYDEQKHQIGEKVEDLDHPVARENFRVVVIKPEEVESVDLSDPKEGRREVYKFNQQDGSWSHQTCWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDM2</accession>
    <name>N1QDM2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribonuclease H1 small subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_111034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_016900892.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR013924">
        <property type="entry name" value="RNase_H2_suC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47204">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT C"/>
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    <dbReference type="Pfam" id="PF08615">
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    </dbReference>
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        <location>
            <begin position="26"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="164" mass="18673" checksum="D632A61BBD5A993F" modified="2013-06-26" version="1">MLALQPSSSSKQPALIPNLLPCKIAHSGPIPTSQRHWNPLPTRSPKHHSDSHEVHFRGRKLRSKQLKLPENYTGVVAQKTERRLLPQQQEGQPQGRRNEIEEDQDEEDDDIQLPIEVKILETNGTFDQVVIWAHEAVPEGEDVYVKGIEEWIGFAESVGHPFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDY2</accession>
    <name>N1QDY2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_127159</name>
    </gene>
    <organism evidence="1 2">
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        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016902129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QDY2"/>
    <dbReference type="STRING" id="692275.N1QDY2"/>
    <dbReference type="GeneID" id="27899266"/>
    <dbReference type="eggNOG" id="ENOG502SSR5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1184810_0_0_1"/>
    <dbReference type="OMA" id="EHWSWDV"/>
    <dbReference type="OrthoDB" id="3800738at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF10436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="219" mass="24664" checksum="ADA73BC55C5FFB6F" modified="2013-06-26" version="1">MTTSTTPPSAVKRVFETVELLETVLVQLSSKDLLLSQRTARCFHATTQGSITLRRKLFLEPDLKLEGRLFNSHETSHGSVKRPSCKPENNRLLLRAFPGCYPTITLVIMSDSTGVRAGHDTSSPDADSGERKRRNEHWSWDVCISFPADDKPSVPEAVEYPEASWRQMYLCQPPCADLYLVRRWQKGLKPAIIRDGGIKMGDFVEEATKAVPECDGRTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1QEG7</accession>
    <name>N1QEG7_SPHMS</name>
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        <submittedName>
            <fullName evidence="3">Glycoside hydrolase family 43 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_70314</name>
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    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016909900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QEG7"/>
    <dbReference type="STRING" id="692275.N1QEG7"/>
    <dbReference type="GeneID" id="27907037"/>
    <dbReference type="eggNOG" id="ENOG502SJRA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010779_0_0_1"/>
    <dbReference type="OMA" id="KYWIIGT"/>
    <dbReference type="OrthoDB" id="19657at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08983">
        <property type="entry name" value="GH43_Bt3655-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050727">
        <property type="entry name" value="GH43_arabinanases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301">
        <property type="entry name" value="ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301:SF3">
        <property type="entry name" value="ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109791" evidence="2">
        <location>
            <begin position="24"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF10826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="378" mass="42975" checksum="5DA3278A4BB3BC42" modified="2013-06-26" version="1">MLISPSLLAAAITISTFVTASYANPTTASPDHHHHQKQQKQRQRHSADTYVGYFGTFFPVQDEAIYGWLSNGNNPHSWRQINGPAGNGSLLRSNVSTKGVRDSHLVRSRDGSKFWLIATDLNVNSFNEDFDEATRFGSRSMVVWETTSPDDLGQWTPGRLTDPLVGVDAGNVWAPEAEWDESVGAYVVVFASRFWDPEDVERTGPQPPNQLMYVLTQDFQTFSEARVYEFQGTPVIDATFYHASEEEEEGKEMNVWYRWIKEEVTYTIYQERSETGILGQFSRVGGAPLDERITFASQYENNEGPLIFHDNRHRGLYHLWIDENTLQSYIPATARTLDDMQAWEPQSLNGFPKGIKHGSVIPVTQAQYDALEERYDFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>N1QEI2</accession>
    <name>N1QEI2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_110053</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758916.1">
        <property type="nucleotide sequence ID" value="XM_016900821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QEI2"/>
    <dbReference type="GeneID" id="27897958"/>
    <dbReference type="HOGENOM" id="CLU_2039523_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF10795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="121" mass="13211" checksum="BB45B94E08F9245C" modified="2013-06-26" version="1">MGLPPAAVIVIALVSSGAAVLIAFALSSSYMKARRAEDDQNRLEMQSDQRGYMNDVRDRNKQIMMMENGYGVYRGGGGQNTHSSYLNSNAAMRYEGQREAGVVRPEMQARTETEGSSDVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1QEL9</accession>
    <name>N1QEL9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_110149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759032.1">
        <property type="nucleotide sequence ID" value="XM_016900829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QEL9"/>
    <dbReference type="GeneID" id="27897966"/>
    <dbReference type="HOGENOM" id="CLU_752641_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="354"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF10911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="368" mass="42148" checksum="822360E242BEB4B3" modified="2013-06-26" version="1">MADTTEPHTEELRNMASPEEEEEEEEEEEEEEEEEEEEEEVREEEEEVREEEGGDRKKPKPLSAAQIDYAIKQFDWTNQKIDRAMGPGTDDYYHHRHHQKCTNNSLSSFFFRSAPEVTWSDIIAHQVPRSLAISSSSSSPSSSSSSSSPVTTDNNSRETPSSQQVLCSLCLQPTITRYYRPCVFLRQVRLRAVFRCSNPTCANRFWGGMRKGKGSVGFEGMEEGMEEGMEKMGEKMGKKMEEVGEEKRGECVEQGEKKEEEEGGNDDDDVKVEVKEVEEEEEEEEKKETEEEEEEVEETGENEKKEEVEETGGNEKKETEEEEEVEETDENEKKKTDEEEDDEARASSLAKSFEVMSLEVSSTSLVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFP9</accession>
    <name>N1QFP9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphoglycerate mutase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_49010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758693.1">
        <property type="nucleotide sequence ID" value="XM_016909094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QFP9"/>
    <dbReference type="STRING" id="692275.N1QFP9"/>
    <dbReference type="GeneID" id="27906231"/>
    <dbReference type="eggNOG" id="KOG1382">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020880_3_1_1"/>
    <dbReference type="OMA" id="FPWVNAS"/>
    <dbReference type="OrthoDB" id="6509975at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000065">
        <property type="entry name" value="Similar to histidine acid phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016274">
        <property type="entry name" value="Histidine_acid_Pase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF14">
        <property type="entry name" value="ACID PHOSPHATASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000894">
        <property type="entry name" value="Acid_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="43"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="229"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="393"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF10572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="452" mass="50671" checksum="17B170F95BAB4704" modified="2013-06-26" version="1">MASSQQQPLYSEYSFDPLEHLAGIAPYFEPNDPAKDPHPPQGCEVTKVAYLVRHAAINANDFDYESYLEPFTDKLKNTTVDWSKIPELSFLSTWTPPQLEEQELVTRSGKLEAAQLGVQMSFRYPKLRLPKRVWASTAERTVVSASGLIRGLEMDDNQINLVQIYEGEESGANSLTPYKACPAYSSSRGSSQSQAYSKKYTAPILARLKSYAPNFNWTMSDVIGMQQWCGYDTVVRGSSPFCSTTLFRPDEWLQFEYSQDLMYHHNTGYGNELSGTLGYGWVNATQQLLASEDADDQDIYVSFTHRELPPTVIVALGLFNNSELTGANDVNATMPTDRINYHRQWVSSYILPFLTNIAVERMNCTGSYGYQNQSDPTYYRVLVNRSPQVLPDCFDGPLESCSAAGFKSFVQERGEMFGDFAGACGVEYSNSTNVMSFYSSPNNGTMVGKKHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1QG17</accession>
    <name>N1QG17_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_67930</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760353.1">
        <property type="nucleotide sequence ID" value="XM_016909798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QG17"/>
    <dbReference type="STRING" id="692275.N1QG17"/>
    <dbReference type="GeneID" id="27906935"/>
    <dbReference type="eggNOG" id="ENOG502RQI2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029376_1_0_1"/>
    <dbReference type="OMA" id="KTILQVY"/>
    <dbReference type="OrthoDB" id="77989at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="22"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="111"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="142"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF12232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="502" mass="53955" checksum="D630798A37D0994E" modified="2013-06-26" version="1">MAPSREPNPLRPYYIPPSIGPSPAAAAAAASSTPPSQASAIHATSRLNDTSSFSTSARDLFPDIDISSTTSEAWSHTRSLFDTLAWRYTSIVLAQPFDVAKTLLQVSLPQSQQSLGVAQKKRTTTGQSTTTSRGRGGNPYETETDGDTTEDSDDEENGIPDYFSATAPRSRSPRRRKRTPPSDSADLSPTPRPRNRTQPGLGSDDMSLRIKKPDSVMQAVSALYNTSGAVGLWRANNTTFLYSILLRTTDSFIRGLLLAILGLPDIVGPEQGGLAPGLTMSGGAGFSGIDLSDSPNPLGSLLVIGLASCLTGLLLAPLDLVRTRLIVTPISEGKRGLVSNLKRLPSFFAPASLWTPTALYHLIPNVFSAATPLFLRRQLRIAPELTPSLWSLASFSTTLTELFIRLPLETLVRRAQVQHLKQADPEMKMIVEPASYSGVWGTVYGIMYTEGETTTKAKNGMLRTRRGQGVAGLVRGWRVGFWGLVGVWGAGALGPGDKGREF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>N1QG30</accession>
    <name>N1QG30_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_119255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758848.1">
        <property type="nucleotide sequence ID" value="XM_016901493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QG30"/>
    <dbReference type="GeneID" id="27898630"/>
    <dbReference type="HOGENOM" id="CLU_855727_0_0_1"/>
    <dbReference type="OrthoDB" id="3639706at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF10727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="325" mass="36724" checksum="F3E1FF9783038800" modified="2013-06-26" version="1">MNKNKGNLATGKRQKGQTTSHRKRAEDLVVTHLQPPMLKNVDMRKLALNLPCRQLIKKRFTNLPTPAGLFSQLGSGLRLRIFALASTYSAPFRIHSFRGNGKLAHGPYHKNNLTQVADARALSAVSRAVRHETNMMFYRVNTFNINHDPHRSGNDATSVLKRFRETIGEEAFSRIRALGFIAYVSNERASQMLPPPQDLCIQITEALKAMIIAGGIYSLEIQSVSAKLEVCIAIDGHHSHRNVPIDDNDLVRALEYKTRFMTSIELSLRLAAYTWERHLARWMKMADEAAQNGDEVKRRGISEVVVSMSTARERLRTMLPLQSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1QH58</accession>
    <name>N1QH58_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_51909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757465.1">
        <property type="nucleotide sequence ID" value="XM_016909208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QH58"/>
    <dbReference type="GeneID" id="27906345"/>
    <dbReference type="HOGENOM" id="CLU_2948364_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="55" mass="6496" checksum="6E88CEC7227E3AE1" modified="2013-06-26" version="1" fragment="single">QRVEYLIDLTKLFIAAIAVIRITKGPTIYLVLIYYNKLFDILEEAIKRLKNKRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>N1QHA6</accession>
    <name>N1QHA6_SPHMS</name>
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        <recommendedName>
            <fullName evidence="5 12">Vacuolar protein sorting-associated protein 27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SEPMUDRAFT_145790</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 12">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Endosome membrane</location>
            <topology evidence="2 12">Peripheral membrane protein</topology>
            <orientation evidence="2 12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the VPS27 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764691.1">
        <property type="nucleotide sequence ID" value="XM_016903271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QHA6"/>
    <dbReference type="STRING" id="692275.N1QHA6"/>
    <dbReference type="GeneID" id="27900408"/>
    <dbReference type="eggNOG" id="KOG1818">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011862_1_0_1"/>
    <dbReference type="OMA" id="DQQCSAK"/>
    <dbReference type="OrthoDB" id="957735at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033565">
        <property type="term" value="C:ESCRT-0 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15735">
        <property type="entry name" value="FYVE_spVPS27p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21385">
        <property type="entry name" value="GAT_Vps27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16979">
        <property type="entry name" value="VHS_Vps27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1940:FF:000001">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000031">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000161">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017073">
        <property type="entry name" value="HGS/VPS27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049425">
        <property type="entry name" value="Vps27_GAT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47794">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47794:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02809">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21356">
        <property type="entry name" value="Vps27_GAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036956">
        <property type="entry name" value="Hrs_Vps27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0967">Endosome</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="VHS" evidence="16">
        <location>
            <begin position="26"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="15">
        <location>
            <begin position="173"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="235"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="301"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="362"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="522"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="238"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="250"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="310"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="363"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="376"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="543"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="570"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="616"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="665"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR036956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMF16570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="674" mass="74704" checksum="F407161A856B1E59" modified="2013-06-26" version="1">MSSWFGNTANAELDAQIERATASSLEDIALNLEISDVIRSKTVQPREAMRSLKRRIGHKNPNVQLAALSLTDTCVKNGGSHFLAEIASREFVDYLTSILRAGSSTAPALSPPNTDVQARILELLQHWAAAAQHRDSLTYLSETYRTLQHEGFHFPPRHEVASSMFDSSAPPEWADSDVCMRCRERFTFTNRKHHCRNCGNVFCGTCSSKSLPLPHLGIVQPVRVDDGCYAKLSDKARATTAPPRSSSASKRTLWQTSGMSGTESALGGGTDRMQPRDARVTDDSFDADLKRALEMSLEDSKGHAGAGYVPQTQTQSLPQRQSSALGMNGKSTSRVTPSYEAPKDEEEDADLKAAIAASLQDMETQKTRHARELKEQASSSSAPLQYQPNNQFELTPVEAENINLFATLVDRLQHQPPGTILREPQIQELYESIGTLRPKLARTYGETMSKHDTLLDLHSKLATVVRYYDRMLEERMANAYNSSRYGAVQQRQTMYPHLAPQSGVEGYYLASHPAIDEPAHQGVYSERQQHSAPYPSFDGSRISSYEPNPPESSYYPAMQHPYQPRVPSVPTEQLSSPPQQPNVHHGQSNSISQVSESAASYYTGGDQYPEAPMQSPPASSQQQQLQQRIPPPALQRQSSQSYYQTQTPLPQQQPVFPSAPQHALPVKEESLIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1QI35</accession>
    <name>N1QI35_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_72488</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757745.1">
        <property type="nucleotide sequence ID" value="XM_016909994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QI35"/>
    <dbReference type="GeneID" id="27907131"/>
    <dbReference type="eggNOG" id="ENOG502RY0X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1251359_0_0_1"/>
    <dbReference type="OMA" id="WIASKAA"/>
    <dbReference type="OrthoDB" id="3210850at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38848">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 3 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38848:SF3">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 3 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF09624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="221" mass="24219" checksum="D4DAB289680D82A1" modified="2013-06-26" version="1">MAGLTLWIASKAAAFLFLIERAYIISWPITPRHKTPDYVLSYIVIFSAYFTVTVLSIKFRVAFVLEPADICIIGIQMYALIPLLLVEVLSYLYLTIRFLIPLVMVHFGGQGLLVPLRKVVIRTCIGTVIAMLSTAAVKISLTLFNGEPAWLCCMTCKIDALIACTTLHWITKPEATEGGENGTPQTLGVGFDENDKESGVVVETSQVSDNQRAASNSTTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>N1QI68</accession>
    <name>N1QI68_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_120502</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757785.1">
        <property type="nucleotide sequence ID" value="XM_016901611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QI68"/>
    <dbReference type="GeneID" id="27898748"/>
    <dbReference type="HOGENOM" id="CLU_1994040_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF09664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="143" mass="16676" checksum="C7689755AFC3913A" modified="2013-06-26" version="1">MPKRKSNALEALANKRAKLGAASKSLEEYSLKPNTLRDRERTAAIDEEKRVQDRYRKARNESFARFKKAQIKEYTSFESLAKDEQQELIEGWRKIHTKEYDQKATKKQTGKSAILPPNEQAKINKADWFLELGDIDSKERLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJ09</accession>
    <name>N1QJ09_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_112332</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764393.1">
        <property type="nucleotide sequence ID" value="XM_016900971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJ09"/>
    <dbReference type="STRING" id="692275.N1QJ09"/>
    <dbReference type="GeneID" id="27898108"/>
    <dbReference type="eggNOG" id="ENOG502T2Z7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_665619_0_0_1"/>
    <dbReference type="OMA" id="WTLIWIQ"/>
    <dbReference type="OrthoDB" id="3934549at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="41"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="279"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="282"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF16272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="415" mass="45687" checksum="FF8402553633E82B" modified="2013-06-26" version="1">MALNITQILSTLSSAPNTTQGPTLLLIIWLLLSLSTLTVLLRCLIKLFLTHKLFLDDILMICAVLFALVHASLIHVAVQNGFGKHIIYVGWEKLPMCMKVGSLTTSPSATLRKIWPRIIWTAIIMQVVVNGVGIILFYCQCGKDLDVFWTLAKQIRYDEFCWDPVIQTNYGYFMGILNTLTDVWLAILPAVLVHRTKMRLRRKIGVAGLLCLGLWASVASGVKTVEAGNLSKVTDYTYTLSTYVIAMAVELNIVIITASIPCLRPLFRKSLWKKLLRKRHSSSSNPSRSATPASITRPGRRGGGGGGRRSLSGLPSLHQLPPWRTKHIPLSSGFTSKNGSGTNLTAVTSNTNQGEDTELSCVEGWCDGDVREVDGVITVTTEVEISYQSMEKPFVHASIVGLIQGEIANPRLRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJ71</accession>
    <name>N1QJ71_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_127289</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758740.1">
        <property type="nucleotide sequence ID" value="XM_016902142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJ71"/>
    <dbReference type="STRING" id="692275.N1QJ71"/>
    <dbReference type="GeneID" id="27899279"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020492_1_0_1"/>
    <dbReference type="OMA" id="VMKATCD"/>
    <dbReference type="OrthoDB" id="10029320at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11051">
        <property type="entry name" value="CYP59-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF107">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="396"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF10619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="472" mass="53100" checksum="2C0C5C0B845733EF" modified="2013-06-26" version="1">MGDVLFFDPWPLGPPLMAIFNVEMLNQVIDGNYPKHPLVKEFIANFGGPANLVSEDGPVWKRWRTAFNPGFSSSHLMTQVPAIIKEAKVFCEIMAQHAEKNDLFRMEIATTKLTVNVIGRIVLDVDLNAQLGSNVLVDAFNSQVRWQARGAQFQPSELWDIRRPIIQRYNNWKMDRYVGARLDERFAGRQSRGRSKHVIDLALETYLKEIKGGGGKDSGDDDKQQTQLDPEFKEAAISNVKTMLFAGHDTTSSTICYAYYYLSQNPSTLAKIQAEHTAVFGPDPTTVAASIIHDPHLLHKLEYTSAVIKEVLRLDSPASTIRLGKAGHTLYHPETGEKFPTEHFMLWPVNVGLHRNPKYWPDPDHFDPERFVVGSAVYHENNKEAWVPFSKGSRNCIGQELAIIETKIILAMTLRTFDFRAAYDELALLKGDGTGYPSDDSGVQTQFGDRAYQIQLGTAKPAEGMPCRLRFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJL1</accession>
    <name>N1QJL1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Catalase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_90079</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the catalase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758845.1">
        <property type="nucleotide sequence ID" value="XM_016910519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJL1"/>
    <dbReference type="STRING" id="692275.N1QJL1"/>
    <dbReference type="GeneID" id="27907656"/>
    <dbReference type="eggNOG" id="KOG0047">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010645_2_0_1"/>
    <dbReference type="OMA" id="YNTSFCT"/>
    <dbReference type="OrthoDB" id="6880011at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024711">
        <property type="entry name" value="Catalase_clade1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465:SF9">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038928">
        <property type="entry name" value="Catalase_clade1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110890" evidence="10">
        <location>
            <begin position="18"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Catalase core" evidence="11">
        <location>
            <begin position="61"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="389"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF10724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="530" mass="59655" checksum="55190B2850CF2BEA" modified="2013-06-26" version="1" fragment="single">MRLTSFALLATPLLADAQSYSILRKVTQPPQNRVDYKTDLFEGTNLKQEQSVLNNSDLTYTDRNGKKNWQPLGAQRAGEKGPLLLQDVALIDTLATFNRERIPERIVHARGAGAHGFFEATTDYASQFSAASVFEKGTRTSVTMRFSTVGGARGSADTARDPRGFSIKFRTKEGILDWVFNNTPVFFIRDPAKFPRFIHTQKTDPARNVRDWNTFWSWPAQFPESLLQFLRLFSDLGTPYGFRHMDGWSGHTYKLVKPDGSWVYTRVYLSTDQGVRNMTADEAAKHAGENDAWATDDLYNNIQSGNYPSWTVGIATMTPEQAEAYRYDILDLTKDWLGVEYHEIGRITLTQNPENYHAEIEQSHFSPANMVPGWEPSNDPVLQSRLFAYNDAGRYRVGVNAEEIPVNCPFSSVANFDRDGHLSSHGNQGGRLNFPAEILDPIHIIDRPGTAIDHPLEGASTVQWLSEIDENIDYEQPRLFYEGFSQTDKDHLYSNIAGTLVNVDHQPVLDALFEQFGKISPALLTGVQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJN3</accession>
    <name>N1QJN3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF1772-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_145732</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the anthrone oxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764618.1">
        <property type="nucleotide sequence ID" value="XM_016903233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJN3"/>
    <dbReference type="STRING" id="692275.N1QJN3"/>
    <dbReference type="GeneID" id="27900370"/>
    <dbReference type="eggNOG" id="ENOG502SF5R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105974_2_1_1"/>
    <dbReference type="OMA" id="LAWCASD"/>
    <dbReference type="OrthoDB" id="5954308at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013901">
        <property type="entry name" value="Anthrone_oxy"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35042">
        <property type="entry name" value="ANTHRONE OXYGENASE ENCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35042:SF1">
        <property type="entry name" value="DUF1772-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08592">
        <property type="entry name" value="Anthrone_oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF16497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="194" mass="20860" checksum="067084F49343D330" modified="2013-06-26" version="1">MTTRPFYTDDLPAGLRTAQVLGLTASAFLAGKTFSASFSAVPALMRAESPSLLAKQWKTLYDSDKLVAPLISVFSSGIFAFLAYRDETWTKPAIMYTTSSSLLLSLLPFTFLLGEPINKKLEEKARTLTSADVREKSVGEDSVHGLVDKWATVNLARAVISAVGAVTAIWAAVERTDIVPATVRIGTGANRMGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJN8</accession>
    <name>N1QJN8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable endonuclease LCL3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Probable endonuclease lcl3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SEPMUDRAFT_150765</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LCL3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758880.1">
        <property type="nucleotide sequence ID" value="XM_016906382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJN8"/>
    <dbReference type="STRING" id="692275.N1QJN8"/>
    <dbReference type="GeneID" id="27903519"/>
    <dbReference type="eggNOG" id="ENOG502S1U4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046484_0_1_1"/>
    <dbReference type="OMA" id="IYHTPGG"/>
    <dbReference type="OrthoDB" id="430293at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000029">
        <property type="entry name" value="Probable endonuclease lcl3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302">
        <property type="entry name" value="EBNA2 BINDING PROTEIN P100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00318">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="Staphylococcal nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50830">
        <property type="entry name" value="TNASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="17">
        <location>
            <begin position="75"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="241"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMF10759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="266" mass="30303" checksum="C92D5C3AEC56A3D3" modified="2013-06-26" version="1">MGWFWSGWQQQPSETGTRTHTTPSPAHGGSHQQLNTVAWCLVTAVVVTGGPLIYKRHLRRVRNVDYLTPRQFRTKTLFGHVTRVGDGDNFRFYHTPGGRLAGWGWLRSIPTKAGDLKDETLHVRIAGIDAPELPHFGRPGQPHGQDAIEWLNNQLLDRRVRIRPLSKDQYGRVVGTVRMPYRLWNRDPGMQMIKAGWATVYDAKSGAEYGGQEQEYRDAEARAKKRRVGMWGGQNMIGKLLGKKQEPLESPREFKARTKKEEISPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJS5</accession>
    <name>N1QJS5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA (cytosine-5-)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_55966</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="1"/>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764653.1">
        <property type="nucleotide sequence ID" value="XM_016909384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJS5"/>
    <dbReference type="STRING" id="692275.N1QJS5"/>
    <dbReference type="GeneID" id="27906521"/>
    <dbReference type="eggNOG" id="ENOG502RYYW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012943_2_2_1"/>
    <dbReference type="OMA" id="CCYWSPA"/>
    <dbReference type="OrthoDB" id="414133at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044027">
        <property type="term" value="P:negative regulation of gene expression via chromosomal CpG island methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.120.10">
        <property type="entry name" value="DNA Methylase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050390">
        <property type="entry name" value="C5-Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10629">
        <property type="entry name" value="CYTOSINE-SPECIFIC METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10629:SF52">
        <property type="entry name" value="DNA (CYTOSINE-5)-METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00105">
        <property type="entry name" value="C5METTRFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF16532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="636" mass="72109" checksum="68E169DCAA187592" modified="2013-06-26" version="1">MDDEDIPLPTPEDFEEEDSDLLEVEIITRQEFENHTRYAAGNELPFNHEIAPYAPLLGNGRLEAGEDVELIDGDFLRVTHIVRDKALPRADPLAYILRGILLRRQRSLDNMFSRTTNELAAIILVPMDDNRPHFVSGLEDRPLTSFVCIREIVFTNAIFPQFSFRNLEGAARKFFRMPCGDGPLAMTYLKKDKAVEEARLVCRMKVVKRYIMDGKREKLVSNAFRRLLPDEADPKYRKSPVELFREWREGWREQTDRPKAAAASRKASDLSITPASSRKRSADVIILDDSDDDRLSSAKPPQTPILKTYSLFDFFCGSGGVSEAARLAGLNVKYAIDNQKCAVRTHQKNHRRCTTMHNDVADFIAMVKPGAIQVDVIHSSNPCRYWSFNHTIAGKDDEMNEAIAYTAEEAGKKFRPRIFTFEQTPGLCGIEKHRANWQLFMRQLTSVGYDVEWRVISFADYGNPQARKRLIIFAACPGQQLPEFPCPTHGKPGTGLRGYKTVNETIGNMPRGITFHNPDVMREKHRNKPYNMPPAPGHLPLSHLVDRAGPHALHPNGKRQFTLREVLRLQGFPDTYQYASDTPGKPITHRQGLKMAGDAVPPKAFKPFMEECKKALEKTDKAIAEYVPPPPIVIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJY2</accession>
    <name>N1QJY2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_145809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764708.1">
        <property type="nucleotide sequence ID" value="XM_016903282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJY2"/>
    <dbReference type="STRING" id="692275.N1QJY2"/>
    <dbReference type="GeneID" id="27900419"/>
    <dbReference type="eggNOG" id="ENOG502QRJE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017366_2_1_1"/>
    <dbReference type="OMA" id="ATWHYGS"/>
    <dbReference type="OrthoDB" id="10261782at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038921">
        <property type="entry name" value="YOR389W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35204:SF1">
        <property type="entry name" value="ENTEROTOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35204">
        <property type="entry name" value="YALI0A21131P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF16587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="546" mass="61271" checksum="50528FFFAE66926B" modified="2013-06-26" version="1">MAYAILGGLSDSHLLTFRTTRPVNVVYFDGTSAALTDNGSMDTQMLLLYNNSANVPDNPIWPRPPPRRPNETTPYPPPRWGYGRPPPGFNPLQGEYDRADGLCRFIRESSLGGPGWGFEGVVRMNAAFELIWCNFTSPSAQLVSWLNVSAPFLAGVAPGPYWRHMNTAFRGRSAYEWFLAAARTYGFTRGMPGMGESRVKIDSCGLFSFYDGAMEDQSRIRTKAEQARLNLTTNGSWKMPAHTGDRAAALRKLTHRRRYLRATNISISDGLYMRAELEERMRETLEAKSTACSGIDWVALTQRIVTDYSTELLELRTLLAGSTPRTNASEIRSWLSDIRTLIHALYMPYYEYPSHTPSTIDQAFSTAHPSSLAALDLCKTQHNVLDLNQPLSKSENVTYTSILETLNSICSVLLPLFLSTERLWLQHFNNITRLPNLTPDLRSTISSTTLSNLQALEELMAWLGWDEQYTTCNPGCELGQVCAIPIWPVMGTGHFSGPNGEGRRPGRDGGQREGYDEYDTWLEAKCVEYGARNFGMSDMMLAEERW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKA4</accession>
    <name>N1QKA4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ArfGap-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_122965</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765746.1">
        <property type="nucleotide sequence ID" value="XM_016901813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QKA4"/>
    <dbReference type="STRING" id="692275.N1QKA4"/>
    <dbReference type="GeneID" id="27898950"/>
    <dbReference type="eggNOG" id="KOG0703">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023062_3_3_1"/>
    <dbReference type="OMA" id="SDCKRNK"/>
    <dbReference type="OrthoDB" id="10266696at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08839">
        <property type="entry name" value="ArfGap_SMAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000010">
        <property type="entry name" value="Stromal membrane-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051718">
        <property type="entry name" value="ARF_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044732">
        <property type="entry name" value="ArfGAP_SMAP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705:SF1">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="3">
        <location>
            <begin position="15"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="124"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="279"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="370"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="467"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="514"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="531"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF17625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="584" mass="60887" checksum="97D0C32F77D0F062" modified="2013-06-26" version="1">MSRRAAGPDKAEQNRATLKQLVKLETNKSCADCKRNKHPRWASWNLGVFVCIRCSGIHRGMGTHISKVKSVDLDSWTDEQMASMLKWGNGRANKYWEHKLAEGHVPNEAKIENFIRTKYDSKRWVMDGPMPDPSTLDDGGADDDVPLNVVQQQVRERERSASLRNGQATGAMPGPPRAQQPQMDLFGDMSEPAAQPARPSTTEPSLSRPAPPKSSVAPPKPTRPGESLLGMDFFGGAQSAPPARPSSTGPNAAASSSGRSDLKQSILSLYASKPIAQPAQPAANAFSGMSSPLASPTVQQSNTQALGGLGDAFGSLSFSSPPVQPKAAPFSNFSAPSGHSRQASASGQQPKASILSGGSFFDAKPAAPPKQTSPLTSPPVQTRQTRDSFGADFGDFSSASPVTSSATKTSAPPAASSMGDLFDMDSPPAPPSKTANKPPLIQAANFAAFNLSQQQQPPPPAPKAAPTSSTSNFASTNVWDSNDAWASPDPEPARQTTAAPPVTKAPSPVASFKPTPSVSTSAFDSGWGDAPTNTSTSASGFSVQQDEEFGGWSHASPVATTPGPAKSGGGGATNSDDLFGNVWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKH8</accession>
    <name>N1QKH8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Decapping nuclease</fullName>
            <ecNumber evidence="7">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_68074</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA. The NAD-cap is present at the 5'-end of some RNAs and snoRNAs. In contrast to the canonical 5'-end N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay. Also acts as a non-canonical decapping enzyme that removes the entire cap structure of m7G capped or incompletely capped RNAs. Has decapping activity toward incomplete 5'-end m7G cap mRNAs such as unmethylated 5'-end-capped RNA (cap0), while it has no activity toward 2'-O-ribose methylated m7G cap (cap1). Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5'-end triphosphate to release pyrophosphates. Stimulates exoribonuclease activity of Rat1, allowing it to degrade RNAs with stable secondary structure more effectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside-ribonucleotide in mRNA + H2O = a (N(7)-methyl 5'-triphosphoguanosine)-nucleoside + a 5'-end phospho-ribonucleoside in mRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66928"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17313"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:172876"/>
            <dbReference type="ChEBI" id="CHEBI:172877"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:66929"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60880"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:15698"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:144029"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:60881"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78683"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:78684"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DXO/Dom3Z family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="7"/>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760421.1">
        <property type="nucleotide sequence ID" value="XM_016909809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QKH8"/>
    <dbReference type="STRING" id="692275.N1QKH8"/>
    <dbReference type="GeneID" id="27906946"/>
    <dbReference type="eggNOG" id="KOG1982">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024877_4_1_1"/>
    <dbReference type="OMA" id="ACTPYEN"/>
    <dbReference type="OrthoDB" id="5853397at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034353">
        <property type="term" value="F:mRNA 5'-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110155">
        <property type="term" value="P:NAD-cap decapping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013961">
        <property type="entry name" value="RAI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039039">
        <property type="entry name" value="RAI1-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395:SF9">
        <property type="entry name" value="DECAPPING AND EXORIBONUCLEASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395">
        <property type="entry name" value="DOM-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08652">
        <property type="entry name" value="RAI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RAI1-like" evidence="9">
        <location>
            <begin position="20"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF12300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="393" mass="45942" checksum="7134DF6C87950571" modified="2013-06-26" version="1">MLHFKFHDLTPFQAKSAAIKRPREITEFSFDDKHVCFPLDDRSLRYYYPPFFHLPGDRAQNRIDLSKGYESFEKYNDQPNLHLNPLLDTIRHHEQKTGTRLDADIITWRGMMTKILTAPFDEYGEFEMNATVYQGTIYIEENQSAKEAQTKVEDSQQRARRAMFDPDQMSFWGYKFETLSTLPRPLAECSREEVENRENEIVNNYAQYCSVVRTGIGNHTIVIGGEVDAVEGCKPDNPDDPIPYVELKTSASFRASDHRAASKFERKMCRFWAQSFLLGVPKIIIGFRTVHGHLERLEEWKTLDIPTFVQRQGLRTWNGNTCINFAAAFLDFLREHVRGNGTWTIERRKGAQEISLHKISEEYSREIVPPVFYEHREQQQQQQQQKEEEEGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKJ7</accession>
    <name>N1QKJ7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_20850</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60292"/>
            <dbReference type="Rhea" id="RHEA-COMP:15535"/>
            <dbReference type="Rhea" id="RHEA-COMP:15548"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.356"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765826.1">
        <property type="nucleotide sequence ID" value="XM_016908333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QKJ7"/>
    <dbReference type="STRING" id="692275.N1QKJ7"/>
    <dbReference type="GeneID" id="27905470"/>
    <dbReference type="eggNOG" id="KOG1079">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074460_1_0_1"/>
    <dbReference type="OMA" id="MANCTHR"/>
    <dbReference type="OrthoDB" id="6141102at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140951">
        <property type="term" value="F:histone H3K27 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026489">
        <property type="entry name" value="CXC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045318">
        <property type="entry name" value="EZH1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041355">
        <property type="entry name" value="Pre-SET_CXC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45747">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE E(Z)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45747:SF4">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE E(Z)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18264">
        <property type="entry name" value="preSET_CXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51633">
        <property type="entry name" value="CXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CXC" evidence="8">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="7">
        <location>
            <begin position="87"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF17705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="203" mass="23048" checksum="A8FDF35828506F72" modified="2013-06-26" version="1" fragment="single">CEKSCGCGPGCKRKWQGCLCHSGRRPKGKSVCWEDDRCACWQKSRECDPDLCGDCGVADVLDPVHRHDESILQNRCGMASLQRGVAKHTIVGDSGVHGLGLYACEDIRVDEFVGEYKGETITKEEADRRGAVYEHQKLCYLFTLNRQQEIDSTYFGNKTRFINHIDGFKSNLRPLISMVNTVFRIGMYAKKNIRAGEEFFFDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKL2</accession>
    <name>N1QKL2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Spermine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_146694</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the spermidine/spermine synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765846.1">
        <property type="nucleotide sequence ID" value="XM_016903802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QKL2"/>
    <dbReference type="STRING" id="692275.N1QKL2"/>
    <dbReference type="GeneID" id="27900939"/>
    <dbReference type="eggNOG" id="KOG1562">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048199_1_0_1"/>
    <dbReference type="OMA" id="FLYHEMM"/>
    <dbReference type="OrthoDB" id="38125at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004766">
        <property type="term" value="F:spermidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.140.10:FF:000001">
        <property type="entry name" value="SPE3p Spermidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000013">
        <property type="entry name" value="Spermidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.140.10">
        <property type="entry name" value="Spermidine synthase, tetramerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00198">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030373">
        <property type="entry name" value="PABS_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001045">
        <property type="entry name" value="Spermi_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030668">
        <property type="entry name" value="Spermi_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035246">
        <property type="entry name" value="Spermidine_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037163">
        <property type="entry name" value="Spermidine_synt_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002010">
        <property type="entry name" value="PRK00811.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00417">
        <property type="entry name" value="speE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11558:SF11">
        <property type="entry name" value="SPERMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11558">
        <property type="entry name" value="SPERMIDINE/SPERMINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17284">
        <property type="entry name" value="Spermine_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01564">
        <property type="entry name" value="Spermine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000502">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01330">
        <property type="entry name" value="PABS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PABS" evidence="5">
        <location>
            <begin position="11"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF17725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="292" mass="33086" checksum="1943896685D6A55F" modified="2013-06-26" version="1">MAEITHPTIVDGWFREINHMWPGQAMTLKVNQVVHHEKSKYQDVLIFESSDYGMVLVLDNVIQCTERDEFSYQEMIAHLALFSHPNPRKVLVIGGGDGGVLREVVKHPSVEEAILCDIDEAVIRLSKKYLPGMAVGFNHPKCKTHVGDGFKFLDDYKNEFDVIITDSSDPDGPAEALFQKPYFQLLHDALREGGVISTQAENPWLHLSIIQQLKKDCKSVFPVAEYGWTTIPTYPSGQIGFMVCTKDASRDVTKPLRTLDDAEEDKLFKYYSKKVHEAAFVLPKFAEKALRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKU4</accession>
    <name>N1QKU4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">H/ACA ribonucleoprotein complex subunit NOP10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Nucleolar protein 10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Nucleolar protein family A member 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">snoRNP protein NOP10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_149672</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NOP10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759917.1">
        <property type="nucleotide sequence ID" value="XM_016905701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QKU4"/>
    <dbReference type="STRING" id="692275.N1QKU4"/>
    <dbReference type="GeneID" id="27902838"/>
    <dbReference type="eggNOG" id="KOG3503">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_184680_2_0_1"/>
    <dbReference type="OMA" id="HRIIIKK"/>
    <dbReference type="OrthoDB" id="13807at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904874">
        <property type="term" value="P:positive regulation of telomerase RNA localization to Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031118">
        <property type="term" value="P:rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007264">
        <property type="entry name" value="H/ACA_rnp_Nop10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036756">
        <property type="entry name" value="H/ACA_rnp_Nop10_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13305:SF0">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13305">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NOP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04135">
        <property type="entry name" value="Nop10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144210">
        <property type="entry name" value="Nop10-like SnoRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF11796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="66" mass="7634" checksum="3FE07ECAD6664A1C" modified="2013-06-26" version="1">MHLMYTLDSEGKRVYTLKKVVGSEVTKSAHPARFSPDDKYSRHRVTLKKRYGLLLTQQKDKVVLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1QLC2</accession>
    <name>N1QLC2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_145676</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764549.1">
        <property type="nucleotide sequence ID" value="XM_016903195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QLC2"/>
    <dbReference type="GeneID" id="27900332"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="OMA" id="FYTRYEF"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF21">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="433"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="468"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="493"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="526"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="557"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="82"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="349"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF16428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="648" mass="72540" checksum="2D54C53D18E89290" modified="2013-06-26" version="1">MPDSPNSDHELQKLHRDSLDEQEEEVEETRPSEDHMDGSGIPSARRERHHHERQPLSAKASGRTERQLDINRRTVRKLDTILLPFLALLFLLNSLDKSNIGNAETAGFTQDTGLSREDVHTSMGIFFFVFVLLQPVGAALGRRFGMRRYVPICMSLWGLTTILHIFVRKRWHLIVLRVLIATLEAGFYPTTVSYMSLFYTKFEFATRLGFFYGMTAVAGVVGGILSWAVFSEFPGHTDNPDAPNLGPPSRRAQGTAGWKSWEVLFLIEGCLTMTVALLGFPWLPRSADSAWFLNAEERAWAESRMREDVHQNDVKIEHDSDDVNSSMLHSDYDPDARVLSNRYDHAGDESHERLLDEEDPLSPEQRQKSTISAASVTRDAGLSTHDVVSAVFNYKIWHLLVCNVLSAIPATAFGVLLPILVKELSPSLNLSPAASNLLSAPPFAFGAMALFVFVIWSDRAQRRLAPILWGLLILLLGLTLTVVAPIGHYWLRYFSLCVLLSGSFIASPLTVAWLANNTPEPGKRAILLGINGWGNLAGVFVSVLFRPEDKAAGYVRSFSILLVCVLASLVGFASFRVLIIRENRWRHDVLRSWSAEEKEREDTLGDVPAPDDYRMRVAKSSGLLKLARRAGLEEGRQGDERLTFRYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>N1QLQ1</accession>
    <name>N1QLQ1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_145869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764794.1">
        <property type="nucleotide sequence ID" value="XM_016903312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QLQ1"/>
    <dbReference type="GeneID" id="27900449"/>
    <dbReference type="HOGENOM" id="CLU_2723826_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF16673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="72" mass="7783" checksum="73F4792A02DEE5CB" modified="2013-06-26" version="1">MPSCAEGDTVSDDAPVCSLPATLGVQPAWQKRQHNSHKAADRSSTARDVAKQGRHPSNRSETDTDLQQRLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1QM92</accession>
    <name>N1QM92_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_146467</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts with hulA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765548.1">
        <property type="nucleotide sequence ID" value="XM_016903668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QM92"/>
    <dbReference type="STRING" id="692275.N1QM92"/>
    <dbReference type="GeneID" id="27900805"/>
    <dbReference type="eggNOG" id="KOG3780">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018982_2_0_1"/>
    <dbReference type="OMA" id="GMATPFH"/>
    <dbReference type="OrthoDB" id="2333384at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="4">
        <location>
            <begin position="205"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="412"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="477"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="504"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="532"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF17427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="646" mass="70862" checksum="53A11DAB646349F8" modified="2013-06-26" version="1">MAGTPTHPVLNWQGIASIRTPSMNSSRIHSASSTSLTRHHSKPWLEILPDVRFVVFHGNEHEAQTVKLQGFVRLHSPEPMSILKPKVRLEGKRKISWWYMGGISAGEVVDKRVFWIQEQKLGIESAHKVKAGTIDWPFEFELSPTMPESVEGLRETYIAYHVHASVSRPGWNAKDITTQEHIRIVRTLGQDSMEMTRSRVNADIWANKISYSISIPTDAIVFGTSITADVELSPIKKGLRLGKIELRLMETVVKRIQATEVPDIRGDRSKTEETEVAKADMEFPEDSRIVYDDETLENPTLADEMYKFKATLPLPKSLNICRQDVDSHSINITHRFKLMVNIHNPEGHVSQLVCRLPVKLFISPNLPVDESNEVTVNTTGVSDAELNSSETAVVAPPEYGRHQLDQMYSDIDSSGFMSRAGSGPGTPNGFSAQSRRGSHENILSLNGLADGDLASLHGSAMPHLLHSRLADLQEDGHTNGYAAQGSSRHHSPSGGNSPAPGVARSRDHSPERAHRSTPPVRNGSYFPHGDTSAHSSAPMSARTSSEEHTSGTDIHAQDYNLNDLSRVPSYGAALRTPGAVTPFTEGPPSYLEATSRPPSPIQRPIALHMRSGTSTPSTQGSNHTLTTPFAALNLGTMNGAVTPQRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1QMP5</accession>
    <name>N1QMP5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MED8</name>
        <name evidence="11" type="ORF">SEPMUDRAFT_56450</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764885.1">
        <property type="nucleotide sequence ID" value="XM_016909402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QMP5"/>
    <dbReference type="STRING" id="692275.N1QMP5"/>
    <dbReference type="GeneID" id="27906539"/>
    <dbReference type="eggNOG" id="ENOG502S8U1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074399_1_0_1"/>
    <dbReference type="OMA" id="WAPIEAN"/>
    <dbReference type="OrthoDB" id="5329317at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019364">
        <property type="entry name" value="Mediatior_Med8_fun/met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13074">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13074:SF9">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10232">
        <property type="entry name" value="Med8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="188"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF16764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="260" mass="28652" checksum="8D44E6B7C4944273" modified="2013-06-26" version="1">MAHTQPETSTLPLPPEHVKAIDQLRMRLSGLSTSIGLLLAELQSPKHDPLLAWPELQKASVKLGANLEALASALSSQRQLFTSLHVYPLPTFPGDTQEALLQQLLRKKLETKAEDWIEESVHISDDPRSNGAAGVLKAEDMRDLWSSAMEIQQAMVAQLTEDQVWDDDYTIREREMGVDKVITGLKRKLDQGEEDEEDDDDDDDVDEDGEGKAEKDDLVGEADRMDVDGPQAPAVAGLTTSLPPLLLDSVLKYAHGQDVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1QN55</accession>
    <name>N1QN55_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cx9C motif-containing protein 4, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_138215</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CMC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765654.1">
        <property type="nucleotide sequence ID" value="XM_016902870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QN55"/>
    <dbReference type="STRING" id="692275.N1QN55"/>
    <dbReference type="GeneID" id="27900007"/>
    <dbReference type="eggNOG" id="ENOG502S7M4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_177210_0_0_1"/>
    <dbReference type="OMA" id="YQEEKCQ"/>
    <dbReference type="OrthoDB" id="13601at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1130:FF:000008">
        <property type="entry name" value="Cx9C motif-containing protein 4, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1130">
        <property type="entry name" value="CytochromE C oxidase copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027179">
        <property type="entry name" value="CMC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15590">
        <property type="entry name" value="CX9C MOTIF-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15590:SF0">
        <property type="entry name" value="CX9C MOTIF-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08991">
        <property type="entry name" value="CMC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="15"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR627179-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF17533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="81" mass="9048" checksum="D5473671FFDD0C73" modified="2013-06-26" version="1">MPTTPEEGLKADPPCHPQACAIQACIQKNNYDEAKCQRQIDALYECCNQFYQKEGDDASTVSCPKASLLRLKMKQRLQGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNF2</accession>
    <name>N1QNF2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_19358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765355.1">
        <property type="nucleotide sequence ID" value="XM_016908316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNF2"/>
    <dbReference type="GeneID" id="27905453"/>
    <dbReference type="eggNOG" id="ENOG502SBM6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040837_1_0_1"/>
    <dbReference type="OMA" id="INWAKYQ"/>
    <dbReference type="OrthoDB" id="20473at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF17234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="231" mass="25418" checksum="B5F8E1FED4DA425F" modified="2013-06-26" version="1" fragment="single">SPVAPAYSPITPKVQPVLPACTAPPLVSPEEHHDPHMPRDAPSLLPPAASRIPPANYIPQPPSLPFSSDDAGDAIALRAAISTLQFQKKKAQHDIHTLVTIKQRALDQPETFKDELAAGRLREQRPSLGDLRAILDNIEDDDLDDEPSQLAPPKIKAESEHEVQKHFPRIPGPQTVVRMPHVNWAKYGIAGEPLDALHEQQRRWPGAFGHGDRGREYAIAAPYSPFMDAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNL0</accession>
    <name>N1QNL0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_35708</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765500.1">
        <property type="nucleotide sequence ID" value="XM_016908617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNL0"/>
    <dbReference type="STRING" id="692275.N1QNL0"/>
    <dbReference type="GeneID" id="27905754"/>
    <dbReference type="eggNOG" id="ENOG502S05G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069858_3_0_1"/>
    <dbReference type="OMA" id="CENCISV"/>
    <dbReference type="OrthoDB" id="432970at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024119">
        <property type="entry name" value="TF_DEAF-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10237">
        <property type="entry name" value="DEFORMED EPIDERMAL AUTOREGULATORY FACTOR 1 HOMOLOG SUPPRESSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10237:SF14">
        <property type="entry name" value="MYND-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="10"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF17379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="240" mass="26942" checksum="E308C2BC97E66A42" modified="2013-06-26" version="1">MSTTELAQVCAKCNNTEGELKKCTKCKSVLYCNRECQRAHWKKHKRQCSRLAGEGAPPPAQTGSGSNSSSAANPFTRLSENTFLHDGSEEDTFRILVDVLRMRQEDTYTFEGETMPGTIYNGESSSEVAFRNMLWRAKQVQGLLPLWWSSEKEEECIRKNKEALQSAQEKSDIQEFWRDSLMPMKLRMVGETIYGNRPGSIGDGGQSMRHMQQFMGPGGLGMRSIHLDFGALKGGLVVEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNR6</accession>
    <name>N1QNR6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ras GEF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_130241</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765630.1">
        <property type="nucleotide sequence ID" value="XM_016902348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNR6"/>
    <dbReference type="STRING" id="692275.N1QNR6"/>
    <dbReference type="GeneID" id="27899485"/>
    <dbReference type="eggNOG" id="KOG2378">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005431_1_0_1"/>
    <dbReference type="OMA" id="HIAKWVA"/>
    <dbReference type="OrthoDB" id="8300278at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF348">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR RASGEF, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="5">
        <location>
            <begin position="467"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="691"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="369"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="599"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="127"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="169"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="375"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="393"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="610"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF17509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="948" mass="103785" checksum="AB2001529FA500A6" modified="2013-06-26" version="1">MSPQEQKVGQRYERQAQKGLASQGFRNGTRGSLPHNRTAGDDAAGVHGGGGGGGGGGGGGGGGGGGAAAAATAGAAGGAGLRRRPSSSTADTRASRTNPTPALLLEPSHASERVVPRTVPLATLSDNHNDSDIDSDDSHDADADADDADESDDTDDDDDPHEEDEGASVTGSRRSYHSVQHSEPLPEVNIAVVSAAAVGKSTFIKAALDLNRLPSSRAAEKRFPFGGCSYTLRLLELDLDDIDTHNDGTINWPDRIEDRITPKVDGALALYSCKEPSSIKDLRDMLKAVTKSALPIVLVATKCDVPSAERKVEPSVVEQNAKRINKNIATLQVSELNPEGYKRGILMLMNAIVKLSPEHPSGLTRVASLRRRAQSSTTIPSSPRSSLAGHSRASSEHTGIKDPRHSRIDPSFAGHSTGERLRVPRSEDQMHGSFLLEESGSEPSAASTRSSASTDALSVVPGASPLSALAENGATFDELVDRLLDQPTSKADLKFASIFLALYRNFAAPGKLLEAIVQRFDTLEQNGSPMMMKSTTQLRYLAVVEKWVSAYPGDFAFPKTRQRLQTFTHKISDTRIFTTAAKEISIALEAVHEDDDTSWAYNDKDREASGEQSESSLASSADTLIDDPAFTFDTELSGTTPSVDSDIYKGPKISNQMIAYVEQAQRHARELQPIQRNTLTKIQWRALMDQPDELIARELTRIDWIMFSSIRPRDLVRHVSLSKEQRQLCRNLAHVERMIQHFNQIAFWVANYVLLRDKPKHRVLMLEKFMRVARKLRELNNYNALGAVIAGVKSTSVHRLVATREMVQPGVGKDWLKLEILMAPSRSHFAYRLAWENSSGERIPYLPLHRRDLASAEEGNRTFIGDDGRINWKKFEIMGDVIVGLQRAQGMPYKNLGGLQGNQQVKELLLDVKLLKDEDELYERSTQIEPPANASVGPSAKFKQFFQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1QP21</accession>
    <name>N1QP21_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Guanine nucleotide exchange factor Vps9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_146890</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF18009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016766130.1">
        <property type="nucleotide sequence ID" value="XM_016903940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QP21"/>
    <dbReference type="STRING" id="692275.N1QP21"/>
    <dbReference type="GeneID" id="27901077"/>
    <dbReference type="eggNOG" id="KOG2319">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007625_0_1_1"/>
    <dbReference type="OMA" id="TFITNKM"/>
    <dbReference type="OrthoDB" id="300289at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14369">
        <property type="entry name" value="CUE_VPS9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041545">
        <property type="entry name" value="DUF5601"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041804">
        <property type="entry name" value="Vps9_CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF25">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN AND VPS9 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18151">
        <property type="entry name" value="DUF5601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00546">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="3">
        <location>
            <begin position="428"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="CUE" evidence="2">
        <location>
            <begin position="763"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="611"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="677"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="614"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="645"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="729"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF18009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="808" mass="88510" checksum="F151958E0B4BD7EA" modified="2013-06-26" version="1">MSGVREAAAPTNEDEHDGLLASPTPPQSHTLLDHHKTDPVSAANLKDGEARVEGDDAVMSTTESEMQAAKQVEAEVRNELPEALETSDGEDVHARAEIERQASEHLARRASEMSLGEDDSDGNVDTRAKDKHHLPQTPPPPMPPRKDSLAKKQVAKEVEYDEKHPPSSEDAQVEVPEAPTGTTEATGTEILNIMDQFESGMGGMEAQAIMSPRLERQQPMLVLPPRSSSLEQQQSYVLSPKSTAPSVAAPTPIRPQGTGTSIASSLQGGTADDSSSITSARAGTLFQPPPPSPEPEAALPFDFHRFLEQLRNKSADPVARYLRSFLGEFGKRQWMVHEQVKIISDFLEFISRKMAQCEVWRTVSDAEFDNAREGMEKLVMNRLYSFTFSPAIPAPPSSPRKSARSTRAQADHANVHGPGRRGQHQEDVERDEVIAQKIKIYGWIREEHLDVKSLGPKGDKFLTLAQKELLKINSYRAPRDKVICVLNCCKVIFGFLKNAKQDQSADAFVPLLIYTVLRARPENLVSNVQYIWRFRNQDKLGGEAGYYMSSLMGVVTFIENLDRTNLTIQDEEFEQNVEQAVSAIAEKNRQEEHDAKTSASRTAGLMISHVSEKSGLSQPEVTPRNSMEVETSSPRRKASQRLSEKTSGSSNNPAPNADEPDAMTGLLRSIQKPLSSIGRIFSDDGGGGGGSSSDDRSASTPQPGSTPRGLSPAGRVERSSRNHGGTRSSTERRRSQQRQSAEDMAARQASADVAQAQAVRVREHKVVVETLQSMFPNLDHEVIEDVVRAQEGNVGRAVDACLALSSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M3ARN0</accession>
    <name>M3ARN0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SURP motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_152422</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF08154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756275.1">
        <property type="nucleotide sequence ID" value="XM_016907438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3ARN0"/>
    <dbReference type="STRING" id="692275.M3ARN0"/>
    <dbReference type="GeneID" id="27904575"/>
    <dbReference type="eggNOG" id="KOG0007">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013259_3_1_1"/>
    <dbReference type="OMA" id="VKYQEQQ"/>
    <dbReference type="OrthoDB" id="447637at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.790:FF:000001">
        <property type="entry name" value="Splicing factor 3a, subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.790">
        <property type="entry name" value="Surp module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045146">
        <property type="entry name" value="SF3A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022030">
        <property type="entry name" value="SF3A1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000061">
        <property type="entry name" value="Surp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035967">
        <property type="entry name" value="SWAP/Surp_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15316">
        <property type="entry name" value="SPLICEOSOME ASSOCIATED PROTEIN 114/SWAP SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15316:SF1">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12230">
        <property type="entry name" value="PRP21_like_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01805">
        <property type="entry name" value="Surp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00648">
        <property type="entry name" value="SWAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109905">
        <property type="entry name" value="Surp module (SWAP domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50128">
        <property type="entry name" value="SURP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="SURP motif" evidence="9">
        <location>
            <begin position="46"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="SURP motif" evidence="9">
        <location>
            <begin position="144"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="332"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="496"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="228"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF08154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="534" mass="60369" checksum="88212F2197A1610E" modified="2013-05-01" version="1">MAATNGAQPAEAAAAAAVPPADGQESDLQKRMPAGTVLPPRPVREKIERVAVYVARNGQAFEDNVRTKNAGTNTTHFLEPSDEYNGYYKWRVAECKAGRSLDSNGPAAKTDVTFQGRESRAPKAPEEFQFSARMPNISAQDLEIVKLTALYAAKNGKSWVTSLSQKEAVNAQFDFLRPQHSLNMYYGRLVDQYKDLIEGETADDGAPQKKRISALQANIDNRFSLLEKAKQRAEYVKYQERQKEEKEEKLEKDRIEFAQIDWHDFNVIATIVFDEADESATMEYPRTLNEMLSLSLEEKANMRIDSNRRIEESVPEFNDYSAIYGHEQQFPAAQMMPPPQGHAPQQPFGSTPPQTTPYQQPAAPSLSEEREHARAAIRATQAQPTRVRTDYVPRAQQRNQQQNTSICPNCHQTIPNDEIAEHMRIEQLDPRWREQFGKNQQRSSTTNLSTVDVANNLKRLASQRTDLFDPVTGQAITEEEKERRKRAELQSYDGISQVPNAAIGQAPPGIYPPGTQGTNVNEDIRRIHERYNHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M3ATM8</accession>
    <name>M3ATM8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_128455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756990.1">
        <property type="nucleotide sequence ID" value="XM_016902214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3ATM8"/>
    <dbReference type="STRING" id="692275.M3ATM8"/>
    <dbReference type="GeneID" id="27899351"/>
    <dbReference type="eggNOG" id="ENOG502RZPZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013481_1_0_1"/>
    <dbReference type="OMA" id="WETDHII"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="186"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF08869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="511" mass="56756" checksum="90877EF76E8030A0" modified="2013-05-01" version="1">MRDGAIRALGNLETSISCGQHVFCERPPAHVGTQNRNHTASGSSTSLVRRIASASCLSPVSAARRRCRQELQIHHPSPFLNMEILDIHLARSQISGASTPSGISAVTSYSTEALQRTASEQISQSVLENPFELRYGRRYLRSDMSYPFPCDLAELQRQSLRTLLGIQVFGGPFCNPKFKEKPPKKVLEFGCGTAFWSAMCHDHFVARGHKHIHFVGTDIAPLAPNLQRQGMNWTFFQLDMRRIPMPFKDKEFDLIVFKDLSLVMPLEARSEEILGEAIRILKPGGCIEVLETDHVIRFLASRPPSRSSKPDEQENAVRTATFPIPIGHPFAPAQNKYLQKANKWIEESLHRRRLNPSPTSRIAEMLTQGPDLKNVGYRRIAVPLGELQWERDARHTNPNSGEHESTSSIGSCNTTPIAGSGQNLTPDQLALRQTALMTVLGQIESMEPMLKEASGKNSEEWSLWWAAMMTDLLDPANGGLVGECLEMGAWWATKAGNPDELDEGAVDKSDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M3AVR0</accession>
    <name>M3AVR0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_143901</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758282.1">
        <property type="nucleotide sequence ID" value="XM_016903056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AVR0"/>
    <dbReference type="STRING" id="692275.M3AVR0"/>
    <dbReference type="GeneID" id="27900193"/>
    <dbReference type="eggNOG" id="KOG2028">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017985_0_1_1"/>
    <dbReference type="OMA" id="RIILSQC"/>
    <dbReference type="OrthoDB" id="10265467at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051880">
        <property type="term" value="F:G-quadruplex DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033567">
        <property type="term" value="P:DNA replication, Okazaki fragment processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000731">
        <property type="term" value="P:DNA synthesis involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006282">
        <property type="term" value="P:regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000001">
        <property type="entry name" value="Putative AAA family ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000137">
        <property type="entry name" value="Replication-associated recombination protein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3710.10">
        <property type="entry name" value="DNA polymerase III clamp loader subunits, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032423">
        <property type="entry name" value="AAA_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051314">
        <property type="entry name" value="AAA_ATPase_RarA/MGS1/WRNIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021886">
        <property type="entry name" value="MgsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006642">
        <property type="entry name" value="Rad18_UBZ4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13779:SF7">
        <property type="entry name" value="ATPASE WRNIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13779">
        <property type="entry name" value="WERNER HELICASE-INTERACTING PROTEIN 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16193">
        <property type="entry name" value="AAA_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12002">
        <property type="entry name" value="MgsA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00734">
        <property type="entry name" value="ZnF_Rad18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51908">
        <property type="entry name" value="ZF_UBZ4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBZ4-type" evidence="12">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="80"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF10161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="592" mass="64636" checksum="CB9BB9107FC7281B" modified="2013-05-01" version="1">MVCCPICEKPVLEADINRHIDSGCKKFIEGVSPPATFSQLAPPATQPNGTKPKSTQSARFFTPAAKKSAIFRADEVSSPAAIPTPISRPSIAPASTAPVKRRRDEDHDEHHPEAVLPPAKKAKDAHKPLAERMRPQSLDDVAGQELVGPHGVLRNLIVSDRVPSMILWGGPGTGKTTIARLIAQTAGTRFVEINSTSSGVAECKKLFAEAKNEMGLTGRKTIIFCDEIHRFSKSQQDVFLGPVEAGQVTLIGATTENPSFKIVNALLSRCRTFVLSKLTDEHIFGILKRALAREVPSLPTPSPSPSEEGSLDAADTAESSLSLLSDDDYSLIRYLAAFADGDARTGLNLLELALDLCQKPHTTIEDIKKSLTQTLVYDRAGDQHYDTISAFHKSVRGSNADATLYYLARMLQSGEDPLYIARRMIVIASEDIGLADNTMLSLATATYSAAEKIGMPECRINLAHCAVALALSPKSVRAYRGLNAAYTALHEPGIAGLPIPKHLRNAPTKLLKELEHGKNYKYNPDYVQGRVVQDYLPEKLEGKRFLPVAHLGDQIDPEVAEWDEQVRVMAEHDEKIHQEEEEEEVLLNPDGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>M3AVZ1</accession>
    <name>M3AVZ1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_151246</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758377.1">
        <property type="nucleotide sequence ID" value="XM_016906694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AVZ1"/>
    <dbReference type="GeneID" id="27903831"/>
    <dbReference type="HOGENOM" id="CLU_2374131_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF10256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="95" mass="10061" checksum="E9A3744CF7060921" modified="2013-05-01" version="1">MGTILPSDLSPRTACPCRLTYCSLSIGQHSFDSSMMGIQASVATIHAPPGPQLSVFGSSTRDIRSHLCGSLVAPLLFVMLSELTAFIIPNPFHAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M3AW97</accession>
    <name>M3AW97_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Brix-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_164608</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759131.1">
        <property type="nucleotide sequence ID" value="XM_016908120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AW97"/>
    <dbReference type="STRING" id="692275.M3AW97"/>
    <dbReference type="GeneID" id="27905257"/>
    <dbReference type="eggNOG" id="KOG2963">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026936_2_0_1"/>
    <dbReference type="OMA" id="KDYTVMT"/>
    <dbReference type="OrthoDB" id="10261452at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045112">
        <property type="entry name" value="PPAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12661">
        <property type="entry name" value="PETER PAN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12661:SF5">
        <property type="entry name" value="SUPPRESSOR OF SWI4 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="38"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF11010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="480" mass="53684" checksum="79D96C5BBD16AB2F" modified="2013-05-01" version="1">MAKRRTKKYTHVGAAKGGIPQAKGPQGIAKSAARTPKSMVIRVGASEVGHSVSQLVKDVRRMMEPDTASRLKERRSNKLRDYTTMAGPLGVTNLMLFSKSESGNTNLRLAYTPRGPTLHFRVEKYSLCKDIYQSMKRPKSGGQEYLTAPLLVMNNFITKDLDSSSKDAQEKAKTKQLEDLVQQMFQGLFPPVNPTRTPINGIKRVLLLDRVPRKASAENDDSAPYVLNVRHYAIETRTARSVPKALRRLDAAEKLSHTGQKRKRALPNLGKLNDVADYLLDPTAADAEGFTSGSDSEVETDAEVEITTTKQRKVSKHGKKATGANGTQVAQSSQSSAKDNVEKKGIKLYELGPRLKLRMTKVEEGLCGGKVMWHEYFHKSESEIKEMEKVHEQRNREKAERKKEQKANVERKKQERRDAKRGQEKGKDGEEVEESEDELVDYWESEDDDDQYTGAGASGDEMEEDDGSAEEGDDDEHEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M3AY59</accession>
    <name>M3AY59_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short chain dehydrogenase/reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_149102</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760538.1">
        <property type="nucleotide sequence ID" value="XM_016905342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AY59"/>
    <dbReference type="STRING" id="692275.M3AY59"/>
    <dbReference type="GeneID" id="27902479"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_12_1_1"/>
    <dbReference type="OMA" id="PWKIRAN"/>
    <dbReference type="OrthoDB" id="2898618at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF18">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G12480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF12417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="291" mass="31029" checksum="E3BC0BD990F62560" modified="2013-05-01" version="1">MASPSDTKNLGDVSGLVAVVTGGGTGIGLIIAKALEANGAKKVFITGRRQDRLDAAAKQAVHGNIIPIQGDATSHDDAQRAVDAVTKEVGYIDLLICNAGQTTRDGSPDARPKPTGESSIQEIRDYYFNYRPQEVWQSCLETNVVSVFTTTMAFLELLDLGNKRRDPSAPTSQVIAIGSVGGLVKFTDSFIYNASKAGVHHLMKNLGNFLVPHDIRTNIIAPGYFASEMTAGVVQNFEQTGGVMPRSLVPRQRMGSEEEMAGTVLYLASRAGGYCNGNLMVVDGGIWANHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M3B182</accession>
    <name>M3B182_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HAD-superfamily hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_148788</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761648.1">
        <property type="nucleotide sequence ID" value="XM_016905147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B182"/>
    <dbReference type="STRING" id="692275.M3B182"/>
    <dbReference type="GeneID" id="27902284"/>
    <dbReference type="eggNOG" id="KOG2914">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_14_1_1"/>
    <dbReference type="OMA" id="FEACADI"/>
    <dbReference type="OrthoDB" id="2107174at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07505">
        <property type="entry name" value="HAD_BPGM-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051600">
        <property type="entry name" value="Beta-PGM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46193">
        <property type="entry name" value="6-PHOSPHOGLUCONATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46193:SF18">
        <property type="entry name" value="HEXITOL PHOSPHATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF13527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="249" mass="27830" checksum="FA124271DFE2A624" modified="2013-05-01" version="1">MGKVKYILLDCDNTLCQSERLAFEACADLTNEVLKKYDIDATYTTESLLEDFVGNNFRNMLIGLQKKHNFSMSQADMEKYVDMELDRVTAKLAEKAVECPGVTEQLEWAKAQGYPMSVVSTSAKPRVVASLKKCNLMRFFTDEHVYSAATSMPDGPSSKPDPKIYLYACEQLGVKPEETLTVEDSKSGATAAMRAGIPLIGYVGIYGLEEGKEKEAQMVKTLTEVTKADFIMHDWKEFPEAVKKIEAKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>M3B2G3</accession>
    <name>M3B2G3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_163518</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762063.1">
        <property type="nucleotide sequence ID" value="XM_016908061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B2G3"/>
    <dbReference type="GeneID" id="27905198"/>
    <dbReference type="HOGENOM" id="CLU_1152367_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF13942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="241" mass="27283" checksum="1819A1CCA6F1D415" modified="2013-05-01" version="1">MQPSIASNSQMIAAAWASREEVVVQRAKTDVRFRLREHTIRSHIPLKPAMRTSSVSAWQRTLIPERIMSFSLLRMQLLLSARTDNGTFTHLENTRRCIVKTIKHSTKLKRSQMIVLPRTSMEPSVVPLAKQHIVPIRFKVKRIDKNEYCYCGYYDTPGDTTGPFIPYDFITSFVCLDRGWAAYPFGPDRTTHCANNQAFDQAQSFADDCFARYADGALCCQSKKKGCGKPVLGRNLTGTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>M3B331</accession>
    <name>M3B331_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_115498</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762333.1">
        <property type="nucleotide sequence ID" value="XM_016901167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B331"/>
    <dbReference type="GeneID" id="27898304"/>
    <dbReference type="eggNOG" id="ENOG502R8I0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1571620_0_0_1"/>
    <dbReference type="OrthoDB" id="3643633at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF14212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="170" mass="18950" checksum="A6FC0E02289D94A8" modified="2013-05-01" version="1">MHGPLVHSILACPWKRSSGPGAWRTALSQVSINAIYTAGHDFPLYASRRSCFDLPTAQVRSASPWLPSTLPVGFEEMNTQHILIPSLMHLVGRLDTVVPEDISAMARLDEIQQALIDWQVEDVTATTYCPTRTALEDEALRQVYLHMRLAALAVCGFIRFSMNTTAHEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M3B3C8</accession>
    <name>M3B3C8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GID complex catalytic subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glucose-induced degradation protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_148058</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the proteasome-dependent degradation of fructose-1,6-bisphosphatase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the RMD5/GID2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762418.1">
        <property type="nucleotide sequence ID" value="XM_016904671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B3C8"/>
    <dbReference type="STRING" id="692275.M3B3C8"/>
    <dbReference type="GeneID" id="27901808"/>
    <dbReference type="eggNOG" id="KOG2817">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020227_0_0_1"/>
    <dbReference type="OMA" id="LIRECKM"/>
    <dbReference type="OrthoDB" id="1933281at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16652">
        <property type="entry name" value="dRING_Rmd5p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000143">
        <property type="entry name" value="Regulator of gluconeogenesis Rmd5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045098">
        <property type="entry name" value="Fyv10_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037683">
        <property type="entry name" value="Rmd5_dRing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044063">
        <property type="entry name" value="ZF_RING_GID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170:SF3">
        <property type="entry name" value="GH10162P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170">
        <property type="entry name" value="MACROPHAGE ERYTHROBLAST ATTACHER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51867">
        <property type="entry name" value="ZF_RING_GID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CTLH" evidence="11">
        <location>
            <begin position="182"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="RING-Gid-type" evidence="12">
        <location>
            <begin position="376"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="RING-Gid-type" evidence="10">
        <location>
            <begin position="376"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00061136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00075398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00080744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF14297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="432" mass="48382" checksum="6F839E2D55E05ADA" modified="2013-05-01" version="1">MEAILAAHEQQEKKGNLSKAITDVQQLIDLLQSARDAVAESPDKAVLHLAKLSTPVKQSFTRMEDDLREVNRGINQYSKALKDKFKSAALPTASNDVLASQPNLINRAIAMHLLREGKFDVAKTFVREVKERPPANRAGGAQSDDMAGMSWIEDLEDTDEMMQDSMEGRSEAEMERSGLQQKFSDMYHILDALRNQHNLEPAIDWAHHHSQELEHRGSNLEFELSRLKFVELYHSKTDSMTDDEPDYLAGPVRALEYARNVFPTFGERYSRETSSLSASLAFSPNLQDSPYNALFHNQSAFEEASTSFTREFCGMLGLSSQSPLYTAVTAGGIALPVLEKFERVITQARGQWTSVNELPVETPLPPGFAFHSIFVCPVSKDQATDANPPMMLPCGHVLAKDSMDMHSKGKSRMKCPYCPQECHPRDAKRVYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M3B8C5</accession>
    <name>M3B8C5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_147760</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF16097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764218.1">
        <property type="nucleotide sequence ID" value="XM_016904510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B8C5"/>
    <dbReference type="STRING" id="692275.M3B8C5"/>
    <dbReference type="GeneID" id="27901647"/>
    <dbReference type="eggNOG" id="KOG2084">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018406_5_2_1"/>
    <dbReference type="OMA" id="HSCDYNS"/>
    <dbReference type="OrthoDB" id="5945798at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08161">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF251">
        <property type="entry name" value="EG:BACR7C10.4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="5">
        <location>
            <begin position="3"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="51"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="73"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF16097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="558" mass="63065" checksum="C0D8FAFAC21903AF" modified="2013-05-01" version="1" fragment="single">MAANVQVKQSGIESAGRGLFAKKDFQPGDIVLALNRPFVAELDQDRLRDTCAWCLQRGASAEDRAKATSLGLPIAGIETKACTGCKRVRYCSKTCQTRAWKREHKYECKVLAPAERPDLPHGVRAVVKLLGRLKADPEGKDQLLLDIVQFRPASDPKALEDIQRQDAQRFEDFSMLAYGAWKYAGEPMLGDMDSNAISKAFFFNIMSNTLQLSSALDDTKLGIAFDPILCSANHSCEPNTAVIFNQPQLILRAQTKIKKDEEIFMKYVDITNPFSVRQAELRQSYFFGCRCTKCRKGAIHVEDKFLKSTDTYGDDTSPTVRVDARLMKVADGLVQRHQSQLTSFWVPANSEVAQRRLAAIQAEAFATSGITFDHNKANESASEDEVKDALKLTINSGMWHITRQPVPHLLRQLLVLYVSQARTYQAWRVGIKMYFEVSPFLPGQLERFYPDRVIDTFMLATITNQLCNPNIQHHRELFAESMKTGLDLRVVYMMFLIEARENLDFSYGKDSPFGRVVESMYQQTMANSDILLKDAKDMIEEVWPKLEAVAKSIDVLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M3B8E8</accession>
    <name>M3B8E8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Oxidoreductase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_147781</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SO2202</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2012-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genome evolution in poplar pathogens from wild and recently domesticated pathosystems.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Dhillon B."/>
                <person name="Feau N."/>
                <person name="Sakalidis M.L."/>
                <person name="Gill N."/>
                <person name="Aerts A."/>
                <person name="Ohm R."/>
                <person name="LaButti K."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Copeland A."/>
                <person name="Beauseigle S."/>
                <person name="Grigoriev I.V."/>
                <person name="Goodwin S.B."/>
                <person name="Tanguay P."/>
                <person name="Hamelin R.C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF16127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764248.1">
        <property type="nucleotide sequence ID" value="XM_016904523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B8E8"/>
    <dbReference type="STRING" id="692275.M3B8E8"/>
    <dbReference type="GeneID" id="27901660"/>
    <dbReference type="eggNOG" id="KOG4690">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062297_0_0_1"/>
    <dbReference type="OMA" id="IVWDIFR"/>
    <dbReference type="OrthoDB" id="10064411at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019180">
        <property type="entry name" value="Oxidoreductase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039251">
        <property type="entry name" value="OXLD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21193">
        <property type="entry name" value="OXIDOREDUCTASE-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21193:SF3">
        <property type="entry name" value="OXIDOREDUCTASE-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09791">
        <property type="entry name" value="Oxidored-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase-like" evidence="2">
        <location>
            <begin position="132"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="278"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF16127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="295" mass="32822" checksum="E9420A201B156B87" modified="2013-05-01" version="1">MRPALRISSAFTRRNLPASAARTTASRASCPRPRLQTRRIAHTTRRNDKANTSSPYPGYEIDALDAPLHGERQHVDRPYADPSPEDLYPMTAKEVEKQDDENSTLARAKRVFGDRERDALERKRLMESKSRMIAGVLIPPKPEEPDNCCMSGCVNCVWERFREELEEYALKMKEAKTAQNIQRLQGQATGLMSAESDAPNHVAISMDDDGGGSETLWNDAIPEQVAAVIEGGAGGVEDDPFAGVPIGIREFMRTEKKLKELHKKRGEKMETALDTELRPAAWSTSTRSTTSASPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M3BNZ3</accession>
    <name>M3BNZ3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_121752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456287">
        <property type="protein sequence ID" value="EMF07898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756019.1">
        <property type="nucleotide sequence ID" value="XM_016901718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BNZ3"/>
    <dbReference type="GeneID" id="27898855"/>
    <dbReference type="HOGENOM" id="CLU_2348030_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF07898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="97" mass="11223" checksum="B3CCE9C24B034509" modified="2013-05-01" version="1">MARDILCIPAAGVRCERDFSIARHQSRFNRQYTAATFSGLMEILSEDREQTKDLMERISDLDTISDDEGDVVEEPRRSVRLSFKLAQECLRDATRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M3BSA7</accession>
    <name>M3BSA7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_16224</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757094.1">
        <property type="nucleotide sequence ID" value="XM_016907989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BSA7"/>
    <dbReference type="STRING" id="692275.M3BSA7"/>
    <dbReference type="GeneID" id="27905126"/>
    <dbReference type="HOGENOM" id="CLU_2475052_0_0_1"/>
    <dbReference type="OMA" id="KCICTNT"/>
    <dbReference type="OrthoDB" id="3065412at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="domain" description="CFEM" evidence="10">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="29"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="38"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF08973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="87" mass="8945" checksum="844F7BABECEF2758" modified="2013-05-01" version="1" fragment="single">PAPTPSSYVPTVADVPKCAQGCVTDLGGCATGDVNCVCRNTPYLNRLAVCVPQYCNATEVAQVVAFANFVCRSVGVTSLPSPSYAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M3BTE2</accession>
    <name>M3BTE2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_110345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF09925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758046.1">
        <property type="nucleotide sequence ID" value="XM_016900840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BTE2"/>
    <dbReference type="GeneID" id="27897977"/>
    <dbReference type="HOGENOM" id="CLU_573865_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="476" mass="52439" checksum="88793E6411DD411B" modified="2013-05-01" version="1">MNGPTSRISAKQPSGSVCNPRMGDGIPLCGEMEMRRQSASILKRTRHRKRPPTYTVQLPDGTRVDKIKLNDITDHVSIAELERFEHHQFALEANSVAAVECARPVAARSNSGSPLSSLTSSMFEDSAASRWISAQSPDARRQEACDRSWSREHKNVGILETSPGVYVAPIHPGGIQSSVKWVATRSLISARTIETGVDDQENPEWVAFIAQSGELEVRDTGYRGGGELWGTVDENDNTRGMMSSRRQKDWFLLPLVPAIEESSDLVAVSPVAEVVMGNLAANVEVQRHRLMNPATVNVGADLYLEVGGDGRKLVGSITSVLIDKSVLDSNGCPTWLNRTRGPPPLLIDMFDHKGKVLPGLRTHAAQLEENRILIIDGFWFEADYDTPDVAPEDAFFAALPHLANGYAFEGTIVVAPNQLKNPANKESLINKWKKSGFEVWQEWVEEEAPLVLGRTWTTVDVERDKNCSSSSRLHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M3BU28</accession>
    <name>M3BU28_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Manganese and iron superoxide dismutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_151186</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758291.1">
        <property type="nucleotide sequence ID" value="XM_016906658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BU28"/>
    <dbReference type="STRING" id="692275.M3BU28"/>
    <dbReference type="GeneID" id="27903795"/>
    <dbReference type="eggNOG" id="KOG0876">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057349_1_0_1"/>
    <dbReference type="OMA" id="MTAREPN"/>
    <dbReference type="OrthoDB" id="275227at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43595">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S26, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43595:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="2">
        <location>
            <begin position="167"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="2">
        <location>
            <begin position="284"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF10170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="353" mass="39410" checksum="A0E4EDFD28BDCA90" modified="2013-05-01" version="1">MITRRLLRPSSRFTQSPWTCAACTQRIPFITPPPQATATTTTMKTTTRSLSASSRLQEHRVPPLAFHDTFMEKGLSRKISETEMGEELLSPTGYYIAWVQYQTLLTQKLNELTAGQDFADKTPLDLALIFARDPLNAALFNHASMAFNNHFFFNSLSPAPLTLAQTPQLTESLVQTFGSIETLRATMIDTAASMFGPGFVWLVWARDPASSSRSSTTFSSRGGSWRILTTYLAGTPFPEAGYRQQGLDMSNNNPNSYQAYLQQQTSIPGNTAGMFGPYSQTAKQQATKPPGGTSVMPVLCVNTWEHVYLNDHQIFGKRKYLETWWNCVDWGLVQERAPGEAKGMDRFERSSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M3BUC7</accession>
    <name>M3BUC7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Large ribosomal subunit protein mL59 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_151269</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016906708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BUC7"/>
    <dbReference type="STRING" id="692275.M3BUC7"/>
    <dbReference type="GeneID" id="27903845"/>
    <dbReference type="eggNOG" id="ENOG502S29G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076154_1_0_1"/>
    <dbReference type="OMA" id="KGHKHEL"/>
    <dbReference type="OrthoDB" id="18529at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037507">
        <property type="entry name" value="Ribosomal_mL59"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040922">
        <property type="entry name" value="Ribosomal_mL59_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28041">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28041:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18126">
        <property type="entry name" value="Mitoc_mL59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Large ribosomal subunit protein mL59" evidence="2">
        <location>
            <begin position="17"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF10285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="186" mass="21063" checksum="21AC407103E3ED8E" modified="2013-05-01" version="1">MAAAMESQIRLAQQLPPRLLNFFKKYPPPQIRTATTPSTLTDSSSSSSDSPAAVTETTMTDSSSGLTDKKSHNPFLPFKNPRTGLWHGPAYSLRRQADLYKLAKAHFVLDLMPIAPKHPELKAQKRLEKGLLVQGTGEGKRVKGKLWERQLRSKMDERRQAMEGMNAMVKNWKERGHGRGWKKWPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M3BVB2</accession>
    <name>M3BVB2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_150244</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759390.1">
        <property type="nucleotide sequence ID" value="XM_016906043.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="27903180"/>
    <dbReference type="eggNOG" id="ENOG502RY6P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082451_0_0_1"/>
    <dbReference type="OMA" id="FMSISHY"/>
    <dbReference type="OrthoDB" id="3596006at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF11269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="240" mass="26564" checksum="AF008CBD98B8B028" modified="2013-05-01" version="1">MAPVIWGLDLKEIQWAKFKSSYMWNTTYHLRRTKFIVYQCALIFCVVSESLGTSALSDYVDSQKYVAALDDRVYVYNNDFVGVASFNIFAGIFVAFIFGAAFFFDLFWPERHESKSVLIAWKVCGVLSTIFYLASALALTVITANHCGYFRGPAGVNDGYGQSLLSQFSKDGGTPLCYRKNSRAVASVVFSWLGFVSVLGSCILLFFSIDHTEKGPGPKSTHARAEEDAEKSDTATTTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M3BVM5</accession>
    <name>M3BVM5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_157418</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759495.1">
        <property type="nucleotide sequence ID" value="XM_016907732.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.M3BVM5"/>
    <dbReference type="GeneID" id="27904869"/>
    <dbReference type="eggNOG" id="KOG1515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004893_0_0_1"/>
    <dbReference type="OMA" id="KMRHTIY"/>
    <dbReference type="OrthoDB" id="2336090at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF19">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="147"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="384"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="289"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="641"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="852"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1021"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1161"/>
            <end position="1485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1493"/>
            <end position="1512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="641"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="687"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="731"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="773"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="794"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="811"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="852"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="915"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="951"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1023"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1078"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1208"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1267"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1291"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1348"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1380"/>
            <end position="1395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1416"/>
            <end position="1433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1473"/>
            <end position="1485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1494"/>
            <end position="1512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF11374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1537" mass="165550" checksum="FD5D27623828FCEB" modified="2013-05-01" version="1">MPFNTFGVATAVTPSVIETYFSHYLHRKPLKQKPTAHISYHEGLRLIRQFLDYSAKHSVEDLQAFTAQWVPVPTWVRTQDVEVPPQFLTRSANVIRKQLGSHGLEKVGGEKWWQWRRPESALHAEWIEMKKDHNERKREGRPCDRVILYVHGGAYYFGKMLMRLNGRACVRSVDEHRYQMQRHARKLKARVLAPRYRLAPQFPFPCGLYDCIATYFYLLEHFEPSQILFAGDSAGGGMVLSMLVTLRDQGCPLPAGTILLSPWVDLAHSFPSVAGDGVGDYIPPHGFHHKPSMAWPPPPTTDEDPKKQERKFTQPVDRPFDVVELPATDAAATGSKTSRDKTTELTGEAQAIVEGQDPNTQINQIPGMGPRLEIAIDDKLVIIRQQFQMYAKNDLLAHPLVSPVQQPSLGGLPPMLIQVGGAELLRDEQIYLAHKAANPRQYPPSEAVLDQYDPQRTVLNQYPGTDVQLQVWEDLCHVPHTLSFTRPAKYMYRSVAQFGAWALARAQNRSIEILDDDAVSIISDNEDPNEYGKGSHSFGSIGAEGVTSTQFKLTSIGAVGKAGDDLPPFKDHMIRQRVNRHGVVFPLPLVSEIACLHLDRNTIGAIKSGPVRKWLAKRAESEQKFASEIKKLQKKKLKEMKSYDKMEPGEHPPAAALVNRRTKGSVPGEKKKGKSWGLAMWSGWGSSHDESTIQREEQVNDVKESGIDRPVSKAASTVTLPSAAGFDGVKNTGTANALAGAGSGREARGSATNDKLAVPLSEADEGRRRRRSSASVLTSPWSSKSNGSRSPYRRVKDEGQATNDRDRDSMNVVSPLSSDSASGRGFWDLSRRSSAASMKVNYARPLSTMSTGTLMMSNLNPNSKSGRTNGDDAGVDIENQGRASPTLPAASQARERPSSISEAGKAKGTFKVPGSDNTYLNAGNSRPHNGVVAYPFKVKSTTRDGKVASPDASTTTLDSVKQPDSSRADQDFEMPNAFGVVAHELPTSSGRESSGSAGHKASLVETPVSVLKSENEIIPAPLASQSITPETNTIKSSTRPVSGGIPESTRLSDLDSPEEDIVGPLEPSGSSTHSSSFKTREYRSRDSRLGQLGADGMPTQAWPDKGAPVDSATRPTPAPFKIRNPVFDARVSPAAPVAAAGLQSQQPVSAPFKMRHTIYDTKVAPVGSKPPGQQSEQIPSVHEMPATNGRNAKSKKVKPQPRGQEPHASPSTASRVPSSSESVAVRASKASPSSAELGPAHASKQVNLQPTLDHQAAIPLRSDETNGKLSLNNPLMTTSSRPTASRNSSTGPPPTPPPKDTPPTSPPSTAPIPALPPTSGEEPTHRLSSSSNIIEEYLHFPSTRETGHSSNEFPSLSENLTSAPSSSILHGAGSGAGRPADSLAAEGAAASKSVSENPDSIDLSVAPMPKKELPPGAAAAQAALQAGTGAEQGPTTSPLERSAGPQPTAPLPSLPISQSGPDAATTVPKRQESLPSATKDTTVNIPTYIIGDLSFEHDPGSPMESEKMERAARPQLETFVTANEGIDLKAMTTGNKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M3BWN1</accession>
    <name>M3BWN1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_65515</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760562.1">
        <property type="nucleotide sequence ID" value="XM_016909723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BWN1"/>
    <dbReference type="STRING" id="692275.M3BWN1"/>
    <dbReference type="GeneID" id="27906860"/>
    <dbReference type="eggNOG" id="KOG1290">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_81_2_1"/>
    <dbReference type="OMA" id="QMEGITH"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="44"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="203"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF12441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="421" mass="47259" checksum="E9D26BC8390F90E4" modified="2013-05-01" version="1">MENDSSFAADSCYVPLLDAERLEQYGPGGLHPVHLGDKLQNGRYLIIRKLGHGAFSTVWLARDSSCEHLVAIKIIRSQSARADQELRMHEILLESKMRNLAQDCIVTLLDKFEHIGPNGRHLCLTFPPLGPDITTLFRSSSGARPRLPYELSRQAVKQLLTGLYCLHECRIACGDINFGNLLLTLDQSDLANEEEEELKHPMSKTSVAPSKQQQSHNPKYICEDFPLGEYVEDSTTVKVKLSDLGAAFPFHDPPKQPIVPLALRAPEVILDLEFDHPIDVWSFGCIAFELLIGTPLFAVASSPVMTDDETNDDHLLKMAGTLGPLPPALFSRWPRGQRYFNSKMEITRTDVSDDPVPQAEVYIAPTLETMFMTGKSKEMTMVEARSAIRFLQRALQYEPSARPTISQLMEDPWIKEIEALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M3BWR6</accession>
    <name>M3BWR6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_149142</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760602.1">
        <property type="nucleotide sequence ID" value="XM_016905368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BWR6"/>
    <dbReference type="GeneID" id="27902505"/>
    <dbReference type="eggNOG" id="ENOG502SU1E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095070_2_0_1"/>
    <dbReference type="OMA" id="QAKGIWH"/>
    <dbReference type="OrthoDB" id="4664297at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2970">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF12481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="166" mass="18216" checksum="7C30563C1F50408C" modified="2013-05-01" version="1">MTTPGPQHAREPSVDDLHIFLSHTWQPVPTVKVTIQNTHPTSYMSFLSWDTPVDPSALNTGVLTIVYAVSGEPILGPGLKLNRLLPPPREDIIELAPQETIEVDIDLSAPWIPGDGKLVKVHALGEWRAVWAKGKDEITDEELGAMSGPGVLRGPFRSVRDVEMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M3BXB8</accession>
    <name>M3BXB8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_117285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760842.1">
        <property type="nucleotide sequence ID" value="XM_016901321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BXB8"/>
    <dbReference type="GeneID" id="27898458"/>
    <dbReference type="HOGENOM" id="CLU_2005352_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF12721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="124" mass="13978" checksum="52FA21B0B751F043" modified="2013-05-01" version="1">MPFHICLCIESDLEARQRNEEEQAHMAPQRQSSSMLHRKHTMQRSGPVYAEAISMITIIVVIMLTSVAAVHTVEEPEEVNLLRDSRSQGIQTCLATNTAATRLQNCRSSFIARVLFPGALWQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M3BXE6</accession>
    <name>M3BXE6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PLC-like phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_163813</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760872.1">
        <property type="nucleotide sequence ID" value="XM_016908083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BXE6"/>
    <dbReference type="STRING" id="692275.M3BXE6"/>
    <dbReference type="GeneID" id="27905220"/>
    <dbReference type="eggNOG" id="ENOG502QQ2Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037358_2_1_1"/>
    <dbReference type="OMA" id="IEDWPTI"/>
    <dbReference type="OrthoDB" id="7984201at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF140">
        <property type="entry name" value="PLC-LIKE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26146">
        <property type="entry name" value="PI-PLC_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF12751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="309" mass="35189" checksum="09E3823E8639B46E" modified="2013-05-01" version="1">MMRNWRAALAPGLLDPQPKKPGHRRPVPELYYKRYSEQTFIGTHNAAAVRTKENGYSLSGNQYFNVSAQLNAGVRLIQAQGHRDPQGSNEIRLCHFNCALMDGGTLTSHLLAIRDFLEANPQEIVTLLFVNTGPPLQHWAQAYFDTGLDTISFIAPREKRDRKMRTGDWPSIAELVATNKRLITFLSNGADEDVVPFLLLEFNYLFETNFVNENPDQYTCDASRPWYQRNYVPDMLSLVNHFLYANFLGFRYPNASFADTTNGAGFHVGELGEHAARCRGMYNRRPNFLLVDFFNQGDVFDVEYGMNAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M3BZ05</accession>
    <name>M3BZ05_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Hydroxyethylthiazole kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">SEPMUDRAFT_64131</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = thiamine phosphate + CO2 + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:47848"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62890"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = thiamine phosphate + CO2 + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:47844"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>4-methyl-5-(2-phosphooxyethyl)-thiazole + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + H(+) = thiamine phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphooxyethyl)-thiazole + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24212"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17957"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine phosphate from 4-amino-2-methyl-5-diphosphomethylpyrimidine and 4-methyl-5-(2-phosphoethyl)-thiazole: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">In the C-terminal section; belongs to the Thz kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="17">In the N-terminal section; belongs to the thiamine-phosphate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761432.1">
        <property type="nucleotide sequence ID" value="XM_016909669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BZ05"/>
    <dbReference type="STRING" id="692275.M3BZ05"/>
    <dbReference type="GeneID" id="27906806"/>
    <dbReference type="eggNOG" id="ENOG502QS2M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019943_1_1_1"/>
    <dbReference type="OMA" id="GQTDMPI"/>
    <dbReference type="OrthoDB" id="4994at2759"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004417">
        <property type="term" value="F:hydroxyethylthiazole kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004789">
        <property type="term" value="F:thiamine-phosphate diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01170">
        <property type="entry name" value="THZ_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00564">
        <property type="entry name" value="TMP_TenI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000042">
        <property type="entry name" value="Probable thiamine biosynthetic bifunctional enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000104">
        <property type="entry name" value="Thiamine biosynthetic bifunctional enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00228">
        <property type="entry name" value="Thz_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00097">
        <property type="entry name" value="TMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000417">
        <property type="entry name" value="Hyethyz_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036206">
        <property type="entry name" value="ThiamineP_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022998">
        <property type="entry name" value="ThiamineP_synth_TenI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034291">
        <property type="entry name" value="TMP_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006830">
        <property type="entry name" value="PRK09355.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00693">
        <property type="entry name" value="thiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00694">
        <property type="entry name" value="thiM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20857:SF23">
        <property type="entry name" value="THIAMINE BIOSYNTHETIC BIFUNCTIONAL ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20857">
        <property type="entry name" value="THIAMINE-PHOSPHATE PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02110">
        <property type="entry name" value="HK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02581">
        <property type="entry name" value="TMP-TENI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01099">
        <property type="entry name" value="HYETHTZKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51391">
        <property type="entry name" value="Thiamin phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiamine phosphate synthase/TenI" evidence="18">
        <location>
            <begin position="16"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00061146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00061283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EMF13311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="524" mass="54607" checksum="198EBD5E653865BD" modified="2013-05-01" version="1">MAANTVMAPPEVNYALYLVTDSTPAILGDKDLVAVVKAAVDGGATIVQYRDKTSDTADLVRIAAQLHQVTKAARVPLLINDRVDVALAVGVEGVHIGQDDIDLKSARRLLGPHAIIGVTANSEEEAIAAARDGADYLGIGTVFATPTKENTKSIIGTAGVQLILASLAEKGLDVKTVCIGGINASNAQRVLYQTASKNKNLDGVAVVSAIMGVADAKEAALKLRDLIETPPPFVVSSTKRPLSSDDVIARAPDLVQRLAGRKPLCHNMTNLVVQNFAANVALAIGASPIMSNNGLEAPDLAGLGGALVINMGTVTPEMRDNYLKALSAYNALGGPVLYDPVGAGATQQRRDGVKTLLAGGYFTVIKGNEGEIRTVAGATGFQQHGVDSGASQLSLDERIHLVKATAAREHNVVLMTGSTDVISDGERSLAISNGHPFLGEITGSGCTLGTTIASFLAIEREDPLLAAVTAILMYEIAAERAAVRDDVKGPGTFVPAFIDELYRIRQESVGGNGLWSQTAKIAII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M3BZE3</accession>
    <name>M3BZE3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DUF1682-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_148717</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761532.1">
        <property type="nucleotide sequence ID" value="XM_016905102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BZE3"/>
    <dbReference type="STRING" id="692275.M3BZE3"/>
    <dbReference type="GeneID" id="27902239"/>
    <dbReference type="eggNOG" id="KOG2357">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042570_0_0_1"/>
    <dbReference type="OMA" id="FDGFVWA"/>
    <dbReference type="OrthoDB" id="10039147at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032469">
        <property type="term" value="P:endoplasmic reticulum calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012879">
        <property type="entry name" value="CCDC47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12883">
        <property type="entry name" value="ADIPOCYTE-SPECIFIC PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12883:SF0">
        <property type="entry name" value="PAT COMPLEX SUBUNIT CCDC47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07946">
        <property type="entry name" value="CCDC47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="391"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="391"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="430"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF13411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="440" mass="49482" checksum="0347A274707476F9" modified="2013-05-01" version="1">MAGLLGNLQGVLGGAKSSVTSAASAVDTDDFADFATAAAAPIVQTASSAFDAAATKPTPKGTFSGIGTGLAGRPYTKWYRVWERVTIADFYQELFIIPIIVVVILVNMWGARANKKRAAEWAELHLPHLEQEFAAVGFGAKRADGQPGLLWKEKSKNEYITYATGRQNVAFLDVKLTLYKRYNPMIWMGELAASFFVDSYDAPEERLEATAYAFDGRERSMVPAQAQNQSSQHRDSTFDGFVWAIVHKDKMRKLRNDRYDVSLAVQKDHPKLPQWATVMSEGAEITEALLTPELIKAVTAAGDDLEALIITDQPVDAPRKLNDLVPKKRIELLTRLSTSRAAADLFAYFLRLPDQLVTGAHFRPEALRKVRATREEEIRKIKKIDEDEKALERREASDKLKKEERDRKLSRMSAEEQKKFLEKEKEKTQRKQTKKQTMRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M3C0Y6</accession>
    <name>M3C0Y6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_156104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762067.1">
        <property type="nucleotide sequence ID" value="XM_016907656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C0Y6"/>
    <dbReference type="STRING" id="692275.M3C0Y6"/>
    <dbReference type="GeneID" id="27904793"/>
    <dbReference type="HOGENOM" id="CLU_399649_0_0_1"/>
    <dbReference type="OrthoDB" id="3648169at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF13946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="689" mass="72353" checksum="F8CF3EFC5F583E25" modified="2013-05-01" version="1">MATRISTNLAPLQSWFPSWDCTLECGVADTERGMPTRSKHIPPAESAPDALAKIYTRPCPLSIWTRADDHLSSTSLRSGRLHRMAGLLYCGGLNLAACPTTTTTTTRVTTTGTSSISTFSTSIRASTLLTITIPSSTSASFLLSTSSLRALSSSSTSSSATSSLATVPPLTTSTSRASSSTVNTSTLSPDLVSSTSSSLSSILSESASSLRTATSSSSTARFTSATTFITVSSSTISSPSSAAPTPGNLRCPAANGQTITTGDGSQYLVVCNKDYSPLSQNVFGLNPLLATSYAACLALCSNQGSVCTGITYGFFGGSTIQCNLKTKMLQSNQIPSYTVDSAVRLSGPSGRSEASQLITNGDFSNLDLLSAWKTNSFGVDTSAGAALQQFRTTTFDLARSNGYEAGELIQTVNLAAGLPYYLGFRLRMSLSGTIAPTDYCSFYAQTDSEVLVFFSPNLTDTSGGFASSFNASGTTTGASSRFIFFVYCRGSFTVTWTIDDVVLYTYRPTLGTNILTPPFSTPILTNGDFSNGPTNWNWVATGVTSILKASFGVARVVGLLPQLPLAAVSAGLIMFTTLSPLDTTFNAGYLVQNVLIDPGQTFRITANVVFNISSSCSCDAGIYNTLYAQSGVNGWAWSIFDVTSQRQIAVNVTGTTLASHHLFQMYAGCSGSDPTCTVAFSNVVMYANV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M3C183</accession>
    <name>M3C183_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="7">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_147896</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="7">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="7"/>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762177.1">
        <property type="nucleotide sequence ID" value="XM_016904582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C183"/>
    <dbReference type="STRING" id="692275.M3C183"/>
    <dbReference type="GeneID" id="27901719"/>
    <dbReference type="eggNOG" id="KOG0342">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_26_6_1"/>
    <dbReference type="OMA" id="TQREGCH"/>
    <dbReference type="OrthoDB" id="193716at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="109"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="337"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="604"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="700"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF14056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="711" mass="78695" checksum="DE36F004570905A1" modified="2013-05-01" version="1">MRRAFQRCSASLTRPLSSTLTSTSRATQQCLRTKGFLSRQISITFPATRNLHQSSRLRDAATEQSMPTTEPITRFKDLETHNIVHPNIVRALTEHMGLETMTEVQTRTLNEAIKGVDVIAQARTGTGKTLAFLLPILQRIINDDPSIAERGHGRRGRHMTADDIRGLIISPTRELAEQIAVEAKKLCRNTGVIVQTAVGGTQKSAGLRAIQREGCHLLVGTPGRLKDILSDRDSRVEAPDLQALVFDEADRLLDQGFWPDVQDIMRLLPDTVEKDRQTLMFSATLPKEVVRIVRSTLKPGFNFVKCVRDDEEPTHVRVPQKSVSLVGLENCVPALIELCQRAIEASRSSGTRPYKAVVFFNSTAEVTLATSVLLGLREESAQHADNVGRGKGAHPWYPIRIFEIHAKLSQQQRSRAADDFRSAQSGILLSSDVTARGMDFPDVTHVIQIGLPPSREQYIHRLGRTARAGKEGEGWIFLNPVDQAEARSRLRDLNLTKDDTLQIPKMDLTQPADVPAYAGRILSMYQNAIKSVALSEKTKVYLAQFGIYQWFNRKQQLVHMINNLSRFGWGLSTPPCVPPGLAARLRLKKLEGIVVGEDLLSLPEDRRGEFGSSGRGEYTPRESASGSSFGNRGGDGGEYQPRRPSYGRDGSSYSNRGDRNSSFGDRGGRSSYGGGRGRSNYGGERGRSNYGGERGNYGRGRPERSEASGFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M3C350</accession>
    <name>M3C350_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_140431</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762827.1">
        <property type="nucleotide sequence ID" value="XM_016902937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C350"/>
    <dbReference type="STRING" id="692275.M3C350"/>
    <dbReference type="GeneID" id="27900074"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_13_8_1"/>
    <dbReference type="OMA" id="LATAIWC"/>
    <dbReference type="OrthoDB" id="2533084at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF187">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17840)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="322"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="401"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="430"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="466"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="498"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF14706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="534" mass="59601" checksum="D46FAF7D7830BC93" modified="2013-05-01" version="1">MPVGINITMSRVNETRATSSAGLSNGDLPFDLEATGEEQGYILDVEVLKNVAPNWEQYQLTQDGRTVLIPQPTTDVDDPLNWTWTKKHIVLLVVAATSFLPDYGSATGAVTLLPQAKIWNLPEDTVNHSQVGNVFMVGAGAVVVVALSAFFGRLPILFWFTVMAVWTAAGCAVDNGFDTFMAFRILNGFFSTVAQGGGMMFIKDMFFVHERARKINIWASFVILSPYAGPLIAAFIIEKHKWELAFQIYTIMTALCLLAIIFLGDETFYHRKIAAAERPVRQRGVAGQISRLVGVEQFRTRHLRNTFVQACMRSVHVMLKPTVFISCVWYLFVFAWVVGINTCLSMFVTPLYNFGPRQIGFFYFTPIIAATIGEIVGRWLHDFLADWHSRRSPGGRLKPEYRLTAITFATPFMVVGIIVLGFALEEGYHYMVAALGWGLFVFGIMVSTVAITSYNLDCYPEGSGEVAAWLNFARTAGGFIISYFQVRWANAMGTKKSLGIQAAVVFTAWFLILFLQVFGEKLRKMSGPLRFKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M3C3C5</accession>
    <name>M3C3C5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-hydroxy-3-methylglutaryl coenzyme A reductase</fullName>
            <shortName evidence="9">HMG-CoA reductase</shortName>
            <ecNumber evidence="9">1.1.1.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_63486</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(R)-mevalonate + 2 NADP(+) + CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15989"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.34"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Endoplasmic reticulum membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the HMG-CoA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.34" evidence="9"/>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762907.1">
        <property type="nucleotide sequence ID" value="XM_016909641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C3C5"/>
    <dbReference type="STRING" id="692275.M3C3C5"/>
    <dbReference type="GeneID" id="27906778"/>
    <dbReference type="eggNOG" id="KOG2480">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001734_0_0_1"/>
    <dbReference type="OMA" id="KKWIMRA"/>
    <dbReference type="OrthoDB" id="310654at2759"/>
    <dbReference type="UniPathway" id="UPA00058">
        <property type="reaction ID" value="UER00103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004420">
        <property type="term" value="F:hydroxymethylglutaryl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015936">
        <property type="term" value="P:coenzyme A metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="CDD" id="cd00643">
        <property type="entry name" value="HMG-CoA_reductase_classI"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="1.10.3270.10:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
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    <dbReference type="Gene3D" id="3.90.770.10">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl-coenzyme A Reductase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="HMGR, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.420">
        <property type="entry name" value="Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="HMG-CoA_N_dom"/>
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    <dbReference type="InterPro" id="IPR002202">
        <property type="entry name" value="HMG_CoA_Rdtase"/>
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    <dbReference type="InterPro" id="IPR023074">
        <property type="entry name" value="HMG_CoA_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023076">
        <property type="entry name" value="HMG_CoA_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004554">
        <property type="entry name" value="HMG_CoA_Rdtase_eu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023282">
        <property type="entry name" value="HMG_CoA_Rdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009023">
        <property type="entry name" value="HMG_CoA_Rdtase_NAD(P)-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009029">
        <property type="entry name" value="HMG_CoA_Rdtase_sub-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00533">
        <property type="entry name" value="HMG_CoA_R_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572:SF24">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00368">
        <property type="entry name" value="HMG-CoA_red"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="HPIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00071">
        <property type="entry name" value="HMGCOARDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55035">
        <property type="entry name" value="NAD-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56542">
        <property type="entry name" value="Substrate-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00066">
        <property type="entry name" value="HMG_COA_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00318">
        <property type="entry name" value="HMG_COA_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01192">
        <property type="entry name" value="HMG_COA_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50065">
        <property type="entry name" value="HMG_COA_REDUCTASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0521">NADP</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="278"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="490"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="11">
        <location>
            <begin position="249"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="645"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1125"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1133"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1145"/>
            <end position="1155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00007661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF14786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1155" mass="124273" checksum="DF3CF7B2AA3F14E6" modified="2013-05-01" version="1">MLGNLVPTRWRRSHNITDPNKPAKYNAAITPYLQTASRKACTHPIRTIALVAILASAFYVNLLETGFFRPQTAANKVDFNALSAGTRRLHLGQDTAWQWQVEENGSPKVYRAREKELALVTLDFLDTGNASPKAVPSPQDFDVDGVDLNVLPPSENILSGLSSARSLVFSLPLDQAASFLEHSREISAEGGWETDSSASNDDDEEGEQKKWLMTMAKTPAASGSGSMVEWAQNSWSAFLDLLKNAETLDIIIMTLGYLSMYLTFISLFLSMRRLGSNFWLGTTTLFSSAFAFLFGLLVTLKLGVPENVVLLSEGIPFLVVTVGFEKPIMLTQAVLSASVQAKNSAANGEGLTIQNAVQNAVQQAVRERGFEIVRDYAIEIAILCAGAASGIQGGLRQFCFLAAWTLFFDCILLFTFYTSILTIKLEINRIKRHVALRKALEEDGVSRRVAEKVASSNEWPNGNKLGDAGDNNNWINIFGRKARDSSVPRFKLLMVTGFIAINVANLCTMPFRGHRHHVPPVTTAGLSSVVSSPPQDPFKVAGNGLDFLHQEAHQSEQPLSVTVFNPIKYDLQYPSVHYAALSDDWTSVNGDFPQGLFQALGGRVVESLLKSFEDPVLSKWVISLLAISLVLNGYLFNAARWTIKDPGQDDTDREEAVTEAPKANGHVPSPIKTHKPVEEVAPPVSPTALDGSRKRTREECEAMLRAKQAPQLNDAELVDLAVRGKIPGYALEKTLEDKTRAVKIRRSLISRTPATADLTAKLERSLLPYENFDYDRVHGACCENVVGYMPLPLGVAGPMTIDGKSYFLPMATTEGVLVASTSRGAKAINAGGGCITVLTGDGMTRGPCIGFETLTRAAAAKVWLDSADGQKVMKDAFNSTSRFARLQSLKTSIAGTYVYVRFKTTTGDAMGMNMISKGVEKALGVMSTEAGFSDMAIISVSGNFCTDKKPAAINWIDGRGKSVVAEAIIPGDVVRDVLKSNVDALVELNISKNLIGSAMAGSIGGFNAHAANIVTAIFLATGQDPAQNVESSNCITVMKNLHGNLQITVSMPSIEVGTIGGGTVLEPQAAMLDLLGVRGAHPTTPGANSQQLARIIAAGVLAGELSLCSALAAGHLVKAHMAHNRSAAPSLAPTRSSSPSRGTSWPLSMTTTRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M3C4A5</accession>
    <name>M3C4A5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_14514</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EMF15106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016903093.1"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_211837_0_0_1"/>
    <dbReference type="OrthoDB" id="5022336at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF15106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="57" mass="7017" checksum="B283F8920F90ABBE" modified="2013-05-01" version="1" fragment="single">IVRSLIYTILGTRLDLVFSMLIASRYYLNLLKKYYEQIKRILRYVLEILETRLEYSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M3C4F3</accession>
    <name>M3C4F3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DUF862-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_154054</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeSI family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763287.1">
        <property type="nucleotide sequence ID" value="XM_016907544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C4F3"/>
    <dbReference type="STRING" id="692275.M3C4F3"/>
    <dbReference type="GeneID" id="27904681"/>
    <dbReference type="eggNOG" id="KOG0324">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0907">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_306981_0_0_1"/>
    <dbReference type="OrthoDB" id="21221at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070646">
        <property type="term" value="P:protein modification by small protein removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="entry name" value="PPPDE domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013535">
        <property type="entry name" value="PUL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378:SF7">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08324">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01179">
        <property type="entry name" value="DUF862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51858">
        <property type="entry name" value="PPPDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51396">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032285" evidence="5">
        <location>
            <begin position="29"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="domain" description="PPPDE" evidence="8">
        <location>
            <begin position="386"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="531"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="PUL" evidence="7">
        <location>
            <begin position="679"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="534"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF15166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="964" mass="106767" checksum="2862E8C7B879DB12" modified="2013-05-01" version="1">MVKLHQGLPRLTTAISVSLLILLTATHARPVDEVADDTIRQWNATEPHRLEQRWIQCDWAHIATIVTQPLQDSDDHCTLAAKKGHRLVCMMVNPTTQRSVYQEARELAFYGYMSQVTANDIQPGLGNINEALRGAGLTDEPTQWFYLNQWHVRDSGDFPSTNAFFQNHASPAQGAIIAFNNKNPEMMNHDSLSRTLDADQVVPLKQWSDVFFLGWKEACRASRGGVANMRRLEHVFRDNVINQGTIEVLRSIVGKDYLGVRDMWPGFQYSFGDVRMRAALGTPNGNGLAWLVGQHQAEIGKKIVDRVHIFNCQTSPLALVSCDACSVVLLSTSGRKSHQSPYQTIFSILLPTCQNNQLPPRHETLAKRQHQHGLTTSRGRPQTEKMEVELYVYDLTRGMARSMSRQFLGIQIDAVYHTALVFNNIEYFFGQGVQTCYPGTTHHGQPMEKIALGKTELPLETIMDYLESLKQIYTAESYDLFAHNCNNFTNDFAMFLVGCGIPDHITSLPAKVLETPFGQMLKPQIDASMRQMTQAPVPPQNIPPAVSRSALNTSSSGHAAGPAKHQSSDRYGQVVNLTDANALDTHMAGAADSCTTVFFTSSTCAPCRLAYPMFDRLAEEHAQALFVKVDINSAREIGSRYQIRVTPTFMTFSKGKKQDEWSGADPNLLKANVELLIQTTFPPHPHMTLKVPALQYGSMKPYVFGKIPPLDKLMGKLGSAADHKDITSLRTFVEKRGANPQDAAVPDLHSIAHTFKTDVIALPVEVRFAAVDLLRCAMIDARVSGFFAEDSPVRTMAVMIEHVNNLPDCPHNLRLVTLQLACNIWSSSLYVKEIMASDDTTISNLIQLITSSLLDASHPTTRVAAGSLAFNLAVSNYRVRREQNEEALAEGEQVELAASILESLVEEKSEDAAKVLLLALGYLVYCAPENGELADLCKAMGAKKTVRGVKAHAKLGQEIASLLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M3C4J6</accession>
    <name>M3C4J6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_130956</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763342.1">
        <property type="nucleotide sequence ID" value="XM_016902387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C4J6"/>
    <dbReference type="STRING" id="692275.M3C4J6"/>
    <dbReference type="GeneID" id="27899524"/>
    <dbReference type="eggNOG" id="ENOG502RYQC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_3_0_1"/>
    <dbReference type="OMA" id="WTMGGQP"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178:SF5">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178">
        <property type="entry name" value="MONOOXYGENASE, FAD-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="148"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF15221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="414" mass="44117" checksum="B7BF52D288A3D6BD" modified="2013-05-01" version="1">MASTTRKPILISGAGLASLLLARSLLRSSIPFLIFERDQSISFRGQGYRLRLSAEGLDAIENVLGPGPTGFPRFWDKCGKTGGARGFGAIDALSGEDITDMLEKEKEKEPENKSKPSKDMLSSRDGKTIGISRGDMRALFLEGCEPYVKFGHQVTGYESTSNGVHAVFKDGSKSVEGDMLVAGDGIYSKIAKQVSDGKLKTFDTGARGIHGQAPTTAFKQLGEGVWRILDNSNPNGKVFVITNVRPGDMDDESLEFGWTMAGQPGVIKPANDDNVAAMIGKPAAEIAKTLTAKWHPRVKSLFTQMNDSEAAFWKITCSTPSGVPEWTNASRVTVMGDAAHSMTPAGGIGANTAVRDSALLGKLLSEAGGWTEGITAAYEKEMRIYASEAVATSYAMATSQFGVTIDEKTSPVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M3C8Y5</accession>
    <name>M3C8Y5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal_L31e-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_152020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL31 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756451.1">
        <property type="nucleotide sequence ID" value="XM_016907193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C8Y5"/>
    <dbReference type="STRING" id="692275.M3C8Y5"/>
    <dbReference type="GeneID" id="27904330"/>
    <dbReference type="eggNOG" id="KOG0893">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112570_1_1_1"/>
    <dbReference type="OMA" id="EVWKQGI"/>
    <dbReference type="OrthoDB" id="9739313at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00463">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.440.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000054">
        <property type="entry name" value="Ribosomal_eL31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023621">
        <property type="entry name" value="Ribosomal_eL31_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956:SF0">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01198">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01380">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54575">
        <property type="entry name" value="Ribosomal protein L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF08330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="129" mass="14603" checksum="18FAECECA0C14D51" modified="2013-05-01" version="1">MSNKTKEQKPAKGGRSAIDDVVAREYTIHLHKRVHGVSFKKRAPRAIKEIRFFAEKAMGTSDVRLDPQLNKKVWESGIKGVPFRLRVRISRKRNDEEGAKEKLYSYVQAVNVKNPKGLQTTVVDEAATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M3CAI9</accession>
    <name>M3CAI9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Vacuolar protein sorting-associated protein 51 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_166501</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN).</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the Golgi-associated retrograde protein (GARP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the VPS51 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756981.1">
        <property type="nucleotide sequence ID" value="XM_016908237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CAI9"/>
    <dbReference type="STRING" id="692275.M3CAI9"/>
    <dbReference type="GeneID" id="27905374"/>
    <dbReference type="eggNOG" id="KOG2346">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043566_0_0_1"/>
    <dbReference type="OMA" id="YNLKPPG"/>
    <dbReference type="OrthoDB" id="203678at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990745">
        <property type="term" value="C:EARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014812">
        <property type="entry name" value="Vps51"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15954">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15954:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="2" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU368010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF08860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="251" mass="27803" checksum="2698A9B508CE127C" modified="2013-05-01" version="1">MSIASPRPSISSRRTSVDTISSPTSKSASQAAERGSLRRNRTALRDYYNLKAAQQSSDQEPTTPTLDPDQESELDKPGFEPEQYVRNLLSSEDLYGVLKIEAGLVSDIRNLDGEKKALVYDNYSKLITATNTIRFLREKMDPMMPGTTTLIPAIGHIAETAAGLKKDMQDAHGTDGHAANAGEEKRKQQQTVRWVLQSPERISEMMSDGRDDEAKAEWEKVEKLLQKWHGVKGVDNVRKACLAALDNAEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M3CCS8</accession>
    <name>M3CCS8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_151213</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758338.1">
        <property type="nucleotide sequence ID" value="XM_016906675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CCS8"/>
    <dbReference type="STRING" id="692275.M3CCS8"/>
    <dbReference type="GeneID" id="27903812"/>
    <dbReference type="eggNOG" id="KOG0022">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_14_1_1"/>
    <dbReference type="OMA" id="ACLDCHY"/>
    <dbReference type="OrthoDB" id="1560166at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43350:SF18">
        <property type="entry name" value="ENOYL REDUCTASE (ER) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43350">
        <property type="entry name" value="NAD-DEPENDENT ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="8">
        <location>
            <begin position="33"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="7">
        <location>
            <begin position="209"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF10217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="385" mass="40315" checksum="4147C41C6E026002" modified="2013-05-01" version="1">MSSQKYTIPAKGIVAYDQHSWKLENLLTREPLEDEFLVEMIATGVCHTDISGYGGIYPRVLGHEGAGRILKLGSRAQEAKWKVGDLVILSAAACLECLYCTTGHPAYCVQHAALTLAANEPNFILAEGAAAAADKGKVIGGGYFGQSSFASPTPVKVSAAANVTKLIKDAEELKLYAPLGCGIMTGAGAITHVGKCGPDDVVAVIGLGGVGLAGICAAVNNKVGTIIAVDINPGRVELAAELGATKGLLSTKEALGDKTLSQAIKDMSPQGLGATAVLDTTPSVAILSECLGAIRKNGMVLQVGVKPVDAKLEVDCLQHMVNGRRLVGVIEGDRDPAEALPELVQWSKDGILPVGKMFKEFPLQEFEEAKKKMEEGSVIKSVLIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>M3CCU7</accession>
    <name>M3CCU7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_151230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758358.1">
        <property type="nucleotide sequence ID" value="XM_016906684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CCU7"/>
    <dbReference type="GeneID" id="27903821"/>
    <dbReference type="HOGENOM" id="CLU_1023662_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004031901" evidence="1">
        <location>
            <begin position="24"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF10237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="272" mass="30301" checksum="90590512D3018A89" modified="2013-05-01" version="1">MQSPLFIVAFIGILMCRYIYVHAQTDDGSDDNSWLDYGSFCQCITLHAHDHFHPQDNVTAKVCNDINGTTNDWPADKNSISFLKHCDFDFDDAEAAVTTFAESCRTADQEYFHLNVTGAQCCPKGDGACQGDNTPPPEEIPPPTNKTEKRQDEDYFVDKTAFCQCSQAFPNETFYAVKVNTYEVCDWYNQTGGAIDVPKYTTESEGTIAHCQFPDAEKSIDQFSQDCRNVDKYLFQGVTGAQCCPKGDGACVANNTGIDDTTSTPMKKYMFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M3CFC2</accession>
    <name>M3CFC2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyltransferase family 32 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_125693</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760639.1">
        <property type="nucleotide sequence ID" value="XM_016902004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CFC2"/>
    <dbReference type="STRING" id="692275.M3CFC2"/>
    <dbReference type="GeneID" id="27899141"/>
    <dbReference type="eggNOG" id="ENOG502R7TT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022381_2_2_1"/>
    <dbReference type="OMA" id="VTWDLFH"/>
    <dbReference type="OrthoDB" id="409543at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.20:FF:000004">
        <property type="entry name" value="Glycosyltransferase family 32 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039367">
        <property type="entry name" value="Och1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834:SF8">
        <property type="entry name" value="TRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004031832" evidence="3">
        <location>
            <begin position="28"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="354"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF12518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="413" mass="47528" checksum="8760332319DEF1EE" modified="2013-05-01" version="1">MPKQLQRTIPAVLALCLLVFFLSGSHSTFTPAFFESRPKHFPRKIWQTWKVDPLKFEERDHNVAQSWIAKNPDYRYEVLTDLNDMAYVETHFGPDGLDREDIVYVYRELTARIIKADLLRYMIMYIEGGVYTDIDVEALRPISNFIPPRWKEADVDMVVGIEIDQPEFDKHPVLGTKCKSFCQWTFMCKPKLPVMMKLIENIIVWLRSVAVQQGVPISEVKLDFDQVISGTGPSAFTNAILDDIEQRTGEKVSWDAFHDLSESTLVGGVLVLTVEAFAAGQGHSDSGTHETKQALVKHHYHASGWPTTHPRFNHPIFGEVEKCNWNHECVKKWDEDTAAFEALSPEDKIKQVALKEADDKRKADEEERRKVEAEERKKKGLPELKYDDKGQVIIPDEEKKDEPKEPAKDLHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M3CGZ7</accession>
    <name>M3CGZ7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin carboxyl-terminal hydrolase 19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_148487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761219.1">
        <property type="nucleotide sequence ID" value="XM_016904949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CGZ7"/>
    <dbReference type="STRING" id="692275.M3CGZ7"/>
    <dbReference type="GeneID" id="27902086"/>
    <dbReference type="eggNOG" id="ENOG502RVVW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019318_0_0_1"/>
    <dbReference type="OMA" id="REDIWRV"/>
    <dbReference type="OrthoDB" id="5369841at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="562"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="506"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="584"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="605"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF13098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="641" mass="67868" checksum="CBFC2B77CA2763D0" modified="2013-05-01" version="1">MDPQSQSFTPSFNTITTTNSNTSTGVSSDHWRLQTDIVRVQQIQAEHSERIARLERKQDDDARMKSVWGTQSPFPSVLSGTPQHGPLQQPLPDRFANFDDEANNLMSSLHLDAEEEPRSRALGATSRANSVRFDESANQNHFSHSSRPSMDSFSRTNSGLGGLQMTERTSSHKSEGRASSVHSMRSAASGRASSLNLETAAYGLDSLRSPMEMPGLAPGLLLLGAVPAVIRCWMNTNFKHDALLYAAVCTGSYKSFLDLRLIRKLGFENVIAASGDGYRTVELPIYFPEAVPHPASSRSGSPAPQLPSLRVEFRVIEQDGQDNDDKAIQIFIGSDVLRAHNADILFSSNSMTLYDDERSKLSIPLSRPENAAAFNTLYVTSGSTWSGNVPAKTQVTPERATYLNGLGGDSSTASISSAAASPPLGKYRPPGALAAESGAIDANRAVGIIGSDPDTRSTTSSRPSLAMLNTSSEREETSSEAGASMSTPAKSAGTPAIWSSWRRDGPGTASSATASSSPSVGILDWANAGRNREVAYQRKETGIKVLKPKTAVRSFSTTSATAVSGTASPPIALTSTPTTSGEGSKSRFFDDGRRINGGSGGGSSEKVTAANTKENTGSSSGTIKTKANPIGGASAFSWLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M3CH25</accession>
    <name>M3CH25_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Membrane-associated proteins in eicosanoid and glutathione metabolism</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_148499</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761239.1">
        <property type="nucleotide sequence ID" value="XM_016904959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CH25"/>
    <dbReference type="STRING" id="692275.M3CH25"/>
    <dbReference type="GeneID" id="27902096"/>
    <dbReference type="eggNOG" id="ENOG502S4G7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134926_0_0_1"/>
    <dbReference type="OMA" id="SHANFVE"/>
    <dbReference type="OrthoDB" id="19091at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35814">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35814:SF1">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF13118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="152" mass="16014" checksum="B3DF71B81D30D443" modified="2013-05-01" version="1">MSARLGLGLGLPVTTTFALPLSLYYVFLQGRVVQQRIKANQAISQSSSPTAGEDDGLLVACRAQGNFNENVPLALLLAGFVEANGGSRKVLTWALAALTLARVIHVEAGLLVHGKKHAHTGPGRPIGFFATLGVELGLAGYGAYLVKEYWGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M3CMW3</accession>
    <name>M3CMW3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Abnormal eversion of vulva protein 20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SEPMUDRAFT_147113</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">GTP-binding protein that functions in embryogenesis, cytokinesis, germline development and microtubulule cytoskeleton dynamics.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763269.1">
        <property type="nucleotide sequence ID" value="XM_016904088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CMW3"/>
    <dbReference type="STRING" id="692275.M3CMW3"/>
    <dbReference type="GeneID" id="27901225"/>
    <dbReference type="eggNOG" id="KOG0073">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040729_12_3_1"/>
    <dbReference type="OMA" id="KTHHWQI"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04154">
        <property type="entry name" value="Arl2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000981">
        <property type="entry name" value="ADP-ribosylation factor-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045873">
        <property type="entry name" value="Arl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044612">
        <property type="entry name" value="ARL2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45697">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="9 15 17" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0519">Myristate</keyword>
    <keyword evidence="8 15 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="21"/>
            <end position="28"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="123"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00055307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00077919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMF15148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="181" mass="20884" checksum="4B40FF830854A32E" modified="2013-05-01" version="1">MLSILRKARLKDKEMRILMLGLDNAGKTTIVKKIMNEDVNEVSPTLGFIIKTIEYEGYKLNIWDVGGQKTLRTYWKNYFEKTDTLIWVVDATDKERIEDCRQELTGLLVQERLMGASLLVFKNKSDVAGCMTEDDIRKGLQLDNIQTHKWHILPCSAMTGLNLQAGLQWVVQDAKDRLFLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M3CPI2</accession>
    <name>M3CPI2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">precorrin-2 dehydrogenase</fullName>
            <ecNumber evidence="2">1.3.1.76</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_147478</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>precorrin-2 + NAD(+) = sirohydrochlorin + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15613"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58351"/>
            <dbReference type="ChEBI" id="CHEBI:58827"/>
            <dbReference type="EC" id="1.3.1.76"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; siroheme biosynthesis; sirohydrochlorin from precorrin-2: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.76" evidence="2"/>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763774.1">
        <property type="nucleotide sequence ID" value="XM_016904322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CPI2"/>
    <dbReference type="STRING" id="692275.M3CPI2"/>
    <dbReference type="GeneID" id="27901459"/>
    <dbReference type="eggNOG" id="ENOG502RYIW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011276_8_5_1"/>
    <dbReference type="OMA" id="TQIWKLC"/>
    <dbReference type="OrthoDB" id="1721126at2759"/>
    <dbReference type="UniPathway" id="UPA00262">
        <property type="reaction ID" value="UER00222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043115">
        <property type="term" value="F:precorrin-2 dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3280.10">
        <property type="entry name" value="Siroheme synthase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028161">
        <property type="entry name" value="Met8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028162">
        <property type="entry name" value="Met8_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028281">
        <property type="entry name" value="Sirohaem_synthase_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006367">
        <property type="entry name" value="Sirohaem_synthase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01470">
        <property type="entry name" value="cysG_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35330">
        <property type="entry name" value="SIROHEME BIOSYNTHESIS PROTEIN MET8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35330:SF1">
        <property type="entry name" value="SIROHEME BIOSYNTHESIS PROTEIN MET8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13241">
        <property type="entry name" value="NAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14823">
        <property type="entry name" value="Sirohm_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14824">
        <property type="entry name" value="Sirohm_synth_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75615">
        <property type="entry name" value="Siroheme synthase middle domains-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Siroheme synthase central" evidence="8">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Siroheme biosynthesis protein Met8 C-terminal" evidence="7">
        <location>
            <begin position="163"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF15653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="252" mass="28069" checksum="DCB28B1637A8A6E3" modified="2013-05-01" version="1">MAGEKFPAIEGGGSLILAWQVRNKKVLVVGGGEVAAGRILNLLNADAKVLLVSPREGLNPEVAYRVEQKQVEYIDRVFQPWDLDDPDISMVLTAIDDPDASSRLWKLCKKKGIPANIADVPPECDFYFGSVHRDGPLQIMVSTNGNGPKMANIVRRRIAGNLPPNMGDAIKKVGKLRRRLREMVPEVEAGPKRMGWMSKVCVQWSLEDLCEMDEDDMEKLLQYYAPDQVPSFTDVRGPPWEFDGSFGWACVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2022-12-14" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>M3CPY9</accession>
    <name>M3CPY9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_147581</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763909.1">
        <property type="nucleotide sequence ID" value="XM_016904391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CPY9"/>
    <dbReference type="GeneID" id="27901528"/>
    <dbReference type="HOGENOM" id="CLU_2470503_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF15788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="88" mass="10091" checksum="038A8AEBD21C40EC" modified="2013-05-01" version="1">MIMIMVYIRMSQETNMADPKRAEDRQAFNVCTAACERVPQEAPLTLLSARFGSTSYEDTRTTHWRMANGDGWWVVVVVVVVVLENHCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M3CUP6</accession>
    <name>M3CUP6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_18766</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456292">
        <property type="protein sequence ID" value="EMF07887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756008.1">
        <property type="nucleotide sequence ID" value="XM_016908308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CUP6"/>
    <dbReference type="GeneID" id="27905445"/>
    <dbReference type="eggNOG" id="ENOG502SCZR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_162820_0_0_1"/>
    <dbReference type="OMA" id="IDRCAAY"/>
    <dbReference type="OrthoDB" id="5355526at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF07887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="71" mass="8101" checksum="FEE31387FED100A1" modified="2013-05-01" version="1" fragment="single">MCIQVIERYSICKCLYYKHAVDPCPSTRQRGHVLREKTVLVGYACETHSRSRAIQAYLHSLPVQPDSGYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M3CWE0</accession>
    <name>M3CWE0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transmembrane emp24 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_152097</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756558.1">
        <property type="nucleotide sequence ID" value="XM_016907241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CWE0"/>
    <dbReference type="STRING" id="692275.M3CWE0"/>
    <dbReference type="GeneID" id="27904378"/>
    <dbReference type="eggNOG" id="KOG1690">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066963_2_1_1"/>
    <dbReference type="OMA" id="GATCAWQ"/>
    <dbReference type="OrthoDB" id="3427at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032657" evidence="8">
        <location>
            <begin position="18"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="9">
        <location>
            <begin position="27"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF08437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="220" mass="25343" checksum="C68C9DD6A6D7208F" modified="2013-05-01" version="1">MRSIFSSLALFMSCAEALYFFIEGPTQKCFFEELPKDTLVVGHYKATQYRPNSMQYETVPDMGVFISVDEVFDNEHRIVSQRGRSDGKFTFTAADSGQHRLCFTPTNLDKVNAPDRHGEHVGAVKFELDMAIGETSQIERSDKEKLGEVAQKVKDLNARLQDVRREQIFQREREAEFRDQSENVNSRVVRWTLVQIAVLGVTCAWQLSYLRAFFIKQKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>M3CWF1</accession>
    <name>M3CWF1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_152312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF07996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756117.1">
        <property type="nucleotide sequence ID" value="XM_016907369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CWF1"/>
    <dbReference type="GeneID" id="27904506"/>
    <dbReference type="HOGENOM" id="CLU_2499299_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF07996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="86" mass="9375" checksum="34EF2AAB51B2D7F3" modified="2013-05-01" version="1">MIGTDKTNPLHVDSGTSYRSHVPGDPSLAASESFSAQERQQGVLSSIVQASSHNALVPEIRENARERSMGSHSHLQDNTWPWHAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M3CX65</accession>
    <name>M3CX65_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class I glutamine amidotransferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_158859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756828.1">
        <property type="nucleotide sequence ID" value="XM_016907810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CX65"/>
    <dbReference type="STRING" id="692275.M3CX65"/>
    <dbReference type="GeneID" id="27904947"/>
    <dbReference type="eggNOG" id="ENOG502S8W8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_44_1_1"/>
    <dbReference type="OMA" id="LVEFITC"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052158">
        <property type="entry name" value="INH-QAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130">
        <property type="entry name" value="ARAC-FAMILY TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130:SF3">
        <property type="entry name" value="HTH-TYPE TRANSCRIPTIONAL REGULATOR RV1931C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="1">
        <location>
            <begin position="215"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF08707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="334" mass="35603" checksum="42EA49AFDFA2A12F" modified="2013-05-01" version="1">MNMFASRSLRSFARNANCRISTNAIWQHNISTTTTTTMTTGTIGTSPVTAAAGMGRRGELSGAFRSGRACRSLTTGHVKQRQVPPPMSSSPPPIQVLALAFQGLNILDLTGPAEVFGNSALRPAFNLTIASATPQNPRATKSAEGVTIASDTSFQHLLQENAAQLARYDILVVPGAPPEDIECALKNDSGLLEVVKTFAGLPPKATAVQKQGEGEVAAKDRWLFSICTGAAFLGTEGVLGKKKATTHFAYLPILEEMTEKAGAPAEVVRKRWVDAGRTESGVRVVTSGGVSCGIDAALWILSHQVGLEKAKEVAEIMDYDWKFGENGFTKEWIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M3CXQ2</accession>
    <name>M3CXQ2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_121217</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756557.1">
        <property type="nucleotide sequence ID" value="XM_016901671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CXQ2"/>
    <dbReference type="STRING" id="692275.M3CXQ2"/>
    <dbReference type="GeneID" id="27898808"/>
    <dbReference type="eggNOG" id="ENOG502TJBK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_877625_0_0_1"/>
    <dbReference type="OrthoDB" id="3629740at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF2">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF08436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="36940" checksum="1F7138283FD39018" modified="2013-05-01" version="1">MADIHMSDLYNPQMLIIRIEDNDSIFRVPRGLLCAKSAYFESAFRRETFKEGREHLIELSSDVAEWVLEVCLSARICDIGHDEQHPMSQHCSKNVANRIQCFIGWLYTQRIFWQPLPHEPKQCRYEVNLVHSDDEDDPSNPVTWPWEVIIQLYVFGDRYDTKAFRNAIMDVALLKALQFQPRSYLWPDVKDQELAYKRLPSNSDLYRLMLDIGVHEIEPTFSAIQSPAEALGLHLPAEALAILYCLSSRLAAKLRCPACQARRHCGRDHATMPLRATFRTDFTSYYEHDSEEEVHACIKKWTELAYKHKLDMVSYEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M3CY67</accession>
    <name>M3CY67_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GPR1/FUN34/YaaH-class plasma membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_151872</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF09007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757128.1">
        <property type="nucleotide sequence ID" value="XM_016907095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CY67"/>
    <dbReference type="GeneID" id="27904232"/>
    <dbReference type="eggNOG" id="ENOG502RQUV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051062_4_0_1"/>
    <dbReference type="OMA" id="FMICATR"/>
    <dbReference type="OrthoDB" id="3648309at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051633">
        <property type="entry name" value="AceTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF4">
        <property type="entry name" value="PROTEIN ALCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF09007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="29607" checksum="D447BB0856E488CB" modified="2013-05-01" version="1">MDSKDMENGRVGQVTPPNDMGDLRQMLTSKSITDEQFERLFLSPRNVRAAPLKGFANPTPLAVMGFATALTPLSAQLMGWRGSGGAAQASVGASLTFGGGLLILAGIGEFLLGNTFPFLVFMGYGCHFLTFAITFIPFFNAVSAYTSGSPYLGEMNQEQTAGFANSFGFYPMSLAMLSLVFLLCSLRTNLIFFLIFVAATIGFSFASASFWFAGIGQMANSAKFLVATGACFWTCAMLGWYLLLAIMIPTMELPIPTPPVVDLSQIIKAKPPKAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M3CY74</accession>
    <name>M3CY74_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA/RNA-binding protein Alba-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_152251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756757.1">
        <property type="nucleotide sequence ID" value="XM_016907330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CY74"/>
    <dbReference type="GeneID" id="27904467"/>
    <dbReference type="eggNOG" id="ENOG502SW4P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137478_0_0_1"/>
    <dbReference type="OMA" id="MTIYISR"/>
    <dbReference type="OrthoDB" id="424402at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002775">
        <property type="entry name" value="DNA/RNA-bd_Alba-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01918">
        <property type="entry name" value="Alba"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/RNA-binding protein Alba-like" evidence="1">
        <location>
            <begin position="19"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF08636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="170" mass="18248" checksum="DBF620748E17232E" modified="2013-05-01" version="1">MEFEESSLRGMYDLVTLGVAGGTQISSRTSAVLAKLLSTTTTGDETTKTSIVALTATSKAASKLISIVEIAKRELLARGQKVYQYNALGSRMTEIPRRTHVETVVTAENPAEEESDESEEDAFEVMGGVVAAAAPGQESEGMKKRNIPTLKIYLSTVSVKELKLAFGEQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M3CYS0</accession>
    <name>M3CYS0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_150941</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF09804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757925.1">
        <property type="nucleotide sequence ID" value="XM_016906488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CYS0"/>
    <dbReference type="STRING" id="692275.M3CYS0"/>
    <dbReference type="GeneID" id="27903625"/>
    <dbReference type="eggNOG" id="ENOG502RHD1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_491046_0_0_1"/>
    <dbReference type="OMA" id="NEMDITH"/>
    <dbReference type="OrthoDB" id="3650057at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF09804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="555" mass="53484" checksum="A60420F511F2647A" modified="2013-05-01" version="1">MAPSPQGLGLSGLTGVLGGLGGGQGAVSSLVAAVPAITSTLPVSVPAIAVPSVVPVAGTPAISGLPNLSIPTGSVLEITKAITVPLASTSLLASLASLPVNSGLPGLEGVLDALSGLPLPTAALPADLPLSLLPTDIIALLPTDLPLSLPLSAPLSLVPTAIQSLLPTGLPADLPISALPIQIPSLPTGLPLVPLAAVSPVQEILANLGTTLITTLAEQLANIISTIVAAAANVPLSGANVTAITPAGRMKMAAPAEEKRQLDGLFGGLLGGLNLGAVTGVTSGLTGGLLANSNPLSSLTGSTLAPLTDGTLLPVGSIVSGLTGQSGGSLLAGLQDSVGSNPLSLLTGLLSGLSLSGGPLGSVTGVLGNLGLGSIILNIVDTLPIPDSLSSIIDGIAQAVVAPVSSILSTGQLTQFSSVLNLLNLFSSLNIGDLGALSSLTNLPGIQTAASGLNTQDLLSVLEILSSLPGGLDLTTLLSDPTSLLTLLETIVPNVQDPVSSAAFVLLGALNLGNLGELTSSLSGAASGSGTAGLTSALGGLTAGLAAGIGASASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M3CZ80</accession>
    <name>M3CZ80_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_26305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757087.1">
        <property type="nucleotide sequence ID" value="XM_016908406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CZ80"/>
    <dbReference type="STRING" id="692275.M3CZ80"/>
    <dbReference type="GeneID" id="27905543"/>
    <dbReference type="HOGENOM" id="CLU_2312969_0_0_1"/>
    <dbReference type="OrthoDB" id="3649243at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF08966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="100" mass="11074" checksum="F85319D2548F54D6" modified="2013-05-01" version="1" fragment="single">VNVDQGPNATKIYVHKSVLCASSEFFKAKARRVWSKGEATVDLPHVSQHAFMLYANWAYSGKVNETSVPDQADWEILAEAAALGQQLMDSAFKHSVMDTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M3CZF1</accession>
    <name>M3CZF1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ZW10 C-terminal helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_22732</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758130.1">
        <property type="nucleotide sequence ID" value="XM_016908360.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CZF1"/>
    <dbReference type="STRING" id="692275.M3CZF1"/>
    <dbReference type="GeneID" id="27905497"/>
    <dbReference type="eggNOG" id="KOG2163">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006571_0_0_1"/>
    <dbReference type="OMA" id="REVQYSQ"/>
    <dbReference type="OrthoDB" id="534815at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990423">
        <property type="term" value="C:RZZ complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046362">
        <property type="entry name" value="Zw10/DSL1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055148">
        <property type="entry name" value="ZW10_C_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12205">
        <property type="entry name" value="CENTROMERE/KINETOCHORE PROTEIN ZW10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12205:SF0">
        <property type="entry name" value="CENTROMERE_KINETOCHORE PROTEIN ZW10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22766">
        <property type="entry name" value="ZW10_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZW10 C-terminal helical" evidence="2">
        <location>
            <begin position="671"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="453"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF10009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="818" mass="90601" checksum="B0D435B4D864A158" modified="2013-05-01" version="1" fragment="single">AVLSYIDHGAYPDDDSIISASLDSDRLAHISTALRKEQDVVKDEIRGLSRSTAGDVDTWIAKAKTLQADILRSRETARQIVAQHEHTKTHIAKVSETGRYVQELEHEVTVYGAIAARLQIIKDLKSLLDLAQDSLVSGDVDTGLAQLQEAEEVVSTKELGDAQSGVGLMLRGRIQRLQENLKTNVQERWNRGVHISIEDHKVVINDGLDQVINAARGLGMFDNLVAKLSKDIERAVFRPRLAHVKNGKVAMIAINEKQLSCQEVSDDISTETLLQDLHRSFGFFAEHLERDIALPLSELLVPRILIHLEDDWLDPAVPVDIQELPDFQTLLHAASSLADQLDSLQWHGSKLLRDWVQAAPKTWLTKRREAVLGDVRNLVFSGLRERKTVERVETQTVSKEDHAALGGSDGGDDWDSAWDDPDESAASPTIVRPAQSVDDEDMSAWDEDGEETSQAPAESQSAAPISTAESQPSQDGDDEDAAWGWDGEDEPQVPNSPKAANPVALSDVKTPSKPAEREITLRETFTVTGIPDAILAHLRQTIADAQALAGPAYASSPLAPASGGLYTLPTQGLALYRATAPTAYAKVDTGNMLVYNDATRLAEQLRAWEAEVPTRSRLKLDHDVKALEQFAKSAYSNEMESQRTILRDLLDGAQGFSSCSEQPAKQECEDAVEQTMLRVRDVHRLWQPVLSTSALLQSIGNLVLSVAQKIIREVEDLPDIGSADSEQLKVLIDKTSQIKDLFLQGDRDMTFVYVPNWFKLQYLREIMVSSLADIKYMWNESELSQEFEAEEVVGLIEALFAESIHRRQAIQEIRRAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M3D116</accession>
    <name>M3D116_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_68513</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759289.1">
        <property type="nucleotide sequence ID" value="XM_016909826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D116"/>
    <dbReference type="STRING" id="692275.M3D116"/>
    <dbReference type="GeneID" id="27906963"/>
    <dbReference type="eggNOG" id="ENOG502QQXH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_4_3_1"/>
    <dbReference type="OMA" id="NVCDDQF"/>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051450">
        <property type="entry name" value="Gfo/Idh/MocA_Oxidoreductases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377">
        <property type="entry name" value="BILIVERDIN REDUCTASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377:SF12">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11840)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="2">
        <location>
            <begin position="27"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF11168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="528" mass="59333" checksum="43CF47DFF8EA116E" modified="2013-05-01" version="1">MNDDRREEQCPTAPAASDNNTSKPRLLIIGAGSRGNAYARATVDSGLGIVAAVAEPVQFKRRLLGSRYIWPSNDPTPEQEFSDWKQYIKYEQQRRKDEAAGVPVPPGVDGVFVCVHDEHHIDVLMAIAPLGLHIMAEKPLATTLADCLRIEKSIRAATNDRIFAIGHVLRYSPHNMLLRHLVREKQVIGDILSIEHTEPVGWWHFSHSYVRGHWRKESTTAPSLLTKSCHDIDFILWMLCSPLSGSKEPAHLPARLSSVGSLKQYRRAQKPKEAGDATNCVSCPISNTCKYSATRIYHEKHLAKGNAKWPVEIANPETEHILETQGPEQAKAALLQTLSEDYDAKTTPVPQIEGRSWYGRCVWESDNDVCDDQYVTIEWDDDDDDQSSNLRAKTASFHMIAQTLSQCERRGRIYGTSGEISYNSKTITLHNFNDDTTHVYHPEVPQNSHHGGGDHGLTQQFLKAIAASNSGEMSVHAAQVEFLGCTMEEIIRSHAAVFAAEEARRERKVVDWREWWQRNVVDVESICT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M3D261</accession>
    <name>M3D261_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_118511</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759333.1">
        <property type="nucleotide sequence ID" value="XM_016901435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D261"/>
    <dbReference type="GeneID" id="27898572"/>
    <dbReference type="eggNOG" id="ENOG502RP5T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1225450_0_0_1"/>
    <dbReference type="OrthoDB" id="3648880at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004033035" evidence="2">
        <location>
            <begin position="17"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF11212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="226" mass="24095" checksum="A3FAD274B94011C3" modified="2013-05-01" version="1">MQIITAILAIAGAAAALPGGGQGDNSYPPSYGNGDPNAYSGPVCVTKSTCNAVYFTTTKQMPYKDTVTVTKTAYKPKVFTTYVPNAYVTTKYLPSAYTVTKHVPVVKTVTIPDHSTKVICKTITIPFNRTSTHATYSASMCPETTQVPKTAIISSYVPKVVTKKSAFAYKTVITNNRYSASVCTESSSTCSYATSCSAQASSSHKNVYPASDPPVYQPPSKPTYKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M3D285</accession>
    <name>M3D285_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Vacuolar protein sorting protein 46</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_150224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759363.1">
        <property type="nucleotide sequence ID" value="XM_016906028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D285"/>
    <dbReference type="STRING" id="692275.M3D285"/>
    <dbReference type="GeneID" id="27903165"/>
    <dbReference type="eggNOG" id="KOG3232">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080826_0_0_1"/>
    <dbReference type="OMA" id="QQITMVM"/>
    <dbReference type="OrthoDB" id="10266568at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904902">
        <property type="term" value="P:ESCRT III complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Snf7"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="161"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF11242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="200" mass="21840" checksum="5469B9F75C693918" modified="2013-05-01" version="1">MSGLEKALFNLKFTAKQLNRQAAKASKDEQTEKAKLKKAISQGHNDIAKIYAGNAIRKKNENLQLLTLASRIDAVSSRVQTAVTMRSVTGSMANVVRGMDQAMKSMDLEKISAVMDKFETQFEDLDVATGYYETATSSATATGTPQEDVDRLMNQVADEAGVELSQEMAGATPAKGIQAPAQHEEEREDKLGERLRALRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M3D2K9</accession>
    <name>M3D2K9_SPHMS</name>
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        <submittedName>
            <fullName evidence="8">SURF6-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_149120</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
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            <taxon>Sphaerulina</taxon>
        </lineage>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
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        <subcellularLocation>
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        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SURF6 family.</text>
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        <property type="protein sequence ID" value="EMF12450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Rrp14/SURF6_C"/>
    </dbReference>
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        <property type="entry name" value="Rrp14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007019">
        <property type="entry name" value="SURF6"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="15"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA-processing protein 14/surfeit locus protein 6 C-terminal" evidence="6">
        <location>
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            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="353"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="519"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="2"/>
            <end position="29"/>
        </location>
    </feature>
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        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
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            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
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            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
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            <end position="234"/>
        </location>
    </feature>
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            <end position="265"/>
        </location>
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        </location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
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            <end position="564"/>
        </location>
    </feature>
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        <location>
            <begin position="567"/>
            <end position="583"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00005904"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF04935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF15459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF12450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="592" mass="65639" checksum="F63C27437DD20FB2" modified="2013-05-01" version="1">MAEEQKDVLDGLEERLQSHSKAFESLLALTPARDYYGAQIEDGLDPDKQWNRKKQTKEEKRAAKKAKLDPANQKTALDVMKEREKKRKRELGMEDAESEAEKEVESQTNSKRQKKDELDPEVRRKQIAEKRKAKRQEKKAKLDAKVLKAKAKREAKLKQQSEEAQAVNSQANGGAEDDELDDNDDDDDNDDSEDDAVEISTADLADVDFSGLAGSDAGDEGHDDIEAIHEHENEEASSAPTSPNVDSPAFDVATNVSEASSSSSIDPPPAVDDTKKPTPKQKSSTNNVKPVAKVNPAHEPKMKAPTQIALPKFDPSTTNAEMPSGTSSPKIQIPNVDQAELQERLRKRIEELRAKRKADGIDGKPATSRQELLDQRRQKEERRKAHKKELRQKAKEEEARKREEQLRGSGSPAADIFSGRNSPRPRSPAENSFAFSRLAFEDGTSADAGLSTLKDAVKKKGPQDPKTALLAAQKKEARLAGLDPAKKADIAEKDMWLNAKKRAHGERIRDDTSLLKKALKRKEKAKGKSESEWTERKEAVVKGKELKQKKRETNLAKRREEKGSKGGGKKKGGKPGGGKKKPRAGFEGRFKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M3D2U3</accession>
    <name>M3D2U3_SPHMS</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_150391</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016906142.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="27903279"/>
    <dbReference type="HOGENOM" id="CLU_1897524_0_0_1"/>
    <dbReference type="OrthoDB" id="10311174at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF11462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="134" mass="14615" checksum="EDA02469A82D361A" modified="2013-05-01" version="1">MCILILRSWPTCGHSNITSTDQCMTAMTTPGMTPHQCHYATIHRFTFSISGPNHNTTTATTATTATTAAAAEDAEDWPCPVCIEENRRLSLDLLRFEHEHEGDSHGHGKRVGRRERMGSKSSSGRSSEGSLGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M3D3U9</accession>
    <name>M3D3U9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DWNN-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_149213</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
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        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="EMF12579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016905417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D3U9"/>
    <dbReference type="STRING" id="692275.M3D3U9"/>
    <dbReference type="GeneID" id="27902554"/>
    <dbReference type="eggNOG" id="KOG0314">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:nucleic acid binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:mRNA processing"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:protein ubiquitination"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="vRING-HC-C4C4_RBBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Zn_knuckle_CX2CX3GHX4C"/>
    </dbReference>
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        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
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        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439:SF0">
        <property type="entry name" value="CELL DIVISION CYCLE AND APOPTOSIS REGULATOR PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08783">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13696">
        <property type="entry name" value="zf-CCHC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01180">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51282">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DWNN" evidence="9">
        <location>
            <begin position="5"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="8">
        <location>
            <begin position="180"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="348"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="535"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="348"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="384"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="567"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51282"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMF12579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="585" mass="63978" checksum="8B9827E0870379FE" modified="2013-05-01" version="1">MSSSIFFKFRNQKDTTPIAFDGSSLSVFEVKREIMRIARLGDGKDFDLEISTSDTNERYDDDTTQIPRSTTVEARRMPASKHGAGRAARYITGSMPLHAKNSHRTESNMRGGAGKNTSAANGVGDMSAMTEEEKLAAVMNASNTQFQADLQSSASMPSKRNTFKSNVAVPDKPLPPGYVCYRCRKKGHWIQACPTNNDPTFDGKKPKRTTGIPRSMLEKVEEPDTDKELPQGVFMNQDGDYVRVKTDDATWQKIQEQRKAAEENAKEADAVDQELVDRGLVCTLDERPFAVPVKTPCCGTTYCNDCIENALIDNDLLCPNCGEQALLDDLKPDEEALDKLAAYDAEKKASRLQKEKEASKSPKVQDVSEGMKSPGSTPNSKKRKADDDLESKRRPSNPAEMKRSRSTQGTPAPGTQLATSQSQPQPPKAPKSMSANTTVTDFAAQMNAMTYSMSGVQNGMNAFTNPMMNPMMGMGMSPMMPVMPNMMGNFNPMMGMGMNGMNGMGMGMGYGNGMGGMGGMNGMNGMGNFGNSNMNGNNQQPWMNGPRVPTGPAADNGGAYIRQPVNPHRHQNRSRRQRSVDYKQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M3D427</accession>
    <name>M3D427_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Histone H3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_44769</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone H3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016908943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D427"/>
    <dbReference type="STRING" id="692275.M3D427"/>
    <dbReference type="GeneID" id="27906080"/>
    <dbReference type="eggNOG" id="KOG1745">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078295_7_0_1"/>
    <dbReference type="OrthoDB" id="842664at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="5">
        <location>
            <begin position="8"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF12654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="99" mass="11461" checksum="74FEEDA16994C55A" modified="2013-05-01" version="1" fragment="single">RTKASIAALREIRKYQKSTELLIRRLLFSRICREITIDLATNASNSVCRFQAKALLCLKEQCESIVTKVFSLANLLAIYYKRVIVIAKDLECLRRLLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M3D587</accession>
    <name>M3D587_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">WAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_148676</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761461.1">
        <property type="nucleotide sequence ID" value="XM_016905074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D587"/>
    <dbReference type="STRING" id="692275.M3D587"/>
    <dbReference type="GeneID" id="27902211"/>
    <dbReference type="eggNOG" id="KOG1245">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002631_1_0_1"/>
    <dbReference type="OMA" id="FVEVHCA"/>
    <dbReference type="OrthoDB" id="332390at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018501">
        <property type="entry name" value="DDT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028941">
        <property type="entry name" value="WHIM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013136">
        <property type="entry name" value="WSTF_Acf1_Cbp146"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32075">
        <property type="entry name" value="ISWI CHROMATIN-REMODELING COMPLEX SUBUNIT YPL216W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32075:SF6">
        <property type="entry name" value="ISWI CHROMATIN-REMODELING COMPLEX SUBUNIT YPL216W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02791">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10537">
        <property type="entry name" value="WAC_Acf1_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WSD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51136">
        <property type="entry name" value="WAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WAC" evidence="6">
        <location>
            <begin position="22"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="DDT" evidence="5">
        <location>
            <begin position="361"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="430"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="622"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="889"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="438"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="668"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="679"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="889"/>
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        <location>
            <begin position="932"/>
            <end position="948"/>
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        <location>
            <begin position="949"/>
            <end position="958"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50827"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF13340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="982" mass="113624" checksum="928BF3ED8DBA9522" modified="2013-05-01" version="1">MVLNKRKPVNLITTPPNVPDSTEVYVMKGTNEVFTDYEKYLKRFDWLNSKKFTDAVNGKSGLTYWDALESETKSSATIETLFPEVLRDPILRNVQFSTITRMDELVNKVFDDFKSDYFPGEDVVCTLDNGEQFEGTIREKAKFPMIRGADGSVQRAPFSRYFIKVHGSPGEEALLDDKHIRRDRKIFTKQNLRAFLKNSLQREPWSGAPWLVKEHLAIQYRLPMEIPQHLFQDAKLLAAKTQVFSMRPPKSKKPKGMPAAEYERLRNQELHQIQQQQMQQHIAGAHPAQLSRYQQQQAHHQMMNQTPPRPPPPPVVRYPIEDLDLAPKRNGATRPELKFFTEELTEYMRGGRKTAVEGIEMRSIGMLLEVWNTLNVQCEVYVLDSFTFDDFVDAMQYHEIDPPCELFEEIHCAVLKLFVDNEGKLLVKDMPRKKVEETQGDDETDMHDDSEVSTPLPDVPARSTRSRLSQMEVVEPDSPTVENRNRAGEMLGDRAWEDRLAARAFTNGGWQVIVVGILHQLSQVPLFKERCDRILAHLAPIDCKPTQETALEQYATMDINLRIAALQLLTVLTIRTDAIKDFLETCMDDMTDVRKRKMEHQREKKIAMEEFAIKDREFKILRPDHLPPSPVHEPTEVTELDPTEGSIDLNGTASSPDPDEDTLAGGRSLRRAGDRKRKREEEQARREKEKAAKAEAAKAHNKAAKEFKKIEKECLELKERIRVQEEKIAECDSDLREANVQRTKVLGKDRFCNRYYWFERNGQPFGGLPSSSTSSYGYANGRIWVQGPDVMEREGFIDRTPEDQREYQRYFQMTVPQRRQQEEGDVQLNTADEWGYIDDPDRLDNLIGWLDDRGERERKLRKELMDWRDHIAQYMEAYKNFLDQEAAKKLDTEEEPTKRVSTRHKHAEEENANKARCLRWSNTMALDEQGHIHSRPPKPKEKKSSKKQAHAEREDRGRGVAVPVNRSGKAMTRQGGDYNSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M3D5Z9</accession>
    <name>M3D5Z9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">SEPMUDRAFT_148645</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761420.1">
        <property type="nucleotide sequence ID" value="XM_016905053.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.M3D5Z9"/>
    <dbReference type="GeneID" id="27902190"/>
    <dbReference type="eggNOG" id="KOG1609">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001266_1_0_1"/>
    <dbReference type="OMA" id="VGTCYMF"/>
    <dbReference type="OrthoDB" id="1108038at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16702">
        <property type="entry name" value="RING_CH-C4HC3_MARCH6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000287">
        <property type="entry name" value="RING finger membrane protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056521">
        <property type="entry name" value="MARCHF6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13145:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCHF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13145">
        <property type="entry name" value="SSM4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23113">
        <property type="entry name" value="MARCHF6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="879"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="919"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1120"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1170"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1213"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1276"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1471"/>
            <end position="1492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1512"/>
            <end position="1530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1566"/>
            <end position="1590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1703"/>
            <end position="1727"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="18">
        <location>
            <begin position="53"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="17">
        <location>
            <begin position="61"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="477"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="653"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="327"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="497"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EMF13299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1815" mass="199963" checksum="DA36E147FB07E01D" modified="2013-05-01" version="1">MTDTTDTSRAERTSDPSRGSAVSFSDIPDLMNDPAFAPPQRRDTASSMKSGTDGDAGGDTCRICRSEGSPDEPLFYPCKCSGSIKFVHQECLMEWLSHSHKKHCELCKTPFRFTKLYDADMPTTLPWTVFIQRAFIHVAMMFSSGLRALVVISVWLLFLPLMIRWAWRWMFWFADAGWARELYIKRMQVADVNAAKAQHSGTELVHDVSAGLQTALYDAYDRWFGSVDWKSTFMQSTTNATATAPSTIRNATATINIYNTTSYWPQADASVLSSWTHLSELTPSPKINRVILDVFEGQLITCVVILGFILVFLIREWVVQQQPLVNLDQLQNERREQERRIQERDRLRRQAELVEEARERLAALQNERVARLRRMQDEDGGASSTNANRAPDIIEIGWDEVYVLIDSATQELSLGGGGREAFMIKASEVMCEILAAESSGADASTLADKVHSKLSELSNEQREAWEEVLLAELEARGARKPGRGASSRESQAAVAESSTAPRRPRMPARAQSSAATVINRVLEEEEVDPDRTARGEAADANPSLDEAAFSASRAENQAVPRGPRPISTTRLLEANPAVKTQVLNEPVPSHNDASATGLETMPITNAGPDAKVNIKRKGTGKARIIVLEPDEEEPAHIIAANELNRLLAKKVASSDAKVPEGTSREEPGANEQEATDLTVYQSRHESESSGPPSDSRVNPFHPDGPMPDSSRSVSNDDIAATSGVNHEETNEEEDQARQAEMGYEAAEATEHDSDVADLAIPTPQRVVPPAGPANWLIDWFWGDIQPQNHSEPIPAAPEERIDPHDPQEAPLVPVQDGAQFIDQEMDDGEPQGAPDPEVLAAAQQVGLDAEAIEDAEDLEGIVELIGLQGPIIGLFQTSCFCSVLVISSVFCAIGVPYMWGKLVLVFINSPVESLIKTPLRFISLFTDFLVDVALLVIGWLATAAIKLVETVTSSVEAFVPWLGDAELTSWCYKISKATAVGAYHRLSSLFPSATDTSADTAGMQWAWLHVSVEAHASLRTIQHESSVVLNYSGSVITSIVECVSSGSATVICHSLLAAVKHIAGNVVRACASLESVKEYVSQWWTTISGMRSGWLLNLSSANSSVAFDPALVYWNSNDRGLAVLAGYVALAMLAAIYVALDTPITSSESHQKTEKVIRDSLRQAGGVLKVILIISIEMLVFPLYCGLLLDIAFLPLQDGASLATRWAYATQAPYTFCFIHWFVGTCYMFHFALFVGMCRKILRKGTLWFIRDPDDPTFHPVRDVLERNVTTQLRKIAFSALVYGALVILCLGGVIWSIGRLFQGIFPIHWVATEPYVEFSVDLLLYTSLTPTLLNLAKPSTIVHAMYAWWLRRCARALRLSHFLFGDRKKDEEGRHVRGTWSSFFLMKTAKLDQATGLILVDNEERPEVFFQRDGKYVLTPCNDQYRPPKPGEAFIHVENNDVYIADKNGKKNDHFARIYTPPNFRLRMTFFMVSLWMFSAFIGLCATLVPLCFGRQVLVMVLPAGVVVNDIYAYSIGAYFFGGLLFLALKGGAGAQYLRQRATEVDFKAWAAAAAKTTLQALKCLYVYGFACVVMPLVFVTTLHFYFLIPLHTHLASSIRPALLDAMNPDAANSTLTAVVNATMQSFSQQGSNFTQASSRSTMPSVAEHSIHVLADGALGMLIGKIVVRGILLAPSSRAAEACRRITADGYLNPNARLATRFIIVPATLLSSVVLLGPLGLANMILSFVTWLGPRMASNFEGITEEVQVLVHRYSYPVTAAWALSLWGTGQMAKATGRWRARIRDEVYLVGERLHNFGEKKPPPGTKGVVRRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>M3D613</accession>
    <name>M3D613_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_148659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761435.1">
        <property type="nucleotide sequence ID" value="XM_016905063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D613"/>
    <dbReference type="GeneID" id="27902200"/>
    <dbReference type="eggNOG" id="ENOG502RHNB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2414692_0_0_1"/>
    <dbReference type="OrthoDB" id="3648147at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF13314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="92" mass="10439" checksum="9FABE2FB8E2A936D" modified="2013-05-01" version="1">MPFSFPTRRTSTQSDSSAKSNSSSRCSSIDETLLATTLPIAPREDNYAISEQIRQKRLLVKCKRLETDGPLCYKSVKQELRQEQEQGSTARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M3D642</accession>
    <name>M3D642_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycosyl transferase CAP10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_148877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761766.1">
        <property type="nucleotide sequence ID" value="XM_016905200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D642"/>
    <dbReference type="GeneID" id="27902337"/>
    <dbReference type="eggNOG" id="KOG2458">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028539_2_1_1"/>
    <dbReference type="OrthoDB" id="202415at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF107">
        <property type="entry name" value="GLYCOSYL TRANSFERASE CAP10 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="1">
        <location>
            <begin position="167"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF13645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="465" mass="53906" checksum="484BA3F96CFA2145" modified="2013-05-01" version="1">MNGIVSWQRLSYILMTLVGIQCFFLYHSIGSSEPTHLPRPARLTEISAEASGYADLESTTQSNATNEYFFNEYVDSLTAEQCEIAFPDIYYEAERATRYWKKRNHIISGDDLHMPPDGHVRFLIHRNELRIINSSNAYSALGRGERALAVTNLLHRAVESAKAGGERLPTIEFTVSLLDITEPPTLHDTYTTWVWTRELADDTTERGKKQRRFWVMPNVEFYASMDRNLGAYHDARHRAAQHDSSLEDKIPEAAWRGTAWVNPELRGGLVNKTKGKPWASVHTIDANDPKHAHQLRMDEFCSYRFAIHTEGIAYSGRLQYLLNCDNLPIIHKLAWTTHWNHLLIPEGPQQNYIPVKRDWSDLESQVKFYTENPFNANMIVKNHLKTFRDRYLTRAATSCYIRRLMHEYASVSWRPEVDESVSRRNDTKTAASKVVRRRGLSFEEVMLNPHDFRNASDFYGNWDYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M3D677</accession>
    <name>M3D677_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_148692</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761490.1">
        <property type="nucleotide sequence ID" value="XM_016905086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D677"/>
    <dbReference type="STRING" id="692275.M3D677"/>
    <dbReference type="GeneID" id="27902223"/>
    <dbReference type="eggNOG" id="KOG0586">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019271_1_0_1"/>
    <dbReference type="OMA" id="IARCEWA"/>
    <dbReference type="OrthoDB" id="410920at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000640">
        <property type="entry name" value="Serine/threonine-protein kinase PRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF42">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SIK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="372"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="206"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="252"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="317"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF13369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="697" mass="76049" checksum="E0B13E1CAFE6B4A9" modified="2013-05-01" version="1">MASLPTRGLDDANANANSSPANQPRQHYYSSSGSSSMSSGNTSSKVAAPGSASTENHNQAAHAANASVLPPLDTTIAPHSSAQHHHHHQRMSSALSLRTNRLETSATAGADAWSDMDTPTIQYEPEAALKLNLTSPSSLPTISSSLRSNMSTTSLASSYSPGSISALPSPYLTAAMTDLTPLPSPLPLPGTEMPLVWPKRQASIASRSREGSLTDGMPSNRSYLPPISPESPSKKKKGYGSLMQEAAVANAAMATGQEQLRTDSHNRNRSLSEFKPEALHNTRPRHVTVGEGEVSGLETGEYHIHREAYLAEQRGLTPAPATSGKPLPTPPPSNASITESDDAEEERPHLEDGTVSEYLEIHCGIHNKRRKFRQLRALGTGTFSTVMLATREKIPAHPTPEIEDHLDPAKLVAVKIVEHGPAGGADEERIETSLKREVEMLKIVSHPSLVHLKACEYQPTRALLVINYCPGGDLFDFANEQRALLTPRLIQRMFAELVSAVRYLHENWIVHRDIKLENVLVNLPPADIEPVENPLTHPAPLVTLTDLGLSRRIPQPPESPLLSTRCGSEDYAAPEILLGQPYDGRLTDGWALGVLLYALLEGRLPFDAPPGKPDRSRNTHRIARCDWIWCRFGDEDGDWDATRGKDLEGANLVVEALLKKVRMGRKSLEDVEKLEWVQRGIQVTGGLQMRPEDEENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M3D7P9</accession>
    <name>M3D7P9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_82263</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762331.1">
        <property type="nucleotide sequence ID" value="XM_016910303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D7P9"/>
    <dbReference type="STRING" id="692275.M3D7P9"/>
    <dbReference type="GeneID" id="27907440"/>
    <dbReference type="eggNOG" id="KOG4210">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027451_1_1_1"/>
    <dbReference type="OMA" id="RVWVNQL"/>
    <dbReference type="OrthoDB" id="1875751at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF95">
        <property type="entry name" value="NUCLEOLAR PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="85"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="194"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="260"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="328"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="384"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="419"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF14210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="436" mass="48280" checksum="A6ABB709ABC6DC4C" modified="2013-05-01" version="1">MTTEKKRKRVEKDDDLAIDISLPEPPSKKAKRKEKKSKSKSVKQAETADGETTASVTAVEDQIHPTRSLQVPVAKGEEAGKRSDHGVWIGNLSFKTTKDSLRRFLLERGGIDETSITRTNLPVDHNTKQNKGFAYVDFTTEAVLNIALTCSEKLLDGRKLLIKDAKSFEGRPAKSKAEEDAAKNGNVSTKAPSKRVFVGNLSFDITRDELSEHFAQAGVVEDVFLATFEDSGKCKGFGWITFADVESAEKAVKGFIFKDQKDGDASDDEEGAQKESKEGSDSEEFTEEQRKRHLKKKKKPMKWFINRIHGRMMKLEFAEDKQTRYTKRYGKGGSKQQQDTLAGGEKQANTGAEEFGEESIEGLARQAAAARDAPKDNKKKRDPKLKGLDKDQRQELRRKKHDARLTAPGAALANAQRSGKATGAAVAGTGKRISFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M3D7Z9</accession>
    <name>M3D7Z9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Winged helix DNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_7757</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF13989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762110.1">
        <property type="nucleotide sequence ID" value="XM_016910165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D7Z9"/>
    <dbReference type="STRING" id="692275.M3D7Z9"/>
    <dbReference type="GeneID" id="27907302"/>
    <dbReference type="eggNOG" id="KOG2294">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077699_7_0_1"/>
    <dbReference type="OMA" id="DWVSQHS"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881">
        <property type="entry name" value="CHECKPOINT SUPPRESSOR 1-LIKE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881:SF5">
        <property type="entry name" value="FORK-HEAD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="7">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="6">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF13989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="73" mass="8533" checksum="028E697B4E7A0623" modified="2013-05-01" version="1" fragment="single">YAQLLHKCLKEAPQHTLSLRELYDWVSQHSQKAKDPNNRGWQNSVRHNLSMNAAFQRVTDRTSASKKGSLWRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>M3D8U7</accession>
    <name>M3D8U7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_148070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762440.1">
        <property type="nucleotide sequence ID" value="XM_016904680.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D8U7"/>
    <dbReference type="GeneID" id="27901817"/>
    <dbReference type="HOGENOM" id="CLU_2814052_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF14319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="67" mass="7682" checksum="98E43419CB978056" modified="2013-05-01" version="1" fragment="single">MKNRLLRATPTYPRMVVPCSSYTKPEELERITSFLVTKFLLSVLDAQPRCPSTRFTIRPTLSLIPSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M3D9U6</accession>
    <name>M3D9U6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Plasmid pRiA4b ORF-3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_162715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762775.1">
        <property type="nucleotide sequence ID" value="XM_016908018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D9U6"/>
    <dbReference type="STRING" id="692275.M3D9U6"/>
    <dbReference type="GeneID" id="27905155"/>
    <dbReference type="eggNOG" id="ENOG502RFZV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_918590_0_0_1"/>
    <dbReference type="OMA" id="SECTFHI"/>
    <dbReference type="OrthoDB" id="245563at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.30">
        <property type="entry name" value="MM3350-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024047">
        <property type="entry name" value="MM3350-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012912">
        <property type="entry name" value="Plasmid_pRiA4b_Orf3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41878">
        <property type="entry name" value="LEXA REPRESSOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41878:SF1">
        <property type="entry name" value="TNPR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07929">
        <property type="entry name" value="PRiA4_ORF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159941">
        <property type="entry name" value="MM3350-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plasmid pRiA4b Orf3-like" evidence="2">
        <location>
            <begin position="17"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF14654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="250" mass="28736" checksum="24AC13AC6505560F" modified="2013-05-01" version="1">MAPTSECTFHIYPKEITNPPVWRTLSVPSDCSFRKLHRALQIAFNWATTHSYEFHVHDPSFDPNAEEAQNSMAEIQRMIMKQALPDSNAPREYLLRVNDDQEWSSTNRQPVDCMHQGMWAHPRTPLKGASKTRLFEVLEKPEYKGKKMTYLYDYGDCWEHDIEVLGTAPVAGKIRCLDGEGHYVAEDAGCFKGWNKVLEAYRTASPDKEQKQNRLWFEKQASNRDPAGLSGDKAKRWDKDAINMKLSVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>M3DAI7</accession>
    <name>M3DAI7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_153830</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF14874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762995.1">
        <property type="nucleotide sequence ID" value="XM_016907531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DAI7"/>
    <dbReference type="STRING" id="692275.M3DAI7"/>
    <dbReference type="GeneID" id="27904668"/>
    <dbReference type="eggNOG" id="ENOG502QVYJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010170_0_0_1"/>
    <dbReference type="OMA" id="IHRKDAN"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF9">
        <property type="entry name" value="TAH-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="12"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="596"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="596"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF14874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="654" mass="71886" checksum="BB72BED3B1250CFF" modified="2013-05-01" version="1">MSMTGRTRCSQACEECKRRKERCDGKFPCMLCVRRGRIEACHYIQSQSQAHNGPRVQKRRRSTTVTTTTTITNIHAAAAVVGGRDHSHDSVSVVSVATRSTPHAAVGRQPVFTGESGTLTFLRAVGSCVEDAVPSHTFAAGCRNQYLVEDMPPIQCSHAMLSISDEDRNELAHFYLSSTTGIFDMFDSGEVLEAVTCWDYSSVEEVTCSMGDATTRLILAIGAQGRGGVGDSELGEQLFLDAQKMAMRHMLEPSTLPFVQVSTLLALYLFFVCRRTVAYTHLGIAIRAAENIGLHQFDVISSLPEKDQLKNLRAWKCLRILDLSSCASLGRTLGTHSSADGDFSMQASFSRIEHGALAAQIDSAGMQLCNIAETILVQVYEVDSLTTQLAYQISQELRAWTHHLPDILVPGTGREIDLDANMPEALCLNALTGAYYWTIQLLTRPFLLAAVRSKQQQQQQQQNTASVQSGPNPDHQPFIDACINSAFRCLDVTIKLTQYQSLPKRLFLANNTTLASALVLGLAFFGDYDQHFPLESGLHKALIFLRHMEVDAQAQHYATIVSDLLDAGKCYVEKRSKEKLESRSVEVEMIFGSVHEKHEGRSSHENHSKEELSSSSLWSVAPDEHRGSSGGAFNTGDCIGAFCGWQFDGDGVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M3DAY5</accession>
    <name>M3DAY5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4604 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_147168</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763361.1">
        <property type="nucleotide sequence ID" value="XM_016904128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DAY5"/>
    <dbReference type="GeneID" id="27901265"/>
    <dbReference type="eggNOG" id="ENOG502SF2G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096170_1_0_1"/>
    <dbReference type="OMA" id="HPIARNK"/>
    <dbReference type="OrthoDB" id="5388322at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027911">
        <property type="entry name" value="DUF4604"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15377">
        <property type="entry name" value="DUF4604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4604" evidence="2">
        <location>
            <begin position="7"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF15240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="167" mass="18285" checksum="FFAA0C3852624A56" modified="2013-05-01" version="1">MSKIKSKDLNYDRSLPPFLQRLHDQKAGHGDIDRHEQPIARAKRAKDPQESEGPTVVDESGETVSTEEYEKLKKAALESTHDTSSIKEANDSAGERRMSGTPLASATIRSDSKVTNGTAQKKRKAVKAIGGQDDAEDEHHVPSGKKVVKKAKKKAQPVKLAFDAEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M3DB35</accession>
    <name>M3DB35_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="6">2.3.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_147042</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + acetyl-CoA = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:17017"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="2.3.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="6">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.12" evidence="6"/>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763180.1">
        <property type="nucleotide sequence ID" value="XM_016904047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DB35"/>
    <dbReference type="STRING" id="692275.M3DB35"/>
    <dbReference type="GeneID" id="27901184"/>
    <dbReference type="eggNOG" id="KOG0557">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016733_10_2_1"/>
    <dbReference type="OMA" id="TMEFESF"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004742">
        <property type="term" value="F:dihydrolipoyllysine-residue acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000010">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000003">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006257">
        <property type="entry name" value="LAT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01349">
        <property type="entry name" value="PDHac_trf_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151:SF90">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 6" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="8">
        <location>
            <begin position="51"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="9">
        <location>
            <begin position="205"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="141"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="145"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF15059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="493" mass="51691" checksum="10A6ABCEE305EA3C" modified="2013-05-01" version="1">MAAASLLARTSRSVATRGAWTQLKTQHAATSRIPALSALARYYASKSYPPHTVISMPALSPTMTAGNIGTWQKKPGDTLSPGDVLVEIETDKAQMDFEFQEEGVLAAILKDSGEKDIAVGNPIAVMIEEGGDISAFEGFSIEDAGGDKSAPESKKEGGQETAEASEAPGNPGSGTAPPAPKEEAPKAVESESTGERLQPSIERSTIGPALAKLALEKGVSLKGIKGTGPGGRITKKDVESAKPSSTSAAPAVAGVAAAPSYEDVEASSMRKTIAKRLTDSMNQNPHYFVASTVSVSKLLKLRAALNTSGEGKYKLSVNDFLVKALAYAARKVPAANSSWREENGKVFIRQHNTVDVSVAVATPVGLMTPIVKNVTGSGLEAVSSQIKDLGKRARDGKLKPEEYQGGTITISNMGMNNAIDRFTAVINPPQATILAVGAVKKVAVPSEDGEGVEWDEQIVLTGSFDHKVVDGAVGGEFMRELKKVIENPLELLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M3DCS0</accession>
    <name>M3DCS0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kinetochore protein Spc24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_131256</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Chromosome</location>
            <location evidence="11">Centromere</location>
            <location evidence="11">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the SPC24 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763725.1">
        <property type="nucleotide sequence ID" value="XM_016902407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DCS0"/>
    <dbReference type="STRING" id="692275.M3DCS0"/>
    <dbReference type="GeneID" id="27899544"/>
    <dbReference type="eggNOG" id="ENOG502S52R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091441_1_0_1"/>
    <dbReference type="OMA" id="AQCTSHF"/>
    <dbReference type="OrthoDB" id="3344830at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11565">
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMF15604.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="194" mass="21791" checksum="6DA6D56BD47D3B6C" modified="2013-05-01" version="1">MVLFDEDPVELMAEATNKFHITPDKDSLTRVHESLHALHQARALRLDNQTSILSSLSRKLNKVNSAHSYDLERHDAGQHAQNMLKMDTEKFRIAKGVSDAEIESERLRGELAALRQQLNTLEREGVEGGRKADGAEDEIVLKLQFYRSLGIDARRDETSGDFNKAVICNAERGDVHVVDIDGGRVDANLFWDAL</sequence>
</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="17"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF16124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="98" mass="11238" checksum="C43B2B7D8608750B" modified="2013-05-01" version="1">MGVFSILPESLQTVELWISRCALMFALLVIGPWLAFILYDILLYIWRTATWRIPYIGGRARGKQRPRAPSLTARPSGHKRQLSFISQNSPRAPSKLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDU6</accession>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
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                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF10335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="307" mass="33960" checksum="B77F323D5D60FCA0" modified="2013-06-26" version="1">MGKFRSTLRKMCCGKNSASVVSHGAESPTTPPVKEEPESSLETSSPPTKEEPKKSLSTSSSSTKPASSPSTPDEPVVQVQKEPEPSFGPPALDQTPIPPPPPTTATTTTTTIITTITTTAKSTTDPFPASPRPFRAPIRSSYTKAYGLAHEQGSKLQLGTPSRTLHPPRAILRAEQKTCSNFFCEIHLAKRSPQQVLWLAKRKMIREMEALVAQMEKGKEKEMWMRKLAALKGVEMYDDDSDFETENDFDDSDSDFDYDSESEGEDEIAAAFDENEGEEEEEEEEEEEQRESMASLADLETLQAIYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1QE27</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_109833</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016900810.1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF10535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="228" mass="25052" checksum="1210D7E83BA1A195" modified="2013-06-26" version="1">MPSSTQSPTNNTTTTTTSPPSTTPSDPSTTTPTSLAKTSPKPFRLLDLPFELVSQILEHSIEGVSSETEPIEIAFSSSSSSSSCVTTTNTTPIIEEGKGEKTTREEKESQSIILGVGNDIIEMKYPPHHHHNTNNTKEEPPHPHPGIFQTCRILRYEALHIHLRKSFFTFPCAGPGIRGIRLDEAAAAEKRGLVDEVYLKMREELLVGRNGMLSKVSCAVDLKKDVIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1QEY4</accession>
    <name>N1QEY4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-like 1-activating enzyme E1A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_156696</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759864.1">
        <property type="nucleotide sequence ID" value="XM_016907689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QEY4"/>
    <dbReference type="STRING" id="692275.N1QEY4"/>
    <dbReference type="GeneID" id="27904826"/>
    <dbReference type="eggNOG" id="KOG2014">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002556_4_1_1"/>
    <dbReference type="OMA" id="EFFGQFD"/>
    <dbReference type="OrthoDB" id="1708823at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000011">
        <property type="entry name" value="UBQ/SUMO-activ_enz_E1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF162">
        <property type="entry name" value="SUMO-ACTIVATING ENZYME SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01849">
        <property type="entry name" value="UBIQUITINACT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="8">
        <location>
            <begin position="45"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="421"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="426"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="452"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF11743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="472" mass="50948" checksum="C583A29ACD459235" modified="2013-06-26" version="1">MANSDTTMSNGPNPSNGNSTDVAATNGASESTVAPGLSADEMALYDRQIRLWGAKAQEQIRKAKVLLVSLRAVGTEIAKNLTLAGIQELTIIDNEEVTEDDIFGAQFFLRKEDVGKPRAEAAAPRIQELNPRVAVKSGGNLQDLLMKATTDPTYWTQFNCVIACDHDIMTLSSINIAARVALRPFYAAGIHGFYGYIFADLIAHEFVVEREKPNRETAIAPETLTRSVVSVTTRKENNGKTTEIVKKAEMYCPLLLANTAPLPVEITSNRRKLKTVPPLLPCLRALFDFQRESNRLPDVNKEDITRFTELVKQKTAELALPLDTLNGEFLKSFIQNIGAEINPTAAFVGGRLSEDVINVLGNREQPIQNFALFDGESVEGRILSLFSAPPELQPPGLAVYNAPLGNDVPLSNGALGTTHFGGNGTMDLSGSQQQNGLDSAPRLPDADPATANVRTIGNDNAESGPSGTAPSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>N1QF32</accession>
    <name>N1QF32_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_120523</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757808.1">
        <property type="nucleotide sequence ID" value="XM_016901613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QF32"/>
    <dbReference type="GeneID" id="27898750"/>
    <dbReference type="HOGENOM" id="CLU_1982961_0_0_1"/>
    <dbReference type="OrthoDB" id="3942519at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF09687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="126" mass="14165" checksum="7C5BEA1FC428E27D" modified="2013-06-26" version="1">MANFSPSFAVPVQQFSDPAIPSSMANILILIDILIDIKIKTIIRRVHQQQYLQCQNNAHIRNEDEVLENLLKDPGYWPDDGEKVVKSLDVDLSRLFGEGEELGVGMDMEDLLNGECYDEDAEVKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1QF51</accession>
    <name>N1QF51_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_67176</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759969.1">
        <property type="nucleotide sequence ID" value="XM_016909779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QF51"/>
    <dbReference type="GeneID" id="27906916"/>
    <dbReference type="eggNOG" id="ENOG502TM8H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139874_0_0_1"/>
    <dbReference type="OrthoDB" id="3625848at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF11848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="144" mass="16853" checksum="B22F5AB5F53011D0" modified="2013-06-26" version="1">MATYLTRPASNSEGITAELERLSIIGIQRINNRDWSYSSPEAQELLTPEQWQSRFDNQVELLTWQQQNDVWQQLVEELHPHCHFEITSVSSTIREKENLAIVWIQTTVTGIENVHIPGLSELSWRLEDGKWWFFYHVGIRGFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFA2</accession>
    <name>N1QFA2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="4">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_149715</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="4"/>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759978.1">
        <property type="nucleotide sequence ID" value="XM_016905726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QFA2"/>
    <dbReference type="STRING" id="692275.N1QFA2"/>
    <dbReference type="GeneID" id="27902863"/>
    <dbReference type="eggNOG" id="KOG1863">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003532_2_1_1"/>
    <dbReference type="OMA" id="HTAHHRF"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004175">
        <property type="term" value="F:endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031647">
        <property type="term" value="P:regulation of protein stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02659">
        <property type="entry name" value="peptidase_C19C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.210.10:FF:000011">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000005">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024729">
        <property type="entry name" value="USP7_ICP0-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029346">
        <property type="entry name" value="USP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF644">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14533">
        <property type="entry name" value="USP7_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12436">
        <property type="entry name" value="USP7_ICP0_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="MATH" evidence="11">
        <location>
            <begin position="75"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="12">
        <location>
            <begin position="235"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="520"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="533"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF11857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1178" mass="135099" checksum="17C7962844C66B04" modified="2013-06-26" version="1">MDLGSDMLLDGSDYDEKQLTPTDDDNVAIISPDDADSMIDDADPASQPVAPRADDHEAMMARWMPPLPDQETEAEAVSTWDITDWVKQPKRTHSPTFYCAGHPWRVLFFPAGNSAADSVSFYLEQGHLGDAAQKPRDGWYACAQFMLVLSNPNDPSIYLHHEAHHRFTAEEGDWGFTRFADKNRIFAPKFEGHDRPLVEGGNARMTAYVRVVKDPTGVLWHNFINYDSKKETGMVGLRNQGATCYLNSLLQSLYLTGAFRKAVYQIPTETPEEKEASNSAYMLQRLFYSLQADQVAVSTNELTRSFGWESRQIFEQQDVQELSRILMEKLEARMKGTEAENALEQMFVGKMKTYLRCINVEYESSRIEDFWDLQLNVSGCKGLHDSFKDYVQVETLEGDNKYAAEGFGLQDAKKGVIFESFPNVLHLQLKRFEYDFQRDAMMKVNDRYEFPEIFDASPYLDETADKSEPYVYHLHGVLVHSGDLNAGHYYAFLKPEKNGQFYRFDDDRVTRATKREAIDDNFGGDYQGANGVQKGQNPYTRQWSTKRSNNAYMLVYIRESRLDQIILSDEQAKPPEHLPAKLKEERLLADRRRKEKEEAHLYMNVLVATQTNFRLHDGQDLIPWTDESTNPAAPTIYRLLRSMTIAQFNKHVAEQQGLDPDLIRPWIMVNRQNGTVRPDHPLLWGEMTLQEAADKFSTRSSGFRLYMEETERDPDGKPIWKLDDEAYAAPLSTGVQNQTNKPIILFLKHFDVDKQELRGVGHVYMMPSDKAQDLAPHILQMMGWQVGELSLQLYEEIKQNYIEPMKPKNTLVAAEIQDGDIICFQRALSGPEQDAMRQTNPTACLDAPSFYDFLVNRLFVNFSPKSAENLHVRTEEELTFQLALSKKDSYDALAHKVADYLSSKSDTPIDHSHIRFTSTNPQNGKPRTAVKRQANSTVSQILSGPNGYGSYGYQPSQTSDHLFYEVLEMSLADLEQRRIVRVTWLTEGIQKEEMHDILVHKQGDFAEVLTALQQRANLPAEMMNQIRFYEAHGNKVYKILPLSHSVVTLNEFMSLYAERIPEEQVQVDETSGDRLLYCFHFEKEPAKAHGVPFIFLVKHGEMFKDTKERLSKRTGFKGKNLEKIKFAVIKGGQVYSRPVWIEDDDCLAEKLGPEDHLGLEHPNRNRSNWGRYESLNIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFN4</accession>
    <name>N1QFN4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_149833</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760168.1">
        <property type="nucleotide sequence ID" value="XM_016905798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QFN4"/>
    <dbReference type="STRING" id="692275.N1QFN4"/>
    <dbReference type="GeneID" id="27902935"/>
    <dbReference type="eggNOG" id="KOG0061">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_57_7_1"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03213">
        <property type="entry name" value="ABCG_EPDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052215">
        <property type="entry name" value="Plant_ABCG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48042">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48042:SF11">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="443"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="487"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="525"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="554"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="650"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="81"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF12047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="674" mass="75156" checksum="FA8AEA2EAE320FB4" modified="2013-06-26" version="1">MSRGKQVNTVKKYPSHCHTPDRPRSMQSRTSFRSDIEMLIVPDEMRASHSTHGTVEQVHMEDIEKHASPRSSFANEDVDCLAWKDLTVTVKDRATGLDRDILDNASGIVRPGEMVALMGPSGSGKTTLLHTLAQRQTAAVHGQVLINGEEHPLATHRAISSFVEQEDTLTGSLTVEETLVFAARLSLPRTVTRREARERAGKLIQSFGLTGQRRTLIGTPLQKGISGGQKRRVSVATQLITGPRVLYLDEPTSGLDSTASYEVISFIRDIARRTKLIVIASIHQPSTKTFDLFSSVVLLSQGKTVYNGSVPEMSTFFAEIGMPIPAHINPAEEVLDLINVDFSQGDAQTNLEIILRGWQQSARARELKRDVEGGSARRLRLEITDGKPSFAAQTATLLHRALIKSWRDLVAYWVRVAMYMGLAIMMGTVWLRLGTTQENIQPFINSIFFGSAFMSFMAVAYVPAFLEDRAIFVKERANGLYGPTAFLLSNFIIGLPYLFLIAVLFSIVSYWLIGLRPEAGAFFTWIMWLFLDLLAAESLVVFMASLFPNFVVSLALIAFANGLWMSVGGFLVSLPVLNAFWKYVFHYIDYQSYVFQGMMVNEFKERSYACETIAGQCSCMYPSALQDQCRIAGTAVLSRYGYALNREGQWVGIMIAIIAVYRLLGWAVTWFRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1QG06</accession>
    <name>N1QG06_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BAR-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_149964</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760379.1">
        <property type="nucleotide sequence ID" value="XM_016905881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QG06"/>
    <dbReference type="STRING" id="692275.N1QG06"/>
    <dbReference type="GeneID" id="27903018"/>
    <dbReference type="eggNOG" id="KOG3771">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072096_0_0_1"/>
    <dbReference type="OMA" id="TRFCAYF"/>
    <dbReference type="OrthoDB" id="446293at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990528">
        <property type="term" value="C:Rvs161p-Rvs167p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07591">
        <property type="entry name" value="BAR_Rvs161p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000014">
        <property type="entry name" value="Protein hob3, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037429">
        <property type="entry name" value="Rvs161/Hob3_BAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF3">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01251">
        <property type="entry name" value="AMPHIPHYSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAR" evidence="4">
        <location>
            <begin position="17"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF12258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="261" mass="29747" checksum="63E93FCE1225A434" modified="2013-06-26" version="1">MSWNGLKKSVGRTTTNLMMKTGHVERTTDREYEVEERRYRTLEAASLRLQKEAKGYLDSLRAMTASQMRIAETIDAFYGDSGASDGVSRSYKQAVEDLDAETIKALDGPYRTTVLEPINRFCAYFPDINECIKKRNHKMLDYDAMRSKVKKLVEKPDKDASKLPRTEKETEMAKAAYEQLNQQLSDELPQLIDLRVPYLDPSFEALVKIQLRFCAEAYSRMAQVQQYLDASTRDQYAGGDLDARVEDVLGQIRELSIAGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1QG10</accession>
    <name>N1QG10_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">26S proteasome regulatory subunit RPN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_151482</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the proteasome subunit S2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757604.1">
        <property type="nucleotide sequence ID" value="XM_016906845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QG10"/>
    <dbReference type="STRING" id="692275.N1QG10"/>
    <dbReference type="GeneID" id="27903982"/>
    <dbReference type="eggNOG" id="KOG2005">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008705_1_0_1"/>
    <dbReference type="OMA" id="GTCNGDI"/>
    <dbReference type="OrthoDB" id="10252509at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905754">
        <property type="term" value="C:ascospore-type prospore nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000026">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016643">
        <property type="entry name" value="26S_Psome_Rpn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002015">
        <property type="entry name" value="Proteasome/cyclosome_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041433">
        <property type="entry name" value="RPN1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040892">
        <property type="entry name" value="RPN1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01851">
        <property type="entry name" value="PC_rep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18051">
        <property type="entry name" value="RPN1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17781">
        <property type="entry name" value="RPN1_RPN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015965">
        <property type="entry name" value="26S_Psome_Rpn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 9" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="RPN1 N-terminal" evidence="7">
        <location>
            <begin position="66"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit RPN1 C-terminal" evidence="8">
        <location>
            <begin position="870"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="636"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="647"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00057191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR015965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF09483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="926" mass="102401" checksum="B4627472D46C30C1" modified="2013-06-26" version="1">MAKEAEKPKAVDNKGKGKAEDGKQAKSVKGAAAKDGKDGKDVKKDGDLDLPPEELSEEDQKLKDELDMLVERLTEADSSLYEAALEAIKTSIKTSTSSMTAVPKPLKFLRPHYDKLAEAYEKWPKGANKDSLADTLSVLGMTYSDDEGRRDTLKYRLLAPGTDIGSWGHEYMRHLALEIGQEYEIRQQEEKDSEDITSLALVLVPFFLKHNAEADAVDILSELEMIEHIKEHLDENTYSRVCLYMASMVPLLTYPDNDRFLRTAHDVYLQYKQYTQAISLAIKLNDLELIKSDFNSAPDKPTKCQLAFLLARQRISIELDDDDANDEELQECLNNTKLPVYYKSLAKELNVLDPKVPEDIYKSHLESNRTAGLTNTDSARHNLASTFVNAFVNAGFGQDKLMLVEGGVKQSWVWKVKEEGMLSAAASAGMLLLWDVELGLDKIDAYTYVPEDKIKAGAALAMGVMNAGVKVEGDPTLALLGDFEGKTVSDKVARILGLGLAYAGSNNESVLDVLLPLVRDTGLDMQLSATAALSLGLVFVGTAHSDVSEAIIETFLDEDRNKQLKDKWTRFMTLGLAVLYFGQQEEVDVILETLKAIDHPMSKPASVLIEMCAWAGTGAVLKLQQLLHICNEHIEEKEDKDDDDKEEEKKDGEDEKKDIAGEQLVQAYAVLGLALVAMGEDIGQEMVLRQFGHLMHYGEPNIRKAVPLAMGLISVSNPQMKIYDTLSRYSHDNDVDVAVNAIFAMGMVGAGTNNARLAQLLRQLASYYHRDPGALFMVRIAQGLLHMGKGTLTISPFHTDRTVLSRVSAAGLLTVAISLIENPKAFILGDHHYLLYHLAIAMNPRFLITLDEELKPIQVNVRVGQAVDVVGQAGRPKTITGWQTQSTPVLLGHGERAELEDEEWLSVANTMEGICIVKKNPDWESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1QG61</accession>
    <name>N1QG61_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_151516</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>UDP-alpha-D-glucose + 2 NAD(+) + H2O = UDP-alpha-D-glucuronate + 2 NADH + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="3"/>
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        <property type="protein sequence ID" value="EMF09538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_016906866.1"/>
    </dbReference>
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    <dbReference type="eggNOG" id="KOG2666">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023810_7_0_1"/>
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        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:NAD binding"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006024">
        <property type="term" value="P:glycosaminoglycan biosynthetic process"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0006065">
        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
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    </dbReference>
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        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR028356">
        <property type="entry name" value="UDPglc_DH_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11374:SF3">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11374">
        <property type="entry name" value="UDP-GLUCOSE DEHYDROGENASE/UDP-MANNAC DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
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    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500133">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
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    </dbReference>
    <dbReference type="SMART" id="SM00984">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="UDP-glucose/GDP-mannose dehydrogenase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDP-glucose/GDP-mannose dehydrogenase C-terminal" evidence="10">
        <location>
            <begin position="351"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="460"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="464"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="494"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="23"/>
            <end position="28"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
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        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="108"/>
            <end position="112"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="149"/>
            <end position="150"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
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            <end position="298"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
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        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
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            <dbReference type="EMBL" id="EMF09538.1"/>
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    </evidence>
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    <sequence length="559" mass="60390" checksum="F6BCE88173DD0B45" modified="2013-06-26" version="1">MTPPMSATQQGKRKTVKKICCIGAGYVGGPTSAVIAKQNPDITVTVVDLSEARIGAWKSNALPIYEPGLFEVVEVARDCTDGRRLPNLHFSTDVAGVIHEADLIFIAVNTPTKTEGLGAGGASDLAYVESAARHIAEVATSDKIIVEKSTVPCGTADNIQEILDAHAAPNVHFDILSNPEFLAEGTAMNDLLKPDRVLIGSHKDDRSLIAATALADVYAAWVPRDRIITINLWSSELAKLAANCMLAQRISSINSLSAICEATGANIEELAFAVGQDTRIGPKMLKASAGFGGSCFKKDVLSLAYIAETLHLPEVSAYWKSVVDINEYQKERFAKRITKRLYNTLRLKKIAILGFAYKKNTGDTRESAAITIVGQLIAEGAQIAIYDPQVSEATIQQDLIREHRADVVKQRVTVYPDAISACENASAVVILTEWDEFKTDQVKPLPDAPGTRREVVVPQVHGPSDASSSLSSASSTSEAESDFMDSALGTPAPVEREKSEYVESVDPADKRVDWVQIASSMKRPRLVFDGRNVVSSEKLASLGFTVECIGKPGLRQRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1QG95</accession>
    <name>N1QG95_SPHMS</name>
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        <recommendedName>
            <fullName evidence="1">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="2" type="ORF">SEPMUDRAFT_150008</name>
    </gene>
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        <lineage>
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            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
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        <property type="entry name" value="YIM1/Zinc_Alcohol_DH_Fams"/>
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        <property type="entry name" value="ALCOHOL DEHYDROGENASE RELATED"/>
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    </dbReference>
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        <property type="entry name" value="ENOYL REDUCTASE (ER) DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF12317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="358" mass="39137" checksum="092BB4E572E6091A" modified="2013-06-26" version="1">MSIPKTARAWTYTNGYPNTLTQSTISLPSPDEIQNDENSFLVRIAACALNPVDIQTQNLPNWNIPLTPLNYNHPKGTVMDFSGTVVAAGAKSQFTAGDEIFGMTLKPYAPPAGGALAEYAKFDAATTPAVRKPKEWSFEQAAAISLVWLTAKECIEKVESWVEKTKTKTVAVLGGSSSVGIYTIILAKKRGWKVVATSSGRNKGFVLDELKADAHVDYTSQNVRQGVDAFQPDVVIDCVGGTECIGLPSSKRYISIVGDKTGRTMMGGPYTYYDILHPFTAAMQWLRWARGEYGLGESYDVVILSPKKEWLEDAKETLTADDIHIDSVHAFEDAKQAFERLNTGRAKGKVVIRTGSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGB1</accession>
    <name>N1QGB1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_45971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760458.1">
        <property type="nucleotide sequence ID" value="XM_016908981.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.N1QGB1"/>
    <dbReference type="GeneID" id="27906118"/>
    <dbReference type="eggNOG" id="ENOG502QVDP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001347_0_0_1"/>
    <dbReference type="OMA" id="KMWTITA"/>
    <dbReference type="OrthoDB" id="3548913at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42064">
        <property type="entry name" value="YALI0F28677P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42064:SF1">
        <property type="entry name" value="YALI0F28677P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1003"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1304"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1003"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1026"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1304"/>
            <end position="1318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF12337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1441" mass="158516" checksum="90D05A838DD62768" modified="2013-06-26" version="1">MHRPQHPRDSLARPPADAATAAITAAAAAATATTATTTATTTATAAAAAPPTHHNDLPDAVCLSQITHLLRLQKYHKRCCASAQDHLQKLHIAAAKAARLRLTARSVQHTLAECIRSEDKSSFAVLLHAFQDAREDASKIPSPAVQDVDSRGPPAAASSSSSPSTSPSSTHHPATSFLDELAAPARLTVLDVLTKLRYDGHFIAERVLSLTSRELNALLPERIMTKSSESIFAAPSRNSRSSRPLGFTVDTVVDVLTGHSYGSPLEALVYAPSACLLTDDSERRRTTDVWATVCARLISEQKSGSEKLIPALLDIWSTLLPWPGKDRIEIWMLDTLQRGAFLLLDQPTKQTFRARVESRSGVSLRDEAQVEAFYAGATESLLELFGDRTAPSAIPPGALSLCHAIYDKLRTSTPYQRALPSFILTRWLFSSFTSHLVNLPEAYTLMTDHYMSDVSRQRILREIAVRAQKAVFDVAYDWKHGNVLVPETVQRVNAIMTRLTGPAAAAAAAAASPVDCSTGTILPSTPFLVVSLKDVTTILAALYPHRRPSSISSDSDAFKSGLQSSASSVSGFSLFSNASKSPDQWANDLPGSSPYHRELFHGCGGEGMVPDSSREDGMHDGHILDAYRDLEDISTRTSSTTELWGVVAVESEHKSLCTMRQRYSHLRHIRRCHSSPNSPRERMDEAHLAVAQSLEAVLRRYGPPPSWQHLGQDSTAPPSAWCQLQRLFGSAIHDCQARSDFVSAQRWFQQMQDAHAAILPPQGTAALARILRVLQADARLSVDEVAALESLSLQWSAALQPRSALHLASLKTISKENEALRDKMWYISDVRTSAVYEEVRLVASALRIMGKSARAVPKQRSPPPLRHWNSTRVSHASLHLKSEAQILELLSARLDHGGPNKLSDEQSKATMQWMQRENIDNLCKGEERLHRLYLEVRKCVDVVSSSSHVENAMLWSNVLFAADHSFRTTRDVGPRKAAFLPGLYGSSLQSDYLSLSSQLRSNDSLSTTSHTLSNSSSRDYLDARSPTLTNRSSAPFWSPAMSEVDSPSSATSVISSHTQSALDMTPLKDVTNRLSADSRALERLRQRVTSLILSDLTSTLFSDGSETDQAFWTGLGLELAERHLRSVHSWQSSAGSHTPTVTTDMPARPSFMMRFDFDHAFERLMQKFTAHSNPTTKLACLYDIDRLVVPYMAEQQQQQRWASPSTSSMRTARDANRLTLNTTGTDDATGVSIAGFRSLFARSSLRPRTIFRDLQCIASLLPASVLCDTPQGKAFTHAALALTSLKAEVREIMVETADSIIAYHSNNRGHGRSPSTAQQERDSAIFPAPSPPAADISRYSMADAAHLLQITAKEGDIVAQRELATLYLTHPELLDRVIAPFARPKDVFKDEMEGKWKKNQDPHRMDPATMCVAHHWMSLSSKGGDLLAKEYLRQREEMDSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGG3</accession>
    <name>N1QGG3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="6">PPIase</shortName>
            <ecNumber evidence="6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_103696</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cyclophilin-type PPIase family. PPIL1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764417.1">
        <property type="nucleotide sequence ID" value="XM_016900511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGG3"/>
    <dbReference type="STRING" id="692275.N1QGG3"/>
    <dbReference type="GeneID" id="27897648"/>
    <dbReference type="eggNOG" id="KOG0881">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_16_3_1"/>
    <dbReference type="OMA" id="ELYNDHA"/>
    <dbReference type="OrthoDB" id="256333at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000008">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF4">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE DOMAIN AND WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF16296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="172" mass="18804" checksum="7A3704E7B659BADA" modified="2013-06-26" version="1">MATQVVLETSLGPITIELYTEHAPQTCKNFRELCSRKYYDGTIFHRIIPDFMVYGLNNTTSQIQGGDPTGTGRGGSSIWGEKFDDEIRSDLKHTGAGILSMANSGPNTNGSQFFVTLAPTPWLDGKHTIFGRVKSGLNTVKKLGLVKTSAEDRPEEEVRIVSARVLQGEDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>N1QHR8</accession>
    <name>N1QHR8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ubiquitin-conjugating enzyme E2-21 kDa 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_76239</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764861.1">
        <property type="nucleotide sequence ID" value="XM_016910131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QHR8"/>
    <dbReference type="STRING" id="692275.N1QHR8"/>
    <dbReference type="GeneID" id="27907268"/>
    <dbReference type="eggNOG" id="KOG0416">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030988_7_1_1"/>
    <dbReference type="OMA" id="KFYVRFK"/>
    <dbReference type="OrthoDB" id="269518at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010637">
        <property type="term" value="P:negative regulation of mitochondrial fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd23797">
        <property type="entry name" value="UBCc_UBE2H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000061">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="6">
        <location>
            <begin position="3"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="150"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="172"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF16740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="187" mass="21214" checksum="D92F2634CD3FE998" modified="2013-06-26" version="1">MSSPKRRIETDVMKMLMSDYEVTLVNDNSEQEFYVRFKGPEETPFVGGHWKIHVELPDQYPYKSPSIGFVNRIFHPNIDELSGSVCLDVINQTWSPMYDMVNIFEVFLPQLLRYPNPTDPLNGEAAALLMRDSKGYDAKVKEYVTKYASKESVDDAGNDSNDSDEMSSVGSFDDDDDDEPAGTMDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1QIB4</accession>
    <name>N1QIB4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_127503</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the sal C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759039.1">
        <property type="nucleotide sequence ID" value="XM_016902148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QIB4"/>
    <dbReference type="STRING" id="692275.N1QIB4"/>
    <dbReference type="GeneID" id="27899285"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036835_0_0_1"/>
    <dbReference type="OMA" id="TNPWVSA"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000793">
        <property type="entry name" value="C2H2 finger domain protein FlbC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001102">
        <property type="entry name" value="Transcription factor IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051565">
        <property type="entry name" value="Sal_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23233:SF84">
        <property type="entry name" value="FI23031P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23233">
        <property type="entry name" value="SAL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="250"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="278"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="207"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF10918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="317" mass="34042" checksum="D554381F09ABB881" modified="2013-06-26" version="1">MAMAVDSRQQHPFSNMGYDNARYPQPPHFTNPWGSSPASTQGPMYATPMPQTTVGADSRYVHAPTASPAYAGGLPAQDMSAPRPYGASYTSGPSPQSTYAPTAAPSYATAYGYDRRSSHPLNQASEAERQSFSDALDASRGMVAMSQSDITPRNIYGATNPARSAATDSYGFPAGHSSHSSISSGSTYPTYYNSSVSEASVDYSSASESADLSHSRTLPPPHALQGMPPAPQSMMGQFSSKVSSSSQKKHKCKICDKRFTRPSSLQTHMYSHTGEKPFACDVEGCGRHFSVVSNLRRHRKVHKGEGGDVHSHDEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1QIY7</accession>
    <name>N1QIY7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_57286</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765271.1">
        <property type="nucleotide sequence ID" value="XM_016909428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QIY7"/>
    <dbReference type="GeneID" id="27906565"/>
    <dbReference type="eggNOG" id="KOG0013">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054816_1_0_1"/>
    <dbReference type="OMA" id="GCMGRYL"/>
    <dbReference type="OrthoDB" id="1640476at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.225.20">
        <property type="entry name" value="Ub domain-containing protein, DC-UbP/UBTD2, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032752">
        <property type="entry name" value="DC-UbP/UBTD2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038169">
        <property type="entry name" value="DC-UbP/UBTD2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039869">
        <property type="entry name" value="UBTD1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13609">
        <property type="entry name" value="UBIQUITIN DOMAIN CONTAINING 1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16455">
        <property type="entry name" value="UBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="217"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF17150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="291" mass="32016" checksum="72A57EBE8606D77C" modified="2013-06-26" version="1">MGCCQSRAGAVRGESPFANNTSANVAGTPDHSLPNNYLGSVPTQPAGSASSRRGDGTVTRPNQPIQPPEPVRHSPKNFSYHQPPWTRAILEQQRKEFFDTRTNNSREVWNALALVAESMRHGDLAQAQAIMDAANITCPHGRVARGRGKNRQLEGVYDSRGKLYEIPYWLVTDPADIIEQGDDEKDTDDTRDDATSLQGATREKGKGRADGDIGNEVRVTARLNNTARDVTVDIGTKQTISVLRRKIEEQSHVRLKRLIHLGKILNDDQTLEATGWKPGQILSAFVDEGTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJ19</accession>
    <name>N1QJ19_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DUF1772-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_104466</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the anthrone oxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765291.1">
        <property type="nucleotide sequence ID" value="XM_016900542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJ19"/>
    <dbReference type="STRING" id="692275.N1QJ19"/>
    <dbReference type="GeneID" id="27897679"/>
    <dbReference type="eggNOG" id="ENOG502SBMN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105974_0_0_1"/>
    <dbReference type="OMA" id="PFTWVFM"/>
    <dbReference type="OrthoDB" id="5954308at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013901">
        <property type="entry name" value="Anthrone_oxy"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35042">
        <property type="entry name" value="ANTHRONE OXYGENASE ENCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35042:SF3">
        <property type="entry name" value="ANTHRONE OXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08592">
        <property type="entry name" value="Anthrone_oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="129"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF17170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="183" mass="20203" checksum="0108AE652434AD26" modified="2013-06-26" version="1">MLDSLAADPKTTLAVSVMAGSFLSGTMMSLSLMAVPVFLDTTDHAPQLFSEWVAMYNYGFPTLPTISIATCGLYLYTALRARALDSPWALYAAVAGVTTVVMVPFTWVFMWPTNETIMALEKQSRGGRRGGEEEKKGKKVENQAGEIREARRLVKKWSRIHFTRSLFPLTGALVGLYGLLKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1QK49</accession>
    <name>N1QK49_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ecp2 effector protein-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_146583</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765727.1">
        <property type="nucleotide sequence ID" value="XM_016903747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QK49"/>
    <dbReference type="STRING" id="692275.N1QK49"/>
    <dbReference type="GeneID" id="27900884"/>
    <dbReference type="eggNOG" id="ENOG502RM8Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1482881_0_0_1"/>
    <dbReference type="OMA" id="CAFNVRV"/>
    <dbReference type="OrthoDB" id="3648775at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029226">
        <property type="entry name" value="Ecp2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14856">
        <property type="entry name" value="Hce2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110934" description="Ecp2 effector protein-like domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Ecp2 effector protein-like" evidence="2">
        <location>
            <begin position="48"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF17606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="182" mass="19059" checksum="21FDB5F6BF7E378B" modified="2013-06-26" version="1">MQLNNALLITLLPALSEAVGFLQKSDPSMASLAQVDDHAGNASGANNCGLTSWDDYGKSTPSSQLPLVADCQKIIDQEAVLDFSNPITHGKSDPQILYAHGTCAFAAALGDGAPSGLTAYVGNADVKDLVGDSIKNYSHDRWVGTQGGYTMLVGTDGGVQCDSNGPGHVQIPVVWWVQRSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1QK75</accession>
    <name>N1QK75_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyltransferase family 8 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_49447</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759095.1">
        <property type="nucleotide sequence ID" value="XM_016909113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QK75"/>
    <dbReference type="STRING" id="692275.N1QK75"/>
    <dbReference type="GeneID" id="27906250"/>
    <dbReference type="eggNOG" id="KOG1950">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049943_1_0_1"/>
    <dbReference type="OMA" id="HVCVCNL"/>
    <dbReference type="OrthoDB" id="2014201at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF10974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="372" mass="41900" checksum="F7831BFAD951840C" modified="2013-06-26" version="1">MPGPNPNATADSNPLSRAWLTLVTRASYLPGLAVLVDSLYKHGSKHPLIVQYTTDLPEDCIKCLQLLHGLYPLCLPQRVESIPLPDGLEPVAARFADTLTKLRAFQPLTQNELDVLGLPSTPKEICFLDADILIMRNLDDIFDVPRPGSDWVASHHACVCNVDGDPLAPPEYSIENCPFTRVEHPEALEQPVLVPETEAQKKTYALLNSGVFVCTPSQELWQKIQDFFTNNEALVKTFKFPDQNFMEVFFQDKWVPLGWQYNAIKTHRYWHSAAWRDDEVRALHYIIDKPWEVRTGKGDAAGYLGRDGVTHSWWWAAYDQFVEEMARRGDVGRAVVACVSRTLNPADSAQRRVGGRELLARLGRKSALPVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKL0</accession>
    <name>N1QKL0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_34581</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapA family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764938.1">
        <property type="nucleotide sequence ID" value="XM_016908577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QKL0"/>
    <dbReference type="STRING" id="692275.N1QKL0"/>
    <dbReference type="GeneID" id="27905714"/>
    <dbReference type="eggNOG" id="ENOG502SG3E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049343_0_2_1"/>
    <dbReference type="OMA" id="YNFPVVC"/>
    <dbReference type="OrthoDB" id="191315at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF47">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="2">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF16817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="316" mass="34166" checksum="EFC842BA358296F3" modified="2013-06-26" version="1">MATTTTPKVPPAGIWAPAVTFFDPETDELDLEAQKKYYTYLSQHLTGLVILGTNAETFLLTRSERASLLQTARSAVGPNYPLMAGVSGHSTKQVLEFISDAAAAKADYALVLPCAYFGKQTTGAVVKKFYQEVAEKSVLPVVIYNFPGVCNGVDVDSDVMVELKGRCENIVGTKLTCAQVGKITRLSSAFPASTFATFGGQSDFLIGGLASGSAGCIAAFANVFPRTISHIYRLWKQGNTDEALRLHQIAAGAESVTKAGIANTKYAVSLTSARWAGIEGAEEKLRPRRPYEEPEEKVKGEIRKRIEEMIKIEESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKR1</accession>
    <name>N1QKR1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_145522</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764324.1">
        <property type="nucleotide sequence ID" value="XM_016903105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QKR1"/>
    <dbReference type="GeneID" id="27900242"/>
    <dbReference type="eggNOG" id="ENOG502QQGC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010748_0_1_1"/>
    <dbReference type="OMA" id="TRCVKRN"/>
    <dbReference type="OrthoDB" id="65716at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000002">
        <property type="entry name" value="Zn cluster transcription factor Rds2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056751">
        <property type="entry name" value="PAS_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053045">
        <property type="entry name" value="Zinc_cluster_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31986">
        <property type="entry name" value="REGULATOR OF DRUG SENSITIVITY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31986:SF7">
        <property type="entry name" value="REGULATOR OF DRUG SENSITIVITY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24990">
        <property type="entry name" value="PAS_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="74"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="282"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="294"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="315"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF16203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="571" mass="62980" checksum="BED6A7318748D91B" modified="2013-06-26" version="1">MAEPQTTTDPLLTIASASSAAAATQDPKDSPSTQSQGQSSPKRKAEDAGSSVVPDSTTNSSGDGKKKRRKVNHACVYCRRSHMTCDLERPCARCVKRDIGHLCHDEPREPPKRSKSELVVAELAPAPGDGLNGHTAAHLHGNGAGSGIGNGNGNGMSLVNGVSQQAQLAQTTTISPANIQRSTPQTADSTAGFLQNVDWNNNGVQSQFQDMHHLHPNYMFNHPEVTNEYNLLNDFLSSSIMEDGAMYTDSNTEALFEDPLLATSAMVAHVNDPDLASLNSTVQSATTSNAGPQQRPPSQPMQPPSLPTPQVAPGQDTTRPSSTYQIDSRARDKFYMTAADPAGLSSAEDRLQKLLKAKYDAGMLKPFNYVRGYARLNQYMSKHVTRASQLRILKQLDRFRPKFREAMQSLTDMQLVLVEMWFERSLMEYDRVFASMAIPACCWRRTGEIFRGNAEMAELVRVPVSHLRDGKMAMHEIVKEDSLVSYWEKFGAIAFDQSQKAILTSCTLMRPAKRKDDSDGDDAGKEQKEKMEAVRCCFSFTIRRDTHNIPSLIVGNFLPITERRQPNGQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKR4</accession>
    <name>N1QKR4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_33946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764329.1">
        <property type="nucleotide sequence ID" value="XM_016908553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QKR4"/>
    <dbReference type="GeneID" id="27905690"/>
    <dbReference type="eggNOG" id="ENOG502RZT9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042059_1_1_1"/>
    <dbReference type="OMA" id="YLLTTFY"/>
    <dbReference type="OrthoDB" id="1887033at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF16208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="328" mass="35567" checksum="59AD1762A000B740" modified="2013-06-26" version="1">MDALEESSHPASRRAADRLPSFIKFPALVLVSLSLSAFIHTLASNYTGPELGSVSRELTEEWQIGVMVGWKLSELAAAWYLRYDYIDLAWLTLLSNVPHYFLLHTFFGIDPLAALVPLAIDVVTIAIPFAIFRGTIHARDTTAPRTPNQLVAQDTGILVIIAALGAALYTITIYTSFYTWLPTYMVIHFDGLKSLEKAHNAVGPILAILFLPLGYGAAHLIFVPAIGSPANPGRTDPSLEKAVFDPANATFGQTLAYNLGCSPAGFTPRAEILFKRTAILATSTFVNSLVRSYVTIEGTEFMGAVGWSSIWAVASLLTGLAFSWVGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>N1QL05</accession>
    <name>N1QL05_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">E3 ubiquitin protein ligase</fullName>
            <ecNumber evidence="15">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">SEPMUDRAFT_149702</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the BRE1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="15"/>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759962.1">
        <property type="nucleotide sequence ID" value="XM_016905718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QL05"/>
    <dbReference type="STRING" id="692275.N1QL05"/>
    <dbReference type="GeneID" id="27902855"/>
    <dbReference type="eggNOG" id="KOG0978">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019713_2_0_1"/>
    <dbReference type="OMA" id="YRQMQEY"/>
    <dbReference type="OrthoDB" id="654191at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033503">
        <property type="term" value="C:HULC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16499">
        <property type="entry name" value="RING-HC_Bre1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058643">
        <property type="entry name" value="BRE1-like_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013956">
        <property type="entry name" value="E3_ubiquit_lig_Bre1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23163:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE BRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23163">
        <property type="entry name" value="RING FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08647">
        <property type="entry name" value="BRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26095">
        <property type="entry name" value="CC_Bre1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="11 15 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 15" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="684"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="242"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="190"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="287"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="562"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="639"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU365038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EMF11841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="738" mass="83088" checksum="6695A51C81C835CD" modified="2013-06-26" version="1">MTATKTVLPALPSLSKTAMEDRKRSLMNDVEDLAPSRKRLKDENGATMRMDEDKEKQVEDYQKDAIIRQLKEYKRQKRDADEQLVELQRKVTYHDDHIRVVDAWWSQLLDEIRIRVGDELPTPPPSATSAIIGEEIYNRALHFDDVESFSAHLKARSANLKNAIKDLFAKVPSASSPSEEQLQRRLGELLAREKEHAVELKKAIDEKESMYERLEAAMGRYMTAERKLDRAKSSQVQKLERQAIMGSNGDGTSPTTSKAAALPKREHGDSNGELENGVDTAEAEALRKEAIAIADKQKAQVEEIEVENERLTNELSAARTKLASLTDDDYMETSHYKILKSMYEDVVKRVNDLEAFNKQLREETQKLQAERAATRTQVEEETRNHISEVEAANARAETDLARIRHARDQLNSELAVLKASDDIPKSSLALAQEVAEAKDSRISALESKVQRLELQLGEAEAAELDLDGLDVDALRAKVQTLTNQYSLLANELPSLEAAWRKLQATANKKIEDIAHWEDQLSRLAAEKAKADHKYFGAMKAKDTQEAQLRTAKSQNSRSSEIVTQLKDEAAKAKDLCSNYERQLAESKEAYTKLEQQHRTAEQKLKEATFASDGLKKSSEELKTLVAARDKEVLGTSKAKRQAEEDLEKCKARLDDTKKQYDALRKSRAAVNAADSDDWRKVAICPVCSANIRNTVLKTCGHVFCHNCVKDLISNRNRKCPSCARSFGTNDHQTIHLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>N1QM91</accession>
    <name>N1QM91_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_145712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764595.1">
        <property type="nucleotide sequence ID" value="XM_016903221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QM91"/>
    <dbReference type="STRING" id="692275.N1QM91"/>
    <dbReference type="GeneID" id="27900358"/>
    <dbReference type="eggNOG" id="ENOG502SATJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056572_0_0_1"/>
    <dbReference type="OMA" id="FGAKHSE"/>
    <dbReference type="OrthoDB" id="4158841at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17242">
        <property type="entry name" value="DUF5315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="284"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF16474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="317" mass="34401" checksum="F97C50B2350BD230" modified="2013-06-26" version="1">MATTTQSGALSSQKPSPTANTKPNRLPAPTLFIAPPSRNASNLSLSRQQPAEATLNLERDPISRHKSGLPRSRNAIDNAQQQQPISEDDSENSPHTQKSSVKKASERSLETRWKEMQNTLNEVELTAQSSTHVFGESHARALEDLRKAQVELARAWGRGNQDEKDTDPTKAQSIEKNMSDRFKGADSLAKDRVVAERNRGDTDASVSTMASTALSDESAQSGPDVTSKSGRSQLEDETKQDIKLASERRAANEAYFRKVDGGVREVVQKLEIVAQAMRGVEAQSRSLWSDSSSDLATSSEEAGNKKDVKVEGGAANG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>N1QN33</accession>
    <name>N1QN33_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fungal_trans-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_153702</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765983.1">
        <property type="nucleotide sequence ID" value="XM_016907522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QN33"/>
    <dbReference type="STRING" id="692275.N1QN33"/>
    <dbReference type="GeneID" id="27904659"/>
    <dbReference type="eggNOG" id="ENOG502S5RK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008828_1_0_1"/>
    <dbReference type="OMA" id="DEIGIMY"/>
    <dbReference type="OrthoDB" id="3971593at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="58"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="14"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="159"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="207"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="686"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF17862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="809" mass="88810" checksum="4ACA06AF80F52432" modified="2013-06-26" version="1">MSLNSALDVQSIASLAQQQQQDEQNAAHDSVNANGTKRKAEDQGGQPRARRNRYVSIACNECKRRKIKCNGQNPCQRCGNLNLDCVYAPNCCAGFKDSAEFKDMSGQISMLQEHVNALYDQFNQLRSQIGGQLATVGPQSNTSIDPSLQQYPPDRATFTNAQTSPGVPLSPAHFHRPRASSQSQNRYKGPTSVAFNLGVAKTSLESMGIAGPGEEDVSGNGEADTGTAEGSPHRSPTWKVPRGQALQQMHADKDPIWSIPQEEAIRLCRVYEDEMGLMYPVLNIGKVVDYATKLYRFMEAAHRSGLMQQGMPGSDAIDDEETNILKLVIATALTTEAGGRSELGQRLFEYVQPAIDAMLLGAVGVPAIRMLTMTAMYEFQRDNEGTSWRIIGLTARLCIELGLHRRETYDAIQDEDDRTETMLLFWSIYVLDRRWSFGTGMPFALQDSDIGPQMPKPEDRSPYLSAMIQYSAIASKVWRSVAASASSEKGSMPIKNDEMDYLDYQVIQWHRNIPQHLRFEHPSSPGTTRVPIPVGPSPSRGAHRLRIILYLRANQMRILIYRPVLHSATSIIQHREQAQTAVDVAKDTIRVLTHINQTSDLYRTQQVLFNAFLTSALAVLFLAVSHTPAVFAEDVREEFYMALDLVRGFSKGSWVSKRLWKTIRVLKEVGPKLGLQMKESSAVATAVTEPAQIPKKPSASGSNIQDDPDPNRSAAVAMAGLAGVNVDEMNLYNGGVPQQHQWNATNHGASSSPENMVHDLSSLFEAAGGFHGLAGVNGTDSVGGFAADHTGVGDGFGDEGLSNILQELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNH5</accession>
    <name>N1QNH5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferroxidase</fullName>
            <ecNumber evidence="3">1.16.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SEPMUDRAFT_146720</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.16.3.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the frataxin family.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.1" evidence="3"/>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765884.1">
        <property type="nucleotide sequence ID" value="XM_016903819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNH5"/>
    <dbReference type="STRING" id="692275.N1QNH5"/>
    <dbReference type="GeneID" id="27900956"/>
    <dbReference type="eggNOG" id="KOG3413">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080880_0_0_1"/>
    <dbReference type="OMA" id="YSEHYFN"/>
    <dbReference type="OrthoDB" id="1897642at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034986">
        <property type="term" value="F:iron chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.920.10:FF:000004">
        <property type="entry name" value="Mitochondrial chaperone Frataxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.10">
        <property type="entry name" value="Frataxin/CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017789">
        <property type="entry name" value="Frataxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002908">
        <property type="entry name" value="Frataxin/CyaY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036524">
        <property type="entry name" value="Frataxin/CyaY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020895">
        <property type="entry name" value="Frataxin_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03421">
        <property type="entry name" value="FeS_CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03422">
        <property type="entry name" value="mito_frataxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821">
        <property type="entry name" value="FRATAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821:SF2">
        <property type="entry name" value="FRATAXIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01491">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01219">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55387">
        <property type="entry name" value="Frataxin/Nqo15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01344">
        <property type="entry name" value="FRATAXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50810">
        <property type="entry name" value="FRATAXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0409">Iron storage</keyword>
    <keyword evidence="6" id="KW-0410">Iron transport</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMF17763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="217" mass="24155" checksum="4657E710BE32A13C" modified="2013-06-26" version="1">MSAPATTRLMRQWLRRGSQASITPTITRQLHPQAAAATIRRVVPQIVLSQPRWLSISHAARAGIMPESEDPKPPNDEVMAPGNQQPAQLSEDEYQELSDVQMDLICEKAEAMQESREDVEVEYSAGVLNIVFPPNGTYVINKQPPNKQIWLSSPISGPKRYDWVVSGESMHQKEGGGQGEWVYLRDGTRLNALLSKELGLAIDHIEEDMTPSKDATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNK5</accession>
    <name>N1QNK5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_146768</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765959.1">
        <property type="nucleotide sequence ID" value="XM_016903853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNK5"/>
    <dbReference type="STRING" id="692275.N1QNK5"/>
    <dbReference type="GeneID" id="27900990"/>
    <dbReference type="eggNOG" id="KOG0534">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003827_7_1_1"/>
    <dbReference type="OMA" id="WIDFFIP"/>
    <dbReference type="OrthoDB" id="436496at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00322">
        <property type="entry name" value="FNR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052128">
        <property type="entry name" value="Oxidoreductase_NAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46505">
        <property type="entry name" value="OXIDOREDUCTASE NAD-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46505:SF1">
        <property type="entry name" value="OXIDOREDUCTASE NAD-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="4">
        <location>
            <begin position="67"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="120"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF17838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="356" mass="39666" checksum="5948BE170EED8DB8" modified="2013-06-26" version="1">MLTRLGHYYRHYWPKAPSSLLSSPWKWKTSPGGISILPSRRRSMATINSSSSSIPHEQRTQAEPREPQIEPVVLSHIRQINDEIRLLRLSAVDPTHTIRFLPGQWVDTFLPTVRQAGGFTITSTPNEARPTSTRSSSSSSSSHSPPYLELAVQKSKNPPAQWLWRPMEDILGTQLAVRVGGSFTWPPPPGLLDTSAIERLVLVAGGVGINPLISIFTTLVRMPAQLRPPEMHFVYSTKTDPDLDVQKILFMPRLMDAIAMAADPNVTLAAFLTGLGNEGIIEHGKLPNRTYGRRFQEEDLVKALDGYKTSGFGPEHDRKNTVAYVCGPPKMTDEVVANLRSQPGMSDDRVLCEKWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>M3ARN5</accession>
    <name>M3ARN5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_152431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF08159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756280.1">
        <property type="nucleotide sequence ID" value="XM_016907441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3ARN5"/>
    <dbReference type="GeneID" id="27904578"/>
    <dbReference type="HOGENOM" id="CLU_1272963_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF08159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="217" mass="24636" checksum="D15914601F158CF5" modified="2013-05-01" version="1">MMRYHHCLRSSRLHVAAPCCSPASSWRGDWCPAARADVSCSSFHLRGSRYVQPAAVSTTSDFSAKLVHGDTTLLRCNGVAQKWFMGRTMNLQEQAHYCSTTVWVAGPGFSLLSHRKSWSRTRDQAKKKFLSTHLLQKRILMQEHRSCQTLAVNRPIDTGVIQYKVRTTPADYIPHFVRRATRKPLAHVQTCCAYSTSNGFLARCTSTRSTKRTCWRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M3ASQ4</accession>
    <name>M3ASQ4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-rRNA processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_128861</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756655.1">
        <property type="nucleotide sequence ID" value="XM_016902238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3ASQ4"/>
    <dbReference type="GeneID" id="27899375"/>
    <dbReference type="eggNOG" id="ENOG502QZVV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006918_0_0_1"/>
    <dbReference type="OMA" id="HYNITKL"/>
    <dbReference type="OrthoDB" id="5596576at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059065">
        <property type="entry name" value="Ig_Tag1-like_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059066">
        <property type="entry name" value="Ig_Tag1-like_5th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046368">
        <property type="entry name" value="Tag1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055011">
        <property type="entry name" value="Tag1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35895">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35895:SF3">
        <property type="entry name" value="PRE-RRNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26174">
        <property type="entry name" value="LEA-2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26150">
        <property type="entry name" value="LEA-2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26153">
        <property type="entry name" value="LEA-2L_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22786">
        <property type="entry name" value="Tag1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Tag1 C-terminal" evidence="3">
        <location>
            <begin position="447"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="Tag1-like fourth Ig-like" evidence="4">
        <location>
            <begin position="588"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="domain" description="Tag1-like fifth Ig-like" evidence="5">
        <location>
            <begin position="746"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="558"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="720"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="725"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF26150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF26153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF08534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="884" mass="95130" checksum="FA8FAD6FE8E894D4" modified="2013-05-01" version="1">MADGRRAEDGQRDVEASESTPLLGAGQAEHADQSRPQDETSATSLLRDIQSSGRKKRRWPSIVALLALCVVAALIIIFAFVAPAAVEQYAAEAIVFEPTSLSIDSFTSTGVRARVQGNFKLDSTRVSTASVRRLGKLCTYIAEEVETGRGTMAVSLPEYGNVLLGTAQIPPIKAYIRDQHITGIDFLTDLAPGDIEGIRRIANDWIDGRLGSLRVVGRAQVPLKSGLIHLGQQIVQQEMTFDNDDIPAIPAYDIKKLNFREVDIPGGKGMAADVSVKVQNGFPVDFTIPPLSFGVLVDNCEKSDPYIMLAQAITERIHIQPKMAVVANATGTVHQLPAVLTQDCPGTSKSPLDIFLGRYIHGETNTVYVRGSDSPDLDTPGWITDLMRDITVPVPIPGRSFGHLIKNFSLTDTHFSLPNPWAEPNTPAANPRISAKVRALVALPEEMNFSIDVNKVRADADVFYKGKKLGLLDLSKWQAANSTRIEAGKEDGPMLMVESAVEDAPLEIQDEDVFTDVIQALMFGSKTVVMSIKAEVDVGVDTALGDFAIRKIPAEGSVPIKPISRPQPPSHGDHPPKHDGKGLIGGLHPRITDLNIVNTTTTSLTILAGANITNPTNYSATIPYIDIHIMKNGSLLGHATARDLSITTGLNAGLKVEAIYAPLDFGGPAAKVIGRELISQYISGWNTTITLQMHEKSIPANPKLGRALSHFPIEVLAPQLGAHSPPKDKNHHGAPDNGDSKRKVSSGPHFIKDATMHLLSSSATFLLLSPLQHSTLIITDLNATAFYNEDPAGHPHDIGDPVGDIIYTLPLAVPPISETPGEEGFLTPKLPVDWSLGSVGYGAVKRALGGTLKLSAKADVGVQLGRWRERVWYQGGGLGVRIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M3ATE6</accession>
    <name>M3ATE6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-lysine N-methyltransferase EFM5</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Elongation factor methyltransferase 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">EFM5</name>
        <name evidence="6" type="ORF">SEPMUDRAFT_151722</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that trimethylates elongation factor 1-alpha at 'Lys-79'.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756910.1">
        <property type="nucleotide sequence ID" value="XM_016907000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3ATE6"/>
    <dbReference type="STRING" id="692275.M3ATE6"/>
    <dbReference type="GeneID" id="27904137"/>
    <dbReference type="eggNOG" id="KOG3350">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074410_1_0_1"/>
    <dbReference type="OMA" id="CNFRPEH"/>
    <dbReference type="OrthoDB" id="206354at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03187">
        <property type="entry name" value="Methyltr_EFM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019369">
        <property type="entry name" value="Efm5/EEF1AKMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041370">
        <property type="entry name" value="Mlase_EEF1AKMT1/ZCCHC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13200">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13200:SF0">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10237">
        <property type="entry name" value="N6-adenineMlase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF08789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="243" mass="27782" checksum="5693FBF36355FD89" modified="2013-05-01" version="1">MDDDDILELPADTLQLLAQFHADRDAKAKEFENLKTKAESAFENGSGKLSMDLFGEDWNASQFWYTDHTAEVLARQLLEDATESSAIAVVSAPSVYVALRNILAEQVTATRPKLCLLEFDRRFEVVGSDFEFYDFQNPLRLPASLKGQFDRIICDPPFLSEDCQTKTALTARFLAKTWSPSSEQVLRFISCTGERMESNILRLYQTIGVKTTTFEPEHSKGLSNEFRCYSNFECDVWKWRDIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M3B0G7</accession>
    <name>M3B0G7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_132616</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761403.1">
        <property type="nucleotide sequence ID" value="XM_016902503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B0G7"/>
    <dbReference type="STRING" id="692275.M3B0G7"/>
    <dbReference type="GeneID" id="27899640"/>
    <dbReference type="HOGENOM" id="CLU_531223_0_0_1"/>
    <dbReference type="OMA" id="IESSACR"/>
    <dbReference type="OrthoDB" id="3637989at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="18"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF13282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="456" mass="52363" checksum="DF86294F62FBDF74" modified="2013-05-01" version="1">MATTQRMHSDNQRSHHLAPTFTSLPTEITTLIVQALPRDDHNASAINLALTSRRNQDIAEKVIWRKLFVRTGQQCEKVWNCLRARPLRFQAVHEVELRAQFSHELGLEKFVRILDRAPNVQHLTIESSACRYTRWLVDGNWPRIGRDINSLLKRSAPVLIQSVAAASTDPPLQKLKRLKIHSNGDSHAGLASMLARPRALETLYLGESRAHYQIGDMGGDLLATDKAQTSAALEQQGHSLQRLVYRPLDPQLLGDHDDNVFTLAGLALNGFNRVFENLWQLRDFFIDSELRSQSPLERAALTAAPQLRKLTVTHYADAEPGSENGFEDLRRKWRIYQLAHRCTISNTLERLEVRVVSRYRMAYFRNQAMDLIIEIAVEILSRNDIEFRLFFQRTDEVQTPPFLYDEVEPRNYLIFDSEAGGWQPWVGLDVDEAELVVESGEEEEEEEEEEDDEDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M3B499</accession>
    <name>M3B499_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">LicD/FKTN/FKRP nucleotidyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_63162</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762738.1">
        <property type="nucleotide sequence ID" value="XM_016909625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B499"/>
    <dbReference type="STRING" id="692275.M3B499"/>
    <dbReference type="GeneID" id="27906762"/>
    <dbReference type="eggNOG" id="ENOG502QREF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052528_2_0_1"/>
    <dbReference type="OMA" id="FQGHHFN"/>
    <dbReference type="OrthoDB" id="444255at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009100">
        <property type="term" value="P:glycoprotein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009644">
        <property type="entry name" value="FKTN/MNN4/W02B3.4-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007074">
        <property type="entry name" value="LicD/FKTN/FKRP_NTP_transf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15407">
        <property type="entry name" value="FUKUTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15407:SF32">
        <property type="entry name" value="PROTEIN (MNN4), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G03790)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04991">
        <property type="entry name" value="LicD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004031792" description="LicD/FKTN/FKRP nucleotidyltransferase domain-containing protein" evidence="6">
        <location>
            <begin position="21"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="LicD/FKTN/FKRP nucleotidyltransferase" evidence="7">
        <location>
            <begin position="96"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="LicD/FKTN/FKRP nucleotidyltransferase" evidence="7">
        <location>
            <begin position="221"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF14617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="302" mass="34941" checksum="0308A11DCD385D47" modified="2013-05-01" version="1">MHLPFQLILCSLLSLQISTASPFIAKRDADFASVRTRLDRPRVKQDSKHPNKYFHESSFHMHYDGRFADQQLKYDAKHLHLTALIQAYLSTMSDIGIETWLMHGTLLGWYWNRLVLPWDSDIDVMVSENSMRFLAAYHNMTMYRWKGTAYQEIHHYLLEINPHCKESGYDKENKIDARWIDTNTGIFIDITTLRRNRTAATASDSDNDSNNDSESDDSKDMMMVKDGHSYTFDDIFPLRDTVFENTSALVPYAYADILAKEYGNQALSDVYYEKHYFDVKQSAWVPQKLAILSNGGDSNTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M3B6X1</accession>
    <name>M3B6X1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cycloheximide resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_37912</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763688.1">
        <property type="nucleotide sequence ID" value="XM_016908686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B6X1"/>
    <dbReference type="STRING" id="692275.M3B6X1"/>
    <dbReference type="GeneID" id="27905823"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_13_0_1"/>
    <dbReference type="OMA" id="LVQCTIG"/>
    <dbReference type="OrthoDB" id="2585655at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF20">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="337"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="453"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="487"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="513"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="66"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF15567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="557" mass="61016" checksum="5C3933747FDFBFC0" modified="2013-05-01" version="1">MAFGILEDYHMEVVPGTALLRDQSNNLPDQLTAVPAERLKHGTGRFAHVVLVPQPSDSPNDPLNWPTWKKDLILFIVGINAGIVGAYGPMLGPGFVPIAAELGITVETLSHATAWLILTLGLCVFLFNPLAKIYGKRPIYVATSAILFVVSIWGAVADTYPSFLGSRILGGMGMAPYEVLVQATISDLYFVHERATRLAVWNLFLLCGICGAGFISGYIIEDLGYKWTFGVCAILFGVFGMGILLLVPETAYIRPTVTAEILAARANGDDEKADEKSHGLHIEFQEEITCSALTGNGTSPDAAIESKMSYVKSLRLLSGRYTNAALWKIFARPFLMFFYPSVLFAFLVFGLTLTWIVVFSVVNGVLFTAPPYNFSVSQAGLTSLSPFILCIIGEVVSGPLNDWLCLRLAKANNGIYEPEYRLVLMVVVVLTGTVGFYGFGVTVHYETHWTGPVLTYGLANMSLAFATTCCFGYVLDCYPKLAEEAFVAINARNLVTFGLTYFVNTWLAEDGALAVFNVLGSCFLAVCALTVPLWIFGKRIRSWTARNEWLNQFMNDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M3B707</accession>
    <name>M3B707_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PR-1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_123861</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763733.1">
        <property type="nucleotide sequence ID" value="XM_016901866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B707"/>
    <dbReference type="STRING" id="692275.M3B707"/>
    <dbReference type="GeneID" id="27899003"/>
    <dbReference type="eggNOG" id="KOG3017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035730_5_1_1"/>
    <dbReference type="OMA" id="WANEYAF"/>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05380">
        <property type="entry name" value="CAP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004031785" evidence="2">
        <location>
            <begin position="25"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="3">
        <location>
            <begin position="100"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF15612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="269" mass="28656" checksum="168D85A4631B4738" modified="2013-05-01" version="1">MHLIYPFAALVATALALPAQLVEHNEVQAVAGVALLLTPEGAQEIHEKRQTRMRHTSTARSSTTSVRPTSTTTASRTTSTSTRSSSTSSGASPTGTLPLTLAQRAVLHHNLHRRNHSAPDVTWDTTLAGYAQTLAERCSFQHNTSIGGSAYGQNIAAGLKDNNITSVITDLWYGSEFNAYLPSYYGQEPDMSKFGSFGHFTQVVWSTTTTIGCFVADCSKTGLANVGSNVPPYLTVCNYGPPGNYIGNFGKSVGKPLGQAIAKWNTGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M3BTU0</accession>
    <name>M3BTU0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Meiotically up-regulated gene 190 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SEPMUDRAFT_71128</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758186.1">
        <property type="nucleotide sequence ID" value="XM_016909930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BTU0"/>
    <dbReference type="STRING" id="692275.M3BTU0"/>
    <dbReference type="GeneID" id="27907067"/>
    <dbReference type="eggNOG" id="KOG1012">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002125_3_0_1"/>
    <dbReference type="OMA" id="WAKFGKV"/>
    <dbReference type="OrthoDB" id="419768at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04041">
        <property type="entry name" value="C2A_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04052">
        <property type="entry name" value="C2B_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21676">
        <property type="entry name" value="SMP_Mug190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057349">
        <property type="entry name" value="C2_Mug190_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037767">
        <property type="entry name" value="C2A_Mug190-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037765">
        <property type="entry name" value="C2B_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47348:SF2">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED 190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47348">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25331">
        <property type="entry name" value="C2_Mug190_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25669">
        <property type="entry name" value="SMP_MUG190-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="266"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="14">
        <location>
            <begin position="324"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="583"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="804"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="161"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="396"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1143"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="55"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="183"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1152"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1185"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1206"/>
            <end position="1217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMF10065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1279" mass="143539" checksum="5565C13FC7EF5F33" modified="2013-05-01" version="1">MSGQEDAERSRKNFHGAYGQNRPIPTISRYEKEKEARQAQALPDESDEASGPALDESRTERAKNTWRDYWSRDDGAEQKASQNDDGKSDAGRDGEITDQQDDESEEDTEVAADTSEVSPADPKTRRKNLKKGREDPAERRVTDPVTHLPVRIHDFTKQSLEEVEENPAPWGSTSRTATGLSNKRKDAGQLEQETKDAQDGLDSMNALFPPPSFDSLRDELIGVNRLGITVGLLGAAVIVLLAVALEHIFTPDRLAYWTNANVEARWWIFKSGTWLILGTFSGAAIWELIACTRIWVTNRIEDVWQEQVWEANLEARERAAKAHDTESVSWLNSLFAAVWPLVNPDLFVSLADTLEDVMQASLPRVVQMVSVEDIGQGSEALRILGVRWLPSGAAAKSVGEDGKLGKEDQETHKNDRTVPGEGEVDQGAEHHDNDDKDDESGSGDGTERAAVAEGMEAEEGDFINLEVAFAYRARASKSFHDRTKDIHLYLAFYLPGGLKFPVWVDMKGLVGTCRLRLQLTPDPPFFSLCTLTFLGQPKVDISCIPLVKRGLNIMDLPLISNFVQSSVDAAMAEYVAPKSLTLDLKDMLAGDDFKKDTNARGIIVVDIMHGYDFKMGDAAVPLLSKGGSDPYISVAWAKLGKPLFSTRVLVKEMDPYFHERCYLLVTPAELNVDERLRLQLWDSDRFTADDDLGRIEVDLKQLMRSDDTNGKMHYRKDGFKALKRGETMPGKLEWQVGYFSKTRLQECQYKKQTFDEDIRSKDDLDRKVDEICHNKLREAMVKKGRHARSRQELEQQKAQEKKTFEDAIIISAPPPDDYCSGIFSLVVHQITGLELEVQNKTVADKHAAHENEDEENSGLPSAYCSVIINHQKIFKTRTKPKNAKPFYNAGTERFIGDWRRAEVYVTVRDARPDENDALIGIVHLPLGEIFKTRSQVNGFYPLTGGVGYGRVRISMVWRSVQLQARPEQMGWDYGTIEISPSISTADVPGDLSELKVKWHSNISSGKMYPHKEDSTWQTRKGRSLFLAVHSRYATCLSLRLKRNGRLLAKDKTAAFAVLWLRDIPDDCEKEITLPIYTGNYERATSCVLEKPGEQIGSITVKMTFWSGLGAGHQRWASKDADVRQVMEVLDTARDNYEAKRNAEDRGIVVAGDDGSSSSSSSDSDSDSESFSDDASRDPKAVMDPTTTQHSNGTSTTTTTTSDMTDGDTREDGRQHMNLIDKVKDYKNEAKEKHRTHRGIMQYKPARNLQHVKEKLDRVESKVEGMFSRHTREPGIETEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M3BU52</accession>
    <name>M3BU52_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">DUF221-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_151203</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758326.1">
        <property type="nucleotide sequence ID" value="XM_016906670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BU52"/>
    <dbReference type="STRING" id="692275.M3BU52"/>
    <dbReference type="GeneID" id="27903807"/>
    <dbReference type="eggNOG" id="KOG1134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002458_0_0_1"/>
    <dbReference type="OMA" id="CSCKKEN"/>
    <dbReference type="OrthoDB" id="1689567at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF5">
        <property type="entry name" value="RE44586P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="452"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="506"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="546"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="597"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="644"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="671"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="709"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="736"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="10">
        <location>
            <begin position="36"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="11">
        <location>
            <begin position="238"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="450"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="856"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="868"/>
            <end position="877"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF10205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="885" mass="100209" checksum="0D3673FAC5D8832A" modified="2013-05-01" version="1">MDDSYPYFTQGKDGGDHDHDPWGDLVGATNPRDTTIQIVLSLLLGIGAFLAFCFLRPRWKDLYAARKRTKNAAVSLPELPDTTFGWIMPLWRITDQQVLASAGLDAYVFLTFFKMAMKFLLVTLLFSLIVIKPVHDAYPDDDDDDDPRGNGTHSNHTDVLVRMGLKRSMNLLEGNGTGGGGNWTVPFFPDNLETDYLWMYVVFAYLFSTILIYLVIATTRQVIEVRQEFLGTQATITDRTIRLSGIPNELQDEERIKEFIENLEIGHVERVLLCRNWKELDDAMAKRMDLLRRLEEAWTIHLGHQRLQRDLETLPIAQAPDQEGNTDDDAGENGNLIGTGGSVIRPFKRPRPMATIRYGRFGLRRKQVDAIDYYTERLREADENVRRLRKQEFAPTPLAFVTMDSVASCQMAIQAVLDPSPLHLIANQSPEPVDVIWQNTYISRRGRVARNWTITALIVFLTVFWSVLFIPIAALLNVETIGKVVPGLAEVLKDHKNIRSLVNTQLPTAITSLFMVLVPYLYYYLSWCQGQISKGDIELSAISKNFFFTFFNFFIVFTVLGTASKFYEVFAKFGDAIRDIQKVAWTMAYSLGRLLNFYVNFIILQGVGLFPFRMLEIGSVSLYPIMLMGAKTPRDYAELVQPPVFSYGFYLPNALLIFIICMVYSVLRSSWQVLLAGFLYFALGHYCYKYQLLYAMDHRQQTSGRAWTIICERIFIGMILFQLTTAGQLILKGALARSVMMAPLLVATIWIMVVYGKTYKPLMKFIALSAVRRNEHYEHYTDVQSNTPEYAASLNSTNLAPETNIWAGGEGRNDMESGGVTLAVRTDEEGARRERNLPFVNPSLVAPLDAAWIADKPTSTQARLVDTGSDDGGDEEEHDGRDGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M3BUR9</accession>
    <name>M3BUR9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UspA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_150103</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016905964.1"/>
    </dbReference>
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    <dbReference type="STRING" id="692275.M3BUR9"/>
    <dbReference type="GeneID" id="27903101"/>
    <dbReference type="eggNOG" id="ENOG502RYEB">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018542_0_1_1"/>
    <dbReference type="OMA" id="PAWRRPT"/>
    <dbReference type="OrthoDB" id="843225at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23659">
        <property type="entry name" value="USP_At3g01520-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47815">
        <property type="entry name" value="UNIVERSAL STRESS PROTEIN A FAMILY PROTEIN C25B2.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47815:SF1">
        <property type="entry name" value="UNIVERSAL STRESS PROTEIN A FAMILY PROTEIN C25B2.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="2">
        <location>
            <begin position="168"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
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        <location>
            <begin position="386"/>
            <end position="505"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
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        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
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            <end position="351"/>
        </location>
    </feature>
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            <end position="410"/>
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        <location>
            <begin position="469"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF11084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="517" mass="56382" checksum="F3F040915F8AD61B" modified="2013-05-01" version="1">MSNEPSPLSGTPVQRAIGSATASIEHSPHSQPSASGTTLLPTRSIPNAPLDGPAAVASFVPAWRRPTNNIDGGSEAVRRPSVQFVPSKSTSGSRSSSANPPSVRRSTGAHASRTTAQLPAGRRLSSPPPPAQFRPSVSFDTFSNPAASDFSLTLNRKHRDYEYTKRSRTFLCGTDTNDYSDTALEWLIDELVDDGDEVVCLRVVEKDSKEASTWSRGQGKAGYRKEAERFLEEIEKKNTDDRAISLVLEFSIGGVQDTIQKMIRIYEPAMLVVGTRGRSLTGYQGLLSSGSVSKYCLQYSPVPVIVVRPSRKREAKKKKRLEDPSRQSYRDILDKSDDAPPGRGTHLLDEKNRLSIMGSELGALGRLDVHDDEARRVAEAIGYRPVANISEPHEPTGGSSSLSRLSSTRSENSTADDVRSPPTRIMKSPSLGIMESPVNSDEEGEFDDEEELTPAAEAMRIARETAMQIRDEVKEDQEERAKRGRSRSRPDDGEESSGGGGAAILDIFEKLNKGLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M3BW10</accession>
    <name>M3BW10_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_150421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759630.1">
        <property type="nucleotide sequence ID" value="XM_016906164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BW10"/>
    <dbReference type="GeneID" id="27903301"/>
    <dbReference type="eggNOG" id="ENOG502RM5T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_621373_0_0_1"/>
    <dbReference type="OMA" id="NDTARYH"/>
    <dbReference type="OrthoDB" id="3902330at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF11509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="441" mass="48992" checksum="04FD41970D206B8F" modified="2013-05-01" version="1">MATGAGWNGEVPRFTDLSGLPEPMEPRKFDSVQQNRAKVGTVLKKQSRFFPTLTTSVSSPIVRLPPTSCKLYRTEEAVTYPPVPETWTNPDNRPSPSCPARNVNTESSLDTESVQPEKSVEHVLEQSASGIASAANLWRILSEDGILTAERIKDDECRADNLRSTWESSEDSGGVPIYEATAQPSMPELDSKEIPYVHLNSLTGHANETGGYHSVADHDTVESVLYPAVFFATPRSITPSYELTATAPRYTPSSPSLHMLEAGSLCTLDQAIIKARPEISDEMKKSVDHFSSEQDLFRPEQVQLPISRPRTPCGLDAFLAMGHVENCWCRDCNETPEMIQKDEIHDDDDDWLDWSTLGDEIDNVSTNTVPQTATVSDVSEEEEHKSSCFPGASTPEWDELYPCTSGQEESQQEFEDEFLGYYDDGAAFARVSDCNWTWTDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M3BW15</accession>
    <name>M3BW15_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_109577</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759635.1">
        <property type="nucleotide sequence ID" value="XM_016900788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BW15"/>
    <dbReference type="STRING" id="692275.M3BW15"/>
    <dbReference type="GeneID" id="27897925"/>
    <dbReference type="eggNOG" id="KOG1577">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_0_0_1"/>
    <dbReference type="OMA" id="ACATNQV"/>
    <dbReference type="OrthoDB" id="5424391at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000025">
        <property type="entry name" value="NADP(+)-dependent glycerol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="5">
        <location>
            <begin position="18"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="4">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF11514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="326" mass="36536" checksum="25FBE9259F91D67B" modified="2013-05-01" version="1">MSSGKTFTLNNGVTIPAVGFGTFANEGAKGETYTAVTHALKTGYRHLDCAWFYQNEGEVGDAVADFLKDNTSVTRSDIFITTKVWNHLHEPEEVKWSLQNSLEKLKLDYVDLFLIHWPIAAEKDEKNMPKLNEKGQYVIKQELTKNPKPTWRAMEELYEAGKARAIGVSNWTIPGLKDLLSWAKVKPAVNQVEIHPFLPNDELVKFCFENGVLPEAYSPLGSQNQVPSTGEKVNTNETLNKIAEKGGNSLAQVLIAWGIRRGYVVLPKSSTPSRIESNFKSIDLSDEDFEAVNQVAKGRHTRFVNMKGDFGYDVWPEDSNIAEVQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M3BX12</accession>
    <name>M3BX12_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_133304</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760717.1">
        <property type="nucleotide sequence ID" value="XM_016902558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BX12"/>
    <dbReference type="STRING" id="692275.M3BX12"/>
    <dbReference type="GeneID" id="27899695"/>
    <dbReference type="HOGENOM" id="CLU_891888_0_0_1"/>
    <dbReference type="OMA" id="ESHNACY"/>
    <dbReference type="OrthoDB" id="3641289at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052783">
        <property type="entry name" value="Metabolic/Drug-Res_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655">
        <property type="entry name" value="QUINIC ACID UTILIZATION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655:SF3">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="26"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF12596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="312" mass="34943" checksum="57AB1421811B67CC" modified="2013-05-01" version="1">MKRDGSNGGGRSEKVKKTLRGRTEKACVRCRAKKRTCDGGNPCMRCQESHNACYFSDWHYTVLYPREYVEYLEEQQEQLSAGIMAMYRLLKDANLHTFSTLSDKPEAQAILAALKESNVDSMALHWSRPSLSNPPGTLFDDGLRIQISEEPTSPREEHCHRLALSPSTHSAVSPIQPASTYMQHFGTAYALVPAPVHHSYSPASYQTFESTPPMQTFMHPQMLAVQTQTLPQAVPTRPDMLFPCSACTGIVQIPEPWRPSLSSFTPSTSASLERVSDQPPTFVGPTGTHSTETAHENMCIYYQTDHDLRPWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M3BX82</accession>
    <name>M3BX82_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_149280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760802.1">
        <property type="nucleotide sequence ID" value="XM_016905458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BX82"/>
    <dbReference type="STRING" id="692275.M3BX82"/>
    <dbReference type="GeneID" id="27902595"/>
    <dbReference type="eggNOG" id="ENOG502SA9I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022553_0_0_1"/>
    <dbReference type="OMA" id="FAEYHLS"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF12681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="806" mass="91105" checksum="2C53B6638052C349" modified="2013-05-01" version="1">MLSFPLRRAQIELQSHRNWLRTFVVRSRHGETAFNKNGSVRLFTSSHRHGDGQDQEYEDEQKQERKQEQTRKKWNAIARARYKADAEQWRNKDGEQAAEGSEATAGSRRLSDAQRRKRERWEARRAGPQTYQFKAFGLREDLLTAVKENNTAAVFRLYRDLPEKKPLVAEDFRAIAQCTHQALRTENQQPQQLQQSERKQAIVGFAELLVKDIRHGNLVPSKRAHTHLLGIFKESGYLDSGIMFWNWLEPQDDQHVGHETYGAAIELLAIHGTPLEDLESLYSRALARFPGNFSAYHMSPNAMLPDREASTAVKGLPVSLLQAITTARLMRGDSRRAYLALDTVFRLFPAAVESRFIKLFLEERPVSEAYAVFALACRAGLVLPSVVFRTLLPKLRAAAESRSAQHHIASLRAMLTATHLQLGATGKVVPNNVAELIITTTTIFRRPGVDKLEGKQRKRLVDAILLFVRQMFETFARFGVLPSPAALNSILINVAGYGRSKETLGIVLKDFEALKMTQNEVTRRTVLAIAGMWGDQAMIEESWSKIIEARRAKDQWPDPTDFFVLSKSVRATGKVSFAREQFDTLKMFIPQSHHSSIDYAITQAYEPDTDVASGHEQVSFAELYEGIEKLNADLAVLELETRDRPAVQDFSDKHLCLTLLPPEGALKASEAVMRQVYDEMTADPGTRAAVVHDSTTDADVDDRTFGRVVRSATNITLGDLRYETWKNINNLLQLAEKHDVSYNEIVDRCIAEGKRPPKREMGFTETEMSSMSGIGLSEVAARHKKSEVTVEEYRAEVKRLRGMDSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M3BY48</accession>
    <name>M3BY48_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_117525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761107.1">
        <property type="nucleotide sequence ID" value="XM_016901346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BY48"/>
    <dbReference type="STRING" id="692275.M3BY48"/>
    <dbReference type="GeneID" id="27898483"/>
    <dbReference type="eggNOG" id="KOG0005">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010412_6_4_1"/>
    <dbReference type="OMA" id="YAGKQMA"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031386">
        <property type="term" value="F:protein tag activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01806">
        <property type="entry name" value="Ubl_NEDD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000023">
        <property type="entry name" value="NEDD8 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038738">
        <property type="entry name" value="Nedd8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF12986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="89" mass="10068" checksum="7D5D5190C4F6617A" modified="2013-05-01" version="1">MQIKVRTLTGKEIELDIEPDYKVQKIKERVEEKEGIPPVQQRLIFGGKQMNDDKTAEEYGLEGGATLHLVLALRGGCSVQKESSLRRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M3BY69</accession>
    <name>M3BY69_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Trehalose-6-phosphate synthase</fullName>
            <ecNumber evidence="6">2.4.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">UDP-glucose-glucosephosphate glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_149516</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>D-glucose 6-phosphate + UDP-alpha-D-glucose = alpha,alpha-trehalose 6-phosphate + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58429"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="2.4.1.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.15" evidence="6"/>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF13011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761132.1">
        <property type="nucleotide sequence ID" value="XM_016905602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BY69"/>
    <dbReference type="STRING" id="692275.M3BY69"/>
    <dbReference type="GeneID" id="27902739"/>
    <dbReference type="eggNOG" id="KOG1050">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002351_7_1_1"/>
    <dbReference type="OMA" id="NRTIWPL"/>
    <dbReference type="OrthoDB" id="755951at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005946">
        <property type="term" value="C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000007">
        <property type="entry name" value="Trehalose-6-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000035">
        <property type="entry name" value="Trehalose-6-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012766">
        <property type="entry name" value="Trehalose_OtsA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02400">
        <property type="entry name" value="trehalose_OtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF106">
        <property type="entry name" value="BCDNA.GH08860"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="491"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="529"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF13011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="539" mass="60772" checksum="7B122FF629130D64" modified="2013-05-01" version="1">MPSFEETPAPKGRLLLISNRLPITIKRSDEGHYDFTMSSGGLVAGLSGLSKTTEFQWYGWPGLQVPENELGLLKQRLRDEHSAVPIFMDDELSDRHYNGFSNSILWPLFHYHPGEITFDESAWDGYVEANRIFAKEIAKDVQDNDLVWVHDYHLMLLPAMLREEINKAGANKKKNVKFGFFLHTPFPSSEIYRILPVRNEILQGVLHCDLIGFHTYDYARHFLSACARILGLATTPNGVEFQGKLITVGAFPIGIDPEKFVLGLQKENVIRRIETLKKKFDGVKIIVGVDRLDYIKGVPQKLHALEVFLTEHPEWIGKVVLVQVAVPSRQDVEEYQNLRAVVNELVGRINGKFGTIEFMPIHFMHKSVSFDELTALYSISDVCLVSSTRDGMNLVSYEYIACQQERHGSLILSEFTGAAQSLNGALVVNPWNTEDLADSIHDAVTMGEEQRTMNYQKLAKYVNKYTSAWWGESFVSELTRISEQAEKKLKVRQSNVLDPAGTAIDDSFPEDKKEGTSQPAVADTTGESQKVEASDQETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>M3BYP5</accession>
    <name>M3BYP5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_148565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761312.1">
        <property type="nucleotide sequence ID" value="XM_016905002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BYP5"/>
    <dbReference type="GeneID" id="27902139"/>
    <dbReference type="HOGENOM" id="CLU_1939449_0_0_1"/>
    <dbReference type="OrthoDB" id="3642611at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF13191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="130" mass="14599" checksum="F5381CCF51D4F214" modified="2013-05-01" version="1">MCRGTYIVSYSCGHVIYTPSVCLQEVAPHYRCEPRGMKITQPPARCVECYSRELEPNQNLPTSARFKPDLNARENMEFEARVTHLARDSEESSRSSADSQAVAEIARWVMTLPSAPLSPSAAEQTSFMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M3BYW1</accession>
    <name>M3BYW1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_125104</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761387.1">
        <property type="nucleotide sequence ID" value="XM_016901953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BYW1"/>
    <dbReference type="STRING" id="692275.M3BYW1"/>
    <dbReference type="GeneID" id="27899090"/>
    <dbReference type="eggNOG" id="ENOG502SJUN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_376430_0_0_1"/>
    <dbReference type="OMA" id="QPAPMDQ"/>
    <dbReference type="OrthoDB" id="10261408at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053187">
        <property type="entry name" value="Notoamide_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="124"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF13266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="673" mass="76007" checksum="5ED2E3D63CC03002" modified="2013-05-01" version="1">MASSLTKSSASKRRDQVTVACDRCRSKKTKCDGTRPICSSCARRRTLCVWDSERDPDATPITAVKRKLEQIQPQLLQYQALFSLMRESSDAEALRVLSAVRSGSDIESALQAVRFQVSPERLEISAGRQTGHPPKKCHGSRSDSRHSERVAQMDGGDKQPYLRRVASQETAPESKCRRHLSAPWQDGTFSDYDPRIQAAHSNDWGLTYLDDETFRNIIRCFLTWDHPSFTFFDEDLFLDQLAKGQPSELCSSLLIHAMMALGSRNFYFLEPDKAAIAEHFGLAAATQQWDMCHDDAIPAVIIAGMLLFLVYQFKGQDKFGWPYLAQAEQLARVLGFFRPAMAHKTFDRSAQHAVRTRGRQAVAWGIFDYRAYLSLINDLQPMTDCPAIPIMAEPESEADDIWAAWPWPGTCRQFPGQLQYARSTLSLIVADIMPVHRRHETNNVTKAHHDAALAIYERLRKWYHELRQPLKSLRVSTPQLIGLHNYYQLALMQLFSPFVLEPDGPTSFLPSSKPLREAGLPDELMTATYFAALEQLKTNIFHFDRQWSPQCTPSQNLAPLVHVCLAALPVLHSDLDARYIFSLGLLLCLRAAQSFVICRAILRSIQATAVRKGVVLPALAHRVFARLDHAFPALPHLDKVRSTFIVDTRLRHTDVEASTLETLVKDMVGLHVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M3BZL7</accession>
    <name>M3BZL7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycoside hydrolase family 43 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_43533</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761617.1">
        <property type="nucleotide sequence ID" value="XM_016908899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BZL7"/>
    <dbReference type="STRING" id="692275.M3BZL7"/>
    <dbReference type="GeneID" id="27906036"/>
    <dbReference type="eggNOG" id="ENOG502R8XS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009397_2_0_1"/>
    <dbReference type="OMA" id="LFQHRMY"/>
    <dbReference type="OrthoDB" id="272289at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18820">
        <property type="entry name" value="GH43_LbAraf43-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43817">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43817:SF1">
        <property type="entry name" value="HYDROLASE, FAMILY 43, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032165" evidence="6">
        <location>
            <begin position="23"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF13496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="296" mass="31981" checksum="3BC091C1308CA4D4" modified="2013-05-01" version="1">MRLTIFSSAFAVLSCMLGVVSAASYSNPLRTSNGGDPNIVFHEGWYFMMATNFVDLRMTRARTLDGLKNGETKLVWADSTPSRCCNVWAPEMHFYSYAGQLSTPGWAIDGTILRAANKIYFVYSAFLGGGFEQGGKQSLYITPLTGAVKTGEHKLLSQPTQSWELVGNPVNEGPSAIYHGGKTFIAYSGSYCWTSSYAIGTLEWNGGDPMLASSWKKSGPHFSSANGEYGTGHNSFFTSPDGKEIWNVYHSTPDSGGNCGERRYANAAVVRWNGDGTPNFGVPAGYSAMRPGPSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M3C088</accession>
    <name>M3C088_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP synthase subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_148940</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="11">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase gamma chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761862.1">
        <property type="nucleotide sequence ID" value="XM_016905241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C088"/>
    <dbReference type="STRING" id="692275.M3C088"/>
    <dbReference type="GeneID" id="27902378"/>
    <dbReference type="eggNOG" id="KOG1531">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050669_4_1_1"/>
    <dbReference type="OMA" id="MQITSAM"/>
    <dbReference type="OrthoDB" id="239812at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd12151">
        <property type="entry name" value="F1-ATPase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1380.10:FF:000003">
        <property type="entry name" value="ATP synthase subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.80">
        <property type="entry name" value="ATP synthase, gamma subunit, helix hairpin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035968">
        <property type="entry name" value="ATP_synth_F1_ATPase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000131">
        <property type="entry name" value="ATP_synth_F1_gsu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01146">
        <property type="entry name" value="ATPsyn_F1gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693">
        <property type="entry name" value="ATP SYNTHASE GAMMA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693:SF22">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT GAMMA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00231">
        <property type="entry name" value="ATP-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039089">
        <property type="entry name" value="ATP_synthase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00126">
        <property type="entry name" value="ATPASEGAMMA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52943">
        <property type="entry name" value="ATP synthase (F1-ATPase), gamma subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="9 11" id="KW-0139">CF(1)</keyword>
    <keyword evidence="4 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF13741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="305" mass="32910" checksum="E1623FAEF0A4BE0D" modified="2013-05-01" version="1">MLSRAARPALRAGAAQSLRPAAATTPALQAANYATLRQIESRLKSLKNIEKITKTMKIVASTKLTKAQRAMESGRSFGQTSGKVFEEAETKALESENKKVLLVVCSSDKGLCGGIHSGLSRAVRRLVESEPADYNIVCIGEKSKAQLSRSNPKALVLSFAGVGKDVPTFADASAIADQITLLPSEYASVKIMYNKFINAQSYEPTIVEAYSEEAITQSPGFSNYEVDDSVLSNLREYALTNSLYWALAEGHACEISARRNAMDNASKNAGEMIDKFQILFNRTRQAVITGQLVEIISGASASEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>M3C461</accession>
    <name>M3C461_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Pre-mRNA-processing factor 19</fullName>
            <ecNumber evidence="16">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">SEPMUDRAFT_59450</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21 22">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 16">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the WD repeat PRP19 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="16"/>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763172.1">
        <property type="nucleotide sequence ID" value="XM_016909492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C461"/>
    <dbReference type="STRING" id="692275.M3C461"/>
    <dbReference type="GeneID" id="27906629"/>
    <dbReference type="eggNOG" id="KOG0289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023894_0_1_1"/>
    <dbReference type="OMA" id="SLDQHWA"/>
    <dbReference type="OrthoDB" id="687049at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070534">
        <property type="term" value="P:protein K63-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16656">
        <property type="entry name" value="RING-Ubox_PRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000027">
        <property type="entry name" value="Pre-mRNA-processing factor 19, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038959">
        <property type="entry name" value="Prp19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013915">
        <property type="entry name" value="Prp19_cc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055340">
        <property type="entry name" value="RING-Ubox_PRP19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43995">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43995:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08606">
        <property type="entry name" value="Prp19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5 16" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="12 16" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="14 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0697">Rotamase</keyword>
    <keyword evidence="7 16" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="6 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 16" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="4 15" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="U-box" evidence="18">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="279"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="327"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="127"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="132"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EMF15051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="480" mass="50765" checksum="977912935FDCB608" modified="2013-05-01" version="1">MLCAISGEAPQEPVASRKSGNVFEKRLIQAYISEHGTDPVNGEDLTVEDLVDLKQPRTVKPRPPTLTSIPALLSTFQNEWDAIILEAYQLKQQLAETRQELSTALYYNDAAQRVIARLQKERDEARDALSRVSVSGTSNGTNGTSGDAMQVDNQPLSGNAVMKVTETQERLSGTRKQRVVPQDWATGEQLESFDVTTSVDTQFTGAKHLSTDATGDFFLTGDSDGTMGIFDLAAGAFTTRSNLGAGAILSGAWANDKQAVSTANGTVVVAQEGAIQGKFQQHAGAATALATHPSGELLASAGYDKSYIVYDLSTMHVLTQVFGDIELTSIAFHPDGHLLAVGGADGSLRLYDVKSSQLAHTFPSPAGASPVVAIAFSENGTWLASANAGQTALTVWDLRKLKALRTIDVGTAVTGLSWDFTGQFLAASGPGGVTVSHYTKSSKTWSTPLSKALNAVDVKWGSKASSLVALTDSAIVVLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M3C7A1</accession>
    <name>M3C7A1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_131673</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SYS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF16141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764262.1">
        <property type="nucleotide sequence ID" value="XM_016902441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C7A1"/>
    <dbReference type="STRING" id="692275.M3C7A1"/>
    <dbReference type="GeneID" id="27899578"/>
    <dbReference type="eggNOG" id="KOG4697">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081382_0_0_1"/>
    <dbReference type="OMA" id="EYEMVGM"/>
    <dbReference type="OrthoDB" id="542931at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019185">
        <property type="entry name" value="Integral_membrane_SYS1-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12952:SF0">
        <property type="entry name" value="PROTEIN SYS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12952">
        <property type="entry name" value="SYS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09801">
        <property type="entry name" value="SYS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="68"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="182"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF16141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="23115" checksum="3C112CDF7997579C" modified="2013-05-01" version="1">MPTLRRRRPPRPGALADLSPLRILTQILFLQLFYYGIAIVLIVFITLVEGEHVQPGMIFDWSYLRGDVTTGWTLGLCWMLDSLGMVIPILLLIARSKLVPDFALTIHFINLVITALYTRSIPSTLAWWVLQIFSAGLMISLGMWACQWRELRPMAFGGRSKDTTSGAASANVAPELEAGEGYEMGERRGGGKDGAGTYEMVGLASKDHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M3C7C4</accession>
    <name>M3C7C4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription elongation factor Eaf N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_147805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF16166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764287.1">
        <property type="nucleotide sequence ID" value="XM_016904535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C7C4"/>
    <dbReference type="STRING" id="692275.M3C7C4"/>
    <dbReference type="GeneID" id="27901672"/>
    <dbReference type="eggNOG" id="ENOG502SEGQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_601261_0_0_1"/>
    <dbReference type="OMA" id="VDSTFHM"/>
    <dbReference type="OrthoDB" id="125903at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019194">
        <property type="entry name" value="Tscrpt_elong_fac_Eaf_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09816">
        <property type="entry name" value="EAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription elongation factor Eaf N-terminal" evidence="2">
        <location>
            <begin position="18"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="300"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF16166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="421" mass="45196" checksum="136F993F8BB85328" modified="2013-05-01" version="1">MAAVHGLIDLSGKSQAVFPIRLGASITKPSDGTHFASIRYNHKPALKPTEDVKASIGHGPNGNELLLEAGSGRYAYRGEYRQDVGTFVLVERGEGQDKEMVLERLDGMHTFNLISTPAQSNAAKLEQMYPHLSEAPAEDDLFGDDDEDSPPDASNPFDYRHFLKAELEKQEPVVEPGRSTLGTPVVQPVARSTPGARAVKPAAKSKAPAKRKTAADKSNTKRVKAGQEPATVPPPVKSNPSKAKPDIPKVRMDRKASVRKPSIDDSGELILENETPVTEKPPRAAGAMAWALNGALNTGPISLASAASSPGLASPAPEKGEEAEQEEIQEYEFDFGDGSDVEDEEDQSELVLENGDDDGELVLEDDDADIEEPLELPSPAQAHRPSVSKAVAPGEDEDDDIEKQLALAMAADDEEEESEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M3C9Y5</accession>
    <name>M3C9Y5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_92721</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756791.1">
        <property type="nucleotide sequence ID" value="XM_016910591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C9Y5"/>
    <dbReference type="STRING" id="692275.M3C9Y5"/>
    <dbReference type="GeneID" id="27907728"/>
    <dbReference type="eggNOG" id="KOG0684">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1012538_0_0_1"/>
    <dbReference type="OMA" id="FMANTPE"/>
    <dbReference type="OrthoDB" id="3168162at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050529">
        <property type="entry name" value="CYP450_sterol_14alpha_dmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304:SF2">
        <property type="entry name" value="24-HYDROXYCHOLESTEROL 7-ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF08670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="275" mass="30271" checksum="56CEEC86FA4BDB87" modified="2013-05-01" version="1">MAWYQRGGLESASEEMKAIVRVFEAAGSPPDVGSKFLNMMVVAFMANTPETLGWLFVYVTQAPALCKVIREECDALGEGEDLVQVNFKVATPHLYSAFFETFRQCVFTGTPATVIRPCTLPGIEDHVFQPGDILHSMAEACAMDADVYGPDVRYWKGHRFVGEGDQLLKYDLTFGLGRSPCPGRNFAIAELCMLAARMFQTFDFSEPSVNKRLSFSDGDFELHEPVKAETVDIIDLDGQIRTILYPGNASDTGVPGMTAANIPANDFACRLTPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M3CB07</accession>
    <name>M3CB07_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_151877</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF09015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757136.1">
        <property type="nucleotide sequence ID" value="XM_016907099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CB07"/>
    <dbReference type="STRING" id="692275.M3CB07"/>
    <dbReference type="GeneID" id="27904236"/>
    <dbReference type="eggNOG" id="KOG1875">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003573_0_0_1"/>
    <dbReference type="OMA" id="ITQGYIP"/>
    <dbReference type="OrthoDB" id="205099at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055122">
        <property type="entry name" value="Med14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013947">
        <property type="entry name" value="Mediator_Med14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809">
        <property type="entry name" value="MEDIATOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08638">
        <property type="entry name" value="Med14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit MED14 N-terminal" evidence="11">
        <location>
            <begin position="104"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1033"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="39"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1085"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1100"/>
            <end position="1112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF09015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1125" mass="125724" checksum="B8797FFD903D6ED8" modified="2013-05-01" version="1">MPGRLIMDQQGPVGSQDLKKDRGQAHEGVTSQKRDFAQMQGTAHANGSANGHPNGQSLANGVNGQHQLSTATSGHSNGTPTAVSSLPTPPPLDQSWRSSDANKPMGVMLQRLAQQCFADLNDTCNKMSQMPPPPPAAANGVVPHINDPSRESVERKRVWMDFANGQRDRFIKALVLSDWARSEHDMAKLVDLKVWQEKQSRAQDAAKRFIGEIKHGVVAAKMRNPNIEDAMELLATGKSSKWPDLMWIPPKKLPAKRLVATLNDMNVMLATRLNLHEELPLHFRDYSIANGRATFRVPGEFEVDLSIAEEDPSSQFYLIDLRFTFTPTPSISDPLRNALEAQTNGALSSKGLQGCYEFLHNFVLTHKINVFRSQAVKLFREKWFGCLVTETQRRVFAIHYWRDQAGKKSWIEFGINTGKVQGKRMRKAPTARHSVRWFRHGQEVQDDSIEIDWNNLDLDAILTQVIAKHASWTLSTVEKRLRTYAGTASTLHSELCTSASNPGACKLGLSLPGLRTAITLRLEPVTGLMTIFPESRDAATAERNFNRNPIVDNSASFTQLLCRAVQDRVRRAVISSGWQLADLRGFGAQPNFKALFGQGIVRSDILHCARGWKDWALCTTYSLSGQNWWAVRLNKQAVEQGKTVTTIAEARAINVSATGLCRADLSRIRRLAEAEISFAVLAHDLEANQIPHHIDSLSSPQLHSDTTSLQQDSAVAVYLRLTPKDLKSSVLTKYKSLSITNWVRIAYQGIVDEDEETAHVRHDIRLTVDSEKLKHLHDYFTNSKVRDADIAMNGSGGLALSLRTPLGQPYVTKIIALLDRCRELNEVLLTAPRLQFTCTTVGLQKITFTYGAMHQYIGSLVTNGSGTLLKLDPPFTNPHQRIRVLLERLYNKARDHKFWALALAMNAVQPLLESLVNLETSHAAQHTLLIHSHDVSMHTVEYRSPFIPCRFKASVQWYRAEGGRRQHRYTITPHQREGVEMPAAFSNALDELSRNCGSTAEGWFGNNKGGYTATHPKGLPTVFRRLDDFMRTSGQASDATVNKVEKQETPVPNAKPTLNRNPSKHNVSHQQKPNGQTQPKPQPRPQQQNQSKQSYKPHDSTANQTLKPNQKSGKTKQEQEVIELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M3CBI7</accession>
    <name>M3CBI7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_150932</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF09792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757913.1">
        <property type="nucleotide sequence ID" value="XM_016906483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CBI7"/>
    <dbReference type="STRING" id="692275.M3CBI7"/>
    <dbReference type="GeneID" id="27903620"/>
    <dbReference type="HOGENOM" id="CLU_1644767_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="94"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF09792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="161" mass="17094" checksum="99124FA26DCE25A9" modified="2013-05-01" version="1">METATRTMEKVVQPLISAIADAQKLLLNSAHEAIFGGEKDLLDAGFSDGGDMSDIELEAISSKVKALKKLVMVPQADWNKNEIAAATSALTEARAEWNKKASAVEAEKEKAEEARKKKAQEFVDLQAQLLQEAESANAEKAAATDGSGGAAPVSTPVLPMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M3CFK2</accession>
    <name>M3CFK2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">L30e-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_149225</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760724.1">
        <property type="nucleotide sequence ID" value="XM_016905427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CFK2"/>
    <dbReference type="STRING" id="692275.M3CFK2"/>
    <dbReference type="GeneID" id="27902564"/>
    <dbReference type="eggNOG" id="KOG2988">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130502_0_1_1"/>
    <dbReference type="OMA" id="YFQGGNN"/>
    <dbReference type="OrthoDB" id="1928736at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030627">
        <property type="term" value="F:pre-mRNA 5'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048025">
        <property type="term" value="P:negative regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000001">
        <property type="entry name" value="60S ribosomal protein L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00481">
        <property type="entry name" value="Ribosomal_eL30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000231">
        <property type="entry name" value="Ribosomal_eL30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039109">
        <property type="entry name" value="Ribosomal_eL30-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022991">
        <property type="entry name" value="Ribosomal_eL30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002172">
        <property type="entry name" value="PRK01018.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11449">
        <property type="entry name" value="RIBOSOMAL PROTEIN L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00709">
        <property type="entry name" value="RIBOSOMAL_L30E_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00993">
        <property type="entry name" value="RIBOSOMAL_L30E_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="4">
        <location>
            <begin position="12"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF12603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="109" mass="11631" checksum="D080B47011B33F00" modified="2013-05-01" version="1">MAPKKSNKTSDSINAKLALTIKSGKVTLGYKSTLKTLRSGKAKLVIIAGNTPPLRKSELEYYSMLAKTAVHHFSGNNIELGTACGKLFRCSTMAILDAGDSDILSTTPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M3CIF0</accession>
    <name>M3CIF0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_148844</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761719.1">
        <property type="nucleotide sequence ID" value="XM_016905183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CIF0"/>
    <dbReference type="GeneID" id="27902320"/>
    <dbReference type="HOGENOM" id="CLU_2518822_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF13598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="85" mass="8862" checksum="6B3F95E56C1BD21E" modified="2013-05-01" version="1" fragment="single">MPSCRRCSGQGQVPKPCNSCNSTGHTRQRMRCYQCKSKDAPTAAACTLCRGRGQLMIPVNCTNCSGSGTALRLTCGDCGGSGRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M3CIG6</accession>
    <name>M3CIG6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase family 13 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_132876</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761734.1">
        <property type="nucleotide sequence ID" value="XM_016902520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CIG6"/>
    <dbReference type="STRING" id="692275.M3CIG6"/>
    <dbReference type="GeneID" id="27899657"/>
    <dbReference type="eggNOG" id="KOG0471">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006462_2_3_1"/>
    <dbReference type="OMA" id="PNGEKWA"/>
    <dbReference type="OrthoDB" id="1740265at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033934">
        <property type="term" value="F:glucan 1,4-alpha-maltotriohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004574">
        <property type="term" value="F:oligo-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000025">
        <property type="term" value="P:maltose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11333">
        <property type="entry name" value="AmyAc_SI_OligoGlu_DGase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.400.10:FF:000004">
        <property type="entry name" value="Oligo-1,6-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000087">
        <property type="entry name" value="Oligo-1,6-glucosidase IMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="entry name" value="Oligo-1,6-glucosidase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF179">
        <property type="entry name" value="NEUTRAL AND BASIC AMINO ACID TRANSPORT PROTEIN RBAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="3">
        <location>
            <begin position="20"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF13613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="593" mass="67939" checksum="07FAEE2DAE758E69" modified="2013-05-01" version="1">MSDTSSSSSDSWWKSGVVYQIYPASFQDSNDDGIGDLQGITQRLQYIKDLGATIIWICPMYDSPQHDMGYDIRDYKKVYEPYGNISDMTTLLSTAHSLGLKVLLDLVINHTSNEHAWFRESRSSRTSPKRDWYIWKPARYDAQGNRHPPNNWGSYFGGSTWEWDDLTQEYYLHLFAKEQPDFNFETAEARKALYADSIEFWLNLGVDGFRVDTCSLYSKNQNFPDAPIRDPAEEFQHAGATVNHGARIHEFMKEMGEIISRYDAMTVGECGNAGEVEHTLKYVSAKERELSSVFLFDVVNVGHGRPNRYTVPPRSWDLPTLMGAIETTQRVFLGTDGWTTTFFENHDMARSISRFGDDSTPEAWSASGKMLAVMQATLSGTMYIYQGQEIGMINIPLTWPIPSEYKDIESQRWYDFLHQQFASHKDPSKLALGILSMQHLARDNSRTPMQWTPDLPNARFTGEHVKPWMRVNDGAATKERINVACQEGVEGSVLEFWKRMLRMRAERKEVFVFGEMELLEQERNNEKVMAFVKKSLSGDLVALVLCNFTGETQPLPHYEMAGEREVLVCSVEEPQENVLMPWEGRVVLIKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M3CKZ2</accession>
    <name>M3CKZ2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">3-hydroxyanthranilate 3,4-dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_148148</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762559.1">
        <property type="nucleotide sequence ID" value="XM_016904737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CKZ2"/>
    <dbReference type="STRING" id="692275.M3CKZ2"/>
    <dbReference type="GeneID" id="27901874"/>
    <dbReference type="eggNOG" id="KOG3995">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095765_1_0_1"/>
    <dbReference type="OMA" id="INQTEEW"/>
    <dbReference type="OrthoDB" id="204928at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000334">
        <property type="term" value="F:3-hydroxyanthranilate 3,4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046874">
        <property type="term" value="P:quinolinate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010329">
        <property type="entry name" value="3hydroanth_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15497">
        <property type="entry name" value="3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15497:SF3">
        <property type="entry name" value="3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06052">
        <property type="entry name" value="3-HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF14438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="114" mass="13395" checksum="8FD052E49F5602C9" modified="2013-05-01" version="1">MLLRVIENDRFRNIEIHEGDTFLLPGNTPHSPIRFADTIGMVMERTRPEKSVDRLQWYCSKGEHERPTMIREEVFHCTDLGTQLKPLIEKWQQDESSRKCPECGEIEDAQLVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M3CMD7</accession>
    <name>M3CMD7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_79113</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF14953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763074.1">
        <property type="nucleotide sequence ID" value="XM_016910211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CMD7"/>
    <dbReference type="STRING" id="692275.M3CMD7"/>
    <dbReference type="GeneID" id="27907348"/>
    <dbReference type="eggNOG" id="KOG1293">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_474033_0_0_1"/>
    <dbReference type="OMA" id="EHECAIV"/>
    <dbReference type="OrthoDB" id="5559898at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038739">
        <property type="entry name" value="ARMC8/Vid28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15651">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15651:SF7">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="435"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="440"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="451"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF14953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="664" mass="72442" checksum="B7D1C0BEE328B65B" modified="2013-05-01" version="1">MLSARNGFASPYESKLPPLHIPAFKTVSHSPASSAFPALKTLQGSKHGSGNGNAEISNLVSDIDHSNAVCGWLLVLTRSLRGYDRLSALRLLALTEFGQKTKERHRQLALLAVPLAVQLVQIANDGKVTDKALDHQTLKVIKEQACSVLALLIGGVRELQIAAVEAGAVKHVCPILKKSFDNVTPARPMWSVSSSMQPNANASISCQPGKITFPPEVGHAMRCRESALRGLEAIAAREDIHRKAIIDSGVVTCIIDSLKPLPEHTQFDAHGRIKLTPKDGNTTRVILAACRAAQSMSRSVSVLRTSLIDGGIAKPLITLLNHESLEVQIAATDVCCNLLPDFSPMREDLSEGNAIRTFAEHARSSSPALRLSSLWALKHLVYNCPKETKLAALEELGTGWLVGIIQGEQRESVGGGVSVGLSTPNAAGEQVDLLNPSSMDLDEPSNDAEEASSTHYQSSQLRSTLNPPPPAFNSKRYLSSIREMEQGGEYTSRRDEAAIQQQALDFLRNFINGEDCTALSDHLMNEIGSAKVYELLTSKLSPVTRSGGRQVYNTTDLVLSTIHVLIHLANASAKHRQLLVAQRPLLQAMLPHFNHVDHRIRVMSVWAVNSLTFIEDGDDRRDARQRSQELKSVGIEQAVRNLQNDSNLDVRERVKTAIRQFEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M3CP03</accession>
    <name>M3CP03_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_123789</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763629.1">
        <property type="nucleotide sequence ID" value="XM_016901862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CP03"/>
    <dbReference type="STRING" id="692275.M3CP03"/>
    <dbReference type="GeneID" id="27898999"/>
    <dbReference type="eggNOG" id="ENOG502STGS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_271575_0_0_1"/>
    <dbReference type="OMA" id="DTGIHAG"/>
    <dbReference type="OrthoDB" id="1918685at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Chromo" evidence="6">
        <location>
            <begin position="29"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="465"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="518"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="594"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="465"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="518"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="594"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="81"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="383"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="568"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="106"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="189"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="204"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="262"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="285"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="384"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="442"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="575"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF15508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1206" mass="133975" checksum="408E4DC7FB260484" modified="2013-05-01" version="1">MSPKLFYTDSEDDSIGTEYTTQDDGDGLYDIEKILSQKDNYFLIKWQGYATPEATWEPRDGLPPDDSEIWVEWRRHLKAVRDGREQAFDQHQWQKEWEKHRDEKNRRRARRNAKRRKKNLPTRPDTLEEESTHAADSHEEEDSEDDAPLALRTANRRAPPQQPVHRKGVAQKLTKPRREQRNASSSSDESAEITSDDSEESLVVTGSQKVKLRSPSSIKRPSREDVRRKRSQTSSVVSPKKQRLNSHSKSQVTQDERIHEAQPQQRPSAPMRTQSSQSAIPRKNVPSSSASVALPARAKKSKNVMSNWDGEAKKRKRVPKVGSVVDETARPGFLHLRMQHAVQKSTREEGAPDLSALNIIDPKTGNVVVPSKVSTASVAAAEQSATKTATGTSTAPGVTASTPPATIVSGIDGAYSRRSPPPSARNPEALPVRSTEGSASDLRAENTSEHQHSATSGDANASLSIRKTAICRFWREGTCKHSAQNCSFAHSFAAGDATKIGGEYASKLRLPPPDERYDPGQLRCHFFRTHGICKRGAVCKYAHHDTPYDAPPPGVTVEDVRASQLVYAQSTMSRDPQKTRKRPDSGKQHSSDLTCYFWRTQNSCKKGKYCPFSHSDTGFNAPPPPGILKNMLRSNEAPEPRTNLAPMGNHRWTSGADAEVPRQSFDRPVFGEPQYAKVPEATPARMGFHGASDLVLSPEPLIASPMHTSLPGPQISPESGNSLWDVGSASAAVITRSAMLKLYHQGSEHPHSIRLTLDVFGDDMFTRMVGDSPVLCAEHAILTSDVQAVLWQDIQNSSNAASAVIHMDVSPKHEVSSAAELCKLHECCLLASVEGYSATNILVYPSNAEQWKFLDTPGLPSDSSASLKLCAFDGCPDLRRRLSSRLTPMRLDPRSPALIVGEVLAQVERSRIFDKGVEAVFLMIPPAHAAELDFLKQVFVEMKCRVYHAGMPGSWSYFCKRYDRAGVVLVHPNTPLWRIPKLHEMTLRPTSFFTIGIDHTAALLDDREDVFECTRLFPLGGAALLTDDLIAHYPEEATEIIQNFLNATSSKPEGAEVYKIVARPGLKRFLLENFIERGRPDERWLRLYGAVCDLCPPEDEDLEDPPNPLATSHLVSINPDLLPSFAGLWERDQEAAADVLVEWFAGWALLHASRFRKFAVITGTGADDRGWALRYRHIGVMRPEQAMKYVIRGNKPQKGIRNWKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M3CVE9</accession>
    <name>M3CVE9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="6">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_152403</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="6"/>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF08127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756248.1">
        <property type="nucleotide sequence ID" value="XM_016907425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CVE9"/>
    <dbReference type="STRING" id="692275.M3CVE9"/>
    <dbReference type="GeneID" id="27904562"/>
    <dbReference type="eggNOG" id="KOG1871">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008279_3_0_1"/>
    <dbReference type="OMA" id="AMIMFMK"/>
    <dbReference type="OrthoDB" id="429671at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF687">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="455"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="94"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="213"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="589"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="847"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="880"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="286"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="348"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="363"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="589"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="880"/>
            <end position="893"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF08127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="920" mass="101492" checksum="3A1BB82EAEEA196B" modified="2013-05-01" version="1">MNNHPYQGGHGANAPPSALPLHPQRRDFVPYAQQHVAQHTGIVQPYPTYHPAASFYHTQPPRWQPNYQQAYPQHFMQPQQWMPPQHFAQRSPMIVSSQPHGQPVTRQQHPIPPIPQSTQSPRPVPQYIHHQPPAASPSPAPAQVPTPVPVPAPVPAIAPKPEERLETPPPPESRRQSIAQSPLSLDPEYRDQFWPPGGLPWYSVSEDRAVFPTRATTRRRRRRNLRGGNTSVALPTREDTEQEVSAVEKASAPVAEVPQTPSAEEPEPEPQSEVSTIAAPSEPETPATSQAPSESDFTNSTVTPAHAPVPSPKPLPTQQPSRARRDTRTAIAVPSIPGLARPKDASPPSVSQKGAQSQAGEEATLKPEEQRDTIAEEASPVVDSVKPAESKPAPKSSWADMVKRNAPKGPPPARGPPKGDVVTNGFHLPKSASLADALKQYTVDSGTHLNFLEPRGLVNTGNMCYMNSILQVLVFCVPFYNFLDQVAKRTVHSMKSDTPLVDAMIMFMKEFKPLATAASADAVRSLLKQEQLEQYGDSVTPDYVYEVIRNLSRFANMRRGHQQDAEEFLGFLLEELHDECVKVMLGQTEQQPQTNGAASPETVLSPSSADGWLEVGPKQKSVITRTTGQQDIASPITRIFAGQTRAEFRVPGQKDSVTLEPYKPLQLDIGGEHVSNIVDALKGLTNTETLTGEFGGRGNTAKKQMFIETLPPVLILHLKRFEYNSSTKATQKIWKKVGYPLELQIPKEVFSPAKRAGLQISGLPKYRLTSVVYHHGKSAAGGHYTVDVLRQDSREWIRMDDTIIRRIRSEDVAEGGSEEDPKVLARALEQHKADQDMQKQRNMYQGLDEAEKEPEEEKPWSEVNGSITSHKKNWSGVAASLTNGTATPSSTAGKRTPTAKKEGVRDNKVAYILLYERIRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M3CX18</accession>
    <name>M3CX18_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_121709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF08221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756342.1">
        <property type="nucleotide sequence ID" value="XM_016901707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CX18"/>
    <dbReference type="GeneID" id="27898844"/>
    <dbReference type="HOGENOM" id="CLU_900686_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF08221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="309" mass="34384" checksum="0D7489C925DBE423" modified="2013-05-01" version="1">MNEDGYDNQTEDMLATDLDTFVEKAPPSFVCGVCQIPITATVWQSCRVCDSVDFDVGCVKEGRKLHHRTHPGHGFIQVSSNSDKAEEEEEKQAAVAKLATSLEEEGTSGARRRDSPRAIVSTPRKSTSKPTSQHSRAPERSLLDLSAKDPLTEAIAKGISRSRLQTASSTSEFHTVETFASKWLFTIHCYLRSWSEQNSSPTHAINGFHILVAFDANAQFHGFTRQSYPTEVDGEECFAVLESQEKRNHRFTNPFEAAGAARRLNRRSIEIWKEFRDRAGGDGVIGGWNMGTMGVSNLQEMAKLLEMAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M3CXC8</accession>
    <name>M3CXC8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-lactate dehydratase</fullName>
            <ecNumber evidence="1">4.2.1.130</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_152014</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>methylglyoxal + H2O = (R)-lactate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27754"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="EC" id="4.2.1.130"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase C56 family. HSP31-like subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.130" evidence="1"/>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756442.1">
        <property type="nucleotide sequence ID" value="XM_016907188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CXC8"/>
    <dbReference type="STRING" id="692275.M3CXC8"/>
    <dbReference type="GeneID" id="27904325"/>
    <dbReference type="eggNOG" id="ENOG502RZ3Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070319_2_0_1"/>
    <dbReference type="OMA" id="DPHSLQM"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019172">
        <property type="term" value="F:glyoxalase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03141">
        <property type="entry name" value="GATase1_Hsp31_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050325">
        <property type="entry name" value="Prot/Nucl_acid_deglycase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094:SF11">
        <property type="entry name" value="GLUTATHIONE-INDEPENDENT GLYOXALASE HSP31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094">
        <property type="entry name" value="PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="6">
        <location>
            <begin position="91"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF08321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="230" mass="24368" checksum="C6905ACCE08E53F3" modified="2013-05-01" version="1">MAPRVLFVLTSHDKMGNTGKPTGWYLPEFAHPYYKLEGKAEIVIASPNGGAAPLDPSSVEATKEDAESVKFLKEKEALWTNTQKLSDFVGKADSFDAIFYVGGHGPMFDLATDATSHQIIQEFYESGKVVSAVCHGPAALVNAKLSDGSYLVAGQEVTGFTNTEEDQVQLSSVMPFMLETELGARGGKYVKSSEPWAPKVVASGKGGKLITGQNPASAGPIGEAILAAIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M3CXM3</accession>
    <name>M3CXM3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_121191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756527.1">
        <property type="nucleotide sequence ID" value="XM_016901666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CXM3"/>
    <dbReference type="STRING" id="692275.M3CXM3"/>
    <dbReference type="GeneID" id="27898803"/>
    <dbReference type="eggNOG" id="KOG2084">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_598744_0_0_1"/>
    <dbReference type="OMA" id="EICISYR"/>
    <dbReference type="OrthoDB" id="3640265at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053185">
        <property type="entry name" value="SET_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332:SF4">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="9"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF08406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="457" mass="51232" checksum="E69A341594DDEBFE" modified="2013-05-01" version="1">MGQSSDNAIMYEVRETEFKGQGVFATQNISPGTVIVQESRLMEVAKTGDEYTQHDLEDAFAVLLESERQSVLALSASSRPADEPLLTQIMKSNAFGDGTSTWLHPTICRINHSCIPNATSHHDECCLGDVAQIIAEREICAGEEICISYNSQMHELCTAKERSVLLRNQYGFNCYCPACSPLATKDVTTKQQQHISDTRRRLIAELLHRLTGLHFPPHARQIMQSISTTGDDIMSIPKEDLAAEQGSPSPLSDSQRYVYFLLLAHLRRAEGLESQEISNSYWLAAEALLRQLMTLPDVVILDWAAQIKHLMELAIEVLDRVRDPFDHDPQRLRNEWGNMQKKMRLKASLTFLDSEASSIVPGSADDIPFALRIFPDTKRIEVLSEMECNAIVRQNYAPVSQEDPIPKKAKKPRSDNAYVNFYEDVKSACWNSSKTTKFGAAMTCLAPVLAAYWYAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M3CXT8</accession>
    <name>M3CXT8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_121261</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756602.1">
        <property type="nucleotide sequence ID" value="XM_016901675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CXT8"/>
    <dbReference type="GeneID" id="27898812"/>
    <dbReference type="HOGENOM" id="CLU_1035014_0_0_1"/>
    <dbReference type="OrthoDB" id="10559555at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF08481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="269" mass="30364" checksum="CD92EB1BCC9B4349" modified="2013-05-01" version="1">MLERLPPAVMGLVAEQADNATLLVIGSISTLIRNNSANAFAERYFRSLDVNVPQGSQAQTLALLRQQPVYRTTVSKIIFTDLTGDMHATNQRIYNINSILALVPRVESISIQTARGFRFTDIVFTCLRQTPLAGLRHVHMAGDENHPRPPRARRADVVALLTTHRQTIRTLYLETAMFSSQEWEPILVYIRDHMVLEEFVFSHCEYENEDAEPLITIDPARLPLDLGAGAGYHFHDHVAEMYGVLGIRRGVNRLLHDLGLASYDPHRPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M3CYA3</accession>
    <name>M3CYA3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosylphosphatidylinositol:protein transamidase, GAA1 component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_144505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756787.1">
        <property type="nucleotide sequence ID" value="XM_016903074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CYA3"/>
    <dbReference type="STRING" id="692275.M3CYA3"/>
    <dbReference type="GeneID" id="27900211"/>
    <dbReference type="eggNOG" id="KOG3566">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007442_3_1_1"/>
    <dbReference type="OMA" id="MAIALWM"/>
    <dbReference type="OrthoDB" id="445301at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007246">
        <property type="entry name" value="Gaa1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13304">
        <property type="entry name" value="GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR ATTACHMENT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13304:SF0">
        <property type="entry name" value="GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR ATTACHMENT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04114">
        <property type="entry name" value="Gaa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036762">
        <property type="entry name" value="GAA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="527"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="558"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="611"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF08666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="636" mass="69692" checksum="C9FF9578B03B8748" modified="2013-05-01" version="1">MALAARLLTLRRSPILLKLPPYLSAICILVGITWLLLLPLNEYSRQTYISENAILPGQVHTYFGGSEHNIFRAYRQEVHDLGQRSSAERIEGIERIIKEINLKSATQRYGFEVAGEKIEGTNVYGLLQGPRADATEAMVLIAAWKNFEGEINYSGVALALTMARYFKRWSIWSKDVILLIPEDSTYGPEAWVSAYHSTDIASTTSRNISALPIKAGALQGAVALDYPVGPWGKRFDKLDVLYDGINGALPNLDLINTAVQIASGHMGIGCSLHGLTKHSDKYPDRLRTIASGILSQAQGVATGPHSAFMPYHVDAITLKTVGDGWHDEMSLGRVTESVFRSINNLLEHLHQSFFFYILMNTNRFVSIGSYLPAAMLVAGSFTINALALWILSGRGPVQKPGKLESEGNVKPKGEKLVTIKDGGVVAVVAREEVQSVERRMFLPAVVVVGTHLLSMIPLYLLTHTSKAKLPYAFGIITTSSYILPVYLSILLVRYARTSSQQLQTMQSFSLLFLGATLSTWATLNFSLALTVGLLACPLGFVRPLPLRSSAGISDKQRNLAVALSVPTTLLWLALSPPATLYALSWYLNMDVGGILFEVAKGWVAQGVWSCLVLWSVWWPGWVLAGVVLFSGAVRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M3CZU1</accession>
    <name>M3CZU1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Metallo-hydrolase/oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_19140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758280.1">
        <property type="nucleotide sequence ID" value="XM_016908311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CZU1"/>
    <dbReference type="STRING" id="692275.M3CZU1"/>
    <dbReference type="GeneID" id="27905448"/>
    <dbReference type="eggNOG" id="KOG0814">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030571_6_2_1"/>
    <dbReference type="OMA" id="AGVQRMF"/>
    <dbReference type="OrthoDB" id="449487at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050313">
        <property type="term" value="F:sulfur dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070813">
        <property type="term" value="P:hydrogen sulfide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051682">
        <property type="entry name" value="Mito_Persulfide_Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43084">
        <property type="entry name" value="PERSULFIDE DIOXYGENASE ETHE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43084:SF1">
        <property type="entry name" value="PERSULFIDE DIOXYGENASE ETHE1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF10159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="162" mass="18475" checksum="1FA5BE51DC87591F" modified="2013-05-01" version="1" fragment="single">EPVVHALFEHSTARWQYLIADPTTKDAIIIDPVLDRNPYAPGIDTTAADHLLYLVRQHQYHVVRILETHSVQEHPTSAWYLRTQLRDRHGQMPRICTGKAIAGVQRMFARAYGVQDAGWSARFDSFHDGQVFAVGEMRVQCVHLLSEPDWFGFVIGHNVFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M3D1U4</accession>
    <name>M3D1U4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nitrate/nitrite transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_150398</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759594.1">
        <property type="nucleotide sequence ID" value="XM_016906149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D1U4"/>
    <dbReference type="STRING" id="692275.M3D1U4"/>
    <dbReference type="GeneID" id="27903286"/>
    <dbReference type="eggNOG" id="ENOG502QPIC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024204_1_1_1"/>
    <dbReference type="OMA" id="IPCFMFA"/>
    <dbReference type="OrthoDB" id="434240at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015112">
        <property type="term" value="F:nitrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015113">
        <property type="term" value="F:nitrite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17341">
        <property type="entry name" value="MFS_NRT2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000382">
        <property type="entry name" value="Nitrate transporter CrnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044772">
        <property type="entry name" value="NO3_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004737">
        <property type="entry name" value="NO3_transporter_NarK/NarU-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00886">
        <property type="entry name" value="2A0108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23515">
        <property type="entry name" value="HIGH-AFFINITY NITRATE TRANSPORTER 2.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="475"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="35"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF11473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="504" mass="54907" checksum="6E11406B8B5B97E4" modified="2013-05-01" version="1">MVTLTSLWSAPTINPINKKARTIPVLNPFNQYGRVFFFSWFGFFIAFWSWYAFTPLLSLTIRQNLNLTQTQIANSNIAALTGTLLVRFVAGPLCDRFGPRWTYIIILLSGSIPTAMAGLVNNWQGLIALRFFVGILGGTFVPCQVWSMGFFDKNVVGSSNALIGGWGNAGGGITYFLMPQIYDSLRLDQGLSSDQAWRVAFIVPFILIVSTAAGMWLFCDDTPTGKWSERHIAAEQLRQQIVQIPGTVPSDSSLPGSDNSKHDVKGEKLDMEAHVTAPDVQTGQTLDAAKEEVILAPTLQNTLRILRSPQTLFHCATYACSFGGELAINSYLGAYYQRNFPSLGQTNAGRWAAMFGLLNVVTRPLGGIVADILYKYTHSLWIKKLWIVFVGVVSGAFLIAIGLTDPGSQGMMFGLIAGMAVFLEAGNGANFALVPHVHPHASGVLSGTIGAVGNLGGVVYAIVFRYHGTDYAESFWIIGIMVIGLNLILCWVHPVPRSQRVAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M3D2F6</accession>
    <name>M3D2F6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Potassium transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_163558</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760521.1">
        <property type="nucleotide sequence ID" value="XM_016908068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D2F6"/>
    <dbReference type="STRING" id="692275.M3D2F6"/>
    <dbReference type="GeneID" id="27905205"/>
    <dbReference type="eggNOG" id="ENOG502QPSA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008142_4_0_1"/>
    <dbReference type="OMA" id="IFHGQLY"/>
    <dbReference type="OrthoDB" id="504708at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003855">
        <property type="entry name" value="K+_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053952">
        <property type="entry name" value="K_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053951">
        <property type="entry name" value="K_trans_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00794">
        <property type="entry name" value="kup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30540:SF83">
        <property type="entry name" value="K+ POTASSIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30540">
        <property type="entry name" value="OSMOTIC STRESS POTASSIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02705">
        <property type="entry name" value="K_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22776">
        <property type="entry name" value="K_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="405"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="481"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="515"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="540"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="K+ potassium transporter integral membrane" evidence="11">
        <location>
            <begin position="96"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="K+ potassium transporter C-terminal" evidence="12">
        <location>
            <begin position="611"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="728"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="728"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF12400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="821" mass="91739" checksum="466711DCD6DA6435" modified="2013-05-01" version="1">MSDLINKNIITCVRATFSGCTYTNRLPTGLPLSHPWRILCSSWLPSPSSLWSFCDNACLDIFSVPPPQDHDDEAGIRHDGDVRRKQIFKGRHLFFLAYQSVGVIYGDIGTSPLYVFSSTFTSPPAREDVIGVLSLIIWSLLMMVTLKYVLIILRADNEGEGGTFSCYSLLSRYANITNRDPREEPMIKMERYLTNEMRPANRQVRKTIESSAFFKTLLKVMGVFAVSMVMSDGVLTPAQSVLGAVQGLNVIVPDISQGTVIGATCGILVMLFVVQPFGTSKLGSVFAPIIIIWLGLLASFGIYNLVMFDAGVFKAFNPGEAFDYLIRHGEDGWRSLGGVLLAFTGVEALFADLGAFSMRAIQISWLCWCLPCLLLTYIGQAAYLAVRPEAYAYPVFNTAPPGCLILSMVLAILAAIVASQAIITATFQLLAQIVKLSYFPQIQVVHTSKTYHNQLYVPLVNYLLCIGTVAITAVFRDTTSLGQAYGVCVMFVTFFDTQMTALTALLVWRLRPWMVVLPWLAISAMDGAFLSSALTKVPDGAWFTITLAAILACIFILWRFGKEQQWRAERHDRNPLSHYVRKDDEGSLRLTNFADTLLEQPWGEKLSVTKGFGIFFDKGGDKTPMIFSQFINKLVSKPEVTVFFHLRPLETPTIDISERYVVRQLDSLPNCYRVVARYGYMDEVVTPDLATLIYHRVSDHIILQQQNRKNHEESASDNDHISHRIITTTEKSSATATSSTTTTTPPLGGISSNLHNLQTAFEHRVLYILGKEEIHIQPQTPLWRLALLKVFLFVRENSRNKMANLKVPTDRLVEIGFVMDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M3D3I5</accession>
    <name>M3D3I5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6594 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_12493</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760580.1">
        <property type="nucleotide sequence ID" value="XM_016901941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D3I5"/>
    <dbReference type="STRING" id="692275.M3D3I5"/>
    <dbReference type="GeneID" id="27899078"/>
    <dbReference type="eggNOG" id="ENOG502SQVM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_923063_0_0_1"/>
    <dbReference type="OMA" id="DSKEPRM"/>
    <dbReference type="OrthoDB" id="5416037at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046529">
        <property type="entry name" value="DUF6594"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502:SF6">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20237">
        <property type="entry name" value="DUF6594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6594" evidence="3">
        <location>
            <begin position="35"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF12459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="302" mass="33901" checksum="83F61F5C74F2EE63" modified="2013-05-01" version="1" fragment="single">AYSASYYSPQGQVAHSAPPQVPDAPNNMQRTVVGYELLARELSSPDSPVQPLYRRFEYLHHRILLHMQDELQEMEEQLRRVDEIIATMEPPPEEGQPPTPSSRRGDKNFGTPWHHQRTELLGRIFLKTKDYNAAIASFASMTKHSATAEQNHIEHYRDWLTQKSPIHELETRFLATENEKDLISPILDSAPPLPQPIQQQQQPLSTPVLQPIRKHPPPPHPTPPPPQNLAAILSLSFLPILLFSMIPTFAGRFFVTLLIITGTGFVAAKTRFGDVMPLGEWVVCAAVYVLVSMGIAGCVPVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M3D3T5</accession>
    <name>M3D3T5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_149197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016905403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D3T5"/>
    <dbReference type="STRING" id="692275.M3D3T5"/>
    <dbReference type="GeneID" id="27902540"/>
    <dbReference type="eggNOG" id="ENOG502RV52">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_797320_0_0_1"/>
    <dbReference type="OrthoDB" id="3650863at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004033071" evidence="1">
        <location>
            <begin position="17"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF12564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="348" mass="34297" checksum="CEB72C78B34DCCE5" modified="2013-05-01" version="1">MYSAAVVAAIVGSAAAQASYGAPASACPAAGDKAADGRYSCNPAHSYPDGQTCQASDGCYYLVNQGPGVTASASSSASVYVDVPEYRTASASASASNYVDVPEYRTATSSAPSAAASCPATGSAGPDGRYSCNPAHSYPDGQTCQADNGCYYLVNQGPGVYASASSSASVYVDVPEYRTATSSAPAAAASCPATGSAGPDGRYSCNPAHSYPGGQTCQADNGCYYLVNQGPGVYASASTSASVYVDVPVYRTATVSAITTYCPQPTTFVHSASTYVVTAATTLTMACPGGCVVTESATAPAGYMPTGGLIPGAPKNGTGNSPVAYTGGAAFATGGPLAVLAALGALFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M3D418</accession>
    <name>M3D418_SPHMS</name>
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        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_86379</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016910413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D418"/>
    <dbReference type="STRING" id="692275.M3D418"/>
    <dbReference type="GeneID" id="27907550"/>
    <dbReference type="eggNOG" id="KOG2093">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054245_0_0_1"/>
    <dbReference type="OMA" id="HYVSVEW"/>
    <dbReference type="OrthoDB" id="427711at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017125">
        <property type="term" value="F:deoxycytidyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
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    </dbReference>
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        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
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    </dbReference>
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        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="118"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF12925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="237" mass="25509" checksum="6F07D6ECE719EF98" modified="2013-05-01" version="1" fragment="single">MPYKAQMAAKPSKQIFDPFNSSATGHQRADNRLGGSTSWRDSRSLKLREQFSGGSGGGKRMNDTVGAGSLDFGQDGRTENGGWEKGAKGLRTAGQQSIWESMKSETRFHEDDEPKPPPPPQIFANLTIYLNGCTAPLSDHKLKHLISTHGGNMSISLGRRTVTHVILGKINANGGCGGGLAGTKIQKEIASLRAKSVKFVTAEWIVDSIKAGKRLPESRYEAMKLAPKGVANISTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>M3D4A3</accession>
    <name>M3D4A3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ras GEF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_126073</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EMF13030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016902034.1"/>
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    <dbReference type="eggNOG" id="KOG3417">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001471_0_0_1"/>
    <dbReference type="OMA" id="ICNYATM"/>
    <dbReference type="OrthoDB" id="10254377at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
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        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
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        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF363">
        <property type="entry name" value="PROTEIN SON OF SEVENLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="5">
        <location>
            <begin position="348"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="1439"/>
            <end position="1689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="164"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="540"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="594"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="671"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="788"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1108"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1219"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1350"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="182"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="297"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="548"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="614"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="721"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="750"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="803"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="828"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="856"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1121"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1225"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1254"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1350"/>
            <end position="1363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1382"/>
            <end position="1400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF13030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1689" mass="186288" checksum="68F3BDCAC255DDC2" modified="2013-05-01" version="1">MMEKGTIARRRQKDTAQFGRPPTRLRHHNRTQSDVPSQPDSPRSPIAIRRNEDGFFEGINKGHKRNDTAPTTKSSVYEENPKNFTVVNVGAGGVLYLKPSRVPVPNPNYAPATPPATSDGAESYYTRYTDQGEQPLLRESTASLYSGTRTPRFSRSNTTANVQSYLPSCSLPNRHHRRRTRSASCSSMGSRVNSLQAVHEEDVSRSTKAPKFRRRSSADTERGELGVRIPHYRLGTPRFSDRGTAYLHSSIHTNSSVPSSVLSQAEFEKIFPIPPGRGISFLAAQSNRQLRVPSTARAPSNDTRSRSLATRSAFSSNRPSTLGFITPDTFDKIEDNLDNPAFVHYHPATGRIVAATPARLIAQITSPDFLDYELLADFFLTFRCFMQSEELLDYLFARLRWALTSGNDGGRIARVRTFVALRHWILNYFADDFLDDAMFRQIFCDFVNDLAAVLRERPDRGGGDMNIISELKKCWRRTCMLYWPATEPMDTPPDADIFPGGIRHQDVSPAAASALSLPLSIRPTTYRGSIFEITTIQLPERPPPRHLTLTSGNEPGQRSTTTTTRTASIPASPLSEQSLEVLSCSVPFLRHIRPTARAREKQEPRIAGAPPKAGKPRPKVHKRSGSFSDALRDRRTPLASAKTDNIELKDLTSFAVTGGLVRGLLLQPSPSKVENTVPVTPGPELNEGQFSGNESDNERNHNLGVRKFVVEVRRALGNRKPSNSRSPARSLSSKGSLGSRDGREAHRPQQKPSPDWQQLQGPARLDVLGLAIERSYQGARDDFARTEVEPIQEHPSAELQTEEADRSETPRPATAKRDEPPPSAQGYASSGLPSSGALPSSGLPSNGLASGQSKSSGERDISRPDTHVTSGSRSIVIVDATGAPELPMMSGALPSLHNTTPEMVPIPLFRNRADFNLVRRPSIGQAIAEPPRTVAGEAEFHWRSSDARMHDLLTSSDRWSAEENSRAGNSAMYAESNVLRRSSVFAPNFELQAVPHQLRRVPGGNLRDANHVRSLEMAQPRPRSEGSLMSTAMSRVLTVTSKRTTEEGGVPLSGFDELSRNSVVLLATHSSQPVLRPSFEEEARKLKGIPDKDSDGAGGIEDALLKLEGKIPSPSIGSSADSRKSSESSESAHSHASTTQPTSIDGSRSPLPAPPMLREMPTGYARPVYGDIPMKISPSIQSSHPNVASPVTETQGASIFHPSVSAVGFPFAHEPERVEEAGRDVPTTVSSPSASVPPMAARLSQWPITDPYTAASTPESSAYAQSQTSVHSQSEFRLPSGDSATIPSFKPGPWGNQTSFLHDEHQSFSDISTEIVDYESQNGHTVRSFFFDDTNHDGHVSMRPFQLMSATPPSTIAEPTSFESPDRRQLLPRAVPPRPGQTLKQKISNPKLQEMASNQPFPRRSGDAPKRLQPSPSPSNESSVNVSFEEHIPFVLAYESEVIAEQLTIIEKDALDEVDWKDLVSLNWQQSPPNIRNWVDYLNTESSNGIDIVIARFNLVVKWCISEIVLTEAPSERARAITKYIHIAAHCHRLRNYASLYQITLALLSNEISGLTMTWSLVALREKHMLEQLEQLCRPLRNFHNLRAEMETAMPGNGIIPFIGLYTHDLMFNALKSARIDPPPPGKESLVNFERYQTAANIVKNLLRLIEASSKYTFHPEPEALSRCLWIAALEDSEIQSRSMHLEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>M3D4F8</accession>
    <name>M3D4F8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_117328</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760890.1">
        <property type="nucleotide sequence ID" value="XM_016901326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D4F8"/>
    <dbReference type="GeneID" id="27898463"/>
    <dbReference type="HOGENOM" id="CLU_2198647_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF12769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="108" mass="12504" checksum="613D1C96136081C9" modified="2013-05-01" version="1">MASYFEVNMQMRRNRWAIVAKRTNNIFGLMRPGVVVNPLLASCPNHAILLRTVISDDIWDTWQGSAAVIARELKLTERYSIRTIPRDGEVHHYPRVSFLAEADMYENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M3D505</accession>
    <name>M3D505_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_149480</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761075.1">
        <property type="nucleotide sequence ID" value="XM_016905579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D505"/>
    <dbReference type="STRING" id="692275.M3D505"/>
    <dbReference type="GeneID" id="27902716"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_25_2_1"/>
    <dbReference type="OMA" id="NPKYWPA"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11070">
        <property type="entry name" value="CYP56-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032824" evidence="7">
        <location>
            <begin position="27"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="543"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF12954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="634" mass="71721" checksum="C5D894AF4521B73D" modified="2013-05-01" version="1">MGPSYLGLALLGLLALYAVNTYRALAKNISAAKQSGIPYVVLPVYTFNRFWLVTHRLWLPFIDAVPALRNATWRQYVVPEFAWAKQYDSFKEMGSDMFMLVSPGANTLFVADPEATTQIATRRADFPKPIWMYTSVDLFGKSVVSTEGHTWRHHRKVTSPPFTERNNHLVWQESLRQAQGMMAGWIRTDQKDSGPVWNVATESMRLSLHVISLAGFGVQLHWPHEGKVATVPEGHTLTYKDALEVLLHNLITIIITPRWLLPRSPLKIHKTANEAYVEWGQYMREMYQAKRQQVRAGEGQGDTGNMDLMGALVKGAGLTQETLNVDVNVDTEKAQAKAGQLPFTDEDIMGNSFVFILAGHETAANTIHFSILFLAMHMASQRRLQKDLDSILGNRPSSEWDYENDMAKLFGSMCGAVMNEQLRLIPPVIGIPKVTPKDRPQTLHIDGKQITVPENTYVTLNTAASHRNPRYWPHTSAEDLLEFRPERWLLDPSKTTPGQHEDEEYAAEEGLEFETDKRPDTAASLFRPAKGAYLPFSEGYRSCLGRRFAQVEILAVLAVIFQTWTVELDVSEYLSDEQFARASEAEKRAAWTKADARARDLLKNGMMTIITIQMRTGKVPFRFVKRGSERFAFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M3D545</accession>
    <name>M3D545_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pinin/SDK/MemA protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_132641</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pinin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761431.1">
        <property type="nucleotide sequence ID" value="XM_016902505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D545"/>
    <dbReference type="STRING" id="692275.M3D545"/>
    <dbReference type="GeneID" id="27899642"/>
    <dbReference type="eggNOG" id="KOG3756">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_654109_0_0_1"/>
    <dbReference type="OMA" id="ALYYKPW"/>
    <dbReference type="OrthoDB" id="330772at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039853">
        <property type="entry name" value="Pinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006786">
        <property type="entry name" value="Pinin_SDK_MemA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12707:SF0">
        <property type="entry name" value="PININ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12707">
        <property type="entry name" value="PINN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04696">
        <property type="entry name" value="Pinin_SDK_memA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Pinin/SDK/MemA protein" evidence="9">
        <location>
            <begin position="113"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="13"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="260"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="132"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="304"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="356"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF13310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="420" mass="46594" checksum="DCB05DC59835B961" modified="2013-05-01" version="1">MAEVIASAVALPDSEDVVKRATSNGMKRRQSDVADDIDGSSKRQRTSPGKTSPRSRSRSAAKEGGEVASSAARARSTSPTESKNGSASKPETSAEKDREGGGRRKNTVVKAPDEKQRSKRLFGALLGNLNRPSDRTSKRRAEIEQRKKAELQKQDDERLEDRQRRLERLAIQRKNEQLEVDERDMHIRHKHMLSTANFLQTKATPKLYYRPWDLLDDEEDLIERQLKEAQAQIDRELIEWETEKCRRLGITKDLLNMAPSTSAPCQARQDTNDKVGNSTSPHEAFEDAAIAKSGSNKDEEMAAKNTNIQPEQESTTNDEISDRPVEGPECLAASPHNPNSVVDGGAAKQVSTSGEVETKESEKQRKTEVNNGTSVDREETETTPSCGTRAALDGDAKDEKDELDDDGDHVVKGDEDDVIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M3D5C3</accession>
    <name>M3D5C3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_63669</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761205.1">
        <property type="nucleotide sequence ID" value="XM_016909647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D5C3"/>
    <dbReference type="GeneID" id="27906784"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006937_6_1_1"/>
    <dbReference type="OMA" id="DPCSSWF"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF7">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF13084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="604" mass="69551" checksum="5B9DFFF1152A7F6A" modified="2013-05-01" version="1">MGHVGDVRELPLHLERNNPTAERDGHLIPEVDDTGYRIREQPYGTKREVKVILMGAGASTLNFLKKAEEQMSHLTITVYEKNHDVGGTWLENRYPGCACDIPSVNYQFSWAIKIWSQFYSSSTEIWEYLKDLYTRGNFIDKYVKLNHQINHAEWNEERGKWVIKAKNLKTGEEIDDEAEFFINAGGVLNNFKWPDIPGLKDFKGKLMHSAAYDEGYDLKGKKVAVVGAGSSGVQIVAKIQPDVEHLYHWIRSPIWITAGFAQTWAGKDGANFEYTPEQLQYLQKNPHKYLEYRKQIENELNQRFKFIIKGSQEAAEAREFSYEQMARKLNHDARLCDKIIPKNFNPGCRRPTPAPGYLEALISPNATIFTDPINTFTETGFIDHNGTPHTCDVVICATGFDTTWLPRFPFRGKHGQDLRDIWTPEAGVTSYLSIAIPHFPNHFTFCGPYGPLGHGSFMPLIERWTAYMFDMIRKAQIENLKSFTPKEDVARQFRRHADLFLQRTAWTSGCRSWFKQGKEMGQAAIWPGSRLHFLHLLERPRYEDWEIGRWDENVFAFLGNGFDTREFDGRDITNYLGLLEEGKDEQPQYGEELLNKLAGWAIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M3D6D2</accession>
    <name>M3D6D2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_116454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761535.1">
        <property type="nucleotide sequence ID" value="XM_016901259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D6D2"/>
    <dbReference type="GeneID" id="27898396"/>
    <dbReference type="eggNOG" id="ENOG502QZR9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_480727_0_0_1"/>
    <dbReference type="OrthoDB" id="3638124at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF13414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="567" mass="63366" checksum="C2DE70A2BA38573D" modified="2013-05-01" version="1">MATRWHFAGDDALPYAFGAIGEEVKAARGDFNFSDNYGASSVFENSPTSSDDTDSLRKLVEGSKPLNKESPRAALYQAQFKTNEPSADDIELQKEEAAVATLLEAVAGFNMDGYDYPCDESSVDSTIPTMEHSPIQAPGYPDSEDSDSPTPHSRPIRLADIEFPTPQRQPVSLAEYKRSPPGAATRHVSHSVSHLGYPFLPSPVQEDPRGQSAELTAEPDHTNDKIVHSQDPVYWFNHEALSSLEPRDLLSILYAATSGATSGATSGATSSNSSRSDQKTYLELFNDVNDKIELICRSYVSINAPGDPEERRKFKHLASSHVNYKGVAQYIMQTAHLQSAFVVGLIWRLVFDSIFDTPVLDQAPSPYAQAFLKAWIEDFHGDPTRSQMEWAEYKRPRMEARTAAARNVIEQTHGFTEWVEYFAATKTMAIVDQLAFAWRQGTKKTVSVELCVPILKLVRIAIRMRSELRHFGFTFLQYGLKARSDIYVQHSEYGSEAPPPPSDDENQHVVFTKVPGIYERDFGEVRLAQTDLYKLEVVVRKNWPGKGHMHKKFTGALVNSHPEGLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M3D7K6</accession>
    <name>M3D7K6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peroxisomal-coenzyme A synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_40463</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762291.1">
        <property type="nucleotide sequence ID" value="XM_016908785.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.M3D7K6"/>
    <dbReference type="GeneID" id="27905922"/>
    <dbReference type="eggNOG" id="KOG1176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003997_0_0_1"/>
    <dbReference type="OMA" id="HTRWWLT"/>
    <dbReference type="OrthoDB" id="3633556at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF10">
        <property type="entry name" value="CARRIER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="926"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1113"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1165"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1452"/>
            <end position="1480"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="773"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1359"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1367"/>
            <end position="1376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF14170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1665" mass="181177" checksum="CAD5EA53D0DD51A1" modified="2013-05-01" version="1">MATFLFDSSIVDQEELPLYRQFLDDAVNSPFDHQTLLSKIPRPTQPSYGPLATLSALIDTKSGPWPVTGIQRAHTALWKLLPEEAKAGHGPPAIRALLEHVSQQCKSTYSSLLDLYHPGSTAAAILDPDTGRSIQHNDLASTISTFRLPIAHSPGGPKPVIAISLPNGPLLAMTVLATATYYTAAPVAHGSGVGAEQFKADVLQSKSNAVLATSADVARLGLRDSWLADAGILVLLVDLDQDMRLRIADLDGRDIIQEHTSLPPVRNTADDTGIMLFTSGTSGTKKLVPLSIHSMVCGVAMVEQSWGLSPTMRCLNQMPLNHVGGLIRNLFAPVFSGGSVICCSAFDPGLFWDCVEDFSPTWYYASPTMHQMILEAGRERPESVAKSQIRLICNAAGGLLPSLALQLRGTFSTSTVNCIVLPSYGMTECMPISTPPLDYQLDRTGTSGVTVGPEICILNGRDTPEATGEVGRICVRGSPVFGGYLKGDNVIDKTCFNANGWFDTGDMGYLDSDGYLFITGRSKEVINRGGELISPFEVEEAVVGAASKPGSPTYGRITKALAFSVNHDVLQEVVGIAVATTEGALRPCLRTIQESVKNVLGQVKVPVAVVYMDGGVPTNNNKVLRIKLADRLGLPTISDSTAPAGRHFEAVCPPPNTALSVSIACRPLAVSHDKLANACKIEVPASFEYWIKHSDFYAELVLAPKAAGENGAVNKDSLTNSIAARVDGYSIPVKIHQLEEPFFRDTRGNIDEAAVAAKLTRPRPTVAASAPAAPSMSTEDTVSRIFAQVLSLSIEEVSSSSDFFELGGDSMGAGRLLTMLRKEYPLRLPINTLFTNPKVSQLARIIDEKMPKNAVPKEENIVTREPEHLPGCEETYSSSNVALMLLQLVPMGIFYPMKRALTWTIFMYMLTETSHWITSKYLPGRLFGLVLSITIGSIITRIIAPLVAICFKWLVIGKYRQGLYPMWGSYHTRWWLVQKTTAVAGMGVFGLFNWSRVLYLRLLGAQVGKNVTVQKGVIAGEWDLITIEDNVILERSIIRPFAAERNTSMYLGKIHIGANASIGLASIVAAGTSVPAGACMGPNSSSWETEAFDEANRDLASSRIKGTHWTLEYILGLPLGFICTFCGAVPWLACLLALVKRKPTPSPDMFHSTILWFASKNRVGYHYLALAANVALGPMFFFAAVLAFKKMFDLCLGKVKPTSEERSQIDKFRMGWIRMVMPSARFHKLTELFGTHYNATSHFARAMGAKVGNRVYWPGTGPSIQDFDLLDIGDDVVFGSRSHLVTSDGSGSDYVRIKARAMVADRVVLLPGVELGEQTVMGSGALTKRNTRYADATTWVGAKKGEAICLTADASSATPPKLETPFNDKQSPFSNTSEEESTPFGRAFYEGKASYRVWSQFEIYLYSTAISVINGVYWNVGSVSAVQVVARLYEEHNSVALNFLGKTSYRPIAIYVFFLALIMGIMALQSIIVIAATIAAKWILMGRRKPGNYDWDKSSYCQRWQLFLKLETFRRHCYGSQGILGLLTGTQWITMYFRALGADIGKDCALFAGGLPSLMFTEPDLITLGDRVALDDCSVVGHINTRGRFDLNPLSIGARSVLRSGSRLLSGARMEEDSCLLEHTLIMAGDVVEGGTTSQGWPADDFTASRMPTMETARHWQVKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2022-12-14" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>M3D876</accession>
    <name>M3D876_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_131816</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762195.1">
        <property type="nucleotide sequence ID" value="XM_016902452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D876"/>
    <dbReference type="GeneID" id="27899589"/>
    <dbReference type="HOGENOM" id="CLU_1661885_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF14074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="159" mass="17289" checksum="193A6EC86DA02465" modified="2013-05-01" version="1">MTTTTMTTTTTTTTLTCAREDSGSALIPKLAHKSVHPEAREENPTWPERPPRIGFAQLLPPLIIAWISNCNKTGVDILPTAIARITQALVLVGLLSMCAEGNPASWSGRTPKRLPVFSFLIETICVLLVIDLLRLDPDEAHELVSTAGWRDGSADLFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M3D893</accession>
    <name>M3D893_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_62144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762215.1">
        <property type="nucleotide sequence ID" value="XM_016909587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D893"/>
    <dbReference type="GeneID" id="27906724"/>
    <dbReference type="eggNOG" id="ENOG502R2IM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_918805_0_0_1"/>
    <dbReference type="OrthoDB" id="3649358at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF14094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="303" mass="34408" checksum="D6E092FE21645FAA" modified="2013-05-01" version="1">MPGLVAPDAPASPVHALTARGQGRADMSTRTTAFYGGNPFLYEPDRQGRRHWRLDRQKPPGDAYDDHPLVPAHWSVSPAMTQVDDAYRYDTRCDRLSQWTPKMHTVNELADEVLRAHGVPDVGRRGLYICGHMADVVYSPDANGKDRNSDRERIMVFVIELSRADRHKWRDMHEELVEVLVRAGVRDYHGVPIRYFELRTSISLTAEPEPLDGLEQDPAEESVESPTSPMSSAAMPAWATSAPPVRPAPRSLQTFAEAHEYVMGRSREYMQHRSQEQERNVGSGNAFFSRDPRLQDPRLRRNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M3D8H8</accession>
    <name>M3D8H8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_115697</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762541.1">
        <property type="nucleotide sequence ID" value="XM_016901191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D8H8"/>
    <dbReference type="GeneID" id="27898328"/>
    <dbReference type="HOGENOM" id="CLU_2442273_0_0_1"/>
    <dbReference type="OrthoDB" id="5202228at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF14420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="90" mass="10623" checksum="717322B6112DAB68" modified="2013-05-01" version="1">MCTRVMHVYQCGCREKGELKQCNRLYEQESNLQCNVTDVDPKISRNYCSKHMPKENKATMAYAWRILTVLVAQWYADCQEDVDVDGFQYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M3D948</accession>
    <name>M3D948_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">D-isomer-specific 2-hydroxyacid dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_115942</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762796.1">
        <property type="nucleotide sequence ID" value="XM_016901207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D948"/>
    <dbReference type="STRING" id="692275.M3D948"/>
    <dbReference type="GeneID" id="27898344"/>
    <dbReference type="eggNOG" id="KOG0068">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_1_3_1"/>
    <dbReference type="OMA" id="TGTQFET"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050857">
        <property type="entry name" value="D-2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="6">
        <location>
            <begin position="12"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="7">
        <location>
            <begin position="190"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="110"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="162"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF14675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="389" mass="42981" checksum="504F37CB2DFDF6E4" modified="2013-05-01" version="1">MSASQTVKRVAVLDDYAQISPKHVDPIKDIKVSYWDQTLNPTKEDDLQALIRRLEPYEIISSMRERTAFPASLLSQLPNLKLLLTTGMRNNGIDLPAATQYGIIVTGAKGERVSGHGDDDDDDDKYKTYEAPPPTGHTTVIQHSWALLLSLMSRIVEHHNLLQQQQQQQQQQQQQQDSSSTRSSSPAAAAWQQGTIMTLPGKKLGLVGLGKLGVAFGKIALQSFGMEVLAWSTNLTQERADEQAVAAGLEKGSFQAVGKEELFGGADVVSLHVVLSERTRGVVGKKELEMMKKRAVLLNTSRGGLIDEHALIETLTAGSIAGFASDVFWEEPLGPESVWRRVGEWSKSSTVFSPHMAYVNEGTMNRWYEEQAEIIHQYLKGESLSNRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M3DBV2</accession>
    <name>M3DBV2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_105786</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763661.1">
        <property type="nucleotide sequence ID" value="XM_016900591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DBV2"/>
    <dbReference type="STRING" id="692275.M3DBV2"/>
    <dbReference type="GeneID" id="27897728"/>
    <dbReference type="eggNOG" id="ENOG502RHRN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_924916_0_0_1"/>
    <dbReference type="OrthoDB" id="4748970at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="78"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF15540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="301" mass="33781" checksum="07F4568E313D0406" modified="2013-05-01" version="1">MATRAPIPEPVALNPQHPATSGRSDLDTPSPTSCQRRDPYHPKKKFSCTWPGCTHAQFTCPHNVAQHIREQHTYDRPFKCTYCAASGTVKAFARQGTLNRHERDIHKVHRNIHHGRGRKPTVGFKFEPQVVRPKFKGFGDAGRQGSSHRYSPRISPAQSNIMAWQFPVEPSSSPSPMAMADEQLPETGRHSLFHLSPQQPPHRPVTYTTTNSSTFQLGPNVTPPIGSTKQPIDTFRTIPGATYPTDDTDSTFDEIWASLEQTSRSLSPCRHLPVDIQQPTVRFSLDQVEAGNDEFATWWNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M3DCU2</accession>
    <name>M3DCU2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Brefeldin A esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_154401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763750.1">
        <property type="nucleotide sequence ID" value="XM_016907560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DCU2"/>
    <dbReference type="STRING" id="692275.M3DCU2"/>
    <dbReference type="ESTHER" id="sphms-m3dcu2">
        <property type="family name" value="Hormone-sensitive_lipase_like"/>
    </dbReference>
    <dbReference type="GeneID" id="27904697"/>
    <dbReference type="eggNOG" id="KOG1515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_787138_0_0_1"/>
    <dbReference type="OMA" id="GLQYYRR"/>
    <dbReference type="OrthoDB" id="433474at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050466">
        <property type="entry name" value="Carboxylest/Gibb_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024:SF24">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024">
        <property type="entry name" value="ARYLACETAMIDE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="1">
        <location>
            <begin position="133"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF15629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="382" mass="42215" checksum="05BC76ECC33C459A" modified="2013-05-01" version="1">MASESSPPEGTDPVAALCTRPGRLGDWNMKLFQDPRAHPKLVEVFRAFGMDGSQGNPFEGASVQDLASTTQMAKNHASTMKLYEILPNDLVGDQQEQSQIHRETLTFPSFDGTERQMFVFRPAEQSRRVLPVVVYFHGGGMVLTSTSNKVHDRWCQSLAVQGVMAISVDFRNAYDNGKHNAFPIGLNDCAAAVQYIYQHKAELQISNIILQGESGGANLSLATALKAKREGWIHQIAGVYGIVPYISGAYGWPDARKLKELPSLYECEGYWLYTSMMAGMASYYCGEGEEGEKAKETPLAWPYFASIDDCKGLPPHVLAMDELDPLRDEGMAYYRKLLAAGVEAHAKVNLGVVHATSLVFRKLLPEFHNNAIRDVTSFAKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M3DCZ5</accession>
    <name>M3DCZ5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase family 12 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_131321</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 12 (cellulase H) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763810.1">
        <property type="nucleotide sequence ID" value="XM_016902411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DCZ5"/>
    <dbReference type="STRING" id="692275.M3DCZ5"/>
    <dbReference type="GeneID" id="27899548"/>
    <dbReference type="eggNOG" id="ENOG502RXZE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051064_0_1_1"/>
    <dbReference type="OMA" id="NLWGQAQ"/>
    <dbReference type="OrthoDB" id="95118at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002594">
        <property type="entry name" value="GH12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002">
        <property type="entry name" value="BLR1656 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002:SF9">
        <property type="entry name" value="XYLOGLUCAN-SPECIFIC ENDO-BETA-1,4-GLUCANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01670">
        <property type="entry name" value="Glyco_hydro_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032934" evidence="3">
        <location>
            <begin position="18"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF15689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="253" mass="26746" checksum="2CF5FB3908F161A0" modified="2013-05-01" version="1">MKAATIFTAAFASLAAAGPTKDTKRADNCEQWGSVVKGDYTVYNNLWNKNAASSGSQCFSVGSLSSGTIAWSTTWSWSGGSGQVKSYPNAVYNPGTKSGKQISKISSMPSVWQWSYSGSGLIADVAYDIFTSSSATGSEEFEIMIWLAALGGAGPISSTYGANGKPTPVGSITIGGVAFDLYKGPNGSMTVFSFVARQQVKSFNADIKQFFQYLVKAQGYKDSQYLISAGAGTEPFEGTNAVFTTTKYSFSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M3DER7</accession>
    <name>M3DER7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_61466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF16009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764130.1">
        <property type="nucleotide sequence ID" value="XM_016909563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DER7"/>
    <dbReference type="STRING" id="692275.M3DER7"/>
    <dbReference type="GeneID" id="27906700"/>
    <dbReference type="eggNOG" id="ENOG502QSKG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010595_1_2_1"/>
    <dbReference type="OMA" id="ENERRYH"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF16009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="388" mass="43809" checksum="FA684A240B9180EC" modified="2013-05-01" version="1">MAGDEALVDVEQLKRDIDSQNTTSNYNWKFENGRRYASSELGHYYMPNDEPEIQRLNEQHWILTQVKGGSLHFAPLPPATEKASPKILDVGCGSGIWCVEMAEEYPSAMIIGMDISPIQPVQKPANVEWITLDMESSSSSSSETPWPFPENYFDLIHLSLVHGCISNWPTFTSKLTHHLAPGGWLEHQEFSLCKQYMLDTHTNLPLPMPPNPSDLLPFFRWNKLMEQAGLARGRPLQLGPQLTSFQRAAGLENIQERVFAHKWGTWMEDERERALGARTMVNTISGMEGFTTVLFTKTLGWSLEDTRGFIKEIKRDMRDDGIRKVVDLHVVWGQKRKDGGGIEKVLPRGRNGGNGWGGKVEQYASLGTGVVLGAVVTSLVSWWLMRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDL0</accession>
    <name>N1QDL0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Charged multivesicular body protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_151523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757667.1">
        <property type="nucleotide sequence ID" value="XM_016906871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QDL0"/>
    <dbReference type="STRING" id="692275.N1QDL0"/>
    <dbReference type="GeneID" id="27904008"/>
    <dbReference type="eggNOG" id="KOG3229">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069208_0_2_1"/>
    <dbReference type="OMA" id="KILWEVT"/>
    <dbReference type="OrthoDB" id="2329734at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904669">
        <property type="term" value="P:ATP export"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070676">
        <property type="term" value="P:intralumenal vesicle formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="227" mass="25423" checksum="3E4B44F81A11C110" modified="2013-06-26" version="1">MDAARRFFYGPSPEEQKRKCNSLLRSNTRKLDRDLQNLKALESKTKSLILQASKRAQKNPSQAKQASAETRIFARELIRVRRQTQRLATSKATLQSVGMQVNEAFAMKKIEGGIRNSVGIMKDVNMLVKLPELTGTMRELSQELVKAGIIEEMVGDSLPDQELLEGEDEEAEAEVDKILGEVLKDKTAAPQLPSEPLGPVEAQPEEDDFESEETLAQMRNRLEALKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDP2</accession>
    <name>N1QDP2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL23m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_151575</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757741.1">
        <property type="nucleotide sequence ID" value="XM_016906902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QDP2"/>
    <dbReference type="STRING" id="692275.N1QDP2"/>
    <dbReference type="GeneID" id="27904039"/>
    <dbReference type="eggNOG" id="KOG4089">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086423_2_0_1"/>
    <dbReference type="OMA" id="LPPNEAC"/>
    <dbReference type="OrthoDB" id="275582at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_uL23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12059:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL23M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12059">
        <property type="entry name" value="RIBOSOMAL PROTEIN L23-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF09620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="179" mass="21131" checksum="9E1EF1DC675E845C" modified="2013-06-26" version="1">MALASFKVGTKELFIPDVNIALLRTPGLPANNAKFNVPLWFSKLDLRDYLFHVYNVEVVSVRSYVKQSRVSPGRPGMDRPSMSRWHRPRPTKFMTVELVRPFVWPEEPEDGYKDWNRKELADSDEWQKEINEHHGTLKDTIVNKERRERMREQAKALLEGKAKWKAPEAKILQDFRREQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDT1</accession>
    <name>N1QDT1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MFS maltose permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_151642</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757847.1">
        <property type="nucleotide sequence ID" value="XM_016906948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QDT1"/>
    <dbReference type="GeneID" id="27904085"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_11_5_1"/>
    <dbReference type="OMA" id="RDDEWAY"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000149">
        <property type="entry name" value="MFS transporter, SP family, general alpha glucoside:H+ symporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF56">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="413"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="458"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="482"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="62"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF09726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="564" mass="62778" checksum="18E43201139EA508" modified="2013-06-26" version="1">MADQKEIQAEKAEGPLHFSHGDDLNMTTSMKQTVLDAKKASDEEQKMSLLQGIKLYPKAIAWSILISTCIAMEGYQVALVNNFYGFEPFNRKYGEPTGDPDSPYQVSAPWQAGLSNGALVGQFIGLFINGWASEKFGYRKTVITCLTLIIIYITIFFTAPNIQTLLVGEILCGMPWGVFQTLTITYASEVCPIALRGYLTTYVNCCWGLGQLIAIGVIRSMFTRTDQWAYRIPYALQWMWPVPLVIGVAFAPESPWWLVRKGRMADAKKALIRLTSTNRETDFNADETIAMMAHTTALEEQTTSGASYLDCFKGSDLRRTEIVCMCWAIQNLAGNSFSNYSTYFLQQAGVSSKNSYNFAMGQYAINMVGVFGAWGLMSLGVGRRTLYLYGLVALTTLLLIMGFMGLVDDRETAGLATGSIMIVWALVYQLTVGTVCYSLVAEVSSRRLQIKTVVLGRNLYIVAAIICSTITPYMINPTAWDWGSYAGFFWAGLAFLCCVYTYFRVPEPRGRTFAEMDLLFERRVSARKFASTEVDVFGETLDESVVSQYKDGLAAEHSEMTKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDZ1</accession>
    <name>N1QDZ1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Terpenoid cyclases/Protein prenyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_27701</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758566.1">
        <property type="nucleotide sequence ID" value="XM_016908432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QDZ1"/>
    <dbReference type="STRING" id="692275.N1QDZ1"/>
    <dbReference type="GeneID" id="27905569"/>
    <dbReference type="eggNOG" id="KOG0365">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028946_1_0_1"/>
    <dbReference type="OMA" id="WCIYWIL"/>
    <dbReference type="OrthoDB" id="10261146at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005965">
        <property type="term" value="C:protein farnesyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004660">
        <property type="term" value="F:protein farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000014">
        <property type="entry name" value="Protein farnesyltransferase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF6">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="8">
        <location>
            <begin position="47"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF10445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="435" mass="47021" checksum="F58E47449F36C958" modified="2013-06-26" version="1" fragment="single">DIFNLFPDDLKTTTSEAQEKTEKECLPLLTGDQALGLPLNSHGIPHLNRVKHAAFLEDWIDELPGPYVAMDASRPWVFYWVMAGLSFMDNDVTQYKQRLMETVMPLQNPSGGFGGGHGQSSHCAATYATLLALTAVGGLEVVDRKAMWHFLGQVKEADGGFRMAIGGEEDVRGAYCAMTAITLLNLPLELPPDAPARAAGLTSFLDGLGDWIGKCQSYEGGIAGAPTNEAHGAYAFCALACLSIIDAPYISIPKYLNVEALLTWLTSTQTSPEGGFAGRTNKLVDACYSHWVGGCWALIQAAIAGSTNNNNHTSTKQIPLWNRVGLIRYLLCCGQQPGKRGGMRDKPSTRPDAYHTCYSLAGLSAAMNDFCYNDVQHGSTTDESGRLTAAFQWTAAAPTAEERKALVIDVEDLVVPVHPVFVLPMGVVEQAKMQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>N1QE87</accession>
    <name>N1QE87_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SEPMUDRAFT_127986</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757343.1">
        <property type="nucleotide sequence ID" value="XM_016902183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QE87"/>
    <dbReference type="STRING" id="692275.N1QE87"/>
    <dbReference type="GeneID" id="27899320"/>
    <dbReference type="eggNOG" id="KOG0036">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_2_2_1"/>
    <dbReference type="OMA" id="VISYAEW"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000016">
        <property type="entry name" value="Solute carrier family 25 member 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="13 14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="8"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="77"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="113"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="178"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="295"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="404"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMF09222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="497" mass="54742" checksum="193CDEB3D6951E04" modified="2013-06-26" version="1">MDGESQAQRDARLRSLWERLDTKKKGTLDYEALKRGLGAVNHPLKDADGLIQDMLTACDIDRDGKISYDEFCRFCTATEKELWQLFQSIDQDRSGRLDKGELSSAFERAGVTVSKTRLDRFFSYIDKDRDGTIDFGEWRDFLLFIPTNEPGLSAVLSYYQNTTKLNSEGDVHLSDEAVQGLGYFLAGGLAGVTSRTATAPLDRLKVYLIAQTGSTKETVQAVKSAKPVSAAQHGVRTLWTACQDLWAAGGVRSLFAGNGLNVIKVMPESSVKFGAYEASKRAIAKLEGHDDPKRIKGSSSFVAGGIAGMIAQATVYPLDTLKFQMQCEIVKGGEHGTRLIWHTAKKMWARNGVVAFYKGLPMGLIGMFPYAAIDLGIFDTLKKRAIKRNRARNPSIKHDEDALPNNFSLALMGGFSGAFGASIVYPLNLLRTRLQSQGTFSHPRTYTGIVDVTRQTIQGEGVRGLFKGLTPNLLKVVPAVSITYVVYENSKKFLHLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1QEA9</accession>
    <name>N1QEA9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Calcium/proton exchanger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_151366</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757398.1">
        <property type="nucleotide sequence ID" value="XM_016906767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QEA9"/>
    <dbReference type="STRING" id="692275.N1QEA9"/>
    <dbReference type="GeneID" id="27903904"/>
    <dbReference type="eggNOG" id="KOG1397">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008721_4_0_1"/>
    <dbReference type="OMA" id="WNPFRHV"/>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF20">
        <property type="entry name" value="CA(2+)_H(+) EXCHANGER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="181"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="478"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="507"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="552"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="576"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="218"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="445"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="101"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="151"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF09277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="604" mass="64726" checksum="0AFB56791DFAE0F5" modified="2013-06-26" version="1">MHRIKHAARKSAWHNDPSDPKYSTYNPFGRMNTNPRARAAGDEENGLRQVQSAPHASSPVDTHGKSMDNGPQQTQYHHNTFPMTAEDEHANQHNRGIETFQKSTPSEKANSGQTDTVPPSTIAESAGPASTDGKPRKRKLRAFLPFGKGKHEEDEELARMNTEKSEKSKKKRPKLSLMSQVKAVFGSWINILLVFVPVGIALNYALPHGEDAPKTNGIIIFVMNFIAIIPLAAVLSYATEELAMYIGEVLGGLLNASFGNAVELIVSIIALIQGKVLIVQTSLIGSMLSNLLLVLGMCFFFGGINRSEQHFNITVAQTASSLLALAIGSLIIPTAFGLFANGTGVPTTDSGVTQASRGTAVLLLVVYGAYLLFQLKTHQSMYNEPSKKTPKRSTGRKDAGEANKAMAVMGAAPGAASAGGRVNAENLIHEEEEEEETPSLSVIGAIITLLIATVFIALCAEYMVSAINAVAKSVSQEFIGLILLPIVGNAAEHATAVTVAIKDKMDLSIGVAVGSSLQIALLVLPIMVLLSWFGVGANVDPPNSTLNLDFDGFLVVVLVLSIWLVNYLINDGKSHWLEGVMLMITYLIIAISAWFYPVTGEVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1QES2</accession>
    <name>N1QES2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sec1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_70557</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759081.1">
        <property type="nucleotide sequence ID" value="XM_016909909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QES2"/>
    <dbReference type="STRING" id="692275.N1QES2"/>
    <dbReference type="GeneID" id="27907046"/>
    <dbReference type="eggNOG" id="KOG1302">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016678_3_1_1"/>
    <dbReference type="OMA" id="EFHIFFV"/>
    <dbReference type="OrthoDB" id="10262287at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043155">
        <property type="entry name" value="VPS33_dom3b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF10960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="668" mass="73211" checksum="961A295C476ED500" modified="2013-06-26" version="1" fragment="single">MAAHSAAKAINTQEITDKARRELLLLLESVRGKKNLVIEKSLAGTVGLFVKFSTLQEYGVDKPFFLENHNIDSSQRNIVFVVRGENAKKIRMVAEQIKLVRSESKIDHDFTIIWVPRRTLVSNMILEEHGVLGEANITELHLHFVSLEPDLLSLELDDAFSGLCLRKDPTSVFAAAKALMLLQKQYGLFPRILGKGDNAKRLADLLQKMRNEEDVNASSDSSNTYLTAFGLTPSSLIENLIIIDREVDLPTVLSTQLTYEGLLDEVFGITNNTTEVDSSILGGAPPAHSQNGSTPAPTAATKRKVVLDSSDKLYPDLRDTNFATVGPTLNRIARRLATDSETMHSKDQTVADLKNVVAKLPSYQAESASLKIHTSLAEEIMKVTRGESFGRMLEVQQNLLAGTDATALHENIEELIARNTPLSTVLRLLCLESCLFNGLRQRDLDHFKRQILQAYGYQHALTLASLEKMGLLVPRESHRGYLNPMAGAVGQSATDWNSVRKGLQLWTDEVQEADPTDIAYVFSGYAPLSVRLVQCILQKSSLHQLLTNASKTGGTAAPSGAATGWKGFEEAVARIRGATVDVTQKGSDADASHARKTLRGSKEGPRISIVFFLGGVTYAEVAALRFVNEQLERSGGGNGRRRIVIATTNILNGERAVEVAVEKRTFVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>N1QEZ3</accession>
    <name>N1QEZ3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1688-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_149653</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759884.1">
        <property type="nucleotide sequence ID" value="XM_016905690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QEZ3"/>
    <dbReference type="STRING" id="692275.N1QEZ3"/>
    <dbReference type="GeneID" id="27902827"/>
    <dbReference type="eggNOG" id="ENOG502QR4F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026445_1_0_1"/>
    <dbReference type="OMA" id="VPMFTAD"/>
    <dbReference type="OrthoDB" id="2153176at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012469">
        <property type="entry name" value="DUF1688"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31687">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31687:SF3">
        <property type="entry name" value="PROTEIN URG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07958">
        <property type="entry name" value="DUF1688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF11763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="465" mass="51608" checksum="E027DE113289E101" modified="2013-06-26" version="1">MKRANSTEASPSASIPSVPLPRAPDPQVDPAAYLRSIYAVRERTRLVLEKAKRNQLRHFTVDMSKFPDTAAYVVSIIKRDFDPDYSKIPPHGRWQHFEVGGIPRIDQLMRTWPSTVDDRERTRRLIDLFLVSVLLDAGAGTKWQYKSKESGKIYRRSEGLAVASLEMFKTGLFSSAVDQPFQVDSDGLKKLTVESMAKGLQVTPDNPIDGLEGRTNLLIRLGDSLLNQEIFGPEHRPGGMLDYLLGHPTTHAGSTPVVPIPTLWDTLMSGLVSIWPATRTQIDGVALGDAWPCGSMPSHPTQPWENIVPFHKLTQWLTYSLMVPMQKLAHVQFAGVDLMTGLPEYRNGGLLVDTGLLTLKEEDAQRGLEQYHMNSTRKGQPNMEVVPLFTADDDVIVEWRALTVGFLDELHGEVNALLGLSGDEKLSLAQVLEAGTWKGGREIAEVSRPNTKEPPIMILSDGTVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGK3</accession>
    <name>N1QGK3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_103734</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764462.1">
        <property type="nucleotide sequence ID" value="XM_016900513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGK3"/>
    <dbReference type="STRING" id="692275.N1QGK3"/>
    <dbReference type="GeneID" id="27897650"/>
    <dbReference type="HOGENOM" id="CLU_1147799_0_0_1"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="17"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="44"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF16341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="242" mass="27220" checksum="F74D8B05E7D5AA11" modified="2013-06-26" version="1">MQSSSFLPSDHHLPPTWTCDQCQTSFSKSKLLEQHTKEMKHAGYRCAALGCGKTFTARTSWLSHKKGHTAARTACSKCSKPFKRKDHCREHDFICGKHKRATSLHDNDSSTLSEVHDSGSLAAQSSEAFRVARTLSSLRDQGKDNTPPGWNTPYPIPPEHMTVHCEVCRKFVPAHLLQEHYASETLALQSLFGSREPRETLASHHLSCVISGACQCIRLSSAYFSRENRRKNRTEQSPFFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-12-14" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGR1</accession>
    <name>N1QGR1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_110714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757310.1">
        <property type="nucleotide sequence ID" value="XM_016900861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGR1"/>
    <dbReference type="GeneID" id="27897998"/>
    <dbReference type="HOGENOM" id="CLU_1836398_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="140" mass="15639" checksum="C071226A6E293A74" modified="2013-06-26" version="1">MSHSGAVGSAPNCNFAPMVHPWFSTVHLVFDELCADYYPSTSHESHVFLETRQAFAETPVHVTLHEWLEDSEDDGDYDRDHDTDEEDEDEEGLVLLLYYYGLDDVDMGYAVRAQSSPGKPSGAVTAAVVERLNRNNDGWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGU2</accession>
    <name>N1QGU2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_120095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757345.1">
        <property type="nucleotide sequence ID" value="XM_016901570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGU2"/>
    <dbReference type="STRING" id="692275.N1QGU2"/>
    <dbReference type="GeneID" id="27898707"/>
    <dbReference type="HOGENOM" id="CLU_1190526_0_0_1"/>
    <dbReference type="OrthoDB" id="550577at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110803" evidence="1">
        <location>
            <begin position="23"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="233" mass="25611" checksum="EF6EE0614D446CB5" modified="2013-06-26" version="1">MKSTILTSFLLAATTAIHTALAYSPPLKITSMTTHQPIGSGSTNFYYINFAIQGIPSRRFSSSSSSAYCQISWGDNGWTNPQPYSIHVPTGTWMNCDSTPGSYDGTSAFQFQLFPYFSIGNFTSGVRKISQEWAYGLSNADTAGLTYASLFDGNAVSRYHKLTTTRYFRADFGGVTQDESSSSSNFRARFVAAYTDTLSSTGDCSYPTTEAIRTTSKGIYQQASILFFKRNIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGU7</accession>
    <name>N1QGU7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calcium channel YVC1-like C-terminal transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_165988</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757350.1">
        <property type="nucleotide sequence ID" value="XM_016908195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGU7"/>
    <dbReference type="STRING" id="692275.N1QGU7"/>
    <dbReference type="GeneID" id="27905332"/>
    <dbReference type="eggNOG" id="ENOG502R4J4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014699_0_0_1"/>
    <dbReference type="OMA" id="GYACEFV"/>
    <dbReference type="OrthoDB" id="310870at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052971">
        <property type="entry name" value="TRP_calcium_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056336">
        <property type="entry name" value="YVC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859:SF5">
        <property type="entry name" value="ION TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23317">
        <property type="entry name" value="YVC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="362"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="455"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium channel YVC1-like C-terminal transmembrane" evidence="3">
        <location>
            <begin position="267"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="602"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF09229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="650" mass="73714" checksum="D7477BB8CD7F3E66" modified="2013-06-26" version="1">MATTSPVVAIPEVGGNESLDELVRKLLGFFVQAIETPHAWEELRREEYPRSLRPLVRYLVDEVQHEAIVSALLALKWYFDDLEDGDDRGINETRGLACELVAWRFISHLTYRETIDYLCTDLPTHFGGSSPENGDLEDAEPDEDLEHAGNEQAPLLESPNRPSHRMDDSFYDELPRHYADSDQADFASTFANLSALEIAAVANAKKFLSQRSIQHVIDGIWKGDVVFWNEVSTHSRKHAQVYRKAHSDPYARLRVPLYLKVFEVLFFAGFLALYYIVLVQKQASSVTVPEVMLYIWLASFSYNELVEFSDAGLTFYATDFWALWDLGIISVGCAFFVARMIGLAHHDAYVSDVAFDILSVEALFLVPRICSLLSLHPYFGMLLPVLKAMTVEFIKFLSLVVIMFFGFSTCFSFLARGSYSWGNMNWILIKVFFGSSYLGFDVADQISPVLGPPIMLVFVALTNILLITSLISLLSNKLDKVIEHARDEYLFVYSVYVLEASTSNRLTYFYPVLNLLPLLLRPLRLVLSTQRLRSARIVLLKATHWPLVGLILMYERALTMLDDQRKFGYSGVSKRPNAPTSLRRPISRKPLSTSRLSLLEEQPRAARSPFGAPVPAPARRSESMERLSSHIAELQHQVKTLTDVLLERKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1QH73</accession>
    <name>N1QH73_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitochondrial outer membrane transport complex Sam37/metaxin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_33534</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764656.1">
        <property type="nucleotide sequence ID" value="XM_016908543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QH73"/>
    <dbReference type="STRING" id="692275.N1QH73"/>
    <dbReference type="GeneID" id="27905680"/>
    <dbReference type="eggNOG" id="KOG3028">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032751_0_1_1"/>
    <dbReference type="OMA" id="GYMVHVG"/>
    <dbReference type="OrthoDB" id="5835136at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033468">
        <property type="entry name" value="Metaxin_GST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050931">
        <property type="entry name" value="Mito_Protein_Transport_Metaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019564">
        <property type="entry name" value="Sam37/metaxin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289:SF41">
        <property type="entry name" value="FAILED AXON CONNECTIONS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289">
        <property type="entry name" value="METAXIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17171">
        <property type="entry name" value="GST_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10568">
        <property type="entry name" value="Tom37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Mitochondrial outer membrane transport complex Sam37/metaxin N-terminal" evidence="7">
        <location>
            <begin position="19"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Metaxin glutathione S-transferase" evidence="8">
        <location>
            <begin position="219"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF16535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="426" mass="47667" checksum="B460EDC041100DC7" modified="2013-06-26" version="1">MQLFILPPAFGLPSIDAACIAAVALLQLHVPHAYTIVPTHDEESRPLPLLIDGTAKVSGFNNIVRHLIDKRLLSHSGLSQQQRADAIAITSFIESHAQTLLDISLYVGFENYRLATRPAYSKVLPWHANYTLPPRWRAAARMRTEQLGISSIDVDNVHEDMSNRPEGFDGVGKDQSKSFEEATQKRASLLLGGGKQTLRGLLQKPEHAAVFKLNALADNFFEPLEELLGNSNHLLGVEEGPTAVDCLLVGYLTLMLFPKLPQDWLAGTMRRKYKKLVTYTERICQQLKLGTKVEDVLAISLCKSEAEVLDLRTERNITLSWGTPHHPTISHTMRSFRVGIWNQIPLLGQPNKLELWNVKWHPFFYRNFRTVMLTMVTSFTALGWLSVHTGFLVWPHGEAVQIFGRRRISDFGYLGAAIGGIGAFGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>N1QHE4</accession>
    <name>N1QHE4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_149716</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759980.1">
        <property type="nucleotide sequence ID" value="XM_016905727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QHE4"/>
    <dbReference type="STRING" id="692275.N1QHE4"/>
    <dbReference type="GeneID" id="27902864"/>
    <dbReference type="eggNOG" id="KOG0266">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_23_1"/>
    <dbReference type="OMA" id="LTPDANW"/>
    <dbReference type="OrthoDB" id="17410at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000111">
        <property type="entry name" value="Transcriptional repressor rco-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013890">
        <property type="entry name" value="Tscrpt_rep_Tup1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08581">
        <property type="entry name" value="Tup_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Transcriptional repressor Tup1 N-terminal" evidence="8">
        <location>
            <begin position="22"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="355"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="390"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="438"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="476"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="536"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="578"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="88"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="223"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF11859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="618" mass="66955" checksum="CADF5E752E75445D" modified="2013-06-26" version="1">MYNAHRGMAPGPQPGAIRPGERLAELLDQVRAEFEAHTQRSNENEHSLHAQIQEMELVRTKIYQLEASHLAQKQRYEEEINRLKHELEQRGGPPQGPHSAPSQPPPPAIGHGPANLFQGIMAGGQSAPGLAPPPTEGQGQPGMPGHMQGQGPPGLNQPPLQPHNPFAYGGPQQPGPPGLNGYGGQPPQPTSSPGGSKPRLGGAGPLRGPATPQQNPAAAYPGSPHPITRPTPPPGQAHRDPHHQIAPDFAYTPAQLDQIGNQLAEYDPEKLPPHLKKQGEDWHAVFNPKMQRRLDVDLVHNLAHQSVVCCVRFSADGRFVATGCNRAAQIFDVNSGKQVCHLQDNNTSAEGDLYIRSVCFSPDGRYLATGAEDKIIRVWDIQQRVIKHQFAGHDQDIYSLDFASDGRYIASGSGDRTIRLWDLQDAQCVLSLQIEDGVTTVAMSPNGRYVAAGSLDKSVRIWDTQTGVLVERTEGEQGHKDSVYSVAFSPNGEHLVSGSLDKTIRMWRLNPRGGYPSMGGAVAPQHPKSGECVRTFEGHKDFVLSVALTPDGNWVMSGSKDRGVQFWDPNTGEAQLMLQGHKNSVISVAPSPQGTLFATGSGDMKARIWRYVPYTGPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1QHI9</accession>
    <name>N1QHI9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carboxypeptidase S1-like protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_149756</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760040.1">
        <property type="nucleotide sequence ID" value="XM_016905751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QHI9"/>
    <dbReference type="STRING" id="692275.N1QHI9"/>
    <dbReference type="MEROPS" id="S10.016"/>
    <dbReference type="GeneID" id="27902888"/>
    <dbReference type="eggNOG" id="KOG1282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008523_10_3_1"/>
    <dbReference type="OMA" id="FQEFPGY"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF189">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF11919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="579" mass="64559" checksum="D3964B248B19C31D" modified="2013-06-26" version="1">MALHQLRECPGVRSFSGYVHLPAGALQDLGQKSDYPINTFFWFFESRKDPSNAPLSIWLNGGPGSSSMLGLLAENGPCFINPDSNSTTLNEWSWNNEVNMLYLDQPAQAGFSYDTLTNISHNLVTDRVFLLNDTDPIPPQNATFLVGTYASQDSNRTSLGSVNAAQALWHFAQEWFQEFPEHRPHDGRISLATESYGGRYGPAIFAFFQEMNERIEKGDFNVEGEQHIRHLDTLMLISACLDQLVQGPSYPHIAYNNTYGIETVNQTIYEGMLDSLYKEGGCIDQIYQCRNLSLTYDPENLGHNTTVNDICAKSDSYCSKNVRSPYNLYAGRNYYDFATLDPDPFVPKFYYGFLNQPHVQQALGVPLNFSHSSAAVSFAFRSIGDYNKPGWLEDLAYLLENGIKVTMAYGDRDYACNWLGGEAVSLAINYTNTSNFHAAGYTAIETNSSYCGGQVRQYGNLSFSRVYQAGHEIPSYQPETSYKIFMRALHNVDIATGTVPVTSEDGSIYSSVGIPDTWAIKNDPPQQPLPFCYVLNPRMCSKAQIDSIYNGSAVIRNYLIVDNYTTALFPDVVGNGGIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-12-14" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>N1QHK0</accession>
    <name>N1QHK0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_150673</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758754.1">
        <property type="nucleotide sequence ID" value="XM_016906326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QHK0"/>
    <dbReference type="GeneID" id="27903463"/>
    <dbReference type="HOGENOM" id="CLU_1300361_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF10633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="212" mass="23338" checksum="62FF093CCAFC5D11" modified="2013-06-26" version="1">MYNAVSRVSCMPRLFLTFPCQRKFKIAYLESGWLSKRRPCIRFCRIRSTLLDETSVGMCKVLRGGMPVDVLESLVTNRLTEFLTVVCSGTLSSAPAFRSTTCPSCSVSACIVGASIPYGPAYLIHTAPCTGSLVRHRPAVWKLDEHRHTGHAAPFVRLLAQTSISSGRSVHRRGWLICHGHNDAPKYISATLQPLLGYVPLHATSTAESEFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1QI05</accession>
    <name>N1QI05_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fcf2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_149864</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760205.1">
        <property type="nucleotide sequence ID" value="XM_016905820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QI05"/>
    <dbReference type="STRING" id="692275.N1QI05"/>
    <dbReference type="GeneID" id="27902957"/>
    <dbReference type="eggNOG" id="KOG3100">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075129_1_0_1"/>
    <dbReference type="OMA" id="MELPTHQ"/>
    <dbReference type="OrthoDB" id="10261782at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039883">
        <property type="entry name" value="Fcf2/DNTTIP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014810">
        <property type="entry name" value="Fcf2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21686">
        <property type="entry name" value="DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21686:SF12">
        <property type="entry name" value="DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08698">
        <property type="entry name" value="Fcf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fcf2 pre-rRNA processing C-terminal" evidence="4">
        <location>
            <begin position="111"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="208"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF12084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="238" mass="26736" checksum="A538FC81C5CE08DF" modified="2013-06-26" version="1">MAAALQLPTQATLSPAEDMTDEQIEQELLAATARLQAKSKDTQLQVAKQNESKGITIPKLNTGDLPRPYVSMDGHIATVDASRLVDERYRKLQVRTVEDPVVAKKAAEEKKKATAGDAWYGLPKTEMTPEFKRDIQLIKMRNVLDPHRHYKKDNGPMKAPEYSQVGTIQEGPTEFFTGRIENKKRKRTFAEEVLAGEQETGRFKNKYGQIQNKKTSGKKAYYKAQQDKRKGGIKKGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1QIA5</accession>
    <name>N1QIA5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL5m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_149918</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8 9">SO2202</strain>
        </source>
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        <text evidence="1">Belongs to the universal ribosomal protein uL5 family.</text>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="50S ribosomal protein L5"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ribosomal_uL5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_uL5_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_uL5_N"/>
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            <end position="247"/>
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    </feature>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF12174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="356" mass="39910" checksum="74030A285044E50E" modified="2013-06-26" version="1">MALQEVTTSFLRRLRLAEKPLHSVWTAQCQRYASSDATTTTTTGQEVSELEATEFHATPSDAAEKRLSEYSPLERSRRRRAQLPASRYQFRPPKYFRGPLHPHQPPKGSDPASREYVPGPFSLPRLEQTYHDTLKPDLMTLSYTHYPPGTEPHKKGARLREWTGDSPYYKNRPLRGPRGGDTLKLLRKPITFRNVPKLERVTVHTFVKEAAEDSAYLHVAGMVLQAITNVRATSHDIKASVAGFGIRQGQFLSVTCDLRGEDMYHFISKVVDVVMPKIKDWPGVKGSTGDSSGNLAFGLEPDQVALFPEIEVNYDAYPPKMIPGIHVIVHTSATNDQDARMLLSSVGIPFFGKLIN</sequence>
</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
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        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF11620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="162" mass="18411" checksum="B346FCD30848AE74" modified="2013-06-26" version="1">MMMTLVLERFRDAVAFLVRRTEEVWGLMMMMVGMMVLVVVAVGVGVWVVSASAERGEWQWWSWWWMKRAGERGEDIGQRNYGGDFDDKEADGDEEKEEEEKEKEGESEENGNQHDLGKTRSSNSSTDDDDGEEEIWTTAIRFFAAASSSSSSSSSSLSSWKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJ28</accession>
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    </protein>
    <gene>
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        <lineage>
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            <taxon>Dothideomycetidae</taxon>
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            <taxon>Sphaerulina</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
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            <end position="139"/>
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    </feature>
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        <location>
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            <end position="92"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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            <begin position="110"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF10584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="139" mass="15348" checksum="FEBA4CB1AA87F490" modified="2013-06-26" version="1">MVFSWSDTADKQMLLRIMHLAGPVKLADFDQVAAGMPPGVTAEACRQRLRRIKKQVSDSESSKETTTTPVKRGVATKKIGGAKQKAQKSALGGEAGEWVDDDDGDDEEESPFKKSKIEKDQIKSESKVKSEHDEDDWLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJ40</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name evidence="2" type="ORF">SEPMUDRAFT_146300</name>
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    <organism evidence="2 3">
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        <lineage>
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            <taxon>Dothideomycetidae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016903564.1"/>
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        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF17200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="96" mass="10747" checksum="59A2B570425AC129" modified="2013-06-26" version="1">MHGSLYRSVLPRQPSPSGSHTMQLHDSKHPQQKSEHSRNCSASTESTIQRRLEQVALDCVADPVALSSRSFYYTAQHDKQVSNHIGKTGLGHKEHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJ59</accession>
    <name>N1QJ59_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DHS-like NAD/FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_32066</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765387.1">
        <property type="nucleotide sequence ID" value="XM_016908480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJ59"/>
    <dbReference type="STRING" id="692275.N1QJ59"/>
    <dbReference type="GeneID" id="27905617"/>
    <dbReference type="eggNOG" id="KOG2684">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021544_1_1_1"/>
    <dbReference type="OMA" id="QLHGSIN"/>
    <dbReference type="OrthoDB" id="2919105at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099115">
        <property type="term" value="C:chromosome, subtelomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031934">
        <property type="term" value="C:mating-type region heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005721">
        <property type="term" value="C:pericentric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033553">
        <property type="term" value="C:rDNA heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140765">
        <property type="term" value="F:histone H3K56 deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140861">
        <property type="term" value="P:DNA repair-dependent chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009299">
        <property type="term" value="P:mRNA transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031508">
        <property type="term" value="P:pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046459">
        <property type="term" value="P:short-chain fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47651:SF17">
        <property type="entry name" value="DEACETYLASE SIRTUIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47651">
        <property type="entry name" value="NAD-DEPENDENT HISTONE DEACETYLASE HST4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="6">
        <location>
            <begin position="65"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF17266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="385" mass="42535" checksum="BDF84C74B36D1013" modified="2013-06-26" version="1" fragment="single">MRPRIPSIPYPSPPASQQHSQNGSPAPDGDMAADKDGPPPAKRRRISGKTERTTEHLDLRSDTVHPDQQRQLDRLVNVLHRRQKIVVIAGAGISVSAGIPDFRSSQGLFRTLKEEYNLKGSGKDLFDASVYKDDASTSSFHDMVNTMSRLTKDAKPTAFHHMLATIAQEDRLLRLYSQNVDGIDTGLEPLKTAIPLAKGTDGKWPRTVQVHGGLDKMVCSKCHDLADLEPTLFDGPVPPTCTRCVEVNDIRVGVEGKRSHGIGRMRPRMVLYNEHNPDDEAIGAVTKDDLRKRPDAVIVVGTTLKVPGVRRIVREMCATVRDRKGGVAIWINSDPPPITKDLEDCWDIIVQGPCDNVAKHAAMRRWDEPATSEVYSEVSEGEAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJG2</accession>
    <name>N1QJG2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_103813</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764548.1">
        <property type="nucleotide sequence ID" value="XM_016900518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJG2"/>
    <dbReference type="STRING" id="692275.N1QJG2"/>
    <dbReference type="GeneID" id="27897655"/>
    <dbReference type="eggNOG" id="ENOG502T521">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_379988_0_0_1"/>
    <dbReference type="OMA" id="HIVRMQC"/>
    <dbReference type="OrthoDB" id="3939134at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="515"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="285"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="296"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF16427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="729" mass="81405" checksum="930FAF95F12AF24B" modified="2013-06-26" version="1">MGPLPRPSRDTLLRAKAPSGHRRRSAKQHALPRAARAETYDIPDTPEQLKIPKLRRPRAQALDFSPLRPRQKQQPAASTVQPQDTLANQAAVEDHETAQELHSTADLTHPRRSFRAQATSELTPAEKSVGGAKRHALPSVPAKENDENADSPIVSPRRGGAVVVSTAAPVTPLKRGRSPKEVGSKASRKSASLAKNVPHEYGEGHGEPEEAEPVRRTYKSAKGKGPLIENQDTTRAKPTKIRLSELGYPVQTPTTVNSGGKDESAPNGDPRANEEQDEDVEQTHEAQASTASQKSKVQRVPKRTKAAKLKRKSTTALPKVFAADEELHDDSGRGVEDDGDSLGQQYIVVKNIYTNVVPKVEAMGDGELLDATIDELRLACRSFRQHLRQLRESPDDAELLSGLPRGLETVRSQVEVLCEENADRERNRLQSQSIYFCLFPALVRVLWSLIRCYKALDLQKDTDGMSVTITHVKDIKRFTGTILKLGDSAKRYVRPQIVVVRDVTRGILVPLRKVHNALQREVFEYDEERQREQREARHAQAREAAELEAAHAKAERARWQTIQEKWSRLHVERKLADECIIPLAKRRHLRQPSAEPEQDQNGERFTRVEVFRPRVGPQPGLVNRIKSQVWPRQSQTALVEGLMTWAGDALVFERIFRAYCGRNGPLNPYNVTEIVVQAALLKHVLESDCDPHAEDAAWVAQIPDWTKPDVLMQQLQAPISEGGSDVDSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJH8</accession>
    <name>N1QJH8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_57748</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765507.1">
        <property type="nucleotide sequence ID" value="XM_016909449.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.N1QJH8"/>
    <dbReference type="GeneID" id="27906586"/>
    <dbReference type="eggNOG" id="KOG1202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_6_1_1"/>
    <dbReference type="OMA" id="CKTWDAT"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.366.10:FF:000017">
        <property type="entry name" value="Non-reducing polyketide synthase aptA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.366.10:FF:000002">
        <property type="entry name" value="Probable polyketide synthase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000011">
        <property type="entry name" value="Sterigmatocystin biosynthesis polyketide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.110:FF:000001">
        <property type="entry name" value="Sterigmatocystin biosynthesis polyketide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030918">
        <property type="entry name" value="PT_fungal_PKS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04532">
        <property type="entry name" value="PT_fungal_PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF37">
        <property type="entry name" value="SI:DKEY-61P9.11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22621">
        <property type="entry name" value="CurL-like_PKS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="8">
        <location>
            <begin position="386"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="9">
        <location>
            <begin position="1318"/>
            <end position="1628"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="1711"/>
            <end position="1787"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="5">
        <location>
            <begin position="1318"/>
            <end position="1453"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="5">
        <location>
            <begin position="1481"/>
            <end position="1628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1657"/>
            <end position="1708"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="5">
        <location>
            <position position="1350"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="5">
        <location>
            <position position="1539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF17386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1787" mass="193939" checksum="E1EAE5AEFBA4C00E" modified="2013-06-26" version="1">MEIIYFSNEFPRDDLQGVLRKLHNHSKDRRHTVLAQFIADATRSVKEEIRTLPKALKACFKPFSTLFQWAEDTELREGPLNGAVDGVLLSVLQLATYIGYAEEHPDELFNFGNTCLTGLGLGLISSTAVALSPTLAELPLAGADAVRLAFRMGILVTDISADLEARVEGESPDSWAYVVHNVEPDEAQHQLDLFNFKERLPETGKISLSAYSRTSVTVSGPPARLKELFKKSQYYRDARSIALPVFGGLCHAPHIYDRSHAQRIVREATLNCNEGKRLLPMTPVYCTSTGKPYVAQDALELLENVILEPLTQPIIWDHVISGIVDRATATCAQTCTIYSFGPSIPLKELTESMGARITEFNTDSVNIMGWINESTPDELNSRGSAQAKLAIVGMSCRLPGGATSTEKFWEVLEKGLDVSRKIPADRFDIDTHYDPTGKQLNKSMTQYMCAIDEPGLFDAPFFNMSPREAQVVDPQMRLALVTAYEALERAGYVANRTASTLLQRIGTWYGQAADDYREVNQGQEVSTYYIPGGCRAFGPGRINYYFKFAGPSYSVDTACSSGLAAIEVACQALWNGEVDTAVTGGMNILTNPDGFAGLNCGHFLTKTHNACKTWDATADGYCRADGIGSLVIKRLEDAEADNDNILGVILGAGTNHSAEAVSITHPHAGHQAYLARQVLRQAGVDPLDVSYVELHGTGTQAGDHEEMQGIMEVYAPLSGRRSKNQPLYIGASKANVGHGESVAGTTALIKTLLMLQKNAIPPHVGIKTEINPRFPKDFDKRNLHIAFEKTTWPQHPGKKRIAAINNFGAAGGNTTMVLEEAPARVPAEADTRQLHVVAVSAKNKTSLAGNLERLQAWIENNPEVSLADLSYTTTARRQHHNHRVAIAATDLKGLQKELAKKLAAADSHQPIPKSGAPPVAFCFTGQGAAYKSMDLELYREVPSFRSDFNHFDSLAQRQGFPSIIPAVDGSFPKEHAHSPVVTQLSQVCMQMALAKYWASLGIKPDMVLGHSLGEYAAMYVAGVLSANDTIYLVGKRAQLLEANARVGSHQMMAVRASLAQIKEADGGLQYEVACVNGPSDTVLSGTVEQMDAVSAPLGAAGYKCIKLDVAFAFHSAQMDPILDEFEEIARTGVVFKEPIVPVISPLHGKVIFDGKTLNAKYCRDATRGTVNFLGALESAQEISTITEDTVYVEIGAHPVCCSFVKSSIPALNLAVPSFRRGESNWTTIAQACTAIHLAGLDVDWNSYHAPLEKSLTLLDLPTYAWNEKTYWLQYNGDWALTKGNTFYTAEKEAAAKAAAATGSVRSNAASPIKTSTVQNIIEEHFQDVAGTVVMESDLMQADFLAAAHGHKMNGCGVVTSSIHADIAYTLGEYFYKKLNKKAKKVDMNVANLYVSKGLVANANTKNPQCIRVTVTTEDIRTNVANLYWQNVDADGNAADVFAEANLVFGDATEWLSTWAPMTHLVQGRIDALDAQARAGKATRLSHNMAYTLFGKNLVDYHHKYRGMQAVTMNELEAYADVELTTEKGGVWTVPPYFIDSVAHLAGFIMNCSDAIDTQNNYCVTPGWKAMQFAKPLTPGAKYCSYVKMIPTVEDPTVYFGDVYILQDGVIVGMVGGIQFRRFPRILLNKFFSPPDKSEPISANKSAAPLPKPAALPVAAPVSKPTPSAPAAPPMVRVDSGTGSEPEKTKEAAPAPAPAPAPAVETAADTATDTSSVTYKALELIANEAALEISDLEDDVSFAALGIDSLMSLVISEKFRSELDIKVGGSMFLDYPTIGDLKAYTDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJM8</accession>
    <name>N1QJM8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_146473</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765562.1">
        <property type="nucleotide sequence ID" value="XM_016903673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJM8"/>
    <dbReference type="STRING" id="692275.N1QJM8"/>
    <dbReference type="GeneID" id="27900810"/>
    <dbReference type="eggNOG" id="KOG1310">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001866_0_0_1"/>
    <dbReference type="OMA" id="FRVRYGN"/>
    <dbReference type="OrthoDB" id="4869960at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045717">
        <property type="term" value="P:negative regulation of fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045151">
        <property type="entry name" value="DCAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574:SF40">
        <property type="entry name" value="WD AND TETRATRICOPEPTIDE REPEATS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="40"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="90"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="165"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="848"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="351"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="746"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="960"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="378"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="759"/>
            <end position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF17441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1025" mass="113363" checksum="605A9FAD9F031893" modified="2013-06-26" version="1">MKANFITKLHLRELSDSQRYRRRLYSDRHLVTGLDIVQELDGHSGCVNALSWSSDGHLLASGSDDVHVNIHRYLPGDDSTQPLKLTTSVATGHTQNIFSVKFMPHSADKTVVTAAGDGEVRVFDLEYAGSAGHASRASALASVGRRRRGSQTTYLTDGNTNARVYRSHGDRVKRIVTESSPHLFLSCSEDGEVRQWDLRLPSSAYPPSRGFRFGHDSSAPPPLISYKRYGLDLNSISCSPSQPYYIALGGAHLHALLHDRRMTGRDKLKEKGAHLLPISQLSSEDQELLTSATQCVKKFAPKGQKKMRRSDNGHVTALKISDARPDEIVVSYSGDDIYSFDLLREPNADKAFRDSGQRKRKRVAAGSTASLAHGAADPSKRRIEHSATHSNNDASLRIRYQNGQSEDIPLSAGDQLTAPVTETQRAARHIADLVLRIKVSMFDSGSSTNAASFHNALELAASAIPSMDAIMRGWRYPLDPGPEQIYEQQKLRYHRESSRRFVQAAGTLARAIIGGSTVPAGPLAAHFTSVEARRSDLAVRQQELFSYEFLKSILLWLDSGVGRLIEGFTRPEDMPTTSKAASRLPISESEAGSEAVDEILIPYLLQLASDRPIVNVETNRFEADTERQLFENESAAVFAFAAAVRKPFADLSSAGGDIDTQDRITACRFWASEVARGVLLNATRGLKFADVDRAFGGLGHATREATTDESRINLLHPHDEDEEVNVRTIDMTDDSGQTAVALMVDDTESQQQREGISESNDDDDAVTSDEEEEEDEEEDDETSLSESSSDPDEEDGVPNLGVPRFIYTAAFERQRLKSGVEPDVFCAKPFRNYTGHSNTRTVKDVNYFGNDDEYVVSGSDDGNFFIWDRKTTKLVNILEGDGEVVNVVQGHPYETMLAVSGIDNTIKIFSPDGRAREEARLGRGVNPNPPSSPTPMRIGVRIARRRPQPQQFDEDGDAIVEPTADQSDSDEYLAPSGLQSRRRMYDSRRIIEQNRLEHARGRQDHGITISPDIVQYLIQHGLLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKA1</accession>
    <name>N1QKA1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA mismatch repair protein MSH5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">MutS protein homolog 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SEPMUDRAFT_56285</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764803.1">
        <property type="nucleotide sequence ID" value="XM_016909394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QKA1"/>
    <dbReference type="STRING" id="692275.N1QKA1"/>
    <dbReference type="GeneID" id="27906531"/>
    <dbReference type="eggNOG" id="KOG0221">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002472_8_0_1"/>
    <dbReference type="OMA" id="CSVYFMP"/>
    <dbReference type="OrthoDB" id="29596at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051026">
        <property type="term" value="P:chiasma assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03281">
        <property type="entry name" value="ABC_MSH5_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001067">
        <property type="entry name" value="DNA mismatch repair protein MSH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011184">
        <property type="entry name" value="DNA_mismatch_repair_Msh2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF20">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005813">
        <property type="entry name" value="MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0469">Meiosis</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="13">
        <location>
            <begin position="674"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMF16682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="852" mass="93971" checksum="BF5AED4ED754C942" modified="2013-06-26" version="1">MEDMPAGAADIVDALKLFIEPTVILVSTKCNEEAINRLDPELRTQRASVDARSDQTRLPYLLECRPNAEFGYESGKVKLANLHIGLPDGPTVTYVVPGDVVANDDFPAHEDEKSGRQCAILRLAGLVNMDSRITVGCAGAVLSYLQRRKATTFLPGDRDAEAMFRIATVEMFSLGGSMFINADTLQSLQITTTESHPNAQQQGPASKNWSRGSKEGLSVYGLFHNLAKTAQGRHLLRQFFLRPSLNMDVINERHDTIGAFIRPENAATLGQIANTLAGVKDMRRVTTDLRRGIRSGVNNNQPITTSVWGRMRDYTFAALELTDLLTQVVGSEGLVVHRKIAEQFNKLHLAEVGALISDVVDFELSKYAKRTVVLHGISDELDDAKRTYEAIEDMLSQVASHIARQVPADLKSKVNVIFFPQIGFLISIEREEDDIAVPYEGPDPAEPWEQMFTSSTHAYYKNTNTMELDENYGDIWGCILDMEIEIIQNMAQRVLEHEELINTTSDICGELDSLVALARGAVQYRLVRPNMTEQNIVRIKDGRHILQELTVPAFVPNDAYLLGGCGDDTAADPRECKISADPRITQPLPPDAPSVLMMTGPNYSGKSIYLKQVAIIVYMAHIGSFVPANYATIGLTDAILTRISTRETVSRIQSAFMIDLQQASVALNMATRRSLLIVDEFGKGTESYDGAGLAAGVFEHLLQRGPECPKVIGATHFHEIFESGFLPPRPALGFGHMEVQVDDAQSVVENQITYLYNLRPGRSASSYGTMCARINGVDAIVTDRADELIALASKGEDLTEACAKLPKEEMLDLRRAEEIARAFLQIEHFGGPRQILDDLLDQPMSVVTTTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKR7</accession>
    <name>N1QKR7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PLC-like phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_161036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765977.1">
        <property type="nucleotide sequence ID" value="XM_016907920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QKR7"/>
    <dbReference type="GeneID" id="27905057"/>
    <dbReference type="eggNOG" id="ENOG502QT3N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024117_3_1_1"/>
    <dbReference type="OMA" id="HPRECIV"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08586">
        <property type="entry name" value="PI-PLCc_BcPLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF148">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-SPECIFIC PHOSPHOLIPASE C X DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidylinositol-specific phospholipase C X" evidence="1">
        <location>
            <begin position="5"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF17856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="330" mass="37392" checksum="6A63A6BB61E777C5" modified="2013-06-26" version="1">MALVNDEDLVSSLSIPGTHDSAAYTQPWPFVATQTMNIAEQLHAGIRYFDLRCGVVNNSTEMVHGPRLLGLRLQTVLDTMYTWLDSHPTEGLIVQIKEDRKSEQSTVPFWQAIYQNIAAKSERWRTANTTPSMGELRGKIQLLRRYSAPSRMAYGIDVTQWQDNPSTPFTIYTWHQVQLTIQDHYNFSEPMALPSLLAKKGGDVSGLLQKAYNDPDPCHWYINFTSAYEFNLYYQLTPRAIAVGAYYGFRWEQGMNPRLSNSLRVNPGRRRLGIVAMDFPDNGSDDLIQLIIQSNFAPGRMSWHMILLGLSLFAGSSDGTKRCIDYLLGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1QLS6</accession>
    <name>N1QLS6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DnaJ-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_150017</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760452.1">
        <property type="nucleotide sequence ID" value="XM_016905916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QLS6"/>
    <dbReference type="STRING" id="692275.N1QLS6"/>
    <dbReference type="GeneID" id="27903053"/>
    <dbReference type="eggNOG" id="KOG0714">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017633_0_0_1"/>
    <dbReference type="OMA" id="MPIRKEG"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006413">
        <property type="term" value="P:translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000002">
        <property type="entry name" value="Dnaj homolog subfamily b member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000013">
        <property type="entry name" value="DnaJ subfamily B member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051339">
        <property type="entry name" value="DnaJ_subfamily_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078:SF553">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="6"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="166"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="315"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="167"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF12331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="373" mass="39882" checksum="242AF6C7854C95BB" modified="2013-06-26" version="1">MVSDTKLYDRLGVSATASQEEIKKAYRKQALKNHPDKNPAGAEKFKEASEAYEILSDPEKRRNYDNYGYDFITGNGPPPPEPGGDNPYAGAGGFGAGGMPGGFGGMGGGPGRTFHFTSSNGRGGGGAFGGFSDPKDIFAEFMRGSGGSMGGGGGGLGGDDDDFFTSFGGGSFGGRPAGGRSAGSQQYRRREPEPETTVVEKNLPVSLEEMYNGAQKKLKVQRKTYDAQTGKQNTEDKILSVPIKRGLKAGSKIKYPDMGDQVEGGVQDLHFIIKEKPHPLFTRDGDDIKHTVEISLKEALTGWSRTVQTIDGKQLSVSSAGPTNPDWVERFPNQGMPKSKTPTSRGDFVVGVKIKFPTSLTAQQKQQLKEILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>N1QLU0</accession>
    <name>N1QLU0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GA4 desaturase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_109112</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760477.1">
        <property type="nucleotide sequence ID" value="XM_016900767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QLU0"/>
    <dbReference type="STRING" id="692275.N1QLU0"/>
    <dbReference type="GeneID" id="27897904"/>
    <dbReference type="eggNOG" id="ENOG502T40E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042688_4_1_1"/>
    <dbReference type="OMA" id="SCELRVW"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF3">
        <property type="entry name" value="OXIDOREDUCTASE AN1597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF12356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="360" mass="41071" checksum="6BCB40F0F01D2FCC" modified="2013-06-26" version="1">MTTQTITEEVSSTQKQPDVVQGIFTYYDGPKPDVDDTTMLWGKNKYLITKTEPVKDLRSLSKPLSEYNHDDDGIQIFHMPDTSVIQGNLYDHEYVQNNYRQQLGHFIKEKLGLKHCILWGHLVRDVPREVHTKVGEKQVAFPTASGTTAFHLAHVDFSPAGSRAFLRSAGTPDYFEILNNSYIAQEDRAAFFALREKIIAAEETAMRKVGIDPAAEKDGKGGHWDWDGSGYEGPRYGVATLWQPINQVERDPVAFSLSPDRDFKYTGLHRKYHQLGHESMGEFYFENMLVHPEPSQEWAYISNQKPEEVLMINFYDTNALKVSDGSSKSMRVHGAFHLPGTEALPPRRSIETKLFYMYDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1QLU4</accession>
    <name>N1QLU4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_160184</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764909.1">
        <property type="nucleotide sequence ID" value="XM_016907887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QLU4"/>
    <dbReference type="STRING" id="692275.N1QLU4"/>
    <dbReference type="GeneID" id="27905024"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_13_7_1"/>
    <dbReference type="OMA" id="AGYVWIY"/>
    <dbReference type="OrthoDB" id="2585655at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000318">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF2">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="63"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="497"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="501"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF16788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="536" mass="59383" checksum="A87C67BF54511530" modified="2013-06-26" version="1">MVASSDLEIGQRATNTSLGQVAHLPQEHQDYLIRRHGTLDLDPVPSADPADPYNWPEWKKLSNLMCVAFHAMISHFIAAAIIPAYENIAEDFSISITKASYLTSLQIAIVGFAPLFWKPISNRYGRRPVWLISTLGSALLNVGCAFSDSYSTMAVCRAFAAFFISPPVGIGSGVVTETYFKKQRGQFMGLWTLLLTLGPPLGPFVMGFVVTQTGNYRWIYRVLAIINGVQFLFALFLQPETLYIRKGVQHVGSAFKQEYLTFGRLDPKPLKMYEFIQPLSLFKYPSILIPTIAYSMVFGFCSVLLTVEIPQLFIPKFGFNAQQIGLQFLGIIIGSLIGEQIGGRLSDFWMHRKAKQMAYHAPPPPEHRLWLSYFGFVLAMVGLIVFGVRFQQLPAHQYDVSPIVGIAISAVGNQIVTTVSTTYAIDCHFEHSASIGIFINVIRSTWAFIGPFWYPSMLSSLGGSGSGGLMAGLIFLFSIIPMAIVQWKGKQWRRSTQGKISSPLPQSQSSSSEPAAAAAAEKDFIMRNEETKKEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>N1QM85</accession>
    <name>N1QM85_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_145701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016903214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QM85"/>
    <dbReference type="GeneID" id="27900351"/>
    <dbReference type="HOGENOM" id="CLU_1723477_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF16464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="152" mass="17869" checksum="BDBB0AA5E8792D61" modified="2013-06-26" version="1" fragment="single">MTTTRRRRRRRRNHHPRKEEQQQQPLYNDNYDDLHSTFSQINSTHGGYSSSNYNHSNINDITTFGEEEVEVEEEEEEEVEEEPRRGRTRTRTRWGEEEEEEKNGNRWLPPSPSPSVSRGGGVIMGRGTVATAVEPIGGYYYETRVVEPEWTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>N1QME5</accession>
    <name>N1QME5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="6">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_146508</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="6"/>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765623.1">
        <property type="nucleotide sequence ID" value="XM_016903697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QME5"/>
    <dbReference type="STRING" id="692275.N1QME5"/>
    <dbReference type="GeneID" id="27900834"/>
    <dbReference type="eggNOG" id="KOG1872">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017549_2_0_1"/>
    <dbReference type="OMA" id="FKSDAEY"/>
    <dbReference type="OrthoDB" id="333239at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061136">
        <property type="term" value="P:regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02657">
        <property type="entry name" value="Peptidase_C19A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044635">
        <property type="entry name" value="UBP14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982:SF1">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="25"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="108"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="385"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="406"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF17502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="584" mass="65157" checksum="7D961993808A611D" modified="2013-06-26" version="1">MAEIAIKVKHQGKVHDLEVDVENGTGEDLKVQLYSLTGVEPDYQKIVAKKMVKDDTLLKSLGLKPGQTITLIGNPSDKVVIDAPTEKMKFAEDMTEAELAQQEGAIPAGLQNMGNTCYANATLQTLRAVPELIEELKVYKPAAPTAGPSSSLFSAEQLAQHGLGGLSGGSDLTSALGDLFQQMNETQQGFPPLMFLTALRQKHPQFAERAKNGHGYAQQDAEEVWSQLVQNLRDTLKLKDDPNGYKTWVDKYMGGKFDVTTTCKEAPDEGVSTNSEDFNDLKCNINVEVNHMREGISIALNEELEKNSPSLGRTAIYARQSDISRLPKYLPIHFVRFFWRKDTGKKAKILRKVTFQHEIDVTEFCTDELRKKLIPVRDHIREVRKEEEDVVRAKKRQKRINQQIEDASKDAKVRGDEPLQKKLQKEKERESKATGPDSEAELAQQKKSNSAQKDTAMGGTEEEEVYKTDEQIEQERAASILASKKELLKLVHPDLAKDPASNQTGLYELRGVVTHQGSSADSGHYTAYVKKTAAPGKEEDGKWWWFNDDKVQEVDSEKIETLSGGGETHSALILLYRAVPLPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1QMU6</accession>
    <name>N1QMU6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_122303</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764990.1">
        <property type="nucleotide sequence ID" value="XM_016901760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QMU6"/>
    <dbReference type="STRING" id="692275.N1QMU6"/>
    <dbReference type="GeneID" id="27898897"/>
    <dbReference type="eggNOG" id="ENOG502SHU0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019189_13_0_1"/>
    <dbReference type="OMA" id="MMLFAQN"/>
    <dbReference type="OrthoDB" id="2831558at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF2">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="101"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF16869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="575" mass="64875" checksum="10B96857178D44D6" modified="2013-06-26" version="1">MAVAKKARDGPAVEESRPHAVASGFAIARNMHHKPGPTWTMEAVSKERLPHDAEKEFFHFTRGRFIHNEQHELSQRHRTFNVAELARHAAHAVQADRCLRVTKCPDGMYNRVLLFSMDNGKEVIAKIPNPNSGRPHFTTASEVATMEFAREVLGNPVPKVYAWSSRAQETLVGAEFILMEKMNGMELEHFFPAMKIQDRLEVMKTVARYQQSWASVSFEQFGSLYFAEDVGGSAHSPLTYLDHDGRKVTDPRFVVGPSTGREMFDDGREDIEFDRGPWKSLEDYHIAIGKRELACVQHISQLPPSPVSLRGPGLYQPTREKKVKALETYLKLFKHLLPTDSSLRSAHLWHGDLHGGNIFVDPANPTQIVGLIDWQCIELSPLYFRARQPHFIDHEGPTIHGLGRPPLPPNYDQLEASEKREAKALYLDQSLCALYRIFVNKICPKIYACFEFQESSAFMLLLLARNILIDGEAAYMVQACELKDDDEMWQTLTGGGEAPGTTTAFPLSFSPTELQTIEADMELAEVGMAAMRHMREILGEELFPISGYVSPDRYQEAVDAIRQTRELVLAELTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1QN15</accession>
    <name>N1QN15_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ethanolamine kinase</fullName>
            <ecNumber evidence="3">2.7.1.82</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_146763</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the choline/ethanolamine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.82" evidence="3"/>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765953.1">
        <property type="nucleotide sequence ID" value="XM_016903849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QN15"/>
    <dbReference type="STRING" id="692275.N1QN15"/>
    <dbReference type="GeneID" id="27900986"/>
    <dbReference type="eggNOG" id="KOG4720">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012712_1_1_1"/>
    <dbReference type="OMA" id="FALIPKY"/>
    <dbReference type="OrthoDB" id="10267235at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004305">
        <property type="term" value="F:ethanolamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05157">
        <property type="entry name" value="ETNK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603">
        <property type="entry name" value="CHOLINE/ETHANOALAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603:SF66">
        <property type="entry name" value="ETHANOLAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01633">
        <property type="entry name" value="Choline_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="203"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF17832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="436" mass="49472" checksum="5626F518F582A8AF" modified="2013-06-26" version="1">MSASHPPPGPPPHDATSTDPQPSRTDSPLSLRHIALKFDNAAPEASALRLVEALDPTWKTEEGPVEFIRFTDGITNTLMKAVKRRAGLSALEVDRNAILLRAYGQGTDVLIDRERELRAHMLLASIGLAPRLLARFDNGLMYAFIPGHVCSHVDLAKPDVYRQVAKRLGEWHSLPIAAITSTPLLDCEEDAQKKRDVAAKPVNGNSNNSNNKNNTRPYPNTWTTMRSWIEVLPRNTDEERQRVKTIETELAWVESKLGHTVFDQKAFVFAHHDLLCGNVIVDIHSDAKEKPVSFIDYEYATPGPAAFDIANHFAEWAGYDCDHACVPTKAQRREFIQQYVASYRYHTISDAPTTIEIDFQKDIDTLFVQVDLFRGLPGFYWGIWALIQATISQIDFDYSKFAEGRFKEYWSWKEEVTGERKKAGREQYVREKKWAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1QN85</accession>
    <name>N1QN85_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_105128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016766073.1">
        <property type="nucleotide sequence ID" value="XM_016900565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QN85"/>
    <dbReference type="GeneID" id="27897702"/>
    <dbReference type="eggNOG" id="ENOG502SVDD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_422824_0_0_1"/>
    <dbReference type="OMA" id="ANIGHQF"/>
    <dbReference type="OrthoDB" id="5426563at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="606"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF17952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="648" mass="71793" checksum="E4563F0DFF9A739F" modified="2013-06-26" version="1">MDWTGGTRRRYAQAGKNIVVQKQKAHFAKVRSAGHPHPPRSMPDFMREAVESKSYRQAKASQQHRGSTTLRSEGGSRSSRSSEARCRRRAADVRDQAVPADMTDEERKIQSARRSLLARSDWLGLNASRPVKVQFPAERDVERIGKRRKVLKTSRNGPREFQQRRVTPPFQHRERLMQPILSDDGRGESIDIKIGTGALAGTQTELSRPPHVVANTSMRQPSTEFGPLSEESMLMGEEFDDVGTTAERLFCTDNNRTSQCSALDEHQDWKSCTGYAAVNPLERWPVMQQTNGFDQDTPHVPSEPIILPHDAPFRDEEFSDSVALGLGAQDVTRQHTQNALIDSPSYRYSPQPTAIPCATWDMAGATVLDDEGLWRRTLRIRTDAPSEASIAALKSSSLHRTQSAFSIAPQRPVESIGALRQMQYTPTPRVDPPARRFGPLSKGLDETPALISKLMPARSSHATNDDEGQIEPSAVDGAEEEDVLWRTFILGSQSSDSNSLAFNNKTPDEEGVSDPAPRLLCDATSDQPRSDRVTAGGSIYDLALTTYSAPASSTQHGIENTSLMGHAATAHQEVDDIEDEDVPQPVKPQRLRNNIPASAKVLDSKRFIRRKKHSRPGALPKPSRFQPSTRFRATPVDKSVYDIPSTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>N1QND3</accession>
    <name>N1QND3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">A/B/D/E cyclin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_146287</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin AB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765305.1">
        <property type="nucleotide sequence ID" value="XM_016903553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QND3"/>
    <dbReference type="STRING" id="692275.N1QND3"/>
    <dbReference type="GeneID" id="27900690"/>
    <dbReference type="eggNOG" id="KOG0653">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020695_10_2_1"/>
    <dbReference type="OMA" id="FMAYRPS"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044772">
        <property type="term" value="P:mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20568">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20512">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000001">
        <property type="entry name" value="G2/mitotic-specific cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000005">
        <property type="entry name" value="G2/mitotic-specific cyclin B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046965">
        <property type="entry name" value="Cyclin_A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001771">
        <property type="entry name" value="Cyclin_A_B_D_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 5" id="KW-0195">Cyclin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="267"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="8">
        <location>
            <begin position="360"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="364"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="80"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="19"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="142"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF17184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="487" mass="54174" checksum="891F9732952C224A" modified="2013-06-26" version="1">MPPARTARRTVTDENAENAGTTRLTRAKAAALDHAGAGDPPKKALTTKRTTTVSTTGTLGARKRTALGDVSNVAKKELVDNGDAKKETLSKGTLSKAVKPAGIQKPVGRTSSTRPVLGARPANASSELKRPASGSGIQTGHAIKKRNTSTSKPKRVAVEEDEDEDAENVPPPKNGASADSIKKTSPKPAVTEPVDLEEHEEEKSLEELIKEAEDLDTEDLGDPLMVAEYVHEIFDYMREAEISTMANPDYMDNQGELEWKMRGILVDWLLEVHARFRLLPETLFLAVNIIDRFLSCKVVHLDRLQLVGVTAMFIASKYEEVLSPHVQNFVHVADDGFKDTEILSAERFVLATLDYDLSYPNPMNFLRRISKADNYDIQTRTLGKYLLEIACLDHRFLKYPPSQVAAAAMYLARLALDRGEWDATLAKYAGYTEGDIRPVFKLMVDYLYAPVMHEAFFRKYASKKFLKASIVLRQWAKKWGPTYLDGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNE0</accession>
    <name>N1QNE0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trafficking protein particle complex II-specific subunit 65 IgD3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_30351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765325.1">
        <property type="nucleotide sequence ID" value="XM_016908465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNE0"/>
    <dbReference type="STRING" id="692275.N1QNE0"/>
    <dbReference type="GeneID" id="27905602"/>
    <dbReference type="eggNOG" id="ENOG502SGQ1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015118_0_0_1"/>
    <dbReference type="OMA" id="IFSWTVY"/>
    <dbReference type="OrthoDB" id="5345392at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055420">
        <property type="entry name" value="IgD3_Trs65"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024662">
        <property type="entry name" value="Trs65"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28159">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX II-SPECIFIC SUBUNIT 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28159:SF1">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX II-SPECIFIC SUBUNIT 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12735">
        <property type="entry name" value="IgD3_Trs65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trafficking protein particle complex II-specific subunit 65 IgD3" evidence="1">
        <location>
            <begin position="377"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF17204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="518" mass="56067" checksum="DD2BE3D02256A78B" modified="2013-06-26" version="1" fragment="single">RSCFEQVAHSAVLDVLLPRHPPVDVAALIAAGTPTEVSRVPVRRNLFFDENANILAVLKTAATERDLRDILPHLELIVAAHATDAVPQGSGAAAFASGKHDLNTKTVSAGSFKDIVTAHDHSYVVWEPCLHLSRPPARLQRPAVYFTANLVLSDQQQDSPNKLSAPVLASFEPLSANVLEPLDSGRVQGAPNVYMSASKITKVAPKPSTLSDAAKSIRGATRRAFPLLPALFTRIRYSNLPGAVVASLHLEPSHILSGSIRILEAELTGSNAHIEDLTRIKLPLEACGGDETILLYKIVNDSEHPRGGSQISISIRAEVLLNQGSQIVLEIDWQTDLSHTLQSPLYQWSRPAAVSSHRKSHSILSLGTLSGEHAPARAEVASGGVTFIFTRKPLVQASSDFKLLVHCNNRSSRPRRFGLMIVQTRKSWLIKQSAPADVAVSDVGARVFCTPPMERSKPSNALDLNADLRIGPLPPGACFEAHMSFVLLRPGVLDLGTIRIIDLDTRQTVDVEELLDIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNF9</accession>
    <name>N1QNF9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit D</fullName>
            <shortName evidence="5">eIF3d</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_35759</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit D family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765370.1">
        <property type="nucleotide sequence ID" value="XM_016908618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNF9"/>
    <dbReference type="STRING" id="692275.N1QNF9"/>
    <dbReference type="GeneID" id="27905755"/>
    <dbReference type="eggNOG" id="KOG2479">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024521_2_0_1"/>
    <dbReference type="OMA" id="FMDKRDN"/>
    <dbReference type="OrthoDB" id="16538at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098808">
        <property type="term" value="F:mRNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002191">
        <property type="term" value="P:cap-dependent translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03003">
        <property type="entry name" value="eIF3d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007783">
        <property type="entry name" value="eIF3d"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12399">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12399:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05091">
        <property type="entry name" value="eIF-3_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016281">
        <property type="entry name" value="EIF-3_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="91"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA gate" evidence="5">
        <location>
            <begin position="305"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="91"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="120"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="165"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="357"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF17249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="578" mass="63958" checksum="B36EA20C276C97A7" modified="2013-06-26" version="1">MPGLPPGLLEAIEALPASDSWGPPTTTETTLNGIPYAPFSKGDKLGRMADWTAEGKEREGRGGRAQYNNRYRDQVYGATGLQTAFQIEGTNEESSFSLVDRSQPTTRGRGFGRGSAVFGRGRGARGGAPGQRGGRGTFQRVGGRGGQQQYDSRGGRGGRGGRRGGWKDWDKPQRNREASVQPKDSWRMLDEIDFNRLQKLNLDTGDGEDLDDYGFLYYYDRAYDKQPGAPTSMRKLTVLDRAAYNVTTSSDPVIQELADKDEAQIFAADNILSMLMCAPRSVYSWDIIMLKQGNKIYIDKREGSSLDMVTVNENAADAPLELSEGNKDHINAPGALKDEATHINNIFPLQVVQESETSKRDMSHEHPFYDPASETDPPASKAYKYRRFDLSLEADAEPLHLIVRTELDAVVKNNISGEDQFLTIKALNEFDNKAQGSGGALDWRSKLASQRGAVVATEMKNNSCKLARWTTQAILAKADLMKLGFVSRANPKSTTEHVVLGVLGYKPREFASQMNLNLNNGWAIVRTFVDMVMKEDDGKYVLVKDPNKPTIRLYNVPPTTFEEDDVEAQSTIPEGDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNJ9</accession>
    <name>N1QNJ9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GST C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_27515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765944.1">
        <property type="nucleotide sequence ID" value="XM_016908427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNJ9"/>
    <dbReference type="STRING" id="692275.N1QNJ9"/>
    <dbReference type="GeneID" id="27905564"/>
    <dbReference type="eggNOG" id="ENOG502S090">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039475_0_1_1"/>
    <dbReference type="OMA" id="LWVHQLQ"/>
    <dbReference type="OrthoDB" id="414243at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03192">
        <property type="entry name" value="GST_C_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF263">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST C-terminal" evidence="1">
        <location>
            <begin position="117"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF17823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="285" mass="32025" checksum="237EA5BBB5349B87" modified="2013-06-26" version="1" fragment="single">PKYELLYHPGIPGRGEFIRLALESQKIPYTDIANPSSSSSSSAHENGYATVQRICMNPHALESAAGNPPVFSPPGLRVCFASKGGQGREGEEGNRKTLVISQTPNILIYLGEKIPGLVEERERKKFWIQQLMMTALDLNNEVHDTHHPIAVSAYYTDQKPESLKKALDVRSNRIPKFLSYFERNLKWNAAATATATGGKGGGEGAKHKYLVGNSLTYADTTVWQVLDGLQFAFPKEMEARSKEFPELLGTFYNSVKEELKEYLNSSRRLKYSQGVYRYYPELDRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1QP10</accession>
    <name>N1QP10_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_130602</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016766075.1">
        <property type="nucleotide sequence ID" value="XM_016902366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QP10"/>
    <dbReference type="STRING" id="692275.N1QP10"/>
    <dbReference type="GeneID" id="27899503"/>
    <dbReference type="eggNOG" id="KOG1491">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037276_1_0_1"/>
    <dbReference type="OMA" id="WILGNLM"/>
    <dbReference type="OrthoDB" id="545683at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01899">
        <property type="entry name" value="Ygr210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.470:FF:000001">
        <property type="entry name" value="GTP-binding protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013646">
        <property type="entry name" value="YGR210-like_G4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF1">
        <property type="entry name" value="OBG-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08438">
        <property type="entry name" value="YGR210-like_G4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="5"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF17954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="437" mass="47214" checksum="14E8F15D32A00E1A" modified="2013-06-26" version="1">MPRDPLIGLVGKPSSGKSTTLNSLTDTKTAKVGNFPFTTIDPNRAIGYLQIPCACSRTSIPGNAPPTPNAPPPLSLRCKPNYGACQQGTRSVPIELLDVAGLVPGAHEGKGLGNKFLDDLRHADALIHVVDVSGTTDAEGKATRGYDPYQDIAWLRSEIVNWVLGNLMSRWGSIKRRHLAVKATAVETLQNQFSGYGSTAAVVARTLDKMGLKIPLQDWDDETVKSVVEGFIDEKFPTVLALNKIDHADADKNVAKIAKNVEAERIVLCSAISEVFLRRLVQQGFVRYIPGSEFVDTREDLLEAGEEDGGGLKEMDDKLKQRIENMKDMVLYRFGSTGVNQVLTRASELLGLTPVFPVKNISTFGTGEAGTAGGDRAAVFRDCVLVKKNTTVGDVYRKVMGDAPMAYVETVGGVRISENDIIAPGQNDIISFKVGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1QP12</accession>
    <name>N1QP12_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Coatomer subunit epsilon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_146857</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPI-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the COPE family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016766085.1">
        <property type="nucleotide sequence ID" value="XM_016903912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QP12"/>
    <dbReference type="STRING" id="692275.N1QP12"/>
    <dbReference type="GeneID" id="27901049"/>
    <dbReference type="eggNOG" id="KOG3081">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049363_1_0_1"/>
    <dbReference type="OMA" id="MIVLSQH"/>
    <dbReference type="OrthoDB" id="310217at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006822">
        <property type="entry name" value="Coatomer_esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10805">
        <property type="entry name" value="COATOMER SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10805:SF0">
        <property type="entry name" value="COATOMER SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04733">
        <property type="entry name" value="Coatomer_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016478">
        <property type="entry name" value="Coatomer_esu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR016478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF17964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="307" mass="33390" checksum="DB31F4585FDAF461" modified="2013-06-26" version="1">MDPFSSEGELVNIHTAFVQGQYQSVLNDYTVSDFSPENALPIRILQYRAQCALGQYNEVLSSLSSDNSSSSSDSPDLAAVRLYASSYLQPPSDPTILTPAEELASTASENLTVQLLISSILSRAGKPDAALQLLSSHTGSLDAVALSIQICLQQNNLERAIKEAKAARSFAQDALLVNLAEAWIAMRMGGEANYQKAFYVFEEMAQGPSSRSVVSLVQQGVSELHLGRVEEAEVALGQAWEMEEGKNYAAAVVNKLVLDVGVGREGTEELTERLKGLDKECEFLVELEEKRSAFEAAMAKYNPKFEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M3ARB2</accession>
    <name>M3ARB2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_54700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF08009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756130.1">
        <property type="nucleotide sequence ID" value="XM_016909315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3ARB2"/>
    <dbReference type="STRING" id="692275.M3ARB2"/>
    <dbReference type="GeneID" id="27906452"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_1"/>
    <dbReference type="OMA" id="NCTQEAW"/>
    <dbReference type="OrthoDB" id="294295at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005559">
        <property type="entry name" value="PRK07231.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G02870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639:SF1">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF08009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="274" mass="28977" checksum="56CD27C39576C1C6" modified="2013-05-01" version="1">MSPPSPSRTGRLTHKIAIITGGSTGLGAGIVQKFLYEGARVLIFDLHASAEQDEKEQGQQISSSLLFFKGNVTEEQDWKEALKMVLEKWGGLDVVVNNAGVVHVAAVSRETHGILCLRPAPTVPKSEYDRIMETNVTPLYHSAAIIAPYFQRQHRGVFVNISSISAPRPRPGLVWYAGSKGAVSAVTKGLAAEFAKDGIRVNAICPVAADTGMMASVLGGIDSEEGRAVITKGIPLGRVATPEDVGNAAAFLASDEASFITGIELPVDGGRALM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>M3ARQ8</accession>
    <name>M3ARQ8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_121668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF08179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756300.1">
        <property type="nucleotide sequence ID" value="XM_016901703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3ARQ8"/>
    <dbReference type="GeneID" id="27898840"/>
    <dbReference type="HOGENOM" id="CLU_987544_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF08179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="282" mass="31886" checksum="ADA662F631C9CE38" modified="2013-05-01" version="1">MTSHPVNDDGAQKRDKEDDEKGASPTPKRVEVDAWKEGCCHCAISGHQRGSLSQHGYVPLTSLKADPARRRRQVTFCQTFVPSHQNCMHCRKKSGHNSIKNSCVSSPVLFATEYPATPLGWYKMHSRQSNPDSRAQQETFHRVAQRGQGFQVVQVSQEVAVLRWDALERRQEKMEPDPRYADEVAPSFFSAASRSQPPMMSLGRERERQPRQLFTPLTVTSARSTRLARSGTSCPFTKHPPPNEASHSRHDCLSTAQNTFDAAHNLRRVAEYKLHRIAEGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M3ARU3</accession>
    <name>M3ARU3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_152469</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF08219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756340.1">
        <property type="nucleotide sequence ID" value="XM_016907464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3ARU3"/>
    <dbReference type="STRING" id="692275.M3ARU3"/>
    <dbReference type="GeneID" id="27904601"/>
    <dbReference type="eggNOG" id="KOG0757">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_6_0_1"/>
    <dbReference type="OMA" id="WVMYEQM"/>
    <dbReference type="OrthoDB" id="269120at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015218">
        <property type="term" value="F:pyrimidine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990519">
        <property type="term" value="P:pyrimidine nucleotide import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049562">
        <property type="entry name" value="SLC25A33/36-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829:SF4">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="42"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="163"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="276"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF08219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="373" mass="40226" checksum="DB2AB86E126124DE" modified="2013-05-01" version="1">MLTLPSPPTPGGPISQSRELGQIDPSTAISPASQHGRSIKDRRPWAHFIAGGAGGMTAATLTSPLDVLKTRLQSTFYQSELAARRAAKGIPPPSQMNLLRAAWLHISETGAILAAIPKVEGGKALFKGLGPNLVGVVPARAINFWAYGNGKRFYANQFFHGQDVAGAHLMAAATAGIITGTATNPIWLVKTRLQLDKEHAKGSGGRTYQNAWDCVVKTVRHEGIRGLYRGLTASYLGVSESTLQWMLYEQAKKSLGRRHDDLVRSGRTPNAWDQTVEWTGKLTAAGGAKFVAALITYPHEVVRTRLRQAPVDASGRVKYTGLWSCFTTVFKEEGMASLYGGLVPHMFRVVPSAAIMFGVYEGVLWSLGESSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M3ATP7</accession>
    <name>M3ATP7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_73145</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757005.1">
        <property type="nucleotide sequence ID" value="XM_016910014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3ATP7"/>
    <dbReference type="STRING" id="692275.M3ATP7"/>
    <dbReference type="GeneID" id="27907151"/>
    <dbReference type="eggNOG" id="ENOG502RZKF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055491_3_0_1"/>
    <dbReference type="OMA" id="YCGAVQI"/>
    <dbReference type="OrthoDB" id="428768at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF8">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="6">
        <location>
            <begin position="29"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF08884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="179" mass="19929" checksum="8502CCF9626A2FCD" modified="2013-05-01" version="1">MSSYIPKVQDGPVPLPTQGAHGEDDKKTATATCYCGTVQLEFVTEGEHFVDTFICNCTDCRKITASMFASNFIIADPGVKHLRGEDKLTRYAQRNTIKSGCEMANYFCSVCGTLMYRVGTGFPGNKVMRTGTVDDYTLHETKLKPRIEQFTKDRVAWLQGAEGVQQEKGSFYNGKEPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M3AXX4</accession>
    <name>M3AXX4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Bac_surface_Ag-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_150482</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAM50/omp85 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759716.1">
        <property type="nucleotide sequence ID" value="XM_016906206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AXX4"/>
    <dbReference type="STRING" id="692275.M3AXX4"/>
    <dbReference type="GeneID" id="27903343"/>
    <dbReference type="eggNOG" id="KOG2602">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014798_3_1_1"/>
    <dbReference type="OMA" id="SGIWRQI"/>
    <dbReference type="OrthoDB" id="1724197at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.50:FF:000008">
        <property type="entry name" value="Mitochondrial outer membrane beta-barrel protein Tob55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.50">
        <property type="entry name" value="membrane protein fhac: a member of the omp85/tpsb transporter family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000184">
        <property type="entry name" value="Bac_surfAg_D15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039910">
        <property type="entry name" value="D15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815:SF18">
        <property type="entry name" value="SORTING AND ASSEMBLY MACHINERY COMPONENT 50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815">
        <property type="entry name" value="SORTING AND ASSEMBLY MACHINERY SAMM50 PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01103">
        <property type="entry name" value="Omp85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="domain" description="Bacterial surface antigen (D15)" evidence="6">
        <location>
            <begin position="173"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF11595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="516" mass="55719" checksum="17872A5D2AB28D78" modified="2013-05-01" version="1">MASLPLEDDVFQQLRKPIDAKVLEQREKEINERIQTSYDKAEKRQHELISLNSTAPVSISSIKVLHATHTRHHFLERIFNPLLTQNRKDQAYYTLREALAEVSHAVDKLNRLDIFQSPISTYIDKAEPTDSSTTPTDYAVFVTAKERGRYTIKTGTEAGTAEGSAYVNAVLRNIFGGGERLNGHASLGTRTRETYSATFDTPILSNPDLRLEVGGLKSSTIKPWASHEEVLRGGSTKFLWRNSPFLHQELGYTGFWRQVTGLAEKASPTIRADAGDSFKSSLSHTLTYDSRDTPMLPSRGLFLKAASELAGVGPLAGDVAFGKYEVEGQAAVPIPIPGIEGDSGISFTVGLRGGFIAPLPLGGESTIKGTRINDRFQLGGPTDVRGFRLSGLGPRDGQDAVGGDVYAAGGASLLFPLPRVGADTPLRLQAFINGGRLLALRDTPGDGPRRVGDVGNSLTRTIHDLSNSLPSAAAGFGLVYAHPAARVEVNFSLPLVIRKGEEGRKGLSFGIGLNFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M3AY52</accession>
    <name>M3AY52_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_149095</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760528.1">
        <property type="nucleotide sequence ID" value="XM_016905336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AY52"/>
    <dbReference type="GeneID" id="27902473"/>
    <dbReference type="eggNOG" id="ENOG502SX24">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087045_1_0_1"/>
    <dbReference type="OMA" id="MSSHPLE"/>
    <dbReference type="OrthoDB" id="5423884at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF12407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="220" mass="24545" checksum="22E584D05A268B78" modified="2013-05-01" version="1">MPAIPFPLPSAPSLSTNTRILDSRQLRHAAYTYARSVIRTAQHAKRALLPRQSPNGVTIAIPAQYEGLNSGPAPGAVAGIILGSVAGFLLLIWLLWIASSGSGFIRATTLQEEDVMVRRRSRSRATRRSRRTEMVSRSPRRDRVVRQERIVRDIPPPRETSRLRETIIVDEAPMPERRVEGDDIVEVIEEHSSIGVPPPRRKSRRGSQGGGYRRGEFSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M3AZD5</accession>
    <name>M3AZD5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_149424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761003.1">
        <property type="nucleotide sequence ID" value="XM_016905540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AZD5"/>
    <dbReference type="STRING" id="692275.M3AZD5"/>
    <dbReference type="GeneID" id="27902677"/>
    <dbReference type="eggNOG" id="ENOG502SHAC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019189_9_1_1"/>
    <dbReference type="OMA" id="DVNRGPH"/>
    <dbReference type="OrthoDB" id="10003767at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF2">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="56"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF12882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="534" mass="61328" checksum="B87D7BD9D82849F1" modified="2013-05-01" version="1">MEYPEHLFYYTSGRWLYNEQQRMKERERVFNVNELKRLAAEAVSRKVEDVVYFDKLGEGGANRAFVLHMKDGSRLVARIPYTGTAQRQLAVASEAATMSFLRSQGVPVPQIHGYSTSADNPAGTEYIIMEYSLGTNLSDSWFEMNEQDRSKFITSLVALEARLLNIRLPANGSIYFLRDLPANVDRVAIDDDSQGLDSFYIGPSTSPNLWRGRRGGLDVNRGPFIEMEAVLTAGAKKEIAYLEHFGRPLLPYDRIRRETFQLEKQLPSVHLDSLRKYLTVAPYLVPADQHKLQKPTLRHPDLRPSNVFVSDHYEITSLVDWQHSTILPLFLHAGIPDYLNNSSDPISQSLETPKLPPNFHELEEDQRAEQRELFRARQLHYIYVAETAKQSPAHFAALVYPHSMVRRRLHRLSSDPWAGDNIPLRSSLIFLAQRWHEIVTDPTIPCPIHFTAEDAYECLALDESEREAEEQMRASMEMLGIGPEGWVPCDHYAAANEATQRMKSDCLELAETELELRAVNEHWVYDDMDEDEYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M3B044</accession>
    <name>M3B044_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_107215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="763"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF14397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="797" mass="88909" checksum="721A1ECB9F14E951" modified="2013-05-01" version="1">MSTSAPGADRISLASSWHGVSLDEWSGQLTDSTRRPREMTRSNGDHAPSVNTFVVEAAYGRRSVTLSTSGQVEVATSTDEHSDLASYSRATYETGIEDGILLAANAEVAALVSSLRMTLSIIDLRDGFIEDCQGVDSIVHSAKCFTLRARQSFVAVAYDTSVDILFQSRYEHDSALMRSWQFVRRISIVDLGVNITGLAWQADGSLAVAAGTALFIAGPQAVLDQIDSHVLESADVPEESKTVQLPVLAHHLSRHLPAWHPSTLERLVLHGHSWAAVYLLKTLASKLKFWSTGDELDHMLGADPQTLLERTDDAWLDEETANELKDQLDEKELPAILRKDQRRLSNVIDALLYLRDHHNGLDHNALWYLFTWKLQLLPHQARERQANTNTQAEIQYTHDHGFVPEMSWREIVMAYHSTSQQPLLDILILHYDNKLTWDIAKRLGIMAWLQDREALMQAFEQMAQTAYRSTSPPDPTHAAIYYLALHKKQTLAALWRIATWHREQRSTTNFLKKDFSQPDAKTAAKKNAYALMGKRRFHYAAAFFLLADNAADACNVLAGQCDDVQFAIAVARLYCSDGSEVLREVLADRILPEAKKDGDRWLMSWCHSVRLEKMQAVEILVQPIEGIVKVWQRDDPATLLLYTQLRKTPSEHEYTAVLRSAKILGRMGLAVLALDVIRSWKFTARTLPTTNGLSNGTLATLPDRTVSEPVSTPAEHAEPPSLLNGFADPAPAQSAPMDEKAAREAKAAELLAKIQAKKNAAKPKAEGEEGGKEEKDRRQPTQFKEPDANSLLDSFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M3B769</accession>
    <name>M3B769_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_147508</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the turnover of nuclear polyadenylated (pA+) RNA.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763818.1">
        <property type="nucleotide sequence ID" value="XM_016904343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B769"/>
    <dbReference type="STRING" id="692275.M3B769"/>
    <dbReference type="GeneID" id="27901480"/>
    <dbReference type="eggNOG" id="KOG2135">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017928_1_0_1"/>
    <dbReference type="OMA" id="ITYDSHA"/>
    <dbReference type="OrthoDB" id="443401at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12257">
        <property type="entry name" value="RRM1_RBM26_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.10">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045137">
        <property type="entry name" value="RBM26/27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14398">
        <property type="entry name" value="RNA RECOGNITION RRM/RNP DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14398:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN SWM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="204"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="306"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="204"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="80"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="632"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="405"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="642"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF15697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="671" mass="74319" checksum="44D1B645C35C5571" modified="2013-05-01" version="1">MKFDDADSELLKAWIISKLEKSTEVDADGDVLADYVLALLTTDESDAIARSNCVDNLKDFLNDKTDAFVSELFAAIATRSFDPSTKQPPPPPKPPAKVTIPQTPAFNQGKKRGYHAPDRVDESRLPGNGTNGRPSKQARRGATSGRHGRGNYLRPAISPPPLSGLPAWDPANPMASFMAMATAMATGLLPPGMPAMPMLPSTPMKSGNRCRDYDTKGFCTRGAQCPYDHGTDAYVVPQDDQMVEYDDGSELLAGLVPTKNGMLAYSPLDWAGQNKQKSAASKKSRGRAKKRADFSLQGPNYDQSVTSIVVEQIPKEKFDEQTVRDFFGEFGAIEDVTMMPHKRLAIIRYDSFRSASAAYNSPKSIFDNRFVKVYWYDSPDCLPELPMTGFTDEIEMGDEEPAFDIEEVRTRQDEAQRRYEERQKVLEEARQKRLEIDAKIRELEAKKGQVADELARKQGLPAESEKTRQLREQLAKLEEEAKTLGIDPDAVTIGSADWSSASFYPRGRGGYRGRGRGRGGYRGGYRGSGWAGAAKSGAVLRLDNRPKTVSVAFTEGSFDDHHEVLRSWLLFNAAEHASLDRHPDKPQAALITFEERYQCEIFMSTTLTTDFPLHGRIELSWYTGPPVTHGLLPDTTKAEDASSSVSSSSVSEADDRVDYLHDVANDDERWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M3B7F4</accession>
    <name>M3B7F4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cwf21-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_154535</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC21 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763923.1">
        <property type="nucleotide sequence ID" value="XM_016907567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B7F4"/>
    <dbReference type="STRING" id="692275.M3B7F4"/>
    <dbReference type="GeneID" id="27904704"/>
    <dbReference type="eggNOG" id="KOG1869">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067891_2_1_1"/>
    <dbReference type="OMA" id="LAHMRPR"/>
    <dbReference type="OrthoDB" id="6431331at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21372">
        <property type="entry name" value="cwf21_CWC21-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051372">
        <property type="entry name" value="CWC21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013170">
        <property type="entry name" value="mRNA_splic_Cwf21_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36562">
        <property type="entry name" value="SERINE/ARGININE REPETITIVE MATRIX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36562:SF5">
        <property type="entry name" value="SERINE_ARGININE REPETITIVE MATRIX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08312">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01115">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="CWF21" evidence="8">
        <location>
            <begin position="54"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="132"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="135"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF15802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="167" mass="19208" checksum="AC175928D71E080F" modified="2013-05-01" version="1">MSSNVGLSTPRGSGTSGFVQRNSANLRPRDDVKPYPTDIDSIRHRQRQPDKEILEHEQKREIEVKVFQLRDKLEDEGVDEDEIDDQCDALRKKLGKEQNGRGPNAKGLKSHQVHELARAKIDESEKLRKALGIGKDYEEGSHWRKQEEKKLEYQREHGGGEIGRDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M3BR03</accession>
    <name>M3BR03_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7918 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_121323</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756669.1">
        <property type="nucleotide sequence ID" value="XM_016901681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BR03"/>
    <dbReference type="STRING" id="692275.M3BR03"/>
    <dbReference type="GeneID" id="27898818"/>
    <dbReference type="eggNOG" id="ENOG502T60F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_780804_0_0_1"/>
    <dbReference type="OMA" id="HARANPQ"/>
    <dbReference type="OrthoDB" id="3364132at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057678">
        <property type="entry name" value="DUF7918"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223">
        <property type="entry name" value="BETA-LACTAMASE-TYPE TRANSPEPTIDASE FOLD DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223:SF1">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR EAF N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25534">
        <property type="entry name" value="DUF7918"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7918" evidence="2">
        <location>
            <begin position="9"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7918" evidence="2">
        <location>
            <begin position="231"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF08548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="407" mass="43663" checksum="519D808374DC2888" modified="2013-05-01" version="1">MAISELLPGLTVSIQINGRELPEYRDEDIQDPERTTSYLIEAVADSIFEIHARANPQAIFAGSSLAIQFYVDGKYVDGTLIDAEDVSETGDSAKSQGRYVSNDMLRKYQFASREQQIEIVERQSNSLSSRGRLSGRSSATPSVSYTGYKTYTGPGNTGYTARYPLEPTSAVHSEKTSFGTMTGPSYSLAASSNAAVAGNSTGAVSAGSNPPITLNSTIPLPDTNLNASTTAGAQCNDLEELGTIKVVVCHVNKKQPVDFGRSSSATSKISDNIQKAIKDKAGGLLVRFTAPQHVAPVTTWDVDPANDTGDSSVTYIYHYRTREMLEALDVIPNDARILPLPLRAKKLETVEELHEHAGGPNFAGQDDVDMQGGEDQDTDSGSRGMLSAEGEDWDVVYKDEASGTSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M3BRC0</accession>
    <name>M3BRC0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Jacalin-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_151653</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756789.1">
        <property type="nucleotide sequence ID" value="XM_016906957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BRC0"/>
    <dbReference type="GeneID" id="27904094"/>
    <dbReference type="eggNOG" id="KOG4525">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009601_2_1_1"/>
    <dbReference type="OMA" id="MFRNNFG"/>
    <dbReference type="OrthoDB" id="74460at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.30">
        <property type="entry name" value="Jacalin-like lectin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001229">
        <property type="entry name" value="Jacalin-like_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036404">
        <property type="entry name" value="Jacalin-like_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053002">
        <property type="entry name" value="Metalloproteinase_M10B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021917">
        <property type="entry name" value="Unchr_Zn-peptidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21054:SF2">
        <property type="entry name" value="MIP04191P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21054">
        <property type="entry name" value="ZINC METALLOPROTEINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01419">
        <property type="entry name" value="Jacalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12044">
        <property type="entry name" value="Metallopep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51101">
        <property type="entry name" value="Mannose-binding lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51752">
        <property type="entry name" value="JACALIN_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Jacalin-type lectin" evidence="2">
        <location>
            <begin position="667"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF08668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="806" mass="89188" checksum="647635805771E964" modified="2013-05-01" version="1">MPSFLKEHLSFRRRSRPSIRDSSSARANASASASASASVSASGSSSEASNDEPHLGRPSHALSKSSSTLNSNLENKQSPPTTLSSSKSNTNLSVYGVNGKAPPVPPRPQMPSSQSNRYSISGMPVQNGERPTPSTSPLAPRVLSVSDGSWVHQKVLLIFGQCAEPSQPIDGTITVCHHNDNFPPISWPVCDSHFKVLVHLQPGPNRLRLDFTSPKLPPTNSSIPAHSSWININYLPLNSAPPLQLCILVAKDSPGTYDAVPERVEKEGNNIPTAIRKFKMAAYLWQAFTAEQMNRNGFGRRCYRYEDEWQPGSLTWKDMETGQMRNEAKVHVIRLDKTVAEIQDLEIAQQYEPAKKKGDLYGYAMDAVREYFGPRPGQTRYVSCMFLDSHWDKQIGTVRGHAALGGGDESIKLAIFGSHCLQSYPAHLEEVVPAFSDCTRTDTNYVANDCNEGGSNWESANIGIGAHMHETGHLLGCPHQESGVMLRDYTKLNRTFLCREPYSTRTKQQGQKLCLPKDECTWHRLDTLRFRYHPTFQLPTDQVMNADRSVQVWTVDNNTVLVTAATGVAWIEIYPEGDEVCHYFVEYVEPSSGPSSAPRVVTLTEKSIQDQLPSEKRKRKINLKVFSCGGAELEVKDFSRLCSKEARIKLPDGRPGFKGSKLGFSQMDGSNPQQLILGNFHKQGKFDQKKLLMTIKVYHGDMVDGLEFFYEDGVSELFGKRGGRPGGSDFALNFQRGEMLLGFYVRAGAWIDGLQIMTTTGRRSEIYGKATGGSGHTLIPPRGYNIAGIYGSCGHWLDGFGLIISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M3BXZ8</accession>
    <name>M3BXZ8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_117474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761052.1">
        <property type="nucleotide sequence ID" value="XM_016901341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BXZ8"/>
    <dbReference type="GeneID" id="27898478"/>
    <dbReference type="HOGENOM" id="CLU_1256726_0_0_1"/>
    <dbReference type="OrthoDB" id="10605237at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF12931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="24344" checksum="B3BEC073085C44C8" modified="2013-05-01" version="1">MKGLFPTAQLGAHYLNANNNNNHHNNHIRHVPGHTPSRHHNNNQDIVMLCSKCGESIEPSGMTSRTWLAVTTNCICILLMYGAAYVVKDLEHDYRSAVSSAAGTAIKKPILISLAVFLFCAVSHLVIAHDIVGMSLRRMLFWGTNVGAAGAASAIILCTICFPHLRAGRWLMAMHFAMWGWTVALSAVYVFEALRLHRMPKKESECTEARNEKAAFVMTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M3C1L5</accession>
    <name>M3C1L5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoglycerate mutase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_147998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762322.1">
        <property type="nucleotide sequence ID" value="XM_016904638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C1L5"/>
    <dbReference type="STRING" id="692275.M3C1L5"/>
    <dbReference type="GeneID" id="27901775"/>
    <dbReference type="eggNOG" id="ENOG502QU7B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018502_1_0_1"/>
    <dbReference type="OMA" id="WDSMRAP"/>
    <dbReference type="OrthoDB" id="3898179at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051710">
        <property type="entry name" value="Phosphatase_SH3-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469:SF27">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="593"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="741"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="626"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="655"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="749"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF14201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="773" mass="84858" checksum="22B86D8656434DD6" modified="2013-05-01" version="1">MRLDAADQSWHLSTPAPYDPPLTYGGWNQCRALGTRIASLLYAREQEYNNAQTGAGDNGTNAFNPTGTRRRRKKHRVVIHTSPFLRCLQTSVAISAGMAQFEEPGDKTKSSRPRSPAQMHSGLHSPRLHAMSGSTSPSLAPIAEPKHDLAHQLARRTLAEHKRYRKAKIRVDAFLGEWLNPQYFDHITPPPPSPLMVAGAKAELMQNESVDLFTPSMSHKSSNNSLWSGNNTRQNHSRSSLDSWSHVTDALHAPTPRRDRSSSVSSVGSNESHHGYHNHSGSGRKSPFRHGHNLQPLTSTIPKPEYSVYHPPIPSYAISNSDHIPRGYVSHARNATVNVDYHWDSSRQPLDWGNGGEFGEEWSSMHRRFRRGLNNMMEWYSNHDANDRGEDSLGLEQADRPHVYHYDDEEQEDLVVIMVTHGAGSNALIGGLTSQPVLLDVGMASLTMAVRKHDAPALALQQHGGLATPDGSPCPSPNPGSMQRRRSAYDIGLSDIYEMKLVASSEHLRPGVDPTKLSATNATSHLKTAKEAMAKYDRIGGVAHAEAGSGIESNWDLGEPKVPTGPVRTNSGSANAALGSIRRPCAPVISRSISEPTDNVLPPPNLTTGLWTPPSGRGTPLPNAQRAKEEKDSVFLRFQEKSGRSSPGHDLVLDFSNSPPDSRPTSSEGPPTQPSTMVATVTSEQEERKIVDSVLGDEQSPHELADEIAKEAADEATDLPQVAKEAPMSLSRGLSVKNLWGRPQFQRTQTEDKVARSWNKAEPKRRWTVTEHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M3C1S2</accession>
    <name>M3C1S2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Actin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_148028</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the actin family. ARP1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762382.1">
        <property type="nucleotide sequence ID" value="XM_016904658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C1S2"/>
    <dbReference type="STRING" id="692275.M3C1S2"/>
    <dbReference type="GeneID" id="27901795"/>
    <dbReference type="eggNOG" id="KOG0676">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027965_0_2_1"/>
    <dbReference type="OMA" id="YTTWTGG"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10216">
        <property type="entry name" value="ASKHA_NBD_Arp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000015">
        <property type="entry name" value="Actin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000018">
        <property type="entry name" value="Actin-like protein (Centractin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF14261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="380" mass="42371" checksum="F89A14169CFEADCF" modified="2013-05-01" version="1">MGDLHNTPIVIDNGSGTIRAGYAGADAPACYFPSFVGRPKHLRVLAGGLEGDVFIGNRAQELRGLLKIRYPLEHGIVTDWDDMEKIWQHIYTDELKTLSEEHPVLLTEAPLNPRANRDTAAQILFETFNVPALYTSIQAVLSLYASGRTTGIVLDAGDGVSHAVPVYEGFAIPNSIRRIDVAGRDVTEELQRLLRKSGNVFHTSAEKEIVKSIKEKVSYVALDPRKEEKEWMNASSRGGESKAVEYVLPDGKKLKIGPERFRAAEILFEPELIGLEWPGLHQIVVDSINRTDMDLRKALFGNIVLSGGSTMIKGFGDRLLHEVQRLAVKDMRIKIFAPPERLYSTWIGGSILAGLSTFRKMYVTIDDWHENPDIIHQKFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M3C221</accession>
    <name>M3C221_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">Chitin synthase</fullName>
            <ecNumber evidence="2 11">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SEPMUDRAFT_148081</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 11">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cell membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the chitin synthase family. Class III subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2 11"/>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762462.1">
        <property type="nucleotide sequence ID" value="XM_016904689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C221"/>
    <dbReference type="STRING" id="692275.M3C221"/>
    <dbReference type="GeneID" id="27901826"/>
    <dbReference type="eggNOG" id="KOG2571">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004760_0_1_1"/>
    <dbReference type="OMA" id="WHLTYIK"/>
    <dbReference type="OrthoDB" id="26569at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF11">
        <property type="entry name" value="CHITIN SYNTHASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="573"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="628"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="661"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="711"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="745"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="844"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="883"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="13">
        <location>
            <begin position="146"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMF14341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="914" mass="101741" checksum="C9972ED85C03A2BB" modified="2013-05-01" version="1">MAYQGVGGGHGGYDLHDTPTGSAQPYHQPPHRDSDDEEVERSLLHGNPNGPFQGPFDEPHSRSGTPTSHEPKGYSLEESYAGHAPPYNGYQEYHGSGTTLDDPAYGAPDRASSPYSRSDTGSTEAWRQRQQPGAAAGVAGLKRNATRKVKLVQGAVLSADYPVPSAIQNAVQAKYRNDLESGSEEFTHLRYTAATCDPNDFTLKNGYNLRPAMYNRHTELLIAITYYNEDKTLTSRTLHGVMQNIRDIVNIKKSEFWNKGGPAWQKIVVCLVFDGIDPCDKGTLDVLATIGIYQDGIMKKDIDGKETVAHIFEYTTQLSVTANQQLIRPLDDGPSTLPPVQMMFCLKQKNSKKINSHRWLFTAFGRILNPEVCILLDAGTKPGYKALLALWEAFYNDKDLGGACGEIHALLGKGWKNLLNPLVAIQNFEYKISNILDKPLESSFGYVSVLPGAFSAYRFRAIMGRPLEQYFHGDHTLSKQLGPKGIEGMNIFKKNMFLAEDRILCFELVAKAGSKWHLTYVKASKGETDVPEGAAEFIGQRRRWLNGSFAATLYSLMHFGRMYRSGHNILRMFFLHIQLIYNIATVTLTWFSLASYYLTTTVIIDLVGTPGSSNDQRAFPFGNTVTPIFNTCVKYIYLAFLLLQFILALGNRPKGSRWTYIISFAVYALIQLYIIVDSFYLVIHAFGSGTGFVVNEGADEFIKSFVSSTGAGIIIIALAATFGLYFVASFLYLDPWHMFTSFGQYLLMMTSYINILMVYAFSNWHDVSWGTKGSDKADALPSATTQKGADGKATVIEEVDLAQADIDSQFEQTVKRALTPYIAPKEDNKKTLEDSYKSFRTRLVTFWIFTNALLAVAITSDNFDKFGFSTGATTRTANFFRALLWATAALSFIRFLGCVYFLFKSGLLSCCAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M3C2C4</accession>
    <name>M3C2C4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-histidine N-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_148117</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the methyltransferase superfamily. METTL18 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.85" evidence="3"/>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762522.1">
        <property type="nucleotide sequence ID" value="XM_016904716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C2C4"/>
    <dbReference type="STRING" id="692275.M3C2C4"/>
    <dbReference type="GeneID" id="27901853"/>
    <dbReference type="eggNOG" id="KOG2920">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038704_1_0_1"/>
    <dbReference type="OMA" id="NLLLTWH"/>
    <dbReference type="OrthoDB" id="1723750at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018064">
        <property type="term" value="F:protein-L-histidine N-tele-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF39">
        <property type="entry name" value="HISTIDINE PROTEIN METHYLTRANSFERASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="202"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="316"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF14401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="393" mass="41648" checksum="8D690B5898484E54" modified="2013-05-01" version="1">MAFSFGFSEDIASDDDSPVVPVPATVHSVPSPVATSQVPVRSHTLDDLLATLPEHLSYSTVRIESPLGKIVYLPRRELFDVRAQLLQENSSASDQVVENLDKSDLRSGIYEGGFKTWECSIDLASFLLDRGPRKDIDELVKCDQILELGAGSALPSLILFRHAVLHSLSDLTFTLADYNEEVLRLITLPNLILTWAAATTTTTTTSPESNSNSNNSMNFPLSEPSNGDFELTPSLLSNFKTSLQSTNLTLNFLSGPWSPALANLILPSASPSPSPSPSFSIGEKSLLILASETIYSPTSTAAFVDLVTTLLKRRGSGGSGSGSGSGSGSGSGGNMGKAVLGAKKMYFGVGGSVDGLKEMCRDRGAVAYEVENSGVKGMEGDGVGRALVEIQMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M3C827</accession>
    <name>M3C827_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_112089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF08045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756166.1">
        <property type="nucleotide sequence ID" value="XM_016900955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C827"/>
    <dbReference type="GeneID" id="27898092"/>
    <dbReference type="HOGENOM" id="CLU_1571618_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF08045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="170" mass="18836" checksum="BE522362BE2CAB71" modified="2013-05-01" version="1">MSVIHADRRRNSSPRKKSSTIKTYLLAKPKKKNSTPTPTSSVVPRKCKKMKMYTRCGLDPGFEPGTSRKFVLRHTLQGKALGEVWAFGKNGHGWNVHVGSIHLLRSMEVPGLAEKQYAAALHACALAKLLSDDLAASPARSRYMHPQAPRRKMDDDAPSRRSITDCARTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>M3C918</accession>
    <name>M3C918_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_152044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756476.1">
        <property type="nucleotide sequence ID" value="XM_016907210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C918"/>
    <dbReference type="GeneID" id="27904347"/>
    <dbReference type="HOGENOM" id="CLU_2307824_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF08355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="100" mass="10963" checksum="4026C6C506F0BF08" modified="2013-05-01" version="1">MRAGGGVRIGSDGGSSHHHPATRTQLREHANPTHRNIISPPFAERKPGRTEHLRARKNDFDGGTIPDNCYRRSRRCHATGDEAARKPLGISGLASTFRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M3CAC0</accession>
    <name>M3CAC0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_92949</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756921.1">
        <property type="nucleotide sequence ID" value="XM_016910600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CAC0"/>
    <dbReference type="STRING" id="692275.M3CAC0"/>
    <dbReference type="GeneID" id="27907737"/>
    <dbReference type="eggNOG" id="ENOG502SMIC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_3_0_1"/>
    <dbReference type="OMA" id="NLDMRRV"/>
    <dbReference type="OrthoDB" id="5417887at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF147">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="36"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF08800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="351" mass="40184" checksum="AAC272A6E7DC0A6F" modified="2013-05-01" version="1" fragment="single">MDDFGKNLNIHYVNPNKQLYAGIWSLYTGATAFLIARLWVKISRRHGLWWDDYILLFAWGVLTANDIIITIEYATGYVSPSWDDRMHILILISSCGTLMGQSLTKVAFAVTLLKLTKGFSCWKVCHWILWFCIATMCSYNFAKIIVEWGKVCDNRGYDVWYRMDFCVYSEPRARFKEGGNYVNVVMDFVFAAFPWIITWNLDMRRKEKIGLCLTMSLGLVVAIASAIRTEWKYDGNRKDEWYFWNNAMSNIWYSSEVTGTIIVQCVPVLRPLLKHISTTMRSKRLGSSTDDGGTFGLSKLDGHVGRWYPPSRLKDEGGLIPGPVGDEETLILSVRNGIVARKDMNGDRVHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M3CBL2</accession>
    <name>M3CBL2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cloroperoxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_143621</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF09817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757938.1">
        <property type="nucleotide sequence ID" value="XM_016903051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CBL2"/>
    <dbReference type="GeneID" id="27900188"/>
    <dbReference type="eggNOG" id="ENOG502S6CG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029871_5_0_1"/>
    <dbReference type="OMA" id="DYDNIAP"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF15">
        <property type="entry name" value="HEME HALOPEROXIDASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 11" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032304" evidence="9">
        <location>
            <begin position="17"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="10">
        <location>
            <begin position="92"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF09817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="408" mass="44575" checksum="C6DF5DF5531D0750" modified="2013-05-01" version="1">MKSFVALSLLSAGVNAFPWVAHAPGVDSSALHSVEKRQQAPQPGGPGSAETCPFNAQHVDAVPVKQGQYNNARGGRKGNEKGGYQVPRPDDLDHQFIAPRPGIDIRGPCPGLNVAANHGFLARDGVTTFNELVDAQQNVYNVGYDLSLLLAFLGLQADGDLVTTKLSIGCDATTRTSINPALTGSQPGLAGHNKFEADTSLTRNDFFTGGGDNFSFNRTLFDMMSRSTGGLHNVENLAKYRGERWDQSVLENNNFFFGPLSLLLFGAASFLYELMPSGPNYIPDQETMNSFFIRERLPENWINRVEPYTNRLVTREILKMYLLNPRPFGANTADGGFTGLNWRQIQNGKLELSVEAPETLCLLYQLATQVQPSTLNGVITPTVEALSFFLTRVGPEFDNLGCARPLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M3CC98</accession>
    <name>M3CC98_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_151072</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758123.1">
        <property type="nucleotide sequence ID" value="XM_016906578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CC98"/>
    <dbReference type="GeneID" id="27903715"/>
    <dbReference type="eggNOG" id="ENOG502S04M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035511_0_0_1"/>
    <dbReference type="OMA" id="HEMLPCP"/>
    <dbReference type="OrthoDB" id="2392789at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046921">
        <property type="term" value="F:alpha-(1-&gt;6)-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13132">
        <property type="entry name" value="ALPHA- 1,6 -FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13132:SF29">
        <property type="entry name" value="ALPHA-(1,6)-FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF10002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="585" mass="64203" checksum="40E42ADEDC2BF6FD" modified="2013-05-01" version="1">MRPRRNTVLSTSPSMSSADSITSSPIASSNESIHEKTFDGFPDSPTLPLPATTKENWTKPRRDKAMVVKTLLAVCGVVMLWQYLSMSSWLHSHNASASASASVRTESQSRTQADMEWIAANALPDEPTALVVADPVGTSRWTISIPHNYTFPLPTHYYKDMCSQGDTMRAGLSVDSGYSHAKHWWQRSGYFATDPTYLDIKEAEDLGALPKSKGDSSNVCERSMTFVLDDKEASFGKTLLLLWMSYGLAQEEGRSFFIDDSTWAWGKFSAYFRPPPAPQCARPPPHQIVPCPHSARHVAVSSTTARWTFGRSFEKEFRATHKHGLASQRRIFDLARAGYKALFVLTGEDALYAASRIAKLQDDATAHHGSLVGMQIRRGDLHPFEYEYNGDYLPLERYAAAARSLLQSGHDTAAASGLNDPEHIGSPLVLASDDPRILDAAELQQAAAPFTVQRAQERIQLATKDVLDQSSPKTPERAPGSAYVKHVDENTGWEGGFFSGLFFSLGGGGSSGSNPADDQRMQLRHLVGRAYLLDFAVLGASDGVVCAISSATCRAVAVMMGWDAVREGKWLNVDDKRSWSWNGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M3CEM4</accession>
    <name>M3CEM4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome b5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_142943</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759617.1">
        <property type="nucleotide sequence ID" value="XM_016903020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CEM4"/>
    <dbReference type="STRING" id="692275.M3CEM4"/>
    <dbReference type="GeneID" id="27900157"/>
    <dbReference type="eggNOG" id="KOG1110">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042860_1_1_1"/>
    <dbReference type="OMA" id="ANEWETQ"/>
    <dbReference type="OrthoDB" id="547796at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000003">
        <property type="entry name" value="membrane-associated progesterone receptor component 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF72">
        <property type="entry name" value="NEUDESIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="8">
        <location>
            <begin position="53"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF11496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="166" mass="17986" checksum="707EBE718D6133AC" modified="2013-05-01" version="1">MADPPVGGAASIATPINLILLSLFLVLVYMRLRPNKTAPTLPAAPPPTVFKVFTPPQLEPFNGNNGMPIYFAVKGKVFDVSSGRNFYGPGGPYQNFAGRDASRGLACGSFDPDMLTEDLHGPLDKLEDLGAEEMEALRGWEERFNEKYLVVGKLVPVGHPEAEPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M3CFL1</accession>
    <name>M3CFL1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Phosphoribosylaminoimidazole carboxylase</fullName>
            <ecNumber evidence="4 11">4.1.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SEPMUDRAFT_149234</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + H(+) = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + CO2</text>
            <dbReference type="Rhea" id="RHEA:10792"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="EC" id="4.1.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">In the C-terminal section; belongs to the AIR carboxylase family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.21" evidence="4 11"/>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760734.1">
        <property type="nucleotide sequence ID" value="XM_016905431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CFL1"/>
    <dbReference type="STRING" id="692275.M3CFL1"/>
    <dbReference type="GeneID" id="27902568"/>
    <dbReference type="eggNOG" id="KOG2835">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011534_2_1_1"/>
    <dbReference type="OMA" id="ITFDHEH"/>
    <dbReference type="OrthoDB" id="15425at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004638">
        <property type="term" value="F:phosphoribosylaminoimidazole carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000037">
        <property type="entry name" value="Phosphoribosylaminoimidazole carboxylase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01929">
        <property type="entry name" value="PurE_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01928">
        <property type="entry name" value="PurK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016301">
        <property type="entry name" value="Ade2_fungi/plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003135">
        <property type="entry name" value="ATP-grasp_carboxylate-amine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033747">
        <property type="entry name" value="PurE_ClassI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005875">
        <property type="entry name" value="PurK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040686">
        <property type="entry name" value="PurK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054350">
        <property type="entry name" value="PurT/PurK_preATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004679">
        <property type="entry name" value="PRK06019.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01162">
        <property type="entry name" value="purE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01161">
        <property type="entry name" value="purK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11609:SF5">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11609">
        <property type="entry name" value="PURINE BIOSYNTHESIS PROTEIN 6/7, PUR6/7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02222">
        <property type="entry name" value="ATP-grasp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17769">
        <property type="entry name" value="PurK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22660">
        <property type="entry name" value="RS_preATP-grasp-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001340">
        <property type="entry name" value="AIR_carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52255">
        <property type="entry name" value="N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="14">
        <location>
            <begin position="108"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="391"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMF12613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="576" mass="62692" checksum="43EA86C88CB77DE3" modified="2013-05-01" version="1">MASDKTVGVLGGGQLGRMLAEAANLLEIKVNFLDAVGSSAKQVSGHNGHVEGSFKDRTAIQKLADQSDIITVEIEHVDTKMLEEISEKVDVQPSWKTLRMIQDKYLQKQHLEKYGIASMQSLALSEPTVPELERVSGELGLPLMLKSRRDAYDGRGNFAVKTTADFTAALEALAVNRDLYAEAWCNFRMELAVMVVKTETGVLSFPTVETIHENSICKLTYAPARGVSPEVNQQAQDLAKQAVACFWGKGVFGVEMFLTTSGKLLINEIAPRPHNSGHYTIEACPVSQYEAHLRAILDLPLHQEDLELREPSIMLNILGGDAPDSHLTIARAALQQRRTKIHLYGKGQARKGRKMGHLTVCAPTMREAEQLVQPMIDLVDQGKPRAAQSSRSHEEEEKKKKQEAPLVAIVMGSDSDLPVLRPGLAILTKFGIPYTVRITSAHRTPSWMAQFASSASSSSIKVIIAAAGGAAHLPGMTAAYTPLPVIGVPVKPSIGDGMDSLLSICNMPRGVPVATVSINNSVNAALLAARILGAADKGIRQVVEKYMRDSEKEVRVKDERLHEVGAEVYAERYLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M3CJ11</accession>
    <name>M3CJ11_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SEPMUDRAFT_84970</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in the control of the SAPK-dependent transcriptional response to peroxide stress. Regulates sty1 activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761909.1">
        <property type="nucleotide sequence ID" value="XM_016910370.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.M3CJ11"/>
    <dbReference type="GeneID" id="27907507"/>
    <dbReference type="eggNOG" id="KOG0519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_5_1"/>
    <dbReference type="OMA" id="EIEKWFG"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009365">
        <property type="term" value="C:protein histidine kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900745">
        <property type="term" value="P:positive regulation of p38MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000010">
        <property type="entry name" value="Sensor histidine kinase RcsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000099">
        <property type="entry name" value="Sensory box sensor histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000002">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 12" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="PAC" evidence="16">
        <location>
            <begin position="635"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="14">
        <location>
            <begin position="857"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="15">
        <location>
            <begin position="1165"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="48"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="220"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="325"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1110"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1308"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1429"/>
            <end position="1488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="325"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="378"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1110"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1314"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="12">
        <location>
            <position position="1219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMF13788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1488" mass="164244" checksum="36FE1FC8240EDA49" modified="2013-05-01" version="1">MGDRDPTPVAASRTGRKRSATNEAEYVTEELGRSTMARVSFDDFQTRVAASETGSNNSSATNEHDSPATQDDYFSAPGTDDGFNDDIVSQGSISSRRAVDLHIQIPPAQLHSHMAFTALQYLPMPVLVLSSAKTVVLANEAMGHLLGITLDLPPPDNVDLPMDHLQRVVSREASSSTDVLYGVTPGDLGLDILQNGAPMFVSWDSFLNSVLDDASHAQSSTTQLNTYREKRGDVDNTPTGRGTHHRRSTSEATPPIAVSGVRTEVHDAVVQVVFSTRRDPRTGLPLPVSANTADDEHIHSEMIISIWATEDEQYFTLTFTAAAAAPAGTSGSGGTPSEPTKTTSRTVSRAATSYSNSVHSGSGVDSGPSSNSSSRNTGVHRHHHARSKPTSVYASPLSMEFPPRGPPTQSAPHAPSLFAKTNRLKQALLNSMSMPAYAMWKDETFGIPNKAAIRLILPNAEDGEFDAQEQAKEFLLRFVLYKEDFSETIPLENYPIMRVMKTRAGFQGYRVGMYSAKDGSRMLYDTSGETLLDDKGDFVGGCVIFHDVTGYARTIMHQKEENERQFENICNMIPQLIWRTTPDGMHDYFNDPWYTYTGLSVEESEGDGWLNAFAPEDLAIAEPIWAHCLATGDEYRVEYRAKSATGDLRWMLGRATPMRDANGQIIKWFGTCTDIHDLVLAREEAKQTRLQLERVIEHANITLWAVDKDMKLTLSEGRAMSDDPADIDIHKRRNTYIGKPTSWLFERQGRESEREVFERPIRAILARQKSEETIETVTGGNGRYYRTKLLALTRQERAGGIEGETYVDGVVGVSMDVTELKKAADEVQARDRENARLMAQSVAAKEASKMKSQFLANMSHEIRTPIAGVIGMSELLLDEDDSASGKLTKEQRECAENIQRSANGLLTVINDILDFSKVESGRLDIEEVQFDLSVVISDVNKMLSFAAERKGLKYIDDIQQLSSWKVMGDPGRLRQVMTNLLTNSIKFTSDGSVTMRVKAQRETNDTVEVHFTVEDTGIGIEEEVRQRLFKPFSQADSSTARRFGGTGLGLTISKNLVELMRGEIFLESKLGVGTRATFWIPFNKAPYQTSADSPLVDLGTIPDRLASELSVSRPSSDHNGTSGPATPTGGHRKELSMGGLAGLGPWAESMGMDLDLSEEERRNTQVLVVEDNPVNQQIALKTIKKLGFPVRAVWNGQEALEYLSSPSPERPRPQVILMDVQMPIMDGYRATWTIRNDKAFVQNADVQSAPIIAMTASAIQGDREKCQAAGMDDYLAKPVKKPMLEKMLIKWAIEGRKKRVELKSNPNLLKRPGVQQNHSFTASETSSSLVTPQEHLSSEVDRLEFVHSARFASSSETESERAHRQIKAEEQAMSLRDHELIESGEDPKTKLGKGVGEEAQQITNANTGASALTEANMEQFDLRDRMGLLKRENTDGDNSSMMATLADTEGQALPSHLHQRSTAPSPERLPGSIGGPLPHRRSWQPEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M3CMK3</accession>
    <name>M3CMK3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8004 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_147027</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763159.1">
        <property type="nucleotide sequence ID" value="XM_016904040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CMK3"/>
    <dbReference type="STRING" id="692275.M3CMK3"/>
    <dbReference type="GeneID" id="27901177"/>
    <dbReference type="eggNOG" id="ENOG502QUVC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005053_2_1_1"/>
    <dbReference type="OMA" id="WIAGLDQ"/>
    <dbReference type="OrthoDB" id="5300331at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058317">
        <property type="entry name" value="DUF8004"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39601">
        <property type="entry name" value="CHORIOGENIN HMINOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39601:SF2">
        <property type="entry name" value="CHORIOGENIN HMINOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26013">
        <property type="entry name" value="DUF8004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8004" evidence="2">
        <location>
            <begin position="393"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="801"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="850"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="825"/>
            <end position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF15038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="904" mass="99106" checksum="221AD55F21DD0E5E" modified="2013-05-01" version="1">MSRRLSAIFTNNFSSSSDDRKNGSPTTGLSPRRASPPDAARSRSPSKLSKQAPSYNQARRPSAHLLPPNAGEPTLPSLQSLQDDFAVNGSDSDLMPPPSIHTASHSRTNSAGSRPGTPGGLSSSRPMTPVLQLPGQPPIHAEPAHDKKKSKHWWTKKDDKSEVARGPVAWISGHPQKVPYDVDALANAQPMQEMWNTEDGNCFVYLFPRTSGKGASFRIDSAVFASSPILTKLAFGDIYSNQSPAGGDRRAMPLEDRTSHLSLGDPATPPMTPTRKPAPGTTHGSSTTSSHDSRGRDYNFSDPQEVHLYLPIKLSSDGAAPGATNSTDGKANREDLQTLIDYRNFFAFLCGQSLVATERRSSFFAIFMTVAGILKSYQFTNVDGSTYGEAANSSFDAYIEELGLGDCRTSREKTIEGVVLGERMKSVSLYNEAFTHASGKHQDLLALKSPKFNMISPITQNRLTRASMDLDKRVAAIRLIMTDFDFPFLFSGIMASKTSIERKEGVRFDAWKEHFMGMRKFMMGMLKQRYGDWPPKASSKKNTLETSGLNRLVLRDVYQDLSSMYDLLVDRSNLTSRTIDGVNLDESRDEPVVRGLRAVLSEYDRSTPPVKPPIPFDLPKLPTLRSTRPDFGVDAKKDAKVLHKKLKDDEIHQILRASWNEDAQVTPFVDAFREMEKRAAHGCTASELEDFRIGQWIFMYTVLQALPMLACDAPGLKWTKGVEYFLCEPPRSGVPWADPNAAGARAGSRTWFSVGGAGGGVVSLPSDLIDHGVEGIYKRSHCWIMAERWCAANPLLSAALQEQQASHEPGYNDEGLPAPPSGNDLLRPSSRVSNRSNRLSSLGLGLEALPLPAGVSPDGRSPSPGIPMERPRTPVHSVDASKTFDAILGGPDMTTKSKKDRKWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M3CNS9</accession>
    <name>M3CNS9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Defective in cullin neddylation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_147310</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763539.1">
        <property type="nucleotide sequence ID" value="XM_016904219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CNS9"/>
    <dbReference type="STRING" id="692275.M3CNS9"/>
    <dbReference type="GeneID" id="27901356"/>
    <dbReference type="eggNOG" id="KOG3077">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047042_1_0_1"/>
    <dbReference type="OMA" id="LWCKFLQ"/>
    <dbReference type="OrthoDB" id="27198at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032182">
        <property type="term" value="F:ubiquitin-like protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.200">
        <property type="entry name" value="Cullin, PONY binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014764">
        <property type="entry name" value="DCN-prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042460">
        <property type="entry name" value="DCN1-like_PONY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005176">
        <property type="entry name" value="PONY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281:SF31">
        <property type="entry name" value="DCN1-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281">
        <property type="entry name" value="RP42 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03556">
        <property type="entry name" value="Cullin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51229">
        <property type="entry name" value="DCUN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DCUN1" evidence="3">
        <location>
            <begin position="56"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU410713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF15418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="275" mass="31175" checksum="F785C733F5C946C7" modified="2013-05-01" version="1">MPPALNSAQRAALNEFTSVTQADRTTGTKLLKQSNWNVGAAVNIFFNNPAGGRVNPLQDTLNKLFDQYRDVGTSDSPDEIGMDGTFKLCEDLQVSLEDVGALVLFEIVQSPSLGIIVRENWIDGWSDVGADSAAKMRNVVLQRRSALPTDQELFKNVYNHTFTLNLAERQKALMPDMAVAMWELLFKAPGLEWKTTNAAWLEWWIEYNQDKVKKAVNKDLWKQTLNFALQTLKDESLSFWSEESSWPSVIDEFVEWVKTEKWKGEKMTGDAMDQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M3CVI8</accession>
    <name>M3CVI8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyltransferase family 17 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_28745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF08172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756293.1">
        <property type="nucleotide sequence ID" value="XM_016908444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CVI8"/>
    <dbReference type="STRING" id="692275.M3CVI8"/>
    <dbReference type="GeneID" id="27905581"/>
    <dbReference type="eggNOG" id="ENOG502QPVW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038606_1_0_1"/>
    <dbReference type="OMA" id="RYHDKMI"/>
    <dbReference type="OrthoDB" id="6474464at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003830">
        <property type="term" value="F:beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006813">
        <property type="entry name" value="Glyco_trans_17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12224:SF0">
        <property type="entry name" value="BETA-1,4-MANNOSYL-GLYCOPROTEIN 4-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12224">
        <property type="entry name" value="BETA-1,4-MANNOSYL-GLYCOPROTEIN BETA-1,4-N-ACETYLGLUCOSAMINYL-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04724">
        <property type="entry name" value="Glyco_transf_17"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF08172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="309" mass="37111" checksum="451DC90CD105E049" modified="2013-05-01" version="1" fragment="single">CKSVGFTPYGEQRKVYDLIMFSTELDWLEIRLHTLDPFVDFFVIIESPTTFTGADKPLILREHWDRFLPFWHKIIYREIHDPLTSMRTWDHEDYLRNSLLYAIFPDLKGEEMPYRGDVLIVSDMDELLRPETMLLLRHCNFPARLTLRSQFFYYSFQYRHRGEQWAHPQATIYGGSVENTVAPNDLRMDLIGPGLLQYPYRYFRRFWDRGTLWNAGWHCSSCFSTIAEFQMKMHSFSHQSWNTEYNRLPETIAERVKNGEDLFGRPGEEYEKIEKNEDLPSYVLQQFRELGRFRYMVDRSDSHAGFEDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M3CWB2</accession>
    <name>M3CWB2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cell division control protein 42</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_152284</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF07951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756072.1">
        <property type="nucleotide sequence ID" value="XM_016907351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CWB2"/>
    <dbReference type="STRING" id="692275.M3CWB2"/>
    <dbReference type="GeneID" id="27904488"/>
    <dbReference type="eggNOG" id="KOG0393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_21_3_1"/>
    <dbReference type="OMA" id="PFCDVFL"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000088">
        <property type="entry name" value="Ras-related C3 botulinum toxin substrate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0636">Prenylation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF07951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="198" mass="22063" checksum="FE193C82F85A7333" modified="2013-05-01" version="1">MAAPATQSLKCVVTGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSASVMVDNKPISLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSIVSPSSFDNVKAKWYPEIEHHAPGVPIILVGTKLDLRDDPEVREQLRQRKMTPIQYEQAVNVAKDIKAVKYLECSALTQRNLKSVFDEAIKAVINPRPPQKVKKSKCTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M3CWH5</accession>
    <name>M3CWH5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_152328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF08021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756142.1">
        <property type="nucleotide sequence ID" value="XM_016907379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CWH5"/>
    <dbReference type="STRING" id="692275.M3CWH5"/>
    <dbReference type="GeneID" id="27904516"/>
    <dbReference type="eggNOG" id="KOG1812">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_470094_0_0_1"/>
    <dbReference type="OrthoDB" id="9977870at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF08021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="597" mass="67949" checksum="EAB4FAA687E1B21C" modified="2013-05-01" version="1">MLDHDRAFLLEVMKVDTQTEHELDEQLKTEAKQLGVDIEETDSAMGSNQSFRTCCSDYSRRSESVDSTTSHSTGLMSTFSDSSKEHPGISVDRKVRSGTTLSFKDYDSFVSRGVPNGRFSISFFSPPPPLPSSPFHSVFSLPLSQPPASPDASPRRHFRRIRGLSLLRPHRSDSITSLADACPHCPHDPPSQRRAIHKLPCGHRLCTQALRNTINAAIDCTKGAVPSCCSQPIPGRLVEHVMTHEEQAALLHKLEQWDEVVSSRPSTNGSHREFHQQQPPGKHHVERDHPSVMPVSLQAAQEALGDVVEREDYRLLQSSQIEQRDRYIAWAAKQQAELIDRHDQRRRDLRSMHEAVAEAMQERHASATSDAEDKQVQAESDLREAQEKERCDIATALKHLGSYCAGTYSNGESHDRIVTEQARLELKKARWHQDTMAIRHESAINVLRGEQTRRLHNRALRQDRDLHELRRQQRKEELELERSCNGELAKLNESLDEKRRKLCWRQELQMAIIAKRIEAETGTQLECRLPTADWQWDLMDSRERADSRLDGAGGLSHHPRHDSTRSETDAVLHEPDAKYDRQSTGIMHVREFKIGGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M3CXB8</accession>
    <name>M3CXB8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_151698</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756873.1">
        <property type="nucleotide sequence ID" value="XM_016906986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CXB8"/>
    <dbReference type="STRING" id="692275.M3CXB8"/>
    <dbReference type="GeneID" id="27904123"/>
    <dbReference type="eggNOG" id="KOG2190">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022670_4_0_1"/>
    <dbReference type="OMA" id="MQVVPYS"/>
    <dbReference type="OrthoDB" id="1937934at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22439">
        <property type="entry name" value="KH-I_PCBP_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22455">
        <property type="entry name" value="KH-I_Rnc1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22456">
        <property type="entry name" value="KH-I_Rnc1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="150"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="233"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="436"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="318"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="322"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="332"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="400"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="428"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF08752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="518" mass="54264" checksum="E6F6228B3B4CA600" modified="2013-05-01" version="1">MAETPHELPAHTQKRPLEEPSSPSAPTDQPDAKRPALDKMLSEEVAPLDEPADAATDVAPEEPVVGEVNDAGVEPEADAAETAEVNPEVEVTDKQGDTVVPDAPTNGGVLVDGSSAAPVAVIPDQAHNGPVDTRATPQGAQSYHQQDESQWLHVRAIISSAEAATVIGKGGENVSQIRKLAGAKCTVSEYTRGAVERVLTVSGQVDAVAKAFGLIIRTLNQEPLEEPSTPQSKTYPLRLLIPHILIGSIIGKQGVRIREIQEASGARLNASESCLPLSTERSLVVLGVADAVHIATYYVGSTLVEQLTDRFGGPAASNYAGRHGGPQGVVPGGMQVVPYVPQNTGGQVGQPDNNRRHNGPPSRGPPVPYGAPSMHGQSPYPQQPVAPVHYGAGSPRAPYAGAGPHQAHPYGHAAPQPGPGHAGPPQQPVQGVGPGQPITQQIFIPNDMVGAIIGKGGAKINEIRQLSGSVIKINEPQDNNNERLVTITGTQECNQMALYMLYSRLGESSKNSNSIMPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>M3CYA4</accession>
    <name>M3CYA4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_111524</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF09052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757173.1">
        <property type="nucleotide sequence ID" value="XM_016900920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CYA4"/>
    <dbReference type="GeneID" id="27898057"/>
    <dbReference type="HOGENOM" id="CLU_1372964_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032692" evidence="2">
        <location>
            <begin position="25"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF09052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="199" mass="20830" checksum="2BE997B8FB063785" modified="2013-05-01" version="1">MTPIIPQLLATSLGLHLLTASVLAQQQQEQQQQQEYAQTTLPPIPIETPNPNPDQIVVCAPLENQEQAQENQSDNDIPQPTLLNNSLCSTYAALTSFSSLPSNEIFTGILTASETRFTTTAAAITTMMPGTNTTTLTGTATRTKESGSKASATEGGNSGQQQGSGAQRQQGVSSAMMVWERVLVAVVLGGVVAGGMVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M3CYG8</accession>
    <name>M3CYG8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Abhydrolase_3-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_151684</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756847.1">
        <property type="nucleotide sequence ID" value="XM_016906978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CYG8"/>
    <dbReference type="STRING" id="692275.M3CYG8"/>
    <dbReference type="GeneID" id="27904115"/>
    <dbReference type="eggNOG" id="KOG1515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_6_3_1"/>
    <dbReference type="OMA" id="CVGYPEM"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="97"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF08726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="336" mass="36631" checksum="9C55772678C123F8" modified="2013-05-01" version="1">MAYSDSSKWPMLADMDPEYQKYLETAPPGPPAADDPSKIPGMRPMMKQMQLKAPYQQIDRTGVTEEQISIPARDGYQIPAVLYKPASSSAGPGPLAVLFHGGGFILGFPEMEGPAAVGLVQGHGASVISVDYRLAPEHVFPKPIEDGWDALKWASSNASTLHADLSKGFVVGGSSAGANIAAVLSHLARDQKLSPPLTGIFLNYPITVGNEVVPEAMKKDYQSFEQNANAKGLINKDAIQRIMSVYNPDQKSPLYSPMLSKHEGLPKTWLHACGLDPLRDDTLLYERELKKAGVDTRVIVSPGVPHAFETTVAHLQVAEKFREERKKAFAWLLETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M3CYM0</accession>
    <name>M3CYM0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_110210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF09754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="139" mass="14809" checksum="2683805135358FB8" modified="2013-05-01" version="1">MCALAIAVDVDLFGHLARRSPGAVPMLQLAAATGVEAQSLDTIAQTLAADGWLVHVEPNSFAANKVTHAMTDPDFQSLVAHCFEMGLPAVLATPRFLSNIDYKASQDSFLLAWQVSQATSLGFFDYLNQPGGQRPTSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
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        <lineage>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="213"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="170"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="218"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
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            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="373"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF10978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="450" mass="49319" checksum="7709D7753D1BC2EF" modified="2013-05-01" version="1">MSTQHSADGVALTPPPSTQVPPSNRSKTRTPTPPVSHISTPPPTGELPELSQTSSRLGGFASDMSEMELVKATPEELRTKVTELYAVVQEVKMSAAHHKLQYQMLAQSSAAQMERMSVEARMAQSENEVIHVADQARLAATPTTEDGFIPIHKGLYQHMCRDIQLLRDANVKLESENKKQRAILLQQEQEIASLTDKAALMAERIRANRESLQKYRRSQLSSHVEQQNTRSPYGASHRAAPLSRAHSQSQPFAALLQASEMASQESARAVKKGHTRNTHSMSSLPATPQRTQGLRHPPPFQTPRTQHQALQVPATAPQQRTNAMRTPDVYRQPSIPLPPRSPQSDGTVSASDDDAGGSEAETEIIDDDEVPESQASMIASQMLRTSQEDMEEKRESLAGRGMLDSSSNLRQTKLLGAIRKPNVRRGEDGPPAKRARTSPSIGLGISTARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M3D1F7</accession>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032760" evidence="1">
        <location>
            <begin position="33"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF10318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="392" mass="44993" checksum="0E907A0E3A0C8E41" modified="2013-05-01" version="1">MNMTLSGRDARWRFSNITVLLVMLASCSKTSASSLPALGIRPFVQVRPDDHAHHRRPQIGPLAKRITDDEIRAEWAARGCKLIAYMEEGNMQPLYRTMKSDGVLSPAQLRLRTSQSVFTNYDELASNGWTRNPERRLADRLNFVESHADVAILDVFADLQISASVRTRNNPNGDNELVAWEQDQDFYNGARGESTRASYTIIYNTLNGIIIRQFIKSPQKMRDTVYGDGDGDEKDWRNIPGLQLPHLRLVSDVASLEYAALCQKFHHRPMSFRYSIDFDVENSDTNKIIHLVLERRGYTEMDSQGVYLVARPWSRRLIIDRTNPSDWEDFQSLVGSPNVRGTAWMLIQHSRLFGHKRIRRIAIWKPEDEYYRLPCILVEVEDVPIVSSLGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2022-12-14" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>M3D1F9</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
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        <name evidence="1" type="ORF">SEPMUDRAFT_150292</name>
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    <organism evidence="1 2">
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        <lineage>
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            <taxon>Dothideomycetidae</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016906071.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="27903208"/>
    <dbReference type="HOGENOM" id="CLU_2924192_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF11328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="61" mass="6944" checksum="4146F3E3292B9402" modified="2013-05-01" version="1">MSSSPIHLDELESTRVGVNCGCVDRFFRWSQSDERHNERVCVERPTCACNSEPTTSKRDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M3D3G1</accession>
    <name>M3D3G1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_45057</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
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        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760886.1">
        <property type="nucleotide sequence ID" value="XM_016908947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D3G1"/>
    <dbReference type="STRING" id="692275.M3D3G1"/>
    <dbReference type="GeneID" id="27906084"/>
    <dbReference type="eggNOG" id="ENOG502SQ3E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097994_0_0_1"/>
    <dbReference type="OMA" id="QRDFMSN"/>
    <dbReference type="OrthoDB" id="3598904at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF12">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF12765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="185" mass="20900" checksum="694FBA60D7739383" modified="2013-05-01" version="1">MRFMQGFHPTAPRDHIAVTMAEKYLRYAPWFSQWEQAFTAFLSDQRDFMSNMDLKRAMVLKANHLVGTMLASVDQSAGPVAYDAYEAEFRAIVDLAREVLASFSCPPLPTLSGPNSGTPYLSFSLWVTDPLWMAISRCRNPTIRQSAFTLLSRNPRQEGIWHAGPQLPSSSQYMRRVESTSTGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M3D430</accession>
    <name>M3D430_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ppx-GppA-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_156512</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761061.1">
        <property type="nucleotide sequence ID" value="XM_016907679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D430"/>
    <dbReference type="STRING" id="692275.M3D430"/>
    <dbReference type="GeneID" id="27904816"/>
    <dbReference type="eggNOG" id="ENOG502QRXN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033165_0_0_1"/>
    <dbReference type="OMA" id="GWGYMLM"/>
    <dbReference type="OrthoDB" id="2014654at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000191">
        <property type="entry name" value="Retrograde regulation protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050273">
        <property type="entry name" value="GppA/Ppx_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003695">
        <property type="entry name" value="Ppx_GppA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057512">
        <property type="entry name" value="RTG2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30005">
        <property type="entry name" value="EXOPOLYPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30005:SF0">
        <property type="entry name" value="RETROGRADE REGULATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02541">
        <property type="entry name" value="Ppx-GppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23566">
        <property type="entry name" value="RTG2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ppx/GppA phosphatase N-terminal" evidence="1">
        <location>
            <begin position="39"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="RTG2 C-terminal" evidence="2">
        <location>
            <begin position="354"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF12940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="572" mass="62230" checksum="57DD538974B1F161" modified="2013-05-01" version="1">MAVEPARQDAQYLHAIVDMGSNGIRFSISSLQPPTQRIMPTLYQHRVAISLYDAQYSPTGEKVPIDGKTIIAVITAFKQFKRTCKDFGVPEQNTTVLATEATRTAVNSEVFRANIKKELGWDVQMLAKEDEGRVGAMGVASSLPMLSGLVMDLGGGSTQLSWIVKNSASDGVRLPPSGAVSMPYGAAAMSRRLSEAEKNGTTAKLREEVHTAVKNAYSSLQVPKELENAAQQQGGFTLYLSGGGFRGWGYVLMSQHRVQPYPIPAINGFKVSRSAFLSTDQVKAAAAESLEHTGEGELFRISDRRAGQVPAVAFLVNVLAEALPQVKEVRFCQGGVREGYLFSSLSTEAKAQLPLVVATRPFVQPTVSNALVRMLESAFPVGSTSGAVDDYKSVFIPDLLESFANLIYYHSSHPKDLQPSAALRCTTAGILAGVHGITHEARTLIALLLCARWGGSIPPSDEAFKHNLEQLVESPWILWWISYLGAVASLIANIYPAGPREDHDRLRLQASWAQDEKQRPLLQLTASITADVDQEAFLSEAHDIEKVGKRKRWIGGRDGIGHRVHVKVKIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>M3D453</accession>
    <name>M3D453_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Vesicular-fusion protein SEC18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SEPMUDRAFT_44240</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 12">Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761091.1">
        <property type="nucleotide sequence ID" value="XM_016908923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D453"/>
    <dbReference type="STRING" id="692275.M3D453"/>
    <dbReference type="GeneID" id="27906060"/>
    <dbReference type="eggNOG" id="KOG0741">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008037_2_0_1"/>
    <dbReference type="OMA" id="CFDNEIA"/>
    <dbReference type="OrthoDB" id="9982946at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035494">
        <property type="term" value="P:SNARE complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000026">
        <property type="entry name" value="vesicle-fusing ATPase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000166">
        <property type="entry name" value="vesicle-fusing ATPase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000012">
        <property type="entry name" value="Vesicle-fusing ATPase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000187">
        <property type="entry name" value="Vesicular-fusion ATPase SEC18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039812">
        <property type="entry name" value="Vesicle-fus_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23078:SF3">
        <property type="entry name" value="VESICLE-FUSING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23078">
        <property type="entry name" value="VESICULAR-FUSION PROTEIN NSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01072">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 12" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CDC48" evidence="14">
        <location>
            <begin position="110"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="252"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="533"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMF12970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="743" mass="81750" checksum="6FA60D3D5D890DA4" modified="2013-05-01" version="1">MQLQPVSSPKELIFSNLCAVSAQDIGPSRDGGDVHIMINGKYVLSARPHPQVQRGQIGLNDFQRTWMQVALTDIVEVEQYDPFRQGAQSYLGNMDIELGFAGTRPQQAPPFDQDELADAVIKVFRNQIFAPGQSFGLDFRGGPKLRLTIKTVELVDLASLKGSGQQQQQTHPHARGILTPETQINFYKDAKSPLQLKGSTRRPAANSVIRPDFKFEDMGIGGLDKEFSDIFRRAFASRIFPPGLAEKLGIQHVRGILLYGPPGTGKTLIARQIGKMLNAREPKVINGPEVLNKYVGQSEENIRKLFADAEKEQKEKGDESGLHIIIFDELDAVCKQRGSGAGGGTGVGDSVVNQLLSKLDGVEQLNNILLIGMTNRKDMIDEALLRSGRLEVHMEISLPDEPGRAQILKIHTEKMRTNGKLGSDVDLAELAKQTRNFSGAEISGLVKSASSFALQRHIKGGTVAALSDDINEMQLHMADFLGALNEVKPLFGVSEEVLEDCVEGGIIHYGPQVDKILKNGRDFVEQVRTGTTRLHSVLLHGPRGSGKTALAAQIALNSQFPFIKMLRAVDMVGMNEIQKIQHLQKAFTDAYKSPLNVLILDNIELIVDWVPVGPRFSSAVLAALKALMENRPPKNRPLLIMATTSERTVMQQLQLAFKAQIPIPALQSQQELAHVMQHSGQFSQQDIQRAISEIEQTMSGSKQIGVGVQHIILAIQTAMQDREDRTGRFVDLMCEYINDAAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>M3D4L7</accession>
    <name>M3D4L7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_148541</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761281.1">
        <property type="nucleotide sequence ID" value="XM_016904984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D4L7"/>
    <dbReference type="GeneID" id="27902121"/>
    <dbReference type="HOGENOM" id="CLU_2238291_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF13160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="105" mass="11312" checksum="54D100181BC6527F" modified="2013-05-01" version="1">MPLFRASSVAASIGRVTAPHTSSLARRLARSSFRFILMTGARLTCLSRTHHSQFHVASKPPISVRNSSRTGPIIITGQAYHGYGSASPWALLGRAMTNLQSSVPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>M3D6A3</accession>
    <name>M3D6A3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_116431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761510.1">
        <property type="nucleotide sequence ID" value="XM_016901255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D6A3"/>
    <dbReference type="GeneID" id="27898392"/>
    <dbReference type="HOGENOM" id="CLU_3033895_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF13389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="55" mass="5961" checksum="FAA0190F7A2619DE" modified="2013-05-01" version="1">MGPTADGRPMNKTGLCNVPALAVHGNEHYPQTTPPPALLKHVEQENRLWGVDMVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M3D6L9</accession>
    <name>M3D6L9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_85017</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cell membrane</location>
            <topology evidence="1 5">Lipid-anchor</topology>
            <topology evidence="1 5">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="5"/>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761936.1">
        <property type="nucleotide sequence ID" value="XM_016910373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D6L9"/>
    <dbReference type="GeneID" id="27907510"/>
    <dbReference type="eggNOG" id="ENOG502SHAA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021855_0_0_1"/>
    <dbReference type="OMA" id="ANHDGCM"/>
    <dbReference type="OrthoDB" id="421038at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF8">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005140305" description="1,3-beta-glucanosyltransferase" evidence="5">
        <location>
            <begin position="17"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="389"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="401"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF13815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="464" mass="48489" checksum="ECACEC0805E1CEAF" modified="2013-05-01" version="1">MLTFLSSLLCASIATALPTISAKGAKFFTSDGDQWFIKGVAYQLLPDDPLVDTNQCQLDAALMKTLGANAIRVYHVDSSADHDGCMQAFEDAGIYVFLDLDTFDTYVLPGEPTWDSTQYDAFSKVVDAFHTYDNVAGFFVGNELINGGADSIAAPYVKAAARDMKAYRDSKGYRNIPIGYSAADIAVLRPNLQNYMACGDDPAGALDFFSLNAYEWCGESTYEQSGYSALQKNASEYNIPIFVGTTHHTRHPCPSVQTIFFSETGCQVIKPRTFGDQAAIFGPEMSGTWSGAIIYEWIEEANDYGLISYGPAVDATVTGANVAGGFTIRGTPTPIQPDFNNLKSQWAAASPSGVQSAAYSPSLTAPACPETTPGAWLAAGSLPTMGQKANTAAGGSFSAESSPTPTGSSQSGGAIASASETMSGRMSGTSSSRTSSGTTSSGAAATKMATGGPALLALLGAALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M3D7J7</accession>
    <name>M3D7J7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_147966</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762281.1">
        <property type="nucleotide sequence ID" value="XM_016904623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D7J7"/>
    <dbReference type="STRING" id="692275.M3D7J7"/>
    <dbReference type="GeneID" id="27901760"/>
    <dbReference type="eggNOG" id="KOG1414">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034316_1_0_1"/>
    <dbReference type="OMA" id="HGAFMSQ"/>
    <dbReference type="OrthoDB" id="295274at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14687">
        <property type="entry name" value="bZIP_ATF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000053">
        <property type="entry name" value="BZIP transcription factor AtfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051027">
        <property type="entry name" value="bZIP_transcription_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002112">
        <property type="entry name" value="Leuzip_Jun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021755">
        <property type="entry name" value="TF_Aft1_HRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021756">
        <property type="entry name" value="TF_Aft1_HRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020956">
        <property type="entry name" value="TF_Aft1_OSM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19304">
        <property type="entry name" value="CYCLIC-AMP RESPONSE ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11786">
        <property type="entry name" value="Aft1_HRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11787">
        <property type="entry name" value="Aft1_HRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11785">
        <property type="entry name" value="Aft1_OSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00043">
        <property type="entry name" value="LEUZIPPRJUN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="7">
        <location>
            <begin position="419"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="168"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="195"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="288"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="312"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="329"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="339"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="394"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="408"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF14160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="537" mass="56807" checksum="5F1535C0D2D46B7B" modified="2013-05-01" version="1">MAAAVVASSPRLNNAKSQTASPRSNRTSLHAPDTAKKESTEKPDTSIPTIKQPEPEAESQDTGAPPANAPLAPPPKPAQTGDGDYFGSATHLTKEPNPFESAFSNPADTPGKTQLPGVTSLTSPASLLPGNTPGWPGSLRSGPLSPAMLSGPSGSNDYFNSDHHFSGSFPTPNESSLRTGLTPGGGGSMFPQPSPNSQAIYNSLQSGGATPGTLDFHRTAMTARAQSSQNTYGIGPGATSQAQQNPNIQPDLDSKPYNPNGQNSQSDNADPFGSHQSNEAANGLFMLAQAGGQQQQQQQQQRNPTSYPMPPQQGFQQTMQQDQRGGKNSIGSNMSGSTEHADHYSEEDGKANMRGTRGKKGAAGKGAANGKRKTDETPAKPPANKKARASTQSEEPEDVDDMSPEGDEMGKDGKKMTDEEKRKNFLERNRVAALKCRQRKKQWLANLQQKVEIFSTENDALAATVTQLREEIVGLKTLLLAHKDCPVSQAQGISGMAMQQIAGDSQHYANPYGMAMGQGGPGMGQQAQMAQAQMQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M3D828</accession>
    <name>M3D828_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_25295</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762431.1">
        <property type="nucleotide sequence ID" value="XM_016908391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D828"/>
    <dbReference type="STRING" id="692275.M3D828"/>
    <dbReference type="GeneID" id="27905528"/>
    <dbReference type="eggNOG" id="KOG3582">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126658_4_0_1"/>
    <dbReference type="OMA" id="VDYMRDQ"/>
    <dbReference type="OrthoDB" id="3818343at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057072">
        <property type="entry name" value="bHLH_INO4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF39">
        <property type="entry name" value="BHLH TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23181">
        <property type="entry name" value="bHLH_INO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="18"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF14310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="84" mass="9127" checksum="B6C2CA1903A5E678" modified="2013-05-01" version="1" fragment="single">SSPLSSANAAKARLTEEQKKKNHIESEKKRREAIRQGFDRLSTLVPGMQGQARSEAIVLAATVEHMRAMLAQREQIAAAATAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M3D8Y7</accession>
    <name>M3D8Y7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">adenosine deaminase</fullName>
            <ecNumber evidence="4">3.5.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_148273</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>adenosine + H2O + H(+) = inosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:24408"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.4" evidence="4"/>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762731.1">
        <property type="nucleotide sequence ID" value="XM_016904819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D8Y7"/>
    <dbReference type="SMR" id="M3D8Y7"/>
    <dbReference type="STRING" id="692275.M3D8Y7"/>
    <dbReference type="GeneID" id="27901956"/>
    <dbReference type="eggNOG" id="KOG1097">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022829_2_1_1"/>
    <dbReference type="OMA" id="SMKQCIE"/>
    <dbReference type="OrthoDB" id="7202371at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006154">
        <property type="term" value="P:adenosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046103">
        <property type="term" value="P:inosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000017">
        <property type="entry name" value="Adenosine deaminase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409:SF39">
        <property type="entry name" value="ADENOSINE DEAMINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="11">
        <location>
            <begin position="262"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF14610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="606" mass="69013" checksum="083A3D5C7B2745ED" modified="2013-05-01" version="1">MSDHPVEDAQTAVQQLKIDDGESATADEIEQREFDAWAQKEGLPNMGQPFIQKYLDGRDALIAQEKQRRSDHIFREAMTPMQNEAAAIVAAIRFEEQNTLWHPGYENALAKINDQPIYPGMMFSLAKERMESSKLWQIVKRMPKGALLHCHLDAMGDLDWLADIALTTPGMCIRAPRSMHTPKLRTDHLYPFSFKFAKQESQSNGPHLWSESYKPEDLIPVTIAAESFPEGGVDGFKQWLKSRVSLSQTDAISHHLGPGDVWERFRACFGILVSLHHYEPIFRKFIRVMLKGLNDDGVRWVDIRHIFLYPFYREGSEAPDEDYTYFFEVLEDEIDAFKASEDGKGFWGASFIWTTQRQLGPKAVVEDMKMCIEHKLAFPDTILGYDLVGQEDNGRPLQDLLPELFWFKKRCAEEGIDIPFFFHAGETLGDGDEVDENLFDAVLLGTRRIGHAISLPKHPLLVDMIKEKKILIESCPVSNEVLRFTGGIMSHYLPSLLARGVPCALANDDPAILGHGTNGMTHDFWQALQGWENLGLAGLGSLAENSVRWANYEECPAKQWQQEIKDGSFGKNLRAKRLKEWQDEFEKFCQWVVLEYGAETDINTLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M3D908</accession>
    <name>M3D908_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Scytalone dehydratase complexed with tight-binding inhibitor Carpropamid</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_148100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the scytalone dehydratase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762500.1">
        <property type="nucleotide sequence ID" value="XM_016904702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D908"/>
    <dbReference type="SMR" id="M3D908"/>
    <dbReference type="STRING" id="692275.M3D908"/>
    <dbReference type="GeneID" id="27901839"/>
    <dbReference type="eggNOG" id="ENOG502SNND">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101889_0_0_1"/>
    <dbReference type="OMA" id="SACYEWA"/>
    <dbReference type="OrthoDB" id="5281072at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030411">
        <property type="term" value="F:scytalone dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006582">
        <property type="term" value="P:melanin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004235">
        <property type="entry name" value="Scytalone_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049884">
        <property type="entry name" value="Scytalone_dh"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02982">
        <property type="entry name" value="Scytalone_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF024851">
        <property type="entry name" value="SCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Scytalone dehydratase-like" evidence="6">
        <location>
            <begin position="15"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR024851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR024851-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR024851-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF14379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="202" mass="23137" checksum="8C5928C8AF159044" modified="2013-05-01" version="1">MTGFANTQLEPVKLITFEEMQGCMAAVYEWADSYDTKDWNRLSKCIAPTLRIDYRSFLNKLWEEMPAEEFIKMASDPHVLGDPTLKTQHFIGGTKWEKVSDDEIIGHHQLRVPHQKYTDETCTTVMVKGHAHSYNHHWYKKINGVWKFAGLNPEIRWFEYDFDKVFATGRDHLAAEDAAQADKNLAAQAKGIPPATTTTTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M3D960</accession>
    <name>M3D960_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_148139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762545.1">
        <property type="nucleotide sequence ID" value="XM_016904730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D960"/>
    <dbReference type="GeneID" id="27901867"/>
    <dbReference type="HOGENOM" id="CLU_2122612_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF14424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="114" mass="12688" checksum="E26007FD3B679675" modified="2013-05-01" version="1">MKSMSSLPELLLSEEQEMCIQAMRSEVEQYIYGGRFGRRQETLQKLDTDDMEPDEPADDEFGEEADKASEHGDLSEAQEASLGIPCLSSEGKGCRLDMHDPESGLAMTPEEVNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M3D9F9</accession>
    <name>M3D9F9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SNF2_N-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_162800</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762881.1">
        <property type="nucleotide sequence ID" value="XM_016908019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D9F9"/>
    <dbReference type="STRING" id="692275.M3D9F9"/>
    <dbReference type="GeneID" id="27905156"/>
    <dbReference type="eggNOG" id="KOG0387">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_4_0_1"/>
    <dbReference type="OMA" id="IMITTYD"/>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000019">
        <property type="entry name" value="DNA excision repair protein ERCC-6-like 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029256">
        <property type="entry name" value="Heliccase-ass-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057931">
        <property type="entry name" value="RHH_ERCC6L2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25806">
        <property type="entry name" value="RHH_ERCC6L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14773">
        <property type="entry name" value="VIGSSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="150"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="523"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="829"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF14760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="918" mass="103784" checksum="C9055DE193D1974A" modified="2013-05-01" version="1">MSSLLDTSVRRRGAKDRIGEARKLLPPFRQRPQAASLVGKRKLHTKRRAAPLEEATDDETERPEDLLPDYLKKRRNEREAQQQKGDDLGFRTPPTHKDIGLGTSQHKKPNLPGVTPPRPHEAIELEYGTIPPSIAQYLKPYQIDGTRWLHEKFVKQQGALLGDDMGLGKTIQVIAFLTVAFGKTADERDLKRMRYKRKNEPGTWYPRVLIICPGTLIENWKVELDRWGYWHIYTYHGSASAKEDALAAAEGGRLEIMITTYDTYKRDESSINCVTWDCVIADEVHTIKERKSQNAQAMNNVNALCRFGLSGTTIQNKYEELWTLLNWANPGCVSTIANWKSAICMPLKIGQSHDATLSQLAKARRTAIGLTQNLLPNFWLRRTKALIAHQLPKKSDRVVFCPLTETQVTAYQNFTDSELVHAIRDSSEPCFCDSGKKQGHCCRESIEGFGGWKNQVFPALVTLQKLSNHVALMVPKADADAERLEKDLEKLRIALPDDWEELYQNRDNLSFLARPEFCGKWNVLKKLMKLWYDNGDKVLIFSHSVRLLRMLNLLLKFKTSYNISFLDGSMTYLDRQKEVDAFNSQPSQFAFLISTKAGGVGLNITSANKVVVVDPNWNPAYDLQAQDRAYRIGQTRDVEVFRLVSVGTVEEIVYARQIYKQQQANIGYNASVERRYFKGVQDNKDQKGEIFGLANLFAPVQANVVLRDIVNKTNIAETKAGIDIVGLDLEASQEDEDDFVLDPDSRTAAIEALAAEVIDEPSRKRKLAKEAAKKKDPVQAILAAAGVSYTHENAEVIGTSKIETKLSSRAQKGADDPDHINQLAFARSQQSQTPALPRPGTGFQANYGGGGDGEGEVRVKYKYQPPEEVRRRQFCSMSAHFGYEKVEEFALVVEGWTQQQRRDCLELFYKQRRAELTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>M3D9Y1</accession>
    <name>M3D9Y1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="11">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SEPMUDRAFT_19249</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="11"/>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762810.1">
        <property type="nucleotide sequence ID" value="XM_016908314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D9Y1"/>
    <dbReference type="STRING" id="692275.M3D9Y1"/>
    <dbReference type="GeneID" id="27905451"/>
    <dbReference type="eggNOG" id="KOG0345">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_1_3_1"/>
    <dbReference type="OMA" id="AYKEHEC"/>
    <dbReference type="OrthoDB" id="7396459at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902626">
        <property type="term" value="P:assembly of large subunit precursor of preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17960">
        <property type="entry name" value="DEADc_DDX55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 10 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="38"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="286"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMF14689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="506" mass="56647" checksum="9FF873770B62E87A" modified="2013-05-01" version="1" fragment="single">KKQPKSFEALTPELSQWILDFTRGMGFARTTPVQAMAIPLLLGNKDLVVEAVTGSGKTLSFLIPLVERILKAEEPNKKGHVRSIVVAPTKELASQIYDVLIGLLDFHKPSAAFLRQAAKPERDSEDEDMDGIDDDEVDDEVPPGPYAVPQLLVGGMNKLAEDLATFAQLGPNILVGTPKRLVEVLHSSKVVVKRHWFDLLVLDEADRLLDPNFQPDLQRILDIVPKERRTGLFSASVSEAVDELVRVGMRYPFKISAKVRSKTGALDKRTPESLKLYHLITKPSLRIPHLKLILQQSHAEKSIIYVSTRAGVDYWNHILQALLGMPVYPLHGDHKAAIRMKNLQRFRDATSSAILLTTDVLARGIDIPDIDLVVQLDPPKQPKDFIHRCGRSGRAGKRGMAVTFLSEGGEEDYVKYLSLQGTPLEPYPDAPTLTASDAREATNAIRNVLQQKRELHDRSQKAFVSWIQAYSKTLPTDIFGVRKLDWAETGRAWGLLRWPKMPELKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M3D9Z0</accession>
    <name>M3D9Z0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_138683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF14890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016902885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D9Z0"/>
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    <dbReference type="eggNOG" id="ENOG502RDXE">
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    </dbReference>
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    <dbReference type="OMA" id="HKDQANE"/>
    <dbReference type="OrthoDB" id="2400485at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34213">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2 (NTF2) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34213:SF2">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2 (NTF2) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF14890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="224" mass="25210" checksum="CD48948BD560D6AE" modified="2013-05-01" version="1">MASTSIGATGAPANAPGEQHEVRQTTTTEDMKPNPSQSLPLSAARQALVDDIIALYSCEPTIKRVERYTPDCVYDDQFVYANDRYKMAGQWFALPKLFKESRNEGYEVIKNEDNLIQFKNEQSWTFKIIPKTATINALVSLSLEPGSEETGFVRVKYHKDQANDKDYSHEGLGFSFKKWQADQVAKHMNAEEVKYFEKDKVAGKEPVRKYGSGDVDGSAPKKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M3DB25</accession>
    <name>M3DB25_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7924 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_147195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763396.1">
        <property type="nucleotide sequence ID" value="XM_016904140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DB25"/>
    <dbReference type="STRING" id="692275.M3DB25"/>
    <dbReference type="GeneID" id="27901277"/>
    <dbReference type="eggNOG" id="ENOG502SJYB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023878_1_1_1"/>
    <dbReference type="OMA" id="ISIYHDE"/>
    <dbReference type="OrthoDB" id="5336565at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057684">
        <property type="entry name" value="DUF7924"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25545">
        <property type="entry name" value="DUF7924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7924" evidence="2">
        <location>
            <begin position="267"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="446"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF15275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="479" mass="53409" checksum="03E48E9B5789C52A" modified="2013-05-01" version="1">MLLNGEQCRRKRHREEEEEQEEQHEEALALPADNQQQHPTKRRKKAHTPNYPPRFWDTLSRVHLTRRALQEFDRRTETARLVLSAETIKSSTRRLLRSDTHRLLHFASNGGPDLNALQGFSALPAVEASMSQSSTQSRKRDFSSSTARSSGARKTKTTTPYSPEFEQKLADRGVFSVAYCFADGRSPPNPNNIQELMDALSRRRSSLSSTAFSEEAFQEFRRNDTRASESAAMADLLPVIAGPKDKDYNPNGEVPFLRLEKFDPYISVPKPDRYYGAMPAQIDGSVRSDLTNYIIPSNRTNLPAAPNFFVEMKGISGRGNIAALQAMYDGAVGAKGILHLQNYGNAVPVHDANAYTITVTYCNSTLKIYATHPRESERGGETEYFMTELKAYGMTSDPETFRKGAAAYRNAREWAQEQRDNFITNANAAALRMSADRVSVSRTEVTADASSTAAGGSFVSETSADELASDTHTVKRRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-05-03" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>M3DCC0</accession>
    <name>M3DCC0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_139369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763816.1">
        <property type="nucleotide sequence ID" value="XM_016902901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DCC0"/>
    <dbReference type="GeneID" id="27900038"/>
    <dbReference type="HOGENOM" id="CLU_2832820_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004033212" evidence="1">
        <location>
            <begin position="25"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF15695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="66" mass="6669" checksum="9B61234B0A2ACF0D" modified="2013-05-01" version="1">MLFFSKFSLASLLMVASLAPTVLAACNTASDCTSPFPKCMICPGTANKCVSGAECGANTPATCACK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>M3DCR5</accession>
    <name>M3DCR5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_154548</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763941.1">
        <property type="nucleotide sequence ID" value="XM_016907568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DCR5"/>
    <dbReference type="GeneID" id="27904705"/>
    <dbReference type="eggNOG" id="ENOG502QQXX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006632_1_1_1"/>
    <dbReference type="OMA" id="AKCCALI"/>
    <dbReference type="OrthoDB" id="2264294at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001080">
        <property type="term" value="P:nitrogen catabolite activation of transcription from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF4">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN DAL81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="44"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="81"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF15820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="706" mass="78758" checksum="13C60A56CE2AC6FC" modified="2013-05-01" version="1">MASVMTASNNDSAAAAGPSKHHSRASHPDAAAAAAAAAVRRSRPCDACRRRKSKCVTEDGNSMCVLCKFHNQTCTYLEAPQPRKRNANSSGSGPTTAADSQTPAKRSRTLLLKPGTGVEEYDTLPGSLLRCTLGLQNRHHSEYIGLNAIPDVYSSPNLDASAAPNQDSQAQHDYVRFVHPSHAFRIIADDQTEGYDQGRTDVDEIEALASGHGGELVQLYFRVVHPSFPILHKDVYLEKYARSYREFSPPLLAAVYLLASSYWTYDEQLSRSPMIDTVALQALAFRTLQNAMRRPKLSTVQAGLLLSQWQKAFMGAANENRDRLTVQLVNMGHGLGLHLDCSHWELPEWEIGLRRRIGWALYMQDKWTALLESRPTLISADDWDVADLSELDFPENVEDDQEGSGEVERGRLVFTYMAHLSVILAEILRTIFSARARRLLDGAADRLAALLEWMKPLQLSLKEWFLTLPESLRMDTAASMKLSSVGYLRLAYLTVEVCLHKKLLRTLNNTSSTSLTIAHVCRAAASERFTNGTDFVQRLQAQHLHSFWYFPSAKCCALIHTLGQTLGQTASSEEEQAMYSRKLKELKWSLKVNSEAGASFMKQALALINQSVRIINQVGETSPTTTSSASHELRFPGHDTCTPEQSHAQPQAQQWMQLQQQAMQNGHVAYNAYQDYSMDQAPFPDPDAMFAGYPSELDGTWMHHQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDH5</accession>
    <name>N1QDH5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_120314</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757581.1">
        <property type="nucleotide sequence ID" value="XM_016901591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QDH5"/>
    <dbReference type="GeneID" id="27898728"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_22_3_1"/>
    <dbReference type="OMA" id="GRDEGWP"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF33">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="429"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="71"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF09460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="571" mass="60614" checksum="6C6149B85E4415EE" modified="2013-06-26" version="1">MKEEADGACHAADAERTSESSRLLSEHIPASQYQSIPSLGPTSRQNDLASGGCYYESQDSETESTKSPWSTLSLLLLGVFVAQIDQSLVLATYGQVASEFEELDSGSWLMSAYILAQCAVQPLYGKLSDVYGRKMCLLTAYTLFAIGTAGSGSSQSMGQVIASRAVQGAGGAGMVSLVAIIITDIVPKKDIALVRSYVNVLQTMGRSCGAIVGGVVTQAIGWRWAFLIQVPPTVLAIYLVAWKLDLSRRGTDEQATEGMSSWEKLGQVDFIGSLFLGLTILSLCLVLDLGGQRIPWDSSWMMAIIAGGILSAIAYMVSAKVVLHPIYPLELLRHRVVITNYMCAFLGIMGQLSLMTFVPIYFQTTTHASVAAAGALLIPAFAGNTVGGLLTGYLIKKTGRYKPYTVLAPVISLCGMISLLLAWNGNTTMVSSLLVIPGGFAAGVVSTSAFIGLVDGVPKEHVAVAASGSYLFLNLGAIAGVSIGSACFQAELRSTLERTLDNFPNKHSIIQHATADLEYLWMTEGRLQRVLINGYIQAFHAVNYMGIACSALALLCGILTPSHTIGSTAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDM3</accession>
    <name>N1QDM3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cyclopropane-fatty-acyl-phospholipid synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_151546</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CFA/CMAS family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757697.1">
        <property type="nucleotide sequence ID" value="XM_016906884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QDM3"/>
    <dbReference type="STRING" id="692275.N1QDM3"/>
    <dbReference type="GeneID" id="27904021"/>
    <dbReference type="eggNOG" id="ENOG502QSMW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026434_0_0_1"/>
    <dbReference type="OMA" id="WGGLAEF"/>
    <dbReference type="OrthoDB" id="8300214at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050723">
        <property type="entry name" value="CFA/CMAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003333">
        <property type="entry name" value="CMAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43667">
        <property type="entry name" value="CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43667:SF2">
        <property type="entry name" value="FATTY ACID C-METHYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02353">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003085">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF09576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="474" mass="53448" checksum="3EE596C8C2FB4B67" modified="2013-06-26" version="1">MLQSSAAALASYATPWIYPPLLSIARSQIINLLRNIQVGSLKITDTDGTTTVCGSPKTASLVDESQEKNVYAKSHSELIVHQDMFWVRLLLFADMGLAESYMLGEVSCTDLTAFFKLFISNKKYLSNGTTLSSNIMGRISGLIRKTNDLTNAKLNISAHYDISNAMFEAFLSPDMTYSCPIFLAKSDPMCAQETLEQAQYRKLNRFIRNCKIKSSDHVLEIGTGWGSFAILAVEKTGCRVTSLTLSEEQKKLADERIAAKGFSDRIQVLICDYRSLPVPQKEEQKYDKVVSIEMLEAVGAEYLETYFRCIDQLLKSEGGVACFQCITIPESRYAGYANSDDFIRRYIFPGGHLPTITQLLDSIRAGSSNTRKGVQPRLIPESIENIGPHYAKTLRLWRQNFMQSFTTRIRPALMLEFQERQGRKMSEEEVEIFKKKWEYYFAYCEAGFATKTLGDVILTVGREGAIEMMEDVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-12-14" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDQ3</accession>
    <name>N1QDQ3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_120494</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757777.1">
        <property type="nucleotide sequence ID" value="XM_016901610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QDQ3"/>
    <dbReference type="GeneID" id="27898747"/>
    <dbReference type="HOGENOM" id="CLU_1887055_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF09656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="135" mass="14886" checksum="D815C1CCA1B775BF" modified="2013-06-26" version="1">MADSEVNQTVAVGEEGKWAEACAESDVRPLRVVIVVVTGMVDGGRCVELAVTLRGDGLWVRWCGGDELVEEEEKQRRWRNKGGNLEKGRLEKVETRLGVAASRVTSYNTSHHNTSQHCTADAKTTFIHTHTPTNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDU9</accession>
    <name>N1QDU9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_150498</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758472.1">
        <property type="nucleotide sequence ID" value="XM_016906220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QDU9"/>
    <dbReference type="STRING" id="692275.N1QDU9"/>
    <dbReference type="GeneID" id="27903357"/>
    <dbReference type="eggNOG" id="KOG3166">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055193_0_1_1"/>
    <dbReference type="OMA" id="AICVQNV"/>
    <dbReference type="OrthoDB" id="29563at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000003">
        <property type="entry name" value="60S ribosomal protein L7a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001921">
        <property type="entry name" value="Ribosomal_eL8_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00882">
        <property type="entry name" value="RIBOSOMALL7A"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="6">
        <location>
            <begin position="125"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF10351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="265" mass="29467" checksum="09B134F5896F2AE1" modified="2013-06-26" version="1">MPPAKSGGKKAAPAPFPATKAGVSKKQAKNPLIERRPRNYGIGQDIQPRRNLSRMVKWPEYVRLQRQRKILNMRLKVPPAIAQFSNTLDRNTATQAFKLLNKYRPETKAEKKERLHKEATAVAEGKKKEDVSKKPYAVKYGLNHVVALIEAKKTSLVLIPNDVDPIELVIFLPALCRKMGVPYAIVKGKARLGTVAHKKTAAALAITEVRAEDKNELSKLVQAVKEGYLEKNEEAKRHWGGGIMGAKSVAATKKAAQRAEREIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDV2</accession>
    <name>N1QDV2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_150510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SO2202</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2012-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genome evolution in poplar pathogens from wild and recently domesticated pathosystems.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Dhillon B."/>
                <person name="Feau N."/>
                <person name="Sakalidis M.L."/>
                <person name="Gill N."/>
                <person name="Aerts A."/>
                <person name="Ohm R."/>
                <person name="LaButti K."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Copeland A."/>
                <person name="Beauseigle S."/>
                <person name="Grigoriev I.V."/>
                <person name="Goodwin S.B."/>
                <person name="Tanguay P."/>
                <person name="Hamelin R.C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758482.1">
        <property type="nucleotide sequence ID" value="XM_016906227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QDV2"/>
    <dbReference type="STRING" id="692275.N1QDV2"/>
    <dbReference type="GeneID" id="27903364"/>
    <dbReference type="eggNOG" id="ENOG502RDZA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047269_1_0_1"/>
    <dbReference type="OMA" id="YLEFLMA"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF2">
        <property type="entry name" value="ALPHA_BETA-HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="147"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF10361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="394" mass="44848" checksum="CE67F8E3E12C7C6C" modified="2013-06-26" version="1">MILDQIAWVDCIAFLLFLAPQLLIQIGLFPTIFCALKALPFLLFQLPVQLIRERYLTPHQQRSPFVQRASLFQDLVIRCVRYAFADIPAAIGKVFFSKWVALPFIRFRMLRHGIVRKPIYWTEVHRDGVRGIYAVMDATRKPDIMLYYCHGGGFSMGSTYFYLEFLLVWLTLLKQAGYANPALFALDYTLVPEATYPTQVQEALAGYKYVLSTVDSPSQVVVSGDSAGATLILSLMLCVSGYSSLKNQMPGLAIIISPWSTIISPKNQNTPSDYLNADSLHLYGTQYIGKNGSQDNALVSPGRCDDLGWWRRASPSNGWYFIYASEEVFAPEAKDLIAKLRRAEVRVDEYEEYGWVHAWPVVKLFLCKKQEERQHGLRKMVDVISERIERKKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFA0</accession>
    <name>N1QFA0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_149777</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760074.1">
        <property type="nucleotide sequence ID" value="XM_016905762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QFA0"/>
    <dbReference type="STRING" id="692275.N1QFA0"/>
    <dbReference type="GeneID" id="27902899"/>
    <dbReference type="eggNOG" id="KOG0684">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018012_0_0_1"/>
    <dbReference type="OMA" id="FWNLVHI"/>
    <dbReference type="OrthoDB" id="3366823at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11040">
        <property type="entry name" value="CYP7_CYP8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24306">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24306:SF7">
        <property type="entry name" value="AHBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="517"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF11953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="575" mass="64935" checksum="F7BFACC77AF62131" modified="2013-06-26" version="1">MAAVNESGHWTPPELQLVPRTWYQTLLDYPLPTALLATIIVLIVTRLSSSTQSKARTQNGASIIPAHPYWLPFIGHAPQMFYGDGFLEHLRVLYRKGAFALNLGGSRHNILYTPGHVTALLNAKKENADSEDVARKLMVSIFDLPVYDLEKYDAAHKDMVECYREILSNPGLEGLVENTAGRARDYVTNLVSFLESPVDQMPWEKNANITLLADAAQGSSSNPTVVEASLFPLIRDFVAFTANPSIMGSDFLQNFPTFFDDIWTLDSGFIMLAAGLPRWAPIPTLTRAHIARRDNLKRLEEFHENLQKHHRGEPVESKWSSLDDVGTLLKARMQVYEKHDFSIRTRSSYELALMWAANANSDTLIFWMINHVYSDRVLLAQLREEIAPYIKISHERTGLPIEAPPRISAIDTTRIFDSCALLKSVYVESLRFDTAPWSFKVIKNDFVLQSREKGAEPLLLRKGEYVHAAHDLHNSDPEYWNDPKTFQADRHVKKDDAGNSTADLGTIRPYGGGASMCKGRAFALREAMLFTAIVISMWDIQPQGGGKWKMPKHKKATGTYVTSDDTRVWISRRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFF7</accession>
    <name>N1QFF7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Piwi-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_150570</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the argonaute family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758593.1">
        <property type="nucleotide sequence ID" value="XM_016906262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QFF7"/>
    <dbReference type="STRING" id="692275.N1QFF7"/>
    <dbReference type="GeneID" id="27903399"/>
    <dbReference type="eggNOG" id="KOG1041">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004544_4_1_1"/>
    <dbReference type="OMA" id="RGRCYIH"/>
    <dbReference type="OrthoDB" id="10252740at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04657">
        <property type="entry name" value="Piwi_ago-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032474">
        <property type="entry name" value="Argonaute_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045246">
        <property type="entry name" value="Piwi_ago-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16486">
        <property type="entry name" value="ArgoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01163">
        <property type="entry name" value="DUF1785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00949">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAZ" evidence="3">
        <location>
            <begin position="387"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="4">
        <location>
            <begin position="679"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF10472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1026" mass="112916" checksum="625C3462079FE6E5" modified="2013-06-26" version="1">MSGNQPRGRGGGRGDRGAGQRGRGRGDSSAPRGDFQAGRGRGDFQPGRGRGDFQGNRGRGGGGPPGRGQSTQMPFRGGRGGAGGGRPPPGRGGIYLENQPVTPPDPAITAAENALVVQTKGKIIDDFPGRSGYGSKGKAIVLRTNYFSLTTAFEANVNEVPLYRYEVEIKEIKDISKPKRRRVFDSIVAHAAFANLRWATDYSSIIVTTEKLDLEKMMAGKVMVEVTLPPENGAVGPSSEGDQPPEFVKAARARNTFHFCLHDKGSFNPRAMVEYLKSTSAGAMYQGRADLIQLLNIIITKAPNEAAQVKDVGKNFYPFGTHPGMESYDLGQGLEALRGYFSSVRPAIGRLLVNINVTSGAFYKSMQLLDLVREVGSGNDQAESFIRMLKVEVRYTKDGQKEMFMKKAKTIVGFAKPHKKIHVKRFGNAHEVRISIEDRASPNTKSQEMTVAEYFKKNHGITLKRPELPLLNVGTRDAPQYLPMELCWVNPGQAYRRLLSGNQTSEMLKFAARFPNLNAMSIAGVADAPGNGLRLLRLAATGATPQNESVGPFGFRVGIDMISVPGRILQAPSVNYGKKSVTPRNGSWNLAGTKFAKPGKFNRWQVLVINLSGRNTLRGPVESIVGKLGTALMGYGINMGERGPTMQIELDRLTMMNRPKNDAVLKGAFERAEGKRVDMLFIIIPDVDRWLYARIKFFGDVVHGVGTICSVGSKLEKENGQDMYLGNLALKFNLKGGGISHSVANTVTAPIDANTMVVGIDVTHPSPDSAEDAPSVSCVVASVDSQMFQWPGSIRSQKGRQEMVEPLEEMFNERLDVWVRKNQKLPTKVVVYRDGVSEGQYQTVLREELPAFENVFKKRYGKKDRWPKMAIIIVGKRHHTRFYPTRVEDADYNPQRDKGSWNPLPGTIVDRGIVGKVIREFYLQAHQGLQGTARPAHYVVIKDDISFTADALEQFTHHLCYLFNRATKAVSICPPAYYADLLCERGRAYLFNTLSENTSSDSSVMGDAPEGISGVHDRLRDTTWYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFM6</accession>
    <name>N1QFM6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_134027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760229.1">
        <property type="nucleotide sequence ID" value="XM_016902605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QFM6"/>
    <dbReference type="STRING" id="692275.N1QFM6"/>
    <dbReference type="GeneID" id="27899742"/>
    <dbReference type="eggNOG" id="ENOG502RHJV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_847775_0_0_1"/>
    <dbReference type="OrthoDB" id="3640624at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF12108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="37295" checksum="B64B50C0D5F25144" modified="2013-06-26" version="1">MDNTFAARSARLSRDFPARSPPIHPRVPTTRPQQAETDSSATIETSQPIAQLPDHETASQLVQRLRIAPDLVQVYCSTHPGERPLFISQALLMQKSPLLLATAIQPPHHHHHHDYHHRSIGPASLFPTLDLSAHSPNPTVLSIFIYWLFHSRVPDAAAAVDVNVVSPNQTPHHHQHHQHQISLTHAWNFAKDWNLPLLQNEILKAFFRILEEEEPLDAKTFETCLEISGAGSALRFALLAVLLWWDDLHEELLGGSRRGGGRGRGREMLSDTIDIRGVEGFEEDFERALGVWEEEGRRRGRRYNAVDDVYVESRPWGRERPRAELFFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFR1</accession>
    <name>N1QFR1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Midasin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_165248</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the midasin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758708.1">
        <property type="nucleotide sequence ID" value="XM_016908159.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.N1QFR1"/>
    <dbReference type="GeneID" id="27905296"/>
    <dbReference type="eggNOG" id="KOG1808">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000050_0_2_1"/>
    <dbReference type="OMA" id="ILEQWHR"/>
    <dbReference type="OrthoDB" id="5186at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000142">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000582">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000712">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001368">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040848">
        <property type="entry name" value="AAA_lid_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048617">
        <property type="entry name" value="MDN1_AAA_lid_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012099">
        <property type="entry name" value="Midasin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041190">
        <property type="entry name" value="Midasin_AAA_lid_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103:SF2">
        <property type="entry name" value="MIDASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103">
        <property type="entry name" value="MIDASIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17865">
        <property type="entry name" value="AAA_lid_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17867">
        <property type="entry name" value="AAA_lid_7"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21108">
        <property type="entry name" value="MDN1_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010340">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0143">Chaperone</keyword>
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    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
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        <location>
            <begin position="4515"/>
            <end position="4729"/>
        </location>
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            <begin position="681"/>
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            <begin position="3967"/>
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            <begin position="3967"/>
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            <begin position="4080"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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        <source>
            <dbReference type="PIRNR" id="PIRNR010340"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50234"/>
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        <source>
            <dbReference type="EMBL" id="EMF10587.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
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    <sequence length="4741" mass="523695" checksum="87E21280E08E334D" modified="2013-06-26" version="1">[encoded data, 4741 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>N1QG45</accession>
    <name>N1QG45_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Peroxisomal hydratase-dehydrogenase-epimerase</fullName>
            <ecNumber evidence="5">1.1.1.n12</ecNumber>
            <ecNumber evidence="6">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Multifunctional beta-oxidation protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">SEPMUDRAFT_150759</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Second trifunctional enzyme acting on the beta-oxidation pathway for fatty acids, possessing hydratase-dehydrogenase-epimerase activities. Converts trans-2-enoyl-CoA via D-3-hydroxyacyl-CoA to 3-ketoacyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a (3R)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32711"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="1.1.1.n12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
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    <dbReference type="EC" id="4.2.1.119" evidence="6"/>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_016758878.1">
        <property type="nucleotide sequence ID" value="XM_016906380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QG45"/>
    <dbReference type="STRING" id="692275.N1QG45"/>
    <dbReference type="GeneID" id="27903517"/>
    <dbReference type="eggNOG" id="KOG1206">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_18_0_1"/>
    <dbReference type="OMA" id="GKTRWQR"/>
    <dbReference type="OrthoDB" id="3592703at2759"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018812">
        <property type="term" value="F:3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03448">
        <property type="entry name" value="HDE_HSD"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="hydroxyacyl-CoA-like_DH_SDR_c-like"/>
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        <property type="entry name" value="Peroxisomal multifunctional enzyme type 2"/>
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        <property type="entry name" value="peroxisomal multifunctional enzyme type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054357">
        <property type="entry name" value="MFE-2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051687">
        <property type="entry name" value="Peroxisomal_Beta-Oxidation"/>
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    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45024">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45024:SF2">
        <property type="entry name" value="SCP2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22622">
        <property type="entry name" value="MFE-2_hydrat-2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0456">Lyase</keyword>
    <keyword evidence="15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ketoreductase" evidence="22">
        <location>
            <begin position="10"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="589"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="765"/>
            <end position="791"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="596"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012456"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00052025"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00055743"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00073871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00081853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EMF10757.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="907" mass="98456" checksum="EF58610A6F889704" modified="2013-06-26" version="1">MGEQLRWDGQTVVITGAGGGLGRAYAVFFGSRGANVVVNDLGGSFKGEGASQTAAQKVVDEIKQAGGNAVANYDSVENGEKIIQTAIDTYGRIDVLVNNAGILRDVSFKNMKDEDWDLIMKVHVLGAYKCARAAWPHFRKQKYGRVINTASAAGLFGSFGQCNYSAAKLSQVGFTETLAKEGARYGIIANCIAPIAASRMTATVMPKEVLDLLKPDWIVPVVAALTHKDTPAEENGGIFEIGGGHVAKYRWERSNGALLRADESFTPGALLAKWKDIEDWTNPQYPTGVNDFMTLLEEGLKMKPSPKTQELDFKGKVAVVTGGGAGLGRAYCLTFAKYGAAVVVNDLADPEPVVQEIQKLGGKAVGVKCSAEDGDKVVKAAIDTFGRIDILINNAGILRDKAFHNMEDKMFQQVLDVHLRGTYKTSKAAWPYMLKQKYGRIVNTTSTSGIYGNFGQANYAAAKCGILGFSRALAREGKKYNIFVNTIAPNAGTNMTRTIMPEEMVQAQKPDYVVPIVAIMCSDKMPSEPTGRVFESGCGWAGETRWQRTGGAQFPVDVPLTPEAVKASWDKIANFDDGRADHPHDVSFANEKIMGNSENRSNKGGNKSESSDGNEYLAAIEEAKKLQAEGTEFVYDERDVILYNLGIGAKRTELPFVFEGHDNFQVIPTFGVIPPFNAQAPYDMTSLVPNFDFRQLLHGEQYLEIRQFPIPTEATLVASPHLVEVQDKGKSAVIVSGSITKDKNTGKEIFYNEATVFIRKAGGFGGKKQGSDRGPATKVHTPPKRQPDAVVEEKTSEDLAAIYRLSGDRNPLHIDPDFAKVGGFDVPILHGLCSFGIAGKAILQTFGEFQNIKVRFAGVVLPGQTLVTEMWKEGRWIIFQVKVKETGKLAISGAGAELRADSQKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGA5</accession>
    <name>N1QGA5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_33168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764327.1">
        <property type="nucleotide sequence ID" value="XM_016908528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGA5"/>
    <dbReference type="STRING" id="692275.N1QGA5"/>
    <dbReference type="GeneID" id="27905665"/>
    <dbReference type="eggNOG" id="ENOG502SSSB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115936_0_0_1"/>
    <dbReference type="OMA" id="SNGHAGW"/>
    <dbReference type="OrthoDB" id="4955652at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase zinc-binding" evidence="1">
        <location>
            <begin position="110"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF16206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="208" mass="23200" checksum="ADFF54EB730097A7" modified="2013-06-26" version="1">MFDLPSAHLHAGVDPDTRAAFAAHLHATPNKRRVSQAEQETLVHWLTSACCNSGTSSTTICPFKPLSQKEFSRRHYVKKSFVWDKDQEALVAIPRGGSGRERRVVLEDAIPDIVAKVHEQNGHAGWDATWRDVSKAYYGILRADVIFLLKLCSTCAQNPRKQPKNRATAVQDLVDVQPSAYDDDISWALNEHPLGSLLLFDNTDEQAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGC7</accession>
    <name>N1QGC7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_112266</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone H3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764321.1">
        <property type="nucleotide sequence ID" value="XM_016900966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGC7"/>
    <dbReference type="STRING" id="692275.N1QGC7"/>
    <dbReference type="GeneID" id="27898103"/>
    <dbReference type="HOGENOM" id="CLU_089044_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45810">
        <property type="entry name" value="HISTONE H3.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="82"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="167"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF16200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="190" mass="21412" checksum="E4393EF11C891A0E" modified="2013-06-26" version="1">MASAMSIAQKRKQSIVRKTPRTGGKGLPSRTGGKKLPGTRIKKGHRYAPGTLALKEIRKCQKESLLYIKKTLFARLIKELVMDQAHTPLQPKKNKATKALKAKATPKCKPLPTKQPRRIVEDDSDEDMPDATQNPTVENNNSEDTTAQQATLDNKQDDNEQDEDKQEQDKQDQDVRDQDVQGRDFQASYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGR9</accession>
    <name>N1QGR9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_133679</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759790.1">
        <property type="nucleotide sequence ID" value="XM_016902575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGR9"/>
    <dbReference type="STRING" id="692275.N1QGR9"/>
    <dbReference type="GeneID" id="27899712"/>
    <dbReference type="eggNOG" id="ENOG502QRB1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034579_1_0_1"/>
    <dbReference type="OMA" id="MFMGATE"/>
    <dbReference type="OrthoDB" id="4137487at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018825">
        <property type="entry name" value="DUF2427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018827">
        <property type="entry name" value="YTP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G12730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685:SF2">
        <property type="entry name" value="PROTEIN YTP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10348">
        <property type="entry name" value="DUF2427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10355">
        <property type="entry name" value="Ytp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109850" evidence="2">
        <location>
            <begin position="26"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2427" evidence="3">
        <location>
            <begin position="30"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Protein YTP1-like C-terminal" evidence="4">
        <location>
            <begin position="157"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF11669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="471" mass="51340" checksum="08D66B510F949DB4" modified="2013-06-26" version="1">MATFRTRPSALLPIALLLATAYAHGGHSEVPEGEAISPAPIDGTLWTHILVQSFAWGILFPTGMVLGMVRSRWHVPTQVAATAIAVPGYFLGHAHKGRQFGPNAHAKFANLLMLILIVQVGLGIYLRLHIERGFLGTIRKGLVKAHAILGGLLPVITWVQFLFGGIAAQGFCQGDHLGQCLAHFIMGSAFIGYGIVMLLLLLNGQPFLARTGRSQEFFDSSVIALWGCVNTFTEHRWGGPWVANDLQHTSMGIIWWAAGLLGIWLSSDRHGRPKRNLIPGIVIFMTGWGMSGHPQSLALSTHVHAVFGYTLMAAGLTRIIEISFVLKDKNTLVGPDGGDVDLEINSFQFLPPFLLVAAGFMFMGATEEQMALLSSNNVTHVSYILILYSIAFLMFLYVNMLLRLYSAYKDPNAATKSITLHDVERPRTNGVIGLPIAGDRAAVDAQDFELEGLISDDEREHSKTNGKPIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGS6</accession>
    <name>N1QGS6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Zf-MIZ-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_149593</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PIAS family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759795.1">
        <property type="nucleotide sequence ID" value="XM_016905649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGS6"/>
    <dbReference type="STRING" id="692275.N1QGS6"/>
    <dbReference type="GeneID" id="27902786"/>
    <dbReference type="eggNOG" id="KOG2169">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020537_1_0_1"/>
    <dbReference type="OMA" id="TPIVECK"/>
    <dbReference type="OrthoDB" id="28127at2759"/>
    <dbReference type="UniPathway" id="UPA00886"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.780">
        <property type="entry name" value="PINIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023321">
        <property type="entry name" value="PINIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038654">
        <property type="entry name" value="PINIT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782:SF4">
        <property type="entry name" value="TONALLI, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782">
        <property type="entry name" value="ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14324">
        <property type="entry name" value="PINIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02891">
        <property type="entry name" value="zf-MIZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51466">
        <property type="entry name" value="PINIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SAP" evidence="10">
        <location>
            <begin position="20"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="PINIT" evidence="12">
        <location>
            <begin position="118"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="SP-RING-type" evidence="11">
        <location>
            <begin position="301"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="76"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="402"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="467"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="420"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="472"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="515"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF11674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="542" mass="59081" checksum="E86DD63490831281" modified="2013-06-26" version="1">MAASGGHLLQQGRVSVESRIKTLVNNDLKEICRAFNFQVSGTKAALQKRCVEILDKIVSEGDVAAFRDFNYRVNNHGKPAPAQTQSPQSSANGFGTFHGPSGSASPATMLPGRAPASAGRNGNSSAAAGRMWFKSSPFYEEHEVVFPMLDLPEMPQNRHTVSAVVTLTPDQSARIKSDPSLKLLLYCGKGANPYAQIDVEFPNQLEVKLNNDDVKANFKGLKNKPGTTKPADITDKVRKNAGYQNQLRITYALTKERFQVSVYMARYISSATLTQRIKEGRHGGGVISKEQAIREISRANDDPDIVLSSEIMSLKDPVSILRITLPVRSTVCTHRQCFDGGMFLQMQEQAPQWLCPTCNKQISYQSLCIDKYFEEILQQTSSSIEKVTLEPDGQWHIVNEEESQNAAQSSRDNRAKYDNDFDDSDDDLVEVASHSTAKSKPTNGGSLPTASTPNFLAAPVSGAGYAMTPPLSSRGPSAAPSTSSAQPGAKRAASSVIDLTLSDEEDDEPPRPAKRQTTNTRRQSTRQDQLATTAGAARRRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGV7</accession>
    <name>N1QGV7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fungal N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_133710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759825.1">
        <property type="nucleotide sequence ID" value="XM_016902580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGV7"/>
    <dbReference type="STRING" id="692275.N1QGV7"/>
    <dbReference type="GeneID" id="27899717"/>
    <dbReference type="eggNOG" id="ENOG502SI2I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023458_0_0_1"/>
    <dbReference type="OMA" id="AYAEQMC"/>
    <dbReference type="OrthoDB" id="5404564at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38886:SF1">
        <property type="entry name" value="NACHT-NTPASE AND P-LOOP NTPASES N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38886">
        <property type="entry name" value="SESA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="691"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="335"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="691"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="749"/>
            <end position="777"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF11704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="814" mass="90577" checksum="F3AF8CECC4368C58" modified="2013-06-26" version="1">MALKSSLSVGDILKLSHTAWKLGRAFTRGTKGAPSEFAEVERELNGLSEALKLVAESLHEDDSILSQAEDQTKHAVNTIFESVAKTLQDLESFVERYQVIKKHDSGYDFLEKRSWSSVVLANYRTFKWTTEGGDIHALRTMLQMHVDCIDLTMQALQSRSLTRLKKTVMPVSRNVASIHDKSSADLAQRIRDAHELIAHIVNNPPSSEPRGRRQTASHFPPFHDIAGYQDERNARVVDWNFETGTPSHLRGSISHGRDWCASPIDSAYAGECSRRTSLRRESLTIPALLFATAGENHPPAASTDSRPDIDEEKIEPPMMPPLPPLPLHSTRRLPQRSSSRRSASQSRSAELPPPPVMPFGAPRVRQPVATPSHFFPSHWTESEVTEGVQTARPRMKSPHRETVQAEARSVNLAAKFEQQLLRNAAILCDVRGRLVEFAQHNPEILDMRYNVEMKEACKECRILVIRKRENREYGGTKVVTSVWCLSDDNEVRLQQKLSESQETVPYCSYFEPEKVSLEPPDEPGAGLRFHAEEWGGMLKEEKKTNWINYYFAIESDAINFQSAVFGRMLLGSFRTTKTTVIHKGILGAFAFEEQFANIELLRLWEEDGVETPGAVGGVMALMHISSSFGEGWARWWINNSRQPVTIKEDGVKYARVKGIDVTVVRPGATARRARSASSSVAGVVDTSLLHATPPLPSTSPSLSPSSSPSPSHLSSSSFQPQHQQHQPQHHQPIKTTSAVVFPTPPLPPTTTTTTTAVPITTTTTEKESSSSSSSSSSFKKVSGVRIEFKNEEERGKFLHAAELAQMRSVPLPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>N1QH01</accession>
    <name>N1QH01_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Bromodomain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_145734</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lucas S."/>
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                <person name="Zhong S."/>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="24"/>
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        </location>
    </feature>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF10563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="214" mass="23520" checksum="3D67B1E548F0FB6F" modified="2013-06-26" version="1">MPFSPPCGGVRMVLELTRIPTFYICDLQEKFAKAIYNYPAVIATTQKLLKASQVLSIPVIATTQLRGKLGETCPELGLDAPHGVQTLVHADKSKFSMWTPEVQKVFQQDLGGEKRECIIVGIESHICVTQTTLDLLREGHKVYVIADGVSSCNPQEIPIALARLRAEGAVVTSSESFLYELMGDAKIEEFKAIAGLVKEYSSKTKESLQALCKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1QHK1</accession>
    <name>N1QHK1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_33315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764776.1">
        <property type="nucleotide sequence ID" value="XM_016908535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QHK1"/>
    <dbReference type="GeneID" id="27905672"/>
    <dbReference type="eggNOG" id="ENOG502R9BU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142357_0_0_1"/>
    <dbReference type="OMA" id="ESPTHMP"/>
    <dbReference type="OrthoDB" id="5234213at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF16655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="88" mass="9118" checksum="254811C95789224A" modified="2013-06-26" version="1" fragment="single">KSLKDVAKENPTLIGDPVSLKAETSNTGDLDGDDAQQGGKKGKKSLKELAKGNPSQLGDPVSLKAETSDTEPTDQDRGALGGRRGSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1QHV2</accession>
    <name>N1QHV2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_145937</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764896.1">
        <property type="nucleotide sequence ID" value="XM_016903352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QHV2"/>
    <dbReference type="STRING" id="692275.N1QHV2"/>
    <dbReference type="GeneID" id="27900489"/>
    <dbReference type="eggNOG" id="KOG0127">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011608_3_0_1"/>
    <dbReference type="OMA" id="FTHRHAL"/>
    <dbReference type="OrthoDB" id="267048at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12676">
        <property type="entry name" value="RRM3_Nop4p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12677">
        <property type="entry name" value="RRM4_Nop4p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000406">
        <property type="entry name" value="Related to Nucleolar protein NOP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034809">
        <property type="entry name" value="Nop4_RRM4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034808">
        <property type="entry name" value="Nop4p_RRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051945">
        <property type="entry name" value="RRM_MRD1_RNA_proc_ribogen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN 14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039:SF5">
        <property type="entry name" value="RNA-BINDING PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="52"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="162"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="330"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="515"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="128"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="247"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="690"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="247"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="266"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="317"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="690"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="747"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF16775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="761" mass="83804" checksum="494B15055D3C484C" modified="2013-06-26" version="1">MAPAAKRQRLSDGSAAAVPLPPTTQAGSGVGAGGEGGGLSIEQQKQATQKRCSLFVRSLPASTTNDQLTELFSDAFPVKHATAVIDPETKLCKGYGFVTFADAEDAAQAKAQFNGHELGGKKLRIEVAEPRSRDSKAKDEGKESVGQLKRKEAEVERQHQPSKLIVRNLPWSIKGPKQLEKLFQSYGKIKKAYVPQKGPGLMAGFGFVIMRGRKNAEKAIEGVNGKEINGRTLAVDWAVEKDVFEENADADEGNEAEDAEHMGEDLTGEDEDDDIEAEGEEGEEEEDAYEENGSADDASEDSDTLEGDDDDDGEGDWNDRQHENADDKPTTLFIRNLPFTCTDEDLEDHFREHFGSTRYARVVMDHGTGRSKGTGFVCFYDKADADGCLRGAPLKPVTTAQEKSKEAKPTQASHSILQNEMADATGQYTMDGRVLQISRAVDKSDANRLAEESASQRHKRDGDKRRLYLLGEGTIASNSKVWEQLAPSEQAMREASAKQRKQLIENNPSLHLSLTRLSVRNIPRSVTSKDLKELARQAVVGFATDVKEGRRARLSKEELLRGGEEMQAAEAARKKSGKGIVRQAKVVFESAGGSKVNEESGAGRSRGYGFIEYYTHRNALMGLRWLNGHVVKYQVKEGKGKLSRDEIQDRKKRLIVEFAIENAQVVMRRNEAEQKARARSLAVEQGMAAANKDAPAKAAFKPRFKGDRPGLRKRKRDADAVPPSNAAADTPKSVEKEKLAKRNQIIGRKRAMRARRKDGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1QIE0</accession>
    <name>N1QIE0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_143541</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759069.1">
        <property type="nucleotide sequence ID" value="XM_016903048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QIE0"/>
    <dbReference type="STRING" id="692275.N1QIE0"/>
    <dbReference type="GeneID" id="27900185"/>
    <dbReference type="eggNOG" id="KOG1379">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029404_1_0_1"/>
    <dbReference type="OMA" id="FKTEGQW"/>
    <dbReference type="OrthoDB" id="25675at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000118">
        <property type="entry name" value="Phosphatase 2C-like domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320:SF24">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="3">
        <location>
            <begin position="88"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF10948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="385" mass="41691" checksum="F8903F59C9D1A47C" modified="2013-06-26" version="1">MLLTTRSRCASRPRSRSPQSGLSTPAPKSSSQNSSNSNSHSSSSSSSSSASPFYLASGYSGWAKRPSRPFPPPFFSPPSGSFSDPLSTHHRSVDRVDGQMIRGVTNGDDAILAEKNLILANDGVGAWATRERGCAGLWSRLIGHFLAVEVEEKSLGDGEGEGNGEPDLVGWCAGAYERTKEVLMREGEEWLGTTTVSAALLHYRGKGGAQQPVLYVIQLGDCRVMVVRATEKGENNEVKDPEVVFSTKEQWHYFDCPRQLGTNSPDTPEENGVVDKVDITEEDIILAMSDGVTDNLWEEEIADHAVGALQKWKENFSSSEQGGNNVAEAMKYVAQEIVLSARKIAEDPFAASPFMEKAVEEGLAIEGGKMDDISVVAAMCRRRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1QII6</accession>
    <name>N1QII6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_149566</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759751.1">
        <property type="nucleotide sequence ID" value="XM_016905635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QII6"/>
    <dbReference type="STRING" id="692275.N1QII6"/>
    <dbReference type="GeneID" id="27902772"/>
    <dbReference type="eggNOG" id="ENOG502S025">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_0_2_1"/>
    <dbReference type="OMA" id="DLEYAHC"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="29"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="310"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="331"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF11630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="391" mass="43197" checksum="F6DB112D0B2A333B" modified="2013-06-26" version="1">MPVGHAPGSAVVGVTVAFTVLAFIATASRLITRVAIVRGAGIDDVMITIAVMFSIAITTTMVMQVQYGMGRHADTLSTNDNKYSLVWFWASVWLYYLGLMFTKLSILFQYLRIFPDRRFRFWCISLMALVCGWTCWAFFSALFACWPIQHFWNPSIPGACLNRLAVWFSNAAMNIITDIATTILPLPVLKSLNLPKRQRYVLMFVFGMGGVVCVISVLRLSSLYTISISTDVSWDNPLAAIWSSCEVNVGILCSCLPTLKGCVARYFPVLFSSACGSRPTGEFRALELSGRGRKNQASCTISAVGSVPLTGERSSSKMARMKSRLGRGEKDMEEGGSEDSESYYGRLTPTDRDHAIHVTTVVQQEEERSPRFAPMEGESLMGLVNQKPYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1QIP1</accession>
    <name>N1QIP1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_122510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765217.1">
        <property type="nucleotide sequence ID" value="XM_016901774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QIP1"/>
    <dbReference type="GeneID" id="27898911"/>
    <dbReference type="HOGENOM" id="CLU_2043768_0_0_1"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF17096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="121" mass="14103" checksum="B2253EB7866A955C" modified="2013-06-26" version="1" fragment="single">MAWPGLQHIYRSSQRAGDLARRITMRRVWPIFIHDSHCIVRCEHFLGTASLHAHRPRNVSTFIHTRLAAMAGPLSDPRVPTKKQRKHCIHIHPATIAALREAEEGRARHWTKERMPPWAWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1QIU5</accession>
    <name>N1QIU5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome c oxidase assembly protein COX19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_146212</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for the assembly of mitochondrial cytochrome c oxidase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the COX19 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765241.1">
        <property type="nucleotide sequence ID" value="XM_016903520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QIU5"/>
    <dbReference type="STRING" id="692275.N1QIU5"/>
    <dbReference type="GeneID" id="27900657"/>
    <dbReference type="eggNOG" id="KOG3477">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141947_3_1_1"/>
    <dbReference type="OMA" id="GTNDEAC"/>
    <dbReference type="OrthoDB" id="268594at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="entry name" value="CHCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051383">
        <property type="entry name" value="COX19"/>
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    <dbReference type="PANTHER" id="PTHR21107">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21107:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX19"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF06747">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
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        <location>
            <begin position="32"/>
            <end position="66"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="79"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="96"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF17120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="111" mass="12584" checksum="1798DDB328D37376" modified="2013-06-26" version="1">MSTFGGPGGRTTFSKPTPPERGSFPLDHEAECQPIMKQYLRCIKSKRGVNDEECRQLSKGYLQCRMDRNLMAPDSMRNLGFQSAEDQAQDAMRAQVKADLDAEQEANKRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>N1QIV6</accession>
    <name>N1QIV6_SPHMS</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_57227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016909427.1"/>
    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502TB6V">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_171961_0_0_1"/>
    <dbReference type="OMA" id="GIRQWIS"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="PIGBOS1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23670">
        <property type="entry name" value="PIGBOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110374" evidence="1">
        <location>
            <begin position="21"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF17130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="96" mass="10480" checksum="3169B0E9C4866053" modified="2013-06-26" version="1">MRGGNVAGLVIATVCGVATAYTTLQPALEEEAEKKAGTFNSRQEKDRTAKDTQLSRAIISDLKEAKREVIGEDKGNGGFAWGIRRWLAGEDKRNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1QIW6</accession>
    <name>N1QIW6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_164150</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016908098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QIW6"/>
    <dbReference type="GeneID" id="27905235"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_27_4_1"/>
    <dbReference type="OMA" id="PMWFFLN"/>
    <dbReference type="OrthoDB" id="2428527at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17476">
        <property type="entry name" value="MFS_Amf1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF1">
        <property type="entry name" value="LOW AFFINITY AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="355"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="411"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="449"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="491"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="51"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF11760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="534" mass="57534" checksum="A90371DB7F621F3E" modified="2013-06-26" version="1">MSGTATRITRSADIIEKMYRLPEEEEEEENASLTPTKSLLQEVSLPREILVVGIIALAQFTTQCGLGQTLAILHIIGDDFGVTNPGTLSWLIAGYSLTVGTFILFTGRLGDLFGWKKMLVIGYCWFGVWSVVAGLSVYSNHVLFVFARVFQGIGPAICLPNGLALLGGLYGPGKRKNMAFAIFGSCAPGGSMAGAAFAALFAQLAWWPWTFWSFGIALFVIAAAAAWAIPDPQTDKPGLKGHALCSWGAVWELDLLGAGIGILALVLFNFAWNQAPIVGWGNAQCIVTLIAGIFLVPVFFWIEQKIARNPLLPMEICTTSNAFVLGCVALGWANFGIWVFYLWQILEELRGSSPLLASAYLSPLTISGAVAAVVTGALLHKTRPAVVMIIALCAFMTGSILIATLPVHQIYWAQIFVTTLVTPFGMDMSFPAATLVVSDSVEKSKQGVAASLVNTIVNYSISLGLGFAGTVEVHVNRGGRTPPDLLHGYRCALYLAIGLAGLGILLAIFFLLKTLRDERRRMRRRDGCIPTVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJ23</accession>
    <name>N1QJ23_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme E2-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_57325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765296.1">
        <property type="nucleotide sequence ID" value="XM_016909430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJ23"/>
    <dbReference type="STRING" id="692275.N1QJ23"/>
    <dbReference type="GeneID" id="27906567"/>
    <dbReference type="eggNOG" id="KOG4784">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029122_1_1_1"/>
    <dbReference type="OMA" id="QAMKVFY"/>
    <dbReference type="OrthoDB" id="386949at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051865">
        <property type="term" value="P:protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019193">
        <property type="entry name" value="UBQ-conj_enz_E2-bd_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31531:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE E3D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31531">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE E3D FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09814">
        <property type="entry name" value="HECT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF17175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="379" mass="41516" checksum="925102D0CE224928" modified="2013-06-26" version="1">MLLYAEHLFNIHAISIQAVLPSPSNKETCATISTDGSSLTLAHNGHVASIKLPAAVPKGRTTAALPIPEAPCERMSFRVQLQQATLADGSQEVESIVPWTAAALNADTELSCMHCQQIVLARGKVLTWKNLPSENWAEMMDFWHCHRPHVAHDHDRDPPTKGYSVDSTLALNPGIGMVDPVDFVLASKDCGNLKITSSHNSQNKEAGQLECVSCSTVLGHVHTSGGYKLRKLHLAATSAIDQPSRSYEAEKWWSCLLLSSIECQGVRKFTIQDSRNGTRSLRLWVFTPDMTVSSSAMTSPEPMRAVKVFWQDCEMSFQDSGALNRNTLAEGELELPAGETQELRAKLVMSAAILPDSARTFQGWNVALLPRFTPADLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJ44</accession>
    <name>N1QJ44_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mob1/phocein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_32327</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765326.1">
        <property type="nucleotide sequence ID" value="XM_016908492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJ44"/>
    <dbReference type="STRING" id="692275.N1QJ44"/>
    <dbReference type="GeneID" id="27905629"/>
    <dbReference type="eggNOG" id="KOG0440">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038321_0_0_1"/>
    <dbReference type="OMA" id="HTYTWLD"/>
    <dbReference type="OrthoDB" id="10261121at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF17205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="259" mass="29179" checksum="8709EA0D658E8D0F" modified="2013-06-26" version="1">MQQSVQNGRKPPVFFREEYIGFIVKGNFMTLAAKPALVEEGEWLSHQVVEQNRLLSGMVKIVQTEDRSNGVGLCNEKSCPTMSAGGTTYTWIDTNRNPIHLPAATYIKHIQTWVAGKVQDETVFPTATFQQAPPLPLPQQAGNDPNNWLGKASGFPPRFEVEIKNMYKQMFRCYAHLYWSHWMQFWDLNVYRDLNTCFMHFVNVGRIFGLLSERDTEPMQPLIDLWVRRGDLPDGEHKTGAADAAKPATAAAAAPAPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJC1</accession>
    <name>N1QJC1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xylose isomerase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_133870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760021.1">
        <property type="nucleotide sequence ID" value="XM_016902594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJC1"/>
    <dbReference type="STRING" id="692275.N1QJC1"/>
    <dbReference type="GeneID" id="27899731"/>
    <dbReference type="eggNOG" id="ENOG502QQ4I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035063_0_0_1"/>
    <dbReference type="OMA" id="THINTWE"/>
    <dbReference type="OrthoDB" id="5360893at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050312">
        <property type="entry name" value="IolE/XylAMocC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110">
        <property type="entry name" value="HYDROXYPYRUVATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110:SF21">
        <property type="entry name" value="XYLOSE ISOMERASE-LIKE TIM BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="1">
        <location>
            <begin position="24"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF11900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="349" mass="40106" checksum="4A4A88349999FB4D" modified="2013-06-26" version="1">MPCRPAISSQSLGRACEHTLFPKIKAASEAGFEGIETFYEDLAYLADVYTQERLEDHGATEKTTEAHASELSEGDLLRAAQDVRDWCTQFHLEIIALQPFQTYEALKFTSAHGEKLMLRLWLPLCHKLQTQIILLPSSPLPPTQLSEEAISTTLCKAADLDATERPPVKLAYEALAWGTLVDKWDYFWKEVQQANRENLGICIDTFNLAGRVYADPTSPDRRLFPDEQEIEYSLDVLKKDLDMSQAFYVQIVNAEDMERPIVQVHAWYKKEQPARVTWSRNARLFAYEEGVYFPVRRIMEVLIKDCKYEGWVSIELFNMGLVDSSSSVPREYAERGMESWKRLEEDFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJC5</accession>
    <name>N1QJC5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_146360</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765416.1">
        <property type="nucleotide sequence ID" value="XM_016903600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJC5"/>
    <dbReference type="STRING" id="692275.N1QJC5"/>
    <dbReference type="GeneID" id="27900737"/>
    <dbReference type="eggNOG" id="KOG1632">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015434_1_0_1"/>
    <dbReference type="OMA" id="TIYKKTC"/>
    <dbReference type="OrthoDB" id="436852at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16039">
        <property type="entry name" value="PHD_SPP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037869">
        <property type="entry name" value="Spp1/CFP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46174">
        <property type="entry name" value="CXXC-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46174:SF1">
        <property type="entry name" value="CXXC-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="9">
        <location>
            <begin position="256"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="365"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="437"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="95"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="235"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="378"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF17295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="642" mass="70334" checksum="DE1081FAB8EC35D0" modified="2013-06-26" version="1">MASVSSLLNPSDGDNSHPSLPPAPLVPDQPAQNETTEVAQEPDTLSGQWQEQDSNTRLERQPVHELPRPSRSPERSSAPESPQQSHATLPPIHNWASTTPQTSAVQLSGATSPADHALKSVALLKMESSQRAQSPLRESSIPVPSTEDPTKDELPVPAKSKRPAPAKTKKGTAATVRKERPPPAKKRKLEKLDSKRADTPSSRASKAPTVKGASTKGTPMNSSPAPSMRSNSAEPVDEQDEEDEDEDDEGRSQDGDLYCICRKPDSGTFMIGCDGKCDDWFHGKCVNIPERDKNLIDKYICASCHEAGLGPTTWKRMCRREGCRQPAKLSKSKSGGHTSKYCSEDCGVLYFQDLAAHARGQVDSAGRRAARSQDSLEPSDKQNKDVEARGGALAAGEVKALLNASQTAEEFRRLGDGVLSPPATPDDLDEKIEAAFTEAEIRELQRIDEEKEGARQRHTLLKDRMKFITLAKQAASRVTMERELKSKDYCGYDPRMEWPEDRFLAWRNSPSGKKAFELDTLASESPDNVDDHDDDGSAPVSEICDRKKCARHLEWSKLTVDHLRLEMSDNGDRMRSLDREESEIRARAALRIKTGALGDVGGTVELHTPRTTVADPEAMVVDGATNMAPTLEQLNAMAVDQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1QK46</accession>
    <name>N1QK46_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Luciferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_76027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764758.1">
        <property type="nucleotide sequence ID" value="XM_016910118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QK46"/>
    <dbReference type="STRING" id="692275.N1QK46"/>
    <dbReference type="GeneID" id="27907255"/>
    <dbReference type="eggNOG" id="ENOG502SPCX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063954_1_0_1"/>
    <dbReference type="OMA" id="TWTGDYP"/>
    <dbReference type="OrthoDB" id="5358398at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048273">
        <property type="entry name" value="Luciferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040841">
        <property type="entry name" value="Luciferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38695">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38695:SF1">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17648">
        <property type="entry name" value="Luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase" evidence="1">
        <location>
            <begin position="165"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF16637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="242" mass="27183" checksum="1F7E12BED7EACE5C" modified="2013-06-26" version="1">MDSLTSSEAEASPALVEEYQQWRAVGPGGAPFDWNGFMLCKKAEITQARDDTTNLALYDSPEQYAKGWKEATEAQRRAAQTCFLKQPLPERPGPRSRAKHFVFPQRERNDGEPQDAQVQAAYQTAFEQLGEVNSRVEWKTSVLEKHGRALFLQDPVTPLISSSKGEICHVHRSDLSGHVTLSFADAREVIGKGWGERHRLSGTETLHLGYTMLYVPRNVAEVEVYAQIYQAGIEYMTSGHQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKS4</accession>
    <name>N1QKS4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="13">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SEPMUDRAFT_149664</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RAD25/XPB subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="13"/>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759902.1">
        <property type="nucleotide sequence ID" value="XM_016905697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QKS4"/>
    <dbReference type="STRING" id="692275.N1QKS4"/>
    <dbReference type="GeneID" id="27902834"/>
    <dbReference type="eggNOG" id="KOG1123">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008213_0_0_1"/>
    <dbReference type="OMA" id="RCQEIDY"/>
    <dbReference type="OrthoDB" id="10262986at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000112">
        <property type="term" value="C:nucleotide-excision repair factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18029">
        <property type="entry name" value="DEXHc_XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18789">
        <property type="entry name" value="SF2_C_XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000077">
        <property type="entry name" value="Probable DNA repair helicase RAD25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000117">
        <property type="entry name" value="Putative DNA repair helicase rad25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050615">
        <property type="entry name" value="ATP-dep_DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032438">
        <property type="entry name" value="ERCC3_RAD25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001161">
        <property type="entry name" value="XPB/Ssl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032830">
        <property type="entry name" value="XPB/Ssl2_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00603">
        <property type="entry name" value="rad25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274">
        <property type="entry name" value="RAD25/XP-B DNA REPAIR HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16203">
        <property type="entry name" value="ERCC3_RAD25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13625">
        <property type="entry name" value="Helicase_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00851">
        <property type="entry name" value="XRODRMPGMNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 18" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="360"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="579"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="824"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="824"/>
            <end position="833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMF11781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="847" mass="96034" checksum="CC4139B1F91546A9" modified="2013-06-26" version="1">MPPKRKATAADGRAKKRVASGAGTPVSLVSDDDYDESDDFDEEVERQAAPEYDKVVKRYQPATYQKPTTSHGDVASHLFKAGRDFFNEPLKPDHHLRPLWIEPKNGKVVLETFAPNFKQAQNFLINIAEPQSRTTNMHEYTISPHSLFAAVSVGLTEKDIIRDLELFSKTKVPANIIDFVHEVTQSFGKVRLVLKHNKYFIESNDALVLQTLLRDPIIAGTRVEETEELVTEKAAQKRDLIISGTAEARADREALAQAATVQKRGDDDESDDEFGGREAEKTMTEFLREEEDDEDTDLVHSFEIDGNKIQLVQEHCNVRLNLPLTEEYDFRADDINATLDIDLRPNVQIRYYQEHALSKMFGNGRARSGIIVLPCGAGKTLVGITAACTVKKSAIVLCTSAMSAVQWKEEFKKWSNINPDDIAIFTSGEKDILNLSKKAGVIICTYSMVTQNTRRAHDSKKVMDFITSREWGLMVLDEVHVVPAEMFRRVTERIKTHSKLGLTATLLREDDKIKDLNFLIGPKLYEANWLQLSEEGHIARVQCAEVWCPMTTEFYKEYLDAKTTNKRSLLSTMNPRKYQACQFLIDFHEKRGDKVIVFSDNVYALQKYATGLTKPYIYGDTSQREREIVLQNFQQNDAVSSIFLSKIGDTSLDLPEATCLIQISSHYGSRRQEAQRLGRILRAKRRNDEGFNAFFYSLVSKDTNEMYYSSKRQAFLVDQGYAFKVITHLNGIEKMPNLAFNTQQERMTLLTDVLLQSETAGDVEDIQDDLFSDRNVSRSKKKGSGVRRQAGTLSSLAGADNMAYMEHERGKNPNKALAKPRNQFFKKNAAAAQRRAKAQKELNNYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKU2</accession>
    <name>N1QKU2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Adenosylhomocysteinase</fullName>
            <ecNumber evidence="7 11">3.13.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SEPMUDRAFT_146796</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine</text>
            <dbReference type="Rhea" id="RHEA:21708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="3.13.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 11">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="10 11">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <dbReference type="EC" id="3.13.2.1" evidence="7 11"/>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016766002.1">
        <property type="nucleotide sequence ID" value="XM_016903871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QKU2"/>
    <dbReference type="STRING" id="692275.N1QKU2"/>
    <dbReference type="GeneID" id="27901008"/>
    <dbReference type="eggNOG" id="KOG1370">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025194_2_1_1"/>
    <dbReference type="OMA" id="YIGVTVE"/>
    <dbReference type="OrthoDB" id="10007170at2759"/>
    <dbReference type="UniPathway" id="UPA00314">
        <property type="reaction ID" value="UER00076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004013">
        <property type="term" value="F:adenosylhomocysteinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033353">
        <property type="term" value="P:S-adenosylmethionine cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00401">
        <property type="entry name" value="SAHH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Adenosylhomocysteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000004">
        <property type="entry name" value="Adenosylhomocysteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1480">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00563">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042172">
        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00936">
        <property type="entry name" value="ahcY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004005">
        <property type="entry name" value="PRK05476.2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420:SF0">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00670">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001109">
        <property type="entry name" value="Ad_hcy_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00996">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00738">
        <property type="entry name" value="ADOHCYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00739">
        <property type="entry name" value="ADOHCYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10 11" id="KW-0520">NAD</keyword>
    <keyword evidence="4 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S-adenosyl-L-homocysteine hydrolase NAD binding" evidence="13">
        <location>
            <begin position="198"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="160"/>
            <end position="162"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="229"/>
            <end position="234"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="306"/>
            <end position="308"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMF17881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="474" mass="51790" checksum="C6FEEF7C05EA231D" modified="2013-06-26" version="1">MGEPASQFKVADINLAAFGRREIELAEQEMPGLVQTREKYAAEQPLKGARIAGCLHMTIQTAVLIETLKALGAELTWTSCNIFSTQDHAAAAIAASGTPVFAWKGETEEEYQWCLEQQLKAFPSGKPLNLILDDGGDLTALVHTKYPEMLEGCYGISEETTTGVHHLYKMLKNKGKGNGLLAPSINVNDSVTKSKFDNLYGCRESLVDGIKRATDVMIAGKIAVVAGFGDVGKGCAQALHSMGARVLVTEIDPINALQAAMAGYQVVTMEDAAPISQIFVTTTGCRDIITGKHFEVMREDAIVCNIGHFDIEIDVAWLKKTAKEVVSIKPQVDRFLMPNGRHIILLAEGRLVNLGCATGHSSFVMSCSFTNQVLAQIMLYKAGDREFATKYVEFARAIEGEADGPVKIQEEGQVKSSVPRMPIGVYVLPKILDEQVALLHLDHVNAKLTKMTEVQAEYMSLPIEGPFKTDMYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>N1QL36</accession>
    <name>N1QL36_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">UAA transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_55550</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764449.1">
        <property type="nucleotide sequence ID" value="XM_016909366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QL36"/>
    <dbReference type="STRING" id="692275.N1QL36"/>
    <dbReference type="GeneID" id="27906503"/>
    <dbReference type="eggNOG" id="KOG1583">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033007_1_1_1"/>
    <dbReference type="OMA" id="NPFTGWH"/>
    <dbReference type="OrthoDB" id="999962at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005462">
        <property type="term" value="F:UDP-N-acetylglucosamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005464">
        <property type="term" value="F:UDP-xylose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF4">
        <property type="entry name" value="NUCLEOTIDE SUGAR TRANSPORTER SLC35B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="360"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="376"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF16328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="385" mass="42279" checksum="C7AFD82DDAC6BADA" modified="2013-06-26" version="1">MIPGIEPVTTTALIFGGCCTNVFTLETIVKVEPGSGLIITFLQFLFVTFFAYPSQFSSSSSSSSSGAESSLLLQRPKVPMRRWAFIAFMFFGINMLNNWAFAYNISVPVHIILRSFGSVTTMIAGFVRGKRYSLLQVLSVVLLTVGVLISAWADSQRKGKKMSYESHTSSSDYTEGLAILLLAQFLSAYMGAYTEDTYARFGASWTENLFYSHVLSLPFFLPLSGTLRNQYHRLANTPYLDVQRSGLHNFVQQNQGTSIGDLMGHILSYAARTPQGIFYLVINAFTQLICISGVNLLSSKSSAVTVTIVLNIRKLVSFILSTLIFGHSLNPLMIFGSTLVFGSGALYGWETSWRIPQQKARAQARVDGSGSGGAGNDEKKKLKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1QLD4</accession>
    <name>N1QLD4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_75632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764564.1">
        <property type="nucleotide sequence ID" value="XM_016910112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QLD4"/>
    <dbReference type="STRING" id="692275.N1QLD4"/>
    <dbReference type="GeneID" id="27907249"/>
    <dbReference type="eggNOG" id="KOG1027">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054430_0_0_1"/>
    <dbReference type="OMA" id="IQERPHL"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF16443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="344" mass="39000" checksum="517B3F32AAA7252E" modified="2013-06-26" version="1">MASLPSELIGATGRRYRFMNILQERPHIGRVWTASSGQDIFVLKDIPVNIFSNFNARILPQLSKMSTTSLRVPLDTIPDQRVFVYKYLSDDFLHLVRKGLPIQACRKVLRATLQAISHLHGRDVVHLDIKPDNIMVQCRRTAHTTTIEQVQLTDLENAAYLPKGRCIKGMLAGNDNWRSPEAHFKGELNKPSDMFSFGLVCIYAILGRVICGPDEDFAHHETQGALPAMIRLQRQVSYFGDSEGLNGLMTHVGDEEVNCQVLSMLWEDRDQDGIPYKPFSEWSELCDEQFIDLIKGLMNLDPARRISAYQALQHPWFLDRHGSIDSLDDTSGRLVTDDPIPADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1QLF1</accession>
    <name>N1QLF1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Required for respiratory growth protein 9, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_146205</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for respiratory activity and maintenance and expression of the mitochondrial genome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RRG9 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="NGRN/Rrg9"/>
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    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    </feature>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMF17112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="435" mass="49737" checksum="1EEBCB68C722117F" modified="2013-06-26" version="1">MMVKCYCTTEALETLLRNIAGLQVHQQRAQFVLQRYRSFSTRAPLRQVETANAGTVEVGFVPSEMTRKLQQSVVQSRVVQEKDAEQSDQTVAGSADGKDGSVNPQSHADIDTNGGVVANGHTSTHRAVPSPLADEETLPELVKPAAQKSLPRDQKVQRNASTEARRLRKERRMWEGKYKPTSVARMAQREGQRETPTQQIIAEEHSEDSNQVQHVLAKLDQELGGPSIIQAQQQRAERLASQSSEKNRKARMIAAEKHEEKQRATAEAEAQRRKQMEPWMRDKAALQNKFGAKGWAPNKRLSPDSLEGIRALHKSDPETYNTAMLSEHFQITPEAIRRILKSKWKPQPEEIEKRMERWEARGVKKWQEMSELGMKPPKKWRMLGVANPKLEGRPVKKWEDQRIEAPIDQRTGRKGRWRDRERQQTDPETSLAHRL</sequence>
</entry>
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        </submittedName>
    </protein>
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    </gene>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
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        <location>
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            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF12251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="338" mass="35614" checksum="47A3D2186027EE17" modified="2013-06-26" version="1">MASTAPITTSATATTATGPVTALTTTFTPPAKCTEQSLMFTMLSAPNYEVWANEPMPVSSSTVTECYPSEWIGAYQTANTSSIVPAMSPLVCPLSWETVMTAPGNYIACCPPGFRRTDPKTTVDGYRPFYGGTCYSELPSGSAVRVTQYNNLSISATVTFTASSQNVGLYAHPIDGYAYQAQETIFVSSNATSLSPSSSSSSSLATPTSTPTPNSSKTLSNGAIAGIVIGSLAGIATALLLLFFLHLRLRRASTTTTPPLHPPETVEIDGNEIQKELDGTQVFEIQGFAKHPIAEVEGRLSSSFLQRAELENGKVAGAVELEAGRREGEEGRDGKVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1QM77</accession>
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        <recommendedName>
            <fullName evidence="7">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_122411</name>
    </gene>
    <organism evidence="8 9">
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            </authorList>
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            <strain evidence="8 9">SO2202</strain>
        </source>
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        <subcellularLocation>
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        </subcellularLocation>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HOMEOBOX_2"/>
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    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="38"/>
            <end position="98"/>
        </location>
    </feature>
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        <location>
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        </location>
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            <begin position="1"/>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
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        </location>
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        <location>
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        </location>
    </feature>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="6">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
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            <end position="458"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF16988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="509" mass="55172" checksum="24DDF621B50F5F26" modified="2013-06-26" version="1">MDNESPNAPSMSPSGSQGVAGPSTGLQDDPSSSTDDKRLARQKRKRTSPDDQAVLEAAYKLDAKPDKAARLQLVEQVALGEKEVQIWFQNRRQSCRRKSGRPLLPHEIAQYQMAKSVNAQLPGRGYDELARQSVDPSIRGHSLNRQDIPSPSQSASEEDTREHQFEPGLHQTEKTPVEPPSQAAPALLSAPQPMINRAASISSPMFATSHIGHLANRRSATSLHRSFSETAVPLPPSASCEPGRPRKKSNAIRLSMNAEGNAIVTTQDTSSPSPPRPSQAALLPAIHSKLDGRPLFTSGNSSTRPSNGRSRDSRSWEFWCDKDARSELEGVAEKESHGSATGAIGLLRTSSGRSVLSPLSAKRNAPLGAYEASAKRTKRRSLMRSQTALARLQGRPDQAQVPSKLKKSGSASTKYVHSGESDKENWSPVRDLDFDDAALESRDDLSTNSTLRRGGTTTRSDRSCVDDPEADPELSSFMAQGRKRHAPAGEEELDCVQGLLSLSQGNWAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1QMJ5</accession>
    <name>N1QMJ5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Aa_trans-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_145868</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764790.1">
        <property type="nucleotide sequence ID" value="XM_016903311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QMJ5"/>
    <dbReference type="STRING" id="692275.N1QMJ5"/>
    <dbReference type="GeneID" id="27900448"/>
    <dbReference type="eggNOG" id="ENOG502QRQD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027816_0_1_1"/>
    <dbReference type="OMA" id="WGVAYIR"/>
    <dbReference type="OrthoDB" id="294730at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000039">
        <property type="entry name" value="Neutral amino acid transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF20">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="434"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="476"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="93"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="14"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF16669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="524" mass="57372" checksum="D689BD39A65C414C" modified="2013-06-26" version="1">MAVLNTNTAEKHYDVKHGLDDDGSGSGFAPSPDAAETGGRRKDFTKMNRIDKPWTTSITGSAAGGDMTDSTSEDFSIEKQMEAEEGNAIQYRTCTWQKTAALLFSEYICLAIMSFPYSYATLGLVPGLILTVVVAAMVLYTSLIVWEFCLRHPEVKDVCDIGQMLFWGKKWAWWFTAIMFLLNNTFIQGFHCLTGAKYLNTMTNGNSGVCTIVFSAIVAIASWVCSLPRTFETLSTLAGFSALFTFISVILATIFAGIEDHPGAGWPSLGAPTVYAVTPSTVTFVAGMNAFMNISYTFIGQITLPSFIAEMKNPRDFPKALWAVTIAEIILFSLVGSIIYAYTGTNYNTSPAFGSLGNEVYKKVSFSFMIPTIIFLGVLYASVSARFVFFRLYAGSRHMTSNTVAGWAGWAAILAVTWVFAFIIAEVIPFFSDLLSLMSSLFDSFFGFIFWGTAYLRMRHADYGPGFWKGRGFRGWVGFVLNVFLIAVGFLFLSAGTYASVESIKQGYASNNFGGPFSCAPNGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1QMX6</accession>
    <name>N1QMX6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mitochondrial outer membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_33772</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765878.1">
        <property type="nucleotide sequence ID" value="XM_016908550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QMX6"/>
    <dbReference type="STRING" id="692275.N1QMX6"/>
    <dbReference type="GeneID" id="27905687"/>
    <dbReference type="eggNOG" id="KOG3028">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055680_0_0_1"/>
    <dbReference type="OMA" id="RNAWLYT"/>
    <dbReference type="OrthoDB" id="198787at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03193">
        <property type="entry name" value="GST_C_Metaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033468">
        <property type="entry name" value="Metaxin_GST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050931">
        <property type="entry name" value="Mito_Protein_Transport_Metaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289">
        <property type="entry name" value="METAXIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289:SF44">
        <property type="entry name" value="OUTER MEMBRANE PROTEIN (SAM35), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G13180)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17171">
        <property type="entry name" value="GST_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17172">
        <property type="entry name" value="GST_N_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin-like fold" evidence="3">
        <location>
            <begin position="67"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Metaxin glutathione S-transferase" evidence="2">
        <location>
            <begin position="221"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF17757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="36378" checksum="A1401CA70B38E7AB" modified="2013-06-26" version="1">MADGPVQPRASIFSLPPPVKRVFDQFPLREYEANDLPWRAPRAASAHKLHVFTTEQDAKHGRPSYNPSCLKWQTYLRLSGIECTLVSSNNHASPSGSLPFLQPAIADGTRTTPDPVPANKLKKWLTKQALNRALDLSDIHDTRADAYQSLVDNRLRKCWLYQLYLAPQNDALMQRLYVYPCSNNALVRFATTRQLRGAAEAELVKSAGTNVVDAAVLIKEATEAFEALSALLQRDEWFFGAKEPGLFDASLFAYTQLILDEELGWRYNPLKEALEQHDKLVEHRGRILGSFYSDREEEEKNERPSVHTRTTSTLGKRKTPKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNA0</accession>
    <name>N1QNA0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">6-phosphogluconate dehydrogenase C-terminal domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_130617</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016766093.1">
        <property type="nucleotide sequence ID" value="XM_016902368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNA0"/>
    <dbReference type="STRING" id="692275.N1QNA0"/>
    <dbReference type="GeneID" id="27899505"/>
    <dbReference type="eggNOG" id="ENOG502RXGX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052530_0_1_1"/>
    <dbReference type="OMA" id="YAGINKG"/>
    <dbReference type="OrthoDB" id="9988102at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015814">
        <property type="entry name" value="Pgluconate_DH_NAD-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09130">
        <property type="entry name" value="DUF1932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="2">
        <location>
            <begin position="6"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphogluconate dehydrogenase NAD-binding putative C-terminal" evidence="3">
        <location>
            <begin position="233"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF17972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="342" mass="36943" checksum="0149EE620D08A3DE" modified="2013-06-26" version="1">MSRATLGIISIGDMGIGIAKLLIAHDYKVITNISGRSKATYDRAQANSIQIVADDIELCNSSDVILSIVPPRDAVEVAQRIAEATSSPKYKHNERKETLYFLDLNAISPARAREIEALFASSSSSSSSSSSSSSSASQDVQVKMIDGGIIGGPPHANNKNNNNNNSTEDNNNSEWTRPSIPLSGPHHLQPQLAQVLNTRHISDEVGSASGLKMCYASLSKGFTALAIGSYTTAKSLGVLEELQHELDERSPGVRGRAERGLVGMPPKAYRWVDEMREIAKTFEVDGGFHQETESPFRAIAEIYQLVAHGTELGKEVIGNRQRGQTAEDVAVLVEEGTKKRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNC1</accession>
    <name>N1QNC1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Exoribonuclease phosphorolytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_15620</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF18012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016766133.1">
        <property type="nucleotide sequence ID" value="XM_016907662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNC1"/>
    <dbReference type="STRING" id="692275.N1QNC1"/>
    <dbReference type="GeneID" id="27904799"/>
    <dbReference type="eggNOG" id="KOG1069">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063514_2_2_1"/>
    <dbReference type="OMA" id="SYKCPAT"/>
    <dbReference type="OrthoDB" id="27298at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11372">
        <property type="entry name" value="RNase_PH_RRP46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF1">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0271">Exosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="6">
        <location>
            <begin position="11"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF18012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="197" mass="21134" checksum="1FEE322869E854A7" modified="2013-06-26" version="1" fragment="single">MGPQILQHPLARADGSTVFSDDLYTVIAGVNGPVDVQRRDELPDQAAIEVNLRPTSGVGGPRERWLETVIQSVLKSIVLVHMHPRTLIQVTLQITKEPATKFRKTTTDISTLPALLNAAFIALVDGGLPMATTMSAVLAVVATNGETILSPNANAIQNSSSVHALAFNKNGEQILSQSAGRFDFDTWKRVVDAAQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1QND0</accession>
    <name>N1QND0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_146274</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765295.1">
        <property type="nucleotide sequence ID" value="XM_016903547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QND0"/>
    <dbReference type="STRING" id="692275.N1QND0"/>
    <dbReference type="GeneID" id="27900684"/>
    <dbReference type="eggNOG" id="ENOG502S2AR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008243_0_0_1"/>
    <dbReference type="OMA" id="PMDINQK"/>
    <dbReference type="OrthoDB" id="9368434at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF13">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="125"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="510"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="142"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF17174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="765" mass="83997" checksum="0D75C0D505C658F7" modified="2013-06-26" version="1">MSAPASSHPRRRPARQCDPAETLLDSFQNLSIRKGDTYHPTSNTSKSSFWDPLESRLATPAMPMRSSTSPQSLEDLLLGAGERRLTQLLGRVDKAVAAKSKIALGNALSESEVLPVPTFVVDQAPEQERAPKTRTRHHSHSSDSGIGSSIADSTESISTAKISSRPTTDAPSSPDSPSFSSISEAADEERCLSKYAAEQIHKHIVQPILREDALSDFHDLIKTVPTSIDDKDIRTLRDLEKRLIFLAPEHSLSPSKYLRFCERTIRVLHTTVTTLHESDQRARNERPYTQGYFLDLVEQIRRYASILAATREQQAKGDKPESMDSTKDPIVSLHGGLSHNGKPAELVHTTPEGKLISLASGEAISDEDLESAAMKRPALDVHEDDATRSMARRKKNAKPEIHTCELCTKQFKRPCDLTKHVKTHERPWKCSEVDCKYHEFGWPTEKERERHMNDKHSSAPSLYHCMFKPCPYTSKRESNCKQHMEKAHGWDYVRSKSNGKGKVQNVVRLPHGSVPPSPSSTMLTPLTPIAPSPSTLSYGESSRRSSMAPPPLAGPSTSNTISYGNTPAADFLGHFNMDHTGNFDFNDMTNFRTSAFPITPALSDDLGTSASVSTHSGAHYPNSIFGDLSPNQFTFDNNDFAFPANWHPVQTPDSSIAGPGSSATHISPAAHMEQSFNEDAVMEDTYGDFSNGPARDFTLFGSNVPAETSGDMFPSVSSWGNVDHMGMNFATPPSLPNGNTNAALAELFPELSEGSSKTSFEAVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M3ARC6</accession>
    <name>M3ARC6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">COQ4</name>
        <name evidence="8" type="ORF">SEPMUDRAFT_152331</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Lyase that catalyzes the C1-decarboxylation of 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid into 2-methoxy-6-(all-trans-polyprenyl)phenol during ubiquinone biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoate + H(+) = a 2-methoxy-6-(all-trans-polyprenyl)phenol + CO2</text>
            <dbReference type="Rhea" id="RHEA:81179"/>
            <dbReference type="Rhea" id="RHEA-COMP:9551"/>
            <dbReference type="Rhea" id="RHEA-COMP:10931"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:62731"/>
            <dbReference type="ChEBI" id="CHEBI:84443"/>
            <dbReference type="EC" id="4.1.1.130"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion inner membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
            <orientation evidence="7">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the COQ4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF08029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756150.1">
        <property type="nucleotide sequence ID" value="XM_016907381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3ARC6"/>
    <dbReference type="STRING" id="692275.M3ARC6"/>
    <dbReference type="GeneID" id="27904518"/>
    <dbReference type="eggNOG" id="KOG3244">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061241_2_1_1"/>
    <dbReference type="OMA" id="WFEMINT"/>
    <dbReference type="OrthoDB" id="4249at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120539">
        <property type="term" value="F:4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03111">
        <property type="entry name" value="Coq4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007715">
        <property type="entry name" value="Coq4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027540">
        <property type="entry name" value="Coq4_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12922">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12922:SF7">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN COQ4 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05019">
        <property type="entry name" value="Coq4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00081568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF08029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="198" mass="23166" checksum="F24A651933AC6830" modified="2013-05-01" version="1">MLAHPDGRRILRDRPRITSQTISLEKLRTFPENSVGRAYAAWLDREGVTPDTRDQVRYIDDPEEAYVMQRYRETHDFTHAITGLPVIIEGELAIKAFEFTNTLLPMTGLSLAAVVRLKAVERKRFFDIYLPWALRNGLKAEEVVNVYWEEELETDVGVLRNRLGIEMPPDLREMRKALREERKRERMEREKLGAIKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M3AS15</accession>
    <name>M3AS15_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Calcium-binding mitochondrial carrier protein Aralar2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_151993</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756420.1">
        <property type="nucleotide sequence ID" value="XM_016907175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AS15"/>
    <dbReference type="GeneID" id="27904312"/>
    <dbReference type="eggNOG" id="KOG0764">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_6_1_1"/>
    <dbReference type="OMA" id="AFYNGMG"/>
    <dbReference type="OrthoDB" id="10266426at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015218">
        <property type="term" value="F:pyrimidine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990519">
        <property type="term" value="P:pyrimidine nucleotide import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000075">
        <property type="entry name" value="Nicotinamide adenine dinucleotide transporter 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049562">
        <property type="entry name" value="SLC25A33/36-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829:SF1">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06780)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="36"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="147"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="260"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF08299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="395" mass="42963" checksum="EBB5D655BD788693" modified="2013-05-01" version="1">MQNARGSAMSSQSGGPPAVVQRSPFPKLAIWTTKFSDSNVNTFCGATAGLAAAIATCPLDVIKTKLQAQGSFSNPDLQHKGPPVGEMYRGLVGTAKVIIRQDGIKGLYRGITPMALGYTPTWAVYMTVFQAGSEYLRTNGYGDTPVKMFMCRMFAAVIAGGCSTLTTNPIWVIKTRFMSQPSRSASDGTKSLLRYSSTMDAARQIYRSEGLAAFYAGLAPAMLGLSHVAIQFPMYEYLKARFAGLELGVESRPDEVQSRQTAWAVTAASMISKLCASTATYPHEVIRTRLQTQQILHPEYAHNGVGEHSRSISSSRRIANTDGVAYQPRYRGLVYTFRTILKEEGWRAFYNGLGTNLVRAVPSAVTTMLTFETVKTAIVDLQSEGKVLKGENSPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M3AT14</accession>
    <name>M3AT14_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PA14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_74506</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756780.1">
        <property type="nucleotide sequence ID" value="XM_016910067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AT14"/>
    <dbReference type="STRING" id="692275.M3AT14"/>
    <dbReference type="GeneID" id="27907204"/>
    <dbReference type="eggNOG" id="ENOG502SQPX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030583_3_0_1"/>
    <dbReference type="OMA" id="VLAGPCK"/>
    <dbReference type="OrthoDB" id="4388755at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018871">
        <property type="entry name" value="GLEYA_adhesin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10528">
        <property type="entry name" value="GLEYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA14" evidence="2">
        <location>
            <begin position="191"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF08659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="388" mass="39380" checksum="E2A3898FC6ED7942" modified="2013-05-01" version="1">MSSDPSGISTSQISTSGGGSTSTSSLVVITSNTLSAVPTITATSEAVTSGDSATSTSTIETTPTDSGTTSDAATSGDSSTSTSSLVVITSNTLSAIPTFPATSISTIETTPGDTGTTSEATISSELSAIPTLPTTIETTPTDSSTSSATTTSSGLSTDSSIVSTTRTINLTTNVTTASTVTTTRCPPPTTCGNQGVAFAVYANVNGNNQGGSDPYSEFVPQQYKTRAPECTGVTTGVGGINYATNANSLTIYSQCTRSSSALFALNHQGYIYAVLSGTYSFVVSNADDWVGIWIGPKAYSGWLRSNVDASVAYGFGSATYNTTFVAGQYYALRIMFAQAQGDAAFAMRVTAPDGTVFLGAGVASSAYLVQYSCDGVTAPRFPAFGSQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M3ATK9</accession>
    <name>M3ATK9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Nicotinate-nucleotide pyrophosphorylase [carboxylating]</fullName>
            <ecNumber evidence="5 12">2.4.2.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">Quinolinate phosphoribosyltransferase [decarboxylating]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SEPMUDRAFT_151761</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Involved in the catabolism of quinolinic acid (QA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>nicotinate beta-D-ribonucleotide + CO2 + diphosphate = quinolinate + 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12733"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29959"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 12">Hexamer formed by 3 homodimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the NadC/ModD family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.19" evidence="5 12"/>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756970.1">
        <property type="nucleotide sequence ID" value="XM_016907027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3ATK9"/>
    <dbReference type="STRING" id="692275.M3ATK9"/>
    <dbReference type="GeneID" id="27904164"/>
    <dbReference type="eggNOG" id="KOG3008">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039622_1_0_1"/>
    <dbReference type="OMA" id="DIVMCDN"/>
    <dbReference type="OrthoDB" id="10067394at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034213">
        <property type="term" value="P:quinolinate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01572">
        <property type="entry name" value="QPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000090">
        <property type="entry name" value="Nicotinate-nucleotide pyrophosphorylase [carboxylating]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.20:FF:000003">
        <property type="entry name" value="Nicotinate-nucleotide pyrophosphorylase [carboxylating]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.20">
        <property type="entry name" value="Quinolinate phosphoribosyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004393">
        <property type="entry name" value="NadC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027277">
        <property type="entry name" value="NadC/ModD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037128">
        <property type="entry name" value="Quinolinate_PRibosylTase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002638">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022412">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00078">
        <property type="entry name" value="nadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179">
        <property type="entry name" value="NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179:SF3">
        <property type="entry name" value="NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01729">
        <property type="entry name" value="QRPTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02749">
        <property type="entry name" value="QRPTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006250">
        <property type="entry name" value="NadC_ModD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54675">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 12" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Quinolinate phosphoribosyl transferase N-terminal" evidence="14">
        <location>
            <begin position="44"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Quinolinate phosphoribosyl transferase C-terminal" evidence="13">
        <location>
            <begin position="122"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR006250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMF08849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="312" mass="33465" checksum="115416271357BF4A" modified="2013-05-01" version="1">MPITEGAPIHGNPAHLLPPSWKKSITLWLEEDTPSFDYGGFVVGDGPAEARLLAKSFGIVAGVPFFEEVFKQLDCTVEWFVKEGDEVGKEKKQHVATVRGPVRCLLLGERVALNLLARCSGVATKSHSLLQLLRNAGYKNILAGTRKTTPGFRLVEKYGMLVGGCDQHRHDLSTMTMLKDNHIWACGGSIPTAVAAAKAAGGFAVKVEVECQSEEEANTAIEAGADVVMLDNFTPEGVRVASKNLKDKWGRGVNARALVEVSGGLTEDNVADYVCDDIDIISSSSIHQGVKHIDFSLKVIPKGTSTGKPVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M3AVD5</accession>
    <name>M3AVD5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit M</fullName>
            <shortName evidence="5">eIF3m</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_151078</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN7/EIF3M family. CSN7 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit M family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758132.1">
        <property type="nucleotide sequence ID" value="XM_016906583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AVD5"/>
    <dbReference type="STRING" id="692275.M3AVD5"/>
    <dbReference type="GeneID" id="27903720"/>
    <dbReference type="eggNOG" id="KOG2753">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035254_0_1_1"/>
    <dbReference type="OMA" id="FNDEHKG"/>
    <dbReference type="OrthoDB" id="10267031at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03012">
        <property type="entry name" value="eIF3m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045237">
        <property type="entry name" value="COPS7/eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027528">
        <property type="entry name" value="eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040750">
        <property type="entry name" value="eIF3m_C_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350:SF2">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18005">
        <property type="entry name" value="eIF3m_C_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="7">
        <location>
            <begin position="192"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="400"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="427"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF10011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="438" mass="48841" checksum="D2C167BA06AAB6D6" modified="2013-05-01" version="1">MPGLSLVEGSFEELSLEIATYLDNAKGDDGTTVADITPFLADAEKEGSKTDIDAVLKKLVTASSILNGAPEKEVQAAYNLLIHLISHAEDEDPYIARICTYLAQPLTGSPFNGGGIALGILSTLFNQIKPDDETRFHVLLAVISVIKSTGNFDTLAPQLKNVDSWIEEWELEPAEARKLYTAISDAASTAKETEEAYHYLLKALNTIQADAATPEARELSVRALKLALQKDKHFDFQDLTALDSIQALRKSDETLFELLELFSTENFDDFQDFKEGNGSFLEEQDLDEDILDKKMRLLTLASLSAAAHQSRTLPYAQIAKALQIPSSEVEMWVIDSIRSGLVEGKLSQQKQEFLIHRSTYRVFGDSQWREVASRLDVWKNSLQNVLAVIRQQKLDLIKEKEQEANTNANGERRGGYRPYNRAGGNQNDRREQSAIEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M3AYJ8</accession>
    <name>M3AYJ8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nexin_C-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_149245</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760743.1">
        <property type="nucleotide sequence ID" value="XM_016905439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AYJ8"/>
    <dbReference type="STRING" id="692275.M3AYJ8"/>
    <dbReference type="GeneID" id="27902576"/>
    <dbReference type="eggNOG" id="ENOG502RM76">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007315_0_0_1"/>
    <dbReference type="OMA" id="INGWIIH"/>
    <dbReference type="OrthoDB" id="41200at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000065">
        <property type="entry name" value="PX domain protein (AFU_orthologue AFUA_2G07450)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013937">
        <property type="entry name" value="Sorting_nexin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF47">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 122 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08628">
        <property type="entry name" value="Nexin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00313">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51207">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PXA" evidence="3">
        <location>
            <begin position="179"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="379"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="435"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="715"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="771"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="410"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="441"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="469"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="715"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="779"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="801"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="818"/>
            <end position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF12622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1080" mass="116689" checksum="B5D807D5AFA63111" modified="2013-05-01" version="1">MDDTRIDTPARAAKDGPVPLPADDAVDADEELPPQTTAPTAPTAPTAPTAPTIPTEPQSVTSSLQSFTDKALNFLSTASNETLGACLVGLCATTYMVLGRVGLVIIGVAGGVVLQATWDGTRSGRGDPAARLAEAERRREAGVDVVKRVLEWRSSSRAESHAEDSRIYASQALDYSSFEPETAAALDAFTTAVIKDYVHHWYNATIPGEETFPAICRRTFTAFMLSLSGHLQRKRAADSFLDFLTNASSILIVFLNELALALNASPSSRPEEAISAYLQLKPESSLAYMLDQDSQKIKLEEAAEEILQAYLDPKSYNCPPVHAFLKQVQAQLILGYSLTKCSEPSWINEWIVYALEESETTKEVMDLVDAGVEGRARVETRKVARKMGQEQEATSEEKSTSAAARRRTMSRAEEAMDEAMREAKRLTELMIEEDNRRAHQEQASQATPPNVADSTDASTQGIPTPTSSESDRDRQSEDSRSVAGSFVAGHSRQDHTSAPSTQFTSFDQIVPKVQPTALGASEIPIKRAPVLTLLNANISIFDDSVPGEKASIKAKPNNDLLIQIEPANSAFPGWMIVRKYADFETLHEVLRRISVITGTRFTEAHNELPKWKTHTKAVLRTELERYLADAVRFQTLAESEGMKRFLEKDQGLNKSPNGSKGFGWPTPDAFGKLGGDMMNVLTQAPKQVAGGVAQGGKTVFGGVAGFVGAVGNVGKKAGHSSTNLSRSTTNTSIDITGRGASSNRSSMQLAGQGFMTDSYLGTMDVGRESQESLRAMPESIHERKLSSASLRSEESRPVQAALSSRPASILSQNDSVQATTASPAASATHLPPTLEEAPSLDTVNLPPPPSEMPSDYASPVSPSRSRKSTDLRSAAHSLSMLQVADSGNVTASAIPVNASKVDTGAKQEPQRNVPLTDRETSVAVELMFAVISELYTLSGAWQIRKTLLTAAKTFLLRPGNPQIGTIRDLIQISLLDSNLSDAGLAHHIYKLRENTLPTPEELEIWARDYPEKTPEQKEELRIKARKLLVTRGMPQALTSVMGAAASGEALGKVFDCLQLPGVSRGLVFGLALQALRIITH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M3B1S1</accession>
    <name>M3B1S1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Golgi apparatus membrane protein TVP38</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Golgi apparatus membrane protein tvp38</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_148944</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Golgi membrane protein involved in vesicular trafficking and spindle migration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TVP38/TMEM64 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761868.1">
        <property type="nucleotide sequence ID" value="XM_016905244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B1S1"/>
    <dbReference type="STRING" id="692275.M3B1S1"/>
    <dbReference type="GeneID" id="27902381"/>
    <dbReference type="eggNOG" id="KOG3140">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041954_0_0_1"/>
    <dbReference type="OMA" id="YHDEFTD"/>
    <dbReference type="OrthoDB" id="166803at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000022">
        <property type="term" value="P:mitotic spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051076">
        <property type="entry name" value="Golgi_membrane_TVP38/TMEM64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549:SF1">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="127"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="241"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="12">
        <location>
            <begin position="145"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="22"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="319"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="344"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="363"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF13747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="403" mass="44745" checksum="CBAAF6696FE67013" modified="2013-05-01" version="1">MGDQEHYSSTARALASQYNDYSDDESNLAAPTFHRSNSHSPLWSRRSLDSTPRRPQRRRDKYLQYAEQYYTRGYSIWTHLSPLQRAGAIFFSIFFTVLAILAITYSHSIFQYLAPVAKRWRNAPGGWLILWLATFFVSFPPMIGYSTCVTTGGFVFGMTKGWLILSSATILGSTTSFLLSRTVLKNYVSDMTKKSAKFSALAMVLKHDGIKLLIMIRLCPLPYSFSNGAISTIPTVTWQKFMLATAIASPKLLLHVFVGRQLGVIAESGDKMSFGTKVVSYTTMVIGIGLGIGTGYLIYSRTVARAAVLEAEEAAAARGGNVRRSSGSVGGYTDDGDDADEEDARQRADVLRERQSDVSLHTTYEHDLERGYRDDFTDDEDATERDVFDAGDGETDDESKSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2022-12-14" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>M3B3P0</accession>
    <name>M3B3P0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_115653</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762498.1">
        <property type="nucleotide sequence ID" value="XM_016901187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B3P0"/>
    <dbReference type="GeneID" id="27898324"/>
    <dbReference type="HOGENOM" id="CLU_2198644_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF14377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="108" mass="12038" checksum="3022D3A75C02E539" modified="2013-05-01" version="1">MSSHILTACASHDLHCLLSPSRSTPPMRASGKHASLRHGAQMFILVADQLQLLTGLVEQEKIRQRTWSHRCEWPRRACSSAMLGDIGPNAESRVSVNDEAYSKKIEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M3B5V5</accession>
    <name>M3B5V5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_114314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763313.1">
        <property type="nucleotide sequence ID" value="XM_016901088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B5V5"/>
    <dbReference type="GeneID" id="27898225"/>
    <dbReference type="eggNOG" id="ENOG502T3NY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_505429_0_0_1"/>
    <dbReference type="OrthoDB" id="3647278at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="11"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="519"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="396"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF15192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="539" mass="59559" checksum="D937994C8AB64B07" modified="2013-05-01" version="1">MVSIVDPIGKRVIGSNPLGTQAATSPPETHLRGPENYDTPRSRDIFNVARRLEVSRPPVSPLQPPQRPCLLQQLLRLIGYGGNNNNKKKKKKKEKQPPRPEIRVMTIENFQTQRHTCQYQRTYNPTHRLLPEEHIAAWRKRQQHEREQISKNNNNISSKRQFHGPIPKRPNIDPLTIKNLSPLELEIYHTIRPIGRCATFTPFTPVTPFSSSTRREQIMLVHPTDLPHLQHIQNLVREISPRDKTCMVKSLEGLLIPQLVAVLKILLLTRPEVRVTSRSGEGEGGGAGKVGLRRPASWEIFAGGVRDSWEQVSVVSGGLGGAVEVEKGRMEDVVAAAAAGDLGGERGKGQRKKEKKRRIRDWWRSSKDQPPPQQQPLSIFKSFSQKEFMPELTLDSSASSSSSSSSSSSSQNKKNPPFQPHLRGGGGDASTNKEAKSTPLPFVRTARAYLGRSSCLNDAERVPRTLFLLAGGRVSPRMKAPTAGELRRRRQVERVNRREVGFVGTLFGVRRVCKVEGDGVGGGGGEIGADGGNGNGDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M3B6W8</accession>
    <name>M3B6W8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_80411</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763683.1">
        <property type="nucleotide sequence ID" value="XM_016910245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B6W8"/>
    <dbReference type="GeneID" id="27907382"/>
    <dbReference type="eggNOG" id="ENOG502RVY1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_842316_0_0_1"/>
    <dbReference type="OrthoDB" id="3633490at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF15562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="290" mass="32904" checksum="C4B7700DFC5A3D6A" modified="2013-05-01" version="1" fragment="single">MPKRRAASPDLTDRARKRLSLTALAAKASSSSLRHEQQGSFLNIFTPHTRIKRSDSIISRASSRPLLRPVPLQPGLTISGRGLQTHPDHDVASIKELLVYPTSLAMIKPSWIFRYTVNCTPQLGPALPDAVEHALYQKYIGARLHPRPEQLPYIHLGSTALGFRVDFYLILPFASTSSGHSGTGNMCSSDLQAVYDLCIRPAIETAYPRRQRWMSWIEAKNESHLKPLKSRRRSARSEPQEERVHCEGLRTLWDAIEVFSDHQDIAHIMRGRQLVAYGDVEVHDWQSDWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M3B6Y0</accession>
    <name>M3B6Y0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_147420</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763698.1">
        <property type="nucleotide sequence ID" value="XM_016904290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B6Y0"/>
    <dbReference type="STRING" id="692275.M3B6Y0"/>
    <dbReference type="GeneID" id="27901427"/>
    <dbReference type="eggNOG" id="KOG0849">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023524_1_0_1"/>
    <dbReference type="OMA" id="SHADPMI"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051000">
        <property type="entry name" value="Homeobox_DNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324:SF5">
        <property type="entry name" value="HEMATOPOIETICALLY-EXPRESSED HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324">
        <property type="entry name" value="HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="59"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="61"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="470"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="518"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="584"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="683"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="14"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="518"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="544"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="606"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="630"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="683"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF15577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="712" mass="77762" checksum="D3F1B252C24DB4AF" modified="2013-05-01" version="1">MADVMALPPPPVHQAQTPQDCKSSMASSTSPESIQRSNSVHNNNNASRRPPRKSTLTQQQKNQKRQRATQDQLMTLEVEFNKNPTPTALVRERIAQEINMTERSVQIWFQNRRAKIKNIAKRSIENGEDCDSIPESMRQYLAMQAYAPGKGLSPGMLGRGPGFGPFGSGGLMLNPDTTSSKVVIQHFHCCRSLSIGTWRRVGQSTMDLVIFYSPDKACVTYYINNDSAGYKIEYPFAWIKNITLEQGDVLAAAEGASQRSGGLIIELTRPPKFYMDSSGSGGFYECGDFTEDQQASQVLVHQLGGPSKVLSGQLAKLVSLEAYQNRHNVFDPNTFAVSAPVSPMGRPASQPNHMMHPHSGMHLFPPQDPHAGMMGPPGPRGHKRQRSRSVPAAIDFNMFRSGQMPMPSFLIQEENQPATVPMQDPNIFAPVPQHQIPQGFANGAGPNHLSIDTSQNYNSMGMPFNGPLSATTANSPSEFGTPGFFSQAPSGEGLQPTHFNPHMSNGFLTVDSGHMLGTSTTPLSMTSHGDPVIADHSPPLNGMGRSQSADIFGTPNESAQLGSDDLYLSESFNKQIALPFRSPMNEESFHSPMPEGMFNFQSPSSGNGQDGNMNGNGQQQMSYPSPSQQNGSNYQSPSGQHQDSGVSFSTPSHETSQENGMLYNESKMYTSPGQMQQLQDDMFQHQSPGNGFDMQSQQMFGFVDPNNLGQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M3B8J5</accession>
    <name>M3B8J5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Peroxin-10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">SEPMUDRAFT_147813</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF16177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764298.1">
        <property type="nucleotide sequence ID" value="XM_016904538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B8J5"/>
    <dbReference type="STRING" id="692275.M3B8J5"/>
    <dbReference type="GeneID" id="27901675"/>
    <dbReference type="eggNOG" id="KOG0317">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041707_2_0_1"/>
    <dbReference type="OMA" id="YCDVVQL"/>
    <dbReference type="OrthoDB" id="6270329at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016562">
        <property type="term" value="P:protein import into peroxisome matrix, receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16527">
        <property type="entry name" value="RING-HC_PEX10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025654">
        <property type="entry name" value="PEX2/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350:SF0">
        <property type="entry name" value="PEROXISOME BIOGENESIS FACTOR 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="20">
        <location>
            <begin position="341"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EMF16177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="392" mass="44266" checksum="B44425582BDE982E" modified="2013-05-01" version="1">MSDHIRDGGQSISGDPTRTFNYPWAAAPDIIRSNQKDAYFQSVLLTQLSAVIRSLYGTRSEHKWASEASLFTELLYLGLTTFIGNRTLGEEYCDIVQVEDDTHRLPSIARRSGYILSSVLLPYTLTRFLPAFRKRLRAKLEKRLKRAHHRRVSDSAQIKNPPKKVSQFQEYILKHLDSITSPAPVYAVSLAVFYFSGAYYQLSKRIFGLRYVFTRKLTEGDQRAGYEVLGVLLVVQMVVQGYLHMKTTYSNVQAQNLVPPPPTSSGLQAGGTAVVDEDVEAGAENPFNTPLLFESHPSGNSPEDIARRVAQTTHTPIIQGHRYDLKDDETMQWIGDQARKCTLCLEPMKDPSVTTCGHVFCWSCVTDWLREQPMCPLCRQGALVQHVLPLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M3BP25</accession>
    <name>M3BP25_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_55161</name>
        <name evidence="1" type="ORF">SEPMUDRAFT_55202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2012-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genome evolution in poplar pathogens from wild and recently domesticated pathosystems.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Dhillon B."/>
                <person name="Feau N."/>
                <person name="Sakalidis M.L."/>
                <person name="Gill N."/>
                <person name="Aerts A."/>
                <person name="Ohm R."/>
                <person name="LaButti K."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Copeland A."/>
                <person name="Beauseigle S."/>
                <person name="Grigoriev I.V."/>
                <person name="Goodwin S.B."/>
                <person name="Tanguay P."/>
                <person name="Hamelin R.C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456288">
        <property type="protein sequence ID" value="EMF07897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KB456278">
        <property type="protein sequence ID" value="EMF07913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BP25"/>
    <dbReference type="eggNOG" id="ENOG502S6ZB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_212881_0_0_1"/>
    <dbReference type="OrthoDB" id="7118285at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF07897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF07913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="49" mass="5810" checksum="07F279533C87D581" modified="2013-05-01" version="1">MPRHLISDAHEWINEIPTVPIYYLAKPQPRERAWQNQRGKKTLLSLTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M3BUN3</accession>
    <name>M3BUN3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_47419</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759165.1">
        <property type="nucleotide sequence ID" value="XM_016909033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BUN3"/>
    <dbReference type="STRING" id="692275.M3BUN3"/>
    <dbReference type="GeneID" id="27906170"/>
    <dbReference type="eggNOG" id="KOG0667">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_88_1_1"/>
    <dbReference type="OMA" id="QPYQDPL"/>
    <dbReference type="OrthoDB" id="9332038at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14212">
        <property type="entry name" value="PKc_YAK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000087">
        <property type="entry name" value="Dual specificity tyrosine-phosphorylation-regulated kinase 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000380">
        <property type="entry name" value="Serine/threonine-protein kinase ppk15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF17">
        <property type="entry name" value="HOMEODOMAIN INTERACTING PROTEIN KINASE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="277"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="612"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="669"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="790"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="10"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="68"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="635"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="681"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="840"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="857"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF11044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="866" mass="97657" checksum="B06A36332C371713" modified="2013-05-01" version="1">MDVDMDADPFNQQKYSRPPTNSSGLSSQYLPVHTQDDGSNRARYSPMNTSPTAFTSPPQQQQQQQQQLTPNPVQYTSYTPQQAARQSPHRQSQSQYASPTQQGRYYASPPASVRAHTNQLPPLQSNLQSPTSFYPQSATQQLNAVFGHDAPEPEKKTPQQQQQQQQSAHGNSTVPQFSRIYNAADLHCQVNAQPPFRRANPEGGFISPLQALTTHLPATYRICNPAFQYESSRNPRRVLTKPSKGVKNDGYDNEDSDYILYVNDILGSEETNHKNRYLILDVLGQGTFGQVVKCQNLKTQEVVAVKVVKNKTAYFNQSMMEVSVLDLLNGRMDKNDDHHILRLKDTFIHRQHLCLVFELLSVNLYELIKQNQFRGLSTTLVRVFAQQLLNGLCLLSKAKLIHCDLKPENILLKNLESPIIKIIDFGSACDERQTVYTYIQSRFYRSPEVLLGLPYSAAIDMWSLGCIVVELFLGLPLFPGSSEYNQVSRITEMLGLPPTWMLEVGKQSGEFFEKVHDEFGRRTYRLKSMEQYSREHGTKEQPSKKYFQQTRLPDIIRAYPMPRKGMKQNEMEREMANREAFIDFVHGLLNINPLERWTPQQARTHPFITQQKFTGPFQPRMDLKPTSRSPAPGVQQQQQAEALSRQRQQQAQAAQVQQAANAAYANAMHGMTPSYPTTPTAAQQQHQQQQQQQQQAAMYQNMYSPSQQGAPPPYPSNPPVQSAYGQQMPMIQQPPPVAGMNPYAQQPPQNLYAQATTRAGRQRASTMDGNGNVNGIPSALQRVVSHLDPNQPIRLQPSPAYYPPPQDGQSASDIGSIGSRRRASRAAGNGRQGTSGQERNFVRMLEDRTLEEGWNGKNAQWPGSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M3BVR4</accession>
    <name>M3BVR4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">BRF1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_150357</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIB family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759535.1">
        <property type="nucleotide sequence ID" value="XM_016906115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BVR4"/>
    <dbReference type="STRING" id="692275.M3BVR4"/>
    <dbReference type="GeneID" id="27903252"/>
    <dbReference type="eggNOG" id="KOG1598">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010293_0_2_1"/>
    <dbReference type="OMA" id="IVHEHEF"/>
    <dbReference type="OrthoDB" id="511529at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000126">
        <property type="term" value="C:transcription factor TFIIIB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000995">
        <property type="term" value="F:RNA polymerase III general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20554">
        <property type="entry name" value="CYCLIN_TFIIIB90_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000002">
        <property type="entry name" value="Transcription factor IIIB 90 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.650">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011665">
        <property type="entry name" value="BRF1_TBP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000637">
        <property type="entry name" value="HMGI/Y_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF4">
        <property type="entry name" value="TRANSCRIPTION FACTOR IIIB 90 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07741">
        <property type="entry name" value="BRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00354">
        <property type="entry name" value="HMGI_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Transcription factor TFIIB cyclin-like" evidence="11">
        <location>
            <begin position="119"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor TFIIB cyclin-like" evidence="11">
        <location>
            <begin position="226"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Brf1 TBP-binding" evidence="12">
        <location>
            <begin position="645"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="380"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="687"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="568"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="418"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="515"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="695"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="764"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="802"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="836"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="869"/>
            <end position="889"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF11414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="889" mass="97006" checksum="4A8247E5DAF7E157" modified="2013-05-01" version="1">MPGPVPRVRHGRIGGLKALPPRKRAPAKQAPATKTCPNKECGSTRFSEDDGKVVCLDCYTEIAENNIVAEITFEENAGGRATVQGGTVNDNSRHAKTLGSGAYRKVGGGERNSLADVQNAGRKALEQLCPKLGILPQVQVQAEQIWVLAANINFSAGRRTDEVVAACLYAACRRRKDNKVLLMDIAELLQINVFRLGEVYKDMCRELYLADENVGTQHMVELEPLIYKYCDKLQFAEKTKDVAADALKIIRRMNRDWIVSGRHPAGLCGACIILAARMNNFQRTVREVVFVSKVADVTIAKRVEEFRRTKASGLSVDNFRKYANKIVHQHDPPSFHNGDYNAQKFARAKARRKAHMEMLELRASQMRSPSAADIVIPDDMSETSSRLSSIEPGTPGPTEPVPGVQHVPDVAPMAVPASQGTDNAQQSDAAVNDSPQETSPPAQEGDASLVTTAQHSAKRKRNANVVSSSATPEPETAGEAGSPKRPRLEGSDPPESQTQQSRRVDADGFAIPEIPVRRTGREVPPEETAAPVKRGRGRPKKDPLQAPEIEISQEELAEEDYLETQIEEALQAREVQEVQSEVEKLKEAERIEAERMRAAAMAEAQEKFDTEKGRQERLARGVDYFGQAPDWTPGVILTAAELEAEFENDPEVNNCILSATEMKIKEQIWVAHNEDWLRKQAEKELLAKVEGANGSKKRKDGKGHKGRGKKRGTLGDGSVLTESSTPIETPADGVKAMLEKRAPMKSQHVDFSALQRIYGRETPSRASSATPGDSSGAQSPVTRAASAAPTETHDDDDDEEAAAAAAAAVAAASPTDEIVAHENPARYVQPATWLNMDEEGPTADVGGEEEDDEFEEDDEQTLLNLAAQGDDEFGAIYDEAYDGSGDEYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M3BXQ0</accession>
    <name>M3BXQ0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid permease 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_125932</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760982.1">
        <property type="nucleotide sequence ID" value="XM_016902023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BXQ0"/>
    <dbReference type="STRING" id="692275.M3BXQ0"/>
    <dbReference type="GeneID" id="27899160"/>
    <dbReference type="eggNOG" id="KOG1289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004495_0_3_1"/>
    <dbReference type="OMA" id="NIVAICW"/>
    <dbReference type="OrthoDB" id="10054429at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF10">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF12861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="616" mass="67173" checksum="99FAFEE807D09EAC" modified="2013-05-01" version="1">MFESLLALLPFTPYGKGYEHVSDHDDYPQTAGAVHRPGASYAHIPDQDDQTLARIGYQPELKREFGRWSTLSYAISILGVLGSQPATYGVPITVGGPATAVWAWFIGSCMAYIIASCVAELVSAYPTAGGMYFVPAKIVPQKHLPIWTWIIGWCNFLGQACGVASIAYTLGQMILAMKSMRSELVDGAYGYSPKPWQIVLIAIAMLFVFGCICSLTTKGLYRMVIWFAPINILATVGICIALLVLTEDKRDASFVFTDFRDGSGYGSKGWSFLLGFLNVAWVMTDYDGTTHMSEETHDAAVRGPASIRLAVVISGVQGFILNVVFTFCLTETYMDDIVGSPTGLPIAQIFLNAAGRDGATIMLFFVILIQFFTGAAAMLANSRMAYAFARDEALPLSHIWSRVNAQTGTPVYAVWFVAVFCAFLNLIGIGSTLTITAIFNLCAPCLDLSYIAVLIARLVYEDSEQFVPGPYKMGNYLGRFLPSKPRNIVAICWVLLISVVLFCPTTIPVTATNMNYAVAVAAAVAIFALAWWFLGANKYYTGPRLKNIEDITINTAAIAAHLADPSTIPNAEPSRSPPSYSSRRHSGPEQHDASSSSRRSSSRDETNMRYDKAHIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M3BYF8</accession>
    <name>M3BYF8_SPHMS</name>
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        <submittedName>
            <fullName evidence="7">Hydroxyisocaproate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_41981</name>
    </gene>
    <organism evidence="7 8">
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
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    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7 8">SO2202</strain>
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        <text evidence="1 4">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
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    </dbReference>
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        <property type="term" value="C:cytosol"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:NAD binding"/>
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    </dbReference>
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    </dbReference>
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    </feature>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMF13096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="333" mass="36615" checksum="0BCEFF508E79E294" modified="2013-05-01" version="1">MATAQSALLIGKITHARKEWEALSSLLQLKEYESGTREDFISRCKKGEYDDVVVIYRSNDSTVVTGPFDKELIEALPKSLKYITHNGAGYDNIDVPAATDRNIEISSTPIAVDEATADVALFLLLGALRRITIPFTNVRKDEWRGSNFTLGHDPKNKVLGILGMGGIGSAVAKRAKAFGMTIQYHNRNRLSEEKEQGAKYVSFDELLQTSDVLSLNLALNPSTRHIIAQAEFEKMKHGIVIVNTARGPIIDEAALVDALQAGKVYAAGLDVFEDEPAIHPGLLDDERVVLLPHIGTATWETQKEMEVLVLENLKAAVEGKGLITQIPEQKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M3BZA9</accession>
    <name>M3BZA9_SPHMS</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_155712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
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        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016907637.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.M3BZA9"/>
    <dbReference type="GeneID" id="27904774"/>
    <dbReference type="eggNOG" id="ENOG502S9TA">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_232763_0_0_1"/>
    <dbReference type="OMA" id="SETMPAH"/>
    <dbReference type="OrthoDB" id="5408302at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1496"/>
            <end position="1524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="1725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
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        <location>
            <begin position="1835"/>
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        </location>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="64"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
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        <location>
            <begin position="159"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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            <end position="439"/>
        </location>
    </feature>
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        <location>
            <begin position="448"/>
            <end position="462"/>
        </location>
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        </location>
    </feature>
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        <location>
            <begin position="854"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="864"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="882"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1074"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1132"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1212"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1228"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1246"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1267"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1329"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1353"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1379"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1400"/>
            <end position="1410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1506"/>
            <end position="1515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1798"/>
            <end position="1810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1861"/>
            <end position="1873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1932"/>
            <end position="1946"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF13396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1964" mass="210365" checksum="E9442B518B8DB173" modified="2013-05-01" version="1">MFDKARRPHQRASSKSTYIAATTATRPVHDPAPISPLQMTFDFELPPSPFEPTTPNTATSSARQLSDGWPAPSNSKSDSATRITSGESREAGWQAGESVGREAVDSAGGVAAAEEGGEGRGKQNTLLVRKQSVMSHRLSTNFAFDDLAPMPLPDTSMSRTKDERPKTAHGSHSDDPISGMKMEASLFPMRSDTPVLSQIPSPPLPSMNRSFIDSRDKPYSSQPPKSFATLKGNHSSPNLPGANGKTPVSVSRGPAPIYSNRALVPQASLQELAQSSKYSGSTARPSTHSSSRTAVYPGASTTIGMPYGATADSYPLPQHVKTRPKTLGVTSSVAGVIVPTHHTSSKTTSKSDSRKSVVSKKKGRLLNPMLLLQRRRSSQDPDAVEAERADREAQAQALARQRDVLASGVKIPPPDFDPRIKGKLVHDFSAPREKRHTFDENDMPSPPTMQQSFGNAQPSSPATFPPRHASLVNRGNRSPKEGQRRSTHTPIFVENLDENPESSKRVSSIHAENLENKEFLQRASKHSTATAHSQESAILPPFARRSQMLDPLQASYFQDEDSKRSSDPSSHKGYSSPPSNGGEISPVTARSSGHIAISPISAGPTSPYGSRPVSHLNPALADSNASKLSANDSWRKPATEKTLWPHSIALTAPPQNNSITEGSGDNLPVEATNSISDVQKPQYPVRGASITTPRSPGAPETLGALKLEANTASPSTQSVLDRTVDFSAPEQSPRLMQDAATFHTQQAQLKMVEKRASAAGHSRRSAAVPKKNASNASRFSFQFGGESAAQEQALEEKHRKIVSREITDPIVRATSPDEDDDNYFDEDAMDDMDELEMQASSFEQPRPMLHPQSKLGTISNAGTSQSSQYLQQARQALQQPDSDGESLYDDEVPQITDEKDLPYAEHPAFRAHSAMGGNSRHNSMMTDTPDGYWRDSTIDSYMRDSYNPAAAQSRVSRMNPALGSSGLNAGHSQDYLGALDRDSQRCSRPQPPNLGVSGQSQAFLATTTSAKPMLPHRDSGNSERNRAVSGFSFSTLGATPSSEQVDPLDQVHEASKVVGGQGQSAVDDDRPHASTGSLDMQTLSSQTTPKLASAQDDPQSSTSTNRWQISSTGDANQPGWQRDNSALADRFSSPSNKVNRNTSEAGTFNPLSTVSDTGFEYSARGANPPSPGKGQYDGGTAGPRISKGESDLQRIGSPSTKTRKNSSPPPNTSGLGLSNFTAFDFGPSLTSTTLASTVADASSSAGQPHNVLNANSPREDGRRPVSHTANATQKSNVTAVPCTDRDSQSGVVPDPRGRQIVPASSPPIHLKKASIATTSPVPPWKKSPETPQQGIGSPSVATTSHREQSEFVNAARPPSSNNANTMPPAAGMDVIGKSFAKESSESDSHDGKKGFHDGQDDMYFDDGNFGEDFDDGIPAASGFDEDAFDDDNFLYRPNANFNGPQGYGHRQKNSILSLESMGSDGPYPSFAVPNASKALARNSQLMLEDLPIQAPVDPKYIPQRNPSEDAKRLGLSDKAPPVPVSEGNPEALLRMQNSLQKYHAALAEAANRAASEGRFYRQPSVASTIASSVNKPNHVVTHLAVDAHSMRDDASMYSQNEDGGEIHMPFGNGKSAVDRSDTQLSHLSQAPEYSPRKMSFDFGFDQSAISDFGGYEDEDDDLVAAANAEVLASDDEGFYGQEFEFYGRPRANSIEAQAFNGGFFGPDGDDGLQRNKSSREPNLTPITERSEFSTRNSFVAGMAGFGPPSAGGYGHPSPAMSRLPITPLVEHDVISFDELRRLRAQTFGGSRRSDKSSSNRSSQHSLSLLSPTIDTSVGNSAGQGYVGNYSAQYGSNPGSGDASIPPGAKPLPLDAGFNFHDSPQSATSSNGNSFALDIDATPKRNTNSVTEPVTAKKAPPRMMSPTRPKSSHSRSGSAADSITYVQEPDSEGSGRPRWVLERRRTSEAGQLELVGREFVQGGWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M3C1J5</accession>
    <name>M3C1J5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="14">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SEPMUDRAFT_147980</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol III by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 18">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="14"/>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762302.1">
        <property type="nucleotide sequence ID" value="XM_016904630.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.M3C1J5"/>
    <dbReference type="GeneID" id="27901767"/>
    <dbReference type="eggNOG" id="KOG0261">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000487_3_0_1"/>
    <dbReference type="OMA" id="AVCPPYN"/>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02736">
        <property type="entry name" value="RNAP_III_Rpc1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02583">
        <property type="entry name" value="RNAP_III_RPC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.30:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.390:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035698">
        <property type="entry name" value="RNAP_III_Rpc1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035697">
        <property type="entry name" value="RNAP_III_RPC1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015700">
        <property type="entry name" value="RPC1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006336">
        <property type="entry name" value="PRK08566.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48446">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48446:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14 16" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="15">
        <location>
            <begin position="266"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMF14181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1484" mass="165477" checksum="A0707224C754ECAB" modified="2013-05-01" version="1">MELEDFATKEQVVDNVPKRIKSLQFGLLSPSDVIAQSVVNVADRNLYDLALTQGGPRTITKHGPLDGRLGTSAKNGQCGTCGQGLKECNGHFGHVKLALPCFHYGYLKRIIEAMNCVCKDCSRVLLPEQEKRNYLKALRRPGLDGLRKDVITKKISAECRKVKVCPHCGAYNGPVRKVAGHPIKMFHNKYAIYTNSNAKSKVKPPEMQAFEKTFEEAIKVDKEIERHMKRVADDLTPLRVLNILKKVPNTDVELLGMDPHSGGRPEYMIWTHIPAPPVAIRPSVAQETASTEDDITNKLGDIIQVSTLIAATIKAGQPLYKVMDMWEFLQVQIAMYIDGNLPGLGRDSAYGKAMRGFCQRLKGKQGRFRGNLSGKRVDFSGRTVISPDPNLAIDEVAVPSRVAVIMTYPERVTKHNYEKLKACVKRGDKVHPGANFVIKGRDKRRLVLKVVGQKGDLKKVADQLEIGDIVERHLEDGDIVLFNRQPSLHKLSILSHRAKIRPWRTFRLNECVCNPYNADFDGDEMNLHVPQTEEARTEATELMGVKNNLSTPKNGSPIIAAIQDFITGAYLISQKDRFFSRRHFTHVVGFMYNAMQAKDPYTGKEYPIVIPPPAIWKPQALWTGKQIWNLLIKPHPDYPVNVNLEARLKQYAPPTRPNDIPDMVDTDSYLVIRNSEVMCGGFDKATIGDGKKDSLFYVIMRDFGADYAAAAMTRLAKLSARWLGEQGFSIGISDVYPSEKLTKRKLNLVETAYRKCDEIIHKFKTGKLERSAGCDEEQTMEIMLSGILSKVRQECGDACFAELSKYNAPMTMAKCGSKGSNINVSQMVAVVGQQIIGGKRVLEGFQDRTLPHFLKASPDPLAKGFVFDSFFSGLTPTEFIFHAMSGREGLVDTAVKTAETGYMSRRLMKSLEDLSAQYDLTVRNSSGGIVQMKFGDDGLDPVDMEGNAKPINMDRTWSHSVESTWDNSEACLTKDEIETYTHTVLNKERAKLGRYTDDGQALEYADERAKSTDQLEYSRQFLDDVTNYVFTKTKKMTRSHEKLANSDAVFRITQSALQTFLHLCMLKFEKSKVEAGHAVGAVGAQSIGEPGTQMTLKTFHFAGVAGMSITQGVPRIKEIINASKVISTPVITCHLDSPYEDMAARFAKALMEKTYLGDIVDYVEDVWHANGCYINMRVNWQQIGNLGLRIGMEHLLDAIERTKGFKTLGVSARNSGYNHIRVNISLPEKERSRRQTSASKGRITESDGSELMFMQVHTLKRKLPEVVVKGYPDAHRAIIKKDDKKDRNGKEPISVFVEGYGLKQCMTTDGVDGYRTKSNNVMECRDVLGIEAARKTIIDEIDAVMGSMDIDPRHMQLLADVMTYKGEVLGITRFGLAKMRDSVLQLASFEKTPDHLFEAAAKMKKDDIEGVSECIIMGQSMSVGTGAMKVVRPLHLEGLENVASTLSFRAEVKSSTGTRKDRLKQRRTKLMPAMTNGHAVAAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M3C1T7</accession>
    <name>M3C1T7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_40793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762397.1">
        <property type="nucleotide sequence ID" value="XM_016908802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C1T7"/>
    <dbReference type="GeneID" id="27905939"/>
    <dbReference type="eggNOG" id="ENOG502RX42">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046066_1_1_1"/>
    <dbReference type="OMA" id="WHTPTHY"/>
    <dbReference type="OrthoDB" id="1263307at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052897">
        <property type="entry name" value="Sec-Metab_Biosynth_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017:SF11">
        <property type="entry name" value="ESTERASE_LIPASE_THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="35"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF14276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="272" mass="30223" checksum="1E6FFF5B7F0CC8A0" modified="2013-05-01" version="1">MATLYSSRSHSENTEKIAADITAVHKAQRPENWTVILVSGAWHVRFHCEPPTPYFKDAGYNYIPLPLPAAGGKTSTLEENLSAISSTIASELNKPGQQIAIILQSAAGLIGTEAINRILASQPSAAERIRIIYLAAIFEYGPIVTHLASAGHLRIDDKFESFWCDTGYEAFYRDDMTEAEAQPYVEALTFQKMIGATLNLSSEAWRACDLTSVVCLKDKVVPLEWRFKLAEEYGMRIVQMDTGHCPFVTRPREFAEMVDGVVREGMKTKTVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M3C1X6</accession>
    <name>M3C1X6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_40430</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762432.1">
        <property type="nucleotide sequence ID" value="XM_016908784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C1X6"/>
    <dbReference type="STRING" id="692275.M3C1X6"/>
    <dbReference type="GeneID" id="27905921"/>
    <dbReference type="eggNOG" id="KOG4727">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067237_2_0_1"/>
    <dbReference type="OMA" id="VDHRRKW"/>
    <dbReference type="OrthoDB" id="30343at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040107">
        <property type="entry name" value="Snu23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45986">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45986:SF1">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="162"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="18"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="172"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="185"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="198"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF14311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="214" mass="24642" checksum="012BB90D5F284649" modified="2013-05-01" version="1">MADRKGAYGASNGASDTSFRRTWDRSEYEAKARDRDAKIKEEGKARYEAALEGKKYHRRASTPTDHKDTEARQQRLNVAEQVGKTTLVAAGAGQGKRGKSAGFYCDACDLTFKDNLQWVEHLNSKQHLIATGESGEVRRATLEEVEERFDYLKRKLEAEKVHDQTDLQTRIKTTEEQLEKEREEKRRKRNEKRRKTKDGKGHEELRVENDGIIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M3C2E0</accession>
    <name>M3C2E0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF1014-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_162530</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC124 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762532.1">
        <property type="nucleotide sequence ID" value="XM_016908008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C2E0"/>
    <dbReference type="STRING" id="692275.M3C2E0"/>
    <dbReference type="GeneID" id="27905145"/>
    <dbReference type="eggNOG" id="KOG3223">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069723_1_1_1"/>
    <dbReference type="OMA" id="FEERMMP"/>
    <dbReference type="OrthoDB" id="76412at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010422">
        <property type="entry name" value="Ccdc124/Oxs1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054414">
        <property type="entry name" value="Ccdc124/Oxs1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054413">
        <property type="entry name" value="LSO1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21680">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21680:SF0">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06244">
        <property type="entry name" value="Ccdc124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22048">
        <property type="entry name" value="LSO1_2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LSO1/LSO2" evidence="5">
        <location>
            <begin position="7"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Coiled-coil" evidence="4">
        <location>
            <begin position="107"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF14411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="215" mass="23712" checksum="037515B063EDCB31" modified="2013-05-01" version="1">MPKTENTKKAAGNAKKAEAAAAKQAAEDQKRAAAESKEWSKGAKDNSKAAAAAEKQAEAARKKAEKEALLKEEEASLPSKPSKGKVAPKKSKGLDLSGLDAPSSKKELAALNATGIDNALDALSLTTDNKEKIDRHPERRFKAAYTQFEERRLEELKDEKGLRRQQKIDQIRKEFEKHPDNPFNQVAASYNMSKEEIAELREQQKKAKENLLTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M3C2P2</accession>
    <name>M3C2P2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_132168</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762652.1">
        <property type="nucleotide sequence ID" value="XM_016902477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C2P2"/>
    <dbReference type="STRING" id="692275.M3C2P2"/>
    <dbReference type="GeneID" id="27899614"/>
    <dbReference type="eggNOG" id="ENOG502SKB7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009555_1_0_1"/>
    <dbReference type="OMA" id="VMDVPIM"/>
    <dbReference type="OrthoDB" id="5327538at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF14531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="521" mass="57402" checksum="AB829F336C3060F6" modified="2013-05-01" version="1">MDCKQDKRSACALASKPSSAFSAISSAASATSAGTSRSGGSRLLFGEIDTSSDRSIESYASVCSFVLCDSSTFLKFWLEDKCRDRLLAFMPKQDLGNLRLACHDFSIRAAPALFSDLSITFRTNTFTKPSKLLALDRLGFYVKTLRFTLPHNQETFLPPLIEPETGAELSFTYTPQIQEHSSKRPKYGDAGTTQILSRQYPALFHAATNVPAFIRAFSAFINLEHLAISCPGYDSSLRYRKSIVDYGLISLRIAIEMNSLNALHALTISPIHPGGLLSLSPIIGFGASPRSASRWGRIRTLVIVAESIPHTAGAQEPDQFKLLQTYLRNFQSRLEVLSFRWIGQKGELPVARPPIATTAFFGQHPANQVAASKALRPLNFPRLKHMEVHNVATGAATISGFVAAHKVTLKELKFEGVELLQGTWDDALASMTKRSRRLPRNDIAEIPIMLSPSAGARSFPAPLERVEAEHYDADGQKSVRMAEWLSSKRKTTTVPKKLRDGLLGCEEQLRKVLRGSAFPWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M3C507</accession>
    <name>M3C507_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPI transamidase component PIG-T</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_147274</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763487.1">
        <property type="nucleotide sequence ID" value="XM_016904192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C507"/>
    <dbReference type="GeneID" id="27901329"/>
    <dbReference type="eggNOG" id="ENOG502S55X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062870_0_0_1"/>
    <dbReference type="OMA" id="EVRVCWL"/>
    <dbReference type="OrthoDB" id="3360032at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031501">
        <property type="term" value="C:mannosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019433">
        <property type="entry name" value="GPI_ManTrfase_II_coact_Pga1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28022">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2 SUBUNIT PGA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28022:SF1">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2 SUBUNIT PGA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10333">
        <property type="entry name" value="Pga1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004031624" description="GPI transamidase component PIG-T" evidence="2">
        <location>
            <begin position="21"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF15366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="227" mass="25280" checksum="FE9C69A68BBFBFE0" modified="2013-05-01" version="1">MMLPACLTALLALQVTTALANTEKLIFLAPAVITLPDTGPTLQALHLDTVSPKSPTLRKALAVAFPTQDRPRGLESWYLLEGLSAASRYEIRICWPAVQPTEFWLETYNVSHVFDTPALIQGLAAFAEQQVQPSADRELRRSQPLESLLFLKVQAAADYFTTNKTLMLRPQPVDIDIILDPYLANIFPASLLPTAIYIVGLAILSFYVSGWIWRTLQSQTLIKQRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M3C8G4</accession>
    <name>M3C8G4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyridoxamine 5'-phosphate oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_136966</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF08180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756301.1">
        <property type="nucleotide sequence ID" value="XM_016902819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C8G4"/>
    <dbReference type="STRING" id="692275.M3C8G4"/>
    <dbReference type="GeneID" id="27899956"/>
    <dbReference type="eggNOG" id="ENOG502S00X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078856_0_0_1"/>
    <dbReference type="OMA" id="HPTIIMT"/>
    <dbReference type="OrthoDB" id="5300823at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052841">
        <property type="entry name" value="PMP_oxidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28040">
        <property type="entry name" value="PYRIDOXAMINE 5'-PHOSPHATE OXIDASE YLR456W HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28040:SF1">
        <property type="entry name" value="PYRIDOXAMINE 5'-PHOSPHATE OXIDASE YLR456W HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="PNPOx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase N-terminal" evidence="2">
        <location>
            <begin position="22"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF08180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="244" mass="26295" checksum="CC8250214115406E" modified="2013-05-01" version="1">MPTTATTATAASWEPTVSENLPNEVVTCLRNARFLHLATCTDNVPHVSLMNYTYLPSRAFPPATSSHLPSGPTIIMTSNPSSKKTLNLLSNPNVSLLVHDWVSSRPPTNLSGSDRERSPSGGPRSSLAAMLMQMNSTAVSSNSITINGEAMLLEPGSEEEKWCKEQHISNNTFEQDGLSPLSLQQSRGDDTGDSGKGAYIEGEHVRVVVVRIKDGRISDWKGNVSDWTLSSEAVDTDRAVVNGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M3C8U4</accession>
    <name>M3C8U4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycosyltransferase family 62 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_151987</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the ANP1/MMN9/VAN1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756416.1">
        <property type="nucleotide sequence ID" value="XM_016907172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C8U4"/>
    <dbReference type="STRING" id="692275.M3C8U4"/>
    <dbReference type="GeneID" id="27904309"/>
    <dbReference type="eggNOG" id="ENOG502QVDT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017872_4_2_1"/>
    <dbReference type="OMA" id="WVESDKG"/>
    <dbReference type="OrthoDB" id="204164at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000017">
        <property type="entry name" value="Mannan polymerase II complex ANP1 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052086">
        <property type="entry name" value="Mannan_Polymerase_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083">
        <property type="entry name" value="MANNAN POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083:SF4">
        <property type="entry name" value="N-GLYCOSYL-TRANSFERASE (AFU_ORTHOLOGUE AFUA_4G06870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03452">
        <property type="entry name" value="Anp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF08295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="405" mass="45836" checksum="5DBAE065027FDD11" modified="2013-05-01" version="1">MLLPKGTGMTWKSARARLPPSRAIWNFLTRTRFLLFVAIAGIIILIWNGVRGSAGDFQKFYCFGPAKSPMQMTPNEQAQWAGHLQTPVIFNHHEPIEINSSSIQHIDLNPITSTPKALANEEHVLILTPLRNAAPYIEQHFDLLTQLTYPHKLIDLAFLVGDSTDDTLAVLSMELERIQSRTDSIPFRSVMIVSKDFDVAASQDVESRHGFAAQGPRRKAMGKARNYLLSAALKPEHSWVYWRDVDIKDSPSRIIEDFVAHDRDILVPNVWFHRYENGRDIEGRFDYNSWQESEKGLKLAASLDKDVVLAEGYKEYDTGRKHMARMGDWRDNKDVEIPLDGIGGVNILVKADVHRAGINFPCYAFENQAETEGFAKMAKRAGYGVYGLPNYVVWHIDTEEKPGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M3CC04</accession>
    <name>M3CC04_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_151029</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF09937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758058.1">
        <property type="nucleotide sequence ID" value="XM_016906549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CC04"/>
    <dbReference type="GeneID" id="27903686"/>
    <dbReference type="eggNOG" id="KOG0253">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_52_1_1"/>
    <dbReference type="OMA" id="VFRFHES"/>
    <dbReference type="OrthoDB" id="4139357at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="395"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="443"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="557"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="85"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="340"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="340"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF09937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="586" mass="63736" checksum="52A79AD4ECE00F74" modified="2013-05-01" version="1">MASEKDITYPPAEAADNGSTSGNPQSQQHVDETLAQLEDPSSTQLSIRAILQGNATHPLTAFEKKAALINVELDSFGLGRYQICIWFLCGFGYFLDLAWSQGVGLAATAIYQEMNVPDGQTGKIYSLANAGLAVGAFSWGILVDIIGRKWAFNLTCLITSVFGLILAAPKFNYNAICGIYFLASIGLGGNIPIDATIALEYLPQNRRNLVTLLSLWQPIGVVFASAVAYGTAAKPSWRCNDSLPSCVTIPDGEARNSSTCCTVDSNMGWRYLFIILGVMTLVIFFLRYFIFHLYESPKFLLSHGREQEAIDVLHKIAYFNKAPPPTLTLEMFQAIDETSSPSSSSSVVGGVASDSQQLATRGEKLSTARKTQKVLRNFARGLGNLKALFSNPLQAFIFILLAIAYMGDYWSFNLAGSFLPIILLRNEVSDGSGSVAETYRHYIYIYLPGILGAILGLVSVQLPLVGRKWSLVISAILQGVAMAMYTQVYTTAGYVGLNAFEYVMQTYFNAVLYASAPELFDTSYRGSASGMLSCLGRISGIVAPFAGQHYLSSNSSGVLWLGAGGIWLSALTMVFLPVEMRNRQMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M3CDU9</accession>
    <name>M3CDU9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Prephenate dehydrogenase [NADP(+)]</fullName>
            <shortName evidence="9">PRDH</shortName>
            <ecNumber evidence="9">1.3.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_150196</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>prephenate + NADP(+) = 3-(4-hydroxyphenyl)pyruvate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21640"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="ChEBI" id="CHEBI:36242"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8 9">Amino-acid biosynthesis; L-tyrosine biosynthesis; (4-hydroxyphenyl)pyruvate from prephenate (NADP(+) route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the prephenate/arogenate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.13" evidence="9"/>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759317.1">
        <property type="nucleotide sequence ID" value="XM_016906013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CDU9"/>
    <dbReference type="STRING" id="692275.M3CDU9"/>
    <dbReference type="GeneID" id="27903150"/>
    <dbReference type="eggNOG" id="KOG2380">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031403_1_0_1"/>
    <dbReference type="OMA" id="WRVNACD"/>
    <dbReference type="OrthoDB" id="5399569at2759"/>
    <dbReference type="UniPathway" id="UPA00122">
        <property type="reaction ID" value="UER00962"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008977">
        <property type="term" value="F:prephenate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004665">
        <property type="term" value="F:prephenate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3660.10:FF:000002">
        <property type="entry name" value="Prephenate dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3660.10:FF:000004">
        <property type="entry name" value="Prephenate dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000339">
        <property type="entry name" value="Prephenate dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3660.10">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046825">
        <property type="entry name" value="PDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050812">
        <property type="entry name" value="Preph/Arog_dehydrog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003099">
        <property type="entry name" value="Prephen_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012385">
        <property type="entry name" value="Prephenate_DH_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21363">
        <property type="entry name" value="PREPHENATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21363:SF0">
        <property type="entry name" value="PREPHENATE DEHYDROGENASE [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20463">
        <property type="entry name" value="PDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036510">
        <property type="entry name" value="PDH_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51176">
        <property type="entry name" value="PDH_ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0521">NADP</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0827">Tyrosine biosynthesis</keyword>
    <feature type="domain" description="Prephenate/arogenate dehydrogenase" evidence="11">
        <location>
            <begin position="4"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="293"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR036510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF11196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="460" mass="51664" checksum="00EC14F5DDF7EC13" modified="2013-05-01" version="1">MGDAVVGIIGMGDMGKMYARRIADAGWKVHACDVPDKFEALKAEFASRKNVTIFENGHYVSRSSDWIMYSVEAKNIDAIVARYGPSTKMGAIVGGQTSTKAPEIAAFEKHLPADVEIVSCHSLHGPGVNPKGQPLVIINHRASQKSVDLVEKILSCFESTFVPLSAEKHDRITADTQAVTHLAFLSMGTAWCANDQFPWEVPRYIGGIENVKINLMMRIYSNKWHVYAGLAILNPAAKAQIRQYAESVTDLYKMMLSGQTEQFSERIYAARDAVFGADAGTKKQKKKSSSGGNDDEEETEEEEELLLEDELLDKFSLGDKPQQRVKNNHLSLLAIVDCWWKLGIVPYDHMICSTPLFRLWLGITEYVYRSPSLLSECIDTALHDVSFRADDLEFTFAARDWSECVQLGHMDGYREKFEKIQKYFAPRVEDATKVGNEMIKTIEANLKEKRMRKKGEEARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M3CGE6</accession>
    <name>M3CGE6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Carboxylase:pyruvate/acetyl-coa/propionyl-CoA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_149401</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760984.1">
        <property type="nucleotide sequence ID" value="XM_016905530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CGE6"/>
    <dbReference type="STRING" id="692275.M3CGE6"/>
    <dbReference type="GeneID" id="27902667"/>
    <dbReference type="eggNOG" id="KOG0369">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000395_3_2_1"/>
    <dbReference type="OMA" id="KGDAWSI"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000003">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45007">
        <property type="entry name" value="CARBOXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G07570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45007:SF1">
        <property type="entry name" value="CARBOXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G07570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0092">Biotin</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="10">
        <location>
            <begin position="11"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="9">
        <location>
            <begin position="125"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="8">
        <location>
            <begin position="590"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="510"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="521"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF12863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="680" mass="74210" checksum="7807D277F8027326" modified="2013-05-01" version="1">MTTDRIIEPRPIKKILVANRGEIASRILSSCRELNLETYAVYTANDALHTYNASHAIQLPSPASYMSISELKSIVQKHNIDAIHPGYGFLSESADLAAQMAAIDVIVIGPGSATLERTGDKLQARQLAEECHVPVLPALTQPTASVESVRNFAERNGFPVMIKAVDGGGGRGIRLVREMSELERLVHRAIEESPSKQVFAERAAVEGFRHVEVQIVGDGRGGVRHLWERECSIQRRYQKIVELAPSMCLDREVVRPVIEAAVRIATKVKYASLGTFEFLLNPRTKEFFFLEINPRLQVEHTITESICSIDIVKAQLRLAQGASFDEAGLGDLAEDPMLPPKQHSIQLRVTAEDAEKNYSLSIGKIQAFHLPSGVGTRVDTALIPGASAVVTSDFDSVIAKIIITARTWPDTVSKARRALEDTFITGVQTNLALLRAIVSHPDFEAGECDTTWLESKHDELLALSREMQRSSKDPFHGLVQLQQSISSSATAASSGGGGGSTTFRKDDAWTIDISSPDSPKKTQQQQKQQQQESQTHHLQLTKVLKNDFPSSFSANILYTISSSTTTSSTPLPLKISLTSTSASSSAMSSHHRYGTPSNPTHIIMPLSGKLVEVLVDGGDVVRKDEAICVIKQMKMEIEVRSHRAGVVTWVTEAEDGEDVAEGMLAAVVEDEKVKVGGSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M3CGT8</accession>
    <name>M3CGT8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Metallo-hydrolase/oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_43986</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-beta-lactamase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF13028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761149.1">
        <property type="nucleotide sequence ID" value="XM_016908912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CGT8"/>
    <dbReference type="STRING" id="692275.M3CGT8"/>
    <dbReference type="GeneID" id="27906049"/>
    <dbReference type="eggNOG" id="ENOG502S1A6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030571_1_0_1"/>
    <dbReference type="OMA" id="PCSHADS"/>
    <dbReference type="OrthoDB" id="10250730at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07730">
        <property type="entry name" value="metallo-hydrolase-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051013">
        <property type="entry name" value="MBL_superfamily_lactonases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978:SF5">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978">
        <property type="entry name" value="QUORUM-QUENCHING LACTONASE YTNP-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="5">
        <location>
            <begin position="55"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF13028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="389" mass="43080" checksum="CDB33E8B14AD0672" modified="2013-05-01" version="1">MSYNDPNPEQAPPIGLPKGSTACEVSIINTTCDLVVPPGTLIEPHIDGHEWLNLPTYSFLITHPSGAQVLFDLGCRKDWENLVPEVKEVVSQRVPGFKVQMEVPDILRAGGVNVDKLKALILSHWHFDHCGNISRLHPSTDLIVGPGFKAAFEPGFPQKATSVFYEEDFQGRNVIEPSFSDGLLLGRYQAHDYFSDGSLYILNVPGHTTGHISALVRTSPDTAIFMGGDVCHFPGVIRPSSFMPMPDPLPKETVLDSRFHHPCPCITFTACHPNPAESRTTPFYCCSSDKSRSWYEDPPTAMESIHKLLDFDADPNVLVLIAHDAAPLDVLPFFPDGNINDWQQKGYKQKMHWHFVNELPVDGKAGREPLTDGLYIGGKRMKTLDGEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M3CKN6</accession>
    <name>M3CKN6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-N-acetylglucosamine diphosphorylase</fullName>
            <ecNumber evidence="3">2.7.7.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_148077</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N-acetyl-alpha-D-glucosamine 1-phosphate + UTP + H(+) = UDP-N-acetyl-alpha-D-glucosamine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="2.7.7.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.23" evidence="3"/>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762454.1">
        <property type="nucleotide sequence ID" value="XM_016904686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CKN6"/>
    <dbReference type="STRING" id="692275.M3CKN6"/>
    <dbReference type="GeneID" id="27901823"/>
    <dbReference type="eggNOG" id="KOG2388">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025603_1_1_1"/>
    <dbReference type="OMA" id="YFQVDNP"/>
    <dbReference type="OrthoDB" id="532420at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04193">
        <property type="entry name" value="UDPGlcNAc_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000075">
        <property type="entry name" value="Probable UDP-N-acetylglucosamine pyrophosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039741">
        <property type="entry name" value="UDP-sugar_pyrophosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952:SF2">
        <property type="entry name" value="LD24639P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952">
        <property type="entry name" value="UDP- GLUCOSE PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="84"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF14333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="513" mass="57190" checksum="71483E6445FF7CB2" modified="2013-05-01" version="1">MDAIKDTMNKLASSLHIGGGQQEPVAEAPSEQEFKDLKDAYEKAGQGQVFTFWDELKPQEQGELYQQAKSIDPQNINKITEQTLHPAKSANDDKKAELEPLPESATTSTIDSNETDLKKWYDSGLQLISEGKVGVVLMAGGQGTRLGSSAPKGCYDIELPSHKSLFQLQAERIWKLQNLASKIHSKEEVTIPWYIMTSGPTRKPTQQFFEEKKYFGLNRNNVVFFEQGVLPCISMEGKILLESKTKIAVAPDGNGGLYNGLINAGIVRDMEKRGVKHVHAYCVDNCLVRVADPTFIGFSAEKQVSIATKVVRKRNAKESVGLILQKNGKPDVVEYSEIDNETAEAKDSKDSNLLKFRAANIVNHYYSFEFLDSIPQWSHKLPHHIAKKKIPTVDEKGNAVKPEKPNGIKMEQFVFDCFPFLEMNKFACMEVKREDEFSPLKNAKGTGEDDQDTSRKDILLQGKRFLEEAGAVVVSEKQGEGVEVSPLISYSGEGLEFLKGREIKAPAVIEKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M3CLI7</accession>
    <name>M3CLI7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Arsenical-resistance protein ACR3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_83142</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <topology evidence="1 9">Multi-pass membrane protein</topology>
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    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.</text>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015105">
        <property type="term" value="F:arsenite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046685">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1530.20:FF:000009">
        <property type="entry name" value="Arsenite transporter, ACR3 family"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004706">
        <property type="entry name" value="Arsenical-R_Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00832">
        <property type="entry name" value="acr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43057:SF1">
        <property type="entry name" value="ARSENICAL-RESISTANCE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43057">
        <property type="entry name" value="ARSENITE EFFLUX TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005508">
        <property type="entry name" value="Acr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0059">Arsenical resistance</keyword>
    <keyword evidence="4 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="121"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR005508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF14658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="329" mass="36195" checksum="95C520CEC4686CE5" modified="2013-05-01" version="1">MALGIILANLVPSTGPALQRGEFVGVSVPIAIGLLVMMYPILCKVRFETLHLLLKEKELWRQIAISFVLNWIIAPLYMTGLAWAFLPDRRELRDGLIYVGVARCIAMVLIWTDLAGGDGDYCAVLVAFNSILQIVLFAPMAVFYTHVVSGSPTSTTKAGSNLYSKAATSVAVFLGIPLGAAVVTRLVLRYLLGERNYQLYFIRFIAPWSLIGLLYTIVVLFGSQGLHVVQQITSVLRVCAPLLVYFLTIFPMTAWAMWRAGFGYKVSCTQSFTAASNNFELAIAVVVAVYGAGSQEALAATVGPLIEVPVLVALVYVIKWCQKRWNWYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M3CMU8</accession>
    <name>M3CMU8_SPHMS</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_147097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016904078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CMU8"/>
    <dbReference type="STRING" id="692275.M3CMU8"/>
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    <dbReference type="eggNOG" id="ENOG502QWJA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044616_1_0_1"/>
    <dbReference type="OMA" id="IQLFDWS"/>
    <dbReference type="OrthoDB" id="8064436at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014751">
        <property type="entry name" value="XRCC4-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42067:SF1">
        <property type="entry name" value="MITOTIC APPARATUS PROTEIN P62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42067">
        <property type="entry name" value="YALI0C15378P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58022">
        <property type="entry name" value="XRCC4, C-terminal oligomerization domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF15133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="384" mass="41978" checksum="EBB2649A5070AC03" modified="2013-05-01" version="1">MSPPTQHVLRLRRTDDKSAKHMLVNIAKEGRKDLDLKLIGTDQSELFVVSFKEADTKAYQDRNFKGNLEEWKTLLMFALLHHKPEGLLPDSLQGVETVAAISKTNATITIRKKVGEITQRLGTIPLQKTDTEVDTLEWVDAAAAEADGLRLQLDVLRASVESQRDSIAKLTTELDMLVRAKKAHEDELLSKFAALLNAKKLKIRDQQRLLKSAKIDSDAAIDVSRSKSASTPREASSSRGGKRKANGASLSPLTDSDAADEDGATVNGFDKGEGEGEGEGASRHDRVTPEPDEPDAAVEPVEDEEEHAASPEVLAGSGASHRVTQEQTQRRQPSQESDPMDVDEAAPTRQAPTRDMPPKTKEKEPTPPKASNIGDDEDETDDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>M3CNW5</accession>
    <name>M3CNW5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_123759</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763584.1">
        <property type="nucleotide sequence ID" value="XM_016901860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CNW5"/>
    <dbReference type="GeneID" id="27898997"/>
    <dbReference type="HOGENOM" id="CLU_2442272_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF15463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="90" mass="10017" checksum="6AF9E1D3F90305DF" modified="2013-05-01" version="1">MLILGAEDCYYNLIRPVWKRPTDSELDGHVFVPAALAHTCECEIRACDLAAGLRPAGMNQGSVNKARWTPSVWDNTVRRFSRLRSAKADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M3CXK0</accession>
    <name>M3CXK0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_111740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756507.1">
        <property type="nucleotide sequence ID" value="XM_016900934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CXK0"/>
    <dbReference type="GeneID" id="27898071"/>
    <dbReference type="HOGENOM" id="CLU_960319_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF08386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="290" mass="31623" checksum="C68C773A157AB611" modified="2013-05-01" version="1">MDAKQNSLLSQLGLLAVNVIATTRSTLAALELVSLSHFHGECSKHALNCLTDRRPVLRPVDDGATTGSVGNPSVPGQMREGRPIIWPKSKPVPMCLGSSRVTPLRTRDPPSRHQFSADDGTLPPTYDELKRWIAGSSLSSPASFTSGPVDTTGHWALGTVHIDVRQARAVHATTHADHLASAALLTLAPAARRVVWPVVWREKTRDRCGSGAVEHRPIGCIGLSVSARVSAAAAHNRQRTGHGDARKKATRHRTSRSKQNKRDTSPHGNGLMKSWNVSNWDRMRYRCDKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>M3CXV6</accession>
    <name>M3CXV6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_151807</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757023.1">
        <property type="nucleotide sequence ID" value="XM_016907057.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.M3CXV6"/>
    <dbReference type="GeneID" id="27904194"/>
    <dbReference type="eggNOG" id="KOG0519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002763_0_0_1"/>
    <dbReference type="OMA" id="EVIPQPC"/>
    <dbReference type="OrthoDB" id="303614at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000023">
        <property type="entry name" value="Sensor histidine kinase/response regulator, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.40:FF:000083">
        <property type="entry name" value="Sensor histidine kinase/response regulator, putative (AFU_orthologue AFUA_4G00660)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF72">
        <property type="entry name" value="OSMOSENSING HISTIDINE PROTEIN KINASE SLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="550"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="1122"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="237"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="330"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="423"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="825"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1016"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1089"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="237"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="252"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="845"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1109"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="1217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF08902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1298" mass="142983" checksum="06201F578EA18C38" modified="2013-05-01" version="1">MSSTLQEREIHRYYQPWLAAHGSSLNVANHVESLAQWDLQKQGYQPKTSRDKAITAFTQIVALRLNVSRCMVSLIDANNQYVLAEATKDVGTPAEELWLGSAILSRTDAVCEHTFINTCSAPEEDGRLYHTKGMIVNDLRLDERFKDFPYVVKKPGLRFYAGVPLYSRNGYMIGAIAVADDQPRNGLMADQLRFMQETAQGVLEHLEWARDRVDRFKGERIVRGMASFIEECGSIREGTRREESSEVRSEAGQRSTSAERTPKSSPNAKQTSRASLTGKNSARRVPLARHRTIHKADGMSRMFATAAEILRESTLADGCAIFGATADNGRTSIRATPHNLDGVTEKSAGTVYGQPSPESSSENGGHDTNTSDSDSSPAARPCKILSFAVADEQARGDIESGSALTLATLERYFALAPQGKTYSFNEEGSGASSEEESDVPSVTEAGNDVNCLGDVNNVTSRARPRKRRIMDHKELLKKIPGAKTVIFLPLYDDAEEKLIAGAFLWTSVTGRMLQDSDLSYLRAFGNCIVSEVVRMNMQRNEAAKTTFIASMSHELRSPLHGILGAAEFLMDTATDSYQSGLVTSIVTCGRTLLDTLNHVLDYSKINKLGRTQMKKRAKQNKPVNLASDSTLESMNLTADVDLGVLVEEVAEAVNAGHTFKHLPDLTNAHRHGATEYDSLTNHGPETEKDRPAARRVTVLLDISPRRSWLVRIQPGALRRIIMNLLGNALKYTSSGFVAISLRAQESTDKSNTKALIRVVDSGKGMSESFLRDRLFVPFSQEDPFQPGTGLGLSIVKQIVDSLGGQIEVRSEVGVGTEVDVTLSLPPATGATLPKAPGKGTAAADGKSRDAYDDPGLFDREMLEVEQKTRGRHLVLLNPARALQPLTSAASRFQQTLREIAINWFGMHVTYSTEMNVRDADIYVFCEPPPVEMMRAQNRKTLANADQTEAGYGEREVPIIIMCMNDQDALEISRNHQSTLRELGRVAEVISQPCGPRKLAKAFLHCLRRMEDLKNATPTEVREAGARAHDEAVLNDDHAGTTHDTEGHRPRQQSDDLRNSVSMAVSYPAAPPFDPTTPSLQSPPIEQQAVVKELHQSGDGESTPKASDVNSKDSMEPARRAPHLLLVDDNKINRQLLVMFMKKCNFTYREAENGQEALDQYQDSLEQATTDTWADTEMSGFEEAVANAHQNRKDSNCSNGTSTSTRSKPAPFDFVLMDISMPVMDGMEATRRIREFEKDQGLKKTTVIALTGLASEGAREEAETVGIDVFLPKPVKFKELRSLLEMRSRGEIKATVARN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>M3CY06</accession>
    <name>M3CY06_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 17">Glutathione reductase</fullName>
            <ecNumber evidence="3 17">1.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">SEPMUDRAFT_159425</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 17">Catalyzes the reduction of glutathione disulfide (GSSG) to reduced glutathione (GSH). Constitutes the major mechanism to maintain a high GSH:GSSG ratio in the cytosol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="14">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.7" evidence="3 17"/>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756687.1">
        <property type="nucleotide sequence ID" value="XM_016907845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CY06"/>
    <dbReference type="STRING" id="692275.M3CY06"/>
    <dbReference type="GeneID" id="27904982"/>
    <dbReference type="eggNOG" id="KOG0405">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016755_2_2_1"/>
    <dbReference type="OMA" id="MSKHYDY"/>
    <dbReference type="OrthoDB" id="5956163at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000003">
        <property type="entry name" value="Glutathione reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000141">
        <property type="entry name" value="Glutathione reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006322">
        <property type="entry name" value="Glutathione_Rdtase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046952">
        <property type="entry name" value="GSHR/TRXR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01421">
        <property type="entry name" value="gluta_reduc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004776">
        <property type="entry name" value="PRK06116.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737:SF2">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 17" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 14 16" id="KW-0274">FAD</keyword>
    <keyword evidence="6 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0520">NAD</keyword>
    <keyword evidence="8 17" id="KW-0521">NADP</keyword>
    <keyword evidence="14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11 16" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="19">
        <location>
            <begin position="98"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="18">
        <location>
            <begin position="441"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="543"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="272"/>
            <end position="279"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="15">
        <location>
            <begin position="135"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00056905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU365016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EMF08566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="554" mass="60786" checksum="06A991621103C458" modified="2013-05-01" version="1">MDHLPRAWMYIGMSRGDPNVISLCSKTKTAKLPSSTTYIIPPPALAAAKVSQQTPLRLYASASTAFRTASNQRLRLHAFSRHFSATAPIMAPIEKECDYLVIGGGSGGLASARRASGMYGAKTIAVENKRLGGTCVNVGCVPKKVTWNAAAMAETIKEAHNYGFSVQQTAPFDWPLFTKKRAAYIKRLNGIYEKNLKNDKVEYLHGTASFKDQHTVSVKLDDESEVSIKAKKILIAVGGHPSIPDVEGAEHGITSDGFFELEQQPKKVAVVGAGYIAVEMAGMFHALGTETHLFIRHDKFLRTFDPMVQEKVVQEYERQGIILHKNSKQTKLEDLQTGGKRLTYTDDNGDGILDVDTVLWAIGRAPELERLNIDASGVKLNEKKHIPVDDYQNTNIPHIYALGDVCDKQYELTPVAIAAGRRLSDRLFGGKEDAKLEYDNIPSVVFSHPVVGSIGLTEPQAREKYGDDNIKIYQASFTAMYYSMMEPEDKGPTAYKLICAGKEEKVVGLHILGTGSDEILQGFGVAIKMGATKADFDRCVAIHPTSAEELVTMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M3CZ99</accession>
    <name>M3CZ99_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_120877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757107.1">
        <property type="nucleotide sequence ID" value="XM_016901643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CZ99"/>
    <dbReference type="STRING" id="692275.M3CZ99"/>
    <dbReference type="GeneID" id="27898780"/>
    <dbReference type="eggNOG" id="ENOG502SQG8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035845_0_0_1"/>
    <dbReference type="OMA" id="NEDARMV"/>
    <dbReference type="OrthoDB" id="5315820at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF08986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="296" mass="30718" checksum="423AEDF87AF59ED6" modified="2013-05-01" version="1">MSSGPTLMNLPPPPSDPQTPSEVPSRSGTPNSTMTSMSELSTVAIKDGHRGHPPHQQHHQGPSGLSNQLDAERADRISRLAGLERVTTARNPPTPNSAGNLTPGGYQPQAHPTVSYFDATGNPTMGRERSTVGSASATGSVGARTTWAGSDAGMGDFDKMSESQDMDMDASSVGGMSDADRDTGSLVAFGEGARTPARQSTAGSAFPPPTSLPSSRGGPASTPTGIPSRFIDGMTYDEGVVDTTSNRDGRSGGQQEAERIMRENMDTTSDDRMGTSGSNMGKQQGPGDLGKFGFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>M3D0L8</accession>
    <name>M3D0L8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="18 19">Pyruvate carboxylase</fullName>
            <ecNumber evidence="6 19">6.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="29" type="ORF">SEPMUDRAFT_151080</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29 30">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.</text>
    </comment>
    <comment type="function">
        <text evidence="3">Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17 19">
            <text>hydrogencarbonate + pyruvate + ATP = oxaloacetate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20844"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 19">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="6.4.1.1" evidence="6 19"/>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758134.1">
        <property type="nucleotide sequence ID" value="XM_016906585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D0L8"/>
    <dbReference type="STRING" id="692275.M3D0L8"/>
    <dbReference type="GeneID" id="27903722"/>
    <dbReference type="eggNOG" id="KOG0369">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000395_1_1_1"/>
    <dbReference type="OMA" id="AEACICY"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004736">
        <property type="term" value="F:pyruvate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07937">
        <property type="entry name" value="DRE_TIM_PC_TC_5S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000003">
        <property type="entry name" value="Acetyl-CoA carboxylase biotin carboxyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000018">
        <property type="entry name" value="Biotin carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000010">
        <property type="entry name" value="Propionyl-CoA carboxylase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.600.10:FF:000002">
        <property type="entry name" value="Pyruvate carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000033">
        <property type="entry name" value="Pyruvate carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000012">
        <property type="entry name" value="Pyruvate carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.600.10">
        <property type="entry name" value="pyruvate carboxylase f1077a mutant domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003379">
        <property type="entry name" value="Carboxylase_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055268">
        <property type="entry name" value="PCB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005930">
        <property type="entry name" value="Pyruv_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006761">
        <property type="entry name" value="PRK09282.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009554">
        <property type="entry name" value="PRK12999.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01235">
        <property type="entry name" value="pyruv_carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43778">
        <property type="entry name" value="PYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43778:SF2">
        <property type="entry name" value="PYRUVATE CARBOXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02436">
        <property type="entry name" value="PYC_OADA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001594">
        <property type="entry name" value="Pyruv_carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89000">
        <property type="entry name" value="post-HMGL domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13 19 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14 19" id="KW-0092">Biotin</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="9 19" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11 19 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16 29" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="27">
        <location>
            <begin position="44"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="26">
        <location>
            <begin position="166"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="28">
        <location>
            <begin position="582"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="25">
        <location>
            <begin position="1119"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="active site" evidence="20">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="591"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="663"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="22">
        <location>
            <position position="759"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="789"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="791"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="924"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="23">
        <location>
            <position position="759"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-biotinyllysine" evidence="23">
        <location>
            <position position="1160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00072910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRNR" id="PIRNR001594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="EMF10013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1196" mass="131494" checksum="941E92B6DFE5A4D8" modified="2013-05-01" version="1">MSDSIQNESAIDDGDYGTQDPHGETHQDKNTVHQRLRANSSIMQQNKILVANRGEIPIRIFRTAHELSLQTVAVYSHEDRLSMHRQKADEAYVIGKRGEYTPVGAYLAGDAIIKIAKEHGVNMIHPGYGFLSENYEFAKAVEAAGIIWIGPKPKTINDLGDKVSARTLALKAEVPTVPGTPGPVEKFEDAKSFTDEYGFPIIIKAAFGGGGRGMRVVWKQEELKDSFERATSEAKSAFGNGTVFIERFLYRPKHIEVQLLGDNYGNVVHLYERDCSVQRRHQKVVELAPAKDLPQETRDAILSDAVRLAKSANYRNAGTAEFLVDQQNRHYFIEINPRIQVEHTITEEITGIDIVAAQIQIAAGASLEQLGLTQDRISTRGFAIQCRITTEDPSQGFSPDTGKIEVYRSAGGNGVRLDGGNGFSGAVITPYYDSMLVKCTCLGSTYEIARRKVLRALVEFRIRGLKTNIPFLASLLTHPTFIESQCWTTFIDDTPELFNLIGSQNRAQKLLSYLGELIVNGPQVIGQIGESKFKGDAIIPTLAGEDGKPLDLSEPCQKGWRSIITEQGPEAFAKAVRANKGCLIMDTTWRDAHQSLLATRMRTIDLLNIAKETSYALSNAWALECWGGATFDVSMRFLYEDPWDRLRKMRKAVPNIPFQMLLRGANGVAYSSLPDNAIYHFCEQAKKNGMDIFRVFDALNDMDQLEVGIKAVLKAGGVAEGTVCYSGDFLNPSKKYNLEYYMGCVERIVGMGAHILGIKDMAGVLKPKAATLLISSIRKKYPDLPIHVHTHDSAGTGVASMVACAQAGADAVDAATDSMSGTTSQPSIGALVASLEGSDFESGLNPTHLRAIDSYWAQVRMLYSPFEAGLTGPDPEVYEHEIPGGQLTNLIFQAAQQGLGTKWAQTKKAYEQANDILGDIVKVTPTSKVVGDLAQFMVANSLSYDDVHEKADDLDFPSSVLEFFEGLMGQPYGGFPEPLRTKALRGRRKMDKRPGLYLDPINFDKVRETLKEKYGGCSETDVASYVMYSKVFEDYRKWVSSFGDLSVLPTKYFLNKPEIGEEFHVELEKGKVLILKLLAVGPLSDQTGQREVFFEVNGEMRQVTVQDKHAAVENTSRVKADSGDSSQVGAPMSGMVVEIRVKDGSDIKKGDPVAILSAMKMEMVISSPHSGKVEALSVKEGDSVDSQDLICKIAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M3D0T6</accession>
    <name>M3D0T6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HypA-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_135463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758219.1">
        <property type="nucleotide sequence ID" value="XM_016902715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D0T6"/>
    <dbReference type="STRING" id="692275.M3D0T6"/>
    <dbReference type="GeneID" id="27899852"/>
    <dbReference type="eggNOG" id="ENOG502QRNN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019145_2_1_1"/>
    <dbReference type="OMA" id="KFDFFYI"/>
    <dbReference type="OrthoDB" id="10004862at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025337">
        <property type="entry name" value="Questin_oxidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14027">
        <property type="entry name" value="Questin_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF10098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="467" mass="53332" checksum="733CC6EBE282AA89" modified="2013-05-01" version="1">MATASIVQLQAVDKPQFYRPPISQSSTDKATELLQDNHERHHIFFNADGFHNHIAHQLLTIWSLGATPEELQRGYDTNKSYQRPARKPESTIVQGLQDPATFMSHLGVEQHYNDFLEFFRQEIDKKGWQHVLKQYVFAGDERAETMLVRMFAGLLHPIIHLGFGLEFQQPAIIAEALAQAACHDDWIGEVLLPAEAAAEKNGNNDKTIVELIHEIHNHKEIREAPRWSDSNKIRDGLLARAAQPLIDIISQIHIPPEAEAEAEEKEKEILTRQTAEMTHAAILLTAGAQRAHKAIKFDFFLMHSVNATIFWPILNRQAWLSPTQKIRLLEWKIRFDLVLYASRKSPEIRRDEIRGYAPKVVQKQNQNQKQKQQEDHQEAGWDDILERACRVDDDGHAAKLVRAVANGEQVCRPFEGQKGSELAGEDWLKLGYMVIDSVEMEVGERWVRNAGFEEAWENVPERGVGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M3D1P0</accession>
    <name>M3D1P0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Riboflavin synthase</fullName>
            <ecNumber evidence="4">2.5.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_150358</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the dismutation of two molecules of 6,7-dimethyl-8-ribityllumazine, resulting in the formation of riboflavin and 5-amino-6-(D-ribitylamino)uracil.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.9" evidence="4"/>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759539.1">
        <property type="nucleotide sequence ID" value="XM_016906116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D1P0"/>
    <dbReference type="STRING" id="692275.M3D1P0"/>
    <dbReference type="GeneID" id="27903253"/>
    <dbReference type="eggNOG" id="KOG3310">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034388_1_1_1"/>
    <dbReference type="OMA" id="IGGHAMS"/>
    <dbReference type="OrthoDB" id="10258924at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004746">
        <property type="term" value="F:riboflavin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00402">
        <property type="entry name" value="Riboflavin_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000004">
        <property type="entry name" value="Riboflavin synthase, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000006">
        <property type="entry name" value="Riboflavin synthase, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001783">
        <property type="entry name" value="Lumazine-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026017">
        <property type="entry name" value="Lumazine-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006767">
        <property type="entry name" value="PRK09289.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00187">
        <property type="entry name" value="ribE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21098:SF0">
        <property type="entry name" value="RIBOFLAVIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21098">
        <property type="entry name" value="RIBOFLAVIN SYNTHASE ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00677">
        <property type="entry name" value="Lum_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000498">
        <property type="entry name" value="Riboflavin_syn_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51177">
        <property type="entry name" value="LUMAZINE_BIND"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lumazine-binding" evidence="10">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="Lumazine-binding" evidence="9">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="Lumazine-binding" evidence="9">
        <location>
            <begin position="104"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="10">
        <location>
            <begin position="104"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF11418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="230" mass="24596" checksum="8D4E52937F7B6BBA" modified="2013-05-01" version="1">MFTGIVETVGTVSKLVELDESSSGGGGTSLTISDCAEILVDCHLGDSISVNGTCLTVTEFSKNEFKVGCAPETLRRTNLGKLKEGSGVNLERAVSASTRMGGHFVQGHVDTVAVIAEKRPDGNAITFRLQPRDKSVLRYIVEKGYVTLDGASLTVTAVNDEEGWWEIMMIAYTQEKVVMAAKEKGEDVNVEVDMVGKYVEKSVAAYFEGSGATGGAMLEKMVQNIVKGTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M3D2B7</accession>
    <name>M3D2B7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Radical SAM enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_163538</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760501.1">
        <property type="nucleotide sequence ID" value="XM_016908063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D2B7"/>
    <dbReference type="STRING" id="692275.M3D2B7"/>
    <dbReference type="GeneID" id="27905200"/>
    <dbReference type="eggNOG" id="ENOG502QQMH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049058_1_0_1"/>
    <dbReference type="OMA" id="ERWFKKY"/>
    <dbReference type="OrthoDB" id="549750at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051196">
        <property type="entry name" value="RSAD2/Viperin_antiviral"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038283">
        <property type="entry name" value="viperin_w_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21339">
        <property type="entry name" value="RADICAL S-ADENOSYL METHIONINE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21339:SF0">
        <property type="entry name" value="S-ADENOSYLMETHIONINE-DEPENDENT NUCLEOTIDE DEHYDRATASE RSAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01088">
        <property type="entry name" value="antiviral_proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01067">
        <property type="entry name" value="SPASM/twitch_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00318">
        <property type="entry name" value="Viperin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032168" evidence="8">
        <location>
            <begin position="25"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="9">
        <location>
            <begin position="23"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF12380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="319" mass="36364" checksum="DE8D551F7FBD7DFC" modified="2013-05-01" version="1">MFIYSLPALTIVAVLLTCKNPANDIPISVNYHFTRQCNMSCGFCFHTATTSHMVSLEDALKGIRLLKDAGMRKINFAGGEPFLYPKILGKMVDFCKEIGIESVSIVSNGSKITSAFLQQHGKNIDILAISCDSFHEATNLLIGRGTGHNVTQLHRIKSWCDVSGIKFKLNTVICKLNWQENMNEHISRLQPARWKCFQVLIVAGENDSEERLRDGRKYMISKEQFESFIEKHGRQESLIPEPNHLMAKSYLILDEYMRFLDRTGRQPSKSILEVGVRPALESVFWDVESFHERGGLYDWQAHQKGSSCVDEEKSKELEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M3D3I1</accession>
    <name>M3D3I1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF1772-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_45218</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the anthrone oxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760575.1">
        <property type="nucleotide sequence ID" value="XM_016908957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D3I1"/>
    <dbReference type="GeneID" id="27906094"/>
    <dbReference type="eggNOG" id="ENOG502SBMN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105974_2_2_1"/>
    <dbReference type="OMA" id="AFMMGTN"/>
    <dbReference type="OrthoDB" id="5954308at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013901">
        <property type="entry name" value="Anthrone_oxy"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35042">
        <property type="entry name" value="ANTHRONE OXYGENASE ENCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35042:SF1">
        <property type="entry name" value="DUF1772-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08592">
        <property type="entry name" value="Anthrone_oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF12454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="168" mass="17320" checksum="8EEA692B41F5C641" modified="2013-05-01" version="1">MSFAQKLVPAAALIGLSSASFLTAYIYSFSVLTIPVVETGATKDSATFTAKQWSKAFNLGKSFAPPFAITCAACFGFLAFQSRYPISPSVLYATAAVIAPSIVPYTIAVMGPTTLTPLEARATGASGAPGDQETLDLIKKWSGQNTVRAGMVGTAAVMSALAILAQVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M3D4B3</accession>
    <name>M3D4B3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription factor IIIC putative zinc-finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_133622</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF13040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761161.1">
        <property type="nucleotide sequence ID" value="XM_016902571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D4B3"/>
    <dbReference type="STRING" id="692275.M3D4B3"/>
    <dbReference type="GeneID" id="27899708"/>
    <dbReference type="eggNOG" id="ENOG502S8BZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011098_0_0_1"/>
    <dbReference type="OMA" id="RIRAFAW"/>
    <dbReference type="OrthoDB" id="6021743at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044230">
        <property type="entry name" value="GTF3C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024761">
        <property type="entry name" value="TFIIIC_delta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024764">
        <property type="entry name" value="TFIIIC_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15496:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15496">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 4 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12657">
        <property type="entry name" value="TFIIIC_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12660">
        <property type="entry name" value="zf-TFIIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor IIIC 90kDa subunit N-terminal" evidence="1">
        <location>
            <begin position="19"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor IIIC putative zinc-finger" evidence="2">
        <location>
            <begin position="668"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF13040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="780" mass="86275" checksum="B9BFA97C2BD9D83C" modified="2013-05-01" version="1">MACTLTVPFWPTSYDNLHWSKDNQIAVLGGEHILILTPRLHEPNPSHLWWDTENLIRINAFTEPELLRSAVLTDRNTSIGEESSIFHAHAAAWSSPGLARHGGSALAVLTTNHVLSLWAPEPLAKGVAVWQRTLVINHAIRQFYHEKHGMQSDGDGRESEEALQIQQRVRSFAWTQPVHSDLERPHPDLFSGLHHLVVATEGGHILVLRITSPYCDPTNKHSTWQAIISESLYITGLTQSLYLEDTNGLRHPQSTIAMPRPSGVDYVGPEHIAVGEWHSGRSDHKRAAAVVFILEGRLYITSLLHDADGNTSFTSGLKPSVSWHLRDRVDLRGPLKVTPGIDAGALVVFGTNAVFHGQLMFNDIKTSLSVDFNDHHLDDRWDDVTGVTITNSADGNALLHVVSHLSSSTAPTHALQLPLAPGRDAPGQPAWQFALNDSKEAYAATNDLGNHVQERTWGIACAPVNGYTAVCASMHPNDVIAYIINADQASILNITLESEARADDFRLAPAEVDSFSGLPSSTILFFLKRYLEQKVDRETAPQDEHDTLVRHVQNMLSPGHGVGFKSLVRASDSNAILLYKTRISLFANAAVRRVQATRICNLAGSDHALQPEGMTTMIRHVAEVVFSISRDDVEFDDMSMNIRRVYEIAVSKLDANYRPGDREASATAWREQCKICHQSIIFESFKWARCQQGHQFSRCALSLLANQEPATTKECSVCGLHYLDETVVDGFRTVPQDLHMVGLNGEVNSQEENAVSKMTMAELLFKACHVCLYCGGKFGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M3D4U8</accession>
    <name>M3D4U8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_149429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761010.1">
        <property type="nucleotide sequence ID" value="XM_016905543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D4U8"/>
    <dbReference type="STRING" id="692275.M3D4U8"/>
    <dbReference type="GeneID" id="27902680"/>
    <dbReference type="eggNOG" id="KOG4401">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073383_1_0_1"/>
    <dbReference type="OMA" id="CPITNLI"/>
    <dbReference type="OrthoDB" id="1057137at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047574">
        <property type="entry name" value="AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039683">
        <property type="entry name" value="Lsm12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019181">
        <property type="entry name" value="LSM12_ABD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13542">
        <property type="entry name" value="LSM12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09793">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00995">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52001">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AD" evidence="1">
        <location>
            <begin position="107"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS52001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF12889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="217" mass="23435" checksum="922C4A7660A094E0" modified="2013-05-01" version="1">MADAAKRNAGRAATPKATDDVLETAVKAIGGQVRLTNALGAEIKGTLYNADPVSKVVIINSRSPPPNPSTNPSSVPGDYHIVPISAIQSFSVQAGGNSDYMKQTAPTRIDRNFLEKRLETRIEQVKAERQHIGQGVSEDGQRLYDALRKLNTPVRWHGNAAKGTHMIISEAVILDAPFESANCRAAADKQDILQRTKRMVDDQRKKLGLSGGVRKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M3D5Z3</accession>
    <name>M3D5Z3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calmodulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_64090</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calmodulin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761415.1">
        <property type="nucleotide sequence ID" value="XM_016909668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D5Z3"/>
    <dbReference type="SMR" id="M3D5Z3"/>
    <dbReference type="STRING" id="692275.M3D5Z3"/>
    <dbReference type="GeneID" id="27906805"/>
    <dbReference type="eggNOG" id="KOG0027">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061288_2_0_1"/>
    <dbReference type="OMA" id="ARKMKEC"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000058">
        <property type="entry name" value="Calmodulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000257">
        <property type="entry name" value="Calmodulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000027">
        <property type="entry name" value="Calmodulin (CaM)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM01184">
        <property type="entry name" value="efhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="8"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="44"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="81"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="117"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF13294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="149" mass="16997" checksum="391C14BA2C533A89" modified="2013-05-01" version="1">MADSLTEEQVSEFKEAFSLFDKDGDGQITTKELGTVMRSLGQNPSESELQDMINEVDADNNGTIDFPEFLTMMARKMKDTDSEEEIREAFKVFDRDNNGFISAAELRHVMTSIGEKLTDDEVDEMIREADQDGDGRIDYNEFVQLMMQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M3D631</accession>
    <name>M3D631_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_148865</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761751.1">
        <property type="nucleotide sequence ID" value="XM_016905191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D631"/>
    <dbReference type="STRING" id="692275.M3D631"/>
    <dbReference type="GeneID" id="27902328"/>
    <dbReference type="eggNOG" id="KOG0201">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007561_1_0_1"/>
    <dbReference type="OMA" id="FKLWEAQ"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="47"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="367"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="444"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="535"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="696"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
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            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="803"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="919"/>
            <end position="969"/>
        </location>
    </feature>
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        <location>
            <begin position="373"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="444"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="478"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="698"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="803"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
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        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF13630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="969" mass="108162" checksum="54A73FCA027AE8D8" modified="2013-05-01" version="1">MDDSRLNPVGRSIADQRDRDRRIKDAQDLAQTIARNAERTGAALPPYEFLELIGKGAFGKVYKCLDRQTKNLVAVKIIDIDEQDWSEDFSLGDARDATINDFKKEVSILRQLKDNNAKNINLIHDAFDWHSQLWIVADYCTGGSVRTLMRPFEKNGRPIGLPEQYIVPIARELAIAMKSMHDLNTLHRDIKCANVYITEDGDIQLGDFGIVGVIDHDHEKRKTVVGTPHWMPREIVERLGDKETKEGYGYEVDVWSFGCTVYEMATGSPPYATKGIQFLTELLEESPPRLEGNEYSAELRDFVAFCLNPDKKARPSASAILNHPYIKDTSRIYPTRTLVRLIERFKIWEHGGGSRLSLWQASPADSRNLRLGDDDEVENDEEEQDDWNFSTSEDFDQELGRRLSQLPPGAVLEGWNFDSPATSSLPPLQPQPLQTKALTVAERIKQEHSEKSASRGEKSLNKVFDPNDPTGYQLATPIEPPQPPEPEAPSDLPLRAYESSSTSRESVVVMLDLDDAITPATSSLAMRMAAINEDTIRPTGRHAHDDDDDDDDDGYQYGRLSVSDKRDTRAWTFDSAQPRTQRDTRDWTFETALPLQPPLPTLSRQPERETISWSFETAGLAAPELLDDSYDVASGGNDACLAPTRPQLQHTATEPIRHFRGLSSSSVPNRESVTSLIDLDAGLAERVRAGNEILRPGTASSHMTDATSGNPFDLEDDPEQKELDRNRFSYHKPYASEGGMVKRLSHKTMPMHARGTSLSSTEPDLDPGRPAVGGYSAPPSAMSQPDLSFSTLEQGLGLATVETDNNQWPSFSDNDSFTDMPQYLPASADDTHMPRLGQGFSTEHRLHASGTSVSSRSREPSNEPPGPEVDFPSLQPPHPDVLAESADDQILEAELGRMLSDCDYALSSMSRVLHQHASIEADDDEISSDFDSSFESRHQDTEDEDIDHLTARRKPRKLEMRSSPRLPTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M3D8Q8</accession>
    <name>M3D8Q8_SPHMS</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_148046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502S2KS">
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    <dbReference type="OrthoDB" id="61370at2759"/>
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    </dbReference>
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        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF14279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="191" mass="21162" checksum="6FE0B9E681FEAE78" modified="2013-05-01" version="1">MTRRIVYGISLWVFLGSVGCTIASIALPNWISYYSPVEGSEPIRITLGLHKRCSSITGRCSPFPQYDDCRGDDRSFCSIWRSTGFFMNFSVVLLLACVVAYITILVGGRGTREVGWRLLCPLLAVVALTQLIAMSLVAGVYEHDARFFVGWVLDKSFILCTVSWVALLINAASVLGASFCLVPEDDYEEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M3D904</accession>
    <name>M3D904_SPHMS</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_115651</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762495.1">
        <property type="nucleotide sequence ID" value="XM_016901185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D904"/>
    <dbReference type="GeneID" id="27898322"/>
    <dbReference type="HOGENOM" id="CLU_783397_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF14374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="354" mass="39343" checksum="6D1F57854E1444BB" modified="2013-05-01" version="1">MRSGSPFPPQQATVQPKTWNKALKAKIMQAARRKPRYLFSSAILNDDMEHSAMLTRDGIVPQLFRHGFYGYSMSKAANEPPPSSIFSMPLAEVRYHNTTNFLARGPHSERSAMWSLWFSSLREAAEEAVLREAMSTQYAPVAHEVYILVMDTHNLSDDNLVLHESDKYLLEDWNSVSEIRDSFLTFGVIPAEAFEMVPLSVLREHTSYTGALSSASLAPIDVLNKHDAPRDLAHAIHLAHMFGQAFGPKLALPVACIAITASAGTHTNDAGSLGKGSTHEAEIAAAFDYYDIPESILKDRSIVKEKPSIHVSRDTRRGLSLLRIIVKRKQGILESKARSMLQDQSTDAKATDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M3D917</accession>
    <name>M3D917_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MOSC-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_148108</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762510.1">
        <property type="nucleotide sequence ID" value="XM_016904708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D917"/>
    <dbReference type="STRING" id="692275.M3D917"/>
    <dbReference type="GeneID" id="27901845"/>
    <dbReference type="eggNOG" id="KOG2362">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028286_1_1_1"/>
    <dbReference type="OMA" id="ARQYPQM"/>
    <dbReference type="OrthoDB" id="17255at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOCOS_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237:SF19">
        <property type="entry name" value="MITOCHONDRIAL AMIDOXIME REDUCING COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SULFURASE MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141673">
        <property type="entry name" value="MOSC N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="MOSC" evidence="2">
        <location>
            <begin position="228"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF14389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="411" mass="46229" checksum="479B3286F97FEC53" modified="2013-05-01" version="1">MGLTGIINGILGMPKAAVNMYNHPKFWNTQDLDWGYSGYLLAACVVGLITVVLYGSSIGSDVTKRTDNFGIATSSEEKSDSSRPPIPPPTEITSLRIYPIKSCRGIEVDSTRLKKAGLTLDRNWMFIDMSTKKFLTIRSDPRMTLIDTSISEGEGEHKGQQMLDISIHNTEGRVSIPAFPSQSWLSTNTTLETVNIWDKDTDGYLYGDEINSIFCKFFDKDVSLVYKGPTYRMVAINGTKELYGKDTPHHFADVMSLQIASEASIKDLNKRLGHQPHSPDALTIERFRPNIIIRGRDDHPWEEDTWKRVRISTSIPSEEALYRLDLDVVARCARCQVPNVNPDTAEKHAKQPWDTLMNFRRVDDGGVAKYKPCFGMMCIPKNEGKVAVGGRLEVLETTDKHLYAQRAFKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M3DAE0</accession>
    <name>M3DAE0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_132410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762955.1">
        <property type="nucleotide sequence ID" value="XM_016902493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DAE0"/>
    <dbReference type="STRING" id="692275.M3DAE0"/>
    <dbReference type="GeneID" id="27899630"/>
    <dbReference type="eggNOG" id="ENOG502S5CN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061230_2_1_1"/>
    <dbReference type="OMA" id="HHFEGYF"/>
    <dbReference type="OrthoDB" id="3928002at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38049">
        <property type="entry name" value="RICIN B LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38049:SF2">
        <property type="entry name" value="RICIN B LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032426" evidence="1">
        <location>
            <begin position="22"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF14834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="242" mass="27978" checksum="1823ECAF59A93253" modified="2013-05-01" version="1">MVLGILTAIAACPAIIGTTEAVRHGQRQNSREEQRGRKTNLTVSLLHRSEYTSQFDGAYIVLKDHKLWIDTTGLANHLHPFSGYFLPYPHDDVAQSWRKAGFRKAEGMVTTISNDPPFLNWVYVDCDSHEVKFGKRDEVEGHRLGPFDVTKTDRRLTFEGWEGFVAVQEHDGEDLWALYFDVHDDGLTSGERVGTQALRMLALEVWRRELRVDREMAMEERLERIRMRREEEERKSESTTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M3DAZ2</accession>
    <name>M3DAZ2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ams2/SPT21 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_147006</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763135.1">
        <property type="nucleotide sequence ID" value="XM_016904025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DAZ2"/>
    <dbReference type="GeneID" id="27901162"/>
    <dbReference type="eggNOG" id="ENOG502QUGJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001743_0_0_1"/>
    <dbReference type="OMA" id="VMQSEYL"/>
    <dbReference type="OrthoDB" id="3199820at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000183">
        <property type="term" value="P:rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057725">
        <property type="entry name" value="Ams2-SPT21_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042403">
        <property type="entry name" value="Spt21/Ams2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39147">
        <property type="entry name" value="PROTEIN SPT21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39147:SF1">
        <property type="entry name" value="PROTEIN SPT21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25823">
        <property type="entry name" value="Ams2-SPT21_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ams2/SPT21 N-terminal" evidence="2">
        <location>
            <begin position="10"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="523"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="764"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="806"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="992"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1047"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="258"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="301"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="398"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="840"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="896"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="912"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1017"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1061"/>
            <end position="1072"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF15014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1153" mass="125063" checksum="069C1C04DDAFDC24" modified="2013-05-01" version="1">MASTGDFADIPTRPMRVKILYTFDSESKTTCLARLPSTLNIPAVAIDEQSQVGVIDLQQCIDAMVSASPEIMSQLENGDFSVYSYDYSEYDAPVVGQGRMSSLLGNSMPVVEDSKTMITGRVCKNIAIFNNGVKETLEVKFKLTPLARPSRAPNNIDTFRSASPATSAGFDPNAWNTSMQSKPQQQSNEYFDFGMASMGEGSDTASLEELFGMATEGSGEATAQQQRASVGVSQTPTDSAFASYNPAFLTHSHSAPGSRAGSPMVVSSSSSRSELLRHQSFSGNAPSLTDQTRPDSRGSVRSESFSSHMQQQPLQAFEQQTAQQETESFYNEDGQSRKRAKVVQADWRGKSSFGSKSADLRVTAAKSSSMQMFRPVAKRPTAPGTNLEPPPRAPTPVPQRTRPVQPRLQSAVGRSSLRQASVADSDAMSDVDLMSDVMTSPEGSSPGNSMNGDGTPMDIPSSPPIVPGYNHPQPSSPGLPTMASHMADSGYMSGGFRSGTIMESMEDDADRSPDAEYVQMARRYQSSKGPQSTLVKSEGSPIEATPAPYSDMHFSSDVPDVEAGTRGRSHGQSQYRQQAPRAMSAMSPPDDQVSQSRRGSLALPTKAPVKQPRRLLARTNTANESESGSPAPQDAEARSKGPRSGSSAPRRQIIEQRLQESISKGVMPQFCSHCGSIETPTWRKLYVKTVDGKPGPLDSVAGEGETVAVKVTEHNEDGEPTRFQILKTMKKTKDMVIGKGFEYNVLCNPCGLWFNKYCNMRPPEKWARKSGKKATKKRGDYATDEPASEAFYSEQIMPEETNRAAAPLPHAPAPIPQAEVDKSAPTQTGRRRRASSLETQPRRAASDDGNVRRPHRDPEYMRAIQSSPVRSHGSEASPIEVDLTPNPTRRLIFPSPRRDGEEKSLDNHGISRTESAPLSMTAQTEKPTAEVIALAGGNDVNVFEAFAYDKENMAPPFDEDGDLSHLFEGSPGAVFKTPARKTPAKRNITPLSQKQIGPDVLLKTPSQNSRKRKPLTPSANAANNADMNGVNDFMTSPSSTRYFLRSTPSRVERTPGGRTVSGGSNNGSTEVSPFSRHLAQMLNDTDNMGQNAQFTSPTSRQFDFSDLPTFNTPGREIDWKGLDDIMSSDFASYDNGSMAFSTDLPGGQQQQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M3DBF0</accession>
    <name>M3DBF0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Spermatogenesis-associated protein 20-like TRX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_147282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SO2202</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2012-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genome evolution in poplar pathogens from wild and recently domesticated pathosystems.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Dhillon B."/>
                <person name="Feau N."/>
                <person name="Sakalidis M.L."/>
                <person name="Gill N."/>
                <person name="Aerts A."/>
                <person name="Ohm R."/>
                <person name="LaButti K."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Copeland A."/>
                <person name="Beauseigle S."/>
                <person name="Grigoriev I.V."/>
                <person name="Goodwin S.B."/>
                <person name="Tanguay P."/>
                <person name="Hamelin R.C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763501.1">
        <property type="nucleotide sequence ID" value="XM_016904198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DBF0"/>
    <dbReference type="STRING" id="692275.M3DBF0"/>
    <dbReference type="GeneID" id="27901335"/>
    <dbReference type="eggNOG" id="KOG2244">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014051_1_1_1"/>
    <dbReference type="OMA" id="PFYFGTY"/>
    <dbReference type="OrthoDB" id="1923667at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02955">
        <property type="entry name" value="SSP411"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024705">
        <property type="entry name" value="Ssp411"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004879">
        <property type="entry name" value="Ssp411-like_TRX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899:SF1">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03190">
        <property type="entry name" value="Thioredox_DsbH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006402">
        <property type="entry name" value="UCP006402_thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spermatogenesis-associated protein 20-like TRX" evidence="1">
        <location>
            <begin position="76"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF15380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="800" mass="89980" checksum="6B91D370207C48D5" modified="2013-05-01" version="1">MPGITRPLTSLTPRRLLSAQAAVTPRSVLPPLPYLQQSRLSRCERAEFNGNRLLTAITRRTATTMSDAINRLPLRNRCAESKSPYVRSHIDNPTAWQLWTPETLELAKETNRLLFVSIGYSACHWCHVMAHESFDDPRIAQLLNENFIPVKIDREERPDIDRQYMDFLQATNGGGGWPLNVFVTPGGLEPIFGGTYWPKRERAQQARTGFEDIILKVSTAWREQEQRCRQSAKDITRQLREFAQEGSIGGKDVNRTDDDAELELDLLDDAFQHYKMRYDDKHGGFGGAPKFPTPVHIRPLLRVASYPATVREIVGEEECIEARSMALMTLEKMAKGGIKDQIGHGFARYSVTRDWSLPHFEKMLYDNAQLLAVYLDAYLLTKSPLFLEIVKDIATYLTSAPMQSELGGIHSAEDADSFPTINDKHKREGAYYVWTLEEFEQVLSEEEVKVCAKYWNVKAEGNVDRRHDAQGELIKQNTLCVSRETAELAEELNMAEDDVKRAIDSGRQALLAYREANRPSPSLDDKIVTSWNGLAIGSLARAGAALREVSPEAGSSYVSAARKAALCIQNHLFDAMSGTLRRVYREGPGETQGFADDYAFFISGLLDLYEATFDSDFLQLADTLQETQNKLFWDPEKYGFFSTPAHQPDILIRTKDAMDNAEPSVNGVSASNLFRLGSLLNDEEYSKMARRTVACFEVEIEQHPGLFSGILSSVVASRLGMRGVMVVGDGEAAQAVLKNARETVRSNYTILRIGSGANSQWLKSRNELVKDLDETRDMVQLCEGQTCRLLTLEQIQQELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M3DCV2</accession>
    <name>M3DCV2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_123886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763765.1">
        <property type="nucleotide sequence ID" value="XM_016901868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DCV2"/>
    <dbReference type="STRING" id="692275.M3DCV2"/>
    <dbReference type="GeneID" id="27899005"/>
    <dbReference type="eggNOG" id="ENOG502QT51">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028757_0_0_1"/>
    <dbReference type="OMA" id="HMIIELV"/>
    <dbReference type="OrthoDB" id="4155914at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="541"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="242"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF15644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="640" mass="70100" checksum="F317EE5C6151777F" modified="2013-05-01" version="1">MNTHAGGAPGKTSSDSGTNAVALDRWSQRRLQRLNTEQGFREQRQGGPTVLSPPATAAPVEQQSYIQSSGGPSQHTNVNAQPQQPLHHQPHPQQQQAAYQNSRTAPGLVIQTQTSTIPPLRSPAFQSQAQAHQQLQQQQQQQQEYTPPESHSHYVADNADRPALNSARSFSAQTDDSSSMSNNGAMAQPKAVRNGNNRQSVHNDLRSREGSHSTQGSQMPAFSAAVVPPSSQGQPYKGNGGQTQQQPPQAHQQQQQHGEVGRATPQPLSVPDEMNDDEVSQLLKDHKELREKYTKVKKYYFEKEDQVKQLQNSLAHQRLAQSRTSLDDSEYTTRFNRLDGLVAQLAFSIRKNWKSIPHWLVGSVNRDAVVTGKQEMTAAGRAFISNWLVDEVFHKYFHPDLEPALSAQLRNIQTNIRRHAPLAQSAEEEEYLTSKVVNWRLATLDGLAETLRSPQCPENRQRLTDSLKDGLVSSLSMHLQDPPPSDLEGGVHMIIELVVSIAIHLPLESRDVAIEYFQPGHGIMGDQMKTESGIPPLVTSVADDQTERASMKSAASDVTDMTDSNADQGSGRGGKRSMLSAITGKPKPSKHAGVSSGSLGRPESAQGMKEDQPPRVRMAAGIGVSVRGRSILVKAPVFTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M3DDC0</accession>
    <name>M3DDC0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Coenzyme Q-binding protein COQ10 START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_61098</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763945.1">
        <property type="nucleotide sequence ID" value="XM_016909549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DDC0"/>
    <dbReference type="GeneID" id="27906686"/>
    <dbReference type="eggNOG" id="ENOG502S6PP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069867_0_2_1"/>
    <dbReference type="OMA" id="VYVVRWM"/>
    <dbReference type="OrthoDB" id="509124at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07822">
        <property type="entry name" value="SRPBCC_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF15824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="24280" checksum="276B3318138DD75A" modified="2013-05-01" version="1">MTSASSWPPSSGLTTVVVPRTDAVFHISSSTTIAAPASLVFDIVLHTDEYKEWNQFVPSARIAKQEAADGRDANHPSHMHSNCIMTFDVVMNSKKPAGITETNLLVTDISTPEQPTGYVSEELLQDPSFTADQSKVYRVSWATHGGFVARGLRSERFHEVIATSDMECEVRTWEVMGGVLAYTVKWLYHSTLQDKFALWTSDLKKRAESKYAEQHPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M3DF33</accession>
    <name>M3DF33_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_106289</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF16134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764255.1">
        <property type="nucleotide sequence ID" value="XM_016900626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DF33"/>
    <dbReference type="GeneID" id="27897763"/>
    <dbReference type="HOGENOM" id="CLU_1469090_0_0_1"/>
    <dbReference type="OrthoDB" id="10477391at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF16134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="184" mass="20029" checksum="FF0AC96540FBD262" modified="2013-05-01" version="1">MADPELATSHTKRISYAEYDYMYPSTSDPVTNPNNNNSTTTTTTPTVLNFHIRRSEIKEFTIIPLDNLSTARSIIASKLDSLSTSPTRVVLLNDEARVDMPEVSLDELEKLVREETVLGSGRARQLFVIVYDCDPTISSTGGGGHGGERVGVGNSSSGCCEGGGKIPYQGRRREVRLKDCCAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDC2</accession>
    <name>N1QDC2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endo-1,5-alpha-L-arabinanase A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_151392</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycan metabolism; L-arabinan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757442.1">
        <property type="nucleotide sequence ID" value="XM_016906787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QDC2"/>
    <dbReference type="STRING" id="692275.N1QDC2"/>
    <dbReference type="GeneID" id="27903924"/>
    <dbReference type="eggNOG" id="ENOG502SM7B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010779_0_0_1"/>
    <dbReference type="OMA" id="LYNTADH"/>
    <dbReference type="OrthoDB" id="19657at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08983">
        <property type="entry name" value="GH43_Bt3655-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050727">
        <property type="entry name" value="GH43_arabinanases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301">
        <property type="entry name" value="ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301:SF3">
        <property type="entry name" value="ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109742" description="Endo-1,5-alpha-L-arabinanase A" evidence="7">
        <location>
            <begin position="20"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF09321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="347" mass="38080" checksum="12A759159819B495" modified="2013-06-26" version="1" fragment="single">MRPFVFHLLTAALSGLVHATPTTLESRQAGQYAGYAFAYFTGNTIDGEKIYFAASNGNNALDWQELNGGKPVLSSTQGTKGLRDPFVIRSVDGGKFFLLATDLSIGSGTSWGESVRTGSRYLEIWESSDLVNWGQQRHVLVSPPTAGNTWAPEAYYDEDISAYVVYWASSLYEESDTAHTGNTYHRMLYATTQDFKTFSEPQIWQDAGTARIDSTVIKSGNTYYRFTKDEGAVSGCTDIIQESSPRLLDQLDGWTTITTCIGKNAGTKAIEGPTSFRANSGDVNGDKFYLFVDEYGGRGYIPLETADIAKPQWKVSASYKLPKSPRHGTVIPVTAAELQRLTSALKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDF6</accession>
    <name>N1QDF6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_151433</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757522.1">
        <property type="nucleotide sequence ID" value="XM_016906820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QDF6"/>
    <dbReference type="STRING" id="692275.N1QDF6"/>
    <dbReference type="GeneID" id="27903957"/>
    <dbReference type="eggNOG" id="ENOG502QVHF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019468_0_0_1"/>
    <dbReference type="OMA" id="DLRWTEP"/>
    <dbReference type="OrthoDB" id="2150628at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051667">
        <property type="entry name" value="Archaeal_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011579">
        <property type="entry name" value="ATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37096:SF1">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37096">
        <property type="entry name" value="YALI0E33429P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01637">
        <property type="entry name" value="ATPase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase" evidence="2">
        <location>
            <begin position="269"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF09401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="542" mass="61645" checksum="ED6AAD31CB025EE0" modified="2013-06-26" version="1">MLPLVVRRQACLGHYHSSHVVVRGHVRALIPQRRTFFGMGEIIGVLTNPAATLQQLKESKDMLEKAREESELKNERTKLPPKHTFSKLPGFHGRQAEQTLLRKILSNTAKMTVMFGATSVGKTALLREVLATDDFYVVKFDLRISGFADLRTLYIALCEQFEQFFAEMHDEEMEKNGLVFKHLKRDLLEKLQPADNNAGYTVTVADLASLMESLQSCLLKYWEYDPRAAGNEGDGDGAEKMAEKMKKIAKDGSKDSGETHEEPPEPFQKRPIVFLMDEAHKLPALVDDQLSLKVFLDTLLVLTKQDRLCHVILATSDSFFHHFLRTMNVGHHCQLVTIGDCSREETKAYFDDIIQDTIPEHLQHKISFEELYDAFGGKLAHISDYVSSWVNCDGDLTIYESAIFVQAYTLLQFHLTRSTFATYSPLSVAISGTSTDKDDSTFTPEHLVHVMKKMVESPYSLPYFQLCKEIGTSEVDSMIKTRILELRWTKSVAPEDTAAEHIWSKDGIQRPVVLPMTRIVRRAMEVVLQEDAEREKIAKEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDT4</accession>
    <name>N1QDT4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ZN622/Rei1/Reh1 zinc finger C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_151651</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757857.1">
        <property type="nucleotide sequence ID" value="XM_016906956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QDT4"/>
    <dbReference type="STRING" id="692275.N1QDT4"/>
    <dbReference type="GeneID" id="27904093"/>
    <dbReference type="eggNOG" id="KOG2785">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018787_2_1_1"/>
    <dbReference type="OMA" id="WNTETPV"/>
    <dbReference type="OrthoDB" id="19329at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041661">
        <property type="entry name" value="ZN622/Rei1/Reh1_Znf-C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040025">
        <property type="entry name" value="Znf622/Rei1/Reh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182:SF8">
        <property type="entry name" value="CYTOPLASMIC 60S SUBUNIT BIOGENESIS FACTOR ZNF622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182">
        <property type="entry name" value="ZINC FINGER PROTEIN 622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12756">
        <property type="entry name" value="zf-C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZN622/Rei1/Reh1 zinc finger C2H2-type" evidence="2">
        <location>
            <begin position="137"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="300"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF09736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="384" mass="41742" checksum="9ABF1CF7C2A351FE" modified="2013-06-26" version="1">MSRSGVFCSACAPVSESAPQRRDHMRDAWHVSHDAQRRVDALPPALFDVDGPKKIAVPTCKHGTLSLPKNLPSKADSADGCGDVVYGSSAATVYSHPITFTAGCDDHSVTASVSGPASVSGPTPEVVTDELHEATHCLFCTHIDHDLEHNLSHMRRAHGFVVPDLNNLATDLESLITYLGLVIDVYHTCLFCGHEKYSREAVRAHMLSKGHCQLDLAEGSEFLDFWASNENQADEKLQRPIPSLSSDTEFQLPSGTIVISKRTTCRPSAKHFPIRAKSPDRTHLGSGTNSSSRTSRDSCSDLTSSSYSSSSRKDQIERVPLAPRDAAGVVGLSSGQRRTLAVAHRRAKTSEDRATNKARWTLEKMGNSVKQKHFRPDVPGPKNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1QE05</accession>
    <name>N1QE05_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nucleoside_tran-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_143154</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758601.1">
        <property type="nucleotide sequence ID" value="XM_016903030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QE05"/>
    <dbReference type="STRING" id="692275.N1QE05"/>
    <dbReference type="GeneID" id="27900167"/>
    <dbReference type="eggNOG" id="KOG1479">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021611_3_0_1"/>
    <dbReference type="OMA" id="GSPWTTK"/>
    <dbReference type="OrthoDB" id="46396at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034257">
        <property type="term" value="F:nicotinamide riboside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002259">
        <property type="entry name" value="Eqnu_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332:SF88">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01733">
        <property type="entry name" value="Nucleoside_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016379">
        <property type="entry name" value="ENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01130">
        <property type="entry name" value="DERENTRNSPRT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="402"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="440"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF10480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="465" mass="50671" checksum="EDD65D000CD8BB16" modified="2013-06-26" version="1">MDRLRKVWQGQHQQPYQPVPSNSGGDGEEEEDEADIVNSTSALQPKPTDHHHHHNGFYVEYSIFLLLGISMLWAWNMFLAAGPYFQHRFRDNDWIFANFQAAEISVSTITNLGAMLILTRLQSGANYAKRIVLGLGINMVVFSLLAVSTAIETSAGVYFAFLMAVIFFTSLATGFCQNGVFAFVSGYGEPKFTQGIMTGQAIAGVLPCIAQIVSVLSVRPKEGESEQGGHGPPPVNWKAALAYFVTATVISVVTLLAFSVLAARDNRPSAKRQLPTHDMADEPAERKSIPLLYLLKKLIWLAAGVFVTFAITMVYPVFTQRIVSVRPPSEQPPILQPASFIPLALLFWNSGDLAGRLITAVPALSLVRWPRVVFIFACSRLAFVGLYHLCNIRGQGAIISSDFFYLVVVQLLFGLSNGYLGSTCMIGAGEWVAEEEREAAGGFMGLCLVGGLTAGSLLSFFITGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>N1QE88</accession>
    <name>N1QE88_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">BAH-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_49440</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758792.1">
        <property type="nucleotide sequence ID" value="XM_016909112.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.N1QE88"/>
    <dbReference type="GeneID" id="27906249"/>
    <dbReference type="eggNOG" id="KOG0955">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001514_0_0_1"/>
    <dbReference type="OMA" id="WVMDEPP"/>
    <dbReference type="OrthoDB" id="336088at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048189">
        <property type="term" value="C:Lid2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036205">
        <property type="term" value="P:histone catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15571">
        <property type="entry name" value="ePHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15497">
        <property type="entry name" value="PHD1_Snt2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.490:FF:000018">
        <property type="entry name" value="Lid2 complex component snt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000949">
        <property type="entry name" value="ELM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029617">
        <property type="entry name" value="Snt2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47672">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SNT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47672:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SNT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00439">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51156">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BAH" evidence="6">
        <location>
            <begin position="169"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="ELM2" evidence="7">
        <location>
            <begin position="470"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="8">
        <location>
            <begin position="1025"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="563"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="760"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="842"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1211"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1289"/>
            <end position="1342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1355"/>
            <end position="1590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="87"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="872"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="891"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1289"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1431"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1510"/>
            <end position="1554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1574"/>
            <end position="1590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF10671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1590" mass="174838" checksum="7184E0893C3E0C96" modified="2013-06-26" version="1">MAIQPEASYGTRSRNRTSTRPNYAEDQEMDFEYSSSAATTGKKKASETSSSATNTLTQASDTKRAPEVTSFQAINGHGGSVAGAGGKDSSASTPTATTTGTSKKRKAAGHAAAALQATTASATPPPVAARKPAAPAGLSSQARETNVMSFSKHRACLNKKGELIADDGTKLSVNDHVYLVCEPPGDPYYVCRIMEFLHVDSDDPTSPVDALRVNWYYRPRDVQRFSSDTRLVYGTMHSDMCPLTSLRGKCAIKHRSEIEDLDAYRKERDSFYFVQVFDRFIRRSYECIPVKQIVNVPDKVKKALDERWRFVVVEIGRVKELTSAAKSCKRCTRYCASSDSVDCAICKMSYHMNCVQPPLPKKPSRGFAWACGPCSRASEREHEARNTPNASGHVTEAEEEDAAQLEDAAGLSNDITRAPSPNVDDMVIDEHPATQAEIALAKMWPMRYLGIHARVEDALQYDDRAIYPRASSRLGPRHQASVNMWHGRPVELIKPAEIKKRYMKAGAQKKDTKFTKETLAAIEADKEEKAKRPKWVQDEPVGYVARGEDYDAKDPRCTATPIFVMPPLDKPPKQADASEPDPVKRNENFVSAYLQRAKPLARNIGVPPFGTNFLDRAMEMLLNSKYNIDAALKALQKTDRVKDLHEPVLSKQDLVKFEEGVAKYGSEHRLIRLHMKTTLPHADIVRFYYLWKKTPKGREIWGNYGGRKKKKAEPAGDAGSKLQAELADDVDDSAFDSGKAVRKNRGFQCKFCHTTHARQWRRAPGVSPGQVAPPEKVDKGQKVDKKDRPLLALCLRCAGLWRKYAIQWEEIDEVTKKVGQNGGKGLKRKIDEELLRELIAANEAAAHPPEPEPLTQPAIDVGEPPKKKSKTSKAAAAAAAAAVAAVEPVEKPAPPPPPPKEPTPPPPPIIPTQPTWKVLPCAVCKGFDHTIACAHCKLTVHRRCFGVGEHEGARPNGEVHWICEQCQNDRNPMVSTDYSCCLCLTEETLIDLVEPPRVSHKKKTDREREKERLEKELADGMRNEYRNRQLAHHRPTLPREPLKRTTGNNWVHVACGLWANEIKYSDAQKLEIAEGFQLIPQARFEAVCKLCKNRDHKSKFRENAGACINCSQCQAAFHASCAFEANYTFGFDVQPVKGSRKDQVITATLGNETGSLNPIVLCKEHTFKGVLHPIDEFYDDIGKNALQVYAEAYKQADLTLTGTARKAAEAQLTKDKKGQQPVASQSANRRESGVHGIAAAVRRGARTSAAAETKIEPEDGAPDLATVPDMESRRCAHCDVDVTPMWHPLLPAPAQAAPKSTEPEKPADAPQPANPTPPPEDGEPRPATSPALPPLITKRPTPATIPSIEEQFRAIDNPPQRQTPVLPPSTPINGMLGHGSNGPYGPPHHVYPQAFHQPNGYHQPPPAASMGGMHMHERQNSYGNYAYHQPRPSPIPPAPHYGPSFAQSHPRPPLNGFAPPGQNPGSGLRSPHLGQPSPNYPPPSQHHQQIPGSQSQHAPQPQHPPPHHPQNPMNAPAHQQQAQQQSQQQQQHQSQPVQPAQQSQQNPATPSQSSVRLEGGDAPRPTTPRGGQVNGITGASASPNLANLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>N1QED6</accession>
    <name>N1QED6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Leukotriene A(4) hydrolase</fullName>
            <shortName evidence="14">LTA-4 hydrolase</shortName>
            <ecNumber evidence="14">3.3.2.10</ecNumber>
            <ecNumber evidence="14">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SEPMUDRAFT_127360</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>an epoxide + H2O = an ethanediol</text>
            <dbReference type="Rhea" id="RHEA:19037"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32955"/>
            <dbReference type="ChEBI" id="CHEBI:140594"/>
            <dbReference type="EC" id="3.3.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13 14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.3.2.10" evidence="14"/>
    <dbReference type="EC" id="3.4.11.-" evidence="14"/>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758841.1">
        <property type="nucleotide sequence ID" value="XM_016902144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QED6"/>
    <dbReference type="STRING" id="692275.N1QED6"/>
    <dbReference type="MEROPS" id="M01.034"/>
    <dbReference type="GeneID" id="27899281"/>
    <dbReference type="eggNOG" id="KOG1047">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014505_1_1_1"/>
    <dbReference type="OMA" id="CTALQWM"/>
    <dbReference type="OrthoDB" id="79562at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000328">
        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061957">
        <property type="term" value="C:NVT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120113">
        <property type="term" value="P:cytoplasm to vacuole targeting by the NVT pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09599">
        <property type="entry name" value="M1_LTA4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000009">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.320:FF:000001">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000004">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2010.30:FF:000001">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.320">
        <property type="entry name" value="Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012777">
        <property type="entry name" value="LTA4H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049980">
        <property type="entry name" value="LTA4H_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038502">
        <property type="entry name" value="M1_LTA-4_hydro/amino_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034015">
        <property type="entry name" value="M1_LTA4H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015211">
        <property type="entry name" value="Peptidase_M1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02411">
        <property type="entry name" value="leuko_A4_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45726">
        <property type="entry name" value="LEUKOTRIENE A-4 HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45726:SF3">
        <property type="entry name" value="LEUKOTRIENE A-4 HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09127">
        <property type="entry name" value="Leuk-A4-hydro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01263">
        <property type="entry name" value="Leuk-A4-hydro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 14 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 14" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal" evidence="15">
        <location>
            <begin position="487"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="406"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="153"/>
            <end position="155"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="288"/>
            <end position="293"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="590"/>
            <end position="592"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR612777-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR612777-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR612777-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMF10720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="635" mass="71634" checksum="029E778AECBA2291" modified="2013-06-26" version="1">MAIKPVSDGIAMEAAKTIHTPRDPNTLSNYNAWRTKHTAADFNVDFEGKRLTGIVHLTLESLASEKQIVLDTSHLEILGVDIEGDQVQWKLNQNRIEPYGSPLTIHLDDKHSKTAGSEITLRIGVNTTKDCTALQWLTPAQTSNKKHPYMFSQCQAIHARSLLPCQDTPDVKSTYTFNIRSPLPVLASGLPTGVRDFVPGKEGKPGTLLYSFHQKIPMPSYLFALASGDLASASIGPRSQVWTGPEELTAAQWEFEADTEKYIQIAEKIVYEYPWTTYNVLVLPPSFPYGGMENPQYTFATPTVVSGDRQNVDVIAHELSHSWSGNLVSNASWEHFWLNEGWTTYLERRIQADYHGGDEHRDFSAIIGWKALSDSIEQFGEDHEFTKLIPDLKGKDPDDAFSSVPYEKGFTFLYTLEKLIGKDKFDKFIPHYFTTFKKRSVDSYEFKATLIEFFASDAEVTKKLNDLDWNTWFYKPGFPPKPDFDTTLADQALALANKWEALSTGSSKDFEPSKSDIASFSALQSVVFLEKVQTFDKPLPTELVELMGNTYGFETSKNVEVVSRYLIVGLQAHAKSVFEPTAKLLGEVGRMKFVRPLYKQLIQNDMALAKKTFAKNQDFYHPICKSMVEKLFEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1QEI8</accession>
    <name>N1QEI8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_165407</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758926.1">
        <property type="nucleotide sequence ID" value="XM_016908170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QEI8"/>
    <dbReference type="STRING" id="692275.N1QEI8"/>
    <dbReference type="GeneID" id="27905307"/>
    <dbReference type="eggNOG" id="KOG4169">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_13_0_1"/>
    <dbReference type="OMA" id="CGFYCIP"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229:SF4">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF10805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="281" mass="30274" checksum="D11873F2C87E0B75" modified="2013-06-26" version="1">MAPTTKTAYVTGGASGIGRAVAEMLARRGIRVAIADSNLAQAEVVARSLTQDALAVGVDAAKWESQVEAFERVLRDLKRVDYVYAIAGIGEKSWIPNDPTQVGFVKPNLAVLDVDLTGVLYTAALAIQQMRRQEPDEDGWRGKIAVTASVCGFYCVPTLPIYTAAKHGVVGFVRSYGKHLPREQITLNAICPDVVRTGISKEDFYSVMEAKGLLVPMELVVQAFEQCLDSSISGETLEIEPKTGIVSRSGPEPLDKETEESMDMLHARGAPLHAIGTKLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1QEN0</accession>
    <name>N1QEN0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_127510</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759052.1">
        <property type="nucleotide sequence ID" value="XM_016902150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QEN0"/>
    <dbReference type="STRING" id="692275.N1QEN0"/>
    <dbReference type="GeneID" id="27899287"/>
    <dbReference type="eggNOG" id="KOG1290">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_81_2_1"/>
    <dbReference type="OMA" id="HRYRQGG"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="38"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF10931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="400" mass="45795" checksum="4E65AA1411DE8393" modified="2013-06-26" version="1">MDWSTHRCDINAEPLHRYQRGGYHPVHLGDCLGHNDRYKILHKLGWGGYSTVWAARDMSNQTYVAIKISVSEPQGQNRESTVLQTIATAHANQPGYQYLMTMTDFFEISGPNGKHECLVLEFLGPSVADYLDAHSLDERLPGVLAKSVVKQALLGLSFLHERGIAHADLHTRNLAFTIPSLQALREEDFLRKLGRPETGTVQRTDGQPLGPGLPRYLVRPTSYHQDIETSFGPIKIVDFGQSFLRNESPDTLHTPFPYRAPEIIFQDKVDYRVDLWSMGCLFFELIVGQTIFDNMVPKPAMLIRQMLETVSDYDTLPDRWKLACQDLLDNEQRPPSDEEDPTYTLHAWLEETYYNSGVEKRTDLSREDISRVGMLIGRMLRLEPLAREEAKEVVRDEWFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1QEN5</accession>
    <name>N1QEN5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tautomerase cis-CaaD-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_110171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759062.1">
        <property type="nucleotide sequence ID" value="XM_016900831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QEN5"/>
    <dbReference type="GeneID" id="27897968"/>
    <dbReference type="eggNOG" id="ENOG502SN9D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113367_0_0_1"/>
    <dbReference type="OMA" id="MPLWLIY"/>
    <dbReference type="OrthoDB" id="2129288at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="entry name" value="Macrophage Migration Inhibitory Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028116">
        <property type="entry name" value="Cis-CaaD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14832">
        <property type="entry name" value="Tautomerase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tautomerase cis-CaaD-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF10941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="163" mass="18814" checksum="A969038C400FBE0D" modified="2013-06-26" version="1">MPHWIIYHPPDTFLDVETKQALSNDITSIYTRPEIGMPAFYVVVTFIPIPDESQFVGGEVARSRRGEGKPFIRLCITHIHIRLPENDEQVYADMTGRVDAVLKPYIADKGYDWEYHIAETERLLWKLNGVYAPEWKSADEKVWVAANQVVRPEEMEGARKRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1QG11</accession>
    <name>N1QG11_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">tRNA(m1A58)-methyltransferase subunit TRM6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_134153</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRM6/GCD10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760389.1">
        <property type="nucleotide sequence ID" value="XM_016902613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QG11"/>
    <dbReference type="STRING" id="692275.N1QG11"/>
    <dbReference type="GeneID" id="27899750"/>
    <dbReference type="eggNOG" id="KOG1416">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010916_2_0_1"/>
    <dbReference type="OMA" id="EGYIFHA"/>
    <dbReference type="OrthoDB" id="10254665at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017423">
        <property type="entry name" value="TRM6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12945">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12945:SF0">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT TRM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04189">
        <property type="entry name" value="Gcd10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF12268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="586" mass="64466" checksum="ABAEC50143A7E4E9" modified="2013-06-26" version="1">MAATYSNIRPNTYLFLRLPSDLLRLVEIKVNTIIEVGKLGSFPSNLLLGRPYHHTYEILEKREGEQYSRLRIVSQAELNAEAGLDEATTAESRAEPAVPNGTSSLPNGYELLGEDGSILLKNNRLTIDDATRQTLSQAEIEELKKSAGAKEVIEKIMASHTGLDEKTVFSKAKYMLRKNKKYLKRFTALPMDIGNLIDYITDKEPPRIMDMREESLGLITAWSHAHYSGIDGLPDQKDDGTSYGRWLVAEDTGGLIVAALAERMGILHASESKDRPKAEKAQIEADATSAAGQALNGEAAEAIKSQPVHRDYPPPATSNTITLVHPAVQPNVSVLKYFGYDTSSTTGNADQAEHPLHTHFKSLSWLQLLQPQEDPLYAEPEQASEEVLASWKSGKRGTYFKKRRRWEHCKSIVDETRLGEFDGLVIASPMDPVSILEHTVPLIRGGGHLVMYSPTIEPLVSVMDLYSKERRGAYIAHLSKNELPDADDFPVDPRLLLAPSIQTSRIRDWQVLPGRTHPLMTSRGGAEGYVLTARKVVPLAGGVDARGNFHGKKRKTFHSDVAAPVAPANDVSDASANGTEAVTIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGD6</accession>
    <name>N1QGD6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_150857</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759023.1">
        <property type="nucleotide sequence ID" value="XM_016906441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGD6"/>
    <dbReference type="STRING" id="692275.N1QGD6"/>
    <dbReference type="GeneID" id="27903578"/>
    <dbReference type="eggNOG" id="KOG0546">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_33_1_1"/>
    <dbReference type="OMA" id="FRYRHTK"/>
    <dbReference type="OrthoDB" id="407558at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000025">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase CYP19-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
        <location>
            <begin position="11"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="172"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="277"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="300"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF10902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="380" mass="43164" checksum="86BC130D0DD7B884" modified="2013-06-26" version="1">MAAATNRPRVFLDISIGEEPAGRLTIELFSDYTPKTCENFRQLCTGEHDELSYAKVPFHRVIDEFMVQGGDIAKGDGTGITSIYGGAFEDEYLDWREMDAAGLVCSANRGRDTNGSQFFITLEPCPHLSGKHTIFGRLVSGEETLERIAKVAVDKNDMPTEPVLVSRCGELEKKQKQKHKHDSVRDIQALESPGDDRGRRRKSDISDDEMDTGTTPPRTGRRSRRQSDSVIDEGLRGRPRARSNSQSASKAIEEEDESSDTSATTLHKRKRSPSPSRHMDRREEHADDTERRRRSLPNQYRDRNGDTDRYRPSPRRDDQRHAGRRDNNRYRPSRDHHPDTGRLDHDGRLGGGGYDSGQPDTPVKFKGRGVMKYRENDRAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGI0</accession>
    <name>N1QGI0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DUF1751-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_145564</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764396.1">
        <property type="nucleotide sequence ID" value="XM_016903135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGI0"/>
    <dbReference type="STRING" id="692275.N1QGI0"/>
    <dbReference type="GeneID" id="27900272"/>
    <dbReference type="eggNOG" id="KOG2890">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043563_1_0_1"/>
    <dbReference type="OMA" id="EIHFWEV"/>
    <dbReference type="OrthoDB" id="73612at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1540.10:FF:000004">
        <property type="entry name" value="Transmembrane protein 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013861">
        <property type="entry name" value="TMEM115/Pdh1/Rbl19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13377">
        <property type="entry name" value="PLACENTAL PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13377:SF3">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08551">
        <property type="entry name" value="DUF1751"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01160">
        <property type="entry name" value="DUF1751"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110308" evidence="7">
        <location>
            <begin position="26"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="290"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="343"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="357"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF16275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="389" mass="41989" checksum="FEF8079DFAF0845A" modified="2013-06-26" version="1">MPRINLPPITRTLLLVLITLSSLNAVLRTTKWRMSLDSNPAATTATDYLSSPRWSVPYLVCVPTQSIRFPWTVLSGALIENNVVSLVISGSVLFFGGRYLERAWGTKEFGKFVLFVTMIPNIITFFIYAVWHGLVVAAPEHPTPLNGLVALEAGFLVSLKQLVPEHTVSIFKGTIRMRIKHFPAVFVLANMISGPLLGTDTAFWLSLLGFLTSWLYLRFFRISDISNATTGGQDTIIKGDASETFSFTAFFPDFLHPILSPICDGVYNLLVQLRVCTPFSDQDIEAGNENAASRAAEGGLPSFNSGGSGGRRAEAERRRAIALKALDQRLNAAAASRSAGAPSVTNVQVTLSADGPDGNGGGGGVDQGVENAEEKNKKNKGLAVEIEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGV5</accession>
    <name>N1QGV5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cyclin_N-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_145697</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764577.1">
        <property type="nucleotide sequence ID" value="XM_016903210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGV5"/>
    <dbReference type="STRING" id="692275.N1QGV5"/>
    <dbReference type="GeneID" id="27900347"/>
    <dbReference type="eggNOG" id="KOG0653">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020695_4_0_1"/>
    <dbReference type="OMA" id="QHMRQME"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044843">
        <property type="term" value="P:cell cycle G1/S phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20537">
        <property type="entry name" value="CYCLIN_CCNO-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20559">
        <property type="entry name" value="CYCLIN_ScCLN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000010">
        <property type="entry name" value="G1/S-specific cyclin Cln1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 5" id="KW-0195">Cyclin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="115"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="8">
        <location>
            <begin position="210"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="214"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="421"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="431"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF16456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="444" mass="50725" checksum="F32AD21768030454" modified="2013-06-26" version="1">MSLVDNMAYQSQTSQPLAAPRTFPAFGYCDSYFVESHDDDNGVYARAALERERARNVAKLRQKALAQELSRLTADEYQEDVLDHMEYMEGETMPDIHSIEIQTEIQWFMRPYLLDFLLEAHHAFQLLPETLHLAVNLLDRYCSRRVVYKRHYQLVGCAALLVAAKYGDRKERVPTIRELKSMCCSLYDDDMFTQMEWHVLQTLNWVVGHPTVTSFLQLALPVAGTFDLELEHMTWYISELALYHKEFIPVRPSVMARSCLALARCILGRLQSTSDDWAARYDAQVVLNLSNHLSHPSQALLRKYASPHLSEVSSTIQRFLEHQARLVSAQRAAQNQTPINETLMDIDSQPMVNSHLMPQTPQKVGYAAHPFGMLTPPITPDKDQMAVVSYGTKPGFVSRAAHCVPTPPSVGEQMHHNSYVVQQQPQPQPQPQQQQYMPQPQFVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGX4</accession>
    <name>N1QGX4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_149626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759840.1">
        <property type="nucleotide sequence ID" value="XM_016905673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGX4"/>
    <dbReference type="STRING" id="692275.N1QGX4"/>
    <dbReference type="GeneID" id="27902810"/>
    <dbReference type="eggNOG" id="ENOG502RYJ5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010103_3_1_1"/>
    <dbReference type="OMA" id="YCEAIRA"/>
    <dbReference type="OrthoDB" id="2684236at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009836">
        <property type="entry name" value="GRDP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34365">
        <property type="entry name" value="ENOLASE (DUF1399)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34365:SF7">
        <property type="entry name" value="GLYCINE-RICH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07173">
        <property type="entry name" value="GRDP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF11719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="779" mass="85658" checksum="B4AA54160477FDB4" modified="2013-06-26" version="1">MPTRLSRLFSSADKEKAELVEAERNPSSSPSTGDAPPSYQGQDHYDREDSIPPPDITAGFSNLSVSPSGDGFPTKTECIAHLKVLECFYRLKQSIAAHDGLFGIDNALVTGAPVPQNDKTPELLAKLGEKRWAIYVQQAVDRFEAWWKAIRPHSRMADRSQLVFEAKQGTLCDPGDDNKGPLFDDSTLPPADVLMVWHAYMLNPRCYLEDCIRQGKLDVWRASFPWEIVAQSINSETFVCEATPAAKTHFSKLTGLQWEGMTDIKARPTLCPACSTVNHVPWTTQIVSLGYPNTPTRLEAKLDEILSSGQGFCDKDLRHRCTGCPTYITHDRLRLTKFANDVERAQVNNIPMSGTILGLQGIPWEAHGRTDSTTDAISSFPNQMIRITTRSGQYSRNGPNRPFNAWDIRCFDTFGEVRWLVETTLKNKKHMRAARGNRAHRLERTERIAIRKMMSRYWDNSSPFALDLVGAVVRQGSFIEKMHNIDWLHSPALPSTMERLVRKYENFMTIMAQNPTRMAVPTLDVDLAWHTHQLRPSYYMQYTVKRCKQFIDHDDKVAETKLNDSFAWTSKAYQRLTGQPYSECTCWYCEAVRESHTSAASRIFNTTSAQASSAVLHVSEQDPAKSVHISSHNAVRPIDVKYDLESKRHALELDNHYLKACERAKKKGRPAPKRNDYYYSDAYGYPVYIPAYSPYGGFVPYAPMYYPVTPGCMAVSEGAVGNCCSGTCGGSVAAGSCAGAGSGGCAGGSGGGYSGCGGGGGGGGGGGGGCGGGGGGGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1QH19</accession>
    <name>N1QH19_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_151384</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757430.1">
        <property type="nucleotide sequence ID" value="XM_016906779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QH19"/>
    <dbReference type="STRING" id="692275.N1QH19"/>
    <dbReference type="GeneID" id="27903916"/>
    <dbReference type="eggNOG" id="KOG1290">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_81_1_1"/>
    <dbReference type="OMA" id="EPLWIYR"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="65"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF09309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="423" mass="48389" checksum="B8AE347680CE94DB" modified="2013-06-26" version="1">MAVSSCLARSRTRLASLLYYAPWSPSTAIAPRLDPNKPIEEEQSPYYRHDFFHPTRLWDILNSRYQIVAKLGHGSGSTVWLARDLRRFRWTEEKFVVVKIGANRQASLGHGVKDELAILRRLTDGNRQHMGWNFVRKLRDSFTLGSPNAEHRCIVSEPLREPLWMYCQRFVGNVIPPNVVKVLIRMILEGLDYLHSQCQVIHTDLKTDNIMIRFEDPAIPAEVADDEYHHPLPQKHLDDGRVIYLSRNGFGPLREPTGMICITDFDRAVLGTEAHSGCIQADIYRAPESILDAGFSYPADIWNLGVMLWDLLEGDWLFQVATKGTHEYDDSLHIAHITALLGPKPDTFPAGQRTAMFYNPNGNLKHPELVPQDFSFESAITCMEGEEKRLCIEFVKRMLKWLPQERSTAKELLHDPWLHTGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>N1QHD6</accession>
    <name>N1QHD6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_133828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759970.1">
        <property type="nucleotide sequence ID" value="XM_016902590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QHD6"/>
    <dbReference type="GeneID" id="27899727"/>
    <dbReference type="HOGENOM" id="CLU_625799_0_0_1"/>
    <dbReference type="OrthoDB" id="1334205at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="423"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF11849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="438" mass="46168" checksum="BF00DECD3A81C9D8" modified="2013-06-26" version="1">MSLLIRIRKKLERKLLHKPGQHGTPVYYAPADDEVEEISTTRTTTTTPPTATPASSRPSSRLPSLSFLSSSRRHSSQQRRQSSTRSPTTTTPTDNHPSPHAPPRSPSFFCRGSSSHHARNGSNLSSITGPGGGGGRRSETWTSATTTTDHDNEECFRFPVFPDSGYVSRESNPDVGFVVPDSPHQSLANPSQLGNAMTIGGGIGNGNGNGEDRSIKPPRRESPPFSRGVSCATTTTTTTTTKGREESRASSHGNELPSSAYSATTAALSPSLISDRYEAPSAMSPNEDFISGRDSTATAAEGLRGFEGVRGGKVRGGGGGNPRFDDDGGHDDVDDVDVVDYGLFPAPPPPPPAAAPAAPARPPVAAARPGPSARSQTAAAAAAPPPPPVVGNGSRTARTRNDDVRRDRRPRLDDARRDRRPFTTTTALTGYGYTTGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>N1QHL8</accession>
    <name>N1QHL8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Riboflavin kinase</fullName>
            <ecNumber evidence="4">2.7.1.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Flavin mononucleotide kinase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SEPMUDRAFT_35314</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) coenzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>riboflavin + ATP = FMN + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14357"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the flavokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.26" evidence="4"/>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764857.1">
        <property type="nucleotide sequence ID" value="XM_016908608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QHL8"/>
    <dbReference type="STRING" id="692275.N1QHL8"/>
    <dbReference type="GeneID" id="27905745"/>
    <dbReference type="eggNOG" id="KOG3110">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048437_3_2_1"/>
    <dbReference type="OMA" id="NGEVHKM"/>
    <dbReference type="OrthoDB" id="2538135at2759"/>
    <dbReference type="UniPathway" id="UPA00276">
        <property type="reaction ID" value="UER00406"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009398">
        <property type="term" value="P:FMN biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="entry name" value="Riboflavin kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023468">
        <property type="entry name" value="Riboflavin_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015865">
        <property type="entry name" value="Riboflavin_kinase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749:SF6">
        <property type="entry name" value="RIBOFLAVIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749">
        <property type="entry name" value="RIBOFLAVIN KINASE/FMN ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01687">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00904">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="Riboflavin kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="10 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Riboflavin kinase" evidence="15">
        <location>
            <begin position="18"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMF16736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="213" mass="23166" checksum="1DA6298D1E08B4F9" modified="2013-06-26" version="1">MRPDGPRPAIVGNDAGPEPPFPLKLDGKVIKGFGRGSKELGIPTANIPLSGLSVGGHEDLESGVYYGWAGLSPSQAVRQHLSGKKSDYKLMSPDVYSALGSSQSDLSAISADQGAVFPMVMSIGWNPFYKNTVRSVEVHIMRDFETDFYESHMNLLILGFIRPELDYVSKESLIEDIKTDIDVAGRSLSRPAYANLARDPYLVEFEGKGELAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1QHW3</accession>
    <name>N1QHW3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_151545</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="7"/>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757695.1">
        <property type="nucleotide sequence ID" value="XM_016906883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QHW3"/>
    <dbReference type="STRING" id="692275.N1QHW3"/>
    <dbReference type="GeneID" id="27904020"/>
    <dbReference type="eggNOG" id="KOG0371">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004962_0_5_1"/>
    <dbReference type="OMA" id="EGYNWGQ"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000003">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="8">
        <location>
            <begin position="144"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF09574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="339" mass="38403" checksum="365F700438A0C837" modified="2013-06-26" version="1">MAEAAALRQQPAMGDTAMEDAGKIEHSLGTPIDPPTIPTLDGWIESLMTCKQLAEDDVRRLCEKAREVLQDESNVQPVKCPVTVCGDIHGQFHDLMELFKIGGPNPDTNYLFMGDYVDRGYFSVETVTLLVALKIRYPQRITILRGNHESRQITQVYGFYDECLRKYGNANVWKFFTDLFDYLPLTALIDNQIFCLHGGLSPSIDTLDNIRALDRIQEVPHEGPMCDLLWSDPDDRCGWGISPRGAGYTFGQDISEAFNHNNGLTLVARAHQLVMEGYNWSQDRNVVTIFSAPNYCYRCGNQAAIMEIDEHLKYTFLQFDPCPRAGEPMVSRRTPDYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1QI38</accession>
    <name>N1QI38_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_129719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764981.1">
        <property type="nucleotide sequence ID" value="XM_016902305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QI38"/>
    <dbReference type="STRING" id="692275.N1QI38"/>
    <dbReference type="GeneID" id="27899442"/>
    <dbReference type="eggNOG" id="KOG2084">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028281_0_3_1"/>
    <dbReference type="OMA" id="CSGCDER"/>
    <dbReference type="OrthoDB" id="265717at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053185">
        <property type="entry name" value="SET_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332:SF4">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="32"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF16860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="449" mass="50520" checksum="4F0F916CBA370CAE" modified="2013-06-26" version="1">MAPYIYQTSNFAANNWLSARPDPISLLRGPSSHVQTRSSGEGRGLGLFTTRSIPAYSEILREAPLILLEPTDDLPQLYEQFISLRKPGSDEALQRRYLALSHQEVPQRDQRLREKLTERGFDAATVEEMVLVASIMQTNAFNVDVGNGMGCNYRALFPQIARINHSCVPNAHVCYYPSSTSTITAAEKTASSLHHHHHRRRQEGRMVVHALRNLHEGEEVQIAYFSILLSRPERQTKAQKWGFTCRCPACELLPTRHDNATDDDDGKSMRRHEQVRTAVVDFTTKKTALLMQQQQQQTKNHRTSSSSSSAVKQITNLITLGHNTISQVLDDEDDNDDNHTGGFHPTLPDLYSNLSELQARALLLLRSRERKSRPHQQHNEEVEKEDVISSLQLAAIWEAKLTGRESPATKKRLLQLEKCAARQDATTCSPRIVAGTGIGAYAIEWMSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1QI96</accession>
    <name>N1QI96_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_108951</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760285.1">
        <property type="nucleotide sequence ID" value="XM_016900755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QI96"/>
    <dbReference type="STRING" id="692275.N1QI96"/>
    <dbReference type="GeneID" id="27897892"/>
    <dbReference type="eggNOG" id="ENOG502SIT3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028422_0_0_1"/>
    <dbReference type="OrthoDB" id="435881at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF77">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="5">
        <location>
            <begin position="333"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="139"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="183"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="616"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="110"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="618"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="645"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="657"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF12164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="712" mass="79109" checksum="A8CB8C9CB2641A45" modified="2013-06-26" version="1">MSATHELITSDALVSLLGQHSAAGPHFDSAKPSVADQICARALITAATNILPSHFQLMRILIPYMHSGPQMESYLELQRRKILAGNNGRTSPLGQNAIVAVREPTRFSDVTNEASTVSALEEQIQKLAERLAAVETKAEATATWARDSESTSRPTSRQTHRRSASSMSLSRLSFVEPTIPELEEASADKPETASFPFNTSKRPESPREEDLTPKRLWAMWQHYRSNVDPLLKIVHIPAVQHLFLSTDEESKHVSADAESLKFAISFAAAASLETPPGDATSCANNQVLLHTYATKLEASLAKAQFMKEPTIAAVQALTIYLITGQRFLGSTYVWSLMAILVRVATKLKLNQDPENQGLSFLDCEYRRRLWWHICTLDARIAELNHSDPLIYERKCTSRFPISIPDTDLDSVQDIDPKRSATQHSPDMFSNLLRFEITYYMRTILFSEDFMEENGWPILPVDGKLSVIEYLEKVLEDKYYRTCDCKTSTCRLAIASSRITVARLKLSTLLGEQGVSQLSKDEMDEVLAASAIVLENLRTLRDDPSLSRWTWLSTPQAEWDAAAMCLSALLLVRSKTKAVTRAWTALNTFFVAWKESSYDPALYKKWVRLEGLKTRAEASQRQTASESSASSQTSNYTAYTPGASLSPVTTRATPSQRSASPSTKTAPASQVGSVSSKSSGSARSAFSDQDWPFPKEALQEHAEFDLQSFALMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1QIK2</accession>
    <name>N1QIK2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NADH dehydrogenase, alpha subcomplex, subunit 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_86708</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I LYR family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759766.1">
        <property type="nucleotide sequence ID" value="XM_016910420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QIK2"/>
    <dbReference type="STRING" id="692275.N1QIK2"/>
    <dbReference type="GeneID" id="27907557"/>
    <dbReference type="eggNOG" id="KOG3426">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111660_0_1_1"/>
    <dbReference type="OMA" id="FWKQTTH"/>
    <dbReference type="OrthoDB" id="14535at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20266">
        <property type="entry name" value="Complex1_LYR_NDUFA6_LYRM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045299">
        <property type="entry name" value="Complex1_LYR_NDUFA6_LYRM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016488">
        <property type="entry name" value="NADH_Ub_cplx-1_asu_su-6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12964:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12964">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B14 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13233">
        <property type="entry name" value="Complex1_LYR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006643">
        <property type="entry name" value="NDUA6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF11645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="124" mass="14783" checksum="B76AC3433A1A9843" modified="2013-06-26" version="1">MVINPTYLAQRTRSSATWSDAKQRVLSSYRDWLRAAPEVQTMYSLNMPVSKIRTKVRQEFERHRYVNQLKTVDVLLFNSHQEFQETLNFWKQLTHVLKYFRAEEDPKGSTLPKNFIQGFIEGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1QIL2</accession>
    <name>N1QIL2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_160380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765146.1">
        <property type="nucleotide sequence ID" value="XM_016907893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QIL2"/>
    <dbReference type="STRING" id="692275.N1QIL2"/>
    <dbReference type="GeneID" id="27905030"/>
    <dbReference type="eggNOG" id="ENOG502STYS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058869_0_0_1"/>
    <dbReference type="OMA" id="SHPPGYQ"/>
    <dbReference type="OrthoDB" id="5385910at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF17025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="245" mass="25045" checksum="5C5ABBE34EB9F88E" modified="2013-06-26" version="1">MPPIQPIPVHIDAPITPQQQRTNNPPARPGAAAVPAPTGTPYTPNQYPPQPTRTTAAVYDDSPPPPQPGAVPIPPSQQHGAPVTAIPPPPKAGQTATLHEQGQAVTTQPPQMDVNLAAQGYAPTHSTSTTNNTPMKLGLGPTTLNYGLVSPGGGGIAAPSHPAGYQQNSMAQEMSSAARASLDATERRESLTGGFGMGSSATGSLPSVGSGGTKGMWDAVKGWTSTVGQTLAETEKKVWDSVNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1QIW9</accession>
    <name>N1QIW9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_75118</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764333.1">
        <property type="nucleotide sequence ID" value="XM_016910098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QIW9"/>
    <dbReference type="STRING" id="692275.N1QIW9"/>
    <dbReference type="GeneID" id="27907235"/>
    <dbReference type="eggNOG" id="ENOG502S0M5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041181_1_0_1"/>
    <dbReference type="OMA" id="RVIATYI"/>
    <dbReference type="OrthoDB" id="2117459at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39466">
        <property type="entry name" value="RGS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39466:SF1">
        <property type="entry name" value="RGS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="324"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="422"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="3">
        <location>
            <begin position="214"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF16212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="450" mass="50696" checksum="CD01CD431966CA83" modified="2013-06-26" version="1">MVYSLAYRRPPHVPGSSQRSLNGHEKQPSINDSLQSGTSGMSHGIPAALSFDRIVTGGTCPPVTLREFMNYLKYIEYSAENLQFYLWYRDYASRWEQLKDGDRALAPEWKTNAEADLPLSPPRPNRLAPQIAQVLKDSDFTKTSKPAVERVDPFNTPQTISLDERQENGSDYASSVSDEKTLLSSGNGNNHRLVTDQAFGEAGLKWKPFTTQPYRDEVSRIVSIYIAEGSPRELNLSSRERQAVLHALQHTTHPSTFSAIITSVEFSLRKQAHPNFIRWTICNGNRPRVLFARGLGLSLMLIGLVADILITLSSAGRGWRVLPIVAWLLGISTLIAAWKGMCVVLHGLHHRHVRPWELFSDESEEALNEKWASKESLAASTRNSFEQEPWVPRYKQRNIIRKILDREVWIQEPALRQIQDTIFLQSLLGALVASAIIVGIFCALPHGNFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJ26</accession>
    <name>N1QJ26_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_57418</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765347.1">
        <property type="nucleotide sequence ID" value="XM_016909434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJ26"/>
    <dbReference type="STRING" id="692275.N1QJ26"/>
    <dbReference type="GeneID" id="27906571"/>
    <dbReference type="eggNOG" id="KOG3298">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085878_2_0_1"/>
    <dbReference type="OMA" id="TMRQPGL"/>
    <dbReference type="OrthoDB" id="1162399at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990328">
        <property type="term" value="C:RPB4-RPB7 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060213">
        <property type="term" value="P:positive regulation of nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045948">
        <property type="term" value="P:positive regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010590">
        <property type="term" value="P:regulation of septum digestion after cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04462">
        <property type="entry name" value="S1_RNAPII_Rpb7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000043">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF4">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4 6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="S1 motif" evidence="5">
        <location>
            <begin position="81"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU369086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF17226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="171" mass="18993" checksum="0AF58329E349E556" modified="2013-06-26" version="1">MFFVAHRVRECTLHPSFFNSGADAQVRQRLYEDMEGKVEGTEMIVQIIEIDEISEPVLVPGTGMAKYTLSYRAIVWRPFRGEVVDGMVTSVVNNGFFVDVGALSVFVSKAMIPGALKYTVEGSTPSFTDNSDQTIERGTQVRLRIKGIRGEMGSMYAIGSIREDYLGPLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJ77</accession>
    <name>N1QJ77_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_130063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765407.1">
        <property type="nucleotide sequence ID" value="XM_016902329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJ77"/>
    <dbReference type="STRING" id="692275.N1QJ77"/>
    <dbReference type="GeneID" id="27899466"/>
    <dbReference type="eggNOG" id="ENOG502SFYT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1074292_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF17286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="259" mass="27561" checksum="D04CCABB8A20D696" modified="2013-06-26" version="1">MASVSPSDTTAHLPPEHLADSDVAIAATSVEQGDQTEPAVATAQTDTSIAIEDGDAPAPAPAPAASTSITGDAAEDSYPELEDHITLQPPPPPPHPPAGFKPYFTLLEDRITGEQHHPTVHYIFADDDPDLLTNAALETLLHTPHHHQQQQPDAEVASTERFMLVDMSADGQDIVSTSSLSADWQSFESSLAQAPSWGNDSASTQLMLRISGQGSLPVLRRGRGDQRRMDDVAGLTRLLDDVQMDLESVVVGNAGHTTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJF2</accession>
    <name>N1QJF2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_152643</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764538.1">
        <property type="nucleotide sequence ID" value="XM_016907477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJF2"/>
    <dbReference type="STRING" id="692275.N1QJF2"/>
    <dbReference type="GeneID" id="27904614"/>
    <dbReference type="eggNOG" id="ENOG502RK32">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_408929_0_0_1"/>
    <dbReference type="OMA" id="RGYFICL"/>
    <dbReference type="OrthoDB" id="5279008at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="28"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="580"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="665"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="580"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="665"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="697"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF16417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="709" mass="77023" checksum="588DD75CAD0D1D25" modified="2013-06-26" version="1">MADARLPMPSAAEHSNTGSTGSLSPNAGSLLAMLPEELLINISIKLQSDDIFALRQTCRAIETKSLHEFANEFFTEKCFMYTTESLKVLVNIANSEKLRGYLRHIYLITALVKERPKHCPHHCLGHCWHPNVRQQEAFTLYLRDQQALRQNKAAKPFLVDAFSKLPRLTGLSLVDNTLEVPLSAEVRGLSKFQRTTGTIPHYAPPESATPPALLEHFDWQSHCWRSLMVAVAESGIKTLKKVETKMRSHLHGISPIDDLKFKSSTMGKLQDAFAELETFSVQFRSYAMRKNRSDGNSSMTRARKGLAEFTPILSHVTDFSVSFDLADQNSSMCKTLTSALDLSKLKKMKLDSTAIDGKVLGTILAGLTSVEMLTLHAIDLTSGNWVTMLKILKQLPHLQHLHLVYLQQSRQKVYFLKQLDEEQSANESAWEPMPDDMPDDMEDDDDDDWSEDYGSDDDEELPDLIPQETSLPDSIHMASAEEQSASGVESEATKKCAMYEDKDYKAPGQERLPERGYFICLPSRDEIEKQLPLFIEECNVGQDIMEDEIAGLGGLNGLLAALGGPVGGPGGIVLPVPMGAPPPAGQMQPPPPAPPVNNPPPNANGPGGQAGGITIAAALNHLFTGGGQPGHGHMQFTIPMLNTPNHQGAGVPPTAGVEEQAVPGATNVQAANANVAASGPDTDAASASFSGAAHQDDADDENDAANDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1QK41</accession>
    <name>N1QK41_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_103997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764753.1">
        <property type="nucleotide sequence ID" value="XM_016900526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QK41"/>
    <dbReference type="GeneID" id="27897663"/>
    <dbReference type="HOGENOM" id="CLU_1008904_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF16632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="276" mass="30667" checksum="BBDB7E8A5189F9DD" modified="2013-06-26" version="1">MTHRNNTSLLPADSSRARRYDVTIYDTASPANAFHISAFSGTSYLSRSRRPDSFTSWTEFLSLVGDLQDRAEQRRLFTRRPASETFRRGRGVQSAPVSIISSKGGAPRSYSLDPLRRSGIKREPHIGSALVIQSPKHPPTGTKFEPEPLLVSGDAESRHPSVTTTNDDRQTRYRRYACASGVPGCQDEDDRIPTHATHPLAHTHCPSPGVTHRAVGKEDLPNAKRERDSSSRSAIARVVGQRTERVAWLASVQRERAHLTVPDGIKKRMPRAQCAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1QK96</accession>
    <name>N1QK96_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_149562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759747.1">
        <property type="nucleotide sequence ID" value="XM_016905631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QK96"/>
    <dbReference type="GeneID" id="27902768"/>
    <dbReference type="HOGENOM" id="CLU_790279_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF11626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="351" mass="36264" checksum="47CAF84F64BA1650" modified="2013-06-26" version="1">MFISSILIITTILQGQQRQGIIVHAAKITLTQEIQITTTIHVSPTTTSTWTLLLEEGSTLLPPLTALVPVSGPGTLATTTGISILGTYNDDDDDDAVSPSSHHYYHQTPTQTSTLTRDSASYQPSSFSSSSTTNTPASKVLLIGSDNGSASALPLTAGGSAQTISGTRYSLDECRLFVDTTKTAMLGYSGRECEPTTTTATATATATSVIRKIWTSTRTVPVEVTSKVIMMPAAAAAAGGGRLYAGVNSTRVGIGRNHTLATTTTSSAAAAATTATKGIVLLGAPLAGQRNSTMTRSRAPWTSTSSSSSGITASGSATATSQSGASFGCEVDRRILVWWLMMAGVLFLLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKC0</accession>
    <name>N1QKC0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sterol regulatory element-binding protein cleavage-activating protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SEPMUDRAFT_153560</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat SCAP family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765792.1">
        <property type="nucleotide sequence ID" value="XM_016907515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QKC0"/>
    <dbReference type="STRING" id="692275.N1QKC0"/>
    <dbReference type="GeneID" id="27904652"/>
    <dbReference type="eggNOG" id="KOG1933">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004183_0_0_1"/>
    <dbReference type="OMA" id="EFQFRPM"/>
    <dbReference type="OrthoDB" id="1914839at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032936">
        <property type="term" value="C:SREBP-SCAP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045540">
        <property type="term" value="P:regulation of cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032933">
        <property type="term" value="P:SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030225">
        <property type="entry name" value="SCAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46378">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46378:SF1">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="15" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="295"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="364"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="394"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="587"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="17">
        <location>
            <begin position="264"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMF17671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1144" mass="124708" checksum="60D730508B6D8126" modified="2013-06-26" version="1">MLWYLLSPLRGTTQPPRLSPSHPVRRAFYRHGKTTSQHWLMAMLVTVAIAMGFSYPTIFLAENPTAGLAAYPHHAWTTVRPIANGSAAVDIELRQIWVHGSYMNALSKDVLKRGLAVQQRLVGHEALGDTMHSLDDKLRSSAVPWAFHSPLMYWNNSAELIDADQNILSTINDQKHSSSSLDVALRPASVFAGKEFDRNKLRAADALVITLMNKGGGAMGDRWHDKMQTLADGACPGCTLFPADGNVTRNRVYEFSFTPLSISAHLALTVAYSAMAIYVLLSFRRLRAFHSRGGLVVTAITQMTCSILSSFTICHILKINLSTIPQNAYPFVVLVLGVENIFRLINAVLAYSPTMATELRIANALGDIGPVSVAAAAQNLTVLALLSTVVSPGVAAFCAFAAIATLFDSFFLLTFFVAVLSVDIRRLELQDAIAARHHKSRREKQSRATPHHTWMDALFQGRLPFSTRMAGTAVTATFVLSLNYHFFERKGAGATIRDVLNLMKSGSGPLTEDTFAPPPMNASLTPTEWMRLQDFDTAKEVMRLAKPGADSFVICLFAPLIVVLGGSDRTAVGSQAWTDTLRSFAVHHFYPVIVAIIFTVAFVMLLMNFLLYNAGDEDHDLALEPMEDTLTCDTVVLPHRLDIVKMATSDTGHVITVALDRTIAVTVVDTTQQSYRTFALPAHVLQQISWPIRHLAIDDAGEWIACHCSDDRILVYNLTHGSIMSNVTQYPDDHGARVFTFVSLPSSDGMKLHLLVLTSGGRLAMSCFETGLSQGNDLSHLPLMGAAIVDTLQGRQLYIVGMEAHIKAYTWTGSNWAVTNTAQLQIETETGHLGAHLTEQVEIQSYRDLDTELIVVTTSASAIFLDSLTLAPIAKFDFETGEKDGKRGLASRECVGVRSGGKLLMGSSRLCSACGSLALRRAAIASDRPDREDVCIVRTWSINRKDDDDDDDDDDGEPCICLAQRSASCHAFSPENYDTYSVPSPGVWSTTAKDQVIIGLRKRPLQGGAPGKIDTYASSNGREATPAQLRQRRRDLRQRAAQLDAGEDQVWEAYKLSIDGDLQILELPPPETDALYVHNAGPVHPLDCQSVVVAFGNCIKVIRSARRATGVSSRSSTITTTASTAAAAAAAATATTTSALLYNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKQ0</accession>
    <name>N1QKQ0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_149654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759887.1">
        <property type="nucleotide sequence ID" value="XM_016905691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QKQ0"/>
    <dbReference type="GeneID" id="27902828"/>
    <dbReference type="eggNOG" id="ENOG502SXQE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1100718_0_0_1"/>
    <dbReference type="OrthoDB" id="3650809at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF11766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="253" mass="27917" checksum="BA648AAD1FC77A17" modified="2013-06-26" version="1" fragment="single">MPLELVAIIVKSYPGSVKYETTIRCEIPITVRRRPDECASLRAFDQLPSPAKRFLHKASYEHLRAPWTNVEVRMVPEIPLDVNFGSTHVNRRGELASDSEDGSPMKSPKAIDVTLPPLKSPLFNRSPPTSASRSTPHSERFVISPIGHDEHGGRRSESIDSWLGSEVRLPIRSRGSRSLFAATSPYGRAKHSRQHHGREEPTAGSADTRVTSPQKRQAAACVDHVLAKKSSALAGADENRLTQSREESIDDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKZ0</accession>
    <name>N1QKZ0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_34446</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765986.1">
        <property type="nucleotide sequence ID" value="XM_016908569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QKZ0"/>
    <dbReference type="STRING" id="692275.N1QKZ0"/>
    <dbReference type="GeneID" id="27905706"/>
    <dbReference type="HOGENOM" id="CLU_042941_6_0_1"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF14">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF17865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="209" mass="24778" checksum="DF519BB2FB281F14" modified="2013-06-26" version="1">MGGDLWGNKSNIFEQDPSPAVDKAWETITHAKYTLMPEAELLKMDFSVEAAVEWPDQPGKYMVEFHAYHVMHCLDVVRKNSYHNFPHYYNPETLNAIHWTHWTHCLEILRQELMCMPSMHLGRMVWQQGQSQAFPEFRTNRMCMRWEDFDDMVTSIQLPEEVSYINGAFFFFFFLFFFVFLLTTRGNSHLLFLVRNKSRDQRTQACGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1QL15</accession>
    <name>N1QL15_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_146852</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016766077.1">
        <property type="nucleotide sequence ID" value="XM_016903908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QL15"/>
    <dbReference type="STRING" id="692275.N1QL15"/>
    <dbReference type="GeneID" id="27901045"/>
    <dbReference type="eggNOG" id="ENOG502SU16">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_946590_0_0_1"/>
    <dbReference type="OMA" id="WASPECA"/>
    <dbReference type="OrthoDB" id="5215637at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109958" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF17956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="31844" checksum="79EC5EFBE97F1EE3" modified="2013-06-26" version="1">MRTATVTLLLTSASAILAATTPQQCYFPDGSESTHTPCNATAAAAKGGFSACCSDTSYCMDNGLCLEAGILTRMSCTDKTFADTTCPQYCNTDNMGDPYELTPCTATTFTCGLSPANCSVATTVFPVTDLKNIVLQADQLVTAMSAAGIATASVDPTVSPTETVPVLTVTATGDLKPANPALQYTTGQLVGVGAGVGIPMALAIGVLSFFLLREKKKHKISEINEGGFRPAPPTMETRDGNSWSAWSETTKVGGTSDYGRRPSKSNTHHLQDLDGEGRDRNQFSAQHSSNAPDGTWRSNDNMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1QLM1</accession>
    <name>N1QLM1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6699 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_129517</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764724.1">
        <property type="nucleotide sequence ID" value="XM_016902290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QLM1"/>
    <dbReference type="GeneID" id="27899427"/>
    <dbReference type="eggNOG" id="ENOG502S5UU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078844_1_0_1"/>
    <dbReference type="OMA" id="GIWNIKD"/>
    <dbReference type="OrthoDB" id="79687at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046522">
        <property type="entry name" value="DUF6699"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20415">
        <property type="entry name" value="DUF6699"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6699" evidence="2">
        <location>
            <begin position="69"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF16603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="181" mass="20097" checksum="FF364945C5395DF0" modified="2013-06-26" version="1">MSAEVQEPLSTLSKVDSAIDDAPASPTESKIRHRRTSSTVSGVFNINDLEKEGVELKIAPETQKLGWKLNTSPSKVEDQEVLKKLLCNPPIKKIDLHFPLGLEVTARNSKGVTIKDALDAIHKQFKKKADDELEAPYLAGFEWDREECYTKFIVHQKRNAEVAPSGSGKKGKKGKKDNEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1QM72</accession>
    <name>N1QM72_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Repressor of RNA polymerase III transcription MAF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_146098</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mediator of diverse signals that repress RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765104.1">
        <property type="nucleotide sequence ID" value="XM_016903454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QM72"/>
    <dbReference type="STRING" id="692275.N1QM72"/>
    <dbReference type="GeneID" id="27900591"/>
    <dbReference type="eggNOG" id="KOG3104">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037043_1_1_1"/>
    <dbReference type="OMA" id="GCDLWTV"/>
    <dbReference type="OrthoDB" id="277029at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000994">
        <property type="term" value="F:RNA polymerase III core binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016480">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1000.50:FF:000004">
        <property type="entry name" value="Repressor of RNA polymerase III transcription MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.50">
        <property type="entry name" value="Repressor of RNA polymerase III transcription Maf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015257">
        <property type="entry name" value="Maf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038564">
        <property type="entry name" value="Maf1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22504">
        <property type="entry name" value="REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22504:SF0">
        <property type="entry name" value="REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09174">
        <property type="entry name" value="Maf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037240">
        <property type="entry name" value="RNA_polIII_Trep_MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="71"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR037240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF16983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="377" mass="42711" checksum="9150445A588CAD0D" modified="2013-06-26" version="1">MKYLPVREIDIVTNALNFSTPDTHLIGGCDMYTTKAAGGDKKLYKNIENSLESQYESLVRLSASLSPPRHAPSDDGHGSERIESRRRGCTVEAPEIDLSRASPFGPLSQITARRTFAYLIATLNASHPDYDFSRLLRPSDFNKQRSLRSMMHKLDSTLQHLRPRQTTTSNYLVPSSSLSSSAPGPGGNDIWNQNMWRLIDKEMGLRQCEKYTYDPEDDPFDGDEGAIWSMHYFFFNKEKKRVCYIYLRAFSVISHSPLQAAITLHRPKPASRKVSSLSVGEGAEKRAAFWLSSDMLRSIDTISYGEDDDDEMIEVHDDDDDESEVPPFDLEDFRNGLSDGSFSYSVDEYAGESDNDWTSRELRDMSEEIVSNMDMEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>N1QM75</accession>
    <name>N1QM75_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">60S ribosomal protein L5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_138089</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765518.1">
        <property type="nucleotide sequence ID" value="XM_016902862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QM75"/>
    <dbReference type="STRING" id="692275.N1QM75"/>
    <dbReference type="GeneID" id="27899999"/>
    <dbReference type="eggNOG" id="KOG0875">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056222_1_0_1"/>
    <dbReference type="OMA" id="CQIASAH"/>
    <dbReference type="OrthoDB" id="8436363at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00432">
        <property type="entry name" value="Ribosomal_L18_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.100:FF:000002">
        <property type="entry name" value="60S ribosomal protein L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_A">
        <property type="entry name" value="Ribosomal_uL18_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005485">
        <property type="entry name" value="Rbsml_uL18_euk_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057268">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025607">
        <property type="entry name" value="Ribosomal_uL18_C_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410:SF12">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410">
        <property type="entry name" value="RIBOSOMAL PROTEIN L5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14204">
        <property type="entry name" value="Ribosomal_L18_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17144">
        <property type="entry name" value="Ribosomal_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00058">
        <property type="entry name" value="RIBOSOMALL5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL18 C-terminal eukaryotes" evidence="7">
        <location>
            <begin position="239"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="250"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF17397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="302" mass="35004" checksum="61C64B2EA4F26E4C" modified="2013-06-26" version="1">MPFTKLVKNSAYFSRYQVKYKRRRSGKTDYYARKRLITQAKNKYNAPKYRLVVRFTNRDIIAQIVTSELTGDKVFVAAYGHELKRYGVTHGLTNWAAAYCVGLLIARRALNKLELEDTFTGVEEADGEFTETQPEEVDGETRRPFKVFLDVGLTRTSTGARVFGAMKGASDGGLYVPHSEKRFPGYDIETKELDAETLRKYIFAGHVAEYMETLADDDEERYKSQFSGYIDDEIEADGLEELYQEAHKAIREDPWKKDEDAGEKKTKEEWKAESQKYKLKKLTHEERRQRVQEKIKTLAQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1QMF0</accession>
    <name>N1QMF0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_160026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764710.1">
        <property type="nucleotide sequence ID" value="XM_016907875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QMF0"/>
    <dbReference type="STRING" id="692275.N1QMF0"/>
    <dbReference type="GeneID" id="27905012"/>
    <dbReference type="eggNOG" id="ENOG502RY95">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008869_0_0_1"/>
    <dbReference type="OMA" id="HVVHSKI"/>
    <dbReference type="OrthoDB" id="3248508at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842:SF3">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="557"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF16589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="682" mass="75897" checksum="FD66D44A37CD5D84" modified="2013-06-26" version="1">MSPRLRAPPLPPRRPSTAVSHMDEPPPYEAVAHQQKAFEKASALAGLAQNDPRSSSQDSLVPEEGTQQQRRKLLLVYIHGFMGAETSFRSFPAHVHNLLTVLLSETHVVHTKVYPRYASRGKISIARDDFGKWIEPHQDATTDLVLLGHSMGGLLSAEVVLAPAIRSGSGPFRHRILGTINFDVPFLGLHPGVVKSGLASIFKPAEEPRDQDIGGGSHTSSSEGSQVESRPQIPSPTPSAQRVDTLWAPGKQDPNYNPSFANDVVLPVRKGWRNAWHFINKHSDDLTQATKKLVSSHLEFGGAMANYGELKSRYARVRALEEVDGRVRQSVVEGGVPPRVRFVNYYTASTGRFKKPKSPPRESSRSQHGSRSLSPADHPPDLHARTSTDSVATRRSDEEQWEEAMESMTVGDAAEAEGVLENNTAKKADQASMTLPDLPVKPPAQVDFSYIQDPEIKKLVQREHDKAVKAYEEAIGKQRQLEDPVHQSRSEEPRGRPAVSHERAKKPESEMTHSEREHLRLEKEQHRMEREGRRMRGERSPEPGQSSNPDTIPMVVTPPRESSPRPSTTASTVDTSFTYDQSSLAPAAKSMTSVNSKEESHKPRKDRMFCTLPPKDANGERDPRWVRVFMENVDEVGAHCGLFFVDERYERLVGDVASRIEGWVNDETGDAISKPPSQPQKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1QN14</accession>
    <name>N1QN14_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_146490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765589.1">
        <property type="nucleotide sequence ID" value="XM_016903686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QN14"/>
    <dbReference type="GeneID" id="27900823"/>
    <dbReference type="eggNOG" id="ENOG502SIH3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036233_0_0_1"/>
    <dbReference type="OMA" id="NMISPSY"/>
    <dbReference type="OrthoDB" id="5413188at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF17468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="429" mass="46332" checksum="966AAABCA0F8ECE3" modified="2013-06-26" version="1">MNPHPPHSSDHCQRPPGHASAMASRPTSFDRRTRPEVDSWVEIASQPSSSSLSSIGDDIVTTGLRVRGDQRTRRRRARQPGAPTPLNVVRTHSLGGTSSQEEYEESESESDRVMTSSNEGPVLAANTFPSQRADGASALHSSASEEERGGGSDDDDENRTAINYPIHNENSFTPLPNAFSHPPTGQRRNSTQQVSGSYFPAAPAHRPSARHLFPAATEARRLSHVPQNPLSPSFNAAVEHDEALKASLQSLLSVAAAARGLKGEGKHPTSTSAPLRSNRIDPTTFRMIPQSALENTPSPQVQEPTFKPTIRRTSTQSTATTSDQKEGKRKAVVGRNSSRERRSLKKARRSESREDLHVTPTLLTWVVSAGVVVFLSALSFSAGYSVGKEAGRIEASSFAADEQLRSCAREAGRSSLGLKRSLARSAIQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>N1QN22</accession>
    <name>N1QN22_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein transport protein SEC31</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein transport protein sec31</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SEPMUDRAFT_77800</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">COPII-coated vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat SEC31 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765604.1">
        <property type="nucleotide sequence ID" value="XM_016910173.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.N1QN22"/>
    <dbReference type="GeneID" id="27907310"/>
    <dbReference type="eggNOG" id="KOG0307">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003033_2_0_1"/>
    <dbReference type="OMA" id="WLERPCG"/>
    <dbReference type="OrthoDB" id="542917at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007029">
        <property type="term" value="P:endoplasmic reticulum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000193">
        <property type="entry name" value="Protein transport protein SEC31, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040251">
        <property type="entry name" value="SEC31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923">
        <property type="entry name" value="SEC31-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923:SF11">
        <property type="entry name" value="SECRETORY 31, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="834"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="848"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="878"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="971"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1002"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1075"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="1088"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1098"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="1113"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1137"/>
            <end position="1151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMF17483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1286" mass="138225" checksum="3A25FD62FB08F75A" modified="2013-06-26" version="1">MVRLREIPRTAVFAWLPGSGAPLVVTGTRAGAVGDDFSSEIKLELWDLRLNELHADGELTPAGSITTDSGFNDIAWSAPDDNHPLGVIAGALENGSVDLWDAQKLRNGSADAFISRTTKHSGSARALQWNPYRHNMLASVGAKGEIYIYDLNNMANASRLGASVARADDIECLDWNKQEKTAHILATGSSGGFVTVWDVKQKRDILTLNNQGRKAVSAVAWDPQESTKLATATSNDQEPLIFLWSLRNSSAPERTLKGHELGVLGLSWCVQDPELLLSCGKDNRTICWNPKTGERYGDFAAGSNWAFQSTWNPHNPSLIASASFDGKILITSTQSTNSKSEDQGSTNQVLDGEDFFAKAQSQPQGISFNLPKAPKWAERPAAVSFGFGGKLIRVGADASRKSKVSIDTYEVDSTIGEATVKFEEKLGSSDLKDILATKIADAKTDEEKSDWQVIDTLNAGSSRKQLRQYLGFEDSSSNDLSEATEKLAVNGDNQTNGTADDDFFGGGAGEDNFLANLAGSKGAKVNNPFKIYTGSESDADKSITQALMLGEFEKALDVCLKEDRMSDAFMIAVCGGQQCIDKAQTAYLKKKTDGPNYLRLLASIVGKNLWDVVHNAELNDWKEVMATLCTYADEKEFPDLCETLGDRLEEAFQSGDGPKTLRRDASFCYLAGAKLEKVVINWVAEFEEQEKDAQEKSESDSSFSVHAKCLQEFIEKVSVFRKVTKFSDTELQASADWKLAPLYSLYAEYADILASHGQLAAAERYLDLLPSKFAGAETSQQRIKQATKKATAAARQPAAAQRGGRMQPAVGTFQPIPTVQPAQAQPAPLINQARNPTASPYAPVGMNATAQQSTNPYAPSSNAYAPSGYTPAQTPLSYGQPAYGGYQAPQQQAALPPPPRGSTASPAVLPAALSKKTGDWNDMPEGFLDKRQPTPRRNTPGPQPVAAPFPGAQNVMSPPPGPPTAYGYQKPTPPLPPPPKAGEGPPRVTSPLAAPMPPPIQRPSSAANAYSPQMPSQSQGSTLPMPAAPPVQRGASPYQPPPSISSATPSNRYAPAPGAQPSALPGQAPQHRNVAPNPYQAQGQPQGPYAPQPPPQQAPYGQPPQAAAAPRAPVGPPPSGPPRGMPKMSSGPPPARPAAQQLPTPQQEEPPAVTPQPQVPSTPAQPKYPRGDRSHIPASAQPIVDLLTPEVSRIKAVAPQTFKPQVDDMEKRINILFDHLNNEDLLQPDTVQQMVQIAQLVQQKDFDQAQARFNEMQQTKLETEGTHWMVGVKRLIAIGKATTKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1QN72</accession>
    <name>N1QN72_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">General stress response protein Whi2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_146545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765679.1">
        <property type="nucleotide sequence ID" value="XM_016903719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QN72"/>
    <dbReference type="STRING" id="692275.N1QN72"/>
    <dbReference type="GeneID" id="27900856"/>
    <dbReference type="eggNOG" id="ENOG502R3S1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028899_0_0_1"/>
    <dbReference type="OMA" id="HKLLLFW"/>
    <dbReference type="OrthoDB" id="9451547at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13384">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13384:SF16">
        <property type="entry name" value="GROWTH REGULATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF17558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="33455" checksum="B099539E0856A824" modified="2013-06-26" version="1">MAAAGGAASILTQVQQAGPAPINTSLGGGSEENITLELRGTRFTLSRDELLTLPEFVLLSLFPNGLLPDGHMNSYQDGDVYPVDYDPISLQYMLEFFRNVAQTIPQASEEAQGQSSDPLAPNTMPIEPMSGNARDMLQDRAGIIVLREDLDFYAIPPRKDVEQMEMINIKRAASRALLKQDGIFSGLRKSEEPGTTEQHLIEMLTAGGFNHDDIWGHRAAEPQKAVICSIALARLRTDINKGDTAGVANAVGMAQKLLLFWRKPARRCWWEGVELDDVEGVPGKLKVWIRRVWTLEMSVIGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNJ1</accession>
    <name>N1QNJ1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_146746</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765924.1">
        <property type="nucleotide sequence ID" value="XM_016903835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNJ1"/>
    <dbReference type="GeneID" id="27900972"/>
    <dbReference type="eggNOG" id="ENOG502T00Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1289656_0_0_1"/>
    <dbReference type="OMA" id="RQWEVRK"/>
    <dbReference type="OrthoDB" id="5425637at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110483" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF17803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="214" mass="23049" checksum="C6F804BF9B3F2FE3" modified="2013-06-26" version="1">MKLAHLLPYLACLSFVAAGVNERHANEDSTSVQTSDTVPATISSTTTGDVESRDEDGTNETGFADSNSGTDTEAGASGSQAGSFSLSRGGLVAIIVVVAFVAILGVASTVLFVLAKRRSWNIRQSLKRASRRFTGRATRDATRDRQSKRAGLQMSRIPAQRIHTKRGMAVQVDDVEKGSMNISKGTSKAVPQEASKTQSKSKWSEKLWSNDWQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNU5</accession>
    <name>N1QNU5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Actin-6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_146599</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family. ARP2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765750.1">
        <property type="nucleotide sequence ID" value="XM_016903758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNU5"/>
    <dbReference type="STRING" id="692275.N1QNU5"/>
    <dbReference type="GeneID" id="27900895"/>
    <dbReference type="eggNOG" id="KOG0677">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027965_0_2_1"/>
    <dbReference type="OMA" id="WEDMQHL"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044396">
        <property type="term" value="P:actin cortical patch organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030476">
        <property type="term" value="P:ascospore wall assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051654">
        <property type="term" value="P:establishment of mitochondrion localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd10220">
        <property type="entry name" value="ASKHA_NBD_Arp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000050">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000005">
        <property type="entry name" value="Actin-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF17629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="389" mass="43726" checksum="CEAC1FA7A95DC52D" modified="2013-06-26" version="1">MAEAPIVLDGGTGFLKAGYAGQNFPDHQYPSIVGRPILRTEEQAAGDVQLKDIMCGDEAAAARSMLQITYPMENGIVKRWEDMQHLWDYTFFEKMQIDPTGRKILLTEPPMNPLKNREQMCEVMFERYNFGGVYVAIQAVLALYAQGLSSGVVVDSGDGVTHIVPVYESTVLNHLTRRLDVAGRDVTRNLISLLTRRGYALNRTADFETVRAIKEKLCYVSYDLALDQRLSEDTTVLVESYTLPDGRVIRVGSERFEAPECLFQPHLVDVEQPGIAEFLFNTIQSADVDIRSSLYKAIVLSGGSSMYPGLPSRMEKEIKQLWLTKVLGGNPERLSKFKVRIEDPPRRRHMVFLGGAVLANIMADKDNMWVSKQEWEEQGSAALKKLGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNV0</accession>
    <name>N1QNV0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DHH phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_146616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765775.1">
        <property type="nucleotide sequence ID" value="XM_016903769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNV0"/>
    <dbReference type="STRING" id="692275.N1QNV0"/>
    <dbReference type="GeneID" id="27900906"/>
    <dbReference type="eggNOG" id="ENOG502QQ02">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034130_1_0_1"/>
    <dbReference type="OMA" id="MGTHGDL"/>
    <dbReference type="OrthoDB" id="284473at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1640.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051673">
        <property type="entry name" value="SSDNA_exonuclease_RecJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30255">
        <property type="entry name" value="SINGLE-STRANDED-DNA-SPECIFIC EXONUCLEASE RECJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30255:SF2">
        <property type="entry name" value="SINGLE-STRANDED-DNA-SPECIFIC EXONUCLEASE RECJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="DHH phosphoesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF17654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="488" mass="53237" checksum="5AA1C0E4C261357D" modified="2013-06-26" version="1">MSLARKRTLPSGESNAPAKKRRKPAVVLPQYHESPSVKNEDGSIQWPAPQSQIDHARDIILQSAQSSGRILIVPDKDADGLSAGAILRHTLMLLGVSAERIHVHLLGKGSNVHSELERHGMAASKPDYIFVLDTGSGAGPPLIDGEHVGLVIDHHYATATDFPHAASYVTACDSPPVATSALLTYHICEPLHPDVASTCDWLCVVGTIGDLGNSLKWQPPFPDMSTTLKKYTKKTLSDVVSLVNAPRRTATYDVHSAWEALSSATELSHITTNARLRAARAEVFKEVERCKHAAPQFSGDGKVAVFRIQSAAQIHPMIAARWAGHLQSNKLEIVMVANEGYLDNKVNFSCRIPRCARNRKTPVNIIESLKAYASLPDLKVAAENGDAPKEGPGREAEAEEAEPTLLQRMGEHFARGHVQASGGIVAPEDFEELMRRMEVGVKKKKKKEEEAEEEEEASSSRGSPSKTKKREIDATQKNTLLTYFGKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNW4</accession>
    <name>N1QNW4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UPF0057-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_160929</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0057 (PMP3) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765845.1">
        <property type="nucleotide sequence ID" value="XM_016907915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNW4"/>
    <dbReference type="STRING" id="692275.N1QNW4"/>
    <dbReference type="GeneID" id="27905052"/>
    <dbReference type="eggNOG" id="KOG1773">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107649_6_2_1"/>
    <dbReference type="OMA" id="VHAIWVI"/>
    <dbReference type="OrthoDB" id="2802411at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000612">
        <property type="entry name" value="PMP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659">
        <property type="entry name" value="HYDROPHOBIC PROTEIN RCI2 LOW TEMPERATURE AND SALT RESPONSIVE PROTEIN LTI6 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659:SF42">
        <property type="entry name" value="UPF0057 MEMBRANE PROTEIN ZK632.10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01679">
        <property type="entry name" value="Pmp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01309">
        <property type="entry name" value="UPF0057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF17724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="57" mass="6275" checksum="C2C14E8AE1EFBA48" modified="2013-06-26" version="1">MPFTGSDIIKIIFAIFIPPVGVFLERGCGADLLINILLTILGYIPGIIHALYIILKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNW5</accession>
    <name>N1QNW5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA polymerase epsilon subunit D</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">DNA polymerase II subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_130416</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765850.1">
        <property type="nucleotide sequence ID" value="XM_016902357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNW5"/>
    <dbReference type="STRING" id="692275.N1QNW5"/>
    <dbReference type="GeneID" id="27899494"/>
    <dbReference type="eggNOG" id="KOG0870">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043417_1_1_1"/>
    <dbReference type="OMA" id="NTYRRKV"/>
    <dbReference type="OrthoDB" id="1707486at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008623">
        <property type="term" value="C:CHRAC"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22928">
        <property type="entry name" value="HFD_POLE3_DPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051377">
        <property type="entry name" value="DNA_Pol-Epsilon_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46172">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46172:SF1">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="7">
        <location>
            <begin position="43"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="137"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
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        <location>
            <begin position="210"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF17729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="287" mass="30847" checksum="1AEA749C8F683075" modified="2013-06-26" version="1">MPGRKSNVSTASNGPEEVSEGTPAAATKASSREKEGFSVEDLSLPKSMVARLAKGVLPANTQIHKDALLALHKSATVFVNFIASNSNDNAQAAGKKTIAPQDVMAALKDSEYESFLPRLDAELKKYNEMQCDKRNTYRRKVKADKDAAAEKEPGEGDTSEVAKDGEAPASATNGSAASKSANGNDNNVGRPTKKLKGENGTAVPKADAEMRDDDDDDNDDEDDDNDEDDDEQDAHEQEEDEGEDGAEDEDVADEEESQDEQMVDALEEQDEDASGMRDEALDDPDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M3AV53</accession>
    <name>M3AV53_SPHMS</name>
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        <recommendedName>
            <fullName evidence="3">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_135360</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF09956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016902709.1"/>
    </dbReference>
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    <dbReference type="STRING" id="692275.M3AV53"/>
    <dbReference type="GeneID" id="27899846"/>
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    <dbReference type="OMA" id="CDAEDEC"/>
    <dbReference type="OrthoDB" id="3647953at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004030958" description="Apple domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="255"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF09956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="364" mass="36804" checksum="91C5331CCA4BADE2" modified="2013-05-01" version="1">MAPSTFASLSGALFGMIQLSNSLIITQTVHRSFCPATTTASLPSCGWISASGSTSIPYCFSTSSSQISIASSTRTAPVISITVTPLPSTLNTNILTTTIVSSVTATATATTLSTVYFPPGYNSASSSSSTASTTTTVTSIGDGSAPVYGGASTTTTSITSTATPPGYQGASSSSITTSTLTTSTTNIGAPGYGDLVTTTTTTTTSTSTSPTNALITPSIVPTSLPTYCYQDGALLNAGVNITITDNAGQAYVLLCLNSGLDLLGVGLSGIALATVSAPNSADDCLAVCDAEDECTGFAFQSIAGWGIGPGTCFLYSGIGLSFTNSELLNLIAFIKLDALTGLPLRRRGRRESARRGVMMVDGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M3AVL5</accession>
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    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_49955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016909143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AVL5"/>
    <dbReference type="STRING" id="692275.M3AVL5"/>
    <dbReference type="GeneID" id="27906280"/>
    <dbReference type="eggNOG" id="ENOG502S6PD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038384_0_1_1"/>
    <dbReference type="OMA" id="LYFGMWY"/>
    <dbReference type="OrthoDB" id="4838853at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42024">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42024:SF1">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF10106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="406" mass="45567" checksum="8B293969B47A5F82" modified="2013-05-01" version="1">MVRRRSSGAVNALSPDATRDPTAPDVEALEGYQTAEESRPLYEPQPPPLNYSLWDRRWFIAFFWSMILIDCIAAPIVLYFCLWYLTDLSPNAVFSIVTAALGGVSIFEYFIRFWRLWKKSSTCRVLGARRKYLDWFHWNFTLGWVIIMVELIVGTVPENPPIRLLAMPLTSMMWVFGTELLVVDIMRYFEIPAPVRISSIPKGAQLRPAIYSMIEDVVAVDGSGGTEYREALNRRYEASHVFRSLLRRLGVFWAVGAEGMAVVTTVLVFTIGPDAAYVVGWSAPFVWAGIWTVLTFMYAKHMLKKEQLAWTAELQEKQGAMMMTGLSDRGSEIKAEEEGRPRNEIENGALLPGGRDHALQPIPSAMEIPTLHDTQPDAAPDTSRGRSFDMDAPGATAATEEQATKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2022-12-14" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>M3AVU4</accession>
    <name>M3AVU4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_127854</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758322.1">
        <property type="nucleotide sequence ID" value="XM_016902175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AVU4"/>
    <dbReference type="GeneID" id="27899312"/>
    <dbReference type="HOGENOM" id="CLU_2110507_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF10201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="115" mass="12724" checksum="9A6B3632DBDE022A" modified="2013-05-01" version="1">MSIVDDWPLTQNQCTIPTSVQSSCIAQNPSALDGPIIKHSAFSDITTASPYSLMSVTSHQLHWTSRATTAKFNVLLVFIGTKVVELSVDWRDRTVEFQVGLIKRQPGPRDHTGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M3AVY3</accession>
    <name>M3AVY3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-dehydroshikimate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_110625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758367.1">
        <property type="nucleotide sequence ID" value="XM_016900855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AVY3"/>
    <dbReference type="STRING" id="692275.M3AVY3"/>
    <dbReference type="GeneID" id="27897992"/>
    <dbReference type="eggNOG" id="ENOG502QW0W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035063_0_2_1"/>
    <dbReference type="OMA" id="SNAWRPL"/>
    <dbReference type="OrthoDB" id="5360893at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050312">
        <property type="entry name" value="IolE/XylAMocC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110:SF56">
        <property type="entry name" value="DEHYDRATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08740)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110">
        <property type="entry name" value="HYDROXYPYRUVATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="1">
        <location>
            <begin position="29"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF10246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="346" mass="39556" checksum="42B0C60E283E328B" modified="2013-05-01" version="1">MDSLDSIPTAYASCSIGTNPEKSLPDRLEAISNAAFQAIELSMPDLVSFANEHFKTKDIDDHAFDKLEQAAQALKKILDQNKLTVFMMQPFANYEGWEHGSAEYKDAWERVEGWTKIMKAVDCDMLQVGSSDSPEEKIGKDRQRFVTDLQHLADHLGKKGQRIAYENWCWSTHAPNWEDVWDICRQVDRENFGLCLDTFQSAGGEWGDPTTKSGLIEDGRTPDQVEADWKKSCDKLTKTIPKEKIYLLQISDAYKMEDPMEKKDIDGLRARGRWSHDFRPLPFQGYLPTVDFARAVLQTGFRGWFSYEIFDGGKNGKWENKYELGPFARKAMDTQKKLLQAVVKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M3AWL4</accession>
    <name>M3AWL4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed RNA polymerase III subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_150147</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the RNA polymerase III (Pol III) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the eukaryotic RPC7 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759256.1">
        <property type="nucleotide sequence ID" value="XM_016905986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AWL4"/>
    <dbReference type="STRING" id="692275.M3AWL4"/>
    <dbReference type="GeneID" id="27903123"/>
    <dbReference type="eggNOG" id="ENOG502RZ0V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072641_0_0_1"/>
    <dbReference type="OMA" id="ADPYENT"/>
    <dbReference type="OrthoDB" id="5377312at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024661">
        <property type="entry name" value="RNA_pol_III_Rpc31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15367">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15367:SF2">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11705">
        <property type="entry name" value="RNA_pol_3_Rpc31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000777">
        <property type="entry name" value="RNA_polIII_C31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="176"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="176"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF11135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="250" mass="27491" checksum="B1EE6CC2BDBD5A2F" modified="2013-05-01" version="1">MSRGGRGGLAGGAGRMGGKDLPFTVDADLEDQVLAYHNEMNDEEEWTKTLYPPMNIFHAPPPTAREKRLVSALREYRNAARNGPYFIDSPAAGKRDLAEFNAFEDVATYSNKRAKPTGGLPNLKKLPIVKSLLPRELWDLCDDDDEENGTTEGEAPKKNLNFLKKKRLDKLAQFDDDADDAAAADKDDDDEVNENEDGGEDEVEELRDDDFSEDDDDLGNDYNAEKYFDDGDGADDDGDGGDGGGGEDAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M3B0Q0</accession>
    <name>M3B0Q0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Flavin-binding monooxygenase-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_155682</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761473.1">
        <property type="nucleotide sequence ID" value="XM_016907632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B0Q0"/>
    <dbReference type="GeneID" id="27904769"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015676_3_0_1"/>
    <dbReference type="OMA" id="IWILRTI"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050982">
        <property type="entry name" value="Auxin_biosynth/cation_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539:SF68">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF13352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="595" mass="66617" checksum="6C8483F1B397219C" modified="2013-05-01" version="1">MRTAAAQFDDIPGQLPEAKVPEDADYASIGQATIEKLNNLQDHDLAPFAIWRDLLSLTDTFRTFQSAETVFKNFTHLRAEKHCSDFRLHNESEPRRTDAPDPPTSWLNYDVSFTVNNGGLIGVCAGTVSVMLTSSGDWKIWMLCTWLENYENHGHPDQTDAKSDSEISKSDDTQVYEAAIIGGGQGGLGVAGRLNALGVRNIMFDERPSIGDSWADRYDSLHWHTIKEYGNLPLGRTFDKDDPDLLPRERIASAYKNWSKKHMLNVREHTQIVGAKWDESNRIWSVEGKTPSGTQVWKAKNLVLTIGPGHKTPVSPDWATPEKIKSSGFKGTITHSVHYHNTDGFAGKRGIVVGTANTAHDVAEDMANAKMDVTIVQRNPTFIFPGEWLVQTEAKSYHRDKPTELSDRQDITRPNKIQRELANRNVHHLIKQNPELFDGLEQAGFKVHRYGDLFTHLYVRFGGHYINTGGSNRIINGEIKVQTAAVKGLTPEGLLFEDGTTVSADLIVLATGYNHDFRDDASQILGTHVTDQMDDYWSPDAEGELRGYARFAGHPSLYYGGGECRSARFFSRFIALQIQKESLGYPLQPYLEGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M3B1C3</accession>
    <name>M3B1C3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">GPI mannosyltransferase 2</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_64653</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the PIGV family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761708.1">
        <property type="nucleotide sequence ID" value="XM_016909685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B1C3"/>
    <dbReference type="STRING" id="692275.M3B1C3"/>
    <dbReference type="GeneID" id="27906822"/>
    <dbReference type="eggNOG" id="KOG2647">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029048_0_0_1"/>
    <dbReference type="OMA" id="WITCHAI"/>
    <dbReference type="OrthoDB" id="10252502at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031501">
        <property type="term" value="C:mannosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:GPI mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007315">
        <property type="entry name" value="PIG-V/Gpi18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468:SF2">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04188">
        <property type="entry name" value="Mannosyl_trans2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 12" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF13587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="481" mass="52668" checksum="D74A03A8D9832338" modified="2013-05-01" version="1">MNIAAGSRDEARINATNTSFARLITIFCFWKALLLLVAAASPGPGYDTSTHLLLFSRQIPDTTTVPSWFEYLVLRLTRWDALYFASASARGPIFEQQWAFSPLLAKVTLGLVGVFFSPERRPGIAAYAFAGIAISHISHLLAVLLLFQLAHEILPASHSRKHQIAFTTACLHITSPAGLFLSAPYGESAFAMANFGGLLCYAKAKRSSQSPESNTAVQAVLWTITSGFLLGVATMIRSNGLFNGIIFAWDAIDCLPGVIGMLQQRNWPALFSLMGTLSAGMLIASGYVLPQIVAYIEYCTDGNERPWCSTALPSIYSFVQSYYWNVGFLRYWTLSNLPLFALATPMILVLIGTAYATLDRRQLVHVMDTISISKRPDSDSAQAQSKALFWNTIPRLALPQLILAGLAITTFHVQIVNRISSGYPVWYLILAIAMHPEPGAGEVKGRSVISLCSRYAEWLVRASVMYAIVQGGLYASFMPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M3B235</accession>
    <name>M3B235_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_12410</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761963.1">
        <property type="nucleotide sequence ID" value="XM_016901882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B235"/>
    <dbReference type="STRING" id="692275.M3B235"/>
    <dbReference type="GeneID" id="27899019"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_5_4_1"/>
    <dbReference type="OMA" id="WTENDLD"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF60">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF13842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="94" mass="10134" checksum="FF012AB00D32996A" modified="2013-05-01" version="1" fragment="single">GLFLYGWTAEYEIHWIVPNIGTCIFSIGLIVCFNCAQGYVVDTYTTYAASATGAAAFVRTMAGFSFPLFAPRMYKVLGVGWGNSVLGFVSLTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>M3B295</accession>
    <name>M3B295_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_156059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762008.1">
        <property type="nucleotide sequence ID" value="XM_016907654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B295"/>
    <dbReference type="GeneID" id="27904791"/>
    <dbReference type="HOGENOM" id="CLU_750414_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF13887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="369" mass="42357" checksum="143A2FF22CBF8F95" modified="2013-05-01" version="1">MAMERCTYDFIQSSETTGMASGGHLYLFPSAPSAPSPPTRHPPPSRQNSYRAIPSLAATRGASSGAIYMYSSPLQQYYRLPQAHQPFSLQQLLPEPHYRQFYRERVQFFNHSYLSPRMAHNYHHQRFFAQAPTVQAHPLAVRLQGLLSMSISQISLISATEIHTLRAYRDQSHALYMQWAYTQPNPAERLDQLDDWRYKTDVAFQKWLDCFEANHALQQREVEQSKASADFKGALHLKDMAYEKSSTSEVDAANRPKIENWRNRVTDSNLVDEPSDDEDLQEYRLGAAAQVNRDHVNYLEAAENHGYVIQWAVKPAKKRARTPSEQEENREREASASSVAKRAKASPQGENNEMLEDPLPDRTRKHSRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M3B311</accession>
    <name>M3B311_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GTP-binding protein Obg/CgtA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_8987</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762313.1">
        <property type="nucleotide sequence ID" value="XM_016910512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B311"/>
    <dbReference type="STRING" id="692275.M3B311"/>
    <dbReference type="GeneID" id="27907649"/>
    <dbReference type="eggNOG" id="KOG1489">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011747_2_6_1"/>
    <dbReference type="OMA" id="PRVGHWE"/>
    <dbReference type="OrthoDB" id="347018at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01898">
        <property type="entry name" value="Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.210.12">
        <property type="entry name" value="GTP1/OBG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006169">
        <property type="entry name" value="GTP1_OBG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036726">
        <property type="entry name" value="GTP1_OBG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045086">
        <property type="entry name" value="OBG_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702">
        <property type="entry name" value="DEVELOPMENTALLY REGULATED GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702:SF31">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01018">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82051">
        <property type="entry name" value="Obg GTP-binding protein N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51883">
        <property type="entry name" value="OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Obg" evidence="5">
        <location>
            <begin position="12"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="OBG-type G" evidence="4">
        <location>
            <begin position="256"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="120"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF14192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="519" mass="55879" checksum="9BB76042FDF8C1FE" modified="2013-05-01" version="1" fragment="single">HLDPAPTDYSSAPFTDACTLIVAAGSGGHGCVSFLREKFIAAGPPNGGDGGFGGSVYIQAVQGETSLHKIARRGLLKAGRGKNGQGSLKGGAKGHDVLITVPVGTVVREISRNDPMEAVEAEEARERHRMRNGRGRKAFDEDARAEAKEDVFGDKPGSQRDEWLIYPGGLPKHFTPDDFPPLPRPRRSPLAAAQPRAPLRLDLDKAMEAPMLLAAGAVGGLGNPHFVSKQDLKPKYATKGQEGMRIHLQLELKLLADVGLVGLPNAGKSTLMRAITRSRTRVGNWAFTTLAPNIGTIVLDDHIGRPSLVTKEWRKRPRERLTIADIPGLIEDAHLDKGLGLGFLRHIERAAVLAFVIDLNAGDAVSALKGLWREVGAYEKLREHELNAETERVKSQEDAVVAFEPFSSSISPGLDPEAVREGGDDALVLDPAPGRKLPPLSLPPISSKPWLVVGTKADLPGAQENYMQLRSYLQRVQAGKEEHPSGKQNAWKTNLVSTPVSAINKQGVDSLPGTLLQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M3B827</accession>
    <name>M3B827_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PalH-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_147699</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the palH/RIM21 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764108.1">
        <property type="nucleotide sequence ID" value="XM_016904470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B827"/>
    <dbReference type="STRING" id="692275.M3B827"/>
    <dbReference type="GeneID" id="27901607"/>
    <dbReference type="eggNOG" id="ENOG502QWMT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014594_1_0_1"/>
    <dbReference type="OMA" id="PRQIWAN"/>
    <dbReference type="OrthoDB" id="5393256at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071467">
        <property type="term" value="P:cellular response to pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014844">
        <property type="entry name" value="PalH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35779">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALH/RIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35779:SF1">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALH_RIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08733">
        <property type="entry name" value="PalH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="449"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="511"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="566"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="641"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="668"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="744"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF15987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="774" mass="84201" checksum="7D406A5F2CE48A9A" modified="2013-05-01" version="1">MFQGGAHLEPRQLWDLPTMTTSTDDQAHCTPFTLPSNGVLSLANDAAITLTTDVIFQPECTGTRAGDVFTVDHLRDPFYASTIPMVYVVSAATVIAWILVVMLTITPRTGFFGAPGAPAFSNGRGIIGGANGGVLGVTGTGSRPWLQKVAALAVAISLTIASADTLEVAENQYSMGFSDAALLRKAVLGSLEIRITRVISDIFLWLAQVQTLIRLFPRHREKVLIKWIGFVLILLDTIFSCLNSFYSVNVLNGRNIVDAIPALSYLFELALGLLYAAWVLYYSLTKRRYAFYHSKMRNILLIAIISIVSILTPVVFFITDVANEDVAGWGDYFRWVGAAAASVIVWEWVERIEALERDDKKDGILGREIFDGDEMVDVMPEENVAWTESRNLRRNFRRRRDDDPNGGGNMSTTVERGHGLNGVTQRFRSRHQQSPSHFPLGRAHNESVLTSNDNLRPGNGLAMQQPPHDSSVLGGPTPPPQVASPISRADTTSAASTLYVVRYHPIADVPQPIRRRANADRSGAAGQGDQPRGLQNRELGVKDVADVDDDEIRPNVQRGNNRLWNAVSNPFKRKRTSPPTEVQKARQAAGQRVSTPGKEPPRWDLRNRKGTKAPETGTESRQEAELPVTVIPAQPRGGHRTWSSVDQTPATTPLQLVYRQDPPGSKGTGSTTLTANSQSNRWAPASSQPDGSSVRLPDTGSAVVPSSQMSVGGTGPPRADDISPVNGRNAGTIVVPAPPRRTPSHQTPPLRTGVTPSSSRHTPPNDVQPAPPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M3BP38</accession>
    <name>M3BP38_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_55145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456273">
        <property type="protein sequence ID" value="EMF07923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756044.1">
        <property type="nucleotide sequence ID" value="XM_016909334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BP38"/>
    <dbReference type="GeneID" id="27906471"/>
    <dbReference type="HOGENOM" id="CLU_2948364_0_0_1"/>
    <dbReference type="OrthoDB" id="4364441at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF07923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="61" mass="7186" checksum="7C3F91E9BFD52351" modified="2013-05-01" version="1" fragment="single">QRVKYLIDLTKPFVAAIATIGTTKGPTIYLVLVYYNQLFDILEEAIKRLKNKRIPWKKDIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M3BS62</accession>
    <name>M3BS62_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Dopey_N-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_136257</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DOP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757039.1">
        <property type="nucleotide sequence ID" value="XM_016902764.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.M3BS62"/>
    <dbReference type="GeneID" id="27899901"/>
    <dbReference type="eggNOG" id="KOG3613">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001197_1_0_1"/>
    <dbReference type="OMA" id="GLETCIA"/>
    <dbReference type="OrthoDB" id="297643at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040314">
        <property type="entry name" value="DOP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056457">
        <property type="entry name" value="DOP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007249">
        <property type="entry name" value="DOP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056458">
        <property type="entry name" value="TPR_DOP1_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042">
        <property type="entry name" value="DOPEY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042:SF24">
        <property type="entry name" value="PROTEIN DOPEY-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24598">
        <property type="entry name" value="DOP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04118">
        <property type="entry name" value="Dopey_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24597">
        <property type="entry name" value="TPR_DOP1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DOP1 N-terminal" evidence="8">
        <location>
            <begin position="39"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="DOP1-like middle TPR" evidence="9">
        <location>
            <begin position="389"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="DOP1-like C-terminal" evidence="10">
        <location>
            <begin position="1332"/>
            <end position="1802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1018"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF08918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1827" mass="201162" checksum="10C3722F30C5F20A" modified="2013-05-01" version="1">MSLDIPSGGRSISPSSSGRASPVPRNTRRAVEGDLFRADKSLRRYGANVERALATWEISPEEWADYIAFLARLLKAIQTHPKDVGLLPHSTAVAARLAQCLNPALPSGVHQKALEVYNYIFSTFGGDFISAHLHELLPGLASVLSFASLSVRPGLYDIFEQHVVVLPPDELRPALKSLILGLLPALEEGQGEDFERAFGVLSALEQSFASHHEDAFSSDDSGGYFWQCLFLGVITSPARRQGALNYLLRALPTFPGSVSIVGSGSKPASMSREVECIVSPEPGLLVRCFVCGLSDSQLLVQRGFLDLLVTNLPLNSLVLQERAGNENLDRLVTAVSQVSLRKDMSLNRRLWSWFLGPEPKDIADNSQLSSLNLERNLSNDATTTTQQDYFLKYGRKSLERCLLAMLQTPNQDVATRARAYRVCSSLMDRWEIGGHLVTRIFPPAMRALHAYGLTASASQVADVVKSASTFFDTVEASLIFSTFIDILQDALDRGCSAELNLELVTWVVDTFNVRDEEMVVTHIPTMLVYLASNMVSSAQSPGVQLRIMTLMSRLLDLIPVRTLQPSRQGTVGRSDTPDAGDVADEHIRHTVLGFYQQAGAADHKHPPFSVNHIISLTGSRVASVVGSALVVADSQIYVPSVALLQTLLDKASNIDVLRYSDLCEKLQNVTEQRAWTAQDLSFPMISATVSLIASLHPAKPQSCLDSAVLQELVAGLAAQLWNYLSPEHPKYHVEAVRALWHLEELIAPEDALRSSLTKLTRAPAPDVGQAETFRRFTVLWIHSVPPSGQETTSNRRASSMSVLAGMRHSADAKTILEPSLMLALDALDDITEPAFEVIKSWLHNLTTLDQILQLLFARLKRCSLVQKDSTPGISTAQYKRQQADLVRDLEHVLRHFQGILTHGTQWTWQCLSKTSISTRPEDEHHNALSFLAVTCIELLCNEQHDSLAVNRLLLSMLDAMLLGPAAIELQPLDLDASLLDKLMICINGDMHTLQGGLLKLIKTSLKLRLHITAVPTDVHPPPLSTSTKEKRPSPAPSPRPWASTNGAAAKSVVKHHPPQLFDCIRTGFSSPRARYHLDLWLDFLADILPNFADAIFSNLLPLVGTFCQQLDQTHDQLAAISSTKDLTTVVMPEAVISNLLGALEMILDHAYRCLLSETAEDTAPKDVESRSYFFTNVATGVFKSEGPPSRTATANSRLTVILVLHDAIRVALKMWLWASDTNSTAHDQSSASTTAYNAFKVRNKSRHILEQIFAVEPLESLEVIMLHWCDTQTAHEAASTMSLLQIMQVSKPKRVIPAILDALCTRTNPTSIPTSRHSSLTIDLSSGNVATFLSAYLDSTEDDAMDEVWPNCISFLRDVLSNPLPHRQVLSHLLSIILLLAEKLSNTNFGEQRKMRKDLGDIFQRLLTATFTALPSGSIAEYAVDNMQHGDNGYRQAETEQAMALLPVLNRVTAKIDLILDTPEKIAAAINNISQSLIAPIFRSRTFPKNVSVDVLQLVVEISRKGPAMKTWKKEVTDAFNDPRLFACSPELMADGWFPALHQWSLDDKERMPDLLSRLAPPSSAGIMFGVGASAARLEADRKTQLNLRRMCLLFLASPEDTYMPHLRTIEEKLSELFEASPASSPSATIKAELFMLCRVLALSVSAMHLSPLWPIINDKLQAVLTSLFPSHSTARDYNNLTLLQACKLLDLLITLSPDEFQLHEWLYITDTIDAVYQPLEWSSAALSDQIAEALGSSSMEDSMTATSSLATSAGKRVPLLGADLGVDKGDVKAMAREDFTRAVLRPFLNQLSIHAYEGVYSMDAPDVAALRQDVLNDLLDVSTMVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M3BSC9</accession>
    <name>M3BSC9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS monosaccharide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_144774</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757119.1">
        <property type="nucleotide sequence ID" value="XM_016903081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BSC9"/>
    <dbReference type="GeneID" id="27900218"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_12_1"/>
    <dbReference type="OMA" id="EWCEIRA"/>
    <dbReference type="OrthoDB" id="8120565at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF14">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
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            <end position="132"/>
        </location>
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        </location>
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        </location>
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        </location>
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        </location>
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            <end position="366"/>
        </location>
    </feature>
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        <location>
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            <end position="399"/>
        </location>
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            <end position="436"/>
        </location>
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            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="477"/>
            <end position="497"/>
        </location>
    </feature>
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        <location>
            <begin position="38"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMF08998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="521" mass="57946" checksum="C6111F836C265E27" modified="2013-05-01" version="1">MRTTTTLHTAPSTSPQPRQPYCKPGLRGVLSSRYITLCAIFAAMGGLLFGYDQGVISIILVEPQFLSRFPQISSSSSSSSGFWKGLLTAMIELGALIGAFNQSWIAEKYSRKYSIVVAVVIFTVGSILQTAAQDYVMLVIARLIGGLGIGMLSMVTPLYISEISPPEIRGALLVLEELSIVSGIVVAFWISYGTYYMKETEWAWRLPFVLQILPGLVLGMGILFLPFSPRWLASKGRDEEALANLANLRQLPRSDERVLMEWFEIRAEVALHREILAERHPDLQDRSRRSRVKLEIASWGDLFKKGCLKRTHVGVGIMFFQQFVGINALIYYSPTLFQTMGLTLPLQLLMSGILNITQLLGVLTSLWTMDKLGRRPLLLVGSALMFLSHLIITILVALYSSDWTSHRLQGWASVAMLLFYMLAFGATWGPVPWALPAEVFPTSLRAKGVALSTCSNWGNNFIIGLITPPLIQHTGYGAYIFFAIFCAASFVWTWLFVPETKGKTLEEMDRVFGDEGWTQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M3BSZ4</accession>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">SEPMUDRAFT_127569</name>
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            <taxon>Sphaerulina</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="27899297"/>
    <dbReference type="HOGENOM" id="CLU_984083_0_0_1"/>
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        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="261"/>
            <end position="277"/>
        </location>
    </feature>
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        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF09790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="283" mass="30406" checksum="5C3C6A666A4B70CE" modified="2013-05-01" version="1">MTFLRTPNWVVMKRSKAHTAGQKDKVLVTHDGSRQSQSDGAWDMCTSRDQEASQRALVEVEDRYEAALDATGWSKARLMIFVQREDVGGDCYKACSCDNMSSSSRSRWVFAFLMRAERRCGVDSGVNFSAAFAAAFTVSASATASAVPAPAPDPPSGSPSARSGSAEPAAAAFCRWMRAIVAIGFLSLILRRFFLFFLSPEVAVAVAAVLVVPSGMVVCSISMGSMASSKSSSVDVLSCRALSLRADFTAFRLRAMAWGELYASAASSCFFWCSSVIKSMSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2022-12-14" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>M3BUP2</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <lineage>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23236275"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF11054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="102" mass="11650" checksum="2B5AA3388448B27A" modified="2013-05-01" version="1">MPLAGDTRGRFIIHQTDEIVCPVVFWHARNHRTPYPQARTMGPFKGTIQWAQRMSSPESCCFWRRGDRLHSDAVATASPSQRRPRIDTFNHIGGCMPPPYSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M3BW86</accession>
    <name>M3BW86_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF427-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_127081</name>
    </gene>
    <organism evidence="3 4">
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        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016902121.1"/>
    </dbReference>
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    <dbReference type="STRING" id="692275.M3BW86"/>
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    <dbReference type="eggNOG" id="ENOG502S4XN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103537_0_0_1"/>
    <dbReference type="OMA" id="SFYAGPW"/>
    <dbReference type="OrthoDB" id="18996at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.40">
        <property type="entry name" value="Domain of unknown function (DUF427)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007361">
        <property type="entry name" value="DUF427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038694">
        <property type="entry name" value="DUF427_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43058:SF1">
        <property type="entry name" value="DUF427 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43058">
        <property type="entry name" value="SLR0655 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04248">
        <property type="entry name" value="NTP_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF427" evidence="2">
        <location>
            <begin position="30"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF11579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="164" mass="18726" checksum="565B39A683708DA6" modified="2013-05-01" version="1">MSSTTSTGKMLNPRDFPRPPLCERTPRHLEIKWNGQTIADTKDAYWVLETYHPPTYYLPPSSLKVQLSKNSRSSYCEWKGTASYYDLANPNDAKDVVKSRIWSYDNPTGGFREIKDYLSFYAGPWDCYVDGEKVVPQPGDFYGGWTTSDIDTSHVKGAPGTRHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M3BWT2</accession>
    <name>M3BWT2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_149154</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760622.1">
        <property type="nucleotide sequence ID" value="XM_016905376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BWT2"/>
    <dbReference type="GeneID" id="27902513"/>
    <dbReference type="HOGENOM" id="CLU_1644766_0_0_1"/>
    <dbReference type="OMA" id="IVYMETE"/>
    <dbReference type="OrthoDB" id="3621732at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF12501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="161" mass="18203" checksum="01FF135319798563" modified="2013-05-01" version="1">MSDRAKPRYILPANKSLASTSPSKSLAATLEEVSTSNIKMVNERDFELGSPTAKAVLEHVSPHFKTWIYNVSKPTALTFEEGLEVLRGVAKKFPKYREEVLDLTTDIDEKRGCATVVVHVRISGREQTSVEAIREAKWERDEHGKWWLHSFIGIWGVSMDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M3BX97</accession>
    <name>M3BX97_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Plastidic glucose transporter 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_149295</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760817.1">
        <property type="nucleotide sequence ID" value="XM_016905469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BX97"/>
    <dbReference type="STRING" id="692275.M3BX97"/>
    <dbReference type="GeneID" id="27902606"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_43_5_1"/>
    <dbReference type="OMA" id="TAPLNRW"/>
    <dbReference type="OrthoDB" id="5290825at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000100">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF26">
        <property type="entry name" value="MYO-INOSITOL TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G01560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="417"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="447"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="489"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="528"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="554"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="132"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF12696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="656" mass="74005" checksum="C7B9395C31996CB0" modified="2013-05-01" version="1">MADIRKDEEAASHIEPVKRHSISHASSSSGNHDPSEKANTGPEGVTAAAKLRNPLTGMTEEEVIQDVDAFVDSKGLEKSRDAFRKGALLARVNQRSPETGFLQISALSAEEKGWLQDEVNHRWRQPFMLYFLVVLCAGSAIVQGMDQTAVNGAQQFYFRTFNIGEDEVWRRGLLNGAPYLCSTLIGCWTNVPLNKFFGRRGTIFISCFISFVAGIWMAAADTWYNLLIARFALGFAVGAKSSTTPVYAAESAPKNIRGALTMMWQMWTAFGIMLGFVASVAFQGTDFLGVDTQWRWMLASTSIPPLLVMIQVYLCPESPRWYMEKGKFDKAYDALKRLRSHEIQAARDMYYAYMLLKVEAAEREGKNLWKEFFFVRRNRRAAQSSFFVMFMQQFCGVNVIAYYSTQIFMDGGFTEPQALLVSLGTGIVNWLFAIPAIYTIDTFGRRNLLLTTFPLMAICLFWCGFSFLIPDTPSTDPAAGADGLITGPGKLGSIAASIYLFMVFYSPGMGPVPFTYSAEAFPLYIRDVGMSFATATTWGFNFIISLTWPALRDAFTPTGAFCWYAAWNVFGWVFSYFLLPETKNLTLEELDNVFNVGNREHSKYYTQKLPWYMNKHILRRDVEPFEPLYQFADPEAESERRASMVRRSSVTKSLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>M3C0N2</accession>
    <name>M3C0N2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcriptional adapter 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SEPMUDRAFT_149016</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761992.1">
        <property type="nucleotide sequence ID" value="XM_016905286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C0N2"/>
    <dbReference type="STRING" id="692275.M3C0N2"/>
    <dbReference type="GeneID" id="27902423"/>
    <dbReference type="eggNOG" id="KOG0457">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018273_3_0_1"/>
    <dbReference type="OMA" id="ISPACYI"/>
    <dbReference type="OrthoDB" id="270417at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140671">
        <property type="term" value="C:ADA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071470">
        <property type="term" value="P:cellular response to osmotic stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000183">
        <property type="term" value="P:rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010520">
        <property type="term" value="P:regulation of reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02335">
        <property type="entry name" value="ZZ_ADA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000087">
        <property type="entry name" value="Transcriptional adapter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000115">
        <property type="entry name" value="Transcriptional adapter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transcriptional adapter 2"/>
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        <property type="entry name" value="Homeodomain-like"/>
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        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
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        <property type="entry name" value="ADA2-like_ZZ"/>
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        <property type="entry name" value="Znf_ZZ"/>
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        <property type="entry name" value="Znf_ZZ_sf"/>
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        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 2-ALPHA"/>
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        <property type="entry name" value="TRANSCRIPTIONAL ADAPTOR 2 ADA2 -RELATED"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Myb_DNA-binding"/>
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        <property type="entry name" value="ZZ"/>
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        <property type="entry name" value="Transcriptional_adaptor_2"/>
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        <property type="entry name" value="SANT"/>
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        <property type="entry name" value="ZnF_ZZ"/>
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        <property type="entry name" value="Homeodomain-like"/>
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        <property type="entry name" value="RING/U-box"/>
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        <property type="entry name" value="ZF_ZZ_1"/>
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        <property type="entry name" value="ZF_ZZ_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="22"/>
            <end position="81"/>
        </location>
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            <begin position="83"/>
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        <location>
            <begin position="424"/>
            <end position="515"/>
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            <begin position="138"/>
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            <begin position="140"/>
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        <source>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
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    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50135"/>
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            <dbReference type="PROSITE" id="PS50934"/>
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            <dbReference type="PROSITE" id="PS51293"/>
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        <source>
            <dbReference type="EMBL" id="EMF13871.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="515" mass="58631" checksum="D91BF36DD8185556" modified="2013-05-01" version="1">MGLITKAKGAPKSDGGSSGGGGVKYICNVCSNDITATVRIRCASKSCNDYDLCVPCFSQGKANLHHDPRTHAYQVIEPHSIPIFDEDWGADEELLLLEGAEQYGLGSFADIAEHIGGHREKDEVRDHYIQTYVNSSKFPLPERADPKDTTLSDAVPREEFQKRKKRRIDERNKTKDEQKETASIPAKPTSSVPSCHEVAGFMPGRLEFENEYFNEAEEAVQHMQFSPEEGINPATKQFDPETELKMVVMTIYNDRLTARTDRKKVIFNHRLLEYRKNTAIDKKRTKEQRDLHHKLKPFARIMSHPDFVEFSQDLEKEQNLRQAIAQLQEWRRMRIETLQHGEKYEQEKAQRSTARTFPLQGQFDRLTNGIRPKLTDKDKGIPEVAPAVIDYTTKADLPVRLHSDKDPANVVLSGETPKRIPLQPIPGLAPANWDEEQSPDWQLLQASEQDLCSKLRLHPKAYICIKDAVMREAVKCDGRLKKKNVREISKIDTTKGGRIFEFLVESGWISNAAKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M3C468</accession>
    <name>M3C468_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SEC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_147043</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasmic vesicle</location>
            <location evidence="5">COPI-coated vesicle membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_016904048.1"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OMA" id="EVMCAYI"/>
    <dbReference type="OrthoDB" id="18431at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030663">
        <property type="term" value="C:COPI-coated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1000.11:FF:000003">
        <property type="entry name" value="Brefeldin A-inhibited guanine nucleotide-exchange protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.20:FF:000002">
        <property type="entry name" value="Brefeldin A-inhibited guanine nucleotide-exchange protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
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        <property type="entry name" value="DCB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015403">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HDS"/>
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    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
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    <dbReference type="InterPro" id="IPR046455">
        <property type="entry name" value="Sec7/BIG1-like_C"/>
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    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
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        <property type="entry name" value="Sec7_dom"/>
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        <property type="entry name" value="Sec7_dom_sf"/>
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        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF375">
        <property type="entry name" value="LD29171P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20252">
        <property type="entry name" value="BIG2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DCB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sec7-like_HDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SEC7" evidence="7">
        <location>
            <begin position="784"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="369"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="665"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="755"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1184"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1673"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1717"/>
            <end position="1756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1987"/>
            <end position="2021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="137"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="402"/>
            <end position="412"/>
        </location>
    </feature>
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        <location>
            <begin position="684"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1191"/>
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        </location>
    </feature>
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        <location>
            <begin position="1678"/>
            <end position="1694"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00060451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF15061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="2021" mass="224691" checksum="A32873EC634432E0" modified="2013-05-01" version="1">MAGEDLTAAPEMQPPRRDGDEVEDDGIADTTPSQNNMEKEDEDAEPAYEQVDLNDDAVEHGGTTSPDAEDKDKPQEPEPQAVDNTELQQPGSSTPHHEPNVPSASEHVASPPPATPSAPDTPTSRSVSGATRPRTDSQSTTATTATKSSVRSTRTSMVFVVSALESIAASKDARKRKELGDSAQRALSAIRTAHGDASQIDPEVMFEPLSLASESSTEAVVVSALDCIGKLISYSYFSIAAPSDDVPVDRRRPPLIDRAIDTICDCFQGESTPVNVQMQIIKSLLSAILDEKIVVHGAGLLKSVRQTYNIFLLSKNSANQHIAQGTLMQMVGTVFERVKLRIANKAARAPNGPGLGSLGSPSVYAHSDVSSATAGDETPSVADVQTPDEEKAQPKMTLQTFETRKSFDDARITDSAPTMVTKAKRPRDRPSRTGPGPDIPSITVRDDKQEAVAEDEEEDEIYIKDAFLIFRAMCKLSTKALRVEDAVDVKSQGMRSKLLSLHIIHTVLFNHFVVFTSPHATIRSSSNTDPTAFTQAVKQYLCLSLSRNGASSINKVFEVSAEIFSLMMKHLRSQLKRELEVFLKEIYITILDKRNAPHWQKSYIVQHIFGRIGSDPRTLVEIYLNYDCDRQALDNMYQRMIEHVSKMASQPVTINGLQEQAYADAASKQNSASNDWRERGTMPPSLTTASMSSSHDTDQAYPPEYAMKMQSLECLLDTLRSMVNWSQEARAEASSSTLADTDSRLSLEGQRESMDTRLAGESADVHPATPRLADTPLPEDDPEELEKVKQKKTALNNAVRAFNFKPKKGIKSLIKEGFIASSDPRDIAAFFSGNERIDKKSLGEFLGEGDEDNIKIMHAFVDNMDFSRTRFVDALRRFLQSFRLPGEAQKIDRLMLKFAERYLTGNPAAFANADTAYVLAYSVIMLNTDQHSAQVKKRMTVEDFIKNNRGINDSADLPDEYLQGIFDEIAQNEIVLDTERANAANLGILPQQPSGLVNTLANVGRDLQREAYAQASEEMSNRTELLFKHLLKAQKRAGGGAAAAAKGRYLVASSYRHIGPMFEVTWMSFLTALSGAAQESQNVDTIRLCMEGQKLAIRIACLFDLEDPRQAFVSSLSRSTNLYNLSEMKAKNVEALRALIEIAYTEGNYLKESWRDVLTSVSQLDRFQLISSGVEEGAVPDVLRANGGSDGSQANGQGRRSTQIQRRPSGRNGNHGAYQADIAEDARSADMIRGVDRIFTNTANLSGTAIVDFVKALTQVSWQEIQSSGKSDTPRTYSLQKLVEISGYNMLRVKFEWTSIWKILGQHFIDVGCHNNTHVVFFALNSLRQLSMRFMEIEELPGFQFQKDFLKPFELILSNAQQSQVKDMVLRCLIQMIQARGDMIRSGWRTMFGVFTVAAREPYESIVNLAFDNVTQVYNERFGVVLSQSAFADMIVCLTEFSKNSKFQKKSLQAIETLRSTVPKMLRTPECPLSQKAPGLKDAPQAANIPKQPVRRTQEEQYWFPVLFAFHDVLMTGEDLEVRSRALNYLFDTLTNYGGEFPRDFWDVLWRQLLMPIFMVLRDRKSVNVEAANSEELSVWLSTTLIQALRNMISLFTHFFESLEYMLDRFLELLTLCICQENDTLARIGSNCLQQLILQNVKKFSPGHWEKIVAAFVDLFAKTEAKELFSAATSSTYNRDRDTSNGAHDVPKPTPRDLAMDDAASVMTANTNAFGVNGFDDERANGTERVPATPVPLSSDHDGERSPSPARRKVSLEDFSNTTPTRQAPVVVTAARRRYFNQIITKCVLQLLMIETVSELFNNDAVYASIPSHLLLGLMALLKKSYHFAKRFNEDRKLRANLFREGFMKQPPNLLKQESGSASVYVSILLRMYADTSSERAASRPETEHALIPLCKDIIASYIGLDDETQQRNIVTWRPVVIDVLEGVVAFPDAEFNKHVEEFAPLAVGLMARDMGGELQRVVMGVWQRVCETKLGIEMPEHILHAKEGGPSSPGGSVTRERPGVFGTRRGSRAYSLTSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M3C795</accession>
    <name>M3C795_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Metalloprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_162151</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase M3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF16131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764252.1">
        <property type="nucleotide sequence ID" value="XM_016907983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C795"/>
    <dbReference type="GeneID" id="27905120"/>
    <dbReference type="eggNOG" id="KOG2089">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001805_1_1_1"/>
    <dbReference type="OrthoDB" id="534666at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06455">
        <property type="entry name" value="M3A_TOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.40">
        <property type="entry name" value="Endopeptidase. Chain P, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024080">
        <property type="entry name" value="Neurolysin/TOP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF84">
        <property type="entry name" value="SACCHAROLYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7 10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 7 10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004031788" evidence="8">
        <location>
            <begin position="17"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="9">
        <location>
            <begin position="260"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF16131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="769" mass="85583" checksum="1340A7781089E8FC" modified="2013-05-01" version="1">MARFTLLALLLPSIHAYIPSLPRNVVRADGDKLPSGIPRPPEPPLTYNATAESLNTLMDGLTERETSVVDEIVASVDASNATFDNVLLPYLLWENERIRQARPFGAYGMFSTDEDLQAAAENNTGRISSAIRTTLARQDFFTLVDAVNSQYGNDSSLGLENLRALNGPTVDSTGPGLWTTFKNNGQDLKDDSERKALLDLQDRLQDAVSNFGDTVDNDNTTIFFTAGELDGVDTDVVSRLKPGEGDKLIVPVTDGNFAAVMAKAKNATTRYEMYMAYGSKAPSNVDTLKDIITLRDQIARLLGFPDYATYKTNNQMAKTPEAVDGFLADLAKRLTPASQKIIDYEKELKKKEEGNADHFFAWDAAYYEEKTDEDNSVNFTLISEWFEVNTTVSRVLDIYSVLFGLRFDRIDGEDADQLSSTGKGSDLLLHPDQQLYAVWDSAPSSSSDDSMTGYGDFKGYVCLDLFVRDSKGGGSFQMLVTPSYTRQDGTRAYSHSTMSLDVVKSESEKPSLLTQDQLSGLFHELGHCMHQILSETKYARINGPIATPIDFVETPSQLMEQWAYIPEVLKRVSRHYSYISPTYADIWRKTQGGDMNAQQPEETLPASQIESINNDKNAYSALSALKQVYYATYDMRINEADYVQKQINDLDMTTLFNQLKTNMTLTEGAEAIGKGWTSTHMQSTFTHISTSSYGVGYYGYQYALVNCLDVLYTAFLQDPFSSEAGGRWRRIVLEPGAIKDPEAMLEEFLGHKPSDEAYFKDLNMTTPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M3C7S4</accession>
    <name>M3C7S4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Deoxyribodipyrimidine photo-lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_128969</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="4">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA photolyase class-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF07935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756056.1">
        <property type="nucleotide sequence ID" value="XM_016902246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C7S4"/>
    <dbReference type="STRING" id="692275.M3C7S4"/>
    <dbReference type="GeneID" id="27899383"/>
    <dbReference type="eggNOG" id="KOG0133">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010348_2_1_1"/>
    <dbReference type="OMA" id="ETLIDWD"/>
    <dbReference type="OrthoDB" id="435881at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003904">
        <property type="term" value="F:deoxyribodipyrimidine photo-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043153">
        <property type="term" value="P:entrainment of circadian clock by photoperiod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.579.10">
        <property type="entry name" value="DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="CRYPTOCHROME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455:SF18">
        <property type="entry name" value="SI:CH1073-390K14.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00147">
        <property type="entry name" value="DNAPHOTLYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="Cryptochrome/photolyase FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="Cryptochrome/photolyase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="2 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="6">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="456"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="242"/>
            <end position="246"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="285"/>
            <end position="292"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="383"/>
            <end position="385"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF07935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="475" mass="54595" checksum="91EA3DE34F5C3AB7" modified="2013-05-01" version="1">MQDNKALCAASQKAKEGSGTLLSVYLHSPHDLEWHGTSPSRTDFILESLRLLQEELKGKHVPLAILTAEDRSQKTDRILSFAEEHNVSHVYANFEYEVDELRRDIDCAQKLKDQKVGFELHHDQTVVVPGQLCTGAGGPMKVFTPYHKAWLAETKNDPSLLDLAGEIDSNDESAKKSFAPLFDNTISEPAQKKRFSSSEEKERVRKIWPAGHEAGISRLKHFFDTKVSNYAAHRSEPALDPSSRLSAYISAGIISVREILQYAKEANSNLHFDSGDKGIGSWVRELVFREFYRHMTTITPHGNMNLPQNLKFDFVQWEDDEEGYQKWEQGRTGMPFIDAGMRQLNHEKYMHNRLRMNTSSYLRANLLIDYRRGERYFAETLIDWDLSNNTQGWEPSYTVFNPVVQGEKCDPRGEYIRKWVPELREVKGKDVFDPHARLSQEEFAKLGYPAPHVDFRESSQRAKERYKQDLADADP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M3C7T0</accession>
    <name>M3C7T0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Small oligopeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_94539</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF07940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756061.1">
        <property type="nucleotide sequence ID" value="XM_016910639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C7T0"/>
    <dbReference type="GeneID" id="27907776"/>
    <dbReference type="eggNOG" id="KOG2262">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004965_1_1_1"/>
    <dbReference type="OMA" id="YMVPCGI"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="282"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="430"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="480"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="507"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="662"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="737"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF07940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="803" mass="89772" checksum="71ED90363EE73E72" modified="2013-05-01" version="1">MNRLRRPWTLQRQKTDGIQLNTTEDFGKKPSGSDEENGVELPEKNGAGGNVEPVDMQHGHLQEIEVDLDHVVHDQELKDIDSDTSPYPEVRAVVPETDDTTIPVNTLRMWILGTIWVLIGAGVNQFFSLRYPAVHIVSIVAELLAYPMGVALAKILPIMTVQLPYFGEWRVNPDHHFNIKEHVVIVIMSNVTIGFGGGADATNIIQAAKKFYSFDVSPGFSILVVLCCQVLGFGVAGLCRQWLVEPANIIWPGVLGNCALLNSLHSRANVVANGWKISRIRFFMIVMLCAFCWYWLPGLMFTALSYFTWVCWIAPNNVVVNQLFGFQTGLGLSPITFDWSQIAYNTNPLLSPSWAAINVFAGFAFFYWIVVPGLYYTNVWYTAFLPMMTADVYDRTGADYDVSKVLTASGTLDPVAYAAYSPPYLSATFAFVYGLSFASITAVLVHVYLWHGSDIYAALRGRQKLDIHGRLMRAYRHVPWWWNVVLLCIFTALSIVLVEVYDTKLPVYGVFLALLIPAIYMVPCGIIQGITNVDANQLNVLSEFIGGYMFQGKPLANMVFKILSTDVVSQGIFFAQDQKLGHYFKIAPRTVFWAQGFATILGGLTQTGVTLWMLGNIQDVCSSDQPDSFTCPNGRTVFSSSVIWGLVGPARLYSIGKIYSKLLHFFWIGALIPLATWAAWKYTKQEWLRKINWPLIFVGTYNVPPATGINYSSWAMVNVIFNSYIKSKAFAWWAKYNYILAAALDFGTAFAGIIIFFAVSYPGYSFPDWWGNNVYLNTADGRGEAWKAMPEVGYFGPANGTWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M3C875</accession>
    <name>M3C875_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_152380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF08095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756216.1">
        <property type="nucleotide sequence ID" value="XM_016907413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C875"/>
    <dbReference type="GeneID" id="27904550"/>
    <dbReference type="HOGENOM" id="CLU_1327117_0_0_1"/>
    <dbReference type="OrthoDB" id="3634987at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF08095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="207" mass="23283" checksum="A21BA47E8CB4F86A" modified="2013-05-01" version="1">MDPRDSNHDGNLEEALVLASQIIPEVERLRSHPELFSNELQEHHFLMKAGQLAYRSRELLDLSEQLGNLNPPLHKQRDGAAADSSADPQTKVKTNPWARFAEPSGLKDLPFVKEVQKDLPDMKPVSGCALPPAMVMIAERNKKRQDWYMGTMTNPPADVLALQHNLGDLVKNLHVVPGLEATHQRGIPLQPPMIEEVRLRKFSRARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M3C9G8</accession>
    <name>M3C9G8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_152112</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756581.1">
        <property type="nucleotide sequence ID" value="XM_016907250.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.M3C9G8"/>
    <dbReference type="GeneID" id="27904387"/>
    <dbReference type="eggNOG" id="KOG0585">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004329_1_1_1"/>
    <dbReference type="OMA" id="HRVRETH"/>
    <dbReference type="OrthoDB" id="68483at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001558">
        <property type="term" value="P:regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Serine/threonine-protein kinase Ssp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895">
        <property type="entry name" value="CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895:SF152">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE TOS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="274"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="67"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="513"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="841"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
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            <begin position="895"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1065"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="521"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="861"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="896"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="935"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="951"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
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            <begin position="975"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
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            <begin position="986"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="997"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1074"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1105"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1138"/>
            <end position="1156"/>
        </location>
    </feature>
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            <begin position="1157"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
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            <begin position="1195"/>
            <end position="1208"/>
        </location>
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            <begin position="1226"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
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            <begin position="1295"/>
            <end position="1312"/>
        </location>
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            <begin position="1334"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
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            <begin position="1358"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMF08460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1385" mass="150656" checksum="673B96301C62B681" modified="2013-05-01" version="1">MSTDSLERNSGENGFLVVLPSGQDGGSGDVDDTPRSEAPPPLLDVTTPRTTEAAVAKSIDYFSQSSAVAAGNQPPHGDSAEVAVGDCTATNAQEANKAQGHTHPPPGSVSTPDALLSPRPAAQHTPSSQSIDSVESVDSVATLKAARPILQPSGSSFPDQSFAALHSQYHGTYYRPSHMRKPLPPVPYSPVANFATAIASHHPRAGQSAPGSPAGGPNYGLFSPSSMTAVRSDTSSATYPSPFLHHTQRHVPKETHIADVDVDPISGRKVINHYEIMDELGRGTHGKVKLGRDLHHDNVYVAIKIVERFSKRRKLGRLGTTEDKVKKEVAILKKARHPNVVALLEVIDDPSRKKVYIVLEWVEKGEINWRRKAPREIAMVEARRYERESREAKTGKHDERLAAQDRAVLEEAKKRLDKQKRRQIRTYRRMRRGVDEAPEVWSNEMAGEDDMSEESEEDRLSRISSITGEMSVPLAQQATQWLDIGAENPSPTTEPLNIPRNVDFNLTGLEGTMYGAYDPNSDPNSTESSLPSSLQGSQHGSVEGLSELAHEVLDSHLDSELEYVPIMSMNEIRGAFRDTVLGLQYLHYQGIIHRDIKPPNLLATHDNHVKISDFGVSYLGRPIHNGEGEDVSETEALDLDDEAKELAKTVGTPAFYAPELCTIDPTDEPLPVTNAIDIWALGITLFCMLFARTPFVESEYVVMRSIAEEEVYIPAQRLLPVDSRPKSRPSSHGRGISPQWARKRNELEFVYEDLGDDLLDLLHKLLIKDPRKRITLEEIRHHPWVLADIPNPLRWFDESDPRHHQEHQKIEISNEELKAAVVPLNLVERAKSVVKSMLGKGRDLVMPGGTGRARGKSNAGSPATSAHSSSSTISQDARRSSIFGSEELFVTALRTSHGDSHGEHPLSKSVAASPEQEHPEKLAPRLNGTSDSSGRRKRMIHRPSPPHRAMTITSNTPSMRTVTQSDYQRGVVSRSPPPPPSPGLPGTPQEVASPGGSSLGGLLGGPGRIIDRVRARSRQRSFDTRGLSSERGSETGSVQSSDPHGEASVAISSATATGLVQQPDLLRGDFTPQSSAHNSPASSRSHSAASDYQYLQPTPGPLSRLGSNSSLTSTGRLEAYRKSPVSRPRQLNESTPEDWERAKVEQVRRRVNEHLQRQQAEMANAASSGTCGSPASTSNGTCPPSPDDHVKVRQESQVPSLTGASTPATPDEVLSPSGTADHLPPALASSSSDFGSAVSMSISNPSIPSAISEASSVDFGEADTNVGRKESSDDTLNSSGQYRHSDEHYDAGYSPDEEATINSDDDDFDSSSDSDGGLVMSRRRSAARAVPTSKARRGTGHSIRSKKSSRSGSSNTVRTRESMKKVRTRESSDEQTRVSLDIHEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2022-12-14" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>M3C9X7</accession>
    <name>M3C9X7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_152265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EMF08660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016907342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C9X7"/>
    <dbReference type="GeneID" id="27904479"/>
    <dbReference type="HOGENOM" id="CLU_1769270_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF08660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="147" mass="15915" checksum="2313A8991BCC7A17" modified="2013-05-01" version="1">MLEELVEIETVFELATLEDLDVPDIIGKVILGGIVEDTIEAVPENTEELLPPPEVVLSVESEALDKEGSKLLEEVLRASVLLAVERPEELKERDWLEDDEDKSVLLGADIGIVVLAEEAVVRSDGIVELGDTRVGSAVNVDGSKDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M3CBJ7</accession>
    <name>M3CBJ7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Allergen</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_150939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF09802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016906486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CBJ7"/>
    <dbReference type="STRING" id="692275.M3CBJ7"/>
    <dbReference type="GeneID" id="27903623"/>
    <dbReference type="eggNOG" id="ENOG502S2AG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047590_1_0_1"/>
    <dbReference type="OMA" id="EGCPTFD"/>
    <dbReference type="OrthoDB" id="2118965at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38703:SF1">
        <property type="entry name" value="ALLERGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38703">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="36487" checksum="CB70335FB1EE6914" modified="2013-05-01" version="1">MDAAKNAVKSFISKDGKHDTTVHEKVNPAVVNETVAKQQEDRVTTAVDKEVHQDHYHTSVQPVKDSNILPEKHHHNLAGVEHRNFEHDNPDQVKQKLAAEQARFKDTTETVAGEHRTTAMPTVAGEHVHHHVHENIQPVVNRQTVEPHVVHTTVPIHEVHHNAAQHHSTSALPAMSMSEFKNSGGSLTGREERHDQFDGCPRPGHASTAGTNNSIEGGAHNHGHSHTHGTTGTTGTTGMTGTNGMTGSNGVTGSNGMTGTSGMTGTTSDGLTGSRAAGTSAGSGATAGGLTGQRQHDVENNLSGTNNSTHGNTSSSNTGSNATKPSLMDKLNPKVDANGDGKAGFMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M3CCA9</accession>
    <name>M3CCA9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_151079</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758133.1">
        <property type="nucleotide sequence ID" value="XM_016906584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CCA9"/>
    <dbReference type="GeneID" id="27903721"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_22_1_1"/>
    <dbReference type="OMA" id="WCILAFG"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000489">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000012">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF199">
        <property type="entry name" value="MFS EFFLUX TRANSPORTER INPD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="105"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="439"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="469"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="504"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="570"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="108"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF10012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="607" mass="64730" checksum="FF9E851721FA9D43" modified="2013-05-01" version="1">MQFFKRQKATSADVPPSTSHSTQPSIHKDDDSEKRAADTLDKSGTHLAVTSPSPTRQLSTDSTDSSGHPQVPANEATLEKRIEGIEADVDEPAADGTVYPKGMKLAAITAALMLSVFCMALDNTIISTAIPKITDQFKAIDDVGWYGSSYLLTTCAFQLFFGKLYTFFSIKWVYMVALIIFEIGSAVCGAAPDSMSLIVGRAVAGVGSAGIFSGAILIVANTVPLSKRPMYTGLIGAMYGLASVAGPLMGGAFTDHVSWRWCFYINLPIGAVTLIFIFFFYHPTTRAKSLAAGGWKAKLEQFDMYGTIIFLPMIVCLLLALQWGGSKYSWSDGRIIGLFVVFGVLALVWGGIQYWKQDNATVPPRLITQRTVASAAWFGATLGASFFIFVYYLPIWFQAIKGVSATQSGIRNIPMILGLVIVSVIAGAIITVLGYYTPFVIGSSVLMAIGAGMLSTLTPSSGSPEWIGYQVLFGAGVGMGMQQTLIAVQAVLPAPDIPIGTATVMFSQTLGGALFISVAQNVFQNKLLTNLRTLVPGLDPAIVQNTGATELASIIPAEFQDGVKLAYNGAIMSCFYVAVACAGLSILGSMFFEWKSVKGKKLEMAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M3CCJ0</accession>
    <name>M3CCJ0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_165799</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758238.1">
        <property type="nucleotide sequence ID" value="XM_016908188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CCJ0"/>
    <dbReference type="STRING" id="692275.M3CCJ0"/>
    <dbReference type="GeneID" id="27905325"/>
    <dbReference type="eggNOG" id="ENOG502RKCT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042941_6_0_1"/>
    <dbReference type="OMA" id="CADWEGM"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF14">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF10117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="251" mass="28588" checksum="99107B5C2A4038E2" modified="2013-05-01" version="1">MAVLFPLNASYQYGVLLNRQILAINSASALTSTHDLVLNATTWSSNPSLWRADPSVEGDKLWSQNWDTHPILIPMKDMPKLGQDPSYVAPWLDDPSLAMVGSQAHHLLHCLDVLRKAVWTDHYWPNGNLNPGHRNHQTHCVDLLRQDLMCRAPMDVYPLIWMDGESQPTPNFNVTSQCADWEGMTQWWREKQMTDEQVDRIWVKPEGVKQWPAPGGLEEEKEALRDVCARPNVTCTLGGEPLIFPDDDENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M3CE14</accession>
    <name>M3CE14_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_150250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759397.1">
        <property type="nucleotide sequence ID" value="XM_016906047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CE14"/>
    <dbReference type="GeneID" id="27903184"/>
    <dbReference type="eggNOG" id="ENOG502SPB4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045435_2_1_1"/>
    <dbReference type="OMA" id="RSNTWIL"/>
    <dbReference type="OrthoDB" id="5332316at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF11276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="409" mass="45905" checksum="F4BB0B6B07791A49" modified="2013-05-01" version="1">MLSARRVSLRIAFPPCCAKATRARRLLSDDGRKVSLIEQLFPEETKRYEEQQKATREIPRLPLGPLPPKSVKETEQLSLRPNRADGEARLHASERARRSQIEVDQPGTAVLVLRNASKNLTVEDFRRLIPQGRHIEGWTLQEGDILQVVPGRDLSTLEHLNYYFILFSTGLGADTYRTHATRIHKLAAIHTPTSNTSPIPPPPGYMIEGLDAHAAIEAYALVPPRQKLELRLLRPPFTPVVQSIIDHGGYKSLVSRKDKMPFEARLTMEGPQLQVNALRHLMLQTGKLRNLTWSGGDKYHVQITSWGPRASPGALSDSAWARRNADGAVDDSAHESSRSRRRESSETMGEKQQLRRTPGNVFIVGFHTEDAAQSFVAYWHKRPLHNSATATVPDVEGDLPPIAHVEMLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>M3CEA3</accession>
    <name>M3CEA3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">L-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="15">1.1.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">SEPMUDRAFT_88887</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(S)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:19909"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19910"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">In the C-terminal section; belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the N-terminal section; belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.3" evidence="15"/>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759497.1">
        <property type="nucleotide sequence ID" value="XM_016910488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CEA3"/>
    <dbReference type="STRING" id="692275.M3CEA3"/>
    <dbReference type="GeneID" id="27907625"/>
    <dbReference type="eggNOG" id="KOG0537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0538">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020639_1_1_1"/>
    <dbReference type="OMA" id="RIWFRPK"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004460">
        <property type="term" value="F:L-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006089">
        <property type="term" value="P:lactate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02922">
        <property type="entry name" value="FCB2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000062">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000012">
        <property type="entry name" value="Mitochondrial cytochrome b2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037458">
        <property type="entry name" value="L-MDH/L-LDH_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF148">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE (CYTOCHROME)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="18">
        <location>
            <begin position="10"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="19">
        <location>
            <begin position="113"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="290"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00061137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00066458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00068515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EMF11376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="506" mass="56570" checksum="B538BA1759241F99" modified="2013-05-01" version="1">MNRDSNDTQSVKLSGEEIAKHNSRESCWVIVHGKAYDVTEFLPEHPGGPKIILKYAGKDATEEYEPIHPPDTLDKFLDKSKHLGEVDMSTVEKEEKEDDPEEIERQERIKHMPILEQCYNLMDFEAVARRVMKKTAWAYYSSGADDEITMRENHSAFHKIWFRPRILQNVESIDLSTTMLGTKVSIPFYVTATALGKLGNPEGEVVLTRGAHKHNVIQMIPTLASCSFDEIVDAKRDNQVQWLQLYVNKDREITKRIIQHAEKRGCKGLFITVDAPQLGRREKDMRSKFSDTGSNVQATGGDNVDRSQGAARAISSFIDPSLSWEDIPWFLEVTKMPIILKGVQRVEDVIRAISVGVHGVVLSNHGGRQLDFARSGVEVLAEVMPELRRLGLENKIEIYIDGGIRRATDIIKALCLGAKGVGIGRPFLFAMSAYGLPGVDRAMQLLKDEMEMNMRLIGATTVDELTPDMIDTRGLSMHTASVPGDTLSLSAYDHLVGPVWKSGAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M3CGR0</accession>
    <name>M3CGR0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pleckstrin homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_86523</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761114.1">
        <property type="nucleotide sequence ID" value="XM_016910416.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.M3CGR0"/>
    <dbReference type="GeneID" id="27907553"/>
    <dbReference type="eggNOG" id="ENOG502QSQ0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006265_0_0_1"/>
    <dbReference type="OMA" id="EWMYKYV"/>
    <dbReference type="OrthoDB" id="2149224at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032065">
        <property type="term" value="P:maintenance of protein location in cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053005">
        <property type="entry name" value="Nuclear_Pos-Cytoskel_Interact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024774">
        <property type="entry name" value="PH_dom-Mcp5-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28190:SF2">
        <property type="entry name" value="MIGRATION PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G07730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28190">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12814">
        <property type="entry name" value="Mcp5_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pleckstrin homology" evidence="2">
        <location>
            <begin position="976"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="513"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="610"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1170"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1223"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="287"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="610"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="677"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="690"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="763"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="783"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="810"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="853"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="865"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="902"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1170"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1226"/>
            <end position="1267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF12993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1350" mass="148246" checksum="2F6FA0DE91A221BF" modified="2013-05-01" version="1">MADYFSEYSSFIGAKGLPSPADTPYETPGFIRSKRSSHATAGSSREQSSSPPPLPLDAVEAQDKARDGRYSGMDRMDPRRFTPTLHASLVSEILNLRRELDSKNTLVEDLESTVSATNGENDILRRQLAESTRDVRKAKQQVQQMEQGTYDAVEDLVRERDTARALLDDARSKLESTQKKTRQQDEDAQRTQNIWETDKEAWDSERRQLERRIHVTETRLRAVVDEMTMQQSSAPMFSLPDDSTFKDSGIGNESDSASIYSATPSVSPTKHRRNMSSSSYNARRTRASVSSRTTAATPDVYSRPGNTLADELDIDELDEYDNEGSVNGEDTDDHSSHFKHASIVRQNSVMGELDAKSRRILSLTTDSSETPAAKDLPKLLADLQDLQEPTKRMYRDRATTPPPTAFGMPEPALRATYVDSGYQPSPPVSPPRVHVTQAVDDTAATGNTTSGDEMRQQSPAAINISATLQQPPQAPQTKPISPPQTPVVDDVTWVHHKAQLTVVLEYSTASTQTELVEPERPKVGDTKKRDSLSPPLFVPSITIHPPNNRPSSPVPYALPPGTKNAFSQASLAWPSQDASMQTEEIRVDKRAVKLPAHLLPSALLPSPTFQEATRPLSQSKRISASSVLTKRASVTRPPAISIPVSPPLQSPVDSSPEMSRNGGARDLRHYPLKALPLPRPVLSPPLPPNETFTSNGPLNRASQYGVSQPRVDYMGGYEPESSESDYDDPVQNNEPMTDLIGMMPAPSRPPLGRFGLSDPPKAVPEDKEISPERRPGTADSYGAAPAPSISSSRATSRRRPTTQQPSTRSGKSPISPSFRSSLASSGHSTHQNEPMPPFPIPFRSSSRPKPHSEGSQSPTTHDSFGPRAGRAGRSAHARQVSLRKVQSAAVIRNRGARGSPTKGHRSPTKGHRRRRQSPQLTPVQSMAVESPEPTKFPIPELPSPVRNSLSFNYVKGSVDLRSTTGSSTRVSEERSLVDAIAGTMVGEWMWKYIRKRKSFGIGDDSSERPVTAENGTVNVTAHGTRHKRWVWLSPYERTIMWDTKQPTSGPALLGKKGRKLAIQSVLDVQDPTPLSRNPELATAWGRSILILTPERALKFTATTEERHSLWMTALTFLAREAQLPNMIPQMPSHRPPPIPPMPPAYLDGVPIKRQRSPSFSRTNVRDSIRLTKVKRAELHRGSSHPDQPFSTADLHDGAVAGAEAESADFPAVPRLYICTSRHQRNRSNTNPGFRSFSSTGIPSSASSVMHSKSNNASSFRPSISTKSGSRRESLASPTHQNFFEAVGTVRMEAFVDPNVRDGVLYVPAPPPVIGGARRPRRSSNLSQSTFDKRRAGYVFDDDGMDPFGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M3CJG5</accession>
    <name>M3CJG5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_149053</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762049.1">
        <property type="nucleotide sequence ID" value="XM_016905310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CJG5"/>
    <dbReference type="STRING" id="692275.M3CJG5"/>
    <dbReference type="GeneID" id="27902447"/>
    <dbReference type="eggNOG" id="KOG3662">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011607_2_0_1"/>
    <dbReference type="OMA" id="TIQNHLC"/>
    <dbReference type="OrthoDB" id="5977743at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033308">
        <property type="entry name" value="PGAP5/Cdc1/Ted1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315">
        <property type="entry name" value="METALLO PHOSPHOESTERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315:SF4">
        <property type="entry name" value="METALLOPHOSPHOESTERASE, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="568"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="772"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="616"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="730"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="652"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="669"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF13928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="798" mass="90056" checksum="11B1624237A5D537" modified="2013-05-01" version="1">MRLRHVAQSSLVRIHRRYPWTRHITTTTLLLAAFWLFLIHSKERTLSRSHIQSCDWKQWEEWHSDATPHRSVFIADPQLVDPHTYPGRPWPLSSLTEYYTDLYMRRHFKLINEVLDPDSIVFMGDLLDGGREWSTQKAKALNSKQREVLINLLILDRDRREGQRLLGDGTTDLNRFVPGENGRWNKWKQGQWDIEYDRFARIFLDEKQLYPNANRTFEPTWELPESPVSIMNGARNITWREYATGGTKSRVVKMNLPGNHDIGIGSGVQVTVRDRFETRFGEANSVYVLGNHTFVSLDTPSLSAYDEYVPDVGEVSEERRTQYSHIWTPTNDFLNGLDKSGPKAVADELEMMFPGSHPRKLWPHDAIEHKDDRGIGEKLKPAAGQLMKRGDDQWQLVSSPTPKKPTGPQLPVVLLSHVPLYRNPDVDCGKLRERGRSIPLAAGYQYQNVLTPSLTKIIAKKVSTAGDIAHIFSGDDHDYCDVTHRFNVGRYDVDTKKERAVMQTVREVTIKSFSWAMGVRKPGFLLVSMWNPVDEKGKHIGECMSGMDSGCKTIQTELCLLPDQLSVFISYAQFLGLTTLVLLVRAVVIGIRNLPDTADEDENELHVDLNAVREKMGLPRYTPRGKPGGRTGSISPRKPSPKRDEKFGGRGRASSTSTGSANASSTSNQHLSVQRSYNARTRTVSPAAAGSLTPNHSGYVLPNLHEANGRINGGAGLIEKAGYYPAMRWRDPDEDEESDEESHMGSQYGDFDSQAKGGKLGKRRPKSRARRALDEFVMSVVLVAIPAALWYGFLIRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M3CJK1</accession>
    <name>M3CJK1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Altered inheritance of mitochondria protein 24, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_131741</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM24 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF13978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762099.1">
        <property type="nucleotide sequence ID" value="XM_016902447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CJK1"/>
    <dbReference type="STRING" id="692275.M3CJK1"/>
    <dbReference type="GeneID" id="27899584"/>
    <dbReference type="eggNOG" id="ENOG502R2TQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040551_1_1_1"/>
    <dbReference type="OMA" id="AMIAMSH"/>
    <dbReference type="OrthoDB" id="1705416at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="entry name" value="Mitochondrial biogenesis AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00266">
        <property type="entry name" value="TIGR00266 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43657:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 24, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43657">
        <property type="entry name" value="TRYPTOPHAN RNA-BINDING ATTENUATOR PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="TRAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF13978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="358" mass="37856" checksum="4F9E280309552BF3" modified="2013-05-01" version="1">MASTQEYFPPPPGGHAHTDNHYPAPPQPQQQQQQHFAPPPTFAPPPTVSPITPPGTEATGIPRATPEPNQQDQISIPYHPGPPTTSQEPEPSYATSNYTALASPRQLSFNRQSSIPGGAPPPGQFTGAGATLDDVGTFNGGSYRISHRDTNTIVTIQLAMGCPITVKPGAMIAMSPTITVKGSVKFSMKKLLARGEMSHTTFTGPGELLLAPFALGDITNIRLSGKGETWNIGKDAFLACTQGVTKDYVSQALSKAIFSGEGLFVYKLGGAGICWIQSMGAIIRKDLREGEKYIIDNGHLVAWNCNYVLERVASGGIISNMSAGEGLVCKFSGPGTVFMQTRNPAAFSQYMAAHGGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M3CNC9</accession>
    <name>M3CNC9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome c oxidase polypeptide V</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_147209</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome c oxidase IV family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763414.1">
        <property type="nucleotide sequence ID" value="XM_016904150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CNC9"/>
    <dbReference type="STRING" id="692275.M3CNC9"/>
    <dbReference type="GeneID" id="27901287"/>
    <dbReference type="eggNOG" id="KOG4075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070101_2_0_1"/>
    <dbReference type="OMA" id="YVIHLFA"/>
    <dbReference type="OrthoDB" id="186013at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00922">
        <property type="entry name" value="Cyt_c_Oxidase_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.442.10:FF:000002">
        <property type="entry name" value="Cytochrome c oxidase subunit V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.442.10">
        <property type="entry name" value="Cytochrome c oxidase subunit IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004203">
        <property type="entry name" value="Cyt_c_oxidase_su4_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036639">
        <property type="entry name" value="Cyt_c_oxidase_su4_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10707:SF10">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10707">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02936">
        <property type="entry name" value="COX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81406">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00081365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF15293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="172" mass="19381" checksum="43205F6D40762237" modified="2013-05-01" version="1">MLRTTPLLRQSLTSLSSARNHTLQQVRCAHAISNPTLANIEKRWEAMPPQEQADLWMALRDRMKVDWNELTVQEKKAAYWIAFGPHGPRAQTPPGENTKVFAYTVVGVLAAAAIFGFSRHFARGKPSTLNKEWQEASNEYFKENKIEPITFIGGEDYKGKGLVQSPPKGKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M3CP67</accession>
    <name>M3CP67_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_38545</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CENP-X/MHF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763694.1">
        <property type="nucleotide sequence ID" value="XM_016908709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CP67"/>
    <dbReference type="STRING" id="692275.M3CP67"/>
    <dbReference type="GeneID" id="27905846"/>
    <dbReference type="eggNOG" id="ENOG502S98G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071333_3_0_1"/>
    <dbReference type="OMA" id="TQSDVGW"/>
    <dbReference type="OrthoDB" id="2500381at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018552">
        <property type="entry name" value="CENP-X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09415">
        <property type="entry name" value="CENP-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="50"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF15573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="99" mass="11572" checksum="E2AA2526AACF911C" modified="2013-05-01" version="1" fragment="single">PSIPQPLLLRLLHEGFHHKDTKIDTRALGMVQQYVEIFVREMIARCVAEKKERKKRNEKEKGEVNEGMRMDDDDDDDDDVGWLDLEDLEKVGVGMMLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>M3CX07</accession>
    <name>M3CX07_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_152462</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF08211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756332.1">
        <property type="nucleotide sequence ID" value="XM_016907458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CX07"/>
    <dbReference type="GeneID" id="27904595"/>
    <dbReference type="HOGENOM" id="CLU_1563854_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF08211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="171" mass="19013" checksum="515C216BC3E250B8" modified="2013-05-01" version="1">MFLASNTFQLETPSRPASVCTPPNLDEGVRLRAFLHHLDRAGLPPPASLVIRIRRSYSGVSVRDSPLPYGREMPQQLREVIVLTAHAGIPNVVCRLETSFGFSAVRTADISMGDFRRSARSEIERLEQESKSDHFPRTPCGMAMLYMWTTLSHIENMPGVQIPPRAPAKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M3CY44</accession>
    <name>M3CY44_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trimethylguanosine synthase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cap-specific guanine-N(2) methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_93325</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78479"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="Rhea" id="RHEA-COMP:19089"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:78480"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78507"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="Rhea" id="RHEA-COMP:19090"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:78508"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78471"/>
            <dbReference type="Rhea" id="RHEA-COMP:19085"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:78472"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78475"/>
            <dbReference type="Rhea" id="RHEA-COMP:19086"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:78476"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757098.1">
        <property type="nucleotide sequence ID" value="XM_016910610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CY44"/>
    <dbReference type="STRING" id="692275.M3CY44"/>
    <dbReference type="GeneID" id="27907747"/>
    <dbReference type="eggNOG" id="KOG2730">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029658_0_1_1"/>
    <dbReference type="OMA" id="KALCIYY"/>
    <dbReference type="OrthoDB" id="10051395at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015030">
        <property type="term" value="C:Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071164">
        <property type="term" value="F:RNA cap trimethylguanosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000270">
        <property type="entry name" value="RNA methylase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019012">
        <property type="entry name" value="RNA_cap_Gua-N2-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741">
        <property type="entry name" value="S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741:SF32">
        <property type="entry name" value="TRIMETHYLGUANOSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09445">
        <property type="entry name" value="Methyltransf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF08977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="235" mass="26224" checksum="5911AA5B2AA19F1F" modified="2013-05-01" version="1">MSPVTEPPEGVHAYTSLDEVPSDLQKYWMQRNDIFSRYDQGIWLTHDAWFGVTPEPIAKKIAEHVATAPKEKKVLIDAFAGAGGNVIAFALSGRWSQIFAVEKDAKTLACAKHNADVYGVARKIFWIQGDIFEVLKGRLKAAAKNAVIFASPPWGGPSYTDWDVFDLSCMEPYNMKVLYDAFSVSSEVVLYLPRTSDVHQLAKYAKQDEKLPVMHYCMKGASKALCVFYGSFQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M3D0N3</accession>
    <name>M3D0N3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF3500 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_126680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759194.1">
        <property type="nucleotide sequence ID" value="XM_016902094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D0N3"/>
    <dbReference type="STRING" id="692275.M3D0N3"/>
    <dbReference type="GeneID" id="27899231"/>
    <dbReference type="eggNOG" id="ENOG502R8TZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033093_2_1_1"/>
    <dbReference type="OMA" id="PAKYHTH"/>
    <dbReference type="OrthoDB" id="4539697at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021889">
        <property type="entry name" value="DUF3500"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37489">
        <property type="entry name" value="DUF3500 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37489:SF1">
        <property type="entry name" value="DUF3500 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12006">
        <property type="entry name" value="DUF3500"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF11073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="432" mass="49959" checksum="B44299C758D85596" modified="2013-05-01" version="1">MTTNGTNNAQVDEELASAFRQHLPDLTSPRFVKTAQQSPYEYSEAFQQKQHPPWLYRLTKAWEDLLEDPFQGVTIDGTVRQGVYKKEDFQGASIDKIVQATNTALGQLNSEQSKKVRYPLNAKQWRCWSNPEFLLRPFGLRLEELPEETAQSILGVLEATFSKQGYQKALAAIRINHFLGEVCKVPRIMNQYSYNFLLFGEPSTDKPWGWSLYGHHLCLNVYLHGSQIVISPYFTGAEPNLIDEGPWKGTQILHTQGDLGLRLMQSLPKEKQQIVQTYKLMRDPKMLQSGDLKVDRWNQDDQRHLCGAFRDNRVVPYEGVKVSEMTAEQQDIVLEIADEFLLYYPDETRQKQKQQIKKHFEETYFSWIGGYGDHDAFYYRIQSPVIVLEFDHHSGVFLANTEPAKFHTHTICRMPNAGDYGQALRDEQDRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M3D0U8</accession>
    <name>M3D0U8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Putative bifunctional AICARFT/IMPCHase bienzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SEPMUDRAFT_71214</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis. Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR). Also catalyzes the cyclization of FAICAR to IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(6R)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + (6S)-5,6,7,8-tetrahydrofolate</text>
            <dbReference type="Rhea" id="RHEA:22192"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="2.1.2.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:18445"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="EC" id="3.5.4.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PurH family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758234.1">
        <property type="nucleotide sequence ID" value="XM_016909933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D0U8"/>
    <dbReference type="STRING" id="692275.M3D0U8"/>
    <dbReference type="GeneID" id="27907070"/>
    <dbReference type="eggNOG" id="KOG2555">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016316_3_2_1"/>
    <dbReference type="OMA" id="IKHNNPC"/>
    <dbReference type="OrthoDB" id="6017153at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004643">
        <property type="term" value="F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01421">
        <property type="entry name" value="IMPCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.20:FF:000003">
        <property type="entry name" value="Bifunctional purine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1380:FF:000003">
        <property type="entry name" value="Bifunctional purine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.440:FF:000001">
        <property type="entry name" value="Bifunctional purine biosynthesis protein PURH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00139">
        <property type="entry name" value="PurH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024051">
        <property type="entry name" value="AICAR_Tfase_dup_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024050">
        <property type="entry name" value="AICAR_Tfase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002695">
        <property type="entry name" value="PurH-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005492">
        <property type="entry name" value="PRK07106.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00355">
        <property type="entry name" value="purH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692:SF0">
        <property type="entry name" value="BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN ATIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692">
        <property type="entry name" value="BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01808">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000414">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00798">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MGS-like" evidence="13">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMF10113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="598" mass="65513" checksum="140B1D9D2FF94C7C" modified="2013-05-01" version="1">MASETPQKIAILSVYDKTGLLDLAKGLIKQNIRLLASGGTAKLIREGGFPVEDVSAITKAPEMLSGRVKTLHPAVHAGILARDLASDEKDLAEQNINKVDYVICNLYPFKDTVAKINVTIPEAVEEIDIGGVTLIRAAAKNHGRVTILSDPADYHDFLQELSNGEVTEKQRQLYALKAFTHTADYDTAISDFFRKKYAGEGHQQLSLRYGTNPHQKPASAFTPNSPLPFKVLSGSPGYINLLDALNAWPLVKELDEALGYPAAASFKHVSPAGAAIGVPLSDVEKKVYMVEDIEGIDASGLAQAYARARGADRMSSFGDVIALSREVDVATAKIIGKEVSDGVIAPSYQPEALEILSKKKGGKYLVLQMDPTYVPPSQEQRTLYGVNLTQHRNDALISPQHTFNNVIVPKESKPLPESALRDLTVATIALKFTQSNSVCYSLNGQVIGLGAGQQSRIHCTRLAGDKADNWWMRFHERVLAIKWKKGTKRADKSNAIDLLTSGIVPDSGIEREAWEKNFEEVPTPFTLEERKSWLSKLSEVAVSSDAFFPFTDNIFRVGRSGVKYIAAPTGSQNDQACFSTAEQLDITFVEQHVRLFHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M3D251</accession>
    <name>M3D251_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal_S11-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_150198</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759318.1">
        <property type="nucleotide sequence ID" value="XM_016906014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D251"/>
    <dbReference type="STRING" id="692275.M3D251"/>
    <dbReference type="GeneID" id="27903151"/>
    <dbReference type="eggNOG" id="KOG0407">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072439_6_0_1"/>
    <dbReference type="OMA" id="IYASHND"/>
    <dbReference type="OrthoDB" id="1677536at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.80:FF:000002">
        <property type="entry name" value="40S ribosomal protein S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="entry name" value="Ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_uS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_uS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_uS11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_uS11_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007176">
        <property type="entry name" value="PRK09607.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S14/30S RIBOSOMAL PROTEIN S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF11197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="150" mass="15998" checksum="D57D8431CBFF4882" modified="2013-05-01" version="1">MAPKKAAPRVQENVQLGPQVREGELVFGVARIFASFNDTFVHVTDLSGRETISRVTGGMKVKADRDESSPYAAMLAAQDVAARCKELGITALHVKIRATGGNGTKTPGPGAQSALRALARSGMKIGRIEDVTPTPSDCTRRKGGRRGRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M3D2F0</accession>
    <name>M3D2F0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_150285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759438.1">
        <property type="nucleotide sequence ID" value="XM_016906067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D2F0"/>
    <dbReference type="STRING" id="692275.M3D2F0"/>
    <dbReference type="GeneID" id="27903204"/>
    <dbReference type="eggNOG" id="ENOG502S2WA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_2_0_1"/>
    <dbReference type="OMA" id="FEEHDPC"/>
    <dbReference type="OrthoDB" id="2363873at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051540">
        <property type="entry name" value="S-2-haloacid_dehalogenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316:SF4">
        <property type="entry name" value="ACID DEHALOGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316">
        <property type="entry name" value="HYDROLASE, HALOACID DELAHOGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF11317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="240" mass="26702" checksum="2EED33B63EF5BDB3" modified="2013-05-01" version="1">MPKSACFDVLGTCFDFQPAIDTIEARLGSQLRTVSADSKSLFFSWFYAAQRDFTYASVAGNYTPIAQILKLTLRRACAVVDLPLDRVSDEDVEAVMAQVRALVARPGLKKCYDGLREAGWDVYGVTNGGKEASLQYYALADVELDADHLLSCDEIRVAKPDAKVYQNAHSWLTKRGVGTEGDGDRWFVAAHAWDLIAARKAGFKTAYLYFEEHDPVTDVFGTFDIYANDMEELLEKLKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>M3D316</accession>
    <name>M3D316_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial</fullName>
            <shortName evidence="13">Glu-AdT subunit B</shortName>
            <ecNumber evidence="13">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SEPMUDRAFT_108114</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>L-glutamyl-tRNA(Gln) + L-glutamine + ATP + H2O = L-glutaminyl-tRNA(Gln) + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A, B and C subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the GatB/GatE family. GatB subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="13"/>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760741.1">
        <property type="nucleotide sequence ID" value="XM_016900719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D316"/>
    <dbReference type="STRING" id="692275.M3D316"/>
    <dbReference type="GeneID" id="27897856"/>
    <dbReference type="eggNOG" id="KOG1812">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2438">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_309310_0_0_1"/>
    <dbReference type="OrthoDB" id="1722066at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd20335">
        <property type="entry name" value="BRcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22584">
        <property type="entry name" value="Rcat_RBR_unk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00121">
        <property type="entry name" value="GatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017959">
        <property type="entry name" value="Asn/Gln-tRNA_amidoTrfase_suB/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006075">
        <property type="entry name" value="Asn/Gln-tRNA_Trfase_suB/E_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018027">
        <property type="entry name" value="Asn/Gln_amidotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004413">
        <property type="entry name" value="GatB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017958">
        <property type="entry name" value="Gln-tRNA_amidoTrfase_suB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00133">
        <property type="entry name" value="gatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004012">
        <property type="entry name" value="PRK05477.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659">
        <property type="entry name" value="GLUTAMYL-TRNA GLN AMIDOTRANSFERASE SUBUNIT B MITOCHONDRIAL AND PROKARYOTIC PET112-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659:SF0">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02934">
        <property type="entry name" value="GatB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02637">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26200">
        <property type="entry name" value="Rcat_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00845">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="GatB/YqeY motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01234">
        <property type="entry name" value="GATB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="59"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMF12620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="953" mass="105596" checksum="A6DEC1C4FE5DF3CE" modified="2013-05-01" version="1">MNEEVLELHVSDAATTSDSNDRLEALQLSLRGWPLFHLQRLGLSPGSWRDQLMEKGHQSDPVCLICGDSTSADTQILKLSCNCHHCNKCLTRLFTAAVTDESLYPPSCHRRPIPLNKVSRHLPLTLVRTYRAKSLELSTPNKVYCSNLKNGCNAFIAPHSIHNGQAFCQTCGMSTCVKCKEETHFGPCDDGTGNESGQNTTLLGLLNGLAKQEKWRVCPSCGRLVEKADGCNHILCRCGCDFCYSCGTLLDKCVCIDDDGLEEEEEDEEYEQGQADYHHRHRQEWAAREAANVLRRLRSRNRRELEEDIIEDTMVCISSGWPATQCPRPVDLDFSELHVIVFRFGTNMNFSAARTAPLLSPATAARSVPRTPRACFVAQWLQSRRNLSITPLRATPEPAIPLRKHLKDEAKRKKAEAKLSSVKKVKADPRLDKWELTVGIEIHAELNTACKLFSSAPALAGEENAAANTKVALFDAGLPGAQPQFQVATLLPALRAAVALGCDIQHKSGWDRKHYFHWDQPNGYQITQYYEPFARNGHLVLTPEDGVPSSDLDGADHLTIGIKQIQMEQDTAKTNAVGLSTYHIDLNRAGHPLIEIITLPQIHSPQTAAALVRKIQTILRSVDACTTGMELGGLRADVNVSIRERGTAGTGSTYSGVEGLGQRTEIKNLSSFKAVEDAIVAERDRQISVLESGGKIEGETRGWTLGAAETTRLRGKEGEVDYRYMPDGDLPPLIIGEDVVQYLKQTLPELPENTVERVVHRAGLSPKDAKTMVGLDDGDRLEFMEETIESLKQKWQEQTQPEDLHKFGKIVGNWVLHELGGLLDASVSWDDVSITPQELADIIYNLLQKQITARTAKQLLSALFDTPLASASRPSVEQLIETGNLRLRPLSEDAYTELAQAIMNENLDMVAAVRDKGQKGKIMWFVGQMVRRGEEGTVEPEMARRVVEKMLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M3D3M4</accession>
    <name>M3D3M4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">allantoicase</fullName>
            <ecNumber evidence="3">3.5.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_149159</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Utilization of purines as secondary nitrogen sources, when primary sources are limiting.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>allantoate + H2O = (S)-ureidoglycolate + urea</text>
            <dbReference type="Rhea" id="RHEA:11016"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:17536"/>
            <dbReference type="ChEBI" id="CHEBI:57296"/>
            <dbReference type="EC" id="3.5.3.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Nitrogen metabolism; (S)-allantoin degradation; (S)-ureidoglycolate from allantoate (aminidohydrolase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the allantoicase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.4" evidence="3"/>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760625.1">
        <property type="nucleotide sequence ID" value="XM_016905379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D3M4"/>
    <dbReference type="STRING" id="692275.M3D3M4"/>
    <dbReference type="GeneID" id="27902516"/>
    <dbReference type="eggNOG" id="KOG4145">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038797_0_0_1"/>
    <dbReference type="OMA" id="MDDGWET"/>
    <dbReference type="OrthoDB" id="10266039at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004037">
        <property type="term" value="F:allantoicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000078">
        <property type="entry name" value="DAL2p Allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000059">
        <property type="entry name" value="Probable allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00813">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005164">
        <property type="entry name" value="Allantoicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015908">
        <property type="entry name" value="Allantoicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02961">
        <property type="entry name" value="allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12045">
        <property type="entry name" value="ALLANTOICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12045:SF3">
        <property type="entry name" value="INACTIVE ALLANTOICASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03561">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016516">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Allantoicase" evidence="8">
        <location>
            <begin position="45"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Allantoicase" evidence="8">
        <location>
            <begin position="226"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00060607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF12504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="368" mass="40488" checksum="FE837FF04BF535F3" modified="2013-05-01" version="1">MAEAQVFTADAAQEVIDSVVKSIPADEIDATFKSDSIDLINKALGSRIISFSDEWFAAAENLTTPTPPIRKPGVFVFSGAWYDGWETRRHNTEEFDWVVIRLGVASGRVKGVEIDTFAFNGNHAPEVAVQGVFVGGEEEEEEVKKAEFWDGGKKRGVDTILARQECGPSQRHGWLLPALTEKAYTHVRLQMFPDGGIARFRLFGQVVPVLPQDVNEVFDLAATVNGGVAVSCSDQHFGTKDNLLLPGRGVDMGDGWETKRSRGEHVDWTIIKLGIPGLIEKIVVDTAHFRGNFPQKVQVFAAPAAENAPSADGSEWVEVLTPQKTGPDKEHEYTKQELSQIDQAYGYVKLVIIPDGGVKRIRVFGRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M3D3S1</accession>
    <name>M3D3S1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_85648</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760670.1">
        <property type="nucleotide sequence ID" value="XM_016910393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D3S1"/>
    <dbReference type="GeneID" id="27907530"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006937_8_1_1"/>
    <dbReference type="OMA" id="NYFQTFN"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050775">
        <property type="entry name" value="FAD-binding_Monooxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098:SF5">
        <property type="entry name" value="DUAL-FUNCTIONAL MONOOXYGENASE_METHYLTRANSFERASE PSOF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF12549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="549" mass="62560" checksum="B54DE3419EE9FDF8" modified="2013-05-01" version="1">MGSIETPPFQPEYDVLVIGCGLSGIYTVYRMRQLGLRVKALDAGSGEGGTWRSNRYPGCRFDSESVSYGFSFSQEVLDEWDWTETFAPGSETLKYAQFLTDKFDLRKYMQFSTKIVSAHFQEDTRLWLLTDSHGLTYSSRFLVTALGILSAPTLPNIPGAETFKDSFHSSRWPEDGDKRLKGKRVGIIGTGATGIQIIQTIVKPEYDVKSLTVFQRTPNWSAPLRNESLTKQDMVEIRKQYPKIFEQCLKSYSGFVYTADTRKTLEVPEAERLAFWEDLYAKPGFAKWLQNFADINTDREANAVFSKFIADKIRQRVHDPRIAEKLIPRNHGFGTRRVPLETNYIEAYNDERVRLVDVAEDDPIERITETGIQLQSGEHVDLDILIFATGFDAVTGPFHSIDFQGVDGAKLKDVWADGPRTFLGLFAHKFPNMCMILGPHQMFGNIPRSIEYAVDWVSSFLQTCYSNNPQKPITYFVAREDKIIEWTEHVHECAQGLLANEVDSWMTGVNKNVPGKEKRSIARYNGPGPGYRMRCEDVERRGYEDLVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M3D3U3</accession>
    <name>M3D3U3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rad21_Rec8_N-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_149420</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad21 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EMF12875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016905538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D3U3"/>
    <dbReference type="STRING" id="692275.M3D3U3"/>
    <dbReference type="GeneID" id="27902675"/>
    <dbReference type="eggNOG" id="KOG1213">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015775_0_1_1"/>
    <dbReference type="OMA" id="HTDLYEP"/>
    <dbReference type="OrthoDB" id="10071381at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030892">
        <property type="term" value="C:mitotic cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21788">
        <property type="entry name" value="Rad21_Rec8_M_SpRad21p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.580:FF:000004">
        <property type="entry name" value="Double-strand-break repair protein rad21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.580">
        <property type="entry name" value="Structural maintenance of chromosome 1. Chain E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039781">
        <property type="entry name" value="Rad21/Rec8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006909">
        <property type="entry name" value="Rad21/Rec8_C_eu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006910">
        <property type="entry name" value="Rad21_Rec8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023093">
        <property type="entry name" value="ScpA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585:SF69">
        <property type="entry name" value="FI11703P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585">
        <property type="entry name" value="SCC1 / RAD21 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04824">
        <property type="entry name" value="Rad21_Rec8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04825">
        <property type="entry name" value="Rad21_Rec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad21/Rec8-like protein N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Rad21/Rec8-like protein C-terminal eukaryotic" evidence="5">
        <location>
            <begin position="536"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="177"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="268"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="406"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="268"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF12875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="619" mass="68115" checksum="02C99024299594FB" modified="2013-05-01" version="1">MFYEASLLTKTGPLARVWLAANLDRKLTKTQVLHSNLDTNVKDIIGDAQAPMSLRLTGQLLLGVCKIYNKKAKYLMDDCSDALHKIKMAFRPGNVDLPSDQSHKANPAALTLPDTITELDLFAPMPDPEELLREPEERAPGQDPTLLDYGMSQIIDSQTPTRTQQRRTMALDYDDLGLDLGLPDEERARGSPDSDGPSIELGRRAPTPRRDEPTLLEVDDLGLDFGFDDTTLRQTTEQPDAPVLGGDEDLQMGGMDEEIEKANAHALERAKAAGEQRQRDSASPLSSVRSSVERDLERTFQLDQAMNEDEDETIAQAQQRVKRRKVIRIDHHTEFSSNELKKLQEDRSAITKAPTYLPHDPLLLSLMEMQRNGTFVSNLMGDGSMQGWAPELRGILSLEVVRSAGDKKRKRDSGIADVDSGSDKQATPQLEIPAEDDSGVQGGAGDLDATANDDAPVMMDDQDEELHEDEAYDAGVNFDITEAPLLHPSQSGPVAIGTKKMVHMLREHFAPGHPTDANEPPTPSKRVKSSALFTDLCPEKQTTRQDATKMFFELLVLGTKDAIKVEQESKGLGLPIRVRGKRGLWGDWAEMQSGGEIASQQEDAVARAEELASEVAAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M3D3W0</accession>
    <name>M3D3W0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_149218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760710.1">
        <property type="nucleotide sequence ID" value="XM_016905420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D3W0"/>
    <dbReference type="GeneID" id="27902557"/>
    <dbReference type="eggNOG" id="ENOG502SF87">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_371769_0_0_1"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="590"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="651"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF12589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="721" mass="80483" checksum="23054D9B16619ABF" modified="2013-05-01" version="1">MISILERTLLHDDRIEGKIRHTLFDLLHQEASLTGLRLTSHILHTIVDQRKSLMFSNLYFCMPVGRLDLKYNIPALRRIAPFCTSMTIKVTNGDANSPYTMGEAESGDQASAQESEQRKQESQNRRPARGVRNAHNTFRDDPSSESIAARPRRIGVQSSGVRKLDQLLLQQIFQSMYQLANLIIRVNVDSGWPGLTLTEDSLISIRLALEYSNLVSLRSVRLDPVHAAGVLHFRWAGFGAFREQPLTRSPDSPFSTTPRCGSEIWTNLSTLDLRLRNPVPAKRLNEKQMMMFFQVLDDYLRSFRRTLRRLCFVWLDAPGPSPLAFADLLERVPIVWQRVQEFQYGNITAPEKILDLVGHRMPNLRRLESLVATIGQDCQDGDVWKGVDIHLPGSNAPTSETVMGNAMAKLSQLSLVPPPLSFHQTPTRADSPARSALDSSSIYSHHELDLTDDPDIFDADGNVTVAMPSPSATLEEQRRTLQVHDVSSFGRAVRIGSSNDFVSTRRATNASVSRETPTRRNALVTRAPVASSVYSRDENGDYIPVRHKWTKSTVRSELRNTVSRSAMLPQPPAPAATDVKAGLSTTLRMPASRPDTVLPDNKRVGRMPPPVPSSNLIARNKHLEIGDMPGFKAARDEYLRKISSDQANAIVGRSAEGDDRASDNGTISSRDRVRHWARAVKSGRPPSVVTTKSIDTFKTTSSRPLSKFFANLRETGRPPRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M3D422</accession>
    <name>M3D422_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_149463</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016905568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D422"/>
    <dbReference type="STRING" id="692275.M3D422"/>
    <dbReference type="GeneID" id="27902705"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026447_0_0_1"/>
    <dbReference type="OMA" id="GPMNADH"/>
    <dbReference type="OrthoDB" id="1049195at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000145">
        <property type="entry name" value="Putative RNP domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000232">
        <property type="entry name" value="RNA-binding domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000280">
        <property type="entry name" value="RNA-binding domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF3">
        <property type="entry name" value="FI21236P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="88"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="218"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="393"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="167"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="176"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF12930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="490" mass="52753" checksum="029BD74150A20468" modified="2013-05-01" version="1">MGDRDRDYSRSRSPERRRDYGDRYDRDRSRSPDQQRERRAHTRDRSPRRGNGHYEESRSARPTRSAEERQQAKGEIMKSVAESSQQDRRVYVGNLSYDVKWHHLKDHMRKDGTLDVIFADVLLLPNGMSKGCGIVEYQTRDQAKIAIEQLSNTPLMGRLVYVREDRETEPRFSGPPRGGIDGGGFQGGGRGGFHSRGGFQGGMGGGYGGGMQQQGGRSQIFVSNLPYQVGWQDLKDLFRQAGNVIRADVHLGQDGNPKGSGVVAFETPDDAQNAINTFNGYDWQGRPLEVREDRFAGAGPGFGGRGGFRGGFGGGFGGRGGGFGRGGFGGFGGGRGGFQGGYSGGGYQGGGGYGQQGGAYAQGGGYNAPAPAQAPVAPNAFTDGVTSGGEANPIIHVKNLPWSTSNEDLVELFQTIGTVERAEIQYEPNGRSRGSGVVQFSNTSDAQTSIEKFQGYQYGGRPLGLDYAKYPEGGAMEGQESTGDLQAQMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M3D574</accession>
    <name>M3D574_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_149532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF13034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761155.1">
        <property type="nucleotide sequence ID" value="XM_016905615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D574"/>
    <dbReference type="STRING" id="692275.M3D574"/>
    <dbReference type="GeneID" id="27902752"/>
    <dbReference type="eggNOG" id="KOG2688">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017745_1_0_1"/>
    <dbReference type="OMA" id="IPCNIIM"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045114">
        <property type="entry name" value="Csn12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732:SF8">
        <property type="entry name" value="NUCLEAR MRNA EXPORT PROTEIN THP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732">
        <property type="entry name" value="UNCHARACTERIZED PROTEASOME COMPONENT REGION PCI-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="124"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF13034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="413" mass="45647" checksum="2C85128EFD39EC0D" modified="2013-05-01" version="1">MLLPVVNCAKLVCRLAIGLDKQPELVAHLKSDKADQDDGGPRDTLPERAADTLRKAFTTCLNDRAAALSSDGKPIGKKKGIYKIANICLKILFQCRKTRNATMIFENIGLQSPQLSAYPRSERVTYLYYLGRYLFQTNHFYRAQEALQHAYDLSPTAQQCVRQRRYILVYLVTCNLILGRFPSSALLQRPEAARLQQHFSPIMQAMRTGNLALFRQHLDFDSPSADWLLHFRILLPLRNRCEVHVWRSLVSKTWQISGEKAKADHVGNVVLQLKYLVQAFSLAEGLAQSPTDASYIDPEFDDEDEDDAEAAADSTPITVSSTSIESILSSLISQGFVNGFVSHRELRLIMTLMRHGNVVATGFPQPWSVIQQKVKGDVEVPGWRKHAQGGGLGGGGGGGRVVSLSGARAAGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M3D6A5</accession>
    <name>M3D6A5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_64902</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761831.1">
        <property type="nucleotide sequence ID" value="XM_016909695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D6A5"/>
    <dbReference type="STRING" id="692275.M3D6A5"/>
    <dbReference type="GeneID" id="27906832"/>
    <dbReference type="eggNOG" id="KOG1286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_12_1_1"/>
    <dbReference type="OMA" id="KTAYWRF"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF6">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="409"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="486"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="6">
        <location>
            <begin position="45"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF13710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="571" mass="62611" checksum="21C2CACFA81CCF05" modified="2013-05-01" version="1">MSLSSGERKIPTYATDDVHAIVTTADGEVVENSDALHRRLDNRQIQLIAIGGSIGTAIFVSIGGALAKGGPGSLFLAYAIYAIFLGLVNNGIAEMTILYPVSGGFVRLAGHFVDEAFGFMAGWNFFLYEALLIPFEITALTTVLGFWSSDIPAWAVPVACIILYGLLNCLAVKAYGEAEFWLSGGKVVLIFMLFAFTFVTMVGGNPDRDAYGFRNWNSPNAVAEYRSEGSLGRFEGFLACLWSASFTIVGPEYVSMVAAEAKRPRTYIKSAFKTMYIRFAIFFIGGALACGIVVAYTDPTLVGIVSGKSSGGGTASASPYVIAMQNLRINGLPHLVNALLCTSIFSAGNTYTYCATRSLYGMALEGRAPAFLRYCTKNGVPLFAFAITMIFPCLSFLQVGNGSAKVLGWLINLVTAGGVITYIVMSTTFIFYYKATQEQGLDRKSLPYYGWGQPYCAYLGLAWMIMIVTCYGYTSLNPFDVENFFIYYAMLILAPITFISWKLIHKTKFVKASEADLIWQRPTIDAYEASFVDPPNGFWREMIQLCSFGRKKFTEDRRRASAVVIDESEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M3D6G9</accession>
    <name>M3D6G9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cas1p-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_163170</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PC-esterase family. CASD1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761580.1">
        <property type="nucleotide sequence ID" value="XM_016908035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D6G9"/>
    <dbReference type="GeneID" id="27905172"/>
    <dbReference type="eggNOG" id="KOG1699">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008003_0_1_1"/>
    <dbReference type="OMA" id="WSAREWA"/>
    <dbReference type="OrthoDB" id="1932925at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012419">
        <property type="entry name" value="Cas1_AcylTrans_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13533">
        <property type="entry name" value="N-ACETYLNEURAMINATE 9-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13533:SF1">
        <property type="entry name" value="N-ACETYLNEURAMINATE 9-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07779">
        <property type="entry name" value="Cas1_AcylT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="365"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="401"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="494"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="549"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="631"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="691"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="734"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="927"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="domain" description="Cas1p 10 TM acyl transferase" evidence="10">
        <location>
            <begin position="460"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="665"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF13459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="944" mass="106083" checksum="2FAB07E16C9AE330" modified="2013-05-01" version="1">MALGYAFKKPLASDIFKSWPNAASKLSGVPFILVLVLLAGILLRHIVFDSDPYRCNALVTSGQWFKEDLRQWLIPGCSTAHYGRADVDACTDKKKREIVIAGDIHLQGTYWAFAERVGFGNKWPSFEEKDLVFEKDHVQLRYFFDPYLNGSSLLSRIESQGNAPQDRPMLMVVGAANYAIDHNRTEEYIATVQSLASTAISPGSRSLHGSKIDYTSGPGDLLLFTPPQKPSMSSRSDSDDEKNKKLLPYDKLDESLRELSTTNTLDVLWSFAAMTNGQRQNVYQSNGVFVTNEVSHRRVDVLLNLRCNARRANTGAFPNLATCCGSWRAPNLLQTTFLVLSIAILPAIVSADFKYEILSDSSRPGVRALSAFTAVVAISYVADRTHVFEQVTRLPLNKFNLFSMIIIAGVIGVLSIRRSKGPPPPRRPLPAAPAAGVATAATSAASPPLPPPPPSPSFPFLPRDQTDEWKGWMQLLIIIYHYNMAFWYDEFWQIIRLCVSSYLFLTGFGHTVYFLQKRDFSLKRLVNVLIRTNLLPCTLAYVMRTNWLLYYYMPLSTFWFLIVYATLAIGQKYNHRTLFLLFKIAFSAGLVHTFLSTKDLPETVVRFFVITCKMKFDTNEFFHHRVQVDQYIVYVGMVAAMLYIFLKDILSQQQQEEEESISILHDNNDSTKPHHHQNPPSLSRSRGKTNLILHLWPLLKRLAILLSLLTLPLFFHTTHTHLFRTHDQRPFATWQPYITFLPILSFTILRNAHPALRSHHSTIFAWLGRYSGEMYVLQDHIWLAGDQQAVLRTGIFGAAGAGDETVWGDRWRDLIVVTVGYLVGCRIVGDATGGIAEWFVREEGGSGSSGSTSSSSSSAAAAVWGRDGEGNKDEVEMGLLAGAAGSATRSSEYGEKFGQRRSWLQRVAVQVLSIKLRLWPTKLKNRVVLVLAIMWLLNVGILHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M3D6N6</accession>
    <name>M3D6N6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
            <ecNumber evidence="3 10">2.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_148993</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12125"/>
            <dbReference type="Rhea" id="RHEA-COMP:12126"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90510"/>
            <dbReference type="ChEBI" id="CHEBI:90511"/>
            <dbReference type="EC" id="2.1.1.100"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endoplasmic reticulum membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.100" evidence="3 10"/>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761951.1">
        <property type="nucleotide sequence ID" value="XM_016905273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D6N6"/>
    <dbReference type="STRING" id="692275.M3D6N6"/>
    <dbReference type="GeneID" id="27902410"/>
    <dbReference type="eggNOG" id="KOG2628">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065200_0_2_1"/>
    <dbReference type="OMA" id="ARYNTPQ"/>
    <dbReference type="OrthoDB" id="422086at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025770">
        <property type="entry name" value="PPMT_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714">
        <property type="entry name" value="PROTEIN-S ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714:SF9">
        <property type="entry name" value="PROTEIN-S-ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51564">
        <property type="entry name" value="SAM_ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="241"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF13830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="303" mass="33422" checksum="49F3FFED4160600B" modified="2013-05-01" version="1">MARVSASSSAGHSSGSGTANTNANNIPTSTSSAHPDVDATTLSQSLPPSDELPDTDWDEDVIDTTPLHMDDSLFPGGSRDLSWIGLQAFFLGLVAAAGISGTMIAISLQSTWWRLPAFATCLAIFHFLEYYTTARYNTNALRAESFLLFNNGRAYNSAHGLATVELIVSRIFPAYGRALVNPATIAIGVVLVLVGQAVRSFAMAQAGPSFNHVVAREHKETHKLVTHGFYSIFRHPSYFGFFYWAIGTQFLIGNKICLLGYILVLWKFFHSRIQGEEKFLISFFGDKYVEYRKRTGTMIPFIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M3D6T0</accession>
    <name>M3D6T0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N2227-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_43064</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761986.1">
        <property type="nucleotide sequence ID" value="XM_016908885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D6T0"/>
    <dbReference type="STRING" id="692275.M3D6T0"/>
    <dbReference type="GeneID" id="27906022"/>
    <dbReference type="eggNOG" id="KOG2798">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030612_2_1_1"/>
    <dbReference type="OMA" id="WSHHATE"/>
    <dbReference type="OrthoDB" id="978at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012901">
        <property type="entry name" value="CARME"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303:SF13">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303">
        <property type="entry name" value="CARNOSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07942">
        <property type="entry name" value="CARME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01296">
        <property type="entry name" value="N2227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF13865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="445" mass="49572" checksum="ECC2E3AAA740103B" modified="2013-05-01" version="1">MVHNLLYLSSIPTLLICIGIPLYISTTNNSNSSKPSSGSSISWSHNTATNLLSSLFERAAVAISPPSSSSSSLSTPLLPPGLAHSINSFEHYTHLASAIIHRKHTRYLQQNPAQRQLSQQVGYTAHFERARKGIEVNSRLLELMAKFARENYQTGLQSLQTEAGKEADLEDASMALYHLMRDWSAQGEKERQAVFPPVLEGLEKHFGGRRRRSGEEKEEKEEKKVLVPGSGTGRLASDIADLGFNVTANDMDYCSILAYHLLTNHTSALHEHTLQPFVTRWPHQANAFARYSSLTVPDHWPNKSVKLVEGDFLEMFPQDGEFDAVVTLFFIDMADNVIDFVSNIHRLLKPGGLWINLGRTLLSFLSFSSIQLCTPDPYSFTALKWGSYAELQLSAEEVVQLAELLGFDVDHSSRQSIDSVYAEPPDTLLKFTYGKCEASVPQARM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M3D8K3</accession>
    <name>M3D8K3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Heme peroxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SEPMUDRAFT_62816</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762571.1">
        <property type="nucleotide sequence ID" value="XM_016909612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D8K3"/>
    <dbReference type="STRING" id="692275.M3D8K3"/>
    <dbReference type="GeneID" id="27906749"/>
    <dbReference type="eggNOG" id="KOG2408">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033051_0_0_1"/>
    <dbReference type="OMA" id="ANWWGIV"/>
    <dbReference type="OrthoDB" id="823504at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031408">
        <property type="term" value="P:oxylipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09818">
        <property type="entry name" value="PIOX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034815">
        <property type="entry name" value="A_dioxygenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050783">
        <property type="entry name" value="Oxylipin_biosynth_metab"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903:SF11">
        <property type="entry name" value="ALPHA-DIOXYGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903">
        <property type="entry name" value="PROSTAGLANDIN G/H SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="13" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4 14" id="KW-0349">Heme</keyword>
    <keyword evidence="11 14" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0925">Oxylipin biosynthesis</keyword>
    <keyword evidence="3 15" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-0611">Plant defense</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="389"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMF14450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="628" mass="70659" checksum="879C332663905D20" modified="2013-05-01" version="1">MESPNFKPSLFDTIFIAIFHVVNLYIPWHRLPGLIGAFNLSFLRVELRQYNLHDGYASADHQGKLGDITGLNKRYIGTRNSDGTDNSLELRKMGCAGMRFGRSFNRKYCQKPTEDELWNPSPREVSLAFMAREPQDFKPATTLNLLAAAWIQFQVHDWFNHEDVSNDIAYDIPLRKSDPWPADHMKLFQTKPDTVLDPSDELCPGYRNANTAWWDGSQIYGSSESVTLSLRNNRPNGKLVLERVGTEDRFLPRDSDGTPKVGFSDNWWLGVELLHTLFALEHNAICDKIQQAHPEWTGGQVFDKARIVNCALMAKIHTVEWTPAILAHPALQIGMHANWWGIVGEQLTKAVGRVSKTSEDISGIPGSGVDHHGIPYSLTEEFVSVYRMHSLIPDNIALFGAVSGKHISTIPTEDVIFHKSLDAIKAGASFADAFYSFGINYPGAITNNNYPKVLQRLPTPDGQLRDMGTVDILRDRERGVPRYTAFRRLLRMSVPKTFEELTGGNKELAVKLSKVYGGDIDKVDTLVGSHSEPLVEGFGFSDTAFRIFIVMASRRLKSDRFIAGAWNAEMYTREGFDWVQNTTMSDVLERHFPELKALLPKKTNVFAPWDKLPESKAYPGMETNAPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M3D8R9</accession>
    <name>M3D8R9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable 26S proteasome regulatory subunit p27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_148219</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit p27 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762651.1">
        <property type="nucleotide sequence ID" value="XM_016904782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D8R9"/>
    <dbReference type="STRING" id="692275.M3D8R9"/>
    <dbReference type="GeneID" id="27901919"/>
    <dbReference type="eggNOG" id="KOG3129">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073146_0_0_1"/>
    <dbReference type="OMA" id="DWGGRGM"/>
    <dbReference type="OrthoDB" id="72325at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000107">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040815">
        <property type="entry name" value="Nas2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035269">
        <property type="entry name" value="PSMD9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12651">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12651:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18265">
        <property type="entry name" value="Nas2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nas2 N-terminal" evidence="6">
        <location>
            <begin position="32"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="146"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00068021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF14530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="234" mass="25203" checksum="5D6EAF23C32C11B9" modified="2013-05-01" version="1">MGLRMDDLHAPTVASGPTSQGIADGVQPERSLQELIAQKESLEAELSALGSVLDSHHVDMSTSLTTPDGFPRSDIDVAQIRTTRARIIRLKNDHKAIMKSLEEAVHKRFATGKPGEQTPTQSLQDTSSASAAAVPAPAVEPPFARVNSVVPGSPAEQAGMQAGDKVTKFGWVNWINHERLGKVAQVVQQNENHIILVKVQRQSEGAASSSHELRLTPRRDWGGRGLLGCHLLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>M3DAK1</accession>
    <name>M3DAK1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Glutamate decarboxylase</fullName>
            <ecNumber evidence="3 9">4.1.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_147090</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-glutamate + H(+) = 4-aminobutanoate + CO2</text>
            <dbReference type="Rhea" id="RHEA:17785"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="4.1.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.15" evidence="3 9"/>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763246.1">
        <property type="nucleotide sequence ID" value="XM_016904074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DAK1"/>
    <dbReference type="STRING" id="692275.M3DAK1"/>
    <dbReference type="GeneID" id="27901211"/>
    <dbReference type="eggNOG" id="KOG1383">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019582_2_2_1"/>
    <dbReference type="OMA" id="ECRDKNM"/>
    <dbReference type="OrthoDB" id="5152799at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004351">
        <property type="term" value="F:glutamate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006538">
        <property type="term" value="P:L-glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000017">
        <property type="entry name" value="Glutamate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.50:FF:000001">
        <property type="entry name" value="Glutamate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010107">
        <property type="entry name" value="Glutamate_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01788">
        <property type="entry name" value="Glu-decarb-GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321:SF6">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="476"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="487"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="505"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF15125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="516" mass="58315" checksum="4CD0B04BF80A3037" modified="2013-05-01" version="1">MVHLDRVENDKDLSEKVIPGLADLSFKSIPGEDDYSSTVYGSRFAATDLPKNEMPDDEMPREIAYRMIKDDLSLDGNPTLNLASFVTTYMEDEAEKLMVDAFSKNFIDYEEYPVSADIQNRCVSMIARLFNIPAHEDSTNAMGTSTVGSSEAIMLGTLAMKKRWQNKRKAEGKDYSKPNIVMNSAVQVCWEKAARYFDVEEKYVNCTEERYVIDPEEAVNLVDENTIGICAIIGTTYTGEYEDVKAINDLLVKKGIDCPIHVDAASGGFVAPFVNPNLVWDFRLEKVVSINVSGHKYGLVYPGVGWVVWRDPEFLPKELIFNINYLGADQASFTLNFSRGASNVIAQYYQMIRLGKKGYRSIMFNLTRTADYLAAAVEQMGFLLMSKTQGEGLPLVAFRLNPEHGHKFDEFAIAHHLRERGWVVPAYTMAPNANKIKMMRVVVREDFSRSRCDALITDLQMAVKELSKLDVKQLEDRTQQHRARRAVRAEKKKTNNHFSDEKHSLKGKTGKSHGIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>M3DAR6</accession>
    <name>M3DAR6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_36653</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF14929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763050.1">
        <property type="nucleotide sequence ID" value="XM_016908644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DAR6"/>
    <dbReference type="GeneID" id="27905781"/>
    <dbReference type="HOGENOM" id="CLU_3038177_0_0_1"/>
    <dbReference type="OrthoDB" id="5599418at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF14929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="55" mass="6395" checksum="AA777D7DD9991A35" modified="2013-05-01" version="1" fragment="single">LDLRNYTTVYLKKSLDTKYTKYIVEKVLLPVSVRLSGIPSNIYLVFYTDLLRPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M3DBX5</accession>
    <name>M3DBX5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_147409</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763686.1">
        <property type="nucleotide sequence ID" value="XM_016904284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DBX5"/>
    <dbReference type="STRING" id="692275.M3DBX5"/>
    <dbReference type="GeneID" id="27901421"/>
    <dbReference type="eggNOG" id="ENOG502SABA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1272965_0_0_1"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053187">
        <property type="entry name" value="Notoamide_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="133"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="178"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="194"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF15565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="217" mass="25653" checksum="168DA5EA206FDBD5" modified="2013-05-01" version="1">MEDNKNTHPPPKTRRAQVANACMKCRDAKLKCSSTRPVCDRCLDRKLACVYDVTEGMTKRQQDRVDLLDSGEQLHRRRMLLQFLQRARIEEAVEMLARLRSGYSLDSEYLRVQDRFRLQDGVFVLLEEEKQQQQQQQQGSSQRRTSTTTTSRTVPDAPTQEAIQREYLELIKWSNMPIDPQLLGEKGQQQQQQQRKDQQERQQEERHEQPEQQQQPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M3DCM7</accession>
    <name>M3DCM7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_105812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763690.1">
        <property type="nucleotide sequence ID" value="XM_016900595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DCM7"/>
    <dbReference type="GeneID" id="27897732"/>
    <dbReference type="eggNOG" id="ENOG502T948">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_536566_0_0_1"/>
    <dbReference type="OrthoDB" id="3649008at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="355"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF15569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="508" mass="57556" checksum="71C6E0EFC31A627C" modified="2013-05-01" version="1">MIIFKNHRLRVGYRKEDWHDVWYAPAAHYEPDDDDYSEFELYKSPYGGRTANEPTEGEVVWIGNFDIKQCESSDRKERMRKHRITLYRAWKYCDETDPEQVRRLEEELNQPDCRRWQSWFTHAKKWKRTKLQSRKRKRNDLVNSEPVQAVLASGTLLSEVDITSDSEDSAYGSEAEREMAEERRKKGLSMPPPPRPKRRRGRGRGKFSRKSRKGGGGDDDRANDNEDDFPPLMSGGLGDLDRSWTPRYNEPNGLGFIMNVPDEADPTKSARLKSTIKAGKKKYQATTIEGYLNDNSDLNVHDWEPDDENSNSMSASQFDARPPEGPPDLPAYDFPPTPQASQRTIDLGRNISGMAARNRAAAEQAARSSLSDHGVALRRGSRSESSSNAGVGDVGVNPAVGRDSRSGSHREGSVMDQRDRDNAGLDDDVALARALRLSERPGEDGYDEGPEENYEENYEENAEHDESAEHDENDGNDDNDDGDENDRIRRERRSSLARGDGDAVLDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M3DD42</accession>
    <name>M3DD42_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial</fullName>
            <ecNumber evidence="6">1.1.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Isocitric dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">NAD(+)-specific ICDH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SEPMUDRAFT_147539</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-threo-isocitrate + NAD(+) = 2-oxoglutarate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:23632"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.41"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Octamer of two non-identical subunits IDH1 and IDH2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.41" evidence="6"/>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763860.1">
        <property type="nucleotide sequence ID" value="XM_016904364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DD42"/>
    <dbReference type="STRING" id="692275.M3DD42"/>
    <dbReference type="GeneID" id="27901501"/>
    <dbReference type="eggNOG" id="KOG0785">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031953_0_1_1"/>
    <dbReference type="OMA" id="VRPCRYY"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045242">
        <property type="term" value="C:isocitrate dehydrogenase complex (NAD+)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000003">
        <property type="entry name" value="Isocitrate dehydrogenase [NAD] subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004434">
        <property type="entry name" value="Isocitrate_DH_NAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00175">
        <property type="entry name" value="mito_nad_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF34">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="15">
        <location>
            <begin position="52"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMF15739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="381" mass="41163" checksum="D33894CC92D3112A" modified="2013-05-01" version="1">MLARGIRAAASRHCMNTARPTFAQFAPRSYATAAADRIAKFPGQKGSDGKYTVSLIEGDGIGPEISQSVKDIYSAANVPIKWEPVDVTPILKDGKTAIPDEAIDSITRNYVALKGPLATPIGKGHVSLNLTLRRTFNLFANVRPCKSIAGYKTPYDNVDVHLIRENTEGEYSGIEHVVVDGVVQSIKLITREASERVLRFAFQYAQDIGRPKVRVVHKATIMKMSDGLFLSLANEIAKEFPNIDFDAEMLDNTCLKMVTDPAPYNDKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDECSIFEAVHGSAPDIAGQGLANPTALLLSSIMMLQHMGLTEHSAQIQKAIFKTLAEGKYLTGDLGGKAKTHEYADAIIKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M3DEX7</accession>
    <name>M3DEX7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Prolyl 4-hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_61606</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF16074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764195.1">
        <property type="nucleotide sequence ID" value="XM_016909568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DEX7"/>
    <dbReference type="STRING" id="692275.M3DEX7"/>
    <dbReference type="GeneID" id="27906705"/>
    <dbReference type="eggNOG" id="ENOG502QW74">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041456_5_1_1"/>
    <dbReference type="OMA" id="LRKPPNH"/>
    <dbReference type="OrthoDB" id="69177at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000020">
        <property type="entry name" value="Unplaced genomic scaffold supercont2.4, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF247">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="7">
        <location>
            <begin position="356"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF16074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="503" mass="55003" checksum="16EF5F607389C724" modified="2013-05-01" version="1">MAKRKRNNAHMSTASKKQAAGTTGIRTPPYEAHSDGPTTMASVVPAEDVEITLETLQALAAHPSVIKSKSCKDLRTAVFNFSQACTTGRNALTEGNSLTARISAALTDANYTEAMILLAEMRIRKETPSLGALCRWVRVLDVISGLAIHVEPSTKTIATRTPQNHELRQVLDAVLRVTGPTDPTALGTAAEPGTIALQSTWNLRDAQEPTRQTRASVEDKTIFKSCPPNLKEKFRIIETTPGVERKPPNLHPAVLFASQDDTVLLTNGPQTTVHNHPVVPNLRMIKDVLSPEECSSIIAAGETMEFIPDAPIRSDEDTSVLAHNFYWVVDQAFHDKLWDRVKAFVPESVTGRQVRGINRRFRVYRYVPGAEYRCHIDGAWPPSGIDPVTDAYQYDSSPPDARQSSLFTFLIYLNDDFKGGETTFFIPSCQEGVMNAYPVKPIMGSVAVFPHGEAQGALLHEGTGVVEGAKYVIRTDVEYDVGVTVPPSGESATVGIKRSVIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>N1QD76</accession>
    <name>N1QD76_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_151323</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757336.1">
        <property type="nucleotide sequence ID" value="XM_016906741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QD76"/>
    <dbReference type="GeneID" id="27903878"/>
    <dbReference type="eggNOG" id="ENOG502R0US">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_588161_0_0_1"/>
    <dbReference type="OrthoDB" id="3637419at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF09215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="465" mass="53493" checksum="4304D33FEFF71A28" modified="2013-06-26" version="1">MFLTHRLPDEIHVQILSWLDGFMSNRTANFRALCLTNRNGYRLATPRLYQTIGFDVDGKGRPEHLQKLCIAILCNPTLLSHVDTLHQYVGRMIKPSCFPLRDHMGLCRTALSQSGLDASCYEPILEALADPRYIGSIGSIAFLIVLCRRLGTRSSVGTFKLYIRWHWKEDDILARTLSSLGQSPGLCTVKNIELHDVIDRQHCCGLSLAEIMVFLQLPSLRSLVISRLGRFDQEHPFTLDLPERFDSALESLEILIVWYMTYLEALLVLCPRLKSLTVRWPNRWLLRQYFDAKKIDDWERDWVILVNALEELENLETLQILHRTEDYLHSPFPGWDGTPLRSLCGLGTLKVLTISDIALVGIEGFDPGNSSHREGDDSFQQAGLASLLPESLRELTILHYDIRLAGAIRLLARDPMVAKLDKFTVYHCHQIVWTAQDWMEDPLLAEIPKNIRRHMYYEEPPYWDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDT5</accession>
    <name>N1QDT5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_151640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757846.1">
        <property type="nucleotide sequence ID" value="XM_016906947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QDT5"/>
    <dbReference type="STRING" id="692275.N1QDT5"/>
    <dbReference type="GeneID" id="27904084"/>
    <dbReference type="HOGENOM" id="CLU_1256725_0_0_1"/>
    <dbReference type="OMA" id="WACLTSP"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="205"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="220" mass="19565" checksum="1E30AC9D30B36FC7" modified="2013-06-26" version="1">MQILTSFSTGIGGGVAGKGGLGAGAGVGGGAIWPGVGAGGQAGAGLGFGFGGNGGIGGGAKGGIGGQGGAGFGSIGNGNGPNYGSGSGSNKPSPNGGAPGGTESSPVPGKPNNSGPSGSPPASSPNAGNAPSYGAPQSGSPSDTDSSPVSGKPNNSSPSGSSPAYTPNAGSNAPSYGAPQSGSPSGTESSPVSGKPNNSPASPNAGGQAPSYGAPAPAPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1QE20</accession>
    <name>N1QE20_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase</fullName>
            <ecNumber evidence="4 13">4.2.1.134</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SEPMUDRAFT_69704</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 13">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:45812"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="EC" id="4.2.1.134"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Endoplasmic reticulum membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the very long-chain fatty acids dehydratase HACD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.134" evidence="4 13"/>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758636.1">
        <property type="nucleotide sequence ID" value="XM_016909871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QE20"/>
    <dbReference type="STRING" id="692275.N1QE20"/>
    <dbReference type="GeneID" id="27907008"/>
    <dbReference type="eggNOG" id="KOG3187">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034302_6_1_1"/>
    <dbReference type="OMA" id="SEWWLMY"/>
    <dbReference type="OrthoDB" id="46988at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102158">
        <property type="term" value="F:very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007482">
        <property type="entry name" value="Tyr_Pase-like_PTPLA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035:SF24">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04387">
        <property type="entry name" value="PTPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 13" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7 13" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="177"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMF10515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="215" mass="24811" checksum="412E30F9E10E28C6" modified="2013-06-26" version="1">MASSINPRKTYLTIYNLTFASLWTWIFLSTLSSTILSTSSSSSSSPTIFQTLSPRTRWIQTLSLLDILHSLTRLIPAPLFSTFTQIATRVIQVWLIWYTYPETTSEASFAFPALLLAWSAADAIRYVFLTLHLWGRAPRGLVWVRYSMFYVLYPVGIGAEWWLMFRAVRPAGEVSWVLGWVFWFLLGLYGPVGAYMMFTYMVKQRKKTLSKLEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1QE65</accession>
    <name>N1QE65_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2Fe-2S ferredoxin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_127952</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757293.1">
        <property type="nucleotide sequence ID" value="XM_016902180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QE65"/>
    <dbReference type="GeneID" id="27899317"/>
    <dbReference type="eggNOG" id="ENOG502SY25">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2428451_0_0_1"/>
    <dbReference type="OMA" id="KTTWHAK"/>
    <dbReference type="OrthoDB" id="5238236at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="3">
        <location>
            <begin position="11"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF09172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="91" mass="10058" checksum="31FF72DE7B4B2B69" modified="2013-06-26" version="1">MADIEDYPPSASVYFTKSNTKTTWHAKDNLTILQLAEQAGLHPQFGCRSAICGSCEVKITKGQVYGPEGDRPQGIFICQSRPATREIEIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1QEW1</accession>
    <name>N1QEW1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_156625</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Part of the multisubunit transport protein particle (TRAPP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Golgi apparatus</location>
            <location evidence="6">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAPP small subunits family. BET5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759773.1">
        <property type="nucleotide sequence ID" value="XM_016907687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QEW1"/>
    <dbReference type="STRING" id="692275.N1QEW1"/>
    <dbReference type="GeneID" id="27904824"/>
    <dbReference type="eggNOG" id="KOG3368">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053380_4_0_1"/>
    <dbReference type="OMA" id="GKLMYGM"/>
    <dbReference type="OrthoDB" id="3364529at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14855">
        <property type="entry name" value="TRAPPC1_MUM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.70:FF:000013">
        <property type="entry name" value="TRAPP complex subunit, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007233">
        <property type="entry name" value="TRAPPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249:SF16">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04099">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01399">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="4 6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF11652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="172" mass="19446" checksum="9D27382943C95653" modified="2013-06-26" version="1">MAGLSVYSFYIFDRHTECIYTKRWTTPPSRPSTTTNTTTTTSNNELPLSAKKALKLADDAKLIFGTIFSLRRMVRQLGGQDDQFLSYRTGEYKLHYFETPTQLKLIMLTDTRVGNMRTVLHQIWATLYVEYVVKSPLAPVEHPKGMGVANELFEGGLETFIASIFAPVQGVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1QF47</accession>
    <name>N1QF47_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Laccase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_136047</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757838.1">
        <property type="nucleotide sequence ID" value="XM_016902751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QF47"/>
    <dbReference type="SMR" id="N1QF47"/>
    <dbReference type="STRING" id="692275.N1QF47"/>
    <dbReference type="GeneID" id="27899888"/>
    <dbReference type="eggNOG" id="KOG1263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006504_3_2_1"/>
    <dbReference type="OMA" id="HNGTGIH"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13854">
        <property type="entry name" value="CuRO_1_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13880">
        <property type="entry name" value="CuRO_2_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13901">
        <property type="entry name" value="CuRO_3_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000021">
        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000045">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF502">
        <property type="entry name" value="MULTICOPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109804" evidence="5">
        <location>
            <begin position="22"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="99"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="6">
        <location>
            <begin position="222"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="7">
        <location>
            <begin position="438"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF09717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="617" mass="67395" checksum="290F996C6C91C21D" modified="2013-06-26" version="1">MKPSLLSTLTRALSLLTSVLATPVPEPLEFVNEYGALEAIPPEHRALDRRSPQSGDTACSNTANTRACWSNGFSIATDFDAKFPETGRDVIYDLEITNMTTLSPDGFNRLVLAVNGQYPGPTLIANWGDRMIVNVKNSLQHNGTSIHWHGLRQLNTVQHDGVGGVTECPLAPGETRQYILRCTQFGTSWYHSHYSAQYGDGVAGGIIINGPAVSNYDTDLGTMTFTDWYNDTAFQNNIRALHSTTGPPVPDSALINGTMKRADDMGSYHVTKVTKGKRFRIRLINIGIDNHFIISIDRHNFTVITSDFVPVKPYVATSVNINIGQRADIILTANQPIGNYWLRADIGDCGVNAYAGKVLSIIRYEGAPITDPTQQSTELINKPTACADEIVRPYVNNTVPQDQFTSAMQNISLGFNTTTTANNGSLVQWLIDGTATQIDWKNPTLDQVLSSTNNPSFALPNSSPNIIEIVSQPNSWTFWLLHTAPTNPVALPHPIHLHGHDFYILGSGGAGSTWNGDLSTLQFNNPPRRDTATMPAGGYLVLGFPADNPGVWLMHCHIPWHVGAGLSLQFVERRAEIDGVVNGAAAGGLGVHERTCEGWKRYWDGPGRVYEMDDSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFK6</accession>
    <name>N1QFK6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH TFE/IIEalpha-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_150608</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFIIE alpha subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758648.1">
        <property type="nucleotide sequence ID" value="XM_016906287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QFK6"/>
    <dbReference type="STRING" id="692275.N1QFK6"/>
    <dbReference type="GeneID" id="27903424"/>
    <dbReference type="eggNOG" id="KOG2593">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035744_1_0_1"/>
    <dbReference type="OMA" id="DAIKWKV"/>
    <dbReference type="OrthoDB" id="361102at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005673">
        <property type="term" value="C:transcription factor TFIIE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039997">
        <property type="entry name" value="TFE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017919">
        <property type="entry name" value="TFIIE/TFIIEa_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002853">
        <property type="entry name" value="TFIIE_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024550">
        <property type="entry name" value="TFIIEa/SarR/Rpc3_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097:SF7">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE, ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02002">
        <property type="entry name" value="TFIIE_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00531">
        <property type="entry name" value="TFIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51344">
        <property type="entry name" value="HTH_TFE_IIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH TFE/IIEalpha-type" evidence="5">
        <location>
            <begin position="5"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="300"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="351"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="218"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="304"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="357"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="377"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="429"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="439"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF10527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="451" mass="50095" checksum="F8BEA2744757127A" modified="2013-06-26" version="1">MADLATELIRTVSRAFYTTEHILIIDALMLHSTLQDSDLAHVLGTQVKPLRKTCGRLREDGLISVQSRAERRTDGTGGYYGGAPQQGKERLTHRDWYYINYHRAIDSIKFRMYKLSKHIESQGASTTEKKDLKCLTRGCGRAYTELEAMDSLDMATGDFLCAKCGAALEPVDEEERANENESMKRMNQQFAKLVELMQKIDAAAVPENDFETALSKQKPIEKADSHPGTRTEIVDVPNRNLQSTKGLEVKPEKIAVELKDDEDVKRESAAADARARKEKEARQNALPEWISKSTISGDITAVGAKEERQRLEREAHTGVLTHEEEEEKKAVKGDDDVMAAYWKELELAQKKEAELQKEEDEEDDDEEDEFEDVEGIAGTPNTANGAANGLAGTSTNGANTPANQESSNATDDERETKRAKMALPNGDKTPAQDTPAASDADDDDELEFENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFS4</accession>
    <name>N1QFS4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">26S proteasome regulatory subunit 4 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_149871</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760223.1">
        <property type="nucleotide sequence ID" value="XM_016905824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QFS4"/>
    <dbReference type="STRING" id="692275.N1QFS4"/>
    <dbReference type="GeneID" id="27902961"/>
    <dbReference type="eggNOG" id="KOG0726">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_2_3_1"/>
    <dbReference type="OMA" id="QDDTDPM"/>
    <dbReference type="OrthoDB" id="10255768at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036402">
        <property type="term" value="F:proteasome-activating activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070651">
        <property type="term" value="P:nonfunctional rRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045732">
        <property type="term" value="P:positive regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031503">
        <property type="term" value="P:protein-containing complex localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000030">
        <property type="entry name" value="26S protease regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000007">
        <property type="entry name" value="26S proteasome regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000039">
        <property type="entry name" value="26S proteasome regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 13" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="243"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="100"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="113"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF12102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="465" mass="51089" checksum="FB2C5487783FF63C" modified="2013-06-26" version="1">MGQNQSGLGGPGGPGGPGGDDNKKKDGKKDKPKYEPPPQPTTRIGRKKKKQAGPNAAAKLPTVYPTARCKLRYLRMQRVHDHLLLEEEFVENQERLRKAKTANEKAAPVGAEADDRNADERSRVDDMRGSPMGVGNLEELIDDDHAIVSSATGPEYYVSIMSFVDKDLLEPGASILLHHKSVSVVGVLTDDADPAVSVMKLDKAPTESYADIGGLEQQIQEVREAVELPLLHPELYEEMGIKPPKGVILYGAPGTGKTLLAKAVANQTSATFLRIVGSELIQKYLGDGPRLVRQLFQVAAENAPSIVFIDEIDAIGTKRYDSTSGGEREIQRTMLELLNQLDGFDDRGDVKVIMATNKIETLDPALIRPGRIDRKILFENPDQNTKKKIFTLHTGKMNLAEDVDLDEFISQKDDLSGADIRAICSEAGLLALRERRMRVNMTDFRAARESVLKTKTEGEPEGLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFX8</accession>
    <name>N1QFX8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NEDD8-activating enzyme E1 regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_72146</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Regulatory subunit of the dimeric UBA3-ULA1 E1 enzyme.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757559.1">
        <property type="nucleotide sequence ID" value="XM_016909973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QFX8"/>
    <dbReference type="STRING" id="692275.N1QFX8"/>
    <dbReference type="GeneID" id="27907110"/>
    <dbReference type="eggNOG" id="KOG2016">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019618_1_0_1"/>
    <dbReference type="OMA" id="KLITHQY"/>
    <dbReference type="OrthoDB" id="1708823at2759"/>
    <dbReference type="UniPathway" id="UPA00885"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019781">
        <property type="term" value="F:NEDD8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030667">
        <property type="entry name" value="APP-BP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF29">
        <property type="entry name" value="NEDD8-ACTIVATING ENZYME E1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039099">
        <property type="entry name" value="APP-BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="5">
        <location>
            <begin position="24"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR039099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF09438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="568" mass="62504" checksum="D8B5D49CC47C6F29" modified="2013-06-26" version="1">MANGPPTDVPPPLQDIPTAKEKKYDRQLRLWGAAGQIALEESNILLINNGPGVTGIETLKNLVLPGIGTFTILDSAIVEQADLGVNFFLEDASLGKFRAEETVKYLEELNPDVKGHAITEPIASWAVKDKILSPYTLLLIAAPLDPAILTLLQTHIHALQVPTFYIHCLGFYTHFSLYLPPAFPIVETHPDPTATTDLRLLKPWPALSEFAKKQTMDMDKMNGEEFAHIPYVCLLLHYLEKWKAAHDGKLPESYKDKTAFRELVRSGSGSEENFDEACAAVLKSLNPPTLPSTVRDILTAPETLQLTPTSPPFWLIANAVQQFYQKHAQLPLPGAVPDMKARSNTYIELQNIYKTKARDDVAEVLAQVRALEHSTQRLPSLPAIDEKEVELFCKGAAHISMVRGRPFQVVQPGVAIAFGDRAKYVYNNLTNPESLVGLYLAFLAWDEFCATHTSDEAGGEALRVAGAGDEFEQDAEKLTGIACKLVDAAISEAGTRIEDPEYSDIKQKVGQYCLELARAGGAELHNIASLSGGLIAQEVIKVITKQYVPMDNTCLYDGVTSRTWVGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFY7</accession>
    <name>N1QFY7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cytochrome P450 monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_87793</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760308.1">
        <property type="nucleotide sequence ID" value="XM_016910454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QFY7"/>
    <dbReference type="STRING" id="692275.N1QFY7"/>
    <dbReference type="GeneID" id="27907591"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_27_0_1"/>
    <dbReference type="OMA" id="TDLLWSM"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002974">
        <property type="entry name" value="Cyt_P450_E_CYP52_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002402">
        <property type="entry name" value="Cyt_P450_E_grp-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF18">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE APDE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00464">
        <property type="entry name" value="EP450II"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01239">
        <property type="entry name" value="EP450IICYP52"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9 12" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="461"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602402-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF12187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="522" mass="60403" checksum="6C0DD5C64D7C23F8" modified="2013-06-26" version="1">MSLLQHVVYAGLAGIVAVTVLRWVSQQISHIRFKRAMGCGDIPRYPHIDRIFGLDIVLGMAKSLKYDYFLVWLNQVHRGLPKTFVVNFLWSRFIWTIEPENMKCMSATNWRDFAVGPMRRNNKATHPFADKGVNTVDGKEWEFSRTLIKPFFVAEGFKNTGRLSGHVDRLFARFPADGETFDIQQLVQLWFLDTTTEFLFGESIGSLEHPERASLCWAMVDVLRGLRLRLQWYKYLFLFRHQSWLDAVAVVHDFLNRHLDRTWRELEEKEEKERENEDKRSRGETAVAERAERTDLLWSMAGQLRDKEALRSQLCLIFVPNNDTTSIFISHILWNLARRPDIYARCRAEVLAHGDAELSFEALRSMKYLNAVMMETHRLHPNGVTQVRKCINDTILPCGGGRDGKSPIHVRKGDVVQVNKNVLHRDPDIWGEDAEDFNPDRWDGLRPYWTFVPFGGGPRRCPAQMLVTVEASYMLARIMQQFRRIEARDPAPYVGVMRVGPSNKTGVKVALFRDDESAFACR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGA4</accession>
    <name>N1QGA4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_134200</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760443.1">
        <property type="nucleotide sequence ID" value="XM_016902618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGA4"/>
    <dbReference type="STRING" id="692275.N1QGA4"/>
    <dbReference type="GeneID" id="27899755"/>
    <dbReference type="eggNOG" id="KOG1176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_2_1"/>
    <dbReference type="OMA" id="IWASKCR"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF317">
        <property type="entry name" value="ADENYLATE-FORMING ENZYME AFEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="7">
        <location>
            <begin position="172"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="8">
        <location>
            <begin position="587"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF12322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="689" mass="76660" checksum="EB6A3AAB163BCA87" modified="2013-06-26" version="1">MASHKEGLLPDSPPLSLARVQKRRTRSSFSWNSQDHHSQCHQATRLQRRQLFLVLAQLQRLSKDEEERKKQAQDSFTTVPTLSSTPVELFSTSSQNGIPPYNPHTTTALETGATMPVSVSSLAAEDANIVQWAFSGQYDSNVPVLIDAEEPTRYITKEKAIQLTANLTGAFEENTTVCLNIPNDIVYPILCYAIWASKCRWTGVNPGYQSVDLTHHFRTSETKYVITCEEQLEKIREAVRDCGRDVEIILYSDLLKPQPAREQTACGVHHGHCHRNQSSEFRYLHELQKTKTPESLFEALSQVDNTSIAALASTSGTTGLPKMAARTHKSHVLEAAAAQDNHAAKPYPVRRLFCTPIFHSFSTGEMAINSMRLGQPTYFIKRFDPKIFPQAILDFQITETFAPPPLIMRLVDNPDAHAQIQSLRNIYCGGAPLVPELKNRLDAIYLNNPHGPPRIAQVWGMTEGGWFTTFKYGENDSTNSVGRPIPGYEIRIVPRPDFHTTTTTTTTGEETIPETGELYIRGPNLLMTCYFNNPEATADAFEDDGTTSGWLKTGDVGYISPQDGKVYLIDRCKDLIKVNGFQVSPTELENALLTLPGIADAGVVGALSGTTGEHPVAFVVRQVVHDDEEEEEEKKGSGEDGLITKEQVKARLRRQLASYKVSMMEVVFLDALPKSITGKILRGKLRELC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGB7</accession>
    <name>N1QGB7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_118276</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760468.1">
        <property type="nucleotide sequence ID" value="XM_016901413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGB7"/>
    <dbReference type="STRING" id="692275.N1QGB7"/>
    <dbReference type="GeneID" id="27898550"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_279532_0_0_1"/>
    <dbReference type="OrthoDB" id="5599418at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="711"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF12347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1127" mass="129108" checksum="E755A9127BDB76C3" modified="2013-06-26" version="1">MFQLSPKFRDDTITLSKAPREPRGKNKKKHVTEAYLGVGADNEETEPTINREMHKISNVSAVNRMPSDTEVTTDFRAHLGKEGKLFSVAVEVDEYEPPSPTFEELLPEPKSRPRVLVPRPAAPTITEKTQEDTAVLLAAVKHNQLYFEWKIQETADPSDLLVPYRYGLRFYCLKYPDPDCRSVNTVRPATVFETKTTEPPKQPFPVERRVVRLNTTDVLGPEEVDDWFKHRGFPAVGLLATTEEQRDKDIPPIDLIHHRVRLKEGTPVHSTKQRRYAGQKEYWLRRIIQDGIDAGMYEKTFYANGKLSEWNTAPMIVPREGQEQPRLVFDYYWVYEDQPGNWMHNQEAVHNFLSNPSYKLYFQFDIKHAYWSVPIHPDDRYLLAFSVLGMGQYQLTRMLQGERSASFTMTELMHIALGAILPLDPEPSLMYGGERPDVQHCSVFIDNGFGAIGDSIPDDRVFIEGYDYLKKLRMLNIRFEWIAGKKNAAADGLSRTIFEFDEDESIKETPMIRDLANKVTVHPLGDEWYWKTSKGSYQDKLKQLTAKMVRTYQAHSVDTVLSIGFTDEGPYPLGWTSFSVTTTSQPMKNTELERSLWYGDMYRYCTTGELPPVDAAKRAAFKRQSMHYRYNERNGRLLYQRTKTSKWAVCLLPREVGPLLQQVHDDKGHFHADITIKKLSGVYWPNIASNVREYILGCIQCARYTNRTRSQPQQPIEVMGPWQLFGMDWIGLFPETARGNRYVLHLIDYFDRMSFTSAAPGCSARDTVDGLAAYIAYYPTPAAIFCDPGKHYVAKETRQFCKLNGIYLAYALSGASRPVGMVEKANNILQKTMMKSVAILMEADLRGFVESYPNWDLDLDKQIAFGYKPSDMQPTEWALPTPSKQDLLDWFTAPDFDIPRDSEMALLVYTFMARRQGVLEDVQERDNTRRDRQKTRYDAGTPEQNNISYLQVPETAGPFYDPTKPQILRGEYLGLYEALRDKKILVPFFGVGKSVIKDSQGQYTVGHTMEISAQAKAELAFREEAHLYLCNAELIVGSKMLAYRFDGGQMSRQDRAKHFVQYTELVYDEKPPLGAIAPFHLLQLLIAYPKAGITGYDFSDGWKLKGGQLDSQFPETGLDMLIFDVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGG9</accession>
    <name>N1QGG9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Enolase C-terminal domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_150886</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759068.1">
        <property type="nucleotide sequence ID" value="XM_016906453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGG9"/>
    <dbReference type="STRING" id="692275.N1QGG9"/>
    <dbReference type="GeneID" id="27903590"/>
    <dbReference type="eggNOG" id="ENOG502QU7C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030273_2_0_1"/>
    <dbReference type="OMA" id="SGAIDVC"/>
    <dbReference type="OrthoDB" id="14161at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050023">
        <property type="term" value="F:L-fuconate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03324">
        <property type="entry name" value="rTSbeta_L-fuconate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.120:FF:000007">
        <property type="entry name" value="Mitochondrial enolase superfamily member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034610">
        <property type="entry name" value="L-fuconate_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018110">
        <property type="entry name" value="Mandel_Rmase/mucon_lact_enz_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046945">
        <property type="entry name" value="RHMD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13794">
        <property type="entry name" value="ENOLASE SUPERFAMILY, MANDELATE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13794:SF58">
        <property type="entry name" value="MITOCHONDRIAL ENOLASE SUPERFAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00111">
        <property type="entry name" value="L-fuconate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00270">
        <property type="entry name" value="L-galactonate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00179">
        <property type="entry name" value="mandelate_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00909">
        <property type="entry name" value="MR_MLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mandelate racemase/muconate lactonizing enzyme C-terminal" evidence="5">
        <location>
            <begin position="201"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF10947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="451" mass="50180" checksum="E5931640C29C3E6B" modified="2013-06-26" version="1">MSSLTITSITTRDVRFPTSLDKTGSDAMNAAGDYSAAYCIIHTTSPSLSGHGMTFTIGRGNDIVCHAITALSERIIGKTLSSLTSNWGQTWRYLVSDSHLRWIGPEKGVIHLALGAVVNAIWDLWAKELGKPVWRIVADMSPEEFVQCIDFRYITDAITPKEAVDMLKEMEAGKKERIVEAEKNRAVPAYTTSAGWLGYGEDKMRSLLEETVQQGYKHFKVKVGTDVEVDRKRLGIARDVIGYDKGNVLMVDANQVWSVPEAIEYMGHLAEFKPWFIEEPTSPDDVFGHKQIREALRPLGIGVATGEMCQNRVIFKQLIVQGAIDVCQIDACRMGGVNEVLAVLLIAKKYGVPIVPHSGGVGLPEYTQHLSTIDYVVVSGKLSVLEYVDHLHEHFLHPSVIRDGYYTTPTEAGYSVEMKAESMDRYEFPGKEGVSWWRTEEARPILEGARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGT0</accession>
    <name>N1QGT0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glutathione synthetase</fullName>
            <shortName evidence="10">GSH-S</shortName>
            <ecNumber evidence="10">6.3.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SEPMUDRAFT_66837</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <reaction evidence="10">
            <text>gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)</text>
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            <name>Mg(2+)</name>
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        </cofactor>
        <text evidence="10 12">Binds 1 Mg(2+) ion per subunit.</text>
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    <comment type="pathway">
        <text evidence="1 10">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.</text>
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    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
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                <person name="Dhillon B."/>
                <person name="Glaser F."/>
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                <person name="Salamov A.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A N-terminal" evidence="3">
        <location>
            <begin position="159"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A central" evidence="2">
        <location>
            <begin position="390"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF16485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="754" mass="82305" checksum="ACE63377B897EF39" modified="2013-06-26" version="1">MLCSLCWTRFFVVGVVLFFFFGLCLWHEAEVQNVLLSSSSSSRFESRVVSFIMAPVGYTSILLSFVWSLLFSISPQSTHAAVVGLPSYPLAVKSPYLSTWLPSKQALDVAGGQPEFWAGQGLNWPVLARVDGTLYALLNGGSASNAVKAVTKGITYSSTHTIISLYGGDVNFTLDFFTPVYPASADYLLQSLPYSYLTVNASVADGRAKNVQVFSGIDHTWTAQAGAAQINLTTSGDAQFFWFYNPRQSYYTEKADQATYGSVLYGSLSSDGETSHGIGPATDLYSEFAASGSLTGSTSPTSGTGLVAIVQDLGAVSDTPVGTTVAVGLQRDIAVQYLGRDQTSYHRKKWPFIPDAIEFFLNNYNRAREYSAILDDLVRSNSEAVSCDWGSAYADINEASVRQSFASLELTVPNDDRSAEVSAFLKEISSNGNMNTVDLIFQSWPIFVSLNPEWIKLQFKPILSYLASGRWPKPYVIHDIGLHYPIATGHDDGIAEEMPLFETATMFILLLAYQKFSGDTTFAAQYRSLFDGWANYLAENGLYPANQLISVDAIPPSANQTGLAVQSAIGLKAAAVLTGNDTYATIADTFVTKLYDDALGLDGPDLASSTHFTYNYDKPTTWNVLFTAYSDVILDLHTFPPEAWDLQSTFYSSVFQPYGLAFAGPVSDRGIQWGITDWNLEWAAIATEELQKSIVQTTHMFMTNGKNTIPFGTKYFVQGTEAGVWIGNKARGSVGTHFAIVALQQGVWDYESAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2023-02-22" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>N1QHP4</accession>
    <name>N1QHP4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_149786</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760090.1">
        <property type="nucleotide sequence ID" value="XM_016905767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QHP4"/>
    <dbReference type="GeneID" id="27902904"/>
    <dbReference type="HOGENOM" id="CLU_2016653_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF11969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="123" mass="13007" checksum="0711F97AA38088B8" modified="2013-06-26" version="1">MLYGASAVGTHPAALTRQSCCSYAAVELVQNSMAKNCQKNGHSLAGVELVPRNNKKSVLGCILYICFAIPTQPFELACVSERCTVQLGVTLEAGKAYLAEPGLSVLTRSYDGLYSHHGPSSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1QI41</accession>
    <name>N1QI41_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Short chain alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_70330</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758954.1">
        <property type="nucleotide sequence ID" value="XM_016909901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QI41"/>
    <dbReference type="STRING" id="692275.N1QI41"/>
    <dbReference type="GeneID" id="27907038"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_2_1"/>
    <dbReference type="OMA" id="TAGPCII"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF133">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF10833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="271" mass="29849" checksum="1361471462FD391C" modified="2013-06-26" version="1">MLKTAIISGGARGIGRSLVRRFLEKGYKVFVLDIDQEELTHAVKNHLQKYSDDKLLGFRICDLRNVDDIQKAIDEAAKFLGGRIDVLVNNGGIANPKWKDNQTMLNKETIPQWQAYIDTNLTAPFVVSQACLPYMKNEARLQDWNTSEAGPCIVHIGSFRAFQSDANQEGYASTKAGLLGLTHSMAASFKPFGIRVNLVAPGRIKVAHECKEGDEKGTQWSELNEEKDVADHLANRAGRPKDIADAVEYLVNAGFVTAEDITIDGGATKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2023-02-22" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>N1QIJ7</accession>
    <name>N1QIJ7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_150521</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758520.1">
        <property type="nucleotide sequence ID" value="XM_016906234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QIJ7"/>
    <dbReference type="GeneID" id="27903371"/>
    <dbReference type="HOGENOM" id="CLU_2172665_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF10399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="110" mass="12842" checksum="0ABA599DD99A1986" modified="2013-06-26" version="1">MDAQHQKTNKSAQFACYLREHTYIIEYYILHLSFRAAVPPLYPFVPLPIQRIQAGLPGKQASNKRGRKFLGTTFFFLSFLVTETKGCDKNYLHTYLPYLITNRRLRTAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>N1QIZ6</accession>
    <name>N1QIZ6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="4">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_89765</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA polymerase type-B-like family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="4"/>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758685.1">
        <property type="nucleotide sequence ID" value="XM_016910509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QIZ6"/>
    <dbReference type="STRING" id="692275.N1QIZ6"/>
    <dbReference type="GeneID" id="27907646"/>
    <dbReference type="eggNOG" id="KOG2277">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002806_0_0_1"/>
    <dbReference type="OMA" id="EACEQYV"/>
    <dbReference type="OrthoDB" id="2274644at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF113">
        <property type="entry name" value="POLY(A) RNA POLYMERASE CID11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="10">
        <location>
            <begin position="123"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="9">
        <location>
            <begin position="346"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="455"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="559"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="747"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="815"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="905"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="999"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="469"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="492"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="659"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="817"/>
            <end position="836"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF10564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1083" mass="119122" checksum="A1FB30A40E71D2E4" modified="2013-06-26" version="1">MAGLPNGSRFEQAQAVIPRPGIYSHHSNSVPSTPHQKPRDLGRFHSRSPSPHRGLANQSPHSVASEAVDTQKSSRANTGVCAFESGSEFRKRRIPYVDGGNEELAAPKKEPKKTLSPDEQKKLTADMLHLYDQLLPNIDSEARRKRLIEKLERILKEKWPGHDIRVNVFGSSGNLLSSKDSDVDICITTELKQLQSMHSLAEVLHNNGMVKVVCRPNAKVPIVKCWDPELRLSVDLNVNNSLALQNTRMIKTYVQLDKRVRQLAKIIKHWTKCRILNDAAYGGTISSYTWICMIINFLQRRNPPILPSLQKISDCRTTLESGELSPFADDVDAIKRKGLGPENKETLGELLFQFFRHYGYEFEYSKYVVCVREGRAVSRKEKGWDPKINYQDKESRVRLCVEEPFTQDRNLGNSADDYAWYGIHQEIRRAFDLLADGLQLLKCCEEFVFPPEPKRAIFERPTPKPKPTLTRSVSQSNRTNLDPSGRSRKSNRQGSGQRAGNRRASSGAAYSHHRSGVPFSPPLGANPSDYFQVKGGLHEQLFQQYQFLQAQQDALRHQLERQQHVATSARGSDLAGSPRPRQYTNGLASPRFADHPPQSAPLLPGYLYHYPAAPRYPPPSNMSQARQRDGADTNPSSPSLVAAMPAIRRNGHRGSIPDASASSARSQSQPGRSLPHPLTLQQHVHPGYDVSGVLNSHRSVPQMYAGHPGLALPLSAQFPGVHTAGLTQDSTMPKEYVGYFSSPQLGPQQFASSSQLPPPAMTLRDPPTRQRRVTPDLAPPLINGRHSSRSPSPLNHLRGLSLQGDVAVEPPLFIERPTTNGQHSSASTLPPTPVTTSDPVLVNGSTGGPVIVNGSTRAPAPKSAEQTLTNGIAGPGIQLQNEIPFVAQPEDLPRLRPVQVRTNFEQSSSDLMPEGVPPTRHSTSDVRASLSPNGTHLNGLDGHHHELSPVTTAMLSPVAELRTPSPTHTRVFEHDYPKTNGLLKTAKVTDAKQVLNENQHSKAGVKVEHERKGSAPVPSAPGNASKGMTIQPIPPYVPSPKNEWQTASGGKNKHKKNKSIAGARANGVGAQPFPPFDFERKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJ00</accession>
    <name>N1QJ00_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 18">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="7 18">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">SEPMUDRAFT_146246</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 19">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 18">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="7 18"/>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765276.1">
        <property type="nucleotide sequence ID" value="XM_016903538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJ00"/>
    <dbReference type="STRING" id="692275.N1QJ00"/>
    <dbReference type="GeneID" id="27900675"/>
    <dbReference type="eggNOG" id="KOG1367">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025427_0_0_1"/>
    <dbReference type="OMA" id="DMIFDIG"/>
    <dbReference type="OrthoDB" id="275353at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00318">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000019">
        <property type="entry name" value="Phosphoglycerate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000031">
        <property type="entry name" value="Phosphoglycerate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="entry name" value="Phosphoglycerate kinase, N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015911">
        <property type="entry name" value="Phosphoglycerate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406:SF0">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00111">
        <property type="entry name" value="PGLYCERATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="12 18 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 18" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="24"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="66"/>
            <end position="69"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="375"/>
            <end position="378"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00016471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU000696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EMF17155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="420" mass="45080" checksum="088CC0783916938C" modified="2013-06-26" version="1">MSLSSKLSITDVDVKDKRVLIRVDFNVPLDKETNSKITNNQRIVGALPTIKYAADHGAKSVVLMSHLGRPDGKPNSKYSLKPVAAELEKLLGKKVTFTEDCVGPEVEKVVNEQSNGGVVLLENLRFHAEEEGSSKDKDGNKTKADKADVEKFRKGLTALGDVYINDAFGTAHRAHSSMVGVDLPQKASGFLVKKELEYFAKALENPQRPFLAILGGAKVSDKIQLIENMLDKVNSLIICGGMAFTFKKVLDNMEIGNSLYDEAGAKKVKELVEKAKKQNVSITLPVDYTTADKFAADAKTGYAEDKDGIPAGWMGLDCGEKSIELFKKTINEAKTILWNGPPGVFEMKAFEKGTRATMDAAVAAAQDGKIVIIGGGDTATVAAQYGVEDKLSHVSTGGGASLELLEGKDLPGVSALSEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJ72</accession>
    <name>N1QJ72_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial import inner membrane translocase subunit TIM54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_77374</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIM54 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765402.1">
        <property type="nucleotide sequence ID" value="XM_016910160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJ72"/>
    <dbReference type="STRING" id="692275.N1QJ72"/>
    <dbReference type="GeneID" id="27907297"/>
    <dbReference type="eggNOG" id="ENOG502QPMQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039097_1_0_1"/>
    <dbReference type="OMA" id="RNWMIFF"/>
    <dbReference type="OrthoDB" id="5598305at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021056">
        <property type="entry name" value="Mt_import_IM_translocase_Tim54"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11711">
        <property type="entry name" value="Tim54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="178"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF17281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="421" mass="47377" checksum="C0EC7DAED1B5F29E" modified="2013-06-26" version="1">MGLPRLRLPSRNWSIFWTITGSFAAAVMYDKYQTKRTREKWVQLVAHVADEHLDIKTLPRRVTIYLQAPPGDGLRTAREHFHLYIKPVLVAAAMDWDVVEGRQEGDVRHKTAEKIRKWRRRKGEGEPETAEDDGTLTVEALREKNGDVEYPGVAGDIVVGRHAWKEYIRGLHEGYLGPADLPKDPKEHESTTPAHHDDMGDSPVSSLDTVVGDSPPVTEAQTSEETLSGEALTSDDGKETRKEGEAKTKAEDEKPKRRFPPPSILPGDYAAASLSPFTPEILGPSVAVRLPHLLGFLNTPTRIYRFLNRRRVQDDIGRQVAAVVLAAHRPYTTAASYDASSASEMQVEVREQAGLLSHEEKDWYKLVHRPRQEHEESLWTEPVVLDERISSRMRAFELSAADEARARRIAAGEEEKAQHET</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJ83</accession>
    <name>N1QJ83_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_130036</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765371.1">
        <property type="nucleotide sequence ID" value="XM_016902327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJ83"/>
    <dbReference type="GeneID" id="27899464"/>
    <dbReference type="eggNOG" id="ENOG502RZJU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095770_2_0_1"/>
    <dbReference type="OMA" id="WEYSVES"/>
    <dbReference type="OrthoDB" id="2679825at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054208">
        <property type="entry name" value="DUF6914"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21858">
        <property type="entry name" value="DUF6914"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF17250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="192" mass="21969" checksum="BD0335D38E1E16BB" modified="2013-06-26" version="1">MPRNKQRLYLALYSRTGITPSMPGKEDAYYWALLIGPKNENKSSQGIKCHAKTIITFDDSIKGKETAIMTFQYEERKIWLTAVDSILVRLVLAKVVETDRLLDVLRGTRVKKHGDAGGWNCVHWTRDALERLMEEDGVLGARVLDWDTVRDTAVWYADEKTAQHRFDGKAIGTFDKTKVPTWDLLDDVELEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJE2</accession>
    <name>N1QJE2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_149759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760046.1">
        <property type="nucleotide sequence ID" value="XM_016905754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJE2"/>
    <dbReference type="STRING" id="692275.N1QJE2"/>
    <dbReference type="GeneID" id="27902891"/>
    <dbReference type="eggNOG" id="KOG1672">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072378_1_0_1"/>
    <dbReference type="OMA" id="KEFMNIT"/>
    <dbReference type="OrthoDB" id="10257948at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02989">
        <property type="entry name" value="Phd_like_TxnDC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21148">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF11925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="153" mass="17853" checksum="0C56539A7AF4A7DD" modified="2013-06-26" version="1">MKETSHGTYCEIKSEESLMEISTSEKLCIIHFMKPDFNRCGYMDSKLAILAEKHFDTRFVSINVENAPFLVVKLGIKVLPCVIAFKDGVSVDRLIGFEGIGYKPDEFTTKELEERLLQSGVLVRNKMNDDDDRRRARREQEERERDELWDEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJU4</accession>
    <name>N1QJU4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_145779</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764673.1">
        <property type="nucleotide sequence ID" value="XM_016903263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJU4"/>
    <dbReference type="STRING" id="692275.N1QJU4"/>
    <dbReference type="GeneID" id="27900400"/>
    <dbReference type="eggNOG" id="KOG2171">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003794_1_1_1"/>
    <dbReference type="OMA" id="ANACGCV"/>
    <dbReference type="OrthoDB" id="7862313at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057672">
        <property type="entry name" value="TPR_IPO4/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25780">
        <property type="entry name" value="TPR_IPO5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="9">
        <location>
            <begin position="23"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="8">
        <location>
            <begin position="385"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF16552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1106" mass="122608" checksum="6802CAC80AB18BD5" modified="2013-06-26" version="1">MDAQFVSLLQALLEPDTAKVKSATSQLNQNFYKQPESVVALLNIVINHPQPELRQLASVEVRKLVGKHWNAINEAQKPQLRTQLLQSTTDEQQQLARHSKARVIAAIAKVDLEDGQWADLPAILQQAATSSTARHREVGVYIIYTLLETMPDVFQENLAQMLTLFNRTIQDPESVDVRVNTMLALSELAMVLDTEEDTASLKSFQATVPHMVKVLQSTIQEEDEEHTMQAFDVFNKLLSYESAFLNAHFGELLQFFMQVSAKSEIDDEVRSQAISFLMQAVRYRKLKVQSLKVGEHMTKMCLQIATELDEQPDEDDEISPARSALGLLDILSESLPPSQVAVPLLKAIGPFVQDSRPEYRRAGILALGMCVEGAPDFIATQLKEILPLVLHLLEDPATTVRSAALNGVSRLADDLAEDMGKEHAKLIPALIRNFDMALQGMRNSPKDSEEHDLNTHIVKASAMAVDSLIEGLEAEDAAKYVNELMPRFAMLLEHDDHKVQMAAVSAIGSIASASEGAFQPYFEQTMQTLGKYIEIKASEEELELRSMVIDSLGKIASAVGPEAFQQFVRPLMHASEEGLHLDNQRLKETSFILWSTLARVYEENFEPFLDGVVNSLFACLDQEETDAEIQLGAEASDLIGQEITIAGKKIKVAGANGHNEGDIDDIDEDELIKAMEEAEDDDDDDWDDLGAVTAVAMEKEIAVEVLGDVLTHSKGKFLPYMQKTIETTLPLLEHTFEGVRKSAISTLWRAFACLWGLAEDGGMQKWQPGVPLKVKPTADLEKLGDLVMRGTLSVWEEELDRATVTEINRNLAATLKLCGPAVLAPPTNPSQSTPLEQVTAAVMLILQRSHPCQKDEDEIDEPAVLEGESAEYDWLVIETAMEVVTALATALGPQFSELWKIFESPIVKYCSSQERFERSAAVGTMGECIEAMGAGCTPYTSRMFKLLLKRLSDEDPEAKSNAAYGMGLLCLHSTDAKEILPNYNTILGLLEPLLHKNNGASESEARLLDNAAGCVSRMIKKSPDSVPLDQALPHLVDLLPLKEDFRENEPVFDMIISLYQAQNPVIQSLTSKLLPIFEQVQQPPEDQISEDIRNKLTELTQYIRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJY5</accession>
    <name>N1QJY5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_146533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765667.1">
        <property type="nucleotide sequence ID" value="XM_016903713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJY5"/>
    <dbReference type="GeneID" id="27900850"/>
    <dbReference type="eggNOG" id="ENOG502SD6I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1061867_0_0_1"/>
    <dbReference type="OMA" id="KHRKWRE"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF17546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="284" mass="31642" checksum="B10EA346813F9F24" modified="2013-06-26" version="1">MAAAEYFGTQSHPPGPQPGPSSYNGNSNAHNPPYPLSDAPPPYSAFGDPRRHSQPPPLDRPVALPDSAIYRPAPAPVNNGYPPEKSSRPQNQMGDYNRHQPQQQQYGGYQQPQQPNYPQQQQQPHLGSYYPPQDGSAYYRDDQKPPTTPSYNPSHSPYRESKRDRSRSRSRSRGDRYRQHHHHHHHHNDRPQLPKKKSSGASTFLGAGGGAIIGDAIFPGLGTLGGALLGGIGGHEYGKKKRASSNPTSGGGRRHRSYSNDDFDYGSHEYRRDDDYHNNRRGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJZ2</accession>
    <name>N1QJZ2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_146518</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765641.1">
        <property type="nucleotide sequence ID" value="XM_016903702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJZ2"/>
    <dbReference type="STRING" id="692275.N1QJZ2"/>
    <dbReference type="GeneID" id="27900839"/>
    <dbReference type="eggNOG" id="ENOG502S0PN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061830_1_0_1"/>
    <dbReference type="OMA" id="WIHIWIA"/>
    <dbReference type="OrthoDB" id="5397827at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF17520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="267" mass="30515" checksum="B4E9964279E81831" modified="2013-06-26" version="1">MASLRLAVPRAGFSLHSRQLQHLRILPAVRHASTDKPTPPKPRVLEKPDKFRPPSHPARLRSKTRYTYGPDLTPTQRTRRYPHMMPPEGTFMHWFLTNRVIHLWISLGILVSLVIGVWISDFLHNTPYYDMLPPRSMFFSHPIAYISRWLETYNLHVAFVTAQTAEKRRQKVDDVRKRSEYRKAHGLDQAEGGLFGGWSAKGDDESMGPALREDNVRLAGQQGLGANTNLGEESKNTVVGQAGESKETYVDFEGKQQPVQKKWFGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>N1QK05</accession>
    <name>N1QK05_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AMP deaminase</fullName>
            <ecNumber evidence="4">3.5.4.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Myoadenylate deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_145824</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from AMP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.6" evidence="4"/>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764728.1">
        <property type="nucleotide sequence ID" value="XM_016903288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QK05"/>
    <dbReference type="STRING" id="692275.N1QK05"/>
    <dbReference type="GeneID" id="27900425"/>
    <dbReference type="eggNOG" id="KOG1096">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003782_0_0_1"/>
    <dbReference type="OMA" id="WLYFMFA"/>
    <dbReference type="OrthoDB" id="1723809at2759"/>
    <dbReference type="UniPathway" id="UPA00591">
        <property type="reaction ID" value="UER00663"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003876">
        <property type="term" value="F:AMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01319">
        <property type="entry name" value="AMPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.800.20:FF:000001">
        <property type="entry name" value="AMP deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000214">
        <property type="entry name" value="AMP deaminase Amd1, putative (AFU_orthologue AFUA_8G02860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000300">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006650">
        <property type="entry name" value="A/AMP_deam_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006329">
        <property type="entry name" value="AMPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01429">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359:SF0">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19326">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00485">
        <property type="entry name" value="A_DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="147"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="294"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="921"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="991"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="154"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="320"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="941"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1003"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1021"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1071"/>
            <end position="1083"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00078830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF16607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1108" mass="123953" checksum="E07A73FC757BC359" modified="2013-06-26" version="1">MQRNTMSFHGQHSDDSDLDDDEVASSEGVNSEAGEPSEPSQHPENSSKGLPSNTSADRDSHASAEPTTAAAAAADEEASEPEGTLLRDKQRRTAHYNYQLEKQMSHVEAKQFYQQQRQNTLDEHALSASPVMGSSPILRARTYSGHFGGDASSLRRSGSVKSKQSTSTLREPAQSAYRSALPVGLSDPRKHPDSSTIQSPSIGRFEGLNGIRSTHAAEDESLLEADRAAQAHSLHPGLPHETKPLLEQVGIHGAGAGIGQDAVNDANVTSELSAIYSNLQKILDLRHKYIRLSLQGPTDNPRDEPGWELYPPPPEPVWYENKERNASSEKDGKSPATSSSKPKKPQRKMGQDIGEDFDLEDCLPVPEASEMTYKLDQNGVYQVYETRTSAELGEPILHIPDIREYYMDLDSILAISSDGPSKSFAYRRLQYLEGKFNLYVLLNEYQEVADTKAVPHRDFYNVRKVDTHVHHSACMNQKHLLRFIKSKMKKSPDEVVLFRDGEYLTLKQVFESINLTAYDLSIDTLDMHAHTDSFHRFDKFNLKYNPVGESRLRTIFLKTDNHIQGRYLAELTKEVIADLESSKYQMVEWRISIYGRSPDEWEKLAAWVVDNKLYSPNVRWLIQVPRLYDVYKAAKTMESFEQVLKNVFEPLFEVTQDPSKHPKLHVFLQRVIGFDSVDDESKTERRIYRKFPLPKDWNTKQNPPYTYWIYYLFANIASLNVWRKQRGFNTFVLRPHCGEAGDTDHLAAAVLCCHSISHGLLLRKVPLLQYIFYLEQIGVAMSPLSNNALFLAYERNPFLQYFRRGLNVSLSTDDPLQFAFTKEPLIEEYAVAAQIYKLSAVDMSELAKHSVIQSGFEHVMKQRWLGNNYHLPGVAGNDMAKVNVPNIREAFRHETWLQELAMIDRYTNALAGDSLSAKALAPGQQTIPPSPTPSMMTHPSATNPIHSNDASTYRSGAYATSNAIGAPRSYQPNAQAARLSQIDLGQAQLVDGTSGPRARRSMNHMSESPHQGPPQLQTEVSSASASTLLGSGTLAGHEPKMFPGVMSRHRKSSVPPAGVVDDSGDGGLERSTGSLSRSMTMSTVEDERKGMMETTEEAEEPHGSEKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1QL64</accession>
    <name>N1QL64_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNase I-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_149763</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760052.1">
        <property type="nucleotide sequence ID" value="XM_016905757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QL64"/>
    <dbReference type="STRING" id="692275.N1QL64"/>
    <dbReference type="GeneID" id="27902894"/>
    <dbReference type="eggNOG" id="KOG0565">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002027_1_1_1"/>
    <dbReference type="OMA" id="CVFVKHK"/>
    <dbReference type="OrthoDB" id="2248459at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000036">
        <property type="entry name" value="Inositol polyphosphate phosphatase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF240">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE 5-PHOSPHATASE C9G1.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="2">
        <location>
            <begin position="877"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="257"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="464"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF11931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1272" mass="140559" checksum="632FA13406B1B9EF" modified="2013-06-26" version="1">MDGKQDGPDTTSIKPMSSLRAKFESMAKEQPDTAPVTPVGAKPAALLGVRGTSPTARLGTTDGGRRSVDMGVRSTPSGQSLLAPSPTSQRSHTPGGTAGVRPASMVSLTPTKPSPPTVKVNSPRSPHKTFSLDLRPAASGTLMAPLLAPLTPDRTGDSAGKGHARNISRTTTPALEARMGAFLQAADTPKTPGAEDMAPPPLPDNKPKSDAKSDSTPGPPSFNRAAKPKVPVKPPVLAKKPSNLSPHEPGSDFADKTPSPFTTPPSSGSSSPRLNLASTSQQPARGGLHTSAVNRIRADSNASWVQRVRGDSDASLTGRARAESNTSTASFVEPSSLPDDWFPHSNRPSSRDHEPRHLQRAPTMPARYTGMNGRGARSTENLGEDVPRLPTRPELQSRTGRVSPPKPRSGRTSPLKTQMLPPRRSVDGLRRAASRTGPEAAPRIPAVPTTRINTKSALSQGFGSAASSPATATPTRPPAIPAPRRSVDNRRSLDRRREPPPPLSAVNGKSHDDQEEVIPYASSEQGVALSDYPDGTRANRRAPKFKQRPWHIPTEYDTRLFAVCGEYVCTTGYITKVWNFTTGEQLLHMEHRDNTKVTSIVFKPSPDVQHEGDRIWIGTNAGDIHEIDVPSQQVVKSKIAAHNRREVIRMYRYASELWTLDDGGELLVWKPDPKGMPSLDSQYNNWRVPKGHSFSIACGKQLWIATGKEIRVFAPSALSDTEYQLTRSPLSQPGTGDVTAGATLNHRQELIYFGHSDGKVSIYNRRDFSCQAVVNVSVYRISCMAGVGEYLWAGYSTGMAYVYDTSTTPWMIRKDWKAHEKQMCSIVADSSAMWKIGRLNVVTLGLDNFLRIWDGMLQDDWLEARMQVRDSEFCRFRELTAAVLTWNAGACKPGHLQHSPEDNTFFRDYLTAREPPDIFIFGFQELVDLEDKKVTAKSFFKSKKKEPDEQQHMSSQYRAWRDYLGKSLDDFMPASASYTLVHTASMVGLFTCIFVKSTERPRIRNIHASEVKRGMGGHHGNKGAIIVRMVLDDSSICMVNCHLAAGQTQTMHRNNDIAEILEANTLPSYPLHDGEVAQHSDVFASGGDGSMVMDHEICILNGDLNYRIDTMGRDSVIKHVQQGNLARLLERDQLLLSRRKNPGFRLRAFQENQIKFAPTYKYNVHTDQYDTSEKRRAPAWCDRILYRGLGRVKMDEYRRWDQIRVSDHRPVSGRLQLRVKTVDPDKREIVWDKCRKEYESVQQRIARAAQLEYLTNTLGLTPKEAVAALQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1QL75</accession>
    <name>N1QL75_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Complex 1 LYR protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_146839</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016766056.1">
        <property type="nucleotide sequence ID" value="XM_016903900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QL75"/>
    <dbReference type="STRING" id="692275.N1QL75"/>
    <dbReference type="GeneID" id="27901037"/>
    <dbReference type="eggNOG" id="ENOG502S4VH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_662442_0_0_1"/>
    <dbReference type="OMA" id="KKSTQHR"/>
    <dbReference type="OrthoDB" id="3925971at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20273">
        <property type="entry name" value="Complex1_LYR_unchar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046896">
        <property type="entry name" value="Cup1-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF17935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="360" mass="40887" checksum="F6161D666CF740BA" modified="2013-06-26" version="1">MPKFLVAHRSGAHRLAAIALYRALVSQCTQLDIPAERGRQLLHLVRHRFDSFRHTTSHRELKLLFEAGYEAVDRLDAAVAGDKKSKQYILDLVCRAPHSAAGRIKSRNSVSDDYNEPFPPPVAAEGTAPSDPLLCQPEIAPRDTSPSRTSIFERAIPHDQLGGTGKRQIPKIFSANVIPVLRFKKPQSPALTGYLNSRIEQRQKRHNLRHRLEAELQVASLEDQWDDIMYKQSGIEGGSAEHAPAAVAKAGNNNNFFTPPEPRWTREIASELRIVSKRLDDEKVKNRAMAEKMYKVIDREMVLLAQEQEQERLAEEARKQEIRDGLEGLTDMVGEICDADDDYHHWEKPAQQESYTYRPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1QLC3</accession>
    <name>N1QLC3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_137809</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765203.1">
        <property type="nucleotide sequence ID" value="XM_016902854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QLC3"/>
    <dbReference type="STRING" id="692275.N1QLC3"/>
    <dbReference type="GeneID" id="27899991"/>
    <dbReference type="eggNOG" id="ENOG502SUG4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107220_1_1_1"/>
    <dbReference type="OMA" id="YPQRYAW"/>
    <dbReference type="OrthoDB" id="10264449at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF17082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="148" mass="15798" checksum="DAECFCC4BBBD49B3" modified="2013-06-26" version="1">MAPYPTAAEIRGFASSLGTSDPSPFFDRVSPQVEWHVMGTHPAAGVFTSLDAWKKGALGVVNAVLKEPLALEVVNVFGGGDQEWATVELKADSVCLNGMPYPQRYAWLLRFDKSGTIVQTKAYLDSALVQKAVSSNSGEGGSGLPKWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1QLC7</accession>
    <name>N1QLC7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RING finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_146876</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016766116.1">
        <property type="nucleotide sequence ID" value="XM_016903929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QLC7"/>
    <dbReference type="STRING" id="692275.N1QLC7"/>
    <dbReference type="GeneID" id="27901066"/>
    <dbReference type="eggNOG" id="ENOG502S6DH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047453_0_0_1"/>
    <dbReference type="OMA" id="CLQSWRH"/>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16495">
        <property type="entry name" value="RING_CH-C4HC3_MARCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46347">
        <property type="entry name" value="RING/FYVE/PHD ZINC FINGER SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46347:SF1">
        <property type="entry name" value="RING_FYVE_PHD ZINC FINGER SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="6">
        <location>
            <begin position="58"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="309"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF17995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="320" mass="36036" checksum="CD48F886EA887996" modified="2013-06-26" version="1">MAAYTTGASWSFPQDLPGAFDGPTWDGSASHSSTPPHTEAYAESAPEFSEEHRPKRPRRHYPTRKCRICLEDVQPTFHADSESTLPAAMQPSPRVTYESEDGGRLLSPCKCKGSQKYVHEECLSAWRRADPTQKRNYWECPTCRYRYKLQRLTWSSWISSTAAQLALTLLIIISSVFLLGFVADPIINMYIDPYTTIATAGGPRDSLIWEDEPTTWFEHMLKGIASLGLVGFAKFLFTLSPFQWFNLRSVGGRTSMGGNGRDRLQQISWITVMIGVVTASYAIWKLVRAWSRRTLESAGERVMDVPGSTDEDEDEDDEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1QM21</accession>
    <name>N1QM21_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_146033</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765024.1">
        <property type="nucleotide sequence ID" value="XM_016903411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QM21"/>
    <dbReference type="STRING" id="692275.N1QM21"/>
    <dbReference type="GeneID" id="27900548"/>
    <dbReference type="eggNOG" id="ENOG502QPY2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011075_0_0_1"/>
    <dbReference type="OMA" id="TAQAYRW"/>
    <dbReference type="OrthoDB" id="3886144at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF47">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="88"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="135"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="152"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="199"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF16903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="870" mass="95941" checksum="8FD86B77DA7A0AE7" modified="2013-06-26" version="1">MADGSPLPFPSPSVILSEDTSPVNPPQPAEQPARRSKHARSLSKKDGVKKAVPKKTAAAAAAAEVDAGPDAVKGAKVDKPKQTKSRNGCSTCKAKRLKCGEEKPGCMNCSKRGVVCGGYKKVFQWRDYGGHQIKSSITSQKQATSRVSPTQEASALSSLSTTPTAEPPNILDKPLSDPHEAQMPRRKAPRRGFKHENELIQSQDPQRGSNLLSSDYHSRADSGFVPAEDLELSPESQQTIENASPDDGNANGQPILFNPESAFVYRTRSLSPVHGRGPSPTLTEMMLQDGHNLNASQADFVPFSMPENFQLPLFSAGTNDPIMQEHGIFNDIDLIGPIQPIDMDTFMWPSRLQTPGPQGSSPNCIDFNGMWNGTGSNLWGQPDLPFDSEDMLMDRFNQQTCGVLSVIDGPTENPWRRLIMPLAKQSTGLHHALLALAAFHGAQDTPSLVYVGAHHKTVAMQNIREGLRDNTMLNHAAIATALALGFVEAWESHVKTGNAHINGAAALVKKALDDHHRTPHVGEDLARLKFLCNAWVYMDVIARVTAVDANDSIDFKYALWPPNETPELAIGHSAPGFGINLGMGIDARLDPLMGCAGTLFPLIGHVANLVRKVCRSQRNPIGIISQARDLMESLEQWEPPAYIERPEDPLTDVRHALQTAEAYRYATMLHLHQSVPELPTPLTDEQYAQRVLQYLATVPLNSRMLLVHIYPLMIAGCQAIESEDRDWIRQRWEIMGSLMRIGIIDKCVALSEEVWRRRDSYEATPPEKRRLVATADLHQVRDRDTPLERTAAEVRMSEPGRRGMVFSLMDLDGNLSSPGGADGSGRLDKRQLRDRNPEMALGKIDMAYTVRGHISWVGVMWDWKWEVLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1QM80</accession>
    <name>N1QM80_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">PIG-F-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_146110</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765114.1">
        <property type="nucleotide sequence ID" value="XM_016903459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QM80"/>
    <dbReference type="STRING" id="692275.N1QM80"/>
    <dbReference type="GeneID" id="27900596"/>
    <dbReference type="eggNOG" id="KOG3144">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069429_1_0_1"/>
    <dbReference type="OMA" id="WQRWPVT"/>
    <dbReference type="OrthoDB" id="17366at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009580">
        <property type="entry name" value="GPI_biosynthesis_protein_Pig-F"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06699">
        <property type="entry name" value="PIG-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="74"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="99"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF16993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="254" mass="26908" checksum="5C309546BF67A47B" modified="2013-06-26" version="1">MASPPLPAGKVVEVLDTSTSRVYAHLHTLLLLAIVPVSWSSLVAAPVSTLLHLAPTTLVLQALYCAVCLPQTGQPTTSTTTTTATATTTTTTTPSPPHSKPKPPRPNKSGHNKTARAVTATALLSLVLTFFLAAPLLCIIALLFGAPLVSHQPHTALLAVHLALLTTPHLFYVHGLDATAWLRLASLQQPYDEVYGLSLGACAGAWLGAIPIPLDWDREWQKWPVTIVCGMYAGAVVGKLAGGYLLKGFKMKML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1QMG6</accession>
    <name>N1QMG6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Inosine-uridine preferring nucleoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_146525</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the IUNH family.</text>
    </comment>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:purine nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023186">
        <property type="entry name" value="IUNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304:SF56">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G11790)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304">
        <property type="entry name" value="INOSINE-URIDINE PREFERRING NUCLEOSIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IU_nuc_hydro"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inosine/uridine-preferring nucleoside hydrolase" evidence="5">
        <location>
            <begin position="5"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="394"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF17532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="445" mass="49067" checksum="12DDC6E465EA08F4" modified="2013-06-26" version="1">MARKIIIDTDPGVDDVLAMLLALSALPEELEVLLLSVTYGNIDVQNCLRNVVSMFFHIEKEIEWRQAQGKPLGFDALRKTKPIVAVGSEHPLTDQMLMADFFHGRDGLGGIHGTHPHMTPDETWKSLFEKASSSSADADKEIATELRSEHAMFTASKASAVDEMLRLLRENEADTITIVAVGPLTNLAHAAALDPETFLKAKEIVVMGGNVTEIGNMTPVAEFNTFADSVAAARVYALTSPTPKTTMPPTPPTPVAPSHTDQAPPYLADYPEHLSRQLTVSLFPLDITNRHEITRGLFRTLSEPLIQSGSPLAHWVSAFLHSTFDKVESLQQDVVGDAVGLQLHDPLCIWYCMAADHASSQWHLKQDEDLRVETSGQWTRGMCVVDRRTRKKRPEGDEGERPGDSGNWLSLRGGNRIRICTGTPQTVEQQGQHFGEVLVKRIFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1QMR2</accession>
    <name>N1QMR2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_146366</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016903605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QMR2"/>
    <dbReference type="STRING" id="692275.N1QMR2"/>
    <dbReference type="GeneID" id="27900742"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_274183_0_0_1"/>
    <dbReference type="OMA" id="PLHFSGE"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="377"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="410"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="625"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1145"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="733"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="798"/>
            <end position="900"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF17308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1170" mass="129986" checksum="405FB00CA1660E10" modified="2013-06-26" version="1">MNGSKSPDPANTKTGPAAQNDRRTEHANGNRELNQRDDIREANDGLAAVGAPTREEPAALDAGTLKEAQEKAENDAPHDDVDSEAETLIDSPVKRKEAERQTNAVKLERQQPKPRHRIGSLPVPTDGDEDDSAQPSPVPSVENAASAKDVKDESLEHTKDDGDRNSMSEPLSSPRSSASNPPSRESSLARAVSELPEYSSNIALSPNPRKRKHRASSVSLPNKRPSNEPSRRRIRGLHSEELDARKESSLSPKLRSHRRAASTQSAFTEGVPEVPDKKRRSAPHGLGKELKSGRPLWEESDTSSETTSHGNTESRRPRRGVGRSTSTPGRPAGREHKRHINKYGFTRLAEACEEGDLDRVKEWRNRDPDQLELAEFAGNKPLQIAALHGNVEVVDYLIEQGCQIDCANVDKDTPLIDAAENGHLDVLRSLLRAGVDPLRQNLKGQQALDVVTDDTDDADEIRAALRSAIEVWNTNGSRQRREEEEEMRHRAGPTKELHFMARSYENLLKLVQINDRNGVKEFLDARVPVDNAIIAAAAKTGDSYLVNMLLAEMSEKKASQRPERLMLSVLGTSHLEMVKSLSELDNFDPLYRNRQDKTWPELAEERHGPNWREEKLLLQRLYDQSAASKERCSSSPVSKRDSAKRRVVRRTPAGDEAGGEGGGEDSDEDQAPRRKNGRRLMSKRDMRVASGRAPSHESSDASSSDDATGTGNEREEGASTKTPSNAADVRGSGSKNRTSSSTTPNVDTSPRLRRQSSSLRATTERPLQPLEEVAEDKDTAAPSETSEMHAANEAQLAEMKRIQDREAEAAAAAERAEAERARLAEEERRAEQARREEEARAAEEQRRAEEQRRAEEQRRAEEQRKAEEQRRAEEQRRAEEQRRAEEQRKAEEERRAEEERARVKQEMAATKLRYLERVAISLPIAISHVLHPASAFSFDSDAALDYLIQYFTPLQVLKQEHQDASATLPAGADAPHWITNMQAAPLVGKQGIELMLPKSAPGYEASLANAWATKDVLDTDQDLIGSVLASLPQHLPPGQVLDSDLHSRLSFEEDVQRAADRINAVAEMRARLRDGEAVLRYVRLDEVMKNLHPKLRDLPIDVRYDYMPVSIPSRGMSQVDSGNFVTNLNASMDARPRQQTFVDGEGVNGVSSPPRRLTPVSIAHQKSGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1QMT6</accession>
    <name>N1QMT6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_58356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765813.1">
        <property type="nucleotide sequence ID" value="XM_016909464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QMT6"/>
    <dbReference type="STRING" id="692275.N1QMT6"/>
    <dbReference type="GeneID" id="27906601"/>
    <dbReference type="eggNOG" id="ENOG502QUIU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_655737_0_0_1"/>
    <dbReference type="OMA" id="NNKHGQT"/>
    <dbReference type="OrthoDB" id="438641at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF251">
        <property type="entry name" value="EG:BACR7C10.4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="204"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF17692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="517" mass="58799" checksum="351DA410CA10A691" modified="2013-06-26" version="1">MEQPFSASEWKPTKVSEPWDKPLPKADLEELIVRLATDQREIRLHPYDPRRWIRRAHTFTLLRYPELAVGDACKASLLCKSLLKVLNQNLKPNYRLGAHAGFWMGHGEREDGDGDEDEDDEVAERMEKLDIDSEHLTHRVRFLQIQSAADKVIMDNLAYAPNAEEGMFYPRPYPWMKAEHSTRSDEILQQVNWELAHPLVTPLPALFAKRYAFGKGVGTRGGAESFGLFALRDIEKGEKLIVDRSRIWGCIGPGSGDSRDYDHDGLPAGGRASNLDGGYGCANFMHPNQVGDKVEHDLRWIRDRLGKDAAHTILLARFFLTCIRDRIDHPLSHPLIARLTPSYRTTAYKSFCLEKDITILMEVLQNFGVDIFANHNFDTWVLFEIHARVINNSWSDPLATCVSPLFSLINHSCEPNLSWNTVEGHSTLHVVANTHVDKDEQVFVEYDQFQHEKPLRVRRKRLEDWFDADCQCTRCVREELEEKAAGEGDGGGGLLWGPGKPVWDLGVVVELPEDGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1QN45</accession>
    <name>N1QN45_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_22546</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765150.1">
        <property type="nucleotide sequence ID" value="XM_016908357.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QN45"/>
    <dbReference type="STRING" id="692275.N1QN45"/>
    <dbReference type="GeneID" id="27905494"/>
    <dbReference type="eggNOG" id="ENOG502S287">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090404_1_1_1"/>
    <dbReference type="OMA" id="PIPWRFS"/>
    <dbReference type="OrthoDB" id="73901at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF120">
        <property type="entry name" value="HIGH-AFFINITY COPPER TRANSPORTER CTRA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0187">Copper transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF17029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="190" mass="20941" checksum="447C9634DA44EF38" modified="2013-06-26" version="1" fragment="single">MSSMTHSMSMVFTTDHSTALYASAWTPRTTGAYAGTCIFLIVLGIISRLLLAFRQVLEAKWHDKAVNRRYVVAAGEAGQLDNNNNNNNNNATSPTAAADEKSDYATLTTRGLDENVRVLRTPRQHTSLPAWRFSTDLPRACIFTVQAFVGYLLMLAVMTLNVGYFMSSLAGLFLGELAVGRYNIMDDGHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNQ6</accession>
    <name>N1QNQ6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_105146</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016766094.1">
        <property type="nucleotide sequence ID" value="XM_016900566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNQ6"/>
    <dbReference type="GeneID" id="27897703"/>
    <dbReference type="eggNOG" id="ENOG502R8YN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086117_0_0_1"/>
    <dbReference type="OMA" id="FNFFRVD"/>
    <dbReference type="OrthoDB" id="2951834at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF17973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="29079" checksum="AB78C6EA94F89866" modified="2013-06-26" version="1">MTSPTPPNQHQPCCHLFRLPLELRQHIYSFLIPAETNFTPIPAAGINSVNYRPPSLSLLTIHPTITAEILNDFYSLSTWKIVCGHSYNYFRIDPELMHLERSRCLARMEKVEMMFFVDGEFILDYPSFGIPRLCTEIAKRAHRACQVLLQAPELRIIVVSWWDTTTTTTTTTSAAKADSRGGGGEEWRSNVLAPLRILVDGKEEEEKKKNSSSYSKRRLRFEVGSVNSAEEFGREEFAGALRGVIGEGMVEVRNLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M3ARJ0</accession>
    <name>M3ARJ0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_54634</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF08104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756225.1">
        <property type="nucleotide sequence ID" value="XM_016909310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3ARJ0"/>
    <dbReference type="GeneID" id="27906447"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_4_2_1"/>
    <dbReference type="OMA" id="KWLDQAN"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF39">
        <property type="entry name" value="TRANSPORTER LIZ1_SEO1, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="43"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF08104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="490" mass="55131" checksum="C8831067F4C2F454" modified="2013-05-01" version="1">MELVRTAFASSYHGTDKPKFFWWYPKGTSLAEKKLLTKIDFFILSYCCLGYFAKWLDQANLSNAYVSGMKEDLDMYGNELNLATTLFNIGSILGGIPSNLLITYVPPRYILPGCELLWGIITVFTYKVTTAQQLYPLRFFLGLLEGTSFVGIQYVLGSWYKRTELGKRTAIFACSAYVGTAFGGYIFSGVYASMNGSGGLAAWRWAFVVDGVITVVIALYGLAFFPDTPEKTTAFYLSSAERERCVERLVEEDRRPTGGWSWDVCGRIFGSWQFYLLTVLWMFWQTTVGKVGNTVFQLYLKNDTARNWSVYQINNIPTAINGFNIVMVMLVNIYADATGRRMVAAVFSLSILCFGTICLVAWDIPLGLRVVAYLFAACDGPLSPLYMAWANILCGSDKQVRAMTIAMMNALGNATTTIIQQFAYPVTSAPEYRVGFRTSLGLICGMYVWVFVVRYFELRAEKRRMSASEILEGSSWESKEVQPVIRKMDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>M3AS26</accession>
    <name>M3AS26_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_152007</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756435.1">
        <property type="nucleotide sequence ID" value="XM_016907184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AS26"/>
    <dbReference type="GeneID" id="27904321"/>
    <dbReference type="HOGENOM" id="CLU_2514073_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF08314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="85" mass="9624" checksum="1770548913B483AC" modified="2013-05-01" version="1">MRNLQEGVGVGLGKLTKYLRYLREGVWELLVPSLASVGKRYGFDDKFADISLDLPLPYSTDDYSQFWQWLSSLGLISNNGVYSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M3AU65</accession>
    <name>M3AU65_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">dihydrolipoyllysine-residue succinyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">2-oxoglutarate dehydrogenase complex component E2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SEPMUDRAFT_151884</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 6/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.61" evidence="5"/>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF09029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757150.1">
        <property type="nucleotide sequence ID" value="XM_016907101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AU65"/>
    <dbReference type="STRING" id="692275.M3AU65"/>
    <dbReference type="GeneID" id="27904238"/>
    <dbReference type="eggNOG" id="KOG0559">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016733_0_1_1"/>
    <dbReference type="OMA" id="NMPQTAV"/>
    <dbReference type="OrthoDB" id="5391403at2759"/>
    <dbReference type="UniPathway" id="UPA00868">
        <property type="reaction ID" value="UER00840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004149">
        <property type="term" value="F:dihydrolipoyllysine-residue succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033512">
        <property type="term" value="P:L-lysine catabolic process to acetyl-CoA via saccharopine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000006">
        <property type="entry name" value="Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050537">
        <property type="entry name" value="2-oxoacid_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006255">
        <property type="entry name" value="SucB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004309">
        <property type="entry name" value="PRK05704.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01347">
        <property type="entry name" value="sucB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416:SF5">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="14">
        <location>
            <begin position="80"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="152"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="160"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="199"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMF09029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="473" mass="51919" checksum="2FCA824B10FA2098" modified="2013-05-01" version="1">MSSSQCLRRLARSSPRPNTLRQPLATTSRAAQSYTATRYLSSSSSSSAPSISLRPLQQSQKLFSPLQLRQFSLSTQRWEEQVVKVPEMAESISEGTLKQFSKQVGDYVELDEEIATIETDKIDVAVNAPAAGTIKEFLANEEDTVTVGQDLVRLELGGEPGEKKETAKSEPKEAASGDQKTPPSQEGSPQNAESQQPKSESKPEPKKEEPKPEPKKETKPAPKKEEPKKEQTESPYGTRSENRVKMNRMRLRIAERLKQSQNTAASLTTFNEVDMSQLMDLRKNYKDEILKKTGVKLGFMSAFSKAAVLAMKDVPTVNAAIEGPGGGDTIVYKDYVDISVAVATEKGLVTPVVRNAESLDMVGIEKAIADLGKKARDNKLTIEDMAGGTFTISNGGVFGSMFGTPIINLPQTAVLGLHAIKDKPVAVNGKVEIRPMMYLALTYDHRLLDGREAVTFLVKIKEYIEDPRKMLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M3AWD8</accession>
    <name>M3AWD8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial import inner membrane translocase subunit TIM16</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Mitochondrial import inner membrane translocase subunit tim16</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 12">Presequence translocated-associated motor subunit PAM16</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SEPMUDRAFT_126665</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIM16/PAM16 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759181.1">
        <property type="nucleotide sequence ID" value="XM_016902091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AWD8"/>
    <dbReference type="STRING" id="692275.M3AWD8"/>
    <dbReference type="GeneID" id="27899228"/>
    <dbReference type="eggNOG" id="KOG3442">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101461_0_1_1"/>
    <dbReference type="OMA" id="AKYLIQI"/>
    <dbReference type="OrthoDB" id="10262892at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000006">
        <property type="entry name" value="Import inner membrane translocase subunit TIM16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005341">
        <property type="entry name" value="Tim16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12388">
        <property type="entry name" value="MITOCHONDRIA ASSOCIATED GRANULOCYTE MACROPHAGE CSF SIGNALING MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12388:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03656">
        <property type="entry name" value="Pam16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMF11060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="137" mass="15532" checksum="7378C465D69993C1" modified="2013-05-01" version="1">MAHRIVTQVLVTGARVFGRAFGEAYKQASASQKYQQAMQGNPTASNTLSSAGLTLDEACRILNVPPPKQGQADLTKVHDNFKRLFDINDPKKGGSFYLQSKILRARERLELEVREAQEAAEREEELRRGWQPRIYRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M3AXN6</accession>
    <name>M3AXN6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_150412</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759621.1">
        <property type="nucleotide sequence ID" value="XM_016906157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AXN6"/>
    <dbReference type="STRING" id="692275.M3AXN6"/>
    <dbReference type="GeneID" id="27903294"/>
    <dbReference type="eggNOG" id="KOG1290">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_81_12_1"/>
    <dbReference type="OMA" id="NHKGPNG"/>
    <dbReference type="OrthoDB" id="2649at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14136">
        <property type="entry name" value="STKc_SRPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000409">
        <property type="entry name" value="CMGC/SRPK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000076">
        <property type="entry name" value="CMGC/SRPK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="121"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="276"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="326"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="85"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="276"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="296"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF11500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="616" mass="67643" checksum="20BDB1EA1EA0662A" modified="2013-05-01" version="1">MNNSGEGLKKAAINKAKQSATNANGNGQKRRKQDLKPILTTSEQQQAAGGTTNSAQSNQSPLKHNKAAPQHGKDHHDSPSGSESSGEEGTENTADEEDSEDYCKGGYHPVQVGEQYKDGKYTIVRKLGWGHFSTVWLSKDNTTGKHVALKVVRSAAHYTETALDEIKLLNKVVAANKDHPGRQHVVSLLDSFNHKGPHGMHVCMVFEVLGENLLGLIKRWNHRGIPMPLVKQITKQVLLGLDYLHRECGIIHTDLKPENVLIEIGDVEQIVKTYVKEDPKEKDDHRNGRRRRRTLITGSQPLPSPLNATFSQADLANFPGSTSSLNKIVNESKGNSPITGSSPTAPDGAEMSGALGTESRSMLESLGIKSEGGDGKEGVTQKEREKTAEILANNVSDMDLGGSHAVKPKEMEKADDGIEIISVKIADLGNACWVGHHFTNDIQTRQYRSPEVILGAKWGASTDVWSMACMVFELITGDYLFDPQSGTKYGKDDDHIAQIIELLGTFPKSLCISGKWSQEIFNRKGELRNIHRLRHWALPDVLREKYHFSVEEAKRIGEFLLPMLELQPADRANAGGMANHPFLDETKGMSGVRTNVEVGSKGEGIEGWATEVKKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M3AZ72</accession>
    <name>M3AZ72_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_149379</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760958.1">
        <property type="nucleotide sequence ID" value="XM_016905518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AZ72"/>
    <dbReference type="STRING" id="692275.M3AZ72"/>
    <dbReference type="GeneID" id="27902655"/>
    <dbReference type="eggNOG" id="KOG1278">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010714_4_1_1"/>
    <dbReference type="OMA" id="KVYYMFG"/>
    <dbReference type="OrthoDB" id="1666796at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF111">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007363865" description="Transmembrane 9 superfamily member" evidence="7">
        <location>
            <begin position="23"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="345"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="416"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="453"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="500"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="538"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="576"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="607"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF12837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="646" mass="72643" checksum="5A5D7E3A200F3C64" modified="2013-05-01" version="1">MRLYELPTALLVLVSAAPLAQGFYLPGITPTNYKHGDLVPLTVNHLSPAQSQRDNSVKSAFSFDYYQPNFHFCAPKDGPKRISESLGSILFGDRILTSPFRLRMEVNETCQAVCDEVVFKDADAKFVNRRIQQDYIVNWLIDGLPAAQAYRDPNTDSEFYQPGFVLGDVVNDRPQLNNHYDIWIDYHAVRPNEYRVVGILVEPSSRRDSKRVGKGDDMKADCGKNGGPVILSEKEGAVTKVTWTYSVYWRPSATSFATRWDKYLHVFDPKIHWFSLINSAVIVMFLVGMVSTILVRTLRKDIARYNRLDQIDLDDLNDTSVGDGVHDDSGWKLVHGDVFRPPKHALALSVLVGNGAQLFMMAGFTIVIALVGFLSPSNRGSLATVMILLYTVFGCVGGYAGARVYKFFGGEKWKQLFVLIPSAVPAIVFATFFLLNLFVWARQSSGAVPFTTMLVIVGIWFVISVPSSIAGSWFGFRQPISDAPVHTNQIPRQIPPSQGYLRLVPSMFLVGVLPFGAIFVELYFIMNSLWSNRVYYMFGFLFLSFGLLVVTSAAVTILMIYFLLCQENYHWQWRAFASSGASAGYVFAYSLLYWARMLSFSSFTGSLLYLGYSIVLSFLWFLLSGSIGFFACWIFVHRIYSSLKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M3B083</accession>
    <name>M3B083_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">alpha-amylase</fullName>
            <ecNumber evidence="4">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">SEPMUDRAFT_63901</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 22">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761323.1">
        <property type="nucleotide sequence ID" value="XM_016909657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B083"/>
    <dbReference type="STRING" id="692275.M3B083"/>
    <dbReference type="GeneID" id="27906794"/>
    <dbReference type="eggNOG" id="KOG0471">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006462_7_2_1"/>
    <dbReference type="OMA" id="GFNPVNR"/>
    <dbReference type="OrthoDB" id="204980at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11319">
        <property type="entry name" value="AmyAc_euk_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000120">
        <property type="entry name" value="Alpha-amylase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013777">
        <property type="entry name" value="A-amylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015340">
        <property type="entry name" value="A_amylase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF215">
        <property type="entry name" value="ALPHA-AMYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09260">
        <property type="entry name" value="A_amylase_dom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001024">
        <property type="entry name" value="Alph-amyl_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0732">Signal</keyword>
    <keyword evidence="17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004031076" description="alpha-amylase" evidence="18">
        <location>
            <begin position="23"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="562"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="19">
        <location>
            <begin position="35"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="13">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="14">
        <location>
            <position position="319"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="52"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="172"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="262"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="463"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EMF13202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="586" mass="64784" checksum="BB76B5446D65AD80" modified="2013-05-01" version="1">MKLSLQILALSAVLLYSLNVSAATLDDWRTRTIYQVLTDRFAKADGSTEGSCDVVNGFYCGGTWKGIVDKLDYIQGMHFDALWISPVVAQLQNTTSDGESYTAYWAQDLYSLNSNFGTADELRELIDEVHRRGMYLMLDIVVNHMAFAGPSEKVDYSVLKPFDDQKYYHSYCAVNGNTNETNVEACWLGSNVVSLPDLRTEDDVVRDMLTDWIREMVSNYSIDGLRIDTALNVEPEFFPDFVEASGVFATGETMHGDNSFVCRWADTIGSILNYPIYYVLVRAFGSPTGNINDLVSTIYTTRANCEDPSAFGIFSENHDVERFAEITNDTALAKNVLTFTLMSDGIPIIYQGQEQHMSGANSPHINRAPLWSTGYDTEAALYRHISTLVLARQHFIRVCDKYATRESHVIYQDYHTIAMRKGHGRAQVITVLNNNGESTEDFEIDVKDHKLKHFTEVTEILTCTQLTVGKSGYLKVPMGKGLPKVLFPTKLLAHSGLCGMGHPLPLPSPTLIATTYATTFATTIGGYSTMIATSVTTTAPSTPKRTKLALGAASHSHTTNDALLVLIVAMSTFLASSGAFLYLFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M3B0Y3</accession>
    <name>M3B0Y3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_116447</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761528.1">
        <property type="nucleotide sequence ID" value="XM_016901258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B0Y3"/>
    <dbReference type="STRING" id="692275.M3B0Y3"/>
    <dbReference type="GeneID" id="27898395"/>
    <dbReference type="eggNOG" id="ENOG502SZ3Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_674674_0_0_1"/>
    <dbReference type="OMA" id="IFRRNIM"/>
    <dbReference type="OrthoDB" id="5337308at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF13407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="408" mass="46409" checksum="9A63B48C2CDDEAA6" modified="2013-05-01" version="1">MSDKTPDATFHTTKLQDILHLWHKAVPPHNLTVLLLCETHNPTPLRHGQFDGPSGFPVAKETSRALDEDSNISLRNDAPDEIYRTDAVSATALPFDSSILTRAPHLIRRVQSSRLPPQVVRPATDAVYYRAQVKGHTLMCWMQNPALAGDQAISPWNRFEQLAEWGWTGPQGSNPIRINYSEERDPAMRRLVGSRPRTGMVGQVEHKTTPAHAPVTLDGKTYQYPATMAEYQNIFYPKDGVILAYYNFGPDYFINGLLRHWNSSTMLKPELSRLSDIWWLLWTKICSLSETDPRDLRYIIQKSVINESTQTVLARVLQHWWPAEPEISQGRAPKWPGKLVTRDMAGFDALLGTENIWGVPYLLVQRCAVLGRREVKGIRVYNPDPRTTYYEVNMVVEIGDVEVRVTDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M3B1H8</accession>
    <name>M3B1H8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">NADH-ubiquinone oxidoreductase 29.9 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_148881</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I NDUFA5 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761773.1">
        <property type="nucleotide sequence ID" value="XM_016905203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B1H8"/>
    <dbReference type="STRING" id="692275.M3B1H8"/>
    <dbReference type="GeneID" id="27902340"/>
    <dbReference type="eggNOG" id="ENOG502S4WS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084284_0_0_1"/>
    <dbReference type="OMA" id="WTYFERG"/>
    <dbReference type="OrthoDB" id="286811at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006806">
        <property type="entry name" value="NDUFA5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12653:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12653">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 13 KD-B SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04716">
        <property type="entry name" value="ETC_C1_NDUFA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF13652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="246" mass="27403" checksum="5A795128CE9CBA9C" modified="2013-05-01" version="1">MRSALRLLASVQKGGSHYLEAGAPTGLAGLLTHSSPRTTLLYLYNDTLEKLKQFPEHSVYRQSTEALTKHRMRIVESVKPQGLLEWQQRVLPVVEANKDAFRTIPVTTSDGEKAINIIWKAGAYLGQSDPEDNLEYKGPAPLEGPRHISEREDQARQLSYDQAAHHASIPEIEPEPPLTASQIGEIEEQVGAGLIEEVIQVAEGEVELVKVMLENKVWEDLEEKPAPGQWVGHERADKYTGMTQKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M3B2Q8</accession>
    <name>M3B2Q8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin-like ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_147900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762183.1">
        <property type="nucleotide sequence ID" value="XM_016904586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B2Q8"/>
    <dbReference type="STRING" id="692275.M3B2Q8"/>
    <dbReference type="GeneID" id="27901723"/>
    <dbReference type="eggNOG" id="KOG0676">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023246_0_0_1"/>
    <dbReference type="OMA" id="GDYRGWI"/>
    <dbReference type="OrthoDB" id="337660at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF14062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="520" mass="57320" checksum="5B304F83394038D3" modified="2013-05-01" version="1">MAATASTAAAITTTTTTTSSRPRPSHSALQAGPSPRSPRTPQLGRSISSQFGSPSGFRSDQDDIILYEIGPRSLSAGFAGESRPRCILPFTPDMARRVGDYRQYEPGHASRTRKFRLREEWAASYELYQNDLREVNLGLVEDKLDRALRTAHIDYLQLDSKPRKAAVIIPSLLPTRLLEAVLKVLFGHYTQPPSIALITQPAMCCVSAGLRDGIVIDIGWEETVVTAVGEYKEVAQRRSVRAGKALTREMGNIIEGSVPSEVEVKVTFDEAEDISQRMAWCQQRSPPSNEDSAIVHLPVPGSTSDESFSILFEKLAEPAERVYFASGTQPDDHDDHDLPVHILAYRLLLSLPTDFRALCVSRIMVTGIYGSLPGLKRRLLQEIDHLIKTRGWNPVFNYGSATSHTNPALKERSPNTLHLVPPGSTSPTVPLSPMKMPLQEAIPHMDRVHDDIKDPITQKAERAQAQGRVEPPIKGIVRGVETLGAWPGASLMASLRVKGVYEVERDDFVKSGLKDQGDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M3B5M3</accession>
    <name>M3B5M3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_11021</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763213.1">
        <property type="nucleotide sequence ID" value="XM_016900833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B5M3"/>
    <dbReference type="STRING" id="692275.M3B5M3"/>
    <dbReference type="GeneID" id="27897970"/>
    <dbReference type="eggNOG" id="KOG0926">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001832_0_4_1"/>
    <dbReference type="OMA" id="FCYLDDK"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000637">
        <property type="entry name" value="ATP-dependent RNA helicase DHX37/DHR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF99">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="395"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="599"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="142"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="202"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="225"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="259"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="271"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF15092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1234" mass="137370" checksum="6465854F9FC90683" modified="2013-05-01" version="1" fragment="single">FVPRERKHRKIARQKEANRKNGLSLHEEADQANATEIVPATTSEKDERRRKLKEELVALQPESKASSKKRKRLDKYVETKLKKEENQELLKKLAAHKVDTSLLRSSKQLSRVSDTRREQLQRALKEREAGIKGNYDDILFERRPNIPEAIEDDSEGDDGSVTGAPQTAICVEKPAVTPAVVVSGGGLKRPLELDDSGQPIIARRKRQKKSAAKKPRLVFNPEPAQESDEEDEEDDQASQEGSDVWNGFESDVDQSESQDSDKSEVDRDSSDSDEDESMTDDSGDDDDEEEDEDEDEVMADDKPARVSAFKAWADSQRNEVVGFAPSSIIDNQDAAKAVFKPRETTPDPVAMDLAAASQLTESTYRPASSVVVERDPQVQEARLKLPVVQDEQKIMEAVHHNPVTIVCGATGSGKTTQLPQMLLENGYATKGMVGITQPRRVAATSVADRVKYELGKVYGAQVAHQVRFDSSVGRDTRIKFMTDGILLREISQDFALQKYSAIVIDEAHERSVNTDILIGMLSRIVPLRQDLSREKPEEFVPLKLIIMSATLRVTDFLMNDRLFRKLKPPIVEAEGRQYQVTEHFARKTQRDYVAEMVRKVARGHKKLPPGDILVFLTGQDDIQTVQKRLKEQLTLESASFQLSANRASRDKVINDFMEDDGKGEADDTDSEAEITGLDEVEDDDAEFAVDVESTTATTARVPLKAQILPLYAALSKAQQDQIFVKTPEGVRKIILATNVAETSLTIDGIKYVFDCGRSKEKQYDIETGVQQFVVDWISQASASQRLGRAGRTGPGHCYRLYSSAIYERYFEKHTLPEILRTPIEGTVLQLKNMKVDNVVNFPFPTPPQLEQLAQAERLLKNLGAIDARTGQVTATGKELINYPVNPRFGKMLMLGRHYEVLAYVVALVAGLAVGDIFIPEPQIAKKDGEEEDSDYETRSARKLMDAAAQTMSEKRRQAYGRAREALTYKGDPSDAMKVLTAVVAHAHAEAEGESAAFCEKHFLREKGMTEVQALRRQLHNLTEGLLKEAADRSFRAALRPPSDKEVGRIKQIAAAGYIDQVAVRYDLLPGAVSIGRKPQRAIEVAYRTLQASTTDVDRQASMQEQERQKCVFVHSSSPLARLSPTEMPPYIVYSSLSRAAARTVGATQRTRLHPLTPVTQPQLASLAEGTPLLDIGKPIGKIEELAGGRRQCWVSVALRDPSAMGSTGWPLKAWKVVQVKKGKEWVIEKVLDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M3B6Q0</accession>
    <name>M3B6Q0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Manganese lipoxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_60337</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763593.1">
        <property type="nucleotide sequence ID" value="XM_016909522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B6Q0"/>
    <dbReference type="SMR" id="M3B6Q0"/>
    <dbReference type="STRING" id="692275.M3B6Q0"/>
    <dbReference type="GeneID" id="27906659"/>
    <dbReference type="eggNOG" id="ENOG502QQSP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004282_4_0_1"/>
    <dbReference type="OMA" id="RYSFIKT"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050584">
        <property type="term" value="F:linoleate 11-lipoxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043651">
        <property type="term" value="P:linoleic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034440">
        <property type="term" value="P:lipid oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.245.10">
        <property type="entry name" value="Lipoxygenase-1, Domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000907">
        <property type="entry name" value="LipOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013819">
        <property type="entry name" value="LipOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036226">
        <property type="entry name" value="LipOase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11771">
        <property type="entry name" value="LIPOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00305">
        <property type="entry name" value="Lipoxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48484">
        <property type="entry name" value="Lipoxigenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51393">
        <property type="entry name" value="LIPOXYGENASE_3"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004031371" description="Manganese lipoxygenase" evidence="6">
        <location>
            <begin position="20"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoxygenase" evidence="7">
        <location>
            <begin position="36"/>
            <end position="601"/>
        </location>
    </feature>
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        <location>
            <begin position="26"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00021175"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF15472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="601" mass="65944" checksum="424F3B6B75132794" modified="2013-05-01" version="1">MHIFTLPYVLWLLPAVVSASPLRSLETRQNDNDPVDSPYSIPQDSSSPLRAAGVSTKQKDFTYGPGIGGGPFSPAGPLGIAAIKRDSAIYQKEGGNQLQLTQAENASAAAAVDQYNGLKTLDDYVKLYDGQWERSTSPSGVSPGLLTNYTDDLLFSMERLSFNPYAVRRLTPEEDLPFTVDDEIVRKVSGQPLAELHSSSRLFYIDHREQDKLTRATGGKYSAACDALFYISEAPDKFLPLSIRAKNTDNDGLVYTPRDSPEDWLLAKIMFNCADFFMSQIHHLAHTHFVAEILFQAAIRTLSDDHPVLALLSRIMYGTFGIRPAGATNLFSPGAAIDRYFGYTGASAVQWGAELYASGFAGSIQSNYFLTNLRKRGLIDSPSGPALPRFPFYEDALPLYNATQTFFAAFVGSYYSDPSTITADIELQAWLVEAKGPAQAIDVPDISTPADLVDLLTHIAHLSTSAHHSVNLNQLITSNGVLPFHPTAIYKPVPTQKGITDVASYLPPLSKCLGFLTVGANFARPLLVDSNRSMVHMFDDDVMLSRMNQVTRDANGAFMKDLQARSSEVRARDFDQDGLAQGMPFLWKALDPETIPWSLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M3B6R0</accession>
    <name>M3B6R0_SPHMS</name>
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        <recommendedName>
            <fullName evidence="3">Proteasome assembly chaperone 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_114576</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF15482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="146" mass="15312" checksum="CAF6FB3D0A1BAF95" modified="2013-05-01" version="1">MAADASKPPVVNGLESSNKALELAIDLPHSPGLRLNVHLTILANCIMLFLTSTSSETGPGAVSMGSFVYALPDRYNPTQPMSTALYTAPSSLDFTTRMAKVLTRRLKKPCYVGSSINLSTAAGGGSVDEEMDAFRCVVDTVVSAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M3B7L1</accession>
    <name>M3B7L1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycine zipper 2TM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_147618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016904419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B7L1"/>
    <dbReference type="STRING" id="692275.M3B7L1"/>
    <dbReference type="GeneID" id="27901556"/>
    <dbReference type="eggNOG" id="ENOG502S756">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091798_1_0_1"/>
    <dbReference type="OMA" id="YPQGQNA"/>
    <dbReference type="OrthoDB" id="3650566at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37014">
        <property type="entry name" value="EXPRESSION LETHALITY PROTEIN HEL10, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37014:SF10">
        <property type="entry name" value="RICH PROTEIN MS8, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05650)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF15847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="219" mass="23036" checksum="E63FEB673925F94B" modified="2013-05-01" version="1">MSGPYDYNNQSYGQAPPAPQYGGQQGGYGSDPYSQQNQQYGGQGYNQPQQPPQGSYDQSGYNNQGGYGSAPYGQPGGYGAPPAPQYGSGYDNQGQSTYGGPPNAGGFNHAQAQPSYGQDYTPQQQNYLQQHPPTTNDPNNPYGYQQDPRDPNNPQEGERGFMGAMAGGIGGGLLGHKAGHGIIGALAGAFLGSKGEDKLKQKHHNKPHGGSSYGGSNRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M3BQ30</accession>
    <name>M3BQ30_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_151969</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756384.1">
        <property type="nucleotide sequence ID" value="XM_016907159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BQ30"/>
    <dbReference type="STRING" id="692275.M3BQ30"/>
    <dbReference type="GeneID" id="27904296"/>
    <dbReference type="eggNOG" id="ENOG502T7H1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_674673_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004031395" evidence="2">
        <location>
            <begin position="18"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF08263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="408" mass="41450" checksum="ACF3AF55446349AC" modified="2013-05-01" version="1">MYFSPSLIAALASGALALPNYGSPAETTSTTCTEEESKPTFSAVSTYSPPAPVYSTPVDPPSYPPPAPEYDDAEEDDCTEEWEEEGEGEGEGEYPSATYPAPSHYTSAAEGYSSAAGYSSATAHPGYSSSAGGYSSASVYPGHSSATGGYGGHSSAEYGGSSSSTAGYYSSKPIYSSHPVKPTYPTPSPLYPSVKPTYPSSSPLYPSGNNSTLPSGIPTPTLGPTPPIFTSTSVPSTTSTIRDPLTLTGSLTFSVPSNFTSTFTISDPVTFTSTSTSSAPTTTPTDDPGCGSSENPCDGGEVPCEGCDGSPIDGGIIPNPEGPDDNGGDENGDGVLTDAEICGASNIPSCCTPPTTADDNLFVPGASCSVTDPISGCPAGATYCCPLIDDTQNIDTTQQCALINLFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M3BQF0</accession>
    <name>M3BQF0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_166826</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat rae1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756484.1">
        <property type="nucleotide sequence ID" value="XM_016908261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BQF0"/>
    <dbReference type="STRING" id="692275.M3BQF0"/>
    <dbReference type="GeneID" id="27905398"/>
    <dbReference type="eggNOG" id="KOG0647">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038526_1_0_1"/>
    <dbReference type="OMA" id="EAMDQSI"/>
    <dbReference type="OrthoDB" id="256303at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000190">
        <property type="entry name" value="Nuclear pore complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="115"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="257"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF08363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="360" mass="39563" checksum="660BCC542C23338F" modified="2013-05-01" version="1">MSGLFGSNNANSSANPTQGDLTKDVTVNDPPEDSISALSFSPASDHLSVSSWDKKVRIYEIDGSGNSKGVAMFEHEGPVLDTCWSPDGQKVFGAGADKAARMLDLGAGQTTGTQVAAHDQPIRCVKSFTFNGSPMLITGSWDKTIKYWDLRAPQPVATVDAGERVYTMDIRNDSMLVVGTAERHIRIVDLKQPDKFYKSLQSPLKWQTRTVSTFIDGSGFAIGSIEGRCAIQYIDDKDSANNFSFKCHRQTPADNRNVSHVYAVNAISFHPQHGTFSTAGSDGTFHFWDKDAKHRLKGYPEVGGTIAATEFNRSGNIFAYAVSYDWSKGYMYNNPQTLNKIMLHPVVGDECKPRPKTTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M3BQZ9</accession>
    <name>M3BQZ9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein S12/S23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_152179</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756664.1">
        <property type="nucleotide sequence ID" value="XM_016907287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BQZ9"/>
    <dbReference type="STRING" id="692275.M3BQZ9"/>
    <dbReference type="GeneID" id="27904424"/>
    <dbReference type="eggNOG" id="KOG1749">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115574_0_1_1"/>
    <dbReference type="OMA" id="KFRWSQR"/>
    <dbReference type="OrthoDB" id="1713912at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03367">
        <property type="entry name" value="Ribosomal_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000007">
        <property type="entry name" value="40S ribosomal protein S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005680">
        <property type="entry name" value="Ribosomal_uS12_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003254">
        <property type="entry name" value="PRK04211.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00982">
        <property type="entry name" value="uS12_E_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF08543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="145" mass="15961" checksum="891E1888A1636D8B" modified="2013-05-01" version="1">MGKGKPRGLLAARKLRNHRREQQWADLHYKKRLLGTAYKSSPFGGSSHAKGIVLEKVGVEAKQPNSAIRKCVRVQLIKNGKKVTAFVPNDGCLNFVDENDEVLLAGFGRKGKAKGDIPGVRFKVVKVSGVGLSALWKEKKEKPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M3BST4</accession>
    <name>M3BST4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Sister chromatid cohesion acetyltransferase Eco1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_8993</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetyltransferase family. ECO subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF09153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757274.1">
        <property type="nucleotide sequence ID" value="XM_016910513.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BST4"/>
    <dbReference type="STRING" id="692275.M3BST4"/>
    <dbReference type="GeneID" id="27907650"/>
    <dbReference type="eggNOG" id="KOG3014">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039183_2_0_1"/>
    <dbReference type="OMA" id="WHVYEES"/>
    <dbReference type="OrthoDB" id="428854at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061733">
        <property type="term" value="F:protein-lysine-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028005">
        <property type="entry name" value="AcTrfase_ESCO_Znf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028009">
        <property type="entry name" value="ESCO_Acetyltransf_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45884">
        <property type="entry name" value="N-ACETYLTRANSFERASE ECO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45884:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE ECO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13880">
        <property type="entry name" value="Acetyltransf_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13878">
        <property type="entry name" value="zf-C2H2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="N-acetyltransferase ESCO zinc-finger" evidence="11">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase ESCO acetyl-transferase" evidence="12">
        <location>
            <begin position="183"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="147"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF09153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="263" mass="30020" checksum="ECBED7695E24E036" modified="2013-05-01" version="1" fragment="single">QMQMSLGQKVNRRCDTCGMEYVPSSAEDRKLHDKYHKQNLDGFDLGKDFVAKKRRDGRKLSVFKGVKEGDAIVYLDCYDNHHRKKKGQAVLEVVQRELGAVAIPEAEIWDLKNEEINIPESKYKSFLYIRGNKCVGYLLTQRIAAALEVLKARKQQEADAAKALEDELAEASQHPLHLSDTRHSAVMGISRIWTSSSHRSHGIAQCLLNTAINRHNSIRDLDDHHEEAYTRKQDVAFSQPTEAGAKLARKWFGRAYGWRVYVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M3BWQ8</accession>
    <name>M3BWQ8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Major facilitator superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_65577</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760592.1">
        <property type="nucleotide sequence ID" value="XM_016909724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BWQ8"/>
    <dbReference type="GeneID" id="27906861"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_1_2_1"/>
    <dbReference type="OMA" id="TINCFTW"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF315">
        <property type="entry name" value="TRANSPORTER MCH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="357"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="63"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF12471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="453" mass="49233" checksum="A4D6E96D99B636CF" modified="2013-05-01" version="1">MTDEHHLSALEKEIEATERDSSPERTTTDEEAVQDKDKDNNDNDTREDALLEREEAPPDGGYAWVCCGALAILNAFTWGVAASYGVYISHYLANDYFPGARPLDFALIGGLEFGVAMIISPLCTMLTREWGRLVVMSTGCVMFAGGFIAASFASEIWQLYLSQGVLIGLGLGGIFIPSIQVLPQWFAKRRSLAGGIASGGSGFGGLAFSLGTNAMIEQISLRWALRITGILCLVGNLTATLLVKDRNHVVKPPQLGFATHLLRRYDCVLLLAWGFVNLFGYMAVLYSLSNYAVAVAGLTQSQASLLTAILNLGTGFGRPLVGLASDRLGRIEVAACSTLFNAILIFAVWIPGNSYGVLIFFAIVAGAFIGTFWMTIGPLCAEVAGLAEVPSFLSLQWLTTVLPTTFAEVIALYLRRPSMGRWGYLYAQVFAGSMYLVASFFLFELWRVKRSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M3BXD1</accession>
    <name>M3BXD1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_149314</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760857.1">
        <property type="nucleotide sequence ID" value="XM_016905483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BXD1"/>
    <dbReference type="GeneID" id="27902620"/>
    <dbReference type="HOGENOM" id="CLU_1982963_0_0_1"/>
    <dbReference type="OrthoDB" id="5627at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF12736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="126" mass="13864" checksum="2528236F43BA7CFB" modified="2013-05-01" version="1">MADQSSDAPPDVVFRANKRRKMIRKRNLDDLDEAARIEPQDTGVDVSEDNSKGLLSTVKRPAMRKHGIGFSTTGSQQQGPDATTVVETALVPTQNNEEEPSPHDRFTKPTEKAAVVVEDRHLVETG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M3BZJ0</accession>
    <name>M3BZJ0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_155764</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761587.1">
        <property type="nucleotide sequence ID" value="XM_016907644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BZJ0"/>
    <dbReference type="STRING" id="692275.M3BZJ0"/>
    <dbReference type="GeneID" id="27904781"/>
    <dbReference type="eggNOG" id="ENOG502SIH9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020425_3_1_1"/>
    <dbReference type="OMA" id="KFAFIIP"/>
    <dbReference type="OrthoDB" id="422736at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22997">
        <property type="entry name" value="GT_LH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36587">
        <property type="entry name" value="EXPRESSION SITE-ASSOCIATED GENE 3 (ESAG3)-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36587:SF2">
        <property type="entry name" value="EXPRESSION SITE-ASSOCIATED GENE 3 (ESAG3)-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF13466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="626" mass="70760" checksum="9ED5243994E6C8AA" modified="2013-05-01" version="1">MCISLISSRMCRPLFLPAVTVQSNGIAFAAPDSGSEVKVDAVEIHVRQTSDRAVTIRAWRVAFASMPLAESRELILWTAGGDTGKDCFAAVVYPAIVVVDAMQTPNIVARFTRSASGSPRRVHFNEDERYEEKKNNNKRWESTAKRPSHGQAYMNRTFLGKRPLAAVLFIFATFFAVLVVRSYSTAPVHSHTVHNGPTAKYMQLIIPINRKSDTDLCKTVLSAQVLNYPVPVVVPWGNSTDGTLVAKKQRMHHKATQIYSYLNSLPREADDGIAILLDGPDTWFQLRPESLLQGYYRITSRRNRKLQKSHGKGFEQKVVFSASDVCGMSDENDPSCSVIPQPPAANLPNYLGHGAIVGQVQDVRKVLARVIDKLETQQEEPPSRLLPIFTHIFGEQEARRQQYRIIKPHQKHNRRPRQVTEAATPPPPNAFNTTNEAVELGIGLDYHNELGFSISPTTLPQWHQQTSSSQSAEIQSSMPPYWTVSGQEPNLPHHKTWSEIPLFATTKNNNSIPAMLHHYPTVAMGGHDATGHRSQWWSQMWFTEFSRALYTASERLPSTIVAQVRVDDGQEGKEHVFWNLWPSHNRAGAWLSGGKFWHWQDMCGLEGQWREVFRDEEGPWVRREWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M3C2I7</accession>
    <name>M3C2I7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_148167</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762587.1">
        <property type="nucleotide sequence ID" value="XM_016904751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C2I7"/>
    <dbReference type="STRING" id="692275.M3C2I7"/>
    <dbReference type="GeneID" id="27901888"/>
    <dbReference type="eggNOG" id="KOG0714">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006836_1_0_1"/>
    <dbReference type="OMA" id="YGPPKAN"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43948:SF23">
        <property type="entry name" value="DNAJ DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G15460)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43948">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="9"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="377"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="421"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="454"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="589"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="642"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF14466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="951" mass="102950" checksum="B054F32BD5BE53A2" modified="2013-05-01" version="1">MVKPDLKHNYYQDLDLPITASVDDVRKAYRKLALQFHPDRNAGREEECVPRFQAIQAANEILSDPTLKAKYDADRRKVGLYPSFTRNNAPGSTGSPYAARSDFPPPPRRTQPGTWQRPGGQTAHGPQPTGAERFTNFPRPAGAAPQKNPAADRTQQFRAWQNMKEPSTAHRPQPPEVPPRQQAPPRSPQPPTPGAAPTSARPQASRRNTNLEERIRAGMRHGTTAGPSAEEAASRQSAWQSFQNSNAGQPGMNSNGQRRRPPATPKRPGGFDPNAPGSDERPAPQSSHYVHRHKSDDFGGDGFPPPPPGPPPGSAPHSPTSPDTQRPSRSRAFNDDAPYAEANRTSTPYSSYIGEKTAFNASGLARSASVRDTTKLSPESANSSSSTRARSVDPATRRTQASSGSPTHPPYANENAARMRSASTSTSTSEESSDDNDDGDDDDDDDVDDVPEQRPTSGPPSRTSSNTAQPGGPAGRNIKTPKPPSRFFPNRNGATNKYPLPDNDGSAHTDGEQATKQERKKSENIFSFPIDPETFKQTKGKSRSVEEINTTFSPGGFHGKFEGSGDYFANGDARRPSPAHRQSSRRSQRTATTDSTSTSNGTSPMPRAPQPATGDTSQPGPNAPFSPEAWQKTFSDGGAFAWPPPPPGPPGFKAPSRKSSRATRANGKGPTSGSAQQPHVIDDDVVIGVDSTGRPMNSSAFPDDGDAMDIDTPPPAERAAPAEEGTPLAKEARLYSVPPSEWRQQQASQPQQLRHTSGSARRAERKSAGESSLNVNLDDLRHTEPFARSNDGLKGMGDLTSSLPFTSKASSVLQTQMPRPVSYLQQSVPLPKAPEGPTKLTRTSWDAYYQKFANYLVAFHSWNKAYLQYFESCEQEAETRIKSGSGWLVQSGDTVNGTKGFASYLRSARDENQTRVVYGLGRDKHLEAVESFDKIRERVRALTESGTLADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M3C665</accession>
    <name>M3C665_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_147561</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763887.1">
        <property type="nucleotide sequence ID" value="XM_016904381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C665"/>
    <dbReference type="GeneID" id="27901518"/>
    <dbReference type="eggNOG" id="ENOG502S12X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034313_0_0_1"/>
    <dbReference type="OMA" id="SINGWTR"/>
    <dbReference type="OrthoDB" id="411785at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051419">
        <property type="entry name" value="Lys/N-term_MeTrsfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176:SF84">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF15766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="308" mass="34553" checksum="97F22567F6FA028A" modified="2013-05-01" version="1" fragment="single">MPDFSSQEYWNARFSKDPHTFDWLVPAKVLHDIAAEVIDKTSLEEPRILHIGCGTAESHTLRSLVQNPKHVLNVDYSEAAVQAASKREQELLASAHIESLLAPPDSSSAKHDSVQDPEPEPPMRWSCKNLLSLHSALSMLHAQQAEGKLFDLVLDKSTSDSISCGQDVSLSLPYPLSINGWARRVLGTGTGQLREVHPLHVLAVHLAALTKPGTGRWIVISYSEERFPFLPPFPTTLANGMLSDDVIQAGFTHPHQLWRLEAKEQINLEENNETLAERKKRLSAGYVHRPRVCHWLYIMRRTDAFVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M3C7R7</accession>
    <name>M3C7R7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_136784</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF07930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756051.1">
        <property type="nucleotide sequence ID" value="XM_016902799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C7R7"/>
    <dbReference type="STRING" id="692275.M3C7R7"/>
    <dbReference type="GeneID" id="27899936"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037639_0_1_1"/>
    <dbReference type="OMA" id="IKAHFAS"/>
    <dbReference type="OrthoDB" id="167718at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12400">
        <property type="entry name" value="RRM_Nop6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000376">
        <property type="entry name" value="Putative RNA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034228">
        <property type="entry name" value="Nop6_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF51">
        <property type="entry name" value="NUCLEOLAR PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="135"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="214"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="112"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="266"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF07930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="347" mass="38462" checksum="2AA42BE64BFC81E1" modified="2013-05-01" version="1">MSQEEASSISRKEKKAKRDAERAQQKGKKRKHREIPEPDALPKQDDDDVGVEEVAAEGVKSATKASKKRKAGDTFEDATADPTLAVTTSASTDKDDDDNTQPKKKRRKSKKTAATTTITDEDGNTTTGPPKKSRFIVFVGNLPYKTTDSSLQKHFAKLQPFTLRHRTDPKTNKSKGFAFLEFENYDRMKTCLKIYHHTMFDPEAIDSGKVEGGPDAGAMPSGTGANSHGDNVNGFHPERQRQIRGRQKETARKINVELTVGGGGGKSDERKEKIKEKNERLNEQRERRAELEKKELAKKAAKEGGAKKIKKTGANADVVVQEENIRPEKAKVEDGAIHPARLAMMGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M3CBR1</accession>
    <name>M3CBR1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sm protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_150972</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the snRNP SmB/SmN family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF09862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757983.1">
        <property type="nucleotide sequence ID" value="XM_016906513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CBR1"/>
    <dbReference type="STRING" id="692275.M3CBR1"/>
    <dbReference type="GeneID" id="27903650"/>
    <dbReference type="eggNOG" id="KOG3168">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076902_1_1_1"/>
    <dbReference type="OMA" id="KMINYRM"/>
    <dbReference type="OrthoDB" id="2020720at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070990">
        <property type="term" value="F:snRNP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01717">
        <property type="entry name" value="Sm_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000047">
        <property type="entry name" value="Small nuclear ribonucleoprotein SmB, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050914">
        <property type="entry name" value="snRNP_SmB/NAA38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701:SF0">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B AND N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="5"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="95"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="149"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="169"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF09862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="207" mass="20337" checksum="77165FA11BDBA8DB" modified="2013-05-01" version="1">MASQQKQGKMQGFINYRMRATTNDGRQLVGQMLAFDKHMNLVLADCEEFRKVKRKAKQGGAPGATTSGQTVETEEKRSLGLAIVRGANIVSCSVDGPPPADPSARLGQSAPGGGPAAGVVQAGPGLAKPAGRGAGIGLQGPAVGVGGPGFPGAGFGPPGGFPGRGGPPGFGPPAGFPPGGPPGFAPPGFQPPPGGRGFPPGPGGFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M3CD35</accession>
    <name>M3CD35_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypoxanthine guanine phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_88137</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF10976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759097.1">
        <property type="nucleotide sequence ID" value="XM_016910464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CD35"/>
    <dbReference type="STRING" id="692275.M3CD35"/>
    <dbReference type="GeneID" id="27907601"/>
    <dbReference type="eggNOG" id="ENOG502QRN9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092544_0_0_1"/>
    <dbReference type="OMA" id="TYNDVHN"/>
    <dbReference type="OrthoDB" id="9973266at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052657">
        <property type="term" value="F:guanine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004422">
        <property type="term" value="F:hypoxanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000310">
        <property type="term" value="F:xanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032263">
        <property type="term" value="P:GMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046100">
        <property type="term" value="P:hypoxanthine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032265">
        <property type="term" value="P:XMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000033">
        <property type="entry name" value="Xanthine phosphoribosyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43363">
        <property type="entry name" value="HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43363:SF1">
        <property type="entry name" value="HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF10976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="204" mass="22858" checksum="D529DE943D425B79" modified="2013-05-01" version="1">MVEKVWITYNQTHKLCQDAAPRILKDFQPNLMIAIGGGGYVPARMLRSFLKQPGAPNIPIQAIGLSLYEALGTDEQVEAPGTKVTRTQWLDLTSLEMVDLVGKSILIVDEVDDTRTTLEYAVKELQKDVDEAAKKAGRGAETTKFSIFVLHNKDKAKKGTLPEEMISNNRYLAARTVPDVWINYPWEATDIDEHDRMAAQQTIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M3CGL5</accession>
    <name>M3CGL5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_156498</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761044.1">
        <property type="nucleotide sequence ID" value="XM_016907677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CGL5"/>
    <dbReference type="STRING" id="692275.M3CGL5"/>
    <dbReference type="GeneID" id="27904814"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_364919_0_0_1"/>
    <dbReference type="OMA" id="AYRCKWE"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24376:SF235">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24376">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="420"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="60"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="111"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="219"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="480"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="294"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="494"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="528"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="564"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="596"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="611"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF12923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="765" mass="84244" checksum="D777C8CAD4264EC8" modified="2013-05-01" version="1">MLPVTSSSIQKRRQTHRRQQSLEVPILATPLPQHRRTKSKPTIHRRGLSVDQAMSAMNSPSQFRPLLPQDGYSGLPSGPPSLRNHQPLDTNTAYPLQEQQHQQHYIIKQEPQSQSLPPPLSAPSLAQPHPLPPQPQNFQSHLHQQLNGMFNPSVSAISAESQQTAAYQSLQSHMAWYASQFGLHSPNPHVNGQSQPVIQLSQPGSDEMAGPVFLSQPQIQIMPGTPQPQAQSHTVPNTPQNHAQSWPSPPSSHVKHQRRQSWQLDVAPMPQQQVQRPVYGLDGSFSFNGEQDYSASYSSSVADPSSPSQQHTASMPTLYEEPSADLLLQATAGAEQDFNSPHFMVGGGHMCPEQAALDAAGIDATYIDTGITEEQINSWLIHPTGKGEAYRCKWEGCDTVINRKENARSHVQNHLDDRRFRCNPCGKRFNRLHDTKRHHLTHTNERPAVCPCGKTFARADALTRHRQRDMCEGVLPGFQKLEEEKPKRGRPKKDRSGDGNKSKKSSRPDMEHRTEKAALARSMDRATRSQAGSFSSAASERSMPRTPPQQSEEMSAHDFLNMDQPDSQFNAATGSWIDTPPSSPPSASHAQLSKTKPFELHIPEDRIVSPSKLSNRASPAPTSKSHHDSHHDCSSPGGHGNSSFMDYSSPAAYPGFHGGSGMDGVDIFNEAVDFDVLNSHPEVGRQVFSPPGESCSSSSVYNSDYETVYAPAAVKPPAHLTTISEYGVTTTNRAPFDLEDCMAGTDDPYNDIRDMLDSWISATGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M3CHR5</accession>
    <name>M3CHR5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_155663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="3907968at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="508"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF13328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="574" mass="63197" checksum="C3F384AD1EF18E31" modified="2013-05-01" version="1">MLMQIGHLNDERAPYAARGDNIDSQVHYLSMGGTYLHVGTGNESPESPGKLESCFPPTNIGDSFHLAQIPSIIPSRFHHRHFPACDSRSPTNELRKHAYACTRIIMDSGLQTDCFGATPATPAAAGTLAGASHHPARRSAYMHVRSTRALTTNAELRRNKPFVDTDPGRDARPLSSELGLRDRSAGTRLCTITEQQSIPTLKTIPSTRTFQRRLASPEPQLRRERSAAPAVQRRRRLSADDILAKVFLRSSSADLPDIPRRAEPLYDPPHRRHTPPGFPRWPGENETSARSDGLRRPISNWPLLMQWLRAHTRICAPQDWQQQHLLREIAWNRSRPSGERHWRPPRSAHSTHRFADLSSHPFASAPPGHVALTQSQRSLRYASENHVPVTPTRAQARLAQRSAPLPSNLYSSSSSGRSLRTLALHGTVQQGNEIPAQSTPKLCKHQLSKLKNTQAISSPVLLAHHGQSVSSLDGSLDGTSPEIALHEISPIAIRDHAALHVPSTVSDSRPVLRLQSDSDEPPSPTTRVLGSSPNEADDATFDVHPDHPMPGITHATTFSTDVSCDTMTDPQGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M3CIX6</accession>
    <name>M3CIX6_SPHMS</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_107723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016900695.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="27897832"/>
    <dbReference type="eggNOG" id="ENOG502RP1I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_359396_0_0_1"/>
    <dbReference type="OMA" id="MKMIPQP"/>
    <dbReference type="OrthoDB" id="3919589at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="636"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="686"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="209"/>
        </location>
    </feature>
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        <location>
            <begin position="457"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="552"/>
            <end position="563"/>
        </location>
    </feature>
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            <begin position="564"/>
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        </location>
    </feature>
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            <begin position="595"/>
            <end position="608"/>
        </location>
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            <begin position="636"/>
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        </location>
    </feature>
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            <begin position="692"/>
            <end position="715"/>
        </location>
    </feature>
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        <location>
            <begin position="718"/>
            <end position="728"/>
        </location>
    </feature>
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        <location>
            <begin position="741"/>
            <end position="750"/>
        </location>
    </feature>
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        <location>
            <begin position="759"/>
            <end position="778"/>
        </location>
    </feature>
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        <location>
            <begin position="828"/>
            <end position="847"/>
        </location>
    </feature>
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        <location>
            <begin position="848"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="876"/>
            <end position="894"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF13758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="941" mass="103725" checksum="1C2B40B896D9AE9E" modified="2013-05-01" version="1">MELFMSDRPLSIFGTTQAAWNMPQSQTTSSPLKRPPIGSPLSTTLYTQPTVARPPLLFSKNSSSSSLGGLEQNIPPKNIPPFQAFLLTTPPLKHDPDKPLPPTPSQIPAAVDDYDTSFRRRSSSVYSRTPSYWAVESIESWQTNDLEEISRTVLPPIAYSVSVPDFKSQDAAPAFLQPRKFSPLLTSPRMSIQTISSSNLSSGATTITTPPTPTMLSSTEAPRQKPAMISLHEAKETLHAPGAKILLPEELRAQAGRKNTRESQGHVRLSSSDIFRMHAPPEAPVVATLVDRQGRVRSITTPPATISQFLDDVSPPLDNRLPSVNAFPVGSGPAREMVPPTPTVAEHFFQQQMNGIDSDERGRVRERGRASLDVSKYKFPASPETYVHDPYRFQMGDKPTNTAEEYHTLLAQTYQKPSPATSEYDSDDSIRRHMKMIPQPLFSGKQPPARKSGALQGSDSSRYGRSSQSSMSSRGSNSFNLRLSMSPTGSRRTSGGSGSGFGDIPISPPRQDVHKPQSISVGSKGAARPAESHRYHRDSRFESKYYPQPLQRADRTASIEQKQKKNQKKSKNKSRPSFSVTSRPVGASSHRQKPSKNSTESPMTSPTLGTGYAAVLNPPGAPLLTKSVIEMKLKTPLSSPQSSPLGSNPSTPEPQSSTSGHGNVPLDESPVLGNKKHFLQRVAMKSMRRANHKDDNHDDDHNNDNNGEVRGEGRRQSRNQFPTTTDSPHLNRDISPFSKPTTPPPHPSPHSPHLYPRNSISITSSSPSTTTTKTSTKPSMKKLELPPHLGWSNDKKFEFDSATTPPPSTPVSARSRINLLMTPSRSSPGDHHEQEWERGFAARHGREGEEEEEEEESSPTTTTDSWRRKGSLFGNVRDRFVESKAQRRREDLKKMIRVVPNQGPVAESNGDGKVDRKASVTAPEGRRMSIFSRRLSEFNWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M3CJ34</accession>
    <name>M3CJ34_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_148983</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761929.1">
        <property type="nucleotide sequence ID" value="XM_016905266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CJ34"/>
    <dbReference type="STRING" id="692275.M3CJ34"/>
    <dbReference type="GeneID" id="27902403"/>
    <dbReference type="eggNOG" id="ENOG502RKW9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_819320_0_0_1"/>
    <dbReference type="OMA" id="IGSAYTH"/>
    <dbReference type="OrthoDB" id="2129069at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF13808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="339" mass="37606" checksum="58D4FE5274A71F3A" modified="2013-05-01" version="1">MHLADMMATPPAPTLFCNSLRRRPSFASAIPTLLRQSRFVVRGISASLLLLPPPIPTDCSLHMPGIGSAYTHNLVEQLLDTHDVAVPITWEVHPQAGHTRPTRHLRFLLLSPSALLDAKLDTTIERIRHFSFLTTEPIAIIFLLNPPRETSFRSAKHLGQTAIELSSDRVDGVLGYVKLQAEMMNRSDLPHIPILPLNHLVGLEPLLSKHAALHTEHQPGRQHDDAAAAATSRQLMQFCTLRQPMQEFTANVLSDTFDNLQDIAKTMVTEPTTPYSSSPTAIAAFALNVLSQDCDENGTLRPPSDDATPQGKLRMLKGILGEVETAEMVEFWREEYQVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M3CJ97</accession>
    <name>M3CJ97_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_133060</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761989.1">
        <property type="nucleotide sequence ID" value="XM_016902538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CJ97"/>
    <dbReference type="STRING" id="692275.M3CJ97"/>
    <dbReference type="GeneID" id="27899675"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_12_0_1"/>
    <dbReference type="OMA" id="DQKSHIE"/>
    <dbReference type="OrthoDB" id="3819888at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF4">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_7G04540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="227"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="237"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF13868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="293" mass="32081" checksum="587093819B9C949B" modified="2013-05-01" version="1">MSHNNDSFKLVNVFNVKGKVALVTGGGSGIGLMATQALAVNGAKVYIVGRTQDKLDTVVKTYSQGIEGQIIPITADISSKESIKKLYKEFSEKEDRLDILFNNAGISTATFKTESKSAEEMKKNLFDNEEATFEDWEAVYRTNVGQLYFVTLAFLPLLQKATEKTHGWSSTVINTASMSGEVKTTQHHPQYNASKAAAKHLTRMMANEFQENGLKIRVNSISPGVFPSEMTAGESDGNQKSHVEKEKYEGKTAAQRPGKDEDMAGAVLFAVTNQYWNGQNVTVDGGYELISGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M3CK91</accession>
    <name>M3CK91_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_106564</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762329.1">
        <property type="nucleotide sequence ID" value="XM_016900643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CK91"/>
    <dbReference type="GeneID" id="27897780"/>
    <dbReference type="HOGENOM" id="CLU_630324_0_0_1"/>
    <dbReference type="OMA" id="SWANEAR"/>
    <dbReference type="OrthoDB" id="3645550at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032506" evidence="2">
        <location>
            <begin position="25"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="382"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF14208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="435" mass="47364" checksum="69E7E2B13BC73D04" modified="2013-05-01" version="1">MSLRTLYLLWLPIALLGLVLPSRGQSNAAHILARNALADQIASLAAEYGANVDTSLSGYDHDLVTEALKEGQQKRSALRAREIIAQEATVVKAQLGDNVDTSLDGYDLGDTEDEDTISKRSAILARDDIAQAASAVTSQYGSKVDTSLEGYDLGDLEDDNASQDTVTKRSIIIAREEIDQQAPAVKAAYGDKVDTSLDGYDLTDLGEEKRSIILAREELAQEASVVESQLGSSKVDTSLEGYDLAALDDDDDNTLSARDLFDVDESLTGDMPISSHLKNYGPGHETDDDASLPRYDDDSTITRRDDNDPEEEEEEDDDEDDDDDDVPSWANEARKRDFPEEAEDDDDDDENESVEADYVTDDDTSNDRYHDDTPEVMNGGDASAAQATTATSTANNKQVRSASSSSSSSSEGEEEEEEEKGATGFIKIVKRYLNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M3CLB3</accession>
    <name>M3CLB3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_155265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762704.1">
        <property type="nucleotide sequence ID" value="XM_016907608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CLB3"/>
    <dbReference type="STRING" id="692275.M3CLB3"/>
    <dbReference type="GeneID" id="27904745"/>
    <dbReference type="eggNOG" id="KOG3117">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065858_0_0_1"/>
    <dbReference type="OMA" id="RHTKSER"/>
    <dbReference type="OrthoDB" id="203440at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007146">
        <property type="entry name" value="Sas10/Utp3/C1D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237:SF9">
        <property type="entry name" value="NEUROGUIDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04000">
        <property type="entry name" value="Sas10_Utp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF14583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="360" mass="39186" checksum="2E93BAB0FF2FE22A" modified="2013-05-01" version="1">MATVPALHEVLADFENATNAAVNGLPTSDSLLPPENGITLLDTKNEIFLAYLQALALRNLSVIRSIKSGSDVDQAQRLSNDITKSLVEQRVYLERGVGPLEKQLKYQVDRIVRAADDEERKVKLKLQQAVKANGHAEKNEAEGSNESDSDSELDSDAELDADSTAYAPKAALMGNSAQSSAVSSAREKSASDGVYRPPRISATSMPTTERREKKDRGPGRSATLDEYVSTELSAAPLAQPSIGSNLAAGGRTSKNARQLKEEAERRDYEETHLTRLPLMSKKERAKKGLRRPQDGGFGGEEWSNLGASLDRIGDLTKRKSKDSALDKSRKRRAVEDGPRGDGIGASFDTKKRRLAKKGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M3CMG5</accession>
    <name>M3CMG5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribokinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_146993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF14993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763114.1">
        <property type="nucleotide sequence ID" value="XM_016904013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CMG5"/>
    <dbReference type="STRING" id="692275.M3CMG5"/>
    <dbReference type="GeneID" id="27901150"/>
    <dbReference type="eggNOG" id="ENOG502RXMJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032834_0_0_1"/>
    <dbReference type="OMA" id="VIKSWNT"/>
    <dbReference type="OrthoDB" id="497927at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47098">
        <property type="entry name" value="PROTEIN MAK32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47098:SF2">
        <property type="entry name" value="PROTEIN MAK32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="1">
        <location>
            <begin position="192"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF14993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="353" mass="38443" checksum="EF4F0877E262715B" modified="2013-05-01" version="1">MTSSTKRTVPIDFCTLGMFIIDEIHPPKEAPNQEPQLNVIGGAGTYSAIGARLFSPPPHSHSVGWIVDAGNDFPDELRATIRSWKTGALIRDRAAPTTRGWNGYSGNQHRAFKYLTEKKRLTADDLTSDLALARSFHLICSPLRAIDQVNGVISKRASMHDSLSIREQSRPVFIWEPVPDLCTPEELPNTFTALRYVDVISPNHEELAAMFSFTHPLEGPSKAAIESHAQQLLDAGIGPDKQGAVVVRAGAEGCFVLSATQRLWLPAYHTDASRVVDPTGGGNGFLGGLAVGLVRTNFDVVEAAKWGNIASSFTIEQVGMPVLETSADEDGAQEKWNGASVQQRLAEYRERTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>M3CMP8</accession>
    <name>M3CMP8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_38644</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763209.1">
        <property type="nucleotide sequence ID" value="XM_016908712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CMP8"/>
    <dbReference type="GeneID" id="27905849"/>
    <dbReference type="eggNOG" id="ENOG502SHZM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008599_1_1_1"/>
    <dbReference type="OMA" id="LQTMPEE"/>
    <dbReference type="OrthoDB" id="3362851at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="34"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF15088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="726" mass="81733" checksum="7D5E6E2758993E25" modified="2013-05-01" version="1">MFNTFQVITSSEIATTGRGGRPQRSPRRISTANACVECRRRKIRCDGLQPCAQCEWFRIPDRCMYSKPTQRVVPPKRIVERLQSQVDQYQAIVAQLFPGKDLQEVVALSRDGMIDLAMNLSAAGTCRDHHHGRPLARLQSVSKSEGMNNGHDASEETPDQCLELEDLKRLHDIIQGTPDDIVQGLSLVDEASSSYVGVSSITTAIKVMFETVPRARSFIMPAQTVGSSVEGTCSRPHDLDPDPDELPPESIGIKLIDSYFAHVHILMPMLDEESFRYRYQHQSRRDPPWLCLLNMVFALGSLSRSTCDSEEHLVYYQRARKHMDTETFGSGNLLTLQAFALLSGCYLRFLNRSNEAYAIMGATLRMAIAQGLHRDSEAPPTVSVACQGDAETTTEARRRTWWTLYVLDTWASSTTGQPLLGRAVAGMTTRFPRLPEQLDDTQHTGLLPLRHNVAYCKLATKVQDAVAANITIPFEELQALDIELERWHEELPPILRDAIERHCPGVLLTPRAIMHWRYQNLKLLMCRPTLLATALRGSSWSTMSADQRLIVGRCRMFATQTIADIETSCQENLVAGGHAVWMMYQAVMVPLVSLYSNLARPSASDDEIESWEQDVEKAITFFDRMQPWSLAAGKCRDTVQQLYNAMKLVAQESVAPRPQADASAPLSTVCEPQTMVQHDSVHIAETISPNINSDAVMTDFWDDMMRELPNCFNPQYEWWTPQDWPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M3CNE5</accession>
    <name>M3CNE5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MYND-type zinc finger protein samB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Suppressor of anucleate metulae protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_147229</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in determination of the onset of polarized growth and morphogenesis. Plays a role in the regulation of branching in hyphae and spore formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MUB1/samB family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763429.1">
        <property type="nucleotide sequence ID" value="XM_016904161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CNE5"/>
    <dbReference type="GeneID" id="27901298"/>
    <dbReference type="eggNOG" id="ENOG502QTM3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014851_0_0_1"/>
    <dbReference type="OMA" id="QDMQYWA"/>
    <dbReference type="OrthoDB" id="5594178at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990304">
        <property type="term" value="C:MUB1-RAD6-UBR2 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.140.2220:FF:000003">
        <property type="entry name" value="MYND-type zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051664">
        <property type="entry name" value="MYND-type_zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47442">
        <property type="entry name" value="MYND-TYPE ZINC FINGER PROTEIN MUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47442:SF1">
        <property type="entry name" value="MYND-TYPE ZINC FINGER PROTEIN MUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="12">
        <location>
            <begin position="573"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="142"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="275"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="369"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="217"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF15308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="640" mass="71691" checksum="6EBE129D08665520" modified="2013-05-01" version="1">MREVNFSIPSANKASVGITTALYDRRALDCTSTLPLINSLNNLAYLTTSSGRIRDILTVDGGIERLVCILKEGRSKDMMEMWKWNLAFQCIVNIGVRGSEAVRTRVVEADMVPVIATILDNYFQVVEKSRERLELESKKKCPFGSSRNFSRSSSNRVETQEHRSGRSSRRHAPPPISIPEPSESPEDEPTSEVTPTVHTANLSLSSPPGRTVFPRQHPQNRSNGGRVQFTSPTATTNRQPEPPVSSLTLQSNDFVRPVRYVDRLPSMIAAIQAELSSQPQSPTTPGPPAQQPESSQPRRRPSIRHQLSMSGSDDDGQIEDAVDERSTGTELEPMIGITGTDLAMEDIRADMGPQNTGVALTDLADVSSADDDTFHIPQPSNDGSHTTPTQGQTNLAQAQVPPPGTINVTSPTLQQPPAWYPQRGLPLDRSAPASILAAMPRDEDVLMSLQLLAYVSKYCNLRSYFQQSHLVPRLKIDRELKMLDPDYNPATHSLPTQDELEDEWDNEFVKKDGEKPYNIFPLIEKFTAKSSSSRHTPVPSSPQQGDMQYWAGVVMRNLCRKDDSKGGIRQCAYWQCGKWEEFTRQFAKCRRCRRTKYCSKECQKGAWGSHRFWCVAVEDSREGEGEHRHRSHRHHHHHGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M3CY77</accession>
    <name>M3CY77_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_152255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756762.1">
        <property type="nucleotide sequence ID" value="XM_016907333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CY77"/>
    <dbReference type="GeneID" id="27904470"/>
    <dbReference type="eggNOG" id="ENOG502SB4T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_146824_1_0_1"/>
    <dbReference type="OrthoDB" id="5304367at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF08641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="160" mass="16668" checksum="AD978FD855D67FEE" modified="2013-05-01" version="1">MGARLSQPRAPAGTTDSTVPVKAGLPPNPRPRINSRTIVAPAAAFTMAILLFVYARTSIRAAKANAQRHRDADTGGGGLSLLAEHRRRHGKAEKVEGTGGGIVAELGREVFKGSGSQEDSVGEKRSGEKVKSGKEEEEDKLKAVMRPGRRGQSGGSGGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M3CYL2</accession>
    <name>M3CYL2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_151703</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756882.1">
        <property type="nucleotide sequence ID" value="XM_016906989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CYL2"/>
    <dbReference type="STRING" id="692275.M3CYL2"/>
    <dbReference type="GeneID" id="27904126"/>
    <dbReference type="eggNOG" id="ENOG502R1W8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_900685_0_0_1"/>
    <dbReference type="OrthoDB" id="3648995at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000837">
        <property type="entry name" value="AP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23351:SF24">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23351">
        <property type="entry name" value="FOS TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="6">
        <location>
            <begin position="216"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="175"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="234"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF08761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="309" mass="33992" checksum="CF24A5A2767B898A" modified="2013-05-01" version="1">MASNSPRVEGHEPSLSFEGAGNAQVSDATDDRKTIPLPTPNTWLTQQLPEHYSLDLETQSYQSLHNAGFFWGDDQIATYPSLTASPDMPTTNTLPYPPTQTHPLYHTHELPVGGHKFTTSDTSATTYQAHPGMRTLTPGNVAESGLEERPLQSPMFSQRNITGLRTAQSAVDMTNVAPSSWPHGSGSLPSEEMHRTENPVDESPSGSEAGDDSPGDVKLKVSREKNRIAAAKTRRKKKTKAKEIEEHAQQIEQTNVRLHQELRTLRDTFSTLRYCALSHDPTAGCTCVGIHQYNAHMAKEVAKEVAKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>M3CYV6</accession>
    <name>M3CYV6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_136193</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat TAF5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756967.1">
        <property type="nucleotide sequence ID" value="XM_016902762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CYV6"/>
    <dbReference type="STRING" id="692275.M3CYV6"/>
    <dbReference type="GeneID" id="27899899"/>
    <dbReference type="eggNOG" id="KOG0263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005884_0_2_1"/>
    <dbReference type="OMA" id="HNHPVWD"/>
    <dbReference type="OrthoDB" id="10266330at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08044">
        <property type="entry name" value="TAF5_NTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.500">
        <property type="entry name" value="TFIID subunit TAF5, NTD2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007582">
        <property type="entry name" value="TFIID_NTD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037264">
        <property type="entry name" value="TFIID_NTD2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF1">
        <property type="entry name" value="CANNONBALL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04494">
        <property type="entry name" value="TFIID_NTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160897">
        <property type="entry name" value="Taf5 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="TFIID subunit TAF5 NTD2" evidence="10">
        <location>
            <begin position="83"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="373"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="451"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="491"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="533"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="577"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="627"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="233"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="654"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="658"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF08846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="728" mass="79481" checksum="3C9F0C65C8828C9C" modified="2013-05-01" version="1">MASQPPPPSRTTSVGPQSAGGMSGPPPATAPGGAGGNQQQNLNQIVLEYLSKKGYSRTEAMLRKESANTDPNGNPILNSIDEMGGKKYGRAFDLTYNWVDNVLDIYKPELKRLLWPLFVYSYLQCISEFYSRDAEEFFGRFKSHFERERSEDVRALSRLYEPEHAQDNQVAQLYRNNKYRLTLSNMAFQTLMTYLENKDSEGGRIVTSIIAQHLDIRVVDRAAAGAERSLAKMITNRGGQDDVPAEDEGIPGHNPGSANLDPKAPAVLSKLTLGPLPMESELVEDVKAELQEHDASHPPGPGQNSLIDQFEERIKREEPDDAAPQRDALPFPPSTARDVAMEVQRVKENRDRFRIEGKTGGVGPGVSVTMFTFHNTYDSVNCIEFSGDNCLAAVGTAESYIRVWSLDNRTLTSPTDPPQFQPSSSRRLIGHSGPVYALSFSPSIAIPEPQTNGHTNGSTSSNSHPRYLLSCSADCTIRLWSLDTWSNLVVYKSHNMPVWDVRFSPYGFYFTSCSADRTARLWSTNQIAPLRLFVGHDADADVVAWHPNSAYVFTGSGAPDRTVRMWDIQRGQAVRIFTGHVGNVTALSCSPSGKMVASADDRGEIILWDLARGRLVKRMRGHGRGGIWSLDWSVESSVLVSGGADGTVRVWDMQPNGDGQGKVVGEGGTGTKIDGATSGGGAGTKGKSKKDVVVSPDQISAFPTKKSPVYKVGFTQMNLVIAGGAYLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M3CYZ1</accession>
    <name>M3CYZ1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 18">CDP-diacylglycerol--serine O-phosphatidyltransferase</fullName>
            <ecNumber evidence="5 18">2.7.8.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16 18">Phosphatidylserine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">SEPMUDRAFT_151781</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>a CDP-1,2-diacyl-sn-glycerol + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16913"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="17 18">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18 19">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.8" evidence="5 18"/>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756997.1">
        <property type="nucleotide sequence ID" value="XM_016907044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CYZ1"/>
    <dbReference type="STRING" id="692275.M3CYZ1"/>
    <dbReference type="GeneID" id="27904181"/>
    <dbReference type="eggNOG" id="ENOG502QPJG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049944_5_1_1"/>
    <dbReference type="OMA" id="HGCGMIS"/>
    <dbReference type="OrthoDB" id="448573at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003882">
        <property type="term" value="F:CDP-diacylglycerol-serine O-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006659">
        <property type="term" value="P:phosphatidylserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000022">
        <property type="entry name" value="CDP-diacylglycerol--serine O-phosphatidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004533">
        <property type="entry name" value="CDP-diaglyc--ser_O-PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016271">
        <property type="entry name" value="CDP-diaglyc--ser_O-PTrfase_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00473">
        <property type="entry name" value="pssA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF61">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000852">
        <property type="entry name" value="Phosphatidylserine_synth_fun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 18" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 18 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="14 18" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15 18" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 18 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00060701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR000852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EMF08876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="243" mass="26567" checksum="FA62DBA1675D5775" modified="2013-05-01" version="1">MSKRNGVVNEVEQSTKEVASEPPKDKQERLLNDPNPGHFSLVRAYHLADLITLMNGFCGVMSVLSSLRYCIGRPEDTGNAWAALALMPLGLFFDFFDGKVARWRKKSSLMGAELDSLADLISFGVAPAACAFSLGIRTPLDQLLLTLFVLGGLARLARFNVTTGNVPKDATGKAKYFEGLPIPTSLTFSTGLVSFWLYKGWVQENIPYGTIATGTIFEFHPVVGIWLAHACCMLSKTLHIPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M3CZA2</accession>
    <name>M3CZA2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_158187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
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                <person name="Salamov A.A."/>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
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            <end position="63"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="92"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="164"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMF09979.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="176" mass="18971" checksum="0DF4B1AD72E5A60B" modified="2013-05-01" version="1">MAIRGGFLRLVMITAYAIAFCCAAIITGAFAWFLVERDNSSNIASLILGVLTLIYCAICILVTCCTAGTFLAYIGVLLDLVHIGLMMAVAIINRSATDLDSCEDFDNGRGGGGGRGGRGDRREVYSRLGRDDVDVRCGLYVAAFAVAIIAIFMFLITMVMQVLIRRGRGRKEVVKA</sequence>
</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
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    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000016931">
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF10281">
        <property type="entry name" value="Ish1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF10139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="110" mass="12066" checksum="3F171D3D279490B2" modified="2013-05-01" version="1">MSTPIDKALNSKNLFIGFAALITAATAWSVWGQDMFPAASSDSKSESANTTTQPETWSEAELRRWLKKRNLPIYDTESRKDLLKRVQNILSNLHASSPQGDAGKPASDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M3D047</accession>
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        <submittedName>
            <fullName evidence="9">HlyIII-domain-containing protein</fullName>
        </submittedName>
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            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        <property type="protein sequence ID" value="EMF09858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016906511.1"/>
    </dbReference>
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    <dbReference type="STRING" id="692275.M3D047"/>
    <dbReference type="GeneID" id="27903648"/>
    <dbReference type="eggNOG" id="KOG0748">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OMA" id="SRWTYIL"/>
    <dbReference type="OrthoDB" id="5585746at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF97">
        <property type="entry name" value="ADIPOR-LIKE RECEPTOR IZH3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
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        <location>
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            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="385"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="470"/>
            <end position="490"/>
        </location>
    </feature>
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        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="124"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
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        <location>
            <position position="468"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
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        <location>
            <position position="472"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF09858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="506" mass="56896" checksum="251C77EF7E371631" modified="2013-05-01" version="1">MTQTTYCTARSGTATITESCEEPTLGATSGAQFDTELERSRKRRRHSSYNPRSWSSERDNVQIVIDDFLSDLGKRLAMVEEYGHLKFDAGVTTVFDTLTAIHQRCMKEYDGMRESGRRRHKAFVDALEAQYKDALAKRETLEAKVQEGVNMLEEHLAALEQRAYHLREKGAMATAHQMLDSGIAYMDETAIKASHLMLEGADAARRAKEHMKMKIEVALGHARKHGVITYDMLPEPWRVNPYILSGYRFSENKLQCVTSCFTLSNEFVNIWSHAIGLIVVLAIAFWIYPSTPAFIDATAFDIVIAGAFFFAACKCLVCSTMWHAMSSISNQTLMERFACVDYTGISLLVAASIMTTEYTAFYCEPVSRWVYMSLTFALGIGGIILPWQPTFNRADMAWARVGFYVSLALTGFLPMAQLTVERGWLATLYFYAPILKSVLVYFSGAVLYAAKIPERFLPGWFDYLGGSHNIWHFAVLGGILFHYTAMQSFFGDAFRRANAPAGCSVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M3D1U9</accession>
    <name>M3D1U9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Stress response protein NST1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_127008</name>
    </gene>
    <organism evidence="9 10">
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        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May act as a negative regulator of salt tolerance.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NST1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759599.1">
        <property type="nucleotide sequence ID" value="XM_016902114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D1U9"/>
    <dbReference type="STRING" id="692275.M3D1U9"/>
    <dbReference type="GeneID" id="27899251"/>
    <dbReference type="eggNOG" id="ENOG502QSSK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002935_0_1_1"/>
    <dbReference type="OMA" id="EEDTQYG"/>
    <dbReference type="OrthoDB" id="21629at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025279">
        <property type="entry name" value="NST1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032922">
        <property type="entry name" value="SON"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46528">
        <property type="entry name" value="PROTEIN SON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46528:SF1">
        <property type="entry name" value="PROTEIN SON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13945">
        <property type="entry name" value="NST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="241"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="379"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="488"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1138"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="65"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="272"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="294"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="379"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="409"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="488"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="513"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="705"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="783"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="796"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="844"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="857"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="912"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1009"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1149"/>
            <end position="1163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU049441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF11478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1226" mass="135317" checksum="F9AF5BD5E9D79ED2" modified="2013-05-01" version="1">MATHSKAPAPSTNGVLSAPPPVGVNRKKAKRRAKQQAKSAQQLPVHHVAGQQTTEGYDEDALRYEEEEEDDYDSEADYDPSDDHHYAPHAPTNGVHPPPPPLVSSGSKRGKKKQTGSMSQGGAYDPRMLPPSMHHGENTPSSGPVSLSRPHRGSRQGDAIWHTSMQQERENIKHFWLNLTEDERKRLLRIEKEAVLKKMKQQQKHSCSCTVCGRKRLAIEDELELLYEGYYAELEQYAHHDVPPLPSSDGLVPDPLQHRRPHPLATPPPPLHHPHHAHAHTHSHHRTSQIHEVLDDEDEYSEEEEDEEEYSDEEEDEDYSDDEPEPEPEPPRGHPGVPDFFNFGTHLTVKDNLLTVADDLLKNDGRKFIEMMEQLAERRLQREQRSQYESDTHSGYPPGDPTYDHQDQMDGDEFDDEEDSYNSQEEYDDDIEEEEDLVGDMKMEGRRMFQIFAARMFEQRVLTAYKEKVAAERQQKLLDELEDDAKLQAQREAKKQRDAQKKKDKKKQQQMAKAEEKAKRDAEKAEEEAKLRAAEEKKQEEQRRRKEEQRRKREEEKKKLEEEKARKEAEKLKRQQDEQQRREETERKAREQKAAEKAKKEEQRKREREEREAREKEARERKAQDERDRKEREAKARADKDARDRERGAQQTANANHMAHPPPALAKRPSQQATVAIPGMFGKQTPSGVASPHPSVPMPAIPKASTPSKPKQASHQGSHASSPRQAQPQVPNAPSKASSPGSNGTQQAQNQPRQILQKSGAHQGNHQTQPHAGGPSPLHHQPIQPPPGMPHPQQFPPGAFGGMPPMGFQNFQGPRGPMGMPNMGQRGPMPMFPQQPPHNMGFPNGLGFGTPGMNGMGPPPGMMMPPQGRPFPFDNGPGIMGQPPPGFGQHPSHHPNHSSPVGQPPTSGIEAQRQSMSGHSRQPSSDKDRLDSAASQPIARPAPIQRPGSVRPPGPDRNGSNGDVDDLSKHLGSSALLDDSDEPCPKDRRHSSMATNPRGINIPGAGMTPMGGGFGGLNAPGTSWGNTSATPFGQSPALGGPGWGALPHQVGSWGANNAAFSNNNNHFGTFGAPISGPRGGPQTRPITVRQLLCNACRELSRSGEEYHNVDAVIQLIMSRNPPLDFAPDAAEVKDISTVEGDSRNGGGELHFREHDDGSKDIKWTQDASTPDQGGHRSSELAAIGSPAVGKSSPAFGMFGAPGTGRGSAGPPMGILQNLGAIGSSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M3D271</accession>
    <name>M3D271_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase II holoenzyme cyclin-like subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_150478</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin C subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759709.1">
        <property type="nucleotide sequence ID" value="XM_016906203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D271"/>
    <dbReference type="STRING" id="692275.M3D271"/>
    <dbReference type="GeneID" id="27903340"/>
    <dbReference type="eggNOG" id="KOG0834">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022000_7_0_1"/>
    <dbReference type="OMA" id="WESFHVR"/>
    <dbReference type="OrthoDB" id="25002at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20546">
        <property type="entry name" value="CYCLIN_SpCG1C_ScCTK2-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000072">
        <property type="entry name" value="Cyclin Pch1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0195">Cyclin</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="5">
        <location>
            <begin position="66"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="5">
        <location>
            <begin position="186"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="309"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="359"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="408"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="446"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF11588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="485" mass="53477" checksum="C1355A4CC7461C59" modified="2013-05-01" version="1">MPPPSQTQHLPPAHPATRQRPKSPNRVLAEAEAQWLFTDEELANAPSIQDGMSVEDERDRRVKGINFIVQVGIMLKLPQLTLSTASIFFQRFLMRGSLAKERNGTPKLHHFQAAATALFLATKVEESCRKMKELVLAFCRVAQKNPNLVVDEQSKDFWRWRDLILHNEDHMLETLCFDLTVESPHRQLFEMLKFYNVEHNKRLRNAAWGFVTDSNNTQLCLLVSSRTIAVASLYAACKFCEVSLPDDAKGRPWWELQHVRLKEIRRAVEYMLSNYDGSANKVDGIAVTGGSDGNSSIYAGLNTPATDGANDDWNVTRAPASASPFVPPGSEERPSDASSASGKRERDVEQPITNGNGTSHDENNSKRPKLEPHVTSGVDNPKPMHNAIPMDTTVVPDSEAPAGNTSGEVEDIKDEEDEGMRVDFGNKQAESDMDAAQTESEGVKSSLMSTETPLPQSGEDDGGRTKAPSVHAKGDDAEGSEEGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M3D317</accession>
    <name>M3D317_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Class II aaRS and biotin synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_150438</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759653.1">
        <property type="nucleotide sequence ID" value="XM_016906176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D317"/>
    <dbReference type="STRING" id="692275.M3D317"/>
    <dbReference type="GeneID" id="27903313"/>
    <dbReference type="eggNOG" id="KOG1536">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006150_1_1_1"/>
    <dbReference type="OMA" id="HHAFYSN"/>
    <dbReference type="OrthoDB" id="10250105at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin--[biotin carboxyl-carrier protein] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03144">
        <property type="entry name" value="GATase1_ScBLP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019197">
        <property type="entry name" value="Biotin-prot_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12835">
        <property type="entry name" value="BIOTIN PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12835:SF5">
        <property type="entry name" value="BIOTIN--PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09825">
        <property type="entry name" value="BPL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="2">
        <location>
            <begin position="413"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="348"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF11532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="753" mass="81334" checksum="251069F99181FEEE" modified="2013-05-01" version="1">MSSKKINVLIYSGPSTSLPSVRHATWTLRRLLGPHYAVHTLTADQLLKEPWPSTCALLVFPGGADMGYCRTLNGAGNRRIKAYVQGGGKYLGFCAGGYYGSAKCEFEVGRKGWEVVGARELAFYPGVCRGLAFPGFVYGSEKGARAVRVSTADGSFNSYYNGGGVFVDAERFADRGVEVLARFDEELAVDSGATKAAVVYCKVGDGAAVLTGPHPEFAGMNLNRNEAANPDYGKIVDALLATDEQRTDFLKTGLIRLGLQVSQEVQPVPSLSPLHLNSSDPTEISELLASWVASGLITDENGHGVIRGENDTFSLKHNDIFGTTPSVDDTLGGGSSVEGTMKKLSITSSSSSSSSSSSESNDASPQTDGATDRIPDYNSLPKTLIAHTESHPSIKESPYFKHAEYYHWLEKYRRSNGSSISGDFGRVLLYGEVVTSTQTLLEKNPSLLSQLPIGTTAVATTQVSGRGRGTNVWVSPPGSMMFSTTFKHPMALSTTAPVVFVQYLAAMAIVTAIQNTYSSSPHGSSSSPYKNLNIRLKWPNDIYALDPSTTTNPTTNNNNHPPNAYTKIGGILVNSSYSGSDYTLVLGIGLNLSHTHPTPTTSLNQLLTSCTSTSTSTSQQQHPPSNNQNDQLLFTYERLLACILPTFETLYARFCQTGWDSSFEKMYYKMWLHSGQIVTLETGEEEGAKGAQTAVTVRIEGITRDWGLLVAEEVVGGRQENGTRGVRGTGKKFLLQSDSNSFDFMRGLVRRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>M3D483</accession>
    <name>M3D483_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phosphotransferase</fullName>
            <ecNumber evidence="11">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SEPMUDRAFT_149513</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-fructose + ATP = D-fructose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:16126"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a D-hexose + ATP = a D-hexose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22740"/>
            <dbReference type="ChEBI" id="CHEBI:4194"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:229467"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:22741"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the hexokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="11"/>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF13005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761126.1">
        <property type="nucleotide sequence ID" value="XM_016905600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D483"/>
    <dbReference type="STRING" id="692275.M3D483"/>
    <dbReference type="GeneID" id="27902737"/>
    <dbReference type="eggNOG" id="KOG1369">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014393_5_2_1"/>
    <dbReference type="OMA" id="ADCVQQF"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019158">
        <property type="term" value="F:mannokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000092">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.367.20:FF:000004">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019807">
        <property type="entry name" value="Hexokinase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF16">
        <property type="entry name" value="HEXOKINASE TYPE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00378">
        <property type="entry name" value="HEXOKINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 11 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="12">
        <location>
            <begin position="27"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="13">
        <location>
            <begin position="227"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMF13005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="508" mass="56417" checksum="CC487A46BB82E832" modified="2013-05-01" version="1">MVGLGPRRQPSRRGSMADIPKDILGEIKRLEEMFTVDTSKLKAITEHFQKELAKGLSKEGGSIPMNPTWVMGFPTGHETGTFLALDMGGTNLRVCEINLPEEKGEFDIIQSKYRMPEELKTGNAEELWGYIADCLQQFIEYHHEGEKLDRLPLGFTFSYPATQEYIDHGVLQRWTKGFDIDGVEGKDVVPPFEKALEERGVPIKLTALINDTTGTLIASAYTDTEMRIGCIFGTGCNAAYMEHAGEIPKLDHMKLDPKQEIAINCEWGAFDNEHKILPRTQYDIIIDKDSPRPGQQAFEKMIAGLYLGELFRLVLVDLHEKPGIHLFEGQDISSLKKPYSLDASFLSDIENDPFENLQETYDMFYDKMKINCQKPELELIRRLAELIGTRSARLSACGVAAISKKKGYKTCHVGADGSVFNKYPHFKARGAQALKEILDWETGRDGKPLGKGHDPIEIMPAEDGSGVGAALIAALTLKRVQEGNHAGIRDAKSMLAGTAAAKPNSKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M3D4K7</accession>
    <name>M3D4K7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_86147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0696 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760935.1">
        <property type="nucleotide sequence ID" value="XM_016910404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D4K7"/>
    <dbReference type="GeneID" id="27907541"/>
    <dbReference type="eggNOG" id="ENOG502SG47">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1387249_0_0_1"/>
    <dbReference type="OMA" id="NISQEHD"/>
    <dbReference type="OrthoDB" id="10067381at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015034">
        <property type="entry name" value="Bles03"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31977">
        <property type="entry name" value="UPF0696 PROTEIN C11ORF68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31977:SF1">
        <property type="entry name" value="UPF0696 PROTEIN C11ORF68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08939">
        <property type="entry name" value="Bles03"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF12814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="197" mass="22341" checksum="D9E1C77BC1858110" modified="2013-05-01" version="1" fragment="single">MPYRDQLASNLPVHAVSTGVTTGKRMLFLGTPYLPRSWRYFDNFMDGSLTTATSEGKLGPTSEAAVYIKQNPETTVIRIHSEEFSNADDVHRVLDELVNLNVRFAECKRVYYKCDAPIHPRTFSSNSYKLRASLYSSKDILGLENKATAVAPSSRPNKRDREMADILPMFSDNISQEHDILLALLHILQRFPTMTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M3D589</accession>
    <name>M3D589_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_43896</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF13049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761170.1">
        <property type="nucleotide sequence ID" value="XM_016908906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D589"/>
    <dbReference type="GeneID" id="27906043"/>
    <dbReference type="HOGENOM" id="CLU_2948364_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF13049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="54" mass="6426" checksum="94AAFAF9D2639720" modified="2013-05-01" version="1" fragment="single">RVEYLIDLTKLFIAAIAVIRTMKGLTIYLILIYYNKLFDILEEAIKRLKNKRIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M3D5N2</accession>
    <name>M3D5N2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_148568</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761315.1">
        <property type="nucleotide sequence ID" value="XM_016905005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D5N2"/>
    <dbReference type="STRING" id="692275.M3D5N2"/>
    <dbReference type="GeneID" id="27902142"/>
    <dbReference type="eggNOG" id="KOG0825">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026721_0_0_1"/>
    <dbReference type="OMA" id="GDWYCME"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047157">
        <property type="entry name" value="PHRF1/Atg35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12618">
        <property type="entry name" value="PHD AND RING FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12618:SF20">
        <property type="entry name" value="PHD AND RING FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="5"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="303"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="303"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="326"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="403"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="423"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="468"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="486"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF13194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="592" mass="65364" checksum="C17C571731945ECB" modified="2013-05-01" version="1">MADTCIVCLGDLQQHTSRDEDPPPGAPATRIETETAGDDAKVTTKSIAKSADTDAEDVAHLLPCKHDLHHACLKPWVERANSCPICRTVFNMVEVSHAVGGPCIDSYAVQDKTQEADIDPGIIVEEDELFAVEAFEPCLICGILDDGHGVMYCDGCDKTVHVFCAGHDDAPDIWYCETCLADLENDADLPGLAAATRRGPRARNANRNANGGRAIPRRRRNNDVTWARVWQEVSRRLDLDLDFPFDEEVDERQFAAQRQEFARWQERFAVAGPNRNRLRVVAQANLQSRNEPESQEELRAWNAFEKARDSQEAPREVRRRKRRATQSPASPSEPQQPAEQPQLKRPRLRRPRATDQPESSAAAARRRGEGPTFLSSLLREVENKPASATSPATSDHALGHFSPRQTSPMHSPASSEVGCPTAITPPPHRPSSPPLSSTIIPAMSPIGATFSPFSPIAANRDDPEHGTSSRHRGRRHRGADDEDERNEASSDDRAGSHSPSRNLSYPAKEEIQRMVKVSLKPRYADKEIDKDQYTDINKSVSRKLYELVRDATALANQAERERLQGVANDEVAKAVAAFRSAPAGDTTTDASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M3D6L3</accession>
    <name>M3D6L3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_148777</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761630.1">
        <property type="nucleotide sequence ID" value="XM_016905140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D6L3"/>
    <dbReference type="STRING" id="692275.M3D6L3"/>
    <dbReference type="GeneID" id="27902277"/>
    <dbReference type="eggNOG" id="ENOG502SKCU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011237_1_0_1"/>
    <dbReference type="OMA" id="DNGWSTI"/>
    <dbReference type="OrthoDB" id="5420905at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052973">
        <property type="entry name" value="Fungal_sec-metab_reg_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="15"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="104"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="345"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="398"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="398"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="468"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="480"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF13509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="905" mass="102109" checksum="D558835E8D9CFE94" modified="2013-05-01" version="1">MDDFAAYTTHDLPFDFGGQQHLAPAHDPRPHTYPPPFGQQNSQNSHAWPLQHQHHIGQQRFEQEVVMQQQLQQHHQQQQQQQQQQQQQQYQYQQQQSQLQAHQQAQYHQQQQHQQQQHYMASQSSQDEDAKPQQLSRPNSNQSNQPISLNPNGLDMDYSAMLSTTNWQYHFQQAAAAQQQQQQQQQQQQQQQQQQQHFVAPNAQAFDNMNSYHAASFGTQLQASPVDFMPTTTVGGYAVSAAMDQTNYMTMAGPMDSMNSLVFPLEDYSAGLVFPMSLNQAALQEHTQLTQPASDSIHSSIPGSSPTGTILEVQSLSDNEGWSMVNYNSHRASLDSFGTVSNPSQNLHIRTSSDSSASDGPHSAELSGSYEEIPPWPLHSPHDLHGEGYLDAQYAAYQQHTHQQHAHSMGMHPHSSPPASAVASAAVSPQNGVVSYHSSGSSSTSPASSGPVSPPLRRRKSPVEAKTTKAVIKKTTPPATRRDASGEKKVGRRRGPLRPDQRQQAHEIRKLRACLRCKFLKKTCDKGEPCGGCRPSHARLWQVPCTRMDIKDIGYFMKDWKADYDRQVSLGFSAGNVKGYSSYERVLYITHGYGHYLPINAREVYVNDDQCFGMDWVETALGQGPEGFEISTAKLTAGMEGVSTSMLSEYLDRHLDEGFEAFVGEYFEGTKFLSEILITCYHYYLKEKTPSIRKALKLVLAYNLTLHVTMVTGLSEEEQFTGKIRDEKSRFYGQTMAPVMINFQVKCALADMWRELQKDILEELSALYSSVYSGEKLKNWPTIFMLATILLAIWEWMQFDCHYRVPDEKAVHKFCDDMETTPVGVIVGLFSAISTKLPGLQEWDTKKHHQLLGSNPAVCDALTEVRGHINKHEKYLRERSTATFDRDDFDCLSNKFLSKLVIKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M3D6S4</accession>
    <name>M3D6S4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_149008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761981.1">
        <property type="nucleotide sequence ID" value="XM_016905281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D6S4"/>
    <dbReference type="STRING" id="692275.M3D6S4"/>
    <dbReference type="GeneID" id="27902418"/>
    <dbReference type="eggNOG" id="KOG3139">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_11_0_1"/>
    <dbReference type="OMA" id="GCCALRP"/>
    <dbReference type="OrthoDB" id="41532at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052777">
        <property type="entry name" value="Acetyltransferase_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43305">
        <property type="entry name" value="FAMILY N-ACETYLTRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G01380)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43305:SF1">
        <property type="entry name" value="FAMILY N-ACETYLTRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G01380)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF13860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="162" mass="17740" checksum="BBF9CD782467D4A5" modified="2013-05-01" version="1">MMASVTITPIASSDDLAAATVLFRKYAESLGIDLHFQDFGTELRSMPGKYAPPDGALFLARNQEGEAIGCVGLRPLSSTDGLSEMKRLYVEPQGRGLGVGKLLAESVIKEATRLRYSAIVLDTLESMVSARALYQSLGFVETEAYYDTPLKKDTRFLKLVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M3D729</accession>
    <name>M3D729_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3752 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_163334</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761805.1">
        <property type="nucleotide sequence ID" value="XM_016908049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D729"/>
    <dbReference type="STRING" id="692275.M3D729"/>
    <dbReference type="GeneID" id="27905186"/>
    <dbReference type="eggNOG" id="ENOG502RXM1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067132_0_0_1"/>
    <dbReference type="OMA" id="NKAADFG"/>
    <dbReference type="OrthoDB" id="73491at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022226">
        <property type="entry name" value="DUF3752"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046331">
        <property type="entry name" value="GPAM1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46370">
        <property type="entry name" value="GPALPP MOTIFS-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46370:SF1">
        <property type="entry name" value="GPALPP MOTIFS-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12572">
        <property type="entry name" value="DUF3752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3752" evidence="2">
        <location>
            <begin position="147"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF13684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="296" mass="31935" checksum="C2C81D8FEFAADE9F" modified="2013-05-01" version="1">MSSDFAPDLPPHLLAKRKRRQEEDARDDVATASGAKRAASPDEPEKRRKIGPALPVPQDSPPAGETKSRKVAGPAPPPAPLDERPPEPLAPQADDDDDSSDDDDGFGPALPSAATATSTFANNKDDDDDQNEEPEVKVKRDEWMMMPPKQDDLAARLDPLKARPTKFAGKGASKGDTDNSTWHETPEQKQKRLQDEMMGISSKPAGGIARVEPGKSAKAKKDEVAHRLVNEQRGPSLMEQHAKTKGPEAVDDDPSKRAFDREKDMGTGGRISSSQKKQMLDKAAGFAGKFAGGSYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M3D7E2</accession>
    <name>M3D7E2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_148975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761915.1">
        <property type="nucleotide sequence ID" value="XM_016905262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D7E2"/>
    <dbReference type="GeneID" id="27902399"/>
    <dbReference type="eggNOG" id="ENOG502S22D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088979_2_0_1"/>
    <dbReference type="OMA" id="WEMDSTH"/>
    <dbReference type="OrthoDB" id="425354at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053037">
        <property type="entry name" value="Pericyclase_pydY-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38115">
        <property type="entry name" value="LIPOCALIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38115:SF1">
        <property type="entry name" value="LIPOCALIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF13794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="191" mass="21607" checksum="F86C150D804FC1E3" modified="2013-05-01" version="1">MAAPPSITIHSLSGAYDLNKTLSDSTGAMLKMQNIGFLVRQAANYSAITVHLSQYPFPEDANVVQVDQEQISTGNMKQYEPRILDGEVREREIQYWGKVRGWNKYVKLSEITQDAWLTEGWDPECSSEQGQVLLSFTESVGNGWMACQVWGFATVDGVRRHVRRIYSKKGKEEHRVRLVYDYKGDVPAATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M3D7N2</accession>
    <name>M3D7N2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_149024</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762005.1">
        <property type="nucleotide sequence ID" value="XM_016905292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D7N2"/>
    <dbReference type="GeneID" id="27902429"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_12_1"/>
    <dbReference type="OMA" id="KEIYGWR"/>
    <dbReference type="OrthoDB" id="508119at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF21">
        <property type="entry name" value="QUINATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06960)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="391"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="28"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="501"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF13884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="540" mass="59013" checksum="55C913B4E261A67C" modified="2013-05-01" version="1">MGILEKIVRNESMKDDPQEIYNWRVFVLCASACFGGMLFGMDTGIIGGVLKLDPFRKTYNLPLASENPALSANLEANIVSTLQAGCFLGAIGAGYVADRWGRRWGMMVAAALAGVGAVMQAAAEGEFGVMYVGRFVAGVGVGAASMITPLYTSENAPRAIRGALTGMYQFFIVTGVCIAFWINYGSLLHFSGTVQYVVPLALQALPAIVLLVGMFISSETPRWLARQDRWDEAARVLSRVRNLPQTHPYVQDELQEMADQLAWERRLIAGSGVGDLLKEMVMVPGNRKRALISIGLMICQQMTGTNAINYYAPQIFTNLGLTGTAPSLFATGIYGVLKMVGCALFLLLAADSLGRRRSLLWTSIAQGLCMFYIGAYIRVAPPEKGVPVPPAGYVAIVAIYLFAVFFQFGWGPVCWIYVSEIPTARLRALNVSIAAATQWLFNFVVARATPTMIATVGRGGFGAYFIYGSFCFTMFVFTFIFVPETKGRSLESMDELFGKVADGKTMDEEESRRGESHAERQTEQDQNKVMDVNVAHVEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M3D861</accession>
    <name>M3D861_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_148079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762456.1">
        <property type="nucleotide sequence ID" value="XM_016904687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D861"/>
    <dbReference type="STRING" id="692275.M3D861"/>
    <dbReference type="GeneID" id="27901824"/>
    <dbReference type="eggNOG" id="ENOG502S1YP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014331_1_0_1"/>
    <dbReference type="OMA" id="IGWAFNC"/>
    <dbReference type="OrthoDB" id="5411773at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF14335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="519" mass="57590" checksum="C8D440DDD337A091" modified="2013-05-01" version="1">MAVPATLLDQCTICMEEQLFSQGFSLLTSVLHAGLDTNAPACIPPPPHLALASTLAVHPSMTTRTDDQDKHAAANAALRYLRDVVAVVGVEHAGIREALQYGTPPALRSDRSSRAKTRRSNAGQASDEEVESGNLRSKYIEGQSVAENAQDFWAVVGWAFNCSVRHKARWERWSEWLELMLDVLEEDLERYSARGHKSPELAHSLIAQYMSIVGAGRNNKRRVMRAVLADGDARSMAEFGEIWKNETRPVKKEELLGSKRRKLDLDNDDYGDYLDNESEEDEQIKSRMSRSRTAPKSRRSRTPADLSAAKDEDDDDIALETASEGDAIAEYGGMDSIRLRQRFLSLFTNFSLVAPNLFVDTDELFAIYTEFIRPLPLSIFQQFALPLRRYLSPNLQASLNEMLFRPLLGTTSAAGLIDQAEFENSFASSAATSTSATDNAKVSLLTESMLRALWTTGTLTPNLSQLKVLVEQGVKLRHDKVAGNGRRKTGKTADAEDDARLVLEHSGQRMMVLLNVLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M3D8A3</accession>
    <name>M3D8A3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_147932</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762225.1">
        <property type="nucleotide sequence ID" value="XM_016904605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D8A3"/>
    <dbReference type="STRING" id="692275.M3D8A3"/>
    <dbReference type="GeneID" id="27901742"/>
    <dbReference type="eggNOG" id="ENOG502S5AR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055491_3_6_1"/>
    <dbReference type="OMA" id="QIWCRSA"/>
    <dbReference type="OrthoDB" id="406544at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF30">
        <property type="entry name" value="DUF636 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G03180)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="2"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF14104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="106" mass="10791" checksum="342A5FDED2723482" modified="2013-05-01" version="1">MTGSTYSTNIIVPGVEVTKGTPKTWTKTADSGNPITSHLCGECGTTLFRSGTTFGGAKVVKAGVLDGNALEEASPAVELYAKARTSWVPTISGAGQKIGMPDSADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M3DBI3</accession>
    <name>M3DBI3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_37904</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763526.1">
        <property type="nucleotide sequence ID" value="XM_016908685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DBI3"/>
    <dbReference type="GeneID" id="27905822"/>
    <dbReference type="eggNOG" id="ENOG502SPEE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_756872_0_0_1"/>
    <dbReference type="OMA" id="TFHHPSD"/>
    <dbReference type="OrthoDB" id="17262at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF1">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF15405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="366" mass="42027" checksum="62CDD703C4694960" modified="2013-05-01" version="1">MVDNHHGDNDDDDAQPLPSSVANSLLFALPREIREKIYSLCLHARDALPVEWPRPDTLRRHNPYHIQPQLLRTCRIVHSESAPLLYALNNLTFHHPSDSNVFVRALCDTAFGRRITGLSLHVKAGDIRMWMTYLTSTDPHRSLRYDFPNLRDLGLRYRSSRWNAGNSAEHNLKSWIDDSRLDELIDGVRGVYRPYWCTPQEEKSRAAEEQGLSGFDHDNDLPEPEFLTRDETVRARDRYFELRHARLERALQKDSAPLIRICCACRVHPSHFNALTDPSVAFHLQDQNLRAGVLPDAPHHLPAERVMEGSPFPANGFTSTDLQRDVKKLYDPELGSANVSRTPYVWRKGVLLALEIHSVDSRRDQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M3DBK4</accession>
    <name>M3DBK4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Elongation factor Tu</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_147172</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763365.1">
        <property type="nucleotide sequence ID" value="XM_016904130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DBK4"/>
    <dbReference type="STRING" id="692275.M3DBK4"/>
    <dbReference type="GeneID" id="27901267"/>
    <dbReference type="eggNOG" id="KOG0460">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007265_0_0_1"/>
    <dbReference type="OMA" id="EGDKEWG"/>
    <dbReference type="OrthoDB" id="2067at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03697">
        <property type="entry name" value="EFTU_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03707">
        <property type="entry name" value="EFTU_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000001">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000003">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_B">
        <property type="entry name" value="EF_Tu_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033720">
        <property type="entry name" value="EFTU_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004541">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_bac/org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00485">
        <property type="entry name" value="EF-Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000766">
        <property type="entry name" value="PRK00049.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009372">
        <property type="entry name" value="PRK12735.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009373">
        <property type="entry name" value="PRK12736.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF36">
        <property type="entry name" value="ELONGATION FACTOR TU, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="46"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF15244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="439" mass="48749" checksum="072C82FE75A070E7" modified="2013-05-01" version="1">MSFATRLLRTSRALRTQHINPIQSALNTRGQQQLVRGYATVFERSKPHVNIGTIGHVDHGKTTLTAAITKRQAEKGYAKFLEYGAIDKAPEERKRGITISTAHIEYQTDARHYAHVDCPGHADYIKNMITGAASMDGAIIVVAASDGQMPQTREHLLLARQVGVQRIVVFVNKIDAVEDQEMLELVEMEMRELLSSYGFEGDDTPIVMGSALCSLEGRRKEIGEEKIDELLKQVDEWIPTPEREMDKPFLMSVEDVFSIPGRGTVASGRVERGVLKKDSEVELVGKNATPIKTKVTDIETFKKSCDQSQAGDNSGLLLRGVKREDVQRGMVIAVPGSQKAHKKFLTSLYVLTKEEGGRHTGFQNNYKPQLFLRTADEAATLTWAEGSEQLKENKMVMPGDNVEMVCEINKPLALEQGQRFNVREGGRTVATGLITRVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M3DCT3</accession>
    <name>M3DCT3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutamyl-tRNA synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_147609</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763956.1">
        <property type="nucleotide sequence ID" value="XM_016904411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DCT3"/>
    <dbReference type="STRING" id="692275.M3DCT3"/>
    <dbReference type="GeneID" id="27901548"/>
    <dbReference type="eggNOG" id="ENOG502S0KS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085403_0_0_1"/>
    <dbReference type="OMA" id="YAQKMTK"/>
    <dbReference type="OrthoDB" id="417697at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025255">
        <property type="entry name" value="DUF4202"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41729">
        <property type="entry name" value="GLUTAMYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41729:SF1">
        <property type="entry name" value="GLUTAMYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13875">
        <property type="entry name" value="DUF4202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF15835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="22692" checksum="2A1AC21EB498389F" modified="2013-05-01" version="1">MGGNYDQARKDIYEAHNEDPTKITTPEGNEVAYESHYSEKMEKFLQKRSPQASDVLKLAICGQHFRRWEVPRSQFPMTKIGYHSWRTHLKKRQAKLVGEILEKNGYLEDDVKRCIALIEKEGLKQGEPEVQVLEDVACLVFLDDQFDEFKEKHDEQKIITILKKTWIKMSDEGHDLALEIPMTDECKALVGKALNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M3DCX0</accession>
    <name>M3DCX0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_147628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763986.1">
        <property type="nucleotide sequence ID" value="XM_016904424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DCX0"/>
    <dbReference type="GeneID" id="27901561"/>
    <dbReference type="HOGENOM" id="CLU_2160004_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF15865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="111" mass="12520" checksum="F015B0DF09D769EF" modified="2013-05-01" version="1">MLVSMMVTFWKPHGSLPGHALAPVVFMILSFRSFWHSFEMMCHRAENELEAAGRVGTFAVEDHPVLRRKTGCSVQSVVQQPVIVLSCGLPKPLLPGDFNIHLHQKEKLQTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M3DE19</accession>
    <name>M3DE19_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_147702</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764116.1">
        <property type="nucleotide sequence ID" value="XM_016904471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DE19"/>
    <dbReference type="STRING" id="692275.M3DE19"/>
    <dbReference type="GeneID" id="27901608"/>
    <dbReference type="eggNOG" id="ENOG502RXPC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041178_0_0_1"/>
    <dbReference type="OMA" id="SVHLWIL"/>
    <dbReference type="OrthoDB" id="6354873at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="5">
        <location>
            <begin position="177"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF15995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="346" mass="40763" checksum="F5FDE2F68C63602B" modified="2013-05-01" version="1">MMDRRPQDSMKSTWRGDKTQWRFPHKFLVFIDAFHSHPGQEVPIHAKTDKLPYMTEWSVHLWILLHAAWPMALQQMYISYTGHDLHWLAVFLLYTVAMQINSIHEVRLLSRLGYKYGYLDGDKHARDEVPDVGVAKTLTSLELTTSVRPMLAIFFSFQRNATALQLSPWLIVELGLYGIVLDGFFYLYHRSCHEIDSLWQYHRTHHLTKHPNPLLSSYADHEQELLEIALIPLATWAVLKYVFHLPMGFHDWWICHEYVIFAEAYGHSGLRIYSHVPSTASPLLKYFGMELIIEDHDLHHRKGWRKSQNYGKQTRLWDTLFGTCGKRIEVTEETVDMNYTFNMPLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M3DE71</accession>
    <name>M3DE71_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LDB19 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_147744</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF16070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764191.1">
        <property type="nucleotide sequence ID" value="XM_016904497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DE71"/>
    <dbReference type="STRING" id="692275.M3DE71"/>
    <dbReference type="GeneID" id="27901634"/>
    <dbReference type="eggNOG" id="ENOG502QS9U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026015_0_0_1"/>
    <dbReference type="OMA" id="MVVAEEW"/>
    <dbReference type="OrthoDB" id="3832628at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024391">
        <property type="entry name" value="LDB19_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13002">
        <property type="entry name" value="LDB19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LDB19 N-terminal" evidence="2">
        <location>
            <begin position="144"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF16070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="504" mass="55881" checksum="57660E12A824886A" modified="2013-05-01" version="1">MPSKIFGIWSSPHQLDDNSNTAGGSSSAPKYPHPHSTKTAISSALEVRRPSMDHLKRPTLFAKKHHSSEKAKSKERALSKDKHARDGAHTPASSPKPIKLGLDMESPPILMHDAPNVSSGSLISGQVQITSIVPEATLSSIIMYLESTTTTKRPVQDRCRECMTQVTDLFEWHFLRQPKTFKAQNGMYEMPFSQVIPGHIPATTHGAITSIDYQLHVRARSIDGQEIEFRRELIIRRALRPGNDKNSVRVFPPTNLTLHVTLPNVIHPTGDFNVQCRMTGITTKREETQTRWRLRKLTWRIEEHETAVSPACPAHSAKIGGEGKGIAHTHTREIGNDELKQGWKTDYSDGTIEGEFSTSINPASKSNCGMEAPNGSKITHNMTMELVIVEEWAPNKKPTQATPTGAARVLRTQFVLNVTERSGMGIAWDDEQPPMYEDVPDSPPHYPSSLPRYHSSNRLMALGMGESSRSAAQHLSPQNSPHNTEIVDYEGDLDLDVEGLSLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDD4</accession>
    <name>N1QDD4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_151406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757467.1">
        <property type="nucleotide sequence ID" value="XM_016906799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QDD4"/>
    <dbReference type="STRING" id="692275.N1QDD4"/>
    <dbReference type="GeneID" id="27903936"/>
    <dbReference type="eggNOG" id="ENOG502SHQX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021768_8_1_1"/>
    <dbReference type="OMA" id="FGLVMKW"/>
    <dbReference type="OrthoDB" id="4177236at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF55">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="78"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="311" mass="36052" checksum="B686F1528365DD71" modified="2013-06-26" version="1">MGGLLSIFRPEFTWPRPIQPRISESTPPLPYLPGKFLRRMIAPLHELLYPFSEKYCAWFDIPFDRDILQLPFGLVLKWSDRASIEEVAAMKMARAAGMPVPLVLTCGDHPNHVRRFSILMTRLPGICLNNDNEPLHPEIEQPWLSQLHSCLIAMRKWKSPYGKRICSALGTTIWSTRVPFHKMGPFETEAEMHDFLFEPQSSHAFPSKEAFETTLQLANEIRSFEHRITFTQGDLKAHNILVGDDNQLTGFLDWESGGWYPEYWEHSTAMRWGRNSWWYQVATYLGGDQYQKQVECDRALNNLTVDSYIAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDR4</accession>
    <name>N1QDR4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_111133</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757807.1">
        <property type="nucleotide sequence ID" value="XM_016900899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QDR4"/>
    <dbReference type="GeneID" id="27898036"/>
    <dbReference type="HOGENOM" id="CLU_953649_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110215" evidence="2">
        <location>
            <begin position="20"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF09686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="292" mass="32760" checksum="DCB0113B6DF72DF0" modified="2013-06-26" version="1">MKLSSVTALASYAIHGALAVTEARGSNYNDTESTNGLISVTQTQVPARNVRSESLAEPLSSLNPDEMDERNTTVASTGQPRHFARYTEPRTEHLSSIRQEDVLQEIHAKAHPEFISTTNTTTEREENKRDVQAIRTLFITPTPSTLTITPTPSDSDSDSTLTYTLPATTQNITITPTATPTPQKFYKQQQLLTETCQPDYVERCRLLPNTAWWPAGGKECFCILESHAPPLPQIPQGDEELWKNFIKIRHVPLPVQATILPDGRREGTPEKAWWIWAHREKSWWEEEQGGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDR8</accession>
    <name>N1QDR8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Zf-ZPR1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_151619</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Acts as a protein folding chaperone for elongation factor 1-alpha.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZPR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757806.1">
        <property type="nucleotide sequence ID" value="XM_016906931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QDR8"/>
    <dbReference type="STRING" id="692275.N1QDR8"/>
    <dbReference type="GeneID" id="27904068"/>
    <dbReference type="eggNOG" id="KOG2703">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024138_5_0_1"/>
    <dbReference type="OMA" id="FREVVIM"/>
    <dbReference type="OrthoDB" id="308464at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.420:FF:000001">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.420:FF:000002">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1040:FF:000001">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1040:FF:000003">
        <property type="entry name" value="Zinc finger protein zpr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1040">
        <property type="entry name" value="ZPR1, A/B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.420">
        <property type="entry name" value="ZPR1, zinc finger domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004457">
        <property type="entry name" value="Znf_ZPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040141">
        <property type="entry name" value="ZPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042451">
        <property type="entry name" value="ZPR1_A/B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056180">
        <property type="entry name" value="ZPR1_jr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042452">
        <property type="entry name" value="ZPR1_Znf1/2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00310">
        <property type="entry name" value="ZPR1_znf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10876">
        <property type="entry name" value="ZINC FINGER PROTEIN ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10876:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22794">
        <property type="entry name" value="jr-ZPR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03367">
        <property type="entry name" value="Zn_ribbon_ZPR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00709">
        <property type="entry name" value="Zpr1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger ZPR1-type" evidence="10">
        <location>
            <begin position="49"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger ZPR1-type" evidence="10">
        <location>
            <begin position="288"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="457"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="464"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="493"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00054139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF09685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="502" mass="55160" checksum="6D18C8DF3BA6F64E" modified="2013-06-26" version="1">MGIPQATDMVQTSGGQPSLAKDLFEDMGRKAEEVSNNNDEQKVVDEIESLCMNCHEDGITRLLLTRIPFFREIVIMSFSCEKCGFQNNEIQSAGQIQPKGAKYALRVEKEDDLQRNVVKSDVCAFRIEDVDLEIPPGKGQYSNVEGIIRAVKDDLESHQDARMQQMPEVGAKVAEIIRTMEDMLNGHKYPFMISVDDPTGNSTIEPRPGDAAGKWAKSEYIRTAAQNAALGLGDDVPAPGTEAPETSLRPEYHSQGLVGGDDPTAAVQANNVDQEEDIVENQVYSFPASCPGCTRPCATNMKMVNIPFFKQVVLMSTVCESCGYRSNEVKTGGEVPEKGRKITLKVSTKEDLARDILKSESAALSCPELQLRVEPGTMGGRFTTVEGIMTNIRKDLRGQAFGLEDGDADLPDGSGDSMASDSKKQWEDFFTLLGDAIEGRKEFTLILEDPLAGSYVQSLTAPEPDPKLELEDYTRTHDEEEDLGLNDIKTEGYEEDNVETTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>N1QEA1</accession>
    <name>N1QEA1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA-splicing endonuclease subunit Sen34</fullName>
            <ecNumber evidence="5">4.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_128006</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. It probably carries the active site for 3'-splice site cleavage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the tRNA-intron endonuclease family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.16" evidence="5"/>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757373.1">
        <property type="nucleotide sequence ID" value="XM_016902186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QEA1"/>
    <dbReference type="STRING" id="692275.N1QEA1"/>
    <dbReference type="GeneID" id="27899323"/>
    <dbReference type="eggNOG" id="KOG4133">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049366_0_0_1"/>
    <dbReference type="OMA" id="RTFSLEW"/>
    <dbReference type="OrthoDB" id="48041at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22363">
        <property type="entry name" value="tRNA-intron_lyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1350.10:FF:000008">
        <property type="entry name" value="tRNA-splicing endonuclease subunit Sen34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006676">
        <property type="entry name" value="tRNA_splic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016690">
        <property type="entry name" value="TSEN34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059049">
        <property type="entry name" value="TSEN34_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00324">
        <property type="entry name" value="endA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13070:SF0">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13070">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26577">
        <property type="entry name" value="TSEN34_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017250">
        <property type="entry name" value="tRNA_splic_SEN34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TSEN34 N-terminal" evidence="9">
        <location>
            <begin position="14"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA intron endonuclease catalytic" evidence="8">
        <location>
            <begin position="235"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="109"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00059865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR017250-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF26577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF09252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="331" mass="36155" checksum="85728363E78FD5F9" modified="2013-06-26" version="1">MAAVPAATAVTEPIPIYKVAHRYVLYDVNHVTYLRREHNILGVQIGTLPQASQQNVFLGLPNELMPEEARLLVEKNVAYIVDDTAEHKRNFMGNGLNEDERRAYQAALRKQGQSAALDAGKRAQDRTKAALSKQQPRPAASGDWNDIPEDMLTAGPSRKKKAPKVESAADTVDKDELLFGAPANASEGSSNIVRTTSIASSTVVPEPFGVTPTTSLPPLKSRKPDHAELPEVPISYPLYKHLHGNGYFMLPGIRFGCQYTAYPGDPLRFHAHFLGNGVDWDEEFDLLKIVGGGRLGTGVKKGFLIGGEEQKPNEEGKDASVRAFTVEWAGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1QEX6</accession>
    <name>N1QEX6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">S-adenosylmethionine decarboxylase proenzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_149598</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amine and polyamine biosynthesis; S-adenosylmethioninamine biosynthesis; S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic AdoMetDC family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759803.1">
        <property type="nucleotide sequence ID" value="XM_016905651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QEX6"/>
    <dbReference type="STRING" id="692275.N1QEX6"/>
    <dbReference type="GeneID" id="27902788"/>
    <dbReference type="eggNOG" id="KOG0788">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023050_0_1_1"/>
    <dbReference type="OMA" id="WFEESSN"/>
    <dbReference type="OrthoDB" id="1068353at2759"/>
    <dbReference type="UniPathway" id="UPA00331">
        <property type="reaction ID" value="UER00451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004014">
        <property type="term" value="F:adenosylmethionine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006597">
        <property type="term" value="P:spermine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.90.10">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048283">
        <property type="entry name" value="AdoMetDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016067">
        <property type="entry name" value="S-AdoMet_deCO2ase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018166">
        <property type="entry name" value="S-AdoMet_deCO2ase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11570">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11570:SF0">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE PROENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01536">
        <property type="entry name" value="SAM_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56276">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01336">
        <property type="entry name" value="ADOMETDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0745">Spermidine biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF11682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="520" mass="57502" checksum="AFF21A42A1859ED6" modified="2013-06-26" version="1">MVNTAIPPNYTNSPSSLSGTPHWTINRDITALDLDSSNAFEGPEKLLEVWFTESDKALPASAAPNGLKAVSQDTWKEMLDLVNCKVLSVIESGNVDAYLLSESSMFVFKHKLVLKTCGTTTLLRGLPRMLEIAVLEAGFPSVQASLPGGTTVAAKPHRVFYSRKNFLFPDQQKGPHRSWRDEVRYLDKMFLGGSAYMIGKMNGEHWYLYITGPGTELTPPSTPQGELFHTPTQQMTLPEKGRHMPENEAGDETLEILMTDLEEQNARKFYLEDASAIAQDNARSAHLARKDAISHLGVIEERNGSDPSISGNTLVTGSGSDDASFDVFAQTAKEHSDLSSEEDEPLTFGEELSTEGHTLGTVVTEACGLVDVYPASKYPDARIDSYLFTPCGYSANGVVPIPGDAENTHYWTVHVTPEPQCSYASFETNVPTRHSGRTTVDVVQQVVGIFKPGRFSVTLFEAKEGLENGNARNDRRMDRIKGYRRVDRVVHDLEGYELVFRYFERDDWKGGAPRLGEHSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1QF48</accession>
    <name>N1QF48_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin-related protein 2/3 complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_149703</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ARPC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759964.1">
        <property type="nucleotide sequence ID" value="XM_016905719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QF48"/>
    <dbReference type="STRING" id="692275.N1QF48"/>
    <dbReference type="GeneID" id="27902856"/>
    <dbReference type="eggNOG" id="KOG3155">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094365_1_0_1"/>
    <dbReference type="OMA" id="TPSKWWL"/>
    <dbReference type="OrthoDB" id="200404at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044396">
        <property type="term" value="P:actin cortical patch organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051654">
        <property type="term" value="P:establishment of mitochondrion localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1760.10:FF:000002">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1760.10">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007204">
        <property type="entry name" value="ARPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036753">
        <property type="entry name" value="ARPC3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12391">
        <property type="entry name" value="ARP2/3 COMPLEX 21 KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04062">
        <property type="entry name" value="P21-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016315">
        <property type="entry name" value="ARP2/3_P21-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69060">
        <property type="entry name" value="Arp2/3 complex 21 kDa subunit ARPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF11843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="190" mass="21637" checksum="C9648276363DD6C8" modified="2013-06-26" version="1">MPAYHSVFLDEPNQQLIGNFALLPLRTRTRGPAQQLPGLPAGTSELDIEASHESYDPLDEVLALFRANTFFRNFEIKGPADRVLIYGILYVSEALSKIKPGQTKREAEKSVMNTALETQFAIPGDAGFPLNQMFEPPRDRNEAEVLRQYVMQMRQELAVRLLARVYPDPTGPPSKWWLSFQKRKFMGKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1QF61</accession>
    <name>N1QF61_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Histone 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_49599</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone H3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758443.1">
        <property type="nucleotide sequence ID" value="XM_016909121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QF61"/>
    <dbReference type="STRING" id="692275.N1QF61"/>
    <dbReference type="GeneID" id="27906258"/>
    <dbReference type="eggNOG" id="KOG1745">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078295_7_0_1"/>
    <dbReference type="OrthoDB" id="3552471at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45810">
        <property type="entry name" value="HISTONE H3.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="5">
        <location>
            <begin position="12"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF10322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="89" mass="10309" checksum="936E2D869B9E8664" modified="2013-06-26" version="1" fragment="single">KARRRTKASIAALREIRKYQKSTELLIRRLLFSRICREITMDLATNASNSICRFQAKALLCLQEATEAFLIQEFEVSNMLAIYAKRVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1QF96</accession>
    <name>N1QF96_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_117901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760069.1">
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF11948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="122" mass="13041" checksum="2C3159655009104D" modified="2013-06-26" version="1">MAEMSGGASAEQPEAAATATAPAVPKGADPKPSFAKKVLAKQAATANKNHGHRPQVSAFGAMWKNVLLTFSELHATAFEHNSLSQAKLWEKKTLVLDVASPVFYRSDREEVIALSRRVSPKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1QG14</accession>
    <name>N1QG14_SPHMS</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_135874</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024263_3_1_1"/>
    <dbReference type="OMA" id="GYCITRI"/>
    <dbReference type="OrthoDB" id="3357002at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021460">
        <property type="entry name" value="DUF3112"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35184:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35184">
        <property type="entry name" value="YALI0C10208P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11309">
        <property type="entry name" value="DUF3112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF09488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="483" mass="53724" checksum="4FF817155892E678" modified="2013-06-26" version="1">MAAELQHRVLGGTPSPQPDVAIDITFLTLFTVCGIFNLQIFWRNKKQQRLFAFSAAVAGFCSLRIVTTSLRIAWAYDPSNVQLAMGARITTYTAAVILIVSNIWWSQRILRAQHPTFGWTMAPTLSIPICAGLCVLTIILMIMGTCIQFYVAAARAQYAARCIQQYGDIFFAILAVLPIPVLLTSALAKTHPDLKDLAEDNFGRHCITRKILVCLITATFLSTGALFRATISFAPDTQPDAPNPWYYSRTCFYVFNFALDILVLVLWMCVRIERMFIVPNGAWGPQSYGGGFIFAGEPGNEKPAMVTHSREHIIHAIKSYDTLSSRSSTIPPPSRSGSWGSARRYMSASPSLPHISSPRLGQRSSWGDDSHTRVDSAWGDDSRTGIRSVDSKENLYLRRPAPCVRCRHCASHEDVNEYTGTMYRNRPVLRFDPRSAQWISRPMSLSGPSVSQYSVRETLRPVSTIDVRMSEDASPGSFLGYAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGJ6</accession>
    <name>N1QGJ6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">S-glutathione dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_145585</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764416.1">
        <property type="nucleotide sequence ID" value="XM_016903144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGJ6"/>
    <dbReference type="STRING" id="692275.N1QGJ6"/>
    <dbReference type="GeneID" id="27900281"/>
    <dbReference type="eggNOG" id="KOG0024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_3_1"/>
    <dbReference type="OMA" id="TIGTGQC"/>
    <dbReference type="OrthoDB" id="256333at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08282">
        <property type="entry name" value="PFDH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813:SF3">
        <property type="entry name" value="GLUTATHIONE-INDEPENDENT FORMALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="9">
        <location>
            <begin position="30"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="8">
        <location>
            <begin position="190"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF16295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="386" mass="41364" checksum="46C2E8A42A740FE1" modified="2013-06-26" version="1">MSDTKMKALHYDGPYQVSVREIERPKIEHPDDVIIKITTSCICGSDLHMYEGRTSAEKGLVFGHENMGIVTEVGSGVTLLKKGDRIVLPFNVADGRCRNCEEGKTAFCTGVNPGFAGGAYGYVAMGPYAGGQAQYLRVPYADFNGLKLPPGVEHEADFALLADIFPTGWHGLVLSGFQSGESVAVFGAGPVGLMAAYSGIIRGASQVYVVDQVPERLAQAAKIGAIPINFRDGDPVEQIIKKNGGMVDRAVDAVGYQAVDKDGSKERPNIVLDQLIMVTRPTGGLGIPGLYVPSDPGAPDEQSGKGQILISFGKLFEKGLSLGTGQCNVKAYNRYLRDLIIAGRAKPSFVVSHELSLDDAPMAYEKFDKRIEGYSKVLLHPNGPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGK7</accession>
    <name>N1QGK7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WH1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_129308</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764467.1">
        <property type="nucleotide sequence ID" value="XM_016902277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGK7"/>
    <dbReference type="STRING" id="692275.N1QGK7"/>
    <dbReference type="GeneID" id="27899414"/>
    <dbReference type="eggNOG" id="KOG3671">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015385_1_1_1"/>
    <dbReference type="OMA" id="EYNQDRK"/>
    <dbReference type="OrthoDB" id="8963340at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045010">
        <property type="term" value="P:actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01205">
        <property type="entry name" value="EVH1_WASP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21762">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000281">
        <property type="entry name" value="Actin associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033927">
        <property type="entry name" value="WASPfam_EVH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000697">
        <property type="entry name" value="WH1/EVH1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00568">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02205">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00461">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00246">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50229">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WH1" evidence="3">
        <location>
            <begin position="17"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="WH2" evidence="4">
        <location>
            <begin position="560"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="118"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="176"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="260"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="282"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="309"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="350"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="404"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="452"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="530"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="576"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="601"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF16346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="642" mass="66612" checksum="04480D9BD3E2A183" modified="2013-06-26" version="1">MPSILSEEDKQTVKRTVPKASNKIHAVAVAKLYVAHPTRTRWTYTGLQGAAVLANDLVGNTFWIKLVDVSPANRGVIWDQEIYDSWSYNQDRTFFHTFELEDCLAGLSFADEKEAKQFKKKMDERERNAHKNTRNRPFASGPAQSAGAYGGGQQAYAAPEQQGGLKSKLGLGGLFGHKSHTQLQGPAQSIIPPRGVQISDSSQSTPSRSRANTSQSNDIDLSDPAVQAVLDDLLQMGITQDQIHEHSAFIKSYLEQNKATAAAQAEKQERASRAPPPPPPDAARVSPQNTGSTGRGPPPAPPPSRRKAGGASAAQRPPSPSSSPERGSSPVRRTFKVPPPLADAGAKFINASSMPGRNRAVSQSNPGPPPPPRPPKEAMEDTPPSSARFGVPPPFEGKRVIANPVPPPPPRSGGVPPPPPPRDSPAPSGVPPPPPPRDSPAQSSFGNDVHMMPPPPPPLPPPTSRPVPGPPSAPPLPPPNTANVPPPPPPLPPSNAANIPPPPPPLPPSNNSAGPPPPPPLPPTSSSGPSAPPPPPPMPGRAPGVPEDSAAALPKVVAPGRDGLLADIRGGARLKKVSEAEKKDRSQAMVPGAEAPASTSSGGGGGGGDAAQGGLAGALASALAARKSKVSHSDDEKDDDDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGN4</accession>
    <name>N1QGN4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">pH-response regulator protein palC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_75480</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the palC family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764502.1">
        <property type="nucleotide sequence ID" value="XM_016910106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGN4"/>
    <dbReference type="STRING" id="692275.N1QGN4"/>
    <dbReference type="GeneID" id="27907243"/>
    <dbReference type="eggNOG" id="ENOG502QWTM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023703_0_0_1"/>
    <dbReference type="OMA" id="PNDKEWM"/>
    <dbReference type="OrthoDB" id="10266451at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071467">
        <property type="term" value="P:cellular response to pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037505">
        <property type="entry name" value="pH-resp_palC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40463">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40463:SF1">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="4">
        <location>
            <begin position="1"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="440"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF16381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="491" mass="53908" checksum="ECB4E3A93E50EB45" modified="2013-06-26" version="1">MPFPFTLPTTSSVLLSDFFDSVTHPSLPLTATTKRSVLKDVLKKHKRLSPPARETNLPAVQNAVQGYLPYLLALNAGSGYRDVGPEKLDVEIKRVLEVEWRSILSTSLPARETPRAKLTGVHHEIAFTLSTLAYTSSLLARSQLRLLYGTDVLSSDQRTSIIATAMKHLMEAHGIHTYLLSLPSSSTSASLDSAPIDIHSSTISALASLALAEATIIVVAKDDPYTAAVSEVRNAENKDWMFKAPSIPKVRAHLYARFCLAAAEHANTASSLLSGTKIDEDLLKYATHLRSTARGKAARFLAIDAELASKTGEALAWLKGARKELGLPIEAASEDGNNRRRGLKGLKQTWQEKREDRKIESAGKEWGMDAGRLEEARVVEMLESKWDRENNTINIQIVPPWEPLLANMPSGREYHSQTAWRPMEMDQDVLVRMRAPPEPEERAFRGVEADSGDEEEEQGAKGENSNKSAAIGAFPGTGGEYSRSGTSTSYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1QH53</accession>
    <name>N1QH53_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">HlyIII-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_145742</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764636.1">
        <property type="nucleotide sequence ID" value="XM_016903241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QH53"/>
    <dbReference type="STRING" id="692275.N1QH53"/>
    <dbReference type="GeneID" id="27900378"/>
    <dbReference type="eggNOG" id="KOG0748">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023075_2_0_1"/>
    <dbReference type="OMA" id="HSQPCPD"/>
    <dbReference type="OrthoDB" id="529367at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF52">
        <property type="entry name" value="ADIPONECTIN RECEPTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
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        <ligand>
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    </evidence>
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
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    </evidence>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
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                <person name="Glaser F."/>
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    </evidence>
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        <source>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
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                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
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    </evidence>
    <sequence length="69" mass="7766" checksum="650C3F907875BF05" modified="2013-06-26" version="1">MDLTPLNNNRDDRKKEVQAAAVPDVPFQRFSSDHSQVLSTALEKTYSHTASKHAPLLGFLVRPRHAHNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1QHF5</accession>
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        <submittedName>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
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        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051531">
        <property type="entry name" value="N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792">
        <property type="entry name" value="GNAT FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00765)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF11879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="172" mass="19425" checksum="BB180A77B5D3D309" modified="2013-06-26" version="1">MNITTERLLLRPVQHDDLDGFHRLQADPQVTQWTKQGPCKTLERSEQMLDDLLVLVNISPPDQPILIHAITILLSSELVGLVGTFRPREIGFSLLPSHWGKGYAQEATRDFCTWYVKAFPAQTLFAKVNADNAASIKCLRRCGFSPATEMELSSDDAFSKDTERVTWLLRVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>N1QIE1</accession>
    <name>N1QIE1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_150489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758450.1">
        <property type="nucleotide sequence ID" value="XM_016906212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QIE1"/>
    <dbReference type="GeneID" id="27903349"/>
    <dbReference type="HOGENOM" id="CLU_921867_0_0_1"/>
    <dbReference type="OMA" id="WAKMDTG"/>
    <dbReference type="OrthoDB" id="3879263at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF10329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="302" mass="33926" checksum="F10ED38AF8531CAD" modified="2013-06-26" version="1">MADDLFASPTEMSRIPALSVHDTDGTSEEEEEEHQHQAKGHDGHLTPRPRSPHQAKRSQSSEFELEWFDDTCHEEYEWVRLPKVRDWDILSFLKHSPEQRNTANTPLTARRHDGKEVVMWAKMDTGADVNTINESTLSALLGDTAFNWKKPLSESPDLKDFHDLNLIGDQHFEPTHYVELSFHAGKNKKPFGLVPFVVVSDDAVKASQDGVPNVILGLRTLWEHYMVMVDIEYLCEADSALEVIAEKAEEEFPGGGHHIGVVKYPPVKGVPASTIRGKPGTKRRSTKITMTAEGARVQSWGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1QIF5</accession>
    <name>N1QIF5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_129814</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765091.1">
        <property type="nucleotide sequence ID" value="XM_016902311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QIF5"/>
    <dbReference type="STRING" id="692275.N1QIF5"/>
    <dbReference type="GeneID" id="27899448"/>
    <dbReference type="eggNOG" id="KOG0092">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_10_2_1"/>
    <dbReference type="OMA" id="PRTHHID"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01860">
        <property type="entry name" value="Rab5_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000611">
        <property type="entry name" value="RAB GTPase Vps21/Ypt51, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="13"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="275"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="305"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF16970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="316" mass="33616" checksum="F2D2A1AFE612006D" modified="2013-06-26" version="1">MSVVQECTAKLCRSSISASSPDDCRNTRPSSPSPSPPPTQKSAPSVFPTTNPISAKTSDYNVGRSLRANRASSPSNTESMADAPKPSSSVKLVLLGEAAVGKSSLVLRFVNNDFQPNKEPTIGAAFLTQKCQLPNRTIKFEIWDTAGQERFASLAPMYYRNAQSALVVYDITKPSSLVKARHWVAELQRQASPGIVIALVGNKLDLCEDDAPEGEQQESENAEEEDTGAVRKVSSKEAKAYADEESLLFFETSAKTGHNVSEVFTAIANAIPETSLKGPRAGAGTGTQAAISGTQNNSSVNLNTRGEDGQKEGCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>N1QIL4</accession>
    <name>N1QIL4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DUF300-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_150535</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758540.1">
        <property type="nucleotide sequence ID" value="XM_016906243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QIL4"/>
    <dbReference type="STRING" id="692275.N1QIL4"/>
    <dbReference type="GeneID" id="27903380"/>
    <dbReference type="eggNOG" id="KOG2641">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012923_5_1_1"/>
    <dbReference type="OMA" id="HAIYFQV"/>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="423"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="517"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF10419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="537" mass="60779" checksum="2EFD32149D1E9403" modified="2013-06-26" version="1">MAICNSTLQDARIEETPLSIGITFHQLGLLISAIFGLISVLVSLYLIWRHATHYLVPGEQKHIIRILFMVPVYSIVSFLSYAYYRHAVYFDVLRDCYEAFAISSFFALLCHYCAPTLHDQKEYFRRVVPQNWFWGVFGLQKCTGGEDKGILRRPRSGLTWFNVIWVGIFQYCFIRVFFTIVSVITESFDKYCEASLSPAFAHIWVLAFEALSVTFAMFFVIQFYIQLKTNIAEHKPFLKVVSIKLVIFFSFWQTIVISLLSSAKVGVLKPTDKMAYSDIQIGIPSVLLCIEMAIFACLHIFAYPWKPYSLKHNARFSTTPTYDGEISRYSGGFMGWKAILDAFNPWDIVTASARGFRWLFVGSRKRHNDPSYYMPANKLGESVEYNSASSGPVFAGTGEAATELYLPGNNRHNNHERLYGQSGQTMTHEENDSTGLLGGAQAPARTHAAYPSEPTGLDFKPSSIWQDEDTGYHPVVGSTYPHQNHPPPSHGGGISTQEQSVHPAYRGQSPQPPSSQHDYDHQQEGERWNSYDGGSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1QIL6</accession>
    <name>N1QIL6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Transketolase</fullName>
            <ecNumber evidence="4 15">2.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SEPMUDRAFT_146168</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 15">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10508"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <text evidence="15">Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="12">Binds 1 thiamine pyrophosphate per subunit. During the reaction, the substrate forms a covalent intermediate with the cofactor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 15">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the transketolase family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="4 15"/>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765192.1">
        <property type="nucleotide sequence ID" value="XM_016903494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QIL6"/>
    <dbReference type="STRING" id="692275.N1QIL6"/>
    <dbReference type="GeneID" id="27900631"/>
    <dbReference type="eggNOG" id="KOG0523">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009227_0_0_1"/>
    <dbReference type="OMA" id="ADYMRGS"/>
    <dbReference type="OrthoDB" id="10267175at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07033">
        <property type="entry name" value="TPP_PYR_DXS_TK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000003">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000003">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000004">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055152">
        <property type="entry name" value="Transketolase-like_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005478">
        <property type="entry name" value="Transketolase_bac-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049557">
        <property type="entry name" value="Transketolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033247">
        <property type="entry name" value="Transketolase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00232">
        <property type="entry name" value="tktlase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522">
        <property type="entry name" value="TRANSKETOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522:SF2">
        <property type="entry name" value="TRANSKETOLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22613">
        <property type="entry name" value="Transketolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 13 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 13 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12 15" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="16">
        <location>
            <begin position="356"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="418"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="117"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="476"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="480"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="527"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="14">
        <location>
            <position position="29"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="14">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMF17071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="685" mass="74786" checksum="5840E1CCBB202499" modified="2013-06-26" version="1">MPYDKTDERAINTIRTLAVDATFAANSGHPGAPMGMAPVAHVLFNKFMTFNPKNPKWLNRDRFVLSNGHGCMLQYALLHLFGYDLSIDDLKAFRQVDSKTPGHPESHDTPGIEVTTGPLGQGFTNAVGLAIAQAHTAAVFNKPGFELINNYTYTFFGDGCAMEGVASEAASTAGHLQLGNLIAIYDDNHISIDGDTKCAFTEDVTKRFEAYGWHVQWVKDGDNDLEGIEAAIKKAKEVTDKPSMIRLTTTIGFGSVLQGTGGVHGNPLKEDDCKQVKEKFGFDPSKSFAVPQEVYDQYHKHAAEGAAAEQEWNQLLEKYCSEHKELGADLKRRLTGKLPEGWQNKLPVYKPADKAVASRKLSESVLEAIYGAVPELLSGSADLTGSNNTRWKSAVDFQPPSLGIGEWSGRYLRYGVREHAMAGIMNGLAAYGTLIPAGGTFLNFVSYAAGAVRLSSLSRQRVIYIATHDSIGLGEDGPTHQPIETLAHFRALPNMMVWRPADGNETSAAYYVALTSQETPSILALTRQNLPQLEGSTIENGIKGGYVASEVEGAQITLVSTGSEVSLCLEAAKYLKEKNGVTARVVSMPCMEVFDAQPKDYKLKVIPDGIPSLSVEVMSTMGWEKYSHEQFGLNRFGASGPYKEVYAKFEFTPEGVAKRAVATIDFYKEVKPLRSPLNRAFQQLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJ79</accession>
    <name>N1QJ79_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_103739</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764468.1">
        <property type="nucleotide sequence ID" value="XM_016900514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJ79"/>
    <dbReference type="GeneID" id="27897651"/>
    <dbReference type="HOGENOM" id="CLU_1723476_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF16347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="152" mass="16782" checksum="ADE2CA2D6E58C44A" modified="2013-06-26" version="1">MSDNNNNDDERKDEIPPPLDNPNPTNPTESSHPPKPPSKPFFLLPSILLITTIIIIIILSAVYYHSQNTSSNHPHSKSSWWWSQWGLTSSYSGNNNGGAGYGYGEVESWSDEELESDLKPKIELELGHGDLRGGGGGVGRLEGGRRRVRSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJX7</accession>
    <name>N1QJX7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Glycoside hydrolase family 16 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_146509</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKN1/KRE6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765626.1">
        <property type="nucleotide sequence ID" value="XM_016903698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJX7"/>
    <dbReference type="STRING" id="692275.N1QJX7"/>
    <dbReference type="GeneID" id="27900835"/>
    <dbReference type="eggNOG" id="ENOG502QR13">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010811_4_1_1"/>
    <dbReference type="OMA" id="LPACTCK"/>
    <dbReference type="OrthoDB" id="412647at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02180">
        <property type="entry name" value="GH16_fungal_KRE6_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005629">
        <property type="entry name" value="Skn1/Kre6/Sbg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361:SF1">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03935">
        <property type="entry name" value="SKN1_KRE6_Sbg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="11">
        <location>
            <begin position="256"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="662"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="31"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF17505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="692" mass="76521" checksum="F3D18D9A5CF25A5C" modified="2013-06-26" version="1">MDRHNPPRIQVHSSNDALLDLGQPAGAASRPQLTPRQPSSRSLTQPGRPGTTQTLRNAASGNSLYSSAAPAESSELLLPPRKTQMRRFRDEDSPMRSPSENGFNSRRTSWSSESAGSRDSRYGGPFVSPFDDSRAPSRAGSDDGVTTQTVSEKFNILPGAGLLLFPEDVEKDDYLHNPDPNDKDGRLVCADLFSKRGFVNVGGLALITIGILILFIGYPILTFVQSKIDPSNGACSRDPDCISDQRPLLSNLRQSVIDPDTPDSVKTRKGDNGKQQTLVFSDEFNKPGRTFYDEDDPYFQAMDFWYGVTMDLEWYDPDAVTTEGGTLNLKFDAFQNHNLNYRSGMIQSWNKLCFKGGYLEASISLPGRGDTIGFWPGFWSMGNLGRPGFAATTDGMWPYSYHDKCDVGITPNQSDPDGLSYLPGMRLPACTCNGEDHPSPGISRSAPEIDAIEASVEYLQPPLGAAVGSASQSFQVAPFDVFWQPQADWMEIYDYSVTEANAYQGGQFQEAVSALSTLNNDWYDGKAYQTYAFEYEPGAGGYITWYIGDEPTWKMEGNAIGPNGNIGQRVVPQEPMTIIANFGMSNSFSAVNLTGLAKLFPATMRIDYIRIYQQEGDELTCDPIGYPTTDYIKNHPEPYANINLTHWEQADYSFPQNSFMHGCSSDSKPKGKKSKRSSGTPAGEWWRSWFWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1QK16</accession>
    <name>N1QK16_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">pyridoxal kinase</fullName>
            <ecNumber evidence="2">2.7.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_150853</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyridoxine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.35" evidence="2"/>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759020.1">
        <property type="nucleotide sequence ID" value="XM_016906438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QK16"/>
    <dbReference type="STRING" id="692275.N1QK16"/>
    <dbReference type="GeneID" id="27903575"/>
    <dbReference type="eggNOG" id="KOG2599">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046496_0_0_1"/>
    <dbReference type="OMA" id="WEGLKQS"/>
    <dbReference type="OrthoDB" id="2104723at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008478">
        <property type="term" value="F:pyridoxal kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009443">
        <property type="term" value="P:pyridoxal 5'-phosphate salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01173">
        <property type="entry name" value="pyridoxal_pyridoxamine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004625">
        <property type="entry name" value="PyrdxlKinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00687">
        <property type="entry name" value="pyridox_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534:SF2">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyridoxamine kinase/Phosphomethylpyrimidine kinase" evidence="8">
        <location>
            <begin position="119"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="323"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF10899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="374" mass="40654" checksum="375A46A196A26F92" modified="2013-06-26" version="1">MTDTSDLDVPETHVLAVASHVTSGYVGNTMATFCMQTLGCEVSAIHTVNYSNHVAYRAFKGRKSTPSEVADLYAGLQETRLDDFDMMLSGYCPSAALVEEVGKIARKQKLASSTKPGSFFWVLDPVMGDNGRIYVAEDTVPEYKSLLKDADLVLPNQFEAELLSEIKIRDLGSMRDAIAKLHEKGCPNVVVTSIRLPASTSAGEEEGQKSDGQQAMLSVIGSTATSTGTPRLFRVTVPALPVFFSGTGDMFAALLVARLREAAQAGNVLDRPSWKSEDHVKGCELPLAKATEKVLASMGAVLKDTARHYEAVKRSLDAPPEMNEGKGEAGEKARETERHLRLTRAAEVRVVRNARVLREPPNLELFKAEEVLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1QK17</accession>
    <name>N1QK17_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoribosyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_34717</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765666.1">
        <property type="nucleotide sequence ID" value="XM_016908581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QK17"/>
    <dbReference type="STRING" id="692275.N1QK17"/>
    <dbReference type="GeneID" id="27905718"/>
    <dbReference type="eggNOG" id="ENOG502SH5I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012235_1_0_1"/>
    <dbReference type="OMA" id="GHFMFWP"/>
    <dbReference type="OrthoDB" id="5416609at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036424">
        <property type="term" value="F:L-phosphoserine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050582">
        <property type="entry name" value="HAD-like_SerB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344:SF20">
        <property type="entry name" value="URACIL PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13207">
        <property type="entry name" value="AAA_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12710">
        <property type="entry name" value="HAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="1">
        <location>
            <begin position="473"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF17545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="674" mass="74643" checksum="077A67A8BD1EC738" modified="2013-06-26" version="1">MADTRSANEKPLHPPPVKPMIIGVFGVTGSGKTTLMHNLEASMNLSKIAFFEGSEVVARHAGGLQTFKSSNEGEKLAIREAAIISIQQDCIDTKRLGIVTGHFSFWREEADADLEEVITNADLNVYTHVLYLDPPADVIEKRVENDTNRPERRRLSAAQIRRWQDSEKKKLRKLCYKNGIVFSLIQETCAASYLVKRFYVHNEEYDKIMAIGRVIEAMSSLVGLKRTKPDAMLVIDGDKTLAAEDTGELFWKQAMSDQPDPLQALFRTAGYSHTSFHQAILLYRDVGDEEYFDAICSTVASQVTVRPEFINLLQMVAKAPHIGAIVVTCGLRLIWQKVLTNLGLSEIVRVVGSGPELSDCIVTPRIKADVVKHLQESHNMYVWVFGDSPLDLPMLKQADQALVVVGEQQKRSKSMEVELKHAIDDGDLRARQILFPGNASPLLDTSKLPIVQLVDLGFMQALKCGIQTKDATTRTAAKLLMTPTRDATVSGPALRKAHRKVGWYLATEFLSDLLGVQEIQIRHVQGGSTNGYCLVDESSTTIIAVMRGGEPMAFGVSDAFPQSAFLHAHKPEDIELQQLKRQSTVILVDSVVNNGETMADFVQHLRKLRPTIRIVVVTGVVQADGLRPGALLEWALVGYSSIDLVTLRISQNKYTGRGGTDTGARLFNTTRLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKC2</accession>
    <name>N1QKC2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Na+/solute symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_56363</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764838.1">
        <property type="nucleotide sequence ID" value="XM_016909397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QKC2"/>
    <dbReference type="STRING" id="692275.N1QKC2"/>
    <dbReference type="GeneID" id="27906534"/>
    <dbReference type="eggNOG" id="KOG2348">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010778_2_1_1"/>
    <dbReference type="OMA" id="CKRALKP"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015489">
        <property type="term" value="F:putrescine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015606">
        <property type="term" value="F:spermidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015204">
        <property type="term" value="F:urea transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11476">
        <property type="entry name" value="SLC5sbd_DUR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1730.10:FF:000006">
        <property type="entry name" value="Urea active transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031155">
        <property type="entry name" value="DUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154:SF4">
        <property type="entry name" value="UREA ACTIVE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="287"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="356"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="404"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="493"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="577"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="607"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="670"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="674"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF16717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="700" mass="74975" checksum="79DEF440B9C89D62" modified="2013-06-26" version="1">MPAKPVLSQSTGYGLIIGLGFLFAFGMMLCTFVLRRYNNELNTSEVFSTAGRTVKTGLVSAAVVSSWTWAATVMQSSAIAYQYGVSGPFWYASGATAQILLFATLAIELKRKAPNAHTFLEAIRARYGGATHGVFITFGLLTNVLVTAMLLTGGSAVASALSGVPTAAACFLLPVGVVLYTIFGGIKATFLTDYVHTIVIMVVLFLFAFTAFATSDKLGSPGAVWEALTEAGKRHPVDGNAGGSYLTMKSRDGGIFFLINLTENFATVFLDNGYWNKAIAASPAHALPGYVAGGLAWFAIPWLAATTMGLSALALENNPSFPTYPNRMDPADVKAGLPLPYAAVALLGSKGAAATLVLVFMAVTSAMSAELIAVSTICTYDIYKAYINPQASSKSLIRVSHLSCIIYSICMAAISTGLYYGGISLGYLYLLMGVIVSGAVIPATATLFLTNQSWAAATFSPPLGLVCSIISWLSHAKSAYGYVNLESTGDQNVMLTGNLVSLLSPLLFIPVLSLVFKSPKYDWKTMGYIRRDDDSDLLQNDLEQVDDDHDASNPSAPTSRSIAEAERKQLDRSVKTAGYLTIGLSLATLILWPMPMFGTGYIFSKKFFTGWVVCCFLWLFCSAICVGIYPLWEGRETCARTFKAIVRDLRGGGRVKPSNMTVTHGEVVNVAGEKGGEERESEKEDEKHTSETPPHVELAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKE8</accession>
    <name>N1QKE8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable Xaa-Pro aminopeptidase P</fullName>
            <ecNumber evidence="5">3.4.11.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Aminoacylproline aminopeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Prolidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">SEPMUDRAFT_46181</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.</text>
            <dbReference type="EC" id="3.4.11.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.9" evidence="5"/>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760396.1">
        <property type="nucleotide sequence ID" value="XM_016908987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QKE8"/>
    <dbReference type="STRING" id="692275.N1QKE8"/>
    <dbReference type="GeneID" id="27906124"/>
    <dbReference type="eggNOG" id="KOG2413">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011781_2_3_1"/>
    <dbReference type="OMA" id="EPGMILS"/>
    <dbReference type="OrthoDB" id="9995434at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01085">
        <property type="entry name" value="APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.350.10:FF:000010">
        <property type="entry name" value="Probable Xaa-Pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.350.10:FF:000003">
        <property type="entry name" value="Xaa-pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000007">
        <property type="entry name" value="Xaa-Pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033740">
        <property type="entry name" value="Pept_M24B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032416">
        <property type="entry name" value="Peptidase_M24_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050422">
        <property type="entry name" value="X-Pro_aminopeptidase_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763:SF6">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16189">
        <property type="entry name" value="Creatinase_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16188">
        <property type="entry name" value="Peptidase_M24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 19" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="9 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase N-terminal" evidence="17">
        <location>
            <begin position="9"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24" evidence="16">
        <location>
            <begin position="328"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24 C-terminal" evidence="18">
        <location>
            <begin position="559"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF16188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EMF12275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="622" mass="69395" checksum="95ADAD9FD1EFCC22" modified="2013-06-26" version="1">METVNTTDRLQALRHLMSQHKVDLYIVPSQDAHSSEYIAPTDARREFISGFSGSAGTAIVAQDRAALATDGRYFNQASHQLDSNWTLLKQGLQDVPTWQEWTLEQAEGGKTVGVDPTTITAPEARKLAEKIKKKGGKGLVAIAENLVDKVWAKDKPARPNEPVRVLEMQYAGKKFQEKIEELRKELDKKKAAGFVVSMLDEIAWLFNLRGSDIPYNPVFFSYAVVTPTTTTLYVDETKLPDNAKAHLAGIHIRPYDDIFSDIATLAAETPTTDGEGKADAMAKKKKKYLISTQASWALQRSLGGEENVDEVRSPIGDAKAIKNTVELEGMRQCHIRDGAALIEYFAWLEHQLVVEKVEVDEVAGADKLEAIRSKHDKFAGLSFDTISSTGPNAAVIHYKPEPGSCSVIDPNQVYLCDSGAQYYDGTTDTTRTLHFGTPDAKEIEAYTLVLKGNIGLELAVFPKGTSGLALDTLARQYLWQNGLEYRHGTGHGVGSFLNVHEGPIGIGTRPQYSEVPLSVGNVISDEPGYYEDESFGVRIENVIMVKEVKTKYNFGDKAYFGFEHVTMVPHCRRLTDISMLTKIELDYINAYHKEVWEKTSPFFKNDERTLKWLERECQPYEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKM7</accession>
    <name>N1QKM7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribonuclease_3-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_15066</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760456.1">
        <property type="nucleotide sequence ID" value="XM_016906320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QKM7"/>
    <dbReference type="STRING" id="692275.N1QKM7"/>
    <dbReference type="GeneID" id="27903457"/>
    <dbReference type="eggNOG" id="KOG1817">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1998080_0_0_1"/>
    <dbReference type="OrthoDB" id="2392202at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207:SF0">
        <property type="entry name" value="RIBONUCLEASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="RIBONUCLEASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNase III" evidence="2">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF12335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="125" mass="14221" checksum="E95FFAA5D7F5741E" modified="2013-06-26" version="1" fragment="single">TSDLTYERLEFLGDAYIELFASRLIYESYSHLPAGRMSQVRELLVKNETLAELSRRYGFDQNIAVGAEIGELLRDSRGRGNKGYNKIVGDVFEAYVAAVVLSDFEGRGFEKAEGWCRDLWEAKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKX5</accession>
    <name>N1QKX5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cercosporin MFS transporter CTB4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cercosporin toxin biosynthesis cluster protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_112969</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">MFS transporter; part of the gene cluster that mediates the biosynthesis of cercosporin, a light-activated, non-host-selective toxin. The perylenequinone chromophore of cercosporin absorbs light energy to attain an electronically-activated triplet state and produces active oxygen species such as the hydroxyl radical, superoxide, hydrogen peroxide or singlet oxygen upon reaction with oxygen molecules. These reactive oxygen species cause damage to various cellular components including lipids, proteins and nucleic acids. Responsible for secretion and accumulation of cercosporin, but does not play any roles in self-protection against the toxicity of cercosporin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the major facilitator superfamily. CAR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765068.1">
        <property type="nucleotide sequence ID" value="XM_016901007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QKX5"/>
    <dbReference type="STRING" id="692275.N1QKX5"/>
    <dbReference type="GeneID" id="27898144"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_11_5_1"/>
    <dbReference type="OMA" id="PMMLSCW"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF48">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G02700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="300"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="375"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="455"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="480"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="524"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="548"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="146"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00053977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00069139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00077167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF16947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="595" mass="66678" checksum="29FFD48E84796F60" modified="2013-06-26" version="1">MTSKEDESRRPSSQLAETRSSSSLSSSFSMKDYEKKHDGQADTTNSHPPPPPPPPSSTSLPPLAKPHTLELDPVDAVNLPYRTVTVEAQDRLREYTEETATGLQPVVSMKRTRTGELQSEKYELVTFVENDAENPKNWSKAYKWWCTMVVAITCFAVAFNSAVITADPAGPAETFGVSEEVSLLATTLFVLGFGLGPMVFAPLSEILGRRIMYASTLLVAVVFIIPCAVADNIATLLVCRLIDGIAFSAPMTLVGGTLADCWKSEERGVPMAVFSAAPFIGPAVGPLVGGFTADHLGWRWLYWLQLILSGFCYIFITFTLPETYAPTILKRRAKKMRKETGDEKYVTEMDLDLRPVSERLRVFLLRPFQLLFQELIVFFISLYMSVLYGLLYMFFIAYPIVFQEGKGYSASITGLMFIPLALGVIMSAICSPWVNKHYLKQVERYNGRPPAEVRLIPMMWSCWCIPVGLFIFAWTSYPRLTWFGPAFGGWFVGFGFIFLYNSANNYLVDTYQHQAASALAAKTFLRSIWGAATVLFTIQMYHRLGDQWASSLLAFIGLACCAIPYLFYFFGAQIRARSRFAYAGDEENHTMDIYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKY9</accession>
    <name>N1QKY9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AstE_AspA-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_46654</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759942.1">
        <property type="nucleotide sequence ID" value="XM_016909004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QKY9"/>
    <dbReference type="GeneID" id="27906141"/>
    <dbReference type="eggNOG" id="ENOG502SKWV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035605_0_2_1"/>
    <dbReference type="OMA" id="GRTNMLH"/>
    <dbReference type="OrthoDB" id="3626597at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06251">
        <property type="entry name" value="M14_ASTE_ASPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055438">
        <property type="entry name" value="AstE_AspA_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053138">
        <property type="entry name" value="N-alpha-Ac-DABA_deacetylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37326">
        <property type="entry name" value="BLL3975 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37326:SF1">
        <property type="entry name" value="BLL3975 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24827">
        <property type="entry name" value="AstE_AspA_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110935" evidence="5">
        <location>
            <begin position="18"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Succinylglutamate desuccinylase/Aspartoacylase catalytic" evidence="6">
        <location>
            <begin position="78"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF11821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="368" mass="39568" checksum="C26773D042FE13F0" modified="2013-06-26" version="1">MRPIIALLSALTSGVTAATVYTGDRFQGHPIISSLDVNDLPSNTVSRFWLSPAAGQGGLYYFLPIFVARGTAESLESGRKLSLSASIHGDELNPVAIVQTIFRQLNETVAAGAFNGTVIGIPTLNPQGNFLNQRNFFTSSSNGFFYDMNRLFPGLSMAEGGNLVESYTAAIWNDIWGNTSNVDIAVDFHTLSTGSVGPLWAYADYASEGVQRMAELLQPDVIKIDPGLPGTIETSWVQAGVPAITVETGPANNWNRTLIKRTVDFAFRLMDDLMMTGGALPVPDLSQTFIANNFSDPYTDFSGWFESDIEILQDVEEGQVIGRVYNAWGDELQTITSSVSGRVLTVLVDPAVEAGASLATIAYNATSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1QL65</accession>
    <name>N1QL65_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Vacuolar protein sorting-associated protein 26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_146881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS26 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF18001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016766122.1">
        <property type="nucleotide sequence ID" value="XM_016903934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QL65"/>
    <dbReference type="STRING" id="692275.N1QL65"/>
    <dbReference type="GeneID" id="27901071"/>
    <dbReference type="eggNOG" id="KOG3063">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031077_1_1_1"/>
    <dbReference type="OMA" id="FKWKFSS"/>
    <dbReference type="OrthoDB" id="3821113at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0170071">
        <property type="term" value="C:CROP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030906">
        <property type="term" value="C:retromer, cargo-selective complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140318">
        <property type="term" value="F:protein transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.640:FF:000004">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.640:FF:000010">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028934">
        <property type="entry name" value="Vps26-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12233">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 26 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03643">
        <property type="entry name" value="Vps26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF18001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="312" mass="36354" checksum="92499EC6E8613219" modified="2013-06-26" version="1">MSIFSFSTPLDIDIVLDSTDDRPTVDVKLDKSRREKCPLYLDGETVKGAVTIRPKDGKRLEHTGIKVQFVGTIEMFFDRGTHHEFLSLQTELAAPGELQHPVTLPFSFKNVEKPYESYHGINVKLRYFLRVTVSRRMADVVREKDLWVYSYRQPPETNSVIKMDVGIEDCLHIEFEYSKSKYHLKDVIVGRIYFLLVRLKIRHMELSIIRRETTGVPPNQYNESETLVRFEIMDGSPSRGETIPIRLFLGGFDLTPTFRDVNKKYSTRYYLSLVLIDEDARRYFKQSEIVLYRQAPENSELAQRQAKEIQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>N1QLL0</accession>
    <name>N1QLL0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Hybrid PKS-NRPS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_164461</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760307.1">
        <property type="nucleotide sequence ID" value="XM_016908116.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.N1QLL0"/>
    <dbReference type="GeneID" id="27905253"/>
    <dbReference type="eggNOG" id="KOG1178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_37_5_1"/>
    <dbReference type="OMA" id="ETDVHHA"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009403">
        <property type="term" value="P:toxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05930">
        <property type="entry name" value="A_NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19532">
        <property type="entry name" value="C_PKS-NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF20">
        <property type="entry name" value="HYBRID PKS-NRPS SYNTHETASE APDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23297">
        <property type="entry name" value="ACP_SdgA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="11">
        <location>
            <begin position="13"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="12">
        <location>
            <begin position="951"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="2396"/>
            <end position="2474"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="3573"/>
            <end position="3649"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="8">
        <location>
            <begin position="951"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1102"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2486"/>
            <end position="2564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="3536"/>
            <end position="3574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="3942"/>
            <end position="3962"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="3998"/>
            <end position="4023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="2487"/>
            <end position="2496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="2518"/>
            <end position="2532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="3546"/>
            <end position="3568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="3999"/>
            <end position="4019"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="8">
        <location>
            <position position="983"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="8">
        <location>
            <position position="1161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF12186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="4068" mass="448109" checksum="9BA12A36E6202F24" modified="2013-06-26" version="1">MSMEVEVTETVRIRPIAIVGTACRFPGGASSPSKLWELLSQPFDVLTNPPPERLNLSRFYHENGEHHGSTDVQGRAYFLSEDIRLFDAAFFRINPKEAEGMDPQQRILLETVYEALEAAGYPLEAVSGTRTSVHVGVMNADYTDIQSRDPETMASHHATGTTRSMLSNRISYFFNFKGPSVTVDTACSSSLVALHQAVQGLRSGDATVAVAAGANLILDPAMFIAESSLHMLSPDSQSRMWDKSANGYARGEGFAAVILKPLDRAIADGDPIEGVLREICVNSDGRSEKGITNPNSLAQTALIRETYRRAGLDITEDRCQYFECHGTGTLAGDPVEARAIRDAFFPISQEPRESPRIPMYVGSIKTVIGHLEGCAGLAAVLKALGAIKHRTIPPNLHFHELNPDLLPFCQNLEVVTEALPWPEPIKPTSPLRVSVNSFGFGGTNAHAIIEEYHPTEEDTRSRMPHNEQAVFIGPLVVSAQSEKSLVSSVATLVEHIRSHPDMDLEEVAWTLQSRRSVLEHKAFFSGSTRDRLLHFMDRFVAESGGSSVIVPQKRPNTEEPGILGVFTGQGAQWASMGRGLALRSSAFRQCIKQCEETLNALQDPPAWSLYEEMMAEESASRVAEAAISQPLCTAIQIGLVELLWKANIALNAVVGHSSGEIAAAYAAGVINQSAAMQIAYYRGFHAKLAAGAQGQSGKMMAVGMSYGEALDFCSSSPFHGRIAVAASNSPSSVTLSGDKDAIEEAKSRLDDEKIFARVLHTDTAYHSHHMAPCSMPYLASLVACNIEVSEPRSDCTWISSVYGEVYASEFSRLKDQYWVDNMQNPVMFSQAIETSIWNGGPFDLCLEIGPHPTLKGPAEQTFKAALGVAPAYAGVMRRGDDEVEALSGALGFLWSQLGPEHVSFDDYRAAFDLFTPLSVPSLPSYSWDHQQPFWRESRISRRYRLGQDSFHELLGRRAPDDSDDSPRWRNILRNGEIAWLKQHVFQGQILFPGAGFVVMALEAARQLAGDRTVALFVLEDIVLSRAIVIPPGSMGVEVIFSCDMTEQSSSKEILAANFAISFCSEETSHLGLTRACHGRMRVHLGQPSCNVLPARSAQASSMVHVDTGRFYTSMAKVGLDYRGLFSGMRSATRALDIATISASWNQSHVGREYMIHPGVLDVAFQALYVAFSSPASGHIWAPYLPVHISKFSLSPAALRASPDTVDLDMDAFVETATSTLLAGDISVYQTGGQDALVQVEGIAMQAVSEPAPENDKVMFSSTVWTQDITSGPSELAQEPDDDALVQALDRVSLYYWHKLIRELSEDDILRCNWYHRHMLKVANKAVQATRNQQHPITKSEWLLDSEETITEVIERYQNRADMRLICAVGENLEDVLTKDKHVLEVMLQDDLLNRFYLEGYGFATINRALSGTVQQIVTKFPHAKILEIGAGTGGTTRSILDAIGQKYSTYTYTDISPGFFSKAAETFSDSSDKMEFKVLDIENDVAGQGFERGEYDIVIAANVLHATRCLQETMCNVRSLLKPGGYLVMMEITGLEVLRTQFIMGALPGWWYGAAEGRDTSPAISELAWHELLRDANFSGVDHILHDMQDTPRHSFSLILSQATDATIDMIREPLLGLQRVEIPPNLVVVGGKNLAGVRIVGEIQKILSPWKSCITILKDVDEFVQSPPPLQSCVLVLQELEKPLFDSNITETRLQALQTLFGTAKMILWTTSGRFSASPASNMVVGMGRSLATEIPDLVLQYLDLDSNHRTPAGDARNIVNAFFRLYFTTFSHHSTDSDRLWTVEPEIRMIGDEVWLSRVQPHRNLNDVYNAERRCITHQVAPRRDCVELISGAGGLELQLMPPGLPETQSTDTVRVQVEYTVLLVASATQSVYLVYGVMAESEQMVLALSQHNASLLHISKHKLVTLDQDAAMVATTQLFAIGIQFMSLVLQDWVPSNGSIMFHEIPQALAVAMASNSEKAMHGWVFTTCDDQRPVDLYTRLHPASTRRQLKKSLPANTTGMISFSDRPDLNIVSLMSPNCEHLTVDGFAALLNSENHIRHLQTAVKSAPASSGARDSGDLHIIRADDIGAASMKAMSLCTITDWTDARSLSVRMSGLCTANMFSSSYTYLLVGMTGEIGLSLSRFMVTNGARHIVLASRNPNVSPAWLDNMRQEAGVNVQVVQMDVASKGSVECALDKVRSSMPRIAGVCNGSMVLSDKLFLDMDVQSLETCLRPKVDGSRILDEALGREEPLQFFILLSSLASIIGNGGQSNYHAANMFMSSFAAGRREKGLAASTLHIGLVTDIGYVARAGVMMEERLRKLFFMPLSESDLHHAFAQAVRAGEPDSGQEADIIIGLESFTKSETATVRPPWERNPQFSHFVHFDTTPKQHSLVDFGQVNTKQRLDAADTDATRLSIIEECFSRKLEMMMQLRPCSVNVNVPLIDLGCDSLLAIEIRGWFLKELQVDLPVLKVLSGDTISELCSEATKRYLASKLVSVDKPASSAEASSGDSSHGDEVDSSSSGEGQARDDSKCGSTRATSDTDISRPSSPPDTPASKPEPLADPAPDPDRVQSSAPLSKQCHASHAQSRLWFLSQYLSDRTTYNVTVAYEIRGRVNLEQLRLALIQVFNRHGSLRTRFFSDEHDTLMQGVLAAFAWEPQMIMSGTDDMARDEFERMKTTVWDLSNGRTFGATVISMDSTRTMLIFGYHHIVLDGVSWHIFLRDLDHAYQSKRLPLCLDYCDYSEEMLRSSRVGAYDEDIAFWRLQHSRLPDVMPLLPTACVAERQALHHYDSHITSYRLDVDACRKIKQASMRLRATSFHFHLAVIQTILARSLDRSDLCIGIADANRTDDRYSNTVGFFLNLLPARFDVQKDHSFGELVRKTSKTVFAALSHSSVPFDLILDALKVPRSPKHNPLFQVAVNYRMGDVMQRDLGDCSLLFSSAQDARNPYDFSFNITEQSDGTSLLEVMAQKQLYSSTASQSLLDTYVDLLDQVSSDSSILVKECSIVRQSAVSRALELGRGPRMQFDWPATLSLRFDDMAVQHADDPAVIDGGAGTNISYADLKIRVDLLATAILESGAPPGTRVAVLCRPSQAVIVSMLAVLQSRMVYVPLDPILPQARHSVMVQDCHAGLLLFHSDTAEDADTLFENSTFLYNAINVETMTTRTVASVHPPRVSDHVSGFLLYTSGSTGKPKGILLSQENFRNHIAIKTHELDIGREIVLQQSSLGFDMAIVQTLCALANGGTVVVAPAHIRGDPVELSKLMLAHSVSFIIATPSEYLMMLHYGREFWEQCVCLRHICMGGEPVQQELLRELQALPQASTLQVTNCYGPTEITAAATFSSVSLASIEMDSTRGQSLVGKVLPNYSVYIMDQTGVALPTGMTGEICIGGGGVALGYSGEAESHQTQFLPDPYASEHDRAQGWTLMYRTGDKGWLSDEGNLYLVGRIDGDNQVKLHGQRIELDEVATQLRRQAEGKFAEIIVSVRGDPAFLVAHVVFASGMSMTSMDLAELARNLPLPRYMIPAAIIPVNHLPMTVNGKVDRKAIERLPLPNVDEGKLETEEEEEEEEEEEEEEEEEEEEKEEEARRPLTPLEASLRLIWHEALPQGCPNDAHADFFMHGGNSILLAKLQARIKQSTHIHVPIVDLYSSSTLCSMATRIGAGKQEDLSQSPAIDWVSETATPPGLLALNNGHGIDRMRNEAGQGSLRVLLTGATSFVGKALLKALLAHPRVTMVHCIAVPKEEEEEEEEEQKKLILLSSTIKIYTGSLLQPNLGLSQTEYTHLQENINIIIHAGAMGHCLNNYSSLRIPNLASTRFLATLAVSASASANSHRQIPFHYISSNRVTLLSGSTTSPPVSLAGQFPPTAAAAEGGFTASKWASERLLENFSHDIGLSVVIHRACAPVGKEAPSEDALNALLKFSRMMRAVPRWENFEGYFDFKDVHDIAEDIVFAVMRDGEGGGGEGEEEKETGKKQESSYPRLLPLLRFVHHSSGIRIPISDLPGHLQQQEEHLQQQQQQLQQQQQQQKNQNQNHILTSPPYEQLPVEEWIERALKAGIDPRIASYLDAVVRRREVVRFPFLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1QN30</accession>
    <name>N1QN30_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_153698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765978.1">
        <property type="nucleotide sequence ID" value="XM_016907520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QN30"/>
    <dbReference type="STRING" id="692275.N1QN30"/>
    <dbReference type="GeneID" id="27904657"/>
    <dbReference type="eggNOG" id="KOG3085">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_1_1_1"/>
    <dbReference type="OMA" id="TAPNGFW"/>
    <dbReference type="OrthoDB" id="1694274at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052898">
        <property type="entry name" value="ACAD10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829:SF1">
        <property type="entry name" value="HAD FAMILY PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF17857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="320" mass="35524" checksum="934BDAC49B694BC5" modified="2013-06-26" version="1">MATTTTTAAAAGGYPRVLLFDIGGVCVISPFQAILDYEKSHNIPLGYINHAISASGPTGAWAQIETGAIPLDEEFFRLFKADLEHEARWKAYYLKSTTTATSTTTTPGGRVDQNAEVSPPPPVPNIDAKWLFGEMMRIARTPDPHMWPALQKLRKAADASNGELVLAALSNTVIFPRGHEFNDDDEEEEEEHPDQQKDQKKKKKSSDSKTNEIRTLKTQIFDLFLSSAHIGLRKPDERIYQYAATRLQEYIRLQGKKGVRMQDVTFLDDIGTNLRTARKLGMNTIKVTLGRADLAVRELEILTGLELGGKGEEGRGKARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2023-02-22" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>N1QN31</accession>
    <name>N1QN31_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_77818</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765614.1">
        <property type="nucleotide sequence ID" value="XM_016910174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QN31"/>
    <dbReference type="GeneID" id="27907311"/>
    <dbReference type="HOGENOM" id="CLU_1235711_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF17493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="224" mass="22968" checksum="1472A95FED436A95" modified="2013-06-26" version="1">MGTCPGVSAGALSGAFIGVDAAFSAILRRDVGLCVVAGRFAGDFRVGVRNRVIGIAVCASYTERDGIPGKRSGSARCGVAISGISSSSSPWVDFLLCEAGRVTEGFLDGVCTADEFLAVGLLSSSSYDSAGGIPGNRSFVADLTAAGVRAAGVRGLDNDRDRLRELRSVLLLETRLAPFAGEAVLSNQASAAGCVFSGILSPSAVLGLELSDTDLRREDMVDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNB3</accession>
    <name>N1QNB3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Meiotic expression up-regulated protein 6 PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_146234</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765265.1">
        <property type="nucleotide sequence ID" value="XM_016903532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNB3"/>
    <dbReference type="STRING" id="692275.N1QNB3"/>
    <dbReference type="GeneID" id="27900669"/>
    <dbReference type="eggNOG" id="ENOG502S2JB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014855_0_0_1"/>
    <dbReference type="OMA" id="WAAHTGK"/>
    <dbReference type="OrthoDB" id="5593352at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039712">
        <property type="entry name" value="Meu6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039483">
        <property type="entry name" value="Meu6_PH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42073">
        <property type="entry name" value="MEIOTIC EXPRESSION UP-REGULATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42073:SF1">
        <property type="entry name" value="MEIOTIC EXPRESSION UP-REGULATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15406">
        <property type="entry name" value="PH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Meiotic expression up-regulated protein 6 PH" evidence="2">
        <location>
            <begin position="90"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="327"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="561"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="596"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF17144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="609" mass="64618" checksum="9E643B0DA063C0FC" modified="2013-06-26" version="1">MSDVQHNTTQAAETVVTDPATATSITKDAPLPTDAQVDSEVPKTETEAPAVTDGAATEPATETAEKAVEPITEGQLAYKGPGLLKSLIPSKKELWLSDEAVAPQSLDLYLRGEKPEISHAVVAWASQTGKGLLFFNKKGETNRAHPADVLALYDASDLKKLAAHEFSFNLDGHNHTFKAATEAERDGWYLSVERAIEHGKASKEEILASEGYKAEIEKLSKPNVVGAATTRSLSKPKKSTKVPNAERLGSSDGELEEGQKKTQKSRSTSRGILNRFKTNKEETEQKTAEKKAENEETKVEKEETKAPEETPVLASTEAAPVIASTSAADVPAAADVVAEDKPAETLPEEKAKANKRGSIFGRVSSGWSGLRSPAKEKDLKDAELKPDNVNAVSSEPPVLPETAATTEPAAVTAVPALEEPAVEPKAEEQKEEVSTPSKEKNNFLSGIGGFIKRNRSVSPNTNMKEPVKTEEVPAVPASEQAATTEPVAKVEEPVADVPAVAAEKPTEAAAEEPRTETTTPNKRQSVLGSLGRRASKALNRMQAPKKENAAPVATDAKAEEATASQTAEETPLANGEAKKEEPQTIGDVVPEAVNVGQAQHSTPTVTASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNM9</accession>
    <name>N1QNM9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">LigB-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_146808</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016766019.1">
        <property type="nucleotide sequence ID" value="XM_016903879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNM9"/>
    <dbReference type="GeneID" id="27901016"/>
    <dbReference type="eggNOG" id="ENOG502QS66">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046582_1_0_1"/>
    <dbReference type="OMA" id="EWGFDHG"/>
    <dbReference type="OrthoDB" id="7396853at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07363">
        <property type="entry name" value="45_DOPA_Dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014436">
        <property type="entry name" value="Extradiol_dOase_DODA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096:SF0">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53213">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110014" evidence="6">
        <location>
            <begin position="28"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Extradiol ring-cleavage dioxygenase class III enzyme subunit B" evidence="7">
        <location>
            <begin position="91"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF17898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="358" mass="40014" checksum="3944E0672310CDBA" modified="2013-06-26" version="1">MYPSSSSWFRILLIGLLIAATIPLLASQSTTLAQLLNRTKRSLILPFWTGRNNHNSSFTSNNTNTITRNFLSLNNNNINTTTIMPGQRTPVYFLSHGGPNIMEDTNHKAYAKLQEIGREITQQVQPKAVVVFSAHWEGYRDTIEVNTAENMGLIYDFYGFPAHYYDMKYPHTGSPQLAAHVIEKIRSAGIPVEGVRRGLDHGVWASFMCAFSPDKNPLNVPIVQVSISDNHDPDRHYQLGRAVASLRDEGVQIIVSGMAVHNLRDMARAWGRPGALDYVYSFDKALKEAVERKPEERQAAMAELLKRSDARKAHPTFEHLLPIYVGAGAASEESGKQLWTLPEGSMSWAQYRFGEVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNP7</accession>
    <name>N1QNP7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ran GTPase activating protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_33260</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765585.1">
        <property type="nucleotide sequence ID" value="XM_016908533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNP7"/>
    <dbReference type="STRING" id="692275.N1QNP7"/>
    <dbReference type="GeneID" id="27905670"/>
    <dbReference type="eggNOG" id="KOG1909">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028747_3_0_1"/>
    <dbReference type="OMA" id="NGSMEAW"/>
    <dbReference type="OrthoDB" id="184583at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006404">
        <property type="term" value="P:RNA import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00116">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="341"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="347"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF17464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="421" mass="45764" checksum="E7BFD794754B7AE9" modified="2013-06-26" version="1">MANVWSIRGQALKLNTAADIETHIGPLRDNADIEEVHLEGNTIGVEASAALAEVLATKKNLRSANLADIFTGRLLSEIPQALDALLTALLQCPNLHTINLNDNAFGLNTVEPLRPFLSKHTPLQHLYLNNNGLGPAAGTLVAEALAQLAENKAAARKEGKDVPHLETVVCGRNRLETGSMAAWVKAYTANNNVKTVKMVQNGIRQEGIAQLIQHGLSQCTALDTLDLQDNTFTALAAKTLSSVVPTWTEIRELAVGDCLLSGRGGRMLGDALAKAGNKKLEILRLQYNEIDTKGLKAISDAASAASALPRLRRVELNGNKFAEEDPSIESLRDVLAKRKEEKADEYHDVDEDDEDAWGLDELDELEDEDSDEEDDQDEDELDAEEEKVVKEADATEDEPVSQKQDADVDDLANALGKTEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M3AR92</accession>
    <name>M3AR92_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_152305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF07984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756105.1">
        <property type="nucleotide sequence ID" value="XM_016907364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AR92"/>
    <dbReference type="GeneID" id="27904501"/>
    <dbReference type="eggNOG" id="ENOG502RH61">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_575115_0_0_1"/>
    <dbReference type="OrthoDB" id="3638448at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028018">
        <property type="entry name" value="DUF4646"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15496">
        <property type="entry name" value="DUF4646"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF07984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="475" mass="52629" checksum="005D5426C0AAAC7D" modified="2013-05-01" version="1">MQSMRRSFSPDSFVRGPHPLAPRSLHVYTRGALLTSGFAYHPRLFDLNIHPIMWDKFTSQIVATARLSPAERARVWAVGTAAAMTTSFPESCHIGQNKSRRIQESKVREGLQNGSEDSLGDLLHQWNAGYFSERGLLARLDLNEAVQNSSPQQSKAMRRGSHWYAHKEDRELVRAERKFSIVITQIQHGEGLADSVQTSYSSGNTSPSSDQKSSIEVTGFKPLPELPTGAHPLIDVMNYWTNFDKPNQHPDALPTANQFAELEGDSHRILLNDQAIVPEDPFIGPLPLEEYSEFISQLYSQVAGQQSTVATQPASKLQPIEDESQMVAETHPLPLTQETMSEQEAMGNWPLPRDLPPNGNLLAQAEVAKACTAEPVAAHSEMTPKYRTAQPAQYRLYPNMSPTERSVRSFRTTGSTLEIAPSVQSTAIPRDIEEPRSKAMASPTASFFLPLDMKGVGTTLDFDPQLTIKDMATAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M3ASK7</accession>
    <name>M3ASK7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_152126</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756600.1">
        <property type="nucleotide sequence ID" value="XM_016907259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3ASK7"/>
    <dbReference type="STRING" id="692275.M3ASK7"/>
    <dbReference type="GeneID" id="27904396"/>
    <dbReference type="eggNOG" id="KOG1716">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023312_0_1_1"/>
    <dbReference type="OMA" id="FAWQGMQ"/>
    <dbReference type="OrthoDB" id="2017893at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14518">
        <property type="entry name" value="DSP_fungal_YVH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016278">
        <property type="entry name" value="DUSP12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848:SF4">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DUSP12"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="7">
        <location>
            <begin position="5"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="8">
        <location>
            <begin position="64"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="302"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="5">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR000941-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF08479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="327" mass="36656" checksum="AA2CE05EC3CC8ECF" modified="2013-05-01" version="1">MALLDKVPGELELYIGGLFTLRRKEALQTAGVTHVLSVLRLPLDDKLFENYEHKVVEVDDVDDENLLEHFDDCNKFIQTGLDAGGGVLVHCAMGKSRSATCVIAFLMHKYGLSPDEALAQLRESRPLCEPNDGFWKQLELYHEMGRPETVEDVPAYQRWLYLQEVALSRACGQAPDAEKIRFEDEHSTGSGNVDFEMRCKKCRRTLATSQYIVSHQAHRNDESGSPPNRTITSAPCAHYFLDPLSWMRSELEQGKLDGRLECPKCNTNVGKYAWQGMQCSCGNWVVPGISLAKGRIDEVKSKPHDNYGIRMPPSTSTRKPGQGQGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M3ASP6</accession>
    <name>M3ASP6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_152163</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016907281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3ASP6"/>
    <dbReference type="GeneID" id="27904418"/>
    <dbReference type="HOGENOM" id="CLU_877626_0_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="92"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="221"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF08524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="317" mass="35918" checksum="37A83BC4FB803D1D" modified="2013-05-01" version="1">MKAVAGNRIRGTRPSKHVGADKENILHKKTTAPLKHKKPREINGGIFGYAQCMGEKRKNADEARSILSPKFAGIGRPPVGKTGFFTRLHEEARARDSAEKEASSPDMDKVSRHARRHEQKQKALSFGIAGIIKPYIEGITNSWTTKLKDQHRQREAVRLDIDYKTGKPLNKPGFASTEDFARLAKRIEDLDQPFPDSRVSLHFRNPGGDVSINHVRVGDLKDNIFKQRKAQEAKHQQLKQDLDAIGEEIAGLRQEINDDASDRKKAAKEFEKQMKTFEKEKKEIEALAETERAEFRDEQKRATAVLNQKIHELFAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M3AT02</accession>
    <name>M3AT02_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">L domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_94473</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016910638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AT02"/>
    <dbReference type="STRING" id="692275.M3AT02"/>
    <dbReference type="GeneID" id="27907775"/>
    <dbReference type="eggNOG" id="ENOG502RW0K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_23_1_1"/>
    <dbReference type="OMA" id="SNWCGPD"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051582">
        <property type="entry name" value="LRR_extensin-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32093">
        <property type="entry name" value="LEUCINE-RICH REPEAT EXTENSIN-LIKE PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32093:SF128">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING N-TERMINAL PLANT-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF08644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="246" mass="26431" checksum="A537CCCF161D9701" modified="2013-05-01" version="1">MAFAATITVDDTGLKANWTGDDVCTFNATKCDMVPAGYKALVGLDFNQYGLGEGLQLTGFLDALTDLQFFHANGNDFEGMIPDLSNLQNISEIDLSVNGLSGPFPTEVLDLPLIFLDIRFNEFEGELPAKAFATPTLQALYINNNKFTGPLPEAVATDIFSFSMSANQFTGPIPESLANWADLEEAYMQENQLTGIIPESLCGLTNMSYINVAFNPDMKGTLGPICTSLLKNDGLNITGTGLKAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M3ATL4</accession>
    <name>M3ATL4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hpc2-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_151765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756975.1">
        <property type="nucleotide sequence ID" value="XM_016907031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3ATL4"/>
    <dbReference type="STRING" id="692275.M3ATL4"/>
    <dbReference type="GeneID" id="27904168"/>
    <dbReference type="eggNOG" id="ENOG502RG9A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012566_0_0_1"/>
    <dbReference type="OMA" id="MDGDVPM"/>
    <dbReference type="OrthoDB" id="5576775at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014840">
        <property type="entry name" value="HRD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08729">
        <property type="entry name" value="HUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hpc2-related" evidence="2">
        <location>
            <begin position="478"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="527"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="556"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="625"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF08854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="663" mass="69202" checksum="DD8003C6D1358520" modified="2013-05-01" version="1">MNMPSTLDDDAASDSSSLSSVQSPQNVALDDIRVASRSSFPAASTFAEGVVAHSAVPAPAHTISSTTPTTTTTTTSAAATPAHVPIKPKRVRKPKEPKVDGKDDKPKEKKARKPRVKHEEGAAVPPKKRQKKELVATPSDSPAGPRQSTLTEMAHNHFHPPAPPATAPPPQHMLASQSLQRQQPDIFIRDPLPTLSKPPTPTPRPISSGQNFDPIRGSIMDSAPQPSSLTANGIPSAQASPHINRASASPSINSLIDPPSKPVSYATRTPMHAQQPPGFVGSAQHSPTPPRAAPVSLSQQSASQPAAPAAPQPQPILSVDGSSMDIDTPRCVVQPSKSSSSAPTPQIQPKEKKAASPKAAGTGLLASNNLFGGPGAKQENDSRGPNIDIQIPLNRIGGNTINIAQEIFRKYGQDAINPRAAAHRAKLLQVAAAQNKLDGGSADDKSVDLMSDIDGDSNVEMGGMDDEGKSANGVDSTKPRKRRKKVEEYDKEDDFIDDTELAWEEKAAVAKDGFFVYSGLLVAEGTTANVESAAPSGRGRGGGRGGRGRGRGVPPAASTTTTQAAEKAKDPSAPARGRGSRGGKVPGAPRKPRITKAEKEKIEAEKAERERMIGNNHPPGGMPMQMSTTGSSTPASLAQTSQQPSLAPQMFANGTTTPQGVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M3ATR3</accession>
    <name>M3ATR3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase family 16 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_53027</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757015.1">
        <property type="nucleotide sequence ID" value="XM_016909252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3ATR3"/>
    <dbReference type="STRING" id="692275.M3ATR3"/>
    <dbReference type="GeneID" id="27906389"/>
    <dbReference type="eggNOG" id="ENOG502QUM3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016972_1_1_1"/>
    <dbReference type="OMA" id="VYVHDWQ"/>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004030918" evidence="1">
        <location>
            <begin position="20"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="23"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF08894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="355" mass="37810" checksum="EC172AF674D2C9C2" modified="2013-05-01" version="1">MSNLFPIILALAATASAAAILPRGYSNSTTNTTVGHAYSLVAEYSGTNFFDHFTAFSGSDPTEGHVQYQTLEAAAEQGLIGYVFNSTSNTNNAYIGVDSQNVAPNGRNAVRLTSKDTFNASSMAVIDVIHAPSQYGAWPAIWLLGSQGTWPASGESDILEFVHQTNYNAMTLHTSPDCVVDNVTTSAQQGQLLNSNCNAGNAGTGCSKKSTTAQTFSTAGSAFNSQTGGVYVHDWQPDGITVWMFPREHLPADLVAGSPNPSSWTQTPLARFTGAGCKFDRALQEMQLIINITFCGTWAGKVWESSGAKKATGVETCEQYVANHPEKFADTHWELGSVKFFSSTGEKPGVGPLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M3ATU3</accession>
    <name>M3ATU3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">2-ketogluconate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_151810</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757030.1">
        <property type="nucleotide sequence ID" value="XM_016907060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3ATU3"/>
    <dbReference type="GeneID" id="27904197"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_5_1"/>
    <dbReference type="OMA" id="SFIGTIC"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033229">
        <property type="term" value="F:cysteine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF63">
        <property type="entry name" value="HIGH AFFINITY CYSTEINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="312"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="440"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="469"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="83"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF08909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="535" mass="59874" checksum="89E4ACB3A11EAAD8" modified="2013-05-01" version="1">MGSSSNEQVTAAAAVVSPGITEKKKVDWDASEVERVHSQDDMQKDHQDYSRMDNEVAKYASATAIAISPAENRRLKMLIDKRVLTIMVLTYFLQALDKGTLSFTSIMGLREDLHLHGQQFSWLTTCIYIAILIVEYPINWLVQRLPIAKFLGTCIILWGSILACHAAAVNFAGITALRTLLGIFEAVCQPTFLIMSSMWYKREEQAFIVSCWYCMNGAQQIVGGLLAYCFSLIGNDRSLKSWQAIFVTYGILSVFWGLFVLWWLPDSPMRAKCFSEEDKQLMVERVRSNQTGLQNKVFRKEHLWEALTDVQCWCYCLIQVCTTLPTGGLGAFANIIIKGLGFTTLQVQLLAMVLGAYIIIVLFSSAWLVKRTGQNILVMALFCIPSFAGTIVLMTVENTNTATEAGLLFSYYIVLSFWAAQGLGMSLLSRNVAGQTKKSVAVTMNFVAWAAGNAIGPQVFLSWDSPRYFIAFATHLGCYTLLILTLIVLRITLMRRNAKRDQIASAGVSEAKDENTMHAFEDLTDKENAAFRYQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M3AUC9</accession>
    <name>M3AUC9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Autophagy-related protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SEPMUDRAFT_73576</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF09094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757215.1">
        <property type="nucleotide sequence ID" value="XM_016910032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AUC9"/>
    <dbReference type="STRING" id="692275.M3AUC9"/>
    <dbReference type="GeneID" id="27907169"/>
    <dbReference type="eggNOG" id="KOG0032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017167_2_0_1"/>
    <dbReference type="OMA" id="RRANDIC"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF22">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FHA" evidence="14">
        <location>
            <begin position="88"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="231"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="524"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMF09094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="544" mass="60448" checksum="C0953469AEC6D7B3" modified="2013-05-01" version="1">MEDVIACLYPHEDATDQNYAKVAVDKVENRSRRVAAQAPAALLDLPGRTTRESTVSFYDESEESDSEPPNIEGLQLTFTLGPKAAPGFWLGTAEGCDIVLPSSLPSISRHHCFLSFDEEGRLIVRDHSKHGTIVEYDGKGKERRRNFTWIIGGHIGPDNTKKIVIELNTKLRFRILVSKPSFPTTYSDNVKMFRANFAAETSLPLGALGIQSNASTAASSGTSSPTGDHIFLGEKKLGSGSFATVFRVWDVSTGAEFASKRFNDDQTSEWQREKSVMELISHKHIVPLHCALQKPILQLVLEYQPLGALSEQLHISRNEVIIILQQGLSALTYLHGRTPPIAHRDIKPANILVYTRNPLLIKLGDFGLSKANQNFKTHCGTHRYMAPEIFTSETRQLRQYSCAVDIWSFGLVILEYAYGSPPRCRELSWLGRIVKHLNECHESEPDGLTDLLLDMLVIDPKERISAAECLARALRLPVDVDLPSTPRPVQPYAAIAQSIEETSTLKPNQRSMVSVFANQAPQATRGPVGISQRERAMTPRPFTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M3AX13</accession>
    <name>M3AX13_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein YOP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_150245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759391.1">
        <property type="nucleotide sequence ID" value="XM_016906044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AX13"/>
    <dbReference type="STRING" id="692275.M3AX13"/>
    <dbReference type="GeneID" id="27903181"/>
    <dbReference type="eggNOG" id="KOG1726">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048918_1_0_1"/>
    <dbReference type="OMA" id="WMPWGWG"/>
    <dbReference type="OrthoDB" id="434647at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300">
        <property type="entry name" value="HVA22-LIKE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300:SF177">
        <property type="entry name" value="PROTEIN YOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="149"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="203"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="206"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="235"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="256"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF11270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="304" mass="34365" checksum="79199B4185518AB9" modified="2013-05-01" version="1">MYWTTLSIFLLLENQFDFILSWVPFYSWLRLAVHLYLVSPGQQGCVFLYQTYIHPFLEEHERQIDHMISDGHEKARTAGLDVVKMVIEYVRTQLLGQEPRRPTPPPSRNVSYTNQLFNRFTMPAARDALPATGTSDIFGMIGNLLQQTTSADSSSQDAQARDLSASGTLIPPHLTGSERDAYVRAQREKLSTLLRAFDAEAESTPGAWQSSSQPRSGTPRNPAARKPYLAPNEQDQMHRSRSESEFEDLGYETMPDPEHFRPRTDGAGDRTPLEPPAKGSAGWSNWIWGNYGDRDSLAEDKKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M3B667</accession>
    <name>M3B667_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_123630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763423.1">
        <property type="nucleotide sequence ID" value="XM_016901854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B667"/>
    <dbReference type="GeneID" id="27898991"/>
    <dbReference type="HOGENOM" id="CLU_2777543_0_0_1"/>
    <dbReference type="OrthoDB" id="2190219at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF15302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="69" mass="8196" checksum="E6C2D6AA9B292A4A" modified="2013-05-01" version="1">MNPQWLLGQRKSLMLSFQTTRSVHGDTRHMIYFFITREEPLKLYSGEFDAQRAEILSRSMAKERRLCMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M3B697</accession>
    <name>M3B697_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_114434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763448.1">
        <property type="nucleotide sequence ID" value="XM_016901092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B697"/>
    <dbReference type="STRING" id="692275.M3B697"/>
    <dbReference type="GeneID" id="27898229"/>
    <dbReference type="eggNOG" id="ENOG502SIJ0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034964_0_0_1"/>
    <dbReference type="OMA" id="FGMMNVE"/>
    <dbReference type="OrthoDB" id="5279008at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="11"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF15327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="500" mass="56642" checksum="788116A8103D1ECE" modified="2013-05-01" version="1">MASITPLPPSHWQLANLPPEILVRVASFLTTPELGALRRSCKEIEMKLFVDFAREFFTKRQFLIEHESLEALVGISRHPGLASRLREVLIDSSHFSLTPEIRCSRTKNGYVNRDVLLQTGLARDMLAEVFSNLPNLKTVGLRDYDGYGRIRDGPYAKWRSWGWSLFSENYVVDRRPHALLFPMLLSALTQANARPSNIEVFTKKSSKLQPESFLLPRNTSISAVLADLKTLMLDIPTDEISDTDDNPSFACVDVEDTPLRLFLHRTTQLQSLRLNFLPYINHADHPRRPRTRHQRGWRIVDWLGRPISVAAKSAPLTDSPTPPVHLPFLTSLELGKTMVTTADLVRTLAKFDLQSFSLHRICLDNPRPDSIAQDCWAQFLSQLSTSLSPSCRIRKIMIRQPSQGPYRWRVRGIHNGTSVVRFVPEGTNAANKAKAEKLCEIAFDSLYTGRTIHEWLRDMSGLTYIQWPLGHPVRVRLGLDMTTPEDAEEDEDGGGNDSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M3B7V2</accession>
    <name>M3B7V2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="7">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_36988</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="7">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="7"/>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764028.1">
        <property type="nucleotide sequence ID" value="XM_016908654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B7V2"/>
    <dbReference type="STRING" id="692275.M3B7V2"/>
    <dbReference type="GeneID" id="27905791"/>
    <dbReference type="eggNOG" id="KOG0350">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_15_2_1"/>
    <dbReference type="OMA" id="GHVIMYH"/>
    <dbReference type="OrthoDB" id="3370at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="29"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="441"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="301"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="365"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="365"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="377"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="401"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="421"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF15907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="613" mass="67727" checksum="24A8F478C8BC53EB" modified="2013-05-01" version="1" fragment="single">LNLHGALPIQQALVPLLLPPGIPGAKSLPGSEKVLPDVVVSAPTGSGKTVSYLLPIVEALRHSSANLVNLGRLSAVIIVPTQELVTQVAAVAESLSKGSKIKVGQSNSKHSLREEQKKLVHRGQRYDPAEYKRYMDQADIALDRNRPIDVRLTEYAAWLEASQPDPKTAQSIETMLDSSWIDNFIPTYESLIDIFVSTPQRLHDHIENTQGFTLENIEWLVLDEADRMLDNQHRSFLDLLNQETYRELHVYRDYSGSQPLQHQPPRLRKVVLSATMPGDVKVENAFRLRFPKLVVERGAEASEQAESGAQAYARRANATVEGHDSSEDMELPAFLREYCVPTGDGSEKPLVAIELIRSRILCQTEAKSAETSPTKPSRSSSVESSSSSDSGSEVSSISSSDSDDSSDESDEASSDMDIDSPQATSVRPRSTSHAADSLSKPLTHDEKSVAPTILLFTSSTETAHRLTHLIKTLVPDWKPYLHTILKNTPKSPQSNPSQPLIVISTDRAGRGLDGFAGRMFTHVVQYDVPRSLTDYVHRVGRTARAGRAGEAWTLYTHRQAGWFKEEVVRSERIGRKMAVEETKVGRASEELSLKYRQALEGMKEEVAGGKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M3BNW6</accession>
    <name>M3BNW6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_19788</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456324">
        <property type="protein sequence ID" value="EMF07873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016755994.1">
        <property type="nucleotide sequence ID" value="XM_016908319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BNW6"/>
    <dbReference type="GeneID" id="27905456"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2238415_0_0_1"/>
    <dbReference type="OrthoDB" id="3937064at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF07873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="86" mass="9920" checksum="38F95788DD32F772" modified="2013-05-01" version="1" fragment="single">LKDPHQVTSSLSPPANWREMERHVHHQQFRQAAFDEAGKLMGKRTFRILRYKARLCVRGDLQLPSTHETYAATLGYKVFRAITALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M3BPS4</accession>
    <name>M3BPS4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hemerythrin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_121662</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF08173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756294.1">
        <property type="nucleotide sequence ID" value="XM_016901702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BPS4"/>
    <dbReference type="STRING" id="692275.M3BPS4"/>
    <dbReference type="GeneID" id="27898839"/>
    <dbReference type="eggNOG" id="ENOG502S054">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079417_0_0_1"/>
    <dbReference type="OMA" id="HTHIEHE"/>
    <dbReference type="OrthoDB" id="9983919at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.520">
        <property type="entry name" value="nmb1532 protein domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35585">
        <property type="entry name" value="HHE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35585:SF1">
        <property type="entry name" value="HHE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin-like" evidence="2">
        <location>
            <begin position="10"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF08173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="216" mass="25195" checksum="16E00D03978C8E44" modified="2013-05-01" version="1">MEQHIGSKTISEAVGSDHEYMDLVIQTLKSATSHEERIQWRNQLTWTFARHAISEELTWYPAMEKLFGEKGIAMAELDRQQHQAIKEDLYQIQSMNPDDARFFPLVEKLEQDFKVHVKHEKEEDMPMLEERLTRKESNEMAKWWQRTKGITPTRSHPSAPNRPYAENLVGLLAMPIDKVGDWVRSFPEDDRMEEVTRTGRAMKKKKTSTTDGGSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M3BW70</accession>
    <name>M3BW70_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_127074</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759685.1">
        <property type="nucleotide sequence ID" value="XM_016902119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BW70"/>
    <dbReference type="STRING" id="692275.M3BW70"/>
    <dbReference type="GeneID" id="27899256"/>
    <dbReference type="eggNOG" id="KOG0032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054430_0_0_1"/>
    <dbReference type="OMA" id="WVQVFEV"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010389">
        <property type="term" value="P:regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF472">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 4, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF11564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="319" mass="35964" checksum="5EF149C6130479BC" modified="2013-05-01" version="1">MARSVVGKSGRIYTLQETIQDMGRPLSCVFRASDGTNEFILKEVPQDWNARLQIYNLIGSSPFVRNLVDTVPERKIFVFDHLQTNLLQLAQKDLPQSTMKHILKCTLSGIAAMHEKDIIHNDIKANNIMVQMTPPESEWKIAKVQVVDLEDSAHLRGPESAVIGAQVGNIMWRSPEAHAMGPIRKPSDIFSFGLVCIYAMTQILPFAVDESELPEGIDPLAVVLELQISYFAEVDDLNAFLRYLGDKPEWVEIFQAVASAFAGDQPRRPFRLWEGIDVDQADSFRSLILGLTNFDPAKRLTAQQALEHEWFKDDMIPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M3BWK7</accession>
    <name>M3BWK7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_149097</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760532.1">
        <property type="nucleotide sequence ID" value="XM_016905338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BWK7"/>
    <dbReference type="STRING" id="692275.M3BWK7"/>
    <dbReference type="GeneID" id="27902475"/>
    <dbReference type="eggNOG" id="KOG1815">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009823_4_1_1"/>
    <dbReference type="OMA" id="HRFCMIC"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20346">
        <property type="entry name" value="BRcat_RBR_ANKIB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20356">
        <property type="entry name" value="Rcat_RBR_HHARI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16625">
        <property type="entry name" value="RING-HC_RBR_HEL2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1750:FF:000007">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000019">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045840">
        <property type="entry name" value="Ariadne"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048962">
        <property type="entry name" value="ARIH1-like_UBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19422">
        <property type="entry name" value="Ariadne"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21235">
        <property type="entry name" value="UBA_ARI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="144"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="148"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF12411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="522" mass="60606" checksum="693B44F3E88FE3A2" modified="2013-05-01" version="1">MESDDEVQSMASSADMGMMEDEDSSVDFGANDSDGDMDDFNDEDDGGDMFQSQDKLMKPQKKAFEVDFKSYSPDDIQAQQEQQITEVSTLLEQPREATAILLRYGRWNKERVIEQYMDDQEAILEKAGLGQDLQRTPPRIETIDGFACEICCEDEPGLQSFAMKCGHRYCVDCYRQYLGQKIRDEGEAARIKCPGDGCNNVVDTKSLELLVPSELKDRYHELLMRTYVDDKENLKWCPAPECIYAIECSVKKRDLNRIVPTVTCEGKHNFCFGCTLADHQPCPCKLVKQWLKKCEDDSETANWINANTKECPKCNSTIEKNGGCNHMTCRKCRNEFCWMCMGVWSEHGTSWYNCNRFEEKSGSDARDAQARSRQSLERYLHYYNRYANHEQSAKLDKNIYEKTEKKMQLLQNQSGLSWIEVQFLENASHALQLCRQTLKWTYAFAYYLERNNQTEIFEDNQKDLEMAVENLSEMFEKPTEQLSELKVDMMDKTSYCNQRRIVLLDDTAKNLKDVNWKFTIDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>M3BWL2</accession>
    <name>M3BWL2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_117008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760537.1">
        <property type="nucleotide sequence ID" value="XM_016901301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BWL2"/>
    <dbReference type="GeneID" id="27898438"/>
    <dbReference type="HOGENOM" id="CLU_2851183_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF12416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="65" mass="6792" checksum="92E96B2D295CC1F4" modified="2013-05-01" version="1">MRVRRMTVIAFSSPGGNASINDSADMPDAAQSDTPTRPSLNHTGKESGLVKLTACRILPGSHPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M3C0G2</accession>
    <name>M3C0G2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial</fullName>
            <ecNumber evidence="11">1.14.15.45</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">2-methoxy-6-polyprenolphenol 4-hydroxylase</fullName>
            <ecNumber evidence="11">1.14.15.46</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">COQ6</name>
        <name evidence="13" type="ORF">SEPMUDRAFT_125497</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">FAD-dependent monooxygenase required for two non-consecutive steps during ubiquinone biosynthesis. Required for the C5-ring hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 4-hydroxy-3-(all-trans-polyprenyl)benzoic acid to 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid. Also acts downstream of coq4, for the C1-hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 2-methoxy-6-(all-trans-polyprenyl)phenol to 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol. The electrons required for the hydroxylation reaction are funneled indirectly to coq6 from NADPH via a ferredoxin/ferredoxin reductase system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 2-methoxy-6-(all-trans-polyprenyl)phenol + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = a 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:81183"/>
            <dbReference type="Rhea" id="RHEA-COMP:9551"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10858"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:62731"/>
            <dbReference type="ChEBI" id="CHEBI:84166"/>
            <dbReference type="EC" id="1.14.15.46"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 4-hydroxy-3-(all-trans-polyprenyl)benzoate + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = a 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:81195"/>
            <dbReference type="Rhea" id="RHEA-COMP:9514"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10930"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:64694"/>
            <dbReference type="ChEBI" id="CHEBI:78396"/>
            <dbReference type="EC" id="1.14.15.45"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the UbiH/COQ6 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.45" evidence="11"/>
    <dbReference type="EC" id="1.14.15.46" evidence="11"/>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761937.1">
        <property type="nucleotide sequence ID" value="XM_016901991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C0G2"/>
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        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="entry name" value="Ubiquinone biosynthesis monooxygenase COQ6"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UBIH"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0274">FAD</keyword>
    <keyword evidence="3 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 11" id="KW-0831">Ubiquinone biosynthesis</keyword>
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        <location>
            <begin position="38"/>
            <end position="466"/>
        </location>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF13816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="511" mass="54615" checksum="751E2E1D817ACCEA" modified="2013-05-01" version="1">MAGLSSRHGLTKLLALPPSLRRSLYSTAATLSSTPELYDVVCIGGGPAGLSLISALRSNASTKNLKIALIDGQELKASSSNDPKAFSNRCSSLTPSSVRFLDQNGAWSYINAARTQPYHGMDVWDGVSGSKIHFDPLDTAGGGILDTIAAAIPGSSLQQSRRRYEQEDVNTVATMCENSNLTSALLRRLQDADAVDAMDQTRVESITYGPEAKDDDSLDLSLWPIVNLPGDRSLAARLLIGADGANSPVRAFANIPSHGWDYGQHGVVATLDLDRPFSQADLRTAYQRFLPTGPIALLPLPGNKASLVWSITAPLAAKLKQLSSHNFTTMVNAAFRLMMVDIEYLMHNPRSDLADELSWREPHTDPRATGLPSTLPRVVGVQEGTIASFPLRMRHADTYTGHRVALIGDAAHTVHPLAGQGLNLGLADAEALANCIAHGVNHGMDIGSCWALDEYNSQRWAANNAMLGVVDKLQKLYSASSGPVVWGRSLGLDLVNRLGPLKGALMGAAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M3C111</accession>
    <name>M3C111_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_147849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EMF13976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016904550.1"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_493609_0_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="345"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF13976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="552" mass="61014" checksum="DE13D7ACEBF95FEE" modified="2013-05-01" version="1">MRSRQRIPRSSSVESLSDKFKSWNSSLSNLQLRASVALKPVQEGQEGLPTNNAFTKSTPTLIDCAQDSVIDLGEYRDGYTGGDLPLGERPEHSQRYGTGSRDRSRSRMRLSARGSTDSESSENEMLFLQRIEKTRNGHSAHAPAATLQPDRKRTMRHARSMSRMTMRTEKSLPPLPEVQAQSPVKKTFMESVRSTRYLRNMRSLPQIKPYVNPHESMDFKCVGSPSEAVSAVEHAFEEREMQSEKDELARSINLTRARMCDQRIEVLERSVLLDREASKAASEIDEFLSLPAGSTMTVDEVTGTAELVGPAGYSGLATGERWASLQYHGMGGGSDVDGSRKRFSRSASRPSSRQSNRPPSRQHESSQASHAKPVLKLNTKFASSPVGTLDNMFTAITGDRWRSIGMARTAVDRRWVVVLSGASSLISDNDDTRSIRSLLTPSSSVRTPWSRSKSRGMATRREPSTPASAFGMMMTPSYSDDDEEEEYGMPGTPSISVTPIFAPDGAGFLGARNMGERMPLARRNTRTGQRLETALSPSVREDDDCSPMTPML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M3C2V7</accession>
    <name>M3C2V7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Regulator of G protein signaling superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_148270</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016904818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C2V7"/>
    <dbReference type="STRING" id="692275.M3C2V7"/>
    <dbReference type="GeneID" id="27901955"/>
    <dbReference type="eggNOG" id="ENOG502QRI8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029881_1_1_1"/>
    <dbReference type="OMA" id="WAPIREP"/>
    <dbReference type="OrthoDB" id="5584247at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07440">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052246">
        <property type="entry name" value="Cell_Polariz_PKAAnc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13155:SF1">
        <property type="entry name" value="A-KINASE ANCHOR PROTEIN 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13155">
        <property type="entry name" value="A-KINASE ANCHOR PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="267"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="3">
        <location>
            <begin position="193"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF14606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="378" mass="42447" checksum="37D1041C58514723" modified="2013-05-01" version="1">MDGDDRAPTPDAAARERLPNLFEVLSRRTLAPVDLFSFYIYMRDVQRSVDYLDFWLDVSQHMSLCRHYVRELRRSVLVSTPELDKGSKRSSQILDSNGNNMERTSSAEQGPSGVYHDKSGDRQTPDQRLSAFLRNDNGTGHSPQDSAGSHPNSESALEQPRPSFMAGHDGSPSSGNNGSPQHTVARADIRASAEKILYTFLLPGAEREIILPQGILNEITHAIESEGRDDPEVFDAAKDYVFQAMERDAFPGFLRAKALGNIVQPSMMLRLICGLVALFGALWTAFVLIFLNKSRATRCWLILPFTVGIYLLATHQYMLDPIMALLGFSEYTFFSFARIKEPFVKKLLHQRALMCLLWISLIDVALLCLFIFVPGKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M3C4L3</accession>
    <name>M3C4L3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_147170</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763362.1">
        <property type="nucleotide sequence ID" value="XM_016904129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C4L3"/>
    <dbReference type="STRING" id="692275.M3C4L3"/>
    <dbReference type="GeneID" id="27901266"/>
    <dbReference type="eggNOG" id="KOG0241">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001485_2_3_1"/>
    <dbReference type="OMA" id="SFWSHNT"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01365">
        <property type="entry name" value="KISc_KIF1A_KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000050">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3 4" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="7">
        <location>
            <begin position="45"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="538"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="446"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="147"/>
            <end position="154"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF15241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="605" mass="68556" checksum="F69617AFC5D17853" modified="2013-05-01" version="1">MPRALTTPDLYHHSTASAPSLRSRTPIDIADMQRPFTPPDGDGGNVKVVVRVRKHIKREIEAGQPCLVSMNPETQETTIQPPDLTDEQLRHSRKQYEEKSFTFDKSFWSQNEADPHFASQSDIYNSFGEEFLDHNFDGYHTCIFAYGQTGSGKSYTMMGTPDQPGLIPRTCRGLFERVESEQSGSITYNVHVSYFEIYNEHVKDLLTPRTNPPTYLKIRESKGEGVFVQNLTDEKVESYEDIERIMRTGDLNRTVASTKMNDTSSRSHAVFTLTLKQIQADLSDDSTIERVARMRLVDLAGSERAGRTEATGQRLREGGNINQSLTTLGRVIAALADPKRQRATRMTGLQNQTKRRAEVVPYRDSVLTWLLRDSLGGNSKTAMVACISPTDYDETLSTLRYADQAKRIRTKAHVNQDNKSAAERDAQIMEMAETIKQLQLSVNTAATRKRDEADRARDELEDYQRQVGKMHRAMQESKAVSDTKIRALTQEVEELRPQNEALRMEIETLRRHLALAVGELKNPIVLPEAFMDNEHDENSVYEDSDHDSGVDDGLSYSEDQNEFEHESWQADVDALLNDLGLFKRKVMDDKSRFPHPDVGSQVSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M3C5F5</accession>
    <name>M3C5F5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_147366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763612.1">
        <property type="nucleotide sequence ID" value="XM_016904250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C5F5"/>
    <dbReference type="STRING" id="692275.M3C5F5"/>
    <dbReference type="GeneID" id="27901387"/>
    <dbReference type="eggNOG" id="ENOG502SA85">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_882815_0_0_1"/>
    <dbReference type="OMA" id="WMEIPLP"/>
    <dbReference type="OrthoDB" id="5371646at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF15491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="337" mass="35950" checksum="81489BC7E129BE2E" modified="2013-05-01" version="1">MATPPERPWTTHEKNSLMAEIIKTANPPVNVLFSVIQSLQLQPRWDDIPLPPGRSLNSCRLAYDDVRRSLSAPMGASLAPLNPTPMTAMTGSISTTLKRPFPYESAWLGSSTAGPTGGLTGREIRPKPSNPSAVPIQPSPTDQPTKKKRGRPTKAEALAKAEAAAASVPAFGEPGPVSMSRPASQSTPQPPPQPPPQPMTTMLSTARTDEPKPGLPPSLPPVTRMPIAAMLTPTAGEPHGGSLAHARPSSGRRRRARSTKSEQEEGESPPGRGNETGADYESPYARPDAPETPVKTAVLRNRGEEEEEQDIPRALPMPGLAHDTSDPRLSSDTEQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M3C6C4</accession>
    <name>M3C6C4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_147599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763937.1">
        <property type="nucleotide sequence ID" value="XM_016904406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C6C4"/>
    <dbReference type="GeneID" id="27901543"/>
    <dbReference type="eggNOG" id="ENOG502RM5G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_857951_0_0_1"/>
    <dbReference type="OMA" id="MMFHREH"/>
    <dbReference type="OrthoDB" id="3867271at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="354"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF15816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="363" mass="40426" checksum="6A21B117DA81BDAD" modified="2013-05-01" version="1">MACEVDHSPFADTTIDDDWMKAEDGNGSLNDISDFNSNFGHQSYDTINPSLTYSNHSTPATSDHHAYTFNATANSDLNQTLSPQPTYEAYPSSFNNAPETPYFSSVEMNHAAPNHHSLLRNQHFSHRRSVSEPPGMPEQSPITFHRKEHWIGAPVRSKPTALKSLPKHKANRSHPYPAPAPTRKPAKQQPYSHVQQRAMAQDARPDMQRSQTQPLHHYQQYAPTSAPMMSPQHFMSMSPDQLHAPPSSHMMMAANPFIPSTSRVCTPTPIDPSLREPPIPSKRVKRETTLNIMMTVDELRALVCEAVQKAVGGSGERMNGESTQREQERTEADSEERSVSPKAVPVEEVEEVDAGVGVMKDET</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M3C883</accession>
    <name>M3C883_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_23638</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF08105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756226.1">
        <property type="nucleotide sequence ID" value="XM_016908374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C883"/>
    <dbReference type="STRING" id="692275.M3C883"/>
    <dbReference type="GeneID" id="27905511"/>
    <dbReference type="eggNOG" id="KOG0143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1346091_0_0_1"/>
    <dbReference type="OMA" id="LHANPAM"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209:SF881">
        <property type="entry name" value="FI07970P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209">
        <property type="entry name" value="OXIDOREDUCTASE, 2OG-FE II OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-haem dioxygenase N-terminal" evidence="4">
        <location>
            <begin position="4"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF08105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="204" mass="22633" checksum="5850A7DE43BD9AE0" modified="2013-05-01" version="1" fragment="single">FTSIPTISLLPLFSPSSTSPSHLQSLAAEIHSACTTTGFFYATDHGIPLASQFEIFAVMEKFFRQVGEKEKMQEAHLHANPAMRGYEPLGETGRGRKGDLKEAFTIGDCVHDSEQVSFYQSLYPHSSPLPSIPRSQNIWPKPSSAPGFREGMYAYYREIFPVAMKLVEIFGVALGVDSHDDENKNGGGDGGLEKDFQWPIWGMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M3C9L5</accession>
    <name>M3C9L5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_74240</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL32 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756641.1">
        <property type="nucleotide sequence ID" value="XM_016910056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C9L5"/>
    <dbReference type="STRING" id="692275.M3C9L5"/>
    <dbReference type="GeneID" id="27907193"/>
    <dbReference type="eggNOG" id="KOG4080">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4155">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_11_1"/>
    <dbReference type="OMA" id="LDSSMCL"/>
    <dbReference type="OrthoDB" id="10251741at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002677">
        <property type="entry name" value="Ribosomal_bL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051510">
        <property type="entry name" value="SKI8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01031">
        <property type="entry name" value="rpmF_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44090:SF1">
        <property type="entry name" value="SUPERKILLER COMPLEX PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44090">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01783">
        <property type="entry name" value="Ribosomal_L32p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004031725" evidence="7">
        <location>
            <begin position="22"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="326"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="368"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF08520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="452" mass="49187" checksum="A0846C409A0E3505" modified="2013-05-01" version="1">MATIRAPSTTFLSAFLPVVRARLLPHQEQAVRRIPLLHQIQQLRAAASLLPAVLVPIPSLLEHIWDGILKAVPKKKTSHMKKRHRQMAGKALKDVTALNKCSACGRTKRAHVLCPYCQYLQTLTIPDAHPTDIFSLAVTPSHLLTASGSSSIKIYSTRGQTIHADSTEDENPYPLTQTLDKVHPLGCHHICASLDGKVAASVGFAGDLRVWHYNDESGQWQPKGSIVPSDKKTAAGEHWAPALNENGQYLAVTTSDGRVNVYDTSSLDTSDGSAAASVEKITTYATKGSFGMSIDISPNGEMTGTGHQSGSIYIFNNSTKRLAHSLSGLIKPVRSVKFSPANRYLAAAGDARIIALYDTQSGEQVANFTGHGSWIMTLDWNFSGEYLLSGSYDGKAKIWSIERRECVATQTESEKCLWAVKWLWHSPTARNEVFVGAGAGRSLSFYREASGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M3CB50</accession>
    <name>M3CB50_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase S54 rhomboid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_120949</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S54 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF09065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757186.1">
        <property type="nucleotide sequence ID" value="XM_016901648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CB50"/>
    <dbReference type="STRING" id="692275.M3CB50"/>
    <dbReference type="GeneID" id="27898785"/>
    <dbReference type="eggNOG" id="KOG2980">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055068_7_3_1"/>
    <dbReference type="OMA" id="AAFITHR"/>
    <dbReference type="OrthoDB" id="418595at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050925">
        <property type="entry name" value="Rhomboid_protease_S54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731:SF14">
        <property type="entry name" value="PRESENILIN-ASSOCIATED RHOMBOID-LIKE PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731">
        <property type="entry name" value="RHOMBOID PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="8">
        <location>
            <begin position="69"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF09065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="246" mass="27061" checksum="8C81D15BD10791C4" modified="2013-05-01" version="1">MSFRRAFNDSSLFNAQASYRSAKWAVGTLLFFNGGVFGAWTYARGSRDTELLRQLEEHATLSEHNLAAGRYYTYVTSAFSHKELPHFAFNMFALFTYGGLLASVPGIGALHIYGLAITSSIAASAAFITHRRRKTKQREKKRDLQSRFSGNAIIRETGLGASGIVMAAAAVATCLRPTIQVVIFPMPMPMPLYVATGLVAAVDAYMIDKGDKIGHDAHLGGFAWGAVYYLLLLRNKGGIWRLLSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>M3CBQ1</accession>
    <name>M3CBQ1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_119594</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF09852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757973.1">
        <property type="nucleotide sequence ID" value="XM_016901530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CBQ1"/>
    <dbReference type="GeneID" id="27898667"/>
    <dbReference type="HOGENOM" id="CLU_2211629_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF09852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="107" mass="12372" checksum="D19F319846C1D693" modified="2013-05-01" version="1">MKRNWWRSSGRTKLTSLMTLSIFIVLADPIAVLRLSLSFSYRHHQVVGEKVSSNEDVQEEGVQDVKWYWTKHTIIRATSNAVRNVMLRDLVRSLEIDGSICQSRVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M3CDR3</accession>
    <name>M3CDR3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_68476</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759272.1">
        <property type="nucleotide sequence ID" value="XM_016909824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CDR3"/>
    <dbReference type="STRING" id="692275.M3CDR3"/>
    <dbReference type="GeneID" id="27906961"/>
    <dbReference type="eggNOG" id="ENOG502S03U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014593_0_0_1"/>
    <dbReference type="OMA" id="PSAQWAH"/>
    <dbReference type="OrthoDB" id="4538483at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF11151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="524" mass="56656" checksum="3C946FC4BCDB0B50" modified="2013-05-01" version="1">MISYNRLIISILNKATLNAADAASVAGLLDTVLALVQLWLCTSDPGVATLAQQLLLDLLKIDQEIQPGPDSHLPSGGQGLMWKRLFGDQDVYRMFFEACSVISTASPSLSLSKGQKTLAQARLMEWLPKVAAMDWNAVARSYHPEIEAEFKSQGGLLGFATSYMVDTKDDVLMYRCLIDFYSEILDATGPRASHLETSEPSAGLAYLITKGVHTSTAAIYLQLPGTAIDPLEAMFLYGPAANYIATYASRYPSHFLASQLPQQVNQRLSTALDQSPAKWAHAESPKHDLHLLASLPRDALLTSSGGWQSSPLSLVPSKATNPDALNTLATIFHGPNRDIVFGSASNGSSTEPGLEKEAALARALYHHYLSHNPRFWQDIVSHADTVALKDLALSAINVLVSIITANWSESPHVEIPNTMVSAPSGHIALLSPPAVEYTMPYMLKPPRTFANLVGGRGDSESSAYKIAAAKFDALRALNSRLETQVRQTPGAGYEDILRTVSRKLADGPWGREGEVGGHIATLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M3CF62</accession>
    <name>M3CF62_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD repeat-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_163576</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat AIP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760544.1">
        <property type="nucleotide sequence ID" value="XM_016908070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CF62"/>
    <dbReference type="STRING" id="692275.M3CF62"/>
    <dbReference type="GeneID" id="27905207"/>
    <dbReference type="eggNOG" id="KOG0318">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015246_1_0_1"/>
    <dbReference type="OMA" id="FYQGPPF"/>
    <dbReference type="OrthoDB" id="2306at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003786">
        <property type="term" value="F:actin lateral binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051014">
        <property type="term" value="P:actin filament severing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032466">
        <property type="term" value="P:negative regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000102">
        <property type="entry name" value="Actin-interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000167">
        <property type="entry name" value="Actin-interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19856:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19856">
        <property type="entry name" value="WD-REPEATCONTAINING PROTEIN WDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23410">
        <property type="entry name" value="Beta-prop_VPS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="54"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="185"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="231"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="324"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="540"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="583"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF12423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="619" mass="65162" checksum="76C21A28C465BF3A" modified="2013-05-01" version="1">MSITPEAIWAASPSTTRGQPTPLSTDSKGERICYASNKSIFVRSIDHPEIAKQYTGHTTTTSVARFSPSGFYIASGDVSGSVRVWDSVGAETTKGEYHIIAGRINDIAWDGDSQRIIAVGDGKERFGHCITADSGNSVGEISGHSQQINCVDVRKQRPLRAATGSDDMSMCFFHGAPFKFNTSVRGKHDKFVYGTQFSPDGSSLVTVGSDRRIWIYDGKTGEAVKQIGEGEDAHKGSIFGVSWSPDGKKVVTASGDQTVKVWDVESGKLVQSWKMGPEGKSSVPDQQVGVVWPQGRSDGLIISVDLEGNLNYFKLGDDKPIRVVRGHQKAVTAATAPSDGQTLWTGGADGRLRAWDVSAGSAAMIDGEPHSNYVASVSAVPNADSKSARIFSVGWDDFLRTIDSSQKSFVGAVKTEGQPKAATVAVIGGSPHTLVATAAGIASYVDGESIGLQKTPAPPTALAASGSIIAAGSDDKVVRIFDASSPSSFSEIVTLKEATAPISALSFSGDGKYLAVGLSSGKIFAYSNASGAWTLETNRWSAHTARVTTLAWSPDNKKAVSGGLDTNVFVWSLTDPGKRIKAPNAHKEGVGAVAWTEDDRVISTGADAAVKVWKVAGVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M3CHU2</accession>
    <name>M3CHU2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_148684</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761474.1">
        <property type="nucleotide sequence ID" value="XM_016905080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CHU2"/>
    <dbReference type="STRING" id="692275.M3CHU2"/>
    <dbReference type="GeneID" id="27902217"/>
    <dbReference type="eggNOG" id="ENOG502S4MS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094640_0_0_1"/>
    <dbReference type="OMA" id="ASSRWQI"/>
    <dbReference type="OrthoDB" id="9975758at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF13353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="197" mass="21932" checksum="F6B2FE3BEAC61E59" modified="2013-05-01" version="1">MASITLRAPTFSPAKPPAGFQTPAIAWLTETWHVTHSTLPMWKSKKNVRIQYTPLEPSRPDIAKENTDRLDDLVTSQPLHGDKVSSIRGVDKASGSGESRGEWDWRGKGWLMIASSHWEVLGWGEEEHNNGNKWAVTAFAKTLFTPAGIDVYSQSRAGVLLETLEGIKSALAQVDDQDVQKMAKDIFEVMIDDTRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M3CIH2</accession>
    <name>M3CIH2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_148856</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761739.1">
        <property type="nucleotide sequence ID" value="XM_016905188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CIH2"/>
    <dbReference type="STRING" id="692275.M3CIH2"/>
    <dbReference type="GeneID" id="27902325"/>
    <dbReference type="eggNOG" id="KOG4144">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061829_0_0_1"/>
    <dbReference type="OMA" id="WLEHAAF"/>
    <dbReference type="OrthoDB" id="30840at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004059">
        <property type="term" value="F:aralkylamine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051635">
        <property type="entry name" value="SNAT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10908">
        <property type="entry name" value="SEROTONIN N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10908:SF0">
        <property type="entry name" value="SEROTONIN N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="62"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF13618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="264" mass="29236" checksum="0966A5976C93A322" modified="2013-05-01" version="1">MPRDLASLLSQATEDTLDNMPQLSSQNKEAGSSHLTADPDHDYDSDSTEYIDELGQSNAKRDPLHPYTQTLSLSDIESCIRLEDAAFPPHERCTREKFYYRLRHCGELSLGIFTSEENSEATTASTASPAYSGAPERKSVLLGHIVATMTTNATVTDDDMAIPTRENPDPKLGNKSQGRTVCIHSLAVLPEYQKRSLGSTLMKAYLHRLKTQSVADHVALIAHDYLIPYYEQFGFRSLGPSKAQFGGGGWYDMTIDINAIEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M3CJP9</accession>
    <name>M3CJP9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Peroxisomal ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_62039</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762169.1">
        <property type="nucleotide sequence ID" value="XM_016909584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CJP9"/>
    <dbReference type="STRING" id="692275.M3CJP9"/>
    <dbReference type="GeneID" id="27906721"/>
    <dbReference type="eggNOG" id="KOG0064">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007587_1_0_1"/>
    <dbReference type="OMA" id="IHDMYLD"/>
    <dbReference type="OrthoDB" id="422637at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF67">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY D MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="181"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="543"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="442"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF14048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="828" mass="92266" checksum="C03D9826F3DB0FF9" modified="2013-05-01" version="1">MANQSTLRQRPSDRLSQWFDHFYVRLAARIDQLQSRSPLDKTTTRLVATLALALAIVTSSYGGYRYYKGVEKEKEVGRRLLRRNSGLKAKDGTRTIYVPYKDTSSKVVIHPIKATTFDAHRRFFLNPIRQRSSGRQIALDAPPTNIKPGLNVAFVHQFMAIMQIAVPRLGSKESGLLATHAFFLLLRTYLSLVVATLDGEIVRDLIAGQGKAFLLGLGKWLSVGVVASYTNSMIKFLQSKISIAFRTRLTRYIHDLYLSSNMSYYKMHTLDGSIDQGADQFICQDLTLFCDNAAQLYSSLGKPLVDLFTFNYQLYKSLGPLALGGLLSNYAATAILLKRLSPPFGKLKAAEGRKEGAFRALHSRLIANAEEVAFYAGGPTEHALLDAGFKELRKMMETIYRVKIGYNMLEDFVLKYTWSALGFVITSLPVFLPGLHIAPEPPKKAGVTGGSPESTEDNKTGSRTKQFITNKRLMLNLADAGSRMMYAIKDLSELAGQTSRVFMLISTLHRVHANAYNQPRDRYPEPYNLADVHGTLHKGYDGVRLEDVPIVAPAPHPGGGEELIDNLSFVVGPGDHLLITGPNGAGKSAVARVVAGLWPTYRGLTSRPRTTGQDGIMFLPQKVYLSHGTLRDQVIYPHTEVEMKEAGRTEMELLGILEESKLGYIPDREGGWDTRKMWQDVLSGGEKQRMSIARLLYHEPRYAFIDEGTSAVSSDVEGILYETCKKKGITLITISTRASLKRYHSYTLTLGLGEEANEYEFNRIGTATEKSSVEREIQELREQLSQVEGWKLRRKAIDEELSKVWVSGQELPAPDYHNGSSEGETVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M3CL42</accession>
    <name>M3CL42_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_115775</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peroxiredoxin family. Prx6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762629.1">
        <property type="nucleotide sequence ID" value="XM_016901198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CL42"/>
    <dbReference type="STRING" id="692275.M3CL42"/>
    <dbReference type="GeneID" id="27898335"/>
    <dbReference type="eggNOG" id="KOG0854">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_4_2_1"/>
    <dbReference type="OMA" id="RLTMLYP"/>
    <dbReference type="OrthoDB" id="2991872at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03016">
        <property type="entry name" value="PRX_1cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1020.10:FF:000001">
        <property type="entry name" value="1-Cys peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000011">
        <property type="entry name" value="Peroxiredoxin PRX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1020.10">
        <property type="entry name" value="Antioxidant, Horf6, Chain A, domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045020">
        <property type="entry name" value="PRX_1cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009668">
        <property type="entry name" value="PRK13189.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503">
        <property type="entry name" value="MCG48959-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503:SF9">
        <property type="entry name" value="PEROXIREDOXIN PRX1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4 6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="44"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="7">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF14508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="254" mass="28282" checksum="2B0D8847DB9F49EE" modified="2013-05-01" version="1">MASILARGALRATRLSATHGSFASRQASPIFKRFLSTPAEQPRLRLGSVAPNFQAQTTHGDIDFHNFIEGKWTILFSHPADFTPVCTTELGAFAKLKDEFKKRDVKMIGLSANGLDSHAEWVKDINELSSTQLSFPIIADADRKVAFLYDMVDQRDLDASETGIVFTIRSVFIIDPNKKIRLTMMYPASTGRNTSEVLRVIDSLQTGDKKGVTTPIDWQVGDDVIVPPSMSTADAKQKFGQVREVKPYLRYTQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M3CMB4</accession>
    <name>M3CMB4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dynamin GTPase</fullName>
            <ecNumber evidence="3">3.6.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">SEPMUDRAFT_146943</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.5" evidence="3"/>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF14918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763039.1">
        <property type="nucleotide sequence ID" value="XM_016903979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CMB4"/>
    <dbReference type="STRING" id="692275.M3CMB4"/>
    <dbReference type="GeneID" id="27901116"/>
    <dbReference type="eggNOG" id="KOG0446">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008640_0_0_1"/>
    <dbReference type="OMA" id="PLKMGYV"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030061">
        <property type="term" value="C:mitochondrial crista"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097002">
        <property type="term" value="C:mitochondrial inner boundary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
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        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901612">
        <property type="term" value="F:cardiolipin binding"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140523">
        <property type="term" value="F:GTPase-dependent fusogenic activity"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180020">
        <property type="term" value="F:membrane bending activity"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070300">
        <property type="term" value="F:phosphatidic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080025">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate binding"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015886">
        <property type="term" value="P:heme transport"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097753">
        <property type="term" value="P:membrane bending"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097749">
        <property type="term" value="P:membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990627">
        <property type="term" value="P:mitochondrial inner membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990626">
        <property type="term" value="P:mitochondrial outer membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031623">
        <property type="term" value="P:receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000741">
        <property type="entry name" value="Putative mitochondrial dynamin GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056495">
        <property type="entry name" value="LIS_MGM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF212">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24550">
        <property type="entry name" value="LIS_MGM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13 17" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="20">
        <location>
            <begin position="258"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="19">
        <location>
            <begin position="831"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="178"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="923"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="923"/>
            <end position="939"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
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            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EMF14918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="945" mass="104568" checksum="6540247A8D53BE1F" modified="2013-05-01" version="1">MTSRLLSSRLSLPTKTALARTPPPRPILATARCLLPATRSTTHSALSGSHSPLRRWTQRKIWPAGANAMHNLPAVRHASFARVIPKLFVKLVRIPAMMGLTIAGGLAYVQYQTAQAGAYAVDLFGRAKDATVGAVNGVLGGLGDVFAQVSKGAERTKEDAKAIQMPQWMKDIYEGRADREEGGEGGGGRGRGPNEPQQSRVGAAGAGAATAAAFALDSDGEEDDRARDEAARDDQMMLLTRKMIEIRSLLQTVGQSETMTLPSIVVVGSQSSGKSSVLEAIVGHEFLPKGSNMVTRRPIELTLVNTPNVAAEYGEFPALGLGRMTDFSQIQKTLLDLNLAVPEKDCVSDDPIQLRIYSPNVPDLSLIDLPGYIQVEAFDQPTELRTRIQDLCDKYIQPPNIILAISAADVDLANSTALRAARRADPRGERTIGVVTKMDLVDPVRGAQILSDKNYPLRLGYVGVVCKVPQESRSLFSRGAQNITSLITKNESAFFSAHPETYGPESKANVTVGTPALRKKLMHVLESTMSASLKSTSEAIHHELAEALYEFKVQYNERTLSAESYLAESLDAFKHEFKKVSEQFGRQQVRDIVKRELDQQVLNLLAQRYWNRPVDDLRPVDQSSESIQEPLQSLPKADPENPLWHLKLDASTSTLTKLGIGRLATTVTAQALHSAVQGLIYSTPFASHPFAVQAITAASENILKDLAYDTSDELEICVKPYKYRVEVSDQEWKQGRENISKVLKDELQSCESALKSVEDQIGSRRKAKDVLAFIDRVRKGETILEGNGVGGAGGFSSALLEKGKEALFLRDRSDILRMRLMAIKSRQCAQASNKYYCPEVFLDAVAEKLTSTADLFLDAELLSKFYYQFPRILEKWGRDLDESTVERFAREDPKIRRHLDVVRRKELLEHVLKEMEGLRQLEAREKRSSQRGTQTDERKRKGWLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M3CMC8</accession>
    <name>M3CMC8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutamine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SEPMUDRAFT_146957</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(Gln) + L-glutamine + ATP = L-glutaminyl-tRNA(Gln) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20121"/>
            <dbReference type="Rhea" id="RHEA-COMP:9662"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.18" evidence="2"/>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF14943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763064.1">
        <property type="nucleotide sequence ID" value="XM_016903988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CMC8"/>
    <dbReference type="STRING" id="692275.M3CMC8"/>
    <dbReference type="GeneID" id="27901125"/>
    <dbReference type="eggNOG" id="KOG1148">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001882_2_3_1"/>
    <dbReference type="OMA" id="TWCIYPM"/>
    <dbReference type="OrthoDB" id="10250478at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004819">
        <property type="term" value="F:glutamine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006425">
        <property type="term" value="P:glutaminyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.10:FF:000007">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000037">
        <property type="entry name" value="Glutamine--tRNA ligase cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.10:FF:000015">
        <property type="entry name" value="Glutaminyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1160.10">
        <property type="entry name" value="Glutamyl-trna Synthetase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.800.10">
        <property type="entry name" value="Glutamyl-tRNA Synthetase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020061">
        <property type="entry name" value="Glu_tRNA_lig_a-bdl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049437">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF4">
        <property type="entry name" value="GLUTAMINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20974">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="11">
        <location>
            <begin position="96"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="11">
        <location>
            <begin position="278"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding" evidence="12">
        <location>
            <begin position="492"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA synthetases class I (E and Q) anti-codon binding" evidence="13">
        <location>
            <begin position="602"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="720"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="413"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="720"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMF14943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="749" mass="82776" checksum="9BD5864C17E1E7B6" modified="2013-05-01" version="1">MADHPPAPPAPPPAPSADAPDGAPKISKRAAEKEAKKAAAKAAKAASKSAPQAAPAAAAGGGADSSKKSSQADPVDPFKTGWLKGVYSEKPVAPAQVQTRFPPEPNGYLHIGHAKAITVNFGFAKSYGGKCNLRFDDTNPAKEEEQFFTSIKDMVSWLGFEPARVTYSSDDFDRLYELAEELIKKSKAYVCFCSAAAIQAGRGGKEHGPRSVCEHWSKSVDANLAEFRGMRDGKYEAGEALLRMKQFLGTKPEEYEVAEEDSAEVKREKDKLRRLANNPALWDCAAYRIKKDNYHHRTGLKWRIYPTYEFTHCLCDSFEGITHSLCTVEFETLRPAYDWLLEALNHKLPGSDEKGPMQREYGRLNVEGTILSKRRIAMLVNGTTVGQDSDPVDEAADAIDQMNLEEEGDEEPMTTTEVSKAVTSGTGRKIPPVVRDWNDPRLFTLVALRRRGVPPGALKKFVFDLGVTKANANTMTHTLDATMRTYLERTVPRLMLVLDPIKVTFTNLPDDYAESCVVPFDPKDKEKGDHTVPFTKTIYIDRDDFREEDDPDFFRLSPGQSVGLLHVQHPIKVISLSKNAEGKVDEIKAEYGKDVPLGKARIHWVGESKSENSPIKVECRVFNSLFKTTKPNELDWKSGGYYDDVNPESEVIYKNALVEVGFREIQQRAPWPKTEGETSGNADKSSVRFQGLRTAFFAEDQDSTPEHIVLNRIVSLKEDTSKKDVGATGEKKAAAGGNKGNKKAPAAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M3CMH3</accession>
    <name>M3CMH3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Lem3/Cdc50</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_147000</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CDC50/LEM3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763124.1">
        <property type="nucleotide sequence ID" value="XM_016904019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CMH3"/>
    <dbReference type="STRING" id="692275.M3CMH3"/>
    <dbReference type="GeneID" id="27901156"/>
    <dbReference type="eggNOG" id="KOG2952">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025025_0_1_1"/>
    <dbReference type="OMA" id="TWNNDQP"/>
    <dbReference type="OrthoDB" id="340608at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005045">
        <property type="entry name" value="CDC50/LEM3_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926:SF0">
        <property type="entry name" value="CDC50, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03381">
        <property type="entry name" value="CDC50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015840">
        <property type="entry name" value="DUF284_TM_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF15003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="432" mass="48071" checksum="886969DA99EDAB02" modified="2013-05-01" version="1">MSQTTQVQQQTDANSTQGSEEVDKKDQPKSRRPPNNAFRQQRLKAWQPILTPRTVLPLFFAVGIIFAPIGGVLLWASSTVQELIIDYSDCNATAPICPELERIPSGKISSHFKNSTDTAQAPQWCKETDVQVGFPLNSSLPSVHNVSTTQCHLQFYVPDRLSGPVLLYYQLTNFYQNHRRYVQSFDQDQLKGNFRDNGSISGSNCDPLERGKVNDSDSVEKPYYPCGLIANSMFNDTFAMPVLLNAPGSASPNITYNMTNENIAWSSDAALYGLAPYTPDQVVPPPNWRVAYPVGYNEDYPIPNLKIWEEFQVWMRTAGLPTFSKLALRNDNEAMEIGTYEMVINDYFPVTIYDGTKSILLSTRTIMGGRNPFLGIAYIVVGGLCILLGGLFTVTQLIRPRKLGDHSYLSWNSEGPSTATTTGRAPRPNEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M3CN90</accession>
    <name>M3CN90_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_123588</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Plays a key role in the late stages of endoplasmic reticulum to Golgi traffic.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the multisubunit TRAPP (transport protein particle) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
            <location evidence="7">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763379.1">
        <property type="nucleotide sequence ID" value="XM_016901853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CN90"/>
    <dbReference type="STRING" id="692275.M3CN90"/>
    <dbReference type="GeneID" id="27898990"/>
    <dbReference type="eggNOG" id="KOG3315">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073154_2_1_1"/>
    <dbReference type="OMA" id="YMVKFDD"/>
    <dbReference type="OrthoDB" id="10263222at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990070">
        <property type="term" value="C:TRAPPI protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14943">
        <property type="entry name" value="TRAPPC5_Trs31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.20:FF:000002">
        <property type="entry name" value="Trafficking protein particle complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016696">
        <property type="entry name" value="TRAPP-I_su5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20902">
        <property type="entry name" value="41-2 PROTEIN ANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20902:SF0">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017479">
        <property type="entry name" value="TRAPP_I_complex_Trs31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6 7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF15258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="228" mass="25396" checksum="CE3D77198DCE8CB2" modified="2013-05-01" version="1">MPGMSGPPPVPQKDNYVPITQAKPFVSTLRYPSNRKTIYDRNLNRAKTSEASLASFAYLFNTLITYHHAKSGSVSEIETRLNRAGYPIGIKMLDLVLYRLPPRTASRPTRMLDLLQFIHGALWRALFNRSADALEQSNTKKNEYMIVDNEPLVNTFISIPKEMSQLNCAAFVAGIIEGVCDAAGFRTEGVTAHWAGEGDEMWPGKTIFLLRFKESVLEREDAIKAGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M3CUQ0</accession>
    <name>M3CUQ0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_112259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456289">
        <property type="protein sequence ID" value="EMF07892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756013.1">
        <property type="nucleotide sequence ID" value="XM_016900965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CUQ0"/>
    <dbReference type="GeneID" id="27898102"/>
    <dbReference type="eggNOG" id="ENOG502S31A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025896_0_0_1"/>
    <dbReference type="OMA" id="RTHIQST"/>
    <dbReference type="OrthoDB" id="3793118at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF07892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="40015" checksum="03C9B6D0C56E291B" modified="2013-05-01" version="1">MSFKRIYQKDLNEILFGVWDEGVNHNVPLARVLVFGETTAIYQQTFERLSRTLDSATGKPLRFRHIHQEGISAVMMDMSSKQASGLGRFLEVLAPQMDWRTHIQSTVIYCSVHFTRSIHRAVGKDYSPVIEKMQSLRSVTSQVAYTQVIADLMKHEKAEIRNWAKNKASPIIRPGINHVWSTMPLSTYRSIRGHSNSIESIGMQSYRAGQRMDLLPAIFSAAIIDQRIHTSRIIQFQTGILNRSRNDGPVALWRKRTFTQQENDPDDFINTPATEPSSSAAVDRLDSSPIKQSQRTLSTPSRKDAEKALELEERKLALEEKRERVRLMRLQNEQMERYLEESSRGSIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M3CV16</accession>
    <name>M3CV16_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative isomerase YbhE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_152309</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cycloisomerase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF07992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756113.1">
        <property type="nucleotide sequence ID" value="XM_016907366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CV16"/>
    <dbReference type="STRING" id="692275.M3CV16"/>
    <dbReference type="GeneID" id="27904503"/>
    <dbReference type="eggNOG" id="ENOG502S3WY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038716_0_0_1"/>
    <dbReference type="OMA" id="FVWTATR"/>
    <dbReference type="OrthoDB" id="9972196at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050282">
        <property type="entry name" value="Cycloisomerase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011045">
        <property type="entry name" value="N2O_reductase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344:SF1">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50974">
        <property type="entry name" value="Nitrous oxide reductase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032618" evidence="3">
        <location>
            <begin position="22"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF07992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="419" mass="44080" checksum="2CE4BF6DC5E52DD8" modified="2013-05-01" version="1">MRLSSPTSPTLLALAATAASALNLFVADYSGSITTLSLSESNSSYTLDKTFETTACGPSPAWLTLDVNRGLLFCVNEGITTPNGSLSSFTINANGSLHLISNLTTLGGPVSSALYGNPAAAEHGIVLAHYGGSAVSTFTVSAGGNLTLNEEFVFEDMPSPGPDPERQDKPHPHQALLDPTGQYILVPDLGADLVRIFGWDVADLKLKELEPLVADPGSGPRHIAFWTPQNIPGGTTYMYLVEELSSRVAGYAVQYSTDYSGLSFNPIGSQSTLGYHNLVRRNAPAEIQISPDNKFLLVSNRNSTAFTLPDPEIGPSDSISTFQLCPNTGSLSARHHQLSPSGGLYPRHFATNSAGNLVAAALQLSGSVVILERDTATGLMMLEPVARIAIPANVTTVMWDEVARSGVTGLTGMGVGLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M3CVI1</accession>
    <name>M3CVI1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF171-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_136954</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF08162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756283.1">
        <property type="nucleotide sequence ID" value="XM_016902816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CVI1"/>
    <dbReference type="STRING" id="692275.M3CVI1"/>
    <dbReference type="GeneID" id="27899953"/>
    <dbReference type="eggNOG" id="KOG3925">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017233_2_0_1"/>
    <dbReference type="OMA" id="FFPIHKD"/>
    <dbReference type="OrthoDB" id="361029at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18086">
        <property type="entry name" value="HsC9orf114-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003750">
        <property type="entry name" value="Put_MeTrfase-C9orf114-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12150">
        <property type="entry name" value="CLASS IV SAM-BINDING METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12150:SF13">
        <property type="entry name" value="METHYLTRANSFERASE C9ORF114-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02598">
        <property type="entry name" value="Methyltrn_RNA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF08162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="347" mass="37588" checksum="87D04E36822C0822" modified="2013-05-01" version="1">MPSHKSKKRKVDDDYSLGPDTSKPSAIFKPTGGRSFTLSLALPGSIIANALTHDQKTSLAGQIARACAVFCVDEVVVFDDGQAETRAPEHGGYTAFADPNFFLFHVLTYLETPPNLRKALFPMHPDLRTAGALPSLDMPHHLRAEEWCEYREGITTHSSSGKGKMPQTFVDCGLSQQVAIPGAIDPNTRVTVKLGHTSSDGYTISGLPVSPETPREEAGYYWGYSVRQASSLSAIFTECPFDGGYDVSVGTSERGKPLKSIIDQSSPTYVEPTWKHLIVVFGGVAGLEAALKADSELQSAGVSQAEEVFDSWVNLVPNQGSRTIRTEEAVWVGLSGLREAVEIRSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M3CWL9</accession>
    <name>M3CWL9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7598 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_53836</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756648.1">
        <property type="nucleotide sequence ID" value="XM_016909278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CWL9"/>
    <dbReference type="STRING" id="692275.M3CWL9"/>
    <dbReference type="GeneID" id="27906415"/>
    <dbReference type="eggNOG" id="ENOG502SAQI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066685_1_0_1"/>
    <dbReference type="OMA" id="YARNWPL"/>
    <dbReference type="OrthoDB" id="5327148at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056019">
        <property type="entry name" value="DUF7598"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24535">
        <property type="entry name" value="DUF7598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7598" evidence="3">
        <location>
            <begin position="12"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF08527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="326" mass="35623" checksum="2D3BE7D240570C06" modified="2013-05-01" version="1">MTLSPKTLSGAGYIILNGIRAMNIIAFLAVITASVVMLVKTNTDTHLFFFDALSHVITLISSLFLITSELPIFKGYFARNWPLLSPSRGFVTLAVAMIVIGIQVMGNLNKSAGSQQALGMPFWRIVIASGILVFTLGWINLLASYIFRDTKQSITARMVRSHGAVAIHKTPKSISTDSCGSRTPPAPVLAQSYIPNPITPSPTKTTPHRFNFLNPDRRESGLPSYRTAAAAASPSVCHTTGDAPRSPESKYSRATVCTKKKVFGMFGRQSRQSLAPPLPINIEHREMEISSPMGVNPQFAHLVQRPDSAMHPSRSTGESEAFRWRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M3CXF3</accession>
    <name>M3CXF3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_151720</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756908.1">
        <property type="nucleotide sequence ID" value="XM_016906999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CXF3"/>
    <dbReference type="STRING" id="692275.M3CXF3"/>
    <dbReference type="GeneID" id="27904136"/>
    <dbReference type="eggNOG" id="ENOG502S41E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028685_1_0_1"/>
    <dbReference type="OMA" id="PNRHDIC"/>
    <dbReference type="OrthoDB" id="20729at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23954">
        <property type="entry name" value="AMO1_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051767">
        <property type="entry name" value="Nucleoporin_NUP42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041367">
        <property type="entry name" value="Znf-CCCH_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46527:SF1">
        <property type="entry name" value="NUCLEOPORIN NUP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46527">
        <property type="entry name" value="NUCLEOPORIN-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18044">
        <property type="entry name" value="zf-CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="151"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="250"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="214"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="323"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="358"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="418"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="437"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF08787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="549" mass="56403" checksum="E9974420849974B4" modified="2013-05-01" version="1">MVVCKFFQQGRCRYGDSCHNEHPQANRFAPLANQGGSGAFGSRGRVNGNAEDNPFFLLSEDIRWDLTWRRDNEKGERPLYPFGAYGPGKGAPKQLIEGELELSPEELRVQAYLANANGQLPQFQAQYAQLENLMNTKVQNILQNTEDARRFAGDTSHPNRNDSNIKPAGGTWPYRLGQTQSSSSSGFGMSAQPSQPSSAFGAASRPGFGSASQPAFGAPSMPSSGSAFGAPSAGAGGFGAPSALGSKPSPFGTGASAAPSTGFGAPSALGSKPSPFGATQQAASPFGAPQQAASGFGAPSAIGARPSAFGAPQQPASGGFGAPSQPAFGSSGFGSSAARPAANPFAAPAAQSGGGFGSQQPAPQTNSSPFGGSQQQQAQTAGSAFGAPSAFGAARPSAFATAAQQQQPQTGLNRPSPFAATTSTFGATSLGAGAPQSAGTPQAGTPTTWKGHRVVRDEKLDTPGYVVQDATAPNGQGIERIWFLSGPPDISEKLNAMTEAPAAVYEDPAIGPKLKEIYEWTAQHGTFVKDGAIMMPEIPPKREWCTFEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2022-12-14" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>M3CXF8</accession>
    <name>M3CXF8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_120693</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756913.1">
        <property type="nucleotide sequence ID" value="XM_016901629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CXF8"/>
    <dbReference type="GeneID" id="27898766"/>
    <dbReference type="HOGENOM" id="CLU_1338249_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF08792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="205" mass="22309" checksum="C73B640643101A18" modified="2013-05-01" version="1">MFTVNNASGNCGSKWEDGDAAYPYLCHAYLIQPSAAIRMVHRKRNSATSNRTSLVAPPLRSLHLHTVHMPRSPRESAKAHTLYNLVSTFAMLPSETDRESPPLTAVGAGRFLESEHISSLPVSTGQARPHPPRAADAVHAARTILPRDGQPSRHARFDAAIRSARHAGREIRPNVRHAGHVAGSEHLESAALHSISTRAIEDPEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M3CYD7</accession>
    <name>M3CYD7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_151928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF09092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757213.1">
        <property type="nucleotide sequence ID" value="XM_016907132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CYD7"/>
    <dbReference type="STRING" id="692275.M3CYD7"/>
    <dbReference type="GeneID" id="27904269"/>
    <dbReference type="eggNOG" id="ENOG502SUGA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022835_1_0_1"/>
    <dbReference type="OMA" id="WTAFIDR"/>
    <dbReference type="OrthoDB" id="3945206at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="596"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="499"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="635" mass="72308" checksum="96BE4FB8B5D12B99" modified="2013-05-01" version="1">MMVDQDRTVEARMPLAREVELYTEEELDRHLEENGLTVMVQDPKNITPEFIQRLRDKKERSRESCTLDLDQVNALLQSVPTTTPDLFRNSPSPASTPSSLPQEEVDAECLRVETESYHILVNDGAHPPYPFHLLESFLWNPEQYLEHEEYGDIVYYWRVYESDKSERTCICAGHLSKWRVFRNVQKIIRERGVQSEPVLWAAASYTGGLETYVDHYGSIDGQWDFKKYAERLTRRLSKYGFTRQFQLERNLDRQDKLTTWIEYLGYEYRFYDYAATFVKRSQRRHDRGWKKLVDSNLLRPEETYDVICDVNTSFQHANEEERAEKAVQSATAAVSSTESIIARSDGSTTKLRQRLSAEQATLDAARGSLESIKTRNEAITEFLSPMREYFYQKDEARRHSALLRWIVRQIPTIELELNSPDNAENDPDRIQRLPETIEGQHSQEYLGTHAVGDKQSDSVQGAPSISSSLIPQSHKRRRSSFNNEPVSKRHKASPEEIVASSSAPNASPSVTARPATETRTTPGLETSKAPSGDSSRPLKPLRRSARIAQLATETKTTPGLGVSKIPSGDSSRPLKPLRRSARIAEIARKKAMSIETRIAPVEPRRSGKSTSVSVPRGSGRRRGRRRGAVGRVIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M3CYH4</accession>
    <name>M3CYH4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycosyltransferase family 2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_72841</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756852.1">
        <property type="nucleotide sequence ID" value="XM_016910003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CYH4"/>
    <dbReference type="STRING" id="692275.M3CYH4"/>
    <dbReference type="GeneID" id="27907140"/>
    <dbReference type="eggNOG" id="KOG2571">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020762_0_0_1"/>
    <dbReference type="OMA" id="KESQMDW"/>
    <dbReference type="OrthoDB" id="9876900at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050501">
        <property type="term" value="F:hyaluronan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085029">
        <property type="term" value="P:extracellular matrix assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030213">
        <property type="term" value="P:hyaluronan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22913">
        <property type="entry name" value="HYALURONAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22913:SF12">
        <property type="entry name" value="MANNURONAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13641">
        <property type="entry name" value="Glyco_tranf_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="565"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="590"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="624"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="667"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="694"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF08731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="767" mass="85964" checksum="159757369CA2ACBC" modified="2013-05-01" version="1">MEIADLIQPQQRLRSNVQLFSEKNQLQSTRSSRTALAGDDRHLTWYIEATPPSTRPTTPSGSVTSSSSCSSLNIGYCKGDEVNPRPLVSAQRLQSRFYESDDSICRAQGANIVKTPLESSHPGATTSVVPTAFDSTTVFDSPTRKPLVIDPFRAVFNVMFSLSLIGALIAGYAISLRVFDLGITSVGLYGTLFLIEYTTQVSCAIANRITVDRLAHRQAKKVRETEVSIAVVGYREDEQAWRHCLRSLQHQTLRPKCVIGVVDGDDEPDLSMANAFVDEFQSMAAPLIRLPILLSDLHRNTYFSNMPLDTRSLLAKAGSYLSGRYRPGHAEALALARQAVMNQVLEWDRKWSISSMEAVCFSQPHGHKRTAMFTAFSISLWALRTRDGVFTTDSDTLVQEDALDEMLTLLHSSPNIGGVTADVKIWNRAESLLTRLCAARYWFAFNIERACQSTWRCVGCLSGPMSMYRSCDLDTILGPWNLQTLGGKSTTFGDDRHLTNRLLALGLKTCYTHRTWCESESPTTFVRWISQQTRWSKSFFREAFWFPPSFAFHSPWLLLETTIQTLYPFILVATIFDLLFGSSNNQWRPLIWVIVMFGLALVKCIVALCISCDPWLLLFSTYSFIYFFGLLPTKLWALVTMNYTGWGTSARSSTERRREQSVWQRTFHVGHLAIWYIAIFVGLGFFISRLCGNLVFLSVGAVAFLLTIFLYWGSAEVVQCGVQIKKCLARIGVRRKSPSGAWAASAWAADSSLEKPPKAYLGRPESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>M3CYX7</accession>
    <name>M3CYX7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_150974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF09864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757985.1">
        <property type="nucleotide sequence ID" value="XM_016906515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CYX7"/>
    <dbReference type="GeneID" id="27903652"/>
    <dbReference type="HOGENOM" id="CLU_2924193_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="61" mass="7318" checksum="7A35607261E97C6A" modified="2013-05-01" version="1">MDGERSPGSRRVLHRATDSLPWPHTDPRWAQDASKMESRWVQERGKMRPEWDQSRSKMRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M3CZB2</accession>
    <name>M3CZB2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_111478</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF09001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757122.1">
        <property type="nucleotide sequence ID" value="XM_016900916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CZB2"/>
    <dbReference type="GeneID" id="27898053"/>
    <dbReference type="HOGENOM" id="CLU_1563851_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="171" mass="17494" checksum="EF6D1F89F323818B" modified="2013-05-01" version="1">MAELAHGGVAHVVVIVVFIVVVVVDDDDDDAGAAAAAADNDDDDVDMVVCGRSIRASVVAARALSLSAPIVAGSQRLGSACCSVSLSSPLTGRFTPVVVVSGSGSVIAPSQHPLRSTDFSSFHVVRGAIHAALVCRAPSKSRARMLAMPAAMSLTHRRDDADRASVAHKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M3D0S2</accession>
    <name>M3D0S2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_151134</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758204.1">
        <property type="nucleotide sequence ID" value="XM_016906620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D0S2"/>
    <dbReference type="STRING" id="692275.M3D0S2"/>
    <dbReference type="GeneID" id="27903757"/>
    <dbReference type="eggNOG" id="KOG0023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_20_1_1"/>
    <dbReference type="OMA" id="VIPFQEL"/>
    <dbReference type="OrthoDB" id="256333at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF8">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="11"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF10083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="369" mass="38980" checksum="ACF2C49A502AEDD1" modified="2013-05-01" version="1">MSEVNIPAKMKAIQVVEYKKPYEIREVETPSNLTENDLLIKIAVASNCHTDSMVQQGIFNAPLPLTASHEGGGTVVALGSGAASRGFHVGDRVMVGLPLHPCGSCGDCLGPENQTQYCTRIEGHVGVQSHGCFAEYVRADAASTTKLPDDVSFMSAAPLACAGRTVWRSVLKSGLVSGQWICFVGSGGGLGHLGVQFAKALGLKVIGVDARDEGLELTKHYGADVVVDARKGKEQVVKEVQAVTGGLGADSTVTLSDHKDAAAIACASTKMHGTMVQIAQPDNVTIPFAELIFRDIRIIGSLIASAEESKGMLDVIAKHGVTVTTEKFYGLDSIHDLVELVHGGKLKGKAIIVVDNEQIEHEKKLGAKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M3D187</accession>
    <name>M3D187_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_150225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759364.1">
        <property type="nucleotide sequence ID" value="XM_016906029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D187"/>
    <dbReference type="GeneID" id="27903166"/>
    <dbReference type="HOGENOM" id="CLU_455732_0_0_1"/>
    <dbReference type="OrthoDB" id="3644109at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF11243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="599" mass="65846" checksum="ACBA7BA8EAFE4917" modified="2013-05-01" version="1">MAPRTRQSYLTNPGSPLLRGLAATRTARRAPSASTTRDAPASQHGLSSGMTAPLYRADSSNPASNSGDDDLSPSGTDGSPPPDPDSDFDPPPSNDGSSHGSPPPGSHSGGDSDPPSNNGSAHGSFAPDNTPFQRMRRNLWRAFKWTIPKLMVAVVQALLLRQVYVLLDLPVSAPVDFLYFKYYVSFRYVKGDSQAAASRILVDPLGTKHIPLIANSALSVDGVCNEQESTGLAFTVKQTISRTVLGAQSWEELMNASPEPELQELAQNYAHPISKGTSLIERAESVEKRMCRLSRAAMKKGLAYAQTRTLAEKLRGCRQVAQVLRPATRTLWENNIIEAIPGDWDYPIVTQAFADLETHLRRREVIARVLSDEAGELQTVYRQLVGNYSVFKWNLRQADSAVTQLCYQIEARKVEPSIWSKWWSKWFKGTDDASSCEVQTRAKFLRGGYNFSDTARLNGHAAMYYLKEGGDIWENYAKHLDDSLGLLSDVPKVLRDITAEGIPARISRLQDLFDSLAAQLDRAAEVLEDAHMRKIPIELTAHVGKEDDASIGARWPPEPIGCALCDGPREAEWHASTSLRFYMPDSTAEESVASTATNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>M3D1T8</accession>
    <name>M3D1T8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Multidrug resistance-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_150395</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759589.1">
        <property type="nucleotide sequence ID" value="XM_016906146.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.M3D1T8"/>
    <dbReference type="GeneID" id="27903283"/>
    <dbReference type="eggNOG" id="KOG0055">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_17_2_1"/>
    <dbReference type="OMA" id="YFVAYAT"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000913">
        <property type="entry name" value="ABC multidrug transporter SitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000604">
        <property type="entry name" value="ABC transporter B family member 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF18">
        <property type="entry name" value="ABC TRANSPORTER B FAMILY MEMBER 11-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="724"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="768"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="841"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="875"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="950"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="990"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="99"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="415"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="728"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1073"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="675"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1039"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1046"/>
            <end position="1059"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF11468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1316" mass="141833" checksum="7A76513E6A640768" modified="2013-05-01" version="1">MTSLHGSRQHSLRESLELHPSQLQAEADVERTTSVFTSEPLPEPQVPALDAARVSTWRTPVTALSKKVFGQLLGTNPFKNSYLDLYDPLESKTHKAIAIGSAIFAIAAGVPLPIIGYIFGKIINNFPPEPDALTQRLIQLIGVAIAYFGATTIYTIGFGLTAENVSLKLRQQLLRCLLHLDQAYLDTHDIDVNGLLTEKMDTVQAGCSEKVGIFIQAISYFVAAFIVGFILDARLAGILLASVVPAVTISFVVLSPAVSKCSKTVTKKNERANEVVESALGAVRIVQAFDMVEELCRRHTQNVDEATRANLKKAALSALQAAMVYFIAYSANALAFYLGSREASGGYAGTVYAVVFLILDASFVVGQFAPFLEIFARAASAKSTIQDLIDEGSTAYSAGTYRRTELRPDFARCDIEFKGVEFQYPARPTVKTLKGLNLHLKAGTFTSVVGTSGGGKSTLVALLLGIYDYSGRIDIGGNDVKAIDSTYLRSRIAVLDQDSILFSGTVFDNVCYGLLGQDVSEDEKQARFDQALKDANVDFLHQLPNGVHTRLGNETALSGGQRQRVCLARALIKRPSVLILDEPTSALDARSEVAVVEAVKKIAATGVTVMMIAHRLSTTLDSDLVAVVSDGEVVEHGTPRALAMKEDSVFRGLLNAQNTTFDDVNGTADEEKLALEASPTKSSTVSLAPRPSTHGKQPDAADSPAQLGLWTIAKRIGSIAKSEGLLAVVGLFASTVSGGILLGQALVFGHLITLLNDGTSNPNYYSRADFFCLIFFVLALVALASYLTSGTVFGMISSKITGRVQTRLLHTLLQLDVAWFSESGHSVQQLMSKFTKDPGDLSALGGVALGAIFTIFTSVIGGIILSMIVAWKVSVVLLAAVPIMLVAGWARLRLLTESETQHREAYTNATALAAEACRNRRAVTALCLEQHLIDDYQKALRAPFQKLRRFVYYANTLLAFCFSITYFVYALAYWWGSKQVRNGMYTTTDFFIVLPALLFSAQSAGQFFSLSPEIARAKTASRSIFTLLDAQPTIMQSQIRPDSLETKSGSTTSSLVSSDLGKSSNLDEVKPKVEFKDVTLLYPNSSKASLRNISLSIAPGQTVAFCGPSGAGKSSAMALIERFYDVTEGSLFYDGRDVRELDVRLLRSHMGLVSQDPDLFSGSISYNVKLGAPPGMPVTEDDVQAACKKCGLHDFITSLPEGYNTECGSSSASKLSGGQKQRLAIARALVRNPEVLLLDEPTSALDAHSEAHVQESLNEAAKGRTTIIVAHRLASIQHADQIFVFDGGKCVARGTHAELMQEAGLYATMAKAQSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M3D335</accession>
    <name>M3D335_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycine cleavage system P protein</fullName>
            <ecNumber evidence="7">1.4.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_150453</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GcvP family.</text>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="7"/>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759673.1">
        <property type="nucleotide sequence ID" value="XM_016906185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D335"/>
    <dbReference type="STRING" id="692275.M3D335"/>
    <dbReference type="GeneID" id="27903322"/>
    <dbReference type="eggNOG" id="KOG2040">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004620_3_1_1"/>
    <dbReference type="OMA" id="RNLICTC"/>
    <dbReference type="OrthoDB" id="6537869at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016594">
        <property type="term" value="F:glycine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00613">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000005">
        <property type="entry name" value="Glycine dehydrogenase (decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000007">
        <property type="entry name" value="glycine dehydrogenase (Decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000007">
        <property type="entry name" value="Glycine dehydrogenase (decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003437">
        <property type="entry name" value="GcvP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049316">
        <property type="entry name" value="GDC-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049315">
        <property type="entry name" value="GDC-P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00461">
        <property type="entry name" value="gcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003346">
        <property type="entry name" value="PRK04366.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773:SF1">
        <property type="entry name" value="GLYCINE DEHYDROGENASE (DECARBOXYLATING), MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773">
        <property type="entry name" value="GLYCINE DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21478">
        <property type="entry name" value="GcvP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Glycine cleavage system P-protein N-terminal" evidence="9">
        <location>
            <begin position="80"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine cleavage system P-protein N-terminal" evidence="9">
        <location>
            <begin position="548"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine dehydrogenase C-terminal" evidence="10">
        <location>
            <begin position="871"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR603437-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF11552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1059" mass="115888" checksum="C77E7208A0D48346" modified="2013-05-01" version="1">MSTTAIRLRAQWLATRRPLSTRCMLNKPTIQTRPYHISPAQPDSAHTRTRGFYSSAPRDSELEVKSHDSSIFAPLDTFPRRHIGPTATTTEEMLQALDPPVKSLDEFVKQVLPESILTTKDLNVEGPVPESGSVPTTEGGFSESQLLARLREIAGENKVYKSYIGCGYAGTRVPEVIKRNILENPAWYTSYTPYQPEISQGRLESLLNFQTMVTDLTGLAIANASLLDEATAAAEAMTLAMNTIPASRLKKMEKKVWLVSHLAHPQTIAVLESRAQGFGITIEVADILADGCKRVDELSNSLLGVQAQYPDTLGGVADYKNLADKVHQYQGTFAVGTDLLALTLLTPPGEFGADVAFGNAQRFGVPFGFGGPHAAFFAVSDKHSRKIPGRLIGLSKDRLGNNAARLALQTREQHIRREKATSNVCTAQALLANMSAMYAVYHGPHGLKKIAEKVAKMTQVLAKGLESGGLEVRQPVAFDTVVVRKHDAPGFAAKCVSNFLTNFRVIDDDHIGITIDETVGKKQIDQIFKAFTTDAIDIEGLAQGVEANAQVPKSLKRTSAFLTHPVFNSYHSETEILRYMHHLQSKDLSLVHSMIPLGSCTMKLNATTEMIPITWPEFANIHPFAPSEQTKGYQTLIKELEDDLAEITGFHSVSLQPNSGAQGEFTGLRVIRKFQEQQPGKKRDICLIPESAHGTNPASAAMAGMRVVTIKCDTKGTGNLDIADLEAKCEKYSEELGAFMVTYPSTFGVFEPEVKRACEIVHKHGGQVYMDGANMNAQIGLCSPGEIGADVCHLNLHKTFCIPHGGGGPGVGPIGVAEHLAPFLPGHPLVANVGGKQATAPVSAAPWGSASILPISWAYIKMMGARGLTHATKITLLNANYIMSRLQKDGQYDIAFTNANKRCAHEFILDTRNFKKSSGIEVIDIAKRLQDYGFHSPTMSWPISNTLMIEPTESESKDELDRFCDALLSIRQEIREIENGSQPREGNVLKMAPHTQQDLITSEWDRPYSREKAAYPLPWLKQKKFWPSVTRLDDAYGDTNLFCSCAPGGTVEDQPVQST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M3D353</accession>
    <name>M3D353_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_150467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759693.1">
        <property type="nucleotide sequence ID" value="XM_016906196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D353"/>
    <dbReference type="STRING" id="692275.M3D353"/>
    <dbReference type="GeneID" id="27903333"/>
    <dbReference type="eggNOG" id="ENOG502R947">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_476645_0_0_1"/>
    <dbReference type="OMA" id="LVWCLSD"/>
    <dbReference type="OrthoDB" id="26149at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="447"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF11572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="572" mass="62692" checksum="50935223D186C837" modified="2013-05-01" version="1">MSGVEAEGGGEMTSVSLAFQAISSINDAGPSNFSETAIALRSLAESSKKSESTRQQLSQPILLNTLTSLLYIHSSASSTLPDTDQETSAVIADSALRCIANTCTNNDNHTARDILCSSTTAAFFPWASAYLSSSQNDFSIRLLTTKVLNNICHQHEVSQRICYEEKVHWGLIRFLNEVCGKGLDDGELDGAINVLFEVSGQKTTTTKEAEMSPPLSSLPDDVLSALLNLHSIRNTAENDYVKPWSHDIETFATLSETILVFLRDEEIQKQIISNKLFPQVWQLLERQEKLISQIPREAEGGEEAEEDRKLMIPLQASLVWCLSDMAAIPAFATTYSHNSEVITQLTDVIHAAADTARRIRGNSSEHTRTADRCYPEKFQGLSASSQLFNAAAQILGNMLWTTQQQQQQQASPNGNPDVFSSPHAIISHTESIPYDLLDIVVSLPESLSTPNNSNPSTSPPSPSPDTADTLHSITGLLIQLSRPSIAIREEIGAYEYTAPAIRKMCGHAREEVRQGGVKLVKALGRECVENQRRFGEMVAEVARGMQQQQQQQQEGRPIVEEMDDGEGCSGNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M3D4C7</accession>
    <name>M3D4C7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_148435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761176.1">
        <property type="nucleotide sequence ID" value="XM_016904928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D4C7"/>
    <dbReference type="GeneID" id="27902065"/>
    <dbReference type="HOGENOM" id="CLU_973756_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF13055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="286" mass="31451" checksum="2C73CD6C2975C57C" modified="2013-05-01" version="1">MSHLYGGGKRTRARAVPPPLSPESKTIVPSATTTTNSASATATSTSQVAATPYNSTTTEWCAKEKACVANAREKELELAARQAYIERLEIQNTQLLSAMASCGWTGKPSNDHRESEAVVQRRNMPNKPAMFDRVKAWTSSCETRPKGLQGKETKIKQIKERAESFVASDMLHNGDIKTRTASTDLPLDVVAEPQLSAKHTLAPRKQDWNAKITAEFEAWERCKDNIVKTQNTIESEFGLIADAQDRYVAELNPIHTKRSIDHQDSAASLLMSSGNLSVPASKIARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2024-03-27" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M3D711</accession>
    <name>M3D711_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_116939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762051.1">
        <property type="nucleotide sequence ID" value="XM_016901297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D711"/>
    <dbReference type="GeneID" id="27898434"/>
    <dbReference type="HOGENOM" id="CLU_1939452_0_0_1"/>
    <dbReference type="OMA" id="YVELYIM"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032367" evidence="1">
        <location>
            <begin position="19"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF13930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="130" mass="12332" checksum="A8CDA91351AB44A7" modified="2013-05-01" version="1">MQFKYILAALLPAALVSAQAAAISSLLSEATADATSALQSISSEASVLSSSATQVATTANIASSAASSLDALTASASNAISSVLSEINSATSHVASKASSAINSATSHGGAAETAAPVLAAGIVAALAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M3D758</accession>
    <name>M3D758_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">CBFD_NFYB_HMF-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_148924</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NFYB/HAP3 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761835.1">
        <property type="nucleotide sequence ID" value="XM_016905231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D758"/>
    <dbReference type="STRING" id="692275.M3D758"/>
    <dbReference type="GeneID" id="27902368"/>
    <dbReference type="eggNOG" id="KOG0869">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066247_10_2_1"/>
    <dbReference type="OrthoDB" id="386949at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016602">
        <property type="term" value="C:CCAAT-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22907">
        <property type="entry name" value="HFD_NFYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000110">
        <property type="entry name" value="Nuclear factor Y, subunit B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027113">
        <property type="entry name" value="Transc_fact_NFYB/HAP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003956">
        <property type="entry name" value="Transcrpt_fac_NFYB/HAP3_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11064">
        <property type="entry name" value="CCAAT-BINDING TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11064:SF9">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00615">
        <property type="entry name" value="CCAATSUBUNTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00685">
        <property type="entry name" value="NFYB_HAP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="9">
        <location>
            <begin position="53"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF13714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="193" mass="21014" checksum="2BF1FFD62E0A5A94" modified="2013-05-01" version="1">MSQSPERNEDEGPATQTPENNDPAQQPNDQPGDEMNTRPEDLGYDFEVKEQDRWLPIANVARIMKLALPENAKIAKEAKECMQECVSEFISFITSEASEKCQQEKRKTVNGEDILFAMTSLGFENYGEALKIYLARYRENLVAKGGDKASGGATGAVHDASATFDNTNNGLGGPLEGGDSSTDFAYGTATGQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M3D7F2</accession>
    <name>M3D7F2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_148979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761925.1">
        <property type="nucleotide sequence ID" value="XM_016905264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D7F2"/>
    <dbReference type="GeneID" id="27902401"/>
    <dbReference type="HOGENOM" id="CLU_1469092_0_0_1"/>
    <dbReference type="OMA" id="RTHRYPA"/>
    <dbReference type="OrthoDB" id="4156665at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF13804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="184" mass="21034" checksum="D35BA2902E1499B2" modified="2013-05-01" version="1">MANKLTCLTRRTHRYPASMNWDKDFLAKPSSRTPHHPPPHTPVSATKEGKIRRRRSRPISHSDDVWLEDLMDTVEDIQSPLLFLPSHNGVDDDDGNEKKDMLANPTTTTTTTTAAVNPYANMSDKDRIRIKRRKVGKFIGLVGMETPVEEIAARIQSSLDRAMERSREELRRNEQIMTGRKKMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M3D9C9</accession>
    <name>M3D9C9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_82784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762605.1">
        <property type="nucleotide sequence ID" value="XM_016910318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D9C9"/>
    <dbReference type="STRING" id="692275.M3D9C9"/>
    <dbReference type="GeneID" id="27907455"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_1"/>
    <dbReference type="OMA" id="KCITIHA"/>
    <dbReference type="OrthoDB" id="5840532at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42820">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42820:SF1">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF14484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="274" mass="28858" checksum="00A5BA3C7268A0F0" modified="2013-05-01" version="1">MASLRSGPIAPGIAFVTGGARGLGNAIAVSFAREGSKGIALVDIQDEKTFEQGKAAVTKYGTKCITIHADVTKEDQVERAIAEAVKEFGRIDYAANFAGILGPVTPATETPLESWKNLMDVNLMGVWLCVKHQLKQMMQQNSVDVEEGRVPQLGSIVNAASVMSIQGSAGTGAYTAAKHGVVGITKSAALEAREHNIRVNAVSPGFLMTDLLKPFLAAGKIPADSWPHYEARQGRSASFDEVGDVVVLLSTPRMSLVNGHNLVIDGGFTINGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M3DAC8</accession>
    <name>M3DAC8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase</fullName>
            <ecNumber evidence="4">1.1.1.302</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SEPMUDRAFT_16908</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes an early step in riboflavin biosynthesis, the NADPH-dependent reduction of the ribose side chain of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NAD(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27274"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NADP(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27278"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; riboflavin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HTP reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.302" evidence="4"/>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762945.1">
        <property type="nucleotide sequence ID" value="XM_016908286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DAC8"/>
    <dbReference type="STRING" id="692275.M3DAC8"/>
    <dbReference type="GeneID" id="27905423"/>
    <dbReference type="eggNOG" id="ENOG502RZWZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036590_5_0_1"/>
    <dbReference type="OMA" id="HYLRYHH"/>
    <dbReference type="OrthoDB" id="5432at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="entry name" value="Dihydrofolate Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050765">
        <property type="entry name" value="Riboflavin_Biosynth_HTPR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011:SF7">
        <property type="entry name" value="2,5-DIAMINO-6-RIBOSYLAMINO-4(3H)-PYRIMIDINONE 5'-PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_8G06820)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="Dihydrofolate reductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="domain" description="Bacterial bifunctional deaminase-reductase C-terminal" evidence="14">
        <location>
            <begin position="59"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="18"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMF14824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="288" mass="30646" checksum="1D5D4D1A75177AF6" modified="2013-05-01" version="1" fragment="single">MSDVQRLEEDALRHLTAYLPPMPSSTHTDQDPSTVPQPELSHAPSSSQTTAAAAPTGLPFVTLTYAASLDSMIALAPGARTSLSGAESKAMTHYLRLRHDAILVGAVTAAVDDPGLNCRYPDATILDQPRPIIVDPNGRWKGMGKKAYQLAAEGEGQAPWVVTTSQTFEKKSRLQDIDGDYVIVDEKDADGAIEWYALLRTLFVRGIKSVMIEGGATVINSLLAQPNLVNAVIITIAPTFLGSGGVAVSPAATQTPADGGGQRTNAAWLDQPSWKQFGNDVVLCARLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>M3DAZ1</accession>
    <name>M3DAZ1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Oxysterol_BP-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_123579</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763366.1">
        <property type="nucleotide sequence ID" value="XM_016901852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DAZ1"/>
    <dbReference type="STRING" id="692275.M3DAZ1"/>
    <dbReference type="GeneID" id="27898989"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1737">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001040_1_1_1"/>
    <dbReference type="OMA" id="LPEMKGW"/>
    <dbReference type="OrthoDB" id="1854502at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120009">
        <property type="term" value="P:intermembrane lipid transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030011">
        <property type="term" value="P:maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13292">
        <property type="entry name" value="PH_Osh1p_Osh2p_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000281">
        <property type="entry name" value="Oxysterol binding protein (Osh1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000061">
        <property type="entry name" value="Oxysterol binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000001">
        <property type="entry name" value="Oxysterol-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF205">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="100"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="241"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="11">
        <location>
            <begin position="331"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="309"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="438"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="517"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="737"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="626"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="10"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="310"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="438"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="520"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF15245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1186" mass="131390" checksum="846145510622F03D" modified="2013-05-01" version="1">MAVPGDGPSASPNGSQYLSPVRQSIQSSHRPHLSTTMSNTQVIPGPSSPTNDSPITPSSATQGASIEQSVRLFKVFEALRNGDTAAIAKATRAEDGAKLEGTTILHLAIQCAEMAVIEYVLSQHDADINARDRDGNTPLHIAASLGRVPVVKLLLEQQDLNDSNANHQGKTALDVARSPEIFQMLRLARSVYIDQQVRTIHQLVAKGDYASLEELLNDSRVRSIIDINSPELATESATTADWGSLLHEAARKKDLKLAQLLLLNGADPFRRDRKGKLPQDVTKDDKTRAILKRSPAAAAAQRQIQEQTILGGGPQASGVPTGEGGPGSKESREMKGYLKKWTNYTSGYKLRWFVLEDGVLSYYKHQDDAGSACRGAINMRIATLQMDPKDKDKLHFEIHGKSSVKYDLKANHQVEAKRWFWALNNAIQWAKDEAKEEQRRERQEASAKHEQLERIRTREADVAHGGAGLTPGTAVSGLSTPVAASALGDGNLSAYDPSEADGGSVAIRNLSRTGTATIEGDLDDDEEYGDDASSHEIKPANKDAFSITAQSAKLQLDLLEQVSAALRSEKDKSPNTTLGHPTVAQALSSYEMAVGNLKGLLMDLLRISRDHEAYWQYRLDREQNVRRLWEDSMAKVAREQEELENRIGESEDKRKRTKKALKEALDGTAAASRAVSPLVAGGDTTQPLLDIPPGHAAKKRHTIAELTNNEISDDESEEEDEFFDAIDAGVVEVVDTLPEPPKSPGPTMAHKDGARDTSAVEAERQQKEQQISKSYRGYEDGLRKRLKIDADNRPKVSLWAVLKSMIGKDMTKMTLPVTFNEPTSLHYAVVADMEYTNLLNTAADRTDSSERMVYVAAFAASEYASTIGRVAKPFNPLLGETFEYVRPDEGYRFFIEQVAHHPPIGAAYAESSKWTYYGESNVKSKFYGKSFEFNPTGTWYLHIRPIDGSPEEVYTWKKVTSSVVGILTGNPVVDNYGLMEVKNWTTGETAVIDFKPRGWKASSAFHVSGKVLDKGGKTRWSLGGRWNDKIYARLTPGYEGSVGPSEGSAEKGDKAFLVWEAHYRPPLGEIPFNLTPFVVTLNDLPDKLRPLIAPTDSRLRPDQRAMEDAEYDLAAEEKTRVEEGQRARRRIREAKGEEFVPRWFAKAKHPVTGEEFWKFNHEYWQIRDEVAAGTRNWGSERLEEIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M3DCF3</accession>
    <name>M3DCF3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Autophagy-related protein 27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">SEPMUDRAFT_147362</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus membrane</location>
            <topology evidence="4">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Preautophagosomal structure membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ATG27 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763605.1">
        <property type="nucleotide sequence ID" value="XM_016904249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DCF3"/>
    <dbReference type="STRING" id="692275.M3DCF3"/>
    <dbReference type="GeneID" id="27901386"/>
    <dbReference type="eggNOG" id="ENOG502S1VT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047751_0_0_1"/>
    <dbReference type="OMA" id="GSSHWGF"/>
    <dbReference type="OrthoDB" id="29460at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018939">
        <property type="entry name" value="Autophagy-rel_prot_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071:SF13">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE RECEPTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09451">
        <property type="entry name" value="ATG27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0072">Autophagy</keyword>
    <keyword evidence="17" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="15 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 20" id="KW-0732">Signal</keyword>
    <keyword evidence="8 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032969" description="Autophagy-related protein 27" evidence="20">
        <location>
            <begin position="20"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="254"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="21">
        <location>
            <begin position="22"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="192"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EMF15484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="327" mass="36049" checksum="5F29D7D912A0F1B0" modified="2013-05-01" version="1">MPSISILTSWLLLPAAISAVTLDCENIVADNQKFNLKALGGPKDVHWVKPEPPGYLNTTWTIDICQQLKKPKEGDKAHSCPVGTQVCGVKRVYNDENDGGLVEVIPIAGEYLAGDHLAPKVTRLKHSSSNQDSKREGLRVELHGGVLVKQKQKAIVEFICDAEKEGTEGFEEEEKLMDVASYGQMNRRANGEGEDDGEGEGEDEPLPDLDAGKALQFISYKEEGDLGVLRLDWKTKYACEDAKQPPAKNKKGSWGFFTWFLIIAFLLIASYIIFGSWLNYNRYGARGWDLVPHGDTIRDIPYIVKDWTSGVAGKMGNGSNRGGYSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M3DEM2</accession>
    <name>M3DEM2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Vacuolar protein sorting 55 superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_106142</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OB-RGRP/VPS55 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764080.1">
        <property type="nucleotide sequence ID" value="XM_016900617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DEM2"/>
    <dbReference type="GeneID" id="27897754"/>
    <dbReference type="eggNOG" id="KOG2174">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134810_0_1_1"/>
    <dbReference type="OMA" id="ICARCAN"/>
    <dbReference type="OrthoDB" id="14246at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034424">
        <property type="term" value="C:Vps55/Vps68 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
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                <person name="Hesse C.N."/>
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                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
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                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">SO2202</strain>
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    </evidence>
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</entry>
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        <name evidence="2" type="ORF">SEPMUDRAFT_120549</name>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">SO2202</strain>
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        <source>
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    </evidence>
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</entry>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            <strain evidence="2 3">SO2202</strain>
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        <location>
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    </evidence>
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            <dbReference type="EMBL" id="EMF10406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="135" mass="15347" checksum="FD61B421580DAE13" modified="2013-06-26" version="1">MCYHKYTHYTHCGEHIPMHTHMCPKNITEDQTRVIFCEDYQAVRVEANADCPHCEPLSHPHHQYQHRHHHHHHHHHRAGSSPSSSSSSSVVVVPVTTPIISGRQRQQQQQRQQQQGGGGGHYPTPPKTATPGSTR</sequence>
</entry>
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    <accession>N1QDZ0</accession>
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        <submittedName>
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    <gene>
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    <organism evidence="7 8">
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            <taxon>Dothideomycetidae</taxon>
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    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
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</entry>
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    <accession>N1QE74</accession>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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                <person name="Grigoriev I.V."/>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7 8">SO2202</strain>
        </source>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    <dbReference type="OrthoDB" id="2502820at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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            <end position="60"/>
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    </feature>
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    </feature>
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            <end position="244"/>
        </location>
    </feature>
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        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMF10775.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="556" mass="59234" checksum="C66D1587DA95A089" modified="2013-06-26" version="1">MAGRASEYEKSRGAVLVQDVLIATKLVSARTWHRVVRAWLVMPIAVAAIMAVCFGVDRLINLGNVPFPASVACLILLFLALILCSFILGDRATKTMVGYLDVPCGWSLRFLNIFLCPGFVTLPLSPPISGAEVAKIIGVALVGWAVVFALSAYSVRGIVLLIGNSKKAEVARAEELGVHQDDIPLSRVSTPPDSRRTPSDYGESTPDESPNPSTPFLVQPPRAQNPDYVTGTGGPPIPESTRLSSETISPLSILRHDAPLQTRAEKWAAFIISQLDLLTYAALMVFIGIPVYYGLGYAMPLQLCISIITYEVATMLPLRWKTYLHPILVSSASTVLAIWVFVLTRGESLSDGLHAYSTGVKYTRLWSGAAIAGTLPGAGDILSSIIDVSIIALALPMFQYRHELQKNFLAIIIPNTIWPLASLFGYPAFCYAIGITPTSSLAFGARTLTLALGQIVVANVGGNMNVGTPLAIFSGIFGVLIGNQILKFLRIPEDDYITRGITFGANSSSLATAMLLGTDPRAAAFSSLSMGFVGTVAVAATSVPPIVLAVKGIVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1QF53</accession>
    <name>N1QF53_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Matrin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_149711</name>
    </gene>
    <organism evidence="10 11">
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        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3A3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759974.1">
        <property type="nucleotide sequence ID" value="XM_016905724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QF53"/>
    <dbReference type="STRING" id="692275.N1QF53"/>
    <dbReference type="GeneID" id="27902861"/>
    <dbReference type="eggNOG" id="KOG2636">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027160_1_0_1"/>
    <dbReference type="OMA" id="GPKAFQK"/>
    <dbReference type="OrthoDB" id="2160351at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051421">
        <property type="entry name" value="RNA_Proc_DNA_Dmg_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031774">
        <property type="entry name" value="SF3A3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024598">
        <property type="entry name" value="SF3a60/Prp9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021966">
        <property type="entry name" value="SF3a60_bindingd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786:SF2">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786">
        <property type="entry name" value="SPLICING FACTOR SF3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16837">
        <property type="entry name" value="SF3A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12108">
        <property type="entry name" value="SF3a60_bindingd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11931">
        <property type="entry name" value="SF3a60_Prp9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="9">
        <location>
            <begin position="418"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="238"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF11853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="519" mass="59773" checksum="75A9B9827F107BBC" modified="2013-06-26" version="1">MIYEDLRAVHEDIERLEQAIADRILDDHKHIRSRLVRDHEIANFLQRIQTQSQHAIRLYDEQESRTHEIQQISTGDTYATFYDELNKIKDFHKRYPNEPVENLERAYKRAEDGGPPGGFAGDINTIFTGEEAFGRFFDLTLPHEDYLNLPGVKNVRKLTYLQYLDNFDVFTPPKCIISPQEKMTDQYFAYVGSLAEYLETFLRKIKPLEDLDKLIKSFQDEFDKEWSEDKVPGWETTKAASNGTASTQPTTEGTGEGVWCADCQKEFKNDNVYKAHLTGKKHIKAAEARQQMLANGGEDTEMTNGNGPAGISLARVKERAVAEREYRIRALAKNMQTQREDTRVNVERKAGMTDKERQQELAALFEEENEAMSRPAHAEEDGDDEEEKVYNPLKLPLAWDGKPIPFWLYKLHGLGVEFTCEICGNYVYMGRRAFDKHFSEARHIYGLQCLGITKNTGLFREITKIEEAEKLWEKLERDRHRDLERKGGVDGDGIVEMEDPAGNIMPKRVYEDLAKSGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFC2</accession>
    <name>N1QFC2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_164316</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760109.1">
        <property type="nucleotide sequence ID" value="XM_016908109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QFC2"/>
    <dbReference type="STRING" id="692275.N1QFC2"/>
    <dbReference type="GeneID" id="27905246"/>
    <dbReference type="eggNOG" id="ENOG502S1AX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032494_2_1_1"/>
    <dbReference type="OMA" id="LFEWTRF"/>
    <dbReference type="OrthoDB" id="4708870at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF11988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="420" mass="48232" checksum="EA64DE333E4E808B" modified="2013-06-26" version="1">MGGAAFAHAAANGQPTLRTPRMSPEVYEHLKLTYLRRLKDYFPDREVITLREAPEKTDFGDIDFTIASDRPVDPMHLASALGAAAFLSYGGLHMLAVPVDGTKHPRIPVKYTVLKTAEPVDQLSEETYAQIDIDLVKPDLFAWHSFYSSYGDLSSILGQIVSNLGFTVTDKGMMLRLRELDDAKDNSVQLQISDKQGMLFLSNDPDQVMEFLGLNLRIYQAGFSSMNDFYAWLARCRLLTPDYVGNLQYKRRDTSNQRQKEYKRPAIKSFFEEYLPAHVGTECAEIEDPDMWRANLARRREQWRNEAVQFFKKREELEQMRVKLVKSISNQTADFLVKPIVSANYGGNKQKVHEIVRAMRRWVGFENGQPQILAESHSDEESQLHFWLEGDVLRDPAAVNTWIEENWARCKALERENRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFH6</accession>
    <name>N1QFH6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Glycosyltransferase family 32 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_150583</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endomembrane system</location>
            <topology evidence="10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758613.1">
        <property type="nucleotide sequence ID" value="XM_016906271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QFH6"/>
    <dbReference type="STRING" id="692275.N1QFH6"/>
    <dbReference type="GeneID" id="27903408"/>
    <dbReference type="eggNOG" id="ENOG502QW2I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022381_5_1_1"/>
    <dbReference type="OMA" id="DWADWYS"/>
    <dbReference type="OrthoDB" id="411251at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.20:FF:000002">
        <property type="entry name" value="Initiation-specific alpha-1,6-mannosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039367">
        <property type="entry name" value="Och1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834:SF1">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109817" evidence="12">
        <location>
            <begin position="27"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="28"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF10492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="399" mass="44562" checksum="47A9D60E2522D5EC" modified="2013-06-26" version="1">MLTFRRALAVAALILTCFLLLRNTHGLRQPSPPRINNSPKPTGTHADNRKIVEAVPEPAKGDASNTKPVASAIPEKSWKGDSAGRVALSKKPKPQIALSELKLKPLRQQLAYAFPYDAESRFPAYIWQTWKVTPASGEFHEEWRPAEASWTELHPSFVHEVITDSVAVHLIKHFYASIPEVVQAYEALPEAVLKADFFRYLILLARGGIYSDIDTTALKSAVEWVPPEVSRSTYGLVVGIEADPDREDWHDWYSRRIQFCQWTIQAKPGHPVLVDVVATITEEVHRRKKAGELHTTISGPASVVEFTGPALWTDAIFKFFNNPDYFDMSTSKGNITWQQFTGITAAKKVGDVVVLPITSFSPGVGQMGAKDVDDPMAFVHHTFEGTWKPESERHIGEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1QG70</accession>
    <name>N1QG70_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sec1 family superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_151525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757669.1">
        <property type="nucleotide sequence ID" value="XM_016906872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QG70"/>
    <dbReference type="STRING" id="692275.N1QG70"/>
    <dbReference type="GeneID" id="27904009"/>
    <dbReference type="eggNOG" id="KOG1300">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009210_1_0_1"/>
    <dbReference type="OMA" id="PFTRPHT"/>
    <dbReference type="OrthoDB" id="2228at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="615"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="626"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="644"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="687"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF09548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="701" mass="79781" checksum="B016D066680E4706" modified="2013-06-26" version="1">MGVSIIDAQRDIILNVLRQITRDDWKVLVVDPDSRKLIDNVIDQDVILNENIMSIELITDRRSTNRDADAIYLISPQAYIVDCIMADFEKRKYRRSHLVWTSLLPPALRERIDKSRFRDQIALFKVLNVEFYPRESHLITFRDPWSFPVLYHPACNTLVRQHLEDLAQKVVGVCVALGEYPTIRYYRPRTPTHEASILCSHLARFVQDELDLYAKFHEDFPPPTTRPRGALYIVDRSMDLYAPILHEFTYQAMAHDLLPIKEGDKVTYRMMVNEGQLDQEEKDVEITEKDKIWAENRHQHMVHVIAKLESDFKNFLKNNANFTNKEAEGVHLNTIKDMMAGLPEFQQMKEAYSLHLGMAQESMNRFQQRNLPDVASVEQILATGLDEEYKKPKGVAAQVIATLDEGGVVPPDRLRLLMLFMLFRDGMVPADLQKLIAHAQLSPQDGEVLQNLEILGARTTRNIKDSRPIPQPLFPKKPPPVTVQEEYALSRYEPVLQNLLEAHASNTLDPTVFPYTKPPLDMGDGLQRQETAASLRSAKPTWARTRTANSGLENRQRVIVFMAGGATYSEARACYDVGRQTGRETFLVTSHMLTPGLFIRQVGDLSADKRRLNIPAEMPKPQAPRHLFEPDEQPKPKAAPPVQQPQRAPVTQPPIQQMGAINLNGKPHGTGPSSSSGAITKEPEKKDKKKHHFGFGRSKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGB2</accession>
    <name>N1QGB2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phytanoyl-CoA dioxygenase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_36099</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764337.1">
        <property type="nucleotide sequence ID" value="XM_016908628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGB2"/>
    <dbReference type="STRING" id="692275.N1QGB2"/>
    <dbReference type="GeneID" id="27905765"/>
    <dbReference type="eggNOG" id="ENOG502SJGE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047725_0_1_1"/>
    <dbReference type="OMA" id="HRDDSIH"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF16216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="271" mass="30623" checksum="FB1402D3C416C4E4" modified="2013-06-26" version="1">MEKDIRPHLEADLPWEADTFFPPTTKRAFGLIGKSQAFALHVIGNELYQAVCDAFLTTKCYPYFGNRNIPNVSRPQVNNTIAFSVRPGNSYDQPLHRDDDIHYADRPRVERYPDQTNSRDFGVGFFVAVKKSTKANGATRFIPGSHLEATVQPPEEDFAVYAELEPGDGFIMLSSCYHGGSANKTTDEERLLVSCFMTRGYLRQEENQYLAVPIEKARALPPRIQKLMGYAPSDPMLGWVDFKDPRVVLDPEEKGRVGHQNMNKYAQAQTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGH0</accession>
    <name>N1QGH0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Galactose oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_145551</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764381.1">
        <property type="nucleotide sequence ID" value="XM_016903125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGH0"/>
    <dbReference type="STRING" id="692275.N1QGH0"/>
    <dbReference type="GeneID" id="27900262"/>
    <dbReference type="eggNOG" id="ENOG502RYQG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013054_0_0_1"/>
    <dbReference type="OMA" id="FQDQGME"/>
    <dbReference type="OrthoDB" id="5352000at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="640"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="734"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="795"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="332"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="541"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="650"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF16260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="837" mass="89667" checksum="B634303B271CD9AB" modified="2013-06-26" version="1">MSVPVPDHSLSGHCSGIHDQTLYVYNNDGQLQSLPLKKNATWTEELGGDVVNAPACVKATGSEPALFVVGGESDDASFRGVQKYSFTSNAWESLYPAADVLQNRVDHSVVYLPDSESILVYAGSQASAPSHLSSQTFLLSTQPPYDILSFTSNAPPANNPILAQWNSSHAVMVGGQTTSNQVWLFGPSEGWTQLSSDLAGPLDPSARAVVINGDDGSKVLQVYDLHTSPNTAQAVVLLGDGGRPAYTGQMVGQAQSLDSRKRDLTIADWPSYNATNAPTSTRAECSIAQGEDGLVVMAGGNENHPLIMYDQKENSWIDANDFFKAKQQVVLQPSSTSQPSATPTASETSQPTTTTPAGSNGMSAHQKTLRTLGITLGTLCGIAALFILILLFLRWRRTKQKKQNGGYLKEKEHDGAADRRLSFADRGASFMKEAGVSTHELTPPKANFDRSNGSHSSLAIITNKWTNGNKQSPYGHEQKASFESTARLVKSREAISRPSENHEMVDIGHKTAGPNSNLVVPGSFAHGSLDRETRDERKRSSGWSKYFASSTPEGANSLSHIPSAYIKPNTSGEGIDRDSEYSNDTQRARIPSSILMPPLDIDFTKTVDGQRLSHVAMGSPAFMDSREEFARTGSAGVVSEGQRGQIVDPRSSQATSINSYDNRSTIGSYVSSEYPHEAQTPWTPMSGDVASADRGRATSSVYSNGARVPSRGRSTGFFPGAGTSYKPAKAKLSHAAGPTSEWASPRTPSAARKPAESIMKPTDINDGLEDLAPPRAPGLSLRPAEDRDSTVTIFPGADYLDSPPKQGRGQAVAGAHQEVAGRHPINTDMSWFNPRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGZ1</accession>
    <name>N1QGZ1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_129424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764612.1">
        <property type="nucleotide sequence ID" value="XM_016902286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGZ1"/>
    <dbReference type="STRING" id="692275.N1QGZ1"/>
    <dbReference type="GeneID" id="27899423"/>
    <dbReference type="HOGENOM" id="CLU_311498_0_0_1"/>
    <dbReference type="OMA" id="CKEISAC"/>
    <dbReference type="OrthoDB" id="3650623at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40788">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40788:SF1">
        <property type="entry name" value="IPA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="770"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="794"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="827"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF16491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="943" mass="106908" checksum="7457A0C7E4AB3C30" modified="2013-06-26" version="1">MSARYRNEHKGIGDDYMLDAAMSHAYTLCTRACTDGRMTSSTPSQYLYRSHGGACSPNLGCATCDDNYLHVAPQSSDPAQCEPVGQSEALLTIKGHIESINNDWATICSLVAAKGDKIMGRWKRANSAKRDAMLHEAFGNAQEKQWAYLRAFYANPGPTNPIDSHRDALLLPYLSQRGLARDPSKLLVLLELRRQHAPCHWAWTDHRITRSGRRIGMLVVRFSDTVFSTGADDYGKPVEFDHELFHQWQQIGFPIAETLFEAQRKLYSRLAKMVSAILKGAEDTITGDIAWNAAAAEGFSALLPKAYNESGKFLHVPVTPFEPPPRTDVTELLASISTRQVAAEEELWLLQTDIRSVYDRVAYIENAKFLANLKADEKWAAIALELTRPLIRRVQFWATLRTCTEGWQMAMDHGMGHHETHYKLSKAKKLLEGADLVLAFIKFLFPKVIRKEFQDVMTGILAQDCYFDHEFATVDPALPEKSDLPFVRIPEESIRIIKESAPNEARKHLIKLRAMFYKVIRFSDFFERDPPVWAALLFSNCTRTMDLAIAEEVFPVMDELLVFPEENNVKLDLLKHSQLLPALKDFSVAIWVQKRLELHAPEVLSLNDEESDEYIEQPEWHQLLHELVSMKVKNGTDGEWYRDWVYRATPDEEVRLKLSKAGKLLEQFSKIKLPAEKRGVNYLVKSKEAKLALDAFWAEVREVRIDAVSTDLRECGQEKDITRAEVEALKDIRILDCYKDPGPLEIIEADLAPRLAGKGKRKVDEQQDLEILADQKHLQVSPPKKPRLRRKGEDDDDDEDDDDDDDASSSKKPLKRKHLPTPEEPAVTPPPIIDRPPTPPPIIIPASAKSIRIFARLWPAESRTVEEGAVTWNDLRAAMGDIGYPGVSIGGSCWSFQGPQGKVVMDTPHGTPHNRVERGKLMYCGRRLARAFGWNFETFVLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1QHC3</accession>
    <name>N1QHC3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Brix-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_108665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759950.1">
        <property type="nucleotide sequence ID" value="XM_016900748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QHC3"/>
    <dbReference type="STRING" id="692275.N1QHC3"/>
    <dbReference type="GeneID" id="27897885"/>
    <dbReference type="eggNOG" id="KOG2780">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040063_3_2_1"/>
    <dbReference type="OMA" id="HFSVSNW"/>
    <dbReference type="OrthoDB" id="45930at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10480:FF:000005">
        <property type="entry name" value="Similar to RNA processing factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044281">
        <property type="entry name" value="IMP4/RPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734:SF3">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="202"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF11829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="433" mass="49611" checksum="ADF681A51695934B" modified="2013-06-26" version="1">MGSFNPNKIGNKLKRNEQHQKLKREKENEKRDERMRRRRHEDKNPHLRDQRRAKNVPATIDQKRTWDEIDSGDEDDVGLGRAYDILDPKRRKLESVADVSELLPEEAKDDAEVPDADAKDVLPNDDDDEHDSMLDSDSEGEEADEAEDEDEDEDGISRRPAKRAPSEAPSIAPSAATGVTDLTVRPEALKAKFPSLFEDTDREPKVLITTSINSTLHHEGQLLTGLFPNSKYIKRTAHFHAYKYSIREICSYASDPDRGYTHVVILNEDQKRPKGIDIVHLPHGPMFHFSISKWIPGNKLPGHGNPTNHYPELILNGFRTPLGLLTAHLFKSLFPPRPEIQGRQVLTLHNQRDYIFLRRHRYVFRDKRGTEKPIQGADGKPMKGAEDIRVGLQELGPRFTMKLRRVDKGIQKASGQEWQWKAGDEKVRTRFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1QHI1</accession>
    <name>N1QHI1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_150658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758734.1">
        <property type="nucleotide sequence ID" value="XM_016906318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QHI1"/>
    <dbReference type="STRING" id="692275.N1QHI1"/>
    <dbReference type="GeneID" id="27903455"/>
    <dbReference type="eggNOG" id="ENOG502S3UT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052209_1_0_1"/>
    <dbReference type="OMA" id="TAFHLWS"/>
    <dbReference type="OrthoDB" id="5316527at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF10613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="436" mass="49967" checksum="C1C9276541764C9A" modified="2013-06-26" version="1">MHRLPRALTLRHQQQQQLAESVWRHATTTASRRCASRLPRSRPVSQIAHMRSGESVRFQAVRFKKPGFGKRQLITIALYGGTFYVYWRMISKYLGIEIEELEELDDGADEEGGEEVEEDDDGYAHPDSTFIPLTWPTKLPRTFYRGSDPEWQEFIKVAKDQPRHTRIQNELVQLVYRESIKHPGVARQLGKDTKVGKWWLDISFPDGPPQEYERSGIEISDTYIAWSQQRMSPENHFRMVRALWPKAAFDSLYATGRVLAGINYRRMKQALGWEGKDPFSPEERMRLAIETHNKRHHPNESSRKQVGQGQLEPNASPDAVSGSGVIDPAKSTSDEEKKLRSWMVDVPMPSGDQNSLDVPIAMIVMQNTLRKQWNPKNMEPPRGTFVVHGMVEVRGQRGRMKFDVRSCYDPKAGKFTSVNANVRSFKLVKQAPRGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1QHX2</accession>
    <name>N1QHX2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Wax synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_45383</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the wax synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760175.1">
        <property type="nucleotide sequence ID" value="XM_016908965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QHX2"/>
    <dbReference type="GeneID" id="27906102"/>
    <dbReference type="eggNOG" id="ENOG502SAIV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021051_1_1_1"/>
    <dbReference type="OMA" id="WHQTFRF"/>
    <dbReference type="OrthoDB" id="2796277at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044851">
        <property type="entry name" value="Wax_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032805">
        <property type="entry name" value="Wax_synthase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL O-FATTY-ACYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595:SF67">
        <property type="entry name" value="WAX SYNTHASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13813">
        <property type="entry name" value="MBOAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="461"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="493"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Wax synthase" evidence="8">
        <location>
            <begin position="380"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF12054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="569" mass="65011" checksum="556E4823CB639967" modified="2013-06-26" version="1">MLPPGLETPRQVQAYYDQRYNAYIDSGEYFPFIYPWATLGPLLCFVYLLFDHRQSPTLQALRFPIFGVLVAFSAWTIFNVKARSAPAAYGVGLVSAWGTLWIASLMFFNDCQRDFQRLERADEAALHKALQYQNGTTVTGPESDGKLQTTLSSAYATQLPCQRTGPVFWQSYPTQPFLSRLDWIMDLFCNFRGIGWNFQTSGIPKPPKYIELQLLGYDVVEEDEQDMTSPSSTSTTRNNNNPKLIKTVSYTGITRFITTSRHHLLQYIIPRLILQSLALDIIKTLMHHDPYFWGYTDSGPPLWLHHLLPQNNNTILTPIILQTYRLLLSLLGILLALNTIFRLSPLLFCQILRPQILGLRGEPLLNPVDFFGNFFPQICRHGLAGWWGGFWHQTFRFAFTCPTERILEFWCGGQQQHMEKKKKTARGKMVGVMVAFGLSGFLHACGSWTQLGDTRPVRGPWSFFMLQAVGIIVQTGIAGYMKARGWREKIPSWIRGMGNFAVTMIWLYWTAPLLVDDFARGGVWLYEPLIISPLRILGFGAYDDSGWNLWSGLVFWRSGRGWRDTGLAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>N1QHZ3</accession>
    <name>N1QHZ3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">R3H domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SEPMUDRAFT_149855</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Regulates global gene expression after oxidative stress. Interacts and stabilizes mRNAs and may regulate their transition between different cytoplasmic components after oxidative stress.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with csx1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760195.1">
        <property type="nucleotide sequence ID" value="XM_016905815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QHZ3"/>
    <dbReference type="STRING" id="692275.N1QHZ3"/>
    <dbReference type="GeneID" id="27902952"/>
    <dbReference type="eggNOG" id="KOG0108">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022096_2_0_1"/>
    <dbReference type="OMA" id="GMQRDDS"/>
    <dbReference type="OrthoDB" id="434258at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02639">
        <property type="entry name" value="R3H_RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12253">
        <property type="entry name" value="RRM_PIN4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.50:FF:000002">
        <property type="entry name" value="Immunoglobulin mu DNA-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000183">
        <property type="entry name" value="R3H domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034186">
        <property type="entry name" value="PIN4-like_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034069">
        <property type="entry name" value="R3H_Cip2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="15">
        <location>
            <begin position="162"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="R3H" evidence="16">
        <location>
            <begin position="323"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="248"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="494"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="541"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="270"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="497"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="595"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00062407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMF12074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="621" mass="67877" checksum="FF66643BCFB7CEC6" modified="2013-06-26" version="1">MQHQQYADMYYDHPAGRSPTSVRQSSLHRQNSRQQFEPAYGHLPSGLYTAEDHAQSFNGNPRFNANDMRNATVGGYGNGGYDNMGGQSWNAGAFGQNNTLNGLGGPNLRKPPSRGGRSGLPSAWMDQQQQHMPMNQYGVGGYGGQMGRHDIHSEPDEELIPTAIVIKNIPFAVKKEQLVGIMTEMGLPLPYAFNYHFDNGVFRGLAFANFTNPDETATVIEAMNHFELNGRKLRVEYKKMLPAAERERIEREKRERRGQLEEQHRPMAGATLQTQASASSLSSRMINASSPSPVSARQKIGPAFSELSYTDSATGGPEVNLNDATQLNYYTKLMLFKEDASKDLLVFAPTLSPPERRIVHTLAHHMGLGHASKGDANQRAVHVFKEGRQRLSPPIPALANLQTDQRRQLNRAATTDFSDVRANEGYYAPNNLRHQASGYLGYHDTPNGLNPGGNLRSAKSFADLRSYTPSPVPSTASFPAALSNNVQRLQQDFGRETGQSGTPTLMTPTSGLAERGDASGLINGLGNMTIGSGFAGSPRGLRGFPSWESGNPGPIGSNRSFSNFDDRSQTRSALQGGPERQPRGPLPERGAGFSRRQNGHMQRNSDELSQQSSAAEITVEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1QI82</accession>
    <name>N1QI82_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GA4 desaturase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_112979</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765077.1">
        <property type="nucleotide sequence ID" value="XM_016901009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QI82"/>
    <dbReference type="STRING" id="692275.N1QI82"/>
    <dbReference type="GeneID" id="27898146"/>
    <dbReference type="eggNOG" id="ENOG502RZAA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042688_2_0_1"/>
    <dbReference type="OMA" id="NYVMSHG"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF3">
        <property type="entry name" value="OXIDOREDUCTASE AN1597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF16956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="35591" checksum="1BC6E3DB3F917F0D" modified="2013-06-26" version="1">MVEPLPPTEPQWIGTNHDVWTHINYFPRDIGGMISASAVPPPKRADGRLHSGRMMTVTNISGRESDFQIDRNGFEIVALPPMLRDMTTDALIESRFYPELESVIKSHTGASSVFPLGHVLRRPTNEIFQEKKDTERYNRYGAIFPHCDGPVAVPERLQQLKELAMQSPAVIKNDHAKTVDKAASRWAMIQIWKPLNTVECDPLAICDVLSYQDSDWRLRLTPSPSTGYSVLTHPDGPEMHRWYYVHGMTPEQMFLFKGCDSRQGQPGFTGYAGAHTAITVPDSNEKSFRESIEARFLCFWVEEGEEEADQQSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1QIL5</accession>
    <name>N1QIL5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyltransferase family 15 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_86737</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759781.1">
        <property type="nucleotide sequence ID" value="XM_016910422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QIL5"/>
    <dbReference type="STRING" id="692275.N1QIL5"/>
    <dbReference type="GeneID" id="27907559"/>
    <dbReference type="eggNOG" id="KOG4472">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024327_4_3_1"/>
    <dbReference type="OMA" id="WCFFLYQ"/>
    <dbReference type="OrthoDB" id="439943at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000051">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Ktr4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF7">
        <property type="entry name" value="MANNOSYLTRANSFERASE KTR4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018153">
        <property type="entry name" value="Glyco_trans_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR018153-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF11660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="404" mass="47791" checksum="070C3685772CA087" modified="2013-06-26" version="1">MAIPKPIRLLALATMVLFVFLLVQIMRNPTVARLPEGHAKLEDMVRDPNLDATDEPPEPLHRVSGNNYDADNPHSDRINATILSLVRNSELSQIVGSMQELERTWNHKFNYPWTFFNDEPFTEEFKKATSANTKAECRYELIPKEHWEIPSWINADLMKESAKILEEKNIQYASMKSYHQMCRWNSGLFYKHPALKDVQYYWRVEPHVNFFCDVDYDVFRYMRDHNKTYGFTINIYDSPQSIEQLWPETIKFLAGNNKYLAKDNAMGWLTDKERRPEHNQIANGYSTCHFWSNFEIADMNFWRSEAYEAYFEHLDRAGGFFYERWGDAPVHSIALGLFEEQSRVHWFKDIGYRHIPFFNCPNSPKCKGCQAGKFYDGEPFLQKEDCRPNWFKYVGMGDWKKQDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1QIM5</accession>
    <name>N1QIM5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Swi5-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_133680</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SWI5/SAE3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759791.1">
        <property type="nucleotide sequence ID" value="XM_016902576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QIM5"/>
    <dbReference type="STRING" id="692275.N1QIM5"/>
    <dbReference type="GeneID" id="27899713"/>
    <dbReference type="eggNOG" id="ENOG502SBQH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126161_0_0_1"/>
    <dbReference type="OMA" id="SEMIMAH"/>
    <dbReference type="OrthoDB" id="255837at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032798">
        <property type="term" value="C:Swi5-Sfr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034974">
        <property type="term" value="C:Swi5-Swi2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010772">
        <property type="term" value="P:meiotic DNA recombinase assembly involved in reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000709">
        <property type="term" value="P:meiotic joint molecule formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010760">
        <property type="entry name" value="DNA-repair_Swi5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28529">
        <property type="entry name" value="DNA REPAIR PROTEIN SWI5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28529:SF2">
        <property type="entry name" value="DNA REPAIR PROTEIN SWI5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07061">
        <property type="entry name" value="Swi5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF11670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="167" mass="17980" checksum="1DBEF45E642DBCE8" modified="2013-06-26" version="1">MSSQQQPSPQHPGLSSSFVSSDAPLPSSPTPAKKFIPAEPESISTMNTEVDKNTPPVQNAANPRLAALATKRASLEAKLADLQAQRLRYINNATLPSGLAIPAEWTEEQRAKQALATANGVLKEHITLLHAYNEIKDIGLGLMGLVADQRGVRQKVIMEEFGMGDKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1QIY1</accession>
    <name>N1QIY1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_145538</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764353.1">
        <property type="nucleotide sequence ID" value="XM_016903115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QIY1"/>
    <dbReference type="STRING" id="692275.N1QIY1"/>
    <dbReference type="GeneID" id="27900252"/>
    <dbReference type="eggNOG" id="ENOG502RK98">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1001586_0_0_1"/>
    <dbReference type="OMA" id="WFALNER"/>
    <dbReference type="OrthoDB" id="2115692at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF14">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="105"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF16232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="283" mass="32213" checksum="30EDC986871AAE00" modified="2013-06-26" version="1">MSPFIMEPYRPTPSPPPRRKPRSSSFSVSLAKYDDIRRLVDIEFFAFEKERTNHILSYRDYRQPAHLERAVRSYQSAISGSDANRRRRKSASARRLDRRSNGDVVRFRKVTDRETGLIISWAKTETKAYTQDELASPADSGHENEALMNRDWFALNEKLKRDYMGTQKHCYISMLATQPTYQHHGAGTMLLEDILTEADEAGVECYLEATDTAKPLYERHGFEMVNELRFDPSAYGVCGFSVERQTIMVRGALDRVSGQRKQVRSWAEATGGPGSPTSESDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJ60</accession>
    <name>N1QJ60_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SPT2-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_146316</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SPT2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765346.1">
        <property type="nucleotide sequence ID" value="XM_016903574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJ60"/>
    <dbReference type="STRING" id="692275.N1QJ60"/>
    <dbReference type="GeneID" id="27900711"/>
    <dbReference type="eggNOG" id="ENOG502QRJX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_769420_0_0_1"/>
    <dbReference type="OMA" id="PQIAYKG"/>
    <dbReference type="OrthoDB" id="5430658at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013256">
        <property type="entry name" value="Chromatin_SPT2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08243">
        <property type="entry name" value="SPT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00784">
        <property type="entry name" value="SPT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="325"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="136"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="326"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF17225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="364" mass="38393" checksum="895CFDE55A409A7E" modified="2013-06-26" version="1">MTSFTSLLGSIGGPKQNQAPAQNASAGASASASRAVQKPDATTSTPSISRPNANSHVAAGTKRKPEEQITAPPAKAMRVDVKTPVPPSGLSRVAQRGTLVSPSTHTPPRGTTKPGPAKDNPKANESLKSRTVLQRPAPSTPATTAATTPGGSVAKPKRGFASIMEKAKAAQEAAKAAGSSTIKHKPVEKLTKKERLKLEEEAKLKTGPKTSKALAGRSRSGTPADGRCSSNKNEPEAGYKGTMKKTPVQPQIAYKGTMKKSEPGAPPGKAAVKKGLGQDKYGGYASWSDLDDAEEDEDGYGSEGSDDMDAGFDDMALEEEMALRAARKEDQEALEEEERHKREKLERKKKLEALSKSAAARKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJ66</accession>
    <name>N1QJ66_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Aromatic compound dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_67147</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the intradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759951.1">
        <property type="nucleotide sequence ID" value="XM_016909777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJ66"/>
    <dbReference type="STRING" id="692275.N1QJ66"/>
    <dbReference type="GeneID" id="27906914"/>
    <dbReference type="eggNOG" id="ENOG502SMA8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046727_1_1_1"/>
    <dbReference type="OMA" id="FYCYHPT"/>
    <dbReference type="OrthoDB" id="5238185at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018576">
        <property type="term" value="F:catechol 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009712">
        <property type="term" value="P:catechol-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007535">
        <property type="entry name" value="Catechol_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050770">
        <property type="entry name" value="Intradiol_RC_Dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711">
        <property type="entry name" value="DIOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711:SF5">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASE PRCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04444">
        <property type="entry name" value="Dioxygenase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catechol dioxygenase N-terminal" evidence="9">
        <location>
            <begin position="43"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Intradiol ring-cleavage dioxygenases" evidence="8">
        <location>
            <begin position="129"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF11830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="334" mass="37310" checksum="9DB1A7BF9185C651" modified="2013-06-26" version="1">MSDYQQPTANGPKTDASASASGRQYDPNFTKHVIDTCGPKTSPRMKLIFSALTRHIHDFAREVDLTPEEWLAGVKFLNETGKVWAESGGKRNEMHRLSDIIGLESLVTEIANYVQIDDPNYVPTSAAILGPFWSPNAPWRELGGSIIQDEPKDGVVTYMHGIIRDMKTKKPMPGVTFDMWQASSNGKYDFQDPDNQSDNNLRGKFKTDENGEYRLYCLRPTAYSLPQDGPAWDLLTAIDRHPMRPAHIHLMITKEGYKPCITQIYPKDDPWLETDTVFAVKDDLVVDFVPLKELPANMPPNAGKGGPATRELELDIVLAPLGSMLNNAEPVVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJ91</accession>
    <name>N1QJ91_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Ferric_reduct-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SEPMUDRAFT_153297</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765422.1">
        <property type="nucleotide sequence ID" value="XM_016907507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJ91"/>
    <dbReference type="STRING" id="692275.N1QJ91"/>
    <dbReference type="GeneID" id="27904644"/>
    <dbReference type="eggNOG" id="KOG0039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019268_1_0_1"/>
    <dbReference type="OMA" id="GREVWWH"/>
    <dbReference type="OrthoDB" id="10006946at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="13">
        <location>
            <begin position="282"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="482"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="483"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMF17301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="610" mass="67810" checksum="8F0E7F1A13D3F5E9" modified="2013-06-26" version="1">MYHFVDLSREQRLDRRHLLDFYGLVAQFSVLVPVAGVILAYLASKCLLYLNNNKSTPESPSSPRIKAARRFWDFSSIQSRWRRVLWWSTTPVHIWGFLLGTRGEILGAIAWTGWLLALSVLDTGEDYLHLTKRLGTIGASQLPFHYLLSLKSPWSPLLLLTGYSEATLLSIHKALGRIITGFFWLHAILYLNFYVFKSLLLEKLQESYVLCGVFGILAFSIVTTTSLSVLRTWSYRVFYYTHVSLASILLPVLYFHVEHIRPFIYETAAIYAINVLLRYFASTTYMGTMQRVEGGRGSSSNLIEISIPLGKGGGGGGAAAAMKWQPGQHAYISLAGHPFLRTFRSNPFTQASLPLVDNRLRFIARIMDGNTARLARSIRDDALSFSVEGPYGIGTHSATLLRYDRVLFVAGGVGATFVVPLYRQLLADLSPSKGSYRRQKVRFVWVARSLADVTWALPVESKERDGFVERLSVHVSRQTADITTTSSTTTGTSTTATTSQAPDSGAFVIDSDADDGPEEEGIELDEQKELLQGQGNSANTSTEFSCNMEVSSGRPNVVRVVDQVFSHGGTESVAIVACGPRSLSHQLRKSVSPWAQKGRDVWFWDESFAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJR7</accession>
    <name>N1QJR7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">3-HAO-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_150792</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758915.1">
        <property type="nucleotide sequence ID" value="XM_016906399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJR7"/>
    <dbReference type="STRING" id="692275.N1QJR7"/>
    <dbReference type="GeneID" id="27903536"/>
    <dbReference type="eggNOG" id="KOG3995">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095765_1_0_1"/>
    <dbReference type="OMA" id="FYQHKGG"/>
    <dbReference type="OrthoDB" id="204928at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000334">
        <property type="term" value="F:3-hydroxyanthranilate 3,4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046874">
        <property type="term" value="P:quinolinate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06123">
        <property type="entry name" value="cupin_HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010329">
        <property type="entry name" value="3hydroanth_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03037">
        <property type="entry name" value="anthran_nbaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15497">
        <property type="entry name" value="3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15497:SF1">
        <property type="entry name" value="3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06052">
        <property type="entry name" value="3-HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF10794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="155" mass="17535" checksum="D3CFB445B2444E0C" modified="2013-06-26" version="1">MTIMIVGGPNARTDYHINSTPEFFYQYKGRMLLKTIQQDVNGKDTFQDIYINEGDMFLLPGNTPHNPVRFADTVGVVIEQPRPEGSLDRLRWYCQSCGNQVHEASFHCVDLGSQIKDAVNAFKEDEKARICERCGEVCDTAPKEAVMEQMRTAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJT3</accession>
    <name>N1QJT3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 subunit A</fullName>
            <shortName evidence="7">eIF3a</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 110 kDa subunit homolog</fullName>
            <shortName evidence="7">eIF3 p110</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Translation initiation factor eIF3, p110 subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TIF32</name>
        <name evidence="10" type="ORF">SEPMUDRAFT_145772</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the eIF-3 subunit A family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764663.1">
        <property type="nucleotide sequence ID" value="XM_016903256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJT3"/>
    <dbReference type="STRING" id="692275.N1QJT3"/>
    <dbReference type="GeneID" id="27900393"/>
    <dbReference type="eggNOG" id="KOG2072">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002096_2_1_1"/>
    <dbReference type="OMA" id="EHITNKR"/>
    <dbReference type="OrthoDB" id="18884at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043614">
        <property type="term" value="C:multi-eIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002188">
        <property type="term" value="P:translation reinitiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.860:FF:000003">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.10:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.860">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.10">
        <property type="entry name" value="UVR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03000">
        <property type="entry name" value="eIF3a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027512">
        <property type="entry name" value="EIF3A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054711">
        <property type="entry name" value="eIF3a_PCI_TPR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14005:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14005">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3, THETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22591">
        <property type="entry name" value="eIF3a_PCI_TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PCI" evidence="9">
        <location>
            <begin position="347"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="630"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="808"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="652"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="808"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="870"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="922"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1015"/>
            <end position="1056"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF16542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1083" mass="122728" checksum="758D132698286E5A" modified="2013-06-26" version="1">MPPPPHTRPENVLKRAQELIGVDQKQAALSILHEHVTSKRTRNSTIAALEPVMLLFVELCVELRKGKSAKDGLYNYKNTSQNTNVATIELVFRRFIELAEQKVTEAQAKADEISQSTASGEGEGETTDATLANVTDLEAMETPESILLSTVSGEQSKDRTDRAIVTPWLKFLWETYRTVLDIFKNNARLEVMYQTTAHQAFQFCLKYTRKTEFRRLCELLRNHLQNAAKYSQQVHAINLSDPETLQRHLDTRFMQLNVAVELELWQEAFKSVEDIHTLLSLSKRQPKNSMMANYYEKLTRIFLVSENYLFHAASWSRYYNLLNLSARQVAAGASKKDNPSNITDNDLSKAASFVLLSALSIPVISTSRSRGALIDVDAARNTKNARLTNLLGMNSPPSRAILFKDALNKDILQRARPEIRELYNILETDFHPKSICEKVSPILSQIGADEEMKRYVLPLQQVILTRLFQQLSQVYTDVKLEDVTALAQFPDPFQVSTATIEKFIMNGCKKGDLSIRIDHSTGILTFDSDVFSSAKAMHPGSGAGSAEADASSVQRLQSTPAEIVRSQLSRLSKALYIAAQYVDPTFNEQRQKARLAALQRAEAGAEKEHVELLARRDLIQKKKETAANVQLARQREEEQKRRVRQQELQAAETERLAQETRDREERRLQAERKKVQREEAEKQLQELKKGVKGVDLSELDIDNLDTGKIRMLKLQALEKEKNEIGDKVRIAGKRIDHLERAYRKEEIKHLGRDYEMQREQDFKAWEDSKNETLNTAKEKHKQDVALKHRLSRLVSPYEQFKRAITEQRQAEFDKRRKAADRELNDAKEKRRREVRDAKAAEKRRAEEEERAQREAEERARIEEEEAAAAAEEKRRKDAEAKAEAEQRRQERMEAARKQMEREEEAERKRLERKQGGAAAAKPFERTTFERRAEPASEPSTSSGPPRLALAGSKPTWREREAAKAAQGGTPPVEAPAPAVDSVPTDEAAQPARSGYIPPALRGKAPGADSAPPAEGKPERWQARSRGAEGERSDTPERKPATERWAPRRANEPERSETPPAPTGGTYKPPGQRSGGTYRPPGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJX6</accession>
    <name>N1QJX6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3074 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_145801</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764703.1">
        <property type="nucleotide sequence ID" value="XM_016903278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJX6"/>
    <dbReference type="GeneID" id="27900415"/>
    <dbReference type="eggNOG" id="ENOG502S6FW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022947_0_0_1"/>
    <dbReference type="OMA" id="MNPVEWI"/>
    <dbReference type="OrthoDB" id="5403181at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024500">
        <property type="entry name" value="DUF3074"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40370:SF1">
        <property type="entry name" value="DUF3074 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40370">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11274">
        <property type="entry name" value="DUF3074"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3074" evidence="2">
        <location>
            <begin position="120"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="297"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="658"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="401"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="461"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="670"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF16582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="683" mass="74770" checksum="A59D1C1F00C0A8E9" modified="2013-06-26" version="1">MKELHEALTYLGPVDWNEVPTDDLKQFASACLTAGELIINSVPPNPDGTPFNASKASQSKPNQATSHQGVTASEARSDPPHEDHVRLQKSWGKPYKFKKEQNPHNVALYKMAGNDRHGAWFARRSVHEGIGYDRFKRAMMREFSQALTVQGEPGAGAVRGIAADRRLERIDIPGLGKLEVYELSAAFPGPVTPRDFVALVISSDSTLSDKSAVDIGGNTHVPRHFMVLSKPVAHPDAPSRSGLVRGQYESVEVIREIPLSTAKSTSTTKLVRTNSNDTQSKGTQGRDANASDEPELNPVEWIMVTRSDPGGGIPRFLVERGTPEAMLGDLTKFFDWACALDEIPHPDDDLDEQRGVPGEQAEKTKTGGTSSAPSEVNGSAPVSSETPTTASNPVLPERTKPAPAAAYSTTTTTHESSQGGYLSGFTNAIEAGIEAYAPASVSGVLLQHLHPEPESSDDSSDTSSMESFLSAEELRRVSTAPEVQAPDVSTDNLSIMSGNVSEEAKNIKGMSHHEKEVLKLVRKREKLDQQLAKKRLAEQQKIKEAQEKDNSESGKTQEKIEQQLKKTEEKHRREVEKLEAKKAKEERKAEEKRKKKDDRYKLSLVSRERDDFRSQADLLRRENSLLRNQVADLQTQNTLMAQKLGALGGREALKEIDEACGRSRSTSIKSTEALSSSTATTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJZ4</accession>
    <name>N1QJZ4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">CDP-OH_P_transf-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_149892</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016905836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJZ4"/>
    <dbReference type="STRING" id="692275.N1QJZ4"/>
    <dbReference type="GeneID" id="27902973"/>
    <dbReference type="eggNOG" id="KOG1617">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051314_0_0_1"/>
    <dbReference type="OMA" id="DHHTWAL"/>
    <dbReference type="OrthoDB" id="10020554at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043337">
        <property type="term" value="F:cardiolipin synthase (CMP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Phosphatidyl synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF60">
        <property type="entry name" value="CARDIOLIPIN SYNTHASE (CMP-FORMING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="51"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF12130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="407" mass="43582" checksum="873D00F646337C50" modified="2013-06-26" version="1">MMAKLLPRRLHVLGLPQHVRSSAVAPAFATCAPGPSSFLWPHQGRSLGFVSSAAGRTGSSPSSSPFRASTSVSVKWPRPYSQSSKATQPLDRQEGVDQSSSKPAQPAAATPKQPITKSFEAARERTQAVRAKVRSSLTGLTPHENIYNLPNFLTLTRLVAAPATAYLVLHDQHTLALGLFAYAGITDLIDGWMARKWKLQTVAGSVMDPMADKALMIIVTVTLAVKGAIPLYLATLVLGRDASLALAALYYRYASLPAPKTFLRYWDFSLPSAEVHPTTVSKYNTFLQLILIGSTLALPVITAGGQGTDLLQSFGLSTGQLHNALTYFQWLVAATTAWSGLSYAYLKNAVTILGPNETLKAKQGARGRAIIGLTFGSCVLAAVWLATTVDAPVQPESPRRENSIPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1QK97</accession>
    <name>N1QK97_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ARM_1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_76111</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764798.1">
        <property type="nucleotide sequence ID" value="XM_016910124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QK97"/>
    <dbReference type="STRING" id="692275.N1QK97"/>
    <dbReference type="GeneID" id="27907261"/>
    <dbReference type="eggNOG" id="KOG3037">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041798_4_0_1"/>
    <dbReference type="OMA" id="RSPQFMQ"/>
    <dbReference type="OrthoDB" id="340431at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061133">
        <property type="term" value="F:endopeptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13314">
        <property type="entry name" value="PH_Rpn13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2020.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.70">
        <property type="entry name" value="Proteasomal ubiquitin receptor Rpn13/ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006773">
        <property type="entry name" value="Rpn13/ADRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044868">
        <property type="entry name" value="Rpn13/ADRM1_Pru"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038633">
        <property type="entry name" value="Rpn13/ADRM1_Pru_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038108">
        <property type="entry name" value="RPN13_DEUBAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225">
        <property type="entry name" value="ADHESION REGULATING MOLECULE 1 110 KDA CELL MEMBRANE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225:SF0">
        <property type="entry name" value="PROTEASOMAL UBIQUITIN RECEPTOR ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04683">
        <property type="entry name" value="Rpn13_ADRM1_Pru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51917">
        <property type="entry name" value="PRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pru" evidence="7">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="169"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="184"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF16677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="388" mass="41386" checksum="4311A8B6560DBFEE" modified="2013-06-26" version="1">MAATPIITFKAGLCKFTDRTVTPDPRPGYIYLYSEDELMHFCWRPRSAPSTEPEIDLIMFPTDGHFYPYVKEQGAEELHSPTNGRIFVLKFSSSNQRHYWWMQSKTQSREGEHSWFSERDQRIGQVIDQLLQGEDVDVTAEIDHIRGGGNAGTDGDADAMEVDQDRSLARQGSGGAGQDAGNGDPREEGEASREGGADGGRADSSSSSAPQQDANTAVQNFLQSLNSGGGSLGGPQQAVEKPFTSLPDLLSTSTTTAYISDASPAEIDNLCSFLPPELFLLAQESTSSTSAAEPTPSTTQAALETLSIGQKKEILNKVVRSPQLQQSLGSLTIALRDGGLPMIGEALGIKIANGGNIKGGSMPLGGSAAVEAFIDGVKKTAEEQAKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKQ8</accession>
    <name>N1QKQ8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC_membrane_2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_146726</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765891.1">
        <property type="nucleotide sequence ID" value="XM_016903824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QKQ8"/>
    <dbReference type="STRING" id="692275.N1QKQ8"/>
    <dbReference type="GeneID" id="27900961"/>
    <dbReference type="eggNOG" id="KOG0064">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007587_5_0_1"/>
    <dbReference type="OMA" id="DIQAGHF"/>
    <dbReference type="OrthoDB" id="422637at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF69">
        <property type="entry name" value="PEROXISOMAL LONG-CHAIN FATTY ACID IMPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="117"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="462"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF17770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="734" mass="82378" checksum="F8D1C6F2D7359640" modified="2013-06-26" version="1">MAVQSLPLTVSTRGLKQILSDLTSLYVAHRTKISRSIYAALLLAVIQRIRGAIKEQKAAAARAADHRRKGLGGDDSGKKKKKVELDREFFRSLGRLLRICIPSWRSKEARLLASHSIFLVLRTLISLYVSYLDGRLVSDLVRGRGKAFLKGLVWWMLVAVPATFTNSMLAYHQTTLSLSYRARLTNYIHNLYLGNMTFYTLSALDDRIKNADQLITVDVTKFSNSLAELYSSLSKPTLDLVIYNWSLSRSVGGEGLFAMSLMVQLSASLMRALTPPFGRYVAEEAKLEGEFRAQHSRLIDYSEEIALYDGHDAEKDTVDKGYFTLIRHVNRILRRRLYHGIMEEFVVKYFWGALGLLLCSVPVFFKLPGALPGSHGTGDKTEAFITNRRLLLQSSDAFGRLMFSYKEISELAGYTSRVSMLLDVIADIQRGHFEKALVSSASTEANAAILAGRGELEEGDDIKFQDVPIVSPNGDILVRALSFHIQQGDHMLIVGPNGCGKSSLFRILGGLWPVYGGRVRKPTNEDIFYVPQRPYLSKGTLRQQILYPDNLLDMRAKGVTDQDLIHIMKKLGLESLLSNSGAQYAVNAGEGNSPIETRGRPHVDAAGLNVEQEWPEALSTGFQQRIAAARLFYHRPKYAILDECTSSLTPELEKIMYDEAKALGITLMTVSHRRSLWRYHGWILQFDGQGGHVFTRLDAEKRLELEDEKEELDLQLRAVPEWEKRIAELEAGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKS7</accession>
    <name>N1QKS7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_146783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765987.1">
        <property type="nucleotide sequence ID" value="XM_016903861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QKS7"/>
    <dbReference type="GeneID" id="27900998"/>
    <dbReference type="eggNOG" id="ENOG502RWG2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124588_0_0_1"/>
    <dbReference type="OMA" id="ANSDVEC"/>
    <dbReference type="OrthoDB" id="3942467at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF17866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="187" mass="19943" checksum="1C66923BBF66E0D1" modified="2013-06-26" version="1">MDSITHVTNKMLAELARQQQQQTPPESAPPPYTATDEDSESDDDLDDMDDEEDDSSIPMKLTVNAAHNIQGCNNLVPTSPHPLADATKFSTLLLHAVNQINAANAAANSDVECSSKRRRPLKIELTVNCGITVVGDRNVIGPVAMKPRDTLASTSSSSAVAGAKRKADEPPVGEDEPATKKVAVDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKW8</accession>
    <name>N1QKW8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">homogentisate 1,2-dioxygenase</fullName>
            <ecNumber evidence="4">1.13.11.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SEPMUDRAFT_146823</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the homogentisate dioxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.5" evidence="4"/>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_016903888.1"/>
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    <dbReference type="STRING" id="692275.N1QKW8"/>
    <dbReference type="GeneID" id="27901025"/>
    <dbReference type="eggNOG" id="KOG1417">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OMA" id="MLPHGPD"/>
    <dbReference type="OrthoDB" id="1689029at2759"/>
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        <property type="reaction ID" value="UER00339"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004411">
        <property type="term" value="F:homogentisate 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07000">
        <property type="entry name" value="cupin_HGO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000053">
        <property type="entry name" value="Homogentisate 1,2-dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046451">
        <property type="entry name" value="HgmA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046452">
        <property type="entry name" value="HgmA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005708">
        <property type="entry name" value="Homogentis_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01015">
        <property type="entry name" value="hmgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056:SF0">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04209">
        <property type="entry name" value="HgmA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20510">
        <property type="entry name" value="HgmA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase N-terminal" evidence="15">
        <location>
            <begin position="13"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase C-terminal" evidence="14">
        <location>
            <begin position="289"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="448"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="456"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007757"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00013127"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR605708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605708-2"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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            <dbReference type="Pfam" id="PF04209"/>
        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF20510"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMF17911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="470" mass="52266" checksum="F7FE3FF7D7A1D004" modified="2013-06-26" version="1">MPVTQFSLPEKYKYQNGFGCYHETEAVEGALPVGANNPQKPPYGLYNEKLSGTAFTAPRHENKQTWLYRILPASAHSNFEPRESSSYDLNPGGLRDAKWHQIPNQLRWDPFDLDETVDWVHSLKLVAGAGDPTMKSGLGILIYAAGKDMDEKHAFYTADGDLLIVPQHGALDIQTELGRLLVRPNEIAVIPRGIRHRITLPEGPVRGYVLELYQGHFELPELGPIGSNGLANARDFQAPVAAFDEDTESEYTLFAKFSGTLFAAKQNHTPFDVVAWHGNYYPYKYDLGRFNTIGSISYDHPDPSIFTVLTAQSDHAGTAIADFVIFPPRWLVAEDTFRPPWYHRNTMSEFMGLIHGQYDAKTGGGFQPAGASLHNVMSAHGPDASTHEKASNLELKPAKVGDNSMAFMFESCLMVGVTEWGLKQCQKVQDNYNAESWEPLKAHFNRKASVPKPDANGSQEANQQALPHYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKX6</accession>
    <name>N1QKX6_SPHMS</name>
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        <submittedName>
            <fullName evidence="9">ADP-ribosylation factor 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_58681</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the small GTPase superfamily. Arf family.</text>
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    </dbReference>
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        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
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        <property type="entry name" value="Small_GTPase_ARF"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="SAR1GTPBP"/>
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        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="3 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF17850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="184" mass="20895" checksum="1CFBEE39E465BAA1" modified="2013-06-26" version="1">MGQKISKIMNQIFGSKEMRLLMLGLDAAGKTTILYKLKLDTDVTTIPTVGFNVETVTYKNTKFNVWDVGGQDKIRPLWRHYFSGTQGLIFVIDSNDRDRMEEARSELARIIQDREMKDALLLVFANKQDIPGAMRPKEVSDMLDLQRIARDHTWKVEPSCATTGEGIFEGLAWLSSNVKLPSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1QLT7</accession>
    <name>N1QLT7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Arginase/deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_145939</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the arginase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764899.1">
        <property type="nucleotide sequence ID" value="XM_016903354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QLT7"/>
    <dbReference type="STRING" id="692275.N1QLT7"/>
    <dbReference type="GeneID" id="27900491"/>
    <dbReference type="eggNOG" id="KOG2964">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039478_1_0_1"/>
    <dbReference type="OMA" id="RNDIRCG"/>
    <dbReference type="OrthoDB" id="288726at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008783">
        <property type="term" value="F:agmatinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033389">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via agmatine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11592">
        <property type="entry name" value="Agmatinase_PAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="ARGINASE/AGMATINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358:SF28">
        <property type="entry name" value="HYPOTHETICAL ARGINASE FAMILY PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR036979-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF16778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="366" mass="39643" checksum="F98288EFCF4377D8" modified="2013-06-26" version="1">MMPGLDDEDISQTKFAGLTTFANLPYVHCLAADDDEEEEEDEDKKKKKKKKKSVGVEKFDIAILGAPFDTGVTARPGARFGPLGIRQGSRRIAPDFSWSVYTGQNPFKQGLKIVDCGDAPLTVLDNTIALRQLERAHKVVSARRTNSTEFTVPRIITLGGDHTTTLPALRSTFTHFGAVSVIHFDSHLDTWDPDVLGGGLSHYAGVNHGTFLHIAHEEGLIRNSSIHAGIRAPVSNPKYDLKNDRACGFHILTARDLDKLGTTNFIQHLKDRVQGSPVYITVDIDSLDPAYAPATGTAEPGGWSTRELLTILDGLSGLDVIGADVVEVAPIYDNPGEVTTLAAAEVVRSLIELMVVKPVKAIGSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1QLY3</accession>
    <name>N1QLY3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_122663</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765368.1">
        <property type="nucleotide sequence ID" value="XM_016901790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QLY3"/>
    <dbReference type="STRING" id="692275.N1QLY3"/>
    <dbReference type="GeneID" id="27898927"/>
    <dbReference type="eggNOG" id="ENOG502SAE9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_756871_0_0_1"/>
    <dbReference type="OrthoDB" id="5350396at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF17247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="366" mass="40536" checksum="AACBB292D32D1535" modified="2013-06-26" version="1">MAVTNWMAQQLLHERNDALCEAYVGILEASSSHNESLSDTIASLSSMYKTRSLFENNWKAPVRRGLPAGLKYVLRVVQSRAPAVDDVAPDAAPIKTIEAFLDLAMMNLDDLVRKNHNLSSTLMKCIEDLLDSLSETSFEKLVPGVLAVLDDSERELPIQLHCRLIASLPARTTRSYHLRRRLALDVLLPKDERRKAESSERNWLETILKALESGQQFNIGDATDYALLMALINVADIAVSAGFTGYDALHPSQASSEKSSLSIYAGPPPVSQAAKIHNRQIDAIVSELEYMKSIIQHESTSLCRQELKAALERVTARLGTSVRTRPKPKKQIFGTERKQAHFATNMLKIAPNALDRSGAEETESMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1QM67</accession>
    <name>N1QM67_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_145685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764560.1">
        <property type="nucleotide sequence ID" value="XM_016903201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QM67"/>
    <dbReference type="STRING" id="692275.N1QM67"/>
    <dbReference type="GeneID" id="27900338"/>
    <dbReference type="eggNOG" id="ENOG502S0DI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028621_0_0_1"/>
    <dbReference type="OMA" id="KVVFRWK"/>
    <dbReference type="OrthoDB" id="3357341at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="318"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="459"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF16439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="538" mass="59279" checksum="D6AC53CFB68FE1EA" modified="2013-06-26" version="1">MLDENLPCFYLKQAAADGIKHHRDIHHSHNGSNPAPAYSLHNADPASLQPAYRNCYGAALFDAYNPDVLFGEVVVRPDWTQPTLNQEEIRRNGGIAPPPQPVLPHDFAIQLYNPDQQVKVDVKEGKWGASDSYEFSLPSVAFRTPSASHLDRGQSDPAMLPVTPKINFVWRKESKLSKDLTCYMTGKSTDLDSKKKSKRDPDIAVALWRSLRELTIYESNLDRLELEDPKGVEVVLLLSAIAIRDLWFVAHKDGLREAFNISGLPNERKLSGGGKKLSSSCRVVNALSIVGAPALSHHPPSVHAAQGGRTPSQPQSMANNPSSNPHPPTTASNSKPPPHVDPRSAWELDAETARLKAQAEAEAKAERRRQKEKARADEAERQRLQRMVAEEERVRRIREAEVEKETERLRKIYGVPQQQQQQANIARPHTSMAMGRPQNQRVNNSAAGAPPPQPPRQPSRPQQGQGSSGMYRQPGANASMMMMSGANGNASSLNLGQQQAMKKKKSSFFGLRGGCGTVDQSTTAHGGGRLMKKNSAMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1QMI0</accession>
    <name>N1QMI0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_77933</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765673.1">
        <property type="nucleotide sequence ID" value="XM_016910180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QMI0"/>
    <dbReference type="STRING" id="692275.N1QMI0"/>
    <dbReference type="GeneID" id="27907317"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053582_0_0_1"/>
    <dbReference type="OMA" id="QSTTHHI"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001102">
        <property type="entry name" value="Transcription factor IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000060">
        <property type="entry name" value="zinc finger protein 436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="283"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="152"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="113"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="157"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF17552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="321" mass="34661" checksum="764C75CD53C7B6F7" modified="2013-06-26" version="1">MQPQTHPYNHVQPRSPQPSGSPTSDDGFKPSLPSISNLLSFADRPATDRTAQSPQASSTQQQRDPAESQPASPRSTHSAVVQSVPAGVFPAAEATSSPRDAIPPQPVMRTESVVDSTNSPSAMSTMSGSPYFVGNTISTVDSTDQRNAHLHEIKRSSVPSQPHGSPYANSRYTSSPYADSSSTMPAPTYYSPQPGTYSIPQGLYQQRPLPSNFPPAPPEAQVQSSIALPTSNPWEHHHYISPSSSATFPQSQDRYICTTCNKAFSRPSSLKIHSHSHTGEKPFRCPHNGCGKAFSVRSNMKRHERGCHSGMTGHVAHAHMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>N1QN83</accession>
    <name>N1QN83_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">P-type Na(+) transporter</fullName>
            <ecNumber evidence="20">7.2.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">SEPMUDRAFT_146561</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26 27">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>K(+)(in) + ATP + H2O = K(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75815"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>Na(+)(in) + ATP + H2O = Na(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:14634"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IID subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.3" evidence="20"/>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765699.1">
        <property type="nucleotide sequence ID" value="XM_016903731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QN83"/>
    <dbReference type="STRING" id="692275.N1QN83"/>
    <dbReference type="GeneID" id="27900868"/>
    <dbReference type="eggNOG" id="KOG0202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_3_0_1"/>
    <dbReference type="OMA" id="PVQKDCD"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008554">
        <property type="term" value="F:P-type sodium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02086">
        <property type="entry name" value="P-type_ATPase_Na_ENA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000160">
        <property type="entry name" value="Sarcoplasmic/endoplasmic reticulum calcium ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000015">
        <property type="entry name" value="Sodium ion P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000020">
        <property type="entry name" value="Sodium ion P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000039">
        <property type="entry name" value="Sodium P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000047">
        <property type="entry name" value="Sodium P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006414">
        <property type="entry name" value="P-type_ATPase_IID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01523">
        <property type="entry name" value="ATPase-IID_K-Na"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0915">Sodium</keyword>
    <keyword evidence="18" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="13" id="KW-1278">Translocase</keyword>
    <keyword evidence="7 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 24" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="326"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="789"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="816"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="867"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="913"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="965"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="996"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="25">
        <location>
            <begin position="23"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00035017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00035029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="EMF17578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1061" mass="116526" checksum="122C88E404CBEDF9" modified="2013-06-26" version="1">MGKSQNPLEGHVSGQSNKPLSQPAHSLKWKEVAEELKADVDDGLTGSEASSRLEEYGKNELGEGEGVNPGKILVRQVANAMTLVLIIAMAVSFAIQSYIEGGVIAGVIFINIAVGFTQEFQAEKTMDSLRSLSSPTAQAVRDGASKSLPTIEIVPGDLVELKTGDTIPADIRLIEAVNFETDEALLTGESLPVRKAHNDVFDAETGPGDRLNVAYSSSTVTKGRATGIVFATGMHTEIGSIAAALRKKDSRRRPVKRNEDGTTKTYRYVQAAILTCTDAVGHFLGVNVGTPLQKKLSRLAVLLFLIAVLCAIIVLGANSFRNQREIIIYAVATGLSMIPASLVVVLTITMAAGTKRMVERNVIVRNLRSLEALGAVTDICSDKTGTLTQGKMVAKKAWIPATGTYTIDQSEEPFNPTKGDISHNEKEPHKVAYNDKDKRTSYAELLQNNDALKDYLRAASLANLATVHQTDSGEWHARGDPTEIAIQVFASRFQWNRRASVSGDNPAMKLLVEFPFDSDVKKMSVIYRDLHSDKMYAFTKGAVERVIASCTSYIPENDKPAVEMTEAYREQILENMEALAKHGLRVLALASRDYTDPYEEGKEIDRATVEKDLIFRGLIGLYDPPRAESAPSVRRCHEAGIEVHMLTGDHPGTARAIAAQVGILPTKMRELSKDVADAMVMTASQFDALSDDQIDALPVLPLVIARCAPNTKVRMIEALHRRKKFCAMTGDGVNDSPSLKRADVGIAMGQAGSDVAKDASDIILTDDNFASILAAVEEGRRTFDNIQKFVLHLLAQNVAQAIVLLVGLVFKDAEDLSVYPISPIEILWIIMVTSGIPDMGLGFQEAAPDVLQRPPQSLKRGIFSWELMIDMVVLGIWIAALTLGAFVLVLYGWGSGTIGIGCNQDIDDGCGLIFRARATAFACLTWFSLFLAWEVIDMRRSFFRMQPNSDRYFTQWMLDVWRNKFLCWAVVAGFVLIFPLLYIPGLNDQVFRHTGISWEWGIVFIASGLFFLGVEGWKWAKRVYFRRLAKKNAVGNVDLETRVFERYLTQSSSISAEKELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNH2</accession>
    <name>N1QNH2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_122687</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765405.1">
        <property type="nucleotide sequence ID" value="XM_016901792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNH2"/>
    <dbReference type="GeneID" id="27898929"/>
    <dbReference type="eggNOG" id="ENOG502RHCF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2051108_0_0_1"/>
    <dbReference type="OrthoDB" id="446723at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF17284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="120" mass="12857" checksum="047E87855DA9A48D" modified="2013-06-26" version="1">MSSAISPILPAITKLQILDALICAAFELHSGGRAVLEFAKVLFGNVPVANAVEEREEDEKNVGMNGHWGESGACTALARAYFLLIEHGEDANAEEVKKIAMSRFIKAGFEAQVAKIREGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M3AS61</accession>
    <name>M3AS61_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cobalamin-independent methionine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Methionine synthase, vitamin-B12 independent isozyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SEPMUDRAFT_152039</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the vitamin-B12 independent methionine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.14" evidence="4"/>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756470.1">
        <property type="nucleotide sequence ID" value="XM_016907206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AS61"/>
    <dbReference type="STRING" id="692275.M3AS61"/>
    <dbReference type="GeneID" id="27904343"/>
    <dbReference type="eggNOG" id="KOG2263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013175_0_0_1"/>
    <dbReference type="OMA" id="KVMKGML"/>
    <dbReference type="OrthoDB" id="1053771at2759"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00082"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019280">
        <property type="term" value="P:L-methionine biosynthetic process from L-homoserine via O-acetyl-L-homoserine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03312">
        <property type="entry name" value="CIMS_N_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.210:FF:000002">
        <property type="entry name" value="5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.210:FF:000003">
        <property type="entry name" value="5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00172">
        <property type="entry name" value="Meth_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013215">
        <property type="entry name" value="Cbl-indep_Met_Synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006276">
        <property type="entry name" value="Cobalamin-indep_Met_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01371">
        <property type="entry name" value="met_syn_B12ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003556">
        <property type="entry name" value="PRK05222.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30519">
        <property type="entry name" value="5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08267">
        <property type="entry name" value="Meth_synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000382">
        <property type="entry name" value="MeTrfase_B12_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE N-terminal" evidence="17">
        <location>
            <begin position="4"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE C-terminal/archaeal" evidence="16">
        <location>
            <begin position="439"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="708"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="444"/>
            <end position="446"/>
        </location>
        <ligand>
            <name>L-homocysteine</name>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="444"/>
            <end position="446"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="497"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="528"/>
            <end position="529"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="574"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="612"/>
        </location>
        <ligand>
            <name>L-homocysteine</name>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="612"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="655"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="657"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="666"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="679"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="740"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMF08349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="770" mass="86990" checksum="2A8BB9CA2AEA757B" modified="2013-05-01" version="1">MVQSSVLGFPRMGRLRDLKKANEAYWADKLSRDELLAEGKRLRLEHWKIQKDAGVDIIPSNDFAYYDHVLDHIQMFGAVPERYSSAKLHKLDEYFAMGRGHQKDNVDVPSLEMVKWFDSNYHYVKPTLQDNQTFTLSENPKPVVEFLEAKEAGINTRPVILGPVSFLALGKADRGSSVDPITLLDKLLPVYEQLLTQLKEAGAETVQIDEPVLVFDLPSKTRSAFKPAYEKLTALQGSKGPQLVLATYFGDVVHNFEVIDSALTGTYAFHVDLVRHPEQLSKVIEHLGPKQILSAGVVDGRNIWKTNFKKAIEVVETAVQKLGKERVIVATSSSLLHTPHTLASEKNLDEEVRAWFSFASEKAVEVAIIAKAVTNGPESVKAELEANAKDAQSRATSKRTNNPEVKKRVEAVKKEDYERKSGFDARYAAQKKHLQLPMFPTTTIGSFPQTKDIRIQRNKFTKGEITAEEYEKFIEKEIQECVNIQEELGLDVFVHGEPERNDMVQYFGERLDGYVFTTHAWVQSYGSRCVRPPILVGDVSRPAPMTVKESKYAASISKKPMKGMLTGPITCLRWSFPRDDVHQSVQAQQLALALRDEVVDLEAAGVYVIQVDEPALREGLPLRSGSEREKYLEWAVNSFKLSTAGVEDSTQIHSHFCYSEFQDFFHAIAALDADVLSIENSKSDAKLLKVFIDEAYPRHIGPGVYDIHSPRVPSEQEIKDRIQEMLQYLKPDQLWINPDCGLKTRQWKETKAALVNMVNAAKYFREQHSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>M3ATA2</accession>
    <name>M3ATA2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Multidrug resistance protein 1, 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SEPMUDRAFT_72865</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756865.1">
        <property type="nucleotide sequence ID" value="XM_016910006.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.M3ATA2"/>
    <dbReference type="GeneID" id="27907143"/>
    <dbReference type="eggNOG" id="KOG0055">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_17_2_1"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000102">
        <property type="entry name" value="ABC multidrug transporter Mdr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000913">
        <property type="entry name" value="ABC multidrug transporter SitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000251">
        <property type="entry name" value="ABC transporter B family member 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF16">
        <property type="entry name" value="ABC TRANSPORTER B FAMILY MEMBER 4-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="54"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="711"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="754"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="833"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="859"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="942"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="974"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="57"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="381"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="713"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1035"/>
            <end position="1296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMF08744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1307" mass="142167" checksum="56CED242D9DD9182" modified="2013-05-01" version="1">MASHATQGDSANSDPFGHLPHHEALILRRQLEKPDAAKATWSSLFRFASRQDMVIIAVSSICAIAAGAAVPLNTVILGSLAGAFQDFTNGISRSEFDARVNRQTLYFVYLAVGEFFTIYIATIGFKYTGESITRKIREQYLKALLRQNAAFFDQLGPGEIITRISADTNVVQEGLSEKIELALSAISTFIAAYVVGFVKYWKLTLIMTSMTPVMVLLMYGLKEYVVKYTKLSLAAHGQGVVVIEEALSSIRTVTGFGTQESLAKEYNKSLDRAQAFGLRAKCIMASGVGALIGIFNLGYALASWMGSKYIISGETNLPAVFTILLVLMLGSFALGKAVQHIQAFVEAAGAASAIYATIDRVPPWGEHTNQGKVMEKVEGHIELRNVKHIYPSRPDVVVMQNLSLNIPAGHTVAITGPSGSGKSTIVALLERFYSPVSGELLLDGCNIEDADLHWLRQQIGLVSQDPNLFSGTVEDNILHGLRGAAITGEHSKRYLAEKAARLADAHEFIMMLTKGYDTFIGERGSSLSGGQRQRIAIARAVVSDPKILLLDEATSALDSKTEEVVQAALERAAQGRTTIIISHRMSTIKNVDTVVVMAAGGKIVEQGTYEDLLAAKGAFYELVEAQNMAQNTKSTGVDWDEKANPWPYEAAGGEKALDLQSVRKISLDSLSDADAVPVDDSATTIEKPRRKASLWSLIQFTCSMNRKEWKVMLLGIIASIVSGAGEPVQCVILAKAIVTLSLPPSQYLRLRSDIALWSGMFVMIAFVMLACSTVLGLSFAYGSERLIHRSRDQAFRSILRQDITFFDRPENTVGSLTSFLSTETTHLAGMSGLALGTIFQLLATLIIGYIVALAVGWKLALVCIATVPILLLAGFLSIYSMSRFEAHLKDAYRESASYACEATSSTKTIAALTLENEVWQKYHNLLVAQASRSFRFNVKSSVLYAASQSLGFLCMALAFWYGSSLIGTYSLEQFYLVFFLVIFGTRSAANMFSLAPNMAKAKVAAAELKTFFEQTPAIDVWSSDGDVLDHLQGSIEFRDVHFAYPTGQPVLAGLNFKVQPGQYVALVGASGCGKSTTIALLERFYDPTNGTIYVDGKDITTLHLSSYRKHIALVLQEPTLYQGTIRQNLLLAINRQDEEDEEEDEKGKAKSQNMTTIVPEEKLIQVCKEANIYDFITSLPAGFDTVVGSKGCMLSGGQKQRIAIARALLRDAKILLLDEATSALDSESEGVVQKALDAAARGRTTIAVAHRLSTVRNADAILVFDNADGKGGRIVESGTHATLMALRGRYFELVQLQSSESNEEVVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>M3AW68</accession>
    <name>M3AW68_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_118303</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF10990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759111.1">
        <property type="nucleotide sequence ID" value="XM_016901418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AW68"/>
    <dbReference type="GeneID" id="27898555"/>
    <dbReference type="HOGENOM" id="CLU_2279248_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF10990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="102" mass="11306" checksum="A3FAE5FBE0720759" modified="2013-05-01" version="1">MIWLSSSTKQHPPATRIIVTRVPTVEESGEESDMMLLSLSVAAAAILPPPPPLQRPFPLAVGSHGVITGSASRDFTLTFRAIHRERHGFYWLRTLPCLCTQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M3AWQ4</accession>
    <name>M3AWQ4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein arginine methyltransferase NDUFAF7</fullName>
            <ecNumber evidence="7">2.1.1.320</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_164721</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48108"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:88221"/>
            <dbReference type="EC" id="2.1.1.320"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NDUFAF7 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.320" evidence="7"/>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759281.1">
        <property type="nucleotide sequence ID" value="XM_016908130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AWQ4"/>
    <dbReference type="STRING" id="692275.M3AWQ4"/>
    <dbReference type="GeneID" id="27905267"/>
    <dbReference type="eggNOG" id="KOG2901">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024840_0_0_1"/>
    <dbReference type="OMA" id="YYHPQRN"/>
    <dbReference type="OrthoDB" id="5595109at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035243">
        <property type="term" value="F:protein-arginine omega-N symmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12710:FF:000004">
        <property type="entry name" value="Protein arginine methyltransferase NDUFAF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003788">
        <property type="entry name" value="NDUFAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049:SF7">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02636">
        <property type="entry name" value="Methyltransf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="511"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF11160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="531" mass="58203" checksum="A98CDF4B3265C945" modified="2013-05-01" version="1">MRSSLSRTAWQLGQNACRIRTRPCRVAGARWSSSESGHKWSTPLAKQLAEAIITTGPIPVASYMRQVLTSDLGGYYTGALSGDRDQFGTKGDFVTSPEISQIFGELIGVWVVAEWMAQGKKSEGVYLMEIGPGRGTLMSDMLRTIRNFPPLAKAIEAVYLIEASETLRLAQHKLLCGDNPMTETKLGWESVSKHSSEIKVVWTEDHKFVPRHASKTPFIIAHEFFDALPIHVFQSTHIQPDQAKTIQTPTGPIQNRSRTQESQQWRELMVSAKPPHRLKEGEPEFELSTSRTATAHSMYLPETSPRYKALKTTDGSTIEVSPDSQSYARDMAVRIGGSNPDEIAAYAKRKAPIPGRSTASTPEIPISRPSPSGAALIIDYGPPDHIPINSLRGIRAHKLVSPFDRPGETDVSADVDFLALAETAINSSPGTEVHGPVSQANFLNAMGIQERAAQLVKKALDDERAGRGGGKDKSELTEIVKRVESGWRRLVDTSPQGMGRLYHVMAIVPYSPPKEGQPRRRPVGFGGDIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>M3AYG3</accession>
    <name>M3AYG3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_149200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760688.1">
        <property type="nucleotide sequence ID" value="XM_016905406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AYG3"/>
    <dbReference type="GeneID" id="27902543"/>
    <dbReference type="HOGENOM" id="CLU_2544054_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF12567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="83" mass="9596" checksum="D007D26222946F2D" modified="2013-05-01" version="1">MVHAVTALVHSLSTRNSRLHLHVMVESRIAKYDPDMARRHSDAPRWSLDAAGHHMLRRTIASAITYDWRADRHSQWEVGGSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M3B3M2</accession>
    <name>M3B3M2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N,N-dimethylformamidase beta subunit-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_148093</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762483.1">
        <property type="nucleotide sequence ID" value="XM_016904698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B3M2"/>
    <dbReference type="STRING" id="692275.M3B3M2"/>
    <dbReference type="GeneID" id="27901835"/>
    <dbReference type="eggNOG" id="ENOG502SHA1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013754_0_0_1"/>
    <dbReference type="OMA" id="GGRLMYM"/>
    <dbReference type="OrthoDB" id="5287072at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046540">
        <property type="entry name" value="DMFA2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20254">
        <property type="entry name" value="DMFA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N,N-dimethylformamidase beta subunit-like C-terminal" evidence="2">
        <location>
            <begin position="315"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF14362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="790" mass="87296" checksum="6C685D66197147D9" modified="2013-05-01" version="1">MEEKKKKNHHTMNLSQKPITDDIAPTTDEDEIIGYADPWIVSPGDLVNVKVSSTDAEYRWSLIRLINGLLPLPEAPPLRSEIIIPESSKTQQHGSFKLAAPGSYAVVDSWPLEGNNTVMEAGGRLSGVRLGFFVQPWMTECRHLQTLVSTLDVDSLAGFALFLDTSGQLCCIVGDGSTVQRQNTGIHLRRWRWSRISCTIKGRQVRLQVVPVSRLVEPAPASSVFENCAINEVKFAGNVPLTLAAGFFGFEQQATLKPDSCFSGKLDSFTLETQHSTAGDFSLWAQYDFAKDINSDRVVDTSGANRHGQLKNAPTRAVKGHDWDGSEPDWTKAKYGYGAIHFHDDDLDDADWPTDFTVTVPDDAVSGAYGVAVKGTSSGTEDIITFFVTPKHDRVTTRRGAPVAFVMPTFTYLAYANERMYDQDRASRLELAGGVSMRKDKHFARMNRRSDLGISMYDVHNDGSGGVFSSAKRPILNMRPDYINWAFHRPREFPADLLMLGFLEKHLGKGGYDVLTEHDLHLRGFSAVQHYNVLITGSHPEYPSLTELDVYAEYLKTGGSVMYLGGNGFYWCSETHPERPHRMEVRKGDQGCRSITLPAGERIHQINGAHGGLWRSRGRAAQVMFGVGSDACGSGPGVPYRVYQHVLQQKEFSWLWRDLQPDSSGNLLVGSEGFGGGASGDEIDRLDYDLGTPSNAVLLATANDHDDSFALFNEEAMFPMINTTASVCDKVRSDMVYYETSAGGAVFSVGSINWYCSLGWKAYDNDVAVLTRNVLDEFMRKGASKGEPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M3B430</accession>
    <name>M3B430_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_132169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762653.1">
        <property type="nucleotide sequence ID" value="XM_016902478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B430"/>
    <dbReference type="GeneID" id="27899615"/>
    <dbReference type="HOGENOM" id="CLU_1016230_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004031312" evidence="1">
        <location>
            <begin position="20"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF14532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="274" mass="28517" checksum="2479A29C99E45721" modified="2013-05-01" version="1">MHFNLLTLGALATTTSTLALPVLSPAKRQVENTLQIVQATYKQVTQYTSAINSTLDAIHVEGVSAAGIDVASVQETVKGEIASIVKILDSVLDVTSDLTVVDDVDRVLEVVTSATEGVPAVSSLESAILKRLVADVDSVVGVNTEELTKDLLPLSAVVEARDLVSAPLDLESLLDTESLVEDLPVVGKRQSVADISGVTGYATAMVSEITSTVGEVSKVVPGVELGDSIPQLSVAITTFITDLDNVVEGVEVAVTNVLKNVPVSVSVLDTTIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M3B5L1</accession>
    <name>M3B5L1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoglycerate mutase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_147054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763198.1">
        <property type="nucleotide sequence ID" value="XM_016904056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B5L1"/>
    <dbReference type="GeneID" id="27901193"/>
    <dbReference type="eggNOG" id="KOG4754">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039184_0_1_1"/>
    <dbReference type="OMA" id="TCDHRRS"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF1">
        <property type="entry name" value="HISTIDINE PHOSPHATASE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032064" evidence="1">
        <location>
            <begin position="21"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF15077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="384" mass="42861" checksum="EE24F41389D0A7D1" modified="2013-05-01" version="1">MIWSSLTWTALAAFCVGVSSRKITPYTDGYINYTTVPGYFLQDDPTTNASTFNYTLTNFGLINRTYETTNNLAESLTQWQQFKQHVEAMNAAAPPNTVYKVLFMGRHGEGYHNVAESAFGTPAWNCYYAQLPGNGTLFWEDAQLTHTGIFQAEIAHNFWKNRIRIEKIPFPRSFYTSPLQRCLATANITFGDLSDLLSLDSPSSSSSSSSVFQPTIKDLLREKISIHTCDHRNSTATSLLQIYPHFLLEPGFSEFDHLWNGLTAESDTAHSIRMQNFLDDIFSHDEHTWISLTSHSGTIAAILRVIGHQGFRLATGGVLPVLVRGEFLPSSSSSCIEDGATSVTTMMTTMTSMVESSYYTTSTWCHNGPPVCYEAIREQHVTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M3B847</accession>
    <name>M3B847_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Multiple myeloma tumor-associated protein 2-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_16438</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF16012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764133.1">
        <property type="nucleotide sequence ID" value="XM_016908112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B847"/>
    <dbReference type="GeneID" id="27905249"/>
    <dbReference type="eggNOG" id="KOG4520">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061193_5_0_1"/>
    <dbReference type="OMA" id="KDLQWYA"/>
    <dbReference type="OrthoDB" id="5973539at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019315">
        <property type="entry name" value="MMTA2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039207">
        <property type="entry name" value="MMTAG2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14580:SF0">
        <property type="entry name" value="MULTIPLE MYELOMA TUMOR-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14580">
        <property type="entry name" value="MULTIPLE MYELOMA TUMOR-ASSOCIATED PROTEIN 2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10159">
        <property type="entry name" value="MMtag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Multiple myeloma tumor-associated protein 2-like N-terminal" evidence="2">
        <location>
            <begin position="11"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF16012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="109" mass="12428" checksum="9EBC213BCA84008D" modified="2013-05-01" version="1" fragment="single">MDLLQSVRKEGSRGGVNFSWDDVKGATNRENYLGHSLMAPVGRWQQNKDLNWYAKADDADLTPEQRMEKEREAKREEMRKVKEAEEDAMNLALGLPVPDRTNANLQPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M3BPF9</accession>
    <name>M3BPF9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_136875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF08053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756174.1">
        <property type="nucleotide sequence ID" value="XM_016902808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BPF9"/>
    <dbReference type="STRING" id="692275.M3BPF9"/>
    <dbReference type="GeneID" id="27899945"/>
    <dbReference type="eggNOG" id="ENOG502SN14">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038193_1_0_1"/>
    <dbReference type="OMA" id="CEMNILT"/>
    <dbReference type="OrthoDB" id="5598852at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF59">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="104"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF08053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="340" mass="38104" checksum="533507EBF159FA24" modified="2013-05-01" version="1">MSPTPYSLSTSISTFLSTHSSTTRSECDSLAQSLLSSPTISPVPIQGSFSYTVVASDSQLAQFRSPTSPLDVEVLRLAREIYGGDVVAKTEFWGNFGGLGVYLIEKLQGVTYLEWLMKGGLGRRLDGERFERQRGLVGDFARFFAAAWKTPQTADIAATRQTCENNLHLLARNLPDRFSRDILELTECLDSIFQTLPMVLTHGDLCEMNFLVDERSGHLTGVIDWAEAEILPFGFNLWGVENLLGYMDGNGWNYFEGYEELRGEFWTVFYGAVGAEEEEGEGDGVLASEVLCQKQETIDVARRMGILFRYGFFWDEDLRKKVPVQEGDSGMRYLDAFFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M3BPU7</accession>
    <name>M3BPU7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_152447</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF08193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756314.1">
        <property type="nucleotide sequence ID" value="XM_016907451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BPU7"/>
    <dbReference type="STRING" id="692275.M3BPU7"/>
    <dbReference type="GeneID" id="27904588"/>
    <dbReference type="eggNOG" id="KOG0154">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_842408_0_0_1"/>
    <dbReference type="OMA" id="AYGQPEK"/>
    <dbReference type="OrthoDB" id="29221at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13948:SF3">
        <property type="entry name" value="FI21118P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13948">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="G-patch" evidence="5">
        <location>
            <begin position="251"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="44"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="103"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="293"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="294"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF08193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="330" mass="36120" checksum="F4F8BB6CF885B9EA" modified="2013-05-01" version="1">MGVFPAVLHGQETLDSKYMFQFKDGTSHRYHDARYYASVLDINMQPPSRSTNVSDAENVKKSKKRSKDPNAGDTLDSSAKKAKVGSSKSLGIVDQWNKKKAELRGEPVERLRSHSPRSEPDTTAQNPPQQSYVFEGQKGGKQRKVCLLCATEIPKQVTAAAHVLGSKLHAANLLDEAKCQKALQKIVEWAGITPDQTVQVRPDAPEKPKVIRDRAKERREQEARTGTTEKLKVSLKDVKKGGPVGKPVDPSYGKGMAMLQKAGWKEGQGLGSGGGISAPIQQISYNAGVGLGHEGSKKGDAVEEATRMTRDDGGFLEKTKEVARQRFERM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M3BRV8</accession>
    <name>M3BRV8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_158954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756969.1">
        <property type="nucleotide sequence ID" value="XM_016907815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BRV8"/>
    <dbReference type="STRING" id="692275.M3BRV8"/>
    <dbReference type="GeneID" id="27904952"/>
    <dbReference type="eggNOG" id="ENOG502SIQP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004184_7_5_1"/>
    <dbReference type="OMA" id="IDSHIMA"/>
    <dbReference type="OrthoDB" id="3634498at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="62"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF08848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="642" mass="72270" checksum="2D0E569EDA7BA718" modified="2013-05-01" version="1">MANLDHPITPDDIGNVKYSYDSLDSSKNEIRLLKFSKDTSDSTWSSTACSVVTVALPEAPAYCAISYVWGDPTHLRDIELDGLQVPVLATAVEALQQMHAAAFIASSHTAYIWVDAVCIDLDNDQERAQQVMIMSEIYSNATQVLAFLGLSFSGHVEIQSSICASARALREAAGSRKGLNRLLNFDTDLSVAEYLNGLDKALLAKFYASPWFTRLWILQEAALARVAMVFYGDHSIPLPDVIIVARALVKMERHSGRFEVSRDALSHGIRHCKTLFNLRVWHACKLNLAHEGDCRRGQCHSGLPLTYLLEVMHNHANSEMRDKVYAILGLAHVSVAHDLRPNYNLPLEVVYTQATRLAFQQDNSYEVMRWARTNGNHLNEWYREHHWPTWLPLWQEPYGRLKNPSGLPWWTFRASNSRTVIFPTELSDPVLRCEGVFIDDLQYTSSTLLPGGKFKEDDQTALQALQDAIRVFSPMAQKARGVRSDIDIDSHIMALAGTLAAGALRLRSQDEYNARQPPPRNNKAVLTASELAEMAHSSLTRNADASSAGQAMKYLYHFQFHSRFRKFFLTKDGYMGIASQHVRMQDSLFLAMGNSVPWILRREEGHYLFMGVCYVHGIMQGELASELGVEDIAEKAQWVNIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M3BTK4</accession>
    <name>M3BTK4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_151051</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF09970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758091.1">
        <property type="nucleotide sequence ID" value="XM_016906565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BTK4"/>
    <dbReference type="GeneID" id="27903702"/>
    <dbReference type="HOGENOM" id="CLU_2265411_0_0_1"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF4">
        <property type="entry name" value="CYCLOCHLOROTINE BIOSYNTHESIS PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF09970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="103" mass="11925" checksum="C9D94A79DCE65807" modified="2013-05-01" version="1">MIHKRLLDPSGFTPRDCSGLEWGFDAEDGYNQTLQTACHIQHCVDWIRQDIMCLADPTLEPFVIADEVRFEPEYHQCRSFENVRSWAQRNEYPGSMASLQAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M3BTP0</accession>
    <name>M3BTP0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_151069</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF09995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758116.1">
        <property type="nucleotide sequence ID" value="XM_016906575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BTP0"/>
    <dbReference type="STRING" id="692275.M3BTP0"/>
    <dbReference type="GeneID" id="27903712"/>
    <dbReference type="eggNOG" id="ENOG502S9KM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131051_1_0_1"/>
    <dbReference type="OMA" id="FNTNDGY"/>
    <dbReference type="OrthoDB" id="3556830at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020999">
        <property type="entry name" value="Chitin_synth_reg_RCR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28187">
        <property type="entry name" value="PROTEIN RCR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28187:SF1">
        <property type="entry name" value="PROTEIN RCR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12273">
        <property type="entry name" value="RCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF09995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="150" mass="16633" checksum="22581C10AA56F593" modified="2013-05-01" version="1">MDSIRSIQARQVYYGGYGRRRYGYSRWNHWGRWVLLGVILLVALVVLLLFSCVTARRRRKMGRKPFMGTGWAAPNNGASNGDSYKPPQQMQQQGNNSQYPSGPDQQPYYAGGGGGQASEYYNSNSAPAYDGVAQPGTYQAPSYPPPAQTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M3BU79</accession>
    <name>M3BU79_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_151227</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758356.1">
        <property type="nucleotide sequence ID" value="XM_016906682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BU79"/>
    <dbReference type="STRING" id="692275.M3BU79"/>
    <dbReference type="GeneID" id="27903819"/>
    <dbReference type="eggNOG" id="ENOG502S3PM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061001_1_0_1"/>
    <dbReference type="OMA" id="IRCHADW"/>
    <dbReference type="OrthoDB" id="5357075at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF10235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="333" mass="37424" checksum="C9A1929E9B118D22" modified="2013-05-01" version="1">MLPVLVHYCDTCGYNTPVQYNSVLVWIQEHTCNHCGTKALGADIAGRSQGTMNQYQHDELSQLFANLSTEQQQKVIAEPQYEGQARAIVEQMQMMPEKVEAPLTFASAHYTHSTHLTADTQPEPAQSPPPPYREAIMPEAMAEMLTQNSIDPASLLPSQIELFAGADYEQRLRLLELWRIAPPSYPHEQHVHAQHEQTSVEKEEVDARARYEQQMQARVNPREAYGFDMYSSEPVSPVSAVVKPRAASFASGGGYLGKGEAEPYMSNGYQQMHSDPVYAAGLWQSSYAQAQPGTAMEDQYGMYEQIRCHADWERMNQRAMDAQLGQVDDDMVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M3BVE0</accession>
    <name>M3BVE0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I, II, and III subunit RPABC5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_150260</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759420.1">
        <property type="nucleotide sequence ID" value="XM_016906056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BVE0"/>
    <dbReference type="STRING" id="692275.M3BVE0"/>
    <dbReference type="GeneID" id="27903193"/>
    <dbReference type="eggNOG" id="KOG3497">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_143122_2_1_1"/>
    <dbReference type="OMA" id="YCCRRMF"/>
    <dbReference type="OrthoDB" id="10258858at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000024">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00250">
        <property type="entry name" value="RNApol_arch_Rpo10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023580">
        <property type="entry name" value="RNA_pol_su_RPB10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020789">
        <property type="entry name" value="RNA_pol_suN_Zn-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000268">
        <property type="entry name" value="RPABC5/Rpb10"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003089">
        <property type="entry name" value="PRK04016.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431:SF3">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01194">
        <property type="entry name" value="RNA_pol_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005653">
        <property type="entry name" value="RNA_pol_N/8_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46924">
        <property type="entry name" value="RNA polymerase subunit RPB10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01112">
        <property type="entry name" value="RNA_POL_N_8KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF11299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="81" mass="9307" checksum="DE3A1EB4F7C9CC8A" modified="2013-05-01" version="1">MIIPIRCFSCGKVIADLYERYVELIGTVQDNGDTVSDGDAMDQLGLNRYCCRRMMLTHVDLIEKLLRYNPAERDIIKPGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>M3C033</accession>
    <name>M3C033_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_148901</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761802.1">
        <property type="nucleotide sequence ID" value="XM_016905217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C033"/>
    <dbReference type="STRING" id="692275.M3C033"/>
    <dbReference type="GeneID" id="27902354"/>
    <dbReference type="eggNOG" id="ENOG502QVF9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009617_1_0_1"/>
    <dbReference type="OMA" id="PSHFIGN"/>
    <dbReference type="OrthoDB" id="2283631at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF79">
        <property type="entry name" value="C6 FINGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="35"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="159"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="669"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="678"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF13681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="898" mass="100738" checksum="B3892DF8D6D3B49F" modified="2013-05-01" version="1">MEDTTTSAPAPAAHTKQYVFVDEYNRHKRLKVMRACDGCRKRKIRCDGALQNGPWPCGACVRLKLKCIPPTLDQDDDSHPPNGTTGQQTFPFQNTTFPATIPVDSKSTGLHTEPRMVHDWSNNVPPATTTGALTSAPSYQLDYASNAYSHQPIARLTQPGYPQDSYYSTTSQYQQGSHESSLSRTCRETPESSSGDAQEIEAGVRELSSHMGDLQIDITSAAPYITRTQMAPDAPALEEAEVVLPASIMADASIRIPPEMMPSEERATYFFNYYFDHIHPYCPVLHRATFLEQWRSNRHSMSPLLLEAIFACVARYLEQPVESRKWLALAARHEESFKDVPRLETIQAMIILMKARESISKRGYYYRSWMAVKYMTTCGIDLRLDVHHEQHQTMNRCSYDRIECMLRTRIWQTLFVLEILTGAPLGRSDFSIDIDTVQYTMPLPTNDIDAFEHLSSRRSTILAQNVRNIKQSNILWQTMKRYKKDWALDPAFVQHNEDLPVWAETLPNDFQLQYADDGSPPWLGADHFKAYVHVYHHLTVIMHHRPQLQALLAKGDPGWKAQLDICLSSASLMCRTQEALYRDFQFHGLQFMIRGVNFTIYCVLTCMMLHLAAITCPDPVLNSQARLYFTRHMRVLEHCITSANAEMQAQINTLREAFSADVTQPFELKPTLGLRSPTMENQLTPSSTKSDPASSRVLTQPSWSMAETAVSNPLAVGAGYATAFDTASPHGMSSRPPMPHHNSSFDLSQPYTPSSMHHVSTSQAGYALEPVVSNEQHTPVWDPSGIFNQWNAAFGGGPPPQATPPGSTNMQHTSAPMMANQTSPISTHTIYAGPQLPVSGNPTMPDSTPPAMPMVTPVMWQDAFTSAYVSGHGQKRYREASVDHTAYHQYPATSKRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M3C0V7</accession>
    <name>M3C0V7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycoside hydrolase family 30 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_149046</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 30 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762037.1">
        <property type="nucleotide sequence ID" value="XM_016905305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C0V7"/>
    <dbReference type="STRING" id="692275.M3C0V7"/>
    <dbReference type="GeneID" id="27902442"/>
    <dbReference type="eggNOG" id="KOG2566">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014379_3_1_1"/>
    <dbReference type="OMA" id="NEPLNRG"/>
    <dbReference type="OrthoDB" id="2160638at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004348">
        <property type="term" value="F:glucosylceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006680">
        <property type="term" value="P:glucosylceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033452">
        <property type="entry name" value="GH30_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001139">
        <property type="entry name" value="Glyco_hydro_30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033453">
        <property type="entry name" value="Glyco_hydro_30_TIM-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069">
        <property type="entry name" value="GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069:SF23">
        <property type="entry name" value="LYSOSOMAL ACID GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02055">
        <property type="entry name" value="Glyco_hydro_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17189">
        <property type="entry name" value="Glyco_hydro_30C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032463" evidence="5">
        <location>
            <begin position="21"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 30 TIM-barrel" evidence="6">
        <location>
            <begin position="80"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 30 beta sandwich" evidence="7">
        <location>
            <begin position="418"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF13916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="488" mass="52246" checksum="96518DDB30C97B0C" modified="2013-05-01" version="1">MLLLSFLTAIIASGPPATAAASLLETRQSTPASAVCSNYNGTYKLTNITAPVRGLGTQPAGSQPWGLFLNDTAAAYRQNVTGFGAAVTDATVVNFNRLTSAQQTSLLNVLMTAGPSNSANFSLMRHTIGSSDLSATNYTYNDGARDPSLANFALGPNGTAMASLLAKMRTSAPAMTLLGSAWSAPGWMKRNGALTGNATNNNLLDRYLDPTEDNLADPYANYFVKYLQAYANAGAPVNAITIQNEPLFSTASYPSMYVYDYENAALIQKFVGPAITRASLNTQIWGYDHNLDQPVYAQRILDNAPVNTIAWHCYSSQPWSVMSDFKANNTGVIQYMTECWTPSSQPWYNAAAFTLGPLQNWGSGAIAWNLASDVNNGPYIYGGCSSCQGLVTVRNDRTYTLNTAYYMMAQFSRYMPKGSTVVPLTGNGGNGNGDVQSIATVNPNGSRTVVILNTFANPVFMQMNTTSGTVWSGSLPPSSVVTWVLPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M3C4W0</accession>
    <name>M3C4W0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MOSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_147243</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763447.1">
        <property type="nucleotide sequence ID" value="XM_016904171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C4W0"/>
    <dbReference type="STRING" id="692275.M3C4W0"/>
    <dbReference type="GeneID" id="27901308"/>
    <dbReference type="eggNOG" id="KOG2142">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028286_3_0_1"/>
    <dbReference type="OMA" id="RYGFCYG"/>
    <dbReference type="OrthoDB" id="3641012at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOCOS_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141673">
        <property type="entry name" value="MOSC N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="MOSC" evidence="2">
        <location>
            <begin position="231"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF15326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="412" mass="46043" checksum="53A807CFA53FE8AB" modified="2013-05-01" version="1">MMAVPLSLTEHLNRLVPLHLLVPAIIIVITLLAAGALVNSSAIKDIYEPKEKPIITVEELWHYPVKGLGGIKLDKATIGRQGFEHDRTFVLVKVHRDEKTGEVAVLEPMYSGFNLHMVLFQCIIEDREKGPEHASITITRVGPENPNPTQLTYTGHSEHQIRFPLQPDMKTLVKTNMDMHGSACEVFDMGSEISAWLSKYVQHETKLFYIGSNARVVLGSGAPNSPEAIEKRSPASALIRKILPKPLVTPTETITFQDIGQYLVVTRESNADISSRLDGSTEMDIHKFRPNIIVSGAPAAFDEDFWSQLVFPHNIHMDFGGTCWRCQAITVDTKTGKKAEGPEGEVWKRLNQYRRVDKGWKYGPVFGKYSYTSLKDCGKTIQVGDQAVLTKRVKEQPIFDWPLPKAVVAAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M3C5I1</accession>
    <name>M3C5I1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_105770</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LU7TM family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763642.1">
        <property type="nucleotide sequence ID" value="XM_016900589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C5I1"/>
    <dbReference type="STRING" id="692275.M3C5I1"/>
    <dbReference type="GeneID" id="27897726"/>
    <dbReference type="eggNOG" id="KOG2568">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024065_1_0_1"/>
    <dbReference type="OMA" id="TWGFYDF"/>
    <dbReference type="OrthoDB" id="48651at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053937">
        <property type="entry name" value="GOST_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009637">
        <property type="entry name" value="GPR107/GPR108-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053938">
        <property type="entry name" value="PTM1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229:SF1">
        <property type="entry name" value="GH17801P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229">
        <property type="entry name" value="LUNG SEVEN TRANSMEMBRANE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06814">
        <property type="entry name" value="GOST_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21902">
        <property type="entry name" value="PTM1-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="242"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="399"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="PTM1-like N-terminal" evidence="10">
        <location>
            <begin position="10"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="GOST seven transmembrane" evidence="9">
        <location>
            <begin position="175"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="458"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="512"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF15521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="533" mass="59252" checksum="EF611DA3C3D88BB7" modified="2013-05-01" version="1">MSIDQKDASRQACAGMYSRKTWGGHVDPYILVKFVRPDSVPEGEDPIVSLVIFEWKDRSLIGKPDPKDEMVSAVGGRVMANGIQDDYLCDEAARDAGLCEEADVGSFILATNASAASKSLIRSEAVHLKDPGAINYPIKKTGYYCVSSAAYSATEYIGIVEFRNAFGELPAAQIPKLPFYAGFTIVYAFVAMGWGVLYWMHRRDILAVQNYITAILVFLIIEMFMTWLFYDFQNRHGLNGGAKALLIVVSILSAARNSFSFFLLLIVCMGYGVVKHELGKTMWYVRALALTHFVFGVIYAIASLAVTPENAGPMVLLVVLPLAGTLTAFYIWTLNSLNYTMKDLVERKQHVKAGMYRKLWWCILTSIVVIFAFFFVNSWTFAGSGNADFVPNHWQSRWFILDGWLLLVYFCDVSFIAYIWRPSANNRRFAMSDEISQTDDGFEIASIRDSMDLDDDLEAVSGNGNKAPPPYDAPLGGSSNPRRDASPLPAPKPTKPAQLPRESLDGETIFAVDDDSEDEDDMGEGKRLNGKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M3C5K7</accession>
    <name>M3C5K7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2-isopropylmalate synthase</fullName>
            <ecNumber evidence="7">2.3.3.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SEPMUDRAFT_60511</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21524"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.13" evidence="7"/>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763672.1">
        <property type="nucleotide sequence ID" value="XM_016909528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C5K7"/>
    <dbReference type="STRING" id="692275.M3C5K7"/>
    <dbReference type="GeneID" id="27906665"/>
    <dbReference type="eggNOG" id="KOG2367">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004588_3_0_1"/>
    <dbReference type="OMA" id="WPDKVID"/>
    <dbReference type="OrthoDB" id="418791at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07942">
        <property type="entry name" value="DRE_TIM_LeuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000045">
        <property type="entry name" value="2-isopropylmalate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.270:FF:000002">
        <property type="entry name" value="2-isopropylmalate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00572">
        <property type="entry name" value="LeuA_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005668">
        <property type="entry name" value="IPM_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054692">
        <property type="entry name" value="LeuA-like_post-cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039371">
        <property type="entry name" value="LeuA_N_DRE-TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00970">
        <property type="entry name" value="leuA_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002991">
        <property type="entry name" value="PRK03739.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46911">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46911:SF1">
        <property type="entry name" value="2-ISOPROPYLMALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22615">
        <property type="entry name" value="IPMS_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89000">
        <property type="entry name" value="post-HMGL domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="15">
        <location>
            <begin position="33"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="464"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="589"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="627"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMF15551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="644" mass="70995" checksum="1968E69452066F8C" modified="2013-05-01" version="1">MTMLKDPSKKYRRFKPLKLENRQWPSKELTKVPRWLATDLRDGNQSLVDPMDAEQKWKYFEMLVKLGYKEIEISYPSSGATDFDFTRRLVTTPGVVPSDVWLQVLSPCRKDLIKKTVESLKGAKKAILHLYLATSPCFQRIVFGMNNEQSKALAVECTKYARSITKDDPNSGVEEWAYEFSPETFSDSDPEFVIEICEAVKAAWEPSKEQPLIFNLPATVEMSTPNVYADQIEYFCTHITEREKIAVSLHPHNDRGCAVAAAELAQMAGADRVEGTLFGNGERTGNVDLVTLGLNLYTQGIHPGIDFSDINSIIDVVEKSNKIPVHPRAPYGGSLVVCAFSGSHQDAIKKGFVIREKENAGHEDPWTMPYLPLDPRDIGRTYEAVIRVNSQSGKGGVAWIIKRTLELDLPRGLQVDFSKIVQRETDALGRELLANEIKDLFVDAYHLNRNPRFSLVDYDITTDRSSSPAPPAANEGEKKSASNKNLRRRFKGVIEIDGQEHEVAGVGNGALSALANALKNLGIDLDIADYKEHAVQRNTGKGRDTQAATYIECTNADAHQKVWGVGIHEDVVQSSLFALLGAASSFLTSRPGSPFKPKRSNTGLLDVKGSGPDLTAQNPSGAPESSPDAQQSVQVNGAQGLNGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M3C5Y5</accession>
    <name>M3C5Y5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cloroperoxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_154451</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763812.1">
        <property type="nucleotide sequence ID" value="XM_016907563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C5Y5"/>
    <dbReference type="GeneID" id="27904700"/>
    <dbReference type="eggNOG" id="ENOG502S6CG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029871_3_2_1"/>
    <dbReference type="OMA" id="HTADAYN"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF1">
        <property type="entry name" value="HEME HALOPEROXIDASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 10" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032322" evidence="8">
        <location>
            <begin position="18"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="9">
        <location>
            <begin position="60"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF15691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="423" mass="44396" checksum="1382176967DDCBD9" modified="2013-05-01" version="1">MVQSWFALAALAGSAAAWPMVMEQDMLLKRAASGRLNTGAGHPNPTFDAQSQYVDVSDNGPNPFMPPTSGQLRGQCPGLNAAANHGFLPRNGRATIEQTVTGLGNAYGMSADLSIVLAAIAILISGDIPTGEWSIGGGFPSSLPLVLSNPKGILGTHNKYEGDASIVRGDAYLNNGNVGVFQWQSWNDLYEITGTDGLTLDKVTAHSDRVTEFSVQNNPYYFSGPFSGLVAPAAHNFVVNFMSNHSAEYPGGYLSREVLMSFFAVSGDATGAYGTNPGNFVHNRGQERIPYNWYRRNTVDAYTAVDVFLDLLAGAASYPNTLRIGGNTGTTNSFTGVDVGDLSGGVFNAATLFQGNNLACFAIQAAQAGGIDELDGVLSTVQNLVKPLTDQLSGALSSLGCPQLSAKGLNSQLFAAYPGARSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>M3C7X9</accession>
    <name>M3C7X9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_152311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF07995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756116.1">
        <property type="nucleotide sequence ID" value="XM_016907368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C7X9"/>
    <dbReference type="GeneID" id="27904505"/>
    <dbReference type="HOGENOM" id="CLU_3070182_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF07995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="53" mass="5756" checksum="2ACC1A2F89B2675B" modified="2013-05-01" version="1">MSLDDRDCGMFNLENDERRIPRGEPLIMHPANSSQPIGQPVGQSFGQSIGLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M3CAT1</accession>
    <name>M3CAT1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome c oxidase, subunit VIb</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_151817</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome c oxidase subunit 6B family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757041.1">
        <property type="nucleotide sequence ID" value="XM_016907064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CAT1"/>
    <dbReference type="STRING" id="692275.M3CAT1"/>
    <dbReference type="GeneID" id="27904201"/>
    <dbReference type="eggNOG" id="ENOG502S7HF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142408_0_0_1"/>
    <dbReference type="OMA" id="CAKAWVK"/>
    <dbReference type="OrthoDB" id="5545577at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.140:FF:000003">
        <property type="entry name" value="Cytochrome c oxidase assembly factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.140">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048281">
        <property type="entry name" value="COA6_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048280">
        <property type="entry name" value="COX6B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036549">
        <property type="entry name" value="CX6/COA6-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47677">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47677:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02297">
        <property type="entry name" value="COX6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47694">
        <property type="entry name" value="Cytochrome c oxidase subunit h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF08920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="110" mass="12407" checksum="CFD1D1FC2667AD90" modified="2013-05-01" version="1">MGLFSSSQTQTKPPQPEASKDGGFIAPDRTARAQCWEGRDAFFACLEKNGIIDSVREDKKAREQCAPELAQFEKTCASSWVTYFKKRRVMEYQRDLTIKKLSAQGVQGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M3CCM8</accession>
    <name>M3CCM8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7730 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_110545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758278.1">
        <property type="nucleotide sequence ID" value="XM_016900850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CCM8"/>
    <dbReference type="STRING" id="692275.M3CCM8"/>
    <dbReference type="GeneID" id="27897987"/>
    <dbReference type="eggNOG" id="ENOG502RDC6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_584177_0_0_1"/>
    <dbReference type="OMA" id="HIYELTF"/>
    <dbReference type="OrthoDB" id="3650836at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056632">
        <property type="entry name" value="DUF7730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24864">
        <property type="entry name" value="DUF7730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7730" evidence="2">
        <location>
            <begin position="224"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF10157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="468" mass="52478" checksum="8C20B7E66530F032" modified="2013-05-01" version="1">MESSAVPGSSVPAMLPRATQSAQDTETSRPSPAMPQRLFPPVSRRELTGALSSPAMQVKNLLRSNQGALARRVPAIRSELDQKKDLERRVRKRIAPYKNYTEVLPPFSFPEMIVMGIVCSSWNRGVPGLHYWIMQNFGYYRNLAMMYESGYGGERDMRRAANVHLDFASAFSDLDLPIFRPKFQGPREDEEVTYEVFSSGRWAAGPAATVSQFLRPCLLGESDSRSPFRLMDLPAELRLRIYEYALLLPKSGVQVSHKGPGGFAGLHAFSRDYNRPPTRVSAYGPDRGARLPSRLKCPAPAVHLALFAVSKAVYKEAMPVFYGGNLFVCEDVQDLYRLLSKLREHCLHHLRHITFSITKRCKPMATKAFKLLATLPRLKELDIWIHEPSFSTEGNGYVGLSGFLLPGFPQLRRVRGLKAVRFHGDCPTVTSVLGKEMLQPKKEKKKAVVRKREAVSLTGTKAKKAKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M3CD00</accession>
    <name>M3CD00_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_151274</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="4"/>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758413.1">
        <property type="nucleotide sequence ID" value="XM_016906711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CD00"/>
    <dbReference type="STRING" id="692275.M3CD00"/>
    <dbReference type="GeneID" id="27903848"/>
    <dbReference type="eggNOG" id="ENOG502SI3D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028820_1_1_1"/>
    <dbReference type="OMA" id="WDDVGCP"/>
    <dbReference type="OrthoDB" id="77201at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF13">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE EGLC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032669" description="glucan endo-1,3-beta-D-glucosidase" evidence="7">
        <location>
            <begin position="18"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="345"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="363"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF10292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="463" mass="46698" checksum="19FB774CD738BF9D" modified="2013-05-01" version="1">MLSSSLSLLALAGAASAQVRGFNYGALYANSVARQQADFEADFRAAQELPGVGGFTSARLFTMVQGYSTNTVISALPAAISTNTSLLLGIWCSAGQEAFNQELAALRTAISQYGEQLSDSIIGISVGSEDLYRISPTGIENESGPGAGPEQLVSYISQVRDVLSGTVWADKQIGHVDTWTAYVNSSNNALIEALDWVGVDAYPYFETTNPNSIENSPDLFFNAYDATVGAAMGKPVWVTETGWPVTGGQSGQATSGTANAELYWKGVACRLLGSVNTWWYQLNDGAPQDVSFAVIPADRGEPLYDLSCSASGSSSSSAAMSATSMASSGSTSAASVTASGSMLLAPTGTPSARPMSVSGGAGAIATATPDTDTPSDNNQNVGPIASQPAGSGAPMGTGMGGAGYPAPMGTGVSAGSPAVSNGTMPGSYSPSAGPSMPASYTGSAIANAPAVGLLIVGAIMAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M3CEI3</accession>
    <name>M3CEI3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_118749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759577.1">
        <property type="nucleotide sequence ID" value="XM_016901454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CEI3"/>
    <dbReference type="GeneID" id="27898591"/>
    <dbReference type="HOGENOM" id="CLU_2062928_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF11456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="119" mass="12888" checksum="53ABD97F3C744CC5" modified="2013-05-01" version="1">MDAANRRAQEEVFARTKAGRQAGKQAQEANTSEGVQGTRSAHCPGVRVVTTHQHAHAFMGLVSLSWAWFRGSRGHGMTLHGRYGWNVVNVPVAEPGGRVSPGTRLPLMPGTYQQQPFGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>M3CG97</accession>
    <name>M3CG97_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_86165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760944.1">
        <property type="nucleotide sequence ID" value="XM_016910405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CG97"/>
    <dbReference type="GeneID" id="27907542"/>
    <dbReference type="HOGENOM" id="CLU_2591321_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF12823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="80" mass="9273" checksum="BE97AD1EA20FE629" modified="2013-05-01" version="1">MPLFRKRGSLRSVAGRVLSRRTYWQYTISAVTSSMRSLVTKDLRTIGRSLIERLGLEVYVYQRAAIISQIVVIRRRTIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M3CGK9</accession>
    <name>M3CGK9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">OST3_OST6-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_149452</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the OST3/OST6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761034.1">
        <property type="nucleotide sequence ID" value="XM_016905561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CGK9"/>
    <dbReference type="STRING" id="692275.M3CGK9"/>
    <dbReference type="GeneID" id="27902698"/>
    <dbReference type="eggNOG" id="KOG2603">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052855_1_1_1"/>
    <dbReference type="OMA" id="VLFGMYS"/>
    <dbReference type="OrthoDB" id="67566at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000302">
        <property type="entry name" value="Oligosaccharyl transferase subunit (Gamma), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021149">
        <property type="entry name" value="OligosaccharylTrfase_OST3/OST6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12692">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12692:SF0">
        <property type="entry name" value="GH11935P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04756">
        <property type="entry name" value="OST3_OST6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032710" evidence="10">
        <location>
            <begin position="19"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF12913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="324" mass="35762" checksum="CF2DD2EF02B5F888" modified="2013-05-01" version="1">MRLLSLLTTAILPLTALAAKDTGDRFEIASSKPQPARLDDKSYEQLTKAPRDYSVAVLLTALDARFGCQLCNQFQPEWDMLAKSWTKGDKTKESRLVFATLDFLDGKATFQSMMLQTAPVLLLFHPTTGPHANTDKPMERLEFNTGISTAEPVHSWLSRLLPGRPHPPVVRPINYIKIATTTVAVLGGLTFLTVAGPYLLPVIQSRNLWAAISLIAVLLFTSGHMFNHIRKVPYVASNGKGGVSYFSGGFQSQFGMETQIVAAIYGVLSFATISLAIKTPRIVDPRQQKMAVMVWGGIILLVYSFLLSVFRVKNGGYPFWLPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M3CI67</accession>
    <name>M3CI67_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_116533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761619.1">
        <property type="nucleotide sequence ID" value="XM_016901268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CI67"/>
    <dbReference type="GeneID" id="27898405"/>
    <dbReference type="HOGENOM" id="CLU_1939451_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF13498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="130" mass="12973" checksum="6ED971C81938A770" modified="2013-05-01" version="1">MSASTTSSGLPVLTVTVVPGVPIPSLSISNFAYSVTTLSLGFTDAVPIPTTFATSTKPSSATTSAAAAPPPPAPYSAPPPAPYSAPAPTPYSAPAPTQYSDPAPAPYGGHGPFCIKHIFGFPVIVLCSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M3CIR8</accession>
    <name>M3CIR8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Uroporphyrinogen decarboxylase</fullName>
            <ecNumber evidence="4 14">4.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SEPMUDRAFT_125420</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the sequential decarboxylation of four acetate groups of uroporphyrinogen-III (octacarboxyporphyrin) to yield coproporphyrinogen-III (tetracarboxyporphyrin) with the formation of intermediate hepta-, hexa- and penta-carboxylate porphyrinogens in the heme biosynthesis pathway. Acts on a number of porphyrinogens, but only coproporphyrinogen III can ultimately be converted to heme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>uroporphyrinogen I + 4 H(+) = coproporphyrinogen I + 4 CO2</text>
            <dbReference type="Rhea" id="RHEA:31239"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:62626"/>
            <dbReference type="ChEBI" id="CHEBI:62631"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 14">
            <text>uroporphyrinogen III + 4 H(+) = coproporphyrinogen III + 4 CO2</text>
            <dbReference type="Rhea" id="RHEA:19865"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="EC" id="4.1.1.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the uroporphyrinogen decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.37" evidence="4 14"/>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761824.1">
        <property type="nucleotide sequence ID" value="XM_016901984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CIR8"/>
    <dbReference type="STRING" id="692275.M3CIR8"/>
    <dbReference type="GeneID" id="27899121"/>
    <dbReference type="eggNOG" id="KOG2872">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040933_0_0_1"/>
    <dbReference type="OMA" id="LWLMRQA"/>
    <dbReference type="OrthoDB" id="339900at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00717">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.210:FF:000004">
        <property type="entry name" value="Uroporphyrinogen decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00218">
        <property type="entry name" value="URO_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006361">
        <property type="entry name" value="Uroporphyrinogen_deCO2ase_HemE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01464">
        <property type="entry name" value="hemE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21091">
        <property type="entry name" value="METHYLTETRAHYDROFOLATE:HOMOCYSTEINE METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21091:SF169">
        <property type="entry name" value="UROPORPHYRINOGEN DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00906">
        <property type="entry name" value="UROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 14" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="9 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 14" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uroporphyrinogen decarboxylase (URO-D)" evidence="16">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMF13703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="368" mass="41438" checksum="62A88624EE56BC5C" modified="2013-05-01" version="1">MSKHGFAPLKNDLLLRAARGEKVERPPIWVMRQAGRYLPEYHREKGTNDFFECCRSPEIASNLTLQPIDRFEGLIDGAIIFSDILVIPQAMGMEVIMLPEKGPHFPSPLQSPDDEQFKEVMEREVDVVKELGYVYDAITLTRKKLDGRVPLYGFCGAPFTLLCYMVEGGGTKVFRQTKTWIYKYREAAKQLLQKIAELCVEYLAHQVVAGAQIVQVFDSWAGELSPATFKEFSLPYLEWIADHLPKRVQELGEEVVPMVVFAKGAWYALDRLCQTKYNVVGLDWLHDPKEAYAIAQKHGKVVQGNADPGVLYGGHEAITKVVEEMVSGFGGGKQGWIANLGHGITPWVNPDDLKFYFQEIHRLSGSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M3CJH6</accession>
    <name>M3CJH6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_163519</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762064.1">
        <property type="nucleotide sequence ID" value="XM_016908062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CJH6"/>
    <dbReference type="STRING" id="692275.M3CJH6"/>
    <dbReference type="GeneID" id="27905199"/>
    <dbReference type="eggNOG" id="KOG1286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_12_1_1"/>
    <dbReference type="OMA" id="LFKALWY"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004762">
        <property type="entry name" value="Amino_acid_permease_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00913">
        <property type="entry name" value="2A0310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF4">
        <property type="entry name" value="ARGININE PERMEASE CAN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="328"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="384"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="414"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="461"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="490"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="55"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF13943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="551" mass="60141" checksum="36AA2D98765455B7" modified="2013-05-01" version="1">MDVDKIKSADAASPSIRDQDNGPLASRSSSDVEKASSSIQAGETVQLQRKLQSRHLQMIAIGGTIGTGLFIGSGGALATAGPAGSLIAYAFVGTIVYSVMVALGEMATYIPVSGAFTVYAARFVDPSLGFAMGWIYWFSWAMTYALELTASGLIIQYWAPNLNVGIFIGVFWVVITSINFLPVSFYGEVEFWFASIKVLTVIGFLLFGICINAGAGDQGYIGFKYYHHPGAFAEYLVTDNPSLAKFVGFWAVLIQAGFSYQGTELVGIAAGETSNPRKTVPAAIKKTFYRILFFFVFTIFFIGILIPYDNPQLLSSKSDATASPLVIAAQLAGVHSLPGILNAILLCVVLSAANSNVYSGSRILVGLAEEHNAPACFKRTTSKGVPWVGCSVTAAFGLLGFMNLSSSGGEVFNWLLNIVAIAGFISWTCINICHIAFQRALSARGQSRDTLPYKALWQPWFSWYGIFFNTLIILTNGFTAFMPWSVTDFFVAYLSLILFVVLYIGHKVIYRTKFVRAREADLDTGRKEIDELFFEDVEPTTLWGKFWAWMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>M3CMC1</accession>
    <name>M3CMC1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_38757</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF14928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763049.1">
        <property type="nucleotide sequence ID" value="XM_016908717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CMC1"/>
    <dbReference type="GeneID" id="27905854"/>
    <dbReference type="HOGENOM" id="CLU_2948365_0_0_1"/>
    <dbReference type="OrthoDB" id="3341476at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF14928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="60" mass="6614" checksum="BA60A5EA5D5CE384" modified="2013-05-01" version="1" fragment="single">LALNGRFYTALGISPFFAIYGYDIPLPVVLDTGFNETIALAASERAATFIEKIKKITNIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M3CNX6</accession>
    <name>M3CNX6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_161652</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763599.1">
        <property type="nucleotide sequence ID" value="XM_016907949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CNX6"/>
    <dbReference type="STRING" id="692275.M3CNX6"/>
    <dbReference type="GeneID" id="27905086"/>
    <dbReference type="eggNOG" id="ENOG502S8AT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041452_0_0_1"/>
    <dbReference type="OMA" id="YLPDMFL"/>
    <dbReference type="OrthoDB" id="4034134at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038872">
        <property type="entry name" value="Put_GTT3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41807">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41807:SF1">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF15478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="366" mass="39900" checksum="CECE4F6619782784" modified="2013-05-01" version="1">MSHSWLQRHRKAQLLELSEQAGLKQSEDLRKDELVEKLSDYLQSNSTRLSREPAFAAYFGTRSTPGRPTRASNAELIPDSVADVVEEVRSVVKSRGRRPTKVKQESEDEFAISSPVNNLAASPSHAISPLATALSPSGQLNPRTPALRSSARRQTQLPGPPSPAAVAELAEDASRNLVAGFQDLYSVSGIDNQISDIREILSSVTGIHLTVLLLEGIALQTEIFPWKYAFDIPATPITPSRAVLVPDVFILLTSFYWSATLTWALTSILVPLLFAYFYNLTIRDVKRGNVRVAVARYTADPLTYNIVKALATWLVFEKGVTFGVVQPETVDRIQQGILGGSTGMLIGSGIGAIGALYEAAQRRVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>M3CW91</accession>
    <name>M3CW91_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_121192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756528.1">
        <property type="nucleotide sequence ID" value="XM_016901667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CW91"/>
    <dbReference type="GeneID" id="27898804"/>
    <dbReference type="HOGENOM" id="CLU_860975_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF08407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="323" mass="35590" checksum="DDDBB3CA1FFBEF47" modified="2013-05-01" version="1">MAWFTDLFLSTLGYDNKEAFYDGAVLPPTSPPWLTWYYGPLRSSIGHDTLRLSQSKAVQGQKAAVLQSRVRTTVETTPVLRRPVFEYPWGTTHHDNLNRKPSTNPRPGKLPPARDQARTWVETTPVLRRYNDMAAFYDGAVLPPISPPWLTWYNGPLRSTGARHITASPAAIHDQGDCRPPETRHARGSRPRQSFEGARHITASPAASHAPGTQASNTAGQHKAVRNAAVAVASELLKSLGGKIPGFFHQDRHLIFDDADFSGSSSAAQTRDDTSRPSRSTAVRYGPMAFEGACAQPDTGRLRRTRRRVRRRSKTGVFGEVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M3CWI4</accession>
    <name>M3CWI4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_54233</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756608.1">
        <property type="nucleotide sequence ID" value="XM_016909289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CWI4"/>
    <dbReference type="STRING" id="692275.M3CWI4"/>
    <dbReference type="GeneID" id="27906426"/>
    <dbReference type="eggNOG" id="ENOG502SKSW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020425_2_0_1"/>
    <dbReference type="OMA" id="MIHHNSV"/>
    <dbReference type="OrthoDB" id="422736at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22997">
        <property type="entry name" value="GT_LH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36587">
        <property type="entry name" value="EXPRESSION SITE-ASSOCIATED GENE 3 (ESAG3)-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36587:SF2">
        <property type="entry name" value="EXPRESSION SITE-ASSOCIATED GENE 3 (ESAG3)-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF08487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="389" mass="44701" checksum="8EEE40A6B4DEC726" modified="2013-05-01" version="1">MQIGTADCTTDIWFQLPPEVLVSRYHTINKKANQRLRARLGNAYDAEHIRQTIIFGAGKRCAPNQMHTVACYPIPEAPLPDDLYGANTDTVMGKNKYTSLKQRYLNSGYIIGPAKDMRKMFRRAWEKVQAMQDHDPWDNGSGGSDFMYHGSDQSIFNTMWGEQEFQREVMRRRHLSVIDRLRGHSTPKPYYLEGTLVDDPLNPSFTHQPMEHKQGQPDEFGIGVDYFSDLGHQTVNTEDDTQYLIYNQNISAQLQDRDHKLFDCPSRVTGLLPDDILHTSPPLTTHKSWTELPLFTNRCLNTIPVMIHHNGDKGARGWQWPMSWMQGHARREFEMLLGNEESVFAAGRSTGGAFLPSGEYLTFQDLCPREFEWELFRDVEKPEDTPVGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M3CWM9</accession>
    <name>M3CWM9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_152366</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF08076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756197.1">
        <property type="nucleotide sequence ID" value="XM_016907402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CWM9"/>
    <dbReference type="STRING" id="692275.M3CWM9"/>
    <dbReference type="GeneID" id="27904539"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_1"/>
    <dbReference type="OMA" id="KMTRADW"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000374">
        <property type="entry name" value="3-oxoacyl-(Acyl-carrier-protein) reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G02870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639:SF1">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="12"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF08076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="257" mass="27234" checksum="C7C578EDA749462A" modified="2013-05-01" version="1">MAPTQPRTLEGKVAIVTGASRGIGSSIAFDLAARGAKVVITYSSDKSKAGADELISRIQSEANSSAIQVQCDLSQPSAPQKIVEATLAAFGNHIDILVNNAGIISNKFITDITPEHYDSVMNLNTRAPLLMLQAVLPHLRTPGRIINISSIGARAGFPGSSTYCASKAALEGWTRCWAAELGKDGTTVNAVNPGPTESEMLHQVDEALIQPQKDATFIENRVARPQEIAEIVGFLAEERSSWVTGQCISASGGLQLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M3CXC3</accession>
    <name>M3CXC3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NOL1/NOP2/Sun domain family member 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_92875</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a cytidine in rRNA + S-adenosyl-L-methionine = a 5-methylcytidine in rRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61484"/>
            <dbReference type="Rhea" id="RHEA-COMP:15836"/>
            <dbReference type="Rhea" id="RHEA-COMP:15837"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74483"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756878.1">
        <property type="nucleotide sequence ID" value="XM_016910597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CXC3"/>
    <dbReference type="STRING" id="692275.M3CXC3"/>
    <dbReference type="GeneID" id="27907734"/>
    <dbReference type="eggNOG" id="KOG2198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041061_1_0_1"/>
    <dbReference type="OMA" id="RHIIHAH"/>
    <dbReference type="OrthoDB" id="427002at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031167">
        <property type="term" value="P:rRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808:SF3">
        <property type="entry name" value="5-METHYLCYTOSINE RRNA METHYLTRANSFERASE NSUN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808">
        <property type="entry name" value="NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 11 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="12">
        <location>
            <begin position="56"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="147"/>
            <end position="153"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF08757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="398" mass="43909" checksum="0C3CBACB01D3B588" modified="2013-05-01" version="1">MTKTHRKAATSSVDAFDRHYVAIWGEERWQKSLRPALEQPTRYACLLNRYVPLEASKEKLSHPSTEEVPLHLPKASDREATNVLLPNLVARYAKSADGPSSVPSSEPFPAPIPVAGQLYSHWNLDAASSLVAHLLDVQQGENVLDLCAAPGGKSVSLAQNIWAHYHADDSDAKSKALQEKRLQLGTLHSNEADTPRQRRLAENLRAYLPKALFDSQRVVTLRVDGTSPKAHYELVVKTSDGTVNYDKVLVDAPCSSERHIIHAHANARLGGREAPEMANWRPGSSKRLAETQLKLLMTGLRVAKVGATIMYATCSIEPTENDGVIEKMLSQVEKERKKGVKWSVKVGLRAGTGDDVLEAELEKNWAERTKHGWIVLPDHPGGGKWGPLFFAVLTKVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M3CY30</accession>
    <name>M3CY30_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Monooxygenase FAD-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_20295</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757083.1">
        <property type="nucleotide sequence ID" value="XM_016908325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CY30"/>
    <dbReference type="STRING" id="692275.M3CY30"/>
    <dbReference type="GeneID" id="27905462"/>
    <dbReference type="eggNOG" id="ENOG502SM12">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_1_0_1"/>
    <dbReference type="OMA" id="AYCPSAM"/>
    <dbReference type="OrthoDB" id="655030at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051704">
        <property type="entry name" value="FAD_aromatic-hydroxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46865:SF7">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G07040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46865">
        <property type="entry name" value="OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="2"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF08962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="376" mass="40740" checksum="B949623189BD92DD" modified="2013-05-01" version="1" fragment="single">ILIIGGGIAGPVAAYWLAKAGHRATVIERASSLLKSGQGIDIEGPAREIIDRMGLLEQMKARATGEGGFAFTDDDGKPVAAIAGGLTQEIEIMRGDLCEVLCRAVDACDLVEFRYGTKVVELTQTPTHVAVTFDNGEHATFDAVIGADGLRSKTRDLAFDEKTKANAFRARDHYCAYFSLPREDGDSPNSRWQNATGGRIILIRPHNQDVSSAYLSVMEKSDKLAAMCRADKASQKKAIAEEFEGVGGLGPRAVKGMLESDNFYYDSLSQIKLEKWSQDRVALIGDAAYAPSAVTGQGVILSVLGAYVIAGELSENPQDPVAAFEAYEARIRTFVDTQQTISLNGNSPRLANPRSEWGIWALRTSFKMVAWSGIWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M3CYS5</accession>
    <name>M3CYS5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_150943</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF09809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757930.1">
        <property type="nucleotide sequence ID" value="XM_016906490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CYS5"/>
    <dbReference type="GeneID" id="27903627"/>
    <dbReference type="HOGENOM" id="CLU_1807442_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF09809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="143" mass="16589" checksum="9181499539B12EA1" modified="2013-05-01" version="1">MNSFSFFLSATSISFHIFAPQRNNKTTKPPQDMPHIIVACQCPQELHSPGEVKKCKSAGAVLQWESLARQIQRKIKRWFRRREERRKWEKSMSTPYSLDGRRFECTPRPFVSPAPAPYVHHNFDNDALTALPLYTVGCQRRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M3D0T9</accession>
    <name>M3D0T9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Branched-chain-amino-acid aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_151144</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758224.1">
        <property type="nucleotide sequence ID" value="XM_016906629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D0T9"/>
    <dbReference type="STRING" id="692275.M3D0T9"/>
    <dbReference type="GeneID" id="27903766"/>
    <dbReference type="eggNOG" id="KOG0975">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031922_1_0_1"/>
    <dbReference type="OMA" id="VGMNAAY"/>
    <dbReference type="OrthoDB" id="409992at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004084">
        <property type="term" value="F:branched-chain-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009081">
        <property type="term" value="P:branched-chain amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.10.10:FF:000010">
        <property type="entry name" value="Branched-chain amino acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.10:FF:000004">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42825">
        <property type="entry name" value="AMINO ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42825:SF2">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE 3, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="372"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF10103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="383" mass="41613" checksum="42DF1ACC67C743A5" modified="2013-05-01" version="1">MTSSFPPQPVNTIDWDDIGFKVREVNGHIESTYSTKTGEWTAPKFVHDPFLRLHGMAPGLNYGMQCYEGLKASRGPDDKTIGIFRPEANAERMQHSASYVSMPAVPVELFKKSVHLAVSLNAAYVPPHRTGASMYIRPLLFGSSAQLGLDPPEEYTFLVYVMPTGVYHGVHPVACLILEDFDRAAPEGTGSAKIGGNYAPVLRHSGKAKKEGYGITLHLDSRTRTEVDEFSTSGFIGIHGNPDQGCTIVVPDSKNVIKSVTSNTICEIAKSWGWKVEQRPIKYEEIGTFTEVAAAGTAAALVPIKSITMQSKNDTFKYQGGGDEPGPAVIKLLAQLKGIQQGKVKDEFGWVEQVRAYKPEEYVHDGAGEANGTASGQTPNELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M3D273</accession>
    <name>M3D273_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_47793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759348.1">
        <property type="nucleotide sequence ID" value="XM_016909043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D273"/>
    <dbReference type="STRING" id="692275.M3D273"/>
    <dbReference type="GeneID" id="27906180"/>
    <dbReference type="eggNOG" id="ENOG502SA1K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_177926_2_0_1"/>
    <dbReference type="OMA" id="MPLIARR"/>
    <dbReference type="OrthoDB" id="9992270at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40135">
        <property type="entry name" value="MITOCHONDRIAL PHOSPHATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40135:SF1">
        <property type="entry name" value="MITOCHONDRIAL PHOSPHATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF11227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="66" mass="7656" checksum="0810D4F70541E434" modified="2013-05-01" version="1">MPLIARRFSITNFLIATSALGFQVFVLYPWHTKLDDDFSALKKENVRLMQAIEQRLPPPKERSIVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>M3D383</accession>
    <name>M3D383_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_134720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759723.1">
        <property type="nucleotide sequence ID" value="XM_016902656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D383"/>
    <dbReference type="GeneID" id="27899793"/>
    <dbReference type="HOGENOM" id="CLU_748357_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF11602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="370" mass="42343" checksum="03F1EDEF54CBC15E" modified="2013-05-01" version="1">MQLIIGQEGNGDCHLHVSYLTYTSSSGLHHYRAAAFQHQVRYLIIRKHTTNHRTPTSLRGLIFITDMSNAFATSAMRTALELATQATAANGHSLQPPPFPLMQLPKELRDIIYQKMAEDIHIVSVNQRLDYTFLRSHIPILRSSKLLEKDCLRQLLQYAVIELRVRHEGLSGVARNTRCILSPYRRSLFLLHPLRYEVMLVQPVPPLSAMPSNPQGTFSRLKPSHSHRAYYHRAEVMLRTNLRLPLGTIPPRAMMHMDRDPAWYTALSRNQNLYVVFASRAVPAGIYLKRWIQMLEDLQPELRFHYRVRVPSNQQCTCPSGPCLQELQNGSHLRAARGLLRWHCADAIVERELVAIAEAYDIAGCLAFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M3D398</accession>
    <name>M3D398_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prolyl 4-hydroxylase alpha subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_66016</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760826.1">
        <property type="nucleotide sequence ID" value="XM_016909738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D398"/>
    <dbReference type="STRING" id="692275.M3D398"/>
    <dbReference type="GeneID" id="27906875"/>
    <dbReference type="eggNOG" id="KOG1591">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058132_0_1_1"/>
    <dbReference type="OMA" id="GHPGVWH"/>
    <dbReference type="OrthoDB" id="420380at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF246">
        <property type="entry name" value="TRANSMEMBRANE PROLYL 4-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prolyl 4-hydroxylase alpha subunit" evidence="6">
        <location>
            <begin position="23"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF12705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="237" mass="26120" checksum="B7D6EAF2A4FA3860" modified="2013-05-01" version="1">MVAQYAAGCPTQFTKPRVFSQDPLMVYIEDYLSPAEAKYLLHVAEGRWDASPISTRSQIKGYDPEFRSSLTAVLPGDPVVNCVEERAASTLGFLPVSHVEPSQAVKYEISEHFRPHFDWVDGMANPRSYTLFGYLACDGENGEGSCVGGNTQFPNFSGRFPATWCKKFVDCNDESGLGGVAFKPVVGNALYWSNYYPNGTGHPGSYHAGMPVKVGRKIGLNQFGRRDPWDSEAFLDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M3D3P7</accession>
    <name>M3D3P7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aryl-alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_141688</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760961.1">
        <property type="nucleotide sequence ID" value="XM_016902975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D3P7"/>
    <dbReference type="STRING" id="692275.M3D3P7"/>
    <dbReference type="GeneID" id="27900112"/>
    <dbReference type="eggNOG" id="KOG1575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036199_0_0_1"/>
    <dbReference type="OMA" id="YCVFHPM"/>
    <dbReference type="OrthoDB" id="686384at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19101">
        <property type="entry name" value="AKR_unchar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43147:SF2">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43147">
        <property type="entry name" value="PROTEIN TAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="227"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF12840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="542" mass="60494" checksum="1CF50D468963FB7E" modified="2013-05-01" version="1">MAHVNLMTDTIIANLPEEGLRSVLRSMLATDPSITKNLEQRTKVYLTTQSATPKGDLFTQDGTTPAVTPIFLAQQGRIRAMMGCGMCYESIPLLAAIVVQTKDLAISTVDSPEVQQALTAVNGDIIQALTAVQKTLVTSSGLRTLEDSEHLIISSLHQALLEGQQSLSRCGTYAFDRSLVALQASGLLSEAKHNRESEPHEEDRITISALPETVETFKLNGKSLPRLFCGLWQLSSPSWGCAPVTRIRSQFAQYASQGFTAYDMADHYGDAEIIFGNFRASCHNPEALFGATKYCIFTPTTITRQVVQANITERCQRMSASHIDLLQFHWQDYNDPQYITALQYLQEDPRVHSLGLCNFDTSHMLEIISNGTVKIATNQVQFSLIDSRPLSRMAQVCKTHHIKLLTYGTLLGGFLSEKWLDEPEPELFSSTITPSQRKYYEMILNWGSWDLFQELLHILEGIAGKHGVSLSNVATRWVLDFEFVGAVIVGTRWGISDNAEDNLRVYGLHLDEEDRQRIESVLRRSRRDVIVALLGDCGGEYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M3D3Z8</accession>
    <name>M3D3Z8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_117200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760750.1">
        <property type="nucleotide sequence ID" value="XM_016901316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D3Z8"/>
    <dbReference type="GeneID" id="27898453"/>
    <dbReference type="HOGENOM" id="CLU_2470507_0_0_1"/>
    <dbReference type="OMA" id="MEHRERR"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF12629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="88" mass="11110" checksum="594EF8DAD8C01A46" modified="2013-05-01" version="1">MPRRKDKEKEKEKEKEKEKEKEKETEKEEEEEEEKNKEKNKEKNKEKNKEKNKEKNKDKDKEKETKKEKDKDKEKEEEEAYARRRARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M3D412</accession>
    <name>M3D412_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_117462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761041.1">
        <property type="nucleotide sequence ID" value="XM_016901339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D412"/>
    <dbReference type="GeneID" id="27898476"/>
    <dbReference type="HOGENOM" id="CLU_2414694_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF12920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="92" mass="10564" checksum="3D69BFBC9976706B" modified="2013-05-01" version="1">MSWKFATKCEMRSDAIMRLCDATPEQTARDVWVTREQSGLRTQTAFRQHHMTPIYSSKEDEDNDGDNGDEDTKDDEDDTNSFGQKRKAADTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M3D484</accession>
    <name>M3D484_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_108181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EMF12704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016900724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D484"/>
    <dbReference type="STRING" id="692275.M3D484"/>
    <dbReference type="GeneID" id="27897861"/>
    <dbReference type="eggNOG" id="KOG4719">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OMA" id="APAYVWA"/>
    <dbReference type="OrthoDB" id="3776050at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF12704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="214" mass="23147" checksum="BC640525DECF4E88" modified="2013-05-01" version="1">MKYQTAVTVGTLIASAQGAALTKRDAEAAEPAYVWSSSKRDAEVAEPAIIWASSKRDAEAAEPAYVWSSNAEAAEPAYVWSSSKRDAEVAEPAIIWASSKRDAEAAEPAYVWSSSKRDAAEPAYVWSSSKRDAEAAEPAYVWSSSKRDAAEPAYVWSSSKRDAEAAEPAYVWSSSKRDAAEPAYVWSSSKRDAEAAEPAYVWSSSKRDLEASSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M3D4N1</accession>
    <name>M3D4N1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glutation S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_63851</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761296.1">
        <property type="nucleotide sequence ID" value="XM_016909655.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="27906792"/>
    <dbReference type="eggNOG" id="ENOG502S4E5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110291_1_1_1"/>
    <dbReference type="OMA" id="VIFNCIQ"/>
    <dbReference type="OrthoDB" id="410651at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050997">
        <property type="entry name" value="MAPEG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10250:SF26">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MICROSOMAL GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF13175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="156" mass="16933" checksum="5E033FCCADBA37CB" modified="2013-05-01" version="1">MSTTIVVPNQYGYVVATTACTFFLGFWHGMRAGLSRQAAQINAPKAYADSGDMDKAQDKEHMAAMYMFNCKQRAHANYLEMLPATALSLLIAGIQYPMVSTFLGIGWIVGRVMYALGYTNAAQENGRGRVLGFALSQPLAIGLWGLAGWSGIKLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M3D4S0</accession>
    <name>M3D4S0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Solute carrier family 25 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_66300</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760985.1">
        <property type="nucleotide sequence ID" value="XM_016909748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D4S0"/>
    <dbReference type="GeneID" id="27906885"/>
    <dbReference type="eggNOG" id="KOG0762">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_16_1_1"/>
    <dbReference type="OMA" id="WVTATPF"/>
    <dbReference type="OrthoDB" id="193856at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF10">
        <property type="entry name" value="SLC (SOLUTE CARRIER) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="113"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="204"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF12864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="313" mass="34179" checksum="1D6182FBCB47E382" modified="2013-05-01" version="1">MSADFWAGYVSGAIGILIGNPLDIVKTKLQAGSASKATTDRSSSLSQAQRSLSAHDTTPGSLTKWTQFARGAAAPILGYGALNAIMFMTYNRSLSYVQTGNWHTLPQDFTSQPEWWKIWSAGAVGGLATFFVSTPTELVKCRAQISYQSSWKVTQDLWRTTGLRGLYMGGTITAVRDSVGYGFYFWSYELAKRTVVNESDSHTQEALKVLFCGGLAGVVTWASIFPLDVVKTRVQTWDLVGRGDASQPLLGTASQATVTERPGIFKIAQQVYRTEGAGAFFRGLGVCSARAFIVNAVQWAVYEWTMKLLTTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M3D5A1</accession>
    <name>M3D5A1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aha1_N-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_148683</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EMF13350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D5A1"/>
    <dbReference type="STRING" id="692275.M3D5A1"/>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.20">
        <property type="entry name" value="Activator of Hsp90 ATPase Aha1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aha1"/>
    </dbReference>
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        <property type="entry name" value="AHSA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="ASHA1/2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13009">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 HSP90 CO-CHAPERONE AHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13009:SF22">
        <property type="entry name" value="LD43819P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09229">
        <property type="entry name" value="Aha1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01000">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103111">
        <property type="entry name" value="Activator of Hsp90 ATPase, Aha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Activator of Hsp90 ATPase AHSA1-like N-terminal" evidence="3">
        <location>
            <begin position="13"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="78"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="164"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF13350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="345" mass="38767" checksum="DC84BC3488A9C08C" modified="2013-05-01" version="1">MVLHNPNNWHWVNKDVSAWTKDYLEKDLVGIKAEKNGISAEVSKVLSMDGDVDVSQRKGKVITIFDVRLQLEWNGSIPVKEEHENDDGTKEEREGKKDVSGTITVPEVAHDTDEDDYVFEVELYSSSLEKEPAKDLVRKELTPQLRKHFQKLAPALIAEHGKDVQHAPNENPSAKFTPAKTYSNSGVEKSSGTSASSNHTSHNNGSVVNTTSLSDQQEFRTTADQVYEVFTDPQRIAAFTRGTPKVFEGAKAGGKFEIFGGNVSGSYVKLEKPTYLEQKWRLAQWPAGHYSTLKIKFEQNDVDGVTIMRVDWEGVPIGQEEPTKRNWDEYYIRSIKTTFGFGTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M3D5F4</accession>
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        <recommendedName>
            <fullName evidence="3">PLC-like phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_125191</name>
    </gene>
    <organism evidence="1 2">
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016901960.1"/>
    </dbReference>
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    <dbReference type="STRING" id="692275.M3D5F4"/>
    <dbReference type="GeneID" id="27899097"/>
    <dbReference type="eggNOG" id="ENOG502RUV2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="7984201at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF80">
        <property type="entry name" value="PLC-LIKE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26146">
        <property type="entry name" value="PI-PLC_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF13390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="21938" checksum="F7C8CC923774BE83" modified="2013-05-01" version="1" fragment="single">MMFSKSLQPMLCVAATLGAHNSPFLRDATTGFSTSGNQFYNTTTQLAAGVRLVTAQIHHPNDTSSALHVCHADCALLDAGTLESWLAEIKTWMDANTNDVVTILIVNGAGATAGEISAAYVSSGMLPYAYSPTNESANSDWPTLMNEFTYIFENDYDNSSPTDFSCEVNRPTHLANQTATAISQGYMGLVNHFLYENQLFGMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M3D7J4</accession>
    <name>M3D7J4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_39904</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="27905898"/>
    <dbReference type="HOGENOM" id="CLU_183427_0_0_1"/>
    <dbReference type="OrthoDB" id="5372708at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF14155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="57" mass="6947" checksum="AA1157BDF439F087" modified="2013-05-01" version="1" fragment="single">RVCSLLLLNFIDRFRLYRNIRRSITSFYFILANLPFLERNRRTNVIPITLSPYRSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M3D947</accession>
    <name>M3D947_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_82618</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NGG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762530.1">
        <property type="nucleotide sequence ID" value="XM_016910314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D947"/>
    <dbReference type="STRING" id="692275.M3D947"/>
    <dbReference type="GeneID" id="27907451"/>
    <dbReference type="eggNOG" id="KOG4191">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016102_0_0_1"/>
    <dbReference type="OMA" id="DLSHMMA"/>
    <dbReference type="OrthoDB" id="1232at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019340">
        <property type="entry name" value="Histone_AcTrfase_su3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13556:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13556">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10198">
        <property type="entry name" value="Ada3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="269"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="316"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="467"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="22"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="276"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF14409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="557" mass="61992" checksum="2C355189568C0F46" modified="2013-05-01" version="1">MGKRGEVCDRSMRQLVQRRKERVQEEREQEAARDAERARIKREEDRAAKAKKTAAAAKKRQLEADEMDVDGVETERKEVRESLPSVGAHGLARQDGVGVHQGAEAPPSPPVQPGTVAADLMETGTAADDSDSNASRRDVPPTAPLYERIYGKDPTAAEDTLRYHIPEVTDGMSNEEKQDIFRVREWPASDLRELTAGDPPDKDFYNNAKPANQVNFSTFQTYVEPYIRPFTEEDVAFLKERGDRVGPYTMPAFGPKGYKEIWAAEENLSGQGLEAPKQERNEPNEARGSMDDMDDDIADQDTVSMGPVMSRMLSIIRPQPSTSTKKDEGEDANGDTSMTNGDDDAIMALINGTTDEQKPVTYLPGDHPKPDLPKLDYDTLEQRALQEFRYLGIIPPNATPNFDLHEDNEVAARLRTLQHELKIVSRRNNIRKARVLELTEERMAMQEYANISDDLDNQVNAAYLKRNRSLAKPNQKKGAASRPGQKGVASAPAGRGVSDGVRALMQKRKDWIEMVGPVVGFGRPAIPEDDESIFDEATMKRLEKAEKEAEAGEGEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M3D9B5</accession>
    <name>M3D9B5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucan 1,4-alpha-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">1,4-alpha-D-glucan glucohydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Glucan 1,4-alpha-glucosidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_148356</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal (1-&gt;4)-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 15 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762846.1">
        <property type="nucleotide sequence ID" value="XM_016904869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D9B5"/>
    <dbReference type="STRING" id="692275.M3D9B5"/>
    <dbReference type="GeneID" id="27902006"/>
    <dbReference type="eggNOG" id="ENOG502QPM2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012173_2_0_1"/>
    <dbReference type="OMA" id="DHFYTRM"/>
    <dbReference type="OrthoDB" id="6123450at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004339">
        <property type="term" value="F:glucan 1,4-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2440">
        <property type="entry name" value="Carbohydrate binding type-21 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038175">
        <property type="entry name" value="CBM21_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000165">
        <property type="entry name" value="Glucoamylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046966">
        <property type="entry name" value="Glucoamylase_active_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616:SF9">
        <property type="entry name" value="GLUCOAMYLASE, INTRACELLULAR SPORULATION-SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00736">
        <property type="entry name" value="GLHYDRLASE15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00820">
        <property type="entry name" value="GLUCOAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004033162" description="glucan 1,4-alpha-glucosidase" evidence="10">
        <location>
            <begin position="24"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="GH15-like" evidence="11">
        <location>
            <begin position="185"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF14725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="645" mass="69689" checksum="B00CD6289991177B" modified="2013-05-01" version="1">MGPPGGILVHVLTGCMLAATSFAQACDTTTLTTSAPSDSNTNVVLSSFSYCGGVLNTTAYINNLAYNKQVTLYYTDRQGRSTPLASVALSYQNGVENTNFEIWGSSTLAYVDGITQLLNLTYNVVDLGTVYTQSLNQTVVASGEPEPTLAAPPAPYAMPLGFGDDITSWLAASNGSQVTASYSKMFRNIDPNITGAVDGVVVAGRSGPSFESKLPDYEYDWVRDSSLTMEVVQQLYAAATEADAKQAYEDQLFAYAMARAVEQNDPNLQTGLGEPKFYLNNTVFTGPWGRPQNDGPATAAITLMEFAESYMAAGGNQTTVLQKIYDSTTYPNVAPVQKDLLFVARNWTSPSFDLWEEQSSDHFYTRMVQRRALVMGAKFAATVSDNATASTLQEAADALTASLDVFWDVNRGILLYEYGPVLSNKASYLDAAVILALIHGYANDGVYSYTNEQVQSTVVRFVTSFISTYTLANVTQDSSGQVLGVPIGRYPEDIYNGTGTQENGGNPWYLTTAAVAQYFWTASAEYSDAGSMAVTNTSQSFFDYFAPSANLTTGETYSSGSAEFDAVIDSLNGWGDAFMRTAKFYTPADGSLAEEYNRNTGLPQGCEDLTWSYASIITAAIQRASLRNDTAFLQDLANLGFTPNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>M3D9C8</accession>
    <name>M3D9C8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_148362</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762856.1">
        <property type="nucleotide sequence ID" value="XM_016904874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D9C8"/>
    <dbReference type="GeneID" id="27902011"/>
    <dbReference type="HOGENOM" id="CLU_2814053_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF14735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="67" mass="7716" checksum="41EE69B642C85625" modified="2013-05-01" version="1">MLRVSTRMLNEQSEWRPRTTLTHCGSSTVVKLSAVAICPRSGHALPLDMQTTRKRRLMPRQFLITYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M3DA34</accession>
    <name>M3DA34_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carboxypeptidase</fullName>
            <ecNumber evidence="7">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_148367</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="7"/>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762860.1">
        <property type="nucleotide sequence ID" value="XM_016904878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DA34"/>
    <dbReference type="GeneID" id="27902015"/>
    <dbReference type="eggNOG" id="KOG1282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008523_12_3_1"/>
    <dbReference type="OMA" id="LMSTCDF"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000118">
        <property type="entry name" value="Carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF479">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5006527931" description="Carboxypeptidase" evidence="7">
        <location>
            <begin position="23"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF14739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="546" mass="60558" checksum="DABD35C1D8F8C667" modified="2013-05-01" version="1">MKPSCRTAALVLALALAPPALARRDPTIYDRKTNLPHLAKRVPHSSPANAGTVFTSASTPVINQTEAVKRFTVNGSAIPEVDFHIGESYAGLLPIGPGQDVSELYFWFFPTPNPAADDEIVIWLNGGPGCSSLEGVLQENGPFSWQYGTFKPVKNPWTWVNLTNVVYIEQPAGTGFSPQKGTTPATDEIEVAKQFLGFWKNFVDTFGLQNRKVYITGESYAGYYVPYIADAMHNETDSEYYNVESIMFYDPSLTYHVVQGDIPALPFVEHWHNLFNLNQSYMQELTKRHEDCGYKQFMEEAFVFPPTGPLPTPPDVDQQNDTCRIFNDITDAAMLVNPCWDVYQVATTCPLLWDVLGFPGSFDYLPEGASIYFNRTDVQKAINAPIGDWAECSDGVLYADLSPPSALSVLPRVIEKNKKTIIAHAELDMILIKNGSIVAIQNMTWGGAQGFSKGPDQWNDFYIPYHTEFSPSTLAAAGNFGKWHTERGLTFCTVELSGHMVPQYAPSAAYRQLEFLLGRIDNLGEVSDFTTQSGDLGNHNSSMALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M3DAF9</accession>
    <name>M3DAF9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNB-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_148430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762975.1">
        <property type="nucleotide sequence ID" value="XM_016904924.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.M3DAF9"/>
    <dbReference type="GeneID" id="27902061"/>
    <dbReference type="eggNOG" id="KOG2102">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002512_0_1_1"/>
    <dbReference type="OMA" id="WPYFFPR"/>
    <dbReference type="OrthoDB" id="2285229at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056625">
        <property type="entry name" value="SH3_CYT4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056624">
        <property type="entry name" value="WH_CYT4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF65">
        <property type="entry name" value="EXORIBONUCLEASE CYT-4, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23214">
        <property type="entry name" value="SH3_CYT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23216">
        <property type="entry name" value="WHD_CYT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNB" evidence="3">
        <location>
            <begin position="863"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="361"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="212"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="246"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF14854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1402" mass="158240" checksum="856ED9DCCA3002E4" modified="2013-05-01" version="1">MLTSRHGALGQTSGKATAWVCLSCRTKRHRRGQHTVADTNTTTDVVDGHGRPIVRRHMIGNRIKRPRVETHSWEKAKIGIPAVEYAEKIACLDIKSFAEHVHPSIGQELQIKFSKGRRLKAKVRDHKVAEGARRYDWTVGPKPSAFRKGSWMSINHEGFKFDIEAASDESIQRASGTGKGKGPASQELAFEQSDGSFLARKKLHNSRVGRHSEELLMAIDEQKSAIQDMEAARKNERAQVAANQESTVSSAAATARPTSSENDFAEQRILDRSSWGNIAVYQNPNHDFLGLVSRQCAQHANDKQKPCPALPRLSSYNLSRTWPMQSNVRHIFAWQTAQPAQQLRAYHSSHTHDLQVAPAESLDSFERSSANVDASTKPPDPISEKRGGIRAQLRQWQELHGREELMPDLPPEDDGPIDFETPYNSLTRLPNAQSMNQEAEKASEENDRIAFFSDNKEGFEGTSKEQSRFLEPGDLVELEFLHTERESVMAIYVRRVAKGTGQFLTLNGRWQHVNEGAIPFSVPGWINPKMLEPLLKYLPDPQNEADLKQLRLQSKTEDLDVPREVSSHLVARLQEFADEVRELYRRNASALDDAHNLLAHETDLRYGSVVSAAATLLNMPVSKLPLAALFTVRKALANGGFGFNIDRRSHRLTGYMQIRSKEQVRMVEQVRVWIRQWQEDSALKASMDAERARKYRSTKGAQIMYSFLEKSRRIIQRQRQNRDAVPESGNVGPSKTRLSLQMHKETVSVEMGNEFTEEESQIVKFIEAWCCSNMFLGLTRIESLPPLILHALGVYPDSDLKMSIGYLFLQELGTIVPYENRVRFDQYLLLPSSQHSKPLQKLMTAVLGMRETPNFYDSMSDLRHDWKDLPVYCIDDASAKEIDDGLSIEDAGVGADGKQQHWMHIHIANPTAFFSRDHPLAKMARHMGETLYMPERTYMMLPQWSTARHFSLAPNRPCLTFSAKIDCDGHLLETKVRPGIIRNVFRVTYDEIQEVLGDGGRHVQPEKIILTVGGAPPPSRDHISDAGILADGNLSDIRKLRDLALARSAIRRRAGGIFFEQHHPDMRVWQGTRSPGLAWDHPHRKGSRTIRGDPIIQMQSQRLVNYFTASRENSQVLVSEAMLLCSEIAARYCADRNIPIIYRGTVDIALPGDEQPKEQQWKDFLAQGKDLPMHLGLPYLHSFGHTVLRTRPLKHAYLGMDYYAKVTSPLRRYGDMILHWQIEAALRYEASSGQSLLAQANDKNAKHDRTFLPFSTSALETIMVGLQPRETMITRAKRYSNDFWAAMLLFRMFHYKEGGAGPVPTSTDVSFAGALPPGEGGFPYETLTVFLPNSPDGARHDTLGGICLEMSVGVEMMKPGYVDSGMEQPMQGDVWEVGLERVDVYLRKIVCRPKRLVGRDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M3DB14</accession>
    <name>M3DB14_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_147185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763386.1">
        <property type="nucleotide sequence ID" value="XM_016904136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DB14"/>
    <dbReference type="GeneID" id="27901273"/>
    <dbReference type="HOGENOM" id="CLU_1058330_0_0_1"/>
    <dbReference type="OrthoDB" id="9986861at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF15265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="263" mass="28587" checksum="83CB4DF9CE2F6D54" modified="2013-05-01" version="1">MDEPPCSPTDVPQRSETPRPPAAAAAAATQSNHPQDPSTPSRRSNHHPHKPHKPNPPTRQRSLTEVLHALDLLHQTSQPVLLIGLDPSWLSLNRPSSQRNAHSSSSSSSGSSSPSQYSTFQTTFTQLQQNNPSLYMELHLLHPDSRENIYDVKRKIRDGSGPEGGSCDWTAVLWDSILRSDAELTGLFEDLVNFVREMLPAAKLVFPRDDADFAEALRRNLGVFVEGGVGGGAGAGAVSSPTLPPPSEKLTRSALETMQGFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M3DB73</accession>
    <name>M3DB73_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_147065</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DIF1/spd1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763220.1">
        <property type="nucleotide sequence ID" value="XM_016904062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DB73"/>
    <dbReference type="GeneID" id="27901199"/>
    <dbReference type="eggNOG" id="ENOG502S8VH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050885_3_0_1"/>
    <dbReference type="OMA" id="PFCGINR"/>
    <dbReference type="OrthoDB" id="4072855at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990846">
        <property type="term" value="F:ribonucleoside-diphosphate reductase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013900">
        <property type="entry name" value="RNR_inhibitor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28081:SF1">
        <property type="entry name" value="DAMAGE-REGULATED IMPORT FACILITATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28081">
        <property type="entry name" value="DAMAGE-REGULATED IMPORT FACILITATOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08591">
        <property type="entry name" value="RNR_inhib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="141"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="183"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF15099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="231" mass="25424" checksum="D4849B7C8F88BE0B" modified="2013-05-01" version="1">MPSEHRAKRQYQPSNQTTLTSFFSRTTNTPSPSLDHETQSSLLNVGMRVRKSVPEGYKTHKTLGSPAFPFPSSAPSRAQAVSATTIQPSARTMSSTMSSRELVPFCGLHKTGGIEVPASSAPAAMQHDYDEDMPELYMSQSTTSTQHAFYGSSSQSASNKKRGYEDEAEDDMDSFFHEGDAISEELDAMRPTARIKSSSTRKPGSDHLHIVGDDDFEEAPFLVPMDVEEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M3DBP3</accession>
    <name>M3DBP3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Isopenicillin N synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_114565</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763591.1">
        <property type="nucleotide sequence ID" value="XM_016901098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DBP3"/>
    <dbReference type="STRING" id="692275.M3DBP3"/>
    <dbReference type="GeneID" id="27898235"/>
    <dbReference type="eggNOG" id="KOG0143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010119_6_3_1"/>
    <dbReference type="OMA" id="AKYEVVT"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="192"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF15470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="353" mass="38996" checksum="2E13A8D84A0BBB2E" modified="2013-05-01" version="1">MAEFTSFSGRKRPLAGDAVRKAEFHEIPTISLAASEQDIIEQLRDACTRVGFFYIKDHGVSSEVIDGIFRTAETFFNQPLETKAEIHYKKSRVLHGYEPISEVLTDESKRADLNEAFNCGYEPDLDPAGHNCTSPAGDGPMEGPNAWPSMPGFKENVAAYYGQILELARRMVRLFAKVLGLPEGYFDAAVRRPGAMLRLLKYPAQDPQDPLALGIGAHTDIEAFTILCQGTQPALQILNVDGQWIQAPPIPGTFVVNIGDMLARWSNDVFISTVHRVHNCTGRERYSVPFFFGPAYDTVLHPLPTCVSEDGKGGYEPIVAGDYVWQRLAQSRLSSAEKEIREPTTTTAAKISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M3DC33</accession>
    <name>M3DC33_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HOOK N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_37833</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763741.1">
        <property type="nucleotide sequence ID" value="XM_016908682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DC33"/>
    <dbReference type="STRING" id="692275.M3DC33"/>
    <dbReference type="GeneID" id="27905819"/>
    <dbReference type="eggNOG" id="ENOG502QQM8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013811_2_1_1"/>
    <dbReference type="OMA" id="RDVCNGQ"/>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030705">
        <property type="term" value="P:cytoskeleton-dependent intracellular transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22211">
        <property type="entry name" value="HkD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043936">
        <property type="entry name" value="HOOK_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947:SF28">
        <property type="entry name" value="GIRDIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947">
        <property type="entry name" value="HOOK PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19047">
        <property type="entry name" value="HOOK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116907">
        <property type="entry name" value="Hook domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HOOK N-terminal" evidence="6">
        <location>
            <begin position="11"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="158"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="201"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF19047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF15620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="438" mass="49747" checksum="C4484D2B78DFFD01" modified="2013-05-01" version="1" fragment="single">MAALASDSLGESLLAWVRSFEGGGRVDQLGSLNDGTVLWAILQDVDPDYFAGSLPEPDIEQSSEWTRKWQNLKQLERQLSVYYRDVCNGQDAAGTSNGPDLKAIASESSIPHLERLIMEIIRAAMASPASNQRMGKRLLGLGNEHAMAIAYEIRNMQDAEAPESESASRDGSAYHSEQELPERSVAAKKTRQNGGLFGDPMLEKEEELLQAQATIEKLQASHAAAQRQLQDLKQAKEQLQEAFDTYRSEINARGRPAVADDDLKKLQRQADNDRAYIDDLEAQLQTSRNAVDDYERQIQRFKDEHEAGQKLRDDLQVLRAENEDLNQKVKANENLKKKIHALQEQDKANSSLREELKLANERLEELERLKQVQAGLEKEIIEKKGLIRNQEYQINELTTTRKHAEYDARVLAQKLEAARERQERDHEAIEELRNKLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M3DD81</accession>
    <name>M3DD81_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nucleoporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_147576</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NUP186/NUP192/NUP205 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763905.1">
        <property type="nucleotide sequence ID" value="XM_016904390.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.M3DD81"/>
    <dbReference type="GeneID" id="27901527"/>
    <dbReference type="eggNOG" id="KOG1835">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002778_0_0_1"/>
    <dbReference type="OMA" id="WSQMFAE"/>
    <dbReference type="OrthoDB" id="2019644at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021827">
        <property type="entry name" value="Nup186/Nup192/Nup205"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11894">
        <property type="entry name" value="Nup192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF15784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1659" mass="181579" checksum="D9F5DBE3CF62A14A" modified="2013-05-01" version="1">MATEDPLLRLQILQRDLVATTDSQIKNIERLSEQLDASVKDLEELLRRTKKNDASRAIIKQGAGSAAHATESNLTIGDVTYRVQDAFREAAIAVADELDLDELEAATLCILSQVESCETDPSLPLRAMVRFHEQRATLLDCMRLLLQLGIDSDVAPDEDYSDAFSEIGRKIVEGRGQKGNEDRRPDPAAYWRSCVDGLTDVEGFLKKMAEYKDKLVVTGQHASGDVGDALRAQRFLLTRQHESLAAIMCYLLRGNFVQPEDYRIFLSKASTLETEIDITIHYLPILISGASQMGSEGLTGGETAHDLHRLFAAGNSQLQWKQPMLRAAATVCWLAEYSARFAGPSNGLRQSAAEAKADEDARAKLFFDALEAKAFHFMLAAAAFLKPVAWYDPARTGIVDFLVDGAVTVVEMPRASNDFSALTMRELQAFTDAFVTHMPDCLRKLKLDEDEMRRNLLSLSGTGPAHSELDLERFMVIMACAYQDDTDAAHDFWADKESNLYGFLRWVSVRLPTPRVAAFCQLLRSIASDDKSADQAHRFLLEDVAMASGKLRKTYAVSWTQIFSELELYASGLRNRPAPIPAPGQNSSTVEDNFEEPETGIMLDSYLGLASHICRTSPDARNWLLKDQPFHLGEVMFQLARTATISRVRACCLDLLAALLTDKVPEVRNGMWVLLDSWISSGGLDGSNLPRVQPRVQYPAKQYLQAYANNAEAGASLLTLLNALISPFPSTLDLPIDSLPFPETLGVPHRHAGMDIYVDFVMDAVLARKVPRMPMDGESSLLDFVRYECLHFVHQCLSSFNEDLVLLANTTTVGVESAMETKSLATYVRLHPFARVMEWLFDKAVVGSIFATIQQNLDTLDHAESGSPLVRAVFKGLQVLRLAWKLQPIYFDVVRPLMAEATSKAQPVTSSTLTSIDDAFLCHLDAVADVAQFTASKHVDISLECTALLQQIGSSRKLCESRETGVARSSGSSRLIGLLAPIGEDLTVGLQPMFELLEWDLETDGVPAKMVKAKAVLDSMRASLDTANGKPCLAHCLLGFHCYERAVDVPARSVFASGKSLFHAIATCAVNLPVASGETGFRSWLLDVKRGCLELILKLATSPLTARIIQPELRSMDFLAALSRSEIPVTVHSVWDSLATIEPGALLDTAAVAIRNFMHIRASFFEFAAFDLRVAAEQKAFSVQERIVSSLLGSIKLPTGEELPTASIFELFDFFDLETAPALEPNYSKCMFFGDIDLSSCTKNDPDTLTAFDLNLAHELLILRKRELTENGTIGNQTDMDGASDEIAAILASLTSQNNWRAIHAARITALEAWTELLSLVITKGGLDDAATLPLSLQGLLLVLPKYEKSLGDDLEAAGLLAKLVLTFTYAISPASRDASQQAANVASERLLTIFRISLKVLTDSSTDAALRDVAYRTCCAVLGTWSSKTVVASAKQLLQLVQNAGDRLLTVVTEDAFSGRGITRVSALLFLDGLISLRQGLKLITPMLRALLKLNFIPVLIDMSIGSVSAAFHAADETAATLAYFHTALALLLRLCQTADGAQLVLNSGFFNAVDESKLFSTDPDLGLDIDNPAALEEFYSILADVLRVIVAAVVSKGPQPGTAFLQQHRYTVQAIFKQAARGQATKVADELSRLILATEFLEEDEATLAGAPRNGFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M3DDF1</accession>
    <name>M3DDF1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_131455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763970.1">
        <property type="nucleotide sequence ID" value="XM_016902425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DDF1"/>
    <dbReference type="STRING" id="692275.M3DDF1"/>
    <dbReference type="GeneID" id="27899562"/>
    <dbReference type="eggNOG" id="ENOG502RV5Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_413982_0_0_1"/>
    <dbReference type="OMA" id="KRGHDDH"/>
    <dbReference type="OrthoDB" id="5411141at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="593"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="627"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF15849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="663" mass="72338" checksum="366EFD64C6353DC8" modified="2013-05-01" version="1">MEIRQRQDDQFRSNQQQGQGNQNSNQQQGQNNQGQQQQQGQNQQQGQPQQQGQNNNNNNNQQQQQGQNQQQGQNQQQGQNNNNNQQQQQGQNQQQGQNQQQGQNNNNQQQQGQSNQGQNQQQGQNNNNNQQQGQNNQGQNNQGQNNQGQNNQGQNNQGQNQQQGQNQQQGQNQQQGQNNNNNNNQQGQNNQGQQQQGQNQQQGQNQQQGQNNNNNNNNQQQQQQQGQNNNNNQQQQGQGDRGQNQNGNQQSNGNSQSQGQDGDRGNDNNSNDRGNGGSQSQGQNGNNDNDRGNQGQNGGNDGNRGNNGSQSSQQGQQNGNNQYGGNGNSQNGEQQSVDSGKTAIISGSAAGAVVIIVVIVFIWWRRRRGATYGDIARFRRHTPTVVPEQHHESGFAAMPVYRNNTYSVHRSPADALRNVSEPPEMTTLAPPAVTVPETSPHRGSVTESTLWKSANPPLPSPEERGWPLTDTATAVIANQPPRYELSRSKSGTGLVCKKTADATSSGDNTPTANSPVESHRGGRWSWTNSQAPSTPRAAAPNARASLTSLTSRHFANLMRGHATPKEDTSKGTGAPKTALKNHATTPVLAPPRVGRKMSQKSKLGHQPRVGNLSMISKPLGPAINSPDEAHSPLSTKEDTSRESSSTAAISPVIETRPQHYRWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M3DEK8</accession>
    <name>M3DEK8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4211 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_38938</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">SO2202</strain>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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    </evidence>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF09741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="286" mass="32037" checksum="ADF1F4F60C8F889B" modified="2013-06-26" version="1">MHQDQQSSMHLKACNRIAAPVIKQRLQAISGRVGETHSKLIEDCFRRGDSFELDPTILCRRLLRLNMAAIHTTSISITNVLLDLYTLPDASVVVEGLRGECKRVLSAHEGVWSKAAIGELHRVDSTIKESMRLRSFGLIGTNRVVTYENSIRFGDGTPIPAGVRIATPIDAIYRNSQFYRAPDDFYTFRFSEQIETKVTLVLTKKHHDTCGDSAAGGILANREHALVTTSDTFLVFGYGRHEMKLMLAHVVMHYDLRIEGPRPKNTDLGIASLPSQKVKIQIRKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1QE93</accession>
    <name>N1QE93_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_158482</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757353.1">
        <property type="nucleotide sequence ID" value="XM_016907794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QE93"/>
    <dbReference type="STRING" id="692275.N1QE93"/>
    <dbReference type="GeneID" id="27904931"/>
    <dbReference type="eggNOG" id="ENOG502T1WN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_452817_0_0_1"/>
    <dbReference type="OrthoDB" id="3639052at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="530"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="562"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF09232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="603" mass="68635" checksum="6106E712A4FED243" modified="2013-06-26" version="1">MEVASGSDEDIEPEVSEPRSHIVPTEPRQTREHVRFRQSERSESENELRETREHVVFRERDPINSEDEPPQTTDYVVYRERVRSNSENEPRQTREHVVVERERSDSKNEPRAHRGHRERSQRTRPVGPTERIEQFYGNQRMTPGLRPSVNMRSSNHQRIGSKPEPLESSDRKPARSGKPGFEELHMSAARKPGLEPRISHVQTTGDRRRRSSRLYATSSQAASPGNLGLDQNANEMLDDYYDGFDDNDLPNTTSMGLHNQYGPGHALSDFNLGKPPPRPHNPFAEAVHVSFNDQVVPMSFNQPPQPPPPRPPRPTGFSGSPPPGRPEGISSGALVRPSKRSDYIIRAPYQTAIWDRAAVWNQVEQKYDLQLKLVLTRHGERYSSDNFPYRSGTWTDIVFAHKLNEQYHSLKTAKVGILQKLTAYKKISFVYFIQFHAFPDVRYPSTGAWLRTDRKPITFRDNPMTRNSFMNQLRRLCTKRSILYSTLTGAPRDPPDERPQIRWVSRLDDLIEPGAVIDIDVKETFDSMTIYAGLFFAIILSFASALGYGFAMQGDFSTGFSLASWMITALGFFAAVVAAGEYIGLDSPKATLMDADGRERPWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1QED9</accession>
    <name>N1QED9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_119294</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758887.1">
        <property type="nucleotide sequence ID" value="XM_016901496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QED9"/>
    <dbReference type="STRING" id="692275.N1QED9"/>
    <dbReference type="GeneID" id="27898633"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_0_0_1"/>
    <dbReference type="OMA" id="FVARPHC"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053212">
        <property type="entry name" value="DHP_3-monooxygenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054707">
        <property type="entry name" value="DhpH_subs-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47469">
        <property type="entry name" value="MONOOXYGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47469:SF2">
        <property type="entry name" value="OS06G0597600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22607">
        <property type="entry name" value="FAD_binding-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="7"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="2,6-dihydroxypyridine 3-monooxygenase substrate binding" evidence="5">
        <location>
            <begin position="195"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF10766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="437" mass="49595" checksum="A07AB2374A717426" modified="2013-06-26" version="1">MHHAKPHVVIIGGSLGGLFAGVALKSHGYNTTILERTPQYLLDNQGAGIVAGGDTIEFFKRYDRTGKPVAVPSYKRIYLNRQGETIYENEQRQNMTSWDLAYYLLRANYDRVDSAYLKGYQLPEERASDGTIEYRYGCTVTEVVDEGPHVRVKFIKKNEDGSQVEEELTTAFLVAADGPSSTVRRMFYPEIERKYAGYVVIRGTVPETQASQSALDVFRERFCFYHTEGIQNLTYTIAGENGSTEVGERLLNFVWYSNFPEGEPELEQVMTDKDGRRRRITIPPGMIDPQAWEMIKSRGRDRLPPQMAEMVEKATTPFVQCITDVASPKPLYMSDKVCFVGDALFGFRPHTVASTSQAAFDVMSMVDWLDGKIDRKQFVAQVMTYGRLIQSRGISIGDRSQFETLPIDSYIEDRNLMSIPRTSLEYPEWTKEGLAEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1QEQ3</accession>
    <name>N1QEQ3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_70497</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759046.1">
        <property type="nucleotide sequence ID" value="XM_016909907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QEQ3"/>
    <dbReference type="GeneID" id="27907044"/>
    <dbReference type="eggNOG" id="ENOG502T9JP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2238752_0_0_1"/>
    <dbReference type="OMA" id="MAKDQIN"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF10925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="108" mass="11192" checksum="BE862F8B9C3A46BE" modified="2013-06-26" version="1">MPSATVIAGTVFALIAVFAGYIYLVGIPPEMKRKLEKQALRTMGENKASYMFKSQLDAVPDGPGGPGSEELKDVKKGLGDIGGSALQNPLGEAAGEGADEATRPLTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1QEZ9</accession>
    <name>N1QEZ9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_86986</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759894.1">
        <property type="nucleotide sequence ID" value="XM_016910428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QEZ9"/>
    <dbReference type="STRING" id="692275.N1QEZ9"/>
    <dbReference type="GeneID" id="27907565"/>
    <dbReference type="eggNOG" id="KOG0032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1283229_0_0_1"/>
    <dbReference type="OMA" id="CYHAPED"/>
    <dbReference type="OrthoDB" id="310217at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF13">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF11773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="211" mass="23413" checksum="07D2B3A6900A7AF7" modified="2013-06-26" version="1">MEALAFIHHGLRYAGKGTFTRDDYHGAIIHGDLKEENFLLTWTFQPLPQLKLADFGAARLAGSRDGRILPGTDCYHAPEDAAIYGDLKPRAVSSRLWQEMINRRTIASDIYAFGLMVHMFACGERNPIKIGTDPSTLRIPEEYGTSGLLELLQKMLAVDPADRAVASFDGEHGVMGEINKMRDARDRLISARQLPGPAEWAFRAPKGHHAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFD6</accession>
    <name>N1QFD6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">COPI associated</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_151302</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757299.1">
        <property type="nucleotide sequence ID" value="XM_016906731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QFD6"/>
    <dbReference type="GeneID" id="27903868"/>
    <dbReference type="eggNOG" id="ENOG502S6ZT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120579_0_0_1"/>
    <dbReference type="OMA" id="MDYSDAF"/>
    <dbReference type="OrthoDB" id="423534at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013714">
        <property type="entry name" value="Golgi_TVP15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28128">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28128:SF1">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08507">
        <property type="entry name" value="COPI_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF09178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="131" mass="14524" checksum="2DF7FCA21FE21CFA" modified="2013-06-26" version="1">MDFSDIFRIVNLVVGVLMILGGIGQFWPSFSVQAIIIAVYLWIFGLATAALEFQIPPQVARYASFMFSFIGRGIFYVFMGCIVMGDKWWKYLDGALVVLVGIGYIALEFVPSIEPPANMRDADAGWGAEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFQ7</accession>
    <name>N1QFQ7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thiamine-binding protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_143240</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0045 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758703.1">
        <property type="nucleotide sequence ID" value="XM_016903035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QFQ7"/>
    <dbReference type="GeneID" id="27900172"/>
    <dbReference type="eggNOG" id="ENOG502S45I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137479_0_0_1"/>
    <dbReference type="OMA" id="RVIGQCH"/>
    <dbReference type="OrthoDB" id="5587367at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029756">
        <property type="entry name" value="MTH1187/YkoF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002767">
        <property type="entry name" value="Thiamine_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051614">
        <property type="entry name" value="UPF0045_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00106">
        <property type="entry name" value="MTH1187 family thiamine-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33777">
        <property type="entry name" value="UPF0045 PROTEIN ECM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33777:SF1">
        <property type="entry name" value="UPF0045 PROTEIN ECM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01910">
        <property type="entry name" value="Thiamine_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89957">
        <property type="entry name" value="MTH1187/YkoF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiamine-binding protein" evidence="3">
        <location>
            <begin position="17"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF10582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="134" mass="14712" checksum="BD90031F948B0DC6" modified="2013-06-26" version="1">MADDQPEKLPTPASCTADFCLIPLGTPTASVSQEIAAVQRLLKKTGIKYSMHSAGTTLEGSWDECMKVIGQCHAFLHARGVVRIQSDIRVGSRTDKKQGFEDKVKAVERLLAEDDDDNNNKNDGEDDEGITYTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFT8</accession>
    <name>N1QFT8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme E2 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_149885</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760243.1">
        <property type="nucleotide sequence ID" value="XM_016905832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QFT8"/>
    <dbReference type="STRING" id="692275.N1QFT8"/>
    <dbReference type="GeneID" id="27902969"/>
    <dbReference type="eggNOG" id="KOG0425">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030988_1_1_1"/>
    <dbReference type="OMA" id="FQAHIKF"/>
    <dbReference type="OrthoDB" id="19692at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010828">
        <property type="term" value="P:positive regulation of D-glucose transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051865">
        <property type="term" value="P:protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd23811">
        <property type="entry name" value="UBCc_ScCDC34-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000051">
        <property type="entry name" value="ubiquitin-conjugating enzyme E2 R2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="10">
        <location>
            <begin position="2"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="145"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="173"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="189"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF12122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="219" mass="25093" checksum="34FB5B0A820B7373" modified="2013-06-26" version="1">MAAERALMTEFKSLSKETWTEISLINDNIFEWSVALIVLNPDSIYYGGYYKARMTFSKNYPYEPPTFAFTRPLWHPNVYVDGRLCISILHSPGEDLMSGEDAGERWSPVQRVESVLISVLSLLDDAECSSPANVDAGVQLRQDPEGYKRRVAADRENSKQDIPEGFQMPTHETAFKKEEVEKDMSWSDSEVEDDFDDDSDDDEEMFDENEGTDEEEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFW2</accession>
    <name>N1QFW2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_118095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760273.1">
        <property type="nucleotide sequence ID" value="XM_016901402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QFW2"/>
    <dbReference type="STRING" id="692275.N1QFW2"/>
    <dbReference type="GeneID" id="27898539"/>
    <dbReference type="eggNOG" id="ENOG502SGGC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1171248_0_0_1"/>
    <dbReference type="OrthoDB" id="4525115at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF12152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="237" mass="25728" checksum="6DA75084DCA0F9CF" modified="2013-06-26" version="1">MPIGQAVGNKITWTDSADKKLLMAMLEVASPSVPNMVEVANVFGEGATPKALRHTRARGRDFKSPPHENFKAHHNLPAYTPTQKVTQATMPSGLSEGNKIVWDDAADRQFLMAIIKAAAPTLPKFADVAAIIGNGVTASALSNRWAKLKKQIEGTGEGRSSAAPSTPSKPKSTPSKAKGTPRSARKRKAKDMSENGDDEEEMEEKAGEDEKAPSEKKVKIKEQPLDEDEDEKEEWLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGP4</accession>
    <name>N1QGP4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_152623</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
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    <dbReference type="GeneID" id="27904612"/>
    <dbReference type="eggNOG" id="ENOG502SEWH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087328_0_0_1"/>
    <dbReference type="OMA" id="QFDPRRN"/>
    <dbReference type="OrthoDB" id="4085451at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054448">
        <property type="entry name" value="HTH_put_ascomycetes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22943">
        <property type="entry name" value="HTH_68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helix-turn-helix" evidence="2">
        <location>
            <begin position="164"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF16396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="222" mass="23654" checksum="8E51F1B57D9871AB" modified="2013-06-26" version="1">MYLPLHCPLKIDQESLGMGSASSKAAKTAGSAARKYPARSPLASATTNTPAPPPPPSFAPQQPGPTVRPAPSASGERDAAINLDASDPDFAQSLRNLGPVQPNPTLSPTSAFNQSHSSSSTTRQPDPRLNPAVLVLSARADLASRADAEIAETGRRGRENKREFLDVYTIRQILTLREQGRSGEAIEKHLSLKKGVVERLGVEGVFGLIQESGRAEKEVRMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1QH60</accession>
    <name>N1QH60_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_145783</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EMF16556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016903265.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.N1QH60"/>
    <dbReference type="GeneID" id="27900402"/>
    <dbReference type="eggNOG" id="KOG2208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003293_0_0_1"/>
    <dbReference type="OMA" id="DHAGQQV"/>
    <dbReference type="OrthoDB" id="10027144at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00105">
        <property type="entry name" value="KH-I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd22449">
        <property type="entry name" value="KH-I_ScSCP160_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22450">
        <property type="entry name" value="KH-I_ScSCP160_rpt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22408">
        <property type="entry name" value="KH-I_Vigilin_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02394">
        <property type="entry name" value="KH-I_Vigilin_rpt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054548">
        <property type="entry name" value="SCP160-like_KH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22952">
        <property type="entry name" value="KH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="228"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="310"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="404"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="729"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="796"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="887"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="964"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="1045"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="1117"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="1234"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1084"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1150"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1084"/>
            <end position="1097"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMF16556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1307" mass="142464" checksum="BC412041257DA297" modified="2013-06-26" version="1">MATTTNGNSNAATEGMSAAERLMQAHNVTIEDAVDEDLPVPAASSSDAASGAVSGSEPSSNGTGIKAAGKQPVRDAPAPAASSNRPALDTQSEELFPSLGASKAPTTGSSMWSKKPAAIGKANGTATAGKPVNAASRSAAPSAGFQSGSGLVNLPGRNSESIVLPLSEMKPRKELKKPVADILRDINKRSKASVVMKPGTNGAFVFEGTGPIDAVRSALKEVAGELYAKKSEKVPVPMSVRGRIVGKQGATIQAISKRSGARINISKQEAAEILEDDDMDASVDVMIEGDPMSVSLAKQEIEKIVNEHSSSVSSRLRNVPPEYYPFLAARDNQRLHDLQQGRDLRINIPQYHVWKDSLPDASVDRQPAAFKPQTGLPIQLAGDRYAIAEAKAEIERQVRELEQKLTLEHISVEKGRHQFIVGEKGKALHDFLQETGCSVILPPDGNDSETLAVIGPADKIEEATNRVLELASSMAMASADIARAHSGAPRGANVHAREITRYLQQRSALQDLERVHDARIVPDSTGAWQIYARDGKNAIKARADIMNLVAGHPPSRFQSVQVDPFYHQHIRENAAPQIRERHGVRVVMPNELSDEPVLLVFEGRVPSPDYQLPRGVPQAQQVQAFGQALQQAQQEIDALLKGRPDIVSRQVDAPAKFHDKIRRHIDQHHQGLAAGQLPVQVSYGGQRQAETRRTPEPNLDLRGPADSVETLLASLLPFIEQEHKDELERDFKLSFEFPQKHANHLIGRKGEHINGLREKFDVDIQLNDGQCEIKGPQAKANLCKSHILGLVKKLDDEKTHHLNIPQEFHKDLIGAQGSQVNRLQERYGVRVQFPRNKLGTEDEPAVTEGTNRRETQKAYEVIVKGPSKGADGCREELLSLLEYVKDNSHSAVVSVAQNQLPSLIGAGGKEMDALRLETGAQIDVPSARDAAGPEGRVDIKIRGSKRAVDEAKKLVQEKAKVFDNTVTRVLDVERRHHRHIIGPQGSHLRNLIVQAGGPEDTRLHNRMIRFPKSDAEGNEIRVEGQKAVVDKICAAIQAVVAEHESQTTEILEVKPDKHRLLIGRGGETRRHMEQQFNVSINIPRQSETGPQRSQVRITGQPAEVQKAKEHIVEITKDLEGETVGVPRKLHHIIADNGQFFRRLRNDHKVTVDHDGQRPPPKQAMPAPSRANGAGAMPLITDEPSDAANSHSWEAHDLHGSSEEGEIPWVLSGPSPEAVQAARAKLDAAMAEASKQDTIGFLILPDPRAYRHVIGPGGSEINRIRKKTGTKIQVPRDQSAGEAIEIQGSKEGVHQAKESILEVVQMNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1QI57</accession>
    <name>N1QI57_SPHMS</name>
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        <recommendedName>
            <fullName evidence="4">HCP-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_76528</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EMF16880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016910145.1"/>
    </dbReference>
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    <dbReference type="STRING" id="692275.N1QI57"/>
    <dbReference type="GeneID" id="27907282"/>
    <dbReference type="eggNOG" id="ENOG502S2P6">
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    </dbReference>
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    <dbReference type="OMA" id="WGIKKDP"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010972">
        <property type="term" value="P:negative regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052945">
        <property type="entry name" value="Mitotic_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43628">
        <property type="entry name" value="ACTIVATOR OF C KINASE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43628:SF1">
        <property type="entry name" value="CHITIN SYNTHASE REGULATORY FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF16880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="361" mass="39700" checksum="308171ECC1493E3F" modified="2013-06-26" version="1">MPGLKDLLKKKDKLAEGTSAVQSEPTRLPVPEFTFLRTTTETEEVIQPPTYPDDDQTRPDTTGKDKRRTLGWTSSPQPPTRPRDERRLSQRLHLSRRDRAQSAESSSNLPKDLPDAPQAAIAARPTSTIAEQREAQWEKRATILAMNSPFRDEQVRPEAQQAAPGGAGRSRSPSISDKTSDVNIQEAIRLHEQGDLIRSTEMFGQLADPKGANNALSQVLYGLALRHAWGLPAAEPEKAVHYLSLAASNSASVEEQALQSGLKKGGSAKGELVLAIFELANCFRYGYGVKKDSVAARQYYETAANLGDTDAMEEAAWCYLEGFGGSKDKFKAAQYLRLAEAKGSKGVAQSWIWKDKYNPKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>N1QIA6</accession>
    <name>N1QIA6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_120548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757835.1">
        <property type="nucleotide sequence ID" value="XM_016901615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QIA6"/>
    <dbReference type="STRING" id="692275.N1QIA6"/>
    <dbReference type="GeneID" id="27898752"/>
    <dbReference type="eggNOG" id="ENOG502S2AG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_685432_0_0_1"/>
    <dbReference type="OrthoDB" id="2118965at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38703:SF1">
        <property type="entry name" value="ALLERGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38703">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="402" mass="43592" checksum="3A7BE4092822CE05" modified="2013-06-26" version="1">MEEARHAIEAFLARNGHHDTTVHETVAPAVTHELVTRTEHRASLHDKTHSSEIHHYHTSVQPITQEEHSEEQNHNVVQDVEEQNFEYGDPEDTSRRLAELDAEYQNSREEVIAESTTTELPTIEGLHIHHHVHERIQPVIDKRTYETHIYHVVVPVREIHHNAAHYHPSSPLATVTLDQFKQAGGTLNGREERYDAFEGEPRAVSKALSGQTSFASPATGGNPQGGLVNIPAPNPQAQTDDAPAAAPPAKVSRVATFADPIAAPRSEPIPQSEFDPTTIASRTAPNSGIFRLPTRVPTAPATSLAPDSTAPTPDTSDSVPAPLPRAPTAPPTFAPTALAREPTIPPSHPLMRPATHIPREAYRQGLGRAGTGHARPSRSRPAARSRRTGSPPSPPPPAPATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1QID5</accession>
    <name>N1QID5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_158009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759064.1">
        <property type="nucleotide sequence ID" value="XM_016907762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QID5"/>
    <dbReference type="GeneID" id="27904899"/>
    <dbReference type="HOGENOM" id="CLU_1415994_0_0_1"/>
    <dbReference type="OrthoDB" id="3624042at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110860" evidence="1">
        <location>
            <begin position="22"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF10943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="192" mass="22149" checksum="DB6B8D921AC7AD7E" modified="2013-06-26" version="1">MQMSRHSTMSWMIFMLAGVLATPTSQVPRDVNSAAENTYHQATGGVKTGWDTMTHWDRPAHWSTQAHWDTMAHWFSSKRHGHTPKRVERGHQACRATDHVYWLTYHITIGADYDPARCLTLQDRLRKGESVSFWKCESDRDDDNEDEDHDDEDHEKGFFKIRFNTAAGREVGLNEDLATEFHEINGFNCPGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1QIE6</accession>
    <name>N1QIE6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TFIID-31kDa-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_69403</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758455.1">
        <property type="nucleotide sequence ID" value="XM_016909861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QIE6"/>
    <dbReference type="STRING" id="692275.N1QIE6"/>
    <dbReference type="GeneID" id="27906998"/>
    <dbReference type="eggNOG" id="KOG3334">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068315_0_1_1"/>
    <dbReference type="OMA" id="WNMKDEW"/>
    <dbReference type="OrthoDB" id="341924at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07979">
        <property type="entry name" value="HFD_TAF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003162">
        <property type="entry name" value="TFIID-31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051431">
        <property type="entry name" value="TFIID_subunit_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068">
        <property type="entry name" value="TAF9 RNA POLYMERASE II, TATA BOX-BINDING PROTEIN (TBP)-ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068:SF4">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02291">
        <property type="entry name" value="TFIID-31kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="189"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="232"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF10334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="244" mass="26023" checksum="20565CC4BCC499CB" modified="2013-06-26" version="1">MATNGAPTPPPSDQPATATTTTAKPATDNPSGQPITSSLDDGTSKRPRDARLIHAVLSSYGLTNYQERVPLQLLDFAYRYTSSILSDSLRLSSEGYTNLPPPTNASGRGRGAAAVDDGERITVTSLRQAIAARQGYSFQGALPKEFMLKEAEDRNRIALPKVEGGQAFGVLLPPEKFCLTGVGWSMKQEWDSEVEEDENGAATASGEDETMGGMEGGDDDEDEEGAGRMEDVFGEDPAEDVAME</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1QIK3</accession>
    <name>N1QIK3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF1752-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_146129</name>
    </gene>
    <organism evidence="4 5">
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="AreA_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021711">
        <property type="entry name" value="DUF3295"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28014:SF1">
        <property type="entry name" value="NEGATIVE REGULATOR OF RAS-CAMP PATHWAY"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitrogen regulatory protein areA GATA-like" evidence="2">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3295" evidence="3">
        <location>
            <begin position="97"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF17015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="581" mass="63450" checksum="D2547208FE247E7E" modified="2013-06-26" version="1">MPFRPERSLLRVEVPALHTIDTTSVENLFGMWSLFSKTGHAIHNGRRLENLSWRLWNRETFCCAPESPPARKASATAVRRTTRPQTTATATTGDMTAVPPLSTSLDSASSNGDHDHPASPTTPRSTQPRSTLYRNDSATGSVVCRGRERRLRPIDLENIVHTITETNMLEPIELPTRKSLSNPDECPSISAEQVLSQLGSPPMSRCSQKSDPTPDASVSQTTLLESSASTVASNVSQSSDMVGSQESSSTEMSTHNIIRGFVPGGASSSYRSQTNLATQPTPILKNSRSFRQPAPPKKKGPMFTIGTSSGEDESSLESHMHRSVLSDGLRAPGSQNSDGSKKQASFQDELSIAQAVAARHSPVFESDDDEDDISESAIEDDDDSSDWEDSDDGSGPSSVNEKDLFQRVDSRPNLTSRRSLLTTLMHEPDRAKALANAASRSTPAIRRSRTATPSGPSLATSPETGSHSQLQVPGLEVPRSKPIIMTTSNTHQQLSLSPRTTRRNMLSTELTESLRKNLLWERQHKSTGNLAALKRRHTSNDVKNLKQLPEPGPVLSQKEQKGIFSNEYFHAGLGEYHQKGW</sequence>
</entry>
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        </submittedName>
    </protein>
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    </gene>
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        <lineage>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
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    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502QQY8">
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    </dbReference>
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        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Arsenical resistance protein ArsH"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
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    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02690">
        <property type="entry name" value="resist_ArsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43590">
        <property type="entry name" value="ARSENIC RESISTANCE PROTEIN ARSH (AFU_ORTHOLOGUE AFUA_5G15030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43590:SF1">
        <property type="entry name" value="ARSENIC RESISTANCE PROTEIN ARSH (AFU_ORTHOLOGUE AFUA_5G15030)"/>
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    </dbReference>
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    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADPH-dependent FMN reductase-like" evidence="9">
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            <end position="233"/>
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        </location>
    </feature>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF11750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="344" mass="38818" checksum="F821D1A901FD42FE" modified="2013-06-26" version="1">MTTSTQINGDLNNTQVLRSTAEIPVDRAYIGKTLAIPEEDDDHEIRSRYRQGFLLNQSITKADWISKLKLSTVLQLSEANLKQSDNDRLRVLVLYGSLRGRSYSRLLAYEASRILHRLGCDVRVYDPAGLPVKDDVQHDHPKVQELRELSKWSDGHVWVSPEQHGNLTAVFKNQIDWIPLSSGSVRPTQGRTLAIAQVSGGSQSFNTVNSLRMLGRWMRMFLIPNQSSVPQAYTQFTDAVEPSDEEKYLEAEGGSRLKASGNRDRLVDCMEEFVKYTIVMRPHFALFGDRYSERKEREEKRLKKEKEEEEKAMSAAKEKAGEEGNAKSMASADGVVNGIDVNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJK2</accession>
    <name>N1QJK2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2 3">
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016903661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJK2"/>
    <dbReference type="STRING" id="692275.N1QJK2"/>
    <dbReference type="GeneID" id="27900798"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5360255at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF17416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="382" mass="40576" checksum="C76F94EB6B74D09E" modified="2013-06-26" version="1">MNAIHSRVAQSPFQPPSMSFGSLGQQSPSHTQQNDTTKFSSGPLASPPERFGSVQAPRTYSPIQLSHNQPVASSPFPGLQSTSLSLGQTATAGTDKQFSSVSSLPAPQKAPGHVMASAFEGNDRISMPAHLRSETQRAAVNSAYGVSPSSSDIPGRPETASSSLSQPPASRPITGDRSQARPVDNGTNTTSRSRPSSALELPPLPMPKSLKARPTSALQHGITAPAESEPQVVPARSTLDGQELLSQPRSTSEGMTFTSLDDAGHGSRNMVPKERVVEGSRTVAARNVSKSMPRISSLMDAPHEIEEAPDTNASASVPQNHDHSGKVAVSDQDVSLQRYAAQHPQVRDTALNKFMMDHLQDPAFTVLCADIENCWRRIALGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJV1</accession>
    <name>N1QJV1_SPHMS</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">SEPMUDRAFT_104728</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Dothideomycetidae</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765601.1">
        <property type="nucleotide sequence ID" value="XM_016900551.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="27897688"/>
    <dbReference type="HOGENOM" id="CLU_1225447_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF17480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="226" mass="24947" checksum="8F8552EB5F1624A4" modified="2013-06-26" version="1">MLLIEFQTASWKFTWNTYTRQYPTYLTSRYLQDAALDFFSDNELPSCMYNVDGTSLLYIVSLATYLHTTPLYSPPLHILARGAVFQLCVSSRWDDRHHVLRRAQCYQQLQPRDIGLNVEWGVRRSLARSLITMGGTSSVGHPLRLPPTGTGTLPPGRKNLGSAATTVRPTAGTEMSLGWSAHSAQAIALRAVLRGTYERFVAGVGDQPRQPACDTGIACGSAGYTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKD9</accession>
    <name>N1QKD9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_146674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016903789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QKD9"/>
    <dbReference type="GeneID" id="27900926"/>
    <dbReference type="HOGENOM" id="CLU_2039520_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF17701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="121" mass="13654" checksum="B5E756A73873AC9B" modified="2013-06-26" version="1">MTLYFHISIFRHNFSSCPVRLALSYCIQTSFKTHIIPHHTSSQHPSSSTSSTHNPKLNAATTPTMSSRLSKNALQTTNPKVRYMYFCTFSSSSSFLSACPHVPTHLPLLHQTQHSQHQLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKK3</accession>
    <name>N1QKK3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_123061</name>
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    <organism evidence="2 3">
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        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765836.1">
        <property type="nucleotide sequence ID" value="XM_016901822.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="27898959"/>
    <dbReference type="HOGENOM" id="CLU_1975898_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF17715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="127" mass="14283" checksum="81876E2E2BA848B6" modified="2013-06-26" version="1" fragment="single">MDDVQKFLDESPADTYFSIAADAHHWAEFNYPPHLVHDGYVPIGPQNTNDITTPATYHSTPTTSEETSAIPGASRHESVELRPAIRRRRTTPAHPLTSQKTLTGRTSKRSARRRHNPSLQNQRVVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKW9</accession>
    <name>N1QKW9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_161019</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765961.1">
        <property type="nucleotide sequence ID" value="XM_016907919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QKW9"/>
    <dbReference type="GeneID" id="27905056"/>
    <dbReference type="eggNOG" id="ENOG502QQ9Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006273_0_0_1"/>
    <dbReference type="OMA" id="ATIWIGE"/>
    <dbReference type="OrthoDB" id="26399at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008448">
        <property type="term" value="F:N-acetylglucosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006046">
        <property type="term" value="P:N-acetylglucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113:SF14">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="3">
        <location>
            <begin position="327"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="711"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF17840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="945" mass="101887" checksum="E7D35F4A94C2EB3D" modified="2013-06-26" version="1">MDKIEAFEGLPAYTRTDQYAVQHRRRRLRRRVLRFSVLASGLLSTDRLQEDYATCAKLRTKPEDPSGHRNVSARYVEGVKPVLIQNATVWTGEPDADTGNYSWARLDVLLQYGLIQKVSEHISKDELPDEYDLVEAAGRQLTSGIIDMHSHTGVDSLPDLQGNDDTNELSKDITPYVRSLDGFNPLDPQFQVIKSGGVTTSLILPGSGNNIGGEAFVVKHAVGKANGRPELSIESLLADPDRNHRYIKMACGENAKRVYGKAGRNFGPFSRLGEAWEFRHAFEQAAALKNSQDDWCATADAVGAEKMTTYLPKDLQWETLAAVLRGQVMVNTHCYTIPDLESFIGYTNEFKFPVRAFHHAHSTYLIPDVLKRAYGGRAPAAALFADNMNYKAEAYVASEQAGKILYDEGITPVYVSDNPVINAQHVVFEAAKAHRYGLPYHAALAGVTSAPAELLGLGSRIGKVKSGYDADVTLWDSDPLSVGATPVQVFIDGVPQFKDPVELQKPVTPSMETTDYPVLVKQDNPVNSVVFTGISKIHLPGFEHTRDLHENASLVVANGKIVCAGPCEHAISATSNIIALSDGYITPPLTAFGSLLGLEEIAAEADTSDGSLSEDSFSHAVDGLRFEGKNLAAAYNHGVTKAITAPKFAGTEHKGISVAFRTGAKHALEKHAIVNPAVALHYTLTSDAKQGKTPTISSAIADLRSKLLNAIPSSNDTKGGEEKKQQQQPLQPEDLALSQVVNGTLPLVISVHSADTIASLIRLKHEIESAINISSSSPSSSSPQPKKLNLILLGASESHLLAHELSSSSISIILSPLFSYATTWDQRRALPGAPLSNGTAIDVLHNAGVRVAIGVDEDWEARDLFLQAGIVHANSGGKIGEEEALDMVSRGIEEMMGLKGESGGGEEEEDDDEFSEFVVFEGNPLTIGGQIRAVAGGDGGVRIWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>N1QLJ6</accession>
    <name>N1QLJ6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_87728</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760267.1">
        <property type="nucleotide sequence ID" value="XM_016910453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QLJ6"/>
    <dbReference type="STRING" id="692275.N1QLJ6"/>
    <dbReference type="GeneID" id="27907590"/>
    <dbReference type="eggNOG" id="ENOG502SJTI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004083_7_3_1"/>
    <dbReference type="OMA" id="GYVQWHS"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF50">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="17"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="82"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="143"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="573"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="646"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="661"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF12146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="764" mass="86639" checksum="58D4B6E9BAB8F51D" modified="2013-06-26" version="1">MSEALLLQNTVNKPGTSCLGCRRRKLKCSREPEGCFNCTKSDLPCVYPQPDVGVKRKRGPYKKDKPPRQRHLEDLVKYLEPKAGSSESPTHEVSASPGQALSSAHPGAIPHPAANGRPPSQPADQQSLVTDALVALTRSAAKDEDLRKDDGGLGMQHHQTAAPGPYYSSSNPHPTPRRIFEYWQLFVTRVDPMVKIIHCPTYYKKVLNVIDDPVNVPSQTSAMMFSIYYAALSTCSAQETRERFGEAQEVLIARYGKCIKDAVRANYDAPQLEGLQALVLYIVCIRRSDKVSDIGDLFHEAVRCAQFIKLEQDPEGRYPPFDVEYRRRLWFHLCGLESRTAEEGVSRKYSILKGQTVEMPRNLNDCDLNPRMTVPPRSRDGITDSTFPILRFEIHVLVFGIWNIRKNSPADVPGVTESQRSFYNLSKERLDRLYMMYMDDSRPYDWLCMNFVEGMLTKARLIINFHTGTVPTNTMPLADRMALLESSVDIIKRTHALAVDERISDWVWYFRGYVQWHSLAIVVAELGWSRDEKFVTMAWNVLDDILGEWDSLYQTKKDDPAWTHVNESIQRARKLRKRNRLSATSEGHNHHKKPRHTAPPTNHVHAPGPSGGGLAQSIAHLRQPLQHRPAPSSTMPQQYIQNAASSYYDGHPQPYTDERSQPYNNTTSLKNEGQTSESQVPGGPFGPGDEVSPMSSEGNFDDDPFPNVNWNAYNSVFTNDVWDTWNHMPDMQQCTLQNDTTSSAHTWWPPQQNMIMQNYGQYSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1QLP3</accession>
    <name>N1QLP3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Kinetochore protein SPC25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_145853</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Chromosome</location>
            <location evidence="9">Centromere</location>
            <location evidence="9">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the SPC25 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764774.1">
        <property type="nucleotide sequence ID" value="XM_016903303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QLP3"/>
    <dbReference type="STRING" id="692275.N1QLP3"/>
    <dbReference type="GeneID" id="27900440"/>
    <dbReference type="eggNOG" id="KOG4657">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065188_0_0_1"/>
    <dbReference type="OMA" id="HEDQRMK"/>
    <dbReference type="OrthoDB" id="4056921at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23784">
        <property type="entry name" value="RWD_Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.457.50:FF:000001">
        <property type="entry name" value="Probable kinetochore protein spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.457.50">
        <property type="entry name" value="Chromosome segregation protein Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045143">
        <property type="entry name" value="Spc25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013255">
        <property type="entry name" value="Spc25_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14281:SF0">
        <property type="entry name" value="KINETOCHORE PROTEIN SPC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14281">
        <property type="entry name" value="KINETOCHORE PROTEIN SPC25-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08234">
        <property type="entry name" value="Spindle_Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="8 9" id="KW-0137">Centromere</keyword>
    <keyword evidence="2 9" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="4 9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromosome segregation protein Spc25 C-terminal" evidence="11">
        <location>
            <begin position="190"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="91"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF16653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="265" mass="30913" checksum="DCA70FD142879F73" modified="2013-06-26" version="1">MSTITMTPSRFSSSLSGRHADAADYGAGAPSMADQLPTIDFNFDELRQRMAQFTQRFDEFIERGRKKVLEEKNAFRMNVADLEEKQRQRQQKISQLESESSSHAHILAKEAQEREEMHEAIRSLTAEREEHTNRRDQLKTEIASVQATIRQKKEAQAAHQRSLDVQARHNVPELRFWETCLGLRMEGTEVDDRLKFVFLRLDRRDEDRECWFEVHIGGREYEITSCRPRLDRDDMEAAQGRLNETKELGPFLKAIRSLFVDAVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1QLT1</accession>
    <name>N1QLT1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_145933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764889.1">
        <property type="nucleotide sequence ID" value="XM_016903349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QLT1"/>
    <dbReference type="GeneID" id="27900486"/>
    <dbReference type="HOGENOM" id="CLU_2122610_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF16768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="114" mass="12919" checksum="5857ADE9BCCD696E" modified="2013-06-26" version="1">MYYHQFPFFFFFFFTFFVTWGHFLGPLSGLCYYQLGRTGAIIVGPTTTRNGSGFPSAKDATHEQEIPAGLFAWELKALELIYGMENDTPRAAADIARLPALLLPSYCYMKTIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>N1QLU6</accession>
    <name>N1QLU6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Nicotinate phosphoribosyltransferase</fullName>
            <ecNumber evidence="3 8">6.3.4.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_145947</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>5-phospho-alpha-D-ribose 1-diphosphate + nicotinate + ATP + H2O = nicotinate beta-D-ribonucleotide + ADP + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:36163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8">Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the NAPRTase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.21" evidence="3 8"/>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764914.1">
        <property type="nucleotide sequence ID" value="XM_016903360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QLU6"/>
    <dbReference type="STRING" id="692275.N1QLU6"/>
    <dbReference type="GeneID" id="27900497"/>
    <dbReference type="eggNOG" id="KOG2511">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030991_0_0_1"/>
    <dbReference type="OMA" id="IEHCLEY"/>
    <dbReference type="OrthoDB" id="193380at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004516">
        <property type="term" value="F:nicotinate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034355">
        <property type="term" value="P:NAD+ biosynthetic process via the salvage pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019358">
        <property type="term" value="P:nicotinate nucleotide salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000183">
        <property type="term" value="P:rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.140.10">
        <property type="entry name" value="nicotinate phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041525">
        <property type="entry name" value="N/Namide_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040727">
        <property type="entry name" value="NAPRTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006406">
        <property type="entry name" value="Nic_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007229">
        <property type="entry name" value="Nic_PRibTrfase-Fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01514">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098">
        <property type="entry name" value="NICOTINATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098:SF1">
        <property type="entry name" value="NICOTINATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04095">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17767">
        <property type="entry name" value="NAPRTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000484">
        <property type="entry name" value="NAPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54675">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6 8" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nicotinate phosphoribosyltransferase N-terminal" evidence="10">
        <location>
            <begin position="3"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Nicotinate/nicotinamide phosphoribosyltransferase" evidence="9">
        <location>
            <begin position="134"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF16793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="404" mass="45410" checksum="1C4FDE41F343134F" modified="2013-06-26" version="1">MRLSREAFDWLSLQIDKLENVKVTHDELEWLRKTCPYLTAEYLDYLQTFTLRPKEQVTASFTPLVENSETPTTLGDVSLAVHGGWKETILYEIPLLALTSEAYFKFVERDWTHEGQREKAKHKGLQLLEAGCVFSEFGSRRRRDYKTHDLVIQGLLEAKKESHGKEWKGALTGTSNVHLAMRYGLNPIGTVAHEWFMGIAAVTQDYANANEHALQYWTGTFGRGVLSIALTDTFGTPAFLKAFSKPAPTSGHISDATRGNPTYAEIFTGVRQDSGDPLKFIEMMRTFYDSQGIKDKKTIVFSDSLNVERAIEYKQATEKAGLTASFGVGTFFTNDFWNPRTNEKSVPLNIVIKVSKAGGNNAIKLSDDVGKNMGDDKLVKLVKEQVGYADKSWADGDEAHRWDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1QLX4</accession>
    <name>N1QLX4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_130022</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="C:nucleoplasm"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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            <end position="618"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMF17232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="734" mass="79706" checksum="ADE944C788E1474B" modified="2013-06-26" version="1">MTTPARPGSSHHNHAHNYNHNHLDASANPNATTAAATVSARSPSSPTRFDNPRPSISPLSAKASPSAIREHAVQPDPAATATSRNHDDDDGSSILSEPEDELDAQAQQSQPDHVLATSEELAAHQSLEVDSEAETERLDQTPHKNRIQIGETGKTPSKLIQAATLEDELSDPPSPLPTGLGATSSTSTTDTLGKKRKRSDTADSSLSSADSELAESPRKRSHSAAPTNVPGTTLADAENTAVEPQDTAEELAVVSELKQPEVPTSSAKGNGKAKRGPKPKGRGKKDANKDAGAEDPETVAQTAEQSAEAKAKAAEEVKHKPAAAIAFEELAKQFAAFREKMINEKLAATNAELDLLNQPDSRHPEYLRQIACVNVRKAKQVSEAHAFYKFKLESLRRTTLGERSQLHSQYFQHARQLREDVMQQLGDDWYKIQNERRQNNQQEDESYIYKFPTKKSDQIKQQAKYNQEVSVLSGVAKYIGFPAAPNITGADRDMLEDDLKAMKISKRTQQPASHSQPVYFPNRATLIPPQSERIAHEQFIEQNPWARPQGPMMNHLTPNIAHTPDWAEPGTGTKQFARNLGIAVGPSQRVSPHATPLPQRRALFEQSSAGTTHASSDPTDPLPSADRAKQLNSDKDLASPLIVTKHRLNGDQLTGFRNISNISGASTIDAPGSAEKEPSTAAFLPSAAKEVSGAQHDFDTTPLQRQVAEVRRQSEQQPFRGPGEGVVHASGERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>N1QLY9</accession>
    <name>N1QLY9_SPHMS</name>
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        <recommendedName>
            <fullName evidence="7">Matrin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_146334</name>
    </gene>
    <organism evidence="8 9">
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        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="C:precatalytic spliceosome"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
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        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 4"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="zf-U1"/>
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    </dbReference>
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        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ZF_MATRIN"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="7">
        <location>
            <begin position="11"/>
            <end position="42"/>
        </location>
    </feature>
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        <location>
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            <end position="96"/>
        </location>
    </feature>
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            <end position="224"/>
        </location>
    </feature>
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            <end position="67"/>
        </location>
    </feature>
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            <end position="186"/>
        </location>
    </feature>
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            <end position="214"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF17257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="304" mass="33069" checksum="82F61DB3DA9B8091" modified="2013-06-26" version="1">MSEYWKSTPSYWCKFCSRYVRDTAVERKSHESSAQHQNNIQRSLRELHKGKEREERDKQRAKDEVRRLNGLVGGQTTARTPPPPVSASPDVARTSKLAPSTTAATTAQQRIAHAEQLAAMGVELPEDLKKAITGVGSFELVAAQEVDATPTDAVTVHRSLADILAQERQEQSGIKAETVEGEHVGEKSQSAGVKHKADDGDDDEHDPRDEDAAPKRRKVWGSATKAYPGKAEEVDVGDLDALLGRVKPTVGKVEDGDEVKQEEGLPGKSLSEVPDLIGNATVATTETEAPATSTVMFKKRKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>N1QM51</accession>
    <name>N1QM51_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">O-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_137687</name>
    </gene>
    <organism evidence="5 6">
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        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016902848.1"/>
    </dbReference>
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    <dbReference type="STRING" id="692275.N1QM51"/>
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    <dbReference type="eggNOG" id="KOG3178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005533_1_4_1"/>
    <dbReference type="OMA" id="GTDYYDW"/>
    <dbReference type="OrthoDB" id="1606438at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF12">
        <property type="entry name" value="STERIGMATOCYSTIN 8-O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="162"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF16953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="382" mass="42499" checksum="173B815157436C69" modified="2013-06-26" version="1">MPSPENLASAIKDAVVKIESISAENDLPVPSFDEDAVYHVSEKVSQEVDIVLDATAELHDLFSGPRDLVHRHCGLAAKVQGLTSFKEMAENTPLTESMATRLIRHAITMRIFCEPQVGFVAHTAASKLLANPAMNDYLLSVTRERWPAATKAYSLAKNTNETLYEIYNKDTKQAAWLARGMTAFSKLPQFNISHTLDHYPWMSLEDGLVVDVGGSHGHVGFQLAQRFPQLRVIVQDLESVVASASVPPELSERVSFMPHDFFTPQPVAGADVYFLRLILHNWSDTYCLRILSSLLPALKDGCKVIVEDNLMPDYGSKPLWKERKARTADITAAILFNAAERTAAEFELLFSKTDPGFALQQVIKPPGSQLSLLEFTWRKSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1QM99</accession>
    <name>N1QM99_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mediator of RNA polymerase II transcription subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_145725</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Mediator complex subunit 7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764610.1">
        <property type="nucleotide sequence ID" value="XM_016903228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QM99"/>
    <dbReference type="STRING" id="692275.N1QM99"/>
    <dbReference type="GeneID" id="27900365"/>
    <dbReference type="eggNOG" id="KOG0570">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065214_0_1_1"/>
    <dbReference type="OMA" id="MMQDHLD"/>
    <dbReference type="OrthoDB" id="10253553at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037212">
        <property type="entry name" value="Med7/Med21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009244">
        <property type="entry name" value="Mediatior_Med7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044888">
        <property type="entry name" value="Mediatior_Med7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21428">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21428:SF11">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05983">
        <property type="entry name" value="Med7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140718">
        <property type="entry name" value="Mediator hinge subcomplex-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0010">Activator</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="26"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF16489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="244" mass="27387" checksum="223D3F69BBB87484" modified="2013-06-26" version="1">MAEEQQQQLISPFPAPPPFYKHFTKQNRDRVQQLRREAGASQNDGAKEHDIDTTTLPPELGCLVPPPPPSTTKFTVFGHEIDLEAPQPTLAEAGIEQLYPDHPSVTTTPQPHLIALSRSLLTTFLSLTGILAANPELYEERVLDLQAIVFNMHSLINQYRPHQARESLIMLMEDRVEKMRAETRAIEEGREKVAKLLEGMKQHADYAPDVIAVNGKKVGERNLVAARKKGRRSAAWQMLEAEMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1QMW3</accession>
    <name>N1QMW3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Metallo-hydrolase/oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_57751</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(3R)-atrochrysone 2-carbonyl-[ACP] + H2O = (3R)-atrochrysone 2-carboxylate + holo-[ACP] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:64236"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:20479"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:234107"/>
            <dbReference type="ChEBI" id="CHEBI:234110"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:64237"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765509.1">
        <property type="nucleotide sequence ID" value="XM_016909450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QMW3"/>
    <dbReference type="STRING" id="692275.N1QMW3"/>
    <dbReference type="GeneID" id="27906587"/>
    <dbReference type="eggNOG" id="KOG0813">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048478_1_0_1"/>
    <dbReference type="OMA" id="QLVTAMH"/>
    <dbReference type="OrthoDB" id="17458at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07722">
        <property type="entry name" value="LACTB2-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000041">
        <property type="entry name" value="Metallo-beta-lactamase domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047921">
        <property type="entry name" value="LACTB2-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050662">
        <property type="entry name" value="Sec-metab_biosynth-thioest"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131:SF3">
        <property type="entry name" value="ATROCHRYSONE CARBOXYL ACP THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131">
        <property type="entry name" value="ENDORIBONUCLEASE LACTB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="7">
        <location>
            <begin position="59"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF17388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="336" mass="36927" checksum="5B2F088A298C16E0" modified="2013-06-26" version="1">MEDDKGGYRQINKSLNICAFEDYLQGQTARLPQLADVEQLTPRVLRILGQNPGRFTFQGTNTYVIGTGHTRLLIDTGGGEPEWAELIAKTLESMDIKLSHVLLTHWHGDHTGGVPNLLLRYPDLHDAIYKHTPDPGQQPILHSQRFCVQGATVRAVHTPGHSEDHVCFVLEEENAMFTGDNVLGTGTSAVEDLGIFMDSLHIMRDQNCQVGHSAHGAVIQDLPAKLNQEIAGKLRRERQVLQTLNKVKTSGEKSVTVKDLVLKMYGDNVDPATRELALEPFMDEVLRKLAGDGKVAFEKRAGIKKWFSLAKPAQAAATPHPAKAGGLKPLTAIRAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1QMX0</accession>
    <name>N1QMX0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Endopolyphosphatase</fullName>
            <ecNumber evidence="3 12">3.6.1.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SEPMUDRAFT_146430</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the hydrolysis of inorganic polyphosphate (polyP) chains of many hundreds of phosphate residues into shorter lengths.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>[phosphate](n+1) + n H2O = (n+1) phosphate + n H(+)</text>
            <dbReference type="Rhea" id="RHEA:22452"/>
            <dbReference type="Rhea" id="RHEA-COMP:14280"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16838"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the endopolyphosphatase PPN1 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.10" evidence="3 12"/>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765519.1">
        <property type="nucleotide sequence ID" value="XM_016903650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QMX0"/>
    <dbReference type="STRING" id="692275.N1QMX0"/>
    <dbReference type="GeneID" id="27900787"/>
    <dbReference type="eggNOG" id="KOG3770">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013424_1_1_1"/>
    <dbReference type="OMA" id="WAERYSV"/>
    <dbReference type="OrthoDB" id="348678at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000298">
        <property type="term" value="F:endopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004309">
        <property type="term" value="F:exopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006798">
        <property type="term" value="P:polyphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012358">
        <property type="entry name" value="EndopolyPtase_N1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF55">
        <property type="entry name" value="ENDOPOLYPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027093">
        <property type="entry name" value="EndopolyPtase_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 12" id="KW-0926">Vacuole</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004111017" description="Endopolyphosphatase" evidence="14">
        <location>
            <begin position="20"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="15">
        <location>
            <begin position="49"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="464"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="537"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="601"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="472"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="551"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="607"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="623"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR027093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMF17398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="678" mass="77657" checksum="50A06671A2613FDC" modified="2013-06-26" version="1">MRVCAGLFAHVLLAVQTAAAPPAQVPLSESFKEPLGDAQIGKKRPLHGRFLHITDFHPDRFYEVYTSTSEEAACHRGQGPAGIYGAETSECDSPIALINKTMDFVAKEFKDKVDFVIWTGDSARHDNDDDLPRTSEQVLGLNKFMVQKMAEVFGKHDGDEEDEDPNNDFIIPIVPNLGNNDILPHNILAKGPNKWTRAYAGLWRQFIPQVQSHSFEQGGWFYVEVIPGKLAVFSLNTMYFFGSNAAADGCALHGEPGYQQMEWLRVQLQFMRDRGMKAMMVGHVPPVRQEAKTLWDETCWQKYTLWTRQFRDVIVSSHFGHFNYDHFMFQDFKDLKKGTKKGQMQSLQALQEDDDVSAQVKPDYFLQLRDEWSKLPSPPQAKAHNWLVMAFGKQKDFKKKQKKYLKKIGGKYAERFSASFVSASVVPNLFPTMRVFEYNITGLEHHNFDQSTIPAPAPFDFNSTGVSIDGKKKQKKKKKAHKKYKFTVPEAPSKSSVPGPAYSPQTFSLLRYQQYFANLTYINNDFTQDLSGTGASAAKWHEGKHKGKKPHEKDHKPTPRKFKYEVLYDTKEDKVYHLDDLTVPSMIELARRIGDFKAEGASEMDEDGHVENECREVSDQGKKKEKKKHGKKKHGKKKHHKGGKKHRHRQRNEAWYTFVRRAYVDTMSPEELEDEFGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNU9</accession>
    <name>N1QNU9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_146613</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765770.1">
        <property type="nucleotide sequence ID" value="XM_016903768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNU9"/>
    <dbReference type="STRING" id="692275.N1QNU9"/>
    <dbReference type="GeneID" id="27900905"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_15_0_1"/>
    <dbReference type="OMA" id="DQKVFQG"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="147"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="253"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="220"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF17649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="337" mass="37397" checksum="34BD8C3565D6CC2D" modified="2013-06-26" version="1">MFALRRIAVRALQYQPTRQISTLRPVSLTSRIESSKPSFYRSFHQSQKWLAEEEQQKTQEGSAEPTVTVEPSTEEQKEITEKSIASSEVADAASDSALPQSATQATEEVKNVASSAKDALSGAAEKVVNMVRPSSRFQFPNEPGKDTVLYVGNLFFEVTAQELEAEFGRFGEVVNSRIVKDPTGSSRGFGFIELSTTEAAMNAIRGLDQKVFQGRRMLVQKHVRKDKPKSPGGSYAPRDRDAPRDRASASPSKTLFIGNMSYEMSDRDLNNLFREIKNVLDVRVAIDRRSGQPRGFAHADFTDVESAEKAKEFLGSKMVYGRQLRVDFAAEPSKPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M3ASW3</accession>
    <name>M3ASW3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_53736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016909275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3ASW3"/>
    <dbReference type="STRING" id="692275.M3ASW3"/>
    <dbReference type="GeneID" id="27906412"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009650_2_2_1"/>
    <dbReference type="OMA" id="ARIYNPG"/>
    <dbReference type="OrthoDB" id="3353407at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021822">
        <property type="entry name" value="DUF3405"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36205">
        <property type="entry name" value="CHROMOSOME 19, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36205:SF2">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11885">
        <property type="entry name" value="DUF3405"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="555"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF08599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="617" mass="71436" checksum="946212F4D28FFE9D" modified="2013-05-01" version="1">MITLPQRSSIEPHRLPQRQVLRDWSNAKDTTTTHPRVPCTGARGVLLDSSNVLDVPRPTQRDLGRDYPEPTFGSYDALGLSKGWMTFEQRYGPYGYEKNSSSEARHTSPSVDWNSVDWGALVDECAKANDARFRLPKVMSQRRPRFRLFDDNDAKQHQEEEETEVPQHETGRQAIILRTWSTYEYYPEDLWNLRSIITEASLATHGDYQVFLLVDLKCGEACQDVFTNATLHQEILEKSVPKEFWNVAVLVHENLQRSWYPKVEETRSMWQIMQPLQLFAHFYPEFDHYWQLEMDARFTGNVGNMLQAFDLFGREQPYKQARERASWAYMSSQHGTYAEFSSAINSSLNGNATIWGPDRIKNVEPLLLPNNNDNKNDPLPPSPLQDNFTHALHRPADLLLLTQLNDVRLFERHSDWVFAEWYLGGFTPHIPRYMSVPAQARASYSLLEAIHRSQHEQGLRVASEATLPSWALWLGLKIVGLPIPRFQFPEREAHELGWVLNGGLPGEKGRFEDGIARGDGVYRGSSLGFFLRPLTFDWWSSLCDPMWEWWMMEGEEGEDGEREREEEERKKKDGNHPEYVVVPKKELPGFMHMVDGEVYMPEMLLHPRKSNLYHAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>M3AUZ7</accession>
    <name>M3AUZ7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RhoGAP-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_90781</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF09896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758017.1">
        <property type="nucleotide sequence ID" value="XM_016910536.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.M3AUZ7"/>
    <dbReference type="GeneID" id="27907673"/>
    <dbReference type="eggNOG" id="KOG4269">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002671_0_0_1"/>
    <dbReference type="OMA" id="HQMFSDL"/>
    <dbReference type="OrthoDB" id="185175at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13277">
        <property type="entry name" value="PH_Bem3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000452">
        <property type="entry name" value="Rho GTPase activator (Bem3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF129">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN AT 16F, ISOFORM E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="873"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="4">
        <location>
            <begin position="1146"/>
            <end position="1342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="274"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="394"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="676"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1052"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1366"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1408"/>
            <end position="1469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="289"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="329"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="414"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="467"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="484"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="542"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="591"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="690"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1075"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1368"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1460"/>
            <end position="1469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF09896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1469" mass="160010" checksum="E69C885CA91B2814" modified="2013-05-01" version="1">MAAPLQWPAAASTASVTTTGSVTGTHGPTISDSLQHSHASREPANGLQSVRQKTISSPLISPASSRGHHQQPHQQSPITQAAPSLSVRKPNPAKKVVRGNDDELHQAITREAVTEEQRSIGQVQSPHHQQQQQQQQEAPPKLDPAHQTFLRSAPTIMSNPQAAIRPAPHDRIPMMAQRTASIDSTVSSVSSMSNHRPINSGTTNAFRVSQESQGPQDAAALIAAAGSAEAALQKVLQEKQQAASHNAQLWRLVEKQRSMILGLNKDLEKSLKEKERYRRKLKDHISQSTPAPTLTPTDAPTVQGHSRETSESLSPLTPIPAPVRDISVDTLQTSDGSGSASNSIGRSDTPQDAINSHLMNQAGVASSPTGSQQTIHHDTRPATIDTRAAALATVQRTPTGTPPMSLKSAETVHSPKNSISHSKNHSTSSYHSSPPASATGNFSPKTRKAPPAPLRLDPPTTRPDPSVNDDVEDASDSEYEEDPESARSEFADRGRRKTREDDDREREVLAQKEAEQRSMSKKDKKSKSRAAEESSIVAQPGAAEHAVAEAARLNGPWSEPNPYEVVHNRAASDSQSRTLAAPSAMLSPGLPMSPRPGDRPPNSPMPRAPVTQLANSMPLSPRAGVAGLPLSPRAPRSAIPLPPQTPMALMSPHLDRAKAYAAQAPHFQALANLADRMKPMNGGSPDQGRPSMSSDQSSVHSPGEIYKGLQTEDYPDLLLPPNALPSIYVKTASSRMVRSRVSMLVSKAADENPVFTLAVHERSQHKELWRVEKTYQALSQLDYDIKALCRISDRIPDKTLFTGHAPAKIDARRMALNVYFERTMDCVTEEKAARIFCKFLSTEAFAPEKSDYFTSNEQNKRPDSPAVTPLRLRPNMAGYLTKRGKNFGGWKARYFVLDGPLFKYFEGPGGAHLGSIKLQNAQIGKQSANPNQNAHDDEDNQFRHAFLILEPKKKDSSALVRHVLCAESDAERDQWVDALLHYVDYREVEDRLQPARQAQVAKTELAARSPRLQKSMGDLRTATAFSQDAAAAQAKVDLQSVGYNDTVAGNAPIMGPVTSRGGSDTPSPPHDKLATDQSYPTISGPTNLQVISDTENWGMKVPPTPGKDKKRSVFQLPFTRGRGSSDQEPKDAVNEHAYSTRAVFGASLADAVAYSQPAGVDTELPSVVYRCIEYLTARQAVAEEGIFRLSGSNVLIKALKDRFNTEGDVNLLEAHQNYDVHAVASLLKLYLRELPASILTRDLHLDFLHCLELPAEEKVPALNVLVNRLPRHNRALLEALSAFMLLIVNNVLVNKMNVRNLGLVFSPTLNLPGPLISLFVEEQYSIFRMPAELEASNAASFGHAVQTPPSDDLRSPRRQMFQDLPTPAYNQTQFQPGSGSSNDDTGMIPMQPTYAAYPYQMAPQGDGGYGSLNDALRSPTVYSSTASGAPSPRDTKQRRRESTMLAVSREGPTKKPSQSRLREEHGTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M3AVV5</accession>
    <name>M3AVV5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_50635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758337.1">
        <property type="nucleotide sequence ID" value="XM_016909171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AVV5"/>
    <dbReference type="STRING" id="692275.M3AVV5"/>
    <dbReference type="GeneID" id="27906308"/>
    <dbReference type="eggNOG" id="ENOG502RXIB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042941_4_4_1"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF13">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF10216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="183" mass="20614" checksum="C59B3993D9A0090B" modified="2013-05-01" version="1">MTQATRTITSVAAQNYTIHKSYGGDTRYMSLDSQFDTLWNHELVPDNGVINLPPYDSSGKTTVNEYGVIGMLHALHCLGGIRRAMQTARNDALSRNGHDIGLDYKSDPHWPHCFHYLRELILCHADDTIERAHFLNGTVSLAGQAPAFFEGQLDVRQCRDSEKLFQTRKLHSDSNKDGVPNVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M3AXC2</accession>
    <name>M3AXC2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_157424</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759501.1">
        <property type="nucleotide sequence ID" value="XM_016907733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AXC2"/>
    <dbReference type="STRING" id="692275.M3AXC2"/>
    <dbReference type="GeneID" id="27904870"/>
    <dbReference type="eggNOG" id="ENOG502STHF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_335284_0_0_1"/>
    <dbReference type="OrthoDB" id="3945293at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="314"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="549"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF11380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="851" mass="94753" checksum="647FCD06515786C3" modified="2013-05-01" version="1">MHRPRADGREQLISVRPRPLFIFSLMSCSRLKLMLMASHAMPCHTMPCHCSPPRRGIKKDGPLPSQYKHNWRCFHCSHDSKALAVNPHGPTASYLLPPTSYLLGGISRVEDGHQYFYLQRTTTVYTPQQQTQTAQTARASERPISLHVQAIARSINRSHGLDQHGAGSISHVMSITLCDNNTPLKRALLYCMQQERRLHSHGLNKKEHFHPTALARGKEPPGEIALAIPTTTTTPPPPPPRVERHCGQQTFLDRRLATAIMTATNIRHLVQAAGNDERRTMSVAVAASQFHVAGTMKHDRQQLTAHSFYAGYKNDPARQLPTELMIHIFGYLPLFDAWRLQLVCKSWHLCLSADATQRALLARWETHSPADSARSCEQQQQQSVTDMVRHMRAWCLNLPFSTAKIQTGRAVMQRGLQSQAQRTLALSGGRLAFLDSDVHLGDVVVVRNLLSEMPDYRLRPAARERIMALALTKKLVACLTFAGKMYVQALPDTSGPLKAITLPSSSVTAFHADDNVIGLTVGNAGGPTGSLLLYSHATGRMAQQTIRYPSPTETAPVEGSHSPPANASPGVPRIAPSSMLVNETTGTTDLFYSSEVALAHGTDDQSEFLWFAHQRYHNKPGQLGRTDLAAVEQEDVLRLPMQPDLIRLEGGALAAPHPTGLRSQWAFSTSFAKTMNHVRPLTCMIPMFDAKKGKLYRQHYPFPDHYSPQDIRRLSIWKGAVHTHPRLSDITPIYKIRDDASPTEGLPPSRRWVDAVALLGEAHGEMQEVALNDSFLVLKSISSPPETSSSHITIWCFESNFDWRMDGKTEVWDWDLNEMANKAKDLQDPHGTARRHVSCELPAEVVIRSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M3AZJ2</accession>
    <name>M3AZJ2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SEPMUDRAFT_149457</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Dual chitinase/transglycosylase that plays a role in cell wall architecture. Chitinase and transglycosylase activities are coupled. Required for the polysaccharide cross-linking at the septa and the cell wall. More specifically, transfers chitin to 1,6-beta-glucan in the cell wall.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the glycosyl hydrolase 16 family. CRH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761043.1">
        <property type="nucleotide sequence ID" value="XM_016905564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AZJ2"/>
    <dbReference type="STRING" id="692275.M3AZJ2"/>
    <dbReference type="GeneID" id="27902701"/>
    <dbReference type="eggNOG" id="ENOG502QQ71">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027506_2_0_1"/>
    <dbReference type="OMA" id="WYIMFGR"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02183">
        <property type="entry name" value="GH16_fungal_CRH1_transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000152">
        <property type="entry name" value="Cell wall glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF68">
        <property type="entry name" value="GLYCOSIDASE CRH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004031941" description="chitinase" evidence="14">
        <location>
            <begin position="32"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="15">
        <location>
            <begin position="39"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMF12922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="482" mass="50054" checksum="E1A1E1655227D5C9" modified="2013-05-01" version="1">MLTLNSLLSMRSPLRLASIAAIAALISPSTAQTYSTCNPTQQSGCTPNPALGKSLTINFADGESDQFTASSNPTYGPDGAVFTVAGSGQAPTLTSKWYIMFGKYSVTMKAAPGTGIVSSAVLQSDDLDEIDWEWLGGRNDEVQTNYFGKGQTTSYDRAAVHAITNTQNEWHTYTVEWTKDQIVWSINDKTVRVLNAGDAQGQYPQTPMQLKLGSWAGGDPSNSEGTISWAGGAVNYAAGPFSMYVSSVSVVDYSTGTAYSYGDQSGTWESIESTGGEVNGNSGGSVTVADAPAITSTTSGNEGWSGTHATNTATVSYTTLPGLPSGWTISGSGKVVPPSAAPSPYPSALLSPSLSVSAVEASPTPSGGSPKTEYNQQGFLVTIYVPAGASTGWNDKGLATTWLADARPTPVAYGHALADELKAVAGTQTGLATLATDDGSNFVTVSVTHSNGAPARRTVGSPSWLSTWPIWTIPLVLLLCVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M3B0K0</accession>
    <name>M3B0K0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">eIF-5_eIF-2B-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_148657</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:negative regulation of translational initiation"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="entry name" value="W2_eIF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000031">
        <property type="entry name" value="Eukaryotic translation initiation factor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.350:FF:000001">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Eukaryotic translation initiation factor 5"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016190">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
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        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001:SF7">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 5"/>
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    </dbReference>
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        <property type="entry name" value="eIF-5_eIF-2B"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="eIF5C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Translation initiation factor 2 beta, aIF2beta, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc-binding domain of translation initiation factor 2 beta"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="W2" evidence="7">
        <location>
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            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="145"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="147"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="161"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="184"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF13312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="418" mass="46824" checksum="997A91C2DC94893D" modified="2013-05-01" version="1">MANVNIRRDVADPFYRYKMEKIQSKVEGKGNGIKTVIVNLSQVAYQLARPPNYVIKYFGFELGAQTNVDPKDDRWIINGAHEASKLQDYLDGFINKFVLCKECKNPETVVNIKDGEILFDCKACGKISKADLRNKLSGYILKDAPKKGKKDKSTKKADRKARKEAERNGTLEKDGSPGDSGSDPVEDEVEDEGNASDDDLTRRINAEAKELAEIKEKEVEWSVDMSEAAVKARAQALPEDLKNTLVIENGDDAEGGDNAFEEFGKWIESKAEEEGGITKVKDVDIYLKAKELGIESKHRTPAVLAQCIFDDSIVKQIDTRAAMLKKMITSDRHEKAFLGGIERFVGIDKPNLIPSVSAILLKVYENDLATEENLKAWCGKASKKYVDLQTSRKVRKSAEKFLEWLENAESDEEESDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M3B0P4</accession>
    <name>M3B0P4_SPHMS</name>
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        <recommendedName>
            <fullName evidence="3">Peroxisomal membrane protein Pex17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_84109</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016910346.1"/>
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    <dbReference type="OMA" id="LMVQWRQ"/>
    <dbReference type="OrthoDB" id="2357318at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055334">
        <property type="entry name" value="PEX8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39214">
        <property type="entry name" value="MICROBODY (PEROXISOME) BIOGENESIS PROTEIN PEROXIN 8 (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39214:SF1">
        <property type="entry name" value="MICROBODY (PEROXISOME) BIOGENESIS PROTEIN PEROXIN 8 (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pex8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF13347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="689" mass="75910" checksum="C68EC91866E94843" modified="2013-05-01" version="1">MPSDRLLGTLLRHLQIYTDQQDTPRLFGTASSLLTSLNNPLNVTLLTSQLLSAPAIWTAPEGLRSCMRMISVFHAAAQALIKHENAVRDKVPDVEFSQLQHERTLAKEDWIQAVIGGADDHSPRWRHLLAISGLLLGFGAPEDENISLNMRNKLESALVTAANLSLEEIQDGDELAQGGITLVLNHCFPVLTNYERSKLAYDLLLPVLMKTTFYSSEGLQSAYFLGALDQDIQVAGSGKLSWSEQSQSYQRIQHLSSGPLIKSLGPLARLVGHTIEQVRDPWLVTAALDDLSNFARTVITQWRQNRLCGVETSEQSKYLDENTITTTSPALFRLLQSVLFSAVIIMRSGLGRVLGDSTLASDDLAPSIAQQTLHILRNLYFITTRQGASTFSQYNFVYYTAMDILSQYPGKVEAFLRATHPPQIGTVAHHPLDRTLDLFFLNTVEHFTLILPTHLTADIIVPVVTSYLAAGGKGPLLPVFEAAHSVTLAVFSAPQNAQATIANLPFYVDSLFRVFPSNLSARQFRLAFKALLKLTSPPSALAVEQPMMPAVLLDLLHDRALRAETTPIPIHPGTPEGSTESPMPLSEQTVLTLTVIDGLTQVPLDLLDEWLPITADMIHDIQDGNMREHSKQHFWHILVESGELDPERSRVCHAWWSTGGGKEWVLYGRDEAALMSGGLDGGGMAESKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M3B282</accession>
    <name>M3B282_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_149020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761998.1">
        <property type="nucleotide sequence ID" value="XM_016905289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B282"/>
    <dbReference type="GeneID" id="27902426"/>
    <dbReference type="eggNOG" id="ENOG502R9B4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1185660_0_0_1"/>
    <dbReference type="OrthoDB" id="3621409at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF13877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="234" mass="25535" checksum="7954636316C18506" modified="2013-05-01" version="1">MGGSEKPDAHTCLLAYLYSAHGGYSPDLCSLVSGPGTQKKKQKEVSKHRGASHSVPLSLPTTSYCIPCDRCACDKALAGVLGWLHTLYFVLGTSRHDIARAEPCSTLVYLSDVHAPRKPMSLVHPSNIIRCQQGSSIISTMCFSNTITWKKCGHYAIRRVFCEDAVARTPQEYCRNAFAPTFTDVDASNGVCPDRNKHPPAPGQPFTSAWSLQLGITTTSGEGNLWYRQNQGQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M3B2L7</accession>
    <name>M3B2L7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SEPMUDRAFT_147870</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762133.1">
        <property type="nucleotide sequence ID" value="XM_016904567.1"/>
    </dbReference>
    <dbReference type="SMR" id="M3B2L7"/>
    <dbReference type="STRING" id="692275.M3B2L7"/>
    <dbReference type="GeneID" id="27901704"/>
    <dbReference type="eggNOG" id="KOG0519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_3_2_1"/>
    <dbReference type="OMA" id="CLAAQMD"/>
    <dbReference type="OrthoDB" id="10266508at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071474">
        <property type="term" value="P:cellular hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06225">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000235">
        <property type="entry name" value="Probable nik-1 protein (Os-1p protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000010">
        <property type="entry name" value="Sensor histidine kinase RcsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000002">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1530:FF:000001">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1530:FF:000002">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1530">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18947">
        <property type="entry name" value="HAMP_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158472">
        <property type="entry name" value="HAMP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58104">
        <property type="entry name" value="Methyl-accepting chemotaxis protein (MCP) signaling domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="HAMP" evidence="15">
        <location>
            <begin position="203"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="15">
        <location>
            <begin position="298"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="15">
        <location>
            <begin position="390"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="15">
        <location>
            <begin position="482"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="15">
        <location>
            <begin position="574"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="15">
        <location>
            <begin position="666"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="13">
        <location>
            <begin position="740"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="14">
        <location>
            <begin position="1109"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1249"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="692"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1254"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="10">
        <location>
            <position position="1158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMF14012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1314" mass="143332" checksum="075C81D56A748C76" modified="2013-05-01" version="1">MPHEETSAAVASILSNFAKQYTPLDADSFPASAIANGVKSNKITLPGEDTVEKRTLERELTNLSTRIQFLETRAHSGLSSLPMTPNEPVTSAFITENASSPKGGALNPLNPRQRSASWVNSLLAKNEGEPQLRQLTEEQFTVLREHIDQQAQEIKTQKEFIDGIKAQLTHQQTATRAALDTLGNSQSIEQLKREIEKNAQINATYQKVLREIGTIITAVANGDLSKKVLIHATEKDPEIARFKHTINQMVDQLQEFASQVTNLAKQVGTEGRLGGQAVVPGVDGIWAELTQNVNVMAQNLTDQVREIAVVTTAVAQGDLSRMIQRPAKGEIFQLQQTINAMVGQLRTFATEVTRVARDVGTEGLLGGQAQIEGVQGMWHDLTINVNAMANNLTAQVRDIAEVTTAVAKGDLTQQVKAQCKGEILALKTTINSMVHQLRQFSAEVTNLAREVGTEGRLGGQATVHGVEGTWKDLTENVNGMAMNLTTQVREIAEVTTAVAQGDLTKKVQAEVQGEILALKNTINTMVDRLGTFASQVSRVAKEVGTEGVLGGQARVENVEGEWKTLTDNVNTMANNLTGQVRSISDVTQAIARGDMSQRIKVHAQGEIQTLKDTINDMVTRLDAWSLAVKRVARDVGVDGKMGGQAEVDGITGRWKEITTDVNIMAQNLTSQVRAFADITHAAMKGDFTKMINVEASGEMNELKNKINKMVLNLRESIQKNNQAREAAELANKTKSEFLANMSHEIRTPMNGIIGMTQLTLDTELEQNQRDMLNIVFSLANSLLTIIDDILDISKIEANRMILEEEPFSLRGLVFNSLKSLAVRANEKDISLIYDTDASVPDYIVGDSFRLRQIILNLAGNAIKFTEHGEVRVKIFSDTSVQCGEGEVVVKFAVADTGIGIHSNKLDLIFDTFQQADGSTTRKFGGTGLGLSISRRLVTLMRGKMWVESSYGSGSTFFFTCVARLGNPDVHKVMPQLQQYRKHNVLFVDNGFIDNSEQISASIRALDLVPCVVGNGRTPPSELSPQDQYDCVIVDNTETAQKLRGLERFKYIPIVMLAPAISVNFKTALENGISSYMTTPCLPIDLGNALVPALEGRAAPMSADHTRTFDILLAEDNAVNQKLAVKILTKHNHKVTVANNGLEAFEAIKKKRFDVVLMDVQMPIMGGFEATANIREYEKTHELARSPIIALTAHAMLGDREKCIQAQMDEYLSKPLKPQQLIQTILKCATLGGALLERKGDSRGSIHVEEAAPTTGASTSEGSSDQSRLAAPKRPNMTPRGATDVGPAGLESPAIVTADQDDPMTREALLRANSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M3B2Q3</accession>
    <name>M3B2Q3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fumarylacetoacetate hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_131799</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762178.1">
        <property type="nucleotide sequence ID" value="XM_016902450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B2Q3"/>
    <dbReference type="STRING" id="692275.M3B2Q3"/>
    <dbReference type="GeneID" id="27899587"/>
    <dbReference type="eggNOG" id="KOG1535">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028458_2_1_1"/>
    <dbReference type="OMA" id="EYKGQSP"/>
    <dbReference type="OrthoDB" id="411064at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000002">
        <property type="entry name" value="2-hydroxyhepta-2,4-diene-1,7-dioate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF100">
        <property type="entry name" value="FUMARYLACETOACETATE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G01490)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="83"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF14057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="296" mass="31879" checksum="E5971EBACB23F330" modified="2013-05-01" version="1">MAPAWTRLIRYISAQDGATRLGDPIVPSDQKHPDIDALALAGGLKVKVLQTGTNHPVHATPTDQEDVVKTLLGPLTPQDVPIVRCVGLNYKTHILETGFDLPENPTLFIKSPMTVADTRQPTPIPKLGQLQLDYEGELTIVIGKDAKNVSEEDALSYVAGYTSSNDVSCRDWQMEKSKAGMMPQWSFSKSFDKYAPLGPAIVSTSVLGDASGLTLRTMVNGEERQNSNTSDLCFGVKKLVSFLSTGQTLQAGTLIMTGTPGGVGLGFKPQKFLKDGDEVVVDIEGIGKVVTTMQFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M3B365</accession>
    <name>M3B365_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_148016</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762363.1">
        <property type="nucleotide sequence ID" value="XM_016904651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B365"/>
    <dbReference type="GeneID" id="27901788"/>
    <dbReference type="eggNOG" id="ENOG502RZ32">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045016_0_0_1"/>
    <dbReference type="OrthoDB" id="19092at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="323"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="123"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="395"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="11"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="159"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="281"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="408"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF14242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="424" mass="46509" checksum="6CE25953985EB1C2" modified="2013-05-01" version="1">MAEVMSAASAPYQQHTTGSSPSPASFGLATQQDQLEAVVPSRTMSQRSQKRADRSERTGGDRRRSSQASNPMPQSQSQQLAQPPPPPPATRTDRSRPQSAVQPAFSSNLSYAQVRDFAYPAYHSMHFGGPSEEESGVSAPTGWDAGRRLSESAESSTSGGKGWHAGPWGGDGVLYGDPEQDMEELPRTAFGTAGDDWGEDETSFKVNKHRKSRSFHDIPNYERGRRRESQGRSKAQEEGSQSQPQQYDPAGRDALRQSRGFILSENGEQLPRRDSHFAATTLPNRSFHTSQPVDPDSDLPLDAEPSLHHSPQRESMGPEDEELFAGPSLALYGFEPENENELRLTEGEVIMVSYRHGQGWLVAEKANGDQGLVPEAYVRLLRDIEGWDEETGQFIEGDPFGPDAEEVTTPTETPTTTTTTIIHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>M3B3D4</accession>
    <name>M3B3D4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_148062</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762423.1">
        <property type="nucleotide sequence ID" value="XM_016904674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B3D4"/>
    <dbReference type="GeneID" id="27901811"/>
    <dbReference type="HOGENOM" id="CLU_2559765_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF14302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="82" mass="9533" checksum="54F5A48409446910" modified="2013-05-01" version="1">MSAMQRPDGEDEQPLREVTMKAGDILRFKKDRSGLSKTKCLSSQNNPVRAEKKLPNNQCCFSHMFELVSYSVLFEIVYYNWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M3B3I6</accession>
    <name>M3B3I6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_39664</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762453.1">
        <property type="nucleotide sequence ID" value="XM_016908755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B3I6"/>
    <dbReference type="MEROPS" id="S10.016"/>
    <dbReference type="GeneID" id="27905892"/>
    <dbReference type="eggNOG" id="KOG1282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008523_10_3_1"/>
    <dbReference type="OMA" id="RCPWNGA"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF189">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta-Hydrolases"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004031683" evidence="7">
        <location>
            <begin position="20"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF14332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="620" mass="67773" checksum="6499130A33F3570D" modified="2013-05-01" version="1">MGFLSLCVACGGLAILAHAGFPSTPQGLTIKQVTSKPGVSISYKETTICETRSKGYAGYVHIPSAHLDDSGDGDSYNISIFFWYFEARKRPRTAQTAIYLAGGPGISSMFGVTLSGGPCTVLPDSNSTESNPWAWNEHVNMLYVDQPVGTGFSYDALINGTKDLLYNGAGDFYDVTPLDAYDGLPPRENLTTRYGTFSSDNAMHTANSTANAARTLWQFAQTWFVEFPRYKTSDKRISFWGNSYGGYYAPFSAAYFQEQNVKIKSGALAAHVLPVSTVGWTNGCVDMLYQAEWYPQMANNNTYDLHILPDDVYAAAKESWSTENGCRDQILACREAGNAYDPDGYGNNISVNQLCLAAEYYCAANIVLLPFSSSTTRSALDFAHLSPDPSPPLYLLGFFNQAWVQKELGVPLNFSSTSYLVYNNFIAGTADAFRAAGLKKIEYLLNQKINVAMIYGDRDYRCPWNGAEKLSLAANWTAAHAFRSAGYADIKTGDCGNNVGAVRQRGHFSFSRVFQAGHDAAFAQPRTTFEIFTRTMLGYDVATGKHLVDDRYTTKGPRDTWHIRTPLPQLPPAFSCNIYAVSTTCTAEQYEALSAGTAVIENSTVIWPIGGTPGNLAGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M3B487</accession>
    <name>M3B487_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Multiple RNA-binding domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_148267</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM MRD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762723.1">
        <property type="nucleotide sequence ID" value="XM_016904816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B487"/>
    <dbReference type="STRING" id="692275.M3B487"/>
    <dbReference type="GeneID" id="27901953"/>
    <dbReference type="eggNOG" id="KOG0110">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008479_0_0_1"/>
    <dbReference type="OMA" id="FNNTCIQ"/>
    <dbReference type="OrthoDB" id="439639at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034462">
        <property type="term" value="P:small-subunit processome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd12565">
        <property type="entry name" value="RRM1_MRD1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Multiple RNA-binding domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051945">
        <property type="entry name" value="RRM_MRD1_RNA_proc_ribogen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN 14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039:SF5">
        <property type="entry name" value="RNA-BINDING PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="4"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="306"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="489"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="601"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="702"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="77"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="245"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="567"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="572"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF14602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="828" mass="91930" checksum="0BDAC4DC36734302" modified="2013-05-01" version="1">MASSRIFVKGLPPTFDEAQFRKHFGQKGQITDAKIFPNRRIGYVGFKTSEDAQKAVKYFNKTFIRMSRIGVEIARPIDESPASRRNPTAKVTGANEQPLAENNQLKRKRDTDSKPHEDAAKEDPKLKEFLDSYKSKSDKKALVADAMAHPIAMAENDETAVIIEAGASDDEYEQVPKKAKRTTSIPKPVHEDSMPDAPVEVVVAEPAGNIEQQPEASGKMAMTDDEWARSRTSRLLGLLDDEDEEISHAKQDDSDSDTEVVRPSRAETRLSTPAPEPRSSIPTPPAEEEREDDVPDKDIEAVRSTMRLFVRNLSYDVSYEDLEAEFSSFGNLEQIHIPLDKTTGSSKGFAYVQYTDPDSAEKALVDRDGRTFQGRLIHILPATAKRENKIDEFELAKLPLKKQQEIKRKREAANTVFNWNALYMNQDAVISSVATRLGLAKSEVLDPTSSDAAVKQAHAETHIIQETKSYFRQQGVDLDSFKKSARGDTVILVKNIPADCSRDELRRLFDEQGDVKRFLMPPAGTIAIVEYGNAAQCKAAFGTLAYRRVKSSVLFLEKAPKDVFSAKPVDEQSAQSTPEGVSKLSTSELKDSTVADTAGSATLFVRNLNFSTTTSLLTETFKPLDGFLNARVKMRTDPKRGQLSMGFGFLEFQTPKHAQAALQAMDGYSLEGHKLQIRASHKGEDAAEKRKQADKAKKAATTKVIIKNLPFEATKKDVRALFGEYGQLRSVRVPKKMDRGARGFAFADFTTVKEAQSAMDALKDTHLLGRRLVLDFAEEDPEDAEKEIEKMQQKIGAQVNKVALQKLTEGGKRKKFTAAGQQDGEDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M3B4P9</accession>
    <name>M3B4P9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_132365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762893.1">
        <property type="nucleotide sequence ID" value="XM_016902488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B4P9"/>
    <dbReference type="GeneID" id="27899625"/>
    <dbReference type="eggNOG" id="ENOG502T62T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060605_0_0_1"/>
    <dbReference type="OMA" id="MYPLETA"/>
    <dbReference type="OrthoDB" id="5342184at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021986">
        <property type="entry name" value="Spherulin4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35040:SF9">
        <property type="entry name" value="4-LIKE CELL SURFACE PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14080)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12138">
        <property type="entry name" value="Spherulin4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF14772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="282" mass="30963" checksum="BF78034FE5D5A063" modified="2013-05-01" version="1">MVVYANFLFPLYIYPLNNAWNPLFTAATQYPDITFTAIINPSNGPDSSTITNCPNKDFIEALNSLHQFPNIHTLGYVHTANLYNCGSSGSDICPCTAPADEVKRNISMYAAWATARCEGWSTLAPEVYVDGIFIDESPGEDAGACLDYMTDLTTHAKSTLTTKTGGSVFFNAGAATEMAYFDIADVIIILENTQAVYEAIPDIGVRNGNGKYARKSSILIYEAGNDTGLIQRDVETILSVERDGFHSMFYSDRAVDQYSNFPYAWKEIVEQVNVVAQKNKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M3B5G2</accession>
    <name>M3B5G2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_79242</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763138.1">
        <property type="nucleotide sequence ID" value="XM_016910216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B5G2"/>
    <dbReference type="STRING" id="692275.M3B5G2"/>
    <dbReference type="GeneID" id="27907353"/>
    <dbReference type="eggNOG" id="ENOG502QVCU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022730_0_1_1"/>
    <dbReference type="OMA" id="WNRNLML"/>
    <dbReference type="OrthoDB" id="429143at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF279">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="2">
        <location>
            <begin position="34"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF15017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="452" mass="49276" checksum="C07A7929FCCAACDA" modified="2013-05-01" version="1" fragment="single">MAVPVANATQSFWRSDPQPLDNHRTTEQLPAKADIVIIGAGYAGASITHHLLEKSKALGRSVSIVILEAREACSGATGRNGGHLKPDPYNRAAGALKTHGKEAAEEVASFEARQVKEVQKLVERENIECDFVVTRATDVCMYEGARKDLKQGLDALTEANVSTASEVHYSDTRTAQGVSGVKGAQGCFTYTAAHVWPYKLVLSLLNKAVKHGVNLQTHTPVTSVQPALEPHTWAVETSRGSIAAEKVIYASNAYTSSLLPEYKTKIIGVRGICSRIVTTKPNAPFLSNSYILRLAPNEYDYLIPRSDGSIIVGGGRRDYFHQLETWYENYDDSSLITSAQRYFDGYMQRHFRGWEDSGAYTDAVWTGIMGYSADGFPHVGAVPGKAGQFICAGFSGHGMPQIFLSAKALAEMALEGKEVEEVDLPKLYRASQARLDSKMNVALEGWDGTHAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M3B5X7</accession>
    <name>M3B5X7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">PQ-loop-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_147152</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-histidine(out) + L-arginine(in) = L-histidine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71063"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the laat-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763343.1">
        <property type="nucleotide sequence ID" value="XM_016904117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B5X7"/>
    <dbReference type="STRING" id="692275.M3B5X7"/>
    <dbReference type="GeneID" id="27901254"/>
    <dbReference type="eggNOG" id="KOG2913">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019699_3_2_1"/>
    <dbReference type="OMA" id="NDRLEWI"/>
    <dbReference type="OrthoDB" id="8048523at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034488">
        <property type="term" value="P:basic amino acid transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000009">
        <property type="entry name" value="PQ loop repeat family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF34">
        <property type="entry name" value="LYSOSOMAL AMINO ACID TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="184"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="406"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="190"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="406"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF15222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="446" mass="48892" checksum="5FB210D99F618BCE" modified="2013-05-01" version="1">MQWIRPSALEPSLPAYCTPENDFLLHFSSTFHTCVPTPLAFTSITLGGLSILAWLFAQLPQIYKNWSIQSTSGLSIFFLAEWCLGDISNLLGALFTRQASWQICIGGYYVFVDLCLVGQWIWYERLRHGHPVLRMWKRKNTNDGDSSTSGGMEQVVIEGTDGVTKAPSRPKIIFRTLTFQREENEKEKLASSSGTSRNSNTIHKVGPSSPMPSPSPRTMLLIACMIAISHASPISKTSVVHSHLHDSGGPTALEKAGTIISWMSTVLYLGSRLPQLFKNWQRKSVAGLSPHLFLAAFCGNMFYSLALLSNPNAWNDFGPHGGGGWVDKDGSDRTQWVLAALPFFLGAAGVLGLDASVGVQFLLYGETQEKLVVAEEQQQQQQGGARYRWRRVSGWLRGWIPSGVGSISSRPTSSSSSSPSSEHTALLVNDGDDGRRQQHGEGYGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>M3B7A6</accession>
    <name>M3B7A6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="7 11">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SEPMUDRAFT_60913</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 10 11">Belongs to the peptidase C12 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="7 11"/>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763863.1">
        <property type="nucleotide sequence ID" value="XM_016909546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B7A6"/>
    <dbReference type="STRING" id="692275.M3B7A6"/>
    <dbReference type="MEROPS" id="C12.009"/>
    <dbReference type="GeneID" id="27906683"/>
    <dbReference type="eggNOG" id="KOG2778">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018316_1_0_1"/>
    <dbReference type="OMA" id="YIQYEIQ"/>
    <dbReference type="OrthoDB" id="1924260at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019784">
        <property type="term" value="F:deNEDDylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071629">
        <property type="term" value="P:cytoplasm protein quality control by the ubiquitin-proteasome system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09617">
        <property type="entry name" value="Peptidase_C12_UCH37_BAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.532.10:FF:000009">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017390">
        <property type="entry name" value="Ubiquitinyl_hydrolase_UCH37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041507">
        <property type="entry name" value="UCH_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF16">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE ISOZYME L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18031">
        <property type="entry name" value="UCH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038120">
        <property type="entry name" value="Ubiquitinyl_hydrolase_UCH37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 10" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 10" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="13">
        <location>
            <begin position="3"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="302"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 10">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8 10">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="9 10">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR038120-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038120-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMF15742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="324" mass="36743" checksum="FAE80798233EFFD6" modified="2013-05-01" version="1">MSGWNTIESDAGVFTYLIESLGVQKVQFEELISLDPEALQQLNPIGVIFLFKYPTDQKPKRDTPRDGEFDYAALENQDEPLWFAAQTIQNACGTQALLSVLLNKDNKEDGGVEIGQNLKEFKEFTASFPAEFRGEALSNSDLIRETHNSFARSSPFVSDETRLATADDDVYHFIAYTSINSTLYELDGLQPAPIRHGDAGACPPEIFSDAVIPVLQRRIERYPQTEIRFNLLAICEDLRSRAREVGDEEWLAREEQKRRDWQWENALRRHNFVGFIGELTKGVAGKKLKDGTYDKWIEDAKSATKKRVSDHEKRGQGGDDMDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M3BP97</accession>
    <name>M3BP97_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_136827</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF07988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756109.1">
        <property type="nucleotide sequence ID" value="XM_016902804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BP97"/>
    <dbReference type="GeneID" id="27899941"/>
    <dbReference type="HOGENOM" id="CLU_602914_0_0_1"/>
    <dbReference type="OrthoDB" id="3637592at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032020" description="Extracellular membrane protein CFEM domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="402"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF07988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="454" mass="49027" checksum="99BCF679A72B033F" modified="2013-05-01" version="1">MRLITVSAAAALVVSSSVVAESVSTAQLSVVEGGARECTLCLEHAASQTQCEASDSSETNFDFECLCLKTAFRIITRGCSGFCEGTQYSLESQCRLDNGTPRNAIDRRAAFVEGDARSCNLCLEQAARQTYCVNNNSSISGYDFHCLCKEPGFSEYTEGCTDFCRATEYDIEIQCSKIRECPVCNIDEVRKCERCLEDTSSTTTATTSCNLAPDADISGLFESANIEFTAAACTEFCIAILEAQCSLSQMTLSPRTAQLQTSNPGFGFCGPKGTNCKSTESAHSSSSSSSSHHSPPSPPIKPLMNRKQQQQQHQHQHHKDHKHSRSANWPHHSGAQTASGIFGFCGVSGSNCRAEENKQQQQQQETTTSTTSSSSDATVTTMTAMTTMMAIQIPSSRTAATTATTATATATPVIHPTSKNPKTTTTTTNPISNETNSPSPQNRRQRRRTRNLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M3BRH2</accession>
    <name>M3BRH2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_136104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756844.1">
        <property type="nucleotide sequence ID" value="XM_016902753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BRH2"/>
    <dbReference type="GeneID" id="27899890"/>
    <dbReference type="HOGENOM" id="CLU_2198640_0_0_1"/>
    <dbReference type="OrthoDB" id="206088at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF08723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="108" mass="12279" checksum="B3BCA42479D7D424" modified="2013-05-01" version="1">MIESRSRRGCISSWSSGTRRSHSHHRILQPFDACYNLHSRSTHQHKTPSQQKCSSTPSLPSWQPLPPPMLGPLLFPLRSQRPLLRPSLRDTTAGTVVIGPSTNRRRFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>M3BU57</accession>
    <name>M3BU57_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidyl-prolyl cis-trans isomerase-like 1</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_151206</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758331.1">
        <property type="nucleotide sequence ID" value="XM_016906671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BU57"/>
    <dbReference type="STRING" id="692275.M3BU57"/>
    <dbReference type="GeneID" id="27903808"/>
    <dbReference type="eggNOG" id="KOG0882">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_31_0_1"/>
    <dbReference type="OMA" id="GMVEYWR"/>
    <dbReference type="OrthoDB" id="10264753at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01927">
        <property type="entry name" value="cyclophilin_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000003">
        <property type="entry name" value="Peptidylprolyl isomerase domain and WD repeat-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF4">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE DOMAIN AND WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0697">Rotamase</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="90"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="134"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="10">
        <location>
            <begin position="503"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="468"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="468"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF10210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="650" mass="72367" checksum="ED16A62D01E6E5F1" modified="2013-05-01" version="1">MAAAQAEHALGSPSPPPPPSQGTKRSHHQSEQHQNDNDNDNDNANASSDSDDDLGPALPSAEAPRKKRRRLPYERQHVAALPSATRYARSLMHRDQLSACTFTPHTDFLVTTSVDGYVKFWKKTSGAIEFVKEYKAHDGDIKSVTVSADGRSYATAGLDNTIKIFDVATFDLLAMLEPRKPPKAICFVHGHGTSFPLLAVSNEADGGINIYDGRGENPDPMHTIASLHRHSVHIMTYNNAYDCVLSADESGMLEYWQPSAPFGKPSNVWDMKSATNLFDFKKAKAVPSSISISPSGEQFATFSFPDRKVRIFHFATGKLHRTYDESIATINDMQQAGTLSATPLDAIEFGRRMAVERELDHPALRSRFNVIFDESGHFILYGSILGTKVINTFSNRLVKLYGRDEPFRPLHLALYQGQPDKKAFTTVQMAASENPLLAEAAARDAMLVATGSGKVRFYMFTNDDGVSKSDRDIHNEKPRTIGTNKKKEEAEREANMGTTATIHTTMGDISIRMFPQHAPKAVENFTTHSKNNYYNGIIFHRVIRKFMIQTGDPLGDGTGGESIWGKEFEDEFTPELRHDKPYMVSMANAGPKTNASQFFITTERAPWLDDKHTIFGRVVKGMDVVHMIENVKVWKEKPVDDIKIVNISVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M3BUT7</accession>
    <name>M3BUT7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Synaptobrevin homolog YKT6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_150121</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759225.1">
        <property type="nucleotide sequence ID" value="XM_016905976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BUT7"/>
    <dbReference type="STRING" id="692275.M3BUT7"/>
    <dbReference type="GeneID" id="27903113"/>
    <dbReference type="eggNOG" id="KOG0861">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074848_0_1_1"/>
    <dbReference type="OMA" id="HYIGIIR"/>
    <dbReference type="OrthoDB" id="27923at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033106">
        <property type="term" value="C:cis-Golgi network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016409">
        <property type="term" value="F:palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061909">
        <property type="term" value="P:autophagosome-lysosome fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15867">
        <property type="entry name" value="R-SNARE_YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000020">
        <property type="entry name" value="synaptobrevin homolog YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045848">
        <property type="entry name" value="R-SNARE_YKT6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806:SF1">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Longin" evidence="11">
        <location>
            <begin position="7"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="137"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF11104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="197" mass="22367" checksum="9FA118647677AE17" modified="2013-05-01" version="1">MKILYIGILRNESKPAVELAAERDLTSFSRFTRSNVGEFLTVFAKTVAERTQPGQRQDVEEQSYTFHSYARSEGCCGIIISDHEYPKMVAHQLLSKVLDEFLSRYPRSAWADSNGEVPFPVLEEYIVKYQDPQAADSIMKIQKELDETKIVLHKTIESVLERGEKIDSLVAKSDGLSAQSKMFYTQAKKQNSCCVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M3BV75</accession>
    <name>M3BV75_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_150211</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759350.1">
        <property type="nucleotide sequence ID" value="XM_016906022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BV75"/>
    <dbReference type="STRING" id="692275.M3BV75"/>
    <dbReference type="GeneID" id="27903159"/>
    <dbReference type="eggNOG" id="ENOG502RNZ1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015940_0_0_1"/>
    <dbReference type="OMA" id="WAYGETL"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007817">
        <property type="entry name" value="Isocyanide_synthase_DIT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37285">
        <property type="entry name" value="SPORE WALL MATURATION PROTEIN DIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37285:SF5">
        <property type="entry name" value="SPORE WALL MATURATION PROTEIN DIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05141">
        <property type="entry name" value="DIT1_PvcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="3">
        <location>
            <begin position="504"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="22"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF11229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="667" mass="74590" checksum="DC788F2EEB2E2ACA" modified="2013-05-01" version="1">MPGRSISVDERDIEVEAPRAPLKAVSHATPSEAAHEVKPTTTETLVDGPTDDNRALASRIFAIIKRYKLRPNEEEVPEANARFIDQISAKISASEPILMCLPAFPFKSPNTSLKVLGTLPDKAEEFALAHMNGMCAAITQIYTPGAGLMIISDGLVYNDLLGVPDSSVWAYGETLRSMAVEKGFNHIQFSRLKDLAHINIPDQLDQIKYISNATNFRHALLSQFGNPNFDASAKIHEDDDTCLTYRGYIKFLMTDLQDVYPVGTSMSKSQYKKGVEYVAKQMLFRGDAFASAVKATFSHYIRLSIHPSNASSDKKISISPLPTDTSFSTPWHCCIAFRLDGTTTTGHRADFEADDRYELVHENGKPSFFREKTDLLSWGQERGGIDCEPLYPAGLMIRPRAGANALSIKDVDGPKLRALAQLNSPVILRDFAQTRDRELFVQKSYDLGAPTSWKFGLVLEVKDAGSDSRGLNNVLSAEWMPYHYDGLFKTEKRSLPDGSEELVSTPPRFQLFTSVTKSPPNTGYTLFSSSTLVFRHLPKDLPVERLRNLTWNVSTASFNATKLRGLPLVVDHPATGQPCLRFHEPWPQSRTAFEPTHIEIENAGDDEKWDSEAICNALTDVLHDRRVAYWHSWQKGDLLVSDNILAHHTRSDFNAGSDRELWRIHFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M3BVH1</accession>
    <name>M3BVH1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_126890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759440.1">
        <property type="nucleotide sequence ID" value="XM_016902110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BVH1"/>
    <dbReference type="GeneID" id="27899247"/>
    <dbReference type="HOGENOM" id="CLU_1187489_0_0_1"/>
    <dbReference type="OrthoDB" id="3649267at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF11319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="234" mass="25220" checksum="C9BB6ACC19755CE3" modified="2013-05-01" version="1" fragment="single">MLDDACVQAIRSAAETYAERLILNRHATALHNDSQLSQSCPEIAHMINADPPEECGPYFSANTTWYDAAALTDSQSSPIYHGCQAQADDDDDTTTTASKHGDDHHSSPWWSLNSAKNSYSNQIYDLVVTHVSPVLMIWVSVSNPSTSTSTTQPNTKPPSTATATSTALLKCLRPKTISPGSRAPAVLPAPEPVVPFSQDKNKQDGESSDGSKSKSTDDDDAAKKDKKKKSKKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M3BW36</accession>
    <name>M3BW36_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial genome maintenance protein MGM101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_13448</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
            <location evidence="1">Mitochondrion nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGM101 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759655.1">
        <property type="nucleotide sequence ID" value="XM_016902647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BW36"/>
    <dbReference type="STRING" id="692275.M3BW36"/>
    <dbReference type="GeneID" id="27899784"/>
    <dbReference type="eggNOG" id="ENOG502RXU4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028692_1_1_1"/>
    <dbReference type="OMA" id="INWETSW"/>
    <dbReference type="OrthoDB" id="17164at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000262">
        <property type="term" value="C:mitochondrial chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009446">
        <property type="entry name" value="Mgm101"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31404">
        <property type="entry name" value="MITOCHONDRIAL GENOME MAINTENANCE PROTEIN MGM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31404:SF0">
        <property type="entry name" value="MITOCHONDRIAL GENOME MAINTENANCE PROTEIN MGM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06420">
        <property type="entry name" value="Mgm101p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1135">Mitochondrion nucleoid</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF11534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="202" mass="22952" checksum="3ACFE37EB81F88D7" modified="2013-05-01" version="1" fragment="single">SPSDESQPLHSLTDGLQDPPPILNENEKQVDWTRSYHGLSSTPFTPEQAAILQEPLELDDIEIKPDGIVYLPEIKYRRKLNRAFGPGGWGLAPRGETIVTGKLVTREYGLVCGGRLVSIARGEQQYFDPDGIPTATEGCKSNALMRCCKDLGIASELWDPRFIRKFMKEMAKETLVEHVVTKRRRKHFMRKDDELKYPLKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M3BXH8</accession>
    <name>M3BXH8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_108241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760902.1">
        <property type="nucleotide sequence ID" value="XM_016900727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BXH8"/>
    <dbReference type="GeneID" id="27897864"/>
    <dbReference type="eggNOG" id="ENOG502R9A7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_845113_0_0_1"/>
    <dbReference type="OrthoDB" id="3641195at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF12781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="329" mass="37306" checksum="35E7560152E0137F" modified="2013-05-01" version="1">MPLPTNMKHLLNDGLPGERPPKRHSTSPPSLPTFSSPLTPAPADEMEDRTVIATHSTPPKSISEHYTYFSEQGKDSTPTETRSGHMASLVSTECEAEDSQGQGEPETEIEADLLGELQTADNYMEVMEPVLPEEPSRAQTPTTSVSQSLRDYCKLMYGKLYVPLQDLTYPDECRLHPEHKDELFDAFLENVTVIVTVWTNYDGLLKQFFGEHEKPRFQDCGKVYLSPEQRTRLEMMDNANGFEMKNVQLNIGTPFRTFFTLYFQHDGEKKVLVNGEVFDYYGLGAPHKPLFDLVVQNMEECSNYEQWFGKAGLNLTDLDNIARLFLGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M3BZV3</accession>
    <name>M3BZV3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Isy1-like splicing factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_148838</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SO2202</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2012-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genome evolution in poplar pathogens from wild and recently domesticated pathosystems.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Dhillon B."/>
                <person name="Feau N."/>
                <person name="Sakalidis M.L."/>
                <person name="Gill N."/>
                <person name="Aerts A."/>
                <person name="Ohm R."/>
                <person name="LaButti K."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Copeland A."/>
                <person name="Beauseigle S."/>
                <person name="Grigoriev I.V."/>
                <person name="Goodwin S.B."/>
                <person name="Tanguay P."/>
                <person name="Hamelin R.C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ISY1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761712.1">
        <property type="nucleotide sequence ID" value="XM_016905179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BZV3"/>
    <dbReference type="STRING" id="692275.M3BZV3"/>
    <dbReference type="GeneID" id="27902316"/>
    <dbReference type="eggNOG" id="KOG3068">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043453_2_0_1"/>
    <dbReference type="OMA" id="YHWERRI"/>
    <dbReference type="OrthoDB" id="1739576at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.660:FF:000001">
        <property type="entry name" value="pre-mRNA-splicing factor ISY1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009360">
        <property type="entry name" value="Isy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037200">
        <property type="entry name" value="Isy1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13021">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ISY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06246">
        <property type="entry name" value="Isy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140102">
        <property type="entry name" value="ISY1 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF13591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="242" mass="27847" checksum="E4B6BBB2D62A4113" modified="2013-05-01" version="1">MARNAEKSQSMLFRFRAQQAADLGIVDINRTKRPKAISQQENIQTCERWRGQVLKEISRKVSKIQDLALSDFQIRDLNDELNKLFKEKWQWEMRIRELGGPNYMRGGGKVTDDEGRVIDGGGKGYRYFGRARELPGVKELFEAATQKPEKEVKEARQDLRLRVDASYYGYNLDEEDGTLLRYEAQKEQEAFEALASEADTADGDFEPLPGDAGDGVLWKLPTAEEVETELLERRKRKLLDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M3C013</accession>
    <name>M3C013_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Protein ROT1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_125384</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Required for normal levels of the cell wall 1,6-beta-glucan. Involved in a protein folding machinery chaperoning proteins acting in various physiological processes including cell wall synthesis and lysis of autophagic bodies.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ROT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761782.1">
        <property type="nucleotide sequence ID" value="XM_016901976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C013"/>
    <dbReference type="STRING" id="692275.M3C013"/>
    <dbReference type="GeneID" id="27899113"/>
    <dbReference type="eggNOG" id="ENOG502QQTG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071622_0_0_1"/>
    <dbReference type="OMA" id="YKPPQML"/>
    <dbReference type="OrthoDB" id="5327821at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006458">
        <property type="term" value="P:'de novo' protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019623">
        <property type="entry name" value="Rot1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28090">
        <property type="entry name" value="PROTEIN ROT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28090:SF1">
        <property type="entry name" value="PROTEIN ROT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10681">
        <property type="entry name" value="Rot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017290">
        <property type="entry name" value="ROT1_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004031522" description="Protein ROT1" evidence="12">
        <location>
            <begin position="21"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="229"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR017290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF13661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="254" mass="28493" checksum="AF57D8A15650A726" modified="2013-05-01" version="1">MLRILALAAAGLSVFTSTTAQTLPADIVGTWSSKSNSTLTGPGFYDPINDKFIEPALTGISYSFTADGYYEEAYYRAIANPTRPTCPGGIMQWQHGSWQQNANGSLSLTPIGVDGRQLMSTPCEYSHAVYTRYNQSEQFKQYQVLVDPYHNIKRLNLWQWDGTPMQPLYIAFDPPQMLPTTTLHAQVTAKETGKSKRGLDSSPEVPLNWKSKYEQHTGYMVQRINPDRLWWIGLGFTGIGGLLYFGPRRLGLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M3C156</accession>
    <name>M3C156_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_115319</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762147.1">
        <property type="nucleotide sequence ID" value="XM_016901151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C156"/>
    <dbReference type="STRING" id="692275.M3C156"/>
    <dbReference type="GeneID" id="27898288"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022195_0_2_1"/>
    <dbReference type="OMA" id="NFMAALE"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF6">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE AN1598-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF14026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="510" mass="57704" checksum="22809FC8E12863E1" modified="2013-05-01" version="1">MAPQALLMSERFSFFFSGITLGPVLGLLTLPFLALYWFLKKPKGFDVDVPLLTNESEDFMEILQEGYTKHPRSLFKIPTSNKPMVIVPTNMLDDLKAYPEEAISFRKEMSDRFLGRYTSVASNSEAMIQSVKSNLTRGLDSVIPIMQEEVKYALEECIENETMDAEGWVKAPLYALSVRIIAFVSSRVFVGLPLSRNQEWIDMAINSTFDSFVGAAVMYKYPSWSWAIMRFFVPQTRRIQQCRRRVGEMLKPILKERMEHAKNNPGSKKPSDMIQWLIDNSNGRGGDLPFQANEHIVMNVAATHTTGGQLAHTLCALAQHPEYIPILREELQEALKNLKAGENLNKKTLFQLKKMDSFMREVQRMNPPGMVSANRKALQPIKLSNGVIVPTGTSLATLPACVSMDPKIWKNPNEFDGLRFYNLRLAEGEEKYQFVSVNEEALSFGHGRHACPGRFYAAAELKVVLAEILSTYDIKLCEGYSKSRPLGAWMEIMAAPDHTYELCFRKRAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>M3C370</accession>
    <name>M3C370_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="14">SNF2 family helicase/ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SEPMUDRAFT_148359</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762852.1">
        <property type="nucleotide sequence ID" value="XM_016904871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C370"/>
    <dbReference type="STRING" id="692275.M3C370"/>
    <dbReference type="GeneID" id="27902008"/>
    <dbReference type="eggNOG" id="KOG0385">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_0_2_1"/>
    <dbReference type="OMA" id="VHDYQFF"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031010">
        <property type="term" value="C:ISWI-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17997">
        <property type="entry name" value="DEXHc_SMARCA1_SMARCA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000036">
        <property type="entry name" value="Chromatin remodelling complex ATPase chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000082">
        <property type="entry name" value="ISWI chromatin remodeling complex ATPase ISW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000022">
        <property type="entry name" value="ISWI chromatin-remodeling complex ATPase CHR11 isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000234">
        <property type="entry name" value="ISWI chromatin-remodeling complex ATPase ISW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.30:FF:000003">
        <property type="entry name" value="ISWI chromatin-remodeling complex ATPase ISW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.30">
        <property type="entry name" value="ISWI, HAND domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044754">
        <property type="entry name" value="Isw1/2_DEXHc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015194">
        <property type="entry name" value="ISWI_HAND-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036306">
        <property type="entry name" value="ISWI_HAND-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015195">
        <property type="entry name" value="SLIDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF49">
        <property type="entry name" value="SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09110">
        <property type="entry name" value="HAND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09111">
        <property type="entry name" value="SLIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101224">
        <property type="entry name" value="HAND domain of the nucleosome remodeling ATPase ISWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="185"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="481"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="13">
        <location>
            <begin position="848"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="111"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="752"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1023"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1023"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1067"/>
            <end position="1080"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMF14731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1095" mass="124809" checksum="4320DE09D9DDD9AF" modified="2013-05-01" version="1">MASSSALGAGDGSLPDAVMLDTPDYTDSESNPTGANSVVGDAPRDGRSRRWEGNSLRKSMLGKKHERLGDNKEDDSIKRFRYLLGLTDLFRHFIDTNPNPQIREIMQEIDRQDQEDAERQQAGNKRKGGAAGDRRRRTEKEEDAELLRQGKQEGKVAHTIFRESPQYIQGGEMRDYQVAGLNWLISLHENGISGILADEMGLGKTLQTISFIGYLRFTQGITGPHLVAVPKSTLDNWKREFAKWIPEINVLVLQGAKDERQELIQERLVDEKFDVCITSYEMILREKSHLKKFAWEYIVIDEAHRIKNEESSLAQIIRVFNSRNRLLITGTPLQNNLHELWALLNFLLPDVFGDAEAFDSWFNNQDADQDAVVQQLHRVLRPFLLRRVKADVEKSLLPKKEVNLYVGMSEMQIKWYKSILEKDIDAVNGAAGNKESKTRLLNIVMQLRKCCNHPYLFDGAEPGPPYTTDEHLVDNAAKMVMLDKLLKRMHAQGSRVLIFSQMSRVLDILEDYSVMRGYKYCRIDGSTAHEDRIAAIDDYNKEGSEKFIFLLTTRAGGLGINLTSADIVVLFDSDWNPQADLQAMDRAHRIGQKKQVHVFRFITENAIEEKVLERAAQKLRLDQLVIQQGRAQQQAKAAASKDELLGMIQHGAETIFESKDGYGAFGKGGAADDDLDAILRHGEERTKEIASRYEKLGLDDLQKFNTEAGAAYEWNGESFIPKKKEIGLSWINPSKRERKEQSYSMDKYYRNALATGGPRPDPKPKVPRAPKQQSLHDYQFFSPRLGDLQEKETAFFRKENGIKAPLADGDEDTLDQRTQDQELEQKNIDDAEPLTEEEIAEKDQLAEEGFGDWNKRDFQQFVNGSAKYGRNDYDGIALEVDSKNAKDVKEYAKVFWKRYKEIHNWEKHISAIKEGEQRAARVIEQRELLKKKLAMYRVPLQQLKLNYTVSTTNKKIYTEEEDRFLLVMLNKYGIDTEGLYEKIRDEIRESPLFRFDWFFLSRTPQEISRRCATLITTVTREMEGGKENKRVVEEEDEEDEEAPAKKKGRTSTGGAKNKAVNGIKGTPNGTSRAGSVDTNASGGGPSKAKSRSRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M3C5D0</accession>
    <name>M3C5D0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycoside hydrolase family 2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_60316</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763582.1">
        <property type="nucleotide sequence ID" value="XM_016909520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C5D0"/>
    <dbReference type="STRING" id="692275.M3C5D0"/>
    <dbReference type="GeneID" id="27906657"/>
    <dbReference type="eggNOG" id="KOG2024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009935_3_1_1"/>
    <dbReference type="OMA" id="PQCGSPF"/>
    <dbReference type="OrthoDB" id="408320at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051913">
        <property type="entry name" value="GH2_Domain-Containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42732">
        <property type="entry name" value="BETA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42732:SF2">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032311" evidence="4">
        <location>
            <begin position="21"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolases family 2 sugar binding" evidence="7">
        <location>
            <begin position="122"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="5">
        <location>
            <begin position="240"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 catalytic" evidence="6">
        <location>
            <begin position="363"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF15461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="651" mass="73068" checksum="5BCC8BC99288B7A6" modified="2013-05-01" version="1">MQIFRISPATFLLILGSALGHIPLHFARQSQNATQPYQLQTPPLDTVYTSQVGLTPWPQHPRPKLRRKEWKSLNGIWQWTNATSLEDVNNPPFGQSLAREVLVPFCLESALSGIQGERLLYSWYRTTFDVPAYWSGDRVLLNFDAVDYEATVFVNGQNVTFNRGGYFAFSVDITDHLEAGDANELVVFVHDPTDSDANVIPIGKQTLEPSHIFYTSCSGIWQTVWLESVPFDHVSSLDIDGDAYGNLTIKAMTSGNVTSAVSVTVYEKNTTIVVATGTGQSNSAFGLMVENARLWSPETPTLYDVSIKSANDTIQSYTGFRTISRGSVNGVQRVLLNGASYFPFGTLDQGYWPDGIYTPPTYEAMVYDLEVLKTIGFDMLRKHIKVEPPLFYEAADRLGLLVMQDMPSLRPSQTRTLQNCTRETILPDDAQQAEFQRQLEILVTQFRSYTSIFSWVIYNEGWGQLTTQPYPEFQLTDFVKSLDPTRLVNSNTGWYDHGAGDFSDNHHYANPQCGTPWYSIASSPFDPSRIGFQGEFGGTGHNVSAKNLWKVEEALDTINQTYEIDQTLDIWNRRGHFLLSELLSQVEMYSCAGGVWTQTTDVEGEVNGMLTYDRRIIRPHVPQWRTDIQALYAASAARSNETAPVFEPAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M3C6L2</accession>
    <name>M3C6L2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cullin binding protein CanA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_124057</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAND family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763997.1">
        <property type="nucleotide sequence ID" value="XM_016901877.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.M3C6L2"/>
    <dbReference type="GeneID" id="27899014"/>
    <dbReference type="eggNOG" id="KOG1824">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007157_0_0_1"/>
    <dbReference type="OMA" id="AYIPHFQ"/>
    <dbReference type="OrthoDB" id="6260732at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010265">
        <property type="term" value="P:SCF complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039852">
        <property type="entry name" value="CAND1/CAND2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013932">
        <property type="entry name" value="TATA-bd_TIP120"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12696">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08623">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25782">
        <property type="entry name" value="TPR_CAND1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="TATA-binding protein interacting (TIP20)" evidence="5">
        <location>
            <begin position="1126"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="366"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="465"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="366"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="465"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF15876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1313" mass="142705" checksum="8516F27729F5329E" modified="2013-05-01" version="1">MASNTVPQNPTSHNVASLLSKLQDADSDIRYMTLNDLNQMLINGHQTFLQHDYNTCAKVVEGLLHTLNDSHGEVQNMAIKVLGPFVNKVPEPILCPTIEKVSNIKTDNSIDNSIPAIAVRAIVVALPHPSPGLPRSQKVNEAYNAVSKALIPRLVGRVVIPLPKPGPPPPKGMLQYDLETGNDSNSLDLLHAVAVNFGPMLQMVEVEALEQVTMSIVESEKCGTVMKKKAVAALSALAPYFDDRLLANHISYTIEQLRQSHLTSQQRRLFINVYGSLARSIPKQFGPYLRTLAPFVLAPLSQEELEQQREAEAESDGERDVQLEEVRESALVAIAAFLESCPADMRPYTKDVAEAATRFLKYEPNVLDDDDEDMDEEEEETADDFDADEDFEEEAGFEDEDDVSWKVRRDSAKTLYALIGMLDPKEPSIYGQIAPALINRFKEREESVRTEVIKTLAFLITKTGASAAPSTPDSTSLSRKRRRGFSDSLGSDLETQQALMNGYASPSTLAPTDATKSLAKINPEIVKGASKLFKSSTPATKQALISLLKDMVIAQHGGLSDSADLVIAPVVDIINTAASSGSNLSNNAVRIEALVLLRAIAETHPTKVIQPHLDIIIPAVIKSATDRLAKVSGEAFTTIEAYIKALTPPRSSLANNGDVLTKLFGIITNRITAPESDTEVRQKAVQALGLLIGRTSGAATALLSEKDRFAGQEIIAERMKNELTRLTCVRAIDTMAVLAQSPTDFKPGFVGAVALELGAQLRKSSRSLRGASLSALRMLAVNQASRESIVDDAIVVKLIDMFIPLLMSGDLHMIGPALIVLASFTKGRPEAVATDAVIAGICSIVRSPLSGSALDALIACVESIGEAGVGRQLMTALLDIAPAGDTDVTGQVIGTLLVSGGDSVGVKLDSFIQELRTQTDEAKRCLALSVLGEAGLRQSTQSALKPESFTPYFADQSEKVKLAAAVALGRAGAGNVKSYLPKILDGMAQGRQYLLLHSVKELLQHSTAEDEIRPYTKSLWENIINSGQAEDNKVVGAECVGRLAIIDPTAYLPQLHTFLQNPNSTVRGMVIAALRYVFSDTEPSYNPHLQATIIPLLSTMLRDTDLDNQRLSLTTFNSALHNKPALVLPHLGELLPYAIQASVIRPELIREVSMGPFKHKIDDGLEIRKSAYETLYALLDSPASRERLDISAYYERIVAGVVDEHEIRILCCLVLGKLLTIAPHESARRLDSLAAQFRAVLSFKPKENAVKQELEKITEQQKAVVKVSVAFNKAFGEGIGQESRVWKEYFDYAKRDFAPAVKFAEDESRNASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M3C9J1</accession>
    <name>M3C9J1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_166911</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756611.1">
        <property type="nucleotide sequence ID" value="XM_016908270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C9J1"/>
    <dbReference type="STRING" id="692275.M3C9J1"/>
    <dbReference type="GeneID" id="27905407"/>
    <dbReference type="eggNOG" id="KOG0590">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_59_8_1"/>
    <dbReference type="OMA" id="ACIKKAC"/>
    <dbReference type="OrthoDB" id="539158at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051598">
        <property type="term" value="P:meiotic recombination checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000692">
        <property type="entry name" value="Serine/threonine protein kinase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895">
        <property type="entry name" value="CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895:SF32">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="19"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="332"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF08490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="580" mass="63228" checksum="1AA4A3D64AD5F80E" modified="2013-05-01" version="1">MGGPPGSQAAPLPANLPFRIVSKTIGSGAYASIRKAIPPNSSGPVIAVKFINKDHAFRAGRLRPKQLLIEISVHAHVSSHPHIIKYIAHGEDPAWVWLALELADGGDLFDKIEADSGVGEDVAHFYFTQLISAIAWCHGKGVAHRDIKPENVLLSGDGDLKLADFGLATQFLDLKSGERKTCGMVCGSPPYIAPEIIEVGKVNQKRKSRNDDKLGYDPAVADVWSCAIVLFVLLVGNTPWDSPVMEESYEYHEYVTTKGRSTDELWEGVPAEALSLVRGMLSVEPEGRFTMESVRRHPWFTRSNPHLNSKGRVKDPISLATQMMESLKVDFSAGVQSSQRRRAPVASSQGANMDTDRHKPNWAQLASTQPETPISDTSAFDWETPPRLGAGNGIPASQPQTNDDRIAAVAAHTSIAARKGEPTPTNLHALFSEDPSMSQFSATPTVPLTLTQVARKFNHIVPSHSLTRFSSLLPFSQLLPMLLSALHRLNIPVATPAASALEGKEDVVSIWVKTLDANKLPIQGQVVVERIRVGGTELGVVEWEFLETRFLKLKGDPLGWRRLFKQVAVLCKDGVFGAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M3CA03</accession>
    <name>M3CA03_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zinc finger H2C2-type histone UAS binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_151669</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756811.1">
        <property type="nucleotide sequence ID" value="XM_016906970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CA03"/>
    <dbReference type="STRING" id="692275.M3CA03"/>
    <dbReference type="GeneID" id="27904107"/>
    <dbReference type="eggNOG" id="ENOG502QRFX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_42_5_1"/>
    <dbReference type="OMA" id="KQHAGIN"/>
    <dbReference type="OrthoDB" id="10264707at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052742">
        <property type="entry name" value="Mito_N-acetyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015416">
        <property type="entry name" value="Znf_H2C2_histone_UAS-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43138">
        <property type="entry name" value="ACETYLTRANSFERASE, GNAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43138:SF2">
        <property type="entry name" value="PROTEIN SPT10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09337">
        <property type="entry name" value="zf-H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zinc finger H2C2-type histone UAS binding" evidence="2">
        <location>
            <begin position="309"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF08690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="524" mass="57432" checksum="B7F111BCE3B1EAD7" modified="2013-05-01" version="1">MPAMLDDPTAPAIYRISGQQPFPEPFGALPHEISPKQVTLRDRTTIATLVPFSSPNQVPPHLTAYLCELLNREIEKGDTYPMIDGMALSSFAAYWFANFGAIMVVGDISTPEEITHMEEQGVDWAKLCLGSFYVKPNYPGRSSHICNGGFLVTDGARNRGVGRLMGEVYLEWAPKLGYTYSVFNLVYETNLASLRIWDALGFKRIGRVKGAGNLKSYPGTMVDAIIFGRELGGENEEYQSEERFDKIRYYLKSGAYPAGSDRAEKSRLRSAATHYRLIPGNGEEDKLMLKGKEVVSDPHKQYEIARAMHAQTHGGINKTTAGIAEKYHWVRIKETVSAAIRNCAECKESLTPKHAGAISPSTGGASARRGPLAGPKKSTPVVARQIVPVSPDVGLTNTITGPPSSESSQQAQHMVHSSQRDNQQVHQQLDQELLQHAVPTARMGGIVDYQDGSSADYGDTGPVDPQLMWQTGHDDQSMQIDSDDKTGNTEDDGESHLREVLGAHAMAGEIQSFLGEAAQRQENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>M3CBV5</accession>
    <name>M3CBV5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_151001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF09897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758018.1">
        <property type="nucleotide sequence ID" value="XM_016906534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CBV5"/>
    <dbReference type="GeneID" id="27903671"/>
    <dbReference type="HOGENOM" id="CLU_1950172_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="129" mass="14016" checksum="56EF82C1E879F74F" modified="2013-05-01" version="1">MRIKSVTQYRLSSLQPPRCSSAISQIQTNDPSPRSLLPLRTCILSPTTSASESSGMWYLLRHVGNLAQTSSSIQTQHELLRIGTHISGGPAARTISEPSADFMSAPPQAPTRQAGAASVCRKRSQRDKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M3CE10</accession>
    <name>M3CE10_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_134451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759392.1">
        <property type="nucleotide sequence ID" value="XM_016902645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CE10"/>
    <dbReference type="GeneID" id="27899782"/>
    <dbReference type="HOGENOM" id="CLU_1939458_0_0_1"/>
    <dbReference type="OrthoDB" id="434647at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004031919" evidence="1">
        <location>
            <begin position="18"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF11271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="130" mass="12810" checksum="52A393F64A7AA47F" modified="2013-05-01" version="1">MALLKYAIAVLPAWSSAAVIAPQADNSSACYTTTIFAVVASSENTTPAATNSSSSSTTLPMMVTGVNATGTGGAAHATNINNGTSTWAPTVVTPTIAPAPSDGAAADELSTSLMAAVVAFGGLTWAFAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M3CHB2</accession>
    <name>M3CHB2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Palmitoyltransferase</fullName>
            <ecNumber evidence="11">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SEPMUDRAFT_148560</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DHHC palmitoyltransferase family. PFA5 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="11"/>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761309.1">
        <property type="nucleotide sequence ID" value="XM_016905000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CHB2"/>
    <dbReference type="STRING" id="692275.M3CHB2"/>
    <dbReference type="GeneID" id="27902137"/>
    <dbReference type="eggNOG" id="KOG1315">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034009_0_0_1"/>
    <dbReference type="OMA" id="SFYTKDV"/>
    <dbReference type="OrthoDB" id="331948at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF23">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="52"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="13">
        <location>
            <begin position="124"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="254"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="406"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="300"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="446"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMF13188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="478" mass="54142" checksum="0AAB45813EDEAA8F" modified="2013-05-01" version="1">MAATNRVSVGAARVIPILLVLIVGYASYVVVGPLCISYLIHPPRGTPRRLLAGILIIVFYFVLLIPVAISWLRLLLAVLIEPGYTQRGDSDLQRPTVTEPPLEGLETFWMRDVFVCDQNGLPIWCDVCKCPKPDRTHHNQDVGRCTRKMDHFCPWVGGVVGERSYNFFVQFLFYTMVFTAYITGVLGYYVAGYKHNVHWFVVLGLAGFFLLFTAGMVMNSLNMVFKNTTTIEAVRGRMYLAVILPPEMQRDPLVPPPPAVLSQTPGDGASDEGSERHLTSELDDPAHISYFKRQSKPTRRQSTSHSSTPSKLWKGTITYPLRLPTDRPPIPAPEPRTFAILETPRGLNPWDLGTAMLNFRAVFGHHFYEWFLPLRHSPCCEHSSQISEYPLGPEFEVLLVDAGLVRPATSSSQKNERRGSSTPSRRKKRRLDEGWQNGERPNGWVSEKEARRIRNEWRRRVNQADHPFGGGRQPDDVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M3CHJ7</accession>
    <name>M3CHJ7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">3,4-dihydroxy-2-butanone 4-phosphate synthase</fullName>
            <shortName evidence="12">DHBP synthase</shortName>
            <ecNumber evidence="3 12">4.1.99.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_148619</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18457"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="4.1.99.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="12">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="12">Binds 2 divalent metal cations per subunit. Magnesium or manganese.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">Belongs to the DHBP synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.12" evidence="3 12"/>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761384.1">
        <property type="nucleotide sequence ID" value="XM_016905036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CHJ7"/>
    <dbReference type="STRING" id="692275.M3CHJ7"/>
    <dbReference type="GeneID" id="27902173"/>
    <dbReference type="eggNOG" id="KOG1284">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020273_3_1_1"/>
    <dbReference type="OMA" id="DAGGLIC"/>
    <dbReference type="OrthoDB" id="60371at2759"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008686">
        <property type="term" value="F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.870.10:FF:000002">
        <property type="entry name" value="3,4-dihydroxy-2-butanone 4-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.10">
        <property type="entry name" value="DHBP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000422">
        <property type="entry name" value="DHBP_synthase_RibB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00506">
        <property type="entry name" value="ribB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327:SF18">
        <property type="entry name" value="3,4-DIHYDROXY-2-BUTANONE 4-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327">
        <property type="entry name" value="GTP CYCLOHYDROLASE II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00926">
        <property type="entry name" value="DHBP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="YrdC/RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0318">Glutathionylation</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 12" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0686">Riboflavin biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF13263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="227" mass="24363" checksum="435807417408361E" modified="2013-05-01" version="1">MATANGDVSFDSIPDAIEAFANGDFILVMDSTDRENEGDLIIAAQDLTPAKAAFLIRYTSGYLCAPIVPALAARLELPQMVTENSDPNRTAYTITIDAAEGVTTGISAQDRSLTCRRLADPAVQKDWFRRPGHVVPLQAREGGVRVRAGHTEAAVDFCKLAGKEPVGVIAEMVEDGEYVAGKAEMSGGFGMMRRDGCLAFARRHGLKAVTIEDLVKYLDSGEGKIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M3CIK6</accession>
    <name>M3CIK6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_155895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761769.1">
        <property type="nucleotide sequence ID" value="XM_016907647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CIK6"/>
    <dbReference type="GeneID" id="27904784"/>
    <dbReference type="HOGENOM" id="CLU_2185596_0_0_1"/>
    <dbReference type="OrthoDB" id="2501249at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF13648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="109" mass="11875" checksum="ECA9C763EF3C6715" modified="2013-05-01" version="1" fragment="single">MRPAVSLSSPPTVCLGIKHARAEDLVHSISVQWRAEQTILFQSLISHDGESINDEQAGVRTVGGSSGNGRFNLQGIVCIIAEDEKSLRRRQREAAYGLHMMHRGPANGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M3CLS0</accession>
    <name>M3CLS0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ZZ-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_148366</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762859.1">
        <property type="nucleotide sequence ID" value="XM_016904877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CLS0"/>
    <dbReference type="STRING" id="692275.M3CLS0"/>
    <dbReference type="GeneID" id="27902014"/>
    <dbReference type="eggNOG" id="KOG4351">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4582">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007590_0_0_1"/>
    <dbReference type="OMA" id="NKHGHHP"/>
    <dbReference type="OrthoDB" id="661148at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14947">
        <property type="entry name" value="NBR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02249">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02340">
        <property type="entry name" value="ZZ_NBR1_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032350">
        <property type="entry name" value="Nbr1_FW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20930">
        <property type="entry name" value="OVARIAN CARCINOMA ANTIGEN CA125-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20930:SF0">
        <property type="entry name" value="PROTEIN ILRUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16158">
        <property type="entry name" value="N_BRCA1_IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="6">
        <location>
            <begin position="378"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="732"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="859"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="736"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="872"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="906"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="953"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="973"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="990"/>
            <end position="999"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF14738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="999" mass="109935" checksum="12E72F8ED3C84079" modified="2013-05-01" version="1">MDATHNTGVVSQDTLIIIKISVNEQLKKLKLPLRDLGASVLPDKLRRVLDIKPEQHVVLERFSDSAGGYITLDQTNPQVFKTLIRAAKAKGKLRLKATVSSVAAPENKEAGELKVAPKEMAPLIASPSRDSVSLDKRSIGSGIFQFRDARNSQQTLVNDEAPVPRPFFDQSAYFDKLAAPTVPNKLASLVLRPREPDETSKKCSDEYSVFCNVCGVATPDTHYHCSICNDGDYDLCDKCVSDGKLCPGENHWLIKRFPYNGGYVQSTTTRISNAAPLKLESGVEEQKKETSDTFIDDTKVLSSDTRTPTRTCNSCVVVLPEREFVTCSDCDDYDLCISCFSTVEKSGHHPAHSFKPSTHETVLPFSAQSNLAPGRNVRHNAICDGCDQPICGVRHKCLTCPDWDYCNECVKTARQSHPRHRFAALYEPIGDQGISMVRHYGIYCDGPLCSKKVTQSFINGVRYKCTICHDTDFCASCEALPGNHHNRTHPLIKLKTPVRHVSVSTENEDRCGQIRLMGDRGSASVNIPVTAPSPVQTVAEIKPSEIKAESAPIAIPVKKYQASAPVPAQSVQPKSDIPLTVLDARFVRDTISDGMVVEPETRFTQVWTMKNPGPYPWPSGCSVRYVGGDNMLDVDNSHPSSVAAINDATESNIVGREVAAGEEVAFKVIMKAPLREGKCISYWRVKAADGTPFGNRLWCDIEVKKAPQAVVSIAPTVPALAGVPQMPRCQVRPCGSRTSLPLQSVRSSQPPTPSEQPPAYSSTESMNLSSRLVAMREQQKQRREHMLAQLSAQREQLQAQGIKREEVPMRGPVNQLNGQQMGKDALRQRVAYIKANIQKTREEREKLRAEHSELQAAAVERKAEVQAEDEISGAKKVDEEVPKHLDAENGLERSQMVFPKLDKESPSSSTHESATNSAHKGKAAYVENEDGEVERSATPDRASGPVVHSPSVDEYDFAEIDDELEVLSANGVDSEDDGFMTDEEYDILDASDHETVASY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M3CMC3</accession>
    <name>M3CMC3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_114063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF14933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763054.1">
        <property type="nucleotide sequence ID" value="XM_016901074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CMC3"/>
    <dbReference type="GeneID" id="27898211"/>
    <dbReference type="HOGENOM" id="CLU_2172660_0_0_1"/>
    <dbReference type="OrthoDB" id="3349449at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF14933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="110" mass="11080" checksum="61586D0EBCAE0053" modified="2013-05-01" version="1">MCPQGCAWRIVDCQGTLDAIANSMSSTSSGSESLASANGQVLISAHSPSSSSSSAAAAAAAAADYACKRVLSTQVAVVVISADLGRPGPGREDARRSFGDETRNVTVEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M3CNF1</accession>
    <name>M3CNF1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Peroxisomal membrane protein Pmp47</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_147235</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763434.1">
        <property type="nucleotide sequence ID" value="XM_016904165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CNF1"/>
    <dbReference type="STRING" id="692275.M3CNF1"/>
    <dbReference type="GeneID" id="27901302"/>
    <dbReference type="eggNOG" id="KOG0769">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_6_3_1"/>
    <dbReference type="OMA" id="QFMMYEL"/>
    <dbReference type="OrthoDB" id="2019556at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015217">
        <property type="term" value="F:ADP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080122">
        <property type="term" value="F:AMP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005347">
        <property type="term" value="F:ATP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015228">
        <property type="term" value="F:coenzyme A transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015230">
        <property type="term" value="F:FAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044610">
        <property type="term" value="F:FMN transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051724">
        <property type="term" value="F:NAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000119">
        <property type="entry name" value="Mitochondrial carrier domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000152">
        <property type="entry name" value="Mitochondrial carrier domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052217">
        <property type="entry name" value="Mito/Peroxisomal_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939:SF5">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="17"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="112"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="224"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF15313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="319" mass="34646" checksum="D3CFDC3F55A2A780" modified="2013-05-01" version="1">MSQKESAAQQTTAEQQSDNVAHALAGAGGGLLSMALTYPLITLSTRAQVEKKKASTGTLDAAKRIIDREGVVGLYAGLDSALFGITVTNFVYYYWYEFSRAFFQRSTGKKQLSTLESMAAGALAGSATVLLTNPIWVINTRMTARKNESTETLPLQEGEKRQVNTAQPGTISTLLKIIREDGFFRLFAGVLPALILVMNPILQYTIFEQLKQALEKRRKVGPTDSFVLGALGKLAATSITYPYITVKSRAHVASKDAKKQGMIATLKQIYHEEGTAGLYGGIGPKVTQSVLTAAFLFAFKDALYDMTIKARRSVAAKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M3CP46</accession>
    <name>M3CP46_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_105797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763674.1">
        <property type="nucleotide sequence ID" value="XM_016900592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CP46"/>
    <dbReference type="GeneID" id="27897729"/>
    <dbReference type="HOGENOM" id="CLU_667591_0_0_1"/>
    <dbReference type="OrthoDB" id="3633551at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF15553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="412" mass="45695" checksum="32322EAD76FA5026" modified="2013-05-01" version="1">MSDLQWEPRDHRHNRSYSIAASTRSEVATRHSRFSWWQIMDQRARDRISIGDDARPSLDASSSDATHTRPETSTRTDASDDVASLFEPRINLHDDWSTPPTSAVPPSPSNIFPAALIPCKSAASTGAFATFTGNLVNPQLPWGSQSALSPVNLLPLQQTRARKPDIRQNALARKSASSGMLYQTYQAEDRLVDRRDRLRSEVRALRHKTSLLDETLKQTVHQRLALHEERDAMSLASSSPIVPALDPKVTIMDRGRTVPRSDCSAADSVLWQASAPSAFGMAAKTNGQPKPKRPVLSLDIQAAQATMGVQRKPYQVRQNSNISIAPHIVSISKTRPTNATPRSADPALRRSTSLPAFTELPSRAQTSTMTKYDHKALRKTQNLYNKLTEGNTRGSASHKITGLWKNVRMRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M3CR40</accession>
    <name>M3CR40_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_25974</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF16138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764259.1">
        <property type="nucleotide sequence ID" value="XM_016908401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CR40"/>
    <dbReference type="STRING" id="692275.M3CR40"/>
    <dbReference type="GeneID" id="27905538"/>
    <dbReference type="eggNOG" id="ENOG502SHQF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_0_4_1"/>
    <dbReference type="OMA" id="FRVWWRC"/>
    <dbReference type="OrthoDB" id="5329176at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="3"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF16138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="255" mass="27913" checksum="2119E31A13B43CB9" modified="2013-05-01" version="1" fragment="single">SSDIGADDWVALAAALGSTIGCLLILISANQALGRHTSYATPAQVESVLLLIWLDQINYLIVMALAKTSTLLLYTRIFHGEQQRRFRLVCWFTMAVVGLTSVLLMIFSVIMCRPVEYFWTRVHLLVVPGIDETAAAAAGGKCKDNRPYLYANTVISIVTDMVIVVLPIRQIVGLQMARKKKVTVCALFGLGMIVIVCSIMRATKVEDAANATDPMVNLSGLCVWSLVESAVSVICCCVPASHRLIRDFFVDLFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M3CVU6</accession>
    <name>M3CVU6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450 71D7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_93736</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756383.1">
        <property type="nucleotide sequence ID" value="XM_016910625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CVU6"/>
    <dbReference type="STRING" id="692275.M3CVU6"/>
    <dbReference type="GeneID" id="27907762"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_0_1"/>
    <dbReference type="OMA" id="NIWHAYH"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF232">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF08262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="524" mass="59741" checksum="7BE14A94EDB4BC15" modified="2013-05-01" version="1" fragment="single">MLALIVSVARRLCALLISLVTSIVLYRLFLHPLANIPGPKLAAISNVWYAYHARNGRMLHLGKTLHQIYGPMVRVGPNEVWFNSKEAFSKIYSATQGYEKSDFYLATALNRPKFDRWWNLRFPDSLDLLSERDMERYRLQRRTIGPLYSMHNIQKYEAAIDDVLIKVVAQLQGLHSAPVDLKMWMHIITVECLSAAVLSYSPGYLKAKSDYGSSSHAYLNWRRKSVFGLFTWAVLAESHFKASGRCFSSVWRLTFRTPAPFRPFFTSVYSKITKRITAALRPKPQRDDRTDLMADLIQLHMDKPEFSLTYLKRMAMTNFGAGHETTTSALISAVSMIASRPGARDRVRAELPRPTSHGNTMILPYAHAAGLSYTQAAIKEAQRLYPVLGMSPSRAVPSGGLYVHDTYIPQGTRVGCNPVSLHRNWEIFGDDAEEYRPQRWLPEDDDNKNNNNNTRDMERYNLTWGGGARTCPGRNLAQLILYKVVPTLFQNFHVEVDVPLDENITYYFMAMLTGVQVRFLPRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>M3CW15</accession>
    <name>M3CW15_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_121779</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456312">
        <property type="protein sequence ID" value="EMF07876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016755997.1">
        <property type="nucleotide sequence ID" value="XM_016901728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CW15"/>
    <dbReference type="GeneID" id="27898865"/>
    <dbReference type="HOGENOM" id="CLU_1994040_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF07876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="102" mass="11848" checksum="B7FB27BB2ADB4984" modified="2013-05-01" version="1">MPKRKNVTPEALENKRTRLGAAAKSLKEYSLKPNTLRDRERTAAIDEEKRAQDRHRKACNESFVRFKKAQIKQSSEFSELTEYDRKAAKKQVETDLALLPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M3CW87</accession>
    <name>M3CW87_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TT1751-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_121187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756523.1">
        <property type="nucleotide sequence ID" value="XM_016901665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CW87"/>
    <dbReference type="GeneID" id="27898802"/>
    <dbReference type="eggNOG" id="ENOG502SUWP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105954_1_0_1"/>
    <dbReference type="OMA" id="TMLRHDV"/>
    <dbReference type="OrthoDB" id="5190258at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14797">
        <property type="entry name" value="DUF302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.70">
        <property type="entry name" value="TT1751-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005180">
        <property type="entry name" value="DUF302"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035923">
        <property type="entry name" value="TT1751-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03625">
        <property type="entry name" value="DUF302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103247">
        <property type="entry name" value="TT1751-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF302" evidence="1">
        <location>
            <begin position="75"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF08402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="172" mass="18938" checksum="34F57790B4960F48" modified="2013-05-01" version="1">MSGTRTETTYQTTRITRTYAKPFDKVLERLHSSIKKPSVGAGGLSILDDLSSKEAFESVTNAALGPHGFMQFQQFNHGDWMSLYGVNRGRKVVRIIFGNPQIAITMIRHDVGAALFVPVEVLIIEREDGKTDVVQVKPSTLIAGAEGSSGELKTAAEILDDKLEKLWEFVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M3CWS3</accession>
    <name>M3CWS3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NPP1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_74880</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Necrosis inducing protein (NPP1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF08126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756247.1">
        <property type="nucleotide sequence ID" value="XM_016910084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CWS3"/>
    <dbReference type="STRING" id="692275.M3CWS3"/>
    <dbReference type="GeneID" id="27907221"/>
    <dbReference type="eggNOG" id="ENOG502S1MP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062263_1_0_1"/>
    <dbReference type="OMA" id="AHGGWDC"/>
    <dbReference type="OrthoDB" id="89086at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008701">
        <property type="entry name" value="NPP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33657">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33657:SF8">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05630">
        <property type="entry name" value="NPP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029958">
        <property type="entry name" value="Necrosis-inducing_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032050" evidence="3">
        <location>
            <begin position="19"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF08126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="239" mass="25084" checksum="B34856A2D64D6033" modified="2013-05-01" version="1">MLFSATTALLGLAATVLSAPVIGIQKRAVIAHDAVVGFAETLPSGVTGTLYLKYKPYLKNDNGCVPFPAVDAAGNTGGGLAPSGSSSGSCSSNTGQVYARAGSYNGAYAIMYSWYWPKDSPSDGLGHRHDWESIVVWISEASTTATLQGVAASAHGDFDTTTTPNLMSGTSRPLIRYYNVWPVNHQLGFTSTVGGQQPLIAWESLPSAARTALENTDFGDANVPFKDSNFQNNLAKAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M3CXZ9</accession>
    <name>M3CXZ9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_120822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SO2202</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2012-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genome evolution in poplar pathogens from wild and recently domesticated pathosystems.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Dhillon B."/>
                <person name="Feau N."/>
                <person name="Sakalidis M.L."/>
                <person name="Gill N."/>
                <person name="Aerts A."/>
                <person name="Ohm R."/>
                <person name="LaButti K."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Copeland A."/>
                <person name="Beauseigle S."/>
                <person name="Grigoriev I.V."/>
                <person name="Goodwin S.B."/>
                <person name="Tanguay P."/>
                <person name="Hamelin R.C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757048.1">
        <property type="nucleotide sequence ID" value="XM_016901636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CXZ9"/>
    <dbReference type="STRING" id="692275.M3CXZ9"/>
    <dbReference type="GeneID" id="27898773"/>
    <dbReference type="HOGENOM" id="CLU_1897518_0_0_1"/>
    <dbReference type="OrthoDB" id="5405791at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF08927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="134" mass="15007" checksum="BA27AAB3C0C634B0" modified="2013-05-01" version="1">MSEARAARKRLDKRICPTNGRLDEKIGTLPRSTTRTPIALKGLPTPLTRPVSSTFGPRLGEPFNFATKPEKLDSTFKLDHEQDALDDMFLHEGSAFMEAAELESCLNEHEVHTSIENDLDITMMIRSDGYEADT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>M3CY75</accession>
    <name>M3CY75_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ketoacyl-synt-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_159092</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF09017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757138.1">
        <property type="nucleotide sequence ID" value="XM_016907825.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.M3CY75"/>
    <dbReference type="GeneID" id="27904962"/>
    <dbReference type="eggNOG" id="KOG1202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_6_0_1"/>
    <dbReference type="OMA" id="YCRGDGC"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.366.10:FF:000002">
        <property type="entry name" value="Probable polyketide synthase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000011">
        <property type="entry name" value="Sterigmatocystin biosynthesis polyketide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.110:FF:000001">
        <property type="entry name" value="Sterigmatocystin biosynthesis polyketide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000031">
        <property type="entry name" value="Sterigmatocystin biosynthesis polyketide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030918">
        <property type="entry name" value="PT_fungal_PKS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04532">
        <property type="entry name" value="PT_fungal_PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF37">
        <property type="entry name" value="SI:DKEY-61P9.11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22621">
        <property type="entry name" value="CurL-like_PKS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="9">
        <location>
            <begin position="369"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="10">
        <location>
            <begin position="1291"/>
            <end position="1601"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="1675"/>
            <end position="1752"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="1814"/>
            <end position="1891"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="6">
        <location>
            <begin position="1291"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="6">
        <location>
            <begin position="1454"/>
            <end position="1601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1642"/>
            <end position="1677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1752"/>
            <end position="1814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1655"/>
            <end position="1664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1752"/>
            <end position="1767"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="6">
        <location>
            <position position="1323"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="6">
        <location>
            <position position="1514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF09017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="2190" mass="236791" checksum="B20BD5B0C1987930" modified="2013-05-01" version="1">MSNILLFGDQTAEQYPLLHKVTLHRDNVLVSNFVQRSALALREETRALPRSQRDAMPDFLTLTSLVEAYYQKGEKVPMLESALVTIAQLGHYIGYFSEHPDELPATSNTRVLGLCTGLLAAAAVVSARTIDELVLLGVDFVRVAFRSGAAVDGIRSVLAQPGQEKTPWSAIVTGTTQEDAKLALSAFHEEKGIPLSNQAYISAVSVMAITISGPPTTLERFFKESALSENNRVAIPIYGPYHAPHLFHEADLERILSGNVGLELKQHVPSALVHSAATGKPLVAENSFELAKTALREMLQSPVRWDYLLEEVVSQMAASRLPAKIYALGVSNIANSLVTALKAGGKTEVSVIDQSAFTESTEYNGRTQNDKIAIVGMAGRFPNSANHEALWDLLMKGLDVHRKVPADRFDADAHCDPSGKGKNKSHTPFGCFIDEPGLFDPRFFNMSPREAAQTDPMGRLALVTAYEALEMSGYVPNRTTSTKLNRIGTFYGQTSDDWREINAAENVDTYFITGGVRAFAPGRINYYFKFSGPSYSIDTACSSSLAAIQLACTSLWAGDCDTACAGGLNVLTNPDIFSGLSKGQFLSKTGSCKTYDNDADGYCRGDACGTVILKRYQDAVADKDNILGCILGAATNHSAEAVSITHPHAGAQEFLYKQVLANAGVDAHEISYVEMHGTGTQAGDGIEMTSVTNVFAPRHRQRRPDQTVHLGAIKANVGHAEAASGVNSLVKVLMMMKNNKIPANVGIKGVMNKTFPADLKDRNVHISQQQVDWPRKTAAPRRVFLNNFSAAGGNTALLIEDGPLREAPKAVDPRSTLPITISARSIASLKRNLSHYQQFVRENAGTTLTSFSYTTTARRIQHNYRVAFSLADASKLVDSLQGQVKDTYSPVPMVATKVAFCFTGQGSQYTGLGQKLYQDLKSFRDDIDQLDQLARIQGLPSFLELLDGTDVQTLSPVKVQLGMACIQVALARMWASWGITPSAVVGHSLGEYAALHVAGVISASDMVLLVGRRAELLVRDCTPHTHGMLAVKGSADAIRTALGPKMTEIACINGPEETVLCGSGDVVGTANEILARCGFKATKLNVPFAFHSAQVDPILEQFTKVASAVTFNKPVVPVLSPLEGQVIRDDGIINPTYLARHAREPVNFWSALISGQSATVFSEKTAWLEIGAHPVCSGMVKASIGATVTAPSLRRGEDAWKTISNSICQLYTAGVNINFDEFHREFNDAQELLTLPTYSFDNKKYWLDYHNNWTLTKGEAAQIKEVIREKEVAAPAPVVEVPAKRLSTSCQKVISEEFSETSAKVVIRSSLADNKLYPVVCGHLVNNAALCPSSLYADMALTVSDYIWKETHPESETPGLNVCNMEVPKPLIAQIPQPAQGQHVEMEAVADLENNTVKVNFRSVQPDGKKIQDHAHCIVRYEDKAAWAGEWARYNFMVNAQIDTLTAKTMTGGAHKVQRGMAYKLFKALVTYDSRYRAMSEVVLDGKTTEASATIDFPTKPDDGDFYCSPYHIDGSCHISGFIVNASDLLDSEQNVYVSHGWSAVKISKPLTAGMRLRNYVRMLPQPNNISKGDVYILEGDEIVAVCEGIKFQQIPRRVLNTFLPPNKGSAAPQAQRSIAPKPAARPLLTRSPLPAPVKVAPAPVRKTAPPPPAAVAAPASRSVSKPKKVAPPKKPSGGLVDKIMQILAKETEVDVAELVDDAHFENLGVDSLLSLTISAIFREELDIEISSSLFTDYPSVGEMKKYFAGLDASSSGSNSSSSSSAPDYDEDSDSDSNPATDVPTPLEDISTPASSAPSIMGKPAPDSPTRDSLAEVGDVSIARHVVAQEMGVDIEEITDDADLSELGMDSLMSLTILGELREKTNVDLPSTFLSTNPTMADIENALGMRPAPKTAAAPRSAAKTSTQTDMNEVSARLGAINKTDISRYPAATSVLLQGNAKIATKKVFFLPDGSGSATSYVSIPNLGPDVAAYGLNCPFMKNPDTWDCGIEVASLIYLAEIKRRQAKGPYIIGGWSAGGVIAYAVAQALLAAGEKVEKLLLLDSPCPVNLDPLPARLHIFFNEIGLLGTGDPSKTPKWLLPHFSAAIRSLSAYDPKPTLRPIPTYAVWCKEGVAGNPGDPRPPPAEDEDPAPMKWLLNHRTDFGDNGWAQLCTGPFKNGVMNGHHFSMMKEPHAKELGKLIREGLDWRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M3CYD1</accession>
    <name>M3CYD1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_120603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756817.1">
        <property type="nucleotide sequence ID" value="XM_016901619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CYD1"/>
    <dbReference type="STRING" id="692275.M3CYD1"/>
    <dbReference type="GeneID" id="27898756"/>
    <dbReference type="eggNOG" id="ENOG502TAP9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_685433_0_0_1"/>
    <dbReference type="OrthoDB" id="3363286at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF08696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="402" mass="45544" checksum="A60D116AD89FE0BA" modified="2013-05-01" version="1">MQHVMFQRRLPTRHAASAVSKILSRLSGHRNVSRAVPEGSVGTSRISPSEPTTLSEDGIRTLRIRKHGHKPLPIPEIMDPIYLHARNKHKQPRQVIIGYRRLDVGQGRHQDREEEEEAEDGPRRDASDVRDLKPIQDSKTMTPFQIKLHTNPYARALATSIRQCVLTRARLPSHFLLQFGLFMPQVEESPSSQQSDDVKPYWKLLAYPQRSPMKLPLGRVRATRSTVEALASKQRNGGRWGVLASQKARDRWAVMTPRAGSGGILPGKEFDWDPNMSEVVLQRLREEVVTKMRYGLECGLVKKRRDGEENEEVLAVLKLKGGVEEVHDLGESSSMAGEMGTSNGPIAGWIKYNLTKLFEADELKEFMDDDLDIEMDELVVFKDRTNMSLLLALEQLQNYVGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M3CYH2</accession>
    <name>M3CYH2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_159170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF09127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757248.1">
        <property type="nucleotide sequence ID" value="XM_016907827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CYH2"/>
    <dbReference type="STRING" id="692275.M3CYH2"/>
    <dbReference type="GeneID" id="27904964"/>
    <dbReference type="eggNOG" id="ENOG502S1B6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_602913_0_0_1"/>
    <dbReference type="OMA" id="SYQCTLR"/>
    <dbReference type="OrthoDB" id="5210591at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="408"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="454" mass="51009" checksum="86B8777D438BB8AC" modified="2013-05-01" version="1">MSVALLERSVVSSPPEISIDMRNMSTLANPAAARTSTPDRKSLQRIAAEALHTKSVAIDRIHGTLFRNYKLQPSSHAAATTTTEETFYILKCRPSSPAIRLLRHEEDRLRTEAYTLQTLLLLLHSSSSTKSSEMPSTRMIPRLIASSPHHHHRTNTTTTPIDPSPYIITGPFHGHLLSEISPQLSQTPSEKIQQRVGFFYRNLTISFSPFSSSSSTTQQPQTKPFGPLYPPSSSSSSSSELSRFTTWSQFYTTLLETLLLDAEDALINLPYAFIRETVRRNRNSLDRITKPKLVFLEGLIDERNILVQRRRLESSSGAGERRRSEDEWEISGILDWSGVIWGDEWMSDGFYDHFSKKGSMGGFLEGFLGGKGQRQNQRRSGEEVVRQYLYILYHSLLAIIRQCYRPSSSSSSSPSPSNSNSNTTNSESQQTELAARRDLTNALTQLSKICTSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>M3CYR0</accession>
    <name>M3CYR0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome regulatory subunit 6B homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SEPMUDRAFT_151732</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756922.1">
        <property type="nucleotide sequence ID" value="XM_016907007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CYR0"/>
    <dbReference type="STRING" id="692275.M3CYR0"/>
    <dbReference type="GeneID" id="27904144"/>
    <dbReference type="eggNOG" id="KOG0727">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_2_0_1"/>
    <dbReference type="OMA" id="QDIGGMD"/>
    <dbReference type="OrthoDB" id="10255768at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045899">
        <property type="term" value="P:positive regulation of RNA polymerase II transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000020">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000049">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000033">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 14" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="197"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMF08801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="420" mass="46892" checksum="F5F11FB008AA6873" modified="2013-05-01" version="1">MASADVSKAPTAPHLLNQISSSAIANIDTIEGLTDSDDQYATYKKLQRQLEYIKLQEEYIKDEQRSLKRELVRAQEEIKRIQSVPLVIGQFMEAIDQNTGIVQSSTGSNYVVRILSTLDRELLKPSSSVALHRHSNSLVDILPPEADSSIAMLGADEKPDVTYADVGGLDMQKQEIREAVELPLTQFDLYKQIGIDPPRGVLLYGPPGCGKTMLVKAVANSTTASFIRVVGSEFVQKYLGEGPRMVRDVFRMARENSPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQTSNVKVIMATNRADTLDPALLRPGRLDRKIEFPNLRDRRERRLIFSTIASKMSLSPEVDLDSLIVRNDPLSGAVIAAIMQEAGLRAVRKNRYNIIQQDLEDAYTSQVKGASEADKFDFYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M3CYU3</accession>
    <name>M3CYU3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_151748</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756952.1">
        <property type="nucleotide sequence ID" value="XM_016907019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CYU3"/>
    <dbReference type="STRING" id="692275.M3CYU3"/>
    <dbReference type="GeneID" id="27904156"/>
    <dbReference type="eggNOG" id="ENOG502RYTK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063296_0_0_1"/>
    <dbReference type="OMA" id="ANPRYPM"/>
    <dbReference type="OrthoDB" id="445556at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050817">
        <property type="entry name" value="DjlA_DnaK_co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24074">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DJLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="84"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF08831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="335" mass="37689" checksum="BCDF5C0C1F120FAD" modified="2013-05-01" version="1">MILITPPQYSALFAVAHHSVPRATRSISTTSSNRRTQGSTRPTAWRGHGYATMAGDVGGVGEQSDGRDTAYTWPETPKGHAHPTPYQIFNMRHDGQYSKAGYYKLVKMYHPDRHVHTVGSTRDASEISHATKTERYRLIVAAHTILSDPVKRSAYDRFGAGWNGKAEVGGKETWSQPSPFHAAGPFSQSWHDPADPVWKNATWEDWERYHDHKANPTKKAPVYMKNSYFLAVVIALSIIGSSFNVQRAQDNGTYLVEARDLVHDRAAKNLRQVKKEVQGLTSRQDRIDFFIRQREASLGGSVSDYQTLRDERAERLLKDREVCSSEEVKESGSDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>M3D0Y4</accession>
    <name>M3D0Y4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_151177</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758274.1">
        <property type="nucleotide sequence ID" value="XM_016906650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D0Y4"/>
    <dbReference type="STRING" id="692275.M3D0Y4"/>
    <dbReference type="GeneID" id="27903787"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012538_2_0_1"/>
    <dbReference type="OMA" id="IALEQTW"/>
    <dbReference type="OrthoDB" id="3648608at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="17"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="60"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF10153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="609" mass="69368" checksum="48102D1E6FE41CB9" modified="2013-05-01" version="1">MAARAARARGRNGSLAVVCDFCSRSYSRRDALRRHQPVCPDRGSRPVDSSARPRGRARHSCDRCVDKKLHCDGRKPCGTCVVKSAICSNITSRDGPSRSASQDPEARVQRHRSESFLLRDEEEEVFSARFNFPRPPTAEQALQEHEHEHAHAHAHHRDHDHDLGSPSLVDFDFNFLDNVFYPAFFASTSWSGAAPVAAEVLYNASDTTEYVAVNLDAYGVSSHLERLAGVPRAIMDSAHARKSSQAMNSNALANLEHIFTAKNLVRHVNDYFRYWHRNSRVVHRPSFTLGHVSDPLLVGVVLLGAMYSSSQNERRMAGSVMQYAEEYIFEQVPIVPRNECIRHNQQDENTLQSIQACLCMIVIQFWTGNAQSQHRTMTLRFGQVIEASYHIDLLRTTHTLEDRVSERAWLDVETRIRAATYLTLLDCAFLFFRGIPLRILSPEIECDFPCDEAVFDAEHPFTLPQFCFERTIGPKQAFKWLFKANTEPGEKPPDLTMLDTFILIHMLYRFTNDTLTLCTWGPRSSKNILARSTDIRLALDTWHKCWKLGRDRAQEQGVWDNFGFWKNGDQYETATRLLLSQATEPNIARLLASHVDRLNLLKQLTIPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M3D1D1</accession>
    <name>M3D1D1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_150259</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759419.1">
        <property type="nucleotide sequence ID" value="XM_016906055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D1D1"/>
    <dbReference type="STRING" id="692275.M3D1D1"/>
    <dbReference type="GeneID" id="27903192"/>
    <dbReference type="eggNOG" id="KOG1963">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005417_0_1_1"/>
    <dbReference type="OMA" id="TRIDGPH"/>
    <dbReference type="OrthoDB" id="4096at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000234">
        <property type="term" value="P:positive regulation of rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053826">
        <property type="entry name" value="WDR75"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23869">
        <property type="entry name" value="Beta-prop_WDR75_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="459"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="987"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="100"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1013"/>
            <end position="1025"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF11298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1098" mass="120506" checksum="C4B8558A1C41CB2B" modified="2013-05-01" version="1">MAKETERKRKLEQEHVNTATPKRQKQAQKSAAKANGTVNGSTPKHNAVPATTDTPDTPKLSKQEKKAARVSEVKTELQQPVNPDESQATPAKNAKKRKSLQNGASTHVKQVTGSNEPEKGADVPMVDADAGQAESKKNKKKKKQRVAQELVECEQVDTAAGAEQRSESGTILSTNDKRQRALEKKARRIAHREVKAGLKGDEELTKPNEYGWWLSQPSAGRYIAQDPIFVVDENGDECLIAATVREVQLLHLNSSLLARTHAVPDGRSILAYTLSAEYPDHVEVSYDNGAKVQWNWTNGSISNGNYPGQETTIAMTSASLADGRSEVYYISRSQGTYTIVGKRKALYSTYRRLQSIQVLGDGVYIICLGATAMVLGKKKDNSNTPEYIWIEMPTPMPFQCLDARLVLPASAKNTTEQKVGASDLALAIGNVEGQIHFYSSLNSLFGKASQATLPDPRILHWHREAVSTVKFSRDGNYLISGGRESVLVIWQLETGQKQFLPHLTAEVERLVVSPNGTQYALQLGDNSVMVLSTAELKPIANFAGLQLPVRSEQLWLEEMTVPATTAVLHPTNPSQLLLTVPATQPKYARDVTTRPFLQTFDLQNARHISRQALSRNNVTDFNRGPENTPIIPPDVNLLALSADGKWLATVDEWFPPATDLEHAVARTAGLDNIDLTNIHEQQLKRREVYLKFWKWDEQQQIWTLSTRADAPHARTSNSDLGNGAGRVLELKSDPASNGFATVGEDGEVKIWKSKPKFRNGVPLQDARGDDLMEWTCRRTVGLPIATDLEERADSPMDGVFEHNKTQSAIDACLAYSPDGSMLACTTISADETTQPLVHFINPNTGAVTATKTGIIPADEDVQSFGFLDRYFIVLSLGHIRVWNLVDDNVHYTIKLRGSVDEQENAKLAINSTDDTFAVASTLPMSIENDVIVPQIIVYTPKLPEPLFEAELESSPVALLAGQDTKGYTILFEDGTIRTLSSTAQVSSRDRRLSIATSPSDKMEEESQNMAENAETASSSALAKLSTKAEDQAMAESLAPLMLTEGEDDRPVIRPEHLTSIFDVGGSGGSVALPPVRDMFRDLVGLLAKKPRARVAMDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M3D222</accession>
    <name>M3D222_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cloroperoxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_150450</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759669.1">
        <property type="nucleotide sequence ID" value="XM_016906182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D222"/>
    <dbReference type="STRING" id="692275.M3D222"/>
    <dbReference type="GeneID" id="27903319"/>
    <dbReference type="eggNOG" id="ENOG502SJRK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050230_0_0_1"/>
    <dbReference type="OMA" id="YFFQNER"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF7">
        <property type="entry name" value="HEME HALOPEROXIDASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 10" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032245" evidence="8">
        <location>
            <begin position="24"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="9">
        <location>
            <begin position="33"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF11548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="262" mass="29636" checksum="243C3FA76CB173CC" modified="2013-05-01" version="1">MYTKTFFMHVTFPALALVGSTLALPQATNAVDPYANWQAPGPDDFRGPCPMLNTLANHGFLPRDGGAKNGLTMDDMVKAMTEGLNFDPLIARGAWTAGLVVNPNNTADRWDLQQLRAHNTLEHDASLSRADDYWNGNGWAFDQATFDETKSYWPDPLLNKTTLARVKIARQAKSKFTNPEYFFNMKAETFSLGEVLSLVAWGGDKETFTVRKDFIEYWFENERFPTHLGWTRPAEMFTAQDQNDLEHIIAVESSLRTDFEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M3D2F4</accession>
    <name>M3D2F4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase M3A/M3B catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_118620</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase M3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759443.1">
        <property type="nucleotide sequence ID" value="XM_016901441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D2F4"/>
    <dbReference type="GeneID" id="27898578"/>
    <dbReference type="HOGENOM" id="CLU_1190529_0_0_1"/>
    <dbReference type="OrthoDB" id="534666at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.40">
        <property type="entry name" value="Endopeptidase. Chain P, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024080">
        <property type="entry name" value="Neurolysin/TOP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF84">
        <property type="entry name" value="SACCHAROLYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="8">
        <location>
            <begin position="141"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF11322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="233" mass="26333" checksum="8F34191EFD7A902A" modified="2013-05-01" version="1">MAHQRSPPQACLKLIAQDKIFPLTRGNIDKLREVREKVVRNVSLQAATYESVVTPLADAQHAIEDSYGVIGMLKYAAPDDRTRQASKEANHLWDQAWSEFNNDHDVYLLLQAVKDRNMHLEAEHAKYLDELLANFLRCGFRFDMTVHDLPTPESCHALDPTQLYADFETRLEFLSVSDPKELGYPYASTFHLLAGYDAGYYGYLSAQVFGADLFGIFGEDAGNGGDDFFVRCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M3D2K2</accession>
    <name>M3D2K2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cyclin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_164883</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759493.1">
        <property type="nucleotide sequence ID" value="XM_016908137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D2K2"/>
    <dbReference type="STRING" id="692275.M3D2K2"/>
    <dbReference type="GeneID" id="27905274"/>
    <dbReference type="eggNOG" id="KOG0835">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022000_5_0_1"/>
    <dbReference type="OMA" id="WEDVWSV"/>
    <dbReference type="OrthoDB" id="10264655at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF11372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="301" mass="32881" checksum="DDA27930A5423BBC" modified="2013-05-01" version="1">MAPEPSVSGLSHLLNPLASSLQLETSASQLDGVPRHLEDSIRFETSRLVQAAGILLRLPQEIIAQCIVILQRFWTGPDGGSLLENDSKNVAAAALYLTAKPSAHPVSARQILTVFEYVSSLQPGQLASTESESKLGASWHLPEGHYEARKHALYDIEARILRVLGYQTHVALPHTLCINYLQTLDAFQSGAGKTVVKAAFAHLNSALLSPQMLYLTHQPSALATAAIYLAARETNTKLPETDWWEVFDVDREELGFLVVALQSIKAYALAERSGWGSRRVPLSVDDLRADLERAQLLAAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2024-01-24" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M3D475</accession>
    <name>M3D475_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_117533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761116.1">
        <property type="nucleotide sequence ID" value="XM_016901347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D475"/>
    <dbReference type="STRING" id="692275.M3D475"/>
    <dbReference type="GeneID" id="27898484"/>
    <dbReference type="HOGENOM" id="CLU_1603777_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013017245" evidence="1">
        <location>
            <begin position="16"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF12995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="166" mass="18166" checksum="9AD536AFF6B5440A" modified="2013-05-01" version="1">MKSLIFLASSALTFAAPQKAPSFSGAALVPTGSRNLAYEQRSDELCVSLSNGYLGDARKGIYQENLCFPADNSIKCNIPRLPNQLRSNVSSIRVPVNEVCSLYIEDNCGGKVTQYSHASDGTNLQGTWFDKKYRSVHCKKLDRPPPAVKFYTPTPDVPISESDATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>M3D4X3</accession>
    <name>M3D4X3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_148614</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761376.1">
        <property type="nucleotide sequence ID" value="XM_016905031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D4X3"/>
    <dbReference type="STRING" id="692275.M3D4X3"/>
    <dbReference type="GeneID" id="27902168"/>
    <dbReference type="eggNOG" id="ENOG502SM24">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013296_1_1_1"/>
    <dbReference type="OMA" id="IWIDELW"/>
    <dbReference type="OrthoDB" id="4898680at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF40">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="42"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="74"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="159"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF13255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="803" mass="89859" checksum="085A656AC9FC8134" modified="2013-05-01" version="1">MSSTHAGTMDIDETAPTDQQPSSKDRVVSVTPSYRRNGKLFSCEPCRRAKLKCDHNSPICGRCARRGKQNECMYHPAPLTKPRTGLGPQRTMSIPRAHDSTQSSYSATGADSSRPSDSLSPPSSTRTLSARKQTVSGSTDSRSLGYRSAEASPAGHMPYTSTEGSQPPSTASVQVPESDMSFRDISQGYLGATSYSAVYAEHQSILQTPHVEETPENLLPVTSVEKIQQGAQVLSILKDFPVYRQFMQRWFELSDGIMVIQPVFKIWIDELWTEYGHILAHGQPEELIALSELVWCNTRQPLKVHGDMTAKEWAKSASGKHLRWEVVGSILSMVGLIAVNLSSYDSIFDSIRECYVDRATFAERMRRASEFCLCFCYESEVLNEIYVSFIYEDLILVECLKGEAHYAAWQRTGELIDAVVAMGLHQGNKVSPQTPFFLAELRKKIFISAYGHDKVMATFLGRPPRLSQRYCKMEPPLDLSDDELFSEGAELRQALACLDENGWNTDEQLRRITWYRARFQVCRIREDILEIALGSSEDEDEDEVAYKAERVKRRMKHLKSSLPEFMNTTPEEALGEDNTRLGARFTIGPTKESSKMHINALWVVAVHAGIAHTEFLLERAKVNRLRTDTSKLIPVARRMLKLVLLVQSKKDVFRDFQGDLTYMLAFDGLYAAGVLAVELLTQARTGQHTNDVLPRSETIQDLSVFISALGAVRPGEGNYSICSQGRRTLTRALDQILSPHPLPPPETAQGEAVTYDDTSLAFPIGSDVEFLQWLEHVEWDKSIWIDPLTTAQGEASASDVTAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>M3D511</accession>
    <name>M3D511_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_148635</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761406.1">
        <property type="nucleotide sequence ID" value="XM_016905045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D511"/>
    <dbReference type="STRING" id="692275.M3D511"/>
    <dbReference type="GeneID" id="27902182"/>
    <dbReference type="eggNOG" id="KOG0964">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001042_5_0_1"/>
    <dbReference type="OMA" id="GQKTVCA"/>
    <dbReference type="OrthoDB" id="431497at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03272">
        <property type="entry name" value="ABC_SMC3_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000370">
        <property type="entry name" value="Structural maintenance of chromosomes 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000424">
        <property type="entry name" value="Structural maintenance of chromosomes 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041741">
        <property type="entry name" value="SMC3_ABC_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43977">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="11">
        <location>
            <begin position="522"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="707"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1053"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="193"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="260"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="413"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="866"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="977"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="725"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF13285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1204" mass="137579" checksum="EAB3C98238E51D5E" modified="2013-05-01" version="1">MFIKQIIIQGFKSYKDQTVIEPFSPKHNVIVGRNGSGKSNFFAAIRFVLSDKYTQLSREDRQGLLHEGTGSAVMSAYVELIFDNSDDRFPTGTPEVVLRRTIGQKKDEYSLNRKNTTKQEVLSLLESAGFSRSNPYYIVPQGRVTAITNMKDQERLNMLKEVAGTGVYEARRAESFRIMEETKAKRTKIDDLLEHIRGRLGELEEEKEELRQFQEKDKERRSLEYTIHHKEQQRLEEQISRLDEDHGEGMDHNEQNREALKANEQQLDAIDGQIASLQQQISLLLQEQTQYKEERTESARSKAQIEADVQAMQDNQASAQQAQNALNNELLNVQKQIKQHETRLAQLLPNYQAKKDANKAAQDQIHEATATIQRLYAKQGRQAQFRTKKERDGWLKQEIATTNESLAARKAISMQAQDEIAEFETQIAQLEADIAELRHRVENRGDAQQNISAEVQQAKDEAERLHDQRRELWREEAKLGTVISNARAEYDKAESILAGTMDPNTARGLVSVRRIVQQHGIEGAYGPLGELFETSPKFKTAVEVTAGASLFHYVVDTDETAEKLIKILQQERGGRVTFTPLNRIKVRETELPNSSDAVPIIGKIKYDMKFDKAMQQVFGKTVVCVTLQIAAQYARSHGVSAITAQGDRSDQKGALTGGYFNPRNSRIDALRRLMAARDEWERVRGRGDEIHDELQKLDQQVTKAKSNLQKIEQKRDQLEGGYGPLREELRRKEQDLGKRRDDIDRQQRARENIDTLIKDLSNQMSGYQSELQADFKKALSNQEERELETLSAQLPDLRKQYSELGRELSELENQKRNLEDILNVNLRPRLDELQGADLDANVNSSGNSNSRLKDRSNDLKRITKALNTIDKKLLELETSIESAQEQLHNLEANRVEQRAEVEKFEQAIRRYQNRIEKGAERRGAFQALLNQELATIRSLGVLPEQTFRPEYTELSSDRATKRLHKAQEALKKYGHVNKKAYEQFQQFEQKRDELEKRRQDLDLSDKSIKELIDVLDQRKDEAIERTFKQVSREFHIIFEKLVPAGTGFLKIGRNSDRQVNGGAEEESEDEGARSRKVENYTGIGIHVSFNSKHDEQQRIQQLSGGQKSLCALALVFAIQASDPAPFYLFDEIDANLDAQYRTAVAQLLQESSQSGQFICTTFRPEMLHVAEKCYGVSYLNKASSIDVVSKEQALDFVEGQISGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M3D5P6</accession>
    <name>M3D5P6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_125240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761591.1">
        <property type="nucleotide sequence ID" value="XM_016901964.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.M3D5P6"/>
    <dbReference type="GeneID" id="27899101"/>
    <dbReference type="eggNOG" id="ENOG502SI51">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002643_0_0_1"/>
    <dbReference type="OMA" id="DETMTPR"/>
    <dbReference type="OrthoDB" id="5423926at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="681"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="725"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="888"/>
            <end position="1496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="564"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="791"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="821"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="850"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="932"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="951"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1032"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1060"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1086"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1108"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1131"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1155"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1198"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1225"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1292"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1400"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1422"/>
            <end position="1447"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF13470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1551" mass="163586" checksum="71C419DBF0031E3A" modified="2013-05-01" version="1" fragment="single">MALFGSRRRGSSAARQPLDANTAYAAGVAARAAAAASRPGTSSGLSSAAAAAALRSVTSSPEPVGSIQTRRMVRRGSNSSIGSASIMSGNGRGASMRGGSMQRRGSQGSMAERTFRSPSPGRARGGGGSGGGDRQRRGSQSSMTERTFRSPSPGRSRTNSFTNNGSPVVDAPPVPTIPKSMQQGSAHQRSLSMEPPQRVYSPGPYGRGGRTNSMDRSTAPPPVSTRKGMQLADVNESELERSDSQRKKNISQPQTSQPTSPTSPSRGKAYTHGTGGWYAEPVQNKPTSNGGPGPNPDQLAAKMARIQSAQGQSVKKDGQNSSSQGAQLKTYTQPTITGTAVRPQARPQQATETVMVYDSNSRTFVPQIKTKSAVVEPPSPTLPPLPAAAPGTYDPHTRTIVPVAPAPDVAPPPRNPARLSPTTSPRNSYLQHQPSTVHEDPEEKEEEEEEEEEEGAASLDTPTSARMIQTSVGPAKSYVSAVQQQHQRSASLDVPSRNTPSIRGRQVSASPSPQRKTHFSASPVSHATRHDPPPRDISPAKSALKNSNSPAPSARTASPLAHFSGQSMGPGSDVSSVYSQDGISSMVKKKKKSARVSFDEQPHEIEVPAAAPPKVSRARSPDLDDSDDEDFSKPRPVLPTFGSIRKNREVAEKVTEMAPDRLEYSNDHAIGSILHGANGATKLAGEPMPPVVTSKDTPVNISDSDSISDVGDLGEYVAANAAHVNLPEQTAEQAAPIHEEPSAQSPIEPSERSPVEPIVRDFASVGTAAQKAHDPSVPHISLLPPTPGTEEFTSLDNRQSAEIVVPGGWGAETETDAKSAIATTGTPQHDGASTGTLNSTEEHPPILTPIDEDTDTDDAEFSDAAEDPSEFEGGFASLDAIAVSPITVKPSSGELPASPIKSLTSPPDSPTAPKALGQSDGSTGTTEDKSSGDWTSATAYWSQLSRQQRAQIERDHMSSDDEARPSPAATKKTRKTPPQPISTQASPRSVPAHRIAQPAQPALKNAMRTNPAPVESNHSMRKSMRDGGGLSSGSLRSRSSSAQPAASEQRAGALVKKTMRPQSSGPTVAYSMSNGRVSQEHSYTKPVLTRPVSSTSTTPAPPVVSQRLQKELLNHDSDSESSFRKKKRSNSMTSGGMSMKRSMRGGLPDQGAPAREQRRLSPDRVGRGKGKDSFSIRSLSPTGSIFGRKKAKDVRNSIRGSSVASSGRMTTMRTAQPAKTMRQTPAPAAQKASASSSRFKSRFADSDDSDDDAPPARRGGGGGFRSRFADSDEEDADVLTPVRGIPRRSGQDDGDSTDLDDSDAEGGHKSSSRARNGQIVPLVPDPADVEKAMAVARKNLGITSDPPSTPQKKDDSRDSALAPGSPRASQPPPPALPQSPDINSARKKSFMGGLLRRNRNSQQSVMTVSGMPQNGGAPLIQQHETPTRPQGSQRDSSYSARPQSPTASPGKLIRRASGQPHQRMVRGDSTYSTATAPPMMGESSIWPSGDVPPVPAIPADLQTLKGDGRPATSDGQGVRFSEDVTVSPGAYSARTGRKKKFGMLRRAFGLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M3D8S4</accession>
    <name>M3D8S4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">rRNA methyltransferase 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_62530</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762415.1">
        <property type="nucleotide sequence ID" value="XM_016909606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D8S4"/>
    <dbReference type="STRING" id="692275.M3D8S4"/>
    <dbReference type="GeneID" id="27906743"/>
    <dbReference type="eggNOG" id="KOG0838">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021322_5_3_1"/>
    <dbReference type="OMA" id="HNGCILE"/>
    <dbReference type="OrthoDB" id="270651at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18105">
        <property type="entry name" value="SpoU-like_MRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047182">
        <property type="entry name" value="MRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047261">
        <property type="entry name" value="MRM1_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46103">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46103:SF1">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="RNA 2-O ribose methyltransferase substrate binding" evidence="11">
        <location>
            <begin position="87"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="20"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF14294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="412" mass="44517" checksum="90D4D230735405D4" modified="2013-05-01" version="1">MPDGKRSVIYVTRDGAIDLAVGTPAPGTVRPRNPDSTGSAQSMEPSKYERRATRNDDRPSRRRRVEEDEEEDEIPVSIPYTTAASEFIYGYNSVIAALKARRRKLYKLYIHRKIFEEVVGAQGTTSGEKPVNELMALAKEAGIPFHNESKTAMLDKMSDGRPHNGVILEASKLPTVPVLGLRKPEITKGYIPLELAPQSAEDAKINGSPQVINSLTGSWRYPFVVLLDGITDPGNVGNIIRTCHVYGVDAVAVATNTCANLSSAVLAKASSGACEAMRLLSLPQPSNFVHDSSKYRWKVYAAVAPTGKPDSAGQFLNTSKLAADSPLAKHPCILMLGAEGEGLRQNLRNRADHFVSIEGGPKAESVPDVGVDSMNVSVATGVLLEAFLRKPVDAPDSIAQDEQVEEGKEEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>M3D928</accession>
    <name>M3D928_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_115916</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762771.1">
        <property type="nucleotide sequence ID" value="XM_016901205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D928"/>
    <dbReference type="GeneID" id="27898342"/>
    <dbReference type="HOGENOM" id="CLU_1866379_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF14650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="137" mass="15256" checksum="02F3D0EF19A1F061" modified="2013-05-01" version="1">MNIPILQQHTPSPVLPIDATFNSVMGHVGNWCFLPFSQLDFKLSNSKFPDIGLVSFTVVMRDGGISDSVPRGIFLNIGNTVLRGRRLVLRELRRDSKSPERVFTMQEAFSAIVHDMPSTRVRLVSAELAFTSDADAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M3DBQ8</accession>
    <name>M3DBQ8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribonucleases P/MRP subunit Pop8-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_26642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763611.1">
        <property type="nucleotide sequence ID" value="XM_016908415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DBQ8"/>
    <dbReference type="STRING" id="692275.M3DBQ8"/>
    <dbReference type="GeneID" id="27905552"/>
    <dbReference type="eggNOG" id="ENOG502SCWV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115053_1_1_1"/>
    <dbReference type="OMA" id="QVKSYCT"/>
    <dbReference type="OrthoDB" id="422362at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000171">
        <property type="term" value="F:ribonuclease MRP activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034965">
        <property type="term" value="P:intronic box C/D snoRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000294">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, RNase MRP-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020347">
        <property type="entry name" value="Pop8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049128">
        <property type="entry name" value="Pop8-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28173">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28173:SF1">
        <property type="entry name" value="RIBONUCLEASES P_MRP PROTEIN SUBUNIT POP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20976">
        <property type="entry name" value="Pop8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribonucleases P/MRP subunit Pop8-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF15490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="120" mass="13133" checksum="EF23F507B262476F" modified="2013-05-01" version="1" fragment="single">SIRNPHWSYIHLEHMHSTSTSSSISNINQQEGKEELDPVTAQLHLSAALSALHGLHGLAIPIDLLHITGQQVWLRTPADDRSAVLAAVGGWMSNSGDRWRIKGWSHWSASALGRDAGQDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M3DEU4</accession>
    <name>M3DEU4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Alcohol oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_154708</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF16039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764160.1">
        <property type="nucleotide sequence ID" value="XM_016907580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DEU4"/>
    <dbReference type="STRING" id="692275.M3DEU4"/>
    <dbReference type="GeneID" id="27904717"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002865_6_0_1"/>
    <dbReference type="OMA" id="MSAWHAV"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.450.10">
        <property type="entry name" value="Glucose Oxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027424">
        <property type="entry name" value="Glucose_Oxidase_domain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF201">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0274">FAD</keyword>
    <keyword evidence="3 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032419" evidence="9">
        <location>
            <begin position="17"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="10">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="11">
        <location>
            <begin position="298"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="528"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="571"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="37"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF16039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="591" mass="63198" checksum="4270BDBAB0C91631" modified="2013-05-01" version="1">MSRSIAGLALVAAALAAPAALPRAASEYDFIVIGGGTSGLVVANRLSEDPNVSVAVIEAGGSVYDNPNVTSTTGYGLAFDTPIDFAYQSEPQPYAGNKTQVMRAAKALGGTSTINGMTYMRAETGQIDAWAKLGNNITWDSLLPYYKKAESFEKPSSAQVEDGASYKADAHGFTGPLAVGWPATMVGDNFAGILNSTFDALGLPWNGEPNAGYMHGYNIFPKTLNTSADIREDAARAYYFPYESRSNLHVYFNSHANRLTWANASSDSKPFANGVEYTDASGASQTLCAKKEVVISAGSLRSSVILEYSGIGNPTILNKYDIDVKVDLPAVGENLQDQTTTDTAYTASKNFTGSGGHIGYFNARDAYGDDLDKVSAEVKASFPAYAKTVVDYTGGVVNQSALETLFNIQHKMIFEDLDVICEVIVNAPSSGAASLQYWGLLPFSRGNIHINSADPAAASSIQPNYFQLDWDLKQQIATARAARSVTTTAPFSDMITGETTPGLDLVPADASDEVWGEWLKSTYRSNFHYISTAAMMPQEMGGVVDSDHVVYGTANVRVVDASVLPFQVSGHLTSTLYALAERAADRIKETY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDA0</accession>
    <name>N1QDA0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_151364</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757396.1">
        <property type="nucleotide sequence ID" value="XM_016906765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QDA0"/>
    <dbReference type="GeneID" id="27903902"/>
    <dbReference type="HOGENOM" id="CLU_2185590_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF09275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="109" mass="12213" checksum="41316FA429841744" modified="2013-06-26" version="1">MHEFSMNEHNKPTRDVPKALVLCRIGVIVGPTFASTSAIVAAHFVRALHFGIVKHNSFISTIDSRILQWLVRQYINIQDVFGEPQTSSQRTSPSTTLQTSRKHPSTLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDK8</accession>
    <name>N1QDK8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Ribosome biogenesis protein NOP53</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_151518</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May play a role in ribosome biogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the NOP53 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757662.1">
        <property type="nucleotide sequence ID" value="XM_016906868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QDK8"/>
    <dbReference type="STRING" id="692275.N1QDK8"/>
    <dbReference type="GeneID" id="27904005"/>
    <dbReference type="eggNOG" id="KOG2823">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035888_1_0_1"/>
    <dbReference type="OMA" id="TEKWTHK"/>
    <dbReference type="OrthoDB" id="5072at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011687">
        <property type="entry name" value="Nop53/GLTSCR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14211">
        <property type="entry name" value="GLIOMA SUPPRESSOR CANDIDATE REGION GENE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14211:SF7">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NOP53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07767">
        <property type="entry name" value="Nop53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017302">
        <property type="entry name" value="Gltscr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="281"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="222"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="103"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="293"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF09541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="440" mass="49356" checksum="BC161E06DD1F6A0C" modified="2013-06-26" version="1">MADDNKTAVAPATYSQPSRKGKKAWRKNVDITEVSAGLDNLRAEIIQGGPIKEKTSDELFATDITGDPEIERKQKSRKVLKVDEILAARSSKVDPLQPARKRKAEDHSGSGVDGKRVKANGKYISHRELARLRKVADGGQIGIIVDDQASNDLWGVPEPQPEEQYTFLEKKRDKVAPASLKQAPTPLTASGKAVAAVLKPAGGKSYNPLVGDWSALLEKEGAAAVEAEKARLAAEQAQLEYDRKAEEIAAQVEANEKDEHATDYESAWESEWDGIQSEGEAEIHVQKQKPRKTPTERNKVKARKEREAKEKWEKKQKIRDAQERRIKQIAREVAAKERARQGIVAVVDDSSASDEDEDGLEVRKRRFGKVQVPDAPLEVQLADELQDSLRRLKPEGSLLTDSYRNKIINGKLEPRKKVGQVKQKQTMRREKWTYKDWQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDW7</accession>
    <name>N1QDW7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_150524</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758522.1">
        <property type="nucleotide sequence ID" value="XM_016906236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QDW7"/>
    <dbReference type="STRING" id="692275.N1QDW7"/>
    <dbReference type="GeneID" id="27903373"/>
    <dbReference type="eggNOG" id="KOG2497">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038942_1_2_1"/>
    <dbReference type="OMA" id="PIRTYRI"/>
    <dbReference type="OrthoDB" id="194386at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF130">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EEF2KMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF10401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="343" mass="39157" checksum="45E48DA97A514B78" modified="2013-06-26" version="1">MDAQLLLFRRQYLQLFEPDFLAWPPKQLLRDSAVQAWLYKHLFDCEKNRYLPPPRYQLRVLKPLLAKIEKSIEDPEEDEISDDLMNHLGALISADLPEEATAVQQKTYVTFTCLPPTATITEDYRDEPTITLLERPQLLSGSLTTGFRTWEAALHLGSYLLLPENRDLIRGKNVLELGAGTGFLAILAAKHLEANHVTTTDGDEGVVEALKENLFLNNLDDEKKVLTSVLRWGWGLIGTWVEEDCDAYPYDVILGTDITYDKAAISALVATLRLLFDMRPKLHVLISGVVRNLDTFETFRHACLRNKFEVVEIDFHPKSIEQQTSLFYQKAFPIKILSIRKPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1QE78</accession>
    <name>N1QE78_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_119188</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758777.1">
        <property type="nucleotide sequence ID" value="XM_016901485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QE78"/>
    <dbReference type="STRING" id="692275.N1QE78"/>
    <dbReference type="GeneID" id="27898622"/>
    <dbReference type="eggNOG" id="ENOG502SQDU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_502642_0_0_1"/>
    <dbReference type="OMA" id="WCCNADA"/>
    <dbReference type="OrthoDB" id="5215637at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110701" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="26"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="334"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="394"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="474"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF10656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="542" mass="56768" checksum="84EA15C432691218" modified="2013-06-26" version="1">MKSQKMLRAAGCFAVLHFALESVSAQNCYYPNGDVSRTDASCSDDGGACCPLDWICLSNGLCWLDDSNDYYGRYTCTDRSWGDDCPQYCTSNNTAAGNEAIVQCADGSWCCDKNRDPTKVDCCDWDDKETIDVGNPIPVTRIESTPTAPSSDAPPTTTNKAATSASASASTTSSSHSSSSSSSITPTSSTSESTITTTATSSDSAGGIVIITSILTTQIPISTGNADPSTAAHHAPSNNGIVIGLSVAIPVALLALLLTIFILWRRRKQKQYAQRQPPTSDYARHDMISDMYSHSKTANEIDSYPVADVSGGGGGKDQSRPISELTGSSHFFMTPNSPVSTTTKNSSSSNGIVSPPGYSPSVVYGGPGDGGGTTRGGGGGGGCWTTSPLLPGVAEQPEPQELPAEGNSSSAARRSGLAQPSPLPALPQHHHQQGSQPMMPEVNHDMVGGSNNTTFQSGPYSQFYQPYRLPTEAPPEVANAAEAVGTASAHQQQIRADHTSSAMGQKEEDGSSSSRMFDEERGRFSPDPPQPATQGGLRVVNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1QE97</accession>
    <name>N1QE97_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_51482</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757363.1">
        <property type="nucleotide sequence ID" value="XM_016909192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QE97"/>
    <dbReference type="STRING" id="692275.N1QE97"/>
    <dbReference type="GeneID" id="27906329"/>
    <dbReference type="eggNOG" id="ENOG502SU7Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1524866_0_0_1"/>
    <dbReference type="OMA" id="ICRITPV"/>
    <dbReference type="OrthoDB" id="3650882at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="31"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF09242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="212" mass="23351" checksum="42315BE023EBD978" modified="2013-06-26" version="1">MAVFNIPSASAHVIIVAIVACIWTLFTCLCRIFLRTKVNGPIGPDDVACLVATFLGISQSTLTLVAVHFGVGNHQDHLSRLNLKKNTIVLWVAEQFYILTTAATMISISCLICRITPVRRHHLIGWTIGIMTIIWAIVFWFLRIFICSYNLQANRSVGKASTEAKAMHVGHLPQPWDPSNNICLNRTAIRLAVTIVGSFLELANVVTAVCVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1QEC7</accession>
    <name>N1QEC7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MT-A70-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_166039</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MT-A70-like family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757423.1">
        <property type="nucleotide sequence ID" value="XM_016908198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QEC7"/>
    <dbReference type="STRING" id="692275.N1QEC7"/>
    <dbReference type="GeneID" id="27905335"/>
    <dbReference type="eggNOG" id="KOG2356">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027091_4_1_1"/>
    <dbReference type="OMA" id="PLEYNVE"/>
    <dbReference type="OrthoDB" id="61116at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007757">
        <property type="entry name" value="MT-A70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829:SF4">
        <property type="entry name" value="N(6)-ADENINE-SPECIFIC METHYLTRANSFERASE METTL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05063">
        <property type="entry name" value="MT-A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51143">
        <property type="entry name" value="MT_A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF09302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="467" mass="51828" checksum="0C485027DF5C007D" modified="2013-06-26" version="1">MYGAGCVVEVGVQGDRVGDIEIRVLVFECGIALHNMLSWESGGSLPTCRSAESVLWQSEDKTTVLIDIPGSVAVAQGTADEPCAHVLQSSVPLQKPFSIPAPKLVKAEGNLSNKSEDENYRVLLKAALGTVESRCNGQWCLPRPFIFEGDQDREEQGEPSSRKRKSTDIDQSLSRDPLPPTLLEVAVKGTRIPLEYNVEPRSNRLEQDYEFDYEPGSNLWTYTTVPAILTITSHVLDTATSLQYRFRLPANSVAYLSDCSQPRSFHELVNERQQKFDFILLDPPWPSRSVKRTHQTPGTSYSTTKLIDLDTMLCGLNLRSLLTGPGYVAIWITNKPAVRALVLGSGGLFEKWGISLAEEWIWLKTTAAGEPSSPLGDTWNGKKPYEILLVGKSGQSGVTNLKRRVIVGVPDLHSRKPCLKELVGDLIGTEAPVLEIFARHLVSGWWSWGNECLKFNWEGYWQQADEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1QEX2</accession>
    <name>N1QEX2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YOP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_149591</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759793.1">
        <property type="nucleotide sequence ID" value="XM_016905648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QEX2"/>
    <dbReference type="STRING" id="692275.N1QEX2"/>
    <dbReference type="GeneID" id="27902785"/>
    <dbReference type="eggNOG" id="KOG1725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028431_2_1_1"/>
    <dbReference type="OMA" id="DTQYWVV"/>
    <dbReference type="OrthoDB" id="10009287at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300">
        <property type="entry name" value="HVA22-LIKE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300:SF161">
        <property type="entry name" value="RECEPTOR EXPRESSION-ENHANCING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF11672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="170" mass="19110" checksum="A06045ABFB264208" modified="2013-06-26" version="1">MSQAGSVQERAQYHLSALDKELSKYPVLNNFEQQTSVPKVYVALGLGALYFFLVFFNIAGEFLVNTAGFAIPAYYSLGALFTSGKADDSQWLTYWVVYAFLTVIESAINAVYWFPFYYTFKFILVLWMALPQTGGAQVVFRSLLQPLFARYFNDDPSATLKAKVNAAKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-12-14" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>N1QF34</accession>
    <name>N1QF34_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_149686</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759939.1">
        <property type="nucleotide sequence ID" value="XM_016905707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QF34"/>
    <dbReference type="GeneID" id="27902844"/>
    <dbReference type="HOGENOM" id="CLU_1661888_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF11818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="159" mass="17398" checksum="172959426F85056E" modified="2013-06-26" version="1">MPRSNASRTTRFESVRTGCNPDRDARLLKPCSWNCLDIIFDVPGTPGEGWDQDRFRRVLPIVLRCERWVMSHVLHATACKYADMSTASFSPCLRSPLGPFITTTPSSTGPRIGREAQPLISGVLLPAREGMPESDSASYLQTHACPDFDGGGGSIVTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFB5</accession>
    <name>N1QFB5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_149790</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760099.1">
        <property type="nucleotide sequence ID" value="XM_016905770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QFB5"/>
    <dbReference type="STRING" id="692275.N1QFB5"/>
    <dbReference type="GeneID" id="27902907"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_19_3_1"/>
    <dbReference type="OMA" id="DWTHPSG"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000115">
        <property type="entry name" value="Salicylate hydroxylase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF242">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="24"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF11978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="474" mass="51932" checksum="37A3154FF5BFD2ED" modified="2013-06-26" version="1">MASLEMFPDIEVLSQRHLPENNRTNIVVVGAGLGGLGAAIALLLAGHNVHVLESASQIGEVGAGIQALPNSSRVLIQWGLGPTLAKLATVPVQVEMLGWKGNAITQYDFGAATKEYGAPFWDFHRADLHGAMLDRARELGCTFQTKARVVDVDTSQMTSATVLLSSGEKIVADLVIGADGIHSKCREIMLGGPSPPVATGDLAYRVLLGTEGMQNDPDLAPFLKTHHVRYWMGPGAHAVSYVLRNGQQINVVLLVPDDMPAGASTVDGNVEEMQALFQQWDPRIPKLLQYCQSVQKWRLCFRPGLERPWSNEAGTFALLGDSVHATLPYLASGAGMALEDGAVLGHCFSRVSDKRTHAKKQALAVYEQCRRTRTERIVERGNVQQYLYHVDDGAEQEARDARFRAFAQIEKLVEEDGMSTAEIQLPDGLEIGSDPLAWRRFGVGSWLINYDCLADVQRNWLHLQSTEPQFRSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFZ4</accession>
    <name>N1QFZ4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_126499</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760318.1">
        <property type="nucleotide sequence ID" value="XM_016902078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QFZ4"/>
    <dbReference type="GeneID" id="27899215"/>
    <dbReference type="HOGENOM" id="CLU_068097_0_0_1"/>
    <dbReference type="OMA" id="HHLYGFS"/>
    <dbReference type="OrthoDB" id="4337792at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051430">
        <property type="entry name" value="Fungal_TF_Env_Response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944:SF129">
        <property type="entry name" value="ASPYRIDONES CLUSTER REGULATOR APDR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="34"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF12197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="437" mass="47672" checksum="2DBECF22064FC82D" modified="2013-06-26" version="1">MSNCEGPNITLATLQTYCLILLAQQTTGLGLSTISISIDALVRAAMRLDLHRPQRPDCGSSLSETDVQLRKKLWCTIVELSIQSSLDAGLPPSLLPADLQIDLPSNIDDVEISHSAPKPLNSSNKTDATVQILLARTATVRLRILHHLYGFSSIESYDTILQLGGELMDQYRANVRMLEDLSSQPCAGHSDMSTRFQMSLLDALTLGPLMALHSPFAYLARANPKFYFSRKICFEAAWALPSRRLPPSTQRSAGPTRTLYDALLVHASGLFERVHLQSTALICMEMLSSFTEGSFLSNSLFDSAVVLEAVQQSIDLCARRLDNGTTDVASHVILSCALAHIRALKSRSEPQVLVAEGAVQSLKECLHTLQCAAARRRTATQSSMAVEATEPGISHDSNALNEDWWASQDPLDLTITSASWWGGEDGSLLNDSAYQST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>N1QG72</accession>
    <name>N1QG72_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_150797</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758933.1">
        <property type="nucleotide sequence ID" value="XM_016906403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QG72"/>
    <dbReference type="STRING" id="692275.N1QG72"/>
    <dbReference type="GeneID" id="27903540"/>
    <dbReference type="eggNOG" id="KOG2228">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_366075_0_0_1"/>
    <dbReference type="OMA" id="SETHADH"/>
    <dbReference type="OrthoDB" id="343623at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001597">
        <property type="entry name" value="Origin recognition complex subunit Orc4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016527">
        <property type="entry name" value="ORC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032705">
        <property type="entry name" value="ORC4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12087">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12087:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14629">
        <property type="entry name" value="ORC4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orc1-like AAA ATPase" evidence="7">
        <location>
            <begin position="347"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 4 C-terminal" evidence="8">
        <location>
            <begin position="539"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="152"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF10812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="762" mass="83694" checksum="DCA11000CBDA2211" modified="2013-06-26" version="1">MSGRPLKRQKVDDSAQKSSPARSAKPSNAPTTYGSKSQSSPAVHSTIQSNSDAKAEWLAAKAIAAKRAATRPRKSRELPPKEELSVYDDFEGAHQARRPAALSRGRTPKPPLNGSVERSADGDNPESHTKTRASRIVSQGNGRVTETGAPKKTFEDEIHEIEEKARQQTQNDDSADELAEQSGSKRGSARRASQRATAAKTVVAGTHTGPQDRRTGTSPRDQSLEIPESDEEDHMVIDRPDETLVQDDMDFNQLARQKEVTPKAAIAKRLIVPTKASITQPTRNAEAKIIRTTGSKPRRDADVKPMRKAIATDRNSFDDDHLQCIQNVVLEKATGKRPILLTNLDDEYAKVATVISQTITAGESNSMLIIGARGSGKTAMVNQILRKQSETHADHFHVVRLSGFIHTDDKIALREIWRQLGTEMELDEDEATSKNYADTMTRLLALLSHPTEHGIETERVTKSVIFVLDEFELFAGHPRQTLLYNLFDIAQSRKAPIAVLGLTTRIDVVESLEKRVKSRFSHRYVHLSLSKNLNAFEQTCRSAVALRPEEFTNKELEILAKGKELTAPALSSWSSVTDQLLASDTCKKFLQRLYYTTKSMPDFLVALTLALATLPTASQTITSVFDHISANMTSTSILQAPDSKLILLHALSTLQLALLICAARLTNIYDTELVTFALVYEEYKVIASKAKLHASASGGIASSRVWSKNVARNAWEELVNVGLVVEDGRSAGAKTSRVDVGLEELGGSGADLGGWGKWCREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGE0</accession>
    <name>N1QGE0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">S10_plectin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_55307</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764341.1">
        <property type="nucleotide sequence ID" value="XM_016909354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGE0"/>
    <dbReference type="STRING" id="692275.N1QGE0"/>
    <dbReference type="GeneID" id="27906491"/>
    <dbReference type="eggNOG" id="KOG3344">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089349_0_0_1"/>
    <dbReference type="OMA" id="YRRRDQE"/>
    <dbReference type="OrthoDB" id="5211809at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000025">
        <property type="entry name" value="40S ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005326">
        <property type="entry name" value="Plectin_eS10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037447">
        <property type="entry name" value="Ribosomal_eS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12146">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12146:SF0">
        <property type="entry name" value="RIBOSOMAL PROTEIN S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03501">
        <property type="entry name" value="S10_plectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Plectin/eS10 N-terminal" evidence="7">
        <location>
            <begin position="3"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="90"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="108"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF16220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="168" mass="19087" checksum="D214012682DC59E7" modified="2013-06-26" version="1">MLIPKEDRKKIHEYLFKEGVAVAKKDFNQPKHNEIDTKNLYVIKACQSLTSRGYLKTQFSWQWYYYTLTPEGLDYLREWLHLPAEIVPQTHVKQQRSHAPPRGMLGGDGDRERRGGGRGGPRREGGDREGGYRRREFGENKDGAAPGGFNPEFRGGFGRGRGAPPAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGI7</accession>
    <name>N1QGI7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dolichol phosphate-mannose biosynthesis regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_145572</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DPM2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764406.1">
        <property type="nucleotide sequence ID" value="XM_016903139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGI7"/>
    <dbReference type="STRING" id="692275.N1QGI7"/>
    <dbReference type="GeneID" id="27900276"/>
    <dbReference type="eggNOG" id="KOG3488">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150144_2_1_1"/>
    <dbReference type="OMA" id="YTLWIIV"/>
    <dbReference type="OrthoDB" id="311279at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033185">
        <property type="term" value="C:dolichol-phosphate-mannose synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180047">
        <property type="term" value="P:dolichol phosphate mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009914">
        <property type="entry name" value="DPM2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15039">
        <property type="entry name" value="DOLICHOL PHOSPHATE-MANNOSE BIOSYNTHESIS REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15039:SF11">
        <property type="entry name" value="DOLICHOL PHOSPHATE-MANNOSE BIOSYNTHESIS REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07297">
        <property type="entry name" value="DPM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF16285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="95" mass="10408" checksum="F4D6ADB23288EA50" modified="2013-06-26" version="1">MASNTLLDRLVGLAMLVLASTVFLYYTIWTLLMPFVDDSHPIQQLFPPRVWAIRIPVILLLVGGAVVGSFLSVVMIKSNKKKALKAKKAAAAKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGL7</accession>
    <name>N1QGL7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Krr1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_121902</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KRI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764482.1">
        <property type="nucleotide sequence ID" value="XM_016901738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGL7"/>
    <dbReference type="STRING" id="692275.N1QGL7"/>
    <dbReference type="GeneID" id="27898875"/>
    <dbReference type="eggNOG" id="KOG2409">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009647_3_0_1"/>
    <dbReference type="OMA" id="WDNYDPR"/>
    <dbReference type="OrthoDB" id="10252032at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018034">
        <property type="entry name" value="Kri1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024626">
        <property type="entry name" value="Kri1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14490:SF5">
        <property type="entry name" value="PROTEIN KRI1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14490">
        <property type="entry name" value="ZINC FINGER, ZZ TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05178">
        <property type="entry name" value="Kri1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12936">
        <property type="entry name" value="Kri1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kri1-like C-terminal" evidence="3">
        <location>
            <begin position="500"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="41"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="310"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="399"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="619"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="70"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="107"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="190"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="231"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="400"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="482"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="641"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF16361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="656" mass="74716" checksum="DCB595E68F370026" modified="2013-06-26" version="1">MPRAMKKQKLDLSDDESDAGVKIEPSTFKINESYAARFEHNKKREEQARLEEKYGAGNVAGNGSKRKFDDDDDEDDDSSTDEEEDDDAELADEEVDEEIENVLQAIRNKDPRIKDPNVKFFKDYNPEQDGAKGKEKEGKPMTLHDYQRERLLAGEMGDNDDEEVPVQTYQQEQDEMRKNLVGQMHATAADDAESEDNDDEEDGMLVRKKKSKHEDLPTADTKSKSRKKKVKITEQDINEADKDPETYLSNFMAARAWLPTDGSRFQPLESDDSEDEKKAEEYEHLYNLRHEDPTANEKLKSFSRDVGKYGVRRDEKTGRAKQREREKETKEAAKREREEEKARLRKLKVEEAEEKVKRIKEAAGLRGKAIDLDEWRDVIEGDFDDDKWEQEMKRRFGEDYYAEDDAMSEDEDEKAGGSKSRKPKKPKFDDDIDINDIIPDFDAGDKPNITLTDDEDDEEGGAPLPPASDEETSGKKRKTKKDRLQEKSDAKRAARKERAKIEEIIDSALPLSHPTLASSAGSHKAPVTGFRYRETSPTSFGLSARDILFADDTALNSYAGLKKMAAFRDQEKKQRDKKKYSKKQRLKMWRKETFGTPDEPTGGFERILGTFGEQVSTGANHVNLAAAEESGKSNGTSKEGTKKKKRSRKNKSSSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGR0</accession>
    <name>N1QGR0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_150490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758454.1">
        <property type="nucleotide sequence ID" value="XM_016906213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGR0"/>
    <dbReference type="STRING" id="692275.N1QGR0"/>
    <dbReference type="GeneID" id="27903350"/>
    <dbReference type="eggNOG" id="KOG1199">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_42_0_1"/>
    <dbReference type="OMA" id="RHIFEND"/>
    <dbReference type="OrthoDB" id="3819888at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658:SF8">
        <property type="entry name" value="17-BETA-HYDROXYSTEROID DEHYDROGENASE 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="3">
        <location>
            <begin position="6"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF10333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="277" mass="29508" checksum="31ED8F5A08560E07" modified="2013-06-26" version="1">MQIKQRTFIITGGASGLGLATSIDLYSQGGHIAILDLNPESGAAAIQQLLSSSSSSSSSDDKSNSPRAKFFSVDVTDTSSLQSAIDSAATWAQSQHAPLGGLIPAAGVGNPAKLLDKNLNPIPMDTIDFVIDVNLRGVLNTIRLTLPHLARNEPWGPDGERGVIVMVSSSSAFEGQIGQLSYAATKGAIRSMTLVLARDLAGNGIRAVSVAPSLFETNMSKMLPEKVQLALRRQAEWPKRLGRAEEFAGFVRCVIENGYMNGECYRLDAATRMTARM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGT2</accession>
    <name>N1QGT2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phytanoyl-CoA dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_112438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764511.1">
        <property type="nucleotide sequence ID" value="XM_016900980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGT2"/>
    <dbReference type="GeneID" id="27898117"/>
    <dbReference type="eggNOG" id="ENOG502QZ63">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049199_0_0_1"/>
    <dbReference type="OMA" id="HEDFVWK"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31630:SF6">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31630">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF16390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="37832" checksum="3EF369925E28B1BA" modified="2013-06-26" version="1">MSSSSPSKPQFLIDLDRDGYVVVPSVVPPSVCASFVESAWSWLESFPTNNFSRTDRSTWKASHLPSDHSKGLYNRYSVNHEAFVWNIRTQPGILETFSQIWGTDDLIASFDGLNISLPVHPEHGRTDVEETKPWEHIDQDPRTISECKLYQGIANLADNGPSDGGLVVLAGSHKLHQRHFDAVNGGKFRPECDLGEGENGYNFNPEDAAWYREVAGCPEVKVCAKAGDLILWDSRTIHWNTNPKGERTRFATYVCYCPRSFMTEEELEKKREIFEQRKGTTHWPNMNIVPADKVDYYDAKPRRPDGSLDPADRTRPFHEPEVTPEVLRLVGVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1QH57</accession>
    <name>N1QH57_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2293 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_145746</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764641.1">
        <property type="nucleotide sequence ID" value="XM_016903243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QH57"/>
    <dbReference type="GeneID" id="27900380"/>
    <dbReference type="eggNOG" id="ENOG502SQ7Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_395457_0_0_1"/>
    <dbReference type="OMA" id="RIRHEYT"/>
    <dbReference type="OrthoDB" id="5288828at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018744">
        <property type="entry name" value="DUF2293"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38113">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38113:SF1">
        <property type="entry name" value="DUF2293 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10056">
        <property type="entry name" value="DUF2293"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2293" evidence="2">
        <location>
            <begin position="172"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF16520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="697" mass="78023" checksum="8B1A4859DDD3F44B" modified="2013-06-26" version="1">MTASTARASSAQPASAARGILKRREKPYKTEQSRIVARRRKLDLHMTYMAAPPGFQFLPVGTPDLADRCKELSRQRGLPVNVVNAKPVSFSATDPGKISHHIHRIGYHFRSDVVDDACHELGYTYSKKRFVREADLQAQYENSRLARAMARHGFAWDQEPVKQENTEQVREAIKELFPRIPDQDLSAILERAWAQGTSRVGTNTNIELPRRVQLATIARIRHHYTDYDRLLRAFEWKEARAMVEPICLKKLIEWRGENEDDDDNEFEEIVRETIVIDDDDDVEPLQRASRTDDEDSTAEIDQGYASDTSLEISHKPAAVEDLGAEIHDERSRKFLDRHQPPPRNVQQRHIDVRQKIGLAREQMRKAPVQNQNVVHVHVPHDQIDGDTIMIEGQRFRKVPPPVEVHRSPVYYAAPQLSPQGITPGSPYGPPQQYPTQQLHSRPAAPSNGYAPHDQPVASIEPQDDLRRKAMASASALQHNGYASGHRSRPASPQGLSGKRRRLDTNGHNGVQPHAQPQYTSPTDRTYRLAETYIGSPILASKTRPRSADCGSPRADDHRPSTRGAPLPPSSYVAQQPLVRINDDPHRTGNGISSHMVSRSGFVDAQVAPIQYAPLSQHHTGHKGHLPRPPPGEEYYVQSGTRPATRVVYVESPQAGYGLPQPQHGAPAAVQPAHVNVAAKYAPPIAGDYAPQRYYYPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1QHG1</accession>
    <name>N1QHG1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_157771</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758714.1">
        <property type="nucleotide sequence ID" value="XM_016907751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QHG1"/>
    <dbReference type="STRING" id="692275.N1QHG1"/>
    <dbReference type="GeneID" id="27904888"/>
    <dbReference type="eggNOG" id="ENOG502SIZM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046553_0_0_1"/>
    <dbReference type="OMA" id="ELGPCPY"/>
    <dbReference type="OrthoDB" id="2831558at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF13">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="84"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF10593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="432" mass="48303" checksum="F9D4912791A68311" modified="2013-06-26" version="1">MVSPTKENINDANAANRLEFVKQTVAETFGFQVLKVTPIAYEEDFPFPYNNFVFAVHINRESTPSKETLRAKQPGCQTIPVDEETFICRIPNPLSGYNDKVRVQNEVAALSLAREALQPSLLSHLVPRVYGWASAENGGYGWILQQYMSGTGPLAEFSSWSEEDKANILDQMADVLACLQRFQLPSTIDRYGGVGFDAEGNYVNTALSMYDAGPFETYPELLRATITSKLIKADGDSRVRGWRDNGIRARLDEFLNRGLPTLLQGVASLDKVLVHADFSLDNILYDQSSKKLTAIFDFDFAHISSVADEFFRSLGHDIGRFPCIRDEIPEELQLHQAMLHGFPQPLPTNTTDEVDWIAAKAWDDAIAVRGVQRPATLPSMDLVSDLFWLSSRILPFRLCNEVVVGNSTEEQLALRKTDGEALLSKFLSDYGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>N1QI77</accession>
    <name>N1QI77_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_129799</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765072.1">
        <property type="nucleotide sequence ID" value="XM_016902308.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.N1QI77"/>
    <dbReference type="GeneID" id="27899445"/>
    <dbReference type="eggNOG" id="KOG1178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_60_0_1"/>
    <dbReference type="OrthoDB" id="3641063at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd19545">
        <property type="entry name" value="FUM14_C_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003417">
        <property type="entry name" value="PRK04813.1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF16">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHASE ATNA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="832"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="1985"/>
            <end position="2060"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="3143"/>
            <end position="3221"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="4296"/>
            <end position="4373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="4375"/>
            <end position="4405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="4837"/>
            <end position="4858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="4377"/>
            <end position="4387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="4392"/>
            <end position="4405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF16951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="4858" mass="535872" checksum="FD831063F1378AF1" modified="2013-06-26" version="1">[encoded data, 4858 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>N1QI80</accession>
    <name>N1QI80_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rpr2-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_111127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757800.1">
        <property type="nucleotide sequence ID" value="XM_016900898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QI80"/>
    <dbReference type="STRING" id="692275.N1QI80"/>
    <dbReference type="GeneID" id="27898035"/>
    <dbReference type="eggNOG" id="ENOG502SC64">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1256724_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="22787" checksum="9F5EE085B9AE4312" modified="2013-06-26" version="1">MTSHLATARAAHLQASSEALMTTSPSISAYLQIQLFHDGKPTTTRRTTQPCSSCGTFLFPGYNSSITNAKKRTRQDRLAGKFSAAKILKCSTCETTHQILPAATTAAKTTTTKPTGIKKRGITSGGGNSATASSSSTTAAATSIAQPSESEYNSPSGLSASSIISTTTASKSRNRKNKKSSLQALLSSNRSNITTGTSIGTSTSTTSKKGFGLGLGDFMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1QID9</accession>
    <name>N1QID9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">L-lysine 2,3-aminomutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_112978</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765076.1">
        <property type="nucleotide sequence ID" value="XM_016901008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QID9"/>
    <dbReference type="STRING" id="692275.N1QID9"/>
    <dbReference type="GeneID" id="27898145"/>
    <dbReference type="eggNOG" id="ENOG502QWPC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032161_3_0_1"/>
    <dbReference type="OMA" id="FCFRWAQ"/>
    <dbReference type="OrthoDB" id="5396721at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003739">
        <property type="entry name" value="Lys_aminomutase/Glu_NH3_mut"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30538:SF0">
        <property type="entry name" value="L-LYSINE 2,3-AMINOMUTASE AQ_1632-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30538">
        <property type="entry name" value="LYSINE 2,3-AMINOMUTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01070">
        <property type="entry name" value="PLP-dependent"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF16955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="452" mass="51365" checksum="E3489BE45E690B10" modified="2013-06-26" version="1">MALKVLSKSSIPSIFRKHCPSINHLPYLAAAQVFPMRVNSHVVNNLIDWSKVPHDPIFRMTFPHPDMLQDGDREKICSMLLQHASRLEIRRVAEHIRKRLNPHPAGQQQENIPRFRGKPVFGMQHKYRETVLFFPLEGQYCHAYCSYCFRWAQFTSVGSPQTFQSNSRTTLPEYIRAHPSVTDVLFTGGDPLIMSTKLLQTYILPLLPQNHGPRNLKTIRIGTKALTWWPRRFLDDGDGENDAKQLLRLLEDIVASGIHVSIQAHVSHARELLDPDTQAAIRALRSTGAVIRCQAPLMRHVNDSASAWADMWRLQTSLGTIPYYMFVERDTGAADYFAVPLTSAFEIYSTASSMVSGLSRTARGPSMSTSPGKICVRGIETISQQKVFVLQFVQSRNPQWCHRTFFAEYDSSAVWFDQLKPAFGEEGFFFESEYEEIRARAAQESSGQIFQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1QIM8</accession>
    <name>N1QIM8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Reduced viability upon starvation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_146177</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765202.1">
        <property type="nucleotide sequence ID" value="XM_016903502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QIM8"/>
    <dbReference type="STRING" id="692275.N1QIM8"/>
    <dbReference type="GeneID" id="27900639"/>
    <dbReference type="eggNOG" id="KOG3771">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025518_0_1_1"/>
    <dbReference type="OMA" id="QEYDYYN"/>
    <dbReference type="OrthoDB" id="2159336at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990528">
        <property type="term" value="C:Rvs161p-Rvs167p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07599">
        <property type="entry name" value="BAR_Rvs167p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000048">
        <property type="entry name" value="BAR adaptor protein RVS167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000189">
        <property type="entry name" value="BAR adaptor protein RVS167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF1">
        <property type="entry name" value="REDUCED VIABILITY UPON STARVATION PROTEIN 167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="BAR" evidence="8">
        <location>
            <begin position="17"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="361"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="300"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF17081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="421" mass="47916" checksum="EC1FD64568EF6AF6" modified="2013-06-26" version="1">MSWKGFTKGAVRAPQLVKQRFNIGEITKDPIYIDAERRFADLENETKKLHDESKKYFDAINGMLDHQIEFSKACAEIYKPISGRASDPDSYVIDGNPEGIRACEEYEQIVQELKASLAPELEMIETRVVKPADELMEIIKVVRKACVKRDHKQVDYDRHQATLKSLQEKKDKSLKDEKALYKAENNVEMATQEYEYFNNLIKEELPQLFRLEKEFILPLFQSFYYMQLNVFYTLHEKMQSIDIGYFDLTKGIEESFEEKRGDIQQQVEALSMVKFKTTGGPRKPAALKYGNRLAITNGKAEPENRRLTIDGNAPPAYDTKPLSTSLVQRASSTGSNWTSAAKAKGAPPPPKPKPGRLSVMPATEQVTALYDYDAQAEGDLSFKTGEIIEIVSRTDNQNEWWTGKIGVRQGQFPGNYVQLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>N1QIP6</accession>
    <name>N1QIP6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">U6 snRNA-associated Sm-like protein LSm1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LSM1</name>
        <name evidence="14" type="ORF">SEPMUDRAFT_146166</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the cytoplasmic LSM1-LSM7 complex which is involved in mRNA degradation.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the heptameric LSM1-LSM7 complex that forms a seven-membered ring structure with a donut shape.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with SLBP; interaction with SLBP occurs when histone mRNA is being rapidly degraded during the S phase. LSm subunits form a heteromer with a donut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
            <location evidence="11">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765186.1">
        <property type="nucleotide sequence ID" value="XM_016903492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QIP6"/>
    <dbReference type="STRING" id="692275.N1QIP6"/>
    <dbReference type="GeneID" id="27900629"/>
    <dbReference type="eggNOG" id="KOG1782">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076902_0_1_1"/>
    <dbReference type="OMA" id="RTWDQFA"/>
    <dbReference type="OrthoDB" id="10263346at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01728">
        <property type="entry name" value="LSm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000021">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034104">
        <property type="entry name" value="Lsm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044642">
        <property type="entry name" value="PTHR15588"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588">
        <property type="entry name" value="LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588:SF8">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 11" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Sm" evidence="13">
        <location>
            <begin position="26"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00056858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMF17065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="155" mass="17680" checksum="AD6067BEB4A898C6" modified="2013-06-26" version="1">MENLSLHDAGPLMPQGPPQLPPQMFTTAAQLLDLTDKKLMVALRDGRKLIGVLRSWDQFGNLVLQDTVERLFVHHLYADIERGLFLVRGENVLLLGEIDLDKDDYVPEPFEQASAEKVFQLKKLEEQKRKQTDKVKQKKLAELGFEGEHSGEVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJC0</accession>
    <name>N1QJC0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_146357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765411.1">
        <property type="nucleotide sequence ID" value="XM_016903597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJC0"/>
    <dbReference type="STRING" id="692275.N1QJC0"/>
    <dbReference type="GeneID" id="27900734"/>
    <dbReference type="eggNOG" id="ENOG502TB37">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_792328_0_0_1"/>
    <dbReference type="OMA" id="LTPLCMR"/>
    <dbReference type="OrthoDB" id="3629846at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110913" description="Peptidase A1 domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF17290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="30516" checksum="61054DB5D47D5DE8" modified="2013-06-26" version="1">MASRRSIIAALVASSGLVAAQNATAFSGPGPYPEGQSFLDDAQVTTEKTVSFDLFYPNEGNAPRWQLITRLEQAAPPDSAIPDASVLNTVYDFGYPNGGNLSEAVAASSGQLNQNNFCVTILESLLPSKEANRYNADTESNASDGSCRYALRDQCLNAINDRVAKTQPADNGCRLSNLNVTDIVQCEWIFNEETKLSTYNLLAPELAGNLTGGFAHITSDPFDAGNTTFLDIAETRVHMVVIDSGSTFTPLCVKIDAERDQVGSASIARVSMGLVAAAIGTVVYAMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1QL44</accession>
    <name>N1QL44_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cell wall protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_129303</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764459.1">
        <property type="nucleotide sequence ID" value="XM_016902274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QL44"/>
    <dbReference type="STRING" id="692275.N1QL44"/>
    <dbReference type="GeneID" id="27899411"/>
    <dbReference type="eggNOG" id="ENOG502SSUM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_855725_0_0_1"/>
    <dbReference type="OMA" id="HSHEMTA"/>
    <dbReference type="OrthoDB" id="311712at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021054">
        <property type="entry name" value="Cell_wall_mannoprotein_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38123">
        <property type="entry name" value="CELL WALL SERINE-THREONINE-RICH GALACTOMANNOPROTEIN MP1 (AFU_ORTHOLOGUE AFUA_4G03240)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38123:SF6">
        <property type="entry name" value="CELL WALL SERINE-THREONINE-RICH GALACTOMANNOPROTEIN MP1 (AFU_ORTHOLOGUE AFUA_4G03240)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12296">
        <property type="entry name" value="HsbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110962" description="Cell wall protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF16338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="325" mass="32557" checksum="FCEB66FD8FF0984A" modified="2013-06-26" version="1">MKFTVALFAIGALAAVRRQTGDLASNVQAITDATKKVTTAIEGYNGDVQQAAAVESASSDVLAAIKSAQSTVDGMSTIDQSAAITLAIPIKDLSSAVDASITALIGKKDAFDKAGLSSLVLSSLQDQKKASDALTSALLGKLPEALQDTGKQLAKPAQDSLDKGIAAFSSGGGGGGDMKPAGDMKPSGDMKPAGAVPPPPMDMGAPASPPEAAPPAPSSAAEYPSPTMPPAGMTPPAEAPSSTSSCPETTTMMPSMPMMPSMSTMMSMETTTSMPMMSTMPTMHPTMSTSMNASTTTMPVSYTGAAHQQAVGLGALAVGALVAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>N1QLV0</accession>
    <name>N1QLV0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">N-terminal acetyltransferase A, auxiliary subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_146290</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765308.1">
        <property type="nucleotide sequence ID" value="XM_016903556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QLV0"/>
    <dbReference type="STRING" id="692275.N1QLV0"/>
    <dbReference type="GeneID" id="27900693"/>
    <dbReference type="eggNOG" id="KOG1156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006686_1_1_1"/>
    <dbReference type="OMA" id="MEMRADY"/>
    <dbReference type="OrthoDB" id="10263032at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010698">
        <property type="term" value="F:acetyltransferase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1040:FF:000003">
        <property type="entry name" value="N-terminal acetyltransferase A, auxiliary subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1010">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021183">
        <property type="entry name" value="NatA_aux_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011717">
        <property type="entry name" value="TPR-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767:SF2">
        <property type="entry name" value="N(ALPHA)-ACETYLTRANSFERASE 15_16, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12569">
        <property type="entry name" value="NatA_aux_su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07721">
        <property type="entry name" value="TPR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000422">
        <property type="entry name" value="N-terminal-AcTrfase-A_aux_su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="77"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="597"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="614"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="640"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF17187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="750" mass="85340" checksum="346C2AC3143078E8" modified="2013-06-26" version="1">MAQPLPSKEQTLFRHLVQNYESKQYKKGLKAAEQILKKHPSHGDTQSMKALILNNQGKSDEAFELCKLALKNAMRSHICWHVYGLLWRSVKNYEEAIKAYRFALRLDPDSVQIQRDLALLQVQMRDYPGFVQSRNQMLQSKPALRQNWTALAVALHLNGDLDKAEDVLQKYEETLKQPPAKNDMEHAEALLYRNTIIAETGDYKRALEHLESIQKSALDKTAVKEAKAAYLLKLGRKDDAEKAYRALLHRNVEKRAYYHGLEAALGLDRTKSEDHEKLLAVYQSFADKSSRTDAARRIPLDFLRGDAFRQHADSYLRRALAKGVPSTFANVKQLYADEDKRRTIQGLVEGYLEEEAQVNGGAEAQEVNGTTNGTAKPGSAQQSATWSLSVNYFLAQHYNYYLSRDLDKAQQHIEKAISLNTSKSDYTYQMTRARILKNQGDVGAASKAMNAAREMDLRDRYINTKCAKYQLRNDEHQAAIDTMGLFTRNEAVGGPLGDLLDMQCVWYITEDGESYLRQGNLSLALKRFKAVYDIFEVWTEDQFDFHTFSLRRGMMRAYIEMIRWEDKLREHPFFTRAALSAIKIYCMLFDRPELAQASPQSEADKKKAAKKARKESEKAEADRKAAAAKKANAKGDDDEAARKEDKDPQGLDLLKQAGEKPLEEAMKYVTPLLELSPRNIHAQTAGFEVYIRRKKYLPALRCLLAVQSSDFDGTSTQEMANRLKLALEKSEEALPKDAQQAIEALLLSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2024-11-27" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1QM27</accession>
    <name>N1QM27_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_76612</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765039.1">
        <property type="nucleotide sequence ID" value="XM_016910148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QM27"/>
    <dbReference type="GeneID" id="27907285"/>
    <dbReference type="eggNOG" id="KOG1611">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_9_7_1"/>
    <dbReference type="OMA" id="NTWGTFN"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052184">
        <property type="entry name" value="SDR_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458:SF1">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF16918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="260" mass="28448" checksum="D20CC8FE1B6C273C" modified="2013-06-26" version="1">MPTILITGAASGLGAAFVQAYLNQPGNNNNKIIAIDKDPIPNLHLLPSKQVRFYKVDVSDESSIKSLQTALREGKEEEEEDEHEPIDLILHCAGVRGLVPEEEAAQTPTSKIISACESLEIMNLSTLTQTFSINAAGTFLLLRALLPHVQRAKGKVIVMSSRMGSIGNNQMPYSAAGASYAYRASKAAQNMLVRSLAVDVPDVTFVLCHPGRVETRLVKWKEEGAISAEESVRGLVPLIEKWGKEDSGKFYDRFGEPIQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1QM28</accession>
    <name>N1QM28_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chromosome transmission fidelity protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_21408</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CTF8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764490.1">
        <property type="nucleotide sequence ID" value="XM_016908336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QM28"/>
    <dbReference type="STRING" id="692275.N1QM28"/>
    <dbReference type="GeneID" id="27905473"/>
    <dbReference type="eggNOG" id="KOG4487">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090690_0_0_1"/>
    <dbReference type="OMA" id="YLYVGKH"/>
    <dbReference type="OrthoDB" id="121932at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018607">
        <property type="entry name" value="Ctf8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28605:SF1">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28605">
        <property type="entry name" value="CTF8, CHROMOSOME TRANSMISSION FIDELITY FACTOR 8 HOMOLOG (S. CEREVISIAE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09696">
        <property type="entry name" value="Ctf8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF16369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="132" mass="14752" checksum="BBB5017E72F71836" modified="2013-06-26" version="1" fragment="single">MPTVTLRPPVRDRATISTNGNPMPSLVQTPSGLAMMELQGIISSEEPELETALHLGRLVFPPAEGDEHGEWDGKRVMLYVGDHQRLTGEVKKLAKPIAVLRRRPTSSIVDEEVEIAEIVYYKMLFAHRPEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1QMB8</accession>
    <name>N1QMB8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phosphate transporter A-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_146156</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765174.1">
        <property type="nucleotide sequence ID" value="XM_016903484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QMB8"/>
    <dbReference type="STRING" id="692275.N1QMB8"/>
    <dbReference type="GeneID" id="27900621"/>
    <dbReference type="eggNOG" id="KOG0252">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_46_13_1"/>
    <dbReference type="OMA" id="PDGVYWA"/>
    <dbReference type="OrthoDB" id="433512at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="454"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="487"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="515"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="102"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF17053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="625" mass="70418" checksum="E57B45A725C06DA4" modified="2013-06-26" version="1">MTDASMRDYGIAAPHGPNMGGQHVATADLGDMKHNESEVFRSLLLPDDSYDENGTYWADMKVAQRLKFVNKVDSAEAKKEVQSIGRMMKADPLSPVSYYFRNMVIPGMGLLLEGYVLFSIGNVKPLFTAAFPDCWHNYKVCTKTWVQAVDYLEILGIIVGQILVGVLGDWLGRRWGLIQDAVIMFLGLIMLTASWGTTLNGWVICYTWSLFFYGIGVGGEYPMTATSGMENAVGAGKISTREDRLHRGRKVTSAFLMQGWGQWANQVILILLLLIFHGGKSGAPYNKTLVQWTYRVSFAIPAVGTLWLCYYRTYKMRSASKVLQQAKKKQSVTGYDVKSLSYTFTYFGGRVFATAAAWYANDVFFYGNKLFQAEFISTLSGDTSSVMVNWLWNLLNIGVSLVGYYLASFLIDNKNYGRKWMQIVGFMGDFICFIIPAFNYSYYAEGAGVHKFMAMYFLSSFFNQFGPNSVTFLVAAEVFPTPVRASAHGFSAACGKLGALTAAVLYNYIDVPTRFMVVPWFGLAGALITFVFLPDTTGLDLKEQERRWAYIRAGRENEYHGVAIHPQHLSLWERMRGGAKNYNAQKDYEQRVEEMRADWEAAMARRVAEKEGAQDEVDEDNWYVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1QMQ7</accession>
    <name>N1QMQ7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein phosphatase PP2A regulatory subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_146362</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphatase 2A regulatory subunit A family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765419.1">
        <property type="nucleotide sequence ID" value="XM_016903602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QMQ7"/>
    <dbReference type="STRING" id="692275.N1QMQ7"/>
    <dbReference type="GeneID" id="27900739"/>
    <dbReference type="eggNOG" id="KOG0211">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015533_2_1_1"/>
    <dbReference type="OMA" id="NRVEAMQ"/>
    <dbReference type="OrthoDB" id="340346at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090443">
        <property type="term" value="C:FAR/SIN/STRIPAK complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110085">
        <property type="term" value="C:mitotic actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030952">
        <property type="term" value="P:establishment or maintenance of cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990813">
        <property type="term" value="P:meiotic centromeric cohesion protection in anaphase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031030">
        <property type="term" value="P:negative regulation of septation initiation signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000011">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A regulatory subunit A alpha isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055231">
        <property type="entry name" value="2AA_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054573">
        <property type="entry name" value="PP2A/SF3B1-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051023">
        <property type="entry name" value="PP2A_Regulatory_Subunit_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648:SF4">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2 (FORMERLY 2A), REGULATORY SUBUNIT A, BETA ISOFORM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A 65 KDA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22646">
        <property type="entry name" value="PPP2R1A-like_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22956">
        <property type="entry name" value="VPS15-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="12"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="89"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="205"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="246"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase PP2A regulatory subunit A/Splicing factor 3B subunit 1-like HEAT repeat" evidence="4">
        <location>
            <begin position="279"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="285"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="324"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="363"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase 2A Regulatory Subunit A helical" evidence="5">
        <location>
            <begin position="369"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="402"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="519"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF17298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="620" mass="69361" checksum="5164045A7462B7DD" modified="2013-06-26" version="1">MEERGAQDELYPIAVLIDELKHDDVLLRLNAIRRLSTIALALGPERTREELIPFLDESVEDEDEVLTALGDELGNFVEYVGGPDYGHVLLSPLENLATIEEPLVRDKAVESLNKICEQLSQQQVEQYFIPLTIRLSKADWFTSKISATGLYNTPYQHATPQSQEGLRQQFHQLVHDDTPMVRRQAANNLAKFVKSMPAAVVIEDMIPLFQHLAGDDQDSVRLLTVEVLIAIAEAVPKEQQSSHGVLLTALRSLFEDKSWRVRYMVADRFEKVAKAVDDEVIARDLVPAFVKLLKDNEAEVRSAVAGQIPGFCRLVDRQALLRDIMPAIEDLVSDSSQHVRAAFGNQISGLAPILGKQETTEHLLPMLLQMLKDDFPEVRLNIISKLEQVNNVIGIELLSQSLLPAIVQLAEDKQWRVRLAIIQYVPLLASQLGVKFFDEKLSTLCMSWLGDTVFSIREASTQNLKKLTEVFGVEWASEAIVPKVAAMAEHPNYLYRMTTCFAVSILAPALSLPVVAQSVLPILQTLVNDPIPNIRFNVAKSYAVLIDILKRLPDSPSATIVDLEKQGETNFPGSPRGQQLIRDEVMPPLEKLMQDDDIDVRYFATTASKAWMDTESAMET</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1QMV0</accession>
    <name>N1QMV0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cell wall protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_146684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765833.1">
        <property type="nucleotide sequence ID" value="XM_016903797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QMV0"/>
    <dbReference type="STRING" id="692275.N1QMV0"/>
    <dbReference type="GeneID" id="27900934"/>
    <dbReference type="eggNOG" id="ENOG502RV8Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_909639_0_0_1"/>
    <dbReference type="OrthoDB" id="2422134at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021054">
        <property type="entry name" value="Cell_wall_mannoprotein_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000420">
        <property type="entry name" value="Yeast_PIR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38123">
        <property type="entry name" value="CELL WALL SERINE-THREONINE-RICH GALACTOMANNOPROTEIN MP1 (AFU_ORTHOLOGUE AFUA_4G03240)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38123:SF6">
        <property type="entry name" value="CELL WALL SERINE-THREONINE-RICH GALACTOMANNOPROTEIN MP1 (AFU_ORTHOLOGUE AFUA_4G03240)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12296">
        <property type="entry name" value="HsbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00399">
        <property type="entry name" value="PIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50256">
        <property type="entry name" value="PIR_REPEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF17712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="31191" checksum="2256A322B5681B35" modified="2013-06-26" version="1">MKFLQASLFITQAIAFSLDTRSPALISRQAATDIASSIATIQAATQSLNTAVSFGDLLALTSANSAVVNAIKAATSEANGLSTPLKFDDATTLSTPIKDLGKVFDSTITKLIGKSSSMIDARQTILSGLESQLSASAAFSTALSRKVPDHLQSTAMSLAQPIADSLARGIAEYSKRSIGGRLEIRKAAPAGAIVTQIADGQIQAPKGSVLPTVSASIMTASIIPASIIPASVLPVTASVLPISPSTISSTIPTKASSAISSAISTAISKSSISNIPAAYVMPTLSTITGIPSYSLPGCTTPTNRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>N1QN08</accession>
    <name>N1QN08_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_57899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765579.1">
        <property type="nucleotide sequence ID" value="XM_016909452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QN08"/>
    <dbReference type="GeneID" id="27906589"/>
    <dbReference type="eggNOG" id="ENOG502RWIM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_711688_0_0_1"/>
    <dbReference type="OMA" id="QHVESNI"/>
    <dbReference type="OrthoDB" id="3795850at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF17458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="349" mass="38678" checksum="4FDE35D63D9C901A" modified="2013-06-26" version="1">MAHNRLTAGLAWATPVRPDELGQRLEHYAGVLPTLKGLRLCHRFGQGQDAHVTRLPVEVELAIEAIIIQDKQSPSQHGREKWADKFRHYEGRCSPTDHEGFSFSDDLSDWTPCGKCDGIPDVELCELRCQPGALSPCHTCSQKLDPGNCMKSCDALQFADRDSYAEDFGSSGSCPYQAQMYESWEEAIDQTGAFARYDTILEEQFGLKAFFAPSRISIEDVDIWPRHRNHQFHEMDQLRTTICYLTVSQTLAPKKTAITSTVEHAGGYPCDLSSVQVIKLGQPSFALTNTVKKRFQRALDILNLKAYVHPSQGTSLVMPTLSGPNQGESPSVPPGQSTTGLHCVILAID</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNY5</accession>
    <name>N1QNY5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Kynurenine formamidase</fullName>
            <shortName evidence="3">KFA</shortName>
            <shortName evidence="3">KFase</shortName>
            <ecNumber evidence="3">3.5.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Arylformamidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">N-formylkynurenine formamidase</fullName>
            <shortName evidence="3">FKF</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_146760</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>N-formyl-L-kynurenine + H2O = L-kynurenine + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13009"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:58629"/>
            <dbReference type="EC" id="3.5.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="domain">
        <text evidence="3">The main chain amide nitrogen atoms of the second glycine and its adjacent residue in the HGGXW motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the kynurenine formamidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.9" evidence="3"/>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765950.1">
        <property type="nucleotide sequence ID" value="XM_016903847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNY5"/>
    <dbReference type="STRING" id="692275.N1QNY5"/>
    <dbReference type="ESTHER" id="sphms-n1qny5">
        <property type="family name" value="Kynurenine-formamidase"/>
    </dbReference>
    <dbReference type="GeneID" id="27900984"/>
    <dbReference type="eggNOG" id="ENOG502S40A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016852_1_0_1"/>
    <dbReference type="OMA" id="YWVIYIH"/>
    <dbReference type="OrthoDB" id="420264at2759"/>
    <dbReference type="UniPathway" id="UPA00333">
        <property type="reaction ID" value="UER00454"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03014">
        <property type="entry name" value="KFase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049492">
        <property type="entry name" value="BD-FAE-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027519">
        <property type="entry name" value="KFase_ver/fungi-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF33">
        <property type="entry name" value="KYNURENINE FORMAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20434">
        <property type="entry name" value="BD-FAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0823">Tryptophan catabolism</keyword>
    <feature type="domain" description="BD-FAE-like" evidence="4">
        <location>
            <begin position="39"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="HGGXW" evidence="3">
        <location>
            <begin position="49"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF17829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="305" mass="33958" checksum="C59ABB7FF5D50A72" modified="2013-06-26" version="1">MGVTLTDEWPQFRTDIHYGNASSLNTLQTCIPRPTSANDQKRIWVVYIHGGAWFDPEQTATTFDKAQNILLKSHAEEHIAGFASINYRLSPAPWHPTSPSNPGDPARNASHPDHINDVLAGILHLQETYRFEGRYLLVGHSCGACLALQVLMKRYWGVQYESTAALQLNVVPPLAVLGIEGLYDLPALVRYHSDSAFYRNFVEAAFGPKEANWKAASPTSADLGASWEDGKLVVIAHSREDELVEWEQPDLMMKSLSSQGFKTSGSRRARLLELKGKHDQVWEEGVEVARAIEFAVKDFVSMGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M3AR35</accession>
    <name>M3AR35_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Plant senescence-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_55176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456278">
        <property type="protein sequence ID" value="EMF07914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AR35"/>
    <dbReference type="STRING" id="692275.M3AR35"/>
    <dbReference type="eggNOG" id="ENOG502S18N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112614_2_1_1"/>
    <dbReference type="OMA" id="CTRTESQ"/>
    <dbReference type="OrthoDB" id="3703354at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052997">
        <property type="entry name" value="RRT15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33047">
        <property type="entry name" value="PROTEIN TAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33047:SF8">
        <property type="entry name" value="REGULATOR OF RDNA TRANSCRIPTION PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF07914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="147" mass="15602" checksum="876CA2F4F56737B2" modified="2013-05-01" version="1">MIGRADIEGSKSNVAMNAWLPQASSSICGSGSPVGGPDAVAYICVYPCGNFSGTSSLKFRGTKGSIGHTFMVCIHTENQNQGDFCPFALLEISVLHESPLGHLRYGLTDVPPQPNSPPDNVINPDRPAKDLNARKWSVKTSSASLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M3AU45</accession>
    <name>M3AU45_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1,3-beta-glucan synthase</fullName>
            <ecNumber evidence="3">2.4.1.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">1,3-beta-D-glucan-UDP glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SEPMUDRAFT_151870</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;3)-beta-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;3)-beta-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21476"/>
            <dbReference type="Rhea" id="RHEA-COMP:11146"/>
            <dbReference type="Rhea" id="RHEA-COMP:14303"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37671"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.34"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 48 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.34" evidence="3"/>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF09004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757125.1">
        <property type="nucleotide sequence ID" value="XM_016907093.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.M3AU45"/>
    <dbReference type="GeneID" id="27904230"/>
    <dbReference type="eggNOG" id="KOG0916">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000844_0_1_1"/>
    <dbReference type="OMA" id="AWTDFFI"/>
    <dbReference type="OrthoDB" id="1880850at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000148">
        <property type="term" value="C:1,3-beta-D-glucan synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003843">
        <property type="term" value="F:1,3-beta-D-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006075">
        <property type="term" value="P:(1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051278">
        <property type="term" value="P:fungal-type cell wall polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026899">
        <property type="entry name" value="FKS1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056261">
        <property type="entry name" value="FKS1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003440">
        <property type="entry name" value="Glyco_trans_48_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741:SF48">
        <property type="entry name" value="1,3-BETA-GLUCAN SYNTHASE COMPONENT FKS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741">
        <property type="entry name" value="LYST-INTERACTING PROTEIN LIP5 DOPAMINE RESPONSIVE PROTEIN DRG-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14288">
        <property type="entry name" value="FKS1_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23605">
        <property type="entry name" value="FKS1_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02364">
        <property type="entry name" value="Glucan_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01205">
        <property type="entry name" value="FKS1_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="511"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="545"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="587"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="613"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="674"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1351"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1403"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1520"/>
            <end position="1538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1614"/>
            <end position="1635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1655"/>
            <end position="1681"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1693"/>
            <end position="1715"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1727"/>
            <end position="1750"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1791"/>
            <end position="1816"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1850"/>
            <end position="1874"/>
        </location>
    </feature>
    <feature type="domain" description="1,3-beta-glucan synthase component FKS1-like" evidence="13">
        <location>
            <begin position="354"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="98"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="154"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="305"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1894"/>
            <end position="1923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="167"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="305"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1894"/>
            <end position="1907"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMF09004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1939" mass="222340" checksum="019FEB5DA594A1BB" modified="2013-05-01" version="1">MAQPHQGAYDDGYGAQHPHDPHAAQDGYYQDGQAYYDQHGAAYGQGQHDGYYDDNGYYQAQPGQEGYAQDGYYDAPGQQGYQDEYYNDQYYDQGAPAAGQYQQQGRAYAGQRRSGRRGHDSEEDSETFSDFTMRSDMARAAEMDYYGRGDERYNSYGDGTGRGYRPPSSQVSYGGNRSSGASTPVYGMDYTSALPAGQRSREPYPAWTSDAQIPLSKEEIEDIFLDLTAKFGFQRDSMRNMFDHLMTLLDSRASRMSPNQALLSLHADYIGGENANFRRWYFAAHLDLDDAVGFANMKLGKANRATRKARKAAKKKKDANPENEEATLESLEGDNSLEAAEYRWKTRMNRMSQHDRTRQIALYLLCWGEANQVRYMPEIMAFIFKCADDFYHSPACQNRVEPVEEFTYLNKCITPLYTYCRDQGYEIYEGKYVRKERDHQKVIGYDDMNQLFWYPEGIERIVFEDKTRLVDLPPAERYERLGDVIWKKAFFKTYKETRSWFHMLTNFNRIWIIHVCVFWFYTAFNSPTLYTANYQQQLNNKPHGAAQWSAVALGGTLGCLIQILATLVEWMYVPRRWAGAQHLTKRLFFLLGMFVLNLAPAVYIFGINQKGKIALILGVVQFLIALGTVFFFAIMPLGGLFGSYLNGKRRQYVSSQTFTASYPRLEGNDMWMSYGMWVLVFAAKLAESYFFLTLSFRDPIRILSTMDIQNCLGDQIIGTILCYHQPTVLLILMYFTDLILFFLDTYLWYVIWNCVFSVARSFYLGVSIWTPWRNIFSRLPKRIYSKILATTDMEIKYKPKVLISQIWNAIVISMYREHLLAIDHVQKLLYHQVPSEQEGKRTLRAPTFFVSQEDHSFKTEFFPSQSEAERRISFFAQSLSTPIPEPLPVDNMPTFTVMIPHYGEKILLSLREIIREDEPYSRVTMLEYLKQLHPHEWDCFVKDTKILADETSQFNGDYEKNEKDTQKSKIDDLPFYCIGFKSAAPEYTLRTRIWASLRSQTLYRTISGFMNYSRAIKLLYRVENPEVVQMFGGNSDKLERELERMARRKFKIVVSMQRYAKFSKEERENAEFLLRAYPDLQIAYLDEEPATQEGEDPRLFSALIDGHSELMENGMRRPKFRVMLSGNPILGDGKSDNQNHCLIFYRGEYIQLIDANQDNYLEECLKIRSVLAEFEEMTTDNVSPYTPGLPPTKFNPVAILGAREYIFSENIGILGDVAAGKEQTFGTLFARTLAQIGGKLHYGHPDFLNGIFMTTRGGVSKAQKGLHLNEDIYAGMNAILRGGRIKHCEYYQCGKGRDLGFGSILNFTTKIGTGMGEQMLSREYYYLGTQLPLDRFLSFYYAHPGFHINNLFVMLSVQLFMWCLLNLGALRHETIACRYNRDVPITDPLFPTGCANIVPIMDWVQRCIVSIFIVFFISFVPLTIQELTERGFWRAATRLAKHFSSLSPLFEVFVTQIYAYSLQQDLSFGGARYIGTGRGFATARMPFGVLYSRFAGPSIYLGARLLMMLLFGTLTVWGYWLLWFWVSLLALCISPFLFNPHQFAWADFFIDYREFLRWLSRGNTKAHSASWIGFVRLSRTRLTGFKRKALGEPSAKLSGDTPRSKFTNVFFSEIVGPLVLVAVTLIPYLFINAGVGVIPSNNTDGQNLKATSSLIRVAICAFGPIGVNAGVAGGFFAMACCMGPVLSMCCKKFGAVLAGIAHAIAVIMLLVFWEVMFFLESWSFVKALLGMIAVVAIQRFIFKLIIALALTREFRADTSNIAWWTGKWYALGWHTLSQPGREFLCKITEMGFFAADFCLGHVLLFFMLPALLVPYIDKFHSVMLFWLRPSRQIRPPIYSLKQSKLRRRRVIRYAILYFSMFVLFIILMVGPVIAKKLIDIPKIDIMELQQPSDWNNNDTTNSQTGTALGSGARPTARPSATREASRMMARMMMDAYQQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2022-12-14" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>M3AUM5</accession>
    <name>M3AUM5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_150922</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF09776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757897.1">
        <property type="nucleotide sequence ID" value="XM_016906475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AUM5"/>
    <dbReference type="GeneID" id="27903612"/>
    <dbReference type="HOGENOM" id="CLU_2401066_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF09776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="93" mass="9757" checksum="132CFDEB6E4D4FBF" modified="2013-05-01" version="1">MERGSAGRIPENQVHLGQVEESRRAVNKCSGLRASGSAEQGGIICVQSSTTPHLPLPLSLSLSLPLPLSAHLLPQFPISATTSPHPNTSPREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>M3AV06</accession>
    <name>M3AV06_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_90808</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF09906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758027.1">
        <property type="nucleotide sequence ID" value="XM_016910537.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.M3AV06"/>
    <dbReference type="GeneID" id="27907674"/>
    <dbReference type="eggNOG" id="KOG0054">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_27_1_1"/>
    <dbReference type="OMA" id="QVTDAWT"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18597">
        <property type="entry name" value="ABC_6TM_YOR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18606">
        <property type="entry name" value="ABC_6TM_YOR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000565">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002040">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000010">
        <property type="entry name" value="Multidrug resistance-associated ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF464">
        <property type="entry name" value="ABC-TYPE TRANSPORTER CICA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="407"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="485"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="517"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="924"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="959"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1038"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1062"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1152"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="207"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="635"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="928"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1239"/>
            <end position="1478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="578"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="862"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="587"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="866"/>
            <end position="878"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF09906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1513" mass="168188" checksum="B3A38663C33767BE" modified="2013-05-01" version="1">MSGSEARKALTESTVEAPGPQEPIQTEALAEEPLERVGPDAELNDEKQVDYEAVEETSSQDESDIEKRQSPPLARTRSDWTTATENSVATEGAQPPEQQPTRKRKWSEKLNPFKSKNPPPVPSERLASREQSAGFFSVLTFQWVGPLMTVGYQRSLELNDIWHVNPERSVDVMRTKLLTALEYRQGRKDWFQPLPMALYDTFKKEFWIGGICNFISAMLQVLSPFTLKYLISFAGEAYAASNGTQPAPNIGHGIGLVIGITCMQIIQSGCVNHFIYRGMMVGGQARSTLISTIFAKAMRLSGRARAGGAALTMEAEQPAFEPGSKEEKAYFKQKLKDDQKKKKDKKGVSGDGQGWGNGRIVNLMSVDTYRIDQACGMGHMIWTAPIQVLLTLALLCINLTYSALAGFAFICLMMPLLAFAIRSLMMRRKVINEITDQRVSLTQEIISSVRFVKYFGWEMSFISRLGEIRDREIGKISFLLSIRNGIMAVSMSIPIFASMLAFITYSTTMHNLNPAPVFSSLALFNALRIPLNLLPMVLGQVVDANASLKRIAEFLAAEEINDDSEWKDDAKNAIEIRGGGFTWERNTNQDEKEAPGADPKGRKQIAQEKKDAKSKAKEDKSASKLAEKQQMGVYPDSDNVAESVLDEQRAPFQINNVDLTVGRDELVAVIGSVGSGKTSLLAALAGDMRKTTGEVTFGANRAFCPQYAWIQNATVKENIIFGKDYNSKWYNEVIDACALRPDLEMLPAGDMTEIGERGITVSGGQKQRLNIARAIYFDADIVLMDDPLSAVDAHVGKHIMDNAICGLLKGKARVLATHQLHVLHRVDRIVWMKEGMIYKIATFPDLMENDAEFQKLMETTAQEEKHEDEELVNEDEVEDEKKEVKKKKKGKKPAAALMQQEERAVDSVGWSVYAAYIRASGGMWVAPLVLILLVISQGANIMTSLWLSYWTSGKWNLGLGVYIGVYAALGVAQAALMFAFSVVLTVYGTKSSKVMLNRAVTRVLRAPMSFFDTTPLGRITNRFSKDVDTMDNTLTDSIRMFSLTMCMILSVFILIIAYYYYFAIALAPLTVIFLFSASYYRSSARELKRHEAVLRSVLFARFSEAVNGISTIRAYGVQQQFANHVDESVDSMDGAYFLTFANQRWLSTRLDAVGNVMVFVVGILVVTSRFSVNPSTGGLVLSYILSIVQMIQFTVRQLAEVENNMNSTERVHYYGTELEEEAPLHLGEVPASWPEHGAIDFDNVQMRYRDGLPLVLKGLTMHVRAGERIGVVGRTGAGKSTIMSTLFRLVELSGGSISIDGVNIAKIGLHDLRSRLAIIPQDPTLFRGTIRSNVDPFNEHTDLELWNALRQADLVGAEQTMDDEGGRIHLDTAVEDEGLNFSLGQRQLLALARALVRGSQIIVCDEATSSVDFETDQKIQRTIVRGFKGKTLLCIAHRLKTIIGYDRILVMDQGNVAELDRPLTLYDQGGIFRSMCDRSGIRREDFFESAEARFSAESPELERTQSAVMTTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M3AW34</accession>
    <name>M3AW34_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zn-dependent exopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_151284</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758422.1">
        <property type="nucleotide sequence ID" value="XM_016906716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AW34"/>
    <dbReference type="STRING" id="692275.M3AW34"/>
    <dbReference type="GeneID" id="27903853"/>
    <dbReference type="eggNOG" id="KOG2275">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021802_3_0_1"/>
    <dbReference type="OMA" id="RLHKGVM"/>
    <dbReference type="OrthoDB" id="3064516at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050072">
        <property type="entry name" value="Peptidase_M20A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43808">
        <property type="entry name" value="ACETYLORNITHINE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43808:SF8">
        <property type="entry name" value="PEPTIDASE M20 DIMERISATION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004031581" evidence="6">
        <location>
            <begin position="20"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="7">
        <location>
            <begin position="196"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF10301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="420" mass="45339" checksum="382F9DC1E5CC1B0D" modified="2013-05-01" version="1">MRVIHLASAFTSLASSGSAALSSYTLLRPDVVRLHQSLVEIESISGHEQAVGDWLYHSLIQQGYHAEKQYVSRDPERFNVYAWPGENRDPPVMLTSHIDTVPPFLPYKYTKDEDHPGNSTIFGRGSVDAKGSVATQIIAINELIASSAISPDDVSLLYVVGEEIGGGGMRAANNLSLSHTQTIIFGEPTALHLVSGHKGTMQAIIRAKGKAGHSGYPWLGRSANEVLVSSLAAIMHLGDRLPTSAKYGSTTFNLGVLQGGVAANVIAQNATATIAVRIAHGTTSMIQHAMTQAIHEAVQPFLSGNGDDDDNHLTPQDIVELDFTGAGYGPVDIDHDVPGFDVITVNYGTDIPWLEKVVSDQKRYLYGPGTIFVAHGDQEELREKDLWEAVEGYQKIVLFALGKEGEGEGERESGEEKEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M3AY38</accession>
    <name>M3AY38_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_65430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760518.1">
        <property type="nucleotide sequence ID" value="XM_016909719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AY38"/>
    <dbReference type="STRING" id="692275.M3AY38"/>
    <dbReference type="GeneID" id="27906856"/>
    <dbReference type="eggNOG" id="ENOG502SPK2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_565212_0_0_1"/>
    <dbReference type="OMA" id="NRHAKAY"/>
    <dbReference type="OrthoDB" id="2522477at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055411">
        <property type="entry name" value="LRR_FXL15/At3g58940/PEG3-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24758">
        <property type="entry name" value="LRR_At5g56370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="22"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF12397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="483" mass="54491" checksum="EB0DF2DCD31B8B8A" modified="2013-05-01" version="1">MRLKSVFRRVTRKLAAMNATFRFALLELPTELIAQIIEHVDNRTTLKHLACTCRKIQELTEPVLYRSALIRDAVQMTNMLHSVVGNRPARAKAIHHLDVPCHPRSSPSFDDLGVLLENALNLRRLMVESPECNTGEFEDEDSYEHMARNLFRPFESAVCVNDVERRPLQRLQELVLHLNGKESPYWTIGRRCLSIFLLPSLQKLTLSCVNIEDDVVESIRDRSFTSLKHLTLEESNITHQGLIGILSLPKALETLYLGENCHNMTHFDQQLNPAANYLFRNDPGLTLQALSQQKDSLKALTYVATSYYQHRSLIRPPHSPTDAGFAEFRSLESVTLCGQCPNFERAVMSSQSPSGLKTLVFQTDEIYWAPLGPTASVSALDAIPFLRAPACSVPPALSTVRIVGREQDFTAAMKGRISSAAKEMLKLGVTLEVQVESRSTYFPPFLYGEPLPKATTVFDGTWRLTEHRPRTLWNDWGDSSSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M3AZY6</accession>
    <name>M3AZY6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Translation protein SH3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_148484</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell septum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-5A family. Hex1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761218.1">
        <property type="nucleotide sequence ID" value="XM_016904948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AZY6"/>
    <dbReference type="STRING" id="692275.M3AZY6"/>
    <dbReference type="GeneID" id="27902085"/>
    <dbReference type="eggNOG" id="KOG3271">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021655_0_0_1"/>
    <dbReference type="OMA" id="HEEPCVV"/>
    <dbReference type="OrthoDB" id="9975114at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140266">
        <property type="term" value="C:Woronin body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045901">
        <property type="term" value="P:positive regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045905">
        <property type="term" value="P:positive regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04469">
        <property type="entry name" value="S1_Hex1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000033">
        <property type="entry name" value="Woronin body major protein HEX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037318">
        <property type="entry name" value="Hex1_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001884">
        <property type="entry name" value="IF5A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048670">
        <property type="entry name" value="IF5A-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020189">
        <property type="entry name" value="IF5A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11673">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 5A FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01287">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21485">
        <property type="entry name" value="IF5A-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation initiation factor 5A-like N-terminal" evidence="4">
        <location>
            <begin position="78"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Translation initiation factor 5A C-terminal" evidence="3">
        <location>
            <begin position="151"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00061629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF13097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="224" mass="25109" checksum="CABCF24CCC4F8054" modified="2013-05-01" version="1">MGYYDDDGHYHSFRHGVRRAADRILHPFEGHSHHSHHHQHEGRSERIEEDIVVKDREITMSAPRGSYSAAPRSAGAPNTITIPCHHIRIGDLLILQGRPCQVIRITTSAQTGQHRYLGVDLFTKQLHEESSFVSNPSPSVVVQNMVGPVFKQYRVLDIRDDGAVVAMTETGDVKQGLPVLDQSNLLKRLQESFNDGRGSVRVLVINDDGRELAVDYKVVHGSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M3B0G2</accession>
    <name>M3B0G2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_148630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761398.1">
        <property type="nucleotide sequence ID" value="XM_016905042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B0G2"/>
    <dbReference type="STRING" id="692275.M3B0G2"/>
    <dbReference type="GeneID" id="27902179"/>
    <dbReference type="eggNOG" id="KOG4157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014722_2_0_1"/>
    <dbReference type="OMA" id="GVRWGCH"/>
    <dbReference type="OrthoDB" id="74764at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF12">
        <property type="entry name" value="DUF1996 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1996" evidence="2">
        <location>
            <begin position="37"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF13277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="477" mass="51210" checksum="2353B6A351486D51" modified="2013-05-01" version="1">MKTTMYAAAAALATTSSARQFVMYTPGGDSDLVERMDAIVSPGKISAHTHQIFGASGASPDMTYESLQKSDCTTVGNAAMAGNSQDKSVYWHPSLYAEAKNGTGYVRIPSGGHKMYYRDVGNSADQVASPFEFPKNFHMVAGDQTMRAANKDTKHQLITEWICHMSTGKLMGVDQKSGFPTDVSNCDSYPGFAGSIHFPHCWNGEAPKVNDNSHMSYPEGDPQGGPCPSTHPIRLPHIFMENFFDLDKVHDQIEPNTFVLSQGDPTGYGWHADFFNGWDEGAIPSLIESCPNPFYGNEDVGTCPTFKGFSMKSTDCKMKAHFEENSDTPGEYLPGCNPISKVNPAPKMAAAPLGVCSDECTPASAPNAGNAPSYNSSSPSSPSSSISPPSYGKPSSSTKPQAAATTLATAYSAPSPPAYVGAAKEAIKDAAKDAVDHAIEYVTHVVTVTADSYKRDAAPTPHKRHEHAHMRKHQRHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M3B224</accession>
    <name>M3B224_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transp_cyt_pur-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_65126</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761953.1">
        <property type="nucleotide sequence ID" value="XM_016909706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B224"/>
    <dbReference type="GeneID" id="27906843"/>
    <dbReference type="eggNOG" id="KOG2466">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021555_4_1_1"/>
    <dbReference type="OMA" id="RWHILYV"/>
    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11482">
        <property type="entry name" value="SLC-NCS1sbd_NRT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF0">
        <property type="entry name" value="PURINE-URACIL PERMEASE NCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="433"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="477"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="510"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF13832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="547" mass="60370" checksum="3965B777931C1E19" modified="2013-05-01" version="1">MNQTADPELVKHAVVNVDTQCVGPSLGESRSTHSWSTLLQRLRYSCQLETEIDKDGFRKWSNADLDPITSSGQTWTSINFVTYWLCDAIGPGNLRLGSSIVTLGLSWQTAVGIIALGHFLISLVITANGIIGARLHIPYTIQSRASFGFYCSFLVVIIRMIVGLFWYGINTYNGALCIKAVILAIWPSFADVPNRLPRSANITTQVMTAYIIYFLCVLPFHYIHPRKLTWFFHAKAILCLPAIFGMLGWACQATGGGLHTSLLQRGTTISNSKYGWAFMSALNSMLGNYGTMAVNINDFARYSRKTRSVYIQILIIPLSFALMSFMGIIIAGAATDLYGEEIWDPLTVLSHWTGSGRARAGAAFCGLALALAQLGTNLSANCISAANDLNAMFPKYVNLRRGSYIVAFVGAWVLTPWNILASASALLNFMDGYTIWLAPITGILLSDYYLVHHQKYQVLELYDPQGRYRYNRFGTNWRAMVAFVASWVPLTPGFAHAVTSTNSIAMGALHLYYLSYLFGICTSAVIYTGLNWAFPHVGSVVSEGWTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M3B2W2</accession>
    <name>M3B2W2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Plus-3-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_131859</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762248.1">
        <property type="nucleotide sequence ID" value="XM_016902454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B2W2"/>
    <dbReference type="STRING" id="692275.M3B2W2"/>
    <dbReference type="GeneID" id="27899591"/>
    <dbReference type="eggNOG" id="KOG2402">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019525_0_0_1"/>
    <dbReference type="OMA" id="ISGCYAR"/>
    <dbReference type="OrthoDB" id="166375at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.200:FF:000005">
        <property type="entry name" value="Related to Pol II transcription elongation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.200">
        <property type="entry name" value="Plus-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004343">
        <property type="entry name" value="Plus-3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036128">
        <property type="entry name" value="Plus3-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03126">
        <property type="entry name" value="Plus-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00719">
        <property type="entry name" value="Plus3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159042">
        <property type="entry name" value="Plus3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51360">
        <property type="entry name" value="PLUS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plus3" evidence="3">
        <location>
            <begin position="254"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="161"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="455"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="541"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="416"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="95"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="181"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="551"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF14127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="605" mass="67684" checksum="9F67FBC310F32872" modified="2013-05-01" version="1">MADLDEELLGLVGDDDSGDEGSLDDLERPEQAELGDISGGEEPQPSVEQVDDVPERRKGVAQKVRAKRGKRKVRQQSEDEDDDRSATPGSPESVVQDDEADAPGEEEEEIEPLYPLEGKYKSEDDRHYVEGLSEIQREELLAQRAELVTRRTQDQLLKKALASSSAANKQKRKAAAADLEDNNRRTTRPKTEKQTALDTYRKAREEKGAQRDRIASARDRRDERSPSSHGSERDADGESEVEWAAEPERKDEPPAEITDFNYARMGRSGFAKVCFYPGFEEAIMGSFARVAIGPNRETGQSMYRMCQIKGFTEGKPYQMANSVGKPFTTDQYAIVAQGSAEKPWPFSACSDGRFTDAEYVRFMDTLRKESIKVPSRRFLHKKVAEIKGLLDMQFTEEMLNQKFSKQRAIQLKYDPVHQAKLKRKDIQRRRAEAEQNMDEEEMARCDAELEALENGAANGGPKTAPKVKAKDHASPAKPVAQHESLAILNRQNRAKNQHEVRQALIKERAKIEKARRDAHDKKTAEVRAAVHAKAHSRALQHNKELFGEDTPGTSRAGTPANGTNPPKKRADMGLNGVKGPIGALKKKNMDDEVISGLDLDIDIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>M3B2Y7</accession>
    <name>M3B2Y7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="14">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SEPMUDRAFT_147961</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="14">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11 14">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="14"/>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762278.1">
        <property type="nucleotide sequence ID" value="XM_016904622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B2Y7"/>
    <dbReference type="STRING" id="692275.M3B2Y7"/>
    <dbReference type="GeneID" id="27901759"/>
    <dbReference type="eggNOG" id="KOG0660">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="OMA" id="MDIPRPE"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000196">
        <property type="term" value="P:cell integrity MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902660">
        <property type="term" value="P:negative regulation of glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902413">
        <property type="term" value="P:negative regulation of mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905665">
        <property type="term" value="P:positive regulation of calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050850">
        <property type="term" value="P:positive regulation of calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032995">
        <property type="term" value="P:regulation of fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07857">
        <property type="entry name" value="STKc_MPK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000013">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000157">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="23"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="358"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="361"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="379"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="405"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047919"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048130"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00061056"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMF14157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="419" mass="47985" checksum="8DBFCA06D632DF35" modified="2013-05-01" version="1">MGDLNGRKTFKVFNQEFIVDERYTVTKELGQGAYGIVCAATNAQTGEGVAIKKITNVFSKKILAKRALREVKLLQHFRGHRNITCLYDLDIPRMDNFNECYLYEELMECDLAAIIRSGQPLTDAHFQSFIYQILCGLKYIHSANVLHRDLKPGNLLVNADCELKIADFGLARGFSIDPEENAGYMTEYVATRWYRAPEIMLSFQSYTKAIDVWSVGCILAELLGSKPFFKGRDYVDQLNQILHFLGTPSESTLSRIGSPRAQEYVRNLPYMQKIPFQTLFHRANPDALDLLDRMLAFDPSQRISVEDALEHRYLSIWHDASDEPACPTPFDFGFEVVDEVPEMRQMILDEVRRFRQSVRAPQYHSSQQAPPQQQVPIPEHYDPRAFEDPRPQELGQGPAAGGQQHDLERELQGLDQMRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M3B4G3</accession>
    <name>M3B4G3_SPHMS</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_40938</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OMA" id="WHERGIG"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF14697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="185" mass="20997" checksum="6028F23B81B263B2" modified="2013-05-01" version="1">MLRVVWRYACVAGQVPYDMRERMIRSLYKYSPMNAGVVNPSLVFKAWAAKFAIGVSRDLTPHTTGTLGDDERRLLELGCQHGLEKGSAESKARVHEMKRLVQDDLEEAGRCKPVHPLTDLLEQAWKKDLSWHERGIGRAASQIVPSSAEYGILETVMLDGTRVPMKSGDFTRFRKWEVPSRLRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M3B5R2</accession>
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        <recommendedName>
            <fullName evidence="5">Elongation factor-like 1</fullName>
        </recommendedName>
    </protein>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
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    </organism>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:GTP binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04096">
        <property type="entry name" value="eEF2_snRNP_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Elongation factor like GTPase 1"/>
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        <property type="entry name" value="Translation elongation factor 2"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1430.10">
        <property type="entry name" value="Yeast translation eEF2 (G' domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
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        <property type="entry name" value="EFL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF3">
        <property type="entry name" value="ELONGATION FACTOR-LIKE GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="17"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="508"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="771"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="513"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="771"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="791"/>
            <end position="801"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00081809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF15137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1095" mass="119856" checksum="7F084C1D69C5FC5E" modified="2013-05-01" version="1">MPVVQPEKLVKLQQAGDTIRNICILAHVDHGKTSLTDGLIATNGIISPKQAGKVRYLDSRPDEQERGITMESSAISLYFPLLQRSAPDTEPEQKEYLINLIDSPGHIDFSSEVSTASRLCDGAIVLVDAVEGVCSQTVTVLRQVWTEKLKPLLVINKMDRLITELKLSPGEAYTHLSKLLEQVNAVVGSFALGERMEDDLKWRERIDEKVSAAAAAKAQEDDGTWSRHSSIAQDDNGVVIGETSAEYEEKDDEDIYFEPEKNNVIFATAIDGWAFTPRQFAALYEKKLGIKRNMLEKVLWGDFYLDPKTKRVLLPKHLKGRNLKPMFVQLVLEQIWAVYEATTGGPNGKGDEALLEKITRGLGLKIPAHILRSKDPKALLSAIFSAWLPLSTAVLVSVIMSLPSPKAAQENRIPGLLEKSPGSSHIDQKIKDAMTQSDATIGKPVVAYVSKMISIPESELPSNKRRGGALTAEEARELGRKKRAEIARAQALASSEVGVDSVTDALSTAAIGDENELDDDAPAEDEEEKDDPEHLIGFARLLSGTLTVGDEVYVLPPKFTPAQPHAEPLPQKVTVTALYLLMGRGLESLNSVPAGNIVGIAGLEGAILKSGTIASQLEGAPNLSSTTAISTNAPIVRVALEPAFPGDLDKMIRGLQLLVQADPAVSYEQLESGEHVILTAGELHLERCMKDLQERFAKCEIQAGEAMVPYRESIVKAEEMKEPANPALGRGTIEGVTSSKQLTIRLSVRPLPTPVTEFLVKHTGAVKRLYSERKAQEEERSAGAKAGQAEESGEQEVEAEDTSAIADQGLSMSEFKQQLAEALLEEKADRELYKDAVHKIAAFGPRRVGPNILIDNTPDGICGRFFHDSIDHSSSGSNSTSSMAALADKIAYAFQLATYQGPLCHEPMQGVAIFLESVSTELSPDDISANMGRLTGEILRTVRDSIRAGFLDWSPRIMLAMYSCEIQASTEVLSKVYNVLGRRNGRIIDEQMLESTNNFTVLSLLPVAESFGFSDEIRQRTSGFAAPQLVFEGFEMIDEDPYWVPYTEEQLEDLGDKADKENVALRYVDKVRTRKGLAVKKKVVEAAEKQKTLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M3B6A5</accession>
    <name>M3B6A5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Urease accessory protein UreD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_79914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763453.1">
        <property type="nucleotide sequence ID" value="XM_016910231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B6A5"/>
    <dbReference type="GeneID" id="27907368"/>
    <dbReference type="eggNOG" id="ENOG502S9IJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053180_1_0_1"/>
    <dbReference type="OMA" id="TKHEKHL"/>
    <dbReference type="OrthoDB" id="5876637at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40644">
        <property type="entry name" value="UPF0653 PROTEIN C607.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40644:SF1">
        <property type="entry name" value="UPF0653 PROTEIN C607.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF15332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="337" mass="38126" checksum="1A66A6ABC6835B99" modified="2013-05-01" version="1">MPHKHKRKRENDKEHYDLPPSKIAKSLSTYEKTEKVQLKRGASRPKPKVNSKRKSDATSAYTSDDTPRAFARMMHLQQAGKRQRNGLDDGISKKPPKKKTAPRTTTTTTSTSSPSGNMETDADDIAEQKQVEDTASKLKIQPGERLSDFAARVNQALPLSGISQNRKKVPGGAKERQTKTEKRLHKMYAEWREMDQKRKAAEEEFLERQEQKDEELQNELGGQEIHLPAGAEGGKRSAKRKQKMLTELTTEKDDEDPWKVLEAKREKPKGLHDVVQAPPELKPVREKFKTKKMNGAKVDVDNVPGKSGSLARREELGQARKDVIERYRAMMKGKGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M3B786</accession>
    <name>M3B786_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CMD-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_114795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763838.1">
        <property type="nucleotide sequence ID" value="XM_016901113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B786"/>
    <dbReference type="STRING" id="692275.M3B786"/>
    <dbReference type="GeneID" id="27898250"/>
    <dbReference type="eggNOG" id="ENOG502S5XJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070025_3_2_1"/>
    <dbReference type="OrthoDB" id="104509at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052512">
        <property type="entry name" value="4CMD/NDH-1_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33570">
        <property type="entry name" value="4-CARBOXYMUCONOLACTONE DECARBOXYLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33570:SF2">
        <property type="entry name" value="CARBOXYMUCONOLACTONE DECARBOXYLASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxymuconolactone decarboxylase-like" evidence="2">
        <location>
            <begin position="49"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF15717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="166" mass="18670" checksum="6A4D9C125081D4E5" modified="2013-05-01" version="1">MPANYTPEEIQKAHEILYNEGIKMRYQVAGKEYVDKSLAAASNPFAQAMQDYVSESCWGSIWTRPGLPLKIRSFLNIAMLCNQNRSTELATHVKGALNNGASEEEIREVILQAACYCGMPAGIEGFRVAGRAVQEWHEQKLREGEMSRGDQDRHYDVDVASRSKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M3B8A5</accession>
    <name>M3B8A5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_115132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF16077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764198.1">
        <property type="nucleotide sequence ID" value="XM_016901132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B8A5"/>
    <dbReference type="GeneID" id="27898269"/>
    <dbReference type="HOGENOM" id="CLU_2759429_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032123" evidence="1">
        <location>
            <begin position="17"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF16077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="70" mass="7738" checksum="7A5BFB2339AB65F1" modified="2013-05-01" version="1">MQMITIVTLLLPLAMAAPTPISEPALQPMAEPIKRSPAAIEAVEAVEARSEAELDETDEQYKLYVYTTFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M3BP73</accession>
    <name>M3BP73_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_167066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="120"/>
        </location>
    </feature>
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        <location>
            <begin position="233"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="292"/>
            <end position="617"/>
        </location>
    </feature>
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        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
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            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
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            <begin position="108"/>
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        </location>
    </feature>
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            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
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            <begin position="317"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="405"/>
            <end position="421"/>
        </location>
    </feature>
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            <begin position="432"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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    </feature>
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            <begin position="592"/>
            <end position="608"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMF07958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="617" mass="66035" checksum="1F4B22F4EA4767A4" modified="2013-05-01" version="1">MATTEQYRPPGRSNRSGRSNVDNDVFEGLPVKQWGQTYAKVSLAPPVSEVEAGKDDKWGEPPMPRDYQLLNPWTQHLLRLARSGKVGNKRKQDAEADDEKAEDEAPEEESKQSGTDERGYIAKKWKPVPDHSLEPEHKHFSFLAKRRRGLPSLYGVDQQAVVVPMRKTKVQKADVNGEIAVYEVLVPEGQTIDGEIAESTELADVKPVTAAPGTFIEGVGVANEDGVMVAEHLKPSVAPRRNRPPPKKKGGPGRGKKRVTFTNPDGSTYTKIVPNATKIVPQPGQTIKHVAKGEEATADVSAVATVKDVQQQPGEGAEVEVEEGSGEDEEEGDDEDDDREDGELSDEDAPATASQTPAKPDPHGDSQPMEDVQPTSQPAPTEEADVPSATAAEPALTQEAGDSGEAVPEAAPETAPETAPEIAHENAPKTVAETSPTRTAESSPDLPLAQSHSRNASLAEPTSLSLDTVMTEAPEVAVAEEAEEAEGAKEATEPAEPTKPAEPVEVEEAKGPVEAKEPTDPAEPVEAKETQEPTESSEPENPAEESQEAQKEDSQKEETEIAASQETKLPPPPPSEEKEEENSSAPAAAAATEEEEEEKNPDEAEEDLLGNLEKSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M3BPB5</accession>
    <name>M3BPB5_SPHMS</name>
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        <recommendedName>
            <fullName evidence="4">Carbohydrate-binding-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_74673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456272">
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        <property type="nucleotide sequence ID" value="XM_016910075.1"/>
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    </dbReference>
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        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36578">
        <property type="entry name" value="CHROMOSOME 15, WHOLE GENOME SHOTGUN SEQUENCE"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004031927" description="Carbohydrate-binding-like protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF08008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="402" mass="42881" checksum="D24F9D941F3CC2B9" modified="2013-05-01" version="1">MLRRALLVPALVGLARSQPVASSDTYAPVAAPDALPIDDLRNVDVPTYTETPGLASAIVSYATETAIAAVQADVTQDPLSQFPAATDVPINSAGEDSSSNNKRGLVVRDACDAQPTIANFYNVNVDDPSAFKADHTISSVALAAPTPAGYFNNFKNAPGANSAYAYLGYSVVNDGKTGYDVNWCAEQCTSINGCLSFNIYFERDPIIEPGAGCENPHAFANIKCSFWGTALDSSTANNFGQWRSDFQVVIAGSNAYTSSKLGGPVHGYNPPQSLNTSTMNAPLRDCSNTWTYLGYKLLQSGPYDPSLCGAACDAQTAYNAAHPSSTDEEPVKCAAFGSYILSMTNATSTYQLGQMCTLYTSDWDAEKYAVNTVSYDDGIGAKYTYGYSFFYAKEELQPVCES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2022-12-14" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>M3BQJ3</accession>
    <name>M3BQJ3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_152074</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016907227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BQJ3"/>
    <dbReference type="GeneID" id="27904364"/>
    <dbReference type="HOGENOM" id="CLU_2559764_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF08393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="82" mass="9366" checksum="866A79BEB2A96A03" modified="2013-05-01" version="1">MGRKYGQRYIKYELIEHGYNAHGEGDAAERCARRRPKVISQSASRIVSNGSHRDIEDIYGLLSMTCHSRDHLGVMLREPSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M3BT06</accession>
    <name>M3BT06_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Heme haloperoxidase family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_143610</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF09800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016903050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BT06"/>
    <dbReference type="GeneID" id="27900187"/>
    <dbReference type="eggNOG" id="ENOG502S6CG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029871_3_2_1"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF1">
        <property type="entry name" value="HEME HALOPEROXIDASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032343" description="Heme haloperoxidase family profile domain-containing protein" evidence="8">
        <location>
            <begin position="24"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="9">
        <location>
            <begin position="95"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF09800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="460" mass="49617" checksum="CDB39B6826CD39B6" modified="2013-05-01" version="1">MKYYAAAPPLLLLLSSAPQLATAFPSSILSQAASQDPSFAARAAEILRSSSSSSSSNTFNSKRQQILTADGATKIFEPVGIFNAEAQLVDVGPGSGHEWIAPGPEDLRGPCPGLNAFANHGFLPHNGYATITQFIEATNSVVGMGVQLAAFLAVLGAGIDGDGISWSIHGTPPPGVGGPLSGFGNGLSGSHNKYESDASPTRPDLYQTGNNYKLIIDQFRQLISMSPNGIIDLNSLTAFRSQRFDDQISSNPFFFNGPFTGVLVQPAAYTFIYRFMANHSVESPHGELRSEVLQSWFGVEEEEGGGGEYVWREGWERIPLNWYKRPIEYPYDNAYFLADAANAAALHPKFLNIGGNTNGPNTFTGLNITSFTSGLFPAENFFTKKDSFACFAYQFAAQAKPDLLGALDVVTGQIPSLTSQVKALMGELEGCSQLRGVDEELLMQFQGYRRSKGEGIVKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M3BTY1</accession>
    <name>M3BTY1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_13804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758236.1">
        <property type="nucleotide sequence ID" value="XM_016902860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BTY1"/>
    <dbReference type="GeneID" id="27899997"/>
    <dbReference type="eggNOG" id="ENOG502S0T3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1113649_0_0_1"/>
    <dbReference type="OrthoDB" id="3641074at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004031435" evidence="1">
        <location>
            <begin position="18"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF10115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="250" mass="26801" checksum="95BCC07569C82676" modified="2013-05-01" version="1" fragment="single">MKAALTTLLLCVGAVSAIAVAEPVANADPKKKKKAQSGRKAYQGRFGFCGVAGSNCARMKRSAEAIADAFAEADPDARYQGRFGFCGVAGSNCHKARRAIEHIGELAERSYSEIETRSGRKAYQGRFGFCGVAGSNCKRDAEAEADPKKKKKAQSGRTAYQGRFGFCGVAGSNCAMVKRDARYQGRFGFCGVAGSNCKRDADVEAVANIARAIEEWDPTYLAEVCHSEGGECSALVKAHRAFKQIKRDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2022-12-14" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>M3BU89</accession>
    <name>M3BU89_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_135574</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758366.1">
        <property type="nucleotide sequence ID" value="XM_016902721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BU89"/>
    <dbReference type="GeneID" id="27899858"/>
    <dbReference type="HOGENOM" id="CLU_1723486_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF10245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="152" mass="16903" checksum="8C99A78631BE6B34" modified="2013-05-01" version="1">MAQRIFRVGGGLPPIAQFDCHTAKTARLQYNGYRTLSCIDHRASSPPPQTQQLLVSGLTLAAKSTSSSNLDRTELRIPLHDSAGSASTDNGTIRRNLNCEELLNSCRRVWWRHVTRPPTSHRAEGMTYKWNHEKSRDGIVFVGSERLAGGEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M3BWZ6</accession>
    <name>M3BWZ6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Amine oxidase</fullName>
            <ecNumber evidence="11">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_149210</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="11">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="10">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="10 11">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="11"/>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760697.1">
        <property type="nucleotide sequence ID" value="XM_016905414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BWZ6"/>
    <dbReference type="STRING" id="692275.M3BWZ6"/>
    <dbReference type="GeneID" id="27902551"/>
    <dbReference type="eggNOG" id="KOG1186">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011500_3_1_1"/>
    <dbReference type="OMA" id="LYAGGWY"/>
    <dbReference type="OrthoDB" id="5379943at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.20:FF:000001">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049948">
        <property type="entry name" value="Cu_Am_ox_TPQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF33">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01164">
        <property type="entry name" value="COPPER_AMINE_OXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 11" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="12">
        <location>
            <begin position="252"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="413"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="10">
        <location>
            <position position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF12576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="701" mass="78290" checksum="0FEDF6B8B56CB9FA" modified="2013-05-01" version="1">MATESVATQLPVRTSNHISVHPLAPINGTEIQNAVALVRAQWPADTDLHFKAVTLQEPVKAEMLPYLEAEFSGSTLPKIDRRVFLTYYLRRTNKFHEAVANLSTQTVEFNARLGANMHAPGDGEEIEAMERIALADEGVQAELAKLQLPKGSHVVVDPWIYGADGVDDDERMWQCFLYMRDPQNSGEVDSCHYAFPLTVSPVISSVSMKVIRIDIMPTGKDNSVKEPKIYKPVGANEYLPEYQKLRTDLKPLHVVQPEGASFTVEEQGTSNFIQWQKWQFRVGFNLREGMVIHDVRYEGRNLFYRLSLSDMNIPYADPRNPFHRKSAFDLGDAGAGIMANDLKLGCDCLGSIHYLSSTLNNDKGEPLDMPNVICIHEQDGGIGWKHTNYRTGRAAVVRNRELVLQSIITVANYEYIMAFMFNQAGELAYEVRATGILSTQPIDEGLEVPWGTVVHPGVLAAHHQHIFSLRVDPMIDGYHNRLVYDEALPMPRSADFNPHGTGYFAQETVVETSGGYDIDYAVNRTFKIQNVHKRNPVNGKPVAYKIHAPPFQKILADEDSFNHMRAEFSDHNIYAVSYRDDELYAGGKYTNQSRGGTGVRAWANRKDPIVDEDLVVFVQFGINHIPRIEDFPVMPCEVIKVALKPVNFFEKNPALDVPPSTQDFNQSVLLGNEEKAGVDACCISSGSGKSTTATTATTSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M3BXY2</accession>
    <name>M3BXY2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nitrilase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_86353</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761037.1">
        <property type="nucleotide sequence ID" value="XM_016910411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BXY2"/>
    <dbReference type="STRING" id="692275.M3BXY2"/>
    <dbReference type="GeneID" id="27907548"/>
    <dbReference type="eggNOG" id="KOG0805">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030130_6_2_1"/>
    <dbReference type="OMA" id="CVEPKQF"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07564">
        <property type="entry name" value="nitrilases_CHs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044149">
        <property type="entry name" value="Nitrilases_CHs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044:SF2">
        <property type="entry name" value="CN HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044">
        <property type="entry name" value="NITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="3">
        <location>
            <begin position="8"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="329"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="371"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF12916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="394" mass="43258" checksum="BE16E175E1EE9185" modified="2013-05-01" version="1">MAAWLPKVRVAACNVAPVFLDTAKTVQKTIGLIREAANNKADLVVFPETYIPAFPLWSAVSAPIDNHHFFSKLASQSLLINGKDMQALQQACAHSKVYAHIGFNERSPASVGCLWNASVLISDQGQILNHHRKLVPTFYEKLTWAPGDGAGLQVIDSPRIGKVGSLICGENTNPLARWALMAQGEQLHLSTWPAVWPTRRSKDISGESSKQYDNIAANRTRTAAHCFEAKCFGVLCSGFMDQEMRNSLVKHSPSAAETLDSLTQGASLFLDPTGAPVGEQIQGEEGVIYADLDLNQCVEPKQFHDVVGGYQRFDVFDLKVNTRRLGAEKALEREQRSQSVNDTAASSQQPQWSFSSLPRREIDSSTGTEAGLERLKAELEGMRNDAFQSTRDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M3BYX1</accession>
    <name>M3BYX1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RmlC-like cupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_155631</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761397.1">
        <property type="nucleotide sequence ID" value="XM_016907628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BYX1"/>
    <dbReference type="GeneID" id="27904765"/>
    <dbReference type="eggNOG" id="ENOG502S2RN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_702423_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02223">
        <property type="entry name" value="cupin_Bh2720-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052538">
        <property type="entry name" value="Flavonoid_dioxygenase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43346">
        <property type="entry name" value="LIGAND BINDING DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14370)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43346:SF1">
        <property type="entry name" value="QUERCETIN 2,3-DIOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="2">
        <location>
            <begin position="261"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF13276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="393" mass="41960" checksum="75B1D7AEE796C9FB" modified="2013-05-01" version="1">MELPRGADVFEVEIASTSGVHQRGPAKPTRGPQIEDLGWCKSCDALTALFSRNTTSGNSTLPFLDHPSFYLISLAMPYPAMQISGSSGNLQSRSLLTSSSQAPIALAYPIPTELQRSNQGTYDSDEMVASVAEAYGSSALETEASVRAFDVGIAFSGRCVVMGHCVPATGSQTGDFAMRVPSRHLLLATKPTLQLRTAAAAATAVLRPFSTAKATMGKDSQISKSPPKHELVYFPGLASEVRAFGQFRKVLHTGLYSQVVTMEIPVGGDIGDEVHTVDQVLLFTSGEGKATVAGKDQAVKASDVVVVPAGTQHQFINTSKDKPLELVTIYSPAEHDPQTVHKTKEEGDEEEDNGKDEAPGWSQQSKDHNEKKGVVKESGGPYENGDDGRHNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M3BZD8</accession>
    <name>M3BZD8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolase family 105 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_42515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761527.1">
        <property type="nucleotide sequence ID" value="XM_016908873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BZD8"/>
    <dbReference type="STRING" id="692275.M3BZD8"/>
    <dbReference type="GeneID" id="27906010"/>
    <dbReference type="eggNOG" id="ENOG502RXA5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038720_0_0_1"/>
    <dbReference type="OMA" id="RYSTWML"/>
    <dbReference type="OrthoDB" id="540611at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052043">
        <property type="entry name" value="PolySaccharide_Degr_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33886">
        <property type="entry name" value="UNSATURATED RHAMNOGALACTURONAN HYDROLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33886:SF11">
        <property type="entry name" value="WALL GLYCOSYL HYDROLASE YTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF13406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="383" mass="42227" checksum="31977869CB67435C" modified="2013-05-01" version="1">MLESNIGRGQGIAASNASTGQIELGLFQQALHESIAFTNNTDEKQKWQSLLETSITSANLSLSNATKNTELPLDRLSIGTAMLRLYDATKNEALIPTIKALQLSAINQKRNTNGGLWYYDNPLNQSAYHNLSYLDGMFSYSPFVILSTKLDFASDTNNLNEAAAWNQLSILRSITEREDGLFVHGYDPTQNHTWAQPSEKGASPVVWGRALAWYTLGVVNSIELLETQYSDLISNFKTLYRDLISAQLRAADRSLAIEGQYGVWQIVDRPGATFNGHANFIEASSSLMTAYSLLKGARLGWLEDDASLKLRAQIAGVGIFNDMRQRYMIVNDNSTLSLNGTSSVSTLSGNVDYEYYVTRPTVLNSLIGSSAFILAAMEAERLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M3BZS6</accession>
    <name>M3BZS6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_148810</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761682.1">
        <property type="nucleotide sequence ID" value="XM_016905163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BZS6"/>
    <dbReference type="GeneID" id="27902300"/>
    <dbReference type="eggNOG" id="ENOG502T560">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108566_0_0_1"/>
    <dbReference type="OMA" id="CERNSIR"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF4">
        <property type="entry name" value="HYPOTHETICAL CONSERVED PROTEIN (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF13561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="222" mass="24433" checksum="72311ADC2485E559" modified="2013-05-01" version="1">MPTATRELHYVNTKLPKLRTTYHIPVAMSSPSGVSASKQDSMSPAQSRELPMPVISRFTSIDQAHATLQHCATRLNNSWQGNPARSSPPSPPIDGNEKLFFQQWLARWESAFTAYLSVHMSSMSANDVTQSRTLKANHLSCTILASDAGPSKREYGIFTAEFQAIVELANAVISLRPPRSRSPAPVTSALDMCEPLYVVIACCDRMSTRNKAIELLGKINSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M3C3E7</accession>
    <name>M3C3E7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EGF domain-specific O-linked N-acetylglucosamine transferase</fullName>
            <ecNumber evidence="1">2.4.1.255</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Extracellular O-linked N-acetylglucosamine transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_83413</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:12251"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:90838"/>
            <dbReference type="EC" id="2.4.1.255"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48908"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:12252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:90840"/>
            <dbReference type="EC" id="2.4.1.255"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.4.1.255" evidence="1"/>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762922.1">
        <property type="nucleotide sequence ID" value="XM_016910334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C3E7"/>
    <dbReference type="STRING" id="692275.M3C3E7"/>
    <dbReference type="GeneID" id="27907471"/>
    <dbReference type="eggNOG" id="KOG4698">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030112_0_0_1"/>
    <dbReference type="OMA" id="VMRATIN"/>
    <dbReference type="OrthoDB" id="529273at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097363">
        <property type="term" value="F:protein O-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049625">
        <property type="entry name" value="Glyco_transf_61_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007657">
        <property type="entry name" value="Glycosyltransferase_61"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961:SF148">
        <property type="entry name" value="EGF DOMAIN-SPECIFIC O-LINKED N-ACETYLGLUCOSAMINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04577">
        <property type="entry name" value="Glyco_transf_61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase 61 catalytic" evidence="11">
        <location>
            <begin position="261"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF14801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="417" mass="47495" checksum="5C557766078B0583" modified="2013-05-01" version="1">MCAAAAASEDGSSSRPSFTCFTHNAWTYWRDRQEDTFCVGTQVVLDPESGAHVDCALRNLTEEKQLMKPHAQALDRIADNWYWTGTRYLLDRFMHFRRNGTESISVQLADDAVHVPERTVLLVKREGGNVINNVWHVFMQMMSLWLSLDVMRATINPATGQPFYTDEDVKNTQVMILDQDKEGHLYELWNMFGDLPTIRRADSPPLKSTRVVLPLAGGKNPIWQSRLELPNCNSSILLQAFVNRILNFYHIPLSPPPRPQNTSTTTTKAPLNLVFVDRKNYRLLTNQSHLLTSLHSHLTTTHPHVHLEIIDFASYPSFPSQILKLRSTDILLGVHGAGLTHTLFLPPKSTVVEIQPPGLRYFGFAALAKFLGHRYLQVYGEEREYEGMTHNWQADDVFLNEGEFLRLVDRAVEGWDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M3C426</accession>
    <name>M3C426_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_79218</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat LST8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763127.1">
        <property type="nucleotide sequence ID" value="XM_016910214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C426"/>
    <dbReference type="STRING" id="692275.M3C426"/>
    <dbReference type="GeneID" id="27907351"/>
    <dbReference type="eggNOG" id="ENOG502RZG9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_293409_0_0_1"/>
    <dbReference type="OMA" id="ATGCHSA"/>
    <dbReference type="OrthoDB" id="10248252at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037588">
        <property type="entry name" value="MLST8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842">
        <property type="entry name" value="G BETA-LIKE PROTEIN GBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842:SF0">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX SUBUNIT LST8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="609"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="44"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="170"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="756"/>
            <end position="838"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF15006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1036" mass="114417" checksum="E842CB6E8EAA9806" modified="2013-05-01" version="1">MARLPGRTLGAIKFRYYTQGRAREEPAAWSADASLSQPNAFEASAPLQQPTPPNLRETQRAAPTVKAPTAGVKMSSSQYTAADNALLKRLKEVDKLKWPDIHAYFPERSLGSLQVHYSTKVKAADLDLSKAPELHRTDSQDTVLVRSKRSRKSKVADGFISWADARSLMRDGPDIEDDREDMTRNAATPGPLDQQDSAFPQTVSRILRQREIGNITGARAWTATRCTLPDELKNTVCKDYTLQQYYHGTSGDVVGLSWSSTGKRFAAGSIAITDNRSMQYNMSRNLLVGDYEKTELQELVEHHVPRPLVEEADNPNALGAMRHTQDPRLFLTVTATGFSPAPGQEDYLFTAGTDKMLRRYLVGSDISHTRPEHAVEHAASVDLLAIHREGIIATGCHSASDSINVFRSGQAGLDNVWTGSPKRQDLQTTASIFPLSLKWGEAYVHRNFLLAGFSSDSNTSIEDQQLAGETALWDMVHQKQLEIKGTIRNVFDVCWNPRPSSSSVVFAVASSATGMDFSRRMRTAVSCFAPSQPLSAVVRWQCPALDINDVVICPYDNHLIAAGATDGKVYVWDQRWAGAGQSPLHVLSHDDSLNVLPHGYDKELTDTGVRFLSWGTTSSRLFSGSSDGVVKVWNPYRSADNAHVEDINVPRQHRSAIMSGTFSPDYRELLIGTENGRINVFKMGGAVRRPQQFKLHTASEPDSNPHHVLEAANAQIKSRAIAVRPCGAMPIKQAVQGEFYQGPFQAPTSRDCANAARNLQQALDAQADLAANLAQQGGIDCHDPALLEKAQSRVRDAQAAIEDLQSRADFAAQSRPRAEAFQHSLQQSRKERKDLLARAREVFANDAGPCKSDCAYLPTSDELEDNRRSELRIPGVLRSIGNEELTLARMHDSDQAAERCSKCFPLQAQRKGKGSQRELCLTCKLDRMRLTTVCSLCSSPARVETEPNKQPLCEACTFACFRCSGPVKFSRGARSLRCESCKLSWNAGVLGYELVTKAEKAPKVDAPQGHSMMPLYEQYDDLGALERERLAENWEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M3C496</accession>
    <name>M3C496_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_130852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763217.1">
        <property type="nucleotide sequence ID" value="XM_016902382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C496"/>
    <dbReference type="GeneID" id="27899519"/>
    <dbReference type="eggNOG" id="ENOG502RG8P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_877628_0_0_1"/>
    <dbReference type="OrthoDB" id="3650678at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF15096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="317" mass="34869" checksum="EDC4F9223409446C" modified="2013-05-01" version="1">MATIKSSIPRPDPKARSPVPYARRRRNSAPSTPATPHSYLPVPSATASCTASRSPRDSGIAFVLNRPQTPPSALPIRLEARTSRLACVSRVLLTPSSVASQTSHAEKELSPSARKLQTLTPRSSPYMSPHISDPCTTGSLVHHLHPCGHKVITRSPVPCASNCLREYNEKTLRWANAVITKEGFVCAACVQTHIQEHRSAQLRDLKDRFARTEARMGPLDREWLKQQIAYGRRVLENDIEKEVKEFGKLGRPCSMIPGEPLIVTEKDPIRKLNTVTRPRSSRPSPKGDRVPGTAVPKSLLYMPRTRSGAALHGGRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M3C4E9</accession>
    <name>M3C4E9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Maltose permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_59673</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763282.1">
        <property type="nucleotide sequence ID" value="XM_016909501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C4E9"/>
    <dbReference type="GeneID" id="27906638"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_11_5_1"/>
    <dbReference type="OMA" id="NCSIGPL"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000023">
        <property type="term" value="P:maltose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF5">
        <property type="entry name" value="ALPHA-GLUCOSIDES PERMEASE MPH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="151"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="402"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="474"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="50"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF15161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="537" mass="59656" checksum="07688EA80F57617F" modified="2013-05-01" version="1">MVSKGDDVATISDVDVEHTERLPDAAEANAQEHELTFWQGIKLYPKAVFWSLAMSTVIIMEGFDNKLLPTLYALPVFREQFGHMNSHKKYEISAPWQSGLGNGASIGQLAGLLIGGHLIERYGFRKMMLAGQTAIVGCIFIQFFAKSLPVLLVAQIVFGIPLGIFQASAVVYALELGPLCLRAYLTNYIHLCWALGQLLAVGSVRGLLKRGDEWSYRIPFAMQWMWPTLLIPLTYFAPESPWWHARRGQPAQAKANLKRLVSPKNTEFDFDKHVALMVLTTRHELEIESGTSYRTCFQGTNLRRTIIVMMIYCVQTLNGNPLRGFSTYFFQKAGLQTTQSFNMSIIQFAVAILGGITSWPLLPLAGRRTLYMTGLFLLLTIMASIGALGIPQAHNPKSDLSWGIGSLLVISSFIYYASVGPLTNTICVEIPSAMLRSKSIALARGAYIITTIIAGVLTPYQLNEDAWNWGAKTAFFWLGGCIISFTFSYFCLPETKDRTTAETDYLFEKKVSARNFAKTPVNFEAAITGVEGKDVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M3C4V3</accession>
    <name>M3C4V3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HSP20-like chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_147240</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763442.1">
        <property type="nucleotide sequence ID" value="XM_016904168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C4V3"/>
    <dbReference type="STRING" id="692275.M3C4V3"/>
    <dbReference type="GeneID" id="27901305"/>
    <dbReference type="eggNOG" id="KOG0710">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046737_0_0_1"/>
    <dbReference type="OMA" id="KSYVIHV"/>
    <dbReference type="OrthoDB" id="5511210at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031107">
        <property type="entry name" value="Small_HSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11527">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="5">
        <location>
            <begin position="185"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="57"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF15321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="305" mass="33198" checksum="B8EAD456B11155C7" modified="2013-05-01" version="1">MPSVHYYNQTGPFWDFVANLEQQGASRGAEASDNENEHEHERSNPWLQDWVGFPWGPMAHHGRHQRGPPPPHHHHHGHPSPPSPPAPPAEGEAGSSETKDPTQPFSDSESESQAHHGRHNHDHHGAGARGGRCGGGRGHGRPRGFSGRGGRRGTHGGTFGPFGPIAGIFHEQLFGNDNKKENKAAKSGDFTPEVDVFDTTDSFVIHTSLPGAKKEDVAVNWDAEKSELSIAGVMYRPGDEELLKTLALDERKVGAFDRKVRLGSRANPAQVDVDGITARLEDGVLRVEVPKLDAGYVEIKKVDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M3C777</accession>
    <name>M3C777_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_115159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF16111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764232.1">
        <property type="nucleotide sequence ID" value="XM_016901135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C777"/>
    <dbReference type="STRING" id="692275.M3C777"/>
    <dbReference type="GeneID" id="27898272"/>
    <dbReference type="eggNOG" id="ENOG502SSMU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1234789_0_0_1"/>
    <dbReference type="OMA" id="ICAKNRM"/>
    <dbReference type="OrthoDB" id="1925287at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF16111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="227" mass="24210" checksum="C4FEBD326C0E86B5" modified="2013-05-01" version="1">MAQPVLVRAYTSGKRNNQGVAAPRKPSDRDAAALPPISSYAFADILRSVDGSREFQLAIDGIAEICAKTRLSLADEYGAHLPPLGEITTTSASTPRPQPPRPGMRRVLTSVPEASSGSSEGSSRKSTIKRGSIFSFRKKHHTKQECSRPMRRIRISSTGRTISVGTTTAMAAEVILLPETRSRSSSEATVVGPVLPRPAARVPATSPAQSSLQRLLLPSRSRAVVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M3C9C0</accession>
    <name>M3C9C0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_166860</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756531.1">
        <property type="nucleotide sequence ID" value="XM_016908266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C9C0"/>
    <dbReference type="STRING" id="692275.M3C9C0"/>
    <dbReference type="GeneID" id="27905403"/>
    <dbReference type="eggNOG" id="KOG1176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_2_1"/>
    <dbReference type="OMA" id="PNSSFWY"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="27"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="452"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF08410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="566" mass="62987" checksum="A94E4DE1B820AD8D" modified="2013-05-01" version="1">MPTKSSFPDVTIPDVDIWGLMFDRKDRDFADDKVIYRSATNPARKYTYAEVKSAATQFGEGLCNLWDWQRGEVLNIYAPNDIDIGPIIFGVFFAGGIVSPANPGYSADELGFQLKNSESKAIVTTKAFLAAATEAAQVAGIAQDRIILLGEEKDQTYRFKHWTSIRKTSGAQRYRRRKAKDPRKDLAFLVYSSGTTGLPKGVMLSHSNIVSNLTQIQNSIGPSYQSSQDKILGVLPFFHIYGLTGLVHQPLHRGIELIVMPAFDLQLFLTTIQTHKITFIYVAPPIIVRLARDKIVSQYNLRSIKMMTSGAAPLTKELVEAVYKKFGIRINQAYGLSETSPMTHTQPWKEWNTSMGSVGKMFPNMLARYVSAEGNKELGPGEVGELWLAGPNIFQGYWKNEAATREAVEVIDGHRWFKTGDVGFQDSAHNFYITDRVKELIKYKGFQVAPAELEGKLMDHPLVNDVAVIGVEDPEQHTEVPRAYIVHAKLGKEAGDVKTGVPKGDDARKDAQEIIDWTAGKVANHKRLRGGIRFVDEIPKSASGKILRRVLKERVKADAAASRSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M3C9M7</accession>
    <name>M3C9M7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CRM1_C-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_128862</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the exportin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756656.1">
        <property type="nucleotide sequence ID" value="XM_016902239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C9M7"/>
    <dbReference type="STRING" id="692275.M3C9M7"/>
    <dbReference type="GeneID" id="27899376"/>
    <dbReference type="eggNOG" id="KOG2020">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011906_0_0_1"/>
    <dbReference type="OMA" id="WAFKHNN"/>
    <dbReference type="OrthoDB" id="27218at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030621">
        <property type="term" value="F:U4 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071528">
        <property type="term" value="P:tRNA re-export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000490">
        <property type="entry name" value="CRM1p Major karyopherin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041123">
        <property type="entry name" value="CRM1_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041235">
        <property type="entry name" value="Exp1_repeat_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045065">
        <property type="entry name" value="XPO1/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014877">
        <property type="entry name" value="XPO1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040485">
        <property type="entry name" value="XPO1_repeat_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223">
        <property type="entry name" value="EXPORTIN 1/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223:SF2">
        <property type="entry name" value="EXPORTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08767">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18777">
        <property type="entry name" value="CRM1_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18784">
        <property type="entry name" value="CRM1_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18787">
        <property type="entry name" value="CRM1_repeat_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01102">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="8">
        <location>
            <begin position="25"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF08535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1073" mass="123252" checksum="743B2836095F5E29" modified="2013-05-01" version="1">MATIEELDATVRAFYEGRGEQQKAAQASLNQFKENPDAWLMVDQILEKAQYPQTKYLGLQVLDSVIMTRWKVLPRDQCMGIRNFVVNVIIQQSSTDESLKKERALLNKLNLTLVSILKQEWPHNWPTFINEIVTSCRASLPICENNMAILRLLSEEVFDFSAEQMTSTKTRQLKQSMCDEFTSIYQLCSEILRTADQPSLIKATLETLLRFLNWIPLGYIFETPPTGMSLIELLRSRFLEVPEFRNITLKCLTEIGSLQTEHNWDEKLVEMFTETLTTISTIIPLSLDLKSTYSASNSRDQEFVQNLALFLCNFFSNHLGLIEALPNRDFLMHGHFYLIRISQIDDREIFKICLEYWTKLVCELYDEMQQIPITDMNPLINMSGMANGGGAMNPQIMANYPLRKHKYIDVLSNLRQVMIEKMVRPEEVLIVENDEGEIVREFVKESDTIQLYKTTRECLVFLTHLDVVDTEQIMSEKLARQVDSTEWSWANCNTLCWAIGSISGAMNEETEKRFLVTVIKDLLGLTEMKRGKDNKAVVASNIMYIVGQYPRFLKAHWKFLKTVVNKLFEFMHETHEGVQDMACDTFIKIANKCKRHFVIQQPGESEPFIDEIVKTMRKITCDLSPQQVHTFYEACGYMISAQGHKNTQERLIAELMSLPNSAWDQIIQSAHQDPSILQNGETIKVVGNIMKTNVAACSSIGSYFYPQIGRIYMDMLTMYRASSQLIDESVQRDGNIATKMPKVRGLRTIKKEILKLITTYVEKADDLEMVHSTLVPQLLEAILLDYKNNVPDAREAEVLAVITVLITKLQGMMTAQVPAILDNCFECTLDMINKDFSEYPEHRVEFFKLLRAINQRCFPALIKLDQTHFKLVIDSCMWASKHDNRAVEGEGLNMCIELVENMANHTDQQTCDAFFQSFYTTILQDVFFVLTDSDHKAGFKYQSMLLARLFWLVGANKISSPIYTAEQATAGTSNRDFLQNFVATLLSNAFPNLQGQQITNFIRQLFESTEDLPKFKLILRDFLIQLKEFAGDNAELFTEDREKAMRDAKEAERERMAKVGGLLKPSELDEDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M3CA37</accession>
    <name>M3CA37_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_120632</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756846.1">
        <property type="nucleotide sequence ID" value="XM_016901621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CA37"/>
    <dbReference type="GeneID" id="27898758"/>
    <dbReference type="HOGENOM" id="CLU_683639_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="133"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="296"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF08725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="403" mass="43242" checksum="9BB9A085959891F6" modified="2013-05-01" version="1">MPDQQAGLDIRASCAQTPRGFSAISPLCSIVCSNLTPARYESFAHPSHQLCLTWITSPSLVEKCAGSTSMVLADTESAAATCMSHSRHTSLLTTLAARTNTDYRDLLDSRLGKTPPNMQTSWHPAHMPPAFPRALTPTGPASLPPGPSRLPPREKAAAPRPFARPGGQPLYGTMPAPNVQTARLPAHMLPTFPHGLRPTEPASLPPPNQQVCRRYLGGYCQNSQLCGYSHDVQTTRIPPTIASRGRPAGRAQTQRRSTVQLERPHVEAVFSPEQQLPTPFAPRMDSDEMPVLRLRARSTGPGTESVFKLAQVPDRATKQTAGEAVPRSKDGPSSEGAEDLSARQGGVVAADRDGDVAEIGPEPGAKIDSERESDQGVQMPRDATLSLRDRLKQLKFGDGGGPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M3CAY8</accession>
    <name>M3CAY8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_151862</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757111.1">
        <property type="nucleotide sequence ID" value="XM_016907088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CAY8"/>
    <dbReference type="GeneID" id="27904225"/>
    <dbReference type="eggNOG" id="ENOG502SYKH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_169797_1_1_1"/>
    <dbReference type="OMA" id="QGQREDY"/>
    <dbReference type="OrthoDB" id="3050608at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF08990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="72" mass="7920" checksum="0AA6177CC44AE577" modified="2013-05-01" version="1">MNNNNMNTGNPAGGKEDYLDKAVDAVEKKLGGMSGKNVDPQKYRAQNEKLTDKIRGFLEKATGKKMPSKFSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M3CCR9</accession>
    <name>M3CCR9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase family 79 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_91359</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758328.1">
        <property type="nucleotide sequence ID" value="XM_016910553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CCR9"/>
    <dbReference type="GeneID" id="27907690"/>
    <dbReference type="eggNOG" id="ENOG502QW09">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022148_0_0_1"/>
    <dbReference type="OMA" id="TWEYGNE"/>
    <dbReference type="OrthoDB" id="2831684at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052974">
        <property type="entry name" value="GH79_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031728">
        <property type="entry name" value="GlcAase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183:SF2">
        <property type="entry name" value="BETA-GLUCURONIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16862">
        <property type="entry name" value="Glyco_hydro_79C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004031899" evidence="1">
        <location>
            <begin position="18"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-glucuronidase C-terminal" evidence="2">
        <location>
            <begin position="420"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF10207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="530" mass="57830" checksum="AD36015BD01102B4" modified="2013-05-01" version="1" fragment="single">MKLLPALSPMTLMAVLARSTDIITTIPSAPPLHANTPLDQFLSYSIEFSSFVDYAGNLSHPNTYSDTLLENIAHYAGRKPLVRVGGNTQDLTIFNSSQKQAVEQQFSASNPDYPANQTIGPAFFESYLTWPGVLFSHGFNLAATAPEHQQAVLDSVYYACRTLRDKLYAWELGNEPDFYAVKALNPTPPRQTGYTEAQYVAEWLALSQRMRRHMQTSCPDLAQHQHPRFWGPSLAGNPALSNFSAPKVFSAGYNSEESISMISQHKYIAARGDAGLSLQGTLMNHTNNKRAVSELLAVSASIQAISNETLRPQNAAFILGEGNSLARQGIGGVSNSFGAALWGFDYALTLVANGIGRWHVHQGTNYRYQAWQPVETRNTTKGTKAPYYGNIAAAAFLGDLSTKHRPQIADLGLPGSDQSAFALYTRGRLSKIALLNLRAWNATSDSAARPTESYTFQLPRGYRQASLQRLSANGSDAITGVTFDGFSYAAELDSGRPVRLQNVTCDEHVAVRNGRVTVTLPLSSAVILNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M3CD96</accession>
    <name>M3CD96_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AP-2 complex subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_150062</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <location evidence="1">Coated pit</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759152.1">
        <property type="nucleotide sequence ID" value="XM_016905943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CD96"/>
    <dbReference type="STRING" id="692275.M3CD96"/>
    <dbReference type="GeneID" id="27903080"/>
    <dbReference type="eggNOG" id="KOG1077">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003824_1_0_1"/>
    <dbReference type="OMA" id="PVLMHRY"/>
    <dbReference type="OrthoDB" id="28053at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030122">
        <property type="term" value="C:AP-2 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000020">
        <property type="entry name" value="AP-2 complex subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017104">
        <property type="entry name" value="AP2_complex_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003164">
        <property type="entry name" value="Clathrin_a-adaptin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02296">
        <property type="entry name" value="Alpha_adaptin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037091">
        <property type="entry name" value="AP2_complex_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55711">
        <property type="entry name" value="Subdomain of clathrin and coatomer appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0168">Coated pit</keyword>
    <keyword evidence="3 7" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin adaptor alpha/beta/gamma-adaptin appendage Ig-like subdomain" evidence="9">
        <location>
            <begin position="715"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="23"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="68"/>
            <end position="72"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR037091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037091-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF11031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="950" mass="106332" checksum="6EB6102B0B91CA2C" modified="2013-05-01" version="1">MAAAVSGMFNRGMGPSSKDNTMRGLVSFIADLRNARARELEEKRINKELANIRQKFKGGNLSGYDKKKYVCKLLYIYILGWNVDFGHLEAVNLISATKYSEKQIGYLAVTLFLYEGHELLHLVVNSIRKDLADHNELNNCLALHAIANVGGKEMGEALCVEVHRLLISPASKPFVKKKAALTLLRLYRKVPTIVQPEWAERIIAIMDDPDLGVALSVTSLVMTLAQDDPESYKGSYVKAAQRLRKLVVEQDYAGDYVYYKVPCPWLQVKLLRLLQYFPPSEDSHVRQLMRESLQVVLDNAMESPKNVQQNNAQNAVLFEAINLIIHLDTERDLMVQISTKLGKFIGSRETNVRYLGLEAMTHLSVRAENLDPIKKHQDIIIGSLRDRDITVRRQGLDLLYSMCDSTNSQKIVHELLKYLQSADYAIREEMVLKIAILTEKYATDVKWYVDISMRLIAMAGDHVSDEVWQRIIQIVTNNDELQVYAAQNILQYCKADHCHETLVKIGSYILGEFGHLIADTKSCSPIEQFLALQAKFGSCSPVTRAMILSAFFKFVNLFPEIRPQLLSAFRTYSHSLDSELQQRACEYLTISTMPSDDLLRTICDEMPAFPERASALLSRLDKKSSAAGDKRTWAITGKDAAPGLDRSATLKRNFSNSAVTTLNGANGTTNGANGAYKNGAVKTPIDELAGLDLTSGSTNLASAAHLSPGWEEGYNRLLMRSEGLLYEDAQLQVGCRTEYRAEVGCVILYFTNKSPAPMQSFTTTIDNPSTEQLKTETKNLPETKVHTGEQTSQMIIFTAHGVFTESPTIRVSYMAGSLQAVTLKLPVALHKYMDAAVLSSDDFFKRWKQIGGAPRESQKIFKAYDISTDSTKRSLTGLKWGVLDGVDPNTKNFVGATVLHTAGGKFGCLLRLEPNHENKMYRLTIRATDEAVPPVLMKMMEERLREPFPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>M3CDZ0</accession>
    <name>M3CDZ0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Alpha-aminoadipate reductase</fullName>
            <ecNumber evidence="6">1.2.1.31</ecNumber>
            <ecNumber evidence="5">1.2.1.95</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">L-aminoadipate-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">SEPMUDRAFT_88631</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the activation of alpha-aminoadipate by ATP-dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH. The activated alpha-aminoadipate is bound to the phosphopantheinyl group of the enzyme itself before it is reduced to (S)-2-amino-6-oxohexanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(S)-2-amino-6-oxohexanoate + AMP + diphosphate + NADP(+) = L-2-aminoadipate + ATP + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46936"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="1.2.1.95"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(S)-2-amino-6-oxohexanoate + NAD(+) + H2O = L-2-aminoadipate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12308"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="EC" id="1.2.1.31"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(S)-2-amino-6-oxohexanoate + NADP(+) + H2O = L-2-aminoadipate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12304"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="EC" id="1.2.1.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.31" evidence="6"/>
    <dbReference type="EC" id="1.2.1.95" evidence="5"/>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759367.1">
        <property type="nucleotide sequence ID" value="XM_016910479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CDZ0"/>
    <dbReference type="STRING" id="692275.M3CDZ0"/>
    <dbReference type="GeneID" id="27907616"/>
    <dbReference type="eggNOG" id="KOG1178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_19_1_1"/>
    <dbReference type="OMA" id="ENDKFTM"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00032"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004043">
        <property type="term" value="F:L-aminoadipate-semialdehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05235">
        <property type="entry name" value="SDR_e1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014397">
        <property type="entry name" value="Lys2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010080">
        <property type="entry name" value="Thioester_reductase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03443">
        <property type="entry name" value="alpha_am_amid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01746">
        <property type="entry name" value="Thioester-redct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845">
        <property type="entry name" value="CARRIER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845:SF1">
        <property type="entry name" value="L-2-AMINOADIPATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001617">
        <property type="entry name" value="Alpha-AR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="19">
        <location>
            <begin position="650"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="931"/>
            <end position="954"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EMF11246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1190" mass="131783" checksum="5380DF03A5673328" modified="2013-05-01" version="1">MPADQKDVRPDPTSDLHWSDYRGAIHEIFAANAKQHPERSCVIETASSTSPERVFSYKTINESSNVLAHHLVSNGIQRGEVVMVYAYRGVDLVVAVMGVLKAGATFSVIDPAYPADRQNIYLEVAQPRALVCIEKAKQEAGELAPLVRNYISTNLNLRTEVPGLMLHDDGSVTGGSLQGGEDCLQAQQALKEELPGVLVGPDSTPTLSFTSGSEGRPKGVKGRHFSLAYYFPWMSKRFNLTDKERFSMLSGIAHDPIQRDIFTPLFLGASLIVPPAEDITFDRLANWASTNEISVMHLTPAMGQILLGSLEPKITSLHGAFFVGDILLKRDCRRLQQLAPNCRIKNMYGTTETQRAVSFYEIPSANEDSSYLDKMGDVIPAGTGMMDVQLLVVDREKKERQCEVGEIGEIYVRAGGLAEEYLGDPEKNSQKFVSNWFVDPKKWLEEDQKRVEAAGQPEPWREHYKGPRDRMYRSGDLGRYMQDGNVECVGRADDQVKIRGFRIELGEIDTHLSQHPLIRENVTLVRRDHQEEQILVSYYVPDMVKWREWYAEQEEAAGKQPITNGGLRPRRRESAKETHGIAQRMKIFDLLTQDARQRLKQKLPTYAVPTLFIPMLRLPLNPNGKVDKRALPFPERADLLGSLPEATDLEKRTDTEKELAKIWAEHLKTRNHTSETLPRDTSFYDLGGDSIMTVQIVPKINRKWQGINVPMSIMASGQPTLEKVAKYIDRSINPTSLRLDAAEDDEEVEQTLHYANDLPNQISQLPQTISGGPMRSAEKGVNIFLTGATGFLGAYVLSDALMRNTPNHVYAHVRAPSQAEGLERIRRTCTAYGLWQDSWATEGKLEVVIGDLEKPKLGLSDADYKKVAEEADLVIHNGARVHWLMPYESLRAANVTSTIEAIKLCASGKSKRLTFISSTSAVDTEHYVQQSDAGQPILESDPLEGSRQGLGTGYGQSKWVSEQIIREAGTRGLNAVIVRSGYVMGDPKTGVSNTDDFLVRMLKGCVQVGARPDMENTINMVPVTRVARLITAASFHGEPGSVAFVDAHPRPTFNEYLGALEKYGYDSPVESYSTWARKIEAYVEAGHEGPDELALLGLYHMVTGDLPAATKAPNVDDRKAQAALRADATVGGIETPATVTPEATGAYLSFLVARDFMAAPTKKEATPLPQIELSKMQVEALNRVGGRGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M3CFD0</accession>
    <name>M3CFD0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Flavin reductase like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_163650</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the flavoredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760649.1">
        <property type="nucleotide sequence ID" value="XM_016908073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CFD0"/>
    <dbReference type="STRING" id="692275.M3CFD0"/>
    <dbReference type="GeneID" id="27905210"/>
    <dbReference type="eggNOG" id="ENOG502QT1K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059021_3_0_1"/>
    <dbReference type="OrthoDB" id="10250990at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33798:SF5">
        <property type="entry name" value="FLAVIN REDUCTASE LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33798">
        <property type="entry name" value="FLAVOPROTEIN OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin reductase like" evidence="6">
        <location>
            <begin position="97"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF12528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="306" mass="33652" checksum="E8358A3F0E44BED2" modified="2013-05-01" version="1">MASSSTPAPSTQGTGQVDKKARNPRDFKPTENSRPDWNSSTPFTWTKTKNPNWKLGQGAVFSNNENSSSTSQPPQQIPIDPFAPNRNPAFNYRLITSAIIPRPIALLSTLSPDGSTSNLAPYSYFQAMSHDPPTFIIGHAVNPSSNKDSLKNILSTKECVINILTEDILEAGNASALDTPYGISEWPLTGLTPASCSLVAPSRILEAVFAVECKLVGTHEIQSREHEGKISNVMTILEGVKFWVREDVVDEDLKYIDPAKSRPIGRCQGITYARVMEAFQIPWPIWEDVREEAEREGLVRGKAVGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M3CH30</accession>
    <name>M3CH30_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">cAMP-dependent protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SEPMUDRAFT_148505</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="1"/>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761244.1">
        <property type="nucleotide sequence ID" value="XM_016904963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CH30"/>
    <dbReference type="STRING" id="692275.M3CH30"/>
    <dbReference type="GeneID" id="27902100"/>
    <dbReference type="eggNOG" id="KOG0616">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_5_1"/>
    <dbReference type="OMA" id="CFDDYPE"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd05580">
        <property type="entry name" value="STKc_PKA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF37">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="74"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="337"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMF13123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="394" mass="45161" checksum="B51BC678B306B074" modified="2013-05-01" version="1">MANGVVHNITSRFHRHSTSSAAGAKDNAADHENEKRKLAEWEADKRPLEPDEIVVDPQNKPVGHSSKHLRREDFDLVKTLGTGTFARVWMVKLAGRKDDSRNKVFALKILRKADVIRLKQVEHVRNERNVLAGVAGHPFITTMVASFQDSECLYMVLEYCPGGEVFSYLRRARRFNETTSQFYAAEIVLILEFLHEREGVAYRDLKPENILIDADGHLQLVDFGFAKKIHDRETYTLCGTPEYLAPEVIRNTGHGTAVDWWAFGILIYEFLVGQPPFWDQNPMKIYEQIVEGKVRYPSAMGKDARDIIAGLCTVDVTKRLGNMAGGAATVKEHPWFSNINWDDLYHRRMKGPIIPHLKGPDDTRNFDEYDPEPAEKQPYTKDMYEKYDKMFADF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M3CIE5</accession>
    <name>M3CIE5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MFS monosaccharide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_148841</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761714.1">
        <property type="nucleotide sequence ID" value="XM_016905181.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="27902318"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_3_1"/>
    <dbReference type="OMA" id="VAFANIQ"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="378"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="415"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="445"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="17"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="516"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="528"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="547"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF13593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="578" mass="63868" checksum="0FB79CF1B1E49B4F" modified="2013-05-01" version="1">MGKPFYGLRGTQLNIAIAVVAGVDFALFGYDQGVMGGLLTLPSFLKYFPEIDTANPGRTGRTASEVSNIQGITVGAYTLGCFFGAVATIWLGNILGRKKTIMVGSIIMIIGAVLQASSFELGQLIASRWLTGFGNGMNTSTVPTWQSETSKSHRRGQMVMIEGSLIVFGVMLSYWIDLGFSFLEPSTISWRFPIAFQIILALFIVALIPGLPESPRWLVLKGRDAEAIQVLSALDNTTEDDPKVQQEFRAVKDTVFEMARGSFTDCFKFNRNRNFHRTLLGYVNQTFQQISGINIITYYAATIFEQSIGLSPFLSRLLAALNGTEYFLASLIAIFTIERVGRRKLMLFGAIGQACSMAVLAGTTSIPNTDPRHVSAGIAAAVFLFVFNSFFAVGWLGMTWLYPAEITPLDIRAPANAIATTANWIFNFMVVMVTPVAFANIQYNTYTVFAIINAFMVPCVYFFFPETAYRSLEEMDEIFHKVHGWQGAFTVVKVAREKPRRYGKRGELLIPYEDTEEAREVEHRRRSSVVSSTTTTRPQQLLRSKGGGRDGGEESAAEKVEHVRNSSSGGEEEKKSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M3CIS3</accession>
    <name>M3CIS3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF423-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_148921</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016905229.1"/>
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    <dbReference type="eggNOG" id="KOG3472">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="269173at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="DUF423"/>
    </dbReference>
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        <property type="entry name" value="TRANSMEMBRANE PROTEIN 256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43461:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04241">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF13708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="123" mass="12779" checksum="843DFFFDE0C1BE53" modified="2013-05-01" version="1">MSTPWWIVGALSGASSVAFGAFGAHGLKSRGIAPEKIASWQTAAHYQLIHSVALLIAEQAAPKNVWAKGLFTAGIIGFSGSIYALVLNKDLKFLGPVTPIGGLCLMGGWLALAFGSRGRVILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M3CMM8</accession>
    <name>M3CMM8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_147045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763184.1">
        <property type="nucleotide sequence ID" value="XM_016904050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CMM8"/>
    <dbReference type="GeneID" id="27901187"/>
    <dbReference type="HOGENOM" id="CLU_1448568_0_0_1"/>
    <dbReference type="OrthoDB" id="3643152at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF15063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="187" mass="20389" checksum="28C1C30483701753" modified="2013-05-01" version="1">MSFKREESGDSGIEVSDPLRLTSNTPSAHGPITAAKPALERHISHIPTESDDEEVDDSNHQSGMKKLKNRIAHPHDKTKSKDDTTSSSSDYTEKRHDSGNATTSDFEISPGINLSDHIDSAEVKAKTPSLERHVSSIGEDGLLNPDAPPQQQQQSGSLSSSLGAHSPKLERQISDIPQHDYDSDREM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M3CNZ9</accession>
    <name>M3CNZ9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">N1221-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_147373</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016904256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CNZ9"/>
    <dbReference type="STRING" id="692275.M3CNZ9"/>
    <dbReference type="GeneID" id="27901393"/>
    <dbReference type="eggNOG" id="KOG3680">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003184_0_0_1"/>
    <dbReference type="OMA" id="KMTRAMR"/>
    <dbReference type="OrthoDB" id="18234at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040185">
        <property type="entry name" value="Far11/STRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021819">
        <property type="entry name" value="Far11/STRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012486">
        <property type="entry name" value="Far11/STRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13239:SF4">
        <property type="entry name" value="AT25231P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13239">
        <property type="entry name" value="PROTEIN REQUIRED FOR HYPHAL ANASTOMOSIS HAM-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11882">
        <property type="entry name" value="DUF3402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07923">
        <property type="entry name" value="N1221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01293">
        <property type="entry name" value="DUF3402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01292">
        <property type="entry name" value="N1221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Far11/STRP N-terminal" evidence="2">
        <location>
            <begin position="155"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Far11/STRP C-terminal" evidence="3">
        <location>
            <begin position="581"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="636"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="818"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF15503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1071" mass="119272" checksum="C928162AD8E77993" modified="2013-05-01" version="1">MDEVENPDLPKAGEASPTLRPIASGGEDANDAIGASITVAAAAAGGGGGGGGGAIVAPEEAVEQEIVLDSIEPAAKPALPASRAAVPVPARPPLVRPASNPPPSQPPPAPPGQDSGPPDFTQEPPDSLTLADLKRIRSTFPNAQVPQKQQLLGDDKVYDFDYQDAQSFPVELEEWFSYNDEEEVKLRKCQKVFHDEWRTTDEGKLDWLDVTEDARRLFIKKWITSLQEKHATQETITKALMILTYVGLGIWEETAGRQEGCALDDLFTNGKMGGSKLEEFGSSSLQVQWIVAMIDTLHSSDGLRVIYDTLRRVCDRDFEKSAPEMSSRNESQARRGDESMDLWCCLTLMYLFVEVSRTTGNAQALKTDVVALEPSFLNYLTQIIARLRWDEYAPIPLTKMLLLAWKTILISLGGIIEVEKVKTSLRGTSGEEKDTRGQPLITASPLDYHLFRQEISSKYPAYHPPPPLFPLEPENNSILPPLKHRRPSYVTVSDAAFAGAPAVGTGSIMHQPVHIATPAPSPPPSPAGPGKAGKKQNYQTNQMFPFLYPPLDASSNDLGGKGSTELQDALVGRRWEGADIPTSILEAAELFAKRMRATRAMKQLWEARVDFMKQERGWKKLNDASDNLDVDDFELVPKPEPDQTAEQGKPVAQTEEQRRLSKVNDYYRDSLPHLQSVVIVLLKAVLQNVTDLVTKGNGQNGLQAGIQFNETNSVNGTKPVENGVHSDGIESTMEELDKQRSQEIAAKALSAILLLLLKWFKVSHILQYEYMTQLLLDSNYIPLILKLWQTQEIGRACHFELDREDRNFFYFCQKSSRQGAPAARPDKDSSEESDDDAAPPPIKLKREETPPEQIPSPTTSPPDFTHPPEIDELGYPQTPLPPSPLKHYSYRNVFSAINYLRVLQKVTRRKTHRALLLVSYKSSNHLKKTLKIPIQMLRYYTLKLFKSQVPFCGRKWRQGNMKIITAVWLSVPAELRDDWLSGGGGGMGGACVGDVDGTVEDALPLEQSLRALTHWWNVRMFPDVMGVEKGMLDEEQDYFARELEKMELVREEELAEEPVLEEPWQGPIEGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M3CQ16</accession>
    <name>M3CQ16_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">6-hydroxy-D-nicotine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_161920</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763934.1">
        <property type="nucleotide sequence ID" value="XM_016907967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CQ16"/>
    <dbReference type="STRING" id="692275.M3CQ16"/>
    <dbReference type="GeneID" id="27905104"/>
    <dbReference type="eggNOG" id="ENOG502SHJ6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018354_0_1_1"/>
    <dbReference type="OMA" id="TWDLEYT"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF9">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="36"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF15813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="470" mass="53361" checksum="CF71EF39ECCBF331" modified="2013-05-01" version="1">MELADELSRRLSSEARVAASGTEDFAYSDLRYTQYGRPTYMAAVVPATQDDVVAVVQFCRERKIAFAARSGHHCVTTSMRHVRDGILIDMRSFSKCSHDVGGGVITNDFVRFLQDHEREVTIGSCPTTGVIGVAFGAGLGRLQGKYGYLHDNLLSCRLVLADGSVVDVTDHSHPLLFWALRGAGHNFGICLQATFRVYPEANRGRHCSWDLEYHLDQCDAVFATINEVHADMPADLAIFVLWRREHPTVGLKNLILVNLVWSGAEDEAHVWIERFERLQPAVRAGPLTTSWYDLPWETYGGMNKRLSKPEVWKLLPYKMMSAASVRSFDLPMIKAFFESVKEMNEKWEGKGWFGAMFECLPNQQTRALPSDATAFPWRGTDHFLMMTATPKSLDDRVPFEAHLDAWKENFVQVSGYGQLRQYVNYGSTTSTVQDPPESLYGYEPWRLQRLRALKQRYDPDGAFSWYQPFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M3CWN3</accession>
    <name>M3CWN3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">propanoyl-CoA C-acyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.176</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Propanoyl-CoA C-acyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_152178</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.1.176" evidence="2"/>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756663.1">
        <property type="nucleotide sequence ID" value="XM_016907286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CWN3"/>
    <dbReference type="STRING" id="692275.M3CWN3"/>
    <dbReference type="GeneID" id="27904423"/>
    <dbReference type="eggNOG" id="KOG1406">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035425_0_1_1"/>
    <dbReference type="OMA" id="PSLYAMM"/>
    <dbReference type="OrthoDB" id="542135at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00829">
        <property type="entry name" value="SCP-x_thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000016">
        <property type="entry name" value="Non-specific lipid-transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055140">
        <property type="entry name" value="Thiolase_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006102">
        <property type="entry name" value="PRK08256.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870:SF1">
        <property type="entry name" value="NON-SPECIFIC LIPID-TRANSFER PROTEIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22691">
        <property type="entry name" value="Thiolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="10">
        <location>
            <begin position="12"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="11">
        <location>
            <begin position="269"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF08542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="461" mass="49971" checksum="2D7EE44086454B12" modified="2013-05-01" version="1">MAAKAGKNKPPVYVLGVGMTKFIKPRGKVDYTELGFEAGIKALIDAQTNYDEIDAGVACYCYGDSTCGQRVFYQFGMTQIPIYNVNNNCSTGSTGLHLGRTMIAGGMADAVLVVGFEKMNPGSLQSYFLDRANPTGTTGQMMMATRGRTNAPEAAQLFGNAGREYMEKYGAKKEDFAEIGRINHEHSKRNPYSQFMDEYTLEQVMNSTTIHEPLTKLQCCPTSDGGAAAVLVSEKFLQERPHLRDQAILIAGQTLATDAPSLFSRSAIDLMGREMTAYAAKTAMEEAGIKPGDVKVCELHDCFSANEMITIDALGLSPHGKAHEMVRNGDITYGGKMVINPSGGLISKGHPLGATGIAQCSELVWHLRGWANNRLVPDTTVALQHNLGLGGAVVVTVYKRADGGAPKKMSDEEVVKATKIGYNPATEARGFTKSQADAVRSRKQRSEWALQDIQKKVESRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M3CY33</accession>
    <name>M3CY33_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2',3'-cyclic-nucleotide 3'-phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_74374</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756717.1">
        <property type="nucleotide sequence ID" value="XM_016910062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CY33"/>
    <dbReference type="STRING" id="692275.M3CY33"/>
    <dbReference type="GeneID" id="27907199"/>
    <dbReference type="eggNOG" id="ENOG502S8HR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108991_1_0_1"/>
    <dbReference type="OMA" id="WLDSIPW"/>
    <dbReference type="OrthoDB" id="514292at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004113">
        <property type="term" value="F:2',3'-cyclic-nucleotide 3'-phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009187">
        <property type="term" value="P:cyclic nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012386">
        <property type="entry name" value="Cyclic-nucl_3Pdiesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28141">
        <property type="entry name" value="2',3'-CYCLIC-NUCLEOTIDE 3'-PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28141:SF1">
        <property type="entry name" value="2',3'-CYCLIC-NUCLEOTIDE 3'-PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07823">
        <property type="entry name" value="CPDase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="LigT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF08596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="219" mass="24556" checksum="AE07D858DABDFC33" modified="2013-05-01" version="1">MPLSLWFILQKGNSFEKTAQELISQTIPNIFFTPDQLQQNNHHTFPPHVTITSGISFPSDGSGPTPQEWLDSLDCSAYQSQHNEIKLELDTVQAEDAFFRKCNIALKEDSNLMEFATMCRRHASTTTTTSEEEEKYRPHLSLLYADLPTSTITSKLPLIEMKVGFAIGDLFACCGGALCIGGRMVLVDTGSRPIGEWKDAVVAERETPFVQWRITRNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M3CZZ1</accession>
    <name>M3CZZ1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_119549</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF09808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757929.1">
        <property type="nucleotide sequence ID" value="XM_016901519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CZZ1"/>
    <dbReference type="GeneID" id="27898656"/>
    <dbReference type="eggNOG" id="ENOG502SBVF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063948_0_0_1"/>
    <dbReference type="OMA" id="TIDTWIE"/>
    <dbReference type="OrthoDB" id="10010954at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032726" evidence="2">
        <location>
            <begin position="21"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF09808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="369" mass="39945" checksum="FBCD94C7D535845F" modified="2013-05-01" version="1">MRFSIYISACLALLLNQAFATDHLHHQHHHSPRTDSSPLSKRQLPSFAERNLATIRAIYNLTVYPNNDPIVKLGSSQVPPGLFSPSAVGRVSPVGEFSGFNDSIEYFFALAPVPSDPEFQGVAIYQADVVEFTSGCPGIAASLVYLRTGKVDPKTGEVDSRVPVSTLSQVAFWQFDEYGQVERYHAWIPNLEAWVQAGTGFDFGALLIQKFIPVSLCPMIQQRCTGPNQVYSSVLDCAVELELKPFGSFDEAWGDTVACRVIHLILTQVRPDVHCPHVGPTGGGKCSAIGYSEDYFSDWELFGIPEGSVFTCGGPLTDPRNPAAVGPYSGTDGRPLPGSAPPPIPDVKQALGPLGGLLSGVVKRMPEWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M3D1V1</accession>
    <name>M3D1V1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_68386</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759223.1">
        <property type="nucleotide sequence ID" value="XM_016909818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D1V1"/>
    <dbReference type="STRING" id="692275.M3D1V1"/>
    <dbReference type="GeneID" id="27906955"/>
    <dbReference type="eggNOG" id="KOG3085">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_8_0_1"/>
    <dbReference type="OMA" id="WWRQLIA"/>
    <dbReference type="OrthoDB" id="444127at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.720">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051828">
        <property type="entry name" value="HAD-like_hydrolase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044924">
        <property type="entry name" value="HAD-SF_hydro_IA_REG-2-like_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46191">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46191:SF2">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF11102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="303" mass="34060" checksum="E8D67356805A9563" modified="2013-05-01" version="1">MPPPLASRNLLICFDAFGTLFTPKLPIAKQYGNVARSFGLTGSFTDEDVGRAFKVAFKNETKRNPNYGKMNGLDPEMWWSRIITNTFKPLIPEDQSVPQAMVTKLLHRFWCDEGYTLFPDVPPLIRKLREAHHAREEDRCTRVMIGVITNSDNRVPDVLSSLGLTVSSLRYGNHNAFAAASKDHQEYDVDFSVMSYDVGHEKPDQRIFQAAEEVLSVALDDGKHDAGEWRKVYVGDEFDKDVVGALSAGWKAVLIDRETTGPRDDLKWLDDEPVGSLYEVFDSAKAVGFSSLDKLGQWLPTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M3D2J2</accession>
    <name>M3D2J2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Phosphatidylinositol transfer protein SFH5</fullName>
            <shortName evidence="15">PITP SFH5</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SEPMUDRAFT_88853</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Non-classical phosphatidylinositol (PtdIns) transfer protein (PITP), which exhibits PtdIns-binding/transfer activity in the absence of detectable PtdCho-binding/transfer activity. Regulates PtdIns(4,5)P2 homeostasis at the plasma membrane. Heme-binding protein that may play a role in organic oxidant-induced stress responses.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(out)</text>
            <dbReference type="Rhea" id="RHEA:38691"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:38692"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 15">Endoplasmic reticulum membrane</location>
            <topology evidence="2 15">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Microsome membrane</location>
            <topology evidence="15">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the SFH5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759483.1">
        <property type="nucleotide sequence ID" value="XM_016910486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D2J2"/>
    <dbReference type="STRING" id="692275.M3D2J2"/>
    <dbReference type="GeneID" id="27907623"/>
    <dbReference type="eggNOG" id="KOG1471">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045138_2_0_1"/>
    <dbReference type="OMA" id="KFIRARE"/>
    <dbReference type="OrthoDB" id="75724at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017157">
        <property type="term" value="P:regulation of exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042938">
        <property type="entry name" value="Sfh5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47669">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN SFH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47669:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN SFH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11 15" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15" id="KW-0492">Microsome</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="17">
        <location>
            <begin position="140"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="310"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="318"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="385"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMF11362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="437" mass="48116" checksum="1C0326BC75B4D077" modified="2013-05-01" version="1">MAGDWNNLPEGHKLKKFHAELGEILSSTGYNEMYGVELQPPAEGKSPSHSTLIILQKFLRANVDDLEKAKEQLTASLKWRKEYQPLKARDEAFDGEKFGKLGYITRVKGVKGSQNAEDVATFNIYGAAAKDFKKTFGDTDAFLRWRVAQMELTLKELDLNAADQTIPDYGKGPDPYKAIAVHDYLSVSFFRQPSEIKTASTKIIDMFQRYYPETVGQKFFVNVPLVMQWMMGAMKALLSKDSIQSMTWMTYGSQLKDYLGADIPKEYGGTGAPLAETAITPKYGKEEAQKDTPAPVVAPVVAPVVVPVAAPASTDPPAEEKKAEESKVEEKKVEEKKVEEKKVEEKKVEEKTEEKAEEKAEEKKAEEQVVEEKKVEDKKVEQPLAEPAEPAAPAEPATAEPTSAAVVPEAATENAGATVATANPSEVIDTPEEKKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M3D402</accession>
    <name>M3D402_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RED-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_149449</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761031.1">
        <property type="nucleotide sequence ID" value="XM_016905558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D402"/>
    <dbReference type="STRING" id="692275.M3D402"/>
    <dbReference type="GeneID" id="27902695"/>
    <dbReference type="eggNOG" id="ENOG502RZ6M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017393_0_0_1"/>
    <dbReference type="OMA" id="LKSTHMV"/>
    <dbReference type="OrthoDB" id="3366823at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039896">
        <property type="entry name" value="Red-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012916">
        <property type="entry name" value="RED_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12765">
        <property type="entry name" value="RED PROTEIN IK FACTOR CYTOKINE IK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07808">
        <property type="entry name" value="RED_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RED-like N-terminal" evidence="4">
        <location>
            <begin position="72"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="225"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="279"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="332"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="356"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="480"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="508"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF12910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="541" mass="59555" checksum="770912F31DC8B4A0" modified="2013-05-01" version="1">MNNDAFRKLVASTPARQDDGATPARPGALGTKKSSFVPMTPRPGKATGSDDFARQVREQHAQMRPPKKYKSSAPKGSKFGSGYVDRAKARQAGEEDQDDRAERIKALEEQAKLGQIPWETFEALRDKITGGDVSSTHLVKGLDRQLLERVRRGEDVLGLGKKDEEETVQEVDVDDELEKLGEQEVATIQKTQTEKKGTKAVGPIAGKKRTRDELLAELKAQRKAAAEAKAANAPKLDGRWKKIGDQSQPKVEFDHKGREVVTVVQEDGTVKKMVKKAASAAIESKATIDMPDLSQPVLGADVAIPEQKQPEPDEDSDDDIFAGAGTDYNPLGDEEDDDDDSDSEDDGKAKPSKKPVALEKPKEDDDRDERAKDKSPSEHEGPVPTTKSARNYFGEGTSQNDEDAEKNRFKGIENVLKKAANLAADKTGSDDDEDDDPATREEREARKAKRARMLAQQDRDMDDMDLGFGGSRGEDEEDGMDSKVKFAEWKGGKTAGDDGWEEDDGKRGEKKKRKPKKRKGDVNNAADIFRVIEGRKAKENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M3D479</accession>
    <name>M3D479_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SEPMUDRAFT_126049</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit APL3 and beta-type subunit APL1), a medium chain (mu-type subunit APM4) and a small adaptin (sigma-type subunit APS2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <location evidence="2">Coated pit</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF13000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761121.1">
        <property type="nucleotide sequence ID" value="XM_016902031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D479"/>
    <dbReference type="STRING" id="692275.M3D479"/>
    <dbReference type="GeneID" id="27899168"/>
    <dbReference type="eggNOG" id="KOG0935">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061221_3_2_1"/>
    <dbReference type="OMA" id="QSNFVEY"/>
    <dbReference type="OrthoDB" id="371463at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030122">
        <property type="term" value="C:AP-2 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14833">
        <property type="entry name" value="AP2_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000011">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027156">
        <property type="entry name" value="APS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0168">Coated pit</keyword>
    <keyword evidence="6" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="13">
        <location>
            <begin position="3"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00062168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMF13000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="145" mass="17023" checksum="7B048AA34E4E407E" modified="2013-05-01" version="1">MVISFILIQNRQGKTRLAKWYSPYNDDEKIKLKGEVHRLVAPRDQKHQSNFVEFRGSSKIVYRRYAGLFFCACVDSTDNELAYLEAIHFFVEVLDQFFGNVCELDLVFNFYKVYAILDEVFLAGEIQETSKQVVLTRLEHLDKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M3D4C8</accession>
    <name>M3D4C8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">rRNA methyltransferase 2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_149320</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760865.1">
        <property type="nucleotide sequence ID" value="XM_016905487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D4C8"/>
    <dbReference type="STRING" id="692275.M3D4C8"/>
    <dbReference type="GeneID" id="27902624"/>
    <dbReference type="eggNOG" id="KOG4589">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009422_2_0_1"/>
    <dbReference type="OMA" id="WSQVAVN"/>
    <dbReference type="OrthoDB" id="20105at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008650">
        <property type="term" value="F:rRNA (uridine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF18">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="7">
        <location>
            <begin position="89"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF12744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="337" mass="37584" checksum="1CBC32703A923E07" modified="2013-05-01" version="1">MLARTVGQIPCAAIAKRQLACERAWGSCIIAPGLPVRRQWSGQLEHQQRRPLLVLLLQNRYASSSSSTRWKSRQGRDSYAREAKVAGLKSRAAFKLLEINEKYKLFRMGDTVVDLGFAPGSWSQVAVNRTSPGGRVVGIDIIPAQPPRGANALQGNFLSAEIREEVRKFVSDPDRGRVRSRTIVEDDVTEEDLQQEHQGIVQLEMHAAQNEKKLKEIPKADMTQKQLDLAEGRVVNVVLSDMLMNTSGIAARDHGGSMDLCMAALTFCFDTLSTGGNFICKFYTGAEDHAMEMRLKKLFEKVHRIKPDSTRKESKEAYFVGLRRKAGAKRAEVLEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M3D4S4</accession>
    <name>M3D4S4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Arrestin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_148589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761336.1">
        <property type="nucleotide sequence ID" value="XM_016905014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D4S4"/>
    <dbReference type="GeneID" id="27902151"/>
    <dbReference type="eggNOG" id="ENOG502SUAI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_586772_0_0_1"/>
    <dbReference type="OMA" id="FRYADIV"/>
    <dbReference type="OrthoDB" id="2333384at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF13215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="475" mass="51789" checksum="18CDE68B73655FFC" modified="2013-05-01" version="1" fragment="single">MIPSVSAAPPTRAKLGGLSTRVVLDDPNRVHYGNDIPVSGSLLLKYLPLLRGLPNSPLNAELFGPLQVEITLGGSARINHVNETRAEVFALVKEVVCIHDGPFRASPDEERRLPFAIRFPAHANPSSNTTGVRSWPLHEHVLPVEREALPPTCSVHLNHDAWETRKSAKWSSTTDTAMSVDYTIDTQVRMPGIKMEIVDATQQGGTSVLYDQPKIPLSIATCNQSLTSEFSQTFTAQNEALRPSSKRPHGVRNKTKALLKPAELPRFIFEAELIGIPKHAYVGRQLSFALSIIPHASSTVQTAPNLFLDSCTITLIAHTTGLQPAVIEIIKTKEAGFSSAKPYSEEYGWTKSINIGQLSWVPSTFTFRNITRTYKLRIAVQFSVGAQKMKMSRDVPLTIHPPVESDTTRVGTAEDPDGLPSYQEASYESRADLGPVPSYEQAMTTTTTTSSDAMPHDAAPSYGDHNVGFASASLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M3D4W1</accession>
    <name>M3D4W1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_63980</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761366.1">
        <property type="nucleotide sequence ID" value="XM_016909662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D4W1"/>
    <dbReference type="STRING" id="692275.M3D4W1"/>
    <dbReference type="GeneID" id="27906799"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_2_1_1"/>
    <dbReference type="OMA" id="GAICHAN"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF8">
        <property type="entry name" value="CYTOCHROME P450 2E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="478"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF13245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="606" mass="68898" checksum="43A805286E557C86" modified="2013-05-01" version="1">MAHVQSPAEQMLATATGSSSQLRIVDSLTASTSTLPAFQSPTFILAFLLVLSLVVTRVFKISKKQLPPGVKPLPRLPGLPYAGRFWDVPGPGIEAAWHFGALHKKYGPIYEWKVMGVIHIWIETDKISRDLFVTRQKNYCDRNELPAAVGVRDGAEILPLMGYGEKFRRYKNFMHLIMRHATPKTFYNWPSIENKRTLRRMLERPDRWSEHMLVHCARTIAGVAWGDPEHGSKLLKIIPVILKAVSPAGPVINKLTFLMNLPESVSPWKQQEALRKQEMTDAFVEALQDVKRRTEEGNCEDCWSKLWTTKEKGTEHLDDYEAAHAIGSSSFVAIATIGGPLHAFFTAMCHYPSWQAKVVEEIDRVCGNRPPEMTDMPQLPHLRATVKEIVRWRQATPLGVPHVVMEDDVYEGYHIPKGAICHANHYLISREESTYPSGNEFLPDRWLNPAYPTTYKEPLTEFPNLNNDRGFGYGNRSCPGVELTQCELFTLIGHLIWAFDIRRCEGKSAAENPVPWYETAPWVITMPKPFKCEIRVRSEEKKRWIEGNCPDGGGLVRDTEKERRNRWDVVRPRPRGGEEEGEEHFNWEGLTDRASGHAGRVYGVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M3D7I2</accession>
    <name>M3D7I2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">cAMP-dependent protein kinase regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_147949</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8 9">Tetramer, composed of 2 regulatory (R) and 2 catalytic (C) subunits. In the presence of cAMP it dissociates into 2 active monomeric C subunits and an R dimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the cAMP-dependent kinase regulatory chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762261.1">
        <property type="nucleotide sequence ID" value="XM_016904616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D7I2"/>
    <dbReference type="STRING" id="692275.M3D7I2"/>
    <dbReference type="GeneID" id="27901753"/>
    <dbReference type="eggNOG" id="KOG1113">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018310_0_1_1"/>
    <dbReference type="OMA" id="SQTRCVG"/>
    <dbReference type="OrthoDB" id="417078at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004862">
        <property type="term" value="F:cAMP-dependent protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034236">
        <property type="term" value="F:protein kinase A catalytic subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046580">
        <property type="term" value="P:negative regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046827">
        <property type="term" value="P:positive regulation of protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097271">
        <property type="term" value="P:protein localization to bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010603">
        <property type="term" value="P:regulation of cytoplasmic mRNA processing body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd12098">
        <property type="entry name" value="DD_R_ScPKA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000039">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000006">
        <property type="entry name" value="cAMP-dependent protein kinase type I-alpha regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050503">
        <property type="entry name" value="cAMP-dep_PK_reg_su-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012198">
        <property type="entry name" value="cAMP_dep_PK_reg_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003117">
        <property type="entry name" value="cAMP_dep_PK_reg_su_I/II_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635:SF152">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02197">
        <property type="entry name" value="RIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000548">
        <property type="entry name" value="PK_regulatory"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00103">
        <property type="entry name" value="CAMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00394">
        <property type="entry name" value="RIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47391">
        <property type="entry name" value="Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0114">cAMP</keyword>
    <keyword evidence="4 9 10" id="KW-0116">cAMP-binding</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="12">
        <location>
            <begin position="208"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="12">
        <location>
            <begin position="339"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="53"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="62"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="416"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000548-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF14140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="462" mass="50346" checksum="9501F70BB16F26F9" modified="2013-05-01" version="1">MSLPSDYTNEISALNREILKHQPQDTLQFCANFFQRRLESQRAEFLLSHRHSKQPGMAESTFPGSNPFTSTAPNQLAGSGGGMHSLAEEEEPDFASPTASSFPPNVREVSPSTSSDAVPPSANSGAGGSFGSFGFGAARDPNQPPPGANDSMSQSTFPNNYNMNRRTSVSAESLAPGAAEDSDWKAPSYPKTPDQLARLREAVSHNFLFKNLDEDQASQVLSALQEKRVPAKDIRVITQGESGDYFYVVESGSFDIYISDTGKAEQGQQGLGTKVASSGPGTSFGELALMYNAPRAATVVSHEPSVLWQLDRLTFRKILMDSAFQRRRMYESFLEGVPLLSSLTTYERSKIADALDTVKHPAGSTIIQEGDAGDKFYILESGEAIAVKRGREQQPLKSYEPGDYFGELALLEDKPRAASVISTTEVKVAALDKDGFQRLLGPVEAIMRRDDPRNQEDVGLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M3D9L5</accession>
    <name>M3D9L5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_148401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762921.1">
        <property type="nucleotide sequence ID" value="XM_016904900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D9L5"/>
    <dbReference type="STRING" id="692275.M3D9L5"/>
    <dbReference type="GeneID" id="27902037"/>
    <dbReference type="eggNOG" id="KOG3363">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074390_0_0_1"/>
    <dbReference type="OrthoDB" id="20681at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1230.10">
        <property type="entry name" value="MTH938-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036748">
        <property type="entry name" value="MTH938-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007523">
        <property type="entry name" value="NDUFAF3/AAMDC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21192:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21192">
        <property type="entry name" value="NUCLEAR PROTEIN E3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04430">
        <property type="entry name" value="DUF498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64076">
        <property type="entry name" value="MTH938-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF14800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="31828" checksum="2B1811AF659BA3F2" modified="2013-05-01" version="1">MAQNLLTSSAFASLPCTRKFAVESSARFGSFVGPSTRPCSAQHHRRIPAQRRATGPTTAEPRDSTAAVTWASKKAWASATAVARPTLHGRSGFSARGNVAAHALQTRSMHSTAHRSALSVKSHPSKNRDRGPESKEDTQTDFGAMNMLGNMVPPSTAVDACLDDGFALDSGLKVTEAGVLLVGGEAFKWRPWIREGEGNHSVGGRGAGKVKNAKGMFEVDKSVWGVLDLVWPKPDLLILGTGEKIVPVSPQTRRDIAALGIRIEVQDTRNAAAQFNMLATERGTQQVAAALVPIGWRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M3D9M2</accession>
    <name>M3D9M2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPI anchored protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_148404</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762926.1">
        <property type="nucleotide sequence ID" value="XM_016904903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D9M2"/>
    <dbReference type="STRING" id="692275.M3D9M2"/>
    <dbReference type="GeneID" id="27902040"/>
    <dbReference type="eggNOG" id="ENOG502RMEY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1152208_0_0_1"/>
    <dbReference type="OrthoDB" id="3935682at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032857" description="GPI anchored protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF14805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="255" mass="24785" checksum="41C2F8C109E4D6F1" modified="2013-05-01" version="1">MFSPQFSLLAIMASSLALSALAQDSSSSSSSSSTTASSADVTATTTTTSAPSINNAETTITALFGSATTGFVGSVVSANPCETTLAVVCDSEDPNPVDVCVLVPDVTATVILGPSAYAFIYATSTAGGLITIAESCDLDGPSGSFTGATCTASVYASIAGVSTSSATVATITDDAEFFSYAPVPITAGASSLPTAGATCDAEAAAAATQTERGDEDAERTSSAGAVPTARVGEVLYKILVPVGAAVVAAGAGGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M3D9Y3</accession>
    <name>M3D9Y3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DUF803-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_146916</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF14885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763006.1">
        <property type="nucleotide sequence ID" value="XM_016903959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D9Y3"/>
    <dbReference type="GeneID" id="27901096"/>
    <dbReference type="eggNOG" id="KOG2922">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012349_0_0_1"/>
    <dbReference type="OMA" id="PMVYISI"/>
    <dbReference type="OrthoDB" id="6428174at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF85">
        <property type="entry name" value="DUF803 DOMAIN MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G15880)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="333"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="409"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="347"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="433"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF14885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="483" mass="51825" checksum="55C845DB7B193048" modified="2013-05-01" version="1">MIEDKYIGLSLAVTSTLGIGASFVITKKGLNAAAQQNGFEGDGFAYLKNPIWWGGIITMVIGEICNFSAYAFAPAILVTPLGALSVLIGSVLGSYFLDERLGVLGRVGCAICLIGSVVIVLHAPPDQELNNIDELLHYAMQLGFLTYCTIVLIFALVMIYKIAPVYGKKNPMVYISICSTVGSISIMAIKGFGIALKLTLGGNNQFTHPSTYVFAIVVVVCILTQMNYFNKALATYSTNIVNPLYYVTFTTCTLTASFIMFRGFNTADAVNTISLLCGFLTIFTGVYLLNLSREDPDGMNAGIKSARDGRGQYHDIDGIPTDGLAGLQTRLSMQSRRSGELHHRRSNSWSLRSPRSRSSVDYGAAAVHSATTTNHMTRGGEQQQQQQTPPQHLLHAYDIEANALGDLAEDSDEDTLSGSNQKRTSFDRHSMGGMEGKGNGNGMGNGHGNGTLRNGTLPRKEKVVVATAGIGGGGKGFDSDPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M3DAP5</accession>
    <name>M3DAP5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SEPMUDRAFT_79037</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF14909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763030.1">
        <property type="nucleotide sequence ID" value="XM_016910209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DAP5"/>
    <dbReference type="STRING" id="692275.M3DAP5"/>
    <dbReference type="GeneID" id="27907346"/>
    <dbReference type="eggNOG" id="KOG0338">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_3_1_1"/>
    <dbReference type="OMA" id="MIDPPKQ"/>
    <dbReference type="OrthoDB" id="10259843at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17947">
        <property type="entry name" value="DEADc_DDX27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="16">
        <location>
            <begin position="234"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="265"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="466"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="99"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="667"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="234"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="110"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="667"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="705"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMF14909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="725" mass="80218" checksum="CC2105C664E6D7BE" modified="2013-05-01" version="1" fragment="single">MAIDDLIGTLSDGDVSDEESEVEEVVEVPVQTKKRKREAASQSAVKKQKGDNDADLDSDFEFENEGGAVELDDLDTWALAGNGEINEPGNIEAIIARKRAKNAPKAPVVDSEEENSDDSEDEGIAAAYEEEDDDEEDDDEAEPGADGEEDSEEEFSTAMEGLNGDFEGIDGNDEEDSGNEDDELDEDVEVAVHVPHPDDLADESGSEAAEDVLEKEKRNKFFANDEKSSNPAATAFHAMNLSRPILRGLAAVGFDKPTPIQAKSIPVALEGRDLVGGAETGSGKTGAFIIPILERLMFRPKRTATTRVVILMPTRELALQCFNVAKKLAAHTDITFGQAIGGLNLREQEKALKLRPDIVIATPGRFIDLERNSTGFDVSTVEILVLDEADRMLEEGFADELNEILTKIPKSRQTMLFSATMTTKVDDLIRSGLQRPVRLMVDSQQQTVKGLVQEFVRLRPGREKKRLAYLMYLCEKVYTDRVIIFFRQKKEAHRVRVIFALAGLKAAELHGTLSQEQRINAIESFRTGKAGFLLATDLASRGLDIKGIETVINYEAPQSHEIYLHRVGRTARAGRTGRACTLAAEPDRKVVKAAVKAGKAQGAVIKQRTIEAHDADAWHARIEAMADDIEEVLREEKEEKALNIVDKQLTKADNMVKYEDEIKSRPKKTWFESEKDKQAAKDRGRALLNGAEAMETKKKKGGKLSNKDRKKLQDKDDRKSGGEWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M3DB86</accession>
    <name>M3DB86_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_147079</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763235.1">
        <property type="nucleotide sequence ID" value="XM_016904071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DB86"/>
    <dbReference type="STRING" id="692275.M3DB86"/>
    <dbReference type="GeneID" id="27901208"/>
    <dbReference type="eggNOG" id="ENOG502RTDE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2251743_0_0_1"/>
    <dbReference type="OrthoDB" id="498125at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF15114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="104" mass="11618" checksum="A85B92F58B82415A" modified="2013-05-01" version="1">MVWLHPRSSLSLARQKADLRSRARKGRPHYETACGAMTATMIFSQEVQISPEDRASRRAVEIAVTRGVNEPSSQPSYRVLFCLPKDKHNTRGFGRKVYGVAASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>M3DCC7</accession>
    <name>M3DCC7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fungal_trans-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_105719</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763585.1">
        <property type="nucleotide sequence ID" value="XM_016900587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DCC7"/>
    <dbReference type="STRING" id="692275.M3DCC7"/>
    <dbReference type="GeneID" id="27897724"/>
    <dbReference type="eggNOG" id="ENOG502RHAD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006329_3_1_1"/>
    <dbReference type="OMA" id="CYFHYVH"/>
    <dbReference type="OrthoDB" id="4161332at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052761">
        <property type="entry name" value="Fungal_Detox/Toxin_TFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47425">
        <property type="entry name" value="FARB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47425:SF3">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="24"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="39"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF15464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="727" mass="80550" checksum="C7B44A221EA2917F" modified="2013-05-01" version="1">MSTRIRAGRANSMESKQARGKANACLRCYEKKIKCDMESLGQPCTGCTRDGVKCQKRSRKPYPPRREASSAASSTSSSSRGSPTRSKPGSTPPRSVPMERPQAPLFSPDQFHFSAPFLESPSYFTPIHDFSSNVMPHATVERSNTMTDTLPFFGGDEQDYAFLLSMCDASKDRKANALFGHKSSMGIMEPEALAYAEAKGCFSMPSHAVCEDLVQCYFHYVHPICPIMDIADFLEQYQGGALEGTSLLLLWSMFSVAANFASDSTLATHGYLSRAELKQTLHARAKCLYDLGYEQDPVTQIQSALLLGFWYSDMQDHVQSWHWTGIAISSAQSLGLHRDPDTLCLEHPVPSSRRRLLANIWWCCFFRDRWLSFEHGRPLRINADDCNVPMVSSDYLMQLPDRAPKSWHKYVSLELRHLGPIWIGLLQLTLVLDDILAANQSPRKTTLDIESMTSLERRIARCLPDKQARPFHSDVLLFFESHAQLHLEAAMIALYKPYASEFSSTSASTSTDPTLIRLANGRVKDASARTSGILDRIISSDTLRFAGPMIIPLLVPSMTIHLLQAKSHDQFTSSWSRSRLDQCLLVLKRLEANYPAAALVHQLFAGKRGSQAAALDVGSHDASTASLMDDSKRMSSSCGLDIARNHDMVHQWQGAPLDIHSTGSLCTPNRSAVAAAAATAQWSSPPNLEIVDPDFDLWNLTTPSEGPLFFPLDDVHMNGLEYGACAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M3DCV1</accession>
    <name>M3DCV1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Actin-like ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_38102</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763760.1">
        <property type="nucleotide sequence ID" value="XM_016908694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DCV1"/>
    <dbReference type="STRING" id="692275.M3DCV1"/>
    <dbReference type="GeneID" id="27905831"/>
    <dbReference type="eggNOG" id="KOG0101">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009958_6_2_1"/>
    <dbReference type="OMA" id="MGRCTSR"/>
    <dbReference type="OrthoDB" id="2963168at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF79">
        <property type="entry name" value="HSP70 FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G15200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF15639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="638" mass="70839" checksum="8304F5C81CA425BB" modified="2013-05-01" version="1">MPPPPINTGAGHAYAPQHQQQLYTQPAPPGYPMGQPPQGHQPYGYGPQAVQGPHSYNRGPAEVQGDNSRSKAQLIVGIDFGTTFSGVAFAFATNTEAKEDIIVEWPGAGTQTKQKIPTVLYYDQHQQVVGWGPDIAEALAPTGYPKPGVQKVEWFKLQLMLSGNTYIDPINLPPLPPGKSEIDVAADYLFKLRQAMRNSLQKTLGEVFNREERNIKYFLTVPAIWNDAGKAATRAAAIQAGFLRDENDNRLTLISEPEAAAMFCAKTGLLNLKVHDAVLIVDCGGGTVDLIAYEVEEESPFTVAECTAGSGDSCGSTALNRNFSNILRAKIRKMKLPDGSKTAGKVYAKCIMDFENRIKADFRNNGQKWAVDVGIEAEFPEAGIEEGYMTFTNEEILQCFEPVVNRILELVRNQIIAIQAQNRSLQNVLVVGGFGASEYLFQQIKLHVPPQFQNKVVRPMDSVAAIVKGAVTAGITERVVTSRVARRHYLMATLQPFKEGHHPEQYRVPSLDGKDRCKYTRQIFVQKGQRVKIGEPVKVSFFRQVAPGATLMYEDVLYACDEDVCPEYTKDPRIKEVVTLTSDLSRKNLEKDFERMDTPQGTFYRVYFDIYLTLDGSEFSAELVCQGEVMGRCSARFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M3DD90</accession>
    <name>M3DD90_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_147587</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763915.1">
        <property type="nucleotide sequence ID" value="XM_016904396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DD90"/>
    <dbReference type="STRING" id="692275.M3DD90"/>
    <dbReference type="GeneID" id="27901533"/>
    <dbReference type="eggNOG" id="ENOG502SBR7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1086522_0_0_1"/>
    <dbReference type="OMA" id="QKPRIHR"/>
    <dbReference type="OrthoDB" id="1112980at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027921">
        <property type="entry name" value="NOPCHAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38489">
        <property type="entry name" value="HISTONE CHAPERONE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38489:SF1">
        <property type="entry name" value="HISTONE CHAPERONE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15370">
        <property type="entry name" value="NOPCHAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF15794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="256" mass="27810" checksum="68856E0B3DC10DDC" modified="2013-05-01" version="1">MSTKRSCNDADLLLPICSTQTAAKRNKKLSPPPKLSNNSSEASMASTLFSDGAASDVTVASSVSSVDGPTTNTEPEEGTERASSTASDDSTSEDSSTMDDEADAEYEEDDEELEPVRVTSLPRPNRIAVEMGKPQIDPDVVMAYAKELESRLHAFLPKLRQANSELAEESAKLNMEQVDESKQHIEMNLDLGVLEQKPIKHERMSEGIRLPSRAAAPTRDESQILSPNMTVSALLHGRKDHAQDIKVEVMDTPDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M3DDG2</accession>
    <name>M3DDG2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_114927</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763980.1">
        <property type="nucleotide sequence ID" value="XM_016901116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DDG2"/>
    <dbReference type="GeneID" id="27898253"/>
    <dbReference type="HOGENOM" id="CLU_1994035_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF15859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="125" mass="14311" checksum="04D685D98167A263" modified="2013-05-01" version="1">MLEPFRSGCIAQRGPQLNPVSFGGQVGGIFAGQPRRRRLRTRTLFHHFVSLYGWRLEKDTPPYHHGNDLCISLLSPARLPPRLHDALDALVAADVRISPRHQAFAVRTIIWRWHFPVPPTTYKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M3DE53</accession>
    <name>M3DE53_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_18599</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF16045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764166.1">
        <property type="nucleotide sequence ID" value="XM_016908307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DE53"/>
    <dbReference type="STRING" id="692275.M3DE53"/>
    <dbReference type="GeneID" id="27905444"/>
    <dbReference type="eggNOG" id="ENOG502S5WK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098391_1_0_1"/>
    <dbReference type="OMA" id="SRQEAQF"/>
    <dbReference type="OrthoDB" id="19690at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF16045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="148" mass="16358" checksum="6167003448B3CFB1" modified="2013-05-01" version="1" fragment="single">FSSHAPLHARNRIYPVRIRNESELHTLILSSASSRIPLLTLWMTTWDAHSDTISSLIKTLLETEGVGEDQGSVSYVEVEMDSPDLGGVSAGIAQRYLITAIPTLLAFDRQEPQVETKVSRVEDLKSEEFLRSWIEREAARHGKGGAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M3DF64</accession>
    <name>M3DF64_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_131692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF16164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764285.1">
        <property type="nucleotide sequence ID" value="XM_016902443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DF64"/>
    <dbReference type="GeneID" id="27899580"/>
    <dbReference type="HOGENOM" id="CLU_1321631_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF16164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="208" mass="22997" checksum="100AA2EAB6A0E4FD" modified="2013-05-01" version="1">MSTPGDGACAYQRLNRASMIPTPSSPMGGSYQPASAFRRHTYGYPADLPSCLIPGLCPDPLQVRGQEPRMMQTRSAMTTSVPTSAAQRRPEPGPVHHIRPRPARREPKPEDLFLPTAAPLPPAPPAHGIRPRPQPRPRPADLYVCHATGTSRPPPSAGLTVVMERRRTHQLPDSTTKAKVECINYKGKNLLKRTRNFMYRQCQTLVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M3DF85</accession>
    <name>M3DF85_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_147819</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF16184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764305.1">
        <property type="nucleotide sequence ID" value="XM_016904541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DF85"/>
    <dbReference type="GeneID" id="27901678"/>
    <dbReference type="eggNOG" id="ENOG502RHKT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_792657_0_0_1"/>
    <dbReference type="OrthoDB" id="10580645at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF16184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="350" mass="40012" checksum="522201A8627C8A54" modified="2013-05-01" version="1">MPSRVSRAAPTPPVVARYTEESVEFQEAYEMARVDLERVDSVPLLTGPSDYHDWLRDFQIVCRQICVIDFFEGQEDLPLPPEAGEDAPVEEYNEYMLQLADWTGMNDSILECIRITCNPLMRSKIPTDVSTVSAARAILREECKPTFDLVMSLWRRLHEYTLDQAPDFLSFRYEFENRFEAFNRLEGGIVLDDNHKSLFFLCALGPEFSSWISITSQMYRIAGYSYGSKKDLTFHDLSSYAENYWHSIQRSKDTDLNVKAHRSSSSVASRKRTFDHRNGDGRPPFGVLLGPPDRPCQWPGHNGTGERGHTNGMCMKQNNDLCREFKKRFANGYTAAPYEGSPGFRGTSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDE9</accession>
    <name>N1QDE9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nucleoporin NUP49/NSP49</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_166109</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757521.1">
        <property type="nucleotide sequence ID" value="XM_016908202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QDE9"/>
    <dbReference type="STRING" id="692275.N1QDE9"/>
    <dbReference type="GeneID" id="27905339"/>
    <dbReference type="eggNOG" id="KOG0845">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027081_1_0_1"/>
    <dbReference type="OMA" id="KLPTHYH"/>
    <dbReference type="OrthoDB" id="2538017at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024882">
        <property type="entry name" value="NUP58/p45/49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13437">
        <property type="entry name" value="NUCLEOPORIN P58/P45 NUCLEOPORIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13437:SF2">
        <property type="entry name" value="NUCLEOPORIN P58_P45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21121">
        <property type="entry name" value="Nup49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="23"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="32"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="122"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF09400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="436" mass="46364" checksum="91F64F62D47FE218" modified="2013-06-26" version="1">MAFGRSNSLSLNTGATNSLFAQQTNNQAPPAGGSLFGNNTSSNNTSSLFGGGSNTTNQNNNSNTQQNQAPAGGSLFGNTTTNTNTNSIFGSTNNTANTNNMFSRPATTQAASGGSLFAPAASTNNTNNTGSNSMFGSTARQQAPSLLGATQSANLSQSTPFGRLGMGQSTSAPATQVAAAQVTIDNLKGTTRFEDCVDSVRQELENLDKMIQQQEQYAKQIEAFLPKHEEDVNSLLPDINFVKDKADDVEQSLATDAQGVDAQRRNAEKDSKDVQRLQRVVTNLTLPQPYQYPNLSTSGLGSMYASQQRTQQQQQNAQAGDENYDTDLIGNYFLPMAADLQKSMDSYASNLSEIEQHMRVIEASTVQQAQQLAQRRSGMGGAQPSNDEDTVRQLAGTLRGFEESILGVAGVVGDCRDGVTQLALGRLGTHINGSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDJ8</accession>
    <name>N1QDJ8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">TRAF-type zinc finger protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_166192</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757637.1">
        <property type="nucleotide sequence ID" value="XM_016908207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QDJ8"/>
    <dbReference type="STRING" id="692275.N1QDJ8"/>
    <dbReference type="GeneID" id="27905344"/>
    <dbReference type="eggNOG" id="KOG0297">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019709_1_1_1"/>
    <dbReference type="OMA" id="AREEDHK"/>
    <dbReference type="OrthoDB" id="1630758at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001293">
        <property type="entry name" value="Znf_TRAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131">
        <property type="entry name" value="TNF RECEPTOR ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131:SF94">
        <property type="entry name" value="TNF RECEPTOR-ASSOCIATED FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50145">
        <property type="entry name" value="ZF_TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="49"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="TRAF-type" evidence="7">
        <location>
            <begin position="194"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="TRAF-type" evidence="4">
        <location>
            <begin position="194"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="305"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="351"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="478"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="525"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF09516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="534" mass="59217" checksum="69B5F21A92BCC267" modified="2013-06-26" version="1">MRGMERLEKRRTMEERNFLISKARAQNFNPPVDLRLLDYIGDCDDNLTCPICRCPFVDPVVLADCDHYFCRDCIRQTWNASTAYNPLGPRGDCPTCRTPAKLNARSATSKILINIVDDLLVRCPKAEEGCKLEIKRGEVQDHVSIYCGFALIECPDYNCELPVRRKDSKDGCLHYPVSCIACREEMQKCYLEKHWKTSCPDRKVACELCKIRVYYRDLGEHKTRQCSANVIPCPGHALGCNNRSMKSQAERHTRSCAFAKMAPLFTAMTERMDEQEAAQKEMSRKLEVLENGFTSMHSILYTRIDDPDRTSADPSSIPLLQDHNRRSPAPTDDVASPMEEAELGFARLTHADVAPGTSPRSARHTTSRQTPDVPGPRPADSSEPFSPDFDLASPFPPPATNGPYASPLHHLLSMHESLRDEMSRVSAALQEVDGRHQMQTLNENLRTREEISYLTAQVAGLSRQVHWLTSAQLQRQGRSGTAGAGASGEAGPSVGAALSSAVQGAARMVSGAGREGTPPMPVRRGTSEEGRTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1QE59</accession>
    <name>N1QE59_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">R3H-associated N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_150672</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758752.1">
        <property type="nucleotide sequence ID" value="XM_016906325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QE59"/>
    <dbReference type="GeneID" id="27903462"/>
    <dbReference type="eggNOG" id="ENOG502S2TY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064119_0_0_1"/>
    <dbReference type="OMA" id="YPRHDPM"/>
    <dbReference type="OrthoDB" id="10256743at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02325">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025952">
        <property type="entry name" value="R3H-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039629">
        <property type="entry name" value="R3HDM4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32019">
        <property type="entry name" value="R3H DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32019:SF2">
        <property type="entry name" value="R3H DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13902">
        <property type="entry name" value="R3H-assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H-associated N-terminal" evidence="2">
        <location>
            <begin position="80"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF10631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="328" mass="37199" checksum="9757CD6C9AC82CF9" modified="2013-06-26" version="1">MAIHPELASASSPPSDPIERVEAWTVSLSQATDALAATSISSPPSHAPRVTIEIPLDEQALREDHPKPRREAVHTVYKKREPIRRDSVKRREALLKGKEGSRRRHRWENDRLLNNPHAEPPLPSDWQPTPTHTVQKVPYFLAPLWDAEYSRKTQERQQRAAAAKAPASREEAVAAQVTSELRAKLKKSRGAKNLLQGLEEEVRMFVCQWEQKQRELESEGLIEPDSSDDEIVFVGRNGAMSDDQRKEKEARHLRKDKLVFQSLVDENGAAFGRYLVHSIAQYYGLSTWSVTTGSPARREAYVGLKVDPITRRPSLTHSVLPRPLWTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>N1QEQ2</accession>
    <name>N1QEQ2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_150898</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759092.1">
        <property type="nucleotide sequence ID" value="XM_016906463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QEQ2"/>
    <dbReference type="GeneID" id="27903600"/>
    <dbReference type="eggNOG" id="ENOG502SB08">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115686_1_0_1"/>
    <dbReference type="OMA" id="GQGNIGH"/>
    <dbReference type="OrthoDB" id="2537432at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053203">
        <property type="entry name" value="Cisplatin_resist-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022024">
        <property type="entry name" value="DUF3602"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693:SF3">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693">
        <property type="entry name" value="PROTEIN PAR32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12223">
        <property type="entry name" value="DUF3602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF10971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="151" mass="15638" checksum="79BA668D05E1BD07" modified="2013-06-26" version="1">MSNPVHSTGRGGAGNIGHDTNNYVDGAIVREGAVGESGVPEYSAGRGGAGNMVQPTGSQLNKPSEEIVPESATRIGGADYDNFHTGRGGQGNIHKEKYGGHSSAKEQDAAIAKNSPKNSPHVGAQKESILEKVKHAVGLDKKEKTPEPTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>N1QF15</accession>
    <name>N1QF15_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LYC1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_151593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757768.1">
        <property type="nucleotide sequence ID" value="XM_016906914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QF15"/>
    <dbReference type="STRING" id="692275.N1QF15"/>
    <dbReference type="GeneID" id="27904051"/>
    <dbReference type="eggNOG" id="ENOG502S41G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038171_1_0_1"/>
    <dbReference type="OMA" id="TCWILVD"/>
    <dbReference type="OrthoDB" id="2020070at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055100">
        <property type="entry name" value="GNAT_LYC1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053013">
        <property type="entry name" value="LAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34815">
        <property type="entry name" value="LYSINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34815:SF4">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22998">
        <property type="entry name" value="GNAT_LYC1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LYC1 C-terminal" evidence="1">
        <location>
            <begin position="169"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="400" mass="44133" checksum="9281D78475639308" modified="2013-06-26" version="1">MGSINLPSTDSADVYLATATPEEAEALQHANSSEWKGALNVEAYLRREKYLGAQDLTKDGGLTSWVLVWQPGPAAERQVLSGCETIKKRALVSRDGNVEEVICHGLCSVFCPPAFRGRGYASRMMTEVGKKLENWQVDNGKAHLFSVLYSDIGKQFYAAKGWHPFPSSHITLPAKETPSAEGVRLLHSQDLAALCVADEDLIRARLKNRKAGSQTAVSIIPDLRTLAWTHAREDFVCNELYHKTPSIRGARVNDVWAYWARVWSDPTGHEPNTLHILRLVVEDDALGADFSPASAPGTEAINAAAEGRTPIHGVEASRVDEIRQSIAKIFQVAQTEAARWDMKEVVLWNPTSLALAGARQISPNVVVQEREVESIASLKWYGEGSGTEVEWVENMKYAWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1QF38</accession>
    <name>N1QF38_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_128300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757823.1">
        <property type="nucleotide sequence ID" value="XM_016902207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QF38"/>
    <dbReference type="STRING" id="692275.N1QF38"/>
    <dbReference type="GeneID" id="27899344"/>
    <dbReference type="eggNOG" id="KOG0927">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_45_1_1"/>
    <dbReference type="OMA" id="VRYYMRL"/>
    <dbReference type="OrthoDB" id="10255969at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050334">
        <property type="entry name" value="Molybdenum_import_ModC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43514">
        <property type="entry name" value="ABC TRANSPORTER I FAMILY MEMBER 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43514:SF4">
        <property type="entry name" value="ABC TRANSPORTER I FAMILY MEMBER 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="83"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF09702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="706" mass="78191" checksum="E2219757831057ED" modified="2013-06-26" version="1">MWRRLAVRARLTLKAPQCRRYHQHPRHVIKIDQATFYQTYPANTDTDTNTDSDSTNPPLFAKLDFHLPERTGPDGNPQYWAVCSPSSLARTTFLQVLAAQHICIPPAARTYPLLAEQSQSPQHAIKYVGFDADRGSSVSGTSVRGAYLSARYESRREETDFTVQDYLTGHTELNALHHEPSAVERSRLEDVLDRLKLRNLLQMPVANLSNGQTRRARIAKALVSLPEVLLLDGPFMGLDPNTARYMAAVLKDLAEQQSPRLIISLRPEDGVPEWITHLVVANSDLEVTAHGAKSELLASDLHLEGFLKPGLAKGPDTRRRRLNITKDGFREKSPPLPRGEPLVEMLGVKVQYGDKTILGDWTQTGPDGSEKSGLWWSLHRGQRCGIFGPNGSGKTTMLSLITSDHPQTYSLPIKLFGRSRLPAPGEPGISLFDLQQRMGHSSPEVHAFFPKHLTVRRTIESAWADAPLAKPRLTADVDRRVDAVLRWFTRELHPSHEGDTLLETLQKTLTKPAPRDPEAPLNAFAEYTSDDSDLIWAEHVTFRDLSFSSQRLALFLRAIVASPDLVILDEALSGVDERVREKALLYLSHGETMHLPDSSSSSSSSSSSSSSEESSSYYASAVAAAAAAPQKCILSRLGKITFGGLTPEQALLVVSHSKEDVPGCVREWICLPEPGEEGSRRGPRMGILRGPLELNPSAWEGQIWRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFH2</accession>
    <name>N1QFH2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">D-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="6">1.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_89625</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(R)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13521"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.4" evidence="6"/>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758608.1">
        <property type="nucleotide sequence ID" value="XM_016910505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QFH2"/>
    <dbReference type="STRING" id="692275.N1QFH2"/>
    <dbReference type="GeneID" id="27907642"/>
    <dbReference type="eggNOG" id="KOG1231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017779_3_0_1"/>
    <dbReference type="OMA" id="TASKIMR"/>
    <dbReference type="OrthoDB" id="7786253at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903457">
        <property type="term" value="P:lactate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000014">
        <property type="entry name" value="D-lactate dehydrogenase (Cytochrome), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748:SF83">
        <property type="entry name" value="DEHYDROGENASE (CYTOCHROME), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="8">
        <location>
            <begin position="37"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF10487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="465" mass="50364" checksum="A92308E73DA5435E" modified="2013-06-26" version="1">MLKAAKELAEALGQDAVSFDEDVIEHHGHSEWSTSNTAVRPVAVVYPKSTNDVVTIAQMCNKYKVPIVPFGAGSSVEGNFSSPHSGICVDFSLMDQVIAFRPEDMDVTVQPGVNWVDLNNQIAASGLFLPLDPSPTAQIGGMVSTNCSGTNAMRYGTMKDWVVNLTVVLADGTIIKTRRRPRKTSAGYNLTSLFVGAEGTLGLVTEVTLKLAPIPEDTSVAIVSFPTIKEAATAASSIIRSGIQLAALELMDDLQMQIVNRHGSASVKKRKWLEEPTLFLKFSGTTDAIKSDIKRVSQLMKPHNPRDFIFAKTPLEKTSLWAARKEALFTMLNTRPPGTEIWSTDVAVPLSQLANLITLTKQDCSQLNLFASIIGHVGDANFHTAILYDPRDAEQTAAVGKVVKQMMRRALEMEGTVSGEHAIGIGKKEGLEEEVGGEVVDVMRRVKRAVDGKGIMNPGKVFDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFS8</accession>
    <name>N1QFS8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_134026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760228.1">
        <property type="nucleotide sequence ID" value="XM_016902604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QFS8"/>
    <dbReference type="STRING" id="692275.N1QFS8"/>
    <dbReference type="GeneID" id="27899741"/>
    <dbReference type="eggNOG" id="ENOG502RHJV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_847775_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF12107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="32004" checksum="A1FD16EF779A50AC" modified="2013-06-26" version="1">MRFFASRSTPSMASIDKASTHRSRARSPPRPPAENVLQLLERLQHVQGDLIRIYTSEDLVEPIFVQEGLLRLVFRGSFWFERIMRQMEFEGTDRLVLHTQEDILALFVFWAFHTRVPGLHEFGKYHSIPSQDDEDDYQTLLVRTWVFADSVDLPAFQNALMVKLFDALDNPAKDLTAETLQICLLVSESATRMRWALVQYMLWWEDQSTRGMNDYEPTPHPRLQPYINIEEVKGIEADLHAAREVRSGMNNQERKKRPIAGLFFVCDPCAKSCWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFU1</accession>
    <name>N1QFU1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ubiquitin-conjugating enzyme E2 2</fullName>
            <ecNumber evidence="2">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">E2 ubiquitin-conjugating enzyme 7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin carrier protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Ubiquitin-protein ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SEPMUDRAFT_149925</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="2"/>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760304.1">
        <property type="nucleotide sequence ID" value="XM_016905859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QFU1"/>
    <dbReference type="STRING" id="692275.N1QFU1"/>
    <dbReference type="GeneID" id="27902996"/>
    <dbReference type="eggNOG" id="KOG0426">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030988_10_1_1"/>
    <dbReference type="OMA" id="RKVTRCV"/>
    <dbReference type="OrthoDB" id="19692at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990389">
        <property type="term" value="C:CUE1-UBC7 ubiquitin-conjugating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000837">
        <property type="term" value="C:Doa10p ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000839">
        <property type="term" value="C:Hrd1p ubiquitin ligase ERAD-L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180027">
        <property type="term" value="P:inner nuclear membrane-associated protein degradation pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd23796">
        <property type="entry name" value="UBCc_UBE2G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000008">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0882">Thioester bond</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 16" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="17">
        <location>
            <begin position="4"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="15">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00077195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMF12183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="166" mass="18716" checksum="E514AFABBD002EDD" modified="2013-06-26" version="1">MNTVASKRLFQEYKSLTIDPPEGITAGPINEDDLFVWEAIIQGPEGTPFEGGVFPAELRFPKDYPLMPPTMRFLGGGIWHPNVYPNGVVCISILHAPGDDPNHYEHASERWSPIQSVEKILISVMSMIAEPNDESPANIDAAKMWREQREEFEKRVRRDVRASLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGM5</accession>
    <name>N1QGM5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphodiest-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_145603</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764446.1">
        <property type="nucleotide sequence ID" value="XM_016903156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGM5"/>
    <dbReference type="STRING" id="692275.N1QGM5"/>
    <dbReference type="GeneID" id="27900293"/>
    <dbReference type="eggNOG" id="KOG2645">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017594_4_0_1"/>
    <dbReference type="OMA" id="DGHKFGP"/>
    <dbReference type="OrthoDB" id="415411at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009141">
        <property type="term" value="P:nucleoside triphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16018">
        <property type="entry name" value="Enpp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.180:FF:000003">
        <property type="entry name" value="Type I phosphodiesterase/nucleotide pyrophosphatase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151:SF120">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151">
        <property type="entry name" value="ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="606"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="619"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="629"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF16325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="689" mass="76064" checksum="5D0231639DD5D690" modified="2013-06-26" version="1">MAVEVNGSRSIGARDSLDSRDSESDSLERPSYSTAHYDEETLNAEEEAERLLMGGRDGRAGQNKIKRRNGRHDKWRGSRNMGNDSESMLKIEDGGRSSDDSANSSDVDALDLRAHQSSSKLAKCSRFTALHIIILVAFVAFAYGAYRASRSIARSSPSYAVKTLSNGTHDFAPTTVLISLDGFRADFLHRGLTPTLRSFVQQGVSPMYMMPSFPSLTFPNHFTLVTGLYPSEHGIVGNNFYDPVMHKQFTYADASLSMKPEYWNAEPLWATAELQGIKTAIHMWPGSEAHIGGVEPEYVDTYNGDEALHNKVNRILGWLDLPGPSAVETRENATRPQFIAAYVPNVDADGHRYGPNSTYIRSTIAEVDGMLELLFRGIEARNLSDIVNIVVVSDHGMATTDTTRLIQLDDLIDLKEIEHTDGWPLYGLRPFNQSEAKLAELYNALKVQEGLHEGKFQVFLRDDNMPERYHFSNNKRIAPLWIVPEVGYAIAPKHEFDVAAALEKGEIFHPRGLHGYDNDHPLMRAIFVARGPAFPHPKGSVVDPFYNTNVYNIICDSLGIEPRPNNGTIRLPFQTTGLHDPAAYEQPPDDPPPIAHWDGGAIVPSVVGTGAGSPPKETEAEEQAEPVAEEISAPASEPASEAEADQTEASEKPGDESTSWRQWIDGHIDQVKNWVTGLFGEHKTVTSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGT7</accession>
    <name>N1QGT7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">5'-3' DNA helicase ZGRF1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_165097</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758484.1">
        <property type="nucleotide sequence ID" value="XM_016908152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGT7"/>
    <dbReference type="STRING" id="692275.N1QGT7"/>
    <dbReference type="GeneID" id="27905289"/>
    <dbReference type="eggNOG" id="ENOG502S77U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_367304_0_0_1"/>
    <dbReference type="OMA" id="FDLFDWR"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052800">
        <property type="entry name" value="DNA_Repair_Helicase_ZGRF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018838">
        <property type="entry name" value="ZGRF1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28535:SF1">
        <property type="entry name" value="PROTEIN ZGRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28535">
        <property type="entry name" value="ZINC FINGER GRF-TYPE CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10382">
        <property type="entry name" value="ZGRF1-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="5'-3' DNA helicase ZGRF1-like N-terminal" evidence="2">
        <location>
            <begin position="23"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="481"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF10363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="760" mass="83881" checksum="74AA71B4F0C07542" modified="2013-06-26" version="1">MTAAMSKTAASLSVPLTQNTAPVLEYECLYTHDSRKKTKKWQDGFLRYHTFNKRVMVYDMPRNLIGDMHWTRAEAIQAGDELSLERNGVMVEVAEQIGQTETDLTALRNSKNRTTPKVQDSNHDGARRATAQTPRLQPAGPAARSGTQLKHKSLNALLGTPRGPIGIAQLPSRSPFEERYAPVEHEDWTDGRPPKRPRFDTAPARNVTRTTITPRSAEQTGTPLWACTADARKQKEEKMEKKKKASVAAGQQRMGTKEVINLSDDPPHSNEPLSALSDDLYAQSSPPTKRRPITSSNALGKSSSPASQAQRSKPKPIQEAMEPEPQGLEEEVVQPANPRKFAASKPDRQQRQRKDESGLHIGAKQPPMKEMLVHDASSTTQGSTSSKLGQALRLVSAGRKKRTLLCQDQLTRNPKRLSSTNTDDVGDSSLVQARDDAEEERPLTAREKVEARLARIEKRKKSVEGPLPTKRASVVESRDSPLNLDPNPNDDLPDGPSMGVFGQDSPSGGASTSHDASVIESARLDRLVLPRAAPPLQPGPQPQPRAVESVPVLPPPTLRRAVSDVASVQPSRSERLPAAPLRYTLSPPRSSHKSAPESGLGSGQVEPIADTQQKPANAACVLPGKLIHKKKGPLQKSVSLNITPSNGTSAVMLSKPFQRPGKAGAQRKAPEEPEDLGPWSREAFDLFGWRPPGWNEETWCMERTYQPSVQNKYRIPAYLPRHRKKERKKERKKSFFRPKTLDLREILGSKDLMAIYQQHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGY0</accession>
    <name>N1QGY0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_145720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764602.1">
        <property type="nucleotide sequence ID" value="XM_016903225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGY0"/>
    <dbReference type="GeneID" id="27900362"/>
    <dbReference type="eggNOG" id="ENOG502SWZV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158092_0_0_1"/>
    <dbReference type="OMA" id="WIMTGAV"/>
    <dbReference type="OrthoDB" id="3649628at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF16481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="101" mass="10937" checksum="D1894B6975630EAF" modified="2013-06-26" version="1">MATNKVRLYALTGAVAAITATGAWYGAGLNMRQELKEEKAKTHGATHEEKIAQLQSMRQHLVRSKEELQAKIDKLSGKNVPPGSTTTVGMQGTLEGRTRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGZ3</accession>
    <name>N1QGZ3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carbohydrate-binding module family 19 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_149634</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759855.1">
        <property type="nucleotide sequence ID" value="XM_016905679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGZ3"/>
    <dbReference type="STRING" id="692275.N1QGZ3"/>
    <dbReference type="GeneID" id="27902816"/>
    <dbReference type="eggNOG" id="ENOG502RGM2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2086297_0_0_1"/>
    <dbReference type="OrthoDB" id="3630276at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109567" description="Carbohydrate-binding module family 19 domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF11734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="117" mass="12376" checksum="20489B0E12741665" modified="2013-06-26" version="1">MKSTFFAAVAFAALSMAAPITKRQCYIDANGVQKCVSTPPQCTSHPDGTITCISQGSSSSSEAEKEAEEAATENSTLPPTYSSPPTKRQCYINKSGQQTCVKNPTCTTREDGTVVCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGZ8</accession>
    <name>N1QGZ8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Multidrug resistance protein 1, 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SEPMUDRAFT_149637</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759860.1">
        <property type="nucleotide sequence ID" value="XM_016905681.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.N1QGZ8"/>
    <dbReference type="GeneID" id="27902818"/>
    <dbReference type="eggNOG" id="KOG0055">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_17_2_1"/>
    <dbReference type="OMA" id="GFGQEEQ"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000102">
        <property type="entry name" value="ABC multidrug transporter Mdr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000009">
        <property type="entry name" value="ABC transporter B family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000251">
        <property type="entry name" value="ABC transporter B family member 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000302">
        <property type="entry name" value="ATP-binding cassette subfamily B member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF11">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="771"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="814"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="887"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="919"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1003"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1033"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="15">
        <location>
            <begin position="111"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="435"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="15">
        <location>
            <begin position="773"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="1097"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="688"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="699"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="714"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMF11739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1343" mass="147121" checksum="401743E8D3F6E63F" modified="2013-06-26" version="1">MVAEQPRGDSSSATPRSHHEVNVADQEKAMLGQTPFPTQLPIEPAPPLRKLDSKVETKQGEDDQKNEDAFAHLPEHEAAILRRQLEIPTVKVTYAKLFRYATTNDLLVMTLSAIMAIAGGAALPLMTIIFGTLTGTFQGYFQGTVPISEFSGEIGRLTLYFVYLAIAEFGATYIATVGFIYTGEHISGKIRQHYLASILRQNIGYFDKLGAGEITTRISADTNLVQDGISEKVGLTLQAVATFIAAYVIGYTKYWKLTLILTSSIVAIFLTMGALGQFIVKYNKASLSSYAEGGTVAEEVISSIRNAIAFGTQDKLAREYDKHLTIAEKSGFIMKAITGAMIGILMCYAYMTYALAFWLGSKYLVRGETSLSSIITIILSIMIGAFALGNVAPNIQAFTTAIAAASKLYSTIDRVSPLDPTSEEGTKLEQLRGVVELRNIKHIYPSRPEVVVMADVNLTVPAGKTTALVGASGSGKSTIVGLVERFYDPVGGAVFLDGVNVQDLNLRWLRQQISLVSQEPTLFATSIADNIRHGLIGTDAENLPAEKVRELVEKAAKMANAHDFICQLPEGYETNVGERGFLLSGGQKQRIAIARAIVSDPKILLLDEATSALDTKSEGVVQAALDKAAQGRTTIVIAHRLSTIRDADNIVVMQQGRIVEQGTHNSLLEKNGAYSSLVQAQKIAAENEKLEGEEEEEEHTPLNEKDRNLLQSESVDDEEDTNDLELGSSKSHQSISSKVLANKKQGGKSRSYSLWTLIKFVASFNKTEWQYMLLGLVFSIICGAGNPVQAVFFAKSITYLSLPEPYYGKLRSEATFWSCMYFMLAMVMFVSHVIQGIAFAFCSEKLVHRARDKSFRAMLRQDITFFDKEENSAGALTSFLSIETTHLAGVSGVSLGMLLLVTTTLVVGFIIALAIGWKLALVCISTVPVVLACGFLRFFMLTRFQARSKKAYMQSASYACEATSAIRTVASLTREHDVWNNYHGQIVEQEKNSFRSVLKSSSLYAASQSLTFLCIALGFWYGSKLISSGEYDMFQFFLCFSAVIFGAQSAGSIFNMAPDMGKARHAAAEMRTLFDLQPDIDTWSTEGETLTDVQGDIEIRDVHFRYPTRPDQPVLRGLDLQVRRGQYVALVGASGCGKSTTIAMLERFYRPLSGGIYVDGKEISTLNVNSYRSHLALVSQEPTLYQGTIRENILLGADTKPEDVPEASIVQACQDANIYEFILSLPEGFDTVVGSKGSMLSGGQKQRIAIARALLRNPKILLLDEATSALDSESEKIVQAALDKAAKGRTTIAVAHRLSTIQKADMIYVFDQGRIVEHGRHSELIAKKGRYFELVNLQSLGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1QHV0</accession>
    <name>N1QHV0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Anterior fat body protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_76410</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMP-30/CGR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764947.1">
        <property type="nucleotide sequence ID" value="XM_016910140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QHV0"/>
    <dbReference type="STRING" id="692275.N1QHV0"/>
    <dbReference type="GeneID" id="27907277"/>
    <dbReference type="eggNOG" id="KOG4499">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036110_3_0_1"/>
    <dbReference type="OMA" id="LWRCRAD"/>
    <dbReference type="OrthoDB" id="423498at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004341">
        <property type="term" value="F:gluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005511">
        <property type="entry name" value="SMP-30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907">
        <property type="entry name" value="REGUCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907:SF47">
        <property type="entry name" value="REGUCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01790">
        <property type="entry name" value="SMP30FAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="5">
        <location>
            <begin position="20"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR605511-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR605511-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF16826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="328" mass="36498" checksum="AF5397221A5EAA95" modified="2013-06-26" version="1">MPPIQKYKISHPYLDISCGLGEAPFYEKSHHSLRFVDIVKKKLHTIDLDEGVASHREFDLEFSIGTTADVEGVEGKFVFGGKSGYGVFERETGKHWIIKEMWSDAEKKDDGGGKPKKGTSRCDRMRSNDGSVDTKGRFYVGAMNDPAVLGDADITDEGIIFRLDPDLSIHRIKENIRIPNGMSWTRDNKTIYMTDSPTFEIQQFPYDAETGTISLEQGTTFFKCPIEGGQPDGHCQDEEGHFWIALYGTGKVVRVNPQGEVVAEVEVPTRCVTCPELCGTSLFITSAAEEDPEKYPWSTKYQGALFEVDVGVRGLPRNKFKPAAGVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1QI10</accession>
    <name>N1QI10_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Succinate-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="8">1.2.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_76415</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 8">
            <text>succinate semialdehyde + NAD(+) + H2O = succinate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13217"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 8">
            <text>succinate semialdehyde + NADP(+) + H2O = succinate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13213"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid degradation; 4-aminobutanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.16" evidence="8"/>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764951.1">
        <property type="nucleotide sequence ID" value="XM_016910141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QI10"/>
    <dbReference type="STRING" id="692275.N1QI10"/>
    <dbReference type="GeneID" id="27907278"/>
    <dbReference type="eggNOG" id="KOG2451">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_5_1_1"/>
    <dbReference type="OMA" id="VAACFRF"/>
    <dbReference type="UniPathway" id="UPA00733"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036243">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07103">
        <property type="entry name" value="ALDH_F5_SSADH_GabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000004">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000005">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010102">
        <property type="entry name" value="Succ_semiAld_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01780">
        <property type="entry name" value="SSADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF5">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="9">
        <location>
            <begin position="57"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00050387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00052698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF16830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="529" mass="56937" checksum="0799ADED74E2A977" modified="2013-06-26" version="1">MKSILTTLRRAPVVRSEIRHTGHLRLLSSTSSRKAHQIPPLKDKSLFKEQAYINGAWVNAQSGKTFEVHDPATGKVIGTMPEMNANDTNDAIAAASRALVSFRKTTARQRADMLRKWYNLMVENSEDLARLITWENGKPFADAKGEVGYASSFFNWFSEEATRITGDTIPASVAGNRIFTVKEPVGVCGLITPWNFPAAMITRKVGPALAAGCTVVAKSPGETPYTAAAIVDLGHRAGIPPGVINVVTSLQNTPEVGEAITSSNDVRKVSFTGSTAVGKLLMKQSSNTLKKLSFELGGNAPFIVFDDADLETAVNGAIASKFRSSGQTCVCANRIYVQKGIYEEFTKAFTEKVKQFQVGHGFDQGITHGPLIHDRAVSKVQAHVDDAVQNGGKVLAGGKMLPELGPNFYAPTVIRDMTSKMKISSEETFGPVAALFPFETEKEVVELANAAEVGLAGYFFSKDIQRCYRVAEHLQCGMIGINTGLISDPASPFGGVKDSGFGREGSKYGIDEYLIIKTMTLGGVGELQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1QI30</accession>
    <name>N1QI30_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">t-SNARE affecting a late Golgi compartment protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_142290</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760230.1">
        <property type="nucleotide sequence ID" value="XM_016902994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QI30"/>
    <dbReference type="STRING" id="692275.N1QI30"/>
    <dbReference type="GeneID" id="27900131"/>
    <dbReference type="eggNOG" id="KOG3202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061883_0_0_1"/>
    <dbReference type="OMA" id="EHDPYRF"/>
    <dbReference type="OrthoDB" id="546861at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21442">
        <property type="entry name" value="SNARE_NTD_STX6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15851">
        <property type="entry name" value="SNARE_Syntaxin6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.90:FF:000012">
        <property type="entry name" value="SNARE domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000006">
        <property type="entry name" value="Syntaxin 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015260">
        <property type="entry name" value="Syntaxin-6/10/61_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09177">
        <property type="entry name" value="STX6_10_61_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="143"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF12109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="235" mass="26479" checksum="6E2126FF33E8C4C0" modified="2013-06-26" version="1">MSNDPFEEAQADILSLLQQTRPLHQSYLRIRSTASSPSAPELVEARDELEGTLMDLSTDLQDLVDSVRAVEGDPYKYGLDVPEVQRRRKLVEEVGKEVEEMHKQLNQTVHAADQLAHPDSFGQDVNGADEDDDFGAWEEQRQMEMLHEQDEALDGVFQTVGNLRMQADTMGRELEEQAELLDDTENITDRVAGKLGTGMKKIRYVIEQNEDRWSGCCISALIVVLIILLILVVVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>N1QI62</accession>
    <name>N1QI62_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_146017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765006.1">
        <property type="nucleotide sequence ID" value="XM_016903401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QI62"/>
    <dbReference type="GeneID" id="27900538"/>
    <dbReference type="eggNOG" id="ENOG502R96F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_672657_0_0_1"/>
    <dbReference type="OMA" id="YPQMSPY"/>
    <dbReference type="OrthoDB" id="3908316at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="312"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="375"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF16885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="403" mass="45908" checksum="FEF0FA0F2696E137" modified="2013-06-26" version="1">MMHGACHGQGHVDVPIEEVRHHESEKHSGAPVFAWVDASSYKYMDHHRRTAEDEQRQQQQIRARSQTRSPRQWQEVPVSYRPREWHDYSEEVLPARTLTPPQNVPPFRQFQRQLGQPIQPLRPWKRPVALASTPSLQQYEAHASHINPALLYPQLSPYDGETTSTVLLDEPRQHLRSVSQPNTPSFMAIRTHSEEPDEYSLIAPAFPPSRITPPRSLAATTEAPFTDDEEFHLFVQATAGLGPEQHLRDSPTTVPSSDHQGPRRDTMQYSNNHNHRQHQQQQWDPPSSLVSPIHTEQTPTTLRALQHLAQMPQQQAPTNTTTFTLPRRPTPHRVVTDPIHASDGGLDLWMEPPSADHEDAVSPLEEDELPGYAESQAQAQAVQAEGARRRAQELARRWQQAHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>N1QIL3</accession>
    <name>N1QIL3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Clathrin adaptor, mu subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_149967</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <location evidence="2">Coated pit</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760385.1">
        <property type="nucleotide sequence ID" value="XM_016905882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QIL3"/>
    <dbReference type="STRING" id="692275.N1QIL3"/>
    <dbReference type="GeneID" id="27903019"/>
    <dbReference type="eggNOG" id="KOG0938">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026996_5_2_1"/>
    <dbReference type="OMA" id="VWKIPRI"/>
    <dbReference type="OrthoDB" id="10259133at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09251">
        <property type="entry name" value="AP-2_Mu2_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14836">
        <property type="entry name" value="AP2_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000002">
        <property type="entry name" value="AP-2 complex subunit mu, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043532">
        <property type="entry name" value="AP2_Mu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043512">
        <property type="entry name" value="Mu2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00991">
        <property type="entry name" value="CLAT_ADAPTOR_M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0168">Coated pit</keyword>
    <keyword evidence="5" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="10">
        <location>
            <begin position="168"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF12264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="441" mass="49083" checksum="C5386E009E83DA40" modified="2013-06-26" version="1">MLSGVLLFNQKGELLILRAFRQDMRPRLADVFRIQVISNPQIRSPILTLGSTTFSHIRSENIYIVGVSKGNVNSALVFEFLYKLVQLGKSYFGRFDEEAVKSNFVMVYELLDEILDFGYPQNTETETLKMYITTEGVKSERALEDSSKITMQATGALSWRRDNIKYRKNEAFVDVIEDVNLLVSASGTVLRADVNGAIEMRAYLSGTPECKFGLNDALTLGSHSGSLDGAAGPTGNLAGSKATKAAAGSVTLEDVSLHQCVKLSSFTTDRTISFIPPDGSFQLMSYRCSENVNLPFKVQVIVNEIGRTKVEYSIAIRANYGAKLFATNVSVRIPTPLNTANTTHRCSQGKAKYVPAENVIEWKIARFTGQSEFVLSAEAELSAMTNYKAWSRPPLSMQFSLLMFTSSGLLVRYLKVFEKSNYSSVKWVRYMTRAGSYEIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1QIV9</accession>
    <name>N1QIV9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-isopropylmalate synthase</fullName>
            <ecNumber evidence="3">2.3.3.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_118282</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21524"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.13" evidence="3"/>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760475.1">
        <property type="nucleotide sequence ID" value="XM_016901415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QIV9"/>
    <dbReference type="STRING" id="692275.N1QIV9"/>
    <dbReference type="GeneID" id="27898552"/>
    <dbReference type="eggNOG" id="KOG2367">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004588_3_2_1"/>
    <dbReference type="OMA" id="FRNTKEQ"/>
    <dbReference type="OrthoDB" id="418791at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054692">
        <property type="entry name" value="LeuA-like_post-cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002991">
        <property type="entry name" value="PRK03739.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46911">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46911:SF1">
        <property type="entry name" value="2-ISOPROPYLMALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22615">
        <property type="entry name" value="IPMS_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="6">
        <location>
            <begin position="28"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF12354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="447" mass="49946" checksum="7050404EF908DB8D" modified="2013-06-26" version="1">MESRYTSRPTTFDHTSREWPNKRLLKAPVIFSTDLRDGNQALPDPMTFEQKLEMYHLLVDIGFKEIEVGFPLASQLEFDFVRHLATTPGLVPDDVQIQVITLCREDAIKRAADALRGIKRVILQTYLPSSDNYRNTILQISEEEWIEQARKMTAYARSITKDSAQSEGTEWTYNFAFEDFSNARVDAVLRCAEAITDAWEPSANRDLMLTLAASMETIGPHVFADQVEYVHQNLSRRDQIRLSVHTHNDRGCAIASAELGALAGADRVEGCLFGNGERAGNMDTVTFALNMRTQGLETGLDMSRMDHIRRTVERITQIPVHPRAPYAGKYCLRAFSGGHQDAILKGVRLRAEAQAAGIETPYFPTWQVPYLPFDPSDTGCTLSDIIGVNSQSGKSAISWILLEKMGVVLAKQQAQEMAAVAKQSSSTVGRMLSTNEICDMYLQRVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJ57</accession>
    <name>N1QJ57_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Pre-mRNA splicing helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_150654</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758730.1">
        <property type="nucleotide sequence ID" value="XM_016906316.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.N1QJ57"/>
    <dbReference type="GeneID" id="27903453"/>
    <dbReference type="eggNOG" id="KOG0951">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000335_1_0_1"/>
    <dbReference type="OMA" id="MNPKEFN"/>
    <dbReference type="OrthoDB" id="5575at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000393">
        <property type="term" value="P:spliceosomal conformational changes to generate catalytic conformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18019">
        <property type="entry name" value="DEXHc_Brr2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18021">
        <property type="entry name" value="DEXHc_Brr2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000005">
        <property type="entry name" value="Pre-mRNA splicing helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000133">
        <property type="entry name" value="Pre-mRNA splicing helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000004">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000102">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000368">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein 200 kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000012">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000024">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000004">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000001">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000062">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000254">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041094">
        <property type="entry name" value="Brr2_helicase_PWI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048863">
        <property type="entry name" value="BRR2_plug"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF4">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21188">
        <property type="entry name" value="BRR2_plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18149">
        <property type="entry name" value="Helicase_PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039073">
        <property type="entry name" value="BRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="529"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="752"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="1380"/>
            <end position="1556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="34"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="247"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="274"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF10609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="2197" mass="247577" checksum="D08825BDD202B34D" modified="2013-06-26" version="1">MSKQGKGDPDNLGQYKYAAMSNLVLQADRRFVSRRGDDATGDPESLAGKIKLGEMGSRTARERAPVSGATNEGAKKRKRTEPVQSSRQAGILSAQDMNIEGLRYRPRTAATKDVYDLISSNVAQKMGGDYGLAITASATDSILEYLKDDGMKDFDRKKEIDDILGITLSSKEFNQLVNLGKKITDYDAQDDDQEMGGSNADEADMDEQQGVAVDFGDESEDDGANQTFEVREQNDESEDELAMGAEDAATDGAGSPPDADGGNEEDDDGMVIENRPRRTGREEKDPNFVAAHDIDAYWLQRHIGDIYDDAHIQAEKTREAEAIMSATDEAGEEKPLGQVENDLMELFDYDHHELVGKLVKNRDKIVWVTRWRRVAEDEESRVIVEKEMVNAGHASILKELRGRDEATGKTRMQVKLDPMQLDAKLEVKDDEDIKKDGLVGGMQPRKTLNLEDLKFDQGNHLMTNQNVRLPQGSTKRAFKGYEEIHVPAPKRKQVPGERPLIKLEELPAWARAGFGSNPSLNRIQTECHDSAFLDDGNMLICAPTGSGKTNVAMLAMLREIGKHRDPSTGRINLEEFKIIYIAPLKALVQEQVGNFGKRLESYGIRVAELTGDRQLTKQQIAETNVIVTTPEKWDVITRKATDTSYTNLVRLICIDEIHLLHDDRGPVLESIVARTIRRTEQTGDPVRIVGLSATLPNYRDVASFLRVDVSKDLFHFDGTFRPCPLKQEFIGVTEKKAIKQLKTMNDVCYTKVLEQVGQNKNQMLIFVHSRKETAKTAKYIRDKALELDTIGQILRSDAASREILRSEAESCQNAELKDVLPYGFGIHHAGMSRADRTSVEDLFADGAIQVLVCTATLAWGVNLPAHTVIIKGTQIYSPEKGSWVELSPQDVLQMLGRAGRPQYDTYGEGIIITTQAEIQYYLSLLNQQLPIESQFVSKLADNLNAEIVLGNVRTRDEGVEWLSYTYLFVRMLRSPALYQVGADYDQDEILEQKRVDLIHSAAVVLEKASLIAYDKKSGRLQSKDLGRVASHYYITHNSMMTYNLHIQPSVSPIELFRVFALSDEFKYIPVRQDEKLELAKLLGRVPIPVKETIDEPQCKINVLLQAYVSRLKLEGLALMADLVYVTQSAGRILRAMFEIALKKGWAQVAKDALDLCKMAEKRMWPTMTPLRQFLDCSPDIIKKAERMDVPWQSYFDLDPPRMGELLGMPKQGRQVCNLVAKFPRLEIQAQCQPITRSMLRVELTITPKFQWDDTIHGRAENWWIMVEDCDGEEILFHDQFLLRKEYAEAEMNEHLVEFTVPITEPMPPNYFISVISDRWMHAESKLTLSFQKLALPEKFPAHTQLLDMQPLTVEQLKRDEFINLYSGLGQFNKIQTQTFDALFRSDENVYIGAPTGSGKTICAEFALLRHFTKAEGGKAVYIAPFQQQVDIRCEAWKKTLGSLSGGKTIVKLTGETTADLKLLAEGDLILATPVQWDMMSRQWQRRKNVQSVELVVADDLHMLGGHGGYTYEAVISRTQAIKVQLENNLRTIGLSVSLSNAKDIGEWIGCSKRTIFNFSPNNRPLPLNLHLQAFNIPHFPSLMLAMVKPTYQAILQYAPEKPAMVFVPSRKQVRATAQDLLAACVAADSEDRFLRTEAEQLAPILTKVKEKTLAESLSHGIAYYHEALSDSDKRITTSLFQQGAVQILIVARDCCWEIQPAAHLVIVMGTQFFEGREHRYIDYPIAEVLQMFGKAGRPGEDKDARGVLMCPDTKRAYYKKFLGEALPIESQLLSYLHDAFVTEISTKTIESTQDAVDWTTYTYLYRRLLANPSFYGLTDTSHDGLSAYLSEQVEQTLKDLSDAKIIEIDEDEDTITPLNAAMIAAYYNISFITMQTLLLSLKRGTKLKGILEIVTAATEFEDIQIRRHEEHVLERIYERVPVKLAEVNFESPHFKSFLLLQAHFSRMQLPADLAKDQEIILRKVLSILSACVDVLSSEGHLNAMNAMEISQMVVQAMWDRDSPLKQIPHFEDDKIEVCSTFNIKDVVEFQDAMDPDENPDHGKLMAGLGLNHSQLADAARFINERYPNVELEFELADPENVASGQPSYVNISVTRQLEEDEEPNLQVHAPFYPAEKTENWWLVVGEESTKNLLAIKRVTVVRELKTKLEIVLPTPGKHELTLFLMSDSYVGVDQAPTFEVDAAEGMEEDDEEDDEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJA5</accession>
    <name>N1QJA5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_112423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764493.1">
        <property type="nucleotide sequence ID" value="XM_016900978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJA5"/>
    <dbReference type="STRING" id="692275.N1QJA5"/>
    <dbReference type="GeneID" id="27898115"/>
    <dbReference type="eggNOG" id="ENOG502RHPC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_191095_0_0_1"/>
    <dbReference type="OMA" id="WWKNVGM"/>
    <dbReference type="OrthoDB" id="241648at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF16372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="64" mass="7160" checksum="3910F948B8D13809" modified="2013-06-26" version="1">MAARTGRLKAKPHSKTWDMNRREVSARRQVGDAESVVNQQGSSTTTDGQGQQPWWKNVGMEEGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJM7</accession>
    <name>N1QJM7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nicotinamide N-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_145727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764613.1">
        <property type="nucleotide sequence ID" value="XM_016903229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJM7"/>
    <dbReference type="GeneID" id="27900366"/>
    <dbReference type="eggNOG" id="KOG2920">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032409_4_0_1"/>
    <dbReference type="OMA" id="RARWCIV"/>
    <dbReference type="OrthoDB" id="407325at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF104">
        <property type="entry name" value="N-METHYLTRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF16492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="214" mass="24048" checksum="62CAB78035BD0B97" modified="2013-06-26" version="1">MAECISAFRRSDEPEEEELEPEPDDAAPWSVKGRRVLELGAGVGLAGIVAVLARAREVVISDYPTDVVLENIRQNAMRAIPAALAKRYRVEGYAWGDVTSDFARAYAHSFDRIIAADCYWMSHQHENLVQSMLHMLSPAPDARVLAIAGFHTGRAKLTAFFEEAVSHGLVTEDIYEEDVQGVRREWAPERDGGREDMTGRKRWLLIAVLKRQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJT0</accession>
    <name>N1QJT0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PEBP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_146487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">SO2202</strain>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </feature>
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        </location>
    </feature>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF17460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="228" mass="25441" checksum="D823A7EC7B9651DD" modified="2013-06-26" version="1">MKLIILLVSLAASAVEAVIQQQQPLDSGTDFDLIRKLKIAEVIPTVMDEFKPMLTVNITWPKATALVGNTVKVKKVQHTPHVQLFGTLPNFYLTTQDDNEIPQLTLALTDPDARSRDNPDWSQMCHWIITNVPLATASDEAANEGWKEVEQIVEYQPPSPPKKSGKHRYVFAALVPKNGTSATLSLSKPQKRQHWGYGTVRAGLREWAEENGLEVVGANFIYAQDEKQ</sequence>
</entry>
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    <accession>N1QJW4</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_150810</name>
    </gene>
    <organism evidence="2 3">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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            </authorList>
            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
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            <end position="78"/>
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    </feature>
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        <location>
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            <end position="248"/>
        </location>
    </feature>
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            <end position="460"/>
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    </feature>
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        </location>
    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMF10839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
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    </evidence>
    <sequence length="555" mass="60870" checksum="4D9EC84124D13C1B" modified="2013-06-26" version="1">MAYERQSTGAQLLRPETADMPRQQLQQDLDKSASNIPDRTSPGQAQPEDLGAFADLESGNGVHDPASSMDCNEELPTSSTYRSNMYGCDEEDLGVLDQRTSTSHSGADFAELRRLKDDVTVNNPWIAAKLNASVRPLPTPRPSSPSPAHNDGFNPSDHVPDIRLARDGRVIGSSALARPEPYTPMSSASTYRHPEYNYAPTSDNSRGTPLEAIPDISSKPRRNPRRGPYQGQTNRPFVSPMTDQSSREKVWFDHLQGADRPRAPSTKRRKNAFNDHGGLVVQGELGDLVEDPRPMTPPLRNRDIRDFVGREEDASVGSMIAHDNRTRAESALRVPRSEREVLDLSGDDAADGRPHQTLDFVPASEILGLSERMGSQDQMFKRVLKRRKTSEKRALQEVDLNAVSHEPSKDRTTFDEEEYQPAAGKRTRSRRKSSSKLGRTKSSKLPLERIPPGKGTHDLAVTCSTSSQNISRMTEKPHIANALLGFNEPALPMADGMDSASSHLLSLAANLHGLLVSAGGDVDSPGPAALLSEVKAAFAERREVHEDEMLMPSGT</sequence>
</entry>
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    <accession>N1QL31</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_87196</name>
    </gene>
    <organism evidence="1 2">
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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            </authorList>
            <dbReference type="PubMed" id="23236275"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <proteinExistence type="predicted"/>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF11881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="102" mass="11741" checksum="1E028507E0798626" modified="2013-06-26" version="1" fragment="single">RLCRPRVEGQLPRLQASQEEAACSPQSCSWRTRLCKTKTDSTKLRPRCASVCFAATTTTDLFGQCHYAHRPDWPCQILQRFARSCSIATRWQWLSICTHPDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Sphaerulina</taxon>
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    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="eggNOG" id="KOG1650">
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32468">
        <property type="entry name" value="CATION/H + ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32468:SF0">
        <property type="entry name" value="K(+)_H(+) ANTIPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="430"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="8">
        <location>
            <begin position="58"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF16424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="895" mass="96745" checksum="4524355AA8CDEBC4" modified="2013-06-26" version="1">MATATVTQFVTQTVNSTAATATSTHRATPQGGILEGVDPTHYDPKNPIILFIIQAGIIIIFCRLLHWPLSKIRQPRVIAEVIGGILLGPSVMGRIPGFTAAVFPTASIPNLNNVANLGLVLFLFLVGLEVDLRFFFSNWKVALSVGAVGMILPFGFGCAIAWGLHHQFQGEPNIVDISFGTFMLFIGIAMAITAFPVLCRILTELQLLQTSVGIITLSAGVTNDVVGWILLALCVALVNAGSGLAALWVLLTCIGYGLFLFLAVRPVFIWYLRRSRALQDGPSQAVIVTTLLIALASAFFTGVIGVHAIFGAFMAGLICPHEGGFAIKITEKLEDLVGALFLPLYFALSGLSTNIGLLDNAITWAYVVGVIAVAFIAKFVGGTIGAKINGLVWRESFTIGALMSCKGLVELIVLNIGLQARILSTRTFTIFVVMALVTTFATTPLVQLLYPPWYQRKLEAWKRGEIDWDTGRPPSSSESDIVPHENEEFSKVRNLLVYLRLDNMPTLLAFVSLLGTKATEIVNKEHPMKGGEKFVEDSQAIEKSQRVNVHGVRLLELTERGSSVMKVTEVDEYSLLDPIINAFRVLGQMFNLSVSGEITVVPESNFADTLIQKAVEEVSDLLLIPWSETGTLSEKQAVSNDSIQIKLASESYSTFVQEALNTPQCNTAVFINQGFSGSLKPKQWSLPCSLSAMSVRSQRGHNTTFLNVDQSHHIFMPYFGMGADDLVALRIVLQLAENPGVTATIVHYESEESIETYAEDVTPTKPSESKKMEILRVLSLGTKTESTTGGPSALFTTLRKSMSADMARRVVFDTVRHSKDPVQDALAQAQQEVGQNPKNGGDIIVVGRNVNHFKQSGSTSSITSDCLGTAADTFAGSGIKASLLVVQAKDSGLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1QMH2</accession>
    <name>N1QMH2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ELMO/CED-12 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_145840</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764755.1">
        <property type="nucleotide sequence ID" value="XM_016903296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QMH2"/>
    <dbReference type="STRING" id="692275.N1QMH2"/>
    <dbReference type="GeneID" id="27900433"/>
    <dbReference type="eggNOG" id="KOG2999">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009191_0_0_1"/>
    <dbReference type="OMA" id="CPHMKDL"/>
    <dbReference type="OrthoDB" id="28413at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024574">
        <property type="entry name" value="ELMO_ARM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006816">
        <property type="entry name" value="ELMO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050868">
        <property type="entry name" value="ELMO_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771:SF56">
        <property type="entry name" value="CED-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771">
        <property type="entry name" value="ENGULFMENT AND CELL MOTILITY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11841">
        <property type="entry name" value="ELMO_ARM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04727">
        <property type="entry name" value="ELMO_CED12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16457">
        <property type="entry name" value="PH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51335">
        <property type="entry name" value="ELMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="2" id="KW-0581">Phagocytosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0729">SH3-binding</keyword>
    <feature type="domain" description="ELMO" evidence="6">
        <location>
            <begin position="246"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="550"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF16634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="709" mass="80077" checksum="CBF3ECF469C1A3D2" modified="2013-06-26" version="1">MEEPTDVATLVSSLNADSESARKYAVFKLKGLLRDPSFADAFIQYEGLPALRRAVLDTTGNTQAYALGSLDALLELDMGWECCDREIVEKALSLSISHPLVNIVRNALFLLVLVVSRPVVAGQDDESSAIYGFRAIRPALEQHPQFLESLVRRLSASDHQLCANALQLVNALMRDAVLNGAEHEWPKFVKSLQDLGVIGSVGMLMRGDAANYADSPLAIAVLEFQDLTKLLLRKWRDVMVNVELAEHKRALKTIHLLSNPEPYSPPPGTNGVKARKHHPEKWRRLGFETESPAWEFDETGYLGMMDLVDYTRRNEETFQKTLLEQSTIPREQRCPIARASLCVTLVLYELFEIDDSTTGDLPGYRNSFHRDQSVDRLYKPLLLQWGRLHTASLNTFIRLWKDAGAEHQDIYKIEEVVRVVVERIIGTAGRKTDIARVEDDLRLASLSTARKWQMENLNDVYQDAWGPHLVEVREQLRQESLQFMREQRIRCLLQGSWFPASAAADDTSWRYVRLSHNRRWLHYQNFPAQAEVAPSMADLPEKIDLNNVTSVDSNVSGPEAPRPATALKADDKGTETLPTSARGGSAKTSTTKITVLGTPTLEGRFAAPNRENELVLLELFPQTSHLASEWLDGLLMLLNQSPITKDTARLVAMIEDWGVRLRMLNLRWEDVDWDALERSAKGEQVAFRPVPSREGIEDGDFWYAMPDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>N1QMH8</accession>
    <name>N1QMH8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_153190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765269.1">
        <property type="nucleotide sequence ID" value="XM_016907504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QMH8"/>
    <dbReference type="STRING" id="692275.N1QMH8"/>
    <dbReference type="GeneID" id="27904641"/>
    <dbReference type="eggNOG" id="ENOG502RHUH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_931169_0_0_1"/>
    <dbReference type="OrthoDB" id="3650046at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF17148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="299" mass="31996" checksum="B7779CCF3327D677" modified="2013-06-26" version="1">MFDVGIEKRSSLCDSLQEPDNTHIAHGNTFLPTYEETLNDNLRNFGEPERHANLEAFDLIAEPKRGRRDCLKREYLIIAIIFFSLCAIALPLGLVYILRNAGSEQETATMQTRRAESSFSIAPVTAAILPTAIIPMTVYVTVTPTLEESIPIVTITVTASSPDVEPTTAGPQPTDTLTSLSISTDTALVSTAASLTSSQSTSWSLELSTSPVPTSISSVTIEPNLEASIQPELSQTSALYSPTDPTTTISPTTMEPSSTVSKVLQTAKGRFGFCGVSGSNCKRLLSGEKGTGTVKFGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNB8</accession>
    <name>N1QNB8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromatin associated protein KTI12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_146605</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the KTI12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765759.1">
        <property type="nucleotide sequence ID" value="XM_016903762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNB8"/>
    <dbReference type="STRING" id="692275.N1QNB8"/>
    <dbReference type="GeneID" id="27900899"/>
    <dbReference type="eggNOG" id="KOG3062">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027147_2_0_1"/>
    <dbReference type="OMA" id="THSRWDK"/>
    <dbReference type="OrthoDB" id="9972657at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013641">
        <property type="entry name" value="KTI12/PSTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12435">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08433">
        <property type="entry name" value="KTI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="132"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF17638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="335" mass="36807" checksum="E126B824CF0747C9" modified="2013-06-26" version="1">MPLILISGYPSSGKTFRSTQLIQNLQQKISESHEPRVKRLKIHHIDDTRLGLSREVYAAARAEKDARATLSSAIKRVLDRDTIVVADGMNYIKGFRYQLYCEAKAVQTTNCVVHIGTPADKCRELNELALKSSSSSSSPSSSPTTTTSSTAGAGAPAEKKGYSPSLFENLIFRYEEPNGMNRWDSPLFTIPFEDAEGPYEAIWEALIGSSGQAKIVRQNAATVLKPAAEQGYLYELDKTTSDVIAGITAWLQDHAGEGGGEVKVVVGTAAAAEEEKEEEEQVEGGLVVHLPVTAPSLPQLQRLRRQFITLNRQHSLSKARIRHLFVDYLNDSFQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M3AR80</accession>
    <name>M3AR80_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">rhamnogalacturonan endolyase</fullName>
            <ecNumber evidence="4">4.2.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SEPMUDRAFT_121481</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endotype eliminative cleavage of L-alpha-rhamnopyranosyl-(1-&gt;4)-alpha-D-galactopyranosyluronic acid bonds of rhamnogalacturonan I domains in ramified hairy regions of pectin leaving L-rhamnopyranose at the reducing end and 4-deoxy-4,5-unsaturated D-galactopyranosyluronic acid at the non-reducing end.</text>
            <dbReference type="EC" id="4.2.2.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the polysaccharide lyase 4 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.23" evidence="4"/>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF07969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756090.1">
        <property type="nucleotide sequence ID" value="XM_016901689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AR80"/>
    <dbReference type="STRING" id="692275.M3AR80"/>
    <dbReference type="GeneID" id="27898826"/>
    <dbReference type="eggNOG" id="ENOG502QTKY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037882_1_1_1"/>
    <dbReference type="OMA" id="FKIGDWD"/>
    <dbReference type="OrthoDB" id="114708at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102210">
        <property type="term" value="F:rhamnogalacturonan endolyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10317">
        <property type="entry name" value="RGL4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10316">
        <property type="entry name" value="RGL4_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10320">
        <property type="entry name" value="RGL4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.10:FF:000020">
        <property type="entry name" value="Rhamnogalacturonate lyase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1120">
        <property type="entry name" value="Carboxypeptidase-like, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029413">
        <property type="entry name" value="RG-lyase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029411">
        <property type="entry name" value="RG-lyase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016590">
        <property type="entry name" value="Rhamnogalacturonase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015364">
        <property type="entry name" value="RhgB_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36574">
        <property type="entry name" value="RHAMNOGALACTURONATE LYASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36574:SF1">
        <property type="entry name" value="RHAMNOGALACTURONATE LYASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14683">
        <property type="entry name" value="CBM-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14686">
        <property type="entry name" value="fn3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09284">
        <property type="entry name" value="RhgB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011794">
        <property type="entry name" value="Rhamnogalacturonase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004031741" description="rhamnogalacturonan endolyase" evidence="13">
        <location>
            <begin position="20"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase B N-terminal" evidence="14">
        <location>
            <begin position="21"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonan lyase" evidence="16">
        <location>
            <begin position="280"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonan lyase" evidence="15">
        <location>
            <begin position="364"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="49"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR011794-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF09284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF14683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF14686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMF07969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="506" mass="54537" checksum="9DC6C05721FB2151" modified="2013-05-01" version="1">MAIFNILLALLGFLPAAFAAFGLTENSDSFIVDAGSSNPLIATIRKSDCDIRSILYYGNQLQNPDSQGTHIGSGLGSATVTAQTISNKYIKITCETSTLTHYIVVVSGQSNLYMATYITAEPSIGELRYIARLDSSKLPDEYPFGDVSTTKPSTSTVEGSDVFVVNGQTRSKFYSSQRFIDDDVHCVGSGSLHACFVKPQYESSSGGPFFRDINSNNGGVYTSLTFYMNSGHVQTEKYRMGLHGPYALTFTRSGIPRLRDFDFSFFADLNIKGYVPTSGRGYVSGTATGTASGLDRIVHWYNDAAQYWADGTSGRFTSPAMKPGTYTMKLYQNELEVASQSVQVSAGSTTTSNIASALKEPSSRLWTIGVCDGQPTGFRNADKQLRMHPSDSRMSSWGPLTYTVGSSSLTDMPMAIFQSVNSPQTISFTLTSSQLGAATLRIRTTLAFASGRPSVVVNSWSGRVPAAPTRIDSRGVTRGAYRGYGEAYEFAIPAGTLKLDEGLTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M3AS31</accession>
    <name>M3AS31_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">4-hydroxybenzoate polyprenyltransferase, mitochondrial</fullName>
            <shortName evidence="11">4-HB polyprenyltransferase</shortName>
            <ecNumber evidence="11">2.5.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Para-hydroxybenzoate--polyprenyltransferase</fullName>
            <shortName evidence="11">PHB:PPT</shortName>
            <shortName evidence="11">PHB:polyprenyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_152012</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>an all-trans-polyprenyl diphosphate + 4-hydroxybenzoate = a 4-hydroxy-3-(all-trans-polyprenyl)benzoate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:44504"/>
            <dbReference type="Rhea" id="RHEA-COMP:9514"/>
            <dbReference type="Rhea" id="RHEA-COMP:9564"/>
            <dbReference type="ChEBI" id="CHEBI:17879"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58914"/>
            <dbReference type="ChEBI" id="CHEBI:78396"/>
            <dbReference type="EC" id="2.5.1.39"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Mitochondrion inner membrane</location>
            <topology evidence="2 11">Multi-pass membrane protein</topology>
            <orientation evidence="2 11">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.39" evidence="11"/>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756440.1">
        <property type="nucleotide sequence ID" value="XM_016907187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AS31"/>
    <dbReference type="STRING" id="692275.M3AS31"/>
    <dbReference type="GeneID" id="27904324"/>
    <dbReference type="eggNOG" id="KOG1381">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034879_2_1_1"/>
    <dbReference type="OMA" id="SHENENH"/>
    <dbReference type="OrthoDB" id="18170at2759"/>
    <dbReference type="UniPathway" id="UPA00213"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008412">
        <property type="term" value="F:4-hydroxybenzoate polyprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13959">
        <property type="entry name" value="PT_UbiA_COQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1780:FF:000001">
        <property type="entry name" value="4-hydroxybenzoate octaprenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000003">
        <property type="entry name" value="4-hydroxybenzoate polyprenyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1780">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01635">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006370">
        <property type="entry name" value="HB_polyprenyltransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01474">
        <property type="entry name" value="ubiA_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048:SF28">
        <property type="entry name" value="4-HYDROXYBENZOATE POLYPRENYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PRENYLTRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="269"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="51"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF08319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="424" mass="46306" checksum="E1CEC690E08AF02B" modified="2013-05-01" version="1">MASPRCFSSIYRPASFTRTSRQLQFLRQPVRTQRWTATTRSGLAIPVNTSRRSDAANSWQRKELRHSTSQSTSTPPTLPTPDIALQPYRLPTAGLLSYLPRTWVPYAELIRLDKPAGTYYLFLPCLFSTLLAAPLTNPIIPPTTVLYTSGLFFIGALIMRGAGCTINDLWDRDLDPHVSRTRLRPIARGAISVRQAVPYLGFQLFAGLALLVQFPTICLFYGVPSLLLVATYPLAKRVTNYPQAVLGLTFSWGAMMGFPALGIDLLSDVSALTSAACLYGSCVAWTIVYDMIYAYQDIRDDAKAGIKSIALAQEKNAKLFLSAVSAVQVGLLAGAGVAVGAGPVYFLGTVAGSAATSAYMIRNVKLNDIKDAAYWFFSGAWKWTGGVITLGLTAEYACHYFDVYDRTELEKHEPCPVPFAPPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>M3ASZ7</accession>
    <name>M3ASZ7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_159481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756760.1">
        <property type="nucleotide sequence ID" value="XM_016907849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3ASZ7"/>
    <dbReference type="GeneID" id="27904986"/>
    <dbReference type="HOGENOM" id="CLU_1850018_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004031056" evidence="1">
        <location>
            <begin position="17"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF08639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="139" mass="14966" checksum="0F1B53237E8257C1" modified="2013-05-01" version="1" fragment="single">MVRLTTCLAYITLALASSVAAGCDKHCNGCSSSAENPASHPGKDASEDGIAAVASAGTRVANVKILAPPENPLRSDRPNASVASIAAVAKARKITAYVKKLAPATTEALRRDLWRWRKWPRMLRGWKTWLLRLKEGDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M3AVS7</accession>
    <name>M3AVS7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome biogenesis regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_151192</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in ribosomal large subunit assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the RRS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758302.1">
        <property type="nucleotide sequence ID" value="XM_016906664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AVS7"/>
    <dbReference type="STRING" id="692275.M3AVS7"/>
    <dbReference type="GeneID" id="27903801"/>
    <dbReference type="eggNOG" id="KOG1765">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065163_2_0_1"/>
    <dbReference type="OMA" id="KMVYDEA"/>
    <dbReference type="OrthoDB" id="28455at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007023">
        <property type="entry name" value="Ribosom_reg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04939">
        <property type="entry name" value="RRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="65"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="142"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF10181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="191" mass="21487" checksum="EDA0A5AE398A5962" modified="2013-05-01" version="1">MATTSSPDNGEAQPYTFDLGNLLIQDPNPVPSHTTPSEKESILSALAQKCAQALIHQLLSQPITRDDKDGSLQISLPAPEFPLPREKPIPKEKEKTKWEKFAAKKGIKASRKDGKKVWDEEMGEWRDKYGFGARVLKRNPGEVERDWVQEVDEKKDAAKKEEGEKKGHGGKRKGMGDNANRDRKLSKKSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M3AWY1</accession>
    <name>M3AWY1_SPHMS</name>
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        <recommendedName>
            <fullName evidence="4">Altered inheritance of mitochondria protein 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_150215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759356.1">
        <property type="nucleotide sequence ID" value="XM_016906025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AWY1"/>
    <dbReference type="STRING" id="692275.M3AWY1"/>
    <dbReference type="GeneID" id="27903162"/>
    <dbReference type="eggNOG" id="ENOG502SPD4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009400_1_0_1"/>
    <dbReference type="OMA" id="PRPDWAM"/>
    <dbReference type="OrthoDB" id="5386574at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021582">
        <property type="entry name" value="Aim21"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11489">
        <property type="entry name" value="Aim21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="864"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
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        <location>
            <begin position="168"/>
            <end position="201"/>
        </location>
    </feature>
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            <begin position="272"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="299"/>
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        </location>
    </feature>
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            <begin position="320"/>
            <end position="335"/>
        </location>
    </feature>
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            <begin position="390"/>
            <end position="402"/>
        </location>
    </feature>
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            <begin position="509"/>
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        </location>
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        </location>
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        <location>
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        </location>
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            <end position="670"/>
        </location>
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            <begin position="725"/>
            <end position="737"/>
        </location>
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        <location>
            <begin position="783"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="805"/>
            <end position="826"/>
        </location>
    </feature>
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        <location>
            <begin position="827"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="873"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="893"/>
            <end position="902"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF11235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1003" mass="108442" checksum="757E2D1789ED61A5" modified="2013-05-01" version="1">MSTPAIPPRPQRNAQQTAPTAGRNDQPLVPPRPVRKTDPSPSRSPLNLPPTTMANRPAPRRTSQDLPRRPPSVSLPDIGHEGDEYSSFDQLPPEAHGVSVEKDNEQTRNVAADLPMHQPRASVPQSTATKNISKVTDTDSTTAAGLGIGRARPADDVHKLPPGDASPSRITRVTSNTRRAPSTEPPNSLRTKASFNRSTPTLVLERQVSRPGSVYGDDAEHGIPEIGQQIPLNRFAGDAQAPTPTGGQSAHAPGIGFFNDGSAKHHKKRHSRQEFLTHDSYGLEHDENHADQFEKEWMKKHPQEAAKEHHSRILPRPETAMTSDQLNRLIHSSDSGAAPMPSTPGEEDAYEEYIARMSPKVSTTDRKKRTSSGDVAPDSLFRKTFASKSLHPDHAIDDEHAPRRMSYYDSEDEHTQRDGTPILAADEMMKRPSSAFMPAAVIPEPRADDDYYYESGEDYHGGSRRNSRPSSRPGSVHGAQALHGYGGGSLHRYVSHEEVSHAGGGTPLEEIEEYEPLFPDEGEERSEKPKVLKKRSDVAAMHHFPSQDIWEDTPSSLQYSAEVSTPEVERQQEALEAEKTAHVGARTFETPEQEEARKQAGPDMTSSEKTFIKPHFKPGVLEDVKASHRPGAHRFPSSDVWEDTPSSMLGETTVSVPEMDDVRSPPEERATTSALPGSQDDLDARASTAGGLALSKPTIPSRPVRSSKLSEEKPGDEEVSPTKTKAPSIPAKPSIPARPVRPARGEGAPLEQSRSGGGDESVTSPPLPKAKPAVPARPGSKISALQGNFMSDLNNRLKLGPQAPHKKEEPQLNDEAAREPLADARKSRAKGPPRRKPAASAPAERKQTFTFAMSPLITCWTIDETDELQVQNESEKENKDPETAHDAPEAEQTLESNAQDNTDAAAPTEANDVASAISKSRHPSETAQGHASSADALKAALAEAGAGPAVAVIEEEGEKLPSAETVKSVVLDVPDTTETTGEVKAEVVPGAFPGEESELVVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M3AYU8</accession>
    <name>M3AYU8_SPHMS</name>
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        <submittedName>
            <fullName evidence="2">DUF1868-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_141595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016902970.1"/>
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    <dbReference type="GeneID" id="27900107"/>
    <dbReference type="eggNOG" id="ENOG502S6KF">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073317_0_0_1"/>
    <dbReference type="OMA" id="SLHMTLF"/>
    <dbReference type="OrthoDB" id="2877829at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08975">
        <property type="entry name" value="2H-phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="LigT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1868" evidence="1">
        <location>
            <begin position="18"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF12722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="231" mass="26419" checksum="FA33397C842BF3B4" modified="2013-05-01" version="1">MPPTRRPDPIGVPARVSRTGEIQIWPGNTVVCHLQEGSTLWHGLHIVQDALRQLEGPVQKMHLMPPGSWHMTVLDGVNEADREPGLWPPGKEQQPLDECTQDFLQRLSQLPPRLKAEGLAPPYMVQVAGIEVHPGGIHLKIECQSEDEEKRMRRLRDVLADTIGFRRPTHEAYQWHMGFCYLTKYLDEDEPEVRRVVSGVEAAVQIKFQLDALEFCKFETLHKFDRLLLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M3AYY9</accession>
    <name>M3AYY9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_149325</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016905491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AYY9"/>
    <dbReference type="GeneID" id="27902628"/>
    <dbReference type="eggNOG" id="ENOG502SXX8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_434235_0_0_1"/>
    <dbReference type="OMA" id="NIPYPAR"/>
    <dbReference type="OrthoDB" id="3643499at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF12762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="630" mass="70899" checksum="C29669D187E0CC53" modified="2013-05-01" version="1">MARPLSNDAGEGPRGRAATSLNHPQHSTRSWTHNGIHYTVHSTSYATPGLSFGSSSGTANGPFNFDPFMSSHRGHASRATPFGLLGSAFGLLENTLAMHPQHTIVGDHGFGQGSRRQVEIDTPNDNYDCDLAYEGHNLTPNRRARPKSIFSRLKDRLVDAKQHHREDSSSSRERSFEEDRSRRSSRRHSVYPAETRPPAREATKERPPEFIEVDYHDETDSEPEYTHSRGRTSSEQRSAADATMIESLEDAVELEERNVRGCKQKLANASKQANINSAYLQRIIDELKEHERRLAMAMNDLDEAKARRIRNKRPELPTRPLSYRRSEMPPREKSQEPPRSRPRQSQSTRNMREQFFDPFGGFPGHPPHADPVMQAFQNLHGLHAEHAMQFDPFNHFFEQSRPFAEDAHFRFFATPGDGFQQGAVPQGQKKRTRHSTGGAQPNVQHTYAPAGTANFARPLRRTPVAPQPPATVLRSDEAKRLFAAYDEKWKSLPSTNPDIPYPARGLHAGGLAARESLWAPHISTHVGSWSEETVMQANAQAFFLGVVGLSPMYTQHPATGRVEVGFDKSQATAQQIQQLVDILKKEKIRWHSDRLGRRNGGRSGPNEALQKDERARAVFHAVCELMERAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2022-12-14" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>M3AZ41</accession>
    <name>M3AZ41_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_149366</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760933.1">
        <property type="nucleotide sequence ID" value="XM_016905511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AZ41"/>
    <dbReference type="GeneID" id="27902648"/>
    <dbReference type="HOGENOM" id="CLU_1355416_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF12812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="202" mass="22250" checksum="3DE3B27426F4EA49" modified="2013-05-01" version="1">MVPAGLATSRAKSMSNLASPFASLSDSEEKLPLGWACADNLTLKLPDVTVGNNVYRPSLSRPTLPSRSRHALNRCPTLACRQTSCCFRCNECRPVMLIETSTRPNNSPLFTFYSNPDSHSRTSPSNTCRALAKAPKILVKVVRTLAAVAALSRLLLGVQHCPWGLCPSKHLQPRPIILNSRWLNSRWWLGVERGRILAYIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M3B162</accession>
    <name>M3B162_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_64458</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761623.1">
        <property type="nucleotide sequence ID" value="XM_016909681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B162"/>
    <dbReference type="STRING" id="692275.M3B162"/>
    <dbReference type="GeneID" id="27906818"/>
    <dbReference type="eggNOG" id="ENOG502S025">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_0_2_1"/>
    <dbReference type="OMA" id="QLFWLWL"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="29"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF13502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="352" mass="38996" checksum="03AE861E84B92D92" modified="2013-05-01" version="1">MNPSGHASPSAIYAVIFTFTALAILAVALRIYTRRVILRKLEQDDVLMFVALLCACCFTIARGFPLILASSAYYGLGHRLVELSEFQQTESLRWLWISIIFYHIGLPAAKLSIISQCIQVFGSIRTFKISARIVATVVLVYTVFTILITIFLCWPVDFFWQRNQPGRCLPRVPIWFFNSAFGAATDVAVAILPLPVVNRLIVPKRQRYLLMVVFALGGAVCIVTVIRFYSLYAVTTSDDYTWENPQAALYSNIELSVSIIGGCLPTYNAFVAKYFPRLYNAYAGPRGDPFGDIKLSFPQQSQKSVSSCVETMSTVESGKTALDNGCQGSYPDSKTMTTTLSTVPTVSTIRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M3B270</accession>
    <name>M3B270_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_149012</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761988.1">
        <property type="nucleotide sequence ID" value="XM_016905283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B270"/>
    <dbReference type="STRING" id="692275.M3B270"/>
    <dbReference type="GeneID" id="27902420"/>
    <dbReference type="eggNOG" id="ENOG502RG3J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_327937_0_0_1"/>
    <dbReference type="OrthoDB" id="6365676at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055499">
        <property type="entry name" value="DUF7071"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408:SF34">
        <property type="entry name" value="ZINC FINGER PROTEIN 672-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23257">
        <property type="entry name" value="DUF7071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="595"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="628"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="514"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="645"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="514"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="535"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="649"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="695"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="710"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="727"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF13867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="877" mass="98140" checksum="DD82A1F3B53A7828" modified="2013-05-01" version="1">MKNFTVDSKVDLLEHLIETSQTWDDPDLAAFFAHAQSTFKGFKGTTWEGADLEDKLRGEEKHWLSECDGSRSRRRGHEKGSYYDNAMGKWKKIWNELLIKDWQNELDNGRAFEEVPLSLREHLVRPKNVFAMAPHSPAPATTPKPRVALVKADPNQSSPTKPLEHQTPGESVAAKAKKLEFEYDGAKLKRVVDSAVEKAREIGKVDLADAVQMIYHDSQENFELRYLLDHILKQTADEEQNTRFQDYVRAAKRKIKMQRGQKHRSEMIKDGDRRAKKLLHRAKVAKESGKSSPPVVPTGEKLCDEKTWSSKCPCAQCLRDKAEYTEDATGVTDAEHQRKYEEFMRKNGLDAGKTKDSSRAPPPMYQHAVEIVSPVKKDSATWQVSKTSNEDDRVRTVDTDITQLGAEQHASKQGPQDSVQANGKLASAKTGGLSHSSYRTLPHHDPLVTEILGDLQYEPSVKKLLRQNRALPTNANIKDLRRRESALEAIKTIVTETPAAKTDLKVMAEKLEERDAREAEADGEVRSENQASAGAEDDSQYNNEQSDEESENEYKEDMDEDITPRSKRALRPRLSTAEIEETERDYSGRRRSHKWPCPLAKEAGCDQWFSSSGHAVRHGKIHTGIKDFTCPACDKAFARKDNMMEHFRGVHKNRVPSTKRGRRSSTQSSNAISEEADQRAEERAAKRRQSMRKNAAKDTTDSRASRDSSIVSGRSTDSSLTETFSTDEERHDPGNPESFGRHESVPREHEVVLHGSMIAQLSTTSEPAVLLARLEAKIDALIGRDANTMINGTSRQPHAEHAMVSSAESLLDIATSLQTGALHDQSPEFIQFVARLTRTAAEAVIDASNSAKASAAMAREISMMLEEQHGPAAQISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M3B2Z6</accession>
    <name>M3B2Z6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyltransferase family 34 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_10215</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 34 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762288.1">
        <property type="nucleotide sequence ID" value="XM_016900507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B2Z6"/>
    <dbReference type="STRING" id="692275.M3B2Z6"/>
    <dbReference type="GeneID" id="27897644"/>
    <dbReference type="eggNOG" id="ENOG502SHP1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039079_0_0_1"/>
    <dbReference type="OMA" id="INTHRVH"/>
    <dbReference type="OrthoDB" id="407658at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008630">
        <property type="entry name" value="Glyco_trans_34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306:SF8">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 34 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05637">
        <property type="entry name" value="Glyco_transf_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF14167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="242" mass="28130" checksum="ECA83128A5B3830B" modified="2013-05-01" version="1" fragment="single">KPRIATCTVAHGEHKEGYQRALSTHISHGDYHKYPTYLLDHPILDGLWSKESLLLELLLQELSKPKPEQLEWLVWFDADTVIMNKLIPLETFLPPEERSDVHLLYTKDWNGLNNGVFMLRVSTWSLELLSSVLAYRTFRPEDDLPFTEQSAMENVMQMDKYKAGAVQCPPQWFNSYPGDGDEGDVHFDHRPGQLLVHFAGVGDKSKAISDWIDKLEANRTRWEMPLSETNYERQIEEFWRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M3B3W1</accession>
    <name>M3B3W1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_148151</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762563.1">
        <property type="nucleotide sequence ID" value="XM_016904740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B3W1"/>
    <dbReference type="STRING" id="692275.M3B3W1"/>
    <dbReference type="GeneID" id="27901877"/>
    <dbReference type="eggNOG" id="KOG0265">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_2_1"/>
    <dbReference type="OMA" id="ILYMLPG"/>
    <dbReference type="OrthoDB" id="1068471at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052234">
        <property type="entry name" value="U5_snRNP_Component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44006">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44006:SF1">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="51"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="94"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="136"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="185"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="220"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="282"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="312"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF14442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="347" mass="37549" checksum="230AB94929A8B006" modified="2013-05-01" version="1">MSGEKRSADQTFGSSQLVKRQRSNGDMNGALIQSNGAGFGAKSLQAPVMELSGHSGEVFTARFDPSGAHIASGSMDRSILLWNTSGECENYGILTGHKSAILDLQWSRDSQVVYTASADKHVASYNVETGERIRRHVGHEEVINCLDVSKRGEEFLVTGSDDGSISIWDPRQKAALDFIETSFPVTAVCLAEAGNELFSGGIDNEIKVWDLRMKKVTYELTGHTDTITSLAISPDQQSLLSYSHDSTVRTWDVRPFAPADRAIKTFDGAQAGLEKNLIRACWDSEGKRVAAGGGDGTVTIWNSTDGKLMHKLPGHKGTVNDVRISPDGSMVLSASTDRTMLLGELPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M3B463</accession>
    <name>M3B463_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein MMF1, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_40589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762693.1">
        <property type="nucleotide sequence ID" value="XM_016908789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B463"/>
    <dbReference type="STRING" id="692275.M3B463"/>
    <dbReference type="GeneID" id="27905926"/>
    <dbReference type="eggNOG" id="KOG2317">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100715_7_2_1"/>
    <dbReference type="OMA" id="GSYFKEP"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000001">
        <property type="entry name" value="L-PSP family endoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00004">
        <property type="entry name" value="Rid family detoxifying hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF58">
        <property type="entry name" value="PROTEIN HMF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF14572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="107" mass="11170" checksum="23B52FF55F8A22D5" modified="2013-05-01" version="1" fragment="single">SQAIHAAGLIFVSGQIPARADGTLVTGSIAEQTTACIEGLVNILEAAGSELAKVTKVTVFITDMANFGEMNTVYEKYFGPYKPARSCVAVKELPKGVPVEVEAIALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M3B598</accession>
    <name>M3B598_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cercosporin MFS transporter CTB4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cercosporin toxin biosynthesis cluster protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_146954</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">MFS transporter; part of the gene cluster that mediates the biosynthesis of cercosporin, a light-activated, non-host-selective toxin. The perylenequinone chromophore of cercosporin absorbs light energy to attain an electronically-activated triplet state and produces active oxygen species such as the hydroxyl radical, superoxide, hydrogen peroxide or singlet oxygen upon reaction with oxygen molecules. These reactive oxygen species cause damage to various cellular components including lipids, proteins and nucleic acids. Responsible for secretion and accumulation of cercosporin, but does not play any roles in self-protection against the toxicity of cercosporin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the major facilitator superfamily. CAR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF14937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763058.1">
        <property type="nucleotide sequence ID" value="XM_016903985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B598"/>
    <dbReference type="STRING" id="692275.M3B598"/>
    <dbReference type="GeneID" id="27901122"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_11_4_1"/>
    <dbReference type="OMA" id="PYYIRKW"/>
    <dbReference type="OrthoDB" id="9986881at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF49">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="485"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="517"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="554"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="149"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="11"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="39"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00053977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00069139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00077167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF14937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="591" mass="64835" checksum="ACD5FAED7D2E922F" modified="2013-05-01" version="1">MPSPRRVADVESTEEELEQEEAEEDEEEEEEEEEEEEVEEKRADRHLPSPDEKGYTSTGTDVDGEKHEQGAEEAAPAEPVRPTRTRSRSRGTSTSHSRFPSQPPLQRLASHLSFRRRRSQPGEAAYQVHFVENDPANPRSWSPRYKTWITMQLGFIALVGSIGSSIISPAEPVIAEYTGVSQEITVFVVALYVLGFAFGPMAWAPISEVYGRRWSILPAIAVLGLFSIGTATSKNAASIFITRFFGGVFGSAPIANVSAALGDMYEPKARGIAITFYAVMVVGGPTLGPIVGAALTNNASLGWRWTEYLLAIYAGFMVILAFFCLPELYSPVILKRKAVQLRNDTGDQRYWHPHEAERMTWSNIFTKYFSRPVRMLVTEPMVACIACYASYVYGILYMTLEVFPIVFREKRGYGAVVSTLPFLGLFVGVLCAVGINLANQSYYGKAVAKNNGRAAPEARLPPMLVGGCLFTIGLFWFGWTADPKYHWSIPTVAAGFIGAGFNTIFQQCINYLVDTYGLYAASAVSANTFLRSLIACGLPLAAKPMFNTLGVGPAASVLGGISCLALPVPLIFMKIGSRLRQKSKFAPTPKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M3B5E7</accession>
    <name>M3B5E7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_146997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF14997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763118.1">
        <property type="nucleotide sequence ID" value="XM_016904016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B5E7"/>
    <dbReference type="GeneID" id="27901153"/>
    <dbReference type="eggNOG" id="ENOG502SBT6">
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    </dbReference>
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    </feature>
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            <begin position="47"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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        </location>
    </feature>
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        </location>
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        </location>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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            <end position="943"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF14997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="963" mass="103683" checksum="2B5E011BBA28894E" modified="2013-05-01" version="1">MRLFDNSAIKIDLFPGKKDRKNAKHKNVGEPKLSREAAPAAYNAVQKVEKEEPRATVKAEPKSNAREEPKANVKEAKGVKEVKSMQNMERPTYQRPNTSRSFHHGSTAVTLVNHAVSANEHDRPHHGSTAATLVNQAASGNEHDRPSIVHSSEQSNPSRTYQQPWSSPTHATSQSVDAHEKQQQRTSPNHSEPSNTTTDHYVYRDTPATESPTSSSSTNERVTRDQRRSRADMQEEWEADQKLRTNILKGAPHSTNHALKNKRSKADMIRATENMARTLSRSPHRSPAGRRQLGGGVDEVRPGTSSSNGSSKFSHASPSRSTTTNRSLSQSRHMNATNSDSTDEAQQKTQHDGLSPSKLPGVAKKQGKAFHSTIRTSPPLSMEPNKTTWSPTSSIPRRNNHSRTRSGQNTTSTSSAGTNTSSGPSHSPPYGNSNGHVQEPGVQHDGSPKQHRDTRSSVDNKKSDHLSIAQRENLATSEYAKHQPQPVINRSNGTWAPPQHDEQTRDVSANTQTSSDAGRGASAGDASQTQQQTHNEPATSSHGVNTNSTTANQQSRDGKSKIRSDISYMNYSRPVTNSSTSTSTPTSQTVNHSRSNTVDSSTSTGMTSKSTQSSREVDFAKPAPPSSSNNRKKPTIKAPRSNYVDSGNSTKSPLQPRFGLGAKSAGNGAAGATTKKEKRTSGLARSQMNANDDHHVVHANNSNGKKFSNGSAVKNNLQNSMRDGSAVAAATGGGGGDLSRMESANSTTTTTTMTSSNKKKPALTLPVATNKNNSNNTSHGNGAGGDGTNSNRAKVVCINSAGKSTVVPTPATANFAGRGSGMMMNGNNNNSNNSRMSGMSNSNGRTSLPRNYVDDEQEEDNYYATPAAQDEQQQQQQKVVSINNGGGGGFSPRNAGTGTGGGRRSTMQQQQQQQQQQQQYEYDEYDEYGNNRKEKDGIERKDSGQSQQNEGDGTVRWDFGVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M3B7P5</accession>
    <name>M3B7P5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cysteine proteinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_37461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016908670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B7P5"/>
    <dbReference type="STRING" id="692275.M3B7P5"/>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1797674_0_0_1"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:protein deubiquitination"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF827">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 34"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="1">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF15872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="144" mass="16414" checksum="B86E0364E2137415" modified="2013-05-01" version="1">MRAQSRPGYTAPAQQRYIRLTSCPDVLVIQLTRTALDLYGNEFKVMTDHDFPEILDLSEYLADPTAQVRYRFSGMVAHHGNEIGAGHYIAGVRGAVEGSGFRLINDSRKVVSTNNFADIQQPIWDKKDRFQPYVLYYTKIRGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M3BQK7</accession>
    <name>M3BQK7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">IkappaB kinase complex, IKAP component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_15526</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ELP1/IKA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756524.1">
        <property type="nucleotide sequence ID" value="XM_016907607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BQK7"/>
    <dbReference type="STRING" id="692275.M3BQK7"/>
    <dbReference type="GeneID" id="27904744"/>
    <dbReference type="eggNOG" id="KOG1920">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001477_0_1_1"/>
    <dbReference type="OMA" id="WRESLYC"/>
    <dbReference type="OrthoDB" id="40048at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056167">
        <property type="entry name" value="A-sol_ELP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056164">
        <property type="entry name" value="Beta-prop_ELP1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056165">
        <property type="entry name" value="Beta-prop_ELP1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006849">
        <property type="entry name" value="Elp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056169">
        <property type="entry name" value="HB_ELP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056166">
        <property type="entry name" value="TPR_ELP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12747">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12747:SF0">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23925">
        <property type="entry name" value="A-sol_ELP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04762">
        <property type="entry name" value="Beta-prop_ELP1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23797">
        <property type="entry name" value="Beta-prop_ELP1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23936">
        <property type="entry name" value="HB_ELP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23878">
        <property type="entry name" value="TPR_ELP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017233">
        <property type="entry name" value="IKAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="ELP1 first N-terminal beta-propeller" evidence="7">
        <location>
            <begin position="1"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 N-terminal second beta-propeller" evidence="8">
        <location>
            <begin position="416"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 alpha-solenoid" evidence="10">
        <location>
            <begin position="691"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 TPR" evidence="9">
        <location>
            <begin position="905"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 three-helical bundle" evidence="11">
        <location>
            <begin position="1075"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1165"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF08403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1253" mass="139277" checksum="505B80CF7C69E61B" modified="2013-05-01" version="1" fragment="single">MRNLRNISHRTLKFLSPGSDSDSSTSPLTATAWDGSNIICAFGPTESDPSIALKRFANSAFAPEDGILVASWDAPPPNPDLPFDRILALHCHPDSGSISLVLEGGDIIVVSEEGSIEIVGSVDAGISAAKWSPDEELLIIATKVDTLLFMTREFEGTASIDLRPEDLQVSSHVDVGWGKKATQFLGPGARAKGLKDPTVPDKVDEGTLSEFDDLKGMKVSISWRGDGEFVAVNSVLEAQTGEGVRKRRVIRVYSREGVLDSVSEPVDGLEGALAWKPSGQLIAGIQRREDQEGRIEVVFFERNGLRHGEFPLRLTPEECKTIGSEIDLDWNSDSSVLAVSMKDRVQLWTMGNYHYYLKQEVLRNGLGKKSVVTNWHSEKPLQLACHSEEGMRLLSYSFEVSRGSVKPPFDHGVVAVIDGRNLKITPLRTANVPPPMAFDEVELPDNAIDVAVDTTGMRIAVLHSDRISVLRCNYGIKPAKKAVILETLHLDTPPGTAGRQLCFNDDDGIVILSSTPNDQGTRISTISDFGTSDMRIETDVASLFRPTNHDRILFEDSKGAIHDLKTKELVGTLPTACPQVEVWQGDDGNLLFGLTPSGMLHIQSGRQKSKIGSCTSFSITHTHLVYTTSNHLLKFVHLHTNGDLEIPLDEPEKDERCRNIERGAKLVTIMPSAYSLVLQMPRGNLETTYPRALVLAGIRHEIGDRQYKKAFLICRTQRVDMNILHDYAPQQFLGDVDLFVKQVKKVEYIDLFLSSLSEEDVSQTIYRETLKAQDSASGVNGMAEHASAHATSKVNKICDAFLKVLGSQESTYLQSIITAHVCKNPPDNPAGLALVSSLRKQGKQEQLEQAVDHICFLADANRLYDTALGTYDLDVTLLVAQQSQKDPREYLPYLQSLQDQEPLRQRFAIDNDLKRFSKALGHLHALEAFDEVKTYATKHDLYSQAIELYRYDNAKLTELMRIYADYLISRNRYKEAGIAYEYIGDSMSAFEAYRSVGALWRECLSCTADMSEEKVFATARDLAEGCEESKDYTSAATIHLEYLQDLPECIRLLCKAYTFSEAIRLIAKHHQPSLLKSVLDPGIIEASATTTELLAEMSTQLHHQIPRLRELRLKKLQDPLSFLDAGETHPDIPDDISLAPTDASTSAGTFMTRYTNKSNLLGSVATDATRKTSKNRKKEERKRARGKKGTVYEEEYLVNSIERLIERLNLSGEEVGKLVEGLMRRSMRERALAVEKGFVEVEEMARACLVEVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M3BV82</accession>
    <name>M3BV82_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha,alpha-trehalase</fullName>
            <ecNumber evidence="3">3.2.1.28</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_88619</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 65 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="3"/>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759360.1">
        <property type="nucleotide sequence ID" value="XM_016910478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BV82"/>
    <dbReference type="STRING" id="692275.M3BV82"/>
    <dbReference type="GeneID" id="27907615"/>
    <dbReference type="eggNOG" id="KOG4125">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006285_4_0_1"/>
    <dbReference type="OMA" id="NHVDAGG"/>
    <dbReference type="OrthoDB" id="200349at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000032">
        <property type="entry name" value="Vacuolar acid trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.40">
        <property type="entry name" value="Glycoside hydrolase, family 65, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.420.10">
        <property type="entry name" value="Maltose phosphorylase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037018">
        <property type="entry name" value="GH65_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005194">
        <property type="entry name" value="Glyco_hydro_65_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005195">
        <property type="entry name" value="Glyco_hydro_65_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005196">
        <property type="entry name" value="Glyco_hydro_65_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11051">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11051:SF8">
        <property type="entry name" value="PROTEIN-GLUCOSYLGALACTOSYLHYDROXYLYSINE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03633">
        <property type="entry name" value="Glyco_hydro_65C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03632">
        <property type="entry name" value="Glyco_hydro_65m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03636">
        <property type="entry name" value="Glyco_hydro_65N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004031443" description="alpha,alpha-trehalase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 65 N-terminal" evidence="10">
        <location>
            <begin position="41"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 65 central catalytic" evidence="8">
        <location>
            <begin position="401"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 65 C-terminal" evidence="9">
        <location>
            <begin position="745"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="919"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="919"/>
            <end position="931"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF11239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1043" mass="113377" checksum="1383844AD38EA1AF" modified="2013-05-01" version="1">MLWPVWAWSAALLFSCHSLAKIYNTRFNGTTWDDEAWSITTTTLDQGHYQSRMSMGNGYLGINLAAVGPFFDVDVQVNGDNIQGWPLFDRRQSFATIAGFWDSQPTTNGTNFGWLNQYGGESVISGIPHWAGLHVKVGEDVLDASVPAEQISSFTSTLDMRNGVLHWNYTWTPTSGSPLDIEYTLLVHKLNVNQAAVQLRLTAAEDLNATVIDLLQGDCAVRSTPVDKGSFAVWPVIWSAVSPDGIRNVTAWVHSALVGDQTCDTASRRIITDSDIVGSNSSSIAQSLDVSLVGGCTSVITKYIGTASSDAFTDPASVALQAAWEGANAGFDELYESHASEWKSILTEDSVEDFRDHDGNLPEDLDVQELQITAITNPFQLLSNTISANAVLAAGNNTKLASNSISVCGLGGSCYAGLVFWDTEVWMQPGLVVTYPDAAKQIAQYRVDKGPQAHENILTAYQSSQNQTDKFSPLGAAYSWTAGRYGNCTGTGPCFDYQYHLNGDIGLEFFNYWAVTGDTDYFRRELFPIYESIAQLYADLVTFNKTTGLYELYNATDPDEYANFQKNVGFTMLLMQSHLNETNTIRERFGLEANQTWANISDLITIPVGEEANIILEYASQNGSITVKQADIVLIDDFLQWPNPYTLSNLDYYAAAQSPDGPAMTYGVFSVVANRESPSGCSSYTYDLYGSQPYTRGPWYQFSEQLIDDWSTNGGTHPAFPFLTGVGGAHRVAVFGYLGLRLMLDTLNIDPSLPPQIPQLAFRTIYWQGWPIKAFSNQTHTTLTRPHHRRGGNPLSTANSTFATAPIPVTISISGTTIHHNLHPNSSLTLSNRQIGLIPTFPGNIAQCRPVVSSPQLFLPGQFPLSAIDGAVSTKWQPVVANVTASITISLPEPFLPIVAIRFDWAKAPPRGYSVTFSNFSSSSSPSNLPSGGQEGQGEEKIVNVTSSSHVQISHPYNSSSADLIRPYASNVTNVTLERPVWSGKFATLEIWGSWANDDGDNGDGDGDGNGGGVGASVAEFAIIAQGSGENVVARSGRGEWLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M3BV97</accession>
    <name>M3BV97_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_68690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759375.1">
        <property type="nucleotide sequence ID" value="XM_016909834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BV97"/>
    <dbReference type="STRING" id="692275.M3BV97"/>
    <dbReference type="GeneID" id="27906971"/>
    <dbReference type="eggNOG" id="ENOG502RXZN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055649_0_0_1"/>
    <dbReference type="OMA" id="WTWEKLV"/>
    <dbReference type="OrthoDB" id="2100128at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39398:SF1">
        <property type="entry name" value="CSN8_PSMD8_EIF3K DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39398">
        <property type="entry name" value="YALI0F14311P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF11254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="305" mass="34395" checksum="927B109098E58B80" modified="2013-05-01" version="1">MSSSSRPPPRRGASGAWNRFKSGGPTDPLDVYGLPSKGEMRLHDHKVQETYYARIVDRYMKFCATCGGSDELGAAFASQSVPETGSTSIVGNGGSKKPPLSHRPSDAARSSDLPNILLAMRKLREGILGSRRRDHFAQRTYMFIIHTSILSKSWESYLPALQYLLGTIHKYTPLSVPEQQEFSSYHILDLACRQNELLDAFAARLTFKNRDRRVATALQAIVHDDWVKYWRTRRAVDGYQRAILEFAVDRMRLHALKCLGRGYLSADKAYVERSGDQSWEELVKDGVGWQLQETGSVIIKKPKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M3BVD1</accession>
    <name>M3BVD1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Acyl-CoA dehydrogenase NM domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_150256</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759410.1">
        <property type="nucleotide sequence ID" value="XM_016906052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BVD1"/>
    <dbReference type="STRING" id="692275.M3BVD1"/>
    <dbReference type="GeneID" id="27903189"/>
    <dbReference type="eggNOG" id="KOG1469">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_1_2_1"/>
    <dbReference type="OMA" id="LAYMYAM"/>
    <dbReference type="OrthoDB" id="434771at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF13">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0274">FAD</keyword>
    <keyword evidence="4 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="11">
        <location>
            <begin position="63"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="10">
        <location>
            <begin position="171"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="9">
        <location>
            <begin position="284"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF11289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="485" mass="53195" checksum="5E26D9EE97D6564D" modified="2013-05-01" version="1">MSNAPPLPTANAGPRPSASGRVPPIAKPFVSERAAKYLDIIEKWVNEECIPADQVYATQIGTGDARWDGHPSILDDLKEQARKLGLWNMFLPKNHYANLSEYDRYGGAGGFTNVEYGLMAELLGRSKIASEACNCAAPDTGNMEVIARYGTADQKKTWLAPLLAGEIRSGFLMTEPDKASSDGSNISLSIRKEGSELILNGSKWWSSGAGDDRCKIYVVMGLSDPDNQDRYGRQSMVLVPSDAKGLVVHRMLSVYGYDDAPHGHGHITFDNVRVPVSNLLLGFGKGNEIMQGRLGPGRIHHAMRAIGSAEVALEWMIARLNDDRKVPFGKPLREHGVLLEWVAKSRLEIDSARLIVLNAAIKIDQGDAKAALVEIAQAKILVPTMACTVIDRAVQAHGAMGVCQDTPLANMWAHIRTIRIADGPDEVHLNQMGRRENRARARECIERLQAQEKRAQELFNKHGVEDKQLGGRKVKGVQGMTRSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M3BY29</accession>
    <name>M3BY29_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">S-adenosylmethionine synthase</fullName>
            <ecNumber evidence="11">2.5.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SEPMUDRAFT_66528</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of S-adenosylmethionine from methionine and ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-methionine + ATP + H2O = S-adenosyl-L-methionine + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="11">Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AdoMet synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="11"/>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761087.1">
        <property type="nucleotide sequence ID" value="XM_016909753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BY29"/>
    <dbReference type="STRING" id="692275.M3BY29"/>
    <dbReference type="GeneID" id="27906890"/>
    <dbReference type="eggNOG" id="KOG1506">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041802_1_1_1"/>
    <dbReference type="OMA" id="ASYMARY"/>
    <dbReference type="OrthoDB" id="5852090at2759"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006555">
        <property type="term" value="P:methionine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18079">
        <property type="entry name" value="S-AdoMet_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000001">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000003">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000004">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="S-adenosylmethionine synthetase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-adenosylmethionine synthetase N-terminal" evidence="13">
        <location>
            <begin position="17"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase central" evidence="14">
        <location>
            <begin position="129"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase C-terminal" evidence="15">
        <location>
            <begin position="251"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMF12966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="394" mass="43165" checksum="C37BB2E3E2205A30" modified="2013-05-01" version="1">MATNGTRPHSGPAKGTFLFTSESVGRGHPDKIADQVSDAVLDACLAEDPASKVACETATKTGMVMVFGEITTKTRLDYQKVIREAIKDIGYDDSSKGFDYKTCNVLVAIEEQSPDIAQGLHYEEVLEKLGAGDQGIMFGYATDETPELLPLTVLLAHKLNSTMEEARKSGELPWLRPDTKTQVTVEYEHDNGAVIPKRVDTVVVSAQHAETITTEDLRSEIKEKIIKKAIPAHLLDDKTVYHIQPSGLFIIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYSKVDRSAAYLARWVAKSIVKAGLARRALVQFSYAIGVAEPLSIFVETYGTSDKTSEELVQIVRNNFDMRPGVIVKDLDLAKPIYRETAKNGHFTNQNFSWEKPRELKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>M3BZA4</accession>
    <name>M3BZA4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_155708</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761512.1">
        <property type="nucleotide sequence ID" value="XM_016907634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BZA4"/>
    <dbReference type="GeneID" id="27904771"/>
    <dbReference type="HOGENOM" id="CLU_2741665_0_0_1"/>
    <dbReference type="OrthoDB" id="2119945at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF13391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="71" mass="7902" checksum="56417B92668F6351" modified="2013-05-01" version="1">MVLSPLLSRPLISWYSHRIYSANEAANLVDMQLRCCSVRRPAMPQKQLSCESQSQALQDSQPLLAVGSLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M3C1P4</accession>
    <name>M3C1P4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NUDIX family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_82292</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762352.1">
        <property type="nucleotide sequence ID" value="XM_016910304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C1P4"/>
    <dbReference type="STRING" id="692275.M3C1P4"/>
    <dbReference type="GeneID" id="27907441"/>
    <dbReference type="eggNOG" id="KOG3904">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018689_0_0_1"/>
    <dbReference type="OMA" id="IIMFPPQ"/>
    <dbReference type="OrthoDB" id="1695362at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18870">
        <property type="entry name" value="NUDIX_AcylCoAdiphos_Nudt19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039121">
        <property type="entry name" value="NUDT19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12318:SF0">
        <property type="entry name" value="ACYL-COENZYME A DIPHOSPHATASE NUDT19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12318">
        <property type="entry name" value="TESTOSTERONE-REGULATED PROTEIN RP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="8">
        <location>
            <begin position="30"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="188"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="71"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF14231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="366" mass="40633" checksum="F8F3750D12F7D812" modified="2013-05-01" version="1">MSSKPKEPRAATSVKSYSTTPPKDKKEPAVPRPSSSVLLISPNNQVLLLQRVKQSSSFPSAHVFPGGNVSELHDGKAPEPSHPQRHEDSEMYRMAAIRETFEESGILLARNNGFGRLIEVPQDQREEGRKLVHGNQIPFTKWLAQKGGRADIDGLTPFTRWITPTNVPKRFTTQMYLYFLPTLSSTPISEGSGNPDDSEAEVDIPSPTTDGGKEHTTARFLPASAWLRLAQEGRIIMFPPQFFLLHQVAQFLDGLKSPTDYASISREEVPREELELRRKRLLEFAKSGDPSYVDACISPTTMPPPYGKKREDGRQVLALNRAGPELQGTARKGPNDQCVLVDFKREGPRRLAVISRAEALGSDAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M3C4I9</accession>
    <name>M3C4I9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_10649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">SO2202</strain>
        </source>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47611:SF1">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47611">
        <property type="entry name" value="HAT DIMERISATION DOMAIN, C-TERMINAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="4"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF15211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="59" mass="6773" checksum="D65CB153385C4CA5" modified="2013-05-01" version="1" fragment="single">YYSNRIKRPILYTIARDYLAISTTSVPSESEFSKANNIVTQKRNKLLPDTIKKLAILKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>M3C686</accession>
    <name>M3C686_SPHMS</name>
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        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_124001</name>
    </gene>
    <organism evidence="7 8">
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        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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    <dbReference type="GeneID" id="27899010"/>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_440068_0_0_1"/>
    <dbReference type="OMA" id="AHWRIAY"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="53"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="109"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="163"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="669"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="113"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="669"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMF15786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="693" mass="75091" checksum="695DCA507ED7F8AE" modified="2013-05-01" version="1">MLSMFHDDPSSSTIRMPGIVKLQPAVMPSSSSSSSSPSSSLGDKMQRKRAARACDQCRRRKSRCDGLMNCSACSTIGLQCSFGHQVKQSRGPAYIAHLEQKIEALQDRLRHSSCGSEQSNNDTDETMTTQTSPSLSNPDRLSIGSRERLSTISADSYSSSSSFLKHHLTGGSSSSSSGGGGGGSDSSSGTTKKMASMRRTDTMMASSSSSVDEMMMMPTKYIETITTEPRGKPFGFDILRQLINFINHTGTAPTLPQDSSLKVVQALDSSHSIDNLLAGPMSSNTLLPPAKDEALKLVEIAFGEAFHLWPFVERSQIETTIYRLYDTNTFGRDFGDKEELGLVYSVLALGQRFDHSTTVLAETRRVQGIAYFAAAQELVPLSHCDRNLSAIQTVLCLALFLKAASALGRTHSYLAAAASAALRLGLHEDTPGFPKDESVLRRRVWSALNVFDAYTSIALGVPRTVGFECDEQDFYPSMSSMGSESGLVASNEHMEMMCTLSRGITAVHNTATARRSAGLGAYSISQQAIQEAGAELEEWARNCPLPLQAADHMTRSQLYLAYAYDYAQLLLYSPFAHYLTMPTVEINSPPYTLGLKAVNAALHAIQVAELLHKQLRLDEAYFLTVDVLVIAATTLLVFELGSGRESPWVHEALHASGIAKGLGHTNTCEENQSARNHSDATTFRPSAGDAPPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M3C6W2</accession>
    <name>M3C6W2_SPHMS</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_147687</name>
    </gene>
    <organism evidence="2 3">
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        <name type="synonym">Septoria musiva</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF15971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="138" mass="15832" checksum="BE421EA2641EE10A" modified="2013-05-01" version="1">MSSHTQDPDPDSEHQRLRLSTETERTLVEDHVDTTTHPTPRAASPTRTLVDASDSPYRGFPSKAHYLAALHEWAEEKRYLSAGTTTVEGFYGNTTLESYASRPKHELGIRRRLREIMEKKKKHTKRSSSWPESLRRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M3C765</accession>
    <name>M3C765_SPHMS</name>
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        <recommendedName>
            <fullName evidence="8">Chitin-binding type-4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_147759</name>
    </gene>
    <organism evidence="9 10">
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            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the polysaccharide monooxygenase AA13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF16096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764217.1">
        <property type="nucleotide sequence ID" value="XM_016904509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C765"/>
    <dbReference type="GeneID" id="27901646"/>
    <dbReference type="eggNOG" id="ENOG502QQKA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053021_2_0_1"/>
    <dbReference type="OMA" id="SCIDFTM"/>
    <dbReference type="OrthoDB" id="120613at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004302">
        <property type="entry name" value="Cellulose/chitin-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052282">
        <property type="entry name" value="Starch-active_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36575">
        <property type="entry name" value="BINDING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36575:SF2">
        <property type="entry name" value="CHITIN-BINDING TYPE-4 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03067">
        <property type="entry name" value="LPMO_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032207" description="Chitin-binding type-4 domain-containing protein" evidence="7">
        <location>
            <begin position="17"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-4" evidence="8">
        <location>
            <begin position="17"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF16096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="210" mass="22483" checksum="08A54D00D0D638A9" modified="2013-05-01" version="1">MKYLAACLTILELVSAHGYFEAPLGRKPGNAFSAACGAQANSMMSSDINGNIQGLQNLVASQSDYDPTKCDFWTCKGMKFEDNTDSVQTYTAGQQVPLYFNIRAPHSGYANVSIIDTTSNSMIAANLSAWDEYALTSIPAKTEWTNFTITIPSDIGTQCSTAGKCAIQMHWNAPPPVDQTYQSCIDFTVGASGGSNASSKKRNVAKSFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M3C8M0</accession>
    <name>M3C8M0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_121723</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF08235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756356.1">
        <property type="nucleotide sequence ID" value="XM_016901708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C8M0"/>
    <dbReference type="STRING" id="692275.M3C8M0"/>
    <dbReference type="GeneID" id="27898845"/>
    <dbReference type="HOGENOM" id="CLU_042941_2_0_1"/>
    <dbReference type="OMA" id="WHRIIND"/>
    <dbReference type="OrthoDB" id="3637778at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF4">
        <property type="entry name" value="CYCLOCHLOROTINE BIOSYNTHESIS PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF08235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="266" mass="29936" checksum="D24C973DA391C333" modified="2013-05-01" version="1">MDFESSDEEGKPLVPSFPETLRSSRHGSLRRQCSTVLLVLLFANVLLMLITAICLYLLATTTGLVNQGQRIDCFDDTLLNPPIVWEQRTFNSTVDIAKDAVTDSFEPVSPTTSADWGRVLDVGEIRISLEEAARLPSETAPLYGGEEGYAGVLEVFHQLHCLNRIRKKFYNLTVHDDSTDSEHLNTSHDKHCFDYLWQTLLCHADVSVMSVGWNDKQKAFNANFAVTKQCRNFNVIHNWAKNREAKLPPPGDTHPGRIESEDGMNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M3CAE9</accession>
    <name>M3CAE9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_151745</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756946.1">
        <property type="nucleotide sequence ID" value="XM_016907016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CAE9"/>
    <dbReference type="STRING" id="692275.M3CAE9"/>
    <dbReference type="GeneID" id="27904153"/>
    <dbReference type="eggNOG" id="KOG4157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024893_0_1_1"/>
    <dbReference type="OMA" id="MTSIGCF"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051836">
        <property type="entry name" value="Kremen_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269">
        <property type="entry name" value="KREMEN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269:SF16">
        <property type="entry name" value="PROTEIN SLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004031849" description="WSC domain-containing protein" evidence="9">
        <location>
            <begin position="29"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="10">
        <location>
            <begin position="47"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="141"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="250"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF08825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="318" mass="32941" checksum="DAA65B13D81075C8" modified="2013-05-01" version="1">MRCTPRLPSVNVARTIILLSLLTTAAMPQISQPRRDIIPGQLQKRANAVYKGCYSSAASMSSVGTYMYQSSGYCSTQCANQDSPAMALTSGNDCYCGDELPADSDKVDDSKCNSPCTGYGQTNCGGDGVFGVYLTNGDSGVPVAGGSDSSSSSSSATSTTREPESEPPTKASATPSVVTNVSPGQTLVVTITPTPRPSASSTSTTSSSGGGGGGSNTAGIAAGVVVGVLAIAGLVAGLFFWMRQKKRKEAESEYAKRTQVSDFMRGAHERKPPSTGYSHMSDTRLDPEAGAHRNSVGSLADNQDYSRRILRVANPDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>M3CB83</accession>
    <name>M3CB83_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_151937</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF09105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757226.1">
        <property type="nucleotide sequence ID" value="XM_016907137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CB83"/>
    <dbReference type="STRING" id="692275.M3CB83"/>
    <dbReference type="GeneID" id="27904274"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003487_0_1_1"/>
    <dbReference type="OMA" id="RSPWLWE"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF8">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="91"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="122"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="124"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="146"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF09105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="889" mass="99364" checksum="59D233E606EEB513" modified="2013-05-01" version="1">MAAEPAPTQTQTQQPEQSSPSESRHRCYLCSRTYERHDHLSRHLKSHDNERAYRCTECGKGFNRADLLNRHRAAHSKTSAGDVFRKRTPRACEACIKAKTKCDDDRPCKRCKSRDMTCVDSDARSTSQEHASSTSQPESHSSSISSGGGGGGGGGGGGVAQIPTPASMPHALEDNNNSLPSASLVNQFPIGQDVFTDPLGMECYGFPDSSFFESIMMPDMANMAQVQIQMPPDVSDFTQDFDLSGVDFDFGFLKSGLTRPSTPYETADDSSVTTSTDPHGDARLRSEAFKKSPWSWSHWIPERNHGCFTGQEEINVQQDAIETHDQHVSPSVRRSVHCELDHEARDRMIRVVTKVAYSKVSMPSFPSLQLLEDLIDVSLLQDSNAVDAYVHASSFSARHTRTELLMAMVAAGARYVALPPVWKMGLIIQEVVRLAMAEVFEADNSATRDIQSLQTYMLWLDIGIWSGFRRKTEIASSFLQPAATMLTWASAFTRSRYQDIIPYPEDDDEALDQKWRSWIEQEGLKRLVLHTFLHDSQVATTHLKNRLVSPAQMMLPAPMTLDLWLAPNSQAWRNIWIARQPPSQSAMPSMMEIFGNLGQLDALGNVVDKPLCTLAACHALAHEVWQCRQQAVLLASWQAQGRRDRWLAYQHRQRDLLDDLMTVHAFCETQQSVAPEILFTIEFLIMSLHVSLEDILLFSGKSGEEEARKVYPRIRTWTQDSEARIAVWHAGQVLRVARTFEQTRLRDFYAVAVYQATLTLWVYGMVTSNTARKSGEPTPMPGVQPSTDTSHDMLAPVNRVFLDDDNDKAAKSFKLIGQGEAGLRNRHGPQEGASWNEAMNFCSLHNSKGVMFISGDILKNNFPKSRNGLPPLVENLVNLISELGKLSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M3CC17</accession>
    <name>M3CC17_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_151036</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP17 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF09947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758068.1">
        <property type="nucleotide sequence ID" value="XM_016906555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CC17"/>
    <dbReference type="STRING" id="692275.M3CC17"/>
    <dbReference type="GeneID" id="27903692"/>
    <dbReference type="eggNOG" id="KOG4709">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067149_1_1_1"/>
    <dbReference type="OMA" id="EWDGFPD"/>
    <dbReference type="OrthoDB" id="3649242at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019186">
        <property type="entry name" value="Nucleolar_protein_12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14577">
        <property type="entry name" value="NUCLEOLAR PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14577:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09805">
        <property type="entry name" value="Nop25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="38"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="90"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="180"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="43"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="98"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF09947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="233" mass="26725" checksum="8441E61F6E6473C4" modified="2013-05-01" version="1">MGPPAKRRKIDVIRRQKPVEELTFSIDARQEYLTGFSKRKAARREQAREQAIKEAKEEKIRERKELRDQRKADLETHVAEVNKVLREQKALAIGKDPDEVDSDASDEFGGFDDDKNNSSSITGEGEPLPDDAEYVDEDKYTTVTVEAMDESEDEEEVAAKKAAEKAHYAKIEEEKAAELAAKRKKRPWLKDGAEKPKKKKFRYESKAERSLTRQKQKSKSSKAAKERRGKSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M3CE59</accession>
    <name>M3CE59_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_68838</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759452.1">
        <property type="nucleotide sequence ID" value="XM_016909842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CE59"/>
    <dbReference type="GeneID" id="27906979"/>
    <dbReference type="eggNOG" id="ENOG502RA14">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053559_0_0_1"/>
    <dbReference type="OMA" id="MFAMYLD"/>
    <dbReference type="OrthoDB" id="2139939at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044688">
        <property type="entry name" value="SCI-1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34117">
        <property type="entry name" value="STYLE CELL-CYCLE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34117:SF1">
        <property type="entry name" value="STYLE CELL-CYCLE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF11331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="290" mass="34553" checksum="6F6E95F7AD22B731" modified="2013-05-01" version="1">MSSASVPVEYSKKRSRSPHSHHHRSEDVKRHRSRSPHRKPHHHHHHHHHHRRRHEPRDVPTSLPLNAQPLHKSQFQHYEGLFARYLDVQKLINIDDLSETEVRGRWKSFVGKWNRGELAEGWYDAEARWRAEDRVLGAAIPNLQDLQHRNELVEEAHLHDRANLLHERKLDRNLQKERVEELVPRADPGSRERQMEKKADKTFTLHQFREAKDGGDVEVGEQELMGGGDGEQEFQREVKQRQRAKSEREIRKEEALRARMAEREERMRGVRMKEEKTMEMLRNIAKTRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M3CHK9</accession>
    <name>M3CHK9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_148628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761394.1">
        <property type="nucleotide sequence ID" value="XM_016905040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CHK9"/>
    <dbReference type="STRING" id="692275.M3CHK9"/>
    <dbReference type="GeneID" id="27902177"/>
    <dbReference type="eggNOG" id="ENOG502S2D0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016396_0_0_1"/>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12432">
        <property type="entry name" value="RRM_ACINU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034257">
        <property type="entry name" value="Acinus_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47031">
        <property type="entry name" value="SAP DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47031:SF3">
        <property type="entry name" value="SAP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF13273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="452" mass="49698" checksum="67A1DF12FF60DF9F" modified="2013-05-01" version="1">MTDYDKLKVTDLKDLVKERGIATTGLKLKQQFVDALNADDSSNNGAEVIERAEESNGNGNGNGDAKDEDAGEDVQEEDNSNKRKRRSPTPPVSEESVSKKLKTADDAPSVQLPEDVAADAPAAVDEAAAKTIQPYGSSDDIMQVDNAEGEDEVMEDITARLAKHPATRALYIRELVRPLQPNSLREHLRTVASPPGATSASAAEIVETFHLDKLRTHALVVFDSTSAASRARNALHDHIWPDEPSMRKPLWVDFVPEDKVSEWIEMETERPDTKWEVTYDGVDTNGQTTAILQEVGSEHQTPAPAAPNPQRSSQSQDPPAPQKEPPPQSKSFDTLDSRYKFTQCKPKIYYQPVAPELADSRQENISTETSREWEDKLSDPSLYGEGELRRYTFEDGDKLVDGGADFGLFGRKSTRGGRGGGEYRGGGRGRGRGEYRGGDYYRGGGSGGRRQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M3CHV3</accession>
    <name>M3CHV3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Catalase</fullName>
            <ecNumber evidence="13">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SEPMUDRAFT_148691</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 14">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Alkaloid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the catalase family.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="13"/>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761484.1">
        <property type="nucleotide sequence ID" value="XM_016905085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CHV3"/>
    <dbReference type="STRING" id="692275.M3CHV3"/>
    <dbReference type="GeneID" id="27902222"/>
    <dbReference type="eggNOG" id="KOG0047">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010645_2_1_1"/>
    <dbReference type="OMA" id="FYNQGAR"/>
    <dbReference type="OrthoDB" id="6880011at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009820">
        <property type="term" value="P:alkaloid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08157">
        <property type="entry name" value="catalase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.180.10:FF:000001">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024711">
        <property type="entry name" value="Catalase_clade1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465:SF62">
        <property type="entry name" value="CATALASE T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038928">
        <property type="entry name" value="Catalase_clade1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0017">Alkaloid metabolism</keyword>
    <keyword evidence="5 12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 13" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="8 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 13" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="16">
        <location>
            <begin position="46"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="547"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMF13363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="577" mass="64870" checksum="8E47DB6B1EA7FDCC" modified="2013-05-01" version="1">MLATSLHDTNMAPSATNGGPDGRLTGDIHRDYNDDRNASSEDTLYCTSNGVPIAHPYETQRVGENGPLLLQDFHLIDLLSHFDRERIPERVVHAKGGGAHGYYQTTDPMEDLCEADLFKAGKKCPVTVRFSTVGGESGSHDCARDPRGFSVKFRTEEGNWDMVANNTPVFFLRDPAKFPHFIHTQKRDPSTHLTHADDSTMFWDYLSQNPESIHQVMILMGDRGIPDGWRKMHGYAGHTLKLVNKKGDWVYGQMHMKSKQGTGFITQADSANYSPDYAQKDLYDAIEKGDYPGWDVCWQTMTPKQAEDLWENEKINIFDLTHVWPHDKFPLRKVGEFHLNENVKNYFAEIEQIAFNPAHLPPGIEPSADPVLQSRLFSYPDTHRHRIGVNYQQLPVNAPRVPYRIANFQRDGNMAFYNQGARPAYLSSIQPVAFRERTVDLDKTHGHFTGNAVTFLSEIRPEDFNAPRALWQKVFDEDAKARFVENVSGHMGNCHKEEIIKRQLAIFREVSPDLAERLEKATGVKGYEGIAGLTFNGTHNGMANSSKNRAANGMSDKTVSLANNGGPTAGTHQKITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M3CIQ2</accession>
    <name>M3CIQ2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_148903</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761809.1">
        <property type="nucleotide sequence ID" value="XM_016905219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CIQ2"/>
    <dbReference type="STRING" id="692275.M3CIQ2"/>
    <dbReference type="GeneID" id="27902356"/>
    <dbReference type="eggNOG" id="KOG0199">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006696_0_0_1"/>
    <dbReference type="OMA" id="IRIYEAI"/>
    <dbReference type="OrthoDB" id="635774at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27001">
        <property type="entry name" value="OS01G0253100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27001:SF931">
        <property type="entry name" value="OS11G0664100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="351"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="44"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="164"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="588"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="675"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="796"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="105"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="195"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="588"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="607"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="680"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="735"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="796"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="824"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="851"/>
            <end position="863"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF13688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="863" mass="97337" checksum="552D19C5AE12E934" modified="2013-05-01" version="1">MPQRFPFASHTNDHAALPEMGSEDLVQPKRLRRSSLLRKPLSLWRKHHADSTDEALPETAPAELEADGGGTQWEEPEQRRPSLPDEVLPICKRAIPSLPRPQTFRRQESERRERLLEVEPTTKERRARSEDMRRTSAASRRALSPTPLPVSRFSALDIPEFRQEGNLSPASGAAADLHDPDTAHNPSNIPASRIPEVDTDHRPAVDDDRPPQGDSSDQATWAEEYDRRWILNLSMQFRDKSNREKFFVTYAETSTQWRRLTVSLDYRDAPPNSLEADLSILHYQRDKSLRIYEAIRDSLPDIQYYDTVTNLKLETTADDGQLHVHVREDANEIVNWPNISLFDHIQCPRFNETSLEFDSHLSGFVYKVRLNGRVVIKKEIPGPDTVDEFLYEVNALDSLLDSKHVVQLEGLVTDDRGELVKGLLISYAGQGALVDMIYDLRGTTALPWHRREKWAHQIVGGLADIHEAGFVQGDFTLSNIVIDEDDNAQIIDINRRGCPVGWEPPELNKLIDSGQRVSMSIGVKTDLFQLGMVLWALAEEVDEPERVQRPFPAIVDEVPHYFRDIVDMCLSERPQGRKGAVYLLQRFPTSAGQPPSRSASKDYELNSPLSDRSLSSSAHRSAKKYIDPDMAVTIDDVKEGRRLDTNDYSSLFHDAVTYMQPDSNPASMYAFESEGSCVVGRRRRTHSRGRSPVSSRRRRSSPYGRTASSATSYEASLPHRRLSRYGDDCSGSDGEQQHGCKDPDWGTYGAAEPREFEHMSPMARRIAEMQMGEASRATGLLHMDSGFDEVMEDHELGMSDVTERKDEPATPRPSSIQDAPTPGPYYTPGATPTSLAHGKDDERIIVALDSENSHENDGRDTRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M3CIR2</accession>
    <name>M3CIR2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Rhamnose mutarotase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_116721</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761819.1">
        <property type="nucleotide sequence ID" value="XM_016901279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CIR2"/>
    <dbReference type="STRING" id="692275.M3CIR2"/>
    <dbReference type="GeneID" id="27898416"/>
    <dbReference type="eggNOG" id="ENOG502S4QF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100689_1_0_1"/>
    <dbReference type="OMA" id="HAKVWPE"/>
    <dbReference type="OrthoDB" id="9981546at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016857">
        <property type="term" value="F:racemase and epimerase activity, acting on carbohydrates and derivatives"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008000">
        <property type="entry name" value="Rham/fucose_mutarotase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34389">
        <property type="entry name" value="L-RHAMNOSE MUTAROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34389:SF2">
        <property type="entry name" value="L-RHAMNOSE MUTAROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05336">
        <property type="entry name" value="rhaM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF13698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="118" mass="13806" checksum="1E9D0D45F568EDE7" modified="2013-05-01" version="1">MSPEPRRIAQIVRLKRESLQAYKECHDAVWPAVLQQIKDCNIVDYSIFLDDQSMTLFATMKYVGDDYDADMEKMKANPKVREWWQMTDGMQETLVDGAQGSTDPKGWWKPLEEVFRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M3CJP6</accession>
    <name>M3CJP6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_147890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762164.1">
        <property type="nucleotide sequence ID" value="XM_016904579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CJP6"/>
    <dbReference type="GeneID" id="27901716"/>
    <dbReference type="eggNOG" id="KOG1196">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_29_1_1"/>
    <dbReference type="OMA" id="WMSDIPQ"/>
    <dbReference type="OrthoDB" id="809632at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05288">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000121">
        <property type="entry name" value="Prostaglandin reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF7">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="74"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF14043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="350" mass="38227" checksum="0E71A81B1DF5F16D" modified="2013-05-01" version="1">MVQNKAFIFANPPQGWPVPGKDIKTESSDFDVDQQPPQGGFTIKLHYASFDPYQRGRMRAADVKSYSPPFDLGKPITNAAIATVIKSDNAKFPAGQVLVGARTYTQEYAAITAEEAVGFKVLDNPYNLDVKYFLGPLGMPGLTAYSSFYEIGQPKKGETIFISAASGAVGQLVGQLAKHEGLKVIGSVGSDDKLNFITKDLQFDGGFNYKKEKPLDALKRLAPDGIDIYYENVGGEQLDAALMHANTFARIVACGMVSQYNLSPDQAYGVKSMMQVVAKRIKMQGFIVTDENMGPRYSEDHQKNVQKWLHEGTFKASIHVTEGIDNAAEGFVGMLKGENFGKAVLEISKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>M3CL04</accession>
    <name>M3CL04_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">T-complex protein 1 subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_148161</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762579.1">
        <property type="nucleotide sequence ID" value="XM_016904748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CL04"/>
    <dbReference type="STRING" id="692275.M3CL04"/>
    <dbReference type="GeneID" id="27901885"/>
    <dbReference type="eggNOG" id="KOG0364">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008891_7_3_1"/>
    <dbReference type="OMA" id="CGGSTIR"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03337">
        <property type="entry name" value="TCP1_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000037">
        <property type="entry name" value="T-complex protein 1 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000005">
        <property type="entry name" value="T-complex protein 1 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012719">
        <property type="entry name" value="Chap_CCT_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02344">
        <property type="entry name" value="chap_CCT_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF14458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="537" mass="58787" checksum="72A088EDF4D70FB8" modified="2013-05-01" version="1">MQAPVVVMNTATGDRKTGRQAQLSNITAAKTVADIIRSCLGPKAMLKMLLDPMGGIVLTNDGHAILREIEVAHPAAKSMIELARTQDEEVGDGTTTVIILAGEMLALSLPQLERNIHPVVIIQAYKRALADCLKVIQDVSIPVDINDNDVMRNLISTSIGTKFTSRYSDLMCDLALQAVRTVSTDAHGGKREVDIKRYARVEKVPGGEIEDSKVLDGVMLNKDITHPKMRRRIENPRVVLLDCTLEYKKGESQTNIEISKEEDWNRILQLEEEQVKAMCDAILAVKPDLVITEKGVSDLAQHFFQKANITAIRRVRKTDNNRVARATGATIVNSVYDLTERDVGTQCGLFEIEKIGDEYFTFLTKCKDPKACTILLRGPSKDILNEIDRNLLDAMSVARNVIFHPYLSPGGGATEMACAVRLSQLAKSIEGVQQWPYKAIAESMEVIPRTLIQNAGASPIRILTALRAKHAEGGSTWGIDGDAGKVVDQKDFGIWEPQAIKLQSVKTAIESACLLLRVDDIVGAKQARTAGGQGGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M3CRA4</accession>
    <name>M3CRA4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Flavin prenyltransferase PAD1, mitochondrial</fullName>
            <ecNumber evidence="6">2.5.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">PAD1</name>
        <name evidence="10" type="ORF">SEPMUDRAFT_124266</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for the ferulic acid decarboxylase FDC1. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dimethylallyl phosphate + FMNH2 = prenylated FMNH2 + phosphate</text>
            <dbReference type="Rhea" id="RHEA:37743"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:87467"/>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
            <dbReference type="EC" id="2.5.1.129"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Oligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the UbiX/PAD1 family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.129" evidence="6"/>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF16193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764314.1">
        <property type="nucleotide sequence ID" value="XM_016901904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CRA4"/>
    <dbReference type="STRING" id="692275.M3CRA4"/>
    <dbReference type="GeneID" id="27899041"/>
    <dbReference type="eggNOG" id="ENOG502QWR5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074522_0_1_1"/>
    <dbReference type="OMA" id="FVHERYL"/>
    <dbReference type="OrthoDB" id="5126881at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106141">
        <property type="term" value="F:flavin prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1950:FF:000001">
        <property type="entry name" value="Flavin prenyltransferase UbiX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="entry name" value="Flavin prenyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01984">
        <property type="entry name" value="ubiX_pad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004507">
        <property type="entry name" value="UbiX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004685">
        <property type="entry name" value="PRK06029.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00421">
        <property type="entry name" value="ubiX_pad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374">
        <property type="entry name" value="FLAVIN PRENYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374:SF1">
        <property type="entry name" value="FLAVIN PRENYLTRANSFERASE PAD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="Homo-oligomeric flavin-containing Cys decarboxylases, HFCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 6" id="KW-0288">FMN</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1 6" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="Flavoprotein" evidence="9">
        <location>
            <begin position="27"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="34"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="111"/>
            <end position="114"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>dimethylallyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>dimethylallyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00060793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF16193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="213" mass="23464" checksum="2B88BAE63230C3F4" modified="2013-05-01" version="1">MVNAQETNGTTNGHTNGYSDQQTARQRIVVAMTGATGAILGIKLLIALRRLNVETHLVLSHWAEATIRYETDYTPAAVRALADHSYSNRDQAAPISSGSFRADGMIVVPCSMKTLAAINAGYCDDLISRAADVVIKERRRLVLNVRETPLSEIHLRNMLGVTHAGAIICPTVPAFYTKPESIEQLVEQMVGRTLDLFGFDTKDFPRWSGYEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M3CVQ4</accession>
    <name>M3CVQ4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidase signature enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_136997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF08222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756343.1">
        <property type="nucleotide sequence ID" value="XM_016902820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CVQ4"/>
    <dbReference type="STRING" id="692275.M3CVQ4"/>
    <dbReference type="GeneID" id="27899957"/>
    <dbReference type="eggNOG" id="KOG1211">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_18_1_1"/>
    <dbReference type="OMA" id="NHTVWRT"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF170">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="87"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF08222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="539" mass="56923" checksum="6E6F87F11DBB7DDD" modified="2013-05-01" version="1">MSVVTLPNGTSNLSKEEVITLASSAGLKLKEAHLSDWAALLGSLDPIVNKYLEAEDYTLQPDLTKYPRTNISIPSTAEESDQGGWATKVTVSATSPTSDLLKGKTVAIKDNIALAGVRCTNGTEAVTWTPQIDAPIVTRILDAGGIINGKAACENGCMEGISDTSCTGNVHNPFAPGYSCGGSSSGSGRVVASGQAEMSIGCDQGGSIRIPASMCGLVGLKPTWGLVPYTGILSLEGTIDHAGPIAKTVRDCAVLLEAIAGPDGIDDRQPAYFPEKSLEFTLGLDEFVAAAAGKEKPLAGVKVGVLEEGYQIHGMCDSVSTLCKAAVEHLATLGAEIKSVSIPLHLSAAEIWMISLPLSGTKTALLGVTEGRKTLHMLDRAPVEKLSDEQFQKLGPGAQNLYMRYLYMKEKWGAQVHAKSHNLLRKINDAYDAVLADVDVLIMPTLPSPACKLFDQPNEHGPLERMSRNVGMVGNTAPFNSTGHPALTVPVGFVPALEDESVKLPAGLQIVGRKFKDLDCLKVGAAWESSVDWKTFGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M3CX73</accession>
    <name>M3CX73_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_151972</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756392.1">
        <property type="nucleotide sequence ID" value="XM_016907162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CX73"/>
    <dbReference type="GeneID" id="27904299"/>
    <dbReference type="HOGENOM" id="CLU_1603774_0_0_1"/>
    <dbReference type="OrthoDB" id="3478218at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF08271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="166" mass="17200" checksum="52820211B144568F" modified="2013-05-01" version="1">MRFSVVATAAFAGAAIAAPAAQPVAENEKRLAGFVAFGLGSLATWAAGKFGLIPRDLTLAEGDVPYEKAAELFAEDAVDFLSKKAKPSEATVCIDVPYTVADESKAHDVGGFDFEGLGNQTIFDCFVLSGPNTMTVDLEQGKTTPDSVAVRAGPGVWNATTGVLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M3CXE2</accession>
    <name>M3CXE2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Translation initiation factor IF-2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SEPMUDRAFT_53456</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756898.1">
        <property type="nucleotide sequence ID" value="XM_016909265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CXE2"/>
    <dbReference type="STRING" id="692275.M3CXE2"/>
    <dbReference type="GeneID" id="27906402"/>
    <dbReference type="eggNOG" id="KOG1145">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006301_5_1_1"/>
    <dbReference type="OMA" id="DPFVAGN"/>
    <dbReference type="OrthoDB" id="361630at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01887">
        <property type="entry name" value="IF2_eIF5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03702">
        <property type="entry name" value="IF2_mtIF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03692">
        <property type="entry name" value="mtIF2_IVc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000008">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10050:FF:000001">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000019">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="entry name" value="Translation initiation factor IF- 2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00100_B">
        <property type="entry name" value="IF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053905">
        <property type="entry name" value="EF-G-like_DII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044145">
        <property type="entry name" value="IF2_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006847">
        <property type="entry name" value="IF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000178">
        <property type="entry name" value="TF_IF2_bacterial-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381:SF20">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22042">
        <property type="entry name" value="EF-G_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04760">
        <property type="entry name" value="IF2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="Initiation factor IF2/eIF5b, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01176">
        <property type="entry name" value="IF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 14" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tr-type G" evidence="13">
        <location>
            <begin position="237"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="510"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="343"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="7"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="510"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMF08777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="784" mass="86373" checksum="06E7395F9AAEB615" modified="2013-05-01" version="1">MQQDESAASHRFEPIGGRRLERAGDVNYSHSDRDASAHHARRSDRLDVDQEGGENAPALDTRQLRRKAARKSRWADAEEDEVVVEKSRGAGRKAQRAGRQEYDEDEDEEAEARERFRARKAARQAEKEAREEERRRSARREREVKKAEDATPIAIPEFVSVQQLSQLLGVRYEQFIESLQDLGYDDVFPGMTLNSETSGMIAMEYNFDPTIDTGVREEEERDLKPRPELEDQQFLPTRPPVVTIMGHVDHGKTTILDYLRKSSVAAGEAGGITQHIGAFSVPMASSGTTITFLDTPGHAAFLAMRQRGANVTDIVILVVAADDSVKPQTLEAIKHAKAAGVPMIVAINKIDKEEADIERVKQDLARHGVEIEDYGGETQIVPVSGKTGKGMDELEETVVALSEILDRRAEIDGPVEGWVLEATTKERGRVATVLVRRGTLKPGAVIVAGKTWARVRTLRNEGGRELSKVGPGMPIEVDGWRDQPMAGDEVLEAPTEQKATSVTEFRQELDERQRAAADMEAINESRRRASERQRKEREAAEAMKQAQRTANAEGGTADVSIKPDNLDAPQQEQTTGQMDVPFIIKADVSGSAEAVSTYILSVSNPLIAPSILLSQVGPIHESDIELADAAGAHIIAFNLPPDPQMQGQAEARGIKILENNIIYRVLDDVKAVLEEKLPPIVSQRVLGEAEVSAAFEISLGGRKKMMIAGCKVRNGTVGKGSRVRIMRGSEKIYDGSITSLKNVKKDVTEMRKGTECGIGFDGWEGFEVGDQVQTYEVISEKRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M3CY35</accession>
    <name>M3CY35_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_151853</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757088.1">
        <property type="nucleotide sequence ID" value="XM_016907081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CY35"/>
    <dbReference type="STRING" id="692275.M3CY35"/>
    <dbReference type="GeneID" id="27904218"/>
    <dbReference type="eggNOG" id="ENOG502SNDN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019101_0_0_1"/>
    <dbReference type="OMA" id="GIFIMIC"/>
    <dbReference type="OrthoDB" id="2988756at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF152">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="28"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF08967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="399" mass="44344" checksum="95F337AB8D86BCC3" modified="2013-05-01" version="1">MGMPGPSNDALFTEVWVEYAISMLLILLRFFARWRVFGFEKFDLGDVFAGLAMVCYSLTAAGIYMLITYGNNIGLNEQTAMQVPADKIADLTLGSKLAFIEWFWYITLLWSLKGVLLMVYVKLGTGIDRQELLVRLVCAFAFLSWLGSILCHALICMPISKSWQIQPYAGDKCTMRPANYIVIAVLNGLSDLAIIAVPMPLLFKVKVHPSRKVALILLFSMGIFCIIATILRAYYSLTSLDTLAIALGWASRETFVGTFVACVPGIKPLFSTTKWIRSSADGSRSRLSMDKPSRGSGSRYLSFSKKPSHNVIEGDGTITVSRSVDVYRSQRPSMDMGNAYGVEMGKWKSQHTSSGSYASDERVIMDDEHELKSKDSHKSAQCSVREFFLGEATKSKDHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M3CY80</accession>
    <name>M3CY80_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_73426</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF09022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757143.1">
        <property type="nucleotide sequence ID" value="XM_016910026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CY80"/>
    <dbReference type="STRING" id="692275.M3CY80"/>
    <dbReference type="GeneID" id="27907163"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008362_0_0_1"/>
    <dbReference type="OMA" id="WTVFRCT"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="2"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="79"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="132"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF09022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="973" mass="108294" checksum="D98D539A90594864" modified="2013-05-01" version="1">MVFCTYCGQSFTRDEHLERHILTHTNVKPFKCFTCHMSFARRDLLQRHYTVHGKDQTGQHEIPAAAGMIPKSAGRTPIACSNCAKTKTKCDKKFPCSRCAGRNLRCTLRPTRRVSKNAARVGVTVEGAVAVPQPNSENHAQQQESQQQTAAPVPTDSPQQGPPSTQPVSPKAVLNSISEEQQHHAEPSVDGPPTQYAEQPTSGGPLPPSSFSPPLHTPGFMQHTPLSGYAEFANNMGKDSSDDDSSPRFMLDWSQMQMPMGYDGLVPPHMIMNAEMGFDTTILSSNDAMLSILPDVDGGMGPLLTPLETPKIQGAFADLELSATATLPSQHRPSMVSMVSSQSVPSNPSTPSSDTNGEIFEIIQAQDAWSVFQCTPVLPSSACPKTAKRNLERLEDTLRNHEGWASWSPSWDETDLAGGDHLTVMQLHESTRDKLLAITQSFLHKALEIHREGDGRRSSGTGYHSPNSYYGSNFVLLPPARVLEYFLRSYSNSFERYYPLTSRGVLDANELLHCHNDRAASLLVLMMIAQGAMNISSTEARLLTGGLTEACRISLFDLIERNIIMSGDPIVLHSALLFIVQAAWSGDKWQMDIAMGQRGMYLAMLRHSGMLDKPVPSTSVNQHSSRDQLWQEWIRNESKSRLIYSWIMVDQDMALFHDTAPLFTVSEFAAPMPDADRLWQAKSAVEWSSVFEQVHEFSGGYSSVGSGARPSSLRDLFRHFLDDEMVPLGIEMTPLHLRLLLHPLQSLVCQYSQLLGCFSETRSSRTQGQTRAVSASSTRHRLEEVQSLLGRWFDLAERYLRANPLCPMMQTNLIIFHLISLNAVTNFPEIEKLARRENFDGTYQQLVWTHKRCIHDVEEAIYHCGQVLRIVRSMSGGTRPPWWAGAIYRAGLVLWTDSLTHKEQSSPHNNNGMFPSVPGPSFAIDAFTADHPLIVRYLTKREGVPCVTKRDGSQISSFDRGELGQTVEILVYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2022-12-14" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>M3CYJ6</accession>
    <name>M3CYJ6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_121030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF09152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757273.1">
        <property type="nucleotide sequence ID" value="XM_016901656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CYJ6"/>
    <dbReference type="GeneID" id="27898793"/>
    <dbReference type="HOGENOM" id="CLU_2401060_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="93" mass="9936" checksum="4D331D00266DC151" modified="2013-05-01" version="1">MSHSSQATPTALAASPAFGFSDLGCEDNKPLSETNPPPTKGIVFNNNGIFTSSDKQAQALHCSYSDNSEYLAAGEQIAQSNLHHNTRCLCLHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M3CYR7</accession>
    <name>M3CYR7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EKC/KEOPS complex subunit BUD32</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Atypical Serine/threonine protein kinase BUD32</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">EKC/KEOPS complex subunit bud32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_92962</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756927.1">
        <property type="nucleotide sequence ID" value="XM_016910601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CYR7"/>
    <dbReference type="STRING" id="692275.M3CYR7"/>
    <dbReference type="GeneID" id="27907738"/>
    <dbReference type="eggNOG" id="KOG0192">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_31_3_1"/>
    <dbReference type="OMA" id="YKICSHD"/>
    <dbReference type="OrthoDB" id="1668230at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="4"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF08806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="287" mass="32569" checksum="A1287C4DF0C2D372" modified="2013-05-01" version="1">MRESAIQWPLGLGARDLVGAGITAVVARLDAVVKFCEPSRSHFLEREKLVYQRLGHDHSGIVRYFGAFENAIVLQFASHTSIRQYFARQKKTQVPLTLKLRWVEQLFDAVRFIHSRNVLHGDISCNNVFLDDNLDVKLGDFAGSAIDDHPPLICYETSHELPGEEDISAMTELFALGSTVYEIMTGVKPYKELPEHEISAAFSEARYPDLGTVPVFRSTIMRCWSQSYATVDEALEEVRSEVATNKDLRVSLTHHLFGRRSVFIHCLLTAVSLIPLVGWVRRWRLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M3CZY9</accession>
    <name>M3CZY9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_165856</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758325.1">
        <property type="nucleotide sequence ID" value="XM_016908192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CZY9"/>
    <dbReference type="GeneID" id="27905329"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_25_3_1"/>
    <dbReference type="OMA" id="FPLWEVY"/>
    <dbReference type="OrthoDB" id="4161376at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010573">
        <property type="entry name" value="MFS_Str1/Tri12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF109">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06609">
        <property type="entry name" value="TRI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="400"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="528"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="41"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF10204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="563" mass="60462" checksum="FC90342AAFBC8A36" modified="2013-05-01" version="1">MASSWEEEVVLVVLLKVIPAWQKRFDQHKEADDIPWTAKRMIAVLSLCTIYVGSQIILYFTSSALTSISQSLGTTIGNWMLTANTLAVAAICPFVGYITDLMGRRSIALLGTLLLLIACTLQATAHSLAQAIAAQAIGGMGAGMAELVALAGVAEITPVRWRGVTLALVTFSIVPFMPQLLYTILIVRSSTWRYCFLLCALWNLIGMIGLIFCYHPPPRPNAEGLTKMEIVKRIDWLGAFLSIVGITLFLVGLQAGGYQYPWTSGKALGPLIVGGLITFVAFPLWEVYGRHPFPMVPPKIFKGQRVVALAYVVVFVAGLEFYSILGFFPLVLQYVYNTDAITTGVRGLCYPCAILGGACLLSFSMSYTRGHVRLMFFSMAAVMTAFTGALALSTPDNPGYTITMATFAAFGNGALVVPALTLAFYAAPDEFVGTVGALSLSVRFIGGSIGTSIFFNIFFTKFSEFLPRNVAGAAMSAGVSDPTILKALVVAYASQVPGAASVVQGVTATTVAATQYASQMAYAEALKYVWYATIPFGVVSCICCAFLPNIRQFMTSKVAVDIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>M3D004</accession>
    <name>M3D004_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_110599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758340.1">
        <property type="nucleotide sequence ID" value="XM_016900853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D004"/>
    <dbReference type="GeneID" id="27897990"/>
    <dbReference type="HOGENOM" id="CLU_1571623_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF10219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="170" mass="18789" checksum="22C94156BB5F5254" modified="2013-05-01" version="1">MSFMPRRMVVRGEHDQDIRPCDPLLIFRRKWREDSRSIGTCLHIDTVPPIMEVQECGGYDVTNRTVRPAYLLGGGRGGGRGARLFLEISPSQTATDHIQSFAVPASKVGQHPTQLQAAMGEQASRAESRVDSTSLRPAERAENKKDTARATCITSFARDEKHANLDSGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M3D019</accession>
    <name>M3D019_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Serine peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_90655</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF09833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757954.1">
        <property type="nucleotide sequence ID" value="XM_016910533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D019"/>
    <dbReference type="GeneID" id="27907670"/>
    <dbReference type="eggNOG" id="KOG2182">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023630_1_0_1"/>
    <dbReference type="OMA" id="MRYFRNA"/>
    <dbReference type="OrthoDB" id="1735038at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000165">
        <property type="entry name" value="Serine peptidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF23">
        <property type="entry name" value="SERINE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032975" evidence="6">
        <location>
            <begin position="18"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF09833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="567" mass="62915" checksum="A91D03E0F9F95197" modified="2013-05-01" version="1" fragment="single">MKSFFAFCAAAAALVCAESQLAAHSDHNPWDWNGGYPHGGWGTSRHMPGGQKPMQQDYYSNSTFKQLIDHNNPDLGTFDQFYYYDTTYWKGPGSPVILFTPGEVNATRYYSYLGTNRTTGLLAQQIGAATIVLEHRYWGTSTPVTELTTDDMQYLTLENSIKDLTYFAQKVELPFAKHAKSNAKDVPWVTMGGSYSGALSAWTASVDPGTLWAYHASSAPVQAVSDYWGYFLPVQEGMPKNCSKDVSKVIDYMDGVFMNGTAAEQHALKAKFKMADVEHNDDFMAALENGPWLWQGNQFYTGTGFFDWCDYVENAYNVTSLNFTVPGAEGVGLQKALNGYAKWWTEVMLPDYCSAYDYPEFQGPLNTACFDTYNASSPLYTDTSLSNPIDRQWVWMTCNEPFGYWQDGAPTSRPSIVSRLVTADYWIRQCGLYFPPGTNGSTYGLARGRTEAHVNAYTGGWNITSTQRLIYVNGEFDPWRESGVSAELRPGGPLKGSGDVPVEVVTGGFHTSDLITMNGEVNEACREVQERVLKQLGEWVGEWPGEEKGPGGYDGGGGKMMMRKGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M3D2H0</accession>
    <name>M3D2H0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_149092</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760526.1">
        <property type="nucleotide sequence ID" value="XM_016905334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D2H0"/>
    <dbReference type="GeneID" id="27902471"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_1_6_1"/>
    <dbReference type="OMA" id="PYFFIEQ"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF234">
        <property type="entry name" value="MFS-TYPE TRANSPORTER DBAD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="266"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="323"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="353"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="431"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="461"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="487"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="526"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="554"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="196"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="77"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF12405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="597" mass="65098" checksum="3DD6F9EE75114E5D" modified="2013-05-01" version="1">MAHARDDSLHRPLRESPLHSRAPSTASDWNGTFDRPTTSDAKGSYRELEYVDSSRAPVFPGTNRTYDGAIPARYDYASLQPSPAQESFGHVDSPTRQAFLPQESNRPASPGFHPGFPRPETPSSPYDPSPKTWPGSPLKVPMNSSHADSNSSLSLKSIYNEYFRTMPREDRISPRKEGARPPGPPGGPPPDGGTTAWLQVLGGYFLFFNTWGLINAFGVFQTYYKGTLLPTTSNSAISWIGTLTSFFLCASPITWGPLFDVGNPRLLVLFGSFSVVFGLMMTSLCEEYWQLILAQGVCCGIGGGCLFITATSILPSYFSSKRALVMGISASGSSLGGVVYPIIFIYVQPTHLGFGWAVRIIGFIALLTLAIPCIVIKPRVRPPGRRKIFNAQILKDVPFQIMNLATFFGFVGQYIPYFFIEQYAAKYHLGLEFWMLIFLNIGSIPGRILPAYIGDKYFHPLKVLATTTASATILAFCWIGIRHSTAGLVVWCFLYGFFSGAFVSLQGAAVASMTPPQEMGSIGTRFGINMFAGALGILIGSPVGGAIFPKSWPGAQSFCAASLTCATLCVVGTWVAWQAQVKRERGKQGGEKMMEMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M3D2K0</accession>
    <name>M3D2K0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL15</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">L29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_149116</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760561.1">
        <property type="nucleotide sequence ID" value="XM_016905352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D2K0"/>
    <dbReference type="STRING" id="692275.M3D2K0"/>
    <dbReference type="GeneID" id="27902489"/>
    <dbReference type="eggNOG" id="KOG1742">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109163_1_0_1"/>
    <dbReference type="OMA" id="WGRVGQH"/>
    <dbReference type="OrthoDB" id="61900at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.100.10.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L27a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_uL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_uL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_uL15_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="8">
        <location>
            <begin position="72"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00080124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF12440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="149" mass="16586" checksum="033DE4B1D7DB8E9B" modified="2013-05-01" version="1">MPTRLSNTRKHRGHVSAGHGRVGKHRKHPGGRGLAGGQHHHRTNMDKYHPGYFGKVGMRYFHKMQNGFWKPVINLDKLWSLVPQEQREKALAGGKSDTAPVLDLLPLGYSKVLGKGRIPAIPLIVRARYFSKDAERKITEAGGVVQLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M3D389</accession>
    <name>M3D389_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Delta 8-(E)-sphingolipid desaturase</fullName>
            <ecNumber evidence="5">1.14.19.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">SEPMUDRAFT_149068</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">SO2202</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.18" evidence="5"/>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760485.1">
        <property type="nucleotide sequence ID" value="XM_016905318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D389"/>
    <dbReference type="STRING" id="692275.M3D389"/>
    <dbReference type="GeneID" id="27902455"/>
    <dbReference type="eggNOG" id="KOG4232">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016265_3_1_1"/>
    <dbReference type="OMA" id="LYNCNYF"/>
    <dbReference type="OrthoDB" id="260091at2759"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03506">
        <property type="entry name" value="Delta6-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353:SF30">
        <property type="entry name" value="DELTA 8-(E)-SPHINGOLIPID DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="FATTY ACID DESATURASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015921">
        <property type="entry name" value="FA_sphinglp_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="411"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="18">
        <location>
            <begin position="31"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="102"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EMF12364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="571" mass="65620" checksum="E4A4556A06363367" modified="2013-05-01" version="1">MATPRHCSRYKDVLLSRANIEALIATGRKVVILDGAVLKVDAWLPYHPGGDKAILHMVGRDASNEIKAFHSQETQQLMQKYCIGKIEGQWTDFVPPIQGGEFRTEEQQRATSSSVVEEQDEEDETQDSSASSQTSSPLFEASDHDQSNIRRRRGSCAGASESSATSLDTLAIGEPAIHDKREYPAEERTQQERDHDLATYPSLDQKTQATIIHKYKELDEKLKAAGLYSCNYTAYAIETTRYTLLACLAYYFLQKQWYILSAAFLGMLWHQLVFTVHDAGHMGITHNFHIDSTIGILIADFLGGLSCCWWKRNHNVHHIVTNSTEHDPDIQHMPFFAISHKFFSNLTSTYYDRIMTYDPFAQFVLKYQHYLYYPILSFGRFNLYVLSWQYIFLGQGPRKGPAWWHRYLEMAGQAFFWYWFGYLVVYKSVDTNLHRFLYVLVSHAITMPVHVQITLSHFAMSTSDLGVAESFPQRMLRTTMDVDCPTWLDFFHGGLQFQAVHHLFPRMPRHNLRTAQKFVMEFCEEVGIPYTIYDFAEGNGKVIGRLGDIAKQARIMSECQKAAFRDVIEGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M3D5D8</accession>
    <name>M3D5D8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AMP-activated protein kinase glycogen-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_124959</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761220.1">
        <property type="nucleotide sequence ID" value="XM_016901943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D5D8"/>
    <dbReference type="GeneID" id="27899080"/>
    <dbReference type="eggNOG" id="ENOG502STER">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_687297_0_0_1"/>
    <dbReference type="OMA" id="PTEMECT"/>
    <dbReference type="OrthoDB" id="5350410at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050827">
        <property type="entry name" value="CRP1_MDG1_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE , BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343:SF84">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="95"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="162"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="275"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF13099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="401" mass="44016" checksum="9B5BDE63281C9049" modified="2013-05-01" version="1">MTTPITIKFGSPGLQPPVYIATSLSDPQWEPIEMEGTRNASGEYTFTKKFDAQEGEYQYKLRLGPGDWWICDDTKPQVDDGMGNKNNLVTVKAGHSQEHRADSVHGDQGAPLMPHESHDQAADASPFLNAERSSARPVTPDAEHQAPFFRHESLVPEASREDAEEEEDEEEEEEEPPSPLLRHETAIPTHEDVSPLFHHKSTAIDDQKHETLSKKSPLLRGRKHSGDSIPEEADPNDPGLEKFPTDHRGIIDSIARTKKALAIDETSDHQPSPSPLAKSAAASPKLNSVVEVEDEEHCDRDNNVPEVQLSEADHRPAAPITPPETPTKEKHVDPMVNRVQKKAKSAKETAASAAEQAAQKVGTTNYSTALTGSMFAFAVALTAIGLWYFSEGGRNLDIIET</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M3D749</accession>
    <name>M3D749_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_147852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF13980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762101.1">
        <property type="nucleotide sequence ID" value="XM_016904552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D749"/>
    <dbReference type="STRING" id="692275.M3D749"/>
    <dbReference type="GeneID" id="27901689"/>
    <dbReference type="eggNOG" id="ENOG502SBHE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136313_0_0_1"/>
    <dbReference type="OMA" id="VEVRWTN"/>
    <dbReference type="OrthoDB" id="5555533at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070096">
        <property type="term" value="P:mitochondrial outer membrane translocase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037652">
        <property type="entry name" value="Mim2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28230">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28230:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19117">
        <property type="entry name" value="Mim2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF13980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="117" mass="12825" checksum="C890CE1C4225EF2A" modified="2013-05-01" version="1">MSDPSSSYARIPSAASDIDDDDGFDSLPSSSAGSTTSLSPSEEEAYSDAEREWRESLQQLELMMTLVLIPYLGKYFGRKCAYYGWAKFMEWKYPVTVEITSPGLFKGVGAIEAAASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M3D766</accession>
    <name>M3D766_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Membrane anchor Opy2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_147863</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762121.1">
        <property type="nucleotide sequence ID" value="XM_016904561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D766"/>
    <dbReference type="STRING" id="692275.M3D766"/>
    <dbReference type="GeneID" id="27901698"/>
    <dbReference type="eggNOG" id="ENOG502RY3X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030352_0_0_1"/>
    <dbReference type="OMA" id="HMVCIAN"/>
    <dbReference type="OrthoDB" id="2402916at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018571">
        <property type="entry name" value="Membrane_anchor_Opy2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09463">
        <property type="entry name" value="Opy2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Membrane anchor Opy2 N-terminal" evidence="3">
        <location>
            <begin position="35"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="326"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="368"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF14000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="537" mass="56315" checksum="727B37E38B414D93" modified="2013-05-01" version="1">MAEVGIRDNVVARAPGWTAAGTEVERTMRSIFKRCVECGPVTPTCPACPSGDICSLVPQTCDECAHMVCIANPSPAPPAAKTNVGAIAGGVVGGVAFMAFLLFLFWRYWAKKRRAQHDQWEIEDEDDLATQKGQSQFNAMKSDAASTKTSRSVAASFLSRASNIIHIAYIPGVTNRFGSGHNSMTAPVPPIPAAYANRTPQTTTPRSPLSHEGDALFFRPSDLRDSTWSDGSSLRSGKRDTQYTTHSITPSLARSSLMSDIYRDDATTEPMPATQVFRALPRMVSVKSFSASATSTPSMETPPTLGPSPGGSGGSGVKAVMLGEQPSITSSPSSHHTGGTFAKATPVTIGGGGGKGKGRIPVVTQQTSNASSLSPPGSSTSRPPASTRSSPLVETANESDDAKEEDEEEDERSRARKSLIRESTAAAASPAPLIQPLESPFFDATELRTPASSTIIPRPNPYAAMSASVGSGPRTKRFNSNIGGDNRGPGGLSAVIEEAAKRASQDPDQDGSSEGGDGTVKRDPSPFADNHAYTASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M3D836</accession>
    <name>M3D836_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_39926</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762150.1">
        <property type="nucleotide sequence ID" value="XM_016908764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D836"/>
    <dbReference type="STRING" id="692275.M3D836"/>
    <dbReference type="GeneID" id="27905901"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022195_1_0_1"/>
    <dbReference type="OMA" id="YTTMGSR"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF6">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE AN1598-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF14029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="388" mass="43654" checksum="E24352480986B2E7" modified="2013-05-01" version="1">MGSRSTLHPRVVRGQLNRNLWTVMSEVEEEISDAFNDSWPACDDWTEVDVNDRIVQIVARVSSRMFGGTTLSRNKEWVQASINFATDGFIGAQALKAYPEILKPIAARFIPAIQQIKKHYEAAEKAAIPLLNQREKTGEAAPDLLYWMAQDAKDSSEKDKKFLAGILLKVSFAAIHTSAAAPTQLLYDLCAMPEYIEPLREEIRKNTSEESLMTRKNYEGLTKLDSIMKESQRHNPLLLITFERVITKNYTLSDGFVIPAHTTIGIPTHAISMDPEIISNPEKFDGFRFAQSSTSSTTNNNLPDDKTPSNLYAAARPTSMAFGYGRHACPGRFFAAAEIKAIMVFLLKNFEFKFPEGKGERPVSLIFETQNLPNPEGRVLFRRRRDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M3D8X6</accession>
    <name>M3D8X6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rad1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_148086</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762470.1">
        <property type="nucleotide sequence ID" value="XM_016904692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D8X6"/>
    <dbReference type="STRING" id="692275.M3D8X6"/>
    <dbReference type="GeneID" id="27901829"/>
    <dbReference type="eggNOG" id="KOG3194">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035332_0_0_1"/>
    <dbReference type="OMA" id="WSQAYKF"/>
    <dbReference type="OrthoDB" id="337581at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003021">
        <property type="entry name" value="Rad1_Rec1_Rad17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10870">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10870:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02144">
        <property type="entry name" value="Rad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01245">
        <property type="entry name" value="RAD1REC1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF14349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="337" mass="36566" checksum="9097C1664AEC69EF" modified="2013-05-01" version="1">MATTNPLLFSAVSSSARQILLLLRCISFSKMKCSATVRITPDGLRLSTEEGSVMEAFVHLEKNLFTSYKYTIPEADPSSQDEPLEHPIFEVNLISLLETLNIFSVPDPSAAKRPDDYSAFAAHRLNRHANQNAFNHPLHVAGICTFSYDGEGSPLSIHMSEAGVTTTCDLTTYEAEVAEEIPFRRESLALKAIMRSAVLLDTLSELSNMNPQNLTIQASPDSRTANLSLSASGPLGSSMVDFTTHTDSETPILETFQCPSKTAASYKFSSVKAAQRAMQSASKVSLRLDEDGVLSLQFLVEIGYGEGDGAAFVDFRIVPLVDGEAEGDHGDDSDRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M3D9T7</accession>
    <name>M3D9T7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_148297</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762765.1">
        <property type="nucleotide sequence ID" value="XM_016904832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D9T7"/>
    <dbReference type="STRING" id="692275.M3D9T7"/>
    <dbReference type="GeneID" id="27901969"/>
    <dbReference type="eggNOG" id="ENOG502S3QV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043818_0_0_1"/>
    <dbReference type="OMA" id="FSAWGRY"/>
    <dbReference type="OrthoDB" id="436519at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052243">
        <property type="entry name" value="Mito_inner_membrane_organizer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44157">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44157:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="78"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF14644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="370" mass="41992" checksum="15CF59939750D449" modified="2013-05-01" version="1">MASNQLLALASWYFLPRLVTGYIQTTLYSIFIRAGDPKPTPGSARYTRDRRAIHIAVIVAYLLYTLYEADYQIQSAPDFYRLLNVPHDASEKAIQSRFRRLTIQFHPDKAAPGSDKAMIENLYVQLTLAKDTLVHPAKRFAYDRCGPDVLQWSPQHHKVTKDFVLTGLQHILGYYGVSSGVLVLLSTVGYLRQGMFWRYLVLASLFAIEMQTMTRPHFPILLTKIVNPFMLMTGLRPAYLPFQMITLLRKFAVTVFIAMSQLGPLLQDPKQTALEEGDASGGVPGPLLDRVDELTNATNSELSRLMQMELIPFASEPSAGRQLRETLKNWLVQNNLRNDPEVNMAIQQVLERRRAEGRGHSTDVRVEGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>M3DA64</accession>
    <name>M3DA64_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Cation-transporting ATPase 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SEPMUDRAFT_37042</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>[protein]-with a C-terminal TM segment(out) + ATP + H2O = [protein]-with a C-terminal TM segment(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66168"/>
            <dbReference type="Rhea" id="RHEA-COMP:16963"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:90782"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF14970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763091.1">
        <property type="nucleotide sequence ID" value="XM_016908660.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.M3DA64"/>
    <dbReference type="GeneID" id="27905797"/>
    <dbReference type="eggNOG" id="KOG0209">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001828_4_0_1"/>
    <dbReference type="OMA" id="QKTKYVW"/>
    <dbReference type="OrthoDB" id="48943at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140567">
        <property type="term" value="F:membrane protein dislocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015662">
        <property type="term" value="F:P-type ion transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07543">
        <property type="entry name" value="P-type_ATPase_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000049">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000054">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000071">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057255">
        <property type="entry name" value="2TM_P5A-ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047820">
        <property type="entry name" value="P5A-type_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01657">
        <property type="entry name" value="P-ATPase-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF7">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE HELIX TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23143">
        <property type="entry name" value="2TM_P5A-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="229"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="P5A-ATPase transmembrane helical hairpin" evidence="17">
        <location>
            <begin position="24"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="16">
        <location>
            <begin position="261"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1290"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1290"/>
            <end position="1304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF23143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMF14970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1312" mass="146028" checksum="154F1976D9BDA3D3" modified="2013-05-01" version="1">MSLRPVEIPIERAEIKSATLHNARPLLLHAYILPFVFLWPLFFSYYLPQASYDTYINGQEWTFVYAGTIVTLQSLTWLMTFWNVNIRALFTASSVNRVRDAGLIKVIPKENAGSSEICTIERERTGGIESVSFLFQKRRFLWDDSKASFAPLTYAIDEEPKPTIGSFQASKGLQKSTEIEKLTQYYGKNLFDIPVPTFTELFKEHAVAPFFVFQIFCVGLWMLDEYWYYSLFTLFMLVVFESTVVWQRQRTLTEFRGMSIKPYAVWVYRENKWVEVQSDALLPGDLVSVGRTKEDSGVACDMLLVEGSAIVNEAMLSGESTPVLKDSVQLRPADAHLDPEGLDKNAFLWGGTKVLQVQHGNASTDAPDTIPQVASGVPPAPDKGALAIVIKTGFETNQGALVRTMIFSTERIGAGNVEALLFILFLTVFAVAASWYVWTEGVKQDRKRSKLLLDCVLIVTSVVPPELPMELSLAVNTSLAALSKLAIFCTEPFRIPFAGRVDVACFDKTGTLTGEDLVVEGVAGLFLGRQDAKVKTEADGAQSQLTRITDTGLETTLTLATAHALVKLEEGDVVGEPMEKATLQSLGWTLGKNDTLTAKAGTNARGALAGDLVQIKRRFQFSSALKRQSSVATVVTSDRHTGKKTKSTFVAVKGAPETIRKMLFDVPSKYEETFKYFSRNGGRVLGLAYKYISTGDEITQKKINDLKRDDVESQLHFAGFLVLQCPLKDDAIEAVRMLNESSHRVVMITGDNPLTALHVAKQVEIVDRDALILDAPEHDDSGKNLVWRTVDDKVNIPVDPSKPLDPEILKTKDLCVTGYGLAKFRDTPQWHPLLRHAWVYARVSPKQKEEILLGLKEQGYTTLMAGDGTNDVGALKQAHIGVALLNGNRSDMDKMAKSFREAKMKEIYEKQKAMMNRFNQPDPPVPAHIAHLYPPGPKNPHYDQAMEREGLVKQKLLEEKVAAAEEKAEATADKYTAPVVEKTEQELKREKAQNAASAMAEKLSMSMMESELDDEPPTIKLGDASVAAPFTSKLANVVAIPNIIRQGRCTLVATIQMYKILALNCLISAYSLSVLYLDGIKFGDGQVTISGMLMSVCFLSISRAKPVEKLSKERPQNNIWNWYIIPSVLAQFAVHIVTLVYITGVVHHFEPPKDRSEIDLEGTFQPSLLNSAIYLLQLIQQISTFAINYQGRPFRESIKENKGMYWGIVLVTSVAFSCATEFVPEINEKLQLTPFTTEFKVKLVVTMIADYVGCWTCEKILKTLFSDYKPKDIAVRRADQLEREQKRLAAEKAKADRKVEEARLGKAGLAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M3DAX5</accession>
    <name>M3DAX5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cyclin-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_147160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763351.1">
        <property type="nucleotide sequence ID" value="XM_016904123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DAX5"/>
    <dbReference type="STRING" id="692275.M3DAX5"/>
    <dbReference type="GeneID" id="27901260"/>
    <dbReference type="eggNOG" id="ENOG502QWSP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013431_2_0_1"/>
    <dbReference type="OMA" id="GFKKWVT"/>
    <dbReference type="OrthoDB" id="244495at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF118">
        <property type="entry name" value="CYCLIN, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="615"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="339"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="500"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="629"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF15230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="639" mass="69798" checksum="120F091830ECE9A7" modified="2013-05-01" version="1">MYVNRAATRFTDPFVSSKDCPPSVQDYARLRNSGVVQVPVQDINRALTPPPEMTGIHSTRPSFHAGDHTQQHVDYVRGKPAYRAPVAAPQSLESTSEYSRNAPVKVYSSSRASPSRHAPVGLAVNPAQQRRASQHHNAIATNFQIPRSVNDSGGSLSELAAQITCLFWFESSDLLQQVEESSTLFQNSKPLAVDSKPTTGFRKWVTTILSTTCVAQNVVILALLFIYRLKKLNPTVRGKPGSEYRLLTVALMLGNKFLDDNTYTNKTWAEVSGINVAEVHIMEVEFLSNMKYCLFTSEQDWAQWQSLLGKFASFFDQANKPAPVRTSLAPILPPASSLHLPNALPSPPASNQASPPYQSELVSSAVQYSAHPHPGPTPVPSLPGNIDYRGSQQAGVKRNRDEAGLEPPAKRLAGGYDYTSPTRYSTMPVHSSSAPTVPRLTLPSLAVQGTQAPASASYPQAPVHNQQLPPLGVQARAMSMTCPDANSQAQSIAPSAPIQQYGQPYAQQASRTHSPQRCGSATVSPSNGVPQSASALHPPPPAQISPTYFLQQRASPYRPVHHVSTLLYPPPSGATQARPTNIELNQMQYQPLGKPTHHTGRLPYLGQNLWTDGNHPQEMTPIHRWPNFPQHQQPLTQQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M3DC23</accession>
    <name>M3DC23_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbohydrate esterase family 3 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_131081</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763500.1">
        <property type="nucleotide sequence ID" value="XM_016902394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DC23"/>
    <dbReference type="GeneID" id="27899531"/>
    <dbReference type="eggNOG" id="ENOG502R2FZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014183_2_1_1"/>
    <dbReference type="OrthoDB" id="2119228at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01833">
        <property type="entry name" value="XynB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051532">
        <property type="entry name" value="Ester_Hydrolysis_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383:SF19">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383">
        <property type="entry name" value="THIOESTERASE 1/PROTEASE 1/LYSOPHOSPHOLIPASE L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032960" evidence="1">
        <location>
            <begin position="22"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="304"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF15379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="642" mass="69853" checksum="51C6C287A8932CF3" modified="2013-05-01" version="1">MPPSILWKSFVVANCFAIASALAHVDIFPSSQAHVQSDTGGASTLRLMFVGDSITHGHEADYTWRYRLWQWLRETETPFSFVGPYTGTCAPAPALPPQPPRLLELPVRGADAIDDFPRTDWGYAREVPQDFDAHHFATSGDRADRVKKLIQSRVQEFTPNVLLILLGFNDLSWGGATPDGLIASLKELIDNARAANPTIKVAVGNVVHEAYSSPSLEDRTTKFNELLRSTYTSWKLPESPVFHVDVAGVYTCGPHRNCTSTADGLHPNELGSYQIAHAFSKTLIEDFSIGQQPVPIPETWTERAVEPPTNVKAASTSMGIKATWDRPWGITDFHVRRRTGGQEWIIDYGVKANRTDTILPEAGIEYEYQVRSCLGRRCGDWSSEYASARSGRNTGPPPETVITSPTELGFHVSWSPPHEHEAAKWNITQYDVSFFNTHTKQDVHVGTLNTSVTLEGLPSGEMSVVGVILDISISAWTSPEGGGTIFTRGRPVLPGALLAPHKPGSLQSRVINESAVQLTWAANDEYTAGYLVYVDGDTNGIATLETEQVVRVPQQRTRSTLPEICVSAVNGELASEKSCLTGDAAAVPESPRVGEPEGGTTTTATATTTTFLAPILTLLILASLVVSMLRCVQGGSDGEIYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M3DC39</accession>
    <name>M3DC39_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Thiolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_147455</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21564"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.3.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763746.1">
        <property type="nucleotide sequence ID" value="XM_016904310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DC39"/>
    <dbReference type="STRING" id="692275.M3DC39"/>
    <dbReference type="GeneID" id="27901447"/>
    <dbReference type="eggNOG" id="KOG1389">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031026_1_1_1"/>
    <dbReference type="OMA" id="RWCASSM"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050215">
        <property type="entry name" value="Thiolase-like_sf_Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853:SF10">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="10">
        <location>
            <begin position="31"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="11">
        <location>
            <begin position="289"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="8">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="366"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF15625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="413" mass="44231" checksum="D33A984499361E8E" modified="2013-05-01" version="1">MATERVKSILGQLLPGQSPLDKITQKNPDDIVITLAIRTPLTKGRKGGLKDTPLDGIVFKILEQVVKKSNLDPAQVEDICLGNVSDSKAAYYCRAAMLAAGFPNTTAGSSVNRFCSSGLKAVQDIANQIIHGDIECGVAVGAESMSAGGDALSRPFFEDILKASQEAVDCMMPMGQTSENVGKDFNITREQQDRYAAESYRRAEVAQKAGWFDDEIVPIKAVVDGKEVTLTRDEGPRYGTTFESLNKIRPAFPDYGDRSTGGNSSQVTDGAAAVLLMKRSKALELNQPILAKFVGATVAGLAPRIMGIGPSVAVPKLLSKYNLTVDDIDIFELNEAFASMAVYCKDTLKIPHEKMNVRGGAIALGHPLGCTGARQIVTGLSEARRQQKKILLTTMCIGTGQGMAGLFVNEQNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M3DEP1</accession>
    <name>M3DEP1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydro_1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_147691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764100.1">
        <property type="nucleotide sequence ID" value="XM_016904466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DEP1"/>
    <dbReference type="STRING" id="692275.M3DEP1"/>
    <dbReference type="GeneID" id="27901603"/>
    <dbReference type="eggNOG" id="ENOG502QRDE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023620_2_0_1"/>
    <dbReference type="OMA" id="DVFPGPR"/>
    <dbReference type="OrthoDB" id="5311681at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01299">
        <property type="entry name" value="Met_dep_hydrolase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051781">
        <property type="entry name" value="Metallo-dep_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057744">
        <property type="entry name" value="OTAase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135:SF3">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="1">
        <location>
            <begin position="88"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF15979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="460" mass="50257" checksum="CBBB3280F0004CA3" modified="2013-05-01" version="1">MTPPPPSLPAPPLKPWTTSIPRKRYRLIDAKLIDPKDGSLHEHVTIDIKDGIIHRMTKLDSGPTGPHDEVFKWTNNEQMTMINLEGRFLLPGLIDCHVHLATPPGEDGLKDTMNQHPDTALLRQPYLAREILKRGFTTIRDCGGAGLAVKEALAEGLYPGPRLFIAGHGISQTGGHGDMRSSKDDEYACCGGNTRGLGRIADGVEQCLHAAREELRQGADFLKVMLSGGVVSPTDKLTNLQYTPEEIRAFTKVASDSGTWVTAHAYTPAAIRNAVENGVLGIEHGNLIDEPTAELMAKHNVFLTPTLITYQTMASKEFGTFLPPSIATKNLQVLEAGLRSIQIADKAGVTMCYGTDLLGPLEVMQASEFSLRKQAGLSNLKIIQSATVNAARMLRQDDKLGRIKEGYIADLIILNANPLEDVEVLARPQKHLLAVIKDGRVLHSRWSKLFPDTEQAAVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M3DES2</accession>
    <name>M3DES2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_154689</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCA family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF16014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764135.1">
        <property type="nucleotide sequence ID" value="XM_016907578.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.M3DES2"/>
    <dbReference type="GeneID" id="27904715"/>
    <dbReference type="eggNOG" id="KOG0059">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001640_2_0_1"/>
    <dbReference type="OMA" id="WKNWIVL"/>
    <dbReference type="OrthoDB" id="8061355at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03263">
        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001345">
        <property type="entry name" value="Related to ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF36">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="219"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="364"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="407"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="816"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="975"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1017"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1051"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1081"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1117"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1160"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="455"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1225"/>
            <end position="1452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF16014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1637" mass="179820" checksum="B159121C47046D15" modified="2013-05-01" version="1">MMFIRQTWALVEKNLRIVLYRHWLGTLIRAFLAPIIFMFIIAYAKNFFVPPSDFGIGNPVPVRTLSSALAASAGGRNLVVAVDNGFTNGDIASVIATIREPIEAGGKTFQLAANEQELLSLCPSSIRAVSPCFGAVVFDSSPSEGSGGIWNYTIRADGSFGERVYVNNDDNDAEIYTLPLQRAIDSAIASLGGATLPETQEFVFTTKTSEERSRNIIRLYMGTLIDILGLAYFIGMVGICYQLTGQMASERELGMSQLIEAMMPNRQRWMPQAARLLSFHISFDILYLPSWIIMGVIVAGLNYTDSSTGMCVGYFIVSGLALSSWSIAFAALFRKAQLSGITVVIASIVLAIIIQVAPAPSTGAAYIATLLCPPINFTLWIIYMAYWQQENIAADLSQAAPNAPWRVPGYIFFIFSILQIFLYPVVGALLERTLYGTATKSRQLRYEESESRETVKITSLSKHYPPGWWSRNIGARLSKNPKETVYAVNDLSLSVIKGQIMVLLGANGSGKSTTLDTLAGLQKPTSGTIEMDAAGGIGLCPQKNVLWSELTVYEHVRLFNRLKATGKLDSKVENQALVSACDLDQKINVRTSALSGGQKRKCQLAMMLTGGSRVCMLDEVSSGLDPLSRRKIWDIILAERGRRSMILTTHFLDEADLLSDDIAVLSRGNLVAHGSAVELKHHLGGGYRVRIYHEDSKELPGDLIATTRKQVYHDQTVYHLADSAASFRFITELERLGVRDYQVNGPSIEDVFLKLAEEVKDELEKGRESSPAPSEDGTLVSEEKRLQLMPGRQLSFFAQTWVLFRKRVTILIRNKWPYLAALLIPIIAAGLVTLFLKNFRALSCAPQDQVQEARTLSLNTGLAYGANIPVGPGEEQLTEIRDTYPILDVNTSATVLVNTFADFQTYVNANYSFVTPGGFFNGDTPTFAWRGDYGIQFAIAAQNLLDNSLLGTQIQTSYQPFDEPWAPSAGSTLQLILYFGLAMSIFPSFFALYVNMERLRNVRALHYSNGVRAGPLWLAYTLFDFIIVLLVSAIAIIIFTAASSVFYAPGYLFVVFFLYGLSATLTAYVVSLYTTSQLATFAFAAGGQCSFFLLYFVAFMCIITYVPAADVDSSIRIATFTMGLVFPSANLLRALLLSLNLFSVTCTGSQLASYPGDFKVYGSCILYLILQSAVLMLVLVWYDSGWTPAFLARTKHRNADLEQIDDTDSEVFEEAKRVDGATDQLRVKHVTKAFGPFVAVQNVSFGIPHGETFALLGPNGAGKSTTINLIRGDMRPSEKDSDILIEDISIIEKRAAARTHLGVCPQFDAMDQMTAIEHLRFYARARGVQDVEHNVDQIIHAVGLAPFKNRMAGKLSGGNKRKLSLGIALTGNPSVLILDEPSSGMDAASKRVMWRTLSAVSAGRSLLLTTHSMEEADALADRAAVMAKRMLAVGTADELRKKHGDAYHVHCVHKDAPYSSEHDMAEIKSFIHRTFPGAITEERSFHGQIRFSVPGDRTAAAAAAAHGGEDEISLDQDEKLHIIDDKKEILATVSPAVASAHHHSSSSDSSPSSSNSISALFSHLEAHKAALGLEYYSVSQATLDQVFLSIVVKHNVLEENYAKFHDAEQLQQQQQRGGAEMVWRKMKRVMATVYHNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1QD78</accession>
    <name>N1QD78_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_52354</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat PROPPIN family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757341.1">
        <property type="nucleotide sequence ID" value="XM_016909221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QD78"/>
    <dbReference type="STRING" id="692275.N1QD78"/>
    <dbReference type="GeneID" id="27906358"/>
    <dbReference type="eggNOG" id="KOG2110">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025895_5_0_1"/>
    <dbReference type="OMA" id="NIAILEM"/>
    <dbReference type="OrthoDB" id="1667587at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048720">
        <property type="entry name" value="PROPPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11227">
        <property type="entry name" value="WD-REPEAT PROTEIN INTERACTING WITH PHOSPHOINOSIDES WIPI -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21032">
        <property type="entry name" value="PROPPIN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="265"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="267"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="287"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF09220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="436" mass="47799" checksum="3E53C111CAA36590" modified="2013-06-26" version="1">MSGLNYVTFNQDHSLLAVATTRGLRVYTTDPFELTNHSYEEDISLVEQLFSTSLVAMTLTPRHLRIVNTKRTQRHSTICELTFHGMVVAVKMNRKRLVVLLEEIAFIYDISNMKMLLQHPTPLNPAGICAISPSSENNYLAIPHYQRTGHNTNAPPAHVPNSAAARESVSGDVLLYDLGREEEVTVIQAHQSPLSYIALNNDGTLMATASEKGTVIRVFSIPSGKKLYQFRRGSMPARIFCISFNATSTLLCVSSATETVHIFKLAPPGSNPNNGNTPRPISPPSSPRHSSFSSSRQRSESPIQSEIESSEQNLDGDPSALASAPQPRQAGFMSLVRRTSQNVGTTIVSRAAGYLPSSVTEMWEPQRDFAWVRVPRGANGQPVRCVVAMANSVPHVMVATSEGDFYVYMVDLEKGGEGTLVKRFEYVEPSDTVSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2023-02-22" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDD8</accession>
    <name>N1QDD8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_135776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757477.1">
        <property type="nucleotide sequence ID" value="XM_016902731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QDD8"/>
    <dbReference type="GeneID" id="27899868"/>
    <dbReference type="HOGENOM" id="CLU_1046508_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="266" mass="29927" checksum="055B7C578583681A" modified="2013-06-26" version="1">MLAFNFGSSRGELGFGSWIKSHVETISGSNLLIGNRRATLMTTTRRRPCIDVRGCAPMLTLCMPYSEVEEFEANFHQEALKGLGLCAHNKYPFVALPKTRIAKIAAIGLEPVDAWTSPFGMFESTYDRRLDSHNEDHEFILDAAWTVCGLHPLNVSTSIFVRTCLPSPLVPESHEATKCIRMALASRALRNRREAGRPSLGLAQVLPTQPEKRGCFYLLRSWHFPPHLVLSSSVTWRTTYQNGTEMHEVPRQRRMTQGDAKFGTLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDE3</accession>
    <name>N1QDE3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA(Ile)-lysidine synthetase</fullName>
            <ecNumber evidence="1">6.3.4.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_72043</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cytidine(34) in tRNA(Ile2) + L-lysine + ATP = lysidine(34) in tRNA(Ile2) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43744"/>
            <dbReference type="Rhea" id="RHEA-COMP:10625"/>
            <dbReference type="Rhea" id="RHEA-COMP:10670"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:83665"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.19"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="6.3.4.19" evidence="1"/>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757506.1">
        <property type="nucleotide sequence ID" value="XM_016909965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QDE3"/>
    <dbReference type="STRING" id="692275.N1QDE3"/>
    <dbReference type="GeneID" id="27907102"/>
    <dbReference type="eggNOG" id="ENOG502QQNE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015599_1_0_1"/>
    <dbReference type="OMA" id="HRYWIRV"/>
    <dbReference type="OrthoDB" id="434144at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032267">
        <property type="term" value="F:tRNA(Ile)-lysidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01992">
        <property type="entry name" value="TilS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01161">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012094">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012795">
        <property type="entry name" value="tRNA_Ile_lys_synt_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02432">
        <property type="entry name" value="lysidine_TilS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43033">
        <property type="entry name" value="TRNA(ILE)-LYSIDINE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43033:SF1">
        <property type="entry name" value="TRNA(ILE)-LYSIDINE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal" evidence="8">
        <location>
            <begin position="39"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="511"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="519"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF09385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="581" mass="65106" checksum="5C6D1884ABC48292" modified="2013-06-26" version="1">MYYSARLLGAFTEPISSLRSQVYKGLQYQLNASPKGRLGLAVSGGVDSMALASICSDFKKENQLHYSFSGFVVDHGLRSESREEALQVANELRRLDIEPEILKLDWTPYGNPKDLPNFETIARRLRYQAIGKACFQQRISTVLVGHHADDLGETVMSRIVARYLGEGLQGIKWTALIPECEGIYGVDASGKPHSINSSNTHTRKKERRKSAMSDAMLIESGGVYLNRPLLLFTKAQLIEICQKDNVQWFEDDTNSDKSLTIRNTIRYLQQTGSLPAALQRPRLVDMAKTIRDKYGMYEQRAKAIFDSMSIQLDMRTSTATFSLPENVDFGATANGETYRVRAVLARKLLMLVSPLHTMSLQDLDSAVESMFSEASDIATKTQIQGVIIQKQSFPGADKGTNITISRTPPDRLSIMTPIKLSALRVDDEPPHEGRRRYWTEWLLWDNRYWIRVGCLSSCDVEAKRLHFFVNFLTPETIHHLRSKSFSPGGAVRARVNAVLRMAGESKKWQPVITTKLDDGDGDDDDDDDGKGSTGKGNSAEEAIALPALGWTKRTEFVKRMGIVCQARYKAVEFGDGKHHQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDK5</accession>
    <name>N1QDK5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="11">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SEPMUDRAFT_72315</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="11"/>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757651.1">
        <property type="nucleotide sequence ID" value="XM_016909984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QDK5"/>
    <dbReference type="STRING" id="692275.N1QDK5"/>
    <dbReference type="GeneID" id="27907121"/>
    <dbReference type="eggNOG" id="KOG0348">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_26_2_1"/>
    <dbReference type="OMA" id="IHEQICE"/>
    <dbReference type="OrthoDB" id="422663at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000464">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17949">
        <property type="entry name" value="DEADc_DDX31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="15">
        <location>
            <begin position="149"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="182"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="465"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="40"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="474"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="10">
        <location>
            <begin position="149"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="482"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMF09530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="776" mass="84797" checksum="21662DE787B11890" modified="2013-06-26" version="1">MADDGFTLNFELPSDAFTVPTTKLKGGSWKDRLTARKSAEYGRKKAQERGVSGVSLPDQSGIKLSRAKGPAASDADAPERVDRYAAEGRPAKRARVGHDVLPKTNDGQVITSLFSFNKAATVPREAKPETSEETTVEASNAPLENDETAKFTSLGLSPTLAAHLLKKLNITAPTAIQRKAVSQLVSHDTDAFIQAQTGSGKTLAYLLPIVERISLISRRMKDEGAKFDRHSGLFAIVLAPTRELARQIADVLESLLSCYHWVVGGTVIGGENKKSEKSRLRKGLNILVATPGRMADHLENTEALDLSNVRWLVLDEGDRLMELGFEQDIQKIISVLNLRSRKRVEKPVPGLPERRTTVLCSATIKSNVEQLRAISLKDPVSIAVDSDPTAEGDGEAIENNFSAPAQLKQGYAIVPPKQRLVTLVATLKQQFKRKGSVLKCIVFMSCADSVDFHFELLTRGDKTAAVEDEVASVAKQHKPGKHSNSSVDRNKIAQGNTIAETRTEGTAASLSSRESGDIKIFRLHGSLQQTTRTSTLKAFSTCEDPAVLVCTDVAARGLDLPNVDLVIEYDPPFSKDDHLHRIGRTARAGRDGRAMIFLQPGCEEGYIEILKEGKPKNLTRHESEELLRKGFSPTSGVVLGREWEQIATDYQLEIERWALENPKHLEQARRGFQSHVRAYATHVSAERSIFNMQELHLGHLAKAFALRDKPGAIKVPGLRPGAGTNKKGKSHAIQNGKRTVSGAMDDVEAVADADAAKRKMQQMSRKMGGASEFNLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDM9</accession>
    <name>N1QDM9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sphingosine-1-phosphate phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_151559</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the type 2 lipid phosphate phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757712.1">
        <property type="nucleotide sequence ID" value="XM_016906890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QDM9"/>
    <dbReference type="STRING" id="692275.N1QDM9"/>
    <dbReference type="GeneID" id="27904027"/>
    <dbReference type="eggNOG" id="KOG2822">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019266_0_0_1"/>
    <dbReference type="OMA" id="ADDCPCY"/>
    <dbReference type="OrthoDB" id="301434at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042392">
        <property type="term" value="F:sphingosine-1-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03388">
        <property type="entry name" value="PAP2_SPPase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969:SF28">
        <property type="entry name" value="DIHYDROSPHINGOSINE 1-PHOSPHATE PHOSPHATASE LCB3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="10">
        <location>
            <begin position="102"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="413"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="463"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="421"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="485"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF09591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="548" mass="60961" checksum="1E53EBEA581892D1" modified="2013-06-26" version="1">MADKTINLRFQAHLRTASPDPDAGLRGLSHYERRLPRWRYHLRQALIPIVRKETAYLAKVQQAARSPLLDSYFAMTANLGTHTFFMTALPVCFWCGYPVLGVALVQMLAAGVYLSGYAKDMVCLPRPLSPPLQRITMSGSAALEYGFPSTHTTNAVSVAVYCLHYLWTTQDQFSTWAYVLSVLGCLSYATSISIGRMYCGMHGFSDVIFGAILGALIAVCRVALGPAFDAWLLADGWTRPGLVAFLMALAVRFHPEPADNCPCFDDSVAFVGVVMGVSIGIWNYAQMQSALDGSAPALDNMYLFENWDIFKVGARLVLGIVMIFAWRAVTKPLLLRTLPPTFRFVSHYGVHIPRRYFLQSRDYKTVPYLRKDDKVLPPASDIPSMLNAIRRRKRTISVGPQSEADARELIANREQARRPKLQSSTSSLQVPRSSAHEQALVMTPEEPHDESTSYLAVTRSDAHFSTTTTKDTRNTTRASLLTPPASDNGTCSDSGNEEEKSDRRMFSNIEKPRVRYDVEVITKLVVYAGIAWLAVQGNPLLFEKLGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDQ4</accession>
    <name>N1QDQ4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_120488</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016901608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QDQ4"/>
    <dbReference type="GeneID" id="27898745"/>
    <dbReference type="HOGENOM" id="CLU_436262_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="57"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="112"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="269"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="439"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF09650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="627" mass="69363" checksum="DDF23DDBEFAE6BF1" modified="2013-06-26" version="1">MAEEENKPTLTALGADYVDAQVASAENIQGSAASGGAATPSDFSDFQFPSTLVKYGVSAFDDDDDEDDDDEVEDGQDHDGDLAIDESKFNKFPAEDYSIAIDQSVFEDFDSYNPELVDEYDSSGDDLNNRPNPNPARPRSTSSAGRALEPIGTYEPTRSRSLDSSLPGPSDGAQALYQKAQQRVTNPTPQIRSRASSRLDGSGPVPAVRINTRTGDPGPNRMGKDVQPKSCGVKRATSLFGRSIKPSYVPPVSSPFNPNPSVLPLSSFEPGVTSTVDPTMEPVSPLQYGPSTSKGPRKGTHQRSSAVSHPAGDVIFPAIPYTLPGSFKMPATPEELEELTGMDRETGLAAGAELAIARQKKEDAARFLKVQRSFLKFETEAENIKRADAGQPLVPGSDRIPEIREERAQFTRALLHEYHERYTTMRQQWHERRLVEKRLEQTRAELFQMTSKRDSLQEALTSVEEELDDTFELQHSKQAEQNTKFQRLQNEYSKLKEEALALQGQYYSASEAVQSLEITLAEQSAEVDALKLRCAELERSNELLRRSRHLSPAPEEGSDAATAAAAAAAAKKKGEISARQQQQQFYNSPFWLAESSRRQKILLELEIRQAEMQRAREEAWEVLLSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1QE12</accession>
    <name>N1QE12_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GABA permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_134841</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758616.1">
        <property type="nucleotide sequence ID" value="XM_016902664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QE12"/>
    <dbReference type="STRING" id="692275.N1QE12"/>
    <dbReference type="GeneID" id="27899801"/>
    <dbReference type="eggNOG" id="KOG1289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004495_2_2_1"/>
    <dbReference type="OMA" id="YSMAEMC"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF8">
        <property type="entry name" value="PERMEASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="483"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF10495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="548" mass="59036" checksum="6F6C16671DCF48EB" modified="2013-06-26" version="1">MSGPLEKHEQHHHHVFGQDAQEEVALEALGYQQELKRSFGLISMIGFSFSIVTSWSALSGVLIIGAESGGPPVMIWSWIGICAASLAVAYSMAEMCSAYPVAGGQYSWVAMLAPKKVARGLSYICGWFMLIGLLAMGATNNFIVANFILGVSNLNHPSYVIQRWQTVLVAYGVGLASLAFNILGPKLLEKVSRGLLIWNVCAFFIIVITILSMNDHKQSAAFVFRDFVNETGFSRSYTAIIGLLQAAFGMCCYDAPAHMVEEIHNPRKEAPRAIILSVYLGFITGFVFLIAACFCMAGIEETALSSTGVPIIEIFYNSTASRAGASCLTVLLIVIGMGGSNALTVTGGRAVFAFARDRGLPFSPIWAKVEKKSQIPVMAICLTVAVQMALNSIYFGTVTGFNTVVSIATLGFYVSYAMPLLTRLASLLFAGSRGPAATIQGGLYTLGRWSVPMNSIGLLYLLFTSITFNFPTISPVDSENMNYTSAAVGAIMLISLVTWITTGKRQFAGPEIVHPAVIIEGREPHHDALDEDLIHEGRSIAVSTKGQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>N1QE29</accession>
    <name>N1QE29_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_69750</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758661.1">
        <property type="nucleotide sequence ID" value="XM_016909874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QE29"/>
    <dbReference type="STRING" id="692275.N1QE29"/>
    <dbReference type="GeneID" id="27907011"/>
    <dbReference type="eggNOG" id="KOG1807">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001066_2_0_1"/>
    <dbReference type="OMA" id="EWIMVEA"/>
    <dbReference type="OrthoDB" id="409395at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06008">
        <property type="entry name" value="NF-X1-zinc-finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057373">
        <property type="entry name" value="ZNFX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF341">
        <property type="entry name" value="NFX1-TYPE ZINC FINGER-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25396">
        <property type="entry name" value="ZNFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZNFX1" evidence="5">
        <location>
            <begin position="133"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="3">
        <location>
            <begin position="316"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="4">
        <location>
            <begin position="707"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1013"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1101"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1024"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1101"/>
            <end position="1117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF10540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1165" mass="131191" checksum="81B246975DD8D5EC" modified="2013-06-26" version="1">MNEDLQERFTRSKKPVRDDGGPRGSAQVMILPPKINAQVSEYYVEPVVTDGGWLAKPEVPTAEEVLDLYDDDISSPDVVELPTNRVKGAWESKEEYLSAQYLLNREDSVRGLREAVTNIRLDPDKTEDFFDGKFGIYEKVHICGITASPRGLAHRITFSTRRAGKVILWEQSKRLIAGSLVVLTPAKDKFQSTAIVATVAARPLEYLKLNPPEIDIFFARSEDFEVDPSIEWLMVEDKGGLYEANRHTLLALQRMMREPFPLSHHILDAKMAVGPPKYVRDRPVLDLSKVLHNTANQSFENVDVLNGWPLDAQSVLDESQLAALQHILTKELAIIQGPPGTGKTHVSVQAVRVMLDNWKQGDPPIIVACQTNHAIDQFLRHIAAFEPDFVRLGGRSKDRDIVKKRTLYQVRISTSENPPAGGLYGKARKVIRGLEKQVRLLLAPLLPTHKPLDHRLLEDFKLLTQAQADSLDAGAARWVQSKKSNPVEAQSPFMVWLGDKLIHVDPKQLNNEHGFDREEADLEQERLREEEAENAAQDDEEFEKLSGSYFDVADNFTCRKVPGVDHKVKELLQEQDMWKIPESSRGAVYRHLQSAVKQHILPALRDLAKKFDVEARKRRIGQFERDEPILKRQKIIGMTTTGLSKYRGLLAALQPRVVLIEEAAETLEAPVTVACMPSLEHLILVGDHKQLRPHTHVSAHENEPWFLNVSLFERMVNNKVEWSTLRKQRRMIPEIRRLLHPIYGNLIKDHPSVTDPECRPDVPGMGGVNSFWFTHSWTEGRDDLMSCHNEDEAKMIAGFVEYLSYNGVQPQDITILTFYNGQRKKLLQELRSRIVLRDCRFTVVTVDSYQGEENKVVILSLARSNDHGQMGFLSVENRVCVALSRAQCGFYIFGNALLLHKIESGKTWTTVMNIMAGKEVKEMDDMELVHRQRFNAFFTVRCKNHGNEVQIHHPDEWTLHGGCKQVCQAQLPCGHDCTLLCHPMDHEDVNCTKCRGRPVGSVDSKLTAAIQGAPATLSKPASRETCSSENSSWRSYASSAQEQHHQAIASYVPHSQRPGHAEDLVKISSSGSLFSIDADVDRLSLGPDSASTITPSYITQAEHRPMYRSDGGADRSDSPAGVPMGGGDGKRFKWAETYRPAGLQAPKEPKKDLSEEVNLIDFDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFE0</accession>
    <name>N1QFE0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sugar phosphate phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_164265</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>beta-D-fructose 1-phosphate + H2O = D-fructose + phosphate</text>
            <dbReference type="Rhea" id="RHEA:35603"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:138881"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>beta-D-fructose 6-phosphate = dihydroxyacetone + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:28002"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
    </comment>
    <comment type="domain">
        <text evidence="7">Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.-" evidence="7"/>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760033.1">
        <property type="nucleotide sequence ID" value="XM_016908103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QFE0"/>
    <dbReference type="STRING" id="692275.N1QFE0"/>
    <dbReference type="GeneID" id="27905240"/>
    <dbReference type="eggNOG" id="KOG3870">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030117_2_1_1"/>
    <dbReference type="OMA" id="IFARQKM"/>
    <dbReference type="OrthoDB" id="541375at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097023">
        <property type="term" value="F:fructose 6-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103026">
        <property type="term" value="F:fructose-1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.60:FF:000002">
        <property type="entry name" value="Protein-glutamate O-methyltransferase C1393.13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10880">
        <property type="entry name" value="Uncharacterised protein PF01937, DUF89, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036075">
        <property type="entry name" value="ARMT-1-like_metal-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039763">
        <property type="entry name" value="ARMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002791">
        <property type="entry name" value="ARMT1-like_metal-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260">
        <property type="entry name" value="DAMAGE-CONTROL PHOSPHATASE ARMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260:SF6">
        <property type="entry name" value="DAMAGE-CONTROL PHOSPHATASE ARMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01937">
        <property type="entry name" value="ARMT1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111321">
        <property type="entry name" value="AF1104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Damage-control phosphatase ARMT1-like metal-binding" evidence="8">
        <location>
            <begin position="23"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF11912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="490" mass="55267" checksum="282B8CDB643BDEBC" modified="2013-06-26" version="1">MEYDTTVPQSGTADPNSFAYISARERWPVILTGAIDDIHKAVSEQTSAEKIEEGKKITNEIAAIKYELQHNRPLTPLPDDGSSADIAAYNQELEQRGNPKWHNVAWLYAECYLYRRIATIFAQSTHWKRYDVFSQQKMSTFRDSRPAVLELAARYNELVRHLESNKESALLGSSASSSEEERFQAEKILFVEMSEICLWGNATDLSLLTNLSYEDIQKLQGSHARKANEDKIIVNDFDQAFETLYQAQKAGAKERRVDIVLDNAGFELFVDLILTGYLLQSGLATQVILHPKNIPWFVSDVTPQDFADLLSVLMNAPQFYETPSEADLARNKTPPPLSAQETSHLQSLCQNWSTLYAQGQIILRPNSFWTEAGSYWRLPQTAPALYQDLQESELVIFKGDLNYRKLTADAMWDPTTPFSEAIGPLGRLGSGMRVLALRTCKADVVVGLPEGKDEELRKLQDGGENGDGKKRKWAWSGKWAVVSFWDGKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFN3</accession>
    <name>N1QFN3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF323 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_151383</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757429.1">
        <property type="nucleotide sequence ID" value="XM_016906778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QFN3"/>
    <dbReference type="STRING" id="692275.N1QFN3"/>
    <dbReference type="GeneID" id="27903915"/>
    <dbReference type="eggNOG" id="ENOG502QS9T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006921_0_1_1"/>
    <dbReference type="OMA" id="FKHWHPT"/>
    <dbReference type="OrthoDB" id="659at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052706">
        <property type="term" value="F:L-histidine N(alpha)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052699">
        <property type="term" value="P:ergothioneine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903257">
        <property type="term" value="P:selenoneine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="entry name" value="paralog of FGE (formylglycine-generating enzyme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051128">
        <property type="entry name" value="EgtD_Methyltrsf_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019257">
        <property type="entry name" value="MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017805">
        <property type="entry name" value="SAM_MeTrfase_EasF-type_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03439">
        <property type="entry name" value="methyl_EasF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397:SF1">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10017">
        <property type="entry name" value="Methyltransf_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine-specific methyltransferase SAM-dependent" evidence="5">
        <location>
            <begin position="29"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase-modifying factor enzyme-like" evidence="4">
        <location>
            <begin position="557"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="605"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF09308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="855" mass="96797" checksum="F7B99F71ECE1AB6D" modified="2013-06-26" version="1">MGSIGAPEYTSQADIIDIRSDAAGIELKQLIYSGLRAQDGSKEKTLPTLLLYDTKGLRLFEQITYLDEYYLTGEEIQVLEQHAERIAERVPNNALVVELGSGNLRKVKILLDALDRAGKTIEYYALDLMRPELERTLAAVPKHAFKHVQCYGLWGTYDDGLEWLKRPENAARPKTILSLGSSIGNFTRDEAVGFIAQFAETLKPTDSFLLGLDACQDAERVYRAYNDRDEVTHGFTMNGLHHANHILGHEEFVIADWEAVGEYDQVGERHRAYVVPKKDVVVQGVAVKKGEKVRIEESYKYNHKQSMQLWSNASVVESAAWSNQSGSYALHMLARPATMYPTKPEAYAPHPVPSIPEWEQLWAVWDKVTRQMIPNEELLEKPIKLRNACIFYLGHIPTFFDIKINEVTALGLTEPSYFTKIFERGIDPDVDNPDQCHDHSEIPDEWPALETILKYQNDVRNRVRDLYKSNRVYEDNWAGRAMWLGFEHELMHLETFLYMALQSDKTLPPDGTIRPDFEQLAAKAKRDAVPNEWFTIPEQSVTIGMNDPDTPDGPVRQFGWDVEKPAYTTKVHSFKSAARPITNEDYVRYMIAKDIEKIPASWTTQNKRDSGINGHANGRSNGEFHDSNGHTNGDVRLEHFIGDKFVRTFYGAVPMKHALDWPCSASYDELNGCAMYMGGRIPTMEEARSIHEYAAHLKKKEADKAQGKTIPAVNSHLVNEGVEESPGSKPATNGFGREADPYQGKELHVDLGDANVGFKHWHPMPVTQNGNKLAGLGEMGGLWEWTSSVLEKRDGFEPMKLYPAYSADFYDGKHNVVLGGSWATHPRFAGRKSVVNWYQRNYPFVWAGARLVKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1QG90</accession>
    <name>N1QG90_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">ER membrane protein complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_110094</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758963.1">
        <property type="nucleotide sequence ID" value="XM_016900826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QG90"/>
    <dbReference type="STRING" id="692275.N1QG90"/>
    <dbReference type="GeneID" id="27897963"/>
    <dbReference type="eggNOG" id="KOG3318">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098404_2_0_1"/>
    <dbReference type="OMA" id="QQTFKVI"/>
    <dbReference type="OrthoDB" id="369569at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009445">
        <property type="entry name" value="TMEM85/Emc4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19315">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06417">
        <property type="entry name" value="EMC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017207">
        <property type="entry name" value="UCP017207_TM-p85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="32"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF10842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="195" mass="21558" checksum="EBA85A7C3C6E21C4" modified="2013-06-26" version="1">MALTLPQPQPQWLVDLNTTALVPAKNTTALADPPGYSAPAPASSKANKKAVSTRKVPTTEEMDSLKSPLTRRFSRLKKAWELALAPAKQLPMNAIGMYMTGNGLQIFSIMMVFMLFKGPIQAVLNIQNTFSRLESPGNKEQMIMVKLAFIGCNLLALALGIWKVNAMGLLPTTRSDWLAWESAREPIERAIYVQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGK5</accession>
    <name>N1QGK5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_133632</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759725.1">
        <property type="nucleotide sequence ID" value="XM_016902572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGK5"/>
    <dbReference type="STRING" id="692275.N1QGK5"/>
    <dbReference type="GeneID" id="27899709"/>
    <dbReference type="eggNOG" id="ENOG502STNU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1815476_0_0_1"/>
    <dbReference type="OMA" id="KRRCQEW"/>
    <dbReference type="OrthoDB" id="5271495at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046670">
        <property type="entry name" value="DUF6540"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20174">
        <property type="entry name" value="DUF6540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF11604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="147" mass="16296" checksum="28E1B7C9C2B4303A" modified="2013-06-26" version="1">MAYVLSIAVDGPGTDPNHRSHWAFAIHKRGVGRGDVMHVALLDLERLIYQFDSRKDVEFRSPGSEGSFEVGYLTREHMRQAVEIISREPAPRDGVQKCQDWILSAVISLEAEEIVPPGTSDLISKLVGQPAVVVAQAVGERWTMTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGX8</accession>
    <name>N1QGX8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribose-phosphate diphosphokinase</fullName>
            <ecNumber evidence="4">2.7.6.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SEPMUDRAFT_145682</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="4"/>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764556.1">
        <property type="nucleotide sequence ID" value="XM_016903198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGX8"/>
    <dbReference type="STRING" id="692275.N1QGX8"/>
    <dbReference type="GeneID" id="27900335"/>
    <dbReference type="eggNOG" id="KOG1448">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033546_4_0_1"/>
    <dbReference type="OMA" id="LLPEHKC"/>
    <dbReference type="OrthoDB" id="413572at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000005">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000014">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002320">
        <property type="entry name" value="PRK01259.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF32">
        <property type="entry name" value="RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="13">
        <location>
            <begin position="7"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMF16435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="321" mass="34914" checksum="1E4E0E13BC52F9DD" modified="2013-06-26" version="1">MSTTNSIKLLTGNSHGGLAKLVADRLGIDLAKIMVLQYSNNESSISIGESVRDEDVFILQSTEPGNINDHIMELLILINACRTASARRITAVLPNFPYARQDKKDKSRAPITAKLMANMLQTAGCQHVITMDLHASQIQGFFNVPVDNLYAEPSTLRWIRENLKVDDCVIVSPDAGGAKRATSIADSLDLQFALIHKERARPNEVSRMTLVGDVRGKIAIIVDDMADTCGTLVKAADVVMEHGAKEAIAIVTHGILSGNAIEKLNGGQLKKLVVTNTVPHEEKKTLCDRIHTIDIAPTLAEAIRRTHNGESVSFLFKHAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1QH38</accession>
    <name>N1QH38_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_127187</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 81 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="3"/>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758594.1">
        <property type="nucleotide sequence ID" value="XM_016902131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QH38"/>
    <dbReference type="STRING" id="692275.N1QH38"/>
    <dbReference type="GeneID" id="27899268"/>
    <dbReference type="eggNOG" id="KOG2254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005482_2_1_1"/>
    <dbReference type="OMA" id="FALKYKW"/>
    <dbReference type="OrthoDB" id="4473401at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052861">
        <property type="term" value="F:endo-1,3(4)-beta-glucanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1170">
        <property type="entry name" value="glycoside hydrolase family 81 endo-[beta] glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.30">
        <property type="entry name" value="Golgi alpha-mannosidase II, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005200">
        <property type="entry name" value="Endo-beta-glucanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040720">
        <property type="entry name" value="GH81_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040451">
        <property type="entry name" value="GH81_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31983">
        <property type="entry name" value="ENDO-1,3(4)-BETA-GLUCANASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31983:SF0">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-D-GLUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17652">
        <property type="entry name" value="Glyco_hydro81C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03639">
        <property type="entry name" value="Glyco_hydro_81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52008">
        <property type="entry name" value="GH81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 81 N-terminal" evidence="9">
        <location>
            <begin position="1"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 81 C-terminal" evidence="10">
        <location>
            <begin position="305"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF10473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="679" mass="74463" checksum="229442C710A428D6" modified="2013-06-26" version="1">MVVSHTEPGQWATSPGQAGKDAGQWAFFGAPVGIQYLVLSASELVENPNDGKTPGLTTQSLEWGSVKANLYPPNWMTPVMTVPLVQGSAFITAEYHWGKPLIQSSVGFKNITFAGALPNNLTYKYQASLRNGHTWLIYITPLDASYEVNRFDLDGAGSSINGPSWFNGFIQVAKIPQPGSADPLKRRDTVFTETDPEKIYDASAGTYAIGLNITGSVNGQSGSYTLSWTKNGTLDQDLLMFALPHHTASMSYPDQNGLTNLQLRTTTKGLATAVKGDSWTMTEKELPINMGFAPWTPDQGDVTQFSDSALKAIQRAGADDIRQDILGQTNVSSAYYDGKALAKFAATCYTLHDIVGNDTLALSGLQPLKQAFANHIDNLQTWPFVYDSSWGGVVSNASYVTGNPLEDFGNPYYNDHHFHYGYFVYAAAVIGYLDPEWLGNSTNKDWVNMLVRDYANSDLDDPYFPFSRSFDWYHGHSWAAGLFDSGDGKNQESSSEDTMSSYAIKMWGQVIGDAAMQARGNLMLAVQKRSLASYYLYTTDNTVEPSSFIGNKAAGILFENKIDHTTYFGAEPEYIQGIHMLPLLPLSPYVRTSTFVCQEWDAYFANITSDGSNTKKISTVQGGWRGILMANFAMCNTSTAREAYAFFSGDEMDQSFLDGGASLSWYLTFVAALVDGVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>N1QHE5</accession>
    <name>N1QHE5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP-dependent (S)-NAD(P)H-hydrate dehydratase</fullName>
            <ecNumber evidence="9">4.2.1.93</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP-dependent NAD(P)HX dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_145825</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(6S)-NADHX + ATP = ADP + phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19017"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.93"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>(6S)-NADPHX + ATP = ADP + phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32231"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.93"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the NnrD/CARKD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.93" evidence="9"/>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764731.1">
        <property type="nucleotide sequence ID" value="XM_016903289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QHE5"/>
    <dbReference type="STRING" id="692275.N1QHE5"/>
    <dbReference type="GeneID" id="27900426"/>
    <dbReference type="eggNOG" id="KOG3974">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030651_0_0_1"/>
    <dbReference type="OMA" id="WRAAYHN"/>
    <dbReference type="OrthoDB" id="8110916at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047453">
        <property type="term" value="F:ATP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110051">
        <property type="term" value="P:metabolite repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046496">
        <property type="term" value="P:nicotinamide nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01171">
        <property type="entry name" value="YXKO-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000043">
        <property type="entry name" value="ATP-dependent (S)-NAD(P)H-hydrate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01965">
        <property type="entry name" value="NADHX_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017953">
        <property type="entry name" value="Carbohydrate_kinase_pred_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000631">
        <property type="entry name" value="CARKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00196">
        <property type="entry name" value="yjeF_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12592:SF0">
        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12592">
        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01049">
        <property type="entry name" value="YJEF_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01050">
        <property type="entry name" value="YJEF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51383">
        <property type="entry name" value="YJEF_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="YjeF C-terminal" evidence="10">
        <location>
            <begin position="10"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="173"/>
            <end position="179"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="212"/>
            <end position="216"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF16610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="327" mass="35331" checksum="5DD3D97E6A79DC9D" modified="2013-06-26" version="1">MTSDMSRKEVLGNVFKMVPPMLEKFHKGQLGRVAVIGGSEDYTGAPYFSAMASAKLGADMSHVICEPGAGAVIKTYSPNLMVHPYMRQKKNLAHNETIDNISDSVIAMLDRLHVIVIGPGLGRDEAMQETCARVITEAKKRNVSFVLDADGLYLAQTRPELVEGYKECILTPNVVEFGRLAKAKKIDTTKEDPKTLCSKLATAFGGVTIIQKGPVDYISNGTQTLVSDGEGGLKRSGGQGDTLTGSLATLLAYRKAYLDKIWDHEGDMKADELLAYAAYGGSAITRECSRLAFKEKGRSLQAADLTEHVHQAFLNVIGEKGSDGAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1QHM2</accession>
    <name>N1QHM2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_145917</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764862.1">
        <property type="nucleotide sequence ID" value="XM_016903339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QHM2"/>
    <dbReference type="STRING" id="692275.N1QHM2"/>
    <dbReference type="GeneID" id="27900476"/>
    <dbReference type="eggNOG" id="KOG0598">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_43_1"/>
    <dbReference type="OMA" id="CEVDWWS"/>
    <dbReference type="OrthoDB" id="354826at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004703">
        <property type="term" value="F:G protein-coupled receptor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05578">
        <property type="entry name" value="STKc_Yank1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000354">
        <property type="entry name" value="AGC/YANK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000469">
        <property type="entry name" value="Serine/threonine-protein kinase 32B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355:SF30">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 32B ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="20"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="9">
        <location>
            <begin position="277"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="364"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="460"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="532"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="369"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="410"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="559"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF16741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="584" mass="65128" checksum="40A1457343BF466E" modified="2013-06-26" version="1">MGNSNGKPVVLTDEVNLNHFRLLRVVGKGAFGKVRIVERKDTGLTFALKYIRKDEVVRSESVRNIIRERRMLEHLNHPFLCNLRYSFQDVEYLYIVVDLMNGGDLRFHISRKTFTEEAVRFWISQLGCALRYIHKQGIVHRDVKPDNVLLDSEGHVHLADFNVASDITPGKPLTSKSGTLAYLAPEVYAGKGYYSEVDWWSLGVLFYECIYNKRPFEANHHDALAQAIVKADPPFPVTSPPVSMPCLHAISSLLEKNKHLRIGAAGFETFTDNPFFRDIDFEALENKEIEPIFCPSSEKTNFDATYDLEELLLEEAPLEARARKQKPRAELREDATQQEIRADELHRMIETMFEPFNYTALPQDRSPVASVSDSPTATKSSTRLPRGTEGPGDPNYARHTLEKARAVPTPRSQTPGSASRTRSSTHSPEGSPPLPVGTLEIGVAVGHPPENYVPSVADAVQHAAPDSRESPRSRAIRYENIAPATPPVTSTKAYQQHRPRGSTRSTSQGGGVQVVLNEHGSWTDMANQSQAMVAPGDDLRRAERPSGMLGFLNRKKGRDRSPKAKEKERGVLGKEGARVIISHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1QHR9</accession>
    <name>N1QHR9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Vacuolar aspartyl aminopeptidase Lap4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_45699</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase M18 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760120.1">
        <property type="nucleotide sequence ID" value="XM_016908975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QHR9"/>
    <dbReference type="STRING" id="692275.N1QHR9"/>
    <dbReference type="GeneID" id="27906112"/>
    <dbReference type="eggNOG" id="KOG2596">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019532_3_0_1"/>
    <dbReference type="OMA" id="DWPIAKI"/>
    <dbReference type="OrthoDB" id="9880441at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05658">
        <property type="entry name" value="M18_DAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.250.10:FF:000001">
        <property type="entry name" value="Aspartyl aminopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.250.10">
        <property type="entry name" value="Aminopeptidase i, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001948">
        <property type="entry name" value="Peptidase_M18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023358">
        <property type="entry name" value="Peptidase_M18_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570:SF4">
        <property type="entry name" value="VACUOLAR AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02127">
        <property type="entry name" value="Peptidase_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00932">
        <property type="entry name" value="AMINO1PTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101821">
        <property type="entry name" value="Aminopeptidase/glucanase lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9 10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF11999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="501" mass="53424" checksum="4572D5EE46A0B681" modified="2013-06-26" version="1">MDRALQDAKIHAPRFRQATRENAAAYTKPFCDFLTDNPTVFHAVDALKKQLKDAGFTEISERDTWKIECSGKYFVERNGSSMIAFVVGANYQPGNGAAILAGHVDALTAKLKPVSQVPNKAGYLQLGVAPYAGGLGRTWWDRDLGIGGRVHIKEGGKIVTKLVKLDWPIAKIPSLAEHFGAPAAEPFINPNKETRMVPIIGLDTADERATAPLAPADPFARPSLLCSGSPVNSFVQTQPPALVKAIGNALGLNSAETHNIVNWELELFDVQPATVIGLNKELISAGRIDDKLCSWAALQALIESQASDTEHSSLIKVVGLFDDEEIGSLLRQGAKGNFLPITLERAVGALCGHTPGSDVMGRTYANSFMVSSDVSHAVNPNFTEVYLANHAPHLNVGIAIAADSNGHMTTDSVSTTILKRCADMVGAQLQVFQIRNDSRSGGTVGPMLSSALGIRAIDAGLPQLSMHSIRATTGALDPGLGVLMFAGFLNGFEAVDKELQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1QI49</accession>
    <name>N1QI49_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_151590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757760.1">
        <property type="nucleotide sequence ID" value="XM_016906911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QI49"/>
    <dbReference type="STRING" id="692275.N1QI49"/>
    <dbReference type="GeneID" id="27904048"/>
    <dbReference type="eggNOG" id="ENOG502QPYF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018583_0_0_1"/>
    <dbReference type="OMA" id="FFKHMPT"/>
    <dbReference type="OrthoDB" id="5397682at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33604">
        <property type="entry name" value="OSJNBA0004B13.7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33604:SF3">
        <property type="entry name" value="OSJNBA0004B13.7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF09639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="750" mass="84354" checksum="BDA9CBD336D5B72D" modified="2013-06-26" version="1">MRRTAKADEELGKRDDDLHFRPRRSHSHSTSMTASFPFKWRRRRVLAVLALLFLLYVLHLYVPGELATQTDAFRPKPPRTFQGYDAATAKEPKGAPPRDPEAEEQVEEEMQHYYNGVTRFYKLGSTLQKASHTMGAYQVNRNVLFAAASLKSVANLVPLACEMAKNDKSFAHFAVFGRSSLSIEEIQELNGIDKSCTVYWHDARGDYAEYSSDARVESAVRGAMKHIQEYIHPQAMIVDDSSKEEAYFTKAMRAKARDMDKALIEIPRGKYEEFLWITKLDSGSLAQWFKPTIDIVIQAPRGSSGRLIRLLQSLYNADYSGLKVPRLNIELPPDVEPALQRYLSEFSWPPRKDSPLQPNLLTVHHRIPSERMSSEQASLRFVESFYPTQANDHHVLLLSPQVDVSAMYYQYLQYNMLNYRYSAHSLLESNKLLGISLDVPLTTLNGANKFVPPKVTDMILGRVMNENEASPDDPYPFLYQAPSAKATLVLGNKWAEFHDFLTNRLQASHSGVSKKSSKLVSETEPAWLEYLLELMSARDLFVIHPATPFVTIHNELAQIPEEYLKPVNIAKSSAQDAAHSDEEPFILSTEAPVLIEHIEADPDRNRGSLHKMLPLNGVLPDISQLPYVGFDGKITPSSDLDELRDDYVKYFRKAIAGCTGDAATRERQVVPLKTEDLFCFPGQVLKYADEISDFNEAKNIALVLAGMADGAADDDEAIPAKIGGAKTSETQKPDMLKIIIPDKKVKDPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1QIN4</accession>
    <name>N1QIN4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Very long-chain fatty acid transport protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Very-long-chain acyl-CoA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">SEPMUDRAFT_142432</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Acyl-CoA synthetase required for both the import of long chain fatty acids (LCFAs) (C14-C18) and the activation very long chain fatty acids (VLCFAs) (C20-C26) by esterification of the fatty acids into metabolically active CoA-thioesters for subsequent degradation or incorporation into phospholipids. The transport and fatty acyl-CoA synthetase activities are genetically separable and are thus independent activities. Esterifies VLCFAs in the peroxisome matrix. The VLCFAs are actively transported into peroxisomes by a PXA1-PXA2 heterodimeric transporter in the peroxisomal membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:54536"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58950"/>
            <dbReference type="ChEBI" id="CHEBI:138261"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lipid droplet</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760400.1">
        <property type="nucleotide sequence ID" value="XM_016903000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QIN4"/>
    <dbReference type="STRING" id="692275.N1QIN4"/>
    <dbReference type="GeneID" id="27900137"/>
    <dbReference type="eggNOG" id="KOG1179">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_46_3_1"/>
    <dbReference type="OMA" id="RDTRGHC"/>
    <dbReference type="OrthoDB" id="196650at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044539">
        <property type="term" value="P:long-chain fatty acid import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000019">
        <property type="entry name" value="Long-chain fatty acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107:SF6">
        <property type="entry name" value="ACYL-COA SYNTHETASE FAMILY PROTEIN (CEFD1), PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107">
        <property type="entry name" value="LONG-CHAIN FATTY ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="13" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="21">
        <location>
            <begin position="34"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00060276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00068795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00078285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EMF12279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="606" mass="67516" checksum="1EB94F5FC66C7EF7" modified="2013-06-26" version="1">MANTNSQEISVPCSNQKGQNASTHRLVSPWYILAETCARQPNDRAIWTRERSWSFQELHDQTARYAQWMLEQGVQPGDLVAMYLHNSAEFLMVMFATLSIGAGPALINYNLEGKALMHCLAVCESKILIVDADSGCQARITASQQDIEAAGMTIITLDHTLKSQIASRQAIVPPDTLRNGMKGTQPYCLIYTSGTTGLPKGCPFLINRVWLMGSHLSPPLNTVPGKDCWYSPMPLYHGTGIITSSNALLAGVGIAIAPRFSVKNFWPDIHDSKSTLFIYVGETARYLLAAPPHPLETKHNIRTAYGNGLRPDVWSKLQSRFHIPEIAEFFNSSEGMLALVVYSRNSYYSNCVGHHGLLFRRLYNNTYVPVKIDTDTGDIYRSPTTGFATRTSYDEGGEILVSIPSKDAFGGYWRNPSATDKRFATDVFRKGDLYYRSGDALRRSDEGHWYFLDRLGDTFRWKSENVSTAEVAEVLGHISGITEANVYGVAIPGYEGRAGCAALHLSDLSVIENESWRRDVLAQCRKSLPRYAVPVFLRIQKASSHIHNHKQNKVGLRAEGVDPELRGKHEKTGGEDVILWAGPGMDSFREFGRKEWEDLKGGRAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>N1QIP9</accession>
    <name>N1QIP9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Glucose-6-phosphate 1-dehydrogenase</fullName>
            <ecNumber evidence="3 11">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SEPMUDRAFT_149605</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="3 11"/>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759811.1">
        <property type="nucleotide sequence ID" value="XM_016905655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QIP9"/>
    <dbReference type="STRING" id="692275.N1QIP9"/>
    <dbReference type="GeneID" id="27902792"/>
    <dbReference type="eggNOG" id="KOG0563">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013524_2_3_1"/>
    <dbReference type="OMA" id="ERAGYYE"/>
    <dbReference type="OrthoDB" id="60984at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009051">
        <property type="term" value="P:pentose-phosphate shunt, oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000015">
        <property type="entry name" value="Glucose-6-phosphate 1-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000111">
        <property type="entry name" value="Glucose-6-phosphate 1-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00966">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019796">
        <property type="entry name" value="G6P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00871">
        <property type="entry name" value="zwf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429:SF0">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000110">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00069">
        <property type="entry name" value="G6P_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 11" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="6 11" id="KW-0521">NADP</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase NAD-binding" evidence="12">
        <location>
            <begin position="26"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase C-terminal" evidence="13">
        <location>
            <begin position="205"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMF11690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="511" mass="58966" checksum="DD7A18C29EEA0876" modified="2013-06-26" version="1">MASTVIHPDEEHNAGTMELKENTTVIVLGASGDLAKKKTFPALFGLFRNGFLPRDVHIVGYARTKMDHNEYLKRVKSHIKTPTKEMEQQLEEFAKYTTYVSGQYDKDESFQELEKHLAELEKGQKETNRVFYMALPPSVFIPVSEHLKRNNYPKSGIARIIIEKPFGKDLESSRELDKALRPNWKEEEIFRIDHYLGKEMVKNILILRFGNEFFGATWNRNHIDNIQITFKEPFGTEGRGGYFDEFGIIRDVMQNHLLQILTLLAMERPISFSAEDIRNEKVRVLRGMPSIEPKNVIIGQYEKSLDGSKPGYKEDDTVPKESRCPTFASMVAYIKNERWDGVPFILKAGKALNEQKTEVRIQFKDVTSGIFKDIPRNELVIRVQPNESIYIKMNSKLPGLSMQTVVTELDLTYRRRFSDLKIPEAYESLILDSLKGDHSNFVRDDELDASWRIFTPLLHYLDDNKEIIPMGYPYGSRGPAVLDDFTSSYGYKFADAAGYQWPQHQIEPNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJG8</accession>
    <name>N1QJG8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_149780</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760076.1">
        <property type="nucleotide sequence ID" value="XM_016905764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJG8"/>
    <dbReference type="STRING" id="692275.N1QJG8"/>
    <dbReference type="GeneID" id="27902901"/>
    <dbReference type="eggNOG" id="KOG2022">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005271_0_0_1"/>
    <dbReference type="OMA" id="CLASIGK"/>
    <dbReference type="OrthoDB" id="2016913at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051345">
        <property type="entry name" value="Importin_beta-like_NTR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057942">
        <property type="entry name" value="TPR_TNPO3_IPO13_3rd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363:SF33">
        <property type="entry name" value="IMPORTIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363">
        <property type="entry name" value="TRANSPORTIN 3 AND IMPORTIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24140">
        <property type="entry name" value="TPR_TNPO3_IPO13_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF11955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1005" mass="110974" checksum="2A56A8501A52D652" modified="2013-06-26" version="1">MDANSLVSAPTSLDEVEQLVKRLYQPGTPKLINQIDEQIKLLQHSPEGWQLADGLLASQDPSVRFIAALTFQVKLNNEGSKLAAATAQAILARIVSWTVRLDRVGEGHLVQKKLCAALGTYFLQSSVQWPRPLLHIAASLAHGDFVSEDQLSASHDAINQYLPALGDSQIILLLWLSGQLATDGAKVDSTNPACERIYEQMQILVQDVSILIENALHRPASQISSDVKKECLVCFLNWVNYAQPMWPTKPEALEHLRRLVPGLSMLLLDPRLEHEAMDIFRDVLETYTTFFQPQHMTTLAEIIFNNVRPRMLQSLHEQEPEVISVAQFVIAYGIANIQQIVEQPENEIMSKAPLALIMAILEAPGYPGDDDEASLHSIEFWNTYIEYVNDITYSSADIETPLHWVSSARSTCMSLTHLLWQKMRTPDAETANEWTEAESEGFKEFRMDASDLMLSIYVFLGVEMLQSLVTIMLSALEHGQWQELEAALFAVNTLADNVLADQTAENTLTPVFSSSLYRIVGDFSQTMPTQARRTAVDTLGSYGAYIERHAEFLPDTLRFLFASLENPGLYLSAAKSIAELCSTCRASLTSELDGFLAQYNNFAQGETSEPYTNEKVIGAIAAIVQAVQPESAKARPLSALLDIIEGTLGNARDQSNPELLELWGASAIECLAAVGKNMQSEEDGPIDLSNDNTAPVDKKSFWQTTDGQAIQQRILSICQSALQLIPQNGEVVEGVCKVLKSGFVETEPGPFVFPPGYIIAFLEQCNPSTPNVESVLAMTCTLVQQYSRNNHPRIDDEVAKIYQKVVSMVQLLGEPSRDPGVAQSCIDVFNRMIGRYTNILMDTAGTGDMVAPILDFSLKAVDGADLMPKRAACGFWARLIKPEDKPADEVVRTRLAQVVAAYGPMLAQALMSQISGRGQRSELEQLCEPLKALLSTQPQSKQWIESALANKAALPAISEHVADSERQRFVAQLSAARGDTRRTRETVKHFYAACRNTITSYSTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJK4</accession>
    <name>N1QJK4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Fungal pheromone STE3G-protein-coupled receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_8462</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760106.1">
        <property type="nucleotide sequence ID" value="XM_016910361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJK4"/>
    <dbReference type="STRING" id="692275.N1QJK4"/>
    <dbReference type="GeneID" id="27907498"/>
    <dbReference type="eggNOG" id="ENOG502S44N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027592_3_2_1"/>
    <dbReference type="OMA" id="IPPLIWH"/>
    <dbReference type="OrthoDB" id="2874149at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004932">
        <property type="term" value="F:mating-type factor pheromone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14966">
        <property type="entry name" value="7tmD_STE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001499">
        <property type="entry name" value="GPCR_STE3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28097">
        <property type="entry name" value="PHEROMONE A FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28097:SF1">
        <property type="entry name" value="PHEROMONE A FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02076">
        <property type="entry name" value="STE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00899">
        <property type="entry name" value="GPCRSTE3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0589">Pheromone response</keyword>
    <keyword evidence="8 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="156"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="340"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF11985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="356" mass="39757" checksum="644BFE275766B9B4" modified="2013-06-26" version="1" fragment="single">YSRAMLFGTFSLLVAALIFPPLTWHFRNRNVGATVLVACAFYANLISFVNAMIWHNDDPTTWFSGTGLCDVEVKLQSYTMAALPAAISCILRALARVMDTERSTWGMTKTQKRRGYAIDLICCVALPLLQMPGSWIVQPFRYYVFGITGCHPALSISWPMLLLVMLQPLLWTLLAVYYSVLVVTRLIRYRLQFHSILANNQTTKSRFLRLYILCAICAFGYLPLHIYLIYTTIAQGFGPFSWKEVHHPTAYDWSAMVAAPTHGQITYDGFVWLAGGVVIFLIFGLGKDAVRMYRDGLLACGAGRIWPGLRHGSPRTSAAASTMTSMSSRARMLFSKRKNSVATTSSGTMDSFDSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1QK81</accession>
    <name>N1QK81_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fungal_trans-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_134121</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760351.1">
        <property type="nucleotide sequence ID" value="XM_016902610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QK81"/>
    <dbReference type="STRING" id="692275.N1QK81"/>
    <dbReference type="GeneID" id="27899747"/>
    <dbReference type="eggNOG" id="ENOG502RZ2S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006926_1_1_1"/>
    <dbReference type="OMA" id="GAQGLYW"/>
    <dbReference type="OrthoDB" id="3266505at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051711">
        <property type="entry name" value="Stress_Response_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540:SF6">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="273"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF12230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="637" mass="71130" checksum="C479B8F837917181" modified="2013-06-26" version="1">MAMAMATATIRLNAADESGRLHSSRCADSNLECIYPVRNKKVKVGQRYLNGLEAENKRLAALVSTLSTPGAAALATEQTPSEPRADNADRNPLIEERPWFVSFKNVDLPIHVGEAADAAFATRLRQAASSSAVSHIPRVHYMSDDTLRAFADQPIELPSASRLRFLVDVALKTTCKNWHISRPSVVQEDVQKLISNPTSCDWLLQCRIWALLALGEAFSSRCVLPNEPFPGAQYWARAMQLAHMPCERPKLDLVEVHLLMALYASSMNRRHTAILLASHALRLCIILGLHIEVGETQLRDPVMREHRCRLWWTAYRFDRLWASKIGWPPSIPDDSIEIGLPSDTGLSQEVRGDFEDFEYVIMSVRLARMLNNAVNTLYVRKRQPTSFSERVQAAVRALRDWADGLPDHLKLNVGDDAVTNPENHVLYLHLAFNQAVIVTTRPILLHLFKQRRPHLAHDSTPAQNFPDSALSLTTACIRCARQSMALLKQAWAEGTFPTFDYFHMQFLFSSATVLVLSALLQGSGWANDREDFLLAGTFLRQLERSGNFGAKEFCTHVDALKITLYENIDAAAGLGQGGVATVGMSNGTTTSSTPLPNPPLQDFLNHPEVDFNFMDQIGGTWIDWQDVFWPGMDLPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKG8</accession>
    <name>N1QKG8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Methylenetetrahydrofolate reductase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_149610</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759817.1">
        <property type="nucleotide sequence ID" value="XM_016905660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QKG8"/>
    <dbReference type="STRING" id="692275.N1QKG8"/>
    <dbReference type="GeneID" id="27902797"/>
    <dbReference type="eggNOG" id="KOG0564">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025841_2_1_1"/>
    <dbReference type="OMA" id="GLMPINS"/>
    <dbReference type="OrthoDB" id="16284at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004489">
        <property type="term" value="F:methylenetetrahydrofolate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00537">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.220:FF:000002">
        <property type="entry name" value="Methylenetetrahydrofolate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004621">
        <property type="entry name" value="Fadh2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053806">
        <property type="entry name" value="MTHFR_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00677">
        <property type="entry name" value="fadh2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754:SF1">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21895">
        <property type="entry name" value="MTHFR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MTHFR SAM-binding regulatory" evidence="10">
        <location>
            <begin position="416"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="351"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="369"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF11696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="670" mass="75222" checksum="E53BEABB19C8F18C" modified="2013-06-26" version="1">MDKITDKIAALPSDATYFSLEFFPPKTQQGFANLNARLSRMAHSLRPLFVNVTWGAGGSTSAKSLALAEVTQRELGLTTCLHLTCTNMSRKLIDEALEQAKVLGIRNILALRGDPPRSDEYRDDSLPDAGEDDSNKDFTWAVDLVRYIRKQYGDYFCVGVAGYPEGHSDQSHPEHQSIEHDLPYLVEKTKAGADFIMTQLFYDVNAYQKYEKRLREHESGIFRTIPIIPGLMPVQSYQIFRRTTKLSHASLPPEILRRFEAVKGDDEAVKRVGLDVLGEILDTMKHSEFPGPRGFHFYTLNLEKVVAQILERNSLIPPSTPTIGANLGDEATTFDEVDDFVIIAEAKKKQQRRRSSMANSGPRNRVIISSARESSTSSNRASSVYETFDHEAGVPREAINSRANTLAISEGEGSLGREATWDEFPNGRWGDARSPAYGQIDGYGVSLHVSVPEARRLWGEPKSVADISKSFARHLGGEIDTMPWSEESLQPETLTIKNELLQLINKGWWTVASQPAVNGVPSTDPVFGWGPKNGFVFQKPFVEFFIPNDEWQKLQSKLFEHPQITYFAGNAKSDFASNNAESVNPVTWGTFAGKEIITPTMIEAVSFRAWCEEAFGIWSEWQRIYKPGSESSRLLERIRKDYWLVSVIHHGYLEDGALWRDLLEDGSSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKS6</accession>
    <name>N1QKS6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Endoplasmic reticulum chaperone BIP</fullName>
            <ecNumber evidence="4">3.6.4.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Endoplasmic reticulum chaperone BiP</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Immunoglobulin heavy chain-binding protein homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SEPMUDRAFT_146735</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER. Is required for secretory polypeptide translocation. May physically associate with SEC63 protein in the endoplasmic reticulum and this interaction may be regulated by ATP hydrolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.10" evidence="4"/>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765911.1">
        <property type="nucleotide sequence ID" value="XM_016903830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QKS6"/>
    <dbReference type="STRING" id="692275.N1QKS6"/>
    <dbReference type="GeneID" id="27900967"/>
    <dbReference type="eggNOG" id="KOG0100">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005965_2_4_1"/>
    <dbReference type="OMA" id="VQRDIKH"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10241">
        <property type="entry name" value="ASKHA_NBD_HSP70_BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000009">
        <property type="entry name" value="DnaK-type molecular chaperone BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042050">
        <property type="entry name" value="BIP_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="660"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00069311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMF17790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="684" mass="74450" checksum="FA2654C80FE65E6E" modified="2013-06-26" version="1">MARYSGHKSSPARASVSSWMTAFYICAIFLAPMLFMGMIPSAHAQDTEKADTGVSGPVIGIDLGTTYSCVGIMKGGNVEILVNDQGNRITPSWVAWNDDERLVGDAAKNQFAANPHRTVYDIKRLIGRKFDDKDVQKDMKHFPYKVINKGGQPRVKVDVKGDEKTFTPEEISSMILGKMKEVAESYLGETVTNAVVTVPAYFNDAQRAATKDAGTIAGLNVLRVVNEPTAAALAYGLDKTDKERQIIVYDLGGGTFDVSILTVDQGVFEVQATAGDTHLGGEDFDQRIVDYFTKSYNKKHDTDITKNAKTMGKLKREVEKAKRALSSQMSTKIEIEAFHDGADFSETLTRAKFEELNNDLFKKTLKPVEQVLKDAKMKKSDIDDIVLVGGSTRIPKVQAMLEEYFGKKASKGINPDEAVAYGAAVQGGVLSGEAAASDVVLMDVNPLTLGIETTGGVMTHLIKRGTTIPTKKSQIFSTAADNQATVLIQVFEGERSMTKDNNQLGKFDLSGIPPAPRGQPQIEVTFELDANGILRVSAGDKGSGKSESITITNDKGRLSTEEIERMVEEAEKYAEEDKATRAKVEARNGLENYAFSLKNQVNDDEGLGGKIDEDDKEALMEAIKEATDWLEENGQTADAEDFDEQKQKLSDVAYPITSKLYGESGGAGGMPDYGDDEPSGHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKV1</accession>
    <name>N1QKV1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial import inner membrane translocase subunit TIM14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Mitochondrial import inner membrane translocase subunit tim14</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 13">Presequence translocated-associated motor subunit PAM18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SEPMUDRAFT_146752</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TIM14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765936.1">
        <property type="nucleotide sequence ID" value="XM_016903840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QKV1"/>
    <dbReference type="STRING" id="692275.N1QKV1"/>
    <dbReference type="GeneID" id="27900977"/>
    <dbReference type="eggNOG" id="KOG0723">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017633_13_3_1"/>
    <dbReference type="OMA" id="EPRMNKR"/>
    <dbReference type="OrthoDB" id="240298at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000001">
        <property type="entry name" value="Import inner membrane translocase subunit tim14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12763">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12763:SF28">
        <property type="entry name" value="GEO10507P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="J" evidence="14">
        <location>
            <begin position="51"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00075483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMF17815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="106" mass="11518" checksum="20F8A1AB88F9EFF7" modified="2013-06-26" version="1">MVTVLAVGVGVAAAAFFGRAGLVALRRARGGTSALGKAYYNGGFEKQMNRREAALILETSERGITKEMIRKKHRQLMLLNHPDRGGSPYLATKINEAKEFLEKGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1QL08</accession>
    <name>N1QL08_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_34110</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016766072.1">
        <property type="nucleotide sequence ID" value="XM_016908559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QL08"/>
    <dbReference type="STRING" id="692275.N1QL08"/>
    <dbReference type="GeneID" id="27905696"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_2_4_1"/>
    <dbReference type="OMA" id="MPEIPGA"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF9">
        <property type="entry name" value="P450, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="431"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF17951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="512" mass="57100" checksum="A6937208BEF6CAFF" modified="2013-06-26" version="1">MRGSSNDANRDVIGIFEIPGALPIAGHLLELGDDHATVCEKWSQKHQTSTFQIRLGNTRAVVINSFADCKRMLIGHQSAVIDRPTLYTFHGVISSTQGFTIGSSPWDESCSKKRKAAGQTLGRVAMKTYLPMFDLETTSIVRDVLRDCGGGGDKWLNVRPYLQRYALNTTLTLCYGIRMDSVWDEMLREILEVGSAISLLRSASENYQDYIPALRYLPNNEKTQRSKALRGRRDKYLDELLNKVREMIQQGKDRPCVSAAILKDEETKLSGVEVSSICLSLVSGGFETIPGTLTSCIGSLSTPEGQVFQEKAYEDIKRHYLSTEDAWLQSLEAEDVPYLNAIVKEAGRYYTVSSMSLPRKAAADIEWDRAIIPKGTMILINAQAANHEIEHFGPDAGEFNPERWLENVSPPRERPSVGLQHLSFGAGSRACSGQFIANRLLYTALLRIIASFKIVASKEEPPNTDYVDYNLLKSALVAIPRDFKVKFIPRNPEELATCLSKAEERTKDAYST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>N1QL32</accession>
    <name>N1QL32_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA (guanine(46)-N(7))-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_122430</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42708"/>
            <dbReference type="Rhea" id="RHEA-COMP:10188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10189"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.33"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.33" evidence="2"/>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765123.1">
        <property type="nucleotide sequence ID" value="XM_016901768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QL32"/>
    <dbReference type="STRING" id="692275.N1QL32"/>
    <dbReference type="GeneID" id="27898905"/>
    <dbReference type="eggNOG" id="KOG3115">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050910_3_2_1"/>
    <dbReference type="OMA" id="ERHPMFE"/>
    <dbReference type="OrthoDB" id="47276at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106143">
        <property type="term" value="C:tRNA (m7G46) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine(46)-N7)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00091">
        <property type="entry name" value="tRNA (guanosine(46)-N7)-methyltransferase TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417">
        <property type="entry name" value="3-DEOXY-D-MANNO-OCTULOSONIC-ACID TRANSFERASE/TRNA GUANINE-N 7 - -METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417:SF16">
        <property type="entry name" value="TRNA (GUANINE-N(7)-)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51625">
        <property type="entry name" value="SAM_MT_TRMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF17002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="175" mass="20047" checksum="FCF955EAE83920C5" modified="2013-06-26" version="1">MEIRTSVTEFVQDKARALRAQHAAAVASEEGGSEGAGKADYQNVSCVRANTMKFLPNFFRQQQLDKIFLCFPDPHFKQRKHKARIVSATLNSEYAFVMKPGGKVYTITDVEDLHCWMVEHLQGHPSFERVDDDEVEGDECVAIMRVETEEGKKVERNNGKKYVAVFRRLEHPLWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>N1QL69</accession>
    <name>N1QL69_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_129866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765153.1">
        <property type="nucleotide sequence ID" value="XM_016902316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QL69"/>
    <dbReference type="STRING" id="692275.N1QL69"/>
    <dbReference type="GeneID" id="27899453"/>
    <dbReference type="eggNOG" id="ENOG502SJ22">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1372962_0_0_1"/>
    <dbReference type="OrthoDB" id="5584477at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="1">
        <location>
            <begin position="39"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal-type protein kinase" evidence="1">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF17032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="199" mass="22367" checksum="8BB7A132F505D6AB" modified="2013-06-26" version="1">MEISEQGEWMLLETARAKNVKSEPYIQVLDDSHGMEKHERDRAALQRSPAELSEDNQKLGFDDLTLNCVVTSPLGQALDTFDTPKQMLTVLRDVIHAFAIVVPGRRHPPSGRQPAEHRDQGFIAIGILNGHNHTCRHGLESVFYVFLWIAICHDGQDSMRIPDGSQLHKWNGHGMVRDAEKQARGHAPGVFLDFCGERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>N1QM16</accession>
    <name>N1QM16_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-conjugating enzyme E2 2</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_145613</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="11">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764460.1">
        <property type="nucleotide sequence ID" value="XM_016903163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QM16"/>
    <dbReference type="STRING" id="692275.N1QM16"/>
    <dbReference type="GeneID" id="27900300"/>
    <dbReference type="eggNOG" id="KOG0417">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030988_13_2_1"/>
    <dbReference type="OMA" id="AEPHEDN"/>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031371">
        <property type="term" value="C:ubiquitin conjugating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006301">
        <property type="term" value="P:DNA damage tolerance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010994">
        <property type="term" value="P:free ubiquitin chain polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044395">
        <property type="term" value="P:protein targeting to vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd23813">
        <property type="entry name" value="UBCc_UBE2N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000020">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="12">
        <location>
            <begin position="4"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF16339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="153" mass="17224" checksum="1FD5B6E720FBBA03" modified="2013-06-26" version="1">MSAPLPKRIMKETERLQNEPVPGISATPRDDNARHFDVMVEGPGGSCYEGGVFQLELFLPDDYPMCAPKIRFLTRIYHPNIDRLGRICLDVLKNNWSPALQIRTILLSIQALLGAPNPEDPLNEAVAKQWKEDPALAIKTAREWTKQYAQAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNF8</accession>
    <name>N1QNF8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF1212-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_146693</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ThrE exporter (TC 2.A.79) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765844.1">
        <property type="nucleotide sequence ID" value="XM_016903801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNF8"/>
    <dbReference type="STRING" id="692275.N1QNF8"/>
    <dbReference type="GeneID" id="27900938"/>
    <dbReference type="eggNOG" id="ENOG502QPMM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007078_2_1_1"/>
    <dbReference type="OMA" id="KKRVGWH"/>
    <dbReference type="OrthoDB" id="413008at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010619">
        <property type="entry name" value="ThrE-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051361">
        <property type="entry name" value="ThrE/Ser_Exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082:SF4">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06738">
        <property type="entry name" value="ThrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="593"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="617"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="641"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="673"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="707"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="748"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="772"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="886"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="960"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/serine exporter-like N-terminal" evidence="4">
        <location>
            <begin position="485"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="288"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="335"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="420"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="852"/>
            <end position="874"/>
        </location>
    </feature>
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        <location>
            <begin position="72"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="188"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
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        <location>
            <begin position="353"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="429"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="860"/>
            <end position="872"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF17723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="991" mass="108276" checksum="73F25CE8787D6B47" modified="2013-06-26" version="1">MSTPVEEFPDPFGDSAELLSKYTPPSSGVMTSADGGSPSDRPLPSKTKKKVGFSNNADIAGERVPRASWVETSSPSGATSPASVSPHNAGSPEASGTNTPSIPHRRGSSGDLLIGDISKSHLPELSQQQTDQIRGSLVQLQHLSVPGRPRPALRRPRSPPRVEDPTEHIEGPDDIGERSKRQRATQRAYEEGRRVERMLSEPNSRNASPERNKRDESYMTDDIPLQDFNKFDDDDQTDVDEESSLAGLDKQRRAGAEAEAFKLVRRHTSARGAFRNHELGLDPGSAAVSGTVSGAATPGNVTPTEEQNYMEDYQPRPRQYRGGILGNLLKLYGDSSQHHGGRHAGQFSPRGLPEAHVRSVSGDHSRNTSAMSTPQHSPPESGASTPRRMSLNPWYMSKSRDRQSTASLAQLIGSSASLSSPGFTGLGEEVSRRLKEQQEQAKRESSKRPGLGKRKHSWSRFAKQQQAEQFRITNHIAETIARQKYLIGLCRALMEYGAPTHRLEEYMRMSARVLETDAQFLYIPGSMIMSFEDRDTHTSEVKLVKVAQGLDLGKLRDVHEVYKEVVHDKLGVEEATGRLKEIMRKKDKFNRPFRIFVYGLAAVCVGPFAFGARLIDLPIAFILGAILGVLQLYVAPSSDLYANVFEIAAAVITSFLARAFGSIKGGDLFCFSALAQSSIALILPGYTVLCASLELQSRSIVAGSVRMVYAIIYSLFLGYGITVGTAIYGMIDRHATSETTCRNTIPEYWFFFFVPGFSMCLIIINQAKWKQAPMMMIIAFAGYVVNYFSAKRFEGNTQVSNTLGALAIGVMANLYSRIGGRVENMALDFWETRLRPHWKLFRQRVFRVENRRSSPKSMEEGSSSYGGSTRSNSDAESIFKPAARRVGYSLAAAAMLPAIFVQVPSGLSVQGSLVSGLASANQINGNAANGTQVANSSTITSSSATTDGLNSIAFTVGYSVIQVAIGITVGLFLSAIVVYPFGKRRSGLFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNH4</accession>
    <name>N1QNH4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">40S ribosomal protein S11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_146355</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765410.1">
        <property type="nucleotide sequence ID" value="XM_016903596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNH4"/>
    <dbReference type="STRING" id="692275.N1QNH4"/>
    <dbReference type="GeneID" id="27900733"/>
    <dbReference type="eggNOG" id="KOG1728">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073626_0_1_1"/>
    <dbReference type="OMA" id="DYEKCPF"/>
    <dbReference type="OrthoDB" id="16824at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00364">
        <property type="entry name" value="Ribosomal_uS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.1000:FF:000001">
        <property type="entry name" value="40S ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_uS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028333">
        <property type="entry name" value="Ribosomal_uS17_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_uS17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032440">
        <property type="entry name" value="Ribosomal_uS17_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03630">
        <property type="entry name" value="uS17_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744:SF9">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16205">
        <property type="entry name" value="Ribosomal_S17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS17 N-terminal" evidence="5">
        <location>
            <begin position="8"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF17289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="161" mass="18520" checksum="5DA2BBBCB7360355" modified="2013-06-26" version="1">MATELTVQSERAFQKQPHIFLNSKSQKKSTRVGKGGRRWYKDVGLGFRTPKTAIEGQYIDKKCPFTGLVSIRGRILTGTVVSAKMHRTIIIRREYLHFVPKYSRYEKRHKNLAAHVSPAFRVSEGDQVTVGQCRPLSKTVRFNVLRVLPRTGKQVKQFTKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNI1</accession>
    <name>N1QNI1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_104984</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765899.1">
        <property type="nucleotide sequence ID" value="XM_016900561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNI1"/>
    <dbReference type="GeneID" id="27897698"/>
    <dbReference type="eggNOG" id="ENOG502ST5U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133420_1_0_1"/>
    <dbReference type="OMA" id="CGKQSKD"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031632">
        <property type="entry name" value="SVIP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15811">
        <property type="entry name" value="SVIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0519">Myristate</keyword>
    <keyword evidence="2" id="KW-0564">Palmitate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="57"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="125"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF17778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="171" mass="17820" checksum="60754A2ECA91DEB8" modified="2013-06-26" version="1">MYLQSIRYLRRLRAEQIFVNTQVLLYTGLRHGIPFPTTDRYRMGNCFGKSSSNANFQGEGRTIGGGAAAGGGASPAHAPRPAAAPPPKVTGPGRTLGDNTAPAPSSDAQTPASAAARAAEERLKAAQGKGKLGKQLDAQKSQTQKDTLASTARENVAAREADAAAQARAYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNL9</accession>
    <name>N1QNL9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_146789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765994.1">
        <property type="nucleotide sequence ID" value="XM_016903866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNL9"/>
    <dbReference type="STRING" id="692275.N1QNL9"/>
    <dbReference type="GeneID" id="27901003"/>
    <dbReference type="eggNOG" id="ENOG502QQYZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025005_3_1_1"/>
    <dbReference type="OMA" id="MDYIGNS"/>
    <dbReference type="OrthoDB" id="3645574at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF37">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="112"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF17873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="517" mass="60385" checksum="031273890657F349" modified="2013-06-26" version="1">MTDVVIQTRKGPLTEAQALQSDMDMIPALCQLDPLFDFREHLDSRRAQIERLVSRHLGIPKNHVVLGVEREWISGSFNICLPVHIDNSRKPSLPRKAMVRFPLLFNIGESFSPGSADEKLRCEAATYIWLRENCPDVPIPRLLAMGFPGAQSFTAVENESTLNRIRWLLRRGVSWWRGEMLAPFFAHRRDQLADLGYLLIEYVQDGEMLWRSWQDHRHDEHRRSNLYRSLAKIMLDLAQVPQPRIGSWTMNDNGVLSLTNRPLSDLTFFWNRHQVPTGIPRDLTYTSTEPYVHDRLAYQDLRMRHQPNAILSEADGLYQLSALSALRIMLPRFWDQNSRNGPFVFSFNDLHQSNIFVDEDWNVTSIIDLEFACVQPIQMTCIPTWLNGRGVDEQEGPDLEDYSQLYHHFVAILEAEEKSRRLSHTYSHQLREDWKTGRLWYIKALDSLNGFPAIVEQHLRPKFFEKFDWKIDGLALARLWDENVLDFINKKIEDRDQYEVRIKEMFAKAGRAQQVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNQ2</accession>
    <name>N1QNQ2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase 2A activator</fullName>
            <ecNumber evidence="8">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Phosphotyrosyl phosphatase activator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_153777</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the PTPA-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="8"/>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016766084.1">
        <property type="nucleotide sequence ID" value="XM_016907528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNQ2"/>
    <dbReference type="STRING" id="692275.N1QNQ2"/>
    <dbReference type="GeneID" id="27904665"/>
    <dbReference type="eggNOG" id="KOG2867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030733_0_0_1"/>
    <dbReference type="OMA" id="SWIKINA"/>
    <dbReference type="OrthoDB" id="16120at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008160">
        <property type="term" value="F:protein tyrosine phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04087">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1150:FF:000002">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004327">
        <property type="entry name" value="Phstyr_phstse_ac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043170">
        <property type="entry name" value="PTPA_C_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037218">
        <property type="entry name" value="PTPA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012:SF5">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A ACTIVATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03095">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016325">
        <property type="entry name" value="Phstyr_phstse_ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140984">
        <property type="entry name" value="PTPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0697">Rotamase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF17963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="426" mass="47115" checksum="1CE26B4C3E9B4799" modified="2013-06-26" version="1">MPTATPLPDSQIPTNPPDLSKKLPKLVPRRSKPSEEAASNPPPPTPALAAAPNLQDHKYQKPARRILSQRDHELFLASPTHDLIVSFVFHLSDSVRNTTIRNVQSSDQAQDPSILALLAVLDEAEELRKKTPALDTGSRFGNPAFRDFLDAVDTALPSWHTKLGVTSSSAQSEVSTYLASAFGNGSRIDYGSGHELNFILWLLCLRQIGILHQHTFPALTLLVFPRYLRVMRDIQSTYYLEPAGSHGVWGLDDYQFLPFLFGASQLVGHKHIRPLSIHNELILEECSPDYLYLDQIQWVNATKTVQGLRWHSPMLDDISSAKNWAKVEAGMKKMFLAEVLGKLPVAQHFLFGSLLSAAEDMSRDVEQLVGEEDVGEVEVTVEGMKHTHSANRWGDCCGIKVPSAVGARQEMSKMGGGGGLRRVPFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNU1</accession>
    <name>N1QNU1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_146586</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765730.1">
        <property type="nucleotide sequence ID" value="XM_016903749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNU1"/>
    <dbReference type="STRING" id="692275.N1QNU1"/>
    <dbReference type="GeneID" id="27900886"/>
    <dbReference type="eggNOG" id="ENOG502QPVD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028452_3_0_1"/>
    <dbReference type="OMA" id="TWGFAYG"/>
    <dbReference type="OrthoDB" id="546893at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050375">
        <property type="entry name" value="MFS_TsgA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702">
        <property type="entry name" value="L-FUCOSE-PROTON SYMPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702:SF3">
        <property type="entry name" value="PROTEIN TSGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="379"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF17609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="493" mass="51819" checksum="0A8A89F14196E5ED" modified="2013-06-26" version="1">MAGGGVPTGAPTIAGGPLSGKQLIYPLSLVISLFFLWGFSYGLLDVLNKHFQTVLNITRLESTGLQVMYFGGGYLCFSPIAAEVMKRKGYKTTILMGLGLYSLGAIMFWPTAHYASPDNTIAAFGGFLACTLVIACGLATLETAANSYAVVIGHPASASARLQFCQSWNGIASFIGPLIASKAFFSGDNINSLTNVQFVYLAVSCAGVAVAVLFFFSKLPEVPEAALRSASIVATDSELGFNDGLVAQKPLYKEYNMMFGFVAQFCYVGAQVTCATFFINYANENGGYSTSAASRMLSYALITFTVGRFIATGLAVIFESNFLLVIYSCCAIALSAYVSAGRGSAAVGALIAIFFFMAPCYPAIFTLGTANLGKNTRRGAGILVMGVSGGAVFPPIQGAIADSASTRISYVVPLVGFVVVLGYCASHWVRHGMHILRLKGEPVVATSMEGGAVGGAVQTVHYDEKRLSVVEVETAARRSSIGNVDGTTGGIRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M3AV02</accession>
    <name>M3AV02_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_151004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF09901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758022.1">
        <property type="nucleotide sequence ID" value="XM_016906537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AV02"/>
    <dbReference type="STRING" id="692275.M3AV02"/>
    <dbReference type="GeneID" id="27903674"/>
    <dbReference type="eggNOG" id="KOG1674">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013692_3_0_1"/>
    <dbReference type="OMA" id="NDRQHDH"/>
    <dbReference type="OrthoDB" id="1060854at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20558">
        <property type="entry name" value="CYCLIN_ScPCL7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF94">
        <property type="entry name" value="PHO85 CYCLIN-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="494" mass="54291" checksum="E45926BFD1401A83" modified="2013-05-01" version="1">MGSLVIDAATSFFSQQQSHHAHPHISPSHPQHALYRETPRTGSTSKRSRSQSNSGSDHMSEPAQRAPSSSAAQRHSDHVRSGEPRAASQRSAPRPQSPTLGASTLPPPPADESQTDAQTDSIHTTPSSRSSRPRKIKVRDLDHIRTFASENMRDFSEIRSRSRSRSRAAEDNSPEYEISEMKVEHIIEMVAGLLTKITTTNDKQHEHLHRAPPSMNEASHLNQQTTSVLAFHGKNVPSITILSYLSRINKYCPTSYEVFLSLLVYFDRMTERVNAGPMQCLHQANQQAVKANAKASRSGSAESLDPDRMEGVIAATPSGTQQATPPYSGGLERPSERGIPGTPHSRPNNPEADSLTPPPPPSSTEPSTHLDMDPFNLSHFFVVDSFNIHRLVIAGVTCASKFFSDIFYTNSRYAKVGGLPLPELNHLELQFLLLNDFRLSIPVEEIEAYGTMLVEFYAREVVAQKRAAEAAASMNERSLSESSTESTATVRAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M3AVV0</accession>
    <name>M3AVV0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">R3H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_151207</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NFX1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758332.1">
        <property type="nucleotide sequence ID" value="XM_016906672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AVV0"/>
    <dbReference type="STRING" id="692275.M3AVV0"/>
    <dbReference type="GeneID" id="27903809"/>
    <dbReference type="eggNOG" id="KOG1952">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005714_2_0_1"/>
    <dbReference type="OMA" id="CPHPCDS"/>
    <dbReference type="OrthoDB" id="6512771at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06008">
        <property type="entry name" value="NF-X1-zinc-finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.50:FF:000006">
        <property type="entry name" value="NF-X1 finger transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034078">
        <property type="entry name" value="NFX1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000967">
        <property type="entry name" value="Znf_NFX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12360">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR, X-BOX BINDING 1 NFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12360:SF12">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR NF-X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01422">
        <property type="entry name" value="zf-NF-X1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00438">
        <property type="entry name" value="ZnF_NFX"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="R3H" evidence="11">
        <location>
            <begin position="846"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="131"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1132"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF10211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1194" mass="130294" checksum="35219410DAEED1CA" modified="2013-05-01" version="1">MDTGAPADSEVTHRRRQPRRARGSRRGGGDDAALAFRPASIAPAAPVHDRQTIPDGVGQRGGRGGGGGGGRGRGRSGRGGGGQAPQNRTTVNGRTFGGALTRADTTTSQTSTGNLQAAAPVFVPGQLHVQNVPLKQPIERDPRSHRQTKQRRMSKSQAPDIATRTHEDIDNRHYECAICTSEVLRNSKVWSCHTCWTVFHLKCIKQWSSNAGAAAAQSNTNGEPQMRQWRCPGCNLPKDDLPHSYSCWCEKETEPRPLQGIPPHSCGQTCGKERPRKCPHPCQLTCHAGPCPPCTHMGPTKTCYCGSHESTKRCMETNYESGWSCGEVCGSVMACGEHTCPQACHDGPCGPCEIRLPARCYCGQMEKDVLCSDRGLPVESNRKHSLSDLAVTESATDLQGSETVLETWTGVFNCGSTCGRTLDCNHHQCVKKCHPQDADSGHCPRSPDVVTHCSCGKTPLHELSDAPRTSCEDDIPSCSKPCDKSLPCGHPCPQVCHVGDCGSCLRTVTISCRCGRSSHTTMCHQGRDEPPQCMRICRSTLNCGRHMCDEHCCAGEQKARERQASRKKGRPFGSAPRAAAEGYEAEHICTRQCGRPLKCGNHSCEELCHKGPCGSCREAIFDEITCHCERTVLQPPLPCGTQPPPCRYACERPKSCGHPQVAHNCHSDEDTCPKCPFLTPKMCMCGKKALKNQQCWLRDVSCGNVCGQKLKCGVHFCRKQCHRKGQCEDAGGKACAQPCGKEKKICGHPDEAPCHAPFGCKEIKPCNSKIFITCECQAQKQEIKCGASSTTEGNNLKSLPCTEDCARLERNRKLAVALNIDQSTHVDGGDHIPFSTDTLDLFAAHPKWGQVQEREFRVFAASDDEKRLRFKPMSAQQRSFIHSLAEDFGLDSESLDPEPHRHVMIWKTPRFVSAPNKTLADSLRLRQQAQRSVYASTNASDNEGAPVKSASKTFEPFNSFRIIKPRFGLTIEEVRSEVETVLRTAYPFTFDIEFLPSEDVVLKAISRTLSAQDLERMLLNLKDPLGTKIADRSYGSMQLCTTDSSLNITRFESDGMGSDGWSRVAAKKSAPRIALQSNTYGTTNAFSALSGGKVTFAKKAPLAKVVKRRPAPVVDDWEAAEVEEEEKERIAYASASEGEALGVERSRDPLPLEGSSSDESVAAETAVAKVDETIDEGAETRDWAEGVTLAEQTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M3B2E9</accession>
    <name>M3B2E9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">2-Hacid_dh_C-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_149052</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762048.1">
        <property type="nucleotide sequence ID" value="XM_016905309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B2E9"/>
    <dbReference type="STRING" id="692275.M3B2E9"/>
    <dbReference type="GeneID" id="27902446"/>
    <dbReference type="eggNOG" id="KOG0068">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_1_3_1"/>
    <dbReference type="OMA" id="CLEECHC"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050418">
        <property type="entry name" value="D-iso_2-hydroxyacid_DH_PdxB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43761:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE CATALYTIC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43761">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G13630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="5">
        <location>
            <begin position="43"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="6">
        <location>
            <begin position="158"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF13927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="363" mass="39838" checksum="A7707FA224A5F029" modified="2013-05-01" version="1">MASNPPDTSTGWLKQEPPKLPPGYQKHHIVFLEAVHMPLAELPFEHTIDVYSRTLPHEIAERIKPATIVISNIIDVKPSDMDHAPHMQLLAILATGMGWVDKEYCARRGISVVNGPGANIDAVSEHFLALQLASRKRIGVVDHTVKHSDEWRQTNSLTKKVWPSGPPLGITQETLGILGYGALGKNIERLAKAIGFKEVLIADRRGARELREGRTPFEQVIQQSSTIVLVLPREPDTINLIDEAELKAMRKDALVINVARGGIVNEAALAKALKEGWISGAATDVLDTEPGGPGSTPLLPDLSKGEEAVPNLLITSHVAWFAQATISNLQRINRDAMTAYVEGRMYDPKEKHVVAVHDGKIWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M3B558</accession>
    <name>M3B558_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spo7-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_146928</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF14897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763018.1">
        <property type="nucleotide sequence ID" value="XM_016903966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B558"/>
    <dbReference type="STRING" id="692275.M3B558"/>
    <dbReference type="GeneID" id="27901103"/>
    <dbReference type="eggNOG" id="ENOG502QTI4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032659_1_1_1"/>
    <dbReference type="OMA" id="ENWDEYR"/>
    <dbReference type="OrthoDB" id="5599171at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071595">
        <property type="term" value="C:Nem1-Spo7 phosphatase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005605">
        <property type="entry name" value="Spo7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28249">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN SPO7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28249:SF1">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN SPO7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03907">
        <property type="entry name" value="Spo7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF14897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="535" mass="60532" checksum="DEB79EE17EE3410B" modified="2013-05-01" version="1">MSDPIDRIVKGAPPPDVSAEQLAANARASTSSKRNSITAPIPPDASPQQQQQSYSNDPRDALPSSPPQIYLNLLIMESSLRLQYISLRTRLRLHLLLFIGLVAWTVTFTYLLFFRPREDGSGVGGSVYWVLETGEKMGWCSGCVTLLLFWGTGMYERGVRWPRKFIGTTNRGLRGFNLKVVLVRAGMLREIVSWLAILDPAGWFQEERVHFQIVPKDIESVAGDAQPGKDHLHWNAHAAKYGLLEEDIAPAGDVLRILLLPKPFSPDFREGWDTFRLEYWERENARRAQLRAVVRARKREVAKREGGWFWWTGWRGWQNVTMNPFRRRKTRRQQELERLALREKISTEGSKARVFPGGEAARRRKGSLLQGQQPMSRSGSHSRTNSRASTPGPDGDSRPSTATKEGRTRRGSSASSVGSRRPRKLASLNEPSRLSATETLMYMNDDPSRDTTPDGQDRPLRNAARPTRRGSSKRDSTISTGSSDLDSRDNSFDTRSTETVNTARHSHQHHHSTRQTSSMEPIFAEEIKQEPEEHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M3B5F2</accession>
    <name>M3B5F2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sugar_tr-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_161276</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763123.1">
        <property type="nucleotide sequence ID" value="XM_016907926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B5F2"/>
    <dbReference type="GeneID" id="27905063"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_25_1_1"/>
    <dbReference type="OMA" id="WATYLFY"/>
    <dbReference type="OrthoDB" id="648285at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000119">
        <property type="entry name" value="MFS monosaccharide transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF73">
        <property type="entry name" value="METABOLITE TRANSPORT PROTEIN YDL199C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="348"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="437"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="473"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="502"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="530"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="598"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="191"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="40"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="102"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="706"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF15002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="734" mass="81268" checksum="978CDDEC38859F9B" modified="2013-05-01" version="1">MGWDEMGEICRRSSGSTNRRHRGALSLGSATHYFGTIPLHTFSSSSGRRHSSESYNEKDRERLRRRSNSFEDDDDDDDFSLWSDTGDLVDQLADEEDPLAARLRDSASVESPRKSRKHRSSKHVRYASNHSHGEKRHGQSGFVTRKEDIVVPTPPRIPLSWGQRLLARTMAPGDGPARMHGLHGKKLVYFLSIFVSLGVFLFGYDQGVMSGIITGPYFKDYFNQPTPAEIGTMVAILEVGAFISSIAVGRIGDLLGRKKTILYGALIFVVGGAIQSFANGMPMMMLGRIIAGLGVGALSTIVPVYQSEISPPHNRGKLACIEFSGNIFGYMCSVWVDYFCSYIDGHWAWRLPLLMQVVMGGLLAVGSFLIVESPRWLLDNDHDEEGIVVIANLYGKGDIHNQKARDEYREIKMNVLLQRQEGERSYADMFKRYYKRVFIAMSAQALAQLNGINVISYYAPLVFEQAGWVGRDAILMTGINGLTYLASTIPPWYLVDRLGRRFILLSGAVAMVISLSAISYFIYIDIHLTPTLVVIFVMIYNAAFGYSWGPIPWLYPPEILPLSIRAKGASLSTATNWAFNWLVGEMTPILQQAIKWRLYLLHAFFCAVSFVVVWFIYPETANVRLEDMNSIFGDATTVAPTPETLAEAASLFGDRSPVPSFTLGDDQPGGDIPDLDLQPPEVDIKDGKPMLGNGKGGEGVAGWLSNVADKMKRGGEDSNGGGSGKYKRVGQDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M3B5Q7</accession>
    <name>M3B5Q7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-phytase</fullName>
            <ecNumber evidence="2">3.1.3.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_154027</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.8" evidence="2"/>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763253.1">
        <property type="nucleotide sequence ID" value="XM_016907541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B5Q7"/>
    <dbReference type="STRING" id="692275.M3B5Q7"/>
    <dbReference type="GeneID" id="27904678"/>
    <dbReference type="eggNOG" id="KOG3720">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030431_3_1_1"/>
    <dbReference type="OMA" id="SWPPFTS"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016158">
        <property type="term" value="F:inositol hexakisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF110">
        <property type="entry name" value="2-PHOSPHOXYLOSE PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF15132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="499" mass="54930" checksum="69731B59205BCFA0" modified="2013-05-01" version="1">MSTLLPRSPYSESELAQLYPPTLQLCQVQVLLRHGERTPVSSRFKNAGLNGTWNYCRAANELKATILAADGSWDTLAWKRRMETFGVEDTPKLAAGSRGDIDAVCQPGELTDRGRETTLALGQRIRTLYVNQLAFLPAFLDEQNKSNVSLRATPIPRALESVQQAFVGLYPAASRSPGLLPPAIVQRAFQDETLFPNEGACKRFAELAHQFADRAANIWNDSNEMKYVNQKIGKWMPKESPIIKVDSHPRLSGVMDSINATLAHGLDTKLPAAFYDETVRANIDRICVEEWFAGYQESAEYRKLGIGGLIGDVTQRMVEQTIGVPKEGQGEPLKFSMSGCHDTTIASTLAALGGFDYEKNKWPNFTSSVAFELFKSKDTSMSPPSSNGKSWLSSLFSSSSSKANVDTASRAPLNSMPQSTQHKLEGHYVRLRYNDQPVTLPFCKAPGRHLEGDETFCTLKAFKEAADMVTPKDWKLECKSNLGASAFPAKIEPPPGVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M3B5R5</accession>
    <name>M3B5R5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_147106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763263.1">
        <property type="nucleotide sequence ID" value="XM_016904084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B5R5"/>
    <dbReference type="GeneID" id="27901221"/>
    <dbReference type="eggNOG" id="ENOG502S0NF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033551_0_0_1"/>
    <dbReference type="OMA" id="NHAWLAL"/>
    <dbReference type="OrthoDB" id="5552418at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF15142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="392" mass="42674" checksum="EAE5DD1764FD1150" modified="2013-05-01" version="1">MDYNDPSRRQYAQQTSYAAQQSQSGSTQPGSQFNTPGGSVERFRQSSGYLQQSPQAVASTARASGDAQVYAFPQSSQYGAGPSATAQSMQYSSDLHGADAPRQSDSAHYQQYGSNVMYGMAQSTQQATQSPYDPVSRYSQRPGTASETLASQFGASQTAAAQYYLAGQSLPSATVPELAASQLPSQYQPSAYAAAGPSSTYTSTMMDPTQSGAYSYAATANQYTPSSAQSVDQAFANYQSQIRTLFTSVREGALREVGGLLMDVSHYLLGNAEALGLTRDDDNLHDERIRLWDEFNRAWLVTLEKQRELTQEYLQNQGLREPLSIMSVQILEHLSRELVRLCDSVEKHGLVDYQMGVAEEEIMDLLIRCLSLLDPDSATTGAESSVSASRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M3B6E8</accession>
    <name>M3B6E8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prefoldin subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_147275</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763488.1">
        <property type="nucleotide sequence ID" value="XM_016904193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B6E8"/>
    <dbReference type="STRING" id="692275.M3B6E8"/>
    <dbReference type="GeneID" id="27901330"/>
    <dbReference type="eggNOG" id="KOG1760">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130032_0_0_1"/>
    <dbReference type="OMA" id="KFGRAIN"/>
    <dbReference type="OrthoDB" id="10250441at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23165">
        <property type="entry name" value="Prefoldin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000005">
        <property type="entry name" value="Prefoldin subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016661">
        <property type="entry name" value="PFDN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21100">
        <property type="entry name" value="PREFOLDIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21100:SF9">
        <property type="entry name" value="PREFOLDIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016477">
        <property type="entry name" value="Prefoldin_subunit_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="39"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR016477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF15367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="136" mass="16021" checksum="2BB6AE3C40C1A1F0" modified="2013-05-01" version="1">MLSRRMLSREEEAEIGEEKEVRKEDQDKINRFSRLHSREKGLEEELKVKQKDKEDLEEISSELELADEEEKVPYKIGDSFFNLPVPEVQELLSAAVERIDREVSTVEEKLGEYREEMQTLKSELYGRFGKSINLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M3B6T7</accession>
    <name>M3B6T7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_139226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763643.1">
        <property type="nucleotide sequence ID" value="XM_016902898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B6T7"/>
    <dbReference type="STRING" id="692275.M3B6T7"/>
    <dbReference type="GeneID" id="27900035"/>
    <dbReference type="eggNOG" id="ENOG502S5WH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094649_1_0_1"/>
    <dbReference type="OMA" id="NEEYAGM"/>
    <dbReference type="OrthoDB" id="5565730at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41390">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41390:SF1">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 213 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF15522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="214" mass="22843" checksum="634512BE74988BC9" modified="2013-05-01" version="1">MAEQQRRRALAARDPTADNIETALKVGVATAGVGFMFGGAVGILKNLPLSLSAGVTSLQSFGLGAVFTFTRLSVIQAWTTELQTPTPGDLIKATAIAGAFSGGSLGALFRGRKNVIPGAIMWCIFGATGQFMYNRRTLPAQRAEVKGPGFWQSMSDKSWTPFKVLSNEEYAGMLKEKLLRVEAEISIIDDKIAAMKGQQQAEVAREGEAAAKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M3B748</accession>
    <name>M3B748_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">60S ribosomal protein L12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_161799</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763788.1">
        <property type="nucleotide sequence ID" value="XM_016907958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B748"/>
    <dbReference type="STRING" id="692275.M3B748"/>
    <dbReference type="GeneID" id="27905095"/>
    <dbReference type="eggNOG" id="KOG0886">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074237_5_0_1"/>
    <dbReference type="OMA" id="QPPHDVI"/>
    <dbReference type="OrthoDB" id="1478556at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.250:FF:000002">
        <property type="entry name" value="60S ribosomal protein L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1550.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="entry name" value="Ribosomal protein L11/L12, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_uL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_uL11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_uL11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_uL11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_uL11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_uL11_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="Ribosomal L11/L12e N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL11 N-terminal" evidence="8">
        <location>
            <begin position="13"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL11 C-terminal" evidence="7">
        <location>
            <begin position="74"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF15667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="165" mass="17696" checksum="C873AB889ED16F3A" modified="2013-05-01" version="1">MAPKFDPSEEKIIHLRATGGEVGASSALAPKIGPLGLSPKKVGEDIAKATGDWKGLRVTVRLTIKNRQAAVSVVPSASSLVIKALKEPPRDRKKEKNIKHTKSIPLDEIITIARTMRHKSMAKDLKGTVLEILGTAFSTGCQVDGRSPKAVSDDVRAGEIEIPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M3B8B5</accession>
    <name>M3B8B5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_61629</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF16087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016909571.1"/>
    </dbReference>
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    <dbReference type="eggNOG" id="KOG0197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OMA" id="FYLPRHW"/>
    <dbReference type="OrthoDB" id="1668230at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF288">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="2"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF16087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="245" mass="27541" checksum="6D5B9A9301D89D74" modified="2013-05-01" version="1">MGDDLEVIAGGSTGLIKLRTDNSFVEKAPHPNDKTVEANLEDLRREYVAYSRLPRHPRVLQLHSHSTPQRLVLPYLRNGCLRDFLRYTSSSSSSSRRLQFAADAAESLSILHSVQIIHGDINSWNFLLTDDFRLCIIDFSGSTIDGSAGSGFEGFRYCLPRSFHDPSTVRTDLFALGSLLYEIMTGETPYQSCEDQEVEEYFRKGIFPTTKDVPLLGSVMLGCWRGAYESAEAVYEDIKKQQEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>M3B8G7</accession>
    <name>M3B8G7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_27748</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF16147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764268.1">
        <property type="nucleotide sequence ID" value="XM_016908433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B8G7"/>
    <dbReference type="STRING" id="692275.M3B8G7"/>
    <dbReference type="GeneID" id="27905570"/>
    <dbReference type="eggNOG" id="ENOG502SP7J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007003_8_1_1"/>
    <dbReference type="OMA" id="RGGECHY"/>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053187">
        <property type="entry name" value="Notoamide_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256:SF3">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF16147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="375" mass="41921" checksum="FA2B6370A3DA6C49" modified="2013-05-01" version="1" fragment="single">LQSLKRQAVAAACDNCRVKKVKCNGARPCSYCLRRDIECIFETTVPSETPQQARKRRFDETTVRNSNFQQLWDLLAGDNEARAVAIFRRIRRGENLESLVDHLQHGGAPSSPLLSAGQRLQFKFISCLIESTATLLQVEGTASAFLANTVINIPSYDAYTPFRDRIVQLDDLGDLLTAANRPAAIHANSHHSPIISRSARGPLYWVPASPWLPGTSDQEASHLISLFLCFLNHTWRFVETDLFLRDMRSGNLASQYCSPLLVHAMMALASLNSDLSEEHFQPGHSFEKGMRYHDEAVRLSTAAMSEPSITNIQGLAILALECLLRGNDLQGEIHLSAASTLNRWLPLPVRSADMTEQESEYYVARACVWWMAVHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M3BPD5</accession>
    <name>M3BPD5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_159574</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF08028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756149.1">
        <property type="nucleotide sequence ID" value="XM_016907857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BPD5"/>
    <dbReference type="STRING" id="692275.M3BPD5"/>
    <dbReference type="GeneID" id="27904994"/>
    <dbReference type="eggNOG" id="ENOG502QPVD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028452_3_1_1"/>
    <dbReference type="OMA" id="FMTLFFE"/>
    <dbReference type="OrthoDB" id="546893at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050375">
        <property type="entry name" value="MFS_TsgA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702">
        <property type="entry name" value="L-FUCOSE-PROTON SYMPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702:SF3">
        <property type="entry name" value="PROTEIN TSGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="357"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="429"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="445"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF08028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="469" mass="50763" checksum="BA97574515CCE084" modified="2013-05-01" version="1">MTIFKKQSLKTGNASHPLCLVTILFFLWGFSYGLLDTLNKHFQNTLGITRARSSGLQAAYFGAYPLASLGHANWLLRHYGYKVVFIWGLCLYGIGALVAWPCILHKSFGGFCAAIFIIGNGLGSLETAANPYITVCGPPRYAEIRINFSQAFNGVGTVVAPVLGSYVFFKKVDDNTDSLKTVQWVYLAIACFVFGLSVVFYFSPIPEITDADMAYQVEETHAGDNEQSFWKQHRLFHAAFTQFCYVGAQVGIASYFINYAHEAGRSDVAASRLLAGAQGTFTLGRFVGVALMKYFKPRWIFLAYMTGCIVFVSPAIGLKHGNAGIAMLYIVLFFESICFPTIVALGMRGLGRHSKRGSGWIVGGVCGGAVVPPALGAAADQVGTARAMSVALAFFLLAWAYPFAVNFVPSYRDPADKLGSAEIGMKGTLPRKDVEAGSDGGVPSEEEKGGAVHHELEAQGEDKIMETKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M3BU07</accession>
    <name>M3BU07_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoinositide 5-phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_151170</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptojanin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.36" evidence="4"/>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758266.1">
        <property type="nucleotide sequence ID" value="XM_016906646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BU07"/>
    <dbReference type="STRING" id="692275.M3BU07"/>
    <dbReference type="GeneID" id="27903783"/>
    <dbReference type="eggNOG" id="KOG0566">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003016_2_1_1"/>
    <dbReference type="OMA" id="HPCHELR"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043813">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000029">
        <property type="entry name" value="Inositol polyphosphate 5-phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF257">
        <property type="entry name" value="PHOSPHOINOSITIDE 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SAC" evidence="10">
        <location>
            <begin position="99"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="950"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="989"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1034"/>
            <end position="1048"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF10145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1153" mass="128276" checksum="D3D7A7D2F54528FC" modified="2013-05-01" version="1">MQGYRTLSSLSIQGTLGLVTVNGDVFLCVVNSSKKAAEVRPGERVNKIMGVDFHCLTSNQYDHLLHDQVNPFPTDHLDADAYDRGGHRDALLEHPCSKLKKLLSEGTFYYSADFDLTKRVQDRPAETTTVSIDSLDGGFLWNTYMIQPLVDFRSRLSGREKAALDESRILTSAIRGYANTVAIPAASSPARGETSGLPSNMTLISRLSCRRAGTRFNSRGIDDDGNVANFSETETIFTTDRLCYSYVQCRGSVPLFWEQASGLPGQQKIQITRSAEATQPAFDKHMQRLSETYGDIVAVNLLSEEKPQETQLTRLYMHHIDNSLLNTHAKGAESEHKHVIPVNYDFHAETRGPNGYQAASGIRRSIEKAVDAFEYYLSEDAPGIVNQNGRKHSAIVQNEILKQAGVFRTNCLDCLDRTNLVQTIISQIAFELFLEQRREPRPTSDFWARHGILWADNGDELSKIYAGTGALKSSFTRSGKMSIAGTLADIRKSAQRLYINNIEDPRKQTIMDMLLGRLVGQTPVHLYDPINDWVTIELGRRYREYTSTDKINIWAGTFNLNGRTHGLGEDLSPWLCPEVEKEYRSPEIVAVAFQEIVDLDVNQILSTDPLRRSMWETAVRDTLNRKAQKYGGEEYVMLRGGQLVGASLSVFVKVSVLPMIRNVEGAVKKTGLSGMAGNKGAVAIRMEFADTSICLVTAHLAAGFGNYDERNQDYRTISSGLRFQRNKCIDDHDTAIWFGDFNYRIGLHNERARQLIKMRDLGQLYENDQLNLQMIGGKVFLHYSERTPTFLPTYKFDPGTDEYDTSDKARIPAWCDRILIKGDNIQQLYYDSAPLRFSDHKPVWGLFSCEVCVVDQAKKERISNELYAKRRAVVGNHTAGDMADSDDESLYGYTSVEAGLPPASSNDRKWWLDNGLPAQSTVKPPSASHIPNPARLSNPFTPSNELDWVKVDIPGNTPPLHPASLSRSPSRGGVRGEIVPRKSAPSFKAPQQNAQHPTNLAGTQMDGHGDHQLRQTLRKPAPPPKPTKPNLLRSSSGTSSVSSSVKSVHPPPLPESRRAHNAPHQSMTRNVILPPPPTRANGDTEKRIPAPLPPPPRKPVKTNFQNGGKMSAEKDDEKAPALPVRRPTAPLMDEDGNGEAELGGWIPLRPTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M3BUJ4</accession>
    <name>M3BUJ4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_150048</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759125.1">
        <property type="nucleotide sequence ID" value="XM_016905934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BUJ4"/>
    <dbReference type="STRING" id="692275.M3BUJ4"/>
    <dbReference type="GeneID" id="27903071"/>
    <dbReference type="eggNOG" id="KOG1176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_2_1"/>
    <dbReference type="OMA" id="AWPNTDF"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF194">
        <property type="entry name" value="AMP-DEPENDENT SYNTHETASE_LIGASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="36"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="2">
        <location>
            <begin position="452"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF11004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="556" mass="62491" checksum="14D11BA75EFE1D55" modified="2013-05-01" version="1">MIHTSPFPDLNIPKVNVLSYLFPQDQVPSDEPVWYDAANPRKNVSPRQMLSWIKRVIIGLDRLGLKKGEVCLIHTPNHTLVPAAYLGIVGGGRCFSAINPIYTVDEIVHQMKLTDAKVILAHPLLVKNAVAAAKKAGTNPKIYQFTDDEAPLQEMDGVKDWRAMLGTAAEAETYRWKELTAEESVRTVATINFSSGTTGLPKGVMIGHHSLIANVEQTMATTWPQHNFTKGDKVKERWIGFLPLYHAYGQMFAIMMACKLHVPIYIMRQFIYEDFLRVIQDYKITHVQVAPPVLVMMAKRPETSQYDLRSIQELLCGGAPLGKDLQNEISRKFHCSVKQGWGMTEVTCGSIRQLESSDNGTVGKLVPNTHLRLVDENDRDVGWDSPGEMLIRAPNVMLGYWRNESATRDALTPDGWLRTGDVAVINKEGYIWIVDRKKELIKVNALQVAPAELEGILLDCEYVADVAVVGITIHDEEWPRAYVVLTEGARQKKISPADIQMWLRPRVAKHKALVGGVKFVNEIPKLMSGKIQRKVMKEWSKRDAPEVAKGFVRSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M3BVQ0</accession>
    <name>M3BVQ0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein sip5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_150339</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIP5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759520.1">
        <property type="nucleotide sequence ID" value="XM_016906105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BVQ0"/>
    <dbReference type="STRING" id="692275.M3BVQ0"/>
    <dbReference type="GeneID" id="27903242"/>
    <dbReference type="eggNOG" id="KOG2789">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009068_1_0_1"/>
    <dbReference type="OrthoDB" id="21471at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24139">
        <property type="entry name" value="SIP5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039301">
        <property type="entry name" value="Sip5/DA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31315">
        <property type="entry name" value="PROTEIN SIP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31315:SF1">
        <property type="entry name" value="PROTEIN SIP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="451"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="528"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="595"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="732"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="57"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="177"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="245"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="317"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="451"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="469"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="542"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="616"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="666"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="732"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF11399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="839" mass="90589" checksum="518FAC325FADEE09" modified="2013-05-01" version="1">MGNSSSKDERRSARPNQATTQAQSAPQQPSGERRVYIRASGVASARGSSQNLFLRLGRSERDGDGETAQPERPRETKQEREARRAERERQARLKERERSMREEHVDGGYLVTVGVYVGPEDFNKQIVRQLQIERKLAPFWRGLNDHSDAWTEAQLVAAAKGLPIPAADEVPPEMGRTASQASSSPRSDVNVNSLTVPITSRSQSYQSDVSASLSASHPAFSSRPSSPTNAGSSMFRGRAKTLASLASGTKNQSSDLTPQEVRLPNDPNVNGQPLEAYLYKDAIECPICFMYYPPYLNRTRCCDQDICSECFVQIKRPDPHPPEHEQPGQERPSGEEAEQLVSEEAACPFCVTPHFGVTYEPPSFRRGLAYAHQNAGLRPQAPAMASSTSLQAPTGRRRATSLSANAPGVVTTDTVRPDWAKKLSDARANALRRSAAATALHNAAYMLGGQGDSTGRAGFGLGRRRRTLFGDSPGASGSGSPHEGEGNDIAGGRTSSRRTRAEDLEDLMMMEAIRLSLAAEEERKQREEKLAAKDAKKKAKLDKKEEKKAEKMAKKTGRSGSLYQLGTNESASSWAGTSGMVRSTSNLGAQPTIPEEQVQGKGKQPAHDFAGFNPLTEPTSTLNRRPSSPSTAESAQQHLEAQRARFESHSSPIPAPAKHGQHLRDTSATSGVSSVASSYSGQNSGFSSHNATGVDVSAGQLESTSTRSGTNAVAGGEPMLNFRSLTAMIESDDKSNSQHLEHVEPSSQAAEQLKEPSPTGSPRIPPTYLSGDGNRSRGDSGESSSSAPPPVYVEQHSEVKHDNDVITPAPQHFAVHHPDHKEACKVEFVDHGHERVGET</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M3BWX2</accession>
    <name>M3BWX2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_149185</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760667.1">
        <property type="nucleotide sequence ID" value="XM_016905396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BWX2"/>
    <dbReference type="GeneID" id="27902533"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006937_6_1_1"/>
    <dbReference type="OMA" id="HGFPYTY"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF6">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G15050)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF12546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="613" mass="69039" checksum="828E4E7C990769FE" modified="2013-05-01" version="1">MGSIEAAIPASGDIFHLKRNTSTTVESIDDGQQTPPLARPKDEWVYPWPTNFKISEHPIDEVRRLKVAVIGAGLAGITAGALLPAKVPGIDLTILEKNADAGGVWFENRYPGVRCDIPAHVYQSTFTPNTHWTEEYAQGNEILAYWQSLARKHNVYEHIRFRTKVVGMYWDPTRSQWRIETVHVEDGHSSSEHYDYVVTAIGHFNEWKLPNYPGIKDFKGPLFHSSNYDPKFDPKGKRIATIGNGASGIQVTTELQKVADHVDHYARNRTWIAGSFNPAVRDRQDKPMYFDSETVRSFKDPVNYLKYRKELEGNFFRGFESQLVDSETTKNLRQTFIEAMRTRTSEKPEVLDKLIPDFPPNCRRLTPGPGYLEALCAPNLDLIQTPIARFVEDGIITVDGIKRSVDAVICSTGANVDYAPPFPIVSGDLDLSRDWRPDGKLGWPRSYLGMATDGFPNLSYLLGPNPAGPSGTVPHAVEIQVTYVAKVLRKISTQGIRTIVPSKAATDDFIAYADAFFPRTNMALKCSSWSNGGRPGARIHGHWPGSGAHVTYARRDPRWEDYEYSYVVPGNRFAYFGNGQTAAEKDAERDMTPYLKLAEDNDLRDLHERWWDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M3C057</accession>
    <name>M3C057_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_148919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761827.1">
        <property type="nucleotide sequence ID" value="XM_016905227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C057"/>
    <dbReference type="GeneID" id="27902364"/>
    <dbReference type="eggNOG" id="ENOG502S94T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053358_0_0_1"/>
    <dbReference type="OMA" id="QPRFKHA"/>
    <dbReference type="OrthoDB" id="5402392at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF13706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="458" mass="50358" checksum="C676A501F50F6408" modified="2013-05-01" version="1">MTDVLEGCPLPKEVAEALQPYIKTRQEVEHVRRGLQASFPVSTLDTARKSYSETPEPGGLTGVRKAYLQALQAHRVAQERYDALKTELEQLSRREPTPGGAQGNTTAFLTESYVPLIRQRERRRKLAIVEKTLAKITAAGGDAVVESFDKVAKREVGELPHPPSTSGYADRELESDYDLTRLKKAILSTKRELEEHEELSAQANGIAEGDINPHADLKALQKTHSELTAWMENQLAMISDVDSTKDGSSSTYSAADNSAGEEAAFSLSDIENLYKQYLDSRQRLLRVVSHQERQDSSPSSSPDTARRRSTSPTTPTTTTTTTLDSDPSLPAPSELILPYLSRLTSTKQTSQSLSQQTTHLRRQLTLAETQTQDILTRLADESHLVQPEHHHHRRRGGGGAPQGQDWREAAEEAREATVNIVKKRVESGNAFAEQAVQTLESIHGLPGCVDGISLAGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M3C0F6</accession>
    <name>M3C0F6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Translocation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_148984</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761932.1">
        <property type="nucleotide sequence ID" value="XM_016905267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C0F6"/>
    <dbReference type="STRING" id="692275.M3C0F6"/>
    <dbReference type="GeneID" id="27902404"/>
    <dbReference type="eggNOG" id="KOG4699">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066294_0_0_1"/>
    <dbReference type="OMA" id="KPWFPAH"/>
    <dbReference type="OrthoDB" id="73168at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031207">
        <property type="term" value="C:Sec62/Sec63 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018624">
        <property type="entry name" value="Sec66"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28229">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28229:SF1">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09802">
        <property type="entry name" value="Sec66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF13811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="274" mass="30746" checksum="F09C426670E5E474" modified="2013-05-01" version="1">MADTNSTFNSSTNGTFNGTFNGTNSDFTPPTPPNFWLGLLWPILYITILVGSLSTFSSLYRKRQISKAARLESWFPPHRQRDIYLSLLHLDPSEDAGEDEKKLKSVPDNVLKAALLQRAVEDIQRIVQLRSSKPALQTLLQRGSVGDELWQRFLRAEREMEEEVKDVVNEANAFAPNWGQIIFQSANEMNQNRILKERIAELQATTQAEKDWWEKRRTGIKANFLKELDEDEAATAKTQIPQGSSDEDAPVLVEAGGPQGAQGSMKGKKKGGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M3C360</accession>
    <name>M3C360_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">D-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="6">1.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_148349</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(R)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13521"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.4" evidence="6"/>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762837.1">
        <property type="nucleotide sequence ID" value="XM_016904863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C360"/>
    <dbReference type="STRING" id="692275.M3C360"/>
    <dbReference type="GeneID" id="27902000"/>
    <dbReference type="eggNOG" id="KOG1231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017779_3_1_1"/>
    <dbReference type="OMA" id="GQGFEWA"/>
    <dbReference type="OrthoDB" id="7786253at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903457">
        <property type="term" value="P:lactate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000014">
        <property type="entry name" value="D-lactate dehydrogenase (Cytochrome), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748:SF116">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE (CYTOCHROME) (AFU_ORTHOLOGUE AFUA_7G02560)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="10">
        <location>
            <begin position="175"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="20"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF14716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="608" mass="66447" checksum="4B698C25ED041DAD" modified="2013-05-01" version="1">MSAPTRLVQRRLCSARIHGACRGSSRSGAQQHQRGRRAYATEEKDPNGRESFKGQLYQSTHERVVREKQDQARFAAQREQEKAANSSGIWFIPIVLAVGALGGWLMGKQSPAKPAPNSTLPLALATPPNHDVSPATLQAAWSDFKDIVGEENISTEQSDLKSHAGSEWSTHHALDDDVPFAIVRPASTEEVSAIMKVCHKRRIPVTGYSGGTSLEGHFAATRGGICVDFSRMDKILVLHKEDLDVVVQPAVGWETLNEELGEQGLFFPPDPGPGAMIGGMVGTGCSGTNAYRYGTMKDWVLSLTVVMADGTIIKTKQRPRKSSAGYDLTRMFIGSEGTLGLVTEAVLKVTPKPQSTNVAVCTFPSIRSAADCVFRVVGAGVPIAAIEILDDVQMRCINQAGQTSRPWKEVPTLFFKFAGTPTSVKEHISIVKDLAKKSGSKTFEFAKSPEEQAELWSARKEALWSVMAQKKNNGDHVWTTDVAVPISRLPQIIEETKDDISKSGLIGSIVGHVGDGNFHAIILYNDKEHEIADRVVHKMVKRAIEMEGTATGEHGVGLVKRDYLNHEIGEPAVDLMRKMKQSFDPLCLLNCDKIVRIQQPKPGEVAEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M3C4N3</accession>
    <name>M3C4N3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_37829</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763382.1">
        <property type="nucleotide sequence ID" value="XM_016908681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C4N3"/>
    <dbReference type="STRING" id="692275.M3C4N3"/>
    <dbReference type="GeneID" id="27905818"/>
    <dbReference type="eggNOG" id="ENOG502S522">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109915_3_1_1"/>
    <dbReference type="OMA" id="ITTIFWF"/>
    <dbReference type="OrthoDB" id="2117453at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451">
        <property type="entry name" value="MARVEL DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451:SF1">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="6">
        <location>
            <begin position="11"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF15261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="130" mass="14134" checksum="19AE02E9A9614BAD" modified="2013-05-01" version="1">MALYDNPAVVLALRLIQATFAIIVLGTSAFVAHWWNSYYNGIAHSPSSINFLIFCAVWSLLALVYLILVPMLFANTVLHHKFAILGLEAVTMLFWFAGFIALAVFLPGRGCTGTVCGSARAACVFGAFSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M3C5P7</accession>
    <name>M3C5P7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transglutaminase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_11981</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763717.1">
        <property type="nucleotide sequence ID" value="XM_016901545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C5P7"/>
    <dbReference type="STRING" id="692275.M3C5P7"/>
    <dbReference type="GeneID" id="27898682"/>
    <dbReference type="eggNOG" id="KOG4575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016738_0_0_1"/>
    <dbReference type="OMA" id="HGKGFGH"/>
    <dbReference type="OrthoDB" id="6129702at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.620.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052557">
        <property type="entry name" value="CAP/Cytokinesis_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46333">
        <property type="entry name" value="CYTOKINESIS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46333:SF5">
        <property type="entry name" value="TRANSGLUTAMINASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transglutaminase-like" evidence="2">
        <location>
            <begin position="323"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF15596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="595" mass="64441" checksum="73397178932FE33C" modified="2013-05-01" version="1" fragment="single">RPPLPSRTSSTQSSQAPGPLPRAPSGPSPALPPRRPSETPSQPGYAQNRRGSTESTSSVTTSRSAGGELFKIRASEFDPSSLPALPPKRTAEEREAADKKYNGPRPLRHTKSTPRVAQVQQGTTPPAVPVRQTVIQPPLPVGNNRQVVPQRSESTSLSVRAEALPAPKARTSALSWGFNNETSNSAPASASRNDAVAPASGVPPPIPASTKPNLAALLATKPKPNSGFDLSARVAALDPSPTAPTNSCLHCRDFTGPDSHAARFPRQSIPSHDVGWLAQQLTAPFTSLTDKARSIFTWLHHNIAYNTQAFFSNNVQGSTPQSTIQSGLAVCEGYAGLFTALAVKAGMESFVISGASKGFGYRPLTPGQPIPPYQSDHAWNVVKIDGGEWKLIDSCWGAGNVKETQEYEKSFKPDWFQMSNNIFGLSHYPERRDQQYREDGTALSWEEYSMAHKDGTGATMFDSGTEEGISKTSMRPSESKIDLSQQGPTVRFSFQKICPHWDPIRNGKGPPYLFVLLIDAQEKNSDRNLPPLQTNGSVWWADVPREHLGRSGQKIMLIALTSFGGRDGRGLTLQEYQRGKGRCGWASSGIATWEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M3C798</accession>
    <name>M3C798_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endoplasmic reticulum lectin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Protein OS-9 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_147787</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Peripheral membrane protein</topology>
            <orientation evidence="1 7">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the OS-9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF16136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764257.1">
        <property type="nucleotide sequence ID" value="XM_016904525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C798"/>
    <dbReference type="STRING" id="692275.M3C798"/>
    <dbReference type="GeneID" id="27901662"/>
    <dbReference type="eggNOG" id="KOG3394">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025069_0_0_1"/>
    <dbReference type="OMA" id="AYPQFEV"/>
    <dbReference type="OrthoDB" id="448954at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045149">
        <property type="entry name" value="OS-9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012913">
        <property type="entry name" value="OS9-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15414:SF0">
        <property type="entry name" value="ENDOPLASMIC RETICULUM LECTIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15414">
        <property type="entry name" value="OS-9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07915">
        <property type="entry name" value="PRKCSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 7" id="KW-0430">Lectin</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004031670" description="Endoplasmic reticulum lectin" evidence="9">
        <location>
            <begin position="21"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="10">
        <location>
            <begin position="162"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="489"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="490"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="539"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="566"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="583"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU369099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF16136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="600" mass="65889" checksum="7B94AD89F0F222F9" modified="2013-05-01" version="1">MKHFLALPALLRGSVLLALASQHSFSVQDDIFAFPQYEVRFADEWIPADQVPARLASNAKGSTSRTSERSEEQARTYTQVGQYRQQQPLVGGGHDTTIAHDDTEYEHERMVLDGQPWLCRIPKVKTAATAGSANETVSQAEQDKELTRALDRGWELLSGMEGNCVFFISGWWSYRFCYNQGIKQFHQLSPSRGVPVYPPVEDAGVPGFMLGTYAKRLDADDTGHTRDWDGESALEKSEGAKRFHSKHGELVQRGESRYLVQKLGGGTVCDLTGKERKIEVQFHCSPQAVDRIALIKETSTCAYLMVIQTPRLCNDVAFLPPQKDHPNSIACSPILRDEQVAAYEQDIEALKAEEREVKEWLANSENRVATAAAMAGIPEAIVAGITGAVSEGAVLPVGDVFVGGHRLVPEGVKIEKSAIVGGGKETYIDTLADSEGKIISKEELERLGVSDPKAVEKLKKEMEQLAQGQAWKLDVIDTPRGREYRGIIGEGEEEGAMEQDSTQEDSSGTAKGDGVKAQQGEKKQGGKTVGAQHGNKKLAGTQQGNQGQAGKATGSQQDTKKKQKKKTEEEEKKASHVRKQDDDEKDDQLGSEEEFYKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M3C9L0</accession>
    <name>M3C9L0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_128849</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756636.1">
        <property type="nucleotide sequence ID" value="XM_016902236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C9L0"/>
    <dbReference type="GeneID" id="27899373"/>
    <dbReference type="HOGENOM" id="CLU_1422234_0_0_1"/>
    <dbReference type="OrthoDB" id="17098at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF08515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="191" mass="21279" checksum="9333801FAA96E681" modified="2013-05-01" version="1">MEGKAHYKQTQPGEGLVPGKLVLTVLVVRSASVFVIATPPDQTKPDTIDNFWLPSTVLSDVTMADLYREALSLAEAWTGLRDKDMFVDRRSVLYDNLPYPLTAPGGERSGPLFKTAFVRVKLVTKASRNQTLSVEPDQALLEAALEDEEVQFGGSWLSREDARLALDQDMEALRPVRRLFGLEKEDNNNES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M3CFW7</accession>
    <name>M3CFW7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_45291</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760824.1">
        <property type="nucleotide sequence ID" value="XM_016908962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CFW7"/>
    <dbReference type="STRING" id="692275.M3CFW7"/>
    <dbReference type="GeneID" id="27906099"/>
    <dbReference type="eggNOG" id="ENOG502SPGU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079928_0_0_1"/>
    <dbReference type="OMA" id="PENAAGW"/>
    <dbReference type="OrthoDB" id="2367685at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="30"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF12703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="236" mass="26075" checksum="4CECCB2FEF536E31" modified="2013-05-01" version="1">MASNEYYGGGGGGGGGGYEGGYDSRPPPPRDLPYPWRAEWEPQQNRYIFVNPQNGERTFEYPRIGGQGQAHGASYDGGYGGSSSTQEQVHEEKKKSGGHGWMGAALGAAAGLAGGAFLMHEGHEMKEKIEGTEERFEEDKYRAEDRDVEDAPEDVARWAGRKVQDVEDIPQDIEGGFDRFGERVENRWDNAVDAVEDAPEDAARWAGDKVGEVEEFGDRMDNAYDQGQDESRNDDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M3CG64</accession>
    <name>M3CG64_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_149348</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760914.1">
        <property type="nucleotide sequence ID" value="XM_016905503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CG64"/>
    <dbReference type="STRING" id="692275.M3CG64"/>
    <dbReference type="GeneID" id="27902640"/>
    <dbReference type="eggNOG" id="ENOG502SJ9Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024460_0_0_1"/>
    <dbReference type="OMA" id="KWREADT"/>
    <dbReference type="OrthoDB" id="3029470at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF12793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="486" mass="55012" checksum="7838F8E2282774B2" modified="2013-05-01" version="1">MAGSTAALFSGIAKDRVSASNPASSGTDIDADRCAALHNTLTLYGWVCSGKKISTLTKRTWWSTHGNERLKQILRPKLVRYLSKIFEVPNYNFFYHVSGLATPAHMLGLADVLEDPDHDHDDPKEDKYRFVIIYKSSEALVTQPAGIVFDQKTGKALLMPTYHHVFDLRNPELPWQRMEAILSAYIEMIEAEKAVAIHDEATIEEPKTDITGGDLVQNKTFVRYKTRPWILQPYTLEDLHACIDTWDALVSAIEKNAGISKARPDPEGEDYDPEDEAPLCSRTALKIAGIPRGFAYEILSHARQSDIWFIAPGIRLPKVEEFLQQPFKHIPQQFPKETAGMKVPFLFLRCPGTVSAKEAKFRYPFSTVESVPCGLYLDAFPNAQNPFEDACRLVLPIKLGDRRHYARTSDGRPILKSHSELYQTGINPFVMRHGPKLSAVLQNWRSHVESGHWSVNERGVEGGVGVWRQADTRENWWRYQSEHLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>M3CI99</accession>
    <name>M3CI99_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_64558</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-14 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761664.1">
        <property type="nucleotide sequence ID" value="XM_016909683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CI99"/>
    <dbReference type="STRING" id="692275.M3CI99"/>
    <dbReference type="GeneID" id="27906820"/>
    <dbReference type="eggNOG" id="KOG0239">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001485_12_1_1"/>
    <dbReference type="OMA" id="MCRVRPP"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031852">
        <property type="entry name" value="Vik1/Cik1_MT-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KLP-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972:SF45">
        <property type="entry name" value="PROTEIN CLARET SEGREGATIONAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16796">
        <property type="entry name" value="Microtub_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 6 7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="10">
        <location>
            <begin position="469"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="203"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="144"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="561"/>
            <end position="568"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF13543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="875" mass="96659" checksum="E64D3E0C097CCFF3" modified="2013-05-01" version="1">MDTLENTRPSGLKPPSRLPAFNNLHRALQETTSSDQNARTAHGAGNDRHGGAMGPPSSIIPSKHKVSGLPEPPLKRKTLAERAGEPSGTLRTKPSVANGFGARPATSDSNLSRTASGIASATGSLRGARPSSRQANPFGLVPRTNSSYSVSKTTTSSHYDDEDDGEVALSGSRKAWDTNGRLDDMERMYIQLKGDIDVANTAKDSIESTLAIYKARTAELEKEKNELKTDLRASSVDLERTRNELHTTSTDLRQIRRDHEREMLDMERRLEKESSELRLKQEKQEFQFEREREKLADRFRREMEEARRTWERQQNDKEADLTSQSWEEMAQLRAEHEKEKAIMQKELEELRQAGESRATESASEVQSLRDRSADLQRQLEASKATEITLRSRITAFEARITALEQERNTLVSKAHFLEGNQEAQSLEFTNMRKSLEEAVAAKDVAVETLRKEEVLRRKLSNTILELRGNIRVYARTRPLLKGEDDPTKVDYLDEDSLEGCKEMVVHTSTTSAAGEVRKEVHNYAFDRVFTPGTPNLTVFQECQDLIQSVVDGYNVSILSYGQTGSGKTYGMSGPDGIIPSAIHMLMAEMQRLKTKGWEYAVDANFVEVYNETLNDLLGDAKSWDDADDLGASVRGKVKEKHEIHHDAVTGKTSVTNLTTNRLWPPPADHGNWPPAAPIEGDVVDVATSANAYTEQAVANLLDTAAKNRRVAATKANERSSRSHSIFIMTLRGTCAATGESSEGVLNLVDLAGSERLKQSEAKGNALKETQAINKSLASLGDVIAALGSKSGGKAHVPYRNSKRIMLLDPGSWLTFVLQLTYLLQSSLGGSTAGKSSRTLLLLHLSPLQAHWQDSKTSLGFGTKVVGTHIGTAKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M3CLG2</accession>
    <name>M3CLG2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_106927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762754.1">
        <property type="nucleotide sequence ID" value="XM_016900658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CLG2"/>
    <dbReference type="GeneID" id="27897795"/>
    <dbReference type="eggNOG" id="ENOG502SX98">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093941_0_0_1"/>
    <dbReference type="OMA" id="RAVHQDY"/>
    <dbReference type="OrthoDB" id="5367448at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF14633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="30327" checksum="0DC8B06E254A2BD9" modified="2013-05-01" version="1">MASLARPLTNRAVHLRITPRPSNLGESREILRLISAFGEVEYFKNLKYDALSAPTTALVIFKHEEAAMQCMKRSPIRFRMGKAAVGEEIAGPAPSPSPSPAPTTAPPVPASEASAVPAQHIPSRSGGAWGLGGQTRAMSTTSSYAPMDTLPNPPARPVRTPFQAPPLPLLESRIFQVQTNPAHAHFRDQINMGYYHGRFAIDSKSVPQTDLAQTVPLPGLSCVNWKAKERPWRLMNQEKERDRTGPHRRKSLRELYDTHHETAGTADFRNEALSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2022-12-14" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>M3CWR0</accession>
    <name>M3CWR0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_152393</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF08111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756232.1">
        <property type="nucleotide sequence ID" value="XM_016907419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CWR0"/>
    <dbReference type="GeneID" id="27904556"/>
    <dbReference type="HOGENOM" id="CLU_1876721_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF08111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="136" mass="15631" checksum="E93E725192AD8E13" modified="2013-05-01" version="1">MPCSLLDPSGKLIELTRRYLINPHTNPSNQHSYTYSAAGRGQILLRPHRRSRTSASRVPRSPPHACRLQRDDPLSHGEPLLALGHLQLRLRHGTICQTRASCIWQLVLRFLRMIDCIWSISYNPEWRTESELGTLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M3CWW0</accession>
    <name>M3CWW0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_121381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756728.1">
        <property type="nucleotide sequence ID" value="XM_016901684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CWW0"/>
    <dbReference type="GeneID" id="27898821"/>
    <dbReference type="HOGENOM" id="CLU_1644764_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF08607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="161" mass="17794" checksum="7E2C7E6E1ACF49F8" modified="2013-05-01" version="1">MASKIDDSFNAPEDSGVPQCQCPTPLQAAGGIPTTTPPYPPPPLPPRIGNSKAAATSSSFPEDVHSQDQTRPTLGKNAPSASLGRLKKAKALFRNIKKDKSDRPRTPGRNPGAIHWISTGDYGMKHRFFQRQFDESDARKKAQYNDCKMSFQLRHKMSSWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M3CX67</accession>
    <name>M3CX67_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_166745</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756387.1">
        <property type="nucleotide sequence ID" value="XM_016908254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CX67"/>
    <dbReference type="STRING" id="692275.M3CX67"/>
    <dbReference type="GeneID" id="27905391"/>
    <dbReference type="eggNOG" id="KOG2495">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021377_1_2_1"/>
    <dbReference type="OMA" id="WHLIDIA"/>
    <dbReference type="OrthoDB" id="3244603at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706:SF17">
        <property type="entry name" value="NADH DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="6">
        <location>
            <begin position="6"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF08266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="429" mass="47970" checksum="BCDE4B25CD8177A8" modified="2013-05-01" version="1">MAAKQTVVIIGNGWGGFTVAHGLLTSKYNIAVIAPIRTIQYTPLLASAAAAHFDFRLAEEPVRRRNRMPELRYHKANVEDIDFDKRLVYCRPAIANIAGNDFSNKDKSCFTVNYDKLVIAPGCINQTFGTPGALEHANFLRTTNDARLIQQRILEMLDAASVPGLTDAQQRDILRIIIVGGGPIGIEAAAELFDLWNDDMKYLYAHLQGKFSIEIHDVAEKLLGSFEGKLGEYAEDKLKKRGIEIQTESHIEKVEADAIYTKELGQIRYGLLLWATGNGANPLVEKLESVKKTDKLPRILTDKRLRVLQKENDQVMENVFALGDSADIDGNFLPMLAEVAVQKAEWLTKALNDDGGESPKPFEYKQKASLAYLGGQDGVADGEWTGQSAWLAWRSGSIWHWPRSWRRTLMIGISWIFNVVGGRDIARKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M3CZ67</accession>
    <name>M3CZ67_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SGT1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_52645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757072.1">
        <property type="nucleotide sequence ID" value="XM_016909236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CZ67"/>
    <dbReference type="STRING" id="692275.M3CZ67"/>
    <dbReference type="GeneID" id="27906373"/>
    <dbReference type="eggNOG" id="KOG2406">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006241_2_0_1"/>
    <dbReference type="OMA" id="TKDYIWQ"/>
    <dbReference type="OrthoDB" id="27237at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010770">
        <property type="entry name" value="Ecd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13060:SF0">
        <property type="entry name" value="PROTEIN ECDYSONELESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13060">
        <property type="entry name" value="SGT1 PROTEIN HSGT1 SUPPRESSOR OF GCR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07093">
        <property type="entry name" value="SGT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="552"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF08951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="620" mass="70055" checksum="669C7548585725D0" modified="2013-05-01" version="1">MEDQLPDDGLKWFGEGFDGFPKRLPDDCVEYVIHVVHGGLNSTAALRTRLNEILKAANEFKKTLLKDYIWQRQEFDLALHPKIDLSKPDQNEAVKTVPHLRGRTDFGDSVADEWLVVHLLHELSKKFPDAWIRVYDTDGEFLLIEAANSLPKWLNPEIAENRVWIHEGRIKIIPLDEHSPPRNLTSEEALLFIKRTPDKLLVDPSIEKEAFHRLQEYPSAISSSFHHALVTIPRRLAYLLHRNPSYISPAIEAFYLRDPISLKPLATKDTNTLNFPPEDFVTVSVKFTKVGYAQLRSQLFDPPPAWTGIIPRMQDEKVAIGMKLTCGFEMVVTDSQNQDKRAVREMKLLLEDMENGEEDLPTDSELKEWPKTQDDEKWLDIDYNDFEKELDGKGEARGKKGGFGDQGAQDNLRKMVSRFEDFLEDDEAGVDGVDDMDDDDDGDATSSSSVNDDADTKTNDESEEPPTCFNGPEALEDMEFERAIHDTTAMPDWHLEKSGLLDEARKLALEDDDADMSDIDEDEEMRKVIELMEQELKGHGALNLENGTYKKVRSTDNAAKSKPEGAELSSDEEEFNDVDLDLAKNMLEAFKGQAGMSGPAGNLMKALGVSMPRDEGGDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M3CZ73</accession>
    <name>M3CZ73_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SPIN90/Ldb17 leucine-rich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_151845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757077.1">
        <property type="nucleotide sequence ID" value="XM_016907076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CZ73"/>
    <dbReference type="STRING" id="692275.M3CZ73"/>
    <dbReference type="GeneID" id="27904213"/>
    <dbReference type="eggNOG" id="KOG4035">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017272_0_1_1"/>
    <dbReference type="OMA" id="ERMCEII"/>
    <dbReference type="OrthoDB" id="445362at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000147">
        <property type="term" value="P:actin cortical patch assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030125">
        <property type="entry name" value="SPIN90/Ldb17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018556">
        <property type="entry name" value="SPIN90/Ldb17_LRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13357:SF1">
        <property type="entry name" value="NCK-INTERACTING PROTEIN WITH SH3 DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13357">
        <property type="entry name" value="SH3 ADAPTER PROTEIN SPIN90 NCK INTERACTING PROTEIN WITH SH3 DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09431">
        <property type="entry name" value="SPIN90_LRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPIN90/Ldb17 leucine-rich" evidence="2">
        <location>
            <begin position="214"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF08956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="587" mass="65434" checksum="51026F9B1847FE96" modified="2013-05-01" version="1">MSDQSSPELAVESEAQFWTELDDIISPDLTTSTASLATSDVTAESPTGSLSSSIFEDHGHIDDALRRYLAFASRHLRDYLPSEYDVARCCWKLLDAELFKRNGAYVRRQILYCLLQEEDTSTLHLAAAVLLFDGRANESTFELMQAEGTFQRLLDLIREKRDDDDVGLHRLLLELLFEMSRIQKLSRDDLTAVDDAFILHLFQLIEELSSDANDPYHYPIIRVLLALNEQYMCQANAPKSPGSADIGVTNRILKLLSFHGPSYRTFGENLILLLNRETELGPQLLILKLLYLLFTTPSTYEYFYTNDLNVLVDVIIRNLLDLDESHDSDLAPDRDGQRALRHTYLRVLCPLLKNSQLAHEGQNYKRLEVRRLLYLLIDRTSAHFAPVDETVIRLVIRIKQIDWIREEGDEMEAAIEEKLAAVSVAYGVTAQNGSSSGNSGDEVVAKKLLGMSLSEAGESSLSVSVSDVTAKVVKAKPSVPIPRRMRKTSKVAANGGPGGSPATTQAAVVKDGLEERLLEVSHAPRDTTQAVMIEPETQRRPKLPPAPPKSKYGRKVIADTLKPNAASVQIPMRNDSRSPFADENAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M3CZ95</accession>
    <name>M3CZ95_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Aquaporin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_159061</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757102.1">
        <property type="nucleotide sequence ID" value="XM_016907821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CZ95"/>
    <dbReference type="STRING" id="692275.M3CZ95"/>
    <dbReference type="GeneID" id="27904958"/>
    <dbReference type="eggNOG" id="KOG0224">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020019_2_2_1"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015254">
        <property type="term" value="F:glycerol channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050363">
        <property type="entry name" value="MIP/Aquaporin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00861">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829">
        <property type="entry name" value="AQUAPORIN OR AQUAGLYCEROPORIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829:SF24">
        <property type="entry name" value="MIP AQUAPORIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="424"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="454"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="506"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="118"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="187"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="221"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF08981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="584" mass="64263" checksum="0E08723C5D1A74D4" modified="2013-05-01" version="1">MSIQVPIGDVSGQICCLLRSWSCSCVQPRRYRNPKKGKYRYFQLRRVKIAIRPHSAGIVGKRSLRRGPTSPDSVASSLRTTFSDVAHEDSIFHRHAAYNNLQTAMSSRSLRPYQARTATARSTRTAATGISQDVDYTLAGPPSQAGHADPHGTHYDEGYFDANPWMETQQPQNENFSLAGTFPHKIRWGSKKPKHGSYQHNVSSDEKGEAEAAPQIKEHPSDDDDEGDEGENIEPSTTRQSLRPSIQQRTVSHYNSKGQRRGTLANEAIVEGLDPKDRPFNHWALVRLRLQRPLAEWLGSTVFIFIGVSANLSVITSNYQTGTMQSMYWCWGFAVMLSIYIAGGGSGAFLNPALTLMLSVFRGFPARRVPVYIAVQLLGAFTGALLAFAIYKDDIIHLDGGLIPESTGMAFYTQPKDWVSNSTAFFTEMLGTAVIGCSIMALGDSHNSPPGAGMHAFIIGLLTTAVTMSLGYSTGGCFNPIRDLGPRLATIAVGYPASAFTAKQNWWIWGPWCATITGALLGGLVYDLCIFKGGESPVNYSYGRWRIETLKNEAGIAHALGLHERKDEIERRLESGEIHDEPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M3D000</accession>
    <name>M3D000_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein uS13m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_151210</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758335.1">
        <property type="nucleotide sequence ID" value="XM_016906674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D000"/>
    <dbReference type="STRING" id="692275.M3D000"/>
    <dbReference type="GeneID" id="27903811"/>
    <dbReference type="eggNOG" id="KOG3311">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103849_2_4_1"/>
    <dbReference type="OMA" id="MNVKRLM"/>
    <dbReference type="OrthoDB" id="525520at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.910.10:FF:000004">
        <property type="entry name" value="Small subunit ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="entry name" value="30s ribosomal protein s13, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="Rbsml_uS13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_uS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_uS13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S13/40S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US13M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8 9" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF10214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="119" mass="13720" checksum="1C585448CAB8A9F3" modified="2013-05-01" version="1">MVGLFGNNFAESFLVRNSLQSFYGIGPKVCQTLMARFHIHNTARIGSLKERQINALAEELSKMVLENDLKRQLHDNIKRLRDMGSYRGRRHAMGLPVRGQRTRSQIITAKKLNRVERRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M3D3R6</accession>
    <name>M3D3R6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitrilotriacetate monooxygenase component A/pristinamycin IIA synthase subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_45207</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760665.1">
        <property type="nucleotide sequence ID" value="XM_016908956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D3R6"/>
    <dbReference type="STRING" id="692275.M3D3R6"/>
    <dbReference type="GeneID" id="27906093"/>
    <dbReference type="eggNOG" id="ENOG502SJM8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022256_0_0_1"/>
    <dbReference type="OMA" id="FNIAYHV"/>
    <dbReference type="OrthoDB" id="5561043at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="entry name" value="Luciferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051260">
        <property type="entry name" value="Diverse_substr_monoxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011:SF41">
        <property type="entry name" value="XENOBIOTIC COMPOUND MONOOXYGENASE, DSZA FAMILY (AFU_ORTHOLOGUE AFUA_3G15040)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="Bacterial luciferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase-like" evidence="2">
        <location>
            <begin position="19"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF12544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="457" mass="50767" checksum="DCFAA18E0511E045" modified="2013-05-01" version="1">MNAFAMTAPGHLAPGLWRHPNQEPQTLDHWVRLAKMLDEAGFHGIFFADVLGIYDVYQSSNGPALKAAAQVPELDVSLLVSAMAYATKNISFGITASTSYEHPYQLARRYATLDHVTQGRVGWNIVTSYLESAAKSYGLDQLTQHDDRYEVADEFLEVVYKLLEGSWEDDAVEANKTTGIYTNPDRVHPIHHAGKHFRCRGPSIVHPSPQRTPFLLQAGASKAGKNFAAQHAEAMFLPGMLPEKTRQIVDSTKALLIEKGRQPSSIKFIAGIFIVVDSTDEKAQTKFHKLLQYADLEGTAALFGGWTGTDLSQFSDHDENFSFKNGPPAIQSLIDSWTKTVPGLENVKWTKQHVLQQLAISGAHPRAVGSPQTVADIMEEWIEKADVDGFNISYAVTPDTFEDIIRYLWPELRKRGVLQEGYVGETMRENYLGDGLGPRVREGHPARKYWGAFVGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M3D4J2</accession>
    <name>M3D4J2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoglycerate mutase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_149353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760920.1">
        <property type="nucleotide sequence ID" value="XM_016905505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D4J2"/>
    <dbReference type="GeneID" id="27902642"/>
    <dbReference type="eggNOG" id="KOG4754">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039184_1_0_1"/>
    <dbReference type="OMA" id="MRHGQGY"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF54">
        <property type="entry name" value="PHOSPHATASE SPAC5H10.03-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF12799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="251" mass="28150" checksum="2F57021CB332AE33" modified="2013-05-01" version="1">MSPILHVMRHGQGYHSSAVTKDGHLLRDPFLTEKGKQQCRDRCKAFTRHGHIELLVASPMRRAIQTCQLSFQPAVERGLVIVCLPHAEEVSDAPADTGSPVNVLQAEFGSAVNFDHLEEGWFKHDGEFAIDPKAVKARATKLRQWLKARPEKEIAMVSHGFFNHYLCEEVDDDGQQTTPWWNEAELRTYTFSDDENDNIAKIYETPESLTARGASAGNERPMSPKVNIPSTRGSNPDEHYIKPDDSATASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M3D6M4</accession>
    <name>M3D6M4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNI-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_42192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761645.1">
        <property type="nucleotide sequence ID" value="XM_016908863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D6M4"/>
    <dbReference type="GeneID" id="27906000"/>
    <dbReference type="eggNOG" id="ENOG502S5T4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_467092_0_0_1"/>
    <dbReference type="OMA" id="IKLACHD"/>
    <dbReference type="OrthoDB" id="9876299at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF13524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="633" mass="69297" checksum="88A7B9BDF359315B" modified="2013-05-01" version="1">MGKSNKFDYSNRPNSGAKLGSIIGRDIEKEADKVVKDVERRARKSSTASSISAIGSLDITEALVHPLDIKAPSKQLGDEGACALAAGLEAALKAGTTRSAAVLLEDLNLSDNAITTITLAQLGPVIQRARYDLKTLNLANNNIRVENDQEAADWEIFLRSFEHCLKMRRLDLSGNRNLGARALEILARVHAQEPQINPVCARGDTSVISLDNEETHCQDEASSAHRDDAMTSGGIVKRRCGLRGIPYLTFTNVGLNDTGALWLSYVLEEHHYPIQLIDFLNATAANSGIKTYAQEAASLGLDWSTQEPLLSKDGVNLLKKTEAVRRQLMFDDGSIIEASMTEGLENTRARTHDRRGSIRSIATADGGEHELSELESLRTKLMRHIIADTGVAQVELWHTGLRAAISATVLTGLGPRVRDRNPAVFYTGPPLFRSSSTCNHPQPGNETRLQTPSNSSHGSPKSPGASRQGTYAHTLTATTIASTGEPELALTEVTNTPTTPRMIFKPHRKGAFSDGSDLQAVNQKLESLDVGDNGPHRFVRWQEDMVGRRGGSCVFRNTSVPSHLPKHLMDRIVGYTVTERKWQLLAEKQRRAVCAWGQNRNNFGASESWRKMPASSQVVSLLEVIECQSYRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M3D702</accession>
    <name>M3D702_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_149048</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762041.1">
        <property type="nucleotide sequence ID" value="XM_016905306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D702"/>
    <dbReference type="GeneID" id="27902443"/>
    <dbReference type="eggNOG" id="ENOG502T0Y1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1008908_0_0_1"/>
    <dbReference type="OMA" id="HEGNGRI"/>
    <dbReference type="OrthoDB" id="5385189at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF13920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="276" mass="31379" checksum="BEAE1B138725F5EB" modified="2013-05-01" version="1">MALRVEERWLWLGLGVFVVAAAAKGIHHALTDMVRFTELDPAQFPADDHHRHHGKHPDECVDLRTLRTLCMSPNPSIAAAAQSLVMRRFAALPNAAEILTRDRESEDPDTSRKAVQAIKYLRDYDMEFGISMPPHMSLDDTMDFLNTMNHDPDVAVDEVTYRDENGESTVMHGTDWDSMARELNRRQHAFDADRGFDVVARLEELSEEIARTERNTGLLQARIGWDGSSASREPFAITGGGRDERRRRHREVMVLHEGNGRIEEEDIISPSSLRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M3D7V6</accession>
    <name>M3D7V6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADH dehydrogenase I, D subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_65335</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the complex I 49 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762060.1">
        <property type="nucleotide sequence ID" value="XM_016909714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D7V6"/>
    <dbReference type="STRING" id="692275.M3D7V6"/>
    <dbReference type="GeneID" id="27906851"/>
    <dbReference type="eggNOG" id="KOG2870">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015134_1_2_1"/>
    <dbReference type="OMA" id="TRMDYLT"/>
    <dbReference type="OrthoDB" id="1009at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.645.10:FF:000005">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="entry name" value="Cytochrome-c3 Hydrogenase, chain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01358">
        <property type="entry name" value="NDH1_NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014029">
        <property type="entry name" value="NADH_UbQ_OxRdtase_49kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022885">
        <property type="entry name" value="NDH1_su_D/H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01962">
        <property type="entry name" value="NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004739">
        <property type="entry name" value="PRK06075.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993:SF10">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 49 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="HydB/Nqo4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00535">
        <property type="entry name" value="COMPLEX1_49K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NADH-quinone oxidoreductase subunit D" evidence="6">
        <location>
            <begin position="212"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF13939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="482" mass="53724" checksum="CCA861EA7D76C5EC" modified="2013-05-01" version="1">MAAPLTRLVATSARRAAWTASHCAPRSTVSGSVSSSSSSASLRCLSTTPARRYATPHEAANPNATRLVAADPASFGAGQDFNVPSDHTKSPDERKIRHYTVNFGPQHPAAHGVLRLILELNGEEIIRADPHVGLLHRGTEKLIEYKTYLQALPYFDRLDYVSMMTNEQCFSLAVEKLLNIEIPERAKWIRTMFAEITRILNHLMSVLSHAMDVGALTPFLWGFEEREKLMEFYERVSGARLHAAYVRPGGVSQDLPVGLLDDIYQWATQFGDRIDETEEMLTDNRIWLGRTKGVGVVSAKDALDMSFSGVMLRGSGVPWDVRKSQPYDAYDQVEFDVPVGVNGDCYDRYLCRMEEFRQSLRIIHQCLNKMPAGPIKVEDYKIAPPPRAAMKENMEALIHHFLLYSKGYTVPPGETYSAIEAPKGEMGVFVVSDGSERPYRCKIRAPGFAHLACFDQVSRGHLLADAVAIIGTMDLVFGEVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M3D906</accession>
    <name>M3D906_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sterol-binding-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_148288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762751.1">
        <property type="nucleotide sequence ID" value="XM_016904827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D906"/>
    <dbReference type="STRING" id="692275.M3D906"/>
    <dbReference type="GeneID" id="27901964"/>
    <dbReference type="eggNOG" id="KOG4170">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105945_0_2_1"/>
    <dbReference type="OMA" id="WTIDMKK"/>
    <dbReference type="OrthoDB" id="10265837at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1050.10:FF:000001">
        <property type="entry name" value="Putative Non-specific lipid-transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="entry name" value="SCP2 sterol-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003033">
        <property type="entry name" value="SCP2_sterol-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10094:SF25">
        <property type="entry name" value="SCP2 STEROL-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10094">
        <property type="entry name" value="STEROL CARRIER PROTEIN 2 SCP-2 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02036">
        <property type="entry name" value="SCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP2" evidence="1">
        <location>
            <begin position="19"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF14630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="128" mass="13662" checksum="F48242F6C220E999" modified="2013-05-01" version="1">MGLKDDAFPSSEAFDTIAAALSSEKDKKDAVKQGNAIFAFNLKNAQGHEKAWHLDLKETGNVGEGLAPSGKKADVTLNLSDENFAKLVSGKANAQKLFMSGKLKVKGAVMKATKMEPILKKAQTKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M3D9T0</accession>
    <name>M3D9T0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nuclear pore complex protein Nup85</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_63194</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Functions as a component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the nucleoporin Nup85 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762755.1">
        <property type="nucleotide sequence ID" value="XM_016909628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D9T0"/>
    <dbReference type="STRING" id="692275.M3D9T0"/>
    <dbReference type="GeneID" id="27906765"/>
    <dbReference type="eggNOG" id="ENOG502S1N1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002336_1_0_1"/>
    <dbReference type="OMA" id="YKPSPAC"/>
    <dbReference type="OrthoDB" id="5422384at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011502">
        <property type="entry name" value="Nucleoporin_Nup85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13373">
        <property type="entry name" value="FROUNT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13373:SF21">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07575">
        <property type="entry name" value="Nucleopor_Nup85"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7 9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF14634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="996" mass="109715" checksum="2DF860CC7D55AA23" modified="2013-05-01" version="1">MSFFGPPSTPGRSVHTHQSTTPAGQPPTWLEHTGKSTTPAGEPPRSSRFGRSSYNPTKSPNRFARKKPGFSVPEDDDDDFSDDDDDDAMDAGDSKYDFRESAQSGFHPRPAAPTPPRGLKRDAYGTVRENSGIAEVARSTMSNSRPAALAEPDIVILQSEHIVSEIDAKIQRRVIEGEAALVESVTELTKTWRQHSDVQTKAGAIGPKAKDSFTQANYLASLLLQLHHPHTNTRQPQPGGRLRNGSVPPPSHNATVPRALLEWLETYHQPFPDDYDAVHLNEPAPSAHESFWDIVYANLLRGHIGRVIRLLADAKWDYADTALDDGADHPGYHGRQYDNVVEVVQDCINVLGECPGHRYSNWDVKSTEWAVFRGRVKAVSDELEAFAEGDDLGESLNGENVFQRSLGASMNMSTASRRASSRVPWTIYENLRLIYGLVLGQPDQILMTSQEWLEAALYLTIWWDGSDESDLNASANPNPIKRGRDRTREVDVAPLAAYRRRLADAYLRVQDQTIEDDKTGRQILDTVFRPDTTDTVQVGLGCIMEDQVSSVIGILRTMSMPVAVSVVEVAALGGWLPLARPSSRGGALSQEGLSQEDLLVLSYGAPQENKDEVSRDEILIEYADLLAGKETISDKDGWEMAVAVLNRLDQTATANTKIGDLLDRLPLTNDTTVDKVLDVCDRLEQHEQRRSIAERYADHLAENTKSYGLALIYYARAQAKEKLKDTVSLLTSLCLLHSVSMPAARNIDPKLQSLISHERVALTDLGHVDLEAAQLLASHLSGYAMLRKFYDLRDQDMLANSASPLKPLERRRQAAASLSAVMKSAADCIPGGLFDPEAETVIPAEGILALFGECLPFLGQDKRIFTQQHVFGLLAILEDFIAAPPRIRENAESLLSASLGAYRDEINTGTGPFGQKGRGKQNSQEDLSKSVGSSWELMAESVAIDAQKGERIQRAWDWRQGLVDGGIGGSEEEVVSLVREALVREVARGWGGRINW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>M3D9W9</accession>
    <name>M3D9W9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SEPMUDRAFT_148316</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. Its motor activity is directed toward the microtubule's plus end.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 11">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762800.1">
        <property type="nucleotide sequence ID" value="XM_016904845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D9W9"/>
    <dbReference type="STRING" id="692275.M3D9W9"/>
    <dbReference type="GeneID" id="27901982"/>
    <dbReference type="eggNOG" id="KOG0240">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001485_3_0_1"/>
    <dbReference type="OMA" id="FPMGTKQ"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23649">
        <property type="entry name" value="Khc_CBD_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01369">
        <property type="entry name" value="KISc_KHC_KIF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000031">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059182">
        <property type="entry name" value="Khc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF75">
        <property type="entry name" value="CENTROMERE-ASSOCIATED PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 10 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="14">
        <location>
            <begin position="7"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="400"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="470"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="676"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="859"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="775"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="490"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="677"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="861"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="909"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="89"/>
            <end position="96"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMF14679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="929" mass="103045" checksum="98D82C5C9CAE43D7" modified="2013-05-01" version="1">MATASNTIKVVARFRPANKVEQSNQAVSIVEFPSEDSVTIDSQEASKPTYTFDRVFPVGTAQHEIFDYSIKSTVDDVLAGYNGTVFAYGQTGSGKTYTMMGAGNLHDPDSKGIIPRIVEQIFTKIMQSDSTIEFTVKTSYMEIYMEKIRDLLVPHNDNLPVHEDKQKGIYVKGLHEFYVGSVDEVYEVLERGGQARAVASTNMNQESSRSHSIFVIEVTQKNVETGSARSGRLYLVDLAGSEKVGKTGASGQTLEEAKKINKSLSALGMVINALAEGKSQHIPYRDSKLTRILQESLGGNSRTTLIINASPMSYNDAETIGTMRFGERAKTIKQKAKINEELSPAQLKAMLKKTQTQVSTFTAYIQSLESEVGQWRKGEAVPKERWIPALSAGFQIAADVPPRSQTPTSRLKSQDGVGTPRSESRLDIERVGTPSLVLDKDEREEFLKRENDLQDQLAEKERELEAAQQAARAAQEQLKESRSTQLDLQRNNEKLSGETESLKREIERIDFETKEASITMDSLRDANSELTAELDGLKSELLDARMSAKESSALLDEKERLKKERMAQMMATFDLGEGLMSHNEMQIGEMVQQVQSLLEIADNGEAVAPDELSNLKDRLLEVQGQVRQADISASSHSDNSQVALLEQKLSQLRQEQQELLERHLSAADVEELKQKFSESLSEQQNGGTQSAETHEMLSRQKEENARLRNEVEALRKQAVNGANGGTLGKQLADFDAIKKSLMRDLQNRCERVVELEISLDSTREQYNSILRSSNSKAQQKKLAFLERNLEQLTIVQRQLVEQNTQLKKEVAIAERKLVARGERIRGLEGLVQESQEKLMLANHKFESQLMAVKERLEAAKSGSTRGLPNSPAPSQFSNTPFGRIAKPLRGGGGGGDGPSLAPTYAGLQQAASDNGGNKRSSWFFSQRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M3DAA9</accession>
    <name>M3DAA9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alcohol dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="9">1.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SEPMUDRAFT_148407</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a primary alcohol + NADP(+) = an aldehyde + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15937"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:15938"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:15939"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.2" evidence="9"/>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762930.1">
        <property type="nucleotide sequence ID" value="XM_016904906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DAA9"/>
    <dbReference type="STRING" id="692275.M3DAA9"/>
    <dbReference type="GeneID" id="27902043"/>
    <dbReference type="eggNOG" id="KOG0023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_20_2_1"/>
    <dbReference type="OMA" id="RNEWGIA"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008106">
        <property type="term" value="F:alcohol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000158">
        <property type="entry name" value="Zinc-binding alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="13">
        <location>
            <begin position="37"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="12">
        <location>
            <begin position="196"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMF14809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="364" mass="39419" checksum="B727770598092A31" modified="2013-05-01" version="1">MAATTDYKFEGWMGLDKDSAQGKMVWQEFPKVKTWEETDVDIQISHCGICGSDIHTLRSGWGPTPYPVCVGHEIVGKAVRVGSKVGKGIKVGDRVGVGAQALSCLKGDCEECQNGMEQHCQHTVNTFASPYPDGQMSYGGYADYNRTNSHFVFKIPEEIPSEDAAPMLCGGITVYSPLKQNGCGPGKRVGIIGVGGLGHFGVLFAKALGASRVVGISRHTDKRSDVLSMGADEYIATSDEPDWNKTHARSLDLIICTVSSPSMPLMKYLQLLRVKGTFIQVGAPEDKLPDMNAFAFIAKGVKFGGSMIGAPHEIEEMLKLAAEKGIKPWIQSVPMKEANRAVVDMDAGKARYRITLVNEKFAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M3DAY3</accession>
    <name>M3DAY3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Metalloprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_36825</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M43B family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763125.1">
        <property type="nucleotide sequence ID" value="XM_016908649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DAY3"/>
    <dbReference type="STRING" id="692275.M3DAY3"/>
    <dbReference type="GeneID" id="27905786"/>
    <dbReference type="eggNOG" id="ENOG502QQ7Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048726_0_0_1"/>
    <dbReference type="OMA" id="ECYERFT"/>
    <dbReference type="OrthoDB" id="536211at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04275">
        <property type="entry name" value="ZnMc_pappalysin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008754">
        <property type="entry name" value="Peptidase_M43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47466">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47466:SF1">
        <property type="entry name" value="METALLOPROTEASE MEP1 (AFU_ORTHOLOGUE AFUA_1G07730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05572">
        <property type="entry name" value="Peptidase_M43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 11" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M43 pregnancy-associated plasma-A" evidence="10">
        <location>
            <begin position="127"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF15004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="274" mass="29315" checksum="8CFA631235C1A592" modified="2013-05-01" version="1">MTIRRFDCGTTRAKASAHFNATTKFLARNGRRPGQIPAVSKRAAVTPAITIDTYLHLLTTTAAAGTLTPDMATAQVAALNKAYNRIGITFNLVNVSTTVNDTWAIADGTAMDDLKKALRAGSYRDLNLYFHSDPAGGILGTCTLPSQVTAQTTAAEYYTDGCNINGHTMPGGSLTGYNMGMTAVHETGHWLGLLHTFEGYSCDGEGDLISDTPMQSTSTDGCPAKPPKDSCPSKTGVDPIHNYMDYSSDACYSQFTPGQVARIQSLWGTYREGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M3DC90</accession>
    <name>M3DC90_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">intramembrane prenyl-peptidase Rce1</fullName>
            <ecNumber evidence="10">3.4.26.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SEPMUDRAFT_123723</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>Hydrolyzes the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic sidechains and P3' is any C-terminal residue.</text>
            <dbReference type="EC" id="3.4.26.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase U48 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.26.1" evidence="10"/>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763545.1">
        <property type="nucleotide sequence ID" value="XM_016901857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DC90"/>
    <dbReference type="STRING" id="692275.M3DC90"/>
    <dbReference type="GeneID" id="27898994"/>
    <dbReference type="eggNOG" id="KOG4130">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049909_1_1_1"/>
    <dbReference type="OMA" id="HSFCNWC"/>
    <dbReference type="OrthoDB" id="271604at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039731">
        <property type="entry name" value="Rce1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1/LyrA-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13046:SF0">
        <property type="entry name" value="CAAX PRENYL PROTEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13046">
        <property type="entry name" value="PROTEASE U48 CAAX PRENYL PROTEASE RCE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="226"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 2/Lysostaphin resistance protein A-like" evidence="13">
        <location>
            <begin position="159"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="296"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMF15424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="371" mass="41233" checksum="68F187022DAED6CF" modified="2013-05-01" version="1">MPLPSRDYYRWLGNMKEFYWNKKEPPPSISERTALLCGLLFTAFFVAPFYLSPTLRATPLTSRDAPAVIKARVRAVGLSCIASTVVTVYVLVSSGHSTPRDVLRLLAVWPINLPDCAKTLALLSILFIGPLYETILVDSGWRQWNLATFKDRFFTDLRGLRNNVVAPWAEEWVFRSLVVSLYLVAKVSPTRIVFTTPLIFGAAHVHHLVEFVMSGTASGQSSFGKILLLGLARSFFQFTYTTLFGFFAAFLYLRTGNVFAAVTAHTFCNFMGFPRVLGRVGQTEDYQAYEMTPDVAQGKKSDDGGQVRVGNSLMQDKDEGGNATAGLEGLKPRGLGVQWTVLYYMLLVAGSYGFYELIWPLTESSNALASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M3DD78</accession>
    <name>M3DD78_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_61001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763900.1">
        <property type="nucleotide sequence ID" value="XM_016909547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DD78"/>
    <dbReference type="STRING" id="692275.M3DD78"/>
    <dbReference type="GeneID" id="27906684"/>
    <dbReference type="eggNOG" id="ENOG502QU1B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018354_4_4_1"/>
    <dbReference type="OMA" id="APPANCF"/>
    <dbReference type="OrthoDB" id="9983560at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF91">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G12070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004033230" evidence="3">
        <location>
            <begin position="21"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="131"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF15779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="609" mass="64535" checksum="6E90A6E663339EF1" modified="2013-05-01" version="1">MASLLGFTASLACLFSYALATPLAGRASTPISQITPSQWQALNSTVSGRLQTATPVAKPCYSYYNGVFTTPDLQQCKAVQDGYTTEDSIVANFGGYQYPNWASCQAKGQSCGLDFTAPQNPAYYAPPANCFQGSVASYYINVQAVSDIQAALKFANQYGIPLVVKNSGHDFKGRSSAPNSLALWTHNIQPPIALTRGFTPDGCSAPVADAVTFGAGQGFAGVYEFAEANDITVVGGSSRTVGPAGGWISGGGHSALSNTLGLGVDNVLQIRTVLPNGTYITANRCQNQDIFFALRGGGGNTFGVNWEMTTTAHPKMQLEVAYITFAGTNASSIRRFIDICTQLGDRWATDGWGGYIAPGAVTSLVSGMIMMTPKLTHDQAIASMKPLTDYVASLGNVATHNSVTTEPSYYTAYQKYIAPNQEKVGVGIAMGSKFVPRSMLQSSAGQQKVADAIEKSSSMVIPVTGQGGVDYRSLTYGSPFQILVTAPSSYQTDGSSSVTPAWYGANGAAWHVCLGQGITNDASADTITAAFRNANQATQVLRDAVGSPGAYLNEADTFEPDPVSTYWGSDNYNKLLALKKQLDPNNVLTCWQCIGWDSSDARYGCYPRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M3DE22</accession>
    <name>M3DE22_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">LamB/YcsF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_38762</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF16000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764121.1">
        <property type="nucleotide sequence ID" value="XM_016908718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DE22"/>
    <dbReference type="STRING" id="692275.M3DE22"/>
    <dbReference type="GeneID" id="27905855"/>
    <dbReference type="eggNOG" id="ENOG502RG2S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069535_1_0_1"/>
    <dbReference type="OMA" id="VCIHGDT"/>
    <dbReference type="OrthoDB" id="21128at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005501">
        <property type="entry name" value="LamB/YcsF/PxpA-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003814">
        <property type="entry name" value="PRK05406.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30292:SF0">
        <property type="entry name" value="5-OXOPROLINASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30292">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YBGL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03746">
        <property type="entry name" value="LamB_YcsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF16000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="254" mass="27905" checksum="39407F214BF73740" modified="2013-05-01" version="1">MAPIQKKVHINVDLGEGYGNFKAGPDDELIPLIDHANIACGFHAGDPLIMQETVLKCKQHNILIGAHPGLPDIQGFGRREIKMSSEELTAITRYQIGALQAFLSAFDLSLNHVKPHGILYGMMYRDREICRAVYAGVPPGTRVFGLAGTFHEEVAKEMGLPFTAELYGDVKYSADGRLVIDRKKKPWTAEEVHKHVSSQVENSSVTAVTGEEVELPIGQHDVSLCCHSDSPGALEIVQAAREIVDAFNNKMNYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M3DE67</accession>
    <name>M3DE67_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA/rRNA methyltransferase SpoU type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_61582</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF16065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764186.1">
        <property type="nucleotide sequence ID" value="XM_016909567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DE67"/>
    <dbReference type="STRING" id="692275.M3DE67"/>
    <dbReference type="GeneID" id="27906704"/>
    <dbReference type="eggNOG" id="KOG0839">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005519_0_0_1"/>
    <dbReference type="OMA" id="YCLGIIR"/>
    <dbReference type="OrthoDB" id="241340at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016423">
        <property type="term" value="F:tRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18091">
        <property type="entry name" value="SpoU-like_TRM3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045330">
        <property type="entry name" value="TRM3/TARBP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044748">
        <property type="entry name" value="Trm3/TARBP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12029:SF11">
        <property type="entry name" value="METHYLTRANSFERASE TARBP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12029">
        <property type="entry name" value="RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="tRNA/rRNA methyltransferase SpoU type" evidence="4">
        <location>
            <begin position="1102"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="564"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF16065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1258" mass="140389" checksum="D5FFC7F4E93D5C10" modified="2013-05-01" version="1">MTSIRAQTAHLLLDRISPDEQIHLVRDVAHSLDARSGKSDLSFAATLLQLRPDAEASKSLFSHLRNLVEFGQMDPVAAVCIEYPEMGNEVLSQACVQIRDAANVLREASKEHFPVPVSGPEAVVVADQSSSSSSSVDGNVQPVVDTIVVTCTHSLRLVNRLSSHAVFAGRIDDLFRPALVLLGAANRELRLQAQETLFLLMARRDRLSREDQQSIWMRVQDLTRSADKFYQALGYSLWLRWITSSAAVEPIILQSEQYWSSLINGLRYGDSERRKSSLQILRASVKAAVEDPELLSIVAASSHSNEFLPMLNADRNLAPATVQKHYARYCTVYETVVLGRYLNQVQECEADMDFLSSDKSAVKPVWLYTLLTCALDQKMQDSNRKLIGSWVMDAVPRVDGTTEYLNFLQDAFLPWATLGYLFTNTLRREDGVLYCEHGNKLSSFIFKLLSNNPDLLGPAVEAILASISGRHGNRFAQAKVYLIDGIARAVQENPGLSISPAHLEKMYEIATWANLTEVARDYLFAQSWKMCHDYAKRQSSKTLTEFVNVSAKKWDDLTEKARGLSSNASAEQDGTIGSMALPPSNREKNEEKAQQRCIAFLKLVESGRTPRPEADAVEEELSEIWNDLEYLEYPKGLTLSMTKVFLDHDLLQFALETNSSSLSRLLSAKVEKLLRLSEPRSYLLGSLVESVRAVVLRLPSAASLLNLSALIVHLAQHPPSTSIDMQLDEALVPLLPGVSSELKNFNHEFYFGHREAIGFAGLLDLSSRLHTIDAKLPRETFDTLFAPWYTQKIPPNVVSTWKTVLELQVMLLCCEQFVPHAASEEVRALLTKIQYVLSVEPLPRYRYLLEWMVARIYIHHPELRDVIFQELRTKDHHSNPKFLASLMKIGVRIAKSEGSDLVFASQLATLFVPLAASSKVVIRHEAQWQVPILLEHVREMQSDAGMRNPAFEALDDYIRSLERFDDPPVERQIGNFDPIKHHNLTHLVEGPWHELDEHEKRLCSRSDFLTLYANDDHDSPSLPPSCIPLGDSTTLIHRPALPTQQEKPQPPKDLESRTLQNITAISRALNTEVTTTTPTPALQTKGAAYLSSQTSRKRPPTLLVIASLVDNPYNLGGLSRVSEIFGAKTLYIENPRLTTSSKDFTSTSVSSHLHLDIQPLPPASLAQFLAAKKREDGGGFYVVGIEQTDRSAILGSKECVLPEKCVLVVGSEREGIPAVVLAECDLLVEIPQVGITRSLNVQTAAGIVLCEYVRQHAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M3DEC3</accession>
    <name>M3DEC3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_61742</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF16145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764266.1">
        <property type="nucleotide sequence ID" value="XM_016909574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DEC3"/>
    <dbReference type="STRING" id="692275.M3DEC3"/>
    <dbReference type="GeneID" id="27906711"/>
    <dbReference type="eggNOG" id="ENOG502SN7Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_350259_0_0_1"/>
    <dbReference type="OMA" id="NYYMEAK"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024319">
        <property type="entry name" value="ATPase_expression_mit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12921">
        <property type="entry name" value="ATP13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="61"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF16145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="733" mass="83578" checksum="E2FE99DFA425A99E" modified="2013-05-01" version="1">MLFFLLGRTGHRESRRVLQVVWNIGQGQGKRADGASHKPTLAQRRGYGDDVLKWPGQHVLRDDDDARDAGSKSTWGLSWDNNTGRDRREHLGHPEGEGDEGDEGDAILPQNRTRDDLLGIESQLDLWERFESETAQGPYTPAQKQTEADEEAPEPAILTNSLLDVDYKNELQPALDKRASDLVIRCLYAAAQVHDQDFLASISAPMFSQILELLEPNQFVAKLGTAHIELSTALAASMNIAPMREVAFEYNKTLLRILKDRRSTGHIPTLDDYVLLLRSARLLGSHKMAGIVWRSLLKDGIQPDTRCFNHYMASLVWNGMHSAGSRHKVRAIPFFMMARSAAHRDRRFSNYRVGDRGVKEETMKAFGEMLAFGAVADHESFQILITACARDGDIATVKAILQRVWGIDVQSIMEGKDEATIAPKSFSDDSPIRPQSSLLFALAHAFGINNDVPSALRVVDFVARHYELEITSEIWNQLFEWTFVLAHQRRPDAPENAGKLPIGSVLGLWETMTGPPYFIKPTLGMYSRLISNLVDRKYTSKIIEVMREAMPLHRADADAAHKARRRLAAAVQEGKPVDDIEMSRKEWEYTRMIHARNVFWLRRWVRQILTSLNIRNVFDGGKAKFLDELPRVLWEWRRYAPRKVQYEIASGFIDLEFHEERDASRRRSADRLHPLKEKSRRYVGNDWAVEHKMSDKNLEEREQRRCSKAAAREEQNFRRLVGGHLAKEFGSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDA1</accession>
    <name>N1QDA1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_120132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757387.1">
        <property type="nucleotide sequence ID" value="XM_016901574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QDA1"/>
    <dbReference type="GeneID" id="27898711"/>
    <dbReference type="eggNOG" id="ENOG502S8NB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138726_0_0_1"/>
    <dbReference type="OMA" id="FTAFINT"/>
    <dbReference type="OrthoDB" id="3913322at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045469">
        <property type="entry name" value="Nis1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19271">
        <property type="entry name" value="Nis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109738" evidence="1">
        <location>
            <begin position="22"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="151" mass="15792" checksum="103C0B29B2CFD683" modified="2013-06-26" version="1">MHSTTTLLTAAATLLASTAQARIVGFYAPQNAAPNADVKIEIFTEGYPQTINDVAISFGLTPLESLFMGSLGTYVSTKALGPDFSNVDGNITHIIHIPATFPVGPAVLQASHFSLTGASSTPATEIYYANVTIGAGNQFPYTTSARIPNPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDQ8</accession>
    <name>N1QDQ8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ADP-ribose 1''-phosphate phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_151607</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Highly specific phosphatase involved in the metabolism of ADP-ribose 1''-phosphate (Appr1p) which is produced as a consequence of tRNA splicing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ADP-alpha-D-ribose 1''-phosphate + H2O = ADP-D-ribose + phosphate</text>
            <dbReference type="Rhea" id="RHEA:25029"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57967"/>
            <dbReference type="ChEBI" id="CHEBI:58753"/>
            <dbReference type="EC" id="3.1.3.84"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the POA1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.84" evidence="3"/>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757792.1">
        <property type="nucleotide sequence ID" value="XM_016906923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QDQ8"/>
    <dbReference type="STRING" id="692275.N1QDQ8"/>
    <dbReference type="GeneID" id="27904060"/>
    <dbReference type="eggNOG" id="ENOG502S60W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054419_1_1_1"/>
    <dbReference type="OMA" id="CQGSWGK"/>
    <dbReference type="OrthoDB" id="2155246at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140291">
        <property type="term" value="P:peptidyl-glutamate ADP-deribosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02901">
        <property type="entry name" value="Macro_Poa1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050892">
        <property type="entry name" value="ADP-ribose_metab_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12521:SF0">
        <property type="entry name" value="ADP-RIBOSE GLYCOHYDROLASE OARD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12521">
        <property type="entry name" value="PROTEIN C6ORF130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="8">
        <location>
            <begin position="30"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF09671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="210" mass="22750" checksum="49887D7CDB2DE971" modified="2013-06-26" version="1">MSASFRLSQEVSKSQPDPSSSNSPGQQQQHASSSTDSTSSITLVESINDIFNAPPNTLIIHACNTKGSWGGGIAKAFKGKYPAAFEVYKTHCQRNGGELVGQALLIPPHKEAGEEHFVGCLFTSVSKGREADSPAKILSATGPAMRHLLRQVQEHNTTHPGEEVSEVRMCKINSGLFKVPWEKTKDVLQAIPTEPDGIRQIKVISRSEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1QE19</accession>
    <name>N1QE19_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_69736</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758652.1">
        <property type="nucleotide sequence ID" value="XM_016909872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QE19"/>
    <dbReference type="STRING" id="692275.N1QE19"/>
    <dbReference type="GeneID" id="27907009"/>
    <dbReference type="eggNOG" id="ENOG502SABA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027375_0_0_1"/>
    <dbReference type="OMA" id="FNNAWTA"/>
    <dbReference type="OrthoDB" id="3251668at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="483"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="292"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="445"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="526"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="456"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="528"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="540"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="580"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF10531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="617" mass="66415" checksum="7EF68F1D7D168383" modified="2013-06-26" version="1">MSRVSYGSRAGDATDYGGGGHVQFVGPRHAARAGPYDSLEALIAALRQEFDAAAESVMPVCTTLEMSLGLTAVIPLVRPGIGPYSEGGDHDLPFEFKNGLYEMEHDPGQKHPRAPCSAIINVTDARQKQVVQRAASRGIISAIEALDGFRYSFNNAWTAKDEEGARFSFICQDSMQNKDRHANGYTRILKHLKDPGGAERGPRKPTYDCKGSVSIKFSSSRQSCDVFYRHNAIHETVAARKPAARAAAAAKRTSSSWIRLPSAATPIAPQEEDTGGLSAMLQAETASSALALVKPPPAQSGPSTSNIGRPLKRKRDETAPPGRLSEQPLSLADLLRQSETAKAPPPTNENGGKSTPGAAAVAYELPSWQTPPPALRQSADGLPYPLPYQPKGRNMVVTALTPPSGTSAALKNPPHPKNFQQFRVSSSTPARKQSASQGLFTTMKMVPTNKPPLRWPQQSQRSAMSPPSATHFVAQSRHRSVLACTNCRLAKRRCDEGRPHCGPCSKTGRLDCKYEAPAGWRAIMSADSQQSPTQQNTSSALAQSTPNSAQPTTQSAQNIGQQSAQTSPQWQPPSAQNTNSQQWPSQSSPPLQTWGNITIASPNIVRPSSPDPWYPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1QE70</accession>
    <name>N1QE70_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable kinetochore protein NUF2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SEPMUDRAFT_144048</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NUF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757303.1">
        <property type="nucleotide sequence ID" value="XM_016903063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QE70"/>
    <dbReference type="STRING" id="692275.N1QE70"/>
    <dbReference type="GeneID" id="27900200"/>
    <dbReference type="eggNOG" id="KOG4438">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025461_2_1_1"/>
    <dbReference type="OMA" id="YLKMEAH"/>
    <dbReference type="OrthoDB" id="8194677at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051383">
        <property type="term" value="P:kinetochore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045132">
        <property type="term" value="P:meiotic chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.60">
        <property type="entry name" value="Ncd80 complex, Nuf2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010504">
        <property type="entry name" value="AH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005549">
        <property type="entry name" value="Kinetochore_Nuf2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041112">
        <property type="entry name" value="Nuf2_DHR10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038275">
        <property type="entry name" value="Nuf2_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21650:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN NUF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21650">
        <property type="entry name" value="MEMBRALIN/KINETOCHORE PROTEIN NUF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03800">
        <property type="entry name" value="Nuf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18595">
        <property type="entry name" value="Nuf2_DHR10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50870">
        <property type="entry name" value="AH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="13" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AH" evidence="16">
        <location>
            <begin position="280"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="334"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="169"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMF09182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="464" mass="54620" checksum="2FDEF464B86A3670" modified="2013-06-26" version="1">MEYNPRMSMAGGRSVSSQQQKKVKEPDEDAFMTLPDKEIAGCISDIGINFTLEDLRKPNPQQIQKVFEWFAELLTNTTREVVAPAMRAAAEDMCGDDVERIFTADTRELMGFFITMRKLLLECGIKDFTFSDLYRPTHPRLVKIFSYIINFIRFRESQTNVIDEHYNSSERTKNTIEQLYHANQEKEDRLHEMQQNRKNVEAALQQKEQRSQELKTRLLELKKAQERVTEKLERVKGEQSRLKSLLEDKTTSVMQTRNEAAKLRPYTEQSPAHLEQSLRDLSSNLAADRHEIERLDKRARALQTSCDTFTLLQTDISSLTRLLGDLQLELHKEDEEQRAAGKNRDALTEKSNSVREVERQEKMLRKQLQQWQDRTEKLRRDAETRALNAKSKMEALRAKHRELTAERRDRGEEIEKRRVRVEQTEKKMADLKEQIEHEVQAAREEYMKMESHIRLYITEMEQSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1QEF3</accession>
    <name>N1QEF3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lanthionine synthetase C-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_70158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016909891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QEF3"/>
    <dbReference type="GeneID" id="27907028"/>
    <dbReference type="eggNOG" id="KOG2787">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040560_0_0_1"/>
    <dbReference type="OMA" id="HEIKSMA"/>
    <dbReference type="OrthoDB" id="10257263at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031179">
        <property type="term" value="P:peptide modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04794">
        <property type="entry name" value="euk_LANCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007822">
        <property type="entry name" value="LANC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12736">
        <property type="entry name" value="LANC-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12736:SF7">
        <property type="entry name" value="LANC-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LANCSUPER"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158745">
        <property type="entry name" value="LanC-like"/>
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    </dbReference>
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    <feature type="binding site" evidence="1">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR607822-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF10745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="371" mass="41015" checksum="4FF912000287A1C0" modified="2013-06-26" version="1">MPPRYFKNDATPARRDPRRQLEASLTRLITEYPPSSIKPGGGLFKGPVSVAYAFLVLQGLYPDFEIEGHPLGVWSAAYLKHAQDNIASYPGPQVGKCGITDDILALLAIGAASSKDADMASDLCDYSAEVLEEDTENELLFGRAGYLYLLRLVKASFMDEPKTLQLITDTQDDVVDAILDTPRPWKWHGKAYIGAIHGAMGIITQVVLTNPKKYAEKLEAELAVLLTYQYDSGNFPSSVPPERDRLVQVCHGAPGVVTSLESIKEYFPNLKDRIDKAIMRGRECILERGLLTKEPCLCHGISGNALALETKDFEHFLTYTTGHEMKSMEKDGMLEQSSAPESLFQGEAGRAWTWAVSEKGLPKRILGYNDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>N1QEL6</accession>
    <name>N1QEL6_SPHMS</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_119418</name>
    </gene>
    <organism evidence="2 3">
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        <name type="synonym">Septoria musiva</name>
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        <lineage>
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            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016901506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QEL6"/>
    <dbReference type="GeneID" id="27898643"/>
    <dbReference type="HOGENOM" id="CLU_1120707_0_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF10906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="248" mass="26930" checksum="348B5EAC73FA4BE3" modified="2013-06-26" version="1">MSTWRPSGGLPMRGSLAEGRRPSSIASKVMSRAQASVQTSYAGAGAGAGNQTQTNDRAAAAVHLTVSSIGSAMSLEGLCTLQHCSPFRQPDQPSRPSRRHDPVHRRGPVSIIEDHRKDRQPASTPPCPCSTLPARLVRRGTGHQSTPTDMKTDVWRITGTSLLRHRLGLQLISRQQSYRLGAAYYTHTRSTSPMRLCETPKAPDQEPERPPCLTLAWSPSARSQSPATGPARPRQASQESSQRLIGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1QEP2</accession>
    <name>N1QEP2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Calreticulin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_150855</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the calreticulin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759021.1">
        <property type="nucleotide sequence ID" value="XM_016906439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QEP2"/>
    <dbReference type="STRING" id="692275.N1QEP2"/>
    <dbReference type="GeneID" id="27903576"/>
    <dbReference type="eggNOG" id="KOG0675">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018224_1_2_1"/>
    <dbReference type="OMA" id="SGCGKWE"/>
    <dbReference type="OrthoDB" id="1938156at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.250.10:FF:000001">
        <property type="entry name" value="Calnexin homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000011">
        <property type="entry name" value="Probable calnexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.250.10">
        <property type="entry name" value="Calreticulin/calnexin, P domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001580">
        <property type="entry name" value="Calret/calnex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018124">
        <property type="entry name" value="Calret/calnex_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009033">
        <property type="entry name" value="Calreticulin/calnexin_P_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073:SF1">
        <property type="entry name" value="CALNEXIN 14D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073">
        <property type="entry name" value="CALRETICULIN AND CALNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00262">
        <property type="entry name" value="Calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00626">
        <property type="entry name" value="CALRETICULIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63887">
        <property type="entry name" value="P-domain of calnexin/calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00803">
        <property type="entry name" value="CALRETICULIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00804">
        <property type="entry name" value="CALRETICULIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00805">
        <property type="entry name" value="CALRETICULIN_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110737" evidence="9">
        <location>
            <begin position="19"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="489"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="231"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="287"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="527"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="136"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601580-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF10900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="561" mass="61962" checksum="7BE64E00CEAD713C" modified="2013-06-26" version="1">MKFNSLLALGAVAATAYAADEDTTESAAAALEAALPAFTPTTLKAAFVEQFTDGWDARWKASHAKKENTEEEWQYVGNWEVEEPTVFKGLQGDKGLVLKDKAAHHAISAKFDAPIDNKDKTLVVQYEVKLQNHLECGGAYLKLLRENAALSQDEFSNASPYVIMFGPDKCGATNKVHFIFQHKNPKTGEYEEKHMNAAPPAKINKLTNLYTLIVRPDQSFEVLINGESSKNGTLLEDFTPAVNPPTEIDDKDDKKPETWVDEAKIVDPEASKPEDWDEDAPYEIIDESAEKPEDWLESEPLTIPDPEATKPEDWDDEEDGDWIAPQISNPKCEEVSGCGPWEKPMIKNPAYKGKWSAPLIDNPLYKGVWKPRKIANPDYFEDKTPANFEPIGAIGFELWSMNENILFDNIYIGHDEAQAKTFQKETFDIKKPNEEAAEKAAKPAADDKKSPSDLVFLEDPVLFVKEKTALFIELFQKSPMEAITFVPEVSGAIGVTLVTLLVLLFGLGGSAAPSKEQIKAKANQAKDAAQKTKNDVADAVASGADKAQAEVNKRTTRSGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2023-02-22" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>N1QEQ9</accession>
    <name>N1QEQ9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_119446</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759056.1">
        <property type="nucleotide sequence ID" value="XM_016901509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QEQ9"/>
    <dbReference type="GeneID" id="27898646"/>
    <dbReference type="HOGENOM" id="CLU_1908011_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF10935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="133" mass="14843" checksum="B760FAB212444137" modified="2013-06-26" version="1">MSNPASGIRDCEADSNNDDDAIEYEYLIKYQAENQQPVQEYDCYGDAKLDIGVLDQLPSAPFNYIYRMTVPSNSKKCVAVRMVPETCVVGKCPYGDLCNITPGLITAYQQSRGEAASIHFSENRGFKFHNDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2023-05-03" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>N1QES1</accession>
    <name>N1QES1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_128160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757623.1">
        <property type="nucleotide sequence ID" value="XM_016902196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QES1"/>
    <dbReference type="GeneID" id="27899333"/>
    <dbReference type="HOGENOM" id="CLU_2321832_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF09502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="99" mass="10400" checksum="940E9BE7ADEAA684" modified="2013-06-26" version="1">MAAHSVSALLQTPSSHAGPCSKLDEPCASAIDLPVLPPTTSNTLQLYCLCMYSGHDAPAPQCSQSNHQNILPTCHACCISTCCHWDLISTACGASQQNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>N1QEW5</accession>
    <name>N1QEW5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_117687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759834.1">
        <property type="nucleotide sequence ID" value="XM_016901359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QEW5"/>
    <dbReference type="GeneID" id="27898496"/>
    <dbReference type="HOGENOM" id="CLU_700509_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF11713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="394" mass="44323" checksum="09C7515764C00F2C" modified="2013-06-26" version="1">MATPGAEVRSRMAAVLQTVVPDDEKEQVLNASYTRVEFMNWAAKIPARPTTTTPLGEGSQSEPAEWTDAERASIREATLKDAEEELFMNQYPEASLERYKECANKRELYPKATIEHGIRDQRHQYCLDHGLEYVFQMAEPVLGEGCSREQQVKDGLPKNHFPRYRDTGFGRVELPKAPKMRRAPNLRHSRDGPLHPKSGGSPAWHLESSSQADESNVRTPVTGHIMTSERNRQPTRSRDLIEAQKNVPTQGLLLKIEEAARERHEEDHQKLVEIRKQSEPDFVDPYPTPPRDTTPPSNGRQLRSATKSPSKRKSESESSPSPKKPRLILHGPKPRKRCNCGQAKLDDMIACGGKACKVRGQGHPIPCVPRAAAPAAGEEQYRRECRPPSQSSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1QF49</accession>
    <name>N1QF49_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Long chronological lifespan protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_149673</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable component of the endoplasmic reticulum-associated degradation (ERAD) pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LCL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759918.1">
        <property type="nucleotide sequence ID" value="XM_016905702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QF49"/>
    <dbReference type="STRING" id="692275.N1QF49"/>
    <dbReference type="GeneID" id="27902839"/>
    <dbReference type="eggNOG" id="ENOG502S416">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142363_0_0_1"/>
    <dbReference type="OMA" id="DNYLCPD"/>
    <dbReference type="OrthoDB" id="2234316at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23996">
        <property type="entry name" value="LCL2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034543">
        <property type="entry name" value="LCL2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38425">
        <property type="entry name" value="LONG CHRONOLOGICAL LIFESPAN PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38425:SF1">
        <property type="entry name" value="LONG CHRONOLOGICAL LIFESPAN PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110724" description="Long chronological lifespan protein 2" evidence="5">
        <location>
            <begin position="20"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF11797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="117" mass="13093" checksum="F5DA27644EDA665B" modified="2013-06-26" version="1">MQFQAIVGALLLLISPAMAQFFNFGNMFGQQQQQQEPQNMGSDSQWYQQNYDGARCDKYLCPHTLSCVHFPHHCPCAFPKTEDKVEFGEGSMACVSKGGFKAGEAQRKIELARKGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFK3</accession>
    <name>N1QFK3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SEPMUDRAFT_46374</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760199.1">
        <property type="nucleotide sequence ID" value="XM_016908997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QFK3"/>
    <dbReference type="STRING" id="692275.N1QFK3"/>
    <dbReference type="GeneID" id="27906134"/>
    <dbReference type="eggNOG" id="KOG0600">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="OMA" id="FPHCDES"/>
    <dbReference type="OrthoDB" id="204883at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070692">
        <property type="term" value="C:CTDK-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045903">
        <property type="term" value="P:positive regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006413">
        <property type="term" value="P:translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07840">
        <property type="entry name" value="STKc_CDK9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000440">
        <property type="entry name" value="Serine/threonine-protein kinase bur1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000270">
        <property type="entry name" value="Serine/threonine-protein kinase bur1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF546">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="50"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="362"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="362"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMF12078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="413" mass="47193" checksum="90A4385EC708449F" modified="2013-06-26" version="1">MNARGSEFARARRSDAPSTRKEKVRKKRLKVKPELSDEYKQSESVYYRKTGNESVVGSGTYGKVYKAIHVYTGGMVALKKIRMEGERDGFPVTAIREIKLLQSLNHLNVVPLLEVMVERNDCFMVFEYLSHDLTGLLNHPSFALTPAHKKHLAKQLFEGLDYLHRRGVLHRDIKAANILISKTGELKLADFGLARFYQKRQKQDYTNRVITIWYRSPELLLGETQYGPAVDIWSAACVLVEIFTRHAIFPGDGSEINQLDKIYNVLGTPSRSEWPGIHELQWYELLRPTHRLQSTFAEKYRERVSPEAFELLQAMFLYDPANRPTAADVLEHPYFTIEEPKPAQVVELANLEGDWHEFESKALRKEKERHERDARRAAREGDKRKAEETPTGAAPPDAKKMKPPPGPAADVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFL7</accession>
    <name>N1QFL7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Histone H3-like centromeric protein CSE4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">CENP-A homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">CENPA homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SEPMUDRAFT_46635</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes. Replaces conventional H3 in the nucleosome core of centromeric chromatin that serves as an assembly site for the inner kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of centromeric nucleosomes, where DNA is wrapped around a histone octamer core. The octamer contains two molecules each of H2A, H2B, CSE4/CENPA and H4 assembled in one CSE4-H4 heterotetramer and two H2A-H2B heterodimers. Interacts with the inner kinetochore.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the histone H3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760143.1">
        <property type="nucleotide sequence ID" value="XM_016909003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QFL7"/>
    <dbReference type="STRING" id="692275.N1QFL7"/>
    <dbReference type="GeneID" id="27906140"/>
    <dbReference type="eggNOG" id="KOG1745">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078295_3_1_1"/>
    <dbReference type="OMA" id="VHLFEDC"/>
    <dbReference type="OrthoDB" id="842664at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005729">
        <property type="term" value="C:2-micrometer circle DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043505">
        <property type="term" value="C:CENP-A containing nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019237">
        <property type="term" value="F:centromeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030543">
        <property type="term" value="P:2-micrometer plasmid partitioning"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061644">
        <property type="term" value="P:protein localization to CENP-A containing chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000087">
        <property type="entry name" value="Probable histone 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45810:SF1">
        <property type="entry name" value="HISTONE H3-LIKE CENTROMERIC PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45810">
        <property type="entry name" value="HISTONE H3.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="15">
        <location>
            <begin position="38"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMF12022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="137" mass="15051" checksum="7F2CEF2735778A9C" modified="2013-06-26" version="1">MRGGRGGRNSTGGKGPRRSSGPAGAVSSEQQKKRRYKPGTLALKEIRRYQKSTDLLVAKLPFSRLVREVCLNVAPPGSEVTRWQSQAIQALQEAAEAFLVHLFEDSNLCAIHAKRVTIMQKDIQLARRIRGAWGGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFU9</accession>
    <name>N1QFU9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycoside hydrolase family 13 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_72078</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757524.1">
        <property type="nucleotide sequence ID" value="XM_016909969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QFU9"/>
    <dbReference type="STRING" id="692275.N1QFU9"/>
    <dbReference type="GeneID" id="27907106"/>
    <dbReference type="eggNOG" id="KOG0471">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006462_1_2_1"/>
    <dbReference type="OrthoDB" id="1740265at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033934">
        <property type="term" value="F:glucan 1,4-alpha-maltotriohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004574">
        <property type="term" value="F:oligo-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000025">
        <property type="term" value="P:maltose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11333">
        <property type="entry name" value="AmyAc_SI_OligoGlu_DGase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.400.10:FF:000002">
        <property type="entry name" value="Sucrose isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="entry name" value="Oligo-1,6-glucosidase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF179">
        <property type="entry name" value="NEUTRAL AND BASIC AMINO ACID TRANSPORT PROTEIN RBAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="6">
        <location>
            <begin position="99"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="34"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF09403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="686" mass="78490" checksum="90BD11D46AFA7468" modified="2013-06-26" version="1">MHPSIVTALAEFEQEVVDKDLRPALSGEILDGIHTASQQTRNGRASSSDEQAPIESLEPSLDNSHPTRESLNADSHVPSNALEIDAEGRPWWKGVVAYQVWPMSFKDSNGDGIGDLQGIISKLDYLKDFGIEMIWLSPTYKSPLDDWGYDISDYEDMHDQFGKLSDIEELIKEVHARGMRIILDLVVTHTSNQHAWFKESAKSKDNPKADWYMWADKRPGNRIKGELVEEPSNWRAAFGGSVWTHVPARDQYYIHLFLESQPDLNWHNAEMREAVYQSAIKFWIDRGVDGFRLDTANRFCKNPAYPDVEVSVPGKWQPGSQHYINGPEMHKWLKEIRVKMDRDSNGKDLMIVGELPLTPYEELLKYVHPDEKELSMVFDFDMVKLGNNDNPDEYAKHEVSNYMDHDESYTLPKFKDSVSKAQSLITESGAWGTVFMENHDQPRSIARYATPEHKYWRKAGKLLALLQTTLSGTQFIYQGQEIGMLNMPESWGVSEFRDPDAKIYVEDYSTNYRDMDPNARENAIHGVFKVGRDNSRTPMQWSAAANGGFTGSNPTWMKVNDNFSWLNVSAQQADADSIWNFWKSSVKMRKEFGELFQFGSFALYDYENPDMVTFTKMATTTGKKNCYGQMALVILNFSNQELELNTPQKHLLGHTYRMIACNVEVPGEKLQAWEGRVYIIRDGLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1QG67</accession>
    <name>N1QG67_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_49266</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758918.1">
        <property type="nucleotide sequence ID" value="XM_016909106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QG67"/>
    <dbReference type="STRING" id="692275.N1QG67"/>
    <dbReference type="GeneID" id="27906243"/>
    <dbReference type="eggNOG" id="ENOG502RX9H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027816_3_1_1"/>
    <dbReference type="OMA" id="KHIFMRI"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF683">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="141"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF10797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="455" mass="48895" checksum="777BB44D3FD40D2E" modified="2013-06-26" version="1">MLLDSKKAHEASLAPVSTNGLGEVESLAKSNDAPQDVFGQLSEDGPNYRDVGWAGTAILMFKTQVGLGVLGIPGAFDVLGMIPGIIMILLIAFMTTWAAWMVGQFKIKHPHVYGIDDAGRLIAGAFGRETISIAINSLSVHGACTAIFVAVAALIGFCFGSIQTLAKVSWIAWAGVAGILTAIFTLTIAVGVQERPAAAPQTGEYKSDYKLFGSPTFAEAISSVSTIVFAFSCLPAFFACYAEMRDPRKFTRSLCVAQGSVTVVYLCIGIVVYYYCGSYVSSPALGSAGTLMKKVCYGIALPGLIASCMLFIHMPAKTIFIRFMRNTRHLTSNTPIHWMSWLGCTGTITAVAYILGNAIPVFSQLLSLVGALLATITCFQPTGLMWLYDNSGWWQAENFSRPTRNWFFYFNFATAMLLIIGGTFVTVGGTYGAILEIINAERTSPWSCADNSNST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGC0</accession>
    <name>N1QGC0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_48877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759003.1">
        <property type="nucleotide sequence ID" value="XM_016909085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGC0"/>
    <dbReference type="GeneID" id="27906222"/>
    <dbReference type="eggNOG" id="ENOG502SKHH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069642_0_0_1"/>
    <dbReference type="OMA" id="MEFQPNG"/>
    <dbReference type="OrthoDB" id="5296889at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF10882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="273" mass="29682" checksum="3AF5B4D39A53B7C1" modified="2013-06-26" version="1">MSGGGGSNGYDAGALPGSSAKAEASPNLLIEAFNQAVRPFSDKIEGLEHEIADLRAYIASLERQQSEVHAWIDKRGLRPDVPPSIAQIMDSASHASSPTHAAATLNAQLDRKITIVNFDLHRLQDDLNDSLPTPSFSACMLKFLPDISRLSALPSGPRYAFDLLLKLGGNLNSHGGLENGDEDDIMERKSFYGRLDEAMVDVVNGRFREEADSWGVQREIKRIEKTGAYLRNWGVEPYFPKTLDVMRDGNRHHGSSSGPGQQAVPGGPAPDYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGC1</accession>
    <name>N1QGC1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-L-fucosidase</fullName>
            <ecNumber evidence="3">3.2.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_142489</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 29 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.51" evidence="3"/>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760473.1">
        <property type="nucleotide sequence ID" value="XM_016903003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGC1"/>
    <dbReference type="GeneID" id="27900140"/>
    <dbReference type="eggNOG" id="KOG3340">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002934_4_1_1"/>
    <dbReference type="OMA" id="NVRSTTK"/>
    <dbReference type="OrthoDB" id="6039950at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016139">
        <property type="term" value="P:glycoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016286">
        <property type="entry name" value="FUC_metazoa-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000933">
        <property type="entry name" value="Glyco_hydro_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057739">
        <property type="entry name" value="Glyco_hydro_29_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030:SF37">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01120">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00741">
        <property type="entry name" value="GLHYDRLASE29"/>
    </dbReference>
    <dbReference type="SMART" id="SM00812">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110302" description="alpha-L-fucosidase" evidence="7">
        <location>
            <begin position="20"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 29 N-terminal" evidence="8">
        <location>
            <begin position="370"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF12352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="820" mass="91470" checksum="8F70F7129E1F5C12" modified="2013-06-26" version="1">MFPFLWALFGSWPLASAYAELVIDTKTSPGQNGSFPSVPLDISPLRDNKAFAQEPSDPNFHGYIQNGGIPSVPLDIAPLRNNRAFAQEPRDADFDGYGRAYPAQYLPAEKLVYGGVDFIFPQYQPGGGFDNVLARGQILDISPGRYLAVHMLVATDSALVLTNLTGHYVDGSNATSGLTAFPWWSWPSAFSPWHYAGDLVFPFHFTNHTRDFNKSSIYRTVNWLDSAKDLHQVQLPNSTRLHIFAVSMVPASITSGTALLQVQLVRSTNTWFEGTDLQIFEAIILNVGTEWVLAEHGVEVIVQGTSDAIKTLRPAQIKRLRPGDETRVQIAVYSTPAVAATPQPQTATLVVFGKGIPPINYNFNATFGIHDYSPTEVSIYSHETPNWFNNGKYGIFIHWGPYSVPGWGNSGNIESFAEWYWWWMNSGPNSTRERTYEYHLETYGPNVVFDDFIQNLTASAYNPKDWVDLFADAGANYFVLSAKQHDGYALFDLPSNISMRTSVAQVPHRDLVQELYDAASTYHPHLYKGAYYSPPEWFHPDYHGFGDWPGGNATNPYTNETLPYLGYVPLSDYLREKVLPEMQILAAMGTDLMWCDIGGPNVTTEFAAGYFNNARRQDRQVAINNRCGIQGDFDTATYTTLQANRKWERTGSLDPFSYGYNRATPDDAYMKPQVIVTRLIEAISMNGNFLLNVGPTAEGIIPDIQQHNLRVAGSWIRSHSEAIFNTTFWSVSPVDKGNPAVRFTQTSDAFYILATQPPNSTLTLHSPVPYVTGDEITVVGGKLHGTVIPSELSQDGMLTLQISEKVREGDEFAWAFKISY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGN2</accession>
    <name>N1QGN2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4185 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_151644</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757849.1">
        <property type="nucleotide sequence ID" value="XM_016906950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGN2"/>
    <dbReference type="GeneID" id="27904087"/>
    <dbReference type="eggNOG" id="ENOG502SKHD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_727941_0_0_1"/>
    <dbReference type="OMA" id="VTAYTWV"/>
    <dbReference type="OrthoDB" id="2583188at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF09728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="432" mass="46913" checksum="75AD7FB24758CE41" modified="2013-06-26" version="1">MLLGLAGVAVLALAAPIPHISAPAVYMNTVAPRMKKATYLANVTNPALTRDSCGSARVGDRVLWTCRDTENYDVVARKLQALPIVTNTAAWTDLSVHGGPSLAAGPVGAASDGVKPILLMYGGDNLTLPAYFPVQETQCPDSGACEDGSRYAVWHDQPPLITHQYADGSAIAYTWIPNQQLKGINTCITENPSHSLFKQTYTPSADINAMPHVEVVAPRFYRENQIGFGRYGSMMYNNTAYLYGQTSDRHTVLARVSADQIENLSAYEYYQTTTHTWIDTAPVFNTSHEAITTPSSSGTFVSRIPLIAHIQSSYIIPNAGYGGQGTFYYSSYFSRFIWIGQSSGLDGTSAHFYITTAPAPEGPWEAPTILFAGENGDDAIAAAYTLQAHPALLPSGPEVASENGIYVTWTQQWQEGTVASRYVTPLVWLEFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGT8</accession>
    <name>N1QGT8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_145656</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764516.1">
        <property type="nucleotide sequence ID" value="XM_016903183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGT8"/>
    <dbReference type="GeneID" id="27900320"/>
    <dbReference type="eggNOG" id="ENOG502SB6P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_976669_0_0_1"/>
    <dbReference type="OMA" id="WEKMWEQ"/>
    <dbReference type="OrthoDB" id="2386090at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF16395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="297" mass="33215" checksum="B07B25DE13704C38" modified="2013-06-26" version="1">MPLISSLLRQAPRHPLSLRLHVPPPHLSAVLGRHIRPASSAALAIRNQKSSPLYPATINIYRSGTPATLSVGLTRMFTLVIFLVGTTIYAPGFYFSPEHSNWWIPTCIAVSATPAIAVSLLTGPMIHGIRVTLPDHVRRGGKDGLRRWSAERRGKENLPIELQFMRWAPWPKTRNLEFGELRRLRPSLKAGIANLQHVPREEVGNDPMAAKREDHRLLAGFMKRWTSRFYVKRDQAIDRAAVPGVWENLWYQIPFEEEGEGYGGRKEKSSDEGAAAGKGRAAPLRPLVPPMKSIARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGU3</accession>
    <name>N1QGU3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_129350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764521.1">
        <property type="nucleotide sequence ID" value="XM_016902281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGU3"/>
    <dbReference type="GeneID" id="27899418"/>
    <dbReference type="HOGENOM" id="CLU_540974_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF16400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="504" mass="55384" checksum="F46D8B7EE67420AF" modified="2013-06-26" version="1">MSRPPLGQTLFEFGCTCVLSAIANVLINKNDERIRQEREAEEAAVIEHEQLQIAFAKKESELRLQKQRAAESYQRLADELEISRQSFLNATTATTAAAPAHNITLGAGTGSLTPPPFALVVAAGLLALALLLSLCLPLSLCLPLRHMRKGHGRHRAAATHKPKKSRAEAGRASELAALTNDATLSGWQYVESLFRLDTLAAAFSSAELEITTLRTQRSEADLEHAVALAALQPRLDTLAASLASAELEKTTLRTQRSEADLEHAVALKALQTRLEEATASLVSKDLQLATHLKTKEAAASREQVQKDEAAKLRAARNAISSLKADHLPSIRTLANALKAAPMTTGDPKFSSGLEHLDAVLDCLERNSNGIVPAHRAEAQVEAMLGVISGGRFHFPQEYADRARLLLDDFRARNWGETSRPAAVEPQRDTTTPPEERKEQEAEVKQEEKKKEAEKSEDEEEDEEKQDGEGEKGGKKKKRRQPRKYGEDWRLRSLKALPFFSSSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGU9</accession>
    <name>N1QGU9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">homogentisate 1,2-dioxygenase</fullName>
            <ecNumber evidence="4">1.13.11.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SEPMUDRAFT_143072</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the homogentisate dioxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.5" evidence="4"/>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758494.1">
        <property type="nucleotide sequence ID" value="XM_016903024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGU9"/>
    <dbReference type="STRING" id="692275.N1QGU9"/>
    <dbReference type="GeneID" id="27900161"/>
    <dbReference type="eggNOG" id="KOG1417">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027174_0_1_1"/>
    <dbReference type="OMA" id="PGTIPHG"/>
    <dbReference type="OrthoDB" id="1689029at2759"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00339"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004411">
        <property type="term" value="F:homogentisate 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07000">
        <property type="entry name" value="cupin_HGO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000034">
        <property type="entry name" value="Homogentisate 1,2-dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046451">
        <property type="entry name" value="HgmA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046452">
        <property type="entry name" value="HgmA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005708">
        <property type="entry name" value="Homogentis_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01015">
        <property type="entry name" value="hmgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056:SF4">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04209">
        <property type="entry name" value="HgmA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20510">
        <property type="entry name" value="HgmA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase N-terminal" evidence="14">
        <location>
            <begin position="38"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase C-terminal" evidence="13">
        <location>
            <begin position="314"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF20510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMF10373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="486" mass="54227" checksum="B993295892F49588" modified="2013-06-26" version="1">MPAAAADSREYQDIFHWAETQKDGQIPSFGTRKNDPYEYQSGFNNSFASEAVPGTLPQGQNSPRNVRFGLYAEQMTASAFTASRALNKKAWLYRARPSVAHQGFTDLPDNPDMESNFLPINPRVHVSPTQLAWLPFEIPTGTDVNFVGGLKTLAGSGDPTLREGIATHIYAANTSMNREAFVNSDGDFLICPQQGVLDIQTEFGKLFVQPGEIVVVQRGQKFKVNLPDGPSRGYILEIWGSNFELPELGPLGANGLANARDFLHPVAHYDIEQADWGIIYKLGGKLFRCSQQHSPFDVVAWHGNYVPYKYDLTKFVNVGSISVDHIDPSIFCVLTARSRDPAAPLADFLIFSPRWDVASHTYRPPYFHRNVASEFMGLLYGEYGGRSDEFQPGGASYECGMVPHGVAYEQFKAATENEPPVMQISKGTVAFMFESSRPFTITDYAWNSDKKHVHAADMWDNLIDNFSQHQEEVQKLLAIRGSKHRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1QH72</accession>
    <name>N1QH72_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carbohydrate-binding module family 48 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_156736</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 5'-AMP-activated protein kinase beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759920.1">
        <property type="nucleotide sequence ID" value="XM_016907692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QH72"/>
    <dbReference type="STRING" id="692275.N1QH72"/>
    <dbReference type="GeneID" id="27904829"/>
    <dbReference type="eggNOG" id="KOG1616">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026512_1_0_1"/>
    <dbReference type="OMA" id="YYSASAH"/>
    <dbReference type="OrthoDB" id="531008at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000562">
        <property type="entry name" value="Snf1 kinase complex beta-subunit Gal83"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.250.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006828">
        <property type="entry name" value="ASC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037256">
        <property type="entry name" value="ASC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050827">
        <property type="entry name" value="CRP1_MDG1_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE , BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343:SF84">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04739">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01010">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160219">
        <property type="entry name" value="AMPKBI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Association with the SNF1 complex (ASC)" evidence="5">
        <location>
            <begin position="353"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="277"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="306"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="337"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF11799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="466" mass="50315" checksum="80C1F8FC5DA441C1" modified="2013-06-26" version="1">MGQADSRPARPLSSTSGSLPARSTPPRKTASQQQQPPPPPPPQEEPTASTESTESQPVAVPISNHSGPDELLQDDYIPTGYSESPYGLPAANYSRPPRLPLPIEEEEYRPGSPIINPQDVSAIKEDDIEGGAIPRIASVRSSTTVDDDDVGDNDAFDTSGLNHLLVKIPIKLAWNGGGDKIFVTGTFCNWEKKIKLPRNRDGSPGFSANVHLPPGTHHVKFLVDGEMVTSPDLPTTVDWTNILVNYIEVVAPLPEETQKQPAEPAKPMRIPGAAIAADQTTGTEEAAARQSAEQTLPAETAADLPSTLQATDGSTEQPVTAPVSIAGTPTPRQVEPQPVPETKPAPTPAPPKQRLPRPKYTNQIPQFLVDLDNYNNPEDERYQRAQRVTTTLPQPPSLPMFLNKSILNGATPHKDDASVLIMPNHTVLNHLATSSIRSGVLATSGTTRYKRKFLTTIMYKPTSDET</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1QH87</accession>
    <name>N1QH87_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NADPH-dependent diflavin oxidoreductase 1</fullName>
            <ecNumber evidence="9">1.18.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">NADPH-dependent FMN and FAD-containing oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">TAH18</name>
        <name evidence="12" type="ORF">SEPMUDRAFT_134857</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of DRE2, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins. Positively controls H(2)O(2)-induced cell death.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2 oxidized [2Fe-2S]-[protein] + NADPH = 2 reduced [2Fe-2S]-[protein] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67716"/>
            <dbReference type="Rhea" id="RHEA-COMP:17327"/>
            <dbReference type="Rhea" id="RHEA-COMP:17328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with DRE2; as part of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Mitochondrion</location>
        </subcellularLocation>
        <text evidence="9">Relocalizes to mitochondria after H(2)O(2) exposure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the N-terminal section; belongs to the flavodoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.-" evidence="9"/>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758639.1">
        <property type="nucleotide sequence ID" value="XM_016902665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QH87"/>
    <dbReference type="STRING" id="692275.N1QH87"/>
    <dbReference type="GeneID" id="27899802"/>
    <dbReference type="eggNOG" id="KOG1159">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_17_6_1"/>
    <dbReference type="OMA" id="DIMSIPR"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
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        <property type="term" value="F:FMN binding"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0160246">
        <property type="term" value="F:NADPH-iron-sulfur [2Fe-2S] protein oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
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        <property type="term" value="P:iron-sulfur cluster assembly"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="entry name" value="NADPH-dependent diflavin oxidoreductase 1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
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        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
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        <property type="entry name" value="Translation factors"/>
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        <property type="entry name" value="Flavdoxin-like"/>
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        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
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        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
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        <property type="entry name" value="FNR_nucleotide-bd"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR028879">
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        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF10">
        <property type="entry name" value="NADPH-DEPENDENT DIFLAVIN OXIDOREDUCTASE 1"/>
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    </dbReference>
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        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="Flavodoxin_1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
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        <property type="entry name" value="FPNCR"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Flavoproteins"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="FAD_FR"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0274">FAD</keyword>
    <keyword evidence="4 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9" id="KW-0288">FMN</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 9" id="KW-0521">NADP</keyword>
    <keyword evidence="8 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="10">
        <location>
            <begin position="31"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="11">
        <location>
            <begin position="239"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="37"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="84"/>
            <end position="87"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>FMN</name>
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        </ligand>
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        <location>
            <begin position="429"/>
            <end position="432"/>
        </location>
        <ligand>
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        </ligand>
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        <location>
            <begin position="470"/>
            <end position="473"/>
        </location>
        <ligand>
            <name>FAD</name>
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        </ligand>
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        <location>
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        </location>
        <ligand>
            <name>NADP(+)</name>
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        </ligand>
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        <location>
            <begin position="577"/>
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        </location>
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        <location>
            <position position="669"/>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMF10518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="669" mass="75057" checksum="F63A647A1BC48C20" modified="2013-06-26" version="1">MESVSYAEEVAEAGVAESKQVHHERLPNRTALILYGSETGNAQDVAEEIGRTTERLRFDTTILDLDSVQLRDLVKPTVVIFAISTTGQGEMPQNARGFWKKLLSSALKPGILRKLRFSSFGLGDSSYAQYNVSHRLVCGRLSQLGAQSFCERGEGNEQHPEGHNAGFREWILLLEQKLRDVFPLPENVEAIAEDVFIEPKWKLVRDTAGSGLHSSDQCKDQLTHSAKEAVPSSALLPIRDAYTATIDSNNRITAEDHFQDVRLLDLRVQEHLPYGPGAVAVVHPKNFPEDVQAFVELMRWHDIADVPLSLITNQDLAAKQLTTPSPLRHLDLTKVKLTLRWLLENVLDIMSIPRRSFFARLVYFAGDSTEDEAYQKERLLELANPELIDELWDYTTRPKRTILEAMTDFTLIKIPWQHALTALPIMRGRQFSIASGGAQKVDDCGRTRVQLLIAIVEPPSPIIKYRKRYGVCTRYIATLQQKQSISVCIQPGYLDVHPTELDVPAVMIGPGTGLAPMRSMIHERALWAENAHRPTSTSLQGDILFFGCRAEHSDYFFHEEWNSFAHANSLTVHTAFSRDPKHHPKAYVQDQIRAHGAHVYEALVQRNGKVYVCGSSGNMPKGVRQALVEVLATYSGGGGSSLSTAEAEEEAERYLQGMEKNGRYKQETW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1QHG8</accession>
    <name>N1QHG8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_145858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EMF16661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016903306.1"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_2374126_0_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF16661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="95" mass="10220" checksum="6C270345FD5E940F" modified="2013-06-26" version="1">MACSQMKGENAECPLTDQAMRNDGSSNMGQRRPSVPGDKSEPGMDSTMSACNECFTKGTSVPRTHWATFQAKNRHGKLGEDGTVVAEGGGWQRQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1QHS5</accession>
    <name>N1QHS5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNB-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_145949</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNR ribonuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764917.1">
        <property type="nucleotide sequence ID" value="XM_016903362.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.N1QHS5"/>
    <dbReference type="GeneID" id="27900499"/>
    <dbReference type="eggNOG" id="KOG2102">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002333_0_3_1"/>
    <dbReference type="OMA" id="QIQATHQ"/>
    <dbReference type="OrthoDB" id="372421at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048027">
        <property type="term" value="F:mRNA 5'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000900">
        <property type="term" value="F:mRNA regulatory element binding translation repressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008298">
        <property type="term" value="P:intracellular mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060237">
        <property type="term" value="P:regulation of fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903450">
        <property type="term" value="P:regulation of G1 to G0 transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.690:FF:000001">
        <property type="entry name" value="Cell wall biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.700:FF:000002">
        <property type="entry name" value="Cell wall biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000100">
        <property type="entry name" value="Cell wall biogenesis protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041505">
        <property type="entry name" value="Dis3_CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041093">
        <property type="entry name" value="Dis3l2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF9">
        <property type="entry name" value="DIS3-LIKE EXONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17877">
        <property type="entry name" value="Dis3l2_C_term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17849">
        <property type="entry name" value="OB_Dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNB" evidence="3">
        <location>
            <begin position="764"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="122"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="207"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="518"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="620"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1210"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1235"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="144"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="222"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="236"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="320"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="534"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="557"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="627"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1235"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1257"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1291"/>
            <end position="1305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF16796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1376" mass="150851" checksum="D6011C3A57CCCC7E" modified="2013-06-26" version="1">MDQQGQQQQQQQGPQGSAGRRLHIAHRRSPSEMTPLMMEQLALAQQIEMLQQQQQQIAATHQQYVNMGMIPQQQQLPNQFQQLQSQMQNLNVTQPGGFQFPQQAQMGQQHLGIPMTGGIAQPTGHRRNHSAMPNMGMGPPPAPSSGAAGSAFGDFGNFGQSRNENSAPSRGRGGGAAGGGHARRHSLALPEAKKAAELAEAKRKTSGFQFPIPGAPGVAAGDSTSTSNGAASPANTESTQAASTSSSRGSFAGRGHGRSQSMAVGSGRGMAPTSRGGPQGFQFPPPQATNDGGNVSELARRGSQGHGRTGSRNFEGNWRNPNPNSNEPQQNNMGSFQMNQQATAQPFQPGHRTRGSMANQSINSIQNFGGYNAQPQLMQLPQGQVLVQNPAIYGGQPLNALQLAQLQAYQQAGIQPPSLAQLTGQHNGPQLGPQQQQQRKTLFTPYLPQATLPALLGDGQLVAGTLRVNKKNRSDAYVTTLDLDADIFICGSKDRNRALEGDYVAVELLDVDEVWGQKREKEEKKKRKDVTDQRGGSMTAVNDATTQPESAQDGGLRRRGSLKQRPTQKKNDDVEVEGQSLLLVEEDEINDEQKPLYAGHIVAVIERVAGQMFSGTLGLLRPSSQATKEKQEAERQAREGSNSHRQPERQQERPKIVWFKPTDKRVPLIAIPTEQAPKDFVDKHQSYADQIFVACIKRWPITSLHPFGTLVEQLGTAGDLKVETDALLRDNNFGPDDFSDAVLKNVGHEDWSVAADGESALEGRRDFRDEKTFTIDPNGSKELDDAIHFKDLGDGHVEVGIHVADVAHFIKANSLVDREAKKRGTGVYLINRTVNMLPPKLSQDVICLLPGQDRYAVSVVFKVDAATGRVIDDETWVGKSVIRSSGKLSYEEVDAVINGNTASSLGEERAKQILTLYNVAQKLRKARYASDEADIPSLRLLYSLDDENVPVEHNIFDSSPAHEMIEELSHKTNAFVAEKLFAGLKERALLRTQKVPNTRRLHTFAERMSNIGYDMDISSSAALQNSLYRIEDAEVRKGMETLVFKTMARAKYEVSARADTPDNLGHFALNLPLYTHFTNPSRRYADIVVHRQLEAVLSSGAVEFTEDPETLHKTAEICNTKKDSAHNAQEQSVHIESCRRMNRLSEEQGGDLISVGIVVCVYESAFDVLIPEYGFEKRVHCDQLPLKKAEFDKHKRLLELYWEKGVPSSAFVPEDERPQAKGHRPTHSMVARDIAAKQRQADEAERKAMQTGSIDANDVDALFDDDDDDASEATGNTASDVALNGDRAAQNGPTSPTRNGSAPQRSKSDSRALKSSAPETRLTNKDKYLGLFTLREENGSYIQDVKEMTRVPVLLKTDLTKSPPCLTIRSLNPYAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>N1QHX4</accession>
    <name>N1QHX4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histone acetyltransferase ESA1</fullName>
            <ecNumber evidence="4">2.3.1.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Histone acetyltransferase esa1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15 24">protein 2-hydroxyisobutyryltransferase ESA1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 25">protein acetyltransferase ESA1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16 26">protein crotonyltransferase ESA1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="30" type="ORF">SEPMUDRAFT_151552</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30 31">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac. The NuA4 complex is involved in the DNA damage response and is required for chromosome segregation. The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) through homologous recombination. Recruitment to promoters depends on H3K4me. Also acetylates non-histone proteins. In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>(2E)-butenoyl-CoA + L-lysyl-[protein] = N(6)-(2E)-butenoyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53908"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:13707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:137954"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:53909"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>2-hydroxyisobutanoyl-CoA + L-lysyl-[protein] = N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:15921"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:131780"/>
            <dbReference type="ChEBI" id="CHEBI:144968"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:24181"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21992"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:21993"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:45949"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="4"/>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757705.1">
        <property type="nucleotide sequence ID" value="XM_016906887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QHX4"/>
    <dbReference type="STRING" id="692275.N1QHX4"/>
    <dbReference type="GeneID" id="27904024"/>
    <dbReference type="eggNOG" id="KOG2747">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011815_2_0_1"/>
    <dbReference type="OMA" id="QYQRHGY"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032777">
        <property type="term" value="C:piccolo histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140068">
        <property type="term" value="F:histone crotonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010485">
        <property type="term" value="F:histone H4 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106226">
        <property type="term" value="F:peptide 2-hydroxyisobutyryltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006354">
        <property type="term" value="P:DNA-templated transcription elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016239">
        <property type="term" value="P:positive regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010867">
        <property type="term" value="P:positive regulation of triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000183">
        <property type="term" value="P:rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000022">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.60:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000002">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025995">
        <property type="entry name" value="Tudor-knot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF218">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE ESA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11717">
        <property type="entry name" value="Tudor-knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="11" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 30" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="29">
        <location>
            <begin position="222"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="82"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="28">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="27">
        <location>
            <position position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00045805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00074445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00075313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00076782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00077673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="EMF09584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="516" mass="58660" checksum="DD8F3A9FB853745C" modified="2013-06-26" version="1">MARDDLKSGGNGGDDVKAERGMATLSTLRIGTKAMVEKDGEKRKAEILSMQTRKGHPTFYVHYQDFNKRLDEWVPAERFDLSQEVEWPIPEKAEKSKQKTAQSKSQTTKNENAKNTKVGQKRPRSGTATRDASEAPSDLGAKLSIQRTGGGKENRDPNVAVLTEDVDGTPQPDDESAVDLVDMQEAAAAAKAVPETVPYSREEEIEKLRTGGSMTQNQTEISRVRNLDKLQMGMHEIEPWYFSPYPAEFTDCDMVYICEFCLSYFGSQFQFGRHRKKCQLKHPPGNEIYRDDNVSFFEIDGRRQRTWCRNLCLLSKLFLDHKTLYYDVDPFLFYCMTTRDEHGHHLIGYFSKEKESAEGYNVACILTLPQWQRKGYGALLIQFSYELSKIEAKLGSPEKPLSDLGLLGYRAYWQEVIVDLLLEREAEAGGSGGMASIEDIGMSLAMTTNDVLHTLQNLNMLRYMNKNHVIVLPDSVLAARDARKEKEKIKGKRVIDPERLIWRPPVFTASARTWAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2023-02-22" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>N1QI21</accession>
    <name>N1QI21_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_110062</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758929.1">
        <property type="nucleotide sequence ID" value="XM_016900822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QI21"/>
    <dbReference type="GeneID" id="27897959"/>
    <dbReference type="HOGENOM" id="CLU_1876724_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF10808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="136" mass="15162" checksum="A544E2EF9D62670A" modified="2013-06-26" version="1">MTISGYETYILLVSNLQGAEYPDEEKDETNNPNSSNVALGLYQIKLLYSQSSKNLLKMQGRRPYRLVCIYVHSITPDPTDPVALGLFSDRLPVGEEKGCDPSWVKLRKVVVSSGAWNNLGRNNVHGTTTSYTTDYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1QID4</accession>
    <name>N1QID4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_56846</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765071.1">
        <property type="nucleotide sequence ID" value="XM_016909412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QID4"/>
    <dbReference type="STRING" id="692275.N1QID4"/>
    <dbReference type="GeneID" id="27906549"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064330_0_0_1"/>
    <dbReference type="OMA" id="PFMRETP"/>
    <dbReference type="OrthoDB" id="3647333at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="239"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF16950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="298" mass="32170" checksum="5AE6AA3AE1FD07C5" modified="2013-06-26" version="1">MPVFGPPVDLPPFYSEPTQELISSDPRMRVTEAACIADDADCASASVQDLLDTGTDPRDLQICLSRATQSGHEEVVQMLLSIGVPVSLEAVKVAITKESTRLLSMFLEYGWDINEEEAWCVPPILSFAISMNVSESLIAWFLSNGADPNATCQMDMTPLSDAVALAPYSIVDRMLTHCPPTTVLRGQLLHHAAGRSTPEDCDAILQLVLQRCPPTDINALMYEDHAFSYEVRKIVGLGTPLHGAARLGRLSAIRILIANGADLGLRDSCGNTALEVAERQGHLAVVDELKSLMIATAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>N1QIG1</accession>
    <name>N1QIG1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">arginine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_127112</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(Arg) + L-arginine + ATP = L-arginyl-tRNA(Arg) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
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            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
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    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
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    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956:SF11">
        <property type="entry name" value="ARGININE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arginyl tRNA synthetase N-terminal" evidence="12">
        <location>
            <begin position="45"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="DALR anticodon binding" evidence="11">
        <location>
            <begin position="577"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="268"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF10354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="705" mass="79431" checksum="92D090AA784590A8" modified="2013-06-26" version="1">MALSNGSASQVADIKHITSQLQSVGISELPQPAGVLLHPQRNPVDIYRAVIIDQLHKITGAEPEIVKNAVAWTQDQKHGDLVLPVPALRLKGKKPDELAAEIAEKFDSPLIEKPTVEKTSVRFFFKPEPLAKFVLPAIHQQQGNYGFNPTLGLEDPSQPQSRHKKVIVEYSSPNVAKEFHTGHLRSTIIGGFLVKMFERAGWEAISMNYLGDWGKQYGILSEGFEKYGDENELLKDPVKHLNTVYVKINQDNSAEQKPASILAEKKAELEKLKNPPKPKKQAKSKEAETASAPKWTDEQEQELQRVTAELEKVQQELVNKPSIDEKARRFFKRMVDGDEAALKNWQKFRDESIKAYEGMYSRLNIKFDDYSGESTVKVEDMEKVATVLAEKKISEEDRGAVIVDLSKHGLPTLGKTLVKKSDGTSLYLTRDLAANLERYEKYHFDHMIYVIASQQDVHVKQLFAILKLMGPPYSDVVAKCSNISFGMVKDPKGQTMSTRKGTVISLADSLDSAKEFMHEVMRRNEDKYKQVEEPEATADTLAISAIMVQDYSGKMVNGYNFDLEKMCSFEGDTGPYLQYSHARLCSIKRKAEVSEQEMLAADFSLITAKEGISLIRSLAQWPDVFLNTYKTQEPVTVLTYLFKMSHLLSSCYDAIDRNNKNAKTLSVMYAESREKKMALMAMYEAARIVLNNGMQLLGLTPVERM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1QIN0</accession>
    <name>N1QIN0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SURF4-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_113066</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SURF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="692275.N1QIN0"/>
    <dbReference type="GeneID" id="27898149"/>
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    <dbReference type="OMA" id="RHRHFPW"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Surf4"/>
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        <property type="entry name" value="SURFEIT LOCUS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SURFEIT LOCUS PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02077">
        <property type="entry name" value="SURF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01339">
        <property type="entry name" value="SURF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="10"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF17045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="317" mass="35184" checksum="68E82F883C234320" modified="2013-06-26" version="1">MAQIRGTAGYHLGSGNNANPNHGGGMMNNSFGSGPSSSSATNDPSPLDAIREQTSKLEDLLDTYSDPLKPYLPAIGRFLIVVTFLEDALRIITQWSDQLEYLHTYRYMPWGINHLFLLINVLAMTVSSVLIIARKYSEYAVGGLIGVVVTQALGYGLIFDINFFLRNLSVMGGLIMVLSDSWVRKKFAPAGLPTLDEKDRKMYFQLAGRVLLIFLFIGFVFAGEWSLGRVVVIVIGLVACVMVVVGFKAKWSAIVLVMILSVFNILVNNFWTLHPHHPHKDFAKYDFFQILSIVGGLLLLVNMGPGQVSFDEKKKVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJ39</accession>
    <name>N1QJ39_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_32819</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764428.1">
        <property type="nucleotide sequence ID" value="XM_016908510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJ39"/>
    <dbReference type="GeneID" id="27905647"/>
    <dbReference type="HOGENOM" id="CLU_2948364_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF16307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="55" mass="6426" checksum="CBFBAAE17A7E3C63" modified="2013-06-26" version="1" fragment="single">QRVEYLIDLTKLFAAATAVIRTTKGPTIYLVLVYYNKLFDILEEAIKRLKNKRIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJE6</accession>
    <name>N1QJE6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_145666</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764533.1">
        <property type="nucleotide sequence ID" value="XM_016903188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJE6"/>
    <dbReference type="STRING" id="692275.N1QJE6"/>
    <dbReference type="GeneID" id="27900325"/>
    <dbReference type="eggNOG" id="ENOG502SXHQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071115_0_0_1"/>
    <dbReference type="OMA" id="NDCPASN"/>
    <dbReference type="OrthoDB" id="5358884at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF16412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="31183" checksum="E20D311039FFBA87" modified="2013-06-26" version="1">MDSVQASQRDQARMSLPPQRLSALYQYHNAPEVAPAHGLEYDDTIYPVSDKYPVIRESPLYDGKFSGNGRYHGDGNNRPPRIIFGMKIKTFLVVALAMSLVVVGAAVGGAVGGRQLRDEHQTQLAGTNVTNTALPATGTKITASPTSTFAAPTPTYEPLNDCPASNNTDYTSQYASTTSSSSSSVPAGLAFTKFCDLENPLSMSNDDDDNDNNNDNQDIIAQAFVYSFSDCIEICAAYNYAHSGSNCTVAVYEPSGSRPGNCWIGNTRQRLQPSNLRSSTDGTNVAILQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJI8</accession>
    <name>N1QJI8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_22866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758815.1">
        <property type="nucleotide sequence ID" value="XM_016908364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJI8"/>
    <dbReference type="STRING" id="692275.N1QJI8"/>
    <dbReference type="GeneID" id="27905501"/>
    <dbReference type="eggNOG" id="ENOG502SBR8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107716_0_0_1"/>
    <dbReference type="OMA" id="IKGWQKA"/>
    <dbReference type="OrthoDB" id="8300214at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828:SF50">
        <property type="entry name" value="REDUCTASE (ARC2), PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13400)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="32"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF10694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="145" mass="16613" checksum="933591E55B63474C" modified="2013-06-26" version="1" fragment="single">EQPWHAAFPAPKPEYTAEVMPRNRALTVLSMRIASMLIVDVRRTDYEGGSIRGSLNIPAHGFWWNRGILYELCYKADIEWVVFTCGSSNGRGPRCASWFLEHVRDTVGDQDMNVLVLEGGVKGWVKSGDQYTAYMDGYKEDYWRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-12-14" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJM2</accession>
    <name>N1QJM2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_117957</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760126.1">
        <property type="nucleotide sequence ID" value="XM_016901388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJM2"/>
    <dbReference type="GeneID" id="27898525"/>
    <dbReference type="HOGENOM" id="CLU_2279247_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF12005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="102" mass="11480" checksum="3B3840BC75169DA4" modified="2013-06-26" version="1">MPTLPSHQPTTERFIHLAPPRLLQCDYDGTTTEDGFKMTRLDHSAIPALQPDYCHRNFTIFTRLRPAPRVFFSPAVCPEATEDLTLPSSLLAALTRASWAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-12-14" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJU3</accession>
    <name>N1QJU3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_150798</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">SO2202</strain>
        </source>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF10814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="98" mass="11079" checksum="36DA37CC4CCDDCB7" modified="2013-06-26" version="1" fragment="single">MLARQMAIEMILPAEALRMEFTTQKTTMVPSSIGIVFRQMSRQIFPILKTFVTMRTDVISAFIGLMRSKVMRQVALRTKRSIALAATDLTESHVLFAS</sequence>
</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">SO2202</strain>
        </source>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_016907487.1"/>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_817759_0_0_1"/>
    <dbReference type="OMA" id="DDPEQRC"/>
    <dbReference type="OrthoDB" id="4150019at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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            <end position="134"/>
        </location>
    </feature>
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        <location>
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            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <end position="183"/>
        </location>
    </feature>
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            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
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            <begin position="264"/>
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        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
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        <location>
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        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF16662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="340" mass="37113" checksum="8CBA436A8B952E70" modified="2013-06-26" version="1" fragment="single">MPPDSPQHYGYILSSSRAIGDAVPAFDPYALARPNNATFASGTPQPPGSNRTTQRLPKTKPDTRTLTKSISSPHLRGPIMSESELDKKRNKLGYQRISIACAHCRRRKIRCLLAADDPEQRCQNCIRLKKECVFYPVDQQAMLDARSEASGKPGVPSAPSSAVSTSPLQSGRRGFEHAFTGSYGDPAMPPISAAYQNMPIMPRADQRVPGSYSPQDHSFQAPGQPAPPWATADFAEQHSRKTPISRTPSAQPPFTRYAEAPAADVAPFPGPESPAHPSPSVPQVPCGYNMEQMQQQPHGWQSQSQVTRAVSYSDYPQSYNARYQQAPPPPPPPQPLPSSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKK0</accession>
    <name>N1QKK0_SPHMS</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_117699</name>
    </gene>
    <organism evidence="2 3">
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        <name type="synonym">Septoria musiva</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016901364.1"/>
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    <dbReference type="AlphaFoldDB" id="N1QKK0"/>
    <dbReference type="GeneID" id="27898501"/>
    <dbReference type="HOGENOM" id="CLU_1817017_0_0_1"/>
    <dbReference type="OrthoDB" id="415590at2759"/>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF11726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="142" mass="15559" checksum="E4A3DB1CE398D084" modified="2013-06-26" version="1">MPGVGEAGDNRVSTGTTTAPPSYEVSIDLGQIIKDTGDGMALLRRDFYHVKAHAEVVPHLASSISSLQQEVEDLKAMMDINMKAMCERLKVPFTSCEEVQSSRRREEAAALAGSRWQRRVDYKAQSSAPMWKASRRGSGGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKU6</accession>
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        <recommendedName>
            <fullName evidence="8">DUF803-domain-containing protein</fullName>
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    <organism evidence="6 7">
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        <lineage>
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            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
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    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SO2202</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2012-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genome evolution in poplar pathogens from wild and recently domesticated pathosystems.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Dhillon B."/>
                <person name="Feau N."/>
                <person name="Sakalidis M.L."/>
                <person name="Gill N."/>
                <person name="Aerts A."/>
                <person name="Ohm R."/>
                <person name="LaButti K."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Copeland A."/>
                <person name="Beauseigle S."/>
                <person name="Grigoriev I.V."/>
                <person name="Goodwin S.B."/>
                <person name="Tanguay P."/>
                <person name="Hamelin R.C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765931.1">
        <property type="nucleotide sequence ID" value="XM_016902873.1"/>
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    <dbReference type="AlphaFoldDB" id="N1QKU6"/>
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    <dbReference type="eggNOG" id="KOG2922">
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    <dbReference type="OMA" id="PLCFLIY"/>
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    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="EmrE-like"/>
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    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF86">
        <property type="entry name" value="ADR321CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
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        <location>
            <begin position="53"/>
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        </location>
    </feature>
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            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF17810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="335" mass="36932" checksum="7A5D1888174ECB7C" modified="2013-06-26" version="1" fragment="single">MDPSAALAMGVIVGLASTCVQSVGLTLQRKSHMLEDEKIDESDRRPPFKRRRWQIGMLLFLVANIIGSTIQIVALPLPLLSTLQASGLVFNSILASLLLKEPWTWRTVYGTVLVAAGAVLISYFSAMPEPSHTLQQLLVLLAKPSFLVWFILSLVFVAAVLVMTFCLRYLPGHRRETARISLVNGMAFGLVSGVLSAHALLLAKSAVELVVRSLTHKENQFKTFEPWLLLLAFLFLSLSQLYYLHLGLKLISTSVLYPFVFCIYNIVAILDGLIYFQQMDRLPPLSAGLIALGTVLLLAGVLALSWRLQDDDEDGEHHIVNKAEIPQTLIAPGMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1QLR1</accession>
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        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
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        <name evidence="1" type="ORF">SEPMUDRAFT_134189</name>
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            <taxon>Sphaerulina</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000016931">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF12311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="399" mass="45901" checksum="078CD60C2128AC9D" modified="2013-06-26" version="1">MAASTPNHEPPAVRAISPNANLAKLAAEIHIEIAEMLEDKELRVLRQVCRALAKDTTDVFAKRFFSMMNVSLDIKSLQRFVEMTNISYLAKWMKRIKLRPEPWCRIDGRKTFKRDALTQSFRNLSLLGAGKSIGTSGVWPPASDYKIIGHALADSRHVIDDLKLEWGDWMLGPALFQPIDVERMQVLFQTWAKLRVLRINPLNRFNFETMGGGFHRLFLSAFQITSLYLSMNDIGQVDQFDLRHYPILNEVFSLKHLRQLRLGGVRTNVSYMTDVVLNGRSSLKELVLSRCTIWDGHEPLLWPIVLNHIADELHLTSFQAVHLKGGDDYKGFHQGYFCDCDGSHGFKYEGSKEDIRAKIKQLAETGGHSGMWEIEHKGEDEDWWEVEDEGDDEDWWLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1QLR7</accession>
    <name>N1QLR7_SPHMS</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_122205</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016901754.1"/>
    </dbReference>
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    <dbReference type="STRING" id="692275.N1QLR7"/>
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    <dbReference type="eggNOG" id="ENOG502RYM3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031559_1_2_1"/>
    <dbReference type="OMA" id="CHSEPGC"/>
    <dbReference type="OrthoDB" id="5421784at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021838">
        <property type="entry name" value="DUF3431"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490:SF3">
        <property type="entry name" value="DUF3431 DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF16728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="392" mass="44325" checksum="166CEA9DB5FA0B57" modified="2013-06-26" version="1">MAAWMEQEDKDDGGGGGVGGVGGAGMSTQVFKEPKIDSTSPYPVGKTKPAGSNYTRTLVLPRLKTEDTTWVEQELADMMDSGLLTTAIYTVNLKSGEHKGVLHPPKNKGHEVMVYLSYIIDFYDKLPDVSIFMHAHRYGWHNNELLDTDAAQMIRHLSPERISREGYMNLRCHWDPGCPEWLHPGSTKDNYDKPEEVLLAECWSELFPMDPVPSVLAQACCAQFAVSRDRIRAMPKMKYIGMRDWLIRTDLTDYLSGRVFEHIWQYIFTDAPVHCPSMSACYCDGYGLCFGSPQAFDYYFELKYHKTKLDEELEKWELKAKAIDEAKNVDGSLNEEAPVAVPELGKGKELKSKIESLAAEMQRLRDDALTRGMDPKQRAVESGRKWTEGDGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1QLW4</accession>
    <name>N1QLW4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_112848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764944.1">
        <property type="nucleotide sequence ID" value="XM_016901000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QLW4"/>
    <dbReference type="GeneID" id="27898137"/>
    <dbReference type="HOGENOM" id="CLU_1982958_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF16823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="126" mass="13881" checksum="271AE18E69B5DD3D" modified="2013-06-26" version="1">MPSAKTTVAERLAWQQQFFLYIVGVGFILRAKHATSGRRPERHDCYAVALGQSTSSFGQTRWACGGGIWYYPLEKSCNGSGAQMGATCSSNHAKRLRALRLAYCPQSPAHYDGKASVVLRAFRAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1QLZ0</accession>
    <name>N1QLZ0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Nnf1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_55453</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <sequence length="204" mass="22324" checksum="3ACA21D0AACD4301" modified="2013-06-26" version="1">MINATVGMSSSAVALPRHLFLDRFAASIDRWPLEGLGGFCRGHTVVQLRSSDFPGTDGNILLPSTIDWPTCDIRLPTTVLRQKKQLRSISHKQDSDRASDPQSSLAMTATAAAIPREVRDETTNTEDTSAGKQLFKKATTGMMKGGREVALGTSRLGSLRKRSVQTQGPSRPSSRLSMFVERLNVGTGSQGREPQRCSMDFWET</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
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                <person name="Zhong S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">SO2202</strain>
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        <source>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
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                <person name="Lindquist E.A."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">SO2202</strain>
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            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
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    <comment type="pathway">
        <text evidence="3">Lipid metabolism; sphingolipid metabolism.</text>
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    <comment type="pathway">
        <text evidence="4">Sphingolipid metabolism.</text>
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        <subcellularLocation>
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            <topology evidence="2">Single-pass membrane protein</topology>
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        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008117">
        <property type="term" value="F:sphinganine-1-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030149">
        <property type="term" value="P:sphingolipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000020">
        <property type="entry name" value="sphingosine-1-phosphate lyase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.140.2150:FF:000001">
        <property type="entry name" value="Sphingosine-1-phosphate lyase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050477">
        <property type="entry name" value="GrpII_AminoAcid_Decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735:SF6">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE LYASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 17 18" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16 17" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="16">
        <location>
            <position position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMF17198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="561" mass="60911" checksum="D75193EE17FD4AC0" modified="2013-06-26" version="1">MALLSPQLRKHYHPRTPQGRQALLAQGIDLVRNILFALFVLRLTRKTLLQLRGYGLLGCIQSLYTTIYRRLYALFLRLPFVQAKVQADVKKAIAELQSKLVPSGPGVVNYTTLPAQGWTSAQVRAELERLGDMEHTRWEDGRVSGAVYHGGSELAELQSDAFKRFGVSNPIHPDVFPGVRKMEAEVVAMTLGLFNSPDTAAGVTTSGGTESILMAVLAARQKAYHERGITEPEMILPNTAHTAFRKAGEYFKIRIHLAACPEPSYKVHTRSVSRLINSNTILLVGSAPNFPHGIVDDIPALSRLAIKHKLPLHVDCCLGSFVIAFLSKAGFPSPDFDFRVPGVTSISVDTHKYGFAPKGNSVVLYRTADLRRYQYYICPDWSGGVYASPNMAGSRPGALIAGCWASLMNTGEDGYVHTALQIVSAAKQIEDAIRTKSSLKHSIAVIGKPMVSVVAFRALNNSKTPNLAVDIYDIADAMSAKGWHLNALQDPPAIHVAVTIPIVSAVDALIQDLEIVVESCKGHVTANKGDTAALYGVAGSIPDKSIVKDLATGFLDTLFHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1QMM3</accession>
    <name>N1QMM3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_160138</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764845.1">
        <property type="nucleotide sequence ID" value="XM_016907882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QMM3"/>
    <dbReference type="GeneID" id="27905019"/>
    <dbReference type="eggNOG" id="ENOG502QRB5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034574_1_0_1"/>
    <dbReference type="OMA" id="MNWAFVI"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052413">
        <property type="entry name" value="SUR7_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G07470)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="197"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="245"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF16724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="369" mass="39832" checksum="38FB5E6C6153ADB3" modified="2013-06-26" version="1">MGKAGRVACIFIPMALTIASFICAILLQVAGWNTLDSYHFFKANLTDLHADGSASTNTALTTAIGNIKTAGGIGDIYEIHLWNYCWSNQTDGSDKDCTSRKSGFVFDPINIWGLETDDTTATSTSSSDNALESAVANIKDNYDEYADKLLGSSGKKALSAYRKVAKWMFIAYQVAFWTNLATIVIGLLAICSRWGSLLTWILSFVSTLFTFASVLTSTVLFAVLVRALNEVLEDYGIVLTQGRNALIAGWVGVAFSLAATFFWVFSICCCSGRSNPHHKSNKGGLWNAEPKGMGYRNDDAFSVNRGGREGVKAEKTGGDYTRVASPYVGDYENNDQLPLHDYAQPSPHVGGGAGGGGGLHQGYEPYRHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1QMR0</accession>
    <name>N1QMR0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7905 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_76362</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764920.1">
        <property type="nucleotide sequence ID" value="XM_016910137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QMR0"/>
    <dbReference type="STRING" id="692275.N1QMR0"/>
    <dbReference type="GeneID" id="27907274"/>
    <dbReference type="eggNOG" id="ENOG502S50B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_393876_0_0_1"/>
    <dbReference type="OMA" id="WDNMLGQ"/>
    <dbReference type="OrthoDB" id="4739136at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057227">
        <property type="entry name" value="DUF7905"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25482">
        <property type="entry name" value="DUF7905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7905" evidence="2">
        <location>
            <begin position="343"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="680"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF16799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="700" mass="78668" checksum="1AEBD40AFB830ED1" modified="2013-06-26" version="1">MENYEGENKDGWDADLDGDPELVRAGESTWTQVDHKKLPLLKKKQAAPILPPSAQHHPRPPFPVQRLWRGSRGQPLGDSKRPKARKFEADPDNAGKKAWRARQPYKDTVVVPLAIAGAIRDNLAGLALDQGCFLACVDGVGLGLWGTSSDVSEAKRRILSAIGNDRSQKNSSFRKLGSLTPKLRQRAETRFRNDVKRNCYRQIPLPEELFDAIGTFHWPHLEYRPEDVLGPSYEALDPVRMDCECYINYHSDIHSFLVLGGSKQVQAALLRIRRTCFQLTAQSINPVRLALTHWRASIVPSLVSLEPYYGPNTITASIEDVKDVDYSPRGEVAVTDASALEDATKRSILNVERARMTLENALKKIHFYIGTITLVIRLGTFVLRQWAPPEAGVYELEEYEDMTKESQFRGEVTEELGNVDDHVLPLVQAANKLLVPQDVMTATLADVRPKFSAVFSFEDGAGDLLLIKSWHEEEGSEASVDQLVEGKDRWVRVDRDTGKATHLATIALTDLHTGSAWQFDITATRAVDEAKIEHAYTDFSKGVKIKPDVALGSANERFVNWKSVVPVKSLRQEVQYRYNIAQTDYTLDLVRFQDSKFPAGQSTIRKLPPEVSKSCWGLSVSRAEWATMFSKNERLPIGTYADWPDDMATWFPPDFACDSESSDGFLQLVNKLEQIDKLFHPKRENGKQGQSDLPEVVNQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNC9</accession>
    <name>N1QNC9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_146270</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765290.1">
        <property type="nucleotide sequence ID" value="XM_016903543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNC9"/>
    <dbReference type="STRING" id="692275.N1QNC9"/>
    <dbReference type="GeneID" id="27900680"/>
    <dbReference type="eggNOG" id="ENOG502SJAK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1166466_0_0_1"/>
    <dbReference type="OMA" id="DCTYLIF"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF17169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="238" mass="26011" checksum="E0138A3D71AA3833" modified="2013-06-26" version="1">MKAVAPDYTVVAAATPFLGLGGSVIAGGFSLMSKEYGCISDPENMLDVEVVKLDGSLVWASSEPDLLWAHRGAYIGLGVVTRIKLRAYKYPQDIWGGSIIIPRTKESEVAQAISAMDHSKAVENRVFALLIPMPQVFIVNAFDANGEEQGRQTFGPILQIEGAMDMTKTMDLAGFAQMQAQAEAQKGHLHQWFNPLALGKLSEELVLKSFDWQRQCAAQGTQATVMYELWGTVSNFSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNH0</accession>
    <name>N1QNH0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Intermediate filament protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_35049</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765400.1">
        <property type="nucleotide sequence ID" value="XM_016908592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNH0"/>
    <dbReference type="STRING" id="692275.N1QNH0"/>
    <dbReference type="GeneID" id="27905729"/>
    <dbReference type="eggNOG" id="KOG2101">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002131_1_0_1"/>
    <dbReference type="OMA" id="AMYVVEV"/>
    <dbReference type="OrthoDB" id="120967at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06876">
        <property type="entry name" value="PX_MDM1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013937">
        <property type="entry name" value="Sorting_nexin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF3">
        <property type="entry name" value="SORTING NEXIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08628">
        <property type="entry name" value="Nexin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00313">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51207">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="PXA" evidence="7">
        <location>
            <begin position="103"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="5">
        <location>
            <begin position="421"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="6">
        <location>
            <begin position="882"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="571"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="717"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="839"/>
            <end position="873"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF17279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1241" mass="137886" checksum="77DC753270C1B4E4" modified="2013-06-26" version="1">MPVERRHAIAAAIVAFISWAYLTDWLPQLRFVPHAFVGGVLAAALGAVYVVATTVQPRARWAGAPRRGLPTTLAFAQPAVWAEEKTALKGREEYRRPIIFPEAEKFSKHIDGLLDLVLRDFVTSWYGHISQRPLFQNEIDRCIRSVLLSVAARLTDLDLVEFAIASMLPVVTNHMRDFYDAERAVRGKALENHVTESEELNMAIAGKYKAGKLHPVAALAHADGTLAAQTHMRRLLEKILPSVLPTNMKSSAAVMALIREIVACAVLGPIISMLADPDFWNQQIVSVGGAMLQDRKSVRKVRAALDQHAPASPGKTSRGSQFPRLRPYDSERQFERFIRSIRHVSTLNDARLFRSQVSLQLRRDAQIEGQDIAYIRRLETGRRLLDQKIASLSATDDGNAAQSVPTTTRNTETVSRKRFASLREVIYDAAGLSYFMEYMDRQHLMRLVQFYLVVDSFRNPLEGDNDEAPASLAADPEKMDIAQMYTEYLSKPELETPAETMQVVKQCLKAGSKASVRDYIAARREVLRMQSKVYSTMKEKHYEAFKRTDLYYKWLAIDDAPKFGPALSGESDLLSSQPTGTPLFDDGQPSHIRRPQLVLPPKEPELRRAVLSTSDLKTVGRSSSMFSDISRRSLDDANENGRRALFGGEGTSTLFGDSIDNEKMTQSVTSLKGYDSDEETARHAQEEAKAVREMQAALDNIVSDDHDQASLFADAAGRRSLDEEDGRSSIDMPNRPGLPTSASQTLDRGKPSLSSLGLVGGPSSRGVFVDDLFGHEQEKFAEDEREDSNGPSDIDEDKIEEAAAGDLGLAEAIDVLNADIERLSAQRNVLDSLSAKAELTNNQAELRILRKSEQSLQREIRRKEMQKQQYIVQESDNGLYGRALVSIKSVMVGKEDDGHEYALYVIEIRRQAGEQMPAATWAVTRRYSQFHELHKRLKARFPAVRELEFPRRQTLFTLQKDFLQKRRATLEKYLRSLLLAPAICRSRELRAFLSQSAIATNGGNGTQADAKDFVTRIYNSVSDGMEEFLGNIPVLDQLSVAGQNLISAATSQINGASPVDGIDPAVQDPATSTEAEAELNAYETKEVEPFVKPICDLFLETFELSKGNSWLRGRTVVVVLHQLLGGTIERKVKEAAASALEDEKLASYVDTLKRTVWPDGKMRPPSVPRTVAEKARTRKEAGILLGALVPDLAGSVVGKTNAQAASRKVVAMLNNPRLNLHMVFTLIDEVVGKIFPEALDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNQ9</accession>
    <name>N1QNQ9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_146871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016766104.1">
        <property type="nucleotide sequence ID" value="XM_016903924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNQ9"/>
    <dbReference type="STRING" id="692275.N1QNQ9"/>
    <dbReference type="ESTHER" id="sphms-n1qnq9">
        <property type="family name" value="Canar_LipB"/>
    </dbReference>
    <dbReference type="GeneID" id="27901061"/>
    <dbReference type="eggNOG" id="ENOG502QSW8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029537_0_1_1"/>
    <dbReference type="OMA" id="FMAVSGD"/>
    <dbReference type="OrthoDB" id="4605274at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053228">
        <property type="entry name" value="Stereospecific_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37574">
        <property type="entry name" value="LIPASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37574:SF1">
        <property type="entry name" value="LIPASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110493" evidence="1">
        <location>
            <begin position="23"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF17983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="473" mass="50065" checksum="E90E17E226FCC17C" modified="2013-06-26" version="1">MANMRTSLVLGLLGALLHQTQAVPTSTVKEVELEARQNNPLGLVVANIENLLNETVTNPPTNNLFGRIEDSLKAVTSTAVPVSLPAAFNDLQNILVGGAKPSNIYGYVASLVSAGLSKDNIPDLLNFVKGVGSSAQANGENSFNNVNPIQPATNIYPKANPQDAPYSLSEESLRAAIHIPSSFQYGRSGAPNPIILTPGTGATGYLTFIGNMIPLLQGSSIADPVWLNIPGYLLGDVQQNAEYVAYAVNYISGISGNRNVSVAGWSQGSLDGQWAWKYWPSARRLVTDFITFSGDFAGSIFGTFLATPGIPLPPAYVQQAAGSNFINTLRSNGGDSAYVPTTSIYSSFFDEIVQPQTGTAASAFIRDARNVGVSNTEVQQVCSGAPAGSLYTHEGVMYNPLSFALLQDALAHPGPGQVSRIPNLQQLCENFLAPGLGLTDFLLTENSIVAAVLTTVTYPQKVIVEPPIKAYAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M3ARG1</accession>
    <name>M3ARG1_SPHMS</name>
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        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_152363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF08069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756190.1">
        <property type="nucleotide sequence ID" value="XM_016907400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3ARG1"/>
    <dbReference type="GeneID" id="27904537"/>
    <dbReference type="eggNOG" id="ENOG502SKDE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_600154_0_0_1"/>
    <dbReference type="OMA" id="FDIVWRF"/>
    <dbReference type="OrthoDB" id="3535998at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37012">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37012:SF7">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF08069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="456" mass="51708" checksum="9D845A095C345EA8" modified="2013-05-01" version="1">MRRNSNASNSCRIERKRAHDREAQRASRAKTKQYIAHLEKTIADLTEGSGDNHANYLAQHASQQSQEIDKLQGLVNKIRTLVQDTVKSEEDGLPEGNALSPSKTFSVMNWDAQSEDRCLMNDVTQPQSSNFKQAQEPRQAASSPRSLVVLGVDLYCEDSDEATYLLRLNELIEKLEKTPDNLSSLEEDQDILIRAITCGWDASERLHHFDIVWRFLRAFDEGLWHRAQPIERFAHFWNVRSTMLHKIQLKNQPRRKMATFMSTTVGQRSSSYPAIIDYFGWPQVRKHLLTTGLKQCTDRGVLAFTESFRFVWPWELRDAYKINKTTGMYSFSEAFLKSFNDISSFRLLANELVPFEVRPPSQTVPESNFADADEGDTSADDEFSHPEPTFGAAAAVAASEGEQVMHTEPSAQDWMATLASLHEAGRHEIQSVHALPIAPETSLALWGNTREPVGFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M3AS46</accession>
    <name>M3AS46_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Only prolin and serin are matching in the corresponding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_152023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756455.1">
        <property type="nucleotide sequence ID" value="XM_016907195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AS46"/>
    <dbReference type="GeneID" id="27904332"/>
    <dbReference type="eggNOG" id="ENOG502SJFJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020684_0_0_1"/>
    <dbReference type="OMA" id="KIPRLHD"/>
    <dbReference type="OrthoDB" id="3882058at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF08334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="523" mass="57630" checksum="FDE7C13B98A48439" modified="2013-05-01" version="1">MSRLRSFSFPRIASSPLPEDDMAPPSSPSHSRDSSGESSNSSPLTPTFSTRGHTRFPSSTSSLATNPDSPANPQKTTLHDLVEDPSELDDQNDASEDATPEALCICDTPLCYHRQREGSPDFPAPLVTPEWSPGDDYFDDGYLPGARAIKRPRSNDNLADSFASRLSRQFSRRFGGHRPSASSSTIKLRSAPSSRPSSLRLPATRSSTAPNAHEVRNVSMPPLGALRAPIHERSISPPRPRAVSQVTSKPMDISIPEVQEDSVERQELATTPLLPPMLVSYFADSQQALPSPLTSPTVAPPSVVPSMVSTPVSSPIAHGFPTPPLSTKASTASLNMRSSHTLPTASEIPALNIAEETDYWAIKLGHANFNIYPEPYLPELCDVQHCRQLRDDWETARVEYMRQAARVSENYGVTSQIYKLTEQKWAEIDSIWRYNHELANAEAQASGEETVFQPLAETQTLKKMPSLQDPKQPSKFPVIEEADIVGPMVQYAKIQHRRQPSKKSSFLKIFTDFARPNLGLQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>M3AUQ8</accession>
    <name>M3AUQ8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_150944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF09811.1"/>
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        <property type="nucleotide sequence ID" value="XM_016906491.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="27903628"/>
    <dbReference type="HOGENOM" id="CLU_1628107_0_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="163" mass="18439" checksum="E02C292B69DF2B4B" modified="2013-05-01" version="1">MLEKSTRVHKELAKMRDRPTIQRKNSVMDKHPEPIFDDHLVSKRHAAGSWQMSPERNLKELRSIEATKPDGESPLAGDSNVKRVWCVTPVLRCNRSSWLTTPKSGTPQAISISSPTSRNRYELPQFPSPTSRHPIRQESTNDSHRLRSTSHTPATPASVTPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M3AX18</accession>
    <name>M3AX18_SPHMS</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_150249</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016906046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AX18"/>
    <dbReference type="STRING" id="692275.M3AX18"/>
    <dbReference type="GeneID" id="27903183"/>
    <dbReference type="eggNOG" id="ENOG502S4R7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030267_0_0_1"/>
    <dbReference type="OMA" id="AHEDWDY"/>
    <dbReference type="OrthoDB" id="2157498at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029164">
        <property type="entry name" value="PIG-Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39400:SF1">
        <property type="entry name" value="PIG-P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39400">
        <property type="entry name" value="YALI0E29227P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15159">
        <property type="entry name" value="PIG-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="363"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="411"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="333"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
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        <location>
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            <end position="62"/>
        </location>
    </feature>
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            <end position="106"/>
        </location>
    </feature>
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        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF11275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="447" mass="49558" checksum="B59346AADDF1F278" modified="2013-05-01" version="1">MPEPRRGSGDRRRITVSGPLPNLDDGGDDDGDNVQKPSRDSMKFSRSSPSTPSLPVEQTTAAASPAKRTEHRRSVSTHLLAKLNFLNRLSEDDRPPSREKESEVKPPKSPRSSKSRKSIDDDEPVTSPVSPAKGDGAMAAVLKATKSRKRKGSLRKTALLGTRRLVTETRERRNSVLQRTPSLKLAQQVQAARTDDYGGEPKRPPLPSRDSSSTTLRKNFSYENVNAASSNDRVWPEPAAVTTARLSLLTDHRSQLEQRKDVTELKSPLDLKSSISNASYASTTDDDDMLTFGRSANSYIAQQKPLSSTTSSYFPEASISRRPSHQSRKHSRSPLSQNLTSALSTFPASPLALEPHDYTETEYWGWVILVVTWLIFTVGMGSCLEIWSWAWDVGETPYAPPELEDDPTLPIVGYYPALIVLTGVVAWAWITVAWVGMKYFRHAKIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M3AX54</accession>
    <name>M3AX54_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7907 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_134474</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016902646.1"/>
    </dbReference>
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    <dbReference type="STRING" id="692275.M3AX54"/>
    <dbReference type="GeneID" id="27899783"/>
    <dbReference type="eggNOG" id="ENOG502STWI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081634_0_0_1"/>
    <dbReference type="OMA" id="RWYACET"/>
    <dbReference type="OrthoDB" id="3515453at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057229">
        <property type="entry name" value="DUF7907"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25484">
        <property type="entry name" value="DUF7907"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004031530" description="DUF7907 domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7907" evidence="2">
        <location>
            <begin position="26"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF11300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="207" mass="22514" checksum="D95CACE64F4BB8C9" modified="2013-05-01" version="1">MKSIIAGVAALLFLTSTVAAQNYTQSKPFNLILRSSNSTLNGKGLTPCHEGAAIEGLCVSNAPGQAYQWNTTDGQVVSNKNLGKSGILTFELKGGNFVASQPMHLVFNAATNIAHAQFAPVAPSEAAQVGFDRKHKMFIPAYYDDTVVPAKVNKEFGLYHWYICQYNYSGYNYSSLNFVVGNAQPQNPTCQKVDVVRTAIRTGYYKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M3AXG4</accession>
    <name>M3AXG4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 17</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 17</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED17</name>
        <name evidence="10" type="ORF">SEPMUDRAFT_69041</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 17 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759551.1">
        <property type="nucleotide sequence ID" value="XM_016909850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AXG4"/>
    <dbReference type="STRING" id="692275.M3AXG4"/>
    <dbReference type="GeneID" id="27906987"/>
    <dbReference type="eggNOG" id="ENOG502QS9H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015164_1_0_1"/>
    <dbReference type="OMA" id="AAETKYW"/>
    <dbReference type="OrthoDB" id="5319830at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019313">
        <property type="entry name" value="Mediator_Med17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13114">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13114:SF7">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10156">
        <property type="entry name" value="Med17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF11430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="604" mass="66294" checksum="9690BBD61A50C122" modified="2013-05-01" version="1">MPEGGASFRPWSSTEQGTASLGETLAQIQAERGHFRNITEEGLRAEIAAEENGQASQSASGDEEDSGQDGDARDGRRQPTTRQELYAIREELTRRAQEAHQDVLVTLDMVSLLQTTYTPAQAATTVSPAAKAIVPLSSLGADLWARTPTDPARDAQDSLIATNVRAKYLSESADSLLSAASRLEDNVRKETQYWDQVLDISAKGWNVSRIPGQKQRLLGVHFGLSGSASDSTSRNIAALIPDDEGNIKLERGVGSRPKAVRAIVKRGSQIVGSSKLPVLLDTSETTLQARIRHARDSIFDEELFREMVRETRTLLARGVTMRGSTIVFEVSETESPECVELELVSLDEDNSLPFECSRESDHLAQATLLAARLLLNRAHREKIKKKSLLPPPMMPAENKLQPLLILRPILTMLQHSSHVLQINAYLDTLNQLLTRVGLPTTINTARVALPMTPRGVVDTESFLDTLLQPLSAEASIGIDSFPPFKLATGTSLQDDVGFTFAIIRDGRSYPWDCVADLVEETNQWLPDTIHRFISLKTEHWMFQQSSGHLVSKTDGAHRSAFVDLDGSAGTIELKMGKEKASWSLNGDSAEQGSIVDALLKWTKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M3AY02</accession>
    <name>M3AY02_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription factor TFIIIC triple barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_65377</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760493.1">
        <property type="nucleotide sequence ID" value="XM_016909717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AY02"/>
    <dbReference type="STRING" id="692275.M3AY02"/>
    <dbReference type="GeneID" id="27906854"/>
    <dbReference type="eggNOG" id="ENOG502SV1F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_769708_0_0_1"/>
    <dbReference type="OMA" id="TTHVPNA"/>
    <dbReference type="OrthoDB" id="1877767at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019481">
        <property type="entry name" value="TFIIIC_triple_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10419">
        <property type="entry name" value="TFIIIC_sub6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor TFIIIC triple barrel" evidence="2">
        <location>
            <begin position="20"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF12372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="384" mass="41920" checksum="6E04AB1529EAEF12" modified="2013-05-01" version="1">MGQAAVVHDSEWEYEYDASETEHFYFTLDLTTHVPDALVRKYDTAADSHANIDAAPKSSSGDGLQNEDVTTTATTTTGESLPNVAEARSRPRTTLQILDLHTKNPLVKFDHAIYSCYWSTDLGTQFHISQAGLTPNPRRAGTVLDVIGLSQTRLIGKPVNLTQKGFRADEEANSAAPDEHDTVESSGGQVDVDADADADAAAAIERAKPAASSLKSATQQPLVIPRELCKNLAAETHASFLERLSEIKLKKGETDPVPIFSIKYHREPDNKDELKKRAQAADAAKQKDDEEAVSGERARKRRKRLTAAEKGTRPTDAPSTCGRHGREAIGARVGFEGQAPGALWTKKKQTRRKPAEARESSDEHLSDNLEMEVDDPDADYAPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M3AY13</accession>
    <name>M3AY13_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutamyl-tRNA amidotransferase subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_163540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760503.1">
        <property type="nucleotide sequence ID" value="XM_016908064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AY13"/>
    <dbReference type="STRING" id="692275.M3AY13"/>
    <dbReference type="GeneID" id="27905201"/>
    <dbReference type="eggNOG" id="KOG1211">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_14_1_1"/>
    <dbReference type="OMA" id="HANDSWA"/>
    <dbReference type="OrthoDB" id="566138at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678:SF34">
        <property type="entry name" value="OS04G0183300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004031906" evidence="1">
        <location>
            <begin position="21"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="56"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF12382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="556" mass="60257" checksum="FEB349D8E02A0079" modified="2013-05-01" version="1">MTKFQVKAIVLLGGLQTCCSQWTPSTSNLATFPSLLDVELDDLVMGMEKEMFTSVDLVRAYTARILEVNSTLHMVTELNPDALAIASSLDAQRKNGTVLGPLHGVPILIKNNIATADQMNNTAGSWSLLGAKVPQDSTMAAKLRKAGAVILGKTNLSQWANYRSDNTSNGWSAHGGQTYAAYYPQQDPSGSSSGSGVASSVGLALASLGSETSGSILSPSDVNNLVGIKPTVGLTSRYLVIPISEHQDTVGPMARTVKDAAHVLQAIAGPDPKDNYSSAYPFETMPDYVAACQTSSFEGARIGVAWNVLDIWGRYTDKPVLDAFMEAVQQIEAAGATIVTANFTGFAAWQNDSVGDTVLSADFEVGLAQYLSQLSYNPHNITSLADERNWTQTHSIEDWPERDTGIWDTFLLNQTWNNTDPRFWEAYQKNLYYGGEGGILGALNRTNTTAVLLPTQLSPSIPALVGSPVVTVPMGFYPYDWNVTMNGFGNLVASGPNIPFGLSFLGEKWSEETLIGYAYAYEQRTLHRSKVQPYIRPNIELKDVVVVDQGPQHYEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M3AYB6</accession>
    <name>M3AYB6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">mRNA splicing factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_149156</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760623.1">
        <property type="nucleotide sequence ID" value="XM_016905377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AYB6"/>
    <dbReference type="STRING" id="692275.M3AYB6"/>
    <dbReference type="GeneID" id="27902514"/>
    <dbReference type="eggNOG" id="KOG0495">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007010_0_0_1"/>
    <dbReference type="OMA" id="DGWAWYY"/>
    <dbReference type="OrthoDB" id="440128at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001164">
        <property type="entry name" value="mRNA splicing factor (Prp1/Zer1), putative (AFU_orthologue AFUA_2G06070)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000256">
        <property type="entry name" value="Probable pre-mRNA splicing factor prp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010491">
        <property type="entry name" value="PRP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06424">
        <property type="entry name" value="PRP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13428">
        <property type="entry name" value="TPR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="PRP1 splicing factor N-terminal" evidence="9">
        <location>
            <begin position="12"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="849"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="119"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF12502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="946" mass="106348" checksum="17624DAFFB47622F" modified="2013-05-01" version="1">MSGRKDFLSQAAPENYVAGLGRGATGFTTRSDLGPAREGPSEEQIKAALAKRAADAGIDPSSAYKLDKKQDDAEDEERYRDAENEEGLFASGNYDREDDEADRIYQDVDDRMQKRRKISREDRERREREEYEAKNPKISQQFADLKRALGTVSDEEWHEIPEVGDLTGKNRRSKQNLKQRFYAVPDSVLAGQRDAGQLGSEIQDDGMATEADGSGGSSEQVDGTMTNFADIGAARDKVLKARLDKAAGAETSFASGTSTTVDPRGYMTALTNSQLKAGEIPVGDIRRARILLESVIKTNPRHGPGWIAAARLEEYAGKIVAARNVIRRGCEMCPKSEDVWLESIRLNDNANAKIIAAKAIENNDRSVRLWLEASSLEAVPAAKKRVLRKALDHIPQSVAIWKQAVNLEEDPADAKLLLAKATEIIPLSTELWLALARLETPEQAQVVLNKARKAVPASFEIWIAAARLQEQTGQEAMVYKVMERAIKALQRESAMLKREQWIEQAEVCEEEGAPLTCRAIIKETIAWSLDADDDRKQIWLDDAKSSTNRGRYETARAIYAITRKEFYNRKSVWIAAADLERTHGTKEQLWAILEESVKSIPNSSELWMQLAREKWLAGDVEGARRVLGEAFSKNPENEDIYLAAVKLEADNGQEDRARLLLAQARQEARTDRVFVRSAAFERQTGNSDRALELVIEGLDAFPKNDKLWMLKGQIYEAKGNLPQAREAYRNGADRCPKSVPLWLLWSRLEEKMGVVVKARSVLDRARKQIPANPQIWTESVRLEIRAAKRANNSANTSTSNPAASQKMAQALQECPKSGLLWAERIWNLEARTQRKPRILEAIQKVENDPILFVTAARIFWSERKLDKADTWFKKAVTLDPDYGDSWAWWYKFLLQHGTEEKVRQVVESCVENEPKHGEKWAAIRKAPENGGKTTEEVLKMVAKALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M3AZS5</accession>
    <name>M3AZS5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Complex III subunit 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_149526</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The complex plays an important role in the uptake of multiple carbon sources present in different host niches.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the UQCR10/QCR9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF13022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761143.1">
        <property type="nucleotide sequence ID" value="XM_016905609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AZS5"/>
    <dbReference type="STRING" id="692275.M3AZS5"/>
    <dbReference type="GeneID" id="27902746"/>
    <dbReference type="eggNOG" id="KOG3494">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_171977_3_0_1"/>
    <dbReference type="OMA" id="IKHKYEV"/>
    <dbReference type="OrthoDB" id="44067at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.260:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.260">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008027">
        <property type="entry name" value="QCR9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036656">
        <property type="entry name" value="QCR9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12980:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12980">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX, SUBUNIT X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05365">
        <property type="entry name" value="UCR_UQCRX_QCR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81514">
        <property type="entry name" value="Subunit X (non-heme 7 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF13022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="66" mass="7381" checksum="258B0622A254A04E" modified="2013-05-01" version="1">MSGLLGTVYNALVKRNAVFLTTIFAGTFAANIAFDVSANKIWDQVNKGRQWKDIKHKYMDAGDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M3AZU5</accession>
    <name>M3AZU5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">M protein, serotype 2.1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_149546</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF13047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761168.1">
        <property type="nucleotide sequence ID" value="XM_016905622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AZU5"/>
    <dbReference type="STRING" id="692275.M3AZU5"/>
    <dbReference type="GeneID" id="27902759"/>
    <dbReference type="eggNOG" id="ENOG502QVZ5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015321_0_0_1"/>
    <dbReference type="OMA" id="METIYEA"/>
    <dbReference type="OrthoDB" id="2121319at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06503">
        <property type="entry name" value="ATP-synt_Fo_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38120">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38120:SF1">
        <property type="entry name" value="M PROTEIN, SEROTYPE 2.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="206"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="417"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="262"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="428"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="502"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="540"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="554"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="568"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="579"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="615"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="676"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF13047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="712" mass="76936" checksum="F560DF61E161190C" modified="2013-05-01" version="1">MSTPNSKKPPIPAAARRTPTTAANNPPASTHNNQGSQSPSRMISSSTTSSNGPGATVGLNRSRSTRTGAAPVSARAAVRGKPVADSAADEDAKAELAARMDELQEKLQEAERACEESQKQAAVLQVKLDEAHKEQGMLEETVHEHTERINDLELEKKESVRARREMEQIYESEKEAAMKEKEEAATREVEMQAALQRMKETLAQREMRAGLEDDSRRPMMTRHSSNGRSANGSPVRDASDRQFAPPSVSRSDSASRINSKLVNQKDKIIEGLRLELAEAQIKLVEMENMGGGRLQEIQRQLYDVKMHNARLMEENESFQLLLSEKTLQGDFLRAPSHPGSRPPSRHLDTAVGTSLADELDSQVDESEIEGDTRRLQAEVQSLKDANKALTLYINNIISRLLQHDQFEAILDKTPDLMAGPGAASTKRQHADTDKELPPPPPDKDEQPSLLQRAKSVMGGTRPRPRPLSQSLAPGDQLEPSLKTPGLNEDPKTAPSVPIARSRSTRASHGHRRANSDWPAASVVTNMYRGPSPNAGPLSPGLTSPINRNSFFGRTPSSSTSVPTISEDNIDKESARDSKMSGSASNRNSVTSNPTYAGIDDDSSTGAASGLLNERSNPSSPPQSTTSSGDRDKPSGAIMMGSKPRPLRLVQEAADEDAAKKQANRGSWFGWMNKGGAPPPGSLQSPPAPSSQGLGEKLGGVFRKTDAEASQAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M3B0B2</accession>
    <name>M3B0B2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Polyadenylation factor subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_148595</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for 3'-end cleavage and polyadenylation of pre-mRNAs. Also involved in chromosome segregation where it has a role in chromosome attachment to the mitotic spindle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761348.1">
        <property type="nucleotide sequence ID" value="XM_016905019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B0B2"/>
    <dbReference type="STRING" id="692275.M3B0B2"/>
    <dbReference type="GeneID" id="27902156"/>
    <dbReference type="eggNOG" id="KOG0284">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_77_1_1"/>
    <dbReference type="OMA" id="YGSSMVQ"/>
    <dbReference type="OrthoDB" id="16717at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180010">
        <property type="term" value="P:co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001039">
        <property type="entry name" value="Polyadenylation factor subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:002008">
        <property type="entry name" value="Polyadenylation factor subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045245">
        <property type="entry name" value="Pfs2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836:SF0">
        <property type="entry name" value="PRE-MRNA 3' END PROCESSING PROTEIN WDR33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="84"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="126"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="167"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="209"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="251"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="364"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="394"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="492"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="519"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="417"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="432"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="447"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="524"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF13227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="600" mass="65811" checksum="A7CEF0F79972BE3F" modified="2013-05-01" version="1">MDRDFDHGGLDQPRPRGRPSRRNATDIGNTYVHYMHDRRSKNSSVRGFEVERPSLSYAASMIPPAARKAKAVDSLPAKHLHSSFNKHRHPVNVVKWTPDGRRLLTGATSGEFTLWNGTGFNFETIMQAHEAAVRSIVYSHSDDWLISADQEGLVKYWQPNFNNVKEIQAHDMPVRDMAFAPQDSKFVTASDDAFLKIFDFATGEEISKLDGHQWDVKAVDWHPSKGLLVSGSKDHNLKLWDPRSGRCLTTLHGHKNTVNMTKFEPSRGTLLASCARDQTVRVFDINMMRDVFLLKGNEKEINSIVWHPIHSSMLSTGAADGAMSHYLLDEQNPPPGTQITTSPYDAPNPADAPAQTLYPSHKVAFAHEFNVWSMDWHPMGHILASGSNDRATRFWTRPRPGEGSFINDKWHIGQSAAEEKGTWKRNERQAREEEDAEEQDEADGLEDQQMPSRSALPGLPGLPGLGSAIPAPSPENGVFGGAPSNLPIHGLGNGLQFLPPPPPGSLPPGMDMAAFQKALSSGQLPPPPPGMLPPGFVPPPGFPTGYPPPPPNGFPGMPPSTDSPANGGSGSAGSRRRAPLPDQADALKQEMMQGRYLKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M3B2H4</accession>
    <name>M3B2H4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C-1-tetrahydrofolate synthase, cytoplasmic</fullName>
            <ecNumber evidence="8">1.5.1.5</ecNumber>
            <ecNumber evidence="7">3.5.4.9</ecNumber>
            <ecNumber evidence="6">6.3.4.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">SEPMUDRAFT_147837</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>(6S)-5,6,7,8-tetrahydrofolate + formate + ATP = (6R)-10-formyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20221"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.5" evidence="8"/>
    <dbReference type="EC" id="3.5.4.9" evidence="7"/>
    <dbReference type="EC" id="6.3.4.3" evidence="6"/>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF13957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762078.1">
        <property type="nucleotide sequence ID" value="XM_016904546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B2H4"/>
    <dbReference type="STRING" id="692275.M3B2H4"/>
    <dbReference type="GeneID" id="27901683"/>
    <dbReference type="eggNOG" id="KOG4230">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003601_2_0_1"/>
    <dbReference type="OMA" id="QPIMFRR"/>
    <dbReference type="OrthoDB" id="5126881at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004329">
        <property type="term" value="F:formate-tetrahydrofolate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009257">
        <property type="term" value="P:10-formyltetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006555">
        <property type="term" value="P:methionine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00477">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000006">
        <property type="entry name" value="Bifunctional protein FolD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000245">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001123">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000005">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.770:FF:000001">
        <property type="entry name" value="Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.410.10:FF:000001">
        <property type="entry name" value="Putative formate--tetrahydrofolate ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.410.10">
        <property type="entry name" value="Formyltetrahydrofolate synthetase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01543">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000559">
        <property type="entry name" value="Formate_THF_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020628">
        <property type="entry name" value="Formate_THF_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020867">
        <property type="entry name" value="THF_DH/CycHdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099:SF5">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01268">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00721">
        <property type="entry name" value="FTHFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00722">
        <property type="entry name" value="FTHFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00766">
        <property type="entry name" value="THF_DHG_CYH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00767">
        <property type="entry name" value="THF_DHG_CYH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0436">Ligase</keyword>
    <keyword evidence="19" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="17" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic" evidence="21">
        <location>
            <begin position="6"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding" evidence="22">
        <location>
            <begin position="143"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00017592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EMF13957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="945" mass="101242" checksum="7487E4841F6CBAB5" modified="2013-05-01" version="1">MTATKIDGKVIAQTIRERISKDIADKQAKNPRYKPSLKIIQVGGREDSSTYVRMKLKAAEEANISCTIDNYDESISQYELLEKIEQYNNDASVHGILVQLPLPKHIDEYEVTSSVADAKDVDGFGALNIGELAKKGGKPLFVPCTPKGVMVLLQESGVDVRGKNAVVIGRSDIVGAPVSYLLRNADATVTVCHSKTADLKEVVKTGDIVIAAIGKPHFVKGEWLKPGAVVIDVGTNSIPDDTKKSGQRLVGDVDYDSAVEVASQITPVPGGVGPMTIAMLLSNVVGAADTYFDRQKSRHITPLPLKLQQPVPSDIAVSRAQHPKLIGKVASEIGVAPHELEPYGHYKAKVSLDVLKRLEHRKNGRYILVAGITPTPLGEGKSTTTIGLTQALAGQLGRIAFANVRQPSQGPTFGIKGGAAGGGYSQVIPMDEFNLHLTGDIHAITAANNLLAAAIDTRMFHEATQGDKALYSRLVPKKKGKREFLPSMLRRMERLGINKTNPDDLTEEEVRRFARLDFDTETITWRRVLDVNDRHLRGITVGQAPTESKAEPRATGFDISVASECMAVLALSTDLSDMRERLGRMVVASSKAGDPITADDIGAAGALAVLMKDAVKPNLMQTLEGTPVFVHAGPFANISIGNSSIIADRIALKLAGTEPDEAAEHNEKVGFVVTEAGFDFTMGGERFMNIKCRASGLVPDVAVIVATVRALKVHGGGPEIKAGAQLDEVYRTENVDILRKGCTNLAKHIENAKSYGVKVVVAINKFETDTEAEAQVIREEAIKAGAEDAIVANHWAEGGKGAVDLANGVIKAAENSKPEEFQLLYQTEGGSVQERIEAIAKKMYGAASVSFSEIAQKKVDTYTKQGYGNLPICIAKTQYSISHDPALKGAPTGFEVPIRDVRMAAGAGYLYALAADIQTIPGLPTAPGYLNVDLDGETGEIDGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M3B307</accession>
    <name>M3B307_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SEPMUDRAFT_162376</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762308.1">
        <property type="nucleotide sequence ID" value="XM_016908001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B307"/>
    <dbReference type="STRING" id="692275.M3B307"/>
    <dbReference type="GeneID" id="27905138"/>
    <dbReference type="eggNOG" id="KOG0039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010365_5_1_1"/>
    <dbReference type="OMA" id="HGFINIP"/>
    <dbReference type="OrthoDB" id="17725at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF28">
        <property type="entry name" value="FRP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="229"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="14">
        <location>
            <begin position="276"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMF14187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="512" mass="55975" checksum="B467482A4D3E7147" modified="2013-05-01" version="1">MSQAANQSAAPAHPEQALHALFAIWDTKNYDTAKYFGAAIGTLIGIFIAAHWTHILLDRLSRSSSTAQLATRSLSLVSRRICSDKVLGCVTVSPAKVLLVLVYTGINATLSFYDRPDKAPIITILARRFGWLALCNICLTVFLGLKNTPLSPLAGYSFDSLNVLHRCTGYTVVLFTVLHAVTYIAGLAKAHALYVLRTPSQAAGIVAALALLCLFVTAIGALRRRMYELFYASHQILAATILVAVGLHRPELAGKALIVTICAAGLWFVDQSLRISRWFYYGVGNHCTLTALAHGATRVTMHRGIRARPGSHAFVWIPGVKSFQRHPFTLVSTDPMEFVIKARDGFSKALHEHACQFPRGKFRASVDGPYGQVPNLTGYQKLVFIAGGSGATFTIALALDWARQSRAPGVYQSLDFIWVVRHAEALQWFANELAELQAHPRISVNLFVTTPVLERHMNLLLGKAVEGLTETESVLVATCGPTNLLARIREAITAVESVAAPRIDMHAEEFTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M3B5L8</accession>
    <name>M3B5L8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_59516</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763208.1">
        <property type="nucleotide sequence ID" value="XM_016909495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B5L8"/>
    <dbReference type="STRING" id="692275.M3B5L8"/>
    <dbReference type="GeneID" id="27906632"/>
    <dbReference type="eggNOG" id="ENOG502SIJF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014597_0_0_1"/>
    <dbReference type="OMA" id="PWTGIAR"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF11">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="17"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF15087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="601" mass="67968" checksum="52AFEF6C7C450E11" modified="2013-05-01" version="1">MPEAGMKRRSTKKSRGGCSRCKAHHLKCDETKPECGRCSRLGIACPGYVQKYKWLNDINNLSAATHATTHNDTDVDLDWLGMTSPPGRPMATPTVAEETPASIPASPLWDSFALQDQPFHVLDFSQLIEPKNTDIATIDVAGPSQRSDMLQSLRTHKREVQPRAQASLAHQPSELLSYYFKNVSKLYAVYDDYRNPFRSVVSNMHSHSQVISLAAQSMAAACLNEIHPRFNIIGRKLRQEAMNLIFSQPQLDSKALLALMMFGPTGNWHDATDLGLDFYAMMRDRIDDLAATGELVQHEVNLNSFNFFREAMVFWEMLLTFVADDTAVRKCSTPLGPVLTCQPAKHIAHPWTGVARDAIEIVADVGRLVRSHRKRHRQQGFVTQAYVHQLNHDLERARELENQLLACRHPDANNIVHPEDAETPVWHLTTLAELYRYAGLLQLYRVFPDTLSSRLSVEDNHAPAPLVPDEHAMDIAHRRSKWLTSFALEALRLLETMPLESGTRDFQPFLLVILSSELVCELPGVDHPDGDEEVDSHFVEVALMRKLVLDRLTTCLTLLPPKPIRVCIDIVKETWRRIDAGQKNVYWLDVVIQNGWETIMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M3B5Z1</accession>
    <name>M3B5Z1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">G-protein beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_147166</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763358.1">
        <property type="nucleotide sequence ID" value="XM_016904127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B5Z1"/>
    <dbReference type="STRING" id="692275.M3B5Z1"/>
    <dbReference type="GeneID" id="27901264"/>
    <dbReference type="eggNOG" id="KOG0286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_34_1"/>
    <dbReference type="OMA" id="PLDSQWV"/>
    <dbReference type="OrthoDB" id="10255630at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000020">
        <property type="entry name" value="Guanine nucleotide-binding protein beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016346">
        <property type="entry name" value="G-protein_beta_1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19850">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25391">
        <property type="entry name" value="WD40_Gbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002394">
        <property type="entry name" value="GN-bd_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="60"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="148"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="189"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="232"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="283"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="318"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="5"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF15237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="350" mass="39045" checksum="6C7942C745005803" modified="2013-05-01" version="1">MADTNESIQTKIQIARRDAEALKDRIKRKKDELADTTLRDVARRQTEQLPRLAMKTKRTLKGHLAKIYAMHWSTDRRHLVSASQDGKLIIWDAYTTNKVHAIPLRSSWVMTCAYSPSGNYVACGGLDNICSIYNLSAREGPTRVARELSGHSGYLSCCRFINDRRILTSSGDMTCVLWDIETGQKITEFADHLGDVMSLSINPLDNNQFVSGACDAFAKLWDIRQQKCTQTFAAHDSDINAIQFFPNGNAFGTGSDDASCRLFDIRADRELQAYTIGEPVCGITSVAFSVSGRLLFAGYDDFECKVWDVLRGERIGTLQGHDNRVSCLGVSNDAMSLCTGSWDSMLRIWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2024-10-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M3BQ05</accession>
    <name>M3BQ05_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_93704</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756364.1">
        <property type="nucleotide sequence ID" value="XM_016910623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BQ05"/>
    <dbReference type="GeneID" id="27907760"/>
    <dbReference type="eggNOG" id="ENOG502RZJU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095770_2_0_1"/>
    <dbReference type="OMA" id="GWNCVSW"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054208">
        <property type="entry name" value="DUF6914"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21858">
        <property type="entry name" value="DUF6914"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF08243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="178" mass="20294" checksum="1974E1064E4EA7BD" modified="2013-05-01" version="1">MPSGKDRLYVALYARGGQSKMPTLEDTYHWALIVGPKDETSGRGWRFHAKEGLKQDGTMGWIFEEKEIPLGATQMLLVRICVGKVEKNSRLKEILRNVPIRDSVAGWNCVYWVVEALKRLQEDGKAMGTSELDWTKLRNTAMAYIERKKQEHRFDGRGSFDMSKPATYDLLEGAETIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M3BQL6</accession>
    <name>M3BQL6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_152084</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756529.1">
        <property type="nucleotide sequence ID" value="XM_016907232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BQL6"/>
    <dbReference type="STRING" id="692275.M3BQL6"/>
    <dbReference type="GeneID" id="27904369"/>
    <dbReference type="eggNOG" id="KOG1996">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025002_1_1_1"/>
    <dbReference type="OMA" id="MNETADQ"/>
    <dbReference type="OrthoDB" id="5411533at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040052">
        <property type="entry name" value="RBM17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13288:SF8">
        <property type="entry name" value="SPLICING FACTOR 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13288">
        <property type="entry name" value="SPLICING FACTOR 45 SPF45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="G-patch" evidence="4">
        <location>
            <begin position="484"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="570"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="34"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="187"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="357"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="515"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="360"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="381"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF08408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="664" mass="70724" checksum="9D3C2E548761B7DC" modified="2013-05-01" version="1">MSAPPPSKGRLTLYEDLLSEDILAQMQARDAAKQAAANAKKAKDASLMFKPSNIGGNKKPQAKTTRKPGFSAMHKFSSSTSNAPAGPSEPSSDAPNAQSQPIPKQQRSYDDWIGNDDEMDFIYDQRNQKREVAKSKKRSKKNKMEEKIITYEDIYDPTTPVPLSGLNRSEVKYDSFAAMQLDIQKARNTELSKKGLGMDPPPGEDPSTQRPITGNKYKSRNVGIAPPASLTSHHAPAADSLSPSRALDNVSDSAGPQASYAPPPPAADIDMNETADQAYARRMAMSGQKSEPTSMRTAHDIPPPRPAPPTFVPASVVPSNLTPASVTPVAATSGLSAADAEKKAKVAAQIAALKARIGQQRASLLSSSPAQPTSTLVPSPAAAPSPSPPPAHSMPVPVPRRALLEDFPPAMSSGPTFNPNHPRHAALVKKYGSSAPPPVSGTTTISAAPVCNPEYLARQQKDTTQPGPQEQQAPAEQRTARPGQESFAERHMKKLGWEKGQGLGASGEGITTALKMQAQKRKRKPDAQGGGYVAPANMGKIVGGKKAKPNPGEGVTSGGELDGMSEVVKLSGMLENLDVEHEIAENNLLQEIGDDMGQEYGQVERLYIWQKKDGGNGEVFVKFTSPLSAVRCMKGMGGTLFAGNEVKAEYWDAALFEEGKYSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M3BRW1</accession>
    <name>M3BRW1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein S2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_151764</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756974.1">
        <property type="nucleotide sequence ID" value="XM_016907030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BRW1"/>
    <dbReference type="STRING" id="692275.M3BRW1"/>
    <dbReference type="GeneID" id="27904167"/>
    <dbReference type="eggNOG" id="KOG0832">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_482470_0_0_1"/>
    <dbReference type="OrthoDB" id="2320368at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_B">
        <property type="entry name" value="Ribosomal_uS2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_uS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005706">
        <property type="entry name" value="Ribosomal_uS2_bac/mit/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_uS2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_uS2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01011">
        <property type="entry name" value="rpsB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S2 PROKARYOTIC AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="Ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00962">
        <property type="entry name" value="RIBOSOMAL_S2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="431"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="431"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="456"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="470"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF08853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="565" mass="61165" checksum="ECF9B0B41BDADC3D" modified="2013-05-01" version="1">MIIRALRLRHGRIALPRRLHHPVTSHLLHIHTSSTRFSSALESTVTPNAEASERVGIPQFAATAKETIGPNTVVDRTVPLNDPNHPVALDYAFFQHNKKHTSGIGSTLAVHYKPHELLTKPPSPRDITLEALIAAQTHIGHATSLWNPSNARYIFGIRGEHDPIHIISPDATASHLRRACRVVSGVADGGGLILFVGTRQGQARAVVKAAELSKGCHLFSKWIPGSITNGQQILGRCEKRVKNEVDEDVTELYGFEDQLFAKAAIKPDLVVCMNPLENYVLLHECGLNNIPTVGIIDTDANPTWVTYPIPANDDSLRAVQFICGVLGRAGQEGQERRLRNAASGYVVYAPIHRLKAPREERSGRGHGNGSVAGSAELMQIKAKSARAGQSGAIEQSLPEEPLFPDDFEGADVSNHEQDRALLAQAERVLFDQDMESKDSDAIPSAEQMSGMDMPDNNNNNNNNTNSASEPDSDSGEDVDLYASFNDTSEPDLSAMDQSLVDETYAQQSETVSDEDAAQFGVASKGAAGADNDSMDSQNSSPIDQVGEVEKELGEEAPEPEIGPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M3BTZ5</accession>
    <name>M3BTZ5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_151157</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL36 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758251.1">
        <property type="nucleotide sequence ID" value="XM_016906637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BTZ5"/>
    <dbReference type="STRING" id="692275.M3BTZ5"/>
    <dbReference type="GeneID" id="27903774"/>
    <dbReference type="eggNOG" id="KOG3452">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140672_1_0_1"/>
    <dbReference type="OMA" id="NKGHKTE"/>
    <dbReference type="OrthoDB" id="9616667at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1760:FF:000003">
        <property type="entry name" value="60S ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1760">
        <property type="entry name" value="60S ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000509">
        <property type="entry name" value="Ribosomal_eL36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038097">
        <property type="entry name" value="Ribosomal_eL36_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10114">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01158">
        <property type="entry name" value="Ribosomal_L36e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01190">
        <property type="entry name" value="RIBOSOMAL_L36E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF10130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="106" mass="12063" checksum="2D269089FB600DB6" modified="2013-05-01" version="1">MPKEVKQRSGIAVGLNAGHKVTPRQPKPRVSRMKGHLSKRTAFVRDIVKEVAGLAPYERRVIELLRNSKDKRARKLAKKRLGTFGRAKRKVDEMTKVIAESRRVGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M3C0X1</accession>
    <name>M3C0X1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_41979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762052.1">
        <property type="nucleotide sequence ID" value="XM_016908849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C0X1"/>
    <dbReference type="STRING" id="692275.M3C0X1"/>
    <dbReference type="GeneID" id="27905986"/>
    <dbReference type="eggNOG" id="ENOG502S4C5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056576_0_0_1"/>
    <dbReference type="OMA" id="NVCWITQ"/>
    <dbReference type="OrthoDB" id="2019666at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="41"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF13931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="237" mass="26438" checksum="98B5CE83DBC92000" modified="2013-05-01" version="1" fragment="single">VSQACALFSSHYGFWAASHNRVRMGPRTLKRKILPHPVDPSCSSICVRALINNKERLIGHVFASQWKISCGEGEWVHVVWITQLVVSQSYRRLGIATTLIQYVQDTFRDWRYAGVLSAHPAAIQAVGRVFGTGGGGVGLVELEDTRRFAKEVMESAPVEYVRKAELRGRLFGEQVAEEVEGMGMASHGGCVAWANTGFYIDHAEVREVLRRLEAEGKKWRLGDLPVGCEFVLVVERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M3C0Z7</accession>
    <name>M3C0Z7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_81749</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF13961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762082.1">
        <property type="nucleotide sequence ID" value="XM_016910285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C0Z7"/>
    <dbReference type="STRING" id="692275.M3C0Z7"/>
    <dbReference type="GeneID" id="27907422"/>
    <dbReference type="eggNOG" id="KOG0269">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002874_0_0_1"/>
    <dbReference type="OMA" id="QTWRIVK"/>
    <dbReference type="OrthoDB" id="60955at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061700">
        <property type="term" value="C:GATOR2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016239">
        <property type="term" value="P:positive regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037590">
        <property type="entry name" value="WDR24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46200">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46200:SF1">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0853">WD repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="119"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="215"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="377"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="425"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="605"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="674"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="733"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1121"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="431"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="679"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="775"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="799"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1121"/>
            <end position="1130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF13961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1145" mass="126367" checksum="5398EEADCF6D5A9E" modified="2013-05-01" version="1">MRSASLSAAQNATASHRTGLEIKTLSINESGTHALIAGKEIFKTVRIEDGRCAEDLNLRSKIRSTPNQASGQPRQIYSIDIADVAWAKGNTGHYVAAATSSGKIIVYDLGHAGLQAAQLIEHQRQVHNVTFSPHQGSLLLSGSQDGTVRLWDIRDVRNQRQVGDIPSKRKFQGQSDGVRDVKWSPTEGLDFAFATDAGELQRWDMRNLKAAKVRVPAHSLACNTVDWHPDGKHIVTAGSDKTIRVFDVSGSRPKRAAWEIKTPHPVMHARWRPSCRSMMPEDNGAGLCTQVVACYDRDHPVMHVWEFRRPLLPFRELHPYPSAPTDMLWHSQDLLWTVGREGTLLQTDIQHAPKLIDRCPVQAIAVSPLGELTFAAQSRKQRRVPKPAPLLETKSSTSTSPPSHLLSRSWADDGVDNSFLRTLPAKGQARAHSNSRVSALPQSSRSPNVSATIKLDDILLNRKTFVPQQIACRGQLPGHNNRKFVAYMAERWATHFQAAPTDENFLAFVSKAFQDNEDHAASMGLLQTAQTWKVVSHCVMDHLAERMAAKQYRALTTTPSVHVISQQQTPIESLASRCASQYMKPPAQSPGSSRPVSTIAQQLAVPESTSNVPTPLARPQTGDRGSLPDLDASEGIALPPSLTSELRPPPSSAPRPLSSSARRLTMDSLAEMQAMQKRQTFEETAERSEMVKRWSSQAKTVLNLDPVDNRGVRIPLSKLEDHGSGESFQFLEDSAGSREASFPASFESSKHKGLDMPSAHPTRPRPSRTQTTESLETDEDEVTGDDGGAGSTDFAFSQEVRERRSKALDNKVDLDTAMASGKMTFLPHTESKKAELHLQMHQAPQHKISRLAVETILDSTPGSPNAVLTDESEVDLEENAIWTLLEMLQELIGFYSNEQTYPQMAAVLLLLVGPLLPCTHPLPASDIHQTVSSYVDYFINSLGWSPYDVPSLVKQCFERPMKAGLQPLQVESIMSTYHEQLLRYQLFNEAAILRKLCYPAYPAVYEDLMGENKVHLMCGQCSRPIAGSSSSLRCPKCKTKEEACPICWMKCSPYQHQGSLLYSCCLLCGHSGHAACLDEWFVHVKGDACPTAGCLCDCVAGTRREAKLAAADAEKRVQAHSRVKSDELKVRQSRAVTGAREQLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M3C4Q6</accession>
    <name>M3C4Q6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aminopeptidase</fullName>
            <ecNumber evidence="11">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SEPMUDRAFT_147203</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9 11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="11"/>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763407.1">
        <property type="nucleotide sequence ID" value="XM_016904145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C4Q6"/>
    <dbReference type="STRING" id="692275.M3C4Q6"/>
    <dbReference type="MEROPS" id="M01.007"/>
    <dbReference type="GeneID" id="27901282"/>
    <dbReference type="eggNOG" id="KOG1046">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003705_0_1_1"/>
    <dbReference type="OMA" id="WNVWSQF"/>
    <dbReference type="OrthoDB" id="10031169at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000001">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.50.20:FF:000002">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000002">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1910:FF:000004">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF171">
        <property type="entry name" value="AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11 15" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 11" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="14">
        <location>
            <begin position="118"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="12">
        <location>
            <begin position="357"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="13">
        <location>
            <begin position="647"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="429"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="432"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMF15286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="985" mass="110263" checksum="D2EB1D764DE8C476" modified="2013-05-01" version="1">MTPSHMHAWSRLTTGTGGAAAAAALRSSHFVHPPPYRYNPIFTTFPFRTSPRSYTSNTTLQTESAPTIRGRGSLHTARAARNTTALLPAVIRNCSSHASSALVRMASDRDVLSDDVKPSNYAISLNNLSAGEPWTYQGKVDIELEVKKPTKSITLNTFELKVHSAEFVSDSGKHSSAVKASNISYDNKNQRCTFTFDQELPQSPKSVLSIAFEGIMNNHMAGFYRSKYKPAVEAAKGVARDAENHYMFSTQFESSDARRAFPCFDEPNLKATFDFEIEIPEDLVALSNMQEKATKKSKDGYKIVSFDRTPVMSTYLLAWAFGDFEYVEDFTRRKYNGKSLPVRVYTTKGLKQQGQLALESAHQIVDYFSEIFDIDYPLPKVDLLAVHEFSHGAMENWGLITYRTTAVLFDEYASDQKYRNRVVYVVAHELAHQWFGNLVTMDWWNELWLNEGFATWVGWYAVDHLHPDWDVWGQFVTDSMQMAFQLDSLRTSHPIEVPVRNALEVDQIFDHISYLKGSSVIRMLASHLGVKTFLKGVSDYLKANTYSNATTNDLWSALSKASGQDVNEFMDPWIRKIGFPVVTVAEEPGQISVEQSRFLSAGDVKPEEDGTTWWIPLGLKTGPQATEAQREALTTRKDTYRDIDTSFYKVNSDQTGFYRTNLPPPRLVELSKHLDKLSVQDKIGLVGDAAALAVAGQGTTSAVLSFLEGFSTETNYLVWSEVLTSLGKIRRIFSSDAEVSQALREYTLRLVTPAADKIGWTFSPSDDYLTGQLRALLLSTAGLVGHEQVVAEAQRQFQAFLDGDAKAIHPSLRAAVYKISIKNGGEAAYKAVQKEFLTTKSIDGREITLQAMGQVQSQELANDYLKFAFGGNVPIQDLHSVGASLGNNSKVRETVWQYIKAEWPAIREKLGGNMVVLERFLRTSLQKFADAGVERDITTFFSDKDTTGYDRGLAVVADTIIGNARYRERDVENTREWLKAHGYAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M3C565</accession>
    <name>M3C565_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">tRNA pseudouridine synthase D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_147300</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase TruD family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763522.1">
        <property type="nucleotide sequence ID" value="XM_016904210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C565"/>
    <dbReference type="STRING" id="692275.M3C565"/>
    <dbReference type="GeneID" id="27901347"/>
    <dbReference type="eggNOG" id="KOG2339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005281_0_0_1"/>
    <dbReference type="OMA" id="RSGILHY"/>
    <dbReference type="OrthoDB" id="447290at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02576">
        <property type="entry name" value="PseudoU_synth_ScPUS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.20">
        <property type="entry name" value="TruD, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001656">
        <property type="entry name" value="PsdUridine_synth_TruD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020119">
        <property type="entry name" value="PsdUridine_synth_TruD_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011760">
        <property type="entry name" value="PsdUridine_synth_TruD_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042214">
        <property type="entry name" value="TruD_catalytic"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00094">
        <property type="entry name" value="tRNA_TruD_broad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326:SF21">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE PUS7L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01142">
        <property type="entry name" value="TruD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037016">
        <property type="entry name" value="Pseudouridin_synth_euk_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50984">
        <property type="entry name" value="TRUD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01268">
        <property type="entry name" value="UPF0024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TRUD" evidence="5">
        <location>
            <begin position="392"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="55"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="571"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="581"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF15401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="777" mass="85156" checksum="E9082606CEA74CE5" modified="2013-05-01" version="1">MATLLSSERDQISQERAVGMRAFVRPDIPGFSCIVKQRYTDFLVNEVLPNDEVLHLVASEPDQERKRKREDGGEQPQKKQKPEDATPADAVSNGTSNHVNAESQSEDLSKANATQPDPAAPSTPLEAPNTNVKAKKEEAIASISDADKEVLNNVFGEESTAAIINLYASVVAFPERKPRDHPTVNSPPLAEKSKRTEAHLCVRRIFDSRLETTTVQDQQHQSGPGTVIAIRAAPPKAAIAPSAKRNGDVQRGKQNWAELGGEYLHFSLYKENKDTMEVLYFIASQLKMNMKHLGFAGTKDRRGVTVQRVSAHRVNRGRIEALNKHAKGWRVGGPWEYKNYELTLGMSNGNQFLLTLRDAHVGDPNEGGDMETRLRNVKACAEAGAKSLSENGYLNYYGLQRFGTHSIGTHGVGMQILQGDLKGAVDSILAYDEALLQENQVSESGADSNGTDRNVPLRKIPQDDINRATAIHAFRQSGTSSRALSILQGNRFSAEKGMITHLGKKDRQTGQRPNENDFQGALMTIQRNLRLMYVHAYQSFVWNMVAGKRWELHGAKLVEGDLVVVGEKEAAEGAPNGAAAPKDETDEHGEPIIHPSASADAGNPGATGELDDPFVRARPLSKEEAESGRFNIFDVVLPLPGYDVIYPKNEIGQYYVDFMASEEGGKLDPYNMRRTSKDFSLSGGYRKLMARPLGAGVEVEVKAYNTPEEQLVQTDLDKLRSAGKHVDSVANGATEKDKVAVILKLQLGSSQYATMALRELTKGAAMGFTPSYSVANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M3C5G4</accession>
    <name>M3C5G4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP synthase subunit beta</fullName>
            <ecNumber evidence="13">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SEPMUDRAFT_147371</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="13"/>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763622.1">
        <property type="nucleotide sequence ID" value="XM_016904254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C5G4"/>
    <dbReference type="STRING" id="692275.M3C5G4"/>
    <dbReference type="GeneID" id="27901391"/>
    <dbReference type="eggNOG" id="KOG1350">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022398_0_2_1"/>
    <dbReference type="OMA" id="SMEEGGW"/>
    <dbReference type="OrthoDB" id="14523at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042776">
        <property type="term" value="P:proton motive force-driven mitochondrial ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18110">
        <property type="entry name" value="ATP-synt_F1_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18115">
        <property type="entry name" value="ATP-synt_F1_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01133">
        <property type="entry name" value="F1-ATPase_beta_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1140.10:FF:000001">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.170:FF:000005">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000026">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01347">
        <property type="entry name" value="ATP_synth_beta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050053">
        <property type="entry name" value="ATPase_alpha/beta_chains"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01039">
        <property type="entry name" value="atpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184">
        <property type="entry name" value="ATP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184:SF71">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039072">
        <property type="entry name" value="ATPase_subunit_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 13" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="182"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMF15501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="513" mass="55270" checksum="B49E6A7C5F950EDA" modified="2013-05-01" version="1">MLKNGVARALRTSTFRPALRQVKPQSYIPAISQRFASSDSARDGKVHQVIGAVVDVKFPTDQLPPILNALETTNGGQKLVLEVSQHLGENVVRCIAMDGTEGLVRGQTATDSGSPILIPVGPGTLGRIMNVTGDPIDERGPIKHEKKLPIHAEPPAFVDQSTSAEVLATGIKVVDLLAPYARGGKIGLFGGAGVGKTVFIQELINNIAKAHGGYSVFTGVGERTREGNDLYHEMQETGVIQLEGESKVALVFGQMNEPPGARARVALTGLTVLEYFRDEEGQDVLLFIDNIFRFTQAGAEVSALLGRIPSAVGYQPTLAIDMGGMQERITTTKKGSITSVQAVYVPADDLTDPAPATTFAHLDATTVLSRGISELGIYPAVDPLDSASRMLDPRIIGQDHYDTALKVQQMLQEYKSLQDIIAILGMDELSEQDKLTVERARKIQRFLSQPFTVAQVFTGIEGKLVDLKETISSFKKIMEGEGDDLPEGAFYMVGGFADAQEKGKKILADLEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M3C735</accession>
    <name>M3C735_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Dynamin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SEPMUDRAFT_124172</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF16061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764182.1">
        <property type="nucleotide sequence ID" value="XM_016901892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C735"/>
    <dbReference type="STRING" id="692275.M3C735"/>
    <dbReference type="GeneID" id="27899029"/>
    <dbReference type="eggNOG" id="KOG0448">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011752_0_0_1"/>
    <dbReference type="OMA" id="RCERMIL"/>
    <dbReference type="OrthoDB" id="9984778at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008053">
        <property type="term" value="P:mitochondrial fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051646">
        <property type="term" value="P:mitochondrion localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000638">
        <property type="entry name" value="Transmembrane GTPase Fzo1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027094">
        <property type="entry name" value="Mitofusin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465:SF0">
        <property type="entry name" value="SARCALUMENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465">
        <property type="entry name" value="TRANSMEMBRANE GTPASE FZO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="13">
        <location>
            <begin position="277"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="146"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="495"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="619"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="151"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="619"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMF16061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="940" mass="103138" checksum="2AE037AC00E43EB9" modified="2013-05-01" version="1">MSSNNPSGDGGAGPSSSRGGDASSSRRGPGSRPQYMTVGSGSTSEAASRLQALLDEDSGYGGSNTGDDTMENAWHPGPAVDRYTPAHTPARPGESNPDSENESRALAAHVHQMFYNKNRTALGRAINQTVETLKKLQEMNTKWPAHYPTVQRPPTPPPARPAPRPGLAHTQTTFDLDSIESAPLRPHLPRRAGTTLGMDPESSTNAERRGSAPTTEPRLVTPQLAQDFSVLKIELKMEGLAQSDIVHSLEKQSVAALLDNQINKSVRHLFALRERIEDTSSKVLITGDLNAGKSTFCNALLRRKVLPEDQQPCTAIFCEVLDCRENGNLEEVHAIPHGAVYDRNDESTYHVYQLKQLDDIVIDSDRYQMCKIYIRDARPVDQSLLNNGVVDIALIDAPGLNNDSLKTTAVFARQEEIDVVVFVVSAANHFTLSAKEFIFNAAREKAYMFMVVNGYDQIRDKKRCQEMILKQVAHLSPATFKESSELVHFVSSNAIPVGPGPGGPPGGGSSGGSHFDSGDSSSDKGAEDDDGINGKHGEPGSPPDKKKGKGKEKEALDDFSELEASLRRFVLEKRARSKLAPAKTYLMNVLGDLGTLAGVNKDVAQSELDRVTEELRKLEPEYEASKKSRSEADEHVASNIEETTNDVYRLTRHTITDSINKVAESDLGVDYPGVLGAYGYAEDLKTAMLQQITETVRWCEERAREKTVTGVSSIKSLGILHLGDNYVDLQFRSEKMFKSRRDALARQVDFEPELWDFFDFASIWERQEKVAGTSMAVTVAGVVGTRLIGGFGWVDGALTATKIVGANNLRRALIPSVILAFALGVSYAVSQIPHSLPRRLSTKLAAQLAALDYTHSNSLRISSEVRRALKFPADKLREGLQRNMEQLQERKKETDKIRTENEVARKYFGNLVRDSNDIRSRVDRVDLEGPAPGIAAAYDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M3C8Z5</accession>
    <name>M3C8Z5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_53918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756461.1">
        <property type="nucleotide sequence ID" value="XM_016909281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C8Z5"/>
    <dbReference type="STRING" id="692275.M3C8Z5"/>
    <dbReference type="GeneID" id="27906418"/>
    <dbReference type="eggNOG" id="ENOG502SZY2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_152673_0_0_1"/>
    <dbReference type="OMA" id="DYHATSG"/>
    <dbReference type="OrthoDB" id="2507140at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032244" description="Extracellular membrane protein CFEM domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF08340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="104" mass="10877" checksum="2814F6833F0292F0" modified="2013-05-01" version="1">MHASAAFFVALAGFATAQSTSSVLPVSGCGESIDLIIQSCLGTTQAQYNACTPNDWSCLCEQANNVLTCYNNCPSAPQRFGFEQTKVAQCNAASAYVHPSSACN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M3CBD1</accession>
    <name>M3CBD1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_121038</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF09160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757281.1">
        <property type="nucleotide sequence ID" value="XM_016901658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CBD1"/>
    <dbReference type="STRING" id="692275.M3CBD1"/>
    <dbReference type="GeneID" id="27898795"/>
    <dbReference type="eggNOG" id="KOG0769">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_6_3_1"/>
    <dbReference type="OMA" id="PLEMINT"/>
    <dbReference type="OrthoDB" id="446044at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015217">
        <property type="term" value="F:ADP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015867">
        <property type="term" value="P:ATP transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052217">
        <property type="entry name" value="Mito/Peroxisomal_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939:SF1">
        <property type="entry name" value="MITOCHONDRIAL THIAMINE PYROPHOSPHATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="13"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="118"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="214"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF09160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="349" mass="37681" checksum="FC28C7A37393A148" modified="2013-05-01" version="1">MAPAPSKQELPAWGLALAGSAGALVANSCVYPLDLVKTRLQTQVKRTANDTHVEDEGHVHYEGTLHAINHIIAEEGVSGLFNGLAGNLLGVVSTNFAYFYWYSLVREMYHARVDSKGTSTAVELGLGAVAGALAQLFTIPIAVVTTRQQGQRKGEKKGIFATAKEVVDQDGVAGLWRGIKASMVLVVNPSITYGAYERLRTLMFPGKANLAPHEAFLLGALSKMLATIATQPLIIAKVGLQSRPPPQRMGKPFTSFQEVMKFTVERDGILGLWKGVAPQLMKGFLVQGILMMTKERVELLFVLLFRAARKMRQEQLEKLAKIAAEKVEQGKAAAAALETAQQAKVAASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M3CBV0</accession>
    <name>M3CBV0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Thioesterase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_150996</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF09892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758013.1">
        <property type="nucleotide sequence ID" value="XM_016906531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CBV0"/>
    <dbReference type="STRING" id="692275.M3CBV0"/>
    <dbReference type="GeneID" id="27903668"/>
    <dbReference type="eggNOG" id="ENOG502S4UX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050730_0_0_1"/>
    <dbReference type="OMA" id="CDMFITP"/>
    <dbReference type="OrthoDB" id="2532955at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049450">
        <property type="entry name" value="ACOT8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052389">
        <property type="entry name" value="Sec_Metab_Biosynth-Assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38110">
        <property type="entry name" value="CHROMOSOME 23, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38110:SF1">
        <property type="entry name" value="THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20789">
        <property type="entry name" value="4HBT_3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase-like N-terminal HotDog" evidence="1">
        <location>
            <begin position="22"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA thioesterase-like C-terminal" evidence="2">
        <location>
            <begin position="157"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF09892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="325" mass="36960" checksum="FBF1D391D32B1714" modified="2013-05-01" version="1">MALERATTVRQVDSHTYSADFAEDWCIGSVPHGGYVTTTIQKAVKKHFETTLSDQDQPHILALHLDFLRRTQTGPATFTIKDVKLGRQTSVVHISLSQDGREEVVGYCTQTNLTKESGLSFSTNWTPQPPITPLTSTLTALSLGQDPAWTELSDWPNSNFRKATRQIRSFFPRAGQPSQNIYDEWICLQDPSENWTNDNLGFLIDLFPQILETYILQGFDQYNPTLLETPSGRTLRESKKSETPFWYPTVLLNLDVKKLLPQGGVRFLSTRLQTKVIREGRYDLEVVVWDEMGEVVALSHHVCFVVSAERNLRKRRTREEGGSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>M3CDY6</accession>
    <name>M3CDY6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP-dependent 6-phosphofructokinase</fullName>
            <shortName evidence="14">ATP-PFK</shortName>
            <shortName evidence="14">Phosphofructokinase</shortName>
            <ecNumber evidence="14">2.7.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Phosphohexokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SEPMUDRAFT_150222</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14 15">
            <text>beta-D-fructose 6-phosphate + ATP = beta-D-fructose 1,6-bisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="14">Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 14 15">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="14"/>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759362.1">
        <property type="nucleotide sequence ID" value="XM_016906027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CDY6"/>
    <dbReference type="STRING" id="692275.M3CDY6"/>
    <dbReference type="GeneID" id="27903164"/>
    <dbReference type="eggNOG" id="KOG2440">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011053_0_0_1"/>
    <dbReference type="OMA" id="EWQDQMC"/>
    <dbReference type="OrthoDB" id="537915at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005945">
        <property type="term" value="C:6-phosphofructokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070095">
        <property type="term" value="F:fructose-6-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061621">
        <property type="term" value="P:canonical glycolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.460:FF:000007">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.460:FF:000008">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="entry name" value="Phosphofructokinase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03184">
        <property type="entry name" value="Phosphofructokinase_I_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009161">
        <property type="entry name" value="6-Pfructokinase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02478">
        <property type="entry name" value="6PF1K_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697:SF4">
        <property type="entry name" value="ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000533">
        <property type="entry name" value="ATP_PFK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="Phosphofructokinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 14" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="10 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 14 15" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 14 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphofructokinase" evidence="17">
        <location>
            <begin position="17"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphofructokinase" evidence="17">
        <location>
            <begin position="405"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal catalytic PFK domain 1" evidence="14">
        <location>
            <begin position="1"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interdomain linker" evidence="14">
        <location>
            <begin position="391"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal regulatory PFK domain 2" evidence="14">
        <location>
            <begin position="405"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="771"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="88"/>
            <end position="89"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="118"/>
            <end position="121"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="164"/>
            <end position="166"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="208"/>
            <end position="210"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="298"/>
            <end position="301"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <position position="481"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="538"/>
            <end position="542"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="576"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="583"/>
            <end position="585"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <position position="643"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="669"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="675"/>
            <end position="678"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <position position="747"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR000533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMF11241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="803" mass="87272" checksum="5C37B7BBFD99D7ED" modified="2013-05-01" version="1">MAQVNLSPPSMPWGKKRIAVMTSGGDSPGMSAAVRAVVRQSLSAGCTAYAIYEGYQGLVDGGDMIKEMKWEDVRGWISEGGTLIGTARCKAFMERPGRLTAANNMIEKGIDALIICGGDGSLTGADKFRGEWPSLMDELVSTGKRKEEDVKPYRHLNIVGLVGSIDNDLSSTDATIGAYSSLERICQSIDYIDATALSHQRAFVIEVMGRHCGWLALMAGVACGADFVFCPENPPSENWEAEMCSIVQKHRTMGKRKTIVIVAEGAHDRNLKAISPYMVKDLLTNNVGLDTRVTTLGHVQRGGPPCAYDRMLATLQGVEAVKAVLEATPETPSPVICMVENKIVRKDMIEAIRLTKKVAEDIAKKDFDAAMKGRDAEFAEFQQAFNMTTSTDNTKTLVPKEKRMRVGIIHVGAPAGGMNAATRAAVAYCLSRGHTPVALHNGFPGLCRHHDDKPLGSVREISWLDAENWGSKGGSELGTNRALPSEDFKTVAFCFEKYKIDALFVVGGFEAFTAVSELRKARADYDAFKIPMTILPATVSNNVPGTEFSIGSDTCLNALINYCDAIKQSASASRRRVFVVETQGGASGYIAILAGLAIGAVAVYTPEEGINLNMLVQDIKFLKDQFAMDKGHARSGKIILRNEKASKVYTTEFIADAIKEESNGKFDSRYAVPGHFQQGDIPSPMDRTRAVRFGVKSLQYLEAFAGKSKQEIADDPMSVAVIGIRGAKVKFSAMEKIEREETDWKDRRPKDEFWMGLVDVVDTLSGRSLVKASRTSMRTPLPGTPLPGTPDVQGMQKQNGTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M3CEQ4</accession>
    <name>M3CEQ4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_127044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759647.1">
        <property type="nucleotide sequence ID" value="XM_016902117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CEQ4"/>
    <dbReference type="GeneID" id="27899254"/>
    <dbReference type="HOGENOM" id="CLU_2544057_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF11526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="83" mass="9428" checksum="1C5BBDBB8E97A324" modified="2013-05-01" version="1">MDLTKSKNSGMSDVEEEEEEEEEEEEEEEVVAEYWPRSSRLTLGTVLSVLHFPIASGGNLQRLEFLAEVMSAAEDDTVRRSYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M3CGS1</accession>
    <name>M3CGS1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NGG1 interacting factor Nif3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_126054</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase I type 2/NIF3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF13008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761129.1">
        <property type="nucleotide sequence ID" value="XM_016902032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CGS1"/>
    <dbReference type="STRING" id="692275.M3CGS1"/>
    <dbReference type="GeneID" id="27899169"/>
    <dbReference type="eggNOG" id="KOG4131">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037423_0_1_1"/>
    <dbReference type="OMA" id="NFDKTHL"/>
    <dbReference type="OrthoDB" id="3345469at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1390.30:FF:000001">
        <property type="entry name" value="GTP cyclohydrolase 1 type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.30">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002678">
        <property type="entry name" value="DUF34/NIF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00486">
        <property type="entry name" value="YbgI_SA1388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799">
        <property type="entry name" value="NGG1 INTERACTING FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799:SF13">
        <property type="entry name" value="NIF3-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01784">
        <property type="entry name" value="DUF34_NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="136"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602678-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF13008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="388" mass="42262" checksum="09D46427C8CDB609" modified="2013-05-01" version="1">MAHSTVASPYSRAVVNAMRRLYPEALADKSFDNTGLLLESPFDPLRRNMNSVLLTVDLTKAVADEAIERQDSVIIAYHPIIFRGLKSLTLADTQQQTLLRLAAEGISVYSPHTAVDCARGGLGDWLADIVTGTPTNASELDDDLSEASPDKSSPKETPAQTASVDAEDKSSSLEVKRPTYMLQHHPSQLDLNDRALKMGDSGHQRYPITKTSVSGHEGAGMGRIIRFSQPVPLLEIIDRIGLGMGSPKGFPIAVPQGKQASDMMISSIALCAGSGGGLFSQAEKNGEDVDLYFTGELSHHEALAAIEKGKCVVMLFHSNTERGFLHSVLKGQLERAVGEEWEKIRSEERSQKNLSEDYLEVLNDSSSEIHVSEVDRDPYGIMISKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M3CHG5</accession>
    <name>M3CHG5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_148598</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761354.1">
        <property type="nucleotide sequence ID" value="XM_016905022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CHG5"/>
    <dbReference type="STRING" id="692275.M3CHG5"/>
    <dbReference type="GeneID" id="27902159"/>
    <dbReference type="eggNOG" id="KOG0769">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_6_2_1"/>
    <dbReference type="OMA" id="FYNYLRP"/>
    <dbReference type="OrthoDB" id="18574at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015217">
        <property type="term" value="F:ADP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052217">
        <property type="entry name" value="Mito/Peroxisomal_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939:SF2">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G13870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="41"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="152"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="389"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="299"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF13233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="431" mass="45931" checksum="81DDC2A0D7E39F9E" modified="2013-05-01" version="1">MSDRAAGFFTYNSQLDAFTLYHLTTEEQYAAKAGGVIGPVLPALGHALAGGLASALSKAAVYPIDTIVTRMQVQKHLKGDKEAPSAAGDANVFYHNPVDAANKIYKNEGGLKGFYAGLGSDVVKAIADSFLFFLAYNAVRDQMLKREGAKRLPVLKELSVGIIAGALSKAVTQPISNIVVRQQTAALIAARDPESSSTPGEADQVSVKEIARQIRNEKGVAGFWAGYSPQIILTLNPAITFAVDNLLKGLVPKAKRDSASVTFLVAAISKVVATSLTYPVMLAKSRAQATRGSSTETEASEHHVSAKNSADRKAQVKQAIQKVAQLLEGQTRIFVALQKIYRKEGIAGLYCGLEGEVVKGFLQHGITMAAKDGVHVGVVQLYYIVLRLTKRWDAELAKAQSQAAELANDAKHSIENATNVTVEAAKKAVGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M3CMJ0</accession>
    <name>M3CMJ0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PAN2-PAN3 deadenylation complex subunit PAN3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">PAB1P-dependent poly(A)-specific ribonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Poly(A)-nuclease deadenylation complex subunit 3</fullName>
            <shortName evidence="8">PAN deadenylation complex subunit 3</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">PAN3</name>
        <name evidence="11" type="ORF">SEPMUDRAFT_123412</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and with PAB1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer. Forms a heterotrimer with a catalytic subunit PAN2 to form the poly(A)-nuclease (PAN) deadenylation complex. Interacts (via PAM-2 motif) with poly(A)-binding protein PAB1 (via PABC domain), conferring substrate specificity of the enzyme complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">Contains a pseudokinase domain. The protein kinase domain is predicted to be catalytically inactive because some of the residues important for catalytic activity are substituted and it lacks the equivalent of the binding site for a peptide substrate. However, it has retained an ATP-binding site and ATP-binding is required for mRNA degradation, stimulating the activity of the PAN2 nuclease in vitro. The nucleotide-binding site is juxtaposed to the RNase active site of PAN2 in the complex and may actually bind nucleosides of a poly(A) RNA rather than ATP, feeding the poly(A)-tail to the active site of the deadenylase and thus increasing the efficiency with which this distributive enzyme degrades oligo(A) RNAs.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">The N-terminal zinc finger binds to poly(A) RNA.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">The pseudokinase domain, the coiled-coil (CC), and C-terminal knob domain (CK) form a structural unit (PKC) that forms an extensive high-affinity interaction surface for PAN2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. PAN3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763144.1">
        <property type="nucleotide sequence ID" value="XM_016901838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CMJ0"/>
    <dbReference type="STRING" id="692275.M3CMJ0"/>
    <dbReference type="GeneID" id="27898975"/>
    <dbReference type="eggNOG" id="KOG3741">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016423_1_0_1"/>
    <dbReference type="OMA" id="YVFHSVD"/>
    <dbReference type="OrthoDB" id="204958at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031251">
        <property type="term" value="C:PAN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3700:FF:000001">
        <property type="entry name" value="PAN2-PAN3 deadenylation complex subunit PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.5160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03181">
        <property type="entry name" value="PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030844">
        <property type="entry name" value="PAN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041332">
        <property type="entry name" value="Pan3_CK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12272">
        <property type="entry name" value="DEADENYLATION COMPLEX SUBUNIT PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12272:SF11">
        <property type="entry name" value="PAN2-PAN3 DEADENYLATION COMPLEX SUBUNIT PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18101">
        <property type="entry name" value="Pan3_CK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Pan3 C-terminal knob" evidence="10">
        <location>
            <begin position="527"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Knob domain" evidence="8">
        <location>
            <begin position="573"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="534"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="362"/>
            <end position="369"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="421"/>
            <end position="422"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF15023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="685" mass="76056" checksum="C64ADE3D189BF556" modified="2013-05-01" version="1">MANVTPRASDSRRSNRHENRPPPGPHQLCRNGPGCRKLQEGTCYYSHDFSGSMSPNGTNNPSQRALNVQSPAFTPTLAHAKPVKQMGISPKAVAAAAFTPRGSGSVTPAAPLHSKQLSEEFIPQQPFQQIQQISEFVPGPDFVPGQDFLSGQQFMGVPSLNSQTHTSTQYNPYGDFAQQGLSSMETSHIHVNPYAHHAGSGGVQPYYQNSTDYSYPLNYHLYAPFGPRRENLTAYQRSTADFFIPDDIREELQRKSEMTLQTFANSTLPQSVEHFHSLVALNVRSSKSPATFGYPSSIYKATSKRDGHTYALRRIAGFRLNSEAQIRTINAWKRLSSSSLVAIHDAFTGRWFGDSSLIIVTDYHPCSQSLAEKFFGATRDFKKSVSQVVPESELWGYIVQLTSALRTIHGAGQAAQTVMASKVLLTSKNRVRLNGCAILDIIQYDQRPSMLELQKADLRDLGRLILSIAARNQLAHKDAAKALELISRSYTERFRSCIAWLLAPPPLQQDGDGSVASSTTGEYSANALLTSIADKVIDIYDKGLHYEDEMTAQLSRELENGRVLRLLTKLAVILERPDISITGNTRGNPALLNQPSAAWSETGERYYLKLFRDYVFHQIDAEGRPVIDLGHILTCLNKVDAGIDEKIQLISRDEESLFVVSYKEVKRGIESAWMEILKASNTARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M3CMS4</accession>
    <name>M3CMS4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bystin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_147078</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bystin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763234.1">
        <property type="nucleotide sequence ID" value="XM_016904070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CMS4"/>
    <dbReference type="STRING" id="692275.M3CMS4"/>
    <dbReference type="GeneID" id="27901207"/>
    <dbReference type="eggNOG" id="KOG3871">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029727_0_1_1"/>
    <dbReference type="OMA" id="TKLPVIW"/>
    <dbReference type="OrthoDB" id="2192561at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007955">
        <property type="entry name" value="Bystin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12821">
        <property type="entry name" value="BYSTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12821:SF0">
        <property type="entry name" value="BYSTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05291">
        <property type="entry name" value="Bystin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="91"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF15113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="507" mass="56430" checksum="47CFB669C4003D1D" modified="2013-05-01" version="1">MPKAARSNSTARQERRHNPLSEEYSPTTPLKQKAGKKRKSTSEANGQDGYVDSKSSRRILDLGQDLVDEDEAERQAKRPAVANPAFSLRADEDEDEDGGAEVGEYDEEEAWASDEEVEEVEVDPEDNETWNRLMGGGEDPSKLFDLAGQPHHDGGDEEEEPRGPDYLSNLILEKIAAHEAAQAGGDPDAAPRIIGGGTLEDAVQMDPKVVEVYTQVGLILSRYKSGKLPKPFKVLPTLPQWDILVEITRPEDWTPNAIYEATKIFTSSRPAVAQAFCQDVLLPRVREDIRETKKLNVHLYKAMKKSLYKPAAFFRGLLFPLVGSGTCTLREAQIISSVLQRVSIPVLHSATALYRLCEIAADQMMHDVEAAGACNMFIRTLLEKKYALPFRVVDALVFHFLRFRQMQDSNGEDVNMEGTTTHGFPGKKGAGDPRLPVIWHQCLLAFAQRYKNEITEDQREALLDLLLVRGHKQIGPEVRRELLEGRGRGVIAEEALADGGDDTMMDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M3CUP2</accession>
    <name>M3CUP2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_121772</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456305">
        <property type="protein sequence ID" value="EMF07882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756003.1">
        <property type="nucleotide sequence ID" value="XM_016901724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CUP2"/>
    <dbReference type="GeneID" id="27898861"/>
    <dbReference type="HOGENOM" id="CLU_1994040_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF07882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="112" mass="12908" checksum="265C315365B8BC2E" modified="2013-05-01" version="1">MPKRKSNALEALANKRAKLGAASKLLEEYSLKPNTLRDRERTAAIDEEKRAQDRYRKARNESFARFKKAQIKDTKKQTGKSAILPPDEQAKIDKADWFLELGDIDSKERLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M3CWD6</accession>
    <name>M3CWD6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL3m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_145060</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756553.1">
        <property type="nucleotide sequence ID" value="XM_016903089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CWD6"/>
    <dbReference type="STRING" id="692275.M3CWD6"/>
    <dbReference type="GeneID" id="27900226"/>
    <dbReference type="eggNOG" id="KOG3141">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044142_0_1_1"/>
    <dbReference type="OMA" id="GKNIPCT"/>
    <dbReference type="OrthoDB" id="274683at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000004">
        <property type="entry name" value="50S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.810:FF:000001">
        <property type="entry name" value="50S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01325_B">
        <property type="entry name" value="Ribosomal_uL3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_uL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019927">
        <property type="entry name" value="Ribosomal_uL3_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03625">
        <property type="entry name" value="L3_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229:SF8">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL3M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF08432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="306" mass="33175" checksum="265DB2F7A709B54A" modified="2013-05-01" version="1">MPLKPPSTALLALPPRFLCPSLPRQFIRTIRSIAPPKKLHKFNHGKSLPTLQATAKAAFERREHNFPLRTGAIAIKKGMTGIYDPTTAKREPCTVLQLDRCQVVSHKRREIHGYWAVQVGFGTKEARNVTRPERGHFAAQGVPIKKELAEFRVKNEQGLPAVGSVISADLFQEGQFVDARGVTRGMGFAGGMKRWGFSGQPASHGTSLTHRAMGSAGASQGSGSRVLPGKKMAGRMGAENCTVQNLRVMKVDRENGIVVVQGAVPGPRNSIVTIQDAIKKPWPEVEPDVGITAWVRSGESPTPVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M3CY59</accession>
    <name>M3CY59_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_121396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756742.1">
        <property type="nucleotide sequence ID" value="XM_016901685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CY59"/>
    <dbReference type="GeneID" id="27898822"/>
    <dbReference type="eggNOG" id="ENOG502TAXQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2591319_0_0_1"/>
    <dbReference type="OMA" id="FICCECR"/>
    <dbReference type="OrthoDB" id="3833019at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF08621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="80" mass="8634" checksum="F2C4A786684CCC17" modified="2013-05-01" version="1">MSAQADVEMQYQAPTQMDPAATSDTSSTAQKTCAKEQPKRTFLGMRGGGIIFDLCACFICCECRGENVEFKHSLSTSADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M3CYR6</accession>
    <name>M3CYR6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_165565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF09799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757920.1">
        <property type="nucleotide sequence ID" value="XM_016908179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CYR6"/>
    <dbReference type="STRING" id="692275.M3CYR6"/>
    <dbReference type="GeneID" id="27905316"/>
    <dbReference type="eggNOG" id="ENOG502SIYK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019189_3_0_1"/>
    <dbReference type="OMA" id="QGSIDRH"/>
    <dbReference type="OrthoDB" id="2831558at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF09799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="443" mass="50114" checksum="480008F84AD56D54" modified="2013-05-01" version="1">MAVYSLYNELLCDRVVSLSPGATAVRSWRKKEGGFNRIFIMNLDSGSKLVAEIPYPGVGLPQRRATVSEVATNPVECEYIIMTEARGVLLSGKWPQMTGPQRVGCISPIFQNVKQLQDLEFPAYGSLYFHEEISLISTKKFDLDCGICLSQYCGIGYWDSDSTSRAPIHRGPWRDLQGFADSLVDVGIARVPTELPTIASGPPYQGLPQEHRDMLTTALSIFQAISTSPSVQKASKPLLYHPDLHARNIFVSEHTPTLQGTSVEPAFWHADVTPDFAHPNDETSAKTCAVYIAVLIPKLAAAQRVDENIFRPYQYCFRTWKDGIPAYRHELAETWECWNEMNELRGVDRPQQQQQTDVKFIITQDKRAYDLFVTAQMMKTDFANLLNCETDGWVRAETYEATKKKRYHDKLFHGALHAVLDDANDSEETTKNEETTFRALWPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M3CZP0</accession>
    <name>M3CZP0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_50405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758230.1">
        <property type="nucleotide sequence ID" value="XM_016909162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CZP0"/>
    <dbReference type="STRING" id="692275.M3CZP0"/>
    <dbReference type="GeneID" id="27906299"/>
    <dbReference type="eggNOG" id="ENOG502SHYF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_839590_0_0_1"/>
    <dbReference type="OMA" id="CETVWRS"/>
    <dbReference type="OrthoDB" id="2821871at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF10109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="342" mass="40232" checksum="740C94EA5F78EB76" modified="2013-05-01" version="1">MVEQKPAADTKATPYKWIATRIESLDPYKDYEEIVRLSSCYYSNDFINNLMYGVILPTLLKPEWAARAIWREDGGKMLHRANIRVEDTEHYNMTWLYYGPSDKKCQDAIEFVNNYHARLEKVTPNCYGHNDDYVYTLASAALTGDRFAKRLGLPRYTRNQRIAHYIFYREMSKQFVSHHPGGERRPLTGFPESWEHAEKWCEEHEKKPVPKDPRSELIAESAFEQFGTRWFPRGLQWMGRSIQVSLIQPDDLKAIGVQDVYPWTRAFVIFFMGWMLWLLAFAPDPSPNDSIIEKHERVPKEEKKARLKELNQADKMFCPYFAAKYKDVRPDCPHFSKLAEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>M3D2R9</accession>
    <name>M3D2R9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_108026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760636.1">
        <property type="nucleotide sequence ID" value="XM_016900713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D2R9"/>
    <dbReference type="GeneID" id="27897850"/>
    <dbReference type="HOGENOM" id="CLU_1391004_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF12515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="196" mass="21535" checksum="6ED942A6B2A5AA09" modified="2013-05-01" version="1">MGCLSSARALQRAVATAKAATEKRMPSEAVFGKAKQRRGETSQFRIQLLLQTSAYSGEAASWTAPAEECDIAYRRQRLSRRRCHLYCETPEVCTPSQLSCEDHSQMIVGLTACCMEDAARASVRDEQSHARASTNVLSRPGTVVPRSPFRGADMAKGRSNDIGRHEGGERTVGVNESNEKPFTRNSRAHHDGRPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M3D3A3</accession>
    <name>M3D3A3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_149300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760831.1">
        <property type="nucleotide sequence ID" value="XM_016905473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D3A3"/>
    <dbReference type="GeneID" id="27902610"/>
    <dbReference type="HOGENOM" id="CLU_444933_0_0_1"/>
    <dbReference type="OrthoDB" id="10400496at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF12710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="614" mass="66192" checksum="40880FA093A8E882" modified="2013-05-01" version="1">MTSTFEIAVETSDPARKPLAVGRNPENMIGERLKLPSVKAEAASGRDNFKRTALLERTVLLSDEEDADVSVKPDKPVRSTTGSPTPQTAKRARPADDDVALSGVDLPVEGRLGQPTNRTIAATAVGHGKPKNENTLVNDELRMSSNSSAAQNVFGDFGRFMPNDPSLEGSLEAAKKPKTALMLCGLDEDAPRESDTELLPEQEFPRNPYSVPVQHAPDRLVDAPVSQSLHGSSAMAKESPAASANPTMLQTAGKKPRTTSPPLPFSRTPQPPPLVHSLGEAATSPAAGDTVLPEVMNSPQVTNLPQVTKLGDGTIVCPLPDRGLSRMCIKVTHGVHRARNMQDHIRRVHPEDFVHGMSASEDSIQRMFSGALANPAVAQLIHQLETKQLSKRGSHTGVQDSQNQDIALQKLPAATHDCVDDLVVSGVGSSYPNALKDNLHNSQKGLEQRTAGRVAPPLIPQPHISPSLSQNMAPRRESPAGRPSTAYQPAPPLTRKDSHFSRPRGEPVQRAQQQRNLSSQSLAQMPPSMAPPLTPQQFAQMQSMMLPNPYTSESVPPPALMTNSGAWYHSFPLGHAGQAQIPQQRPHWNPVRVMDGHQPDCRCEECTSGIASYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M3D443</accession>
    <name>M3D443_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peroxin-7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_149275</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the WD repeat peroxin-7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760790.1">
        <property type="nucleotide sequence ID" value="XM_016905454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D443"/>
    <dbReference type="STRING" id="692275.M3D443"/>
    <dbReference type="GeneID" id="27902591"/>
    <dbReference type="eggNOG" id="KOG0277">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046581_1_0_1"/>
    <dbReference type="OMA" id="FAVHWNL"/>
    <dbReference type="OrthoDB" id="273771at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062137">
        <property type="term" value="C:cargo receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005053">
        <property type="term" value="F:peroxisome matrix targeting signal-2 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044536">
        <property type="entry name" value="PEX7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46027">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46027:SF1">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="99"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="249"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF12669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="346" mass="38608" checksum="7DC0E9D3B9B87D39" modified="2013-05-01" version="1">MLEFRTAGFNPYSVKYSPFFDSRLAVSAGANFGLVGNGRLYILQLGAAGIACEKYFETQDCLFDLAWSEQHENQVLTAGGDGSIKLFDIGVGEFPVAAWQEHGREVFAVHWNLIEKSTFLSSSWDGTVKIWTPERKESITTLPVHSCVYSAQYSPHHPQIVTCVSRDSHLRVYDLRQKPSAQNHLTLAIPIHAPPKLPPPGYMQRSPGPTESLTHDWNKYRDSVLAAAGVDGVIRTFDLRTPSGPVNMLTGHDYAVRKLSWSPHLSDVLLSASYDMTCRVWTDGSNVDQAAHGAGIGRELGRMDRHTEFAMGVDWCLFGAEGWCTTCAWDERVLVWDVREYMRPGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M3D4C0</accession>
    <name>M3D4C0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SEPMUDRAFT_149312</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760855.1">
        <property type="nucleotide sequence ID" value="XM_016905481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D4C0"/>
    <dbReference type="STRING" id="692275.M3D4C0"/>
    <dbReference type="GeneID" id="27902618"/>
    <dbReference type="eggNOG" id="ENOG502S87A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090067_1_0_1"/>
    <dbReference type="OMA" id="PGHEHFA"/>
    <dbReference type="OrthoDB" id="432881at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140575">
        <property type="term" value="F:transmembrane monodehydroascorbate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08761">
        <property type="entry name" value="Cyt_b561_CYB561D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045150">
        <property type="entry name" value="CYB561D1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422:SF45">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422">
        <property type="entry name" value="OS05G0565100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="13">
        <location>
            <begin position="32"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMF12734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="238" mass="25495" checksum="A71B6AEDB246A76D" modified="2013-05-01" version="1">MASLRREDTSDEAPLLGERGDASLPGGRPLYHNFVLGTAVVAQAGAWIIAAIVWGSVFSNDLILFSAHPLLNSAGFLLLIQAILVVQPTHTAQQKKEGTYAHAALNDIGVLAAIAGLVVIEYNKISHNGTHFESAHARLGLVAYILVILQVLVGFTQYFTPGLYGGEANAKSLYKYHRVGGYITTVVMLATICAATYTTYNVNVMKIQLWAVVVASVLVVLGVAARVRLSKFGWMAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>M3D4E9</accession>
    <name>M3D4E9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CNH-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_148459</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761206.1">
        <property type="nucleotide sequence ID" value="XM_016904943.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.M3D4E9"/>
    <dbReference type="GeneID" id="27902080"/>
    <dbReference type="eggNOG" id="KOG4305">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001083_2_0_1"/>
    <dbReference type="OMA" id="DMFYHPG"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22541">
        <property type="entry name" value="SP5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041675">
        <property type="entry name" value="PH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057283">
        <property type="entry name" value="RGF3_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052233">
        <property type="entry name" value="Rho-type_GEFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572:SF1">
        <property type="entry name" value="RHO1 GUANINE NUCLEOTIDE EXCHANGE FACTOR TUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15405">
        <property type="entry name" value="PH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23582">
        <property type="entry name" value="WHD_RGF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="5">
        <location>
            <begin position="950"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="1179"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="6">
        <location>
            <begin position="1414"/>
            <end position="1726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="499"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="560"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="728"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="118"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="147"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="171"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="262"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="364"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="419"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="576"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="728"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="742"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="760"/>
            <end position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF13085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1781" mass="196921" checksum="8EA9A9E6172885F7" modified="2013-05-01" version="1">MAYYQAGQYQQQQQQQPPPPPPQSQPPAQQQGYHYPYDEYEQPALNGAYDGRRAPPILPPRDPPHYQYPRQTQTGYSQYPPTGGGGVGGGGGGGGGGGEGGGPVQQPQTAAGYAYQQEPYQSPRSTSFSYVQQPAYSQQYNPQDYVQPAQRRPSQQQSQSTYNPAAYASSLGPQSPYTQQYSPAVYQESTLSSTSGPVDPYAYSPAQYSNSSTFSPHPSQSQFGQSPHVPWSPQTHQPYSPQPPSHQYGYSQSPPPPPPPSHSSYSGYGYSQASAGAPPPAPYPTADFPPHSGPLDSQMPPITMPTAMPSARPDETWLPSPPILGGSDSRYSVSPQRPSEGRPSPPGVTSGPTPPAHAPTRADTLNRHPHERPLPSRPSANAEHHYFQPDPISRTQTGFSSHDEGIDQTQDELFDEVMNMTTGNASLGNRSPSIAISQAPFQPPSTSALSLNTRQDSRASRNGGNQNGRLSPSVTQYVADSYGSDSDVEAAQGLAMMRMAEEEESRRQSSGSQARFNGLSSQRDSRHQQPDASDSSDDLAGVDMTTFGGGYDVHLSYGGDPNQLAAGGELNDTTSHHSQGVSSQQSSMRRSHASQASSRGDYSYRTDSLRHYNPQARVEVGGTGGLSEPTADGRRQSYDEGDEYSFMEGQVPDRFPDEPPDIGFQEASTAYPSRPLPAVPYTEDDISPLTERKALPPLPGPGQPPYTPDAYPGAAAQSLYVPRSTSLLSHSTTPLVTQPLRSKTDAEERRLRQQQARASGYSSEQTTPASGSMLVDLPAIGKRFTAAKLGAPDFRKCEEPWALTSLLKWLLQVTSPEQNTELKEADIKEALVALFTSKVPTMNIADAEALSDRIVEDMYKASVLVSTEEWVKLIPGPFSGVVFQLTRSGCYSPRVHDHVIPNTRCYSHLCQRTLKKINLQAAPSATLASWAEYYKLRKEDLESRDKNEIERQNILHEIVYTEEVFMQNLDVLRVLYRDQLIRVEPSVITPKRKDGFIRAVFGRVDTVRQSNEEHLLPQLKYRQNEQGPWIKGYSDIFRQWTRMAKAAYVNYATDFSRADHLVRTEMERNLEFRNFVERCRADPRSNRLPLDSFLKSPITRLQRYALLLQTVLKTMREETPEKANLQVALQEVKAVATECDLRVAEMQRKIDLQDLESKLVLRPGMQKEVELNLDHFGRSLIHRGDLQRMGSSRFNWLDCHVLLFDHYLVLTKTVVQRVGEGGKIEKYDVSRLPIPMDLLVIDSANDAPVQKSSYVKGITSVREATGRGPSDPMTLARVATNTPMPGLQHVNTGASVNSLHAVTSLGDGKDDKILYPFRVKHLGKDVYTLFAATEQSRRDWCTKIIEAKTKHAAALHAQNAEPFRLRVMADSAFVYDAFGGSGRGVTIKNTPLDRAIKEVELRFKDTGRPGPICRARVNCATSFTTPHPSTQMIAVGTDYGVFVSELDNPRGWTKAINMQRVSQIAVLEEFNLFLLIADKSLLAYHLDVICPTAHNGPTPTHDSARKAPQKLSGSKDVGFFCTGKMKDRTLVFYKKRENLNSVFKVLEPVYQKSSEKKGGHRLAGAGLFKRGNTEFFREYDEFYIPAECIGMSLFQSSLSVSTARGFEVLTLDKKQPWSVPDLNAEHVQNIATHVKDQRALRMLRLSEQEFLLVYTNCAVYINKHGDVSRSVIMRFVGSANSAALYGPYLVLFDDDFVEIRNAMNGRLKQIIAGREVKCLDDGTNWSSSWSGGGGGVGDVKSNGIGRGGGDEGRTLKLVMQHPEVERTQIVVELLLNENMKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M3D5U3</accession>
    <name>M3D5U3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Polyadenylate-binding protein</fullName>
            <shortName evidence="14">PABP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">SEPMUDRAFT_148609</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Binds the poly(A) tail of mRNA. Appears to be an important mediator of the multiple roles of the poly(A) tail in mRNA biogenesis, stability and translation. In the nucleus, involved in both mRNA cleavage and polyadenylation. Is also required for efficient mRNA export to the cytoplasm. Acts in concert with a poly(A)-specific nuclease (PAN) to affect poly(A) tail shortening, which may occur concomitantly with either nucleocytoplasmic mRNA transport or translational initiation. In the cytoplasm, stimulates translation initiation and regulates mRNA decay through translation termination-coupled poly(A) shortening, probably mediated by PAN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the polyadenylate-binding protein type-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761370.1">
        <property type="nucleotide sequence ID" value="XM_016905027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D5U3"/>
    <dbReference type="STRING" id="692275.M3D5U3"/>
    <dbReference type="GeneID" id="27902164"/>
    <dbReference type="eggNOG" id="KOG0123">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_22_4_1"/>
    <dbReference type="OMA" id="QQPGFMP"/>
    <dbReference type="OrthoDB" id="19742at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12378">
        <property type="entry name" value="RRM1_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12379">
        <property type="entry name" value="RRM2_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12380">
        <property type="entry name" value="RRM3_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12381">
        <property type="entry name" value="RRM4_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1900.10:FF:000004">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000003">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000355">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000384">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.10">
        <property type="entry name" value="c-terminal domain of poly(a) binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036053">
        <property type="entry name" value="PABP-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006515">
        <property type="entry name" value="PABP_1234"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002004">
        <property type="entry name" value="PABP_HYD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034364">
        <property type="entry name" value="PABP_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045305">
        <property type="entry name" value="RRM2_I_PABPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01628">
        <property type="entry name" value="PABP-1234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00658">
        <property type="entry name" value="MLLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00517">
        <property type="entry name" value="PolyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63570">
        <property type="entry name" value="PABC (PABP) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51309">
        <property type="entry name" value="PABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 13 14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RRM" evidence="17">
        <location>
            <begin position="53"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="17">
        <location>
            <begin position="141"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="17">
        <location>
            <begin position="234"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="17">
        <location>
            <begin position="337"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="PABC" evidence="18">
        <location>
            <begin position="659"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="368"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="594"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="736"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="306"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="9"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="396"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="665"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="737"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EMF13249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="760" mass="82778" checksum="AA6A7C0DB0F2A63E" modified="2013-05-01" version="1">MSDIQNSTSPAGQVASPPAVAPANNSAAPASSEQSDAPTLTSAAPANANPNSASLYVGELDPSVTEAMLFELFSSIGQVASIRVCRDAVTRRSLGYAYVNYNSANDGERALEELNYTLIKGKPCRIMWSQRDPALRKTGHGNIFIKNLDAAIDNKALHDTFAAFGNILSCKVAQDESGGSRGYGFVHYETAEAANAAIKSVNGMLLNEKKVFVGHHIPKKDRMSKFEEMKANFTNIYVKNIDTETTDDEFRELFEKYGEITSASLARDQEGKVRGFGFVNYIRHEDANKAVDELNDIDFKSQKLYVGRAQKKHEREEELRRQYEAQRQEKSAKYMGVNLYVKNLADDIDDEELRKVFEAYGSITSAKVMRDTTPADQVENAEEEKKEDGENEAESSEEKKEDEKKEDGTEELTKKLDTVTIGGEKKVLGKSKGFGFVCFSNPDEATKAVTELNQKMIHGKPLYVALAQRKEVRKSQLEASIQARNQVRMQQQATAGGIPPQAFMQPQFVLGPNGQPIMIPGSGRGQMPFPQVMPQQGQRGGFQGMPQQGGRGGPAGMPQIPQMPYGFPPQMAGLPQGYGNPAAYAQLMQAAQQAQMSGRGAGRGGPMPGMPMMPGMPGMPPPNMPVGQGFGRGGPAQRSGPMGQQPEQRGRAQNRGPGAPGLDVNSLQQAPPAQQKQMLGEALYPKIQAQQPELAGKITGMLLEMDNEELLGLTTNDDALREKVQEALNVYDEYLKTHSSQAEDQANGVENTEPAGEEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M3D6C2</accession>
    <name>M3D6C2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TFIIF beta subunit HTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_148934</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761851.1">
        <property type="nucleotide sequence ID" value="XM_016905237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D6C2"/>
    <dbReference type="GeneID" id="27902374"/>
    <dbReference type="HOGENOM" id="CLU_590741_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040450">
        <property type="entry name" value="TFIIF_beta_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02270">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TFIIF beta subunit HTH" evidence="2">
        <location>
            <begin position="349"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF13730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="463" mass="51883" checksum="282B644945B79985" modified="2013-05-01" version="1">MTNRPYEMDMPSLPKLMNMEDAASHWTFRASSTDRGRRLDKCDVHNDILYTPHGENRAGCSPSQLSGRDGREEHPVQCNAARDTDPSTEYIDLHHMDGLSEKEEDVRLHLRGGVDDSESCSESDMDTTCGSVVTSTDTCIDLSAPADHDDQEAKDHDLSTRFAGSLQLVYHESYGGWFLQDRQRPLLLELLDRNDAELNRLKRSLAERTDLPVEGPGPDHSCGEGDGCGIHLGSGSAGGFQVAQEVMEERHERSISAQGSVDSRVNTIGLAESTERMEGLSFDLNPSRGRSRVSRWTTDNMPDDIGRQTDIQESKFLGSIGQQTTLRDSNGKGRATSPRYPANSRPFKIPQDQLIVLLRKCFASKPYWTASDLSQSFQQPETHIVDALREIAVFGPWQSDFPQHSWSWKLQSRRNNDGQRSKGKERAESANRIARLPRLCYCRGPDCGYCQSESWTVCDVRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M3D7T0</accession>
    <name>M3D7T0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_149041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762030.1">
        <property type="nucleotide sequence ID" value="XM_016905302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D7T0"/>
    <dbReference type="GeneID" id="27902439"/>
    <dbReference type="eggNOG" id="ENOG502S0VB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068952_0_0_1"/>
    <dbReference type="OMA" id="GCFLQFQ"/>
    <dbReference type="OrthoDB" id="3926209at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF3">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF13909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="273" mass="30417" checksum="006D9153915AE0E3" modified="2013-05-01" version="1">MADTEGEIMVEDDTAVDETMGMAENVETVVDETAPGGLEDIEPTIPPRTTFLDYMRSPIVELIIGSGNTQSTLYAHQGLLESSPFFAEACAHFSDSASRRRIELQQDDEAAIASVLEYLYKTDYFPSLQGSTNLEYDPTVPSPDNDGIGLLRHARVYTLAQKFGLPQLAALAHKKIHLTQSTAKGEIAYARFVYKETSVDDESIRKPVAAFWATRSHVLRHEAEHEFKRMCLEFPQFGFDVLSLVLDAQEKRSKRAEDSTAGPAGRKRQRTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M3D7Y6</accession>
    <name>M3D7Y6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_147848</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF13974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762095.1">
        <property type="nucleotide sequence ID" value="XM_016904549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D7Y6"/>
    <dbReference type="STRING" id="692275.M3D7Y6"/>
    <dbReference type="GeneID" id="27901686"/>
    <dbReference type="eggNOG" id="KOG4120">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042829_1_0_1"/>
    <dbReference type="OMA" id="WRYGRSI"/>
    <dbReference type="OrthoDB" id="565731at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008263">
        <property type="term" value="F:pyrimidine-specific mismatch base pair DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10028">
        <property type="entry name" value="UDG-F2_TDG_MUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="entry name" value="Uracil-DNA glycosylase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015637">
        <property type="entry name" value="MUG/TDG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12159">
        <property type="entry name" value="G/T AND G/U MISMATCH-SPECIFIC DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12159:SF9">
        <property type="entry name" value="G_T MISMATCH-SPECIFIC THYMINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="Uracil-DNA glycosylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uracil-DNA glycosylase-like" evidence="4">
        <location>
            <begin position="2"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF13974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="158" mass="18167" checksum="414C6FBEEA08CC46" modified="2013-05-01" version="1">MFWKLLHSSGCTDIRLRPEQDVDLPRLYSMGNTNIVARPSRHAAELSKAESAAGTPVLEEKIRAFRPEAVCIVGKGIWESIWRWRHQRAIRKDEFQYGWQKESERIGKTADWPGAAVFVATATSGLAANTKPHEKEAIWLPFGQWVKRRRQERAESRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M3D8F5</accession>
    <name>M3D8F5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_148116</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762521.1">
        <property type="nucleotide sequence ID" value="XM_016904715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D8F5"/>
    <dbReference type="STRING" id="692275.M3D8F5"/>
    <dbReference type="GeneID" id="27901852"/>
    <dbReference type="eggNOG" id="ENOG502RZF1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026455_2_0_1"/>
    <dbReference type="OMA" id="ININRWT"/>
    <dbReference type="OrthoDB" id="4179406at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF14400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="574" mass="64509" checksum="E978A5BF57914994" modified="2013-05-01" version="1">MTRSRRARPDDLTESWDNLSGSEPSDDIYDEETERDEVGSVYRSSRTASSMDARSLRPIDDDENETPRRRTLRSSIEPELVMPSSPDARPHHTKDGRKRDATPRFRLNDRSNTSDAGQIRRVTRAETPRTRLAERSMTSDAGRYRGSKLGQHDEADYDEPDADEPQRGADYTAMIWKGIVRPLLSYVTDVVGLVLHNLKPLLGWAVLAYLLAAVLVFGSGFLNNTINNALTPICRLPFTGGLSFCPSRNAPELQGQAQFGQLVQAQNAFEDVLQISTVGANLPADMKRSEASIRDLKNIVQYSNLPSRNELVFEFSGFVETARQASGDLSRFNSRIGRAVDHILATNKWTLNVIDGVTEKDAQRGSIAKFFSNNFNILAPFQPISFSRDLLLDQYLRHTGAVEEQIMSLIDEALALRDILDNLDNRLDVIAGISTRDGIKLDSSKDELFAFLWTKLGGNRKDIKKLQSQIELLNNVSEYRRLAWGHVTATLLKLQEIQHSLEDLRERVALPDTIGTHKVPLEVHIESINLGIERLEKQRDASRQVAAQNYERIVGKVESGEKKMLGSGKQEREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M3D8U5</accession>
    <name>M3D8U5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_63032</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762681.1">
        <property type="nucleotide sequence ID" value="XM_016909622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D8U5"/>
    <dbReference type="STRING" id="692275.M3D8U5"/>
    <dbReference type="GeneID" id="27906759"/>
    <dbReference type="eggNOG" id="KOG1361">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013294_0_1_1"/>
    <dbReference type="OMA" id="VFYFRAW"/>
    <dbReference type="OrthoDB" id="5561659at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240">
        <property type="entry name" value="DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240:SF8">
        <property type="entry name" value="PROTEIN ARTEMIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23023">
        <property type="entry name" value="Anti-Pycsar_Apyc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="533"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="626"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="533"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="545"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF14560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="648" mass="72893" checksum="C6733B40B736C118" modified="2013-05-01" version="1">MSTFDGVVAEFPDIRIDYFRQSSSQNARPALANFLSHVHSDHLQGLESCRGPFIWCTTATREILLRLEKYPHRMNFATGILESRQQTYKHLRKLLKPIPLETPTDIELVPGRSIRVTLLDANHCVGACMFLIEGDGKAILYTGDIRAEPWWVNALIRNPVMLPYACNGKALPQKQLDTIYLDTTFANKGDRYRHFPTKAEGIDELLQKVAQYPRETEFYIDAWTFGYEDVWQAVSVFLRSQIHVDDYRYGLYKSLCNGPEPKAPEAYKLIGARIGNEDREGCLSTRYRRIHSCERGTGCSIFNNDFVRITPIISRHNRMEMVEAGAGGGHGDLNQQHELKIDDGVVYQELMSLCMEKLHDQPNISSSVIQMLKDATSNGGAAISLSLSDFSSEASTHSVARGADEDALDEVERNLPLERLVFLLAKRATKIKARSVAARTDVALPPHSGLPKQITFPYSRHASYGELCILVKALMPRNIYPCTVDKSNWGPEHTMSYLFGHLYPTSQAFGHDTMMLRQYTVDMDNADSLGEQTQYQEMETQRSASAEENHTRAHDTQASAPRSSPPAEQQMRKHRSNDQDEPAPAKRWKRSLEHFSSSSAAKTGLEELTSDQMREAVQRMAYNAALGNGGGEWSLVSVDGHGTKEEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M3D8V8</accession>
    <name>M3D8V8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein DOM34 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_148246</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the Dom34-Hbs1 complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway (PubMed:20890290). In the Dom34-Hbs1 complex, dom34 recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel. Following ribosome-binding, the Dom34-Hbs1 complex promotes the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the eukaryotic release factor 1 family. Pelota subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762696.1">
        <property type="nucleotide sequence ID" value="XM_016904799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D8V8"/>
    <dbReference type="STRING" id="692275.M3D8V8"/>
    <dbReference type="GeneID" id="27901936"/>
    <dbReference type="eggNOG" id="KOG2869">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023334_3_1_1"/>
    <dbReference type="OMA" id="DDLWHLK"/>
    <dbReference type="OrthoDB" id="10249111at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990533">
        <property type="term" value="C:Dom34-Hbs1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070651">
        <property type="term" value="P:nonfunctional rRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070966">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, no-go decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070481">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, non-stop decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071025">
        <property type="term" value="P:RNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.60:FF:000004">
        <property type="entry name" value="Protein DOM34 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.870:FF:000001">
        <property type="entry name" value="Protein pelota homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000008">
        <property type="entry name" value="Protein pelota homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="entry name" value="eRF1 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.870">
        <property type="entry name" value="Pelota, domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_Pelota-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038069">
        <property type="entry name" value="Pelota/DOM34_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058547">
        <property type="entry name" value="Pelota_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004405">
        <property type="entry name" value="TF_pelota"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00111">
        <property type="entry name" value="pelota"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853">
        <property type="entry name" value="PELOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853:SF0">
        <property type="entry name" value="PROTEIN PELOTA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26356">
        <property type="entry name" value="Pelota_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159065">
        <property type="entry name" value="Dom34/Pelota N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0469">Meiosis</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1/Pelota-like N-terminal" evidence="11">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF14575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="415" mass="45950" checksum="9C1B7D935B426E69" modified="2013-05-01" version="1">MRLIKQNIIQKDGSGTATLLPEEPEDMWHCYNLIRPSDKLRASAIRKVVTEGAAGSTRNERVHMTLTITVTKLDFDPQAGQLHVSGQVAEENKWVKLNSFHTLDLELQRNFTLEKADGWDSVALETLKEAIDQDKRAVLWAVVMADGLANICLITEHQTILRQKIEVSLPKKRAGSSDHEKSLQRFFQITYDSLLRQIDLTNPIPLLLASPGFTASLFHSFIKTQASTTANKQLAQLIPKITIAHSASGHLHALGEVLASPAVTSKLSDTKFARETQLMDKFLEMMRKDDQRAWYGPRECATAVERGAVGKGGGVLLISNSLFRSQDIKTRKKWVGVVDEVKAQGGEVRVLSSMHESGKRLEGLGSIAAILTFPIEDLDDGLDDFEGGYDLDDDDEVNGTGVEGKHDVHEDVDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M3D9B3</accession>
    <name>M3D9B3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amidohydrolase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_148171</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762590.1">
        <property type="nucleotide sequence ID" value="XM_016904754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D9B3"/>
    <dbReference type="STRING" id="692275.M3D9B3"/>
    <dbReference type="GeneID" id="27901891"/>
    <dbReference type="eggNOG" id="KOG4245">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039329_5_1_1"/>
    <dbReference type="OMA" id="TWASEDM"/>
    <dbReference type="OrthoDB" id="432010at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000099">
        <property type="entry name" value="Amidohydrolase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF30">
        <property type="entry name" value="AMIDOHYDROLASE-RELATED DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="4">
        <location>
            <begin position="73"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF14469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="324" mass="36586" checksum="153A63D16BF62EF8" modified="2013-05-01" version="1">MAPPPLIALEEHFLSTAILDAYDDQYREQYKAIPGVKAKLGDLETVRLSEMDKGGIRLQVVSHACIPGAPNPELCRKGNDQLAAAIRKNPDRLAGLAVLPMASPKESAIELERCVKELGFPGALIDNHADGKYFDGDEYDVMWQKAEELDVAVYLHPTWPTEDMMRSYTGNFTTGATMSMSASGWGWHTETGLHVLRLYAAGLFDKFPKLKIIIGHFGEMLPFMLHRVSKLSSRWGEQHRKFLQVWKENIWLTTSGVWSLDPLKCILGNTNIDHILFSVDYPFETNENGLKWMVELEQSGLVSREDLEKIAYKNAEKLLKIRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M3DB44</accession>
    <name>M3DB44_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Glutamate synthase [NADH]</fullName>
            <ecNumber evidence="19">1.4.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">SEPMUDRAFT_147049</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27 28">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Forms L-glutamate from L-glutamine and 2-oxoglutarate. Represents an alternative pathway to L-glutamate dehydrogenase for the biosynthesis of L-glutamate. Participates with glutamine synthetase in ammonia assimilation processes. The enzyme is specific for NADH, L-glutamine and 2-oxoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>2 L-glutamate + NAD(+) = L-glutamine + 2-oxoglutarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="1.4.1.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="24">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="24">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-glutamate biosynthesis via GLT pathway; L-glutamate from 2-oxoglutarate and L-glutamine (NAD(+) route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Energy metabolism; nitrogen metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nitrogen metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glutamate synthase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.14" evidence="19"/>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763190.1">
        <property type="nucleotide sequence ID" value="XM_016904053.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.M3DB44"/>
    <dbReference type="GeneID" id="27901190"/>
    <dbReference type="eggNOG" id="KOG0399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_8_2_1"/>
    <dbReference type="OMA" id="WDGPAAM"/>
    <dbReference type="OrthoDB" id="4327079at2759"/>
    <dbReference type="UniPathway" id="UPA00045"/>
    <dbReference type="UniPathway" id="UPA00634">
        <property type="reaction ID" value="UER00690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016040">
        <property type="term" value="F:glutamate synthase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016639">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019676">
        <property type="term" value="P:ammonia assimilation cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097054">
        <property type="term" value="P:L-glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00982">
        <property type="entry name" value="gltB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00713">
        <property type="entry name" value="GltS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02808">
        <property type="entry name" value="GltS_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000160">
        <property type="entry name" value="Glutamate synthase (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1060.10:FF:000006">
        <property type="entry name" value="Glutamate synthase (NADPH/NADH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000031">
        <property type="entry name" value="Glutamate synthase 1 [NADH]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000017">
        <property type="entry name" value="Glutamate synthase [NADH], amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000113">
        <property type="entry name" value="Glutamate synthase [NADH], amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000022">
        <property type="entry name" value="Glutamate synthase [NADH], amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.60:FF:000001">
        <property type="entry name" value="Glutamate synthase, large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000001">
        <property type="entry name" value="Glutamate synthase, large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.60">
        <property type="entry name" value="Glutamate synthase, alpha subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002489">
        <property type="entry name" value="Glu_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036485">
        <property type="entry name" value="Glu_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006982">
        <property type="entry name" value="Glu_synth_centr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012220">
        <property type="entry name" value="Glu_synth_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002932">
        <property type="entry name" value="Glu_synthdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006005">
        <property type="entry name" value="Glut_synth_ssu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051394">
        <property type="entry name" value="Glutamate_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01317">
        <property type="entry name" value="GOGAT_sm_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008730">
        <property type="entry name" value="PRK11750.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43100">
        <property type="entry name" value="GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43100:SF1">
        <property type="entry name" value="GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00310">
        <property type="entry name" value="GATase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04898">
        <property type="entry name" value="Glu_syn_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01645">
        <property type="entry name" value="Glu_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01493">
        <property type="entry name" value="GXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000187">
        <property type="entry name" value="GOGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69336">
        <property type="entry name" value="Alpha subunit of glutamate synthase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18 24" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0274">FAD</keyword>
    <keyword evidence="9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0288">FMN</keyword>
    <keyword evidence="17" id="KW-0314">Glutamate biosynthesis</keyword>
    <keyword evidence="13" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="15" id="KW-0408">Iron</keyword>
    <keyword evidence="16 24" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="26">
        <location>
            <begin position="58"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="23">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1189"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1195"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1200"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00024383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00057049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00068518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR000187-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR000187-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="EMF15069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="2138" mass="235635" checksum="325512CB16ABEBDA" modified="2013-05-01" version="1">MGRVSFADDVKPPADDHEIEQEPVNVYPYQNTPENKSWAGALPLKQGLYDPELEKDACGVGFAAHIKGKPSHKIVTDARNLLCNMTHRGAVGSDARDGDGAGVMTSIPHKFFIKNFEREQGIQLPELGKYAVGNVFFKPEEEALKDTLAQFEDIADGLDLRVLGWREVPKDSTLLGPAASSREPIILQPFVVLKSVYGSGKELPADFDEKYDEQTFERQLYVLRKRATHVIGLHNWFYICSLSNKNIVYKGQLSPVQVYSYYHDLVNVDYEGHFALVHSRFSTNTFPSWDRAQPLRWAAHNGEINTLRGNKNWMRAREGVLKSEFFGDELESLYPIIEDGGSDSAAFDNVLELLMINGVLSLPEAVMLMVPEAWQGNDTIDGAKQAFYEWAACMMEPWDGPALFTFSDGRYCGANLDRNGLRPCRYYVLDDDRIICASEVGTIAIDPTTVVQKGRLQPGRMLLVDTQAGRIIDDAELKETVSGRQDFRSWLDAQLLVLPDIHKKLLDNGTDLSFKLTDTTVNEDPRLKAFGYSLEQVSLLLAPMAADSKEALGSMGNDAPLACLAQQPRLLYEYFRQLFAQVTNPPIDPIREAVVMSLGSYVGPQGNLLEINKEQCHRLYLPSPMLSVEEFNALNQVSTLHSDWSVATIDITFEKKEGLAGYYDALDRICEAAGEAIENGDKVIILSDRKTSSERIAVSALLATGMVHHHLVRNRWRAQAALVVETAEAREVHHMCVLVGYGADAICPYLAIECILKLDREGLIRKKLSPEQLIDNYKHSCDGGILKVMSKMGISTLQSYKGAQIFEALGIDDSVVDRCFTGTATRIKGMTFELIAQDAFALHEKGFPSRDIREIPGLAETGEYHWRDGGEPHVNDPVSIANIQDAVRNKNDKSYEAYSRSEYEQIKNCTLRGLLDFDFDATSSIPIEQVEPWTEIVRRFVTGAMSYGSISMESHSTLAVAMNRLGGKSNTGEGGEDPERSLPMENGDTMRSAIKQIASGRFGVTSNYLADADELQIKMAQGAKPGEGGELPGHKVSGPIAKTRHSTPGVGLISPPPHHDIYSIEDLKQLIYDLKCSNPRSRVSVKLVSETGVGIVASGVAKAKADHILISGHDGGTGASRWTGIKYAGLPWELGLAETHQTLVLNDLRGRVVVQTDGQLRTGRDVALACLLGAEEFGFATTPLIAMGCIMMRKCHLNTCPVGIATQDPELRKKFKGTPEHVINFFYYVSNELRAVMAKLGFRTVNEMVGHTEMLKVREDLRNAKTENIDLSLILTPAHTLRSGVATYNVRKQDHKLHTRLDNKLISESELALEKGLPCRIECDIVNTDRALGATLSYHISKRYGEKGLPNDTIHANIRGSAGQSFGAFLAPGVTLELEGDANDYVGKGLSGGRLIVYPPRSAVFKAEENVIIGNVCLYGATAGTCFFRGVAAERFAVRNSGVTTVVEGVGDHGCEYMTGGRVVVLGSTGRNFAAGMSGGIAYVLDLHKDFEGKVNQEMVELSGLEDPHEIAFLRGLIEDHHHYTGSELAARILLDFNRALPHFVKVLPTDYKRVMEEEAQKEAAAKKAAYPLPILPGSAVRNLHETSREHEHAAEKKKASLGDLEESISDAAREKKRSLVLDKTKGFMKYQRRAEKYRPAKTRTRDWAELSTRLNEDELKYQTARCMDCGVPFCQSDTGCPISNIIPKWNELVFQGQWKDALNRLLMTNNFPEFTGRVCPAPCEGACVLGINEDPVGIKSVECAIIDRGFEMGWMVPSPPKVRSGKTVAIIGSGPAGLACADQLNKAGHSVTVYERSDRVGGLLMYGIPNMKLDKNVVQRRVDFLAAEGIEFKTGVFVGEGDITFESLRKSNDAVVMATGSTLARDLKIPGRDLNGIHFAMQFLHKNTKSLLDSELADNAYISAKGKNVIVIGGGDTGNDCIGTSVRHGAKSVVNFELLPQPPAQRANDNPWPQWPRIYRVDYGHTEVKTHMGRDPREFCIMSKDFVDDGSGNVKGVNIKRLEWTKNSNGGWDMKEIEGSEQFFPAELILISMGFLSPEDKVFEGQIELDGRKNIKTPPGHYNTNVEGVFAAGDCRRGQSLIVWGINEGRMCARDVDSYLTGIGTMLPVTGGIVKRPPYELLSKHNDAPKELITAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M3DB60</accession>
    <name>M3DB60_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_147226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763426.1">
        <property type="nucleotide sequence ID" value="XM_016904158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DB60"/>
    <dbReference type="STRING" id="692275.M3DB60"/>
    <dbReference type="GeneID" id="27901295"/>
    <dbReference type="eggNOG" id="ENOG502S38Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023951_0_0_1"/>
    <dbReference type="OMA" id="IQMQTYR"/>
    <dbReference type="OrthoDB" id="4181307at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034443">
        <property type="entry name" value="PB1A10.08"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42051">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED PROTEIN PB1A10.08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42051:SF1">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED PROTEIN PB1A10.08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF15305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="473" mass="51917" checksum="9E61812691C84623" modified="2013-05-01" version="1">MLVPSSFKYSSAAMDTPSQRGPRPPVLKLPYRERQHSPPPRSVSSRPTTEPVSIPSPKVTNVAQSGRTRSGSHYTIMSAERSASVNIARREPSAYGPNGLPPAVATLLAVTAIPPRRPNRYRTKPGSHRRISIEELINDWKSDDTFKQSVGSPGSVALNTLLEDDDDMGPESHDATEPGYLNARSASSDSMPSLDSDSQSVLSIGSVSTPGSLRSRQSFSTLRKDKSRSLAASQDCAFDHPLITRVDDDDHDELLFSMPKHTLATKKSKTSFKSNLTASLQTLKEAAVNSISSLRRTGSMPSLSRAAASPMDDMLWSHPFLFPRFSSETRPAYDGTPTPAQRRYLNPMPLTFEEQEAPFQEALHAPFLAEAVDQAPTIQLQTYNRGRKRPSPKRSAPSPGSEAGRALLGQVAGRQRDVRENSNFLRVVVLEMNMRREGKIEQGKAKIWLPPRQSSASPVQQGRVPQRWVGESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M3DE10</accession>
    <name>M3DE10_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_147692</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764101.1">
        <property type="nucleotide sequence ID" value="XM_016904467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DE10"/>
    <dbReference type="STRING" id="692275.M3DE10"/>
    <dbReference type="GeneID" id="27901604"/>
    <dbReference type="eggNOG" id="ENOG502T1XE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024064_1_0_1"/>
    <dbReference type="OMA" id="KMHWSPR"/>
    <dbReference type="OrthoDB" id="5311681at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="59"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF15980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="598" mass="67476" checksum="F3F45E627C2F7778" modified="2013-05-01" version="1">MKRARSPDAPPKRADMGAPMRHSSMTGSYRKVPPMLVYTSPAASTAPPFGGGGQRPATTLPLNLVAHIVSYLDDVGDIARVTRSCRLLYYMTLPQLYRRVTLHSYGEMRYVNGRPEGFGSGSPFMMGLNGLTTRGHAALVEEFRLWGKWQETGVEDFAKGRIPDSSMMLNIILRAATDKMTKLKSFCWELECKPLKTLYLGLASHTNLTSLTLKFPSVRVPRPSVLVPAMTNLRVFKALDIDPLCYPDDISLLMLQSKKLEDVRLHFSPRMRAEAESIINFNTYFGRCHKANYRLNIKHFALQNWFGPNVLGLDAIFDPDVCKSVTFLDSFVGNDPRTVFVDDTWKDVPPDLAVTFERVRCNELSLQHIKVIQNAKVGLKYVYLPSNAHRQRTGFTPSSNGNSASPHTPSVETTPLTPYDPLKDADWVALGKEYLHVLGRKHGATLKHLLLSDSWAVTQEDFADLISHCPQLEQLGIAVDSADHTAFRLLTPSLVNLRCLRILDNEYLRQHFAQWTHEQRMWVMSREMGKRPPRHLEFICLADFCYKIGGPTEILLEDGSVEAGREITLVDKSEAMKYEIWHLDVVDLTVDPIAPFTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M3DE93</accession>
    <name>M3DE93_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7605 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_115151</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF16100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764221.1">
        <property type="nucleotide sequence ID" value="XM_016901134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DE93"/>
    <dbReference type="STRING" id="692275.M3DE93"/>
    <dbReference type="GeneID" id="27898271"/>
    <dbReference type="eggNOG" id="ENOG502SJYS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_313557_0_0_1"/>
    <dbReference type="OMA" id="TELCKEM"/>
    <dbReference type="OrthoDB" id="3598281at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056024">
        <property type="entry name" value="DUF7605"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36681">
        <property type="entry name" value="NUCLEAR GTPASE, GERMINAL CENTER-ASSOCIATED, TANDEM DUPLICATE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36681:SF3">
        <property type="entry name" value="NUCLEAR GTPASE, GERMINAL CENTER-ASSOCIATED, TANDEM DUPLICATE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24564">
        <property type="entry name" value="DUF7605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7605" evidence="2">
        <location>
            <begin position="633"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="896"/>
            <end position="934"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF16100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="934" mass="105686" checksum="E00F82F7B436F5C2" modified="2013-05-01" version="1">MSKRASDGAKIPLLDLIDGLNQSIKSEDPPSGTYSKILFDRDEVEGLSIRAPAYDSKFQLVLDSLNELTTDLLKAIPEQHHQHAIFKHLVKQLKRAATCPASRKRRINVIGKSGAGKSTLMNCLMGLVGFAKADIATGCTTIPTSHEAPFADQILDFAAHIQYFSIKTIRQRLTSMWHDYYDFHFEENKSDWTEDDRQDARQSAQTALDALCSLFRSHDAFSTDLKAKQTLKALRFEHIDNIIGPWVTWCRDVLPTPGQEGDDLSDLDDRIPVLKFETSTQQELRAQLDIYAYPDTRRTSFWPLVDTIRVGLRGIRILSYVTLVDWPGAGDTNDLRGKASTGRVADCDEVWIVSDPNRICTDPAIWRSISRFAATHPCSIICTKVDEKCDDFTDMDKIRKDGFEMGEIDDLRASEKDTSEHVETYKNTLQEWTEIIGLGFQTLPDNKRLKVSQEDVAQRQARLPEVQNELFVSQRKLSDIQRDRRTRVVEIRNAWLRTQIHSQLKRDISAAYHVDVFFASSRHYLAHKRLETVSGALLPLADTGIPGLRQHILRQASPGIVTSVRHYITGEVSRVLEGVGVAAAPKDLADCYAVLEHIKKKHNLGIQAQQSYMEATDDGSSECFIRGIEDKRQRLAIAAVKVVEGLREWHAMSLKAFIAKDGDFATQRQKAQRWNEKFAGKLGDIILRSWNSFAATKVESTKTLESFLKAELRDIIQLSSTERGASKRLADREGQFRVFVETQVQQLTNKCDNAAEMYAVKMRGIKVDAIKTGCRLSKSYFDYAMEPTYAEARGIRGRGFIKKANDHFEAHMKNNGKKSPFIFAAFLLKDAADSAAEEQADAAVQAFCECLDDIYQWLDGVFVEHGDVRGIWAILLDLEKAHKLGQRKVLECEHRLKMVDEEYGKEEENAKRLKRNAADRERNAKARLAKLELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M3DF80</accession>
    <name>M3DF80_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_37766</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF16179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764300.1">
        <property type="nucleotide sequence ID" value="XM_016908679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DF80"/>
    <dbReference type="STRING" id="692275.M3DF80"/>
    <dbReference type="GeneID" id="27905816"/>
    <dbReference type="eggNOG" id="KOG0591">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_714892_0_0_1"/>
    <dbReference type="OMA" id="TEACLLM"/>
    <dbReference type="OrthoDB" id="310217at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF13">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="23"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF16179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="387" mass="42962" checksum="A0ACBDD38CAEF40F" modified="2013-05-01" version="1" fragment="single">AREDARKKFGVNDSPAGDDSLTWHYCGEIGSGTFGTAHLWVTTNGADNITARVVIKNSWVSDPDRWGSVKCWHGDPRDAANRTPVEIYAMRVMRGRPGSDRVVGYNASSVDDARMAYRIIMPYYAHGSLNAMVKEYQLPANAQSNIPEPFIWSVFEAMTEACLLMENGTTLSTATPPADWHQIVHKDIKLENIWFDTCGPVWPSFPRPVLGDFGMCVLTQENDMMNPSHYADDMGTRGYMAPEQVHFISRKTQEKQLLSRLQGWTNVYGVGRLIQCLMKKTTGADGPKWDKGYEDLGEIFTAAEKLAYSQELRSLAIKCTRYTPRKRITARRLKGKILRRTGGAAAGVGKPDHAGGRRTTAAPSGFLLGWETTDQYALGLAFNPTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2023-02-22" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1QD64</accession>
    <name>N1QD64_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_110710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757306.1">
        <property type="nucleotide sequence ID" value="XM_016900859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QD64"/>
    <dbReference type="GeneID" id="27897996"/>
    <dbReference type="HOGENOM" id="CLU_1556233_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110649" evidence="1">
        <location>
            <begin position="23"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="172" mass="18124" checksum="EC46E3FC4EDCB572" modified="2013-06-26" version="1">MVWITKRAAAMIALSFFLPAHAVPHPLDSAHSPKTPSLAQAKNFAGMTPGNSNQLMKAKDSLDSLDTVDEEDHAPPPAQKYCLCVDPGQSQADTTATNKVCGGYGNNINNSRKGPTGATFTSCENIYEESFTAFGNSCIMFYGHASPGNGKEGAICCTTTGTEAGGQCNLYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1QEA4</accession>
    <name>N1QEA4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Mitochondrial import inner membrane translocase subunit Tim21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_22548</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to keep the TOM and the TIM23 complexes in close contact. At some point, it is released from the TOM23 complex to allow protein translocation into the mitochondrial matrix.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the TIM21 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758806.1">
        <property type="nucleotide sequence ID" value="XM_016908358.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QEA4"/>
    <dbReference type="STRING" id="692275.N1QEA4"/>
    <dbReference type="GeneID" id="27905495"/>
    <dbReference type="eggNOG" id="KOG4836">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089407_0_0_1"/>
    <dbReference type="OMA" id="HFHVEGP"/>
    <dbReference type="OrthoDB" id="436405at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.320:FF:000002">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.320">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit Tim21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013261">
        <property type="entry name" value="Tim21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038552">
        <property type="entry name" value="Tim21_IMS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032:SF6">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08294">
        <property type="entry name" value="TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="11" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF10685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="189" mass="21118" checksum="E5BC37E55C59EDF5" modified="2013-06-26" version="1" fragment="single">RRAVTIVNDTGAVPWKELSLGEKAARTTQQSFNLGIVLLGVGLTGAVATVLWLEVFSTDSKTAYFNRAADRIRADAQCRKLLTGDERASKRDIEAHGEPSWSRWARNRVIASRLETDRAGVEHLHMHFYVSGKQANGTVQLHMSRRPGEDFQYQLLALDVPGEQRVYLENASALQQAKAGKLFGINWNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>N1QEZ2</accession>
    <name>N1QEZ2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Heat shock protein 60, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_149622</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759833.1">
        <property type="nucleotide sequence ID" value="XM_016905669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QEZ2"/>
    <dbReference type="STRING" id="692275.N1QEZ2"/>
    <dbReference type="GeneID" id="27902806"/>
    <dbReference type="eggNOG" id="KOG0356">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016503_3_0_1"/>
    <dbReference type="OMA" id="TDTDKME"/>
    <dbReference type="OrthoDB" id="1733909at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:DNA replication origin binding"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:'de novo' protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045041">
        <property type="term" value="P:protein import into mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000001">
        <property type="entry name" value="60 kDa chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00600">
        <property type="entry name" value="CH60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000592">
        <property type="entry name" value="PRK00013.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009487">
        <property type="entry name" value="PRK12849.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009488">
        <property type="entry name" value="PRK12850.1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PRK12851.1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="60 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CHAPERONINS_CPN60"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF11712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="580" mass="61048" checksum="0DF99FDAEBFF2DAC" modified="2013-06-26" version="1">MQRVLSSTPRTVARQTRIRPASLVQQRFAHKELKFGVEGRAALLSGVETLAKAVATTLGPKGRNVLIESSYGSPKITKDGVTVAKAVQLKDKFENLGAKLLQDVASKTNEVAGDGTTTATVLAHAIFSETVKNVAAGCNPMDLRRGTQAAVEAVIDYLRTNKRDITTSAEISQVATISANGDTHIGGLLATAMEKVGKEGVITVKEGKTIEDELEVTEGMKFDRGFISPYFITDTKSQKVEFEKPLILLSEKKISAVQDIVPALEASQQLRRPLVIIAEDIDGEALAVCILNKLRGQLQVAAVKAPGFGDNRKSILGDIAVLTNGTVFTDELDIKLEKATPDMLGSTGSITITKEDTVILNGEGTKDMVTNRCEQIRGVMADPTTSEYEKEKLQERLAKLSGGVAVIKVGGASEVEVGEKKDRMVDALNATRAAVEEGILPGGGTALLKAAANALGSVKTTNFDQQLGVSIVKNAITRPARSIVENAGLEGSVIVGKLMDEFGKDFNKGFDSAKGEYTDMIAAGILDPFKVVRTGLSDASGVASLLGTTEVAIVEAPEDKGPAGMPGGMGGMGGMGGGMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>N1QF46</accession>
    <name>N1QF46_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_126249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016902049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QF46"/>
    <dbReference type="GeneID" id="27899186"/>
    <dbReference type="eggNOG" id="ENOG502R1BS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2279246_0_0_1"/>
    <dbReference type="OMA" id="RTSWEDC"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF11838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="102" mass="10891" checksum="181A5992AD9B1682" modified="2013-06-26" version="1">MAVKISQSALKKSSAPPHLSRQDSYSAQRDQTASSRQVNATLVLASVASRASSPGRKSPTSPLPSPGVNGGGRRTSWEDCKVKRDGYVSFPDFDDPQASQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFP4</accession>
    <name>N1QFP4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BAR-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_149845</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760183.1">
        <property type="nucleotide sequence ID" value="XM_016905807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QFP4"/>
    <dbReference type="STRING" id="692275.N1QFP4"/>
    <dbReference type="GeneID" id="27902944"/>
    <dbReference type="eggNOG" id="KOG1118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034817_1_0_1"/>
    <dbReference type="OMA" id="KSMTSYV"/>
    <dbReference type="OrthoDB" id="14167at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAR" evidence="3">
        <location>
            <begin position="15"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="233"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="126"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="233"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="312"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="431"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF12062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="440" mass="49781" checksum="44A6B701929ECD67" modified="2013-06-26" version="1">MNINKKFDRMKQWGKERMGGEKLSDTTEEFKSLEQEMTLRQNGMSRLKKSADVYVQHTAKREKYQEKEQQLPVAYFGSTMVAHGDDFEPDSEFGQCLSMLGRANERIARMQETYCANATSSWLESLERSLVQMKEYEKARKQLENRRLAYDTASQKMQKSKKEDFRMEEELRNQKMKYEESSEDVYRRMLDIKEAEVDSVQDLSSFLEAELTYYDRCREVLLQLKRDWPASTQLSRSNNASPVNGRGSGPLERRSTRSRASSVNDRFNTIDEDDPLPAPRRPTISSRLPSGANSPMKELPGFDIPTRPGIRSASSTGFEGPMSSSYNARAESPAHVPRITRAPTEPSTLLGARSNLRITKSREGSQPPTSSHEGVFADDQVENGGVSRYDELQRTTSYGPDGMAKKAPPPPPPSRASKPKPPPPPMKRSALSTSEVPSYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFT1</accession>
    <name>N1QFT1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_120234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757499.1">
        <property type="nucleotide sequence ID" value="XM_016901583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QFT1"/>
    <dbReference type="STRING" id="692275.N1QFT1"/>
    <dbReference type="GeneID" id="27898720"/>
    <dbReference type="eggNOG" id="ENOG502SRWN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_279797_0_0_1"/>
    <dbReference type="OMA" id="DFFPRNT"/>
    <dbReference type="OrthoDB" id="30417at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="527"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="612"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="679"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="752"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1003"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="687"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="753"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="789"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1019"/>
            <end position="1036"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1125" mass="121334" checksum="8DA9E8ABAFD6D12B" modified="2013-06-26" version="1">MQNEILDAQERASELAWRAEGNMNDLKFLLEAGGTWSNGEVTITDYRLIEHVLKISRSFAARSYRGRQSTASSLRVPSNASHNENSSVSSRGAFLPPDSHVTQPEVLSDIVPNGQVLRFRPRRSPTPSLKRAAVEAIVKSHGSPNHMRVTAGGRIVPSEQSPLCQPRYGYSAIKMNGRLIKFAPNGRFGNRPQELEHATDQNGQVVEDMHGNYFQIVNHKILPLQTRPDGSMELHMAASNINMSQQQALPPHAPSMPPFRPAGQSAEPIVKNSVVVPEPSPAMQIKVLKAEHKRYEDEMRQLSQTEAVRGREMSQHDRNRLITRRRQLVTEADQVRRRIKELESRPPQDAPTSPRAMQGKHSMPTAGRGRGNFQPMLQGPLTNVGAPQKYGPSLNGPSPSFVPQFGATISPEEGFTNAWAVPPNGIFMPPPPFDGAMAGPLPNMMPLTGALAPVHSEIPQCDGARSLADHGVDSPDRSRAISIKAPEGKSGLRSVLNPMSPVYKPSMADDQKMAAPAAQRRVVTPLSPMQKPAAPVPSAVNSSIATDETVSPSKRDTLVQSSSVASFGTSDFFPDNPREYSARPYAYENSKDRENDNPQDDADAITPVREAWKSSAPDTGNRNDPAAPPGTPIYYSATTTHAPQPAKAESSDLRHTHADIADRQSHNISPKSRREFVLGQENGGQDGNPTFSSPPEDTSSQNCVMVGSLQEKSGDWLHGWATGLQRRAFDERPKEFTSEWLDGYCEGIKASVQPRTGPTTAPHPSTISTASLTAMSNTGSPMKAHSRRPSPAMASRSSSRLQSVENAPGMSRPPFEISTRSIDGLKQAIVAPQNENAVLTPAANGLHVSETTVNLGAWAKKPHNGPTMELPGLGYPIPQRNSTALRHGIMSEGNNDMGTKAAFDCAPEQLQPTRPALAPTLSTASVASGTIGTGGGISTTGNRISSLASIDSSLPGQWPANRVMTPSEWRYAGASQNTSITTGFFAQSQFDGTDDALLSARPATQLTTGVPGAQQRVTSDSHDRSSSRGRFREGSIDRVTSPPTSPRVMSPATSSHGTPIQRDGKKVSPRKGPSPTKVIGNLAERVGIKVTSPTPFETGDEQASPPGKRHWGMRDWMKSNKGNNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGG4</accession>
    <name>N1QGG4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_55371</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764371.1">
        <property type="nucleotide sequence ID" value="XM_016909356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGG4"/>
    <dbReference type="STRING" id="692275.N1QGG4"/>
    <dbReference type="GeneID" id="27906493"/>
    <dbReference type="eggNOG" id="ENOG502RV5R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052690_0_0_1"/>
    <dbReference type="OMA" id="HEATHIH"/>
    <dbReference type="OrthoDB" id="66964at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF16250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="322" mass="36015" checksum="F9EB704CA0E758A3" modified="2013-06-26" version="1">MLPAVGNDVLSANPNFEALYRDLCVNKLNANATTKVDPKVQKERNAFDEELRAARSEATKRAIIKSYLDSLSYRSDQLPAELQELVAIIAAALQSQMPKEDAGLLREDIDKFQESVKPIAKEIWKTALDDLVTLARISAPEAHSDGDDLPARIQRQKDNIAVLEESLAATRLHLTHEATHIHALSRQALEKCIRTLEQVLHGSVSRSTKARAEYCQIVAEGMSKKLQVQRAQLLSQTKSPEWEAALQTHAAHVDREHMACKRRIREVEEQLEAYYQQTTSAATTTGTGMSSRGVSAAEYKQYSEIIREVSKMRADIAKVENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>N1QH03</accession>
    <name>N1QH03_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AA1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_34938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764581.1">
        <property type="nucleotide sequence ID" value="XM_016908585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QH03"/>
    <dbReference type="GeneID" id="27905722"/>
    <dbReference type="eggNOG" id="ENOG502RMFH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120596_0_0_1"/>
    <dbReference type="OMA" id="NTTCSIV"/>
    <dbReference type="OrthoDB" id="3646616at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109569" description="AA1-like domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF16460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="173" mass="19095" checksum="EEE91E5D5CED6A36" modified="2013-06-26" version="1">MLFLAALVVLVQLALAVPTSNTKNSRRLAVHLTNAITGDCDSLVEESAWVITNLTSFQAYPSANSISYFAFSFEDINPGLGLKTSCSNYLPRGSNATVENDRYHLCDSHDVQFKYNGQILQVERWYQDPCLGKPPYDSAIAHGRANVTFTKTRAQDGVLATQVRMEMPITSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>N1QHD1</accession>
    <name>N1QHD1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_22067</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758679.1">
        <property type="nucleotide sequence ID" value="XM_016908347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QHD1"/>
    <dbReference type="STRING" id="692275.N1QHD1"/>
    <dbReference type="GeneID" id="27905484"/>
    <dbReference type="eggNOG" id="ENOG502T1YW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120766_0_0_1"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF10558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="127" mass="14074" checksum="8DCA612BB1244AF3" modified="2013-06-26" version="1" fragment="single">MFSNPRPVPSKAALRLLYQLAYISSGTAVGVATLCAEERRRRTVLVQKIADNAKRIRESPRYVHNKARKAVDEAEGRYTPLEADATGRAHLTGLDPGDRAVRGPELASVVDAGYDQLVQRPHGRKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1QHE3</accession>
    <name>N1QHE3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Galactose oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_145849</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016903301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QHE3"/>
    <dbReference type="STRING" id="692275.N1QHE3"/>
    <dbReference type="GeneID" id="27900438"/>
    <dbReference type="eggNOG" id="KOG0379">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005349_0_0_1"/>
    <dbReference type="OMA" id="CPMLIYS"/>
    <dbReference type="OrthoDB" id="10001928at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503">
        <property type="entry name" value="MCG48959-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503:SF2">
        <property type="entry name" value="NEGATIVE REGULATOR OF SPORULATION MDS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="205"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="549"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="820"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="851"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1010"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="120"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="215"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="831"/>
            <end position="844"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF16646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1102" mass="117979" checksum="3F9E4FC95C7BD5C8" modified="2013-06-26" version="1">MSVPLGVFAFPAAAEKRSDQSSVKSTKQKKDGHHPSTSTSDTQSAAGRSLDRSRSGLKTRSVKKQSTPLSSRSWVAAFTRERKQPSRSRSDPVVPRAFSTSTAGSSPHDSFDLSTTPLLPKEYSYVPSESEPSSGSFTYSIPSSTAPSPTTASACLPSHPASPRSTPRHVPIKIPYCPDWGTPTKTKCDTTLPRKLSFHQLPPLALSPIPPISPFTMSSTTPESSRANTMDSSVSRPTSGQLYPNSQNGSHANISAHSSQVSLVGMRSEYESASEAESTHGDDNGPSQHTPSQSISSANPQTTSSPANPAGLSGLVCNVHRTTGREPHPLVGATTTVLGDKLYVFGGRRLSRTKPQLTANLYELDLIRRHWTKLDTTGDIPPPRYFHSVCALGDTKLVCYGGMSPAPPQDPAAEAQPEVIVMSDVHIYDVPSQTWTKLNTPDAPQGRYAHCASILPSAAVFASKDAPMSAVHHNPASDKPNEGSLGVHLDGTGGAEMVVVGGQDSANHYIEQVSIFNLRSLKWTGTTGMGRSCGAYRSVVTPLTTMSASQIGAGPHAHSELEEDDEEPTTIGSGSPMLIYSNYNFLDVKLELQVRLPDGTLTEKPMQTAVSPPGLRFPNGGVIDNHFVVSGTFLTSSKQEYALWALDLRTLTWSRIDVGGSIFSQGSWNRGVLWARHNAFVILGNRKRSLVDDYNNRRINFSNICVVELEAFGLYDNPRVAEPTSSYTSASAIPSVLPQPLPPSKDDAAFCRLLSSAAEDIGALALNVRELADMDFLAIDGTRVPVNSRLISRRWGPHFITLLRESLMSAENGADTATLRPNAAGHPSRNSSITITPSLTSTMSGTTTLTNNSLATDTSLPDTRTAPPATRPRLLYLPHTAPTLHALLHYLYISTLPSPPHPLATPQIFCSLLQLARPYKIDGLQEATIERLHQCLDGRNAAAIFNAAAMGAGGGDSIHFATNTRSIPRSDIPVRTASLAGLEGLLNGSQSANPRSLSSLRIDTDMANGRSVRNTLRPGPRAAADDTDEEPMSAVSTTSMSESEIFAHSSKEVQDVWNGALSSVVGLQKRGLRGLMEGRRMREKGRDGFAEGGRVGLGIAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1QHJ4</accession>
    <name>N1QHJ4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">L-tryptophan decarboxylase PsiD-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_145883</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764817.1">
        <property type="nucleotide sequence ID" value="XM_016903319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QHJ4"/>
    <dbReference type="STRING" id="692275.N1QHJ4"/>
    <dbReference type="GeneID" id="27900456"/>
    <dbReference type="eggNOG" id="KOG2419">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033450_1_0_1"/>
    <dbReference type="OMA" id="ANACESQ"/>
    <dbReference type="OrthoDB" id="5973539at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022237">
        <property type="entry name" value="PsiD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF9">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_7G01730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12588">
        <property type="entry name" value="PSDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="L-tryptophan decarboxylase PsiD-like" evidence="3">
        <location>
            <begin position="50"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF16696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="444" mass="49782" checksum="2AFE2DF081578F56" modified="2013-06-26" version="1">MVHQHGDHHDIPDDKKKVKAGAWLPADHRIHEEWLDRQIDHAKKEKKPLNPVLQEFKEFVENNTRVRMLFTQMFQEVPVKHPYNKDPTGRKQVRDFYHFLEILNHTYTSAPTWTDAAASVGMVGVPLCAILDYPMGTPSGYAAFIDPDVNKMLKKVLNEWGRFLLTPKSAEVLHTGKQGWFGEVGQKDIMEVANAPYQTSHKFEDFFVCDPKAKHYGYKSWDDYFTRHFRDEVRPIASPDDDNVIANACESKVFNVAHNVKLRDHFWIKGQPYSISDMLAHDPLADNFAGGTVYQAFLSALSYHRWHAPVSGTVKKAFVQDGTYFSEPLFEGLGEAAEIDVGGISVGQGYLTALATRAIMFIEADNPAIGLMAFIGVGMDEVSTCEITVKEGDHITKGQETGMFHFGGSSHCLLFRKGVKVSGFPETGRAANVPVRSQVAVVQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1QIG9</accession>
    <name>N1QIG9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_146136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016903472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QIG9"/>
    <dbReference type="STRING" id="692275.N1QIG9"/>
    <dbReference type="GeneID" id="27900609"/>
    <dbReference type="eggNOG" id="ENOG502SJAV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060131_6_5_1"/>
    <dbReference type="OMA" id="KAKWNIW"/>
    <dbReference type="OrthoDB" id="4738875at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF14">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="81"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF17026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="216" mass="24550" checksum="6B3AE1DF2BCDC9CB" modified="2013-06-26" version="1">MPVKAIPAEDADFERIFEITSLAFDRNEPVWDAMWPSHWLPQGRQQGAERMRKTKNTTPETTYIKAIDTETGKILGMAKWNIFQNYSPSRSEVPDIYENNQDRDYAQGVVDAFLATRNQAIKERDGNVIALDILTVDPAYQRQKVGSCLVEWGTRKADEMGFDAVVESSVFGRGLYEKHGFEYQNDVQVTVPGYENDASRPTGSFAWMVRPKTTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1QIP7</accession>
    <name>N1QIP7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Golgi SNAP receptor complex member 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_146193</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of several multiprotein Golgi SNARE complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the GOSR1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EMF17101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016903509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QIP7"/>
    <dbReference type="STRING" id="692275.N1QIP7"/>
    <dbReference type="GeneID" id="27900646"/>
    <dbReference type="eggNOG" id="KOG3208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078034_1_0_1"/>
    <dbReference type="OMA" id="QAYAVND"/>
    <dbReference type="OrthoDB" id="422156at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048219">
        <property type="term" value="P:inter-Golgi cisterna vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023601">
        <property type="entry name" value="Golgi_SNAP_su1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21094:SF2">
        <property type="entry name" value="GOLGI SNAP RECEPTOR COMPLEX MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21094">
        <property type="entry name" value="GOS-28 SNARE- RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027109">
        <property type="entry name" value="Golgi_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="209"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR027109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF17101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="227" mass="25788" checksum="4040B6C836ECCAB7" modified="2013-06-26" version="1">MSMTANMGSWAQLRQQARSQETQTESLFHTYAQFASKTDLDPQPSEVERRTEEQLIQLLEKRTATLASLQRSLDSEPTPSALKSTNLARHREILSQHRSELSRLKSQISQSRDRANLLSNVRKDISSYRNAQNPEAQEAEYMLQERNRLDRSHNVADSVLSQAYAVNESFGLQRESLAGIQRRITGAAAQIPGINGLMQRIGSKKRRDGIILGSFIAICFLVLLWFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1QIV1</accession>
    <name>N1QIV1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_104428</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765246.1">
        <property type="nucleotide sequence ID" value="XM_016900540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QIV1"/>
    <dbReference type="GeneID" id="27897677"/>
    <dbReference type="eggNOG" id="KOG2765">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025401_0_0_1"/>
    <dbReference type="OMA" id="AVYIQHQ"/>
    <dbReference type="OrthoDB" id="10062838at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026505">
        <property type="entry name" value="Solute_c_fam_35_mem_F3/F4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19346">
        <property type="entry name" value="SUGAR PHOSPHATE TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19346:SF4">
        <property type="entry name" value="SUGAR PHOSPHATE TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="325"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="372"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="476"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="508"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF17125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="548" mass="59985" checksum="C1BC69F0573408DC" modified="2013-06-26" version="1">MCSTSLGPAIATPQPRRHIIIISTTTTTTTTTNHSAHALLVAVPFSNTVFLHPPTPSLPPALSHPPTYPHAVVYSGPRRPRGGGPDAIAWDEAERPREEDCDMPSDLRPERSRPKSYQHQPLLAGDKRTSHDSPTRPAGLAARRSSHFRERDPEVVEAVDDTRRRYTYAAAFLLLSLVSFAVQTETAVYIQHDLHWNKAYCMLYFTHGSWSVLWFVQLAILRMHKWSQPWDSFWRRHVAIITSTAQMVEHRTLNVPLHLQKKSPWPYFARTTAYVTCALTVAGASWYIAVDMTTASDLTAIYNCSAFFAYAFAIPLLGDRLQCNKIASVVLAIIGVLVVAYGDQAHPKHGSKSGGGAGGPSAPDSAAASSRTLGNLVIGVGSVLYGFYEVLYKRVACPPNGCSPTRGMLFANTFGSMIGLFTLTVLWIPLPILHYTGIETFELPSGEAAWMLAISVLSNATFSGSFLVLISLTSPVLSSVAALLTIFLVALCDELLPPPLYSPLTSAAITGGLLIIAAFLLLSWFTYKEMEEEMHKNAEEVESDVEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1QIZ2</accession>
    <name>N1QIZ2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Isochorismatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_49038</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758680.1">
        <property type="nucleotide sequence ID" value="XM_016909095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QIZ2"/>
    <dbReference type="STRING" id="692275.N1QIZ2"/>
    <dbReference type="GeneID" id="27906232"/>
    <dbReference type="eggNOG" id="ENOG502SMMI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068979_0_0_1"/>
    <dbReference type="OMA" id="MRDTWNA"/>
    <dbReference type="OrthoDB" id="167809at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00431">
        <property type="entry name" value="cysteine_hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540:SF9">
        <property type="entry name" value="FAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
        <property type="entry name" value="PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="217"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF10559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="319" mass="35061" checksum="671B6AB51DE984E6" modified="2013-06-26" version="1">MSTTDRNEYEHHRAVVGNGRNFWLYSSQTGFDLTHPETPTTPHLPTSITIETTTSPIAIDPSKSALIVIDMQNYFLSPVLGRTKGAGHAAVDQLIEYAVPAARRAGIRVVWVNWGLTDKEVEEMPPAVKRAFGFEAVVDSSGKEKFDGIDVEGFGVDRHGKKSGRKHHGIGSDMGIVKDEHGTDIEAGRVLMRGAWNSALFPPLDQVYEEGKKLGNKPDVWIHKNRMSGMWGVGTDLETFLEQEGIRTLFFTGVNTDQCVGGTLTDSFSKGYDCIMLGDGAATTSPEYAQKCYEFNSANTYGFVTSCKQFAAGVQRREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJ01</accession>
    <name>N1QJ01_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein S16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_157754</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS16 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758690.1">
        <property type="nucleotide sequence ID" value="XM_016907750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJ01"/>
    <dbReference type="STRING" id="692275.N1QJ01"/>
    <dbReference type="GeneID" id="27904887"/>
    <dbReference type="eggNOG" id="KOG3419">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100590_2_2_1"/>
    <dbReference type="OMA" id="MANDTYV"/>
    <dbReference type="OrthoDB" id="407221at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00385">
        <property type="entry name" value="Ribosomal_bS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000307">
        <property type="entry name" value="Ribosomal_bS16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023803">
        <property type="entry name" value="Ribosomal_bS16_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00002">
        <property type="entry name" value="S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919:SF20">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS16M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00886">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54565">
        <property type="entry name" value="Ribosomal protein S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="116"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF10569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="158" mass="17803" checksum="C46F5B74B4891FD9" modified="2013-06-26" version="1">MVLRLRLSRVSTPSGAKRHSPFYNIVLAQDKTARDSKPMEVLGTYDPIPKLPVGAEPGQKKQKDIKIDVSRAKYWLGVGAQPSDTVWRLLSMIGLLEPRYLPSGPQTLKATRFPTHLPKTDGVVRQTESDRLQKRMAPFRSGKKPVTQAIEEQQRSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJ14</accession>
    <name>N1QJ14_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_146250</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765286.1">
        <property type="nucleotide sequence ID" value="XM_016903541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJ14"/>
    <dbReference type="STRING" id="692275.N1QJ14"/>
    <dbReference type="GeneID" id="27900678"/>
    <dbReference type="eggNOG" id="KOG1502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_9_2_1"/>
    <dbReference type="OMA" id="WDFVETE"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="3"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF17165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="371" mass="40432" checksum="8A6EE7BE75706E2E" modified="2013-06-26" version="1">MRVLVTGGSGYLAGHIIDQLLQRGHSVVTTTRTQAKASGLLRRYAQHGKDVFDVVIVEDIAVEAAFDQAVVSTPPFDAVCHPTSPFYFDVTDIQKELLDPAIMGTIGILQSIKAHAPTVRRVVITSSLASMIHPWQGDWPGNWPGHVYTEADWNPITLDQALADVLCGYRFSKKQAEQAAWNFLATERPNFTLQTICPPLMLGPTASGDLWEGSLANVNESLKRVRDICFGKARAENEIPPNGASFVFTDVRDAAHYHVLALERPEEVSERYFIPTGWFANEDIARIARDHFHDLAADCIPLPGTPGGGWPQDGMYTVDNSHTRNAFPDLVTFYSLETCIVDTVRSLLAVVASASASASASSSSSSPSFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJ92</accession>
    <name>N1QJ92_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_48956</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758755.1">
        <property type="nucleotide sequence ID" value="XM_016909089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJ92"/>
    <dbReference type="STRING" id="692275.N1QJ92"/>
    <dbReference type="GeneID" id="27906226"/>
    <dbReference type="eggNOG" id="ENOG502RBCG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010595_10_2_1"/>
    <dbReference type="OMA" id="FPLYVCI"/>
    <dbReference type="OrthoDB" id="506498at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF10634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="32022" checksum="7B1F4740BED68200" modified="2013-06-26" version="1" fragment="single">DEADVLDCGYGKAAWVDKLLGYRPDAVVVGIDLFTGQGNSDEDEDEEDDEDGDGIESFIRKRWNLNIPLRQDTSSDRLRPETFDLINSRMLIDGINANRWETYVRELYALLKPNGWLQMVEFHAIFQSDSGRDAPFLSRWWDWYSQKLLQMGKNPRIASQLKPLMVNAGFTDVHYHVSRLPVGNWDPDRVQLGIQARDLITQMLRDVSLYPFLALGRMPREQYENLLEGARRELHQPGLKLYLNVSVFTAPHFIAESHAADDSCRHVAYGRKARRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJI3</accession>
    <name>N1QJI3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arp2/3 complex subunit Arc16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_164307</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760096.1">
        <property type="nucleotide sequence ID" value="XM_016908108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJI3"/>
    <dbReference type="GeneID" id="27905245"/>
    <dbReference type="eggNOG" id="ENOG502QU9T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029940_1_0_1"/>
    <dbReference type="OMA" id="WWEFSNI"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10938">
        <property type="entry name" value="CE4_HpPgdA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037950">
        <property type="entry name" value="PgdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47561">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G05030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47561:SF1">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G05030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="2">
        <location>
            <begin position="29"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF11975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="312" mass="35893" checksum="B11C1E96D3B0B99D" modified="2013-06-26" version="1">MGKKRVLVSYGVDIDAVAGWLGSYGGEDSTSDISRGLWAGTIGTQRLLKLFEKYNIKATWFIPGHSLETFPEDCAAVRDAGHEIGLHGYSHENPADMTFEQQRDVLDHTYKLLTNFCGKPPRGSVAPWWETSKEGTELMLSYGIEYDHSMSHEDCQMYWLRTGDQWTKIDYTKQAKEWMKPLVKGESTGLVEIPGSWYIDDLPPMMFIKKSANSHGWVNPRDVEAIWMDHFDYYYREYDEFVFPMTIHPDVSGRPHVLLMHERIIEHINKHEGVEWVTMEQMCDDFKSKNSPPAGAMMPASKEEVLKKLQSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJJ0</accession>
    <name>N1QJJ0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_146414</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765491.1">
        <property type="nucleotide sequence ID" value="XM_016903639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJJ0"/>
    <dbReference type="STRING" id="692275.N1QJJ0"/>
    <dbReference type="GeneID" id="27900776"/>
    <dbReference type="eggNOG" id="ENOG502QWTJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008719_4_1_1"/>
    <dbReference type="OMA" id="IWVHPPP"/>
    <dbReference type="OrthoDB" id="5319341at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF3">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="50"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF17370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="583" mass="64397" checksum="AECC504AC0897AEB" modified="2013-06-26" version="1">MKCDEVKPQCGPCAKGNRPCVYGPLPPEPDSATAGGVASIPPYYAASGAEIPLPVHDRPPPASVATEPGAQSNVLPEQSETRIGKQWSAAPVDEVTQITSPQSSSSTSTGYGTEVAPLHWFGLLAGDAATGSLDVPSLEVLGDAALARRHDAHTDGAAHPNLPRPVSRPYLGLDSFASQSPAKLLQLSAWCPTTNSAKGAEDERQHWQAAEPIQLKDHEFDIFQRFVTGISLWIDLFDPLKHFSTLIPHLALHNEGLMKALLALGARHLSIKPLRTGEANVDRTAAVQYYYETLRYLQTAMRYTTYKNSRELLATALIVSTYEMIDGAGNGWERHLKGVFWIQRSREINGESGGLEQAIWWAWLRQDVWAAFRENRRCFSFFKPTKQMMDIWDMASKVTYILAQAVNYSSREEKQLGQADLTTQIARANTLLNMLDDWRSSISIHFNPLPVEGPSNRAFRPLWIHPPAFGASVQMSCMARILLLIHQPAAGGYLEYLQRDKVISECIDTIGGIAMKLTDNASRLMSTQCLYAAGLYCTDGPKCQYIAELIQDHEGHTGWPSNTDLAEELRGEWSKRPKGDAQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJK8</accession>
    <name>N1QJK8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Scytalone dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_36082</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the scytalone dehydratase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765511.1">
        <property type="nucleotide sequence ID" value="XM_016908627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJK8"/>
    <dbReference type="STRING" id="692275.N1QJK8"/>
    <dbReference type="GeneID" id="27905764"/>
    <dbReference type="eggNOG" id="ENOG502SNND">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101889_0_0_1"/>
    <dbReference type="OMA" id="ARIKTQH"/>
    <dbReference type="OrthoDB" id="5281072at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030411">
        <property type="term" value="F:scytalone dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006582">
        <property type="term" value="P:melanin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004235">
        <property type="entry name" value="Scytalone_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049884">
        <property type="entry name" value="Scytalone_dh"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02982">
        <property type="entry name" value="Scytalone_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF024851">
        <property type="entry name" value="SCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Scytalone dehydratase-like" evidence="6">
        <location>
            <begin position="9"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR024851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR024851-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR024851-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF17390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="180" mass="20172" checksum="CA0F30F4FA64AD40" modified="2013-06-26" version="1">MSDCSSLTELADVMGCQAALFEWADSYDAKDWARLRECVAPSLMVDYRAFLNKKWDDMPADEFVQMASDSHFLGNKTIKTQHFHGGSRYEQESDDKIIGHHQMRVAHQKYADESLQTVVAKGHGHGTATIWYKKVDGVWKFAGLIPNTRWTEYDFHKIFGGHHDADAESGGESSGTASPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJU8</accession>
    <name>N1QJU8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_146510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765632.1">
        <property type="nucleotide sequence ID" value="XM_016903699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJU8"/>
    <dbReference type="STRING" id="692275.N1QJU8"/>
    <dbReference type="GeneID" id="27900836"/>
    <dbReference type="eggNOG" id="ENOG502S3YN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_385418_0_0_1"/>
    <dbReference type="OMA" id="FGPAFPM"/>
    <dbReference type="OrthoDB" id="21449at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15398">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15398:SF4">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 8 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="73"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="166"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="530"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="856"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="172"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="277"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="342"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="366"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="664"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="708"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="856"/>
            <end position="866"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF17511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="880" mass="96764" checksum="F5232D6FB9D8CCCE" modified="2013-06-26" version="1">MTITAYTHLESLLLFQALRHEGVNTISFNRISEQLKSVPLIRNDPAFDAGRLSPDALRELYLGLLKEEVKHDLEQQQNAEKHLTNGNASPSSRKRKMASPVLPTVHEAAQHSHLIPQLVFRLYSRYRDNAILKIKGYESRYAEGKQYIEDVEAGLWDERLQREDSARRVQERAAAQAQSPKASPKPSSTAHTQPVLAWPDRARTPSANASPVLPKQPDGSAQAPPKRYSQAKIDAVINHGPEPQDGPGGHARASSNTKLPPLSEMAPQSPRFGIPPNISSHIPQQMQAVPAHTHAPNHNFGQTPPGGHRSPYGSHHGHPRQSSMSSPQVQQSLSRPSSSPRPILPPPPGMSLPPPSPVMHTGSPSQHQYAVPMQQQQHYQHQHHPSSKSPAGPYQGSQLPPHASGYYQPPPTQQQPPYQDRRQPYQPQHPQTPTYPHQTQHTTLMQPHQSHMPAGGFMQPFQVAPQDPSRPVHHQPLRSNQPPVLHSQIASTYVAQSHGTPATAPRLAIQPSRKMQDVLSMLATPPRRRVKPLWKEKYQPSPLMPSAEKPRPAIEPLSPTQERTVPARLVRSHRGHEVPSVEEPVQTYPPPKIRAQRRKGNHRDKSPGGHSVVSSTADDSHRARTRSQSVSTAAGANPGSDDRPPSRSGVKTESLTPADTFDDAAALSATPASARVTRKRRGTLQSQHQPGAKRKRQESPGRTEDVESSTPVPRSNTVIATRNFNKMSSAIMSDIQSHKHATYFAGPVRDKDAPGYSDIVRQTQNLKAIKAAITAGAHVVKAAASSTDSPSEAVGANSSTVELERTVDTIPPKVIVNGAQLEKELMRMFANAYMFNPGEDGMALSTKEMFDEVEQKISEWRGTERAADDDDEGKGKRRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2023-02-22" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>N1QK43</accession>
    <name>N1QK43_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_119445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759055.1">
        <property type="nucleotide sequence ID" value="XM_016901508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QK43"/>
    <dbReference type="GeneID" id="27898645"/>
    <dbReference type="HOGENOM" id="CLU_1836410_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF10934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="140" mass="15702" checksum="2ACDB878E0644F27" modified="2013-06-26" version="1">MLDIPSLEFVVRRDMLESGSFIQVVTHTIQLVLPEKHTFYGNFKMYAIAEAEDSTPRGAICVCDLQALVSDMNRKKEALIHTDDMFDPYIPLPVVPVGEYVVAFVEAEAFKDFVLRLRSNVTNETDLDRCASCGEVVVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>N1QK77</accession>
    <name>N1QK77_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Wings apart-like protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_46918</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760346.1">
        <property type="nucleotide sequence ID" value="XM_016909021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QK77"/>
    <dbReference type="STRING" id="692275.N1QK77"/>
    <dbReference type="GeneID" id="27906158"/>
    <dbReference type="eggNOG" id="ENOG502SFJA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_302110_0_0_1"/>
    <dbReference type="OrthoDB" id="78088at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022771">
        <property type="entry name" value="WAPL_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07814">
        <property type="entry name" value="WAPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Wings apart-like protein C-terminal" evidence="2">
        <location>
            <begin position="555"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="524"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="333"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF12225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1013" mass="110168" checksum="81B606C2C3B5960E" modified="2013-06-26" version="1">MAAMSALAHARRRKQATYGKASRNSSAWNITGFADDEDELASAASVVAQPAVEVRPTDTQRVGKRISEPRRPPKHVESRSMKQDMWDVPSSDDDVGNSIMRRSPPKPVGRRKIDSVVEEDVPLAPWEQKRTLRTGTALAEPAGANKIATEMQIRAKTGPQAQQGKEVLPSAESVSPEKLVSPGTGSAADRLKARRQLLDRSAASVASEMQKSSPTTQKRLEHGSSDSNPTPRKRHRQAKEATEDGGDVVMLDVPGCSLSSVQAATKVLPMASSIAGEDASLKSRAASRQQVQRNPRRGKLSNVSRVSPQTMVSAPARLTEMLVDDTDATPDYSHSPSTFTSRPSTPQKHSGSTGTSSPETARKITSTPKQDHLWSQLLSEDSAVGSPSVLPLDGLTLHADRRTGVKRTAATRILTKSSSDIGPTRERPKLVDRLKASAPSSDSDRSGSEQDESDAEDVDMSSDEPAAHESGHCQSQSYSQSTAFVESVPRITYSRVRSYLPEDSFEDGLMLSIPSAPKAAAAPSISRKMTSSNSASQQSIYDLPDSDDEDTNGRLRTVHELRAAGSNQRFMDETSGLLDDIAVHAMSARGRRRSALVELTKKLMASKAFVEKFFRQGFEQKLLAELAAPADEIADFVLAVALVSLLTEECPEHAAKSMKERHATAWLAQRLMNDSCMAKRAKDRKNNMSKAAQATFIEFVDIACAHDTFWGDLRPTAITTRTVVLKALDSLVGKLRRSGDRSELLGREEVRAILFSEHELDLLMGREEDLPTDMCLSVSTLENLATLSDGNSWPPDVVQQLGKLLISPMLASEKLRHLRFLALRLCSNLTSDNVRSCRQLTKLTVVHSLLECVSRGLRGLGSSMEAIDLDVLVLEMGVTINVAEQVESARASAASRETAPILVQLVTAFNAGQKRLLEAETEEGAAANVAYAYLAVVLAILCRNREAKVVIAGQLPGQKLHTLIEVVEEFIRHQSRVDKLAFGGEEGGEVWTAFTEKLKGILERLKTAAEQDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKK7</accession>
    <name>N1QKK7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dynamin_N-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_164126</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759852.1">
        <property type="nucleotide sequence ID" value="XM_016908096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QKK7"/>
    <dbReference type="STRING" id="692275.N1QKK7"/>
    <dbReference type="GeneID" id="27905233"/>
    <dbReference type="eggNOG" id="KOG0446">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008964_7_2_1"/>
    <dbReference type="OMA" id="ERYGHEY"/>
    <dbReference type="OrthoDB" id="415706at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001425">
        <property type="entry name" value="Dynamin GTPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF215">
        <property type="entry name" value="DYNAMIN GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="6">
        <location>
            <begin position="29"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="5">
        <location>
            <begin position="646"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="423"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="428"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF11731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="735" mass="81874" checksum="B0F0507DBFCC220C" modified="2013-06-26" version="1">MAPTSTTALADPLMLDKIDKLFACGVGEIVDLPQIVVVGDQSSGKSSVLEGLVGKPLPRDSGLCTRFATQIVFRRAKLQGIEVSIIPDKDADPQHVARVKKWARKVEEELDSKVFIEIMEEVHIEMGLAGHGDDDGVKRPTFSNDVLRLEISGPNEEHFSVIDVPGIFKSRTEGVTTKADITLVRNMVHGYMNNPRSVILAVVPANVDVATQEILELATEADPEGDRTLGVLTKPDLVDKGAESQVMDLLEGRTRAMKLGWHIIRNPGQMEMSAKDMDRSSLEKVFFRHQAPWNELERDKVGIDTLRVRLKEVISSLVKKEFPKVKKETKDRLEIRLKRLEQLGPERTGTIEQIAHLTKMATQFQRIVTLALTASYGADEVFDGNDDLRIAPTMMARMKAFSDDMASQGQTYAFMQEGLGETESTGIEGEDEGETESTGIEGEDEGEKARIPARWYCHGEELFGIQYSIEYHNDSVRSPKTRGIKTWLRDIFLGNRGFELGTFNGSILATAMKKQSVNWHNLSLGFLSDVIVIAHRFILAALKAVCGDSEIRLALESTLLDDLTTRYEQAIANAKFLLKVESCDTPTTLNHYFNDNLQKSRQNKATAGLDSKAIDISRHHHSWSAMVPLADVKRQAINMSNDEYAICEIHDILKSYYKVSRKTFVDNICKQAASHYLLHSETSPLALFSPIWVSQLSAVELEEIAGEAAGVKRARSVLTKEIESLKAAMKMLARH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKM9</accession>
    <name>N1QKM9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">VPS37 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_78302</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS37 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765856.1">
        <property type="nucleotide sequence ID" value="XM_016910190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QKM9"/>
    <dbReference type="STRING" id="692275.N1QKM9"/>
    <dbReference type="GeneID" id="27907327"/>
    <dbReference type="eggNOG" id="ENOG502S268">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088665_0_0_1"/>
    <dbReference type="OMA" id="SWRKKQT"/>
    <dbReference type="OrthoDB" id="10260857at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009851">
        <property type="entry name" value="Mod_r"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13678">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13678:SF2">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07200">
        <property type="entry name" value="Mod_r"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51314">
        <property type="entry name" value="VPS37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS37 C-terminal" evidence="7">
        <location>
            <begin position="80"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF17735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="169" mass="19356" checksum="0BFEE444943281F2" modified="2013-06-26" version="1">MLKDKSVNDLQDILNSQSFQAALLSSPHTTHPSIPLAEQHLPPLLQANLAAASKLLDTESRLSDLRERTQSRLLALRAMEQQHRSKISETEAALRDFSPQALYQRLNASVQEQELLLRGLEESWLEEDGVASEREVTEFVKRTKDARKVAFLRRERKSRWDDGRVGGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKU3</accession>
    <name>N1QKU3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">RuvB-like helicase</fullName>
            <ecNumber evidence="13">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SEPMUDRAFT_145545</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the RuvB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="13"/>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764364.1">
        <property type="nucleotide sequence ID" value="XM_016903120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QKU3"/>
    <dbReference type="STRING" id="692275.N1QKU3"/>
    <dbReference type="GeneID" id="27900257"/>
    <dbReference type="eggNOG" id="KOG1942">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028311_1_1_1"/>
    <dbReference type="OMA" id="RTLPYNK"/>
    <dbReference type="OrthoDB" id="10060499at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097255">
        <property type="term" value="C:R2TP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.360:FF:000001">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 13" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="13" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="83"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMF16243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="504" mass="54236" checksum="3C6553539848DD37" modified="2013-06-26" version="1">MATNGAVAPAPAAAQTGNVPVQISEVRQTNSRENRTAAHSHIKGLGLRPDGTADPNGGGFVGQTAAREACGVVVDLIRAKKMAGKAVMLAGGPGTGKTALALAVSQELGTKVPFCPMTGSEVYSAEVKKTEALMENFRRAIGLRVQERKEVYEGEVAELSPEETENPLGAYGRTISHLLITLRSSKGTKKLRLDPSIYEAIQKERVRLGDVIYIEANTGAVKRVGRSDAFSTEFDLEAEEYVPVPKGDVHKKKDIVQDVTLHDLDVANARPQGGQDVMSMMGQLMKPRKTEITEKLRGEINKVVNKYIDQGIAELVPGVLFIDEVHMLDIECFTYLNRALESTISPIVILASNRGQTTIRGTGSVQANDPGLISAHGIPPDLLARLLIVPTHPYTGSEIRTIIQTRAKLEFATPTAPQLADNPQALKVSATLSPEALEELTKRGETVSLRYALQLLSPSSILARARGSEGNVISASDIDEATSLFWDAGRSANQLREQASMFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKX2</accession>
    <name>N1QKX2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_113824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765966.1">
        <property type="nucleotide sequence ID" value="XM_016901055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QKX2"/>
    <dbReference type="STRING" id="692275.N1QKX2"/>
    <dbReference type="GeneID" id="27898192"/>
    <dbReference type="HOGENOM" id="CLU_1147800_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110416" evidence="1">
        <location>
            <begin position="19"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF17845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="242" mass="25686" checksum="75BAE563E296FB06" modified="2013-06-26" version="1">MLPLMLIYAGLFFTLVAGDSVNTISQKLVCRTALKTSSGSGGRTTSSTTIHLSRTVTHVVTPTLTITPPVSTTTKKTTITQTSTATFPQSTNAFSTTLSFTATSTAYTTLISTSTSSVTQTTTSTFATTTIQPSSGFVPISSALAAAGHAAAKRARRGVDMVHRDVAAVEKRKAHQQIVCGDDGSITYTPRQYQGAVTCYQRIQVVTTKTVTSTAQKTKTITAHRLTTTITRRLVASLRNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>N1QLA1</accession>
    <name>N1QLA1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycosyl transferase CAP10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_145659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764519.1">
        <property type="nucleotide sequence ID" value="XM_016903184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QLA1"/>
    <dbReference type="GeneID" id="27900321"/>
    <dbReference type="eggNOG" id="KOG2458">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028539_2_1_1"/>
    <dbReference type="OMA" id="HFAFWAW"/>
    <dbReference type="OrthoDB" id="202415at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF107">
        <property type="entry name" value="GLYCOSYL TRANSFERASE CAP10 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="1">
        <location>
            <begin position="188"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF16398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="470" mass="54056" checksum="2ABA688DAA3F5DAD" modified="2013-06-26" version="1">MWTYNSPPLGQHLSRWSVQPGVWQFTCAILLLLLVSREYSHREVRAPTPSAFAIPSDPVIEIHSKSTAAQPILDSLSKSGTPWQYDWQRDGNNQYLAASQCDAAFPLLYHEIERAQQRFGAANITEDDIDLFREGTGNDGGVRILIVDSQVRIILTRGLFREDFRHRIIAIVQQVVQAVAAADASGEAIPNIEFSVVVDDIAVLDQKKPGALWSFTRRDADAVHDNLWLIPDFHFFAAPPEAEGFRTMQAKFRTHDSSLEQKLPQVVWRGATWTNKPVRQSLLDVTAGKEWANVSEMSWENLATVIPMDEFCKYRYTVNTEGRAWSARMTHLFNCDSLMFVHDVEWVAHYYHLLDTGHNCISVARDFHDLEAKIQYYEHHLDEAQQIADRAKETFRQRYTTPAATACYWRKLMRTWSTVAFEPQIHIPSDDEETSSSPRKRIRGITFEEFILHLNDQDYPYQKKKKNQNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1QLA4</accession>
    <name>N1QLA4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Peptidase_A22B-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_145660</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase A22B family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764524.1">
        <property type="nucleotide sequence ID" value="XM_016903185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QLA4"/>
    <dbReference type="STRING" id="692275.N1QLA4"/>
    <dbReference type="GeneID" id="27900322"/>
    <dbReference type="eggNOG" id="KOG2443">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023799_1_0_1"/>
    <dbReference type="OMA" id="TFWTGTL"/>
    <dbReference type="OrthoDB" id="29661at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098554">
        <property type="term" value="C:cytoplasmic side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098553">
        <property type="term" value="C:lumenal side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042500">
        <property type="term" value="F:aspartic endopeptidase activity, intramembrane cleaving"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033619">
        <property type="term" value="P:membrane protein proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007369">
        <property type="entry name" value="Peptidase_A22B_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006639">
        <property type="entry name" value="Preselin/SPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174:SF23">
        <property type="entry name" value="MINOR HISTOCOMPATIBILITY ANTIGEN H13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174">
        <property type="entry name" value="SIGNAL PEPTIDE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04258">
        <property type="entry name" value="Peptidase_A22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00730">
        <property type="entry name" value="PSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="446"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="45"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="511"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="556"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="511"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="560"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF16403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="615" mass="68308" checksum="7EBA85EBBEEEBC00" modified="2013-06-26" version="1">MALDMNELLTAAAHHWQQNRHLWPMYLHLLLAALFPIYTGAHASLSRPSSAAKPEKKKEKEKEEGDNDEDGEDEEEEETIQQVEGLTPRDALIFPLMAGTVLAGLYWLIKTYGAGIINTVLGLYFSLIGTYSVAKLINDSWITMASLIMPRYYSDQGKIWKVQHHMRRAVALGSESATRTTPFAGPLGRLPLPAPLLSFAWRLRDVVKQRYQVKGFAKHVFEFKIVATRLNAASGILGISAIIYSLLVDKPWWLTNLQGFGVCYGALQLMSPTTFATGSLILSGLFFYDIWAVFFTPLMVTVATNLDVPIKLVFPRPQDPSAAPGEQRAYSMLGLGDIVLPGLMIGLCLRFDLYMHYLRKQKQTQKQVCDGDVCTLKTEVEKAPYVTVSGKWGDKLWIRGSSHLDLPAALSTSFNKPYFSASMIGYVIGMIATLVFMSIFRHVQPALLYLVPGVLISTWATGLIRGELKEMWNFSEAITGEAEDDDEKEGETTTESKGLFADLWADIFGSSEKEETSETKKGSDDSESNNPKPTDRAETDPDSIFFFEISRCKRGAAPEAVTSVRSASASRASSNLEDEDSVLVSRPDPDAEETQPRFRVVSTQQGTAEKHQRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>N1QLP9</accession>
    <name>N1QLP9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">SEPMUDRAFT_68057</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760412.1">
        <property type="nucleotide sequence ID" value="XM_016909808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QLP9"/>
    <dbReference type="STRING" id="692275.N1QLP9"/>
    <dbReference type="GeneID" id="27906945"/>
    <dbReference type="eggNOG" id="KOG4198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022834_2_0_1"/>
    <dbReference type="OMA" id="DWKCGEN"/>
    <dbReference type="OrthoDB" id="448399at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140453">
        <property type="term" value="C:protein aggregate center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071502">
        <property type="term" value="P:cellular response to temperature stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031445">
        <property type="term" value="P:regulation of heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06133">
        <property type="entry name" value="ERI-1_3'hExo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12452">
        <property type="entry name" value="RRM_ARP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1060.10:FF:000021">
        <property type="entry name" value="MUTL protein homolog 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1060.10:FF:000024">
        <property type="entry name" value="RNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051274">
        <property type="entry name" value="3-5_Exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047201">
        <property type="entry name" value="ERI-1_3'hExo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034351">
        <property type="entry name" value="Nrp1_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23044">
        <property type="entry name" value="3'-5' EXONUCLEASE ERI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23044:SF61">
        <property type="entry name" value="3'-5' EXORIBONUCLEASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00641">
        <property type="entry name" value="Zn_ribbon_RanBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="12 14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="17">
        <location>
            <begin position="320"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="18">
        <location>
            <begin position="427"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="18">
        <location>
            <begin position="515"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="398"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="559"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="663"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="411"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="567"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="597"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="663"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EMF12291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="21">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="716" mass="75401" checksum="C5CC92103E7BBF93" modified="2013-06-26" version="1">MATPTQQQQPYGGNPYSSPATNTGGGGAPAQQQQAPYQPESRPPQSAPAPYQPQQQPQQQQAAQTPFEKYCVIHIATTCDEHGVYVTKDSAEVIEIGWVVVDAQNPERELHRQSVLVRPVNTPITPLCTSLTTLTWEHVKNAGTFRDAITAFDQFAQEHLVHKDAGPSAAPTFAFVTLTPWDLRVQLPREARDKNVVLPAYLQHPILFGLRGEYQTFQSHHPETLAFSSSSLSSICAGLEVEEVRSSGKVTGGLPFHLQALAPSSPRRALEEALTLTRCLNSLLKKSRPSATNPQGSPEILQRPLDARSDVRAFLGERSKVLHLSGLPHDTTQSELESWFTQYGGRPIAFWTLRTPEGGKPSGSGFVVFGSHEEAAESLSMNGRALNDRAIEVAPSSSRVLDRAAHSQPSGGPPLLTPFPPSKNRPRPGDWTCPSCGFSNFQRRTACFRCSFPAMGASGPDPYSQPYGMQAAPYGGAQFGHPGMMGGGHMHGGSFGGGMGGMGGSSGRGGIVPFRAGDWKCGNEGCGYHNFAKNVSCLRCGASRSNAAVIAESGMTSFPGQSYGGPPQVPMQQPPPANYGGGSQQSFDSSAYGAMQGPPAGFGSQSFGPPSSYNMPSGMPQPSPYMAGGYGQMASNGGIPAQAGFDSRTEQAFNQGNAGAQAGAGAYANGAYGPPGGYGNDGTADPFSFLSAGMGQLGINEGDSRRNGAGASKSPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1QLS0</accession>
    <name>N1QLS0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Ubiquitin-like protein ATG12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_33280</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Forms a conjugate with ATG5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Preautophagosomal structure membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ATG12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764864.1">
        <property type="nucleotide sequence ID" value="XM_016908534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QLS0"/>
    <dbReference type="STRING" id="692275.N1QLS0"/>
    <dbReference type="GeneID" id="27905671"/>
    <dbReference type="eggNOG" id="KOG3439">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106795_3_1_1"/>
    <dbReference type="OMA" id="DLPMNMS"/>
    <dbReference type="OrthoDB" id="10003551at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034274">
        <property type="term" value="C:Atg12-Atg5-Atg16 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01612">
        <property type="entry name" value="Ubl_ATG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007242">
        <property type="entry name" value="Atg12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13385">
        <property type="entry name" value="AUTOPHAGY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13385:SF0">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN ATG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04110">
        <property type="entry name" value="APG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3 6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="4 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF16743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="134" mass="14931" checksum="311880ACA2318C38" modified="2013-06-26" version="1">MSTSPEDDVLEREGADLPMTIAASVVLEHLPKDAARALDTAGDVEQAKVTIRLSPLPNTAQLRQPRFKCSSNQRFEYIVRFLRRKLALQDHEAVFCYVNSVFAPGLDEAVGNLWRCFKTGDELVVSYSITQAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>N1QM00</accession>
    <name>N1QM00_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DRMBL-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_146350</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765403.1">
        <property type="nucleotide sequence ID" value="XM_016903593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QM00"/>
    <dbReference type="STRING" id="692275.N1QM00"/>
    <dbReference type="GeneID" id="27900730"/>
    <dbReference type="eggNOG" id="KOG1361">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005260_4_0_1"/>
    <dbReference type="OrthoDB" id="262529at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16273">
        <property type="entry name" value="SNM1A-1C-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12650:FF:000007">
        <property type="entry name" value="DNA cross-link repair 1A protein, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000038">
        <property type="entry name" value="DNA cross-link repair protein pso2/snm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011084">
        <property type="entry name" value="DRMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240:SF6">
        <property type="entry name" value="DNA CROSS-LINK REPAIR 1A PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240">
        <property type="entry name" value="DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07522">
        <property type="entry name" value="DRMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA repair metallo-beta-lactamase" evidence="7">
        <location>
            <begin position="751"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="104"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="355"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="62"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF17282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="911" mass="100137" checksum="0D226BC29F410BB7" modified="2013-06-26" version="1">MFRKPRESLHVELGRRPTSPPTGDTHAVPPPSSMRKPDSSAMSARIRSASKPTPLPTIGRQGPSSTSKKSGTPKNKLGSKGNASILSFFKKSDDGGAAELGLFVEDRRSSTTVGSPAARGDHASVAATEDYAEDHADGTDGLRFNEHDGPVKRRKMSTDEAPEVGTRPSTPAVKPRSRRIGPFYEESDSELEEEAPMAVTGAGQHSGSGMGADNTPLQEEASEEASARPLASGEQCDGPALIKQETSFDPGLDEFDEFGDGDFDEDQFEGGDEYRERRYMEAQARFEAEHDEKDYDPLPSDINVKSETVDHITDGPGEAPPCPICGISLDGVSEEQAGVHVNKCLDGNCTPLPASVNRQQHIPPSDVPLKSEESSSVTQYRRPVRPPRPGQANPFSLGEPDAKAVGGGSAFNKLMSSHTEETAWAEAAASESAARGKPSYQRTCPFYKILPGLFICVDAFRYGAVQGCQAYFLSHFHSDHYIGLTSTWTHGPIYCSKVTANLVKQQLRVDPIYVVPLEFEQQVEVPGTRGVKVTMISANHCPGSSLYLFEKTLGVKQNGEARAQRILHCGDFRACKMHIEHPLLMPDVLDKVSGKTKEQKIDVCYLDTTYLNPKYAFPDQESVIKACADMCVCLSKDTADADDGWETMKRQRAGEGMTKFIQREASNLEVEQDSEDATAADSMTVEKNPHASQQIISSLKDKKARGRLLVVVGTYSIGKERICLGIARALNSKIYAPPSKQRIVAALEDAELEARMTKDPKEAQVHMTPLFEIRADTLDDYLKDFWPHFTRAVGFRPSGWNYKPPKSRFTDSPLVSTVLQSDNWKSTYSMRELVPQRGSSSRASCFGVPYSEHSSFRELTVFCCALRIDKIIPTVNVGSAKGRERMKAWCDRWAAERRKNGPYKILEGDKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1QMB2</accession>
    <name>N1QMB2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_103885</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764635.1">
        <property type="nucleotide sequence ID" value="XM_016900520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QMB2"/>
    <dbReference type="GeneID" id="27897657"/>
    <dbReference type="eggNOG" id="ENOG502QZI3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036934_1_1_1"/>
    <dbReference type="OMA" id="TKVRCYG"/>
    <dbReference type="OrthoDB" id="2590011at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.100">
        <property type="entry name" value="YAP1 redox domain. Chain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF6">
        <property type="entry name" value="AP-1-LIKE TRANSCRIPTION FACTOR YAP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="149"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="47"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF16514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="394" mass="44458" checksum="0914FD22955C6BC8" modified="2013-06-26" version="1">MATYNSQVHTMPHGLPNAQTDHDVYGPGSASSDSKSPLSLNFLKNLNPDKKQTKDGQPPKRRGPKPDSKPALTRRQELNRQAQRTHRERKEMYIKALEQEVLRLKEIFAETARQRDAFHDENRRLKELLQQHGITYDFGATPIKFQRENSGYGASSSGSISGSYQGTSESTGFSPPAMSSHMRPPQAMSAMQTGQMRSMAQLPNNRLDYDSIGIDFVLTLERPCMDHMQYLLVRSHNPDGQEMHHPMENPDDSQHEHMSGHALMGSAAPWSHIKEKPTENYPHQMPTDISNDTLAKLLDLSARLPIDREGEITPVMAWTMIYTNDRIRDLDKLDLERLKTNLTPKVRCYGFGAVLEEFEVRDALNTILAEKDIVPAMSTAMPTAMFVPQAQGVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1QMH9</accession>
    <name>N1QMH9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_160077</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764770.1">
        <property type="nucleotide sequence ID" value="XM_016907879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QMH9"/>
    <dbReference type="STRING" id="692275.N1QMH9"/>
    <dbReference type="GeneID" id="27905016"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_0_5_1"/>
    <dbReference type="OMA" id="MTWIACA"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000061">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF134">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="461"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="490"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="556"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="110"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF16649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="592" mass="65798" checksum="6DA8626C32273A68" modified="2013-06-26" version="1">MAASNLSTDQLDDLENEKSDGGVRTQTRRQSQKDSESSSGHDDSDIHPRDQEIQWKYLEFETELPQPAHLSSRPQARRDDSRTQPPPPDPPDLKNYESPFLWSERRKSLMTWLSCIVTLFVAYNAAAYTSGVDQMMAEWNISRVAALVGVTTFTAGFGVAPMFLAPFSEINGRRPVFVATGLLWVVFQIVCGVTPTFAGMLICRFLAGCASSTFSTMVGGVVSDIYHAKDRNTAMTLFTSGALTGTGLGPLVSGFIAQHTTWRWIFYLQVIIDGFLMILIVFFFKETRGSVLLSRKAQKLNQYYDALEAAGYYGVVIDDESANSSSSSSGGDPEKQQHQPQRSIIRMRWKVLADEERSSLATMLKISLFRPITMLFTEPVVFFFSLWISFSWAVLYLSLAAVPLIFTSTYNFSQQQTGAVFSATCISSILFTVVAIYQETWLTPHLPAHHQKIFETPEGRLYFACAESALLPLGCIWFAVTGAYPQIPWIVPTLGLACATIGIFSIYLAVFNYLADSYHRYASSALAAQSFCRNLMGGSFPLFTTQMFHTMTFQGAGGFLGGIGFLLTIVPWVLLLYGPKIRAKSRLAREII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1QMS6</accession>
    <name>N1QMS6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit H</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_146629</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase H subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765793.1">
        <property type="nucleotide sequence ID" value="XM_016903776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QMS6"/>
    <dbReference type="STRING" id="692275.N1QMS6"/>
    <dbReference type="GeneID" id="27900913"/>
    <dbReference type="eggNOG" id="KOG2759">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025709_4_0_1"/>
    <dbReference type="OMA" id="HSGHLRW"/>
    <dbReference type="OrthoDB" id="10263554at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000326">
        <property type="entry name" value="V-type proton ATPase subunit H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.150:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.150">
        <property type="entry name" value="V-type ATPase, subunit H, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004908">
        <property type="entry name" value="ATPase_V1-cplx_hsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011987">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038497">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11698">
        <property type="entry name" value="V-ATPase_H_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03224">
        <property type="entry name" value="V-ATPase_H_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF032184">
        <property type="entry name" value="ATPase_V1_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase V1 complex subunit H C-terminal" evidence="6">
        <location>
            <begin position="361"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR032184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF11698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF17672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="482" mass="53921" checksum="AB2DA6DB60087C0E" modified="2013-06-26" version="1">MSIDPPAYIVSLQNNIRARPISWEGAVRAKTITDEQLKNIKAIDKVRKEQRKQTIEGDVQTYTDLLLGNGQTKSIFESAAKRTDILQYMLVLTGDIVDDIPVLTESLAKHAHPYKPLLPLLKQSNNPEDPIPLLTSAVLASLMSFALIAQPKSTPDMDEALPTLYSYIAELAKASDSNLQDIAVQHYSALLRTSKSRQQFWKQRKETLGPLMEVLHSATGGKDSDSTMYNGGSTAASIRSMPESIKISGVGLQLLYHILMVIWQLSFEGALVGPGLDEEHDIVPLYTQLLRISPKEKTTRLLLGTLNNLLSSNKSTLMPAALPARLPAVLTNLKGRHLTDEDLLEDLESLKVMVEEYTKTQTTFDEYAAEVHSGHLRWSPPHKNEAFWRENAQRIIDEEKGAICKKLAEIMGKDWANDKQVLAIGCSDVANLVKVCPEKRAQLEKFGLKTRVMSLMQDESETVRWESLRAVGEWLRYSFDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1QMU4</accession>
    <name>N1QMU4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_27932</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765479.1">
        <property type="nucleotide sequence ID" value="XM_016908435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QMU4"/>
    <dbReference type="STRING" id="692275.N1QMU4"/>
    <dbReference type="GeneID" id="27905572"/>
    <dbReference type="eggNOG" id="KOG3138">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_5_1_1"/>
    <dbReference type="OMA" id="ICCRLET"/>
    <dbReference type="OrthoDB" id="47374at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051556">
        <property type="entry name" value="N-term/lysine_N-AcTrnsfr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919:SF8">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="8"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF17358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="185" mass="21038" checksum="D6137FCD55D797BB" modified="2013-06-26" version="1" fragment="single">RRPLPPNVELRSCTKDDLPHLKRLTNLLLPIPYPDKFFKEIIDDPVTASITLLAFWHDDPSLSTTTKGRLVGAIRCRLLAPTSLSSGLHSKEPEAPMLYLSTLVLLSPYRQHGIATHLLRTLTQRAVLDYGVTRVGAHVWEANADALEWYRKRGFQETRRDSGYYRRLNPQTAIIVERKVGVTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>N1QMU8</accession>
    <name>N1QMU8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_138059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765484.1">
        <property type="nucleotide sequence ID" value="XM_016902861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QMU8"/>
    <dbReference type="GeneID" id="27899998"/>
    <dbReference type="eggNOG" id="ENOG502SG32">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_193149_0_0_1"/>
    <dbReference type="OMA" id="NYKPTEH"/>
    <dbReference type="OrthoDB" id="5279375at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF17363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="81" mass="8127" checksum="DD17684CE6522ACB" modified="2013-06-26" version="1">MSDYKPTEHDGLRKDGQPDQRVGTGEFAQGKVDPVEAGKKGGNTSGSGSSEESADSGSSGKGQFAGGKVDPVEAGRKGGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1QN96</accession>
    <name>N1QN96_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein BTN</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_146208</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Vacuole membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the battenin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765235.1">
        <property type="nucleotide sequence ID" value="XM_016903517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QN96"/>
    <dbReference type="STRING" id="692275.N1QN96"/>
    <dbReference type="GeneID" id="27900654"/>
    <dbReference type="eggNOG" id="KOG3880">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029663_1_2_1"/>
    <dbReference type="OMA" id="WLCNWQV"/>
    <dbReference type="OrthoDB" id="5965864at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903826">
        <property type="term" value="P:L-arginine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015819">
        <property type="term" value="P:lysine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003492">
        <property type="entry name" value="Battenin_disease_Cln3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018460">
        <property type="entry name" value="Battenin_disease_Cln3_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981:SF0">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02487">
        <property type="entry name" value="CLN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015974">
        <property type="entry name" value="CLN3_BTN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01315">
        <property type="entry name" value="BATTENIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="367"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF17114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="445" mass="48776" checksum="64EB32605DC66D3D" modified="2013-06-26" version="1">MLPMHLQRAKLRLMSKFDGLSSRVVTAFWLFGLINNVFYVIILTAALDLVGPSIPKATVLAACIVPGLATKVVTPYIIHLIPYSLRVCLFVGLASCGMLLVALTPNSTDAASMTSKIAGIVLANISSGAGEVSFLALTHFYGHSSLAAWGSGTGAAGLLGAGVYTLATTTFGFSVHATLLSSCVLGIVMLASYFILLPLDPLRKGYRKDQYQRVAAEEEDLLNRAAASLHPTLLEEHSERSASPAYQHGGGAKNWLSEGLRDLKIKYMHARGLVIPYMMPLFLVYLAEYTINQGVAPTLLFPLEHAPFKEYREFYPVYGTIYQLGVFISRSSLPFVRIRSLYIPTWLQVLNLGLLTTQAIWPFIPNVWFIFLIILWEGLLGGLVYVSTFAAVREDVPEDEREFSLGAVTVSDSAGIFCASLLGAGMETALCRWQVNHGRNWCRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNI3</accession>
    <name>N1QNI3_SPHMS</name>
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        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_33096</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765904.1">
        <property type="nucleotide sequence ID" value="XM_016908527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNI3"/>
    <dbReference type="STRING" id="692275.N1QNI3"/>
    <dbReference type="GeneID" id="27905664"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_5_11_1"/>
    <dbReference type="OMA" id="WKHQRRT"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000051">
        <property type="entry name" value="Cytochrome P450 monooxygenase (Fum15)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF227">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="1">
        <location>
            <position position="504"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF17783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="564" mass="62771" checksum="418289F8F4796B0F" modified="2013-06-26" version="1">MALLPRVTALAAALTFLITRYTTYSLTPFATFPLLFSILFLLYQLYSILVWPHYISTLRHLPQAPNAHWFWGQTKRVLAEPSGRPMRDWVQNVPNQGLITYSVWFQQRVLITTPAALGEVLVTKNYDFVKPWHFRNGLGRILGIGVLLAEGEEHKIQRKNLAPAFAFGHLKRNIVPIFWSKAQELVDCLANVSTAAVDKKHVSDTDNTNLENAAAEHVHGAVDVGNWTSRATLDIIGLSGMGQDFNALQDPDNKLHQTYKLIFNPGKAGRMLQVLAIFLPSWLTRNLPIKRNQELNAASAYIKQVCRDLIAKKRTVLAEKGVEDVDILSVALGSGGFQDHELVNQMMTFLIAGHETTATAMIWSLYLLCKHKSIQTTLRAEIRSRIPSLSSPITAAQIDSCDYLQAFCTEVLRLWPPVSLTLRVADRDTSIQGQFIPRGTTIILAPAAINTCTHLWGKDALEFRPERWLKSNKSQSGNGGEEGKRGGADSNYSFLTFLHGPRSCIGQKFSQYELACLLAAWVGRYDTSFEKGSPLAHGEPEIKGGITAKPKGGLWTTLEEVPGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNJ3</accession>
    <name>N1QNJ3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UPF0103-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_153661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MEMO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765929.1">
        <property type="nucleotide sequence ID" value="XM_016907518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNJ3"/>
    <dbReference type="STRING" id="692275.N1QNJ3"/>
    <dbReference type="GeneID" id="27904655"/>
    <dbReference type="eggNOG" id="KOG3086">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038085_0_0_1"/>
    <dbReference type="OMA" id="MHLPYIH"/>
    <dbReference type="OrthoDB" id="417112at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07361">
        <property type="entry name" value="MEMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00055">
        <property type="entry name" value="MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002737">
        <property type="entry name" value="MEMO1_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04336">
        <property type="entry name" value="AmmeMemoSam_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060:SF0">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01875">
        <property type="entry name" value="Memo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF17808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="336" mass="36565" checksum="8BAF89137348CB1B" modified="2013-06-26" version="1">MSNNQTVRHASHAGSWYSSSKSQLDGQLEGWLSAVKPPVSCIGPQSAGQTYSELPVPGARVIIAPHAGYSYSGPAAAWAYQAWDVSKAKRIFLLGPSHHYHLTKAALSRCTHYATPLGNLVVDKDTTAKLHASGQFQWMSQSVDEDEHSLEMHLPYIYKMLSKTFGDDPTEFPPLVPIMVGNTSQSTERSLGRILAEHLADPTNAFVISSDFAHWGSRFRYTYYKPSTGSAVDLKSSGPVPTSPAIHESIKAVDFECMEACESGSHERWLHALEDTGNTVCGRHPIGVIMAAVEEVRKSGGKEGIGAFKFVQYDRSSLVIRVSDSSVSYASAFAVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2023-02-22" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNZ2</accession>
    <name>N1QNZ2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_113840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765985.1">
        <property type="nucleotide sequence ID" value="XM_016901056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNZ2"/>
    <dbReference type="GeneID" id="27898193"/>
    <dbReference type="HOGENOM" id="CLU_1125122_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF17864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="247" mass="27119" checksum="79517AC3D5917F68" modified="2013-06-26" version="1">MLLYTRKTTDRSSTTYSLPTQTHHKLTELCTPITDPSADAYAVAQFDAAVIGRRVPITPDSAVKREDGNVGAALYATYNDENVYGHSSPYIKEAGEKVKREDGNVGTALYAAYNDENVYGHSSPYIKEAGEKVKRAEGNVGTALYKALSDRNVYGRLTPYIQEAGEKVKREDGNVGTALYAAFNDENVYGHSSPYIKEAGEKVKRAEGNVGTALYNILADYVYGKLTPNIKEAGEKVKRAEEKRAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M3AWI9</accession>
    <name>M3AWI9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PAN-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_118422</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759236.1">
        <property type="nucleotide sequence ID" value="XM_016901429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AWI9"/>
    <dbReference type="GeneID" id="27898566"/>
    <dbReference type="HOGENOM" id="CLU_507309_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006583">
        <property type="entry name" value="PAN-3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08277">
        <property type="entry name" value="PAN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004031864" description="PAN-3 domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="PAN-3" evidence="3">
        <location>
            <begin position="124"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="379"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="402"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF11115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="537" mass="54510" checksum="A4B2A127388736D6" modified="2013-05-01" version="1">MRQADGVAAASLLLLLLPCILAQQITSTISIPYCSTSPGLFTIYGSMTSAIPSNILSSNSQTPTAGLLSSSVSSVATPLASAYVDQYGGKYTVQFDTGLVGSTIPASRIDGLRKRQAIDIGTLDQTFEDCLESCTLTSACVAVAALDSTCQLFSSVRETVSLVGGKVAFNQERFLGFSNGTILPSSMATEASSAQGMASASAISSGGFRSSMPGLASMPGGSMTPLSQLPSTLAMETSTAGPLVSSFVTQDISPAGSSSDIMPSAALSTNTVTTILSSGAVLSATSEPLSTFSSAGDPTITLQVPSSLSTESSVSISSTSSTPTDQLVSTMTSDGEISYSTDLTITSSLSSLATPASASISSAASSSLALSSVASVSSSRSRAESSSSSSSPGPINASTFFSSPAVPTTTRTTTTTTSSSSSSSSPATPTSSRKPPTCPDDDGEDYIDTNGFIYIITCDIGFNDETIQTTTVQNFVDCITTCDAFNELPKDDEEVMGCGGVNFNSLAQTDNCLLMPGAEIAEMAGIWSAQLSGSIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M3AX00</accession>
    <name>M3AX00_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7703 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_47891</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759376.1">
        <property type="nucleotide sequence ID" value="XM_016909046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AX00"/>
    <dbReference type="GeneID" id="27906183"/>
    <dbReference type="eggNOG" id="ENOG502SIDK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045148_2_1_1"/>
    <dbReference type="OMA" id="NCAIIAM"/>
    <dbReference type="OrthoDB" id="405906at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056120">
        <property type="entry name" value="DUF7703"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G05950)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G05950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24802">
        <property type="entry name" value="DUF7703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7703" evidence="2">
        <location>
            <begin position="35"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF11255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="363" mass="40145" checksum="5610E45590879671" modified="2013-05-01" version="1">MVSVDGNASNEASWTSPGVGITAGYDGNSETFRIFIVFFLGLGIYNACVIIASALFYFKHYRGLYFWSLVTAGWGIIPYCVGFLIKFMNIVTGKGIWIAAVLVTMGWYPMITGQAVVLWSRLHLIVSGQRGDRILQWTKYMIITNVLILHVPTSIMAAGAQGTIRTTTFARGYNIIEKVQMVGFFLQETILSSIYITETVHLLRSSSQAGGRQQRRTMQQLIAINVTIISMDLVLLGVEAASLYILQILLKGLVYSIKLKLEFAILTRLVSIVPDGSTGPLNFITSKDNMEVPIEEIVDFGKINSDITHAATPTMGPGGRLRRNSELDVEIARFEHVHKGALWSESGAQQHVRYADDVGLEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-09-13" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>M3AYC7</accession>
    <name>M3AYC7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_149170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760638.1">
        <property type="nucleotide sequence ID" value="XM_016905385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AYC7"/>
    <dbReference type="GeneID" id="27902522"/>
    <dbReference type="HOGENOM" id="CLU_2414693_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004031557" description="Secreted protein" evidence="1">
        <location>
            <begin position="37"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF12517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="92" mass="9860" checksum="6F3ABA4F56294A55" modified="2013-05-01" version="1">MALLICFPGSCPPSLSAMALWCLLLCLPSLQRRCCGAGDGRRAKTAIALIALAGMDYACRHLLLCNCFVHVDTVRCVLALPWSRLGVGEIPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M3B004</accession>
    <name>M3B004_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_148498</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761238.1">
        <property type="nucleotide sequence ID" value="XM_016904958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B004"/>
    <dbReference type="GeneID" id="27902095"/>
    <dbReference type="HOGENOM" id="CLU_2185595_0_0_1"/>
    <dbReference type="OrthoDB" id="10465713at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004031956" evidence="2">
        <location>
            <begin position="17"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF13117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="109" mass="11781" checksum="9E8F59CC44378B03" modified="2013-05-01" version="1">MKVAAIISICAAASLAAPVADDYIPGHYRPTRTYNTGVEASAIPQASAIPQASSIPKPQVSNIPVSPQVSNIPSGYQSKTVSAPESKIWVGEQVEHSKPEEWWERHEWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M3B0C2</accession>
    <name>M3B0C2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_116295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EMF13237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016901243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B0C2"/>
    <dbReference type="GeneID" id="27898380"/>
    <dbReference type="HOGENOM" id="CLU_2814054_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004031251" evidence="1">
        <location>
            <begin position="18"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF13237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="67" mass="6938" checksum="CA4EA99B53FBC346" modified="2013-05-01" version="1">MKFTAAIFATLLSLATAVWQCDQKVFAEGVCVNRGVPGDVQQCSASAKCTANNNSCEPLGPGKAKCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M3B1M2</accession>
    <name>M3B1M2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Histone deacetylase interacting domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_148918</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761823.1">
        <property type="nucleotide sequence ID" value="XM_016905226.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.M3B1M2"/>
    <dbReference type="GeneID" id="27902363"/>
    <dbReference type="eggNOG" id="KOG4204">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001360_2_4_1"/>
    <dbReference type="OMA" id="MCEEVIK"/>
    <dbReference type="OrthoDB" id="10265969at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000001">
        <property type="entry name" value="Paired amphipathic helix protein Sin3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000002">
        <property type="entry name" value="Paired amphipathic helix protein SIN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000003">
        <property type="entry name" value="Paired amphipathic helix SIN3-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1160.11">
        <property type="entry name" value="Paired amphipathic helix"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013194">
        <property type="entry name" value="HDAC_interact_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003822">
        <property type="entry name" value="PAH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036600">
        <property type="entry name" value="PAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039774">
        <property type="entry name" value="Sin3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031693">
        <property type="entry name" value="Sin3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346:SF0">
        <property type="entry name" value="SIN3A, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346">
        <property type="entry name" value="SIN3B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02671">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08295">
        <property type="entry name" value="Sin3_corepress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16879">
        <property type="entry name" value="Sin3a_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00761">
        <property type="entry name" value="HDAC_interact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47762">
        <property type="entry name" value="PAH2 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51477">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase interacting" evidence="9">
        <location>
            <begin position="774"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="361"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="592"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1062"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1507"/>
            <end position="1551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="127"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="237"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="384"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1113"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1511"/>
            <end position="1523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF13702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1551" mass="172357" checksum="70A4671E8B5ED02D" modified="2013-05-01" version="1">MDPGPHRSWPPPHQPGGNGHANDNNQHQGHSQPPRPGPPFGPGTPQHNPQQSPPHAPSALPPPGGPFASFHSAPHSLASLAGLSQQSPRQPPTQAHRSDERPPQPPQGPGFALPGLGQVTGQPSVAEQRDRERAREAEHIQIKEEEDRRHREIERQRMEQAPLHQSQQGPPPHLHQPVALPPRTIHGPNGLLGNPNIVGHATQQQQHPQLGAPQGPPNVFGGGPVQQSQPPPPQQMPPGLLAPYGPGAQAPQPQQQMAQGQQGQGQQPILNDALSYLDQVKVQFADHPDVYNRFLDIMKDFKSGAIDTPGVIGRVSTLFAGNPELIQGFNTFLPPGYRIECGADNDPNSIRVTTPMGTTVQAMPRAPSRNGVTDGHRPGDGGSFTPQPGTAQMAFSPSGRPVGPVAPGHQNLSPAETAARRQAHEDLVTAHTRDQRGMQSLGNAASVTAAGALAGLPAGISPRATPLPMQSAEAIAVDASGMEKRGPVEFNHAISYVNKIKNRFSSQPDIYKQFLEILQTYQRESKPIQDVYSQVTHLFKGAKDLLEDFKQFLPESAAQAKAAERARAHAEAAQLSDMRSTAGDGMYNSPVISREMGTPAHTRGLPPVGNFAPTPASKDNKRKRQGTGPPDNVPGQAGPIKPQYMAGPPGKRSKTNNVVAKNEQPPTSPTLIPSLPAPLPPTTTSVATSDEMAFFDKAKKAIGNKNVYNEFLKLCNLFTQDLIDRRMLLYRVESFIGGNQDLLNWFKNWIGHDERDQIIENKPRVAPGRVMLSNCRGLGPSYRLLPKRERQKLCSGRDELCNAVLNDEWASHPTWASEDSGFIAHRKNVHEEGLHRIEEERHDYDFNIEAASRTIQLLEPIATQLRRRSDAEQRAYQLPEGLGGQSNTIYKRVIYKLYGREKGIEVIENLRDRPYQVIPILLNRVKERLETWKMGQREWEKVWREQTQKMFWKSLDHQAVQAKNVDRRAFQSKTLQSEIMVRYEEMRRAGFSDPILLRKPQLEYTVDDEDVLADATHLVLTHVRTSMDTDHPRLAKFIEDFVPLFFGIDSTRFQALLQNRRSDELDDDLPSAGDDAASVGSRKGNGKNGGLLRAALDPGSRGRKLTGQDREGSQASNSRASTPDAGSNADPDEMAIDSTETPEIKEASTTRWLEHPLEGNLSADGKNVNPLQPQLRSLYRCWANGTLYCFIRLFVMLYERLYKLKCAESSVRKNVKDAGTARPAAELGLIDKMPSDFFSDISDNASYYSQMVVKFEDVLNGTIEFAEVEEALRRFYLQSGYPLYPFEKLVATLAKDATLVMNGDSKDKSAEIFALYRKDRLKEHSTAQQQNDYRKAFEKLIKDNDLYRIDFDQKTSQLAFFVSKREDSIADDGLSALDREQKWRYYIASYTSIDPTIDVDHSAMDMPFLVSNMKTSGADPMAESFSATMNDELNAFQARFLDVKNEERLGLRVAVNSYKTFFTANTYESFHADLRRRQGGEEGVKLGQQTRHLREEVVKDRYELNNGGMRDLSKESVENKNSEFTRLVENGELETGGTEATQQNGDVEMED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M3B2X1</accession>
    <name>M3B2X1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">SEPMUDRAFT_147948</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762258.1">
        <property type="nucleotide sequence ID" value="XM_016904615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B2X1"/>
    <dbReference type="STRING" id="692275.M3B2X1"/>
    <dbReference type="GeneID" id="27901752"/>
    <dbReference type="eggNOG" id="KOG0519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003731_0_0_1"/>
    <dbReference type="OMA" id="WGDSNRI"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007234">
        <property type="term" value="P:osmosensory signaling via phosphorelay pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000004">
        <property type="entry name" value="Ethylene receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000289">
        <property type="entry name" value="Osmosensing histidine protein kinase SLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF72">
        <property type="entry name" value="OSMOSENSING HISTIDINE PROTEIN KINASE SLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 14" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="17">
        <location>
            <begin position="554"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="18">
        <location>
            <begin position="1010"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="417"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="721"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="912"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="725"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="746"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="758"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="912"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="14">
        <location>
            <position position="1066"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EMF14137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1218" mass="132877" checksum="0D415C0A4A93C743" modified="2013-05-01" version="1">MRIPIRIQLGSLLLLSSLIGLAVISIAVWITVHGFVLEIRASRLALTASLKAGQLSSNLDVMHTSASFVTTRVLIQNALQRYNDYRNNTPANWANAAADMAAAIGGEASLGQQLLMQSRVWSKDGAGPAGALPLLDTTPDSVDNTIALPYTYANGSPVYLGANDSDYGYPPLLYPNLTYSVGGPARYGDYALHLNSSLFLGPWFVNSTYALVSLTLPIANNTDRNSLLGYTTILMNAELISQVINSAEGLGRTGETLLIGPANPTNRLPNGMAMKNTEDMPELDIRYVVPVNNSGSKRHPTRTQEGTNSPFSISDFPAVYKAFAATDPSGSRLKATNEAGKKVSVGYAMTTSAMVNWAVLVEMSRSEVWQPIATLRKVIVACLFATACLMALIAFPLAHFAAQPIIMLRAATLRSVDPPSMDGQSEVDFLSDTRDGPADDPVDAGSEVDATMARKEGFRAHISNWKRKREADTQVKREEQRKRAFRIPGRVKQRRGCIKDELSDLTSTFNDMSDELMVQYSRLDERVRERTAELELSKKAAEAANESKTLFIANISHELRTPLNGILGMCAVCMQEDDPLRLKRSLGIIYKSGDLLLNLLTDLLTFSKNQVGQHLTLDEKEFRLRDISSQILAIFDKQAKDGRIDLKVQYEGIADPGTDDASPDMSIYGPDTSGRVSDMILWGDIHRILQVVINLVSNSLKFTPPGGSVRLTIRALSERPDIGSRGTSMTSRQSNSVRIGRPWRQQHAETSDWRRSTQRSSDSAVLNSGPQKHAEMSETPISRQGMHRTSDLSGPRIATANAINARDKPHASLHVSERTRSPSSGKYIYFEFEVSDTGPGIPEDIQDKIFEPFVQGDLGLSKKFGGTGLGLSICSQLASLMKGEMKVRSTVGLGSTFTLKMPIRHVQTRADSAASSVAGVGNDVSREGSLFDSRTASPQRSHGPVEYEGSIPSPSEPVKPRVKEAPTTQSRLVGLSQPYLTTSKPPESPDAKEEAIKRISATTSGSGKIRVLVAEDNKINQEVVLRMLKLEDIYDVVIAKDGQEALDLVKTSMRPGARPFNLIFMDVQMPNVDGLTSTKMIRAIGYQAPIVALTAFAEESNIKDCYDSGMNYFLSKPIRRPQLKKVLKEYIAPILEEPEEEEEAASPPLLGQGNHNTTIVMVNNERRSQDSKGAADITTDKSANAALDNTDQSFFAATVGNLAQADEGFTSPRTAVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M3B477</accession>
    <name>M3B477_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">endo-polygalacturonase</fullName>
            <ecNumber evidence="3">3.2.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SEPMUDRAFT_41070</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(1,4-alpha-D-galacturonosyl)n+m + H2O = (1,4-alpha-D-galacturonosyl)n + (1,4-alpha-D-galacturonosyl)m.</text>
            <dbReference type="EC" id="3.2.1.15"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.15" evidence="3"/>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762713.1">
        <property type="nucleotide sequence ID" value="XM_016908812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B477"/>
    <dbReference type="STRING" id="692275.M3B477"/>
    <dbReference type="GeneID" id="27905949"/>
    <dbReference type="eggNOG" id="ENOG502QTAW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040116_0_0_1"/>
    <dbReference type="OMA" id="NGALYWD"/>
    <dbReference type="OrthoDB" id="1546079at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000002">
        <property type="entry name" value="Endopolygalacturonase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050434">
        <property type="entry name" value="Glycosyl_hydrlase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884:SF1">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00502">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 13 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032031" description="endo-polygalacturonase" evidence="15">
        <location>
            <begin position="20"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMF14592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="421" mass="43611" checksum="0A2D4B5E9D388C82" modified="2013-05-01" version="1">MIYQRTLIALAVGAGLAAARPAPWSAQDSSLDHFTDRFSSPTFPAPVAGGTIVKKSSSKSASTKKPTGYTAKDTGNGTAGSECTFTDIEKAMASKASCPNIVLKDITVPAGKTLDMEDLADGTTVTFEGNTTFEYSEWAGPLLSFSGKNITITGASGHVIDGNGKAWWDGQGSNGGKTKPKFFAAHKLIDSTISGLNIQNYPVQCFSINQAQNLIVKDITIDNSAGDELGSDGKPLGHNSDAFDVGSSTGVHISGANVKNQDDCLAVNSGSDISFTDCNCSGGHGISMGSVGGRTNNEVSNVNIANCTVSDSANGIRIKTVYDAEGSVKNITYSNIKLSNITDYGIVIEQDYQNGSPTGTPTSGVPITDITVENVSGTVADDAEEIYILCASCSNWKWSGVSITGGQKSSKCKGVPDGASC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>M3B574</accession>
    <name>M3B574_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="19">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">SEPMUDRAFT_146934</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 19">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="19"/>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF14907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763028.1">
        <property type="nucleotide sequence ID" value="XM_016903972.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.M3B574"/>
    <dbReference type="GeneID" id="27901109"/>
    <dbReference type="eggNOG" id="KOG0210">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000846_6_0_1"/>
    <dbReference type="OMA" id="IAITTWH"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000067">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000009">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF5">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9 18 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 17 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 19" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1122"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1155"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1204"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1286"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1313"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="21">
        <location>
            <begin position="194"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="22">
        <location>
            <begin position="1092"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="164"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="270"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="418"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="20">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="418"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="16">
        <location>
            <position position="662"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="662"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="662"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="663"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="664"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="664"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="771"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="815"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="847"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="876"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="957"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="958"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="959"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="1039"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="1045"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="1065"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="1068"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="1069"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="1069"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EMF14907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1356" mass="149491" checksum="714F8A82E7D5D3D9" modified="2013-05-01" version="1">MNGYHQPHDQHGAYDDDDGDRDSDLDLDLDLNELDPQPRPSTDGTKTGSRQPSTVRSSYDFGARIPLRNLRFGGRRRARRNEEDAEDLEALVGDDEDDEPQSKPPSAASSGVSAYDDAPLLSRENGGGGLRKFSRAAGLDGLGDNRKRRKGIWRYIPFLTPSSSMQLPATGEDEEKAEDDHDPAATRDVTVGQKQTARFPTNAISNAKYTPWSFLPRTLFNEFKFFFNMYFLLVAMSQIIPALRIGYLSTYVAPLAFVLMITLGKEATDDLNRRKRDREANSEPYKVLRFDTPGSLGGSAGRNKRKIKSISEKKKGKRRRVSHEDVRLQAAEDEEHSTQDVDAPSSEVVEIIKPSAQLKVGDVVVLEKDQRVPADVVILKSFSTDTVALANEPQRHSSDSALRDMGDGATVASSLLQSETANRQDLSNETTSSDPSGGGEAFIRTDQLDGETDWKLRLATPLAQTLPSSEYIRLRVTAGKPDKKVNDFVGTIALEAKQHRAYDPPLDGEEAAIKSTALNIDNTAWANTVLASSTTVHAVVVYTGAQTRAALSTSASRSKTGLLELEINSLVKILCILTAALSIILVAIHGVEEHDGNKWYIDAMRFLILFSTIVPISLRVNLDMGKSVYAWFIHHDAGIPGTVVRTSTIPEDLGRIEYLLSDKTGTLTRNEMELRKVHVGTVSYGGEAMEEVISYVRQAFTFSEDAQPGTLFSPSAAISSLSGATRTRKEIGLRVRDLVLALALCHNVTPTTEEDESGQSKVSYQASSPDEIAIVEWTQSVGLRLQHRDRKRITLQYTGDDRIIVRVEVLNVFPFTSDSKRMGIIVRFIRDTSRSHDEDGEIVFFQKGADTVMTSIVAANDWLDEETDNMAREGLRTLVVGRKNLSAQQYSAFSSAFAEASLSLAGRDAAMSSVVKQHLEQNLELLGVTGVEDKLQPNVKPSLELLRNAGIKIWMLTGDKVETARCVAVSSKLVSRGQTIHTIANLKRRDTALDALGMLHNQTNAALLIDGQSLALYLRYHRDAFISLAVRLPAVIACRCSPTQKADVAHLIRAFTKKRIACIGDGGNDVSMIQAADVGVGIVGKEGRQASLAADFSITQFAYLTKLLVWHGRNSYRRSAKLAQFVMHRGLIISICQTVFSIASRFEPIALYRDWLLVGYATIYTMMPVFSLTLDRDVDENLANLYPELYKEVTLGKSLSYKTFFIWVAISVYQGLIIQGGSEVLVPSFNRSDNNNSSSSSSTTIADSSYAPLQTTGFRKMVALSYSVLVINELCMVAAEITEWHYMMWASIVATAVMYVGSVPFLGEYFDEGFVWSGGFAWRFGAILGAALVPVWGGKVVRRWVRPPSYRKVRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M3B5L6</accession>
    <name>M3B5L6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_79372</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SWD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763203.1">
        <property type="nucleotide sequence ID" value="XM_016910219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B5L6"/>
    <dbReference type="STRING" id="692275.M3B5L6"/>
    <dbReference type="GeneID" id="27907356"/>
    <dbReference type="eggNOG" id="KOG1446">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044117_2_0_1"/>
    <dbReference type="OMA" id="HNEGYIR"/>
    <dbReference type="OrthoDB" id="27537at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037867">
        <property type="entry name" value="Swd2/WDR82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861">
        <property type="entry name" value="WD40 REPEAT PROTEIN SWD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="113"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF15082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="363" mass="40177" checksum="749F0074F0A83265" modified="2013-05-01" version="1">MVPEQQPPNVAKVQDIITTFRPCRLFKAPPPSSYTSIDFDDSGEFLLLSRSDDTVQLFNIKAGQHAKELKSQKYGSALARFTHHSTSIIYASTKHNDDIRYLSMHDNSFIRYFKGHQGRVTSLNLSPNNDQFMSASLDNTVKLWDARSPNAQGQLNFQSPWFTAYDASASVIAIASPPAQTIALYDLRNYDKPPFTTFDLLDLENQFRSHGQRGGEGWIGLEFSNNGKYMLIATNGPGHYILDAFSGDLIHYLQKPTGADYSHYAPGADLLTVPTGEGSTPSFIQSSACFSPDGRYVIGGNGRSANLQVWDCAEEPKADRVLDPCAELPSQKPAKVVAYNPRHNLVATADKEMMMWLPDPDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M3B5M8</accession>
    <name>M3B5M8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_154002</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763218.1">
        <property type="nucleotide sequence ID" value="XM_016907538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B5M8"/>
    <dbReference type="GeneID" id="27904675"/>
    <dbReference type="eggNOG" id="ENOG502R1A2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_507307_0_0_1"/>
    <dbReference type="OrthoDB" id="3632962at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="5">
        <location>
            <begin position="328"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="49"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="179"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="485"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="179"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF15097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="537" mass="60085" checksum="1C39531869F57C3D" modified="2013-05-01" version="1">MASSQVPHYDTMVIIKDEPQDDDFLMPDAAALPTAPTLRVHQGLQTGRHLTVSDNGEPSASKGRQAHPPPPPSSNRAKAPDGGPHNSMCFEEPYLSRPQFHRLICGHDIATVAVERCGANCHPPSRPTGSDQKPDNMRFECPDPQCKRRANVLPSFDQKTRRRKYGRVCVLAHVRGRDSEADKAWDEEKGRQNHHSARTRAARSFGRKTSRSPSPKRGQISGPRGDRPETRSNLMRPNATEQDLGRVRPAVVFSELEIARMGPTQMKKKLSVACYERRVKQSRPVPGPAFTEPEGPSKDWDAVPVGDQDNAEVEAAEEDHAEEEDELHCVCRSSDCQWMVECNRCDEPFHPGCIGKGAHDAAQYELPSRDLLFEFDAKNSTSEFLCLFCEAHGKVEAGIRDQRRKMAEHFKRSELLLQFHSKLMARKQTALDRAQGQEQEDTVTAFFASIEQEMNECGSLQLRDWRALLTKALEVPLAPPRIRKRGAAEVEPEEAGSALAVPSRDNAEPPRKRQAYMEGEEVTLPIIPPKQAPIVRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M3B7E9</accession>
    <name>M3B7E9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_114871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763918.1">
        <property type="nucleotide sequence ID" value="XM_016901115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B7E9"/>
    <dbReference type="GeneID" id="27898252"/>
    <dbReference type="HOGENOM" id="CLU_877629_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF15797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="317" mass="35632" checksum="227E18E04DB19216" modified="2013-05-01" version="1">MPDKTARGTVLIAKDGRLCVLRDSEDDGLVFFQPTPRPGLVPLVDYNGVNRGTKVPGQTYDDLELLEGNAQMIGQAFWKWSNNIGQPERRARRGLIMDVLAMTFERHYGNLKPSPKFQFYAAELTNSNGRAIEVGGKDCQYPYRPPEHRLLHVGDELFKLAVEQYKSFEQVYSGLPTHPTAKAIEEMNRERQRLETTKPAAKVAAVSAKQALFNPSNEEDQDDEETLPASKLEEEAQPEAQACTPAQREGAGVAKIATTPVGAASSVVRSAEGKEDEDMDAEDINLEMRQVELEQRKIRLHQMRRALEKKKRRRKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M3BPF5</accession>
    <name>M3BPF5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_54513</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF08048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756169.1">
        <property type="nucleotide sequence ID" value="XM_016909303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BPF5"/>
    <dbReference type="GeneID" id="27906440"/>
    <dbReference type="eggNOG" id="KOG1611">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_9_1_1"/>
    <dbReference type="OMA" id="CDGMMEV"/>
    <dbReference type="OrthoDB" id="9876299at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05325">
        <property type="entry name" value="carb_red_sniffer_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF7">
        <property type="entry name" value="NADB-LER2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF08048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="253" mass="26946" checksum="EF1D9D5FFA39CD2F" modified="2013-05-01" version="1">MSTTYLISGTTRGIGRGLVSALLLRPNTLVFAGVRDPSAKAAQDLLSLPKAPDSSVFLIKLDSSSESDAAQAIQTLQQEHNITHLDVVIANAGILTTAAPCREVTLDSLRSHFEINTLGPIILFQACLSLLQKSSNPKFVLTTSAVASCTIAPSLPAPVVAYAVSKVAANWFVSRAQGEHPEICFLPIHPGLVVTDMSSSFMEHAAEPGSGDDFLRAISVEECVKGYLQVVDKATKEKDGGKFVQWDGEGLPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M3BR16</accession>
    <name>M3BR16_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_152189</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756684.1">
        <property type="nucleotide sequence ID" value="XM_016907291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BR16"/>
    <dbReference type="STRING" id="692275.M3BR16"/>
    <dbReference type="GeneID" id="27904428"/>
    <dbReference type="eggNOG" id="ENOG502RJN1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012741_0_0_1"/>
    <dbReference type="OMA" id="AGSGKWF"/>
    <dbReference type="OrthoDB" id="5372451at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="608"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="630"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF08563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="749" mass="82579" checksum="8D24F9D5CF5C134C" modified="2013-05-01" version="1">MMAPNPIMIRRKPVRQSIYEEPTRRHAPAPGRGYPVPVSVLSSAFVLLLLATVSWSRRWTVSGAAVESVLLVCGSGQQKRILSAIPLWTLLATLNLVYAICSTSWLLYGLFTIAIYPFILLTCLNQFPRAANMARAGLRKVLGSQPHFVKDKLGMFDLPALEIDTTVDGLFVIRGVTMSFSTLTLVAHGMELGLKLADDIELAIYVDEVTVSFFRRIEIGDVYANAKGGKFEMTFGDLEEDSDDAASEFSVLLDDTPLLKAAAAKSKGLLDRPKLRETLTGVSFMRDSSLQQVADHIQTMDPENEAANQQYQDKLTEIRTSSAVYQSRQRARQKAKSSGRKMDDEKDMRAAVCAELQELPAVPHPPRRSIRVTTLQNSSPEYVRRFLHRLPFLLRALLAPLSYFHTVSVSSVNAAGSGKWLSTLLQQQIFKEYTENNASLRRLQRKVSTWLADANFCVQLTDIDGMGSVPWSTAYNIVTYLKFDDVVAFRTMPESGVSSQVLRLGGADATFSIPSYLLPHHEHIVPPKPTHEAEHELEEEMHEADGTPKTVQAAHDLKRLQKDETNIELSVHGSLPVACDQSLLNFIASLVKATKMIELEKTVAEVQAQPVDSPMSPLSPTFDNNDDSESVSSLPSKANSDNRSETNVSIKEVAGFKVFAKHIRQNLKDGTTKAQIKDFAKDLHQNAKDGMKKAAVGGLVNDRWIAVLVGKVAAGLQKAQGDVGYSGSIPIPLAPYRNTEHGDLAKILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M3BRQ0</accession>
    <name>M3BRQ0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_92934</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756914.1">
        <property type="nucleotide sequence ID" value="XM_016910599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BRQ0"/>
    <dbReference type="STRING" id="692275.M3BRQ0"/>
    <dbReference type="GeneID" id="27907736"/>
    <dbReference type="eggNOG" id="KOG2604">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011639_0_0_1"/>
    <dbReference type="OMA" id="DEFELWG"/>
    <dbReference type="OrthoDB" id="296793at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048685">
        <property type="entry name" value="COG3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048320">
        <property type="entry name" value="COG3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007265">
        <property type="entry name" value="COG_su3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13302">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13302:SF8">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20671">
        <property type="entry name" value="COG3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04136">
        <property type="entry name" value="COG3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 3 N-terminal" evidence="10">
        <location>
            <begin position="111"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 3 C-terminal" evidence="11">
        <location>
            <begin position="277"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="16"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="430"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="507"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF08793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="841" mass="94526" checksum="35CDFCCFB6CEB00C" modified="2013-05-01" version="1">MDDAWFHTLTAAARDKPSQHTRRASLLQQPDDDAWSGPPRASCARRAQSYSDFYHRVQGDNEKEGHRERHNSLDTSHPVVLPQCAELDFAAEYDAIEELLMNESHAEYQAYLEQLELSDGHLDNLLVSTTSTLDLLSALSDSFQAVAVQTEAFRQQCEDIVLEQRRLTGLADAIDENAQYYAYLEPMTRRLNAPGASNLVKGKDFLEMLSNLDNCLAYMELHPTHKESATYRSRYRLLLTRGLTLIRHHFTKSLGEIAADISKRIHGGQLKETTHSTILYAKFRAPAPELKALGLEIQKRAVPTPDDVDAGREPEYLSLLRELYQSYSATRGRLILPLVAKKMADLAADPQHVDVLSFAKSSLSYVRGICLDEHDLWFEWFETEGALYDFLESLLEPMYDYLRPRTIHETRMEKLCDLCAMIQGRYMDVDSEEDDDTESSAASPSTSGRQLGRKLDFGNLIHPALEDAQTRLVFLALNVLRDSIENYKPKAEDLEVSPRAAITGINGAKKGPVLSGKRQPSTPSTPIPKTPAVVDEDIDDGESMFSKRFAVETSTPSIRHWYPTLRKAVWLLRRIYRLVNSTVFDDLAHRIVHSTIASLIYAGQQVSSKRTPQDGQLFLIIHLLHLKQQIVAFDIEFIPPEVEFDFSSVTNTFYELRDRGSLWNPASWVRLVGGAVGGGLLPRVVENMLDAKAELDGRLRTVINDFVKGYASHITAPVEGVAVAQAQEKKEFDGVKAVRTVRGLAEKDVPALREKLEEFVDDARTRETLVAAVRDQVIMSYEEFFDNYSEGRGKKLSRKGKGREDEVWGPDLFNDAMEKVFQVGQVVGEDNDSVGSGGISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>M3BT17</accession>
    <name>M3BT17_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_119550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF09810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757931.1">
        <property type="nucleotide sequence ID" value="XM_016901520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BT17"/>
    <dbReference type="GeneID" id="27898657"/>
    <dbReference type="HOGENOM" id="CLU_2672691_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF09810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="75" mass="8649" checksum="40B56366EC7FB1B6" modified="2013-05-01" version="1">MDDATFNKVKEENKKQVQDVLARQATIIKNNESLIVPFTRETLKEAASLHDNEPDRERFVRESLMGFWLSLGLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M3BTH7</accession>
    <name>M3BTH7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CobW-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_70924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF09950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758071.1">
        <property type="nucleotide sequence ID" value="XM_016909921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BTH7"/>
    <dbReference type="STRING" id="692275.M3BTH7"/>
    <dbReference type="GeneID" id="27907058"/>
    <dbReference type="eggNOG" id="KOG2743">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017452_3_0_1"/>
    <dbReference type="OMA" id="QEEFFPV"/>
    <dbReference type="OrthoDB" id="259708at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03112">
        <property type="entry name" value="CobW-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051316">
        <property type="entry name" value="Zinc-reg_GTPase_activator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748:SF62">
        <property type="entry name" value="COBW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748">
        <property type="entry name" value="COBW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW/HypB/UreG nucleotide-binding" evidence="1">
        <location>
            <begin position="6"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="360" mass="39374" checksum="8A88D5769F6B3F6B" modified="2013-05-01" version="1">MASRIPITILTGFTGCGKTTLILNLIPQLRQHNPGYKLALIKNEIGDVAIDSQLAQSAEMAATQELLGDCICCVNVGQIGTALEELDSQSHPDRIIIETSGSAEPLKLVLEIKRLSEATGRYELDGIVSVIDAENWAGYASKSFTAKLQAKQTDLIVINKWEALGERAYDLFLDKLGDLDVDTPQVKSDKGWVEKDLLFGFDQKLARNWLDVHDGGHSHAHGHDHGDGEKHTSEVECLSVTLNASSGDAVVDLPKLETLLKAAPKDEVYRIKGVVYSASSPKNADGKDVNGGASGRARYILNWSFGRWTWYHIEDDGSDAPVARISIFTAPYESTKWSKNANEFVKLQDGAGDLEVKRVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2022-12-14" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>M3BVH7</accession>
    <name>M3BVH7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_118622</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759445.1">
        <property type="nucleotide sequence ID" value="XM_016901442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BVH7"/>
    <dbReference type="GeneID" id="27898579"/>
    <dbReference type="HOGENOM" id="CLU_2251747_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF11324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="104" mass="11818" checksum="0D3D53A8A9FC1F78" modified="2013-05-01" version="1">MTNQDEVPPQAHIGHPTIHIRLIGPVALIHPIHAPTRAQLTPAGDLLHPHDHMNIFNISPLSKFDHVHWEHRMPLPKPKVELVQGRLGDFARCQHNVFTLGVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M3BVS3</accession>
    <name>M3BVS3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pre-mRNA-splicing factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_69028</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in mRNA splicing where it associates with cdc5 and the other cwf proteins as part of the spliceosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Belongs to the 40S cdc5-associated complex (or cwf complex), a spliceosome sub-complex reminiscent of a late-stage spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWF11 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759545.1">
        <property type="nucleotide sequence ID" value="XM_016909848.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.M3BVS3"/>
    <dbReference type="GeneID" id="27906985"/>
    <dbReference type="eggNOG" id="KOG1806">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001195_0_0_1"/>
    <dbReference type="OMA" id="YRVWLDC"/>
    <dbReference type="OrthoDB" id="1879at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17935">
        <property type="entry name" value="EEXXQc_AQR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002863">
        <property type="entry name" value="Pre-mRNA-splicing factor cwf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048966">
        <property type="entry name" value="Aquarius_b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048967">
        <property type="entry name" value="Aquarius_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032174">
        <property type="entry name" value="Aquarius_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026300">
        <property type="entry name" value="CWF11_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF5">
        <property type="entry name" value="RNA HELICASE AQUARIUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16399">
        <property type="entry name" value="Aquarius_N_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21143">
        <property type="entry name" value="Aquarius_N_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21144">
        <property type="entry name" value="Aquarius_N_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038901">
        <property type="entry name" value="AQR_cwf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="1 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="2" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="1 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA helicase aquarius N-terminal" evidence="6">
        <location>
            <begin position="14"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="RNA helicase aquarius beta-barrel" evidence="7">
        <location>
            <begin position="478"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="RNA helicase aquarius insertion" evidence="8">
        <location>
            <begin position="695"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="4">
        <location>
            <begin position="801"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="5">
        <location>
            <begin position="1112"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="717"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1374"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1390"/>
            <end position="1402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR038901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF21143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF11424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1414" mass="159985" checksum="CACF116310386568" modified="2013-05-01" version="1">MARPGISDLTGDHRIAQIARDTWLSSPSSAPKVLPATITELWQLVEEDDSPFSLLLLEQLQALERYLWPGYTDNASNHHVLLIVLLVNTKRSENLPTWPLFTTTPDEFADFFRRVLHLSIDSSLATNVREYLLAFIVGAYQSLDHGVVRKECAPLVSIGIWHNLHSDAARQRRLAKSAQLQKAWRASGKKFDNADPAGQARMRFERSWLYLLVLSFCDKLYTSTKKEDDVAYCERFLELLCDLQSQLPTRRYVNALLQDLNILPAIALSPLHQQESRIREFYELLVHYTHFPIDDQTGRQLSRQEYQESQNASISRLQKVGMRLQPEKLKIMILTNFGALGQREELESHLKDLSDDELLELCQSVGLRTREYPETTQLVQDRAFLVETLVAMVESKPYYTERMRKLQILPTEHALYSNARLPSDEHVVNQPLAIPKLNLQYLTIGDFLWRSFTLYRYEAFYSLRKHLEDTIKRLQPRRGGGIVRFDGFSRMAIPIPKPALIETAAPRVGEIVPAQVKAEIILDVSRLQPGLRREWESLRSDDTVYLLALQPEDNAHKLTNGAAAKQSVAERLGLKAVRCAEVISVLDENSRALRFNQHDQDYTDNGPRPRQRRLLLRLDAASYKADKDREASGKPDIYESINLVVRRKSRENNFRPVLESIKQLATSDAPVPSWFEEVFLGIGDPASATYKRLANKLQSVDYRDTFVDWQHLIESLPGKTVEPDPDLDSIPPPPYVLENTGSAPAPPPAKGKKRRRDQPDGPDPKPTAETYRVSTYQPPNSGPYPEDAPKLNHVRFTPTQVEAVTAGTQPGLTVIVGPPGTGKTDVATQIISNVYHNFPQQRTLLIAHSNQALNQLFQKIVALDIDERHLLRLGHGEEELMTEASFSKAGRIESFLERGARYLADVQRLAASIEAPGAHGSSCETAEYFDQVWVQPRWKRYWDSFESADVTTEQLVATFPFHKFFADAPQPLFSPNTTKQQLLDTAKGCERHINRIFSELADIRPFELLRAQRDKSNYLLVKEARIVAMTSTHAAIRRQEIAQLGFKYDNVIMEEAAQITEIENFIPFVLQKPRVEDGKAPENALQRIVLVGDHLQNSPVIQNNALKTYANLEQSLFQRLVRLGVPHIILDAQGRSRPSLADLYKWRYPSLTNLPFTSTAQEFVSANAGFRHEYQFIDVPDYKNSGESEPTPHFIQNLGEAEYAVALYQYMRLLGYPAGKISILTAYSGQKALIRDVLTHRCKNNRLFGMPGWVGTVDKYQGEQNDYIILSLTRTKSPGYLRDLRRLTVALSRARLGVYILGRREVFESSLELREAFGAFLERSTKLQVVPNELFPTERLVDDATVEAVEMAGVEHLGQYVFEMTNAKVKALKEGTTQLPPPAQDGGGGVEEDGEGEGDEEGGLVLDGDGDVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M3BXX3</accession>
    <name>M3BXX3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_149450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="3641029at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
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        <location>
            <begin position="34"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF12911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="252" mass="28873" checksum="49DCD44F3D987F98" modified="2013-05-01" version="1">MMITNNNKNHPNHPTGTNLDLTYLEHSIRSRNKDVIRHASDSRKPTRFSSSRSSSSSSLFVNNDEDNSIRHYQLDDEVVNFFPRAPGDTTAAAATSLFKRGGHGICGVLTLSSLVLMVVVMIMGGVVGVRKRRLQGRRRRQRCIQRRGQCGRREEEEEFTRGDEEEEEEFAKKCFVYNQNLEKRNWNFDALERGLGVVKEDEEEEEKEEEEEEEEAAGKNGNQNQNGRPLILHHHHHHVSLKAPVIVDLEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_117496</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">Poplar stem canker fungus</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761077.1">
        <property type="nucleotide sequence ID" value="XM_016901342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BY19"/>
    <dbReference type="GeneID" id="27898479"/>
    <dbReference type="HOGENOM" id="CLU_1797676_0_0_1"/>
    <dbReference type="OrthoDB" id="2245455at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF12956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="144" mass="15566" checksum="A6E50D930697F64F" modified="2013-05-01" version="1">MCVPEPEPKGGNMGLQVKSPAMAAALEVATHPSASTSSITTARPAAAAAAAGGGFYYDTFLQSISNDISIYLAKQQQEHQQQQQQHQRQQQTANHISPSSTCRRRPSPMENVVQERCGEQSKKRKTTAKTCCCNFQSGPKCSPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M3BYD6</accession>
    <name>M3BYD6_SPHMS</name>
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        <recommendedName>
            <fullName evidence="3">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_155484</name>
    </gene>
    <organism evidence="1 2">
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="692275.M3BYD6"/>
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    <dbReference type="eggNOG" id="ENOG502RR3X">
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    </dbReference>
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    <dbReference type="OMA" id="IAMSEYT"/>
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    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13238">
        <property type="entry name" value="AAA_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF13071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="21452" checksum="0F8FFCEB58D9FF7B" modified="2013-05-01" version="1">MAAKSQPLFVYINGYPGVGKLSVARELRAILPNTKVFDNHNLIDATSSIYERGMPEYQPLRRQMRRVVLDSIATSESTREITWIFTDQQSSDETGASAAQDYAAAAQARQSSFVSIILTCDLEENVRRLTFASRGGESNTKLTDVDILHHIRDTEDIYHFGGELEIEIDVTHKAPDVVAREIEKFIGSSKAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M3BZV8</accession>
    <name>M3BZV8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_155859</name>
    </gene>
    <organism evidence="3 4">
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        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761717.1">
        <property type="nucleotide sequence ID" value="XM_016907646.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="27904783"/>
    <dbReference type="HOGENOM" id="CLU_1066234_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF13596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="261" mass="28590" checksum="5013CF11AA154F83" modified="2013-05-01" version="1">MSSRHRTRYRRGGCFGTRTRLAALSSSASFYIHIYIYLTEAKPWPSSADMVHIKALMVSTVLSGMTSAGLAPSTYANATTSSASVEHAALNPLDRQLIPFIPKFFSRPGRTSSSSVENIHAASPDYRSDTSAVYPYTTSISISESRGHKTRSRRTNQHTRRNRPDQIAHHRPAPTSHEVSISWSTVRNGATPSPSDFPTQKHNSISSPDVRSSPPHTTISYYPIRTTLPPGQTPSLEAAAAQRSGNSCTTLCTSPRCERTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M3C121</accession>
    <name>M3C121_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_147856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF13986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762107.1">
        <property type="nucleotide sequence ID" value="XM_016904555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C121"/>
    <dbReference type="STRING" id="692275.M3C121"/>
    <dbReference type="GeneID" id="27901692"/>
    <dbReference type="eggNOG" id="ENOG502T9B5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_282714_0_0_1"/>
    <dbReference type="OMA" id="TEHTWHA"/>
    <dbReference type="OrthoDB" id="3638668at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="804"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="821"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF13986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1104" mass="119858" checksum="B2DBC640D815A720" modified="2013-05-01" version="1">MCQYRYYYYAGCRHQRTVLSKCCAHAKSTAIALAAQQRDPGAPVKAEEFENDGEESAHDEAASASSRPALSTRDSGITTLSSCPDTPPDSDIAHHTSASIPELNSEVTSLHRPHSTCSRRRKVVAIDDMAADVGTSFTKPSWGQPNQRMTGAPNTDLSWAVVDRKENIAHKTHAPSQTQTQTRLAHQQNDQSYHFTEHTWHAASTQPSDHGFSQDRKVLDLGREFADMQAQLKVAQEELARLHAGEAQRQSAIDTAASVDESGPSGPYCHSGASPAALLLREHEKATLQQSCQSDFAMHDKPQPLHSGLDFPGLLDLHCTQSKTPEGPATTPRKPSYANMATQGMLNAIGQNFPSSTGSSRGPNTSNDSTYAHTGCSCTASHTSTDATTDAEVGNDSAVVSPRSPDDCSPGLDPVSTLKSHRATKFSPRFAQPTVAFTRRADETIRKDSFLGVGKTGSMKKPSTMCSPHQKQQKRKSLPGDWFGQPSEPACPSAQTSSENHSFEHVNGFHGCPEPTLRKKTSTYMSPTKAATRRTIATIGHDSATPSPPRLPRNLAKLALNTDITSCSDISKTSSPTSPETAIETENVSLRGIQIQPRMSEKLDVSRPRRLPVNGALAGPQRLRPNTFASGLLAAQAKAAGLPMPANTTAQRRGSHGHLLIPIKAKLDRIGILKENPRPANVRRGSELLSPISQSSESELFSPLTRSICAAQAAALPETQHMSQCTEAPQKPKKAVPPHVRAAIRDATAAAEAAGATHAPSLRATAQEFRPMFDLAPAPQLGLAPRQAHMADQAIAQPLLEPKQHGLDKSPFQISPGISFPQAQLQDPNSLVHRSQGSESGFNRLPRTSMLRSFTTATASLPFVTDEDAKKFYDEEEWSSLTSYDRKRILERREALRYQEQARSHPFSGFPETLVAQPIAVQGGHVLLPSVDPITKVVSWTLDNKDPMSLGSLLPTDPQFAVDHIQQTPSFRVPRTPDLVPRSWTVGSEQARQVFGWKGGDGREIKFVGHGPDAEREPHHGVRFNYQRRMTSMGRGPRMIGEDMEDGSPEVPLAPRGRRQWAQLAGSPQQPCDRMDIVDAVEQIPIPFGPALHGFCDGCAVNSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M3C1I6</accession>
    <name>M3C1I6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxysterol-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_147976</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762292.1">
        <property type="nucleotide sequence ID" value="XM_016904629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C1I6"/>
    <dbReference type="STRING" id="692275.M3C1I6"/>
    <dbReference type="GeneID" id="27901766"/>
    <dbReference type="eggNOG" id="KOG2210">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012334_0_2_1"/>
    <dbReference type="OMA" id="WEPLFFK"/>
    <dbReference type="OrthoDB" id="14833at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008142">
        <property type="term" value="F:oxysterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF92">
        <property type="entry name" value="OXYSTEROL BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="309"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF14171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="393" mass="43591" checksum="E5895BD99C1A6873" modified="2013-05-01" version="1">MADTSEQQSGLKQFLASIATIKGDLSTITAPPFVLADKSTTEFPRYWIEQPELFNAPAHEQDAAKRILAVLKWFLASLKSQQYAGRQPSQGVKKPLNAFLGEVFIGDVGATEDDQTHLIAEQVSHHPPVTACYLWNDKHGVRAEGYTRQDIRFTGTVNITQIGHAILHLDAFDEDYLIPLPNVKVTGILTGSPYPELQGSYSIVCSNGYVAEVDFSGRRMFGLAGDKNHVTAAVYPPQDKKHKEPIYVAQGNWSEQFEIKDNAGTVIDTYSVASATASQFRTLPIERQDPWESRKAWQGVIAAIKAGNMQETADSKNKLESAQRELRKRTETAEESWRALFFTKETGHPIAEKLLAEAGKNLEVQSTVGVWRFNPSAASSLQRPWRGDLTPFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M3C2X5</accession>
    <name>M3C2X5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_148286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762747.1">
        <property type="nucleotide sequence ID" value="XM_016904825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C2X5"/>
    <dbReference type="STRING" id="692275.M3C2X5"/>
    <dbReference type="GeneID" id="27901962"/>
    <dbReference type="eggNOG" id="ENOG502R99F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_420983_0_0_1"/>
    <dbReference type="OMA" id="DIAVCES"/>
    <dbReference type="OrthoDB" id="3946381at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="11"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF14626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="721" mass="78083" checksum="D5EB335EFFB6B0B1" modified="2013-05-01" version="1">MVSTKDFAVATASQLLDGTPSSSRPQYLDIRTQQYESQILGSHQSKGTPQLKRSSAVRKSVRFVPSAIGGSEKDNSSPEDPVDTTDTFTQSQHASQVSPEQQLSQGSVTEPSSPELLQPVVYSPIAAGKTDDRVAAALASGIIRSDTVRHKVGVLEYSTRVLPQVPETKSILTTELHIDTDSHKRNLSNTSSASSSDRPRRKRSSSGAKEIYFTPTDVHSSRTCLSSPLNSPTLPRDYAEDDDDDDDDDLPTPRATTSASLTRPPSAIYVGPVAAEPPAESSADVHADERRQIPDQTKPTIRITPEQLDQLVIALARSKLVRRHLQQDWFDPDEVPDDDGSKASSSSTVSAPTLTSASTLYSQQNEHGPPVNKESRSGSAPENTSRVKLATPATRHSESVVICDPKIYGTPAKCVSISHNTTTVVGTRTFLMAPGGSEVECSLRLQPASTTQHTNVRVFLQCVNQIVDRKSGNRSSLLSAEIDVTAHIAHAAIAELAEGTCLAISDIAVCESPTSPSRASILRSTPNSLDVNRNSSSSISSSSNNIDYWIAIADDLQHRDHIHTMIDTAVNVFSHLDATTASLSTLTFLRHLTHLADQYHDILILQPTSWHADGVTPHTIKIPYCSRRLYEDWYTDPRGSQAGEKVGESAAARGFQRGIVSAVAKRAGEVEGFRIEGFWEKGGRVRQALRVVPMSGGGGGEDKERLWCCFVLGEEDDFSGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M3C3M3</accession>
    <name>M3C3M3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_155467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762977.1">
        <property type="nucleotide sequence ID" value="XM_016907623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C3M3"/>
    <dbReference type="GeneID" id="27904760"/>
    <dbReference type="HOGENOM" id="CLU_1332673_0_0_1"/>
    <dbReference type="OrthoDB" id="3637692at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF14856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="206" mass="22641" checksum="66A31CD30B555903" modified="2013-05-01" version="1">MDHNSSSGSSKMKEYLCPHCGGNFRSGPGLCSHEKARLAKDGVCGDSRRGDWTSSQPESTECPYCEFACNSRAGLASHERARRNNGGYCKESRLRSSGSQIWLSAPRDPTRHDTPIAQMPTTVETPRTTKLRSNPPSTLEKNTSPLDITDVPPGQEGMWKVNPATGKRILSSISGLPMLDPKSRDYVANEARKYTPWMLNSNGKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M3C3Z0</accession>
    <name>M3C3Z0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_36834</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF14956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763077.1">
        <property type="nucleotide sequence ID" value="XM_016908650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C3Z0"/>
    <dbReference type="STRING" id="692275.M3C3Z0"/>
    <dbReference type="GeneID" id="27905787"/>
    <dbReference type="eggNOG" id="ENOG502SUY1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136928_0_0_1"/>
    <dbReference type="OMA" id="IGMNTAN"/>
    <dbReference type="OrthoDB" id="3648350at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF14956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="129" mass="12890" checksum="CEDEE7F87594FB18" modified="2013-05-01" version="1">MYNVTILSLGNTTNSTGGEGHVAAGGKLSPFGDIGVGCGVNWENEVGYGGGIDAGSSDFGLGGGWKITPTTLELGTGIGISADNSSANVNFKGSTNGTFELRFESTAQFACGTPAKADGKWSVICSTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M3C4Q1</accession>
    <name>M3C4Q1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_105565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763402.1">
        <property type="nucleotide sequence ID" value="XM_016900583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C4Q1"/>
    <dbReference type="GeneID" id="27897720"/>
    <dbReference type="HOGENOM" id="CLU_1603775_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF15281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="166" mass="18777" checksum="4AF7C78C8DE87D7D" modified="2013-05-01" version="1">MTSRNGISSIFILQKKPPLPPPYQILKISSITTRQQQQQQQQQQQLYPKFPSTDSTLSPTPQTQYINHPPLNPIKSSSRNIRGQKTYPSRDPCTASFTSTPSSSTSPIYCLTGSEYYWTSNRRSAVVAVVVGGGVVVDYDNKDNENGKSENIWWHWREERWNVAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M3C599</accession>
    <name>M3C599_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">small monomeric GTPase</fullName>
            <ecNumber evidence="2">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_131118</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="2"/>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763547.1">
        <property type="nucleotide sequence ID" value="XM_016902396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C599"/>
    <dbReference type="STRING" id="692275.M3C599"/>
    <dbReference type="GeneID" id="27899533"/>
    <dbReference type="eggNOG" id="ENOG502R0Y0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_738032_0_0_1"/>
    <dbReference type="OrthoDB" id="265044at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051065">
        <property type="entry name" value="Ras-related_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45704">
        <property type="entry name" value="RAS-LIKE FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="198"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="264"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="209"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="294"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF15426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="375" mass="42538" checksum="D0269F40AA99B4F3" modified="2013-05-01" version="1">MAHLSDKSSNVRRYLYSKQHIPTVRIAVLGCGNVGKRSILRRFCYGSLSERSPTSKTELEWHKHAAVQGRDVHVQFDMMSDEPSRMSELDLLDFWRYNEAYMVVYDVTDEQSFDVAGQLCEVRSQIPREHPWRVPVFLVASKVDRWRGGWAVPLARGEELAKRVDATFLPVSALSGEGTGDEVIVDMVGSVLWSRYQNEMDSPPRPGTHADTASTSDAATEWPLPSSQPPPRPPTIWQRTGPGILRLLHRSGKLLEWLKPKQNVHHWTPPTKYPERKDSSVVLEPPPPLPTEQARSRSLTDLRRNRSKSVVFAINKTDTPEPPLPPDTLGHPAKPYRPNKRRSRTMSLEMSLSGEYFRQARDQTPVQNPPRACAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M3C5T0</accession>
    <name>M3C5T0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stress-response A/B barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_80552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763752.1">
        <property type="nucleotide sequence ID" value="XM_016910251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C5T0"/>
    <dbReference type="STRING" id="692275.M3C5T0"/>
    <dbReference type="GeneID" id="27907388"/>
    <dbReference type="eggNOG" id="ENOG502SEPI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080664_6_1_1"/>
    <dbReference type="OMA" id="QIATWKE"/>
    <dbReference type="OrthoDB" id="42919at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013097">
        <property type="entry name" value="Dabb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37832">
        <property type="entry name" value="BLL2683 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37832:SF1">
        <property type="entry name" value="STRESS-RESPONSE A_B BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07876">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00886">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51502">
        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stress-response A/B barrel" evidence="1">
        <location>
            <begin position="3"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF15631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="100" mass="11002" checksum="E69C516811692DE7" modified="2013-05-01" version="1">MGVYHIVLFKLKPGVTKAQIDALEAAGRQMVGQIPGLIKFDFGPPLASTAHRALGYDLGLVATLERPEDVAVYAQHPAHLHVHHFREQVSDDTLAYDLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M3C9G5</accession>
    <name>M3C9G5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_152107</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756576.1">
        <property type="nucleotide sequence ID" value="XM_016907246.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.M3C9G5"/>
    <dbReference type="GeneID" id="27904383"/>
    <dbReference type="eggNOG" id="KOG0198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001872_1_1_1"/>
    <dbReference type="OMA" id="VKQIKLV"/>
    <dbReference type="OrthoDB" id="8693905at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06627">
        <property type="entry name" value="STKc_Cdc7_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000246">
        <property type="entry name" value="Putative Serine-threonine kinase SepH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053235">
        <property type="entry name" value="Ser_Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361">
        <property type="entry name" value="MITOGEN-ACTIVATED KINASE KINASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361:SF433">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="118"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="396"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="554"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="727"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1333"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1400"/>
            <end position="1428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1441"/>
            <end position="1533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="415"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="574"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="741"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="762"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1354"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1374"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1419"/>
            <end position="1428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1441"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1466"/>
            <end position="1478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1494"/>
            <end position="1506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1509"/>
            <end position="1520"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF08455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1533" mass="168396" checksum="D5CD8EF28EEB564B" modified="2013-05-01" version="1">MVSGTMPAPLISPPPPHATPAQGSSRPSTSHRSSTNVSQARPHATPKQSSVGGNGSGVLRSAKVRGSSDKENGGEKSAPARSTRRPSTASALAPREKLPSKDGTAQRNAKQVEGLKDYQLGQCLGRGAFGSVYAALNWSTGETVAIKQVRLSDMPKTELNVIMQEIDLLKNLHHPNIVKYHGFVKSTDSLYIILEYCEQGSLHSICKNFGKFPENLVALYISQVLQGLLFLHEQGVIHRDIKGANILTTKEGLIKLADFGVATKQSGLAEGSVVGTPYWMAPEVIELSGATTASDIWSLGCTVIELLDGKPPYSKFAPMPALFRIVNDDHPPLPDGASPLVRDFLMQCFQKDPNLRVSAKKLLRHPWIVSAKKGNKAKPTEYTEAVKSVQEWNEALKASPPPSHSNGSSRRPSSKIASRPTSRSSAKPGVAGTKAKPDQASKPAFRLGQRRSQGPEAFQSPLENTRRDNWDDDFASLVGGIAGLQLPPHLKPQHAGMFSSEKLKQYAHVDAIPQTDGKVEGWDAEFQGELTIRSSMELTDGNALETVRPYYPSRTTSEEIKYQPPQGIAPKRSGTHDRHERKSSKDSQPKTQILKPASKHSAIPKLRSTPPKQAIKPAQPTSTHQDRFREEEEEDYSDLVPHDEDAFLKKLAGYSPGRNYNPRDLNIQTKLNGSLRRRRTHTPTQLVHDAAAMRRNRSSLEIQKYAEDDDDEDFDTDLVFDQQHISLQSAKEHTQTRRSSPKSSGSSDASGTLRLTNSISWGDDDDDEEEEDPFKALEEELDEVDLESNVARDKHARLCAVVEGLVSDLKAGQSEDVLAEIVDQLVMVLAESPDVKNVIVSSHGMLPILEILSETTRSYIVLRLLRIVNVILSDNIEVQENLCFVGGIPIISSFASKKYATEIRLEAANFVRMMYQNTGLTLQMFISCGGLHVLVEFLEEDYDSEAGRELVLVGVNGIWSVFELQGPTPKNDFCRIFSRSAVLYPLSLVLNRVLDEDDRELADIVEGRVVNIFLLFSQAENHVKELIADRMVLKRVLKDLRRLRPANQVVMLKFIKNLSMLSTTLDALQNSNAIEVLTDLLGSSMPSHSRTTASAQHFRDISNQILATMYNLCRLSTGRQEDAALSGIVPLLQKIVKTERPLKEFALPIICDMAHSGKVGRKILWQNKGLQFYVSLLADQYWAVTALDAVFIWLQEETAKVEEHLLDQSFRFDDALVQCFNESKADAFENLLEPLQKVLRLSPAIAASLANRSLFERAAVKMHSKKALVRLNLLRVIRSICDACEGQGMIEHGSMGDGGSLLRRYNLLEPVKELARHDPAILVREMANDLVKSSEVADGRPVPTPSRPGGGYAMSRRSSSSVSIMTPPIPIVSQSPSGNFSNPLSAGPIVGSRGSYFELMPPTLDRRPSAMSVNRPMSRDSSTGSSSSLASLNALAVLPVGSSSSRSSSRVPPPHHERSNIGSYQRPPSRSSRMSLMPDHGRLLSPGHAVSGDLQITPTHAPTGTRSAHAAHQRPVRRRGTGTGSVDLGTRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M3C9Z5</accession>
    <name>M3C9Z5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Class II aldolase/adducin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_166379</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="eggNOG" id="ENOG502SKYK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019323">
        <property type="term" value="P:pentose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050197">
        <property type="entry name" value="Aldolase_class_II_sugar_metab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22789:SF0">
        <property type="entry name" value="3-OXO-TETRONATE 4-PHOSPHATE DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22789">
        <property type="entry name" value="FUCULOSE PHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="4">
        <location>
            <begin position="30"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF08680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="330" mass="36098" checksum="58498E8AD3FF14B8" modified="2013-05-01" version="1">MSSSPETSNHATTREALLKASTPPSKHLFSTLITANHILHHHNVVDAYGHISVRNPQNPNTFFMSKSLAPALISSRADIEEYHVSDASPVNPNAPKGYQERFIHSEIYKRYSDVHSVVHAHNEAVLPFSIGSVPLKPVYHMAGVIGTHVPVFEISNHYKPSDHLHSFLVNNEHLGAGLAAGFHPTTSQFAKVGGLIKNYITAAASSPPAEPAFPPCPVVLMRGHGFTNVGATIEDAVFRAIFTCKNAQIQATSLLMQSTFNLGAIARQFGAKQESTEQAPQEGIKFLSEREAGDSWTQMQGTVERPWGLWCEEVRSVGLYRNEVRDGSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M3CA07</accession>
    <name>M3CA07_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_128342</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016902210.1"/>
    </dbReference>
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    <dbReference type="STRING" id="692275.M3CA07"/>
    <dbReference type="GeneID" id="27899347"/>
    <dbReference type="eggNOG" id="KOG0165">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_318103_0_0_1"/>
    <dbReference type="OMA" id="YIPPDDT"/>
    <dbReference type="OrthoDB" id="76388at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051295">
        <property type="term" value="P:establishment of meiotic spindle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007051">
        <property type="term" value="P:spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051185">
        <property type="entry name" value="ASPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22706">
        <property type="entry name" value="ASSEMBLY FACTOR FOR SPINDLE MICROTUBULES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22706:SF1">
        <property type="entry name" value="ASSEMBLY FACTOR FOR SPINDLE MICROTUBULES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="294"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="399"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="771"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="302"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="418"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="436"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="771"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="811"/>
            <end position="826"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF08695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="915" mass="101243" checksum="DF34FE627EDF4AFB" modified="2013-05-01" version="1">MSRILQTPCPAPTSALDPSHRRISSFELFGDDTTTNIDYTRAIDQPLTGIKPRRRSMLMGPARKKTTAAPVTIFEDVSEEQEMYVEGGQDLRVSERAERLGNGSTLLGKPPAKRMPAVVGSGIGRSTGMGGYGMGYSRSERTGTGSGNRGTIGEVRNITDLHSGGPLGAPYRAVTSNATNLHMTNRHSVALEAAPSTKVGTNNMAGIGSTVRKLPRRQTIFIPEDTTMMSIHPGPRDNTSRIDDSFHNSNLAVSQPQNLRDQCNNGAPHQARSTLGAPAMKNIQRRQSIFVPMPEQSTAHRVQPETTHHSNRIDDSFQLPSLPSPQPKQTQNDTVFAQKPLRKPRQSLLAPPKRLPLRESTSSENMPGWDVAGANTGKENIPPDGHVLVEKGLKCLEISDQAQPRRRSIQPRVRSSLYGPTQASQHRQSVVPRPQVSASSTVSNRVRPTVSFQEPLQQSGNSKPAPVSRDDEVKRVREFIANKRVEQQTARLRQYPVLEGALSEPALYEGKWPSYREDALSEVINRIFEATSSVSAMHASTAEFSLMDQLISLYNRPQTTVLHDRIRASLEYGALACPQSSVSEHQPSKDRGLQQQLLDLWFESYDSKLLMAAAQVVTGRQIASTSVDLQSEGHLGRQFFKDFFINAIDVDSLPSSTDVEIDLQRWRKTMLRSVMLVWLLDQAAEARLTNGGCLLKSSSLRKSSAAILQTLGVLMLPACGDIMRALKHLTYEVSYHQNPLDEIVYHVENIAVDFRDGVFLTRLVEVLLYNNNNNNKNNNKPTNPTRPDPNILDDLTLACSTPLPEDDDNNNNKSTLTLHQQPQRPLTQHLKLPANTPVHRTFNIQLALDAFFSHLAIHIPLPRKDEEEDNKIVNNIPAAIATATVEDILHGHREKTLDFLENLVRGFGGLDGLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M3CAN2</accession>
    <name>M3CAN2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_158990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757011.1">
        <property type="nucleotide sequence ID" value="XM_016907816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CAN2"/>
    <dbReference type="STRING" id="692275.M3CAN2"/>
    <dbReference type="GeneID" id="27904953"/>
    <dbReference type="eggNOG" id="ENOG502R2EP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_446194_0_0_1"/>
    <dbReference type="OMA" id="AFTRMLM"/>
    <dbReference type="OrthoDB" id="428854at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="340"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="376"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="459"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF08890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="564" mass="58927" checksum="8E019869EF0B8880" modified="2013-05-01" version="1">MSAGNPFRRSRVPVEPDAASANIFGAVRAAPDQAASSTPPPLLPPMKTGGVVNQPHTPEEAHSPRNGDRRPPANDDDARGNSRDTHTSENDRREDEFTTTAASSAVDQAASDQRGSLRRTDAAAGGMRAPYNPFARTLASREAGFGLSEDSRETAEGGGRENEQRAKPALDVDAFKNILMTGAPIPTGLSTHLGTPRPHHITTEAPAAYDAAYGAHPESPRDIHHDYDSTSEDDEKSELMGIGRSEDLAPPAPPKPKTKGPQTVSFADFDQSIPPGFVSSRSRSPHINAQHLTGILRSASPRPGSDLNKPLPAPPTEPTEKSSPALADASGPLPRADVQSPTTSSSAKSIPPPPPTRKSGAGHGRARSSSNLSNMTTDSTSSTLADSGPSTSSNKLAPPPPPTRKSGNHSTAQPQAKGPSSPHPEARLTPPPPPPLRRLSSRSARGTSNLGRQASEDGSSMAETTPAPTTSAPPPPPPRRPGSKRTSLDGAPSSFPRRLSGEYYRGTSFDSERPPSISSLQKVAEGGEGSEQASMSPGAERDILAEMSAFQAEIDALSQAAKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M3CB28</accession>
    <name>M3CB28_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_120926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF09040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757161.1">
        <property type="nucleotide sequence ID" value="XM_016901646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CB28"/>
    <dbReference type="GeneID" id="27898783"/>
    <dbReference type="eggNOG" id="ENOG502TBGQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_193137_0_2_1"/>
    <dbReference type="OMA" id="ANSGQCG"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="60" mass="5661" checksum="9341EA5E0EF0FA17" modified="2013-05-01" version="1">MSGQMTKGDASRIQSGNAKSGNDSGFAARAQSAADRSANTAASKGSNGGNGGNSGGAKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M3CC43</accession>
    <name>M3CC43_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_70948</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF09967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758088.1">
        <property type="nucleotide sequence ID" value="XM_016909922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CC43"/>
    <dbReference type="GeneID" id="27907059"/>
    <dbReference type="eggNOG" id="ENOG502TJP1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1107696_0_0_1"/>
    <dbReference type="OMA" id="YRICIVT"/>
    <dbReference type="OrthoDB" id="3637222at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF8">
        <property type="entry name" value="ESTRADIOL 17-BETA-DEHYDROGENASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF09967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="251" mass="27426" checksum="85E072FE9073C331" modified="2013-05-01" version="1">MSIIERTNPLNLQYKICVVTNASSPLGVVICKTLLKANALVLGIDTRPRDHSLNAGLGTHFQFEQVDIKELETPKKIIEASQEKFESLGGKFDALMNLVEKEDDDDDVAGIANLTKAIGNVMRETGQGSIITVAPGSVNEVESQSKRQMIDFAKSLMQQFQDNSNSIRTNIIIPEAPSETQQSTLAYQEAQTHMTALIKTEEKSAIQSQQTTTTTPAEFYKIANLVLFLAGGMSENLSGKIFGLDGSCREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M3CCB8</accession>
    <name>M3CCB8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_151086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758143.1">
        <property type="nucleotide sequence ID" value="XM_016906588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CCB8"/>
    <dbReference type="STRING" id="692275.M3CCB8"/>
    <dbReference type="GeneID" id="27903725"/>
    <dbReference type="eggNOG" id="ENOG502SQDU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057752_6_3_1"/>
    <dbReference type="OMA" id="AMTHRVE"/>
    <dbReference type="OrthoDB" id="3646030at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF5">
        <property type="entry name" value="BTB_POZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="18"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF10022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="139" mass="15775" checksum="9C13730A0B42C9B7" modified="2013-05-01" version="1" fragment="single">METFAETAPAYLRDAQFSDFTIVCGAKEYKVHRVIISSHSKYLARCCSGDFQEAMTHRVELQEDDPAAIARMIEYFYKFDYEDREDTANATENTIQINAIVLVAAEKYDVQGLKLLAREKYKTACSSKRHDSMALAKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M3CD05</accession>
    <name>M3CD05_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_50688</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758418.1">
        <property type="nucleotide sequence ID" value="XM_016909173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CD05"/>
    <dbReference type="STRING" id="692275.M3CD05"/>
    <dbReference type="GeneID" id="27906310"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075838_3_0_1"/>
    <dbReference type="OMA" id="AMCYQWK"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF10297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="127" mass="14547" checksum="7CC6763D48927B33" modified="2013-05-01" version="1" fragment="single">LPRLINCLCCQRAFTTFPGMIIHLESGTCQSGEDVDSINLLAAHCFQWKKYMHKGCRESFIARDKTYIEWTGAKPFKCPTCDHQFALLSSLLQHVWSSACAQGKRGGAIGKLIRWLSKRTYRYRTGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M3CE36</accession>
    <name>M3CE36_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Probable enoyl-CoA hydratase, mitochondrial</fullName>
            <ecNumber evidence="2">4.2.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_126863</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="2"/>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759422.1">
        <property type="nucleotide sequence ID" value="XM_016902108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CE36"/>
    <dbReference type="STRING" id="692275.M3CE36"/>
    <dbReference type="GeneID" id="27899245"/>
    <dbReference type="eggNOG" id="KOG1680">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_6_1"/>
    <dbReference type="OMA" id="FCDARED"/>
    <dbReference type="OrthoDB" id="2018133at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000019">
        <property type="entry name" value="Enoyl-CoA hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000001">
        <property type="entry name" value="Probable enoyl-CoA hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF54">
        <property type="entry name" value="ENOYL-COA HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0843">Virulence</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF11301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="290" mass="31464" checksum="6E748605CE812E5D" modified="2013-05-01" version="1">MLASKLRPSATQFGRFMQPLRIRTYSSATETTYEHIKVSTPRAGVGLVELHRPKALNALFTPLILELNSALKSFDHDSTIGAIVLTGSHKAFAAGADIKEMSTKTFSDAYGDDFIESWSELPATIKKPVISAVNGHALGGGCELAMMADILYCSEKANFGQPEIKLGVIPGAGGSQRLTRAIGKSRAMELILTGKSFSGREAYEWGLAARVFATPEECVEGALATAEMIAGYSKIAVKACKEVVNKSQDLGIREGVEYERRVFHGLFGSQDQKIGMKAFAEKKKAEWTHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M3CFB0</accession>
    <name>M3CFB0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_43969</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760619.1">
        <property type="nucleotide sequence ID" value="XM_016908909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CFB0"/>
    <dbReference type="GeneID" id="27906046"/>
    <dbReference type="HOGENOM" id="CLU_2672688_0_0_1"/>
    <dbReference type="OrthoDB" id="361797at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF12498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="75" mass="8861" checksum="DB5972E07892A813" modified="2013-05-01" version="1">MAKLTECTVSQALSPFLFVRRAATKQHWTDRQLHVHLQPYDMVVFLSNQLNHSTMAVEGDPYDEERWSICFHQRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M3CJ00</accession>
    <name>M3CJ00_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Dak phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_148967</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-glyceraldehyde + ATP = D-glyceraldehyde 3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13941"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.28"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dihydroxyacetone + ATP = dihydroxyacetone phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15773"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.29"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761899.1">
        <property type="nucleotide sequence ID" value="XM_016905260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CJ00"/>
    <dbReference type="STRING" id="692275.M3CJ00"/>
    <dbReference type="GeneID" id="27902397"/>
    <dbReference type="eggNOG" id="KOG2426">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_515926_0_0_1"/>
    <dbReference type="OMA" id="YCIYLTA"/>
    <dbReference type="OrthoDB" id="2139957at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050354">
        <property type="term" value="F:triokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.340:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050861">
        <property type="entry name" value="Dihydroxyacetone_Kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629">
        <property type="entry name" value="TRIOKINASE/FMN CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629:SF4">
        <property type="entry name" value="TRIOKINASE_FMN CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="DhaL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaL" evidence="8">
        <location>
            <begin position="327"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="305"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF13778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="516" mass="55611" checksum="29C3CE147B0EC43C" modified="2013-05-01" version="1">MAIVVEQTLPFPSSTLDLENATRWTTLLPLIRPSLKTVRTPEGQDLVVNTARAAGNHVDIIAIGTGGNLSSKVLDSKHVTAIIITQHMGASAIRAADLPRVLESAGIQCPRGVVVVRAGKQRRLDVHQSDVLEFQTNGELEQDHVLQLLRTATETTRSDVRNISDMLQAFAAEAVTTNSKFHAVKTDGGPAVLHHDGVQVFEKAKNAVERDLKHLFQQLSPQSEDIVYSVHYSDVNGLSRLENYIIANDIASYLDCQEVRYTLSHSTILNHTDHARGFSMSVCPLPSHFIAAKPKPKAHQPIGATSGTTKTTKSLSPTTPKIVFEDASIRNRIENGCNAVINEELVITEYDTIVGDGDCGYTLRDGAKKVLSFIADKDLGQLPATLADLVAELEVNMGGTSGALYCIFLTALVSSLASEDSVAKALKQALEELCQYTNARVGDRTMMDALIPFVDTLVMEGDVELATAKAKQGVEGTKMLEAKLGRSSYLDESATRGVPDPGAYGLLVLLQGMASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M3CKK7</accession>
    <name>M3CKK7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C2 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_62551</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762429.1">
        <property type="nucleotide sequence ID" value="XM_016909607.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.M3CKK7"/>
    <dbReference type="GeneID" id="27906744"/>
    <dbReference type="eggNOG" id="ENOG502QQWJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003023_0_0_1"/>
    <dbReference type="OMA" id="VLKSPKW"/>
    <dbReference type="OrthoDB" id="2015333at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04043">
        <property type="entry name" value="C2_Munc13_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052811">
        <property type="entry name" value="Glucose_resp_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010439">
        <property type="entry name" value="MUN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014770">
        <property type="entry name" value="Munc13_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014772">
        <property type="entry name" value="Munc13_dom-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47263">
        <property type="entry name" value="ADENYLATE CYCLASE ACTIVATION PROTEIN GIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47263:SF1">
        <property type="entry name" value="C2 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G02350)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06292">
        <property type="entry name" value="MUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51258">
        <property type="entry name" value="MHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51259">
        <property type="entry name" value="MHD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MHD1" evidence="3">
        <location>
            <begin position="706"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="920"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="domain" description="MHD2" evidence="4">
        <location>
            <begin position="1155"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="765"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1284"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1382"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1285"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1329"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1383"/>
            <end position="1398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF14308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1420" mass="161769" checksum="74041F6C6C4878E4" modified="2013-05-01" version="1">MERRSIHSSTNSRRTNSHAATRETLRRNMSGSHAKRVAHVSEHDVYLYALRAAYLAYLLQPRQKRVQHVANTSKPIQRSSTSINDMVKDFSLIRDSKSTRFPHGFMTALDKRLTGVLTGTERMPEFNNNDIKRTFGVFLNEFKNPTFRKSMEKDRKVEDLLLIFFSKATGTLQLGKAPDDDGWKLMVDRHVALFVRLISSTLNNNEWARDRPELTSRLKSLETKLLQHDQDLADEKQRNGGHGGSSVEVEVPRSYEVKDMPLVIRVCRIFSKPTAQAQNDINAHKEQWTEKEALRDLKEYQTHMSLNTRATLSKDDFDLDDAYEAWRKGEFSDLSQLMLALLQSDPNLAKSSSGSLAQYKAPPMAHGDSMYSELGKSLSKQSGEFDSGYPLDQPVDMSSLNLGDSSPHDSGTGSTDTTHASFTFIPPDTRAYYRQTLKVALTADLEDEDLQTMGEGTKLLSPQTQDLLNEIALRWRVPPFTRLVLFLDVMREKYQNQEISLDTLDMAFQFAKAPPPEVKKGKGHSVHADFHDRSRWTITDFATIQTVLNGLQDALLREFYEMFQHAYENKLPPIGSILLILDQHIWSDPSFHRNAEDMATFASMMSEQLRAKARDQYHDLLAKNVPDDSANWEFYNVIQLGQSVTAMCNKIQKRFRKTPDVLGVKPLAILVEEILPSFSSDAKELVARIMEVTKSKNEEVPVEDGFELYGEMVSIRAVYSQALPGREFTFDIEHHLQEFVWRWIQLTDSKLHGWVESAVEHDDFQIRQEPAAKERGEPPTDDERHSQSVVDIYRMFNESIERILRLNWDNDLQYAKFMTAISKSIGKGVARYCELLEAKFAKEMDRQTPEQEARAQQTQREKWMSAARDAWVTGSLSQKIEPFNFWPESFVKINNIEFATLQLDKVEQEMNVDACVQAIQKHEPPPPPHVRKRGENKFMFTIKIIEAEDLKAGDMNGLSDPYVVLGDEYQKRLAKTRTVYQSLSPRWDETIDILTTGPLNVIATVWDWDALGDHDCLGRTSLKLDPNHFNDYLPREYWLDLDTQGRLLVRVTMEGERDDIQFYFGKAFRTLKRTERDMTRKITDKLLAYIQQCLSRRTLRGLTNTSTSAAIAGVSMNTMRGYFAKVSNQVQGRSAPVAGLSAQAPTGSALVDQANNALKPLLQYFDDNFAIMKQTLTESSMTMVMTRLWKEVLVQIEGLLVPPLSDKVSVQRPLTQTEVDVVYKWLQTLFEFFNAMDPESGMADGVPTDVLKSPKYHDLQNLNFFYFESTDNLIRTSEAMASATAARQQEQANRPNRMSAPAGFLSPAFGGTRRSKSIMQSRNLGTMRKAKEEKRKEAQADPNDDMILRILRMRPEAEKYLKDRSRQKERLAAAAAAAAIVRQSLQSSKAGHSYSQSLGGPQRGGMQRGGPARQWGTIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M3CP19</accession>
    <name>M3CP19_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_80332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763644.1">
        <property type="nucleotide sequence ID" value="XM_016910240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CP19"/>
    <dbReference type="GeneID" id="27907377"/>
    <dbReference type="HOGENOM" id="CLU_991017_0_0_1"/>
    <dbReference type="OrthoDB" id="10646943at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF15523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="281" mass="31909" checksum="14A1A2D6F057BA62" modified="2013-05-01" version="1">MPSYLEAQVTSGNYFSRKPVRANSTIRQVHAPDESSSDPSLHEPISHDVKAAPNGSHTEHVYHNARDPKLFQSNDCFSRQSSRLPHPFQLLPTTVSPPKSFAFELEPLMERTPGVLYRVGGEVAYQDVCVVYRARPHSYRELTADRLGAAYADATISAEPLTSRPVPEQITQDWRDREQYARGFSYNRQEVHDQEVEQTQAVLDVSFYLDAVEEQEVNDHTMESSEQSMHIHATGDLIMSDALPQDAGSVRQSEGHHELVQEQFDYHYHGSNQYAHTSRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2022-12-14" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>M3CPJ9</accession>
    <name>M3CPJ9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_80637</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_2428454_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF15668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="91" mass="10268" checksum="585549CB2501C082" modified="2013-05-01" version="1">MNKQHGMAAFKAQVSITNDVMQITENGPPPSVGLHSQSKRTWLRFFHADHRIFTFPSQLLSYQALENPHQHSGPDVTSLGLALFWRAGRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M3CQI4</accession>
    <name>M3CQI4_SPHMS</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_106122</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764059.1">
        <property type="nucleotide sequence ID" value="XM_016900612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CQI4"/>
    <dbReference type="GeneID" id="27897749"/>
    <dbReference type="HOGENOM" id="CLU_839822_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF15938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="331" mass="37963" checksum="F87A7AACB167F8E6" modified="2013-05-01" version="1">MHLFLDFNSSRDQFPSAISEPPTPSLDGNVLQATEIPSHQIQQQRILRTGIIEPPPIYEDRAQPIQQQSIPPGTSEVREEQEEASRETLITAQLVAQYIPRPPPPQPSSSYPYSHFRFPSNSTLHTSSISIPTTATFSDFLRTILNPLLLLLQTEREAEAESQILQTTAGTITTATTTTTSTYNNNNNNEELQCEIYFLYPKFNFNLHLGGKWKLKWNKWMRRNSSGSTMRNIQVNEENWPMVVAALRDNENKSNERRRGMGGRGFLEGVGEGEYNGQDEEEKGKRQGSLLRVLYWGRSEEGQVETDARLRREEEAVRRMYRRTLRPYGAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M3CV55</accession>
    <name>M3CV55_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor SLU7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_152333</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SLU7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF08032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756153.1">
        <property type="nucleotide sequence ID" value="XM_016907383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CV55"/>
    <dbReference type="STRING" id="692275.M3CV55"/>
    <dbReference type="GeneID" id="27904520"/>
    <dbReference type="eggNOG" id="KOG2560">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019317_3_1_1"/>
    <dbReference type="OMA" id="KYAWESQ"/>
    <dbReference type="OrthoDB" id="249612at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030628">
        <property type="term" value="F:pre-mRNA 3'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021715">
        <property type="entry name" value="Slu7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039974">
        <property type="entry name" value="Splicing_factor_SLU7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12942:SF2">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SLU7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12942">
        <property type="entry name" value="STEP II SPLICING FACTOR SLU7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11708">
        <property type="entry name" value="Slu7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor SLU7" evidence="9">
        <location>
            <begin position="127"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="160"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="220"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="422"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="220"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="425"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="464"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF08032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="491" mass="55749" checksum="591DFD74C2E4B8CE" modified="2013-05-01" version="1">MPPNPASGSTKKDTPKSNDRNEYIPSFIAKKPFYIDDSTVSSDADYLLHQRLQNDSQKEKDSLAAAQWYERGSKKGPAATKYRKGACENCGSMSHKEKDCLQRKRKKGARWTGKDIQADEVVGKVELGWDAKRDRWNGFDASEYREVIEDYEAVEAIRRQAAKKENGEEEDEEGDEDGDKYEAETDMGRKQATSTRNLRLREDTAKYLVNLDLESTKYDPKTRRMLENKGGDPNSLDADDGFAGKQSGDAGEFEKASTYAWETQERGDKDKIHIQANPTEAQLKRKRKAEEDIQKAEAKKKMLAEKYGVQDTSTSNKTAQLAATGITSNERYVEYDERGRIKGEAEKKEKSMYPEDVYLNNHTSVFGSWWKEGQWGYQCCHSVVKNSFCTGEEGKRAHEESEQFSRGLMIEATPVEVDGETAAAEEAREEKHIPNGVDRPEKQIQDESRRRMEELQAGGVTEAEMEKYRREKTNANDPMAKMLGKDELLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M3CZN0</accession>
    <name>M3CZN0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_121011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF09131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757252.1">
        <property type="nucleotide sequence ID" value="XM_016901654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CZN0"/>
    <dbReference type="GeneID" id="27898791"/>
    <dbReference type="eggNOG" id="ENOG502R6MR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065388_0_0_1"/>
    <dbReference type="OMA" id="WHDEWTR"/>
    <dbReference type="OrthoDB" id="3645916at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="330" mass="36600" checksum="EE0ED07A9A154F08" modified="2013-05-01" version="1">MAALTVEHHFTGDRKLLNATIDRRNNLRSALTALHQDLQQLEGHPVQIVATINFNVLSRPPKSYVYTVDVTDSHFDPDSFAATTTTNPPSAPLPAPTDAGSSRSAGAASTSRPRDHADPRPTKRARTDQPSTGDGSASTSALSTVPQRLDDLHTFMKTWHDEWTRQGGWLFDSINAIGKAQKADLDHVEKKLDTMQDVIGLSINSACATNMTELSNISKLIPWLEHCRKTSADKVHAREEKWRSSSATFHHESRKEREAAEARLEKKLEAQRHILIKLAEMNGIDVVDEDEDHQDEDHNNVDEEDDEKHSEASLGAQLTAELNSAAQRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>M3CZN9</accession>
    <name>M3CZN9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Ketoacyl-synt-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_166720</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF09141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757262.1">
        <property type="nucleotide sequence ID" value="XM_016908252.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.M3CZN9"/>
    <dbReference type="GeneID" id="27905389"/>
    <dbReference type="eggNOG" id="KOG1202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_31_0_1"/>
    <dbReference type="OMA" id="PDIMSAM"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000209">
        <property type="entry name" value="Polyketide synthase Pks12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF29">
        <property type="entry name" value="ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23297">
        <property type="entry name" value="ACP_SdgA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="10">
        <location>
            <begin position="6"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="11">
        <location>
            <begin position="961"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="2351"/>
            <end position="2429"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="8">
        <location>
            <begin position="961"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1126"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="8">
        <location>
            <position position="993"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="8">
        <location>
            <position position="1191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF09141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="2441" mass="266378" checksum="2E7435147245818F" modified="2013-05-01" version="1">MPGVQIMPVAIVGVAGRFPGDASDPDKLWSLLTHGRSARSKVPEDRYIVDAHYHPHAERLGAQNFTTGHFMHRDPAAFDAPFFQITPNEAKALDPQQRMLLEVAYEALENAGIPMERVVKSPTSCYVGCFTRDYGDILAHDVQTTPAYSPTGASASCLSNRVSWFYDLRGPSMTVDTACSSSLVALHLACQSLRDGESEMSLVGGVNFMCSPDCNNSMSSLHFLSPDGKCQSFDEKGNGYARGEGTSFVIIKPLAAAIRDNDVIRAVIRGTGSNQDGLTPGLTLPSSEAQAQLIQSTYERAGLSLADTGYVEAHGTGTAAGDPIETSALGATLGKARQRDRPLWVGSIKANIGHLEGASGIAGLVKAIYILEQALIPPQIWLDRLNPRILADEWNLAFPRKLTAWPYDGLRRISINSFGFGGANAHCILDDAYHYLHQRSLGGNHNTKINHQEVRPMLHRHTKSFDSVISDAMWPKPSQATPCLTILSSHEQSGMSRLVEVYRGYLETKMRTPESAEDQADMYSRFAYTLGTRRSVLAWKSYFVAATFDQAYDSISEMSKPVRSTKPPKLGFVFTGQGAQHFEMGRELYAYQVYARSLEDADAYLRSMGCEWSVIEELFKASEVSNVDKPDFSQPLCTALQIGLVDLMRHWNILPAAVVGHSSGEIAAAYAKGAITREDAWRISYHRGRLSAKLDEIAPDLRGAMLAAGLDAKAARKYIDEVRRGRATIACVNSPSNVTISGDESAICEIEEQLKADEIFARRLKVKTAYHSFHMEAVSQLYLEALEGLSPSPEDAEMPMMFSSVTGSLIRSHELGPQYWVDNMLRTVNFAEAVESLLTYTKSKRVRAGSKPYVDVLVEIGPHGALQAPIKQCLGEKAKMCTSLSVLTRGRNSATAALETAGALFQLGANVDIGAVNSPDWKPKRQQILIDLPPYPWNHENKYWHQSAVEAAHRFRKLPRNDLLGTLSTELNRDEPSWRHFIRLSENPWVEDHMVQSTLLYPAAGMMAMAVEAAAQIADHNKGGVEGYELKDVLVDKALIVPRDEDGVEAQFHLRPWRMGSQATTSAWHEFTIYSRSGNEEWSLNCSGLLRVVYQGSAPNATFADETRLESSKHRAAYERAKEAATTHENAAHFYDRHQKLGLQYGPTFRNLFDIWKGDRLSSCLLRVPDVAETMPMQYLTPHRIHPTTLDTLIQTLMPTVEGTYQNIETAAVPTFIQRLYVSADCPSEPGTVLQTYSVAGYSGLKEAEASVYASIEGWVKPLVILERIRATRISAMTSTIGNAASSNANLRKIAGELVWERLASAMSAEQITAYCRGPGKRSANAQLAAYLRLLGHETPGQKILEIGCQSVAVSEAALGLLVSSDDSTPWFRSYDCVGDWAKAPQDVAALIEAHSQHMSYNQLDISGDLAAQGFDQGEYDVIIISDCNEISDLPTALRNAISMLRPGGNLVVGDQMVNAALGPAINGTIKHESDSNIDKKAWNDHLREAGFEGVDRMLVDDSSAEPLVSVYTIATSQPLAPSLPDQILIVEPLARGGLSSQALSDKLADHLRSMGSNVSTVELKDVAKLDLADKSCIVMIELESPLLYGLEPHDFEAIQTMLLTSSSVTWIAQGGAIECNDPKSALITGLARTLRQEHTGIKLATLDLPVTLELDFVMNVEAIIQVVKTHSLDTSDQEFALRDGVLRIPRLDVDKGANDLIATFHSEPVPEPGLFRQTDRALTLSVKVPGMLDSLYFKDDETWVLPLEANDVEIEVMASGLNFMDVMVAMDQIQEPAIGVECAGVVSRVGSEARKYKVGDRLICWRLGAFSNFVRNHEMMFQPIPDGMSFETAASIPAVYCSAYSALIEEARLSSEDTILIHAAAGGVGQAAIQIAQHIGATVYATVGSQAKKDHIVNTYGVPEDHIFNSRDLSFATGIKRMTNGKGVDVVLNSLAGEALRESWNCLAWFGRFVELGKKDITGNTGLEMAPFIKHISFHSVNVIGMQRVNMPRAARLFHNTMLFFRQSNCQPVSPIQAMGFDEVESGFRLLQSGKHMGKIVFKAGSSQMIQCIPRKVREAQFDPNATYILSGGLGGLGQSLSTFMVSHGAKNLAFISRSGAAKPEAQSIIDTLASQGVHARAYACDIGDSIKTQETLATIQAEMPKVRGIIQAAMSLADSAFANMTHAQWNLSVNPKAPGTWNLHQHGPKDLDFFIMLSSSSGIAGTRGQGNYAAGNTFQDALAHYRRAQGMYTVAVDVGPVSGAGHAFEHPEILESLSAQGYVPLLESEFLALIQAAVTGETASGITMPTQLVTGFITGGILQSEGREMPFYLDDPKFHHVRLVDARSHDSIDANNSFGSQLPSAQNLTEAAEIVTAALAQKLAKLMMVSDEDIDTGKPISTYGVDSLTAVEIRAWTFRELQSDVSIFDVMSNVPISNLARTIASKSKLVSVEVVAADM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M3D0A6</accession>
    <name>M3D0A6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_120028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758435.1">
        <property type="nucleotide sequence ID" value="XM_016901563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D0A6"/>
    <dbReference type="GeneID" id="27898700"/>
    <dbReference type="HOGENOM" id="CLU_839824_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF10314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="331" mass="37044" checksum="97C9EBFC1C15B2E4" modified="2013-05-01" version="1">MADDEVEFHYMYLHISLHLSVPNINIHIIHIIHFTRFQHQLSSMRFTAALILSPSLLASICAAVNLRFSGCQPRQQKLLNEAFLIAREEVNLIQEFSPGAPEIADPPDLSAKEVERLKIRYFGYTTKDDTAYGTVTWICAQHDDELDRQCQKFGAAAYTQQGTEIVMCAKETGKQGTSSKRHRAGVMVHEMTHIKAVSGNRTIVDVLYNERKVKEAGLAPVNVTAVSSQTLEKGCYGNDRVRKLAKWSPSLAVLNADSYGVFTTQLARHENAKKLTWSGLMDAINIWIEDHPLAAASIIGSAALGLFLLFLLCACCWHRMKTRRHPGRPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M3D0C9</accession>
    <name>M3D0C9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_150039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF10988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759109.1">
        <property type="nucleotide sequence ID" value="XM_016905927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D0C9"/>
    <dbReference type="GeneID" id="27903064"/>
    <dbReference type="eggNOG" id="ENOG502SR19">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062455_0_0_1"/>
    <dbReference type="OMA" id="EGGFGEW"/>
    <dbReference type="OrthoDB" id="5420711at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF10988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="406" mass="45893" checksum="AB0DF00175F6AEB2" modified="2013-05-01" version="1">MNLKEVLNWTPSQHVITTSSISGPFNACRGDLDGPHRASLLISHTSCREHHETFANNSDPPAHRSSSPNDHRILHPSVLPTMSSTSVAEHPPRHPTASPFLRLPTELRLQIYSLLLFPRQSTDLLCSWDKLDASAVDAVDYDQWGIQDGVVTPDPLNHPTLRIRSVDPTKYQTRFANRPHTRTSYSVRADRFANRCMATTYHCVNVPHIGDNLAILRTNRQIHAEAAELMYSSYTFDFDTHIEAIIPFLRDLTPLARSYVKNIRLTKRALAYIKEFDRCEWENAWRYLTNAENNINIRRLELAVIAGRPGDNGWDGVATYSAADFNLLKTQEGMEWLQYVEEIGPVQELEVQAIVEHCPSITSSNAMASYVRFSASVEAGFAEYLRGRLLAPEAQRRLAGSEPCWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M3D0F1</accession>
    <name>M3D0F1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_51021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF09953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758074.1">
        <property type="nucleotide sequence ID" value="XM_016909180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D0F1"/>
    <dbReference type="STRING" id="692275.M3D0F1"/>
    <dbReference type="GeneID" id="27906317"/>
    <dbReference type="eggNOG" id="ENOG502S5YZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040048_2_2_1"/>
    <dbReference type="OMA" id="RICETCF"/>
    <dbReference type="OrthoDB" id="2687876at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="45"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="166" mass="19017" checksum="E105276A19420454" modified="2013-05-01" version="1" fragment="single">MTTASYEAQTYPRLNLKDFTLDENNLERDCPLDNGRHQKLPEYDLGTLDSLPLEILQEAISYLDFDTLAALRRVNARAMEVVESVPAYRATLQLCPNIVRGLYSIHYGAYVSLNTLWSTLGRARCEDCGDFGGYIYLLTCRRVCFLCFRTACRFYPLQIAEASKQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M3D149</accession>
    <name>M3D149_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_143951</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758339.1">
        <property type="nucleotide sequence ID" value="XM_016903059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D149"/>
    <dbReference type="STRING" id="692275.M3D149"/>
    <dbReference type="GeneID" id="27900196"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011025_2_1_1"/>
    <dbReference type="OMA" id="YLWACAL"/>
    <dbReference type="OrthoDB" id="413885at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.410.10">
        <property type="entry name" value="Cholesterol Oxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053208">
        <property type="entry name" value="GMC_Oxidoreductase_CD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47190">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47190:SF1">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="2 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="261"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF10218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="535" mass="56884" checksum="91806D8CFEECEDF5" modified="2013-05-01" version="1">MDCTYIYDVEWDAIIIGAGPAGIVAADRMSEAGKRTLLLEQGGPSYYSTGGRERPDWLSNTELSRVDVPGLYSSIFSGSSSLLCGDKQTGGFGGCTIGGSSAINAELFSQPPASDFDTYYPQKWKSENMAGAIEKVKAMQPFTNTPSADGKRYAQSGYDATRKWLVDSVGYKSVAVNGDPNNKNGVFGRANYAYQNGQRSGPVKTYLQSALGRSNFSLRSGVQVKRVERDGSKATGVVAMVDGQSTTFKLSGNGRVILSSGSFFSPQLLMLSGIGDPASLSGLANNQLLDMPSSAWINNSAVGDHLYDNPNTFLVFSGTNIQSYNFDYSSPIATDKDLYLQSRSGPLSSAGPTGLFWDSVKQADGSSIAVQGTVNVAGSFNLTGPDTFTINVYATSGAKSKSKVILSEKGIPGPASDFLYSDPADADAVATVIYKMFQSFPQTGLTSLNLPVTSSKAEILQYITTPSDFTKGYVNHWSGSCKIGTCVDLDTKVIGMDNLHVVDSSITEAFTANPIFGIMTVAERASELILALDQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M3D1I6</accession>
    <name>M3D1I6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_150313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759479.1">
        <property type="nucleotide sequence ID" value="XM_016906084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D1I6"/>
    <dbReference type="STRING" id="692275.M3D1I6"/>
    <dbReference type="GeneID" id="27903221"/>
    <dbReference type="eggNOG" id="ENOG502T0SF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1078356_0_0_1"/>
    <dbReference type="OrthoDB" id="3915580at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF11358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="258" mass="28211" checksum="20B4F1CF0232E445" modified="2013-05-01" version="1">MPPVPPNTAQHSAIPSQPQTPSTHCSSEEDESEAPVEIRVKGVLADSSKPYSTDHTRAATPIGYFLAPPRSNSLPASPSIPRQLSNLPFEELQFLSHRDSVEIARGQMRRELLDRQHRERPNSLLLATRDSYGLTKNKFDTIHPATAAPEVHGYLTPTIPSIQWTRFGGLSPIADGSPPNEGIWRLGKQNGTSPLGSSPRLSPRSRVGSPAGSDQVSGSGPLQERVEHLEERMRILEDRLISVEEGRRLSNGDGGEAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M3D1K2</accession>
    <name>M3D1K2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_157155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759133.1">
        <property type="nucleotide sequence ID" value="XM_016907721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D1K2"/>
    <dbReference type="GeneID" id="27904858"/>
    <dbReference type="eggNOG" id="ENOG502TKFR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033838_0_0_1"/>
    <dbReference type="OMA" id="YWTGRFS"/>
    <dbReference type="OrthoDB" id="3557758at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF11012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="579" mass="63951" checksum="E50551C3D29052DF" modified="2013-05-01" version="1">MLARKSQSHETPPESRRSSLRRLSSIASLQSLMHQFNRRRSNNTSSNPEHSPSTTTSILSLSSTAANAPDRKRDGNKSDFSGESDGFDHAPPVPATLPTRRGSYICLPDDPIGGMPRSRTFSNLPLPSRAKKSAASKLQLSKSHARLPLHTNDEVPPSRLPTPTFNLRKQSTSNRLVPVDDKTRKKLVRSDTVPLLQNGLQREPSVPRMTAFKENISLSPIKPLTPYDENLFACSSRQGWSEDSERDVAVFTERKASLANQKRLDVSHSGPNSMRMTQKSDSSPAYRSTKERAPTPGKPVQRWNSQPVLTNTTNVRNSYGAAIKQTRLMSARQAPTPPPASSPSTEVLLKATRTTRGFSNSSGHARLSSSQTSVVMQERPQRTSRARAESVKLKPGAVGHFPAVPSPHMLIYCQVLTAQPAAYWTGRFSSLNDRFRNEELAATDLSGEHVSKSDTDRIHTSEANSLRMRRAVEQLFSLCATVEAEQSFFMWQKAVAKALALPELAKPLESNWSSSEVRTCALEMSLRGDEYTPSPPPPSEMRKTKFMDRLLGRRQKVGHVSDRAHVVAPVEAAVVGGFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M3D380</accession>
    <name>M3D380_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_149290</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Siderophore biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760811.1">
        <property type="nucleotide sequence ID" value="XM_016905466.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.M3D380"/>
    <dbReference type="GeneID" id="27902603"/>
    <dbReference type="eggNOG" id="KOG1178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000092_1_0_1"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000024">
        <property type="entry name" value="Nonribosomal siderophore peptide synthase SidC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF2">
        <property type="entry name" value="FERRICROCIN SYNTHETASE (NONRIBOSOMAL PEPTIDE SIDEROPHORE SYNTHASE ) (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="425"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="1616"/>
            <end position="1692"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="2181"/>
            <end position="2255"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="2776"/>
            <end position="2850"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF12690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="3377" mass="371007" checksum="F437DCEC87275E52" modified="2013-05-01" version="1" fragment="single">MILVDVVTSGTEPLDFLAPVPLLAEHLAYLIWTSGTTGAPKGVMVEHTAAFHAMRALQDAIPTSVDESTGQYCPPRVLNFCAYSFDVFVQDLFYTWGLGGTLISSTREIMLGNFVQLAVEMQATHAHLTPSFSASVRRQDLGESLQVVTMIGEKLTESVANDWSWHTKAFNTYGPAENAVVSTLRQFGNSSDDNAKAANVGWSLSSVSSFVVHPDPPHHLVPFYGVGELALGGHQLARGYLNDPVKTQSRFVWSSDLQQRIYLTGDIVRMVDHGIEFLGRNDDLVKLNGIRVELSEISATLSQTHPDIEHIETLLLTHPDRPVKAVVSFTSLRNDAADAPLVALDKRAFSARAEILTAAHQLLPDYMVPSFFIPLNRMPRTASNKVDRKVLQNEYESLDLSQFDTSSYLLSTAPKTGDRGTKVRTPIEDRVVIMLSELSGLDPSAITDGMSLARLGIHSISAIRLAWRLKKEADIDVAMVTLLTCSTIGQLLSKVSESTADNAHGGDNQDQAAQWLDSIERQLFDEFAVQVQSQASLTDQVINAIRPVTTMQEGLIIETLRNDRSYWSHRMFRLPDGVDTTRLRAAWEQVAQDNEILRTGFLIAAEIDHNAPTLLKSQGIQSAVLQAVTSPAVVRWSEVEWDPSSYPLATIGDELARRARNEASPIASSKLVSPWSISILRNSATREAALMMHIHHALHDAQSMDAIFDDVFNHYYQHSSRVPSRTQFSDAIRRGIYLSPVQTQNAQQHVSELYSGLVKQFGPVTTTKWPDMTGSRQLQERRILRTTVMIGPTNASETWKRLQAAKAKYALGAPTRIVSAAFGCVVAEYLESKYIVLGETVSQRLHHATLQSVLGPLVATVPTAVRIDLSASETLSNATSTTTVAGGALHHVHPATLRNTLGITSDQPLYPALIVFHPHVDEEFDEKQSSAFWDEMDDIVGLCVEHPLALNIFEEEAGLRVELSGDNQAMSQHQLDMLIAQVMSQLELMLAQPDVPLEELNNVLPPSLLSVTPATKVSMRHLDELVQKEDWANIAVPTINPVAWVEYHARHHPEWIAAEEILDVDEPEQTRRWTYSQLLSATSRVLATLQKRGIARGSVVSIHLGRTLESFAAILALFRGGYIYLPLDEELPAERTRLLTVDAGARAFITTQDLLNELMDEKQMSWRGNIDLVMLEDISHIVDATPSLPEYTSASHSTDDGYILFTSGSTGKPKGVRVTNSNLCNFIECLARQILDNSPETKHLGGVGKYLNLASRAFDPHLTHMFMAWRLGLAATIGPRMMMLGNLESVIVQNSITHFGTVPSVLQQARLSPERVPSVVFVTVGGEKVSNDVLAMWTEGDESERPRPLMMNVYGPTECTIGCVSNIVTRSSNARNIGQVFDCATAIVLATQTSGAEGEPIIAKRGQTGELCIAGDLVSLGYMDRPEAQAKAFATMDLLPAAAEDGSRQTMRYYRTGDLVRMMSDGCIEYLGRSDQQAKVNGQRLELGEVEHFLRRTAKELHLDVEFAAAVIQHPDLPRPRLYAFIASLSTEDPAASEQNLGAVASDPEILAQLSDACSKSLPAFMVPDLVWINRIPFMKASGKVDAKQLNALVRSLPLSKLHQDHDDSGQQEASQALTEDEEIVVKAIEGIVGSSIGRPEANRSIFELGVDSLSAVHLSARLKQLGLQTPAAHNDLATAIRQAEERLDLFDRAHRHNLVGDADHSVDHVLPTMPLQSALLARSMAQIEDDEDASNGVLYVSHFRYSLAHSTDLQRFIGAVERVLQEEKMLRTCFRQTTTGAIAQVVLSQSPVSDLVIPVQSSWESWLASHSPNTIAHALVRDVARLPPVRVHIFEGQSGEVLLSMHHSLFDGDAIKQIRLRIQELYNGEVCQETSAAGLVQLVTQFEATDLQASQAFWERNLLHAEPCLVVDDDIASSSKETDSTCRSTKRLLLPLAQLRSAAQANNTSLNAIFQTTFALLLSELHPLRSEVVFGCVLSLRPLLSSDIHGTAQLIAPLLNTLPQRVQLSLAAQNGGPLRHLGQAVRENLSETMQHAFVPLDRILKWCQLDQALFDAIISVNFHTNQHDSESGTGPGAQPGSMILMDTLSVANIPFAADVNVHDDPLGNSYVEIELSSSAAQFDVDRLSGLAKRFDELCTTLVESPQMPLTSLLPSLPTTVGPAALSDSRDHEMHDSSPWSAEEELVRDVICELLNIPAESLGKQQSFYRLGMDSILVLRMVKLLRERTGVKLSPLAVLRARCAASVAQLISAAEIAQSSDSALKQQQELDDYTRTLQTLSGTVAGDFGVESTFFATPIQQGMLSAGLSSTDSTNHLVSPYIYRHTFEVDNRSTFDVGAFQQAWKRTVVETEILRTTFHFTDNKSQPWLGVVRRLQDNEAGVVRVFSSSREAACAPFDIDVSTCLAHCALVMPPSMSEPIMVVFTMHHAIYDGASLPLLWRTFIDIYRAVSEGRTFATLPQISFSSVARQVAVQQSSAVKYWVKNLNGYTYEPLGPRIVDDREQEASNKINRFRSFAHIPLEQYENVKRRCQELGVTVQSALVLAWSKVLAHDILGQSDVAFGQVLNGQFLALGGEEADHQQVTGDYVIGPTFNTVAMRVALDPALSNRQALEKIQKLSEEAQHHQVASLRTVQNEWRSSTSAGHASNLFESLFLFNGENTSLGSQPASQQPFWKPSKLKGEGDEDGFAEYPVVCNLSISQAGLHVQVSAASDRFDNAAAGRLSASFIKALIQQMKDVDMPSIASGMALQKAGSTGTTERLDSNDGLTPEDQALYQTVLDAVHDVLRIAEDKGSSPGVDAHTNLFRVGLDSILAIRLSSKLRRTDVALTVNEIMQGKTVAAMVAHKCQTAAKKDKQSALIGQAQDFASPLSRDQQLAVTAELGWAPDEVESVLPCLAGQEHHLEYWMFAGRRFFEAPWIYKLRLPVSVSDVQRAWDALRRRHAILRSTFVAHEVHEKSQPSVVQVTRTAHYVDGARDGTFTVLYHSGSATLDDMIEQHLLETNDKSSDLRSPPVQMTLVQTCSGEAAIIMRFHHAMYDAWSIRMLLRELDQLVQSDGPLHKPVQFAGAVKDIFGQRNLHNEHVSWSQALGSAQTSILSPSEKADNAHTGPLGPQHLVRLPSVVSAATLRSLETLSQTKANSSLSPAILFAFAQAVAENLDAPCSSPTFGFYHASRSLGSLDLTQVVMPTLTLTPLSVQVGSMEDSNNDSAAAATAVMDAIQGVQNYLSQLSQHGQASMHDILKHINRPDEEGPLFNSYINLLYRDSSSSSSEEEEKATVTAPLTVLEKFKPSRNTYFTESQPTEMGEETLPHLQGLNTAHIAPLRIFVDVVIDRSGEGVSLGIRCDCGLYDVESVRRFAQSFVEGILRLERMLLALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2022-12-14" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>M3D3S4</accession>
    <name>M3D3S4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_117407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760981.1">
        <property type="nucleotide sequence ID" value="XM_016901337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D3S4"/>
    <dbReference type="GeneID" id="27898474"/>
    <dbReference type="HOGENOM" id="CLU_1918403_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF12860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="132" mass="14395" checksum="AC2FA1E6953F6A4D" modified="2013-05-01" version="1">MTGSVAARDRDDVGGGDAPGNGNMSPPHGSRWADDGQNGDMMSLETEAVPLEEAYPAPLLRVEEHPRLQPISKSMSEDHVAVDIEVFGGTWYGRSIGRQQTYRPPLDLGMKSQVRRDALKLPDLLSPYTAYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M3D4E4</accession>
    <name>M3D4E4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PR-1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_117318</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760880.1">
        <property type="nucleotide sequence ID" value="XM_016901323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D4E4"/>
    <dbReference type="STRING" id="692275.M3D4E4"/>
    <dbReference type="GeneID" id="27898460"/>
    <dbReference type="eggNOG" id="KOG3017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035730_5_1_1"/>
    <dbReference type="OMA" id="TITDLWY"/>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05380">
        <property type="entry name" value="CAP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002413">
        <property type="entry name" value="V5_allergen-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00838">
        <property type="entry name" value="V5ALLERGEN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032812" evidence="1">
        <location>
            <begin position="17"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="26"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF12759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="197" mass="21970" checksum="0C716D3FABFB7540" modified="2013-05-01" version="1">MHFLGVAAIFSIAVTARPAVVPRQLSYAEKAVLHHNYHRANHSAPPVEWDDDLAATAKKGADMCSFEHKMDFDGGGYGQNIAAGVEPERITEIITGLWYNNEQCLYPSYGRNPTEDEMTNSFHEWGHFTQIVWKDTTTIGCWTTDCTSQGGVKNVGGDVLPYFTVCNYKGPGNYDDEFADQIGEPLDHDTVQWDYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M3D4J7</accession>
    <name>M3D4J7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA 3'-terminal phosphate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_148518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761261.1">
        <property type="nucleotide sequence ID" value="XM_016904971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D4J7"/>
    <dbReference type="STRING" id="692275.M3D4J7"/>
    <dbReference type="GeneID" id="27902108"/>
    <dbReference type="eggNOG" id="KOG3980">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027882_3_0_1"/>
    <dbReference type="OMA" id="HAKTARW"/>
    <dbReference type="OrthoDB" id="25029at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003963">
        <property type="term" value="F:RNA-3'-phosphate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023797">
        <property type="entry name" value="RNA3'_phos_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037136">
        <property type="entry name" value="RNA3'_phos_cyclase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000228">
        <property type="entry name" value="RNA3'_term_phos_cyc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096">
        <property type="entry name" value="RNA 3' TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096:SF0">
        <property type="entry name" value="RNA 3'-TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01137">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="EPT/RTPC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF13140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="418" mass="45712" checksum="410482A00D24FAC9" modified="2013-05-01" version="1">MAKPQVRQKELVVLDGRTLEGGGQLVRIAFCLSALTGTPVQVNDIRGKRSGSGGLKPQHLACVQWLAQACNARLSGAEKGSKTLTMAPGQGQPMQSGLPSVFQKSSSLGDETRPFYECHVDIGTAGSTSLALQAILPFLLFAKLPTESTIYLRVSGGTNVSGSPSYEYIRYVLLPTLARIGFPVMQVVLEKRSWNQGASGIGSFTLQIPPRSGMPLPAFRYAPQTLTAAPAKPTNLRAIFIAPSSCHEHFRKILLPALVHNFGHCILPDTSSDSNKKLMIECEDSQHDKRMYFILIATVPSADEKCSSYILARDWLYERKISCQLRATTEMVEGVTKNLAEEWCSGTWVDEHMRDQLVIFQALAQGRAEVFPGWKDGDMERLREASLHAKTAEWVAKQILGVTFDRGGYCEGAGYGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M3D874</accession>
    <name>M3D874_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_148083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762466.1">
        <property type="nucleotide sequence ID" value="XM_016904690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D874"/>
    <dbReference type="STRING" id="692275.M3D874"/>
    <dbReference type="GeneID" id="27901827"/>
    <dbReference type="eggNOG" id="ENOG502SV1A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073382_2_0_1"/>
    <dbReference type="OMA" id="SHICYID"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053201">
        <property type="entry name" value="Flavunoidine_N-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12350">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12350:SF19">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF14345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="23772" checksum="2DB7A29452DC1BFA" modified="2013-05-01" version="1">MTQTQTPINGTANGTAKPFEKDSRLSTESAYDLTINHLQDLVAFKDTPAGLCLVSKVALPAGAHFAYLTSHQPQPRASWKTIQTSKTTHTDPQSALLYMNHSCAPSLEVHTYSPDANGKYPQTPQHGGDLNGDAAGLTSVGLAGEVRVSRDRAVQVGDSLTFFYPSTEWKFDRAFDCLCGAGEGVCVGKVEGASAIAKEDLGRWFFNDHILELARERDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M3D8M0</accession>
    <name>M3D8M0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tat pathway signal sequence</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_148172</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762591.1">
        <property type="nucleotide sequence ID" value="XM_016904755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D8M0"/>
    <dbReference type="STRING" id="692275.M3D8M0"/>
    <dbReference type="GeneID" id="27901892"/>
    <dbReference type="eggNOG" id="ENOG502SR3W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042941_0_0_1"/>
    <dbReference type="OrthoDB" id="3644465at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF14">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF14470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="344" mass="39836" checksum="295EC03A6D90395D" modified="2013-05-01" version="1">MWWLMTRWTRSQYTAISQNSLLTEDDPEIGDALKEGREREVRRKWQIKPAMKCNFSGVLILVAGAALLIALTIQCTIWYLLSRGMPGLRPTEFSPLYRLFNNIHYEIATIRTGHLATADAPDHIYRQPQSVEVHDAWVNLTDTAIFPITRNEVIRLGKDPDYAVKAPEEWGWPKDSYLASLEVFHHLHCLDVLRRNLLHHYHVYWGVRFGFSPNLVWTWHLTHCLDILRQHLMCNADTAMFIYSYVEGQTEPQGDFTVQKKCINFDQIHEWNYKKRQDNLLHSHEPPWRSRVAPIKELPPAPGVPRITNETVYVDYGDGLSVPTGVIPGLEGKEYCLGEIGEYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>M3D9M5</accession>
    <name>M3D9M5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_148245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762695.1">
        <property type="nucleotide sequence ID" value="XM_016904798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D9M5"/>
    <dbReference type="GeneID" id="27901935"/>
    <dbReference type="HOGENOM" id="CLU_2062926_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF14574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="119" mass="12806" checksum="5F54C381AF3BA999" modified="2013-05-01" version="1">MRPAMVIVCTQFSECAPSSLLLGAEPGMLMFHIHALAWEEHRGRGRSAVQQSLWVTAWILPASGIIWLQHNATEVPTGSGCVTLEPAQSICPVPPDCPPLHSLHCLPRVVCLSTGTTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M3DAG6</accession>
    <name>M3DAG6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_113995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF14859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762980.1">
        <property type="nucleotide sequence ID" value="XM_016901067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DAG6"/>
    <dbReference type="GeneID" id="27898204"/>
    <dbReference type="HOGENOM" id="CLU_1511512_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF14859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="178" mass="18858" checksum="C764C918CF31777F" modified="2013-05-01" version="1">MDLVSISVVCCPECMVPLAGEDGFHIVLVLVLALALALALVRTEIERRASLDEGLDTGVEDSAEREGLCMRDKMLVGAVARKVEARRRVANIILQPVGRYRERGPAAEEGAIEDVLGVTVRPPDNGSNTAHIVAYAAVAGDRAALLAHIVAGDGRARIVHQLPPETDDLAYCRLSGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M3DB77</accession>
    <name>M3DB77_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 6</fullName>
            <shortName evidence="5">eIF-6</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TIF6</name>
        <name evidence="6" type="ORF">SEPMUDRAFT_130859</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleolus</location>
        </subcellularLocation>
        <text evidence="5">Shuttles between cytoplasm and nucleus/nucleolus.</text>
    </comment>
    <comment type="PTM">
        <text evidence="5">Phosphorylation at Ser-174 and Ser-175 promotes nuclear export.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763225.1">
        <property type="nucleotide sequence ID" value="XM_016902383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DB77"/>
    <dbReference type="STRING" id="692275.M3DB77"/>
    <dbReference type="GeneID" id="27899520"/>
    <dbReference type="eggNOG" id="KOG3185">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071894_0_0_1"/>
    <dbReference type="OMA" id="WCAFCGM"/>
    <dbReference type="OrthoDB" id="71302at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902626">
        <property type="term" value="P:assembly of large subunit precursor of preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00527">
        <property type="entry name" value="IF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.75.10.10:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.75.10.10">
        <property type="entry name" value="L-arginine/glycine Amidinotransferase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00032">
        <property type="entry name" value="eIF_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002769">
        <property type="entry name" value="eIF6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00323">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10784">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01912">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006413">
        <property type="entry name" value="IF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00654">
        <property type="entry name" value="eIF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55909">
        <property type="entry name" value="Pentein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="3 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="modified residue" description="Phosphoserine; by CK1" evidence="5">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine; by CK1" evidence="5">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF15104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="245" mass="26336" checksum="C8C53C54E1DEE2BB" modified="2013-05-01" version="1">MAVRASFENSNEVGVFSTLTNSYALVAVGASENFYSVFEAELQDVIPICHCTIAGTRIVGRLTAGNKKGLLVPTSTTDQELQHLRNSIPDEVKIQRIEERLSALGNVICANDHVALVHPDLERETEEIIADVLGVEVFRQTIADNVLTGSYMSLSNQGGIVHPKTSIQDQDELSSLLQVPLVAGSVNRGSPVVGAGMVVNDWMAVTGLDTTATELSVIESVFKLGEGMGPSTIQQNKNSMVESFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M3DEE2</accession>
    <name>M3DEE2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Palmitoyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_124249</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="10"/>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF16170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764291.1">
        <property type="nucleotide sequence ID" value="XM_016901901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DEE2"/>
    <dbReference type="STRING" id="692275.M3DEE2"/>
    <dbReference type="GeneID" id="27899038"/>
    <dbReference type="eggNOG" id="KOG1315">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024136_0_1_1"/>
    <dbReference type="OMA" id="GEFRFCK"/>
    <dbReference type="OrthoDB" id="302728at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="242"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="12">
        <location>
            <begin position="152"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="335"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="465"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="545"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="571"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="581"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF16170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="592" mass="66809" checksum="9645D1DEE104798E" modified="2013-05-01" version="1">MPTLATTHRSSTSTSPSLHRRTKSFARRLERCCCATFAFFPLVFVYGLTTWAVWVEANVSFVGRNGTGAYLRAALGILLYALADISYTIAVFSPPGSPLDDQGGPRGRKGDYQGLPTHDEYNHGARLREEGVEPVPREWEWMQNSVTAKSTGKPRFCKKCQCVKPDRTHHCSTCGQCVLKMDHHCPWLATCVGLRNYKAFLLFLLYTSLFCWTCFGVSAWWVWEEFNERAEGLQGMLVVNTILLSVLAGVIGLVLSGFTAWHVYLVVSGQTTIESLEKTRYLSPLKKSMEGQFKDPTRHNLAHDATPITNAVETGQHQPLTDRLKEIHANALPGVLRPEEGESGATSRTPSPLPPVAANGGPLGSSPAQQSLNRTYASIEAQRERERYNSYQDEVDSERLPNAFDLGWKRNLLQVMGPVPWKWPLPYLNTVGDGWSWEVSPSFWEAKDRIAREREQRMREDALWNREAHQQQPPWQPPPRPKWIPGQGFVDQARNAALQANERSRSGEGPSPSMQMQPLDRRKRGEDEAGVVDYDTSSDEDRFVQKQQQQQRQQRFTRTENWNDIPEDFLAATTTPTASTKTRRSGSRTKGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-12-14" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDT6</accession>
    <name>N1QDT6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_151646</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757851.1">
        <property type="nucleotide sequence ID" value="XM_016906952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QDT6"/>
    <dbReference type="GeneID" id="27904089"/>
    <dbReference type="HOGENOM" id="CLU_1928915_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF09730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="131" mass="13245" checksum="EE8C4C42E15138C2" modified="2013-06-26" version="1">MRGPVIYSHTQPEARRLIPSTSPLLSNRYIERVSGCSVPGGVDRNASAHTHAAAAAAASPAIAGAGAGAAPAASSTLLPALAHIIIPAGKAHGLGPASATTHKRRPHPAVPLLCTLFPPHIQSRSSTYIGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1QEQ7</accession>
    <name>N1QEQ7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_46721</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759729.1">
        <property type="nucleotide sequence ID" value="XM_016909010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QEQ7"/>
    <dbReference type="GeneID" id="27906147"/>
    <dbReference type="eggNOG" id="ENOG502R89D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3056154_0_0_1"/>
    <dbReference type="OrthoDB" id="5421058at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF11608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="54" mass="6219" checksum="E938FA727E54AAC4" modified="2013-06-26" version="1" fragment="single">YLSSYIGALNRSYVPFKPKLVKNASAYRNRKGGLSQNVLVYYNFNSYYTFVLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFA8</accession>
    <name>N1QFA8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Acyl-CoA dehydrogenase family member 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_149725</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759988.1">
        <property type="nucleotide sequence ID" value="XM_016905731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QFA8"/>
    <dbReference type="STRING" id="692275.N1QFA8"/>
    <dbReference type="GeneID" id="27902868"/>
    <dbReference type="eggNOG" id="KOG1469">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_1_2_1"/>
    <dbReference type="OMA" id="WNMFLSK"/>
    <dbReference type="OrthoDB" id="434771at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000002">
        <property type="entry name" value="Acyl-CoA dehydrogenase fadE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF32">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE NM DOMAIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="9">
        <location>
            <begin position="41"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="8">
        <location>
            <begin position="168"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="7">
        <location>
            <begin position="282"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF11867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="479" mass="53050" checksum="9B9E04D87011584D" modified="2013-06-26" version="1">MSVPYKIEASEELLVNGGGGGNGRASDRIPYMARPFVSDRAKKTLDLVEKFVEEECIPADTVYQQQVGNGIERFDAHPTVIEDLKKRARELGLWNLFLPKNHFKEGAGFSNLEYGLMAEYLGKSFIASEAVNCSAPDTGNMEVFAKYGTPAQKARWLQPLLDGKIRSAFLMTEPDVASSDATNIELNMRKEGNEWVLNGSKWWSSGAGDKRCEVFIVMGKSDPNNASVYKQQSVIIVPFDAPGITIQRMLGVFGFDDAPHGHGHITFENVRVPDENIVLGPGRGFEVIQGRLGPGRIHHAMRSIGAAEKALEYMIARMNDPRKTPFGKQLHEHGVMLSRVADSRVKIDAARLQVCEAAIKIDTKDAKFALKEIAEAKILVPKILLEVLDDAIQAYGGAGVSQDTPLANMWAHGRTMRIVDGPDEVHMLQMGRNENKRGKACLAKIEWQKKKAAEMCKAYGMEKKDILQLDRKVAKQSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFC6</accession>
    <name>N1QFC6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_165133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758553.1">
        <property type="nucleotide sequence ID" value="XM_016908155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QFC6"/>
    <dbReference type="STRING" id="692275.N1QFC6"/>
    <dbReference type="GeneID" id="27905292"/>
    <dbReference type="eggNOG" id="ENOG502SUQR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018631_0_0_1"/>
    <dbReference type="OMA" id="IDSYESW"/>
    <dbReference type="OrthoDB" id="1259151at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="19"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF10432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="619" mass="68497" checksum="0CE84805B29A3071" modified="2013-06-26" version="1">MTWKSAVAPYLRVVMGNRYATFTDLPPELWDHIATYLPTASAVSALSRTNKSLYAFVEKDAWKSFARTHFPTLCAPDVPLSKHAARTLTSLSKAWDRRAFIATYVEPSHDITVFPGSKKATTWESPHGQTIGFTPLIDVYEDIEENWQHRTETLAFSAGAQICIRHTTRGGGGGSDVKWATYRPLAAREGQDDITTMHLLRPDDSLGDQRQHVITGTARGDLRLLGMPLDDPYDQDVRTTYFATQGMPVRSSSLLQEQSQPTLLATNLGDSRIALYNVDSEQSKICASSQFDLKPILRPDGNPSPNHRAWSTNFLSRTSLAIGAGPSEKPIHVYPITESGLSREGVRKLGLQNDPDGLDGKRSTSNVYTMVPLCADNGASGSGNVFLSGAYDGVVRLHDLRSNRDVEQAYVDPADDSAVYTILPRGQEKMLVGSSRHNLCKVFDLRLGARCYNYLDITQPRPGGSSAESADGDYNIFLRSSSPAFTVRGSRWNRNDHARALESSVYSLASPSAHSPYIYAGVESAIMSLSFTELLDRHPDPAYFQPWPANKSQNGNDHGADGKLVLNLAMYDQDSNMNLKVQRGYWETWRAAAPKGEFGVREQQIRLDERWRGPNSFGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFJ1</accession>
    <name>N1QFJ1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GYF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_149854</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760194.1">
        <property type="nucleotide sequence ID" value="XM_016905814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QFJ1"/>
    <dbReference type="STRING" id="692275.N1QFJ1"/>
    <dbReference type="GeneID" id="27902951"/>
    <dbReference type="eggNOG" id="KOG2950">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024456_1_0_1"/>
    <dbReference type="OMA" id="GENTNFY"/>
    <dbReference type="OrthoDB" id="331341at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039905">
        <property type="entry name" value="CD2BP2/Lin1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003169">
        <property type="entry name" value="GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035445">
        <property type="entry name" value="GYF-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13138:SF3">
        <property type="entry name" value="CD2 ANTIGEN CYTOPLASMIC TAIL-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13138">
        <property type="entry name" value="PROTEIN LIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02213">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55277">
        <property type="entry name" value="GYF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50829">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GYF" evidence="2">
        <location>
            <begin position="409"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF12073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="468" mass="52377" checksum="35B26AA9AFDDA807" modified="2013-06-26" version="1">MSSASRPKREAEEYARSQAGNSKKPRFDYRNPSTLAADAPEEDLILDADVIGKSGTNTKRNAVNIDGYESDSDNDNFDTRAREKARKKDSEAKSKDEEDDDMFADLEEDMQADGDEDEDLSREGKKKGKDVRFLEQDEIEGQVMNSEAGGKVSADILLGGKGKNRIADEDSDSSGDEEERDQLPDEMDDEDAAELGAGSKKKHAPRLDAYNLKNEEEEGRFDESGNFVRKAQDPDAVNDNWLEGLSKKDMKRAREAEEKRADERRKRAMEDDAILTSDVLSKLISQLDTGETPLEALARLNKGKTTEKKVPKWKQKKMQKKSDGMELDEPAANGNSQTDPKEEARKKAVDAITAAADALYSRGQHDIYQEERELLMRQYRRETGEDWKRSPADSETGATNSHDGGSPSSDTWEYRWSDARDGGDSHGPYDGPTMKAWHQAGYFGEDVEFRKVSSSSAAAEWRRSLDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFP7</accession>
    <name>N1QFP7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPN-loop GTPase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_91933</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757454.1">
        <property type="nucleotide sequence ID" value="XM_016910572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QFP7"/>
    <dbReference type="STRING" id="692275.N1QFP7"/>
    <dbReference type="GeneID" id="27907709"/>
    <dbReference type="eggNOG" id="KOG1533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037460_0_2_1"/>
    <dbReference type="OMA" id="ATHNYFL"/>
    <dbReference type="OrthoDB" id="5839at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034087">
        <property type="term" value="P:establishment of mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000338">
        <property type="entry name" value="GPN-loop GTPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF3">
        <property type="entry name" value="GPN-LOOP GTPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="326"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="377"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF09333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="388" mass="43050" checksum="DEAB578B11358BF1" modified="2013-06-26" version="1">MRTILMPIGPPGAGKSTLCNGLQQFMRAVARPCSVGNLDPANENIPYDASFDVRDLVDVNDVMEREELGPNGGVLWAMEEIETNVEWLEQSLAQCGMDLTIILDTPGQPELSTHHPSLPNILHRLEQQGYRIVVIQLVDSVVLTRPSLYLSSLLLCLRAPLHLPYPVVNVLTKMDNLKAVGGADLPFNLDFYTEIQDLHHLLPALSREQTASAGGASGKWDALNEALISLIEDYGLMGFETMAVEDRQSMATLLRAIDRASGYVFAGARGTDESGRTLDNEASIWAQVMSENYGRMDVRDVQERWIERKDEYDELEKKQWEEEARLAGALPEQPAASVKRPTKGDSISTDGNDPEDDLLAEQEKWQEQLAEAPAAVRHSKVIRKSTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFS0</accession>
    <name>N1QFS0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_126432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760218.1">
        <property type="nucleotide sequence ID" value="XM_016902068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QFS0"/>
    <dbReference type="GeneID" id="27899205"/>
    <dbReference type="HOGENOM" id="CLU_1571621_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF12097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="170" mass="18824" checksum="0EF34E7982B76FA8" modified="2013-06-26" version="1">MVRTAVMIESLMYEEARKEHSGAERGIGKLVASNEVFRIVSPDLVCNHSRLPPAGCARSRQMSEIGCASVPYSRVVPLLGLKWRVALPRDLLHSAIGLLKGNGSENLLPELLFRQALSASLHRILVRDCQWCCAPWIWTARAAWECLGLGLVLLHNVVCGVIAALRMRMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1QG96</accession>
    <name>N1QG96_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">YCII-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_109109</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760474.1">
        <property type="nucleotide sequence ID" value="XM_016900766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QG96"/>
    <dbReference type="GeneID" id="27897903"/>
    <dbReference type="eggNOG" id="ENOG502S8X0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110355_2_0_1"/>
    <dbReference type="OrthoDB" id="5519740at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1060">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051807">
        <property type="entry name" value="Sec-metab_biosynth-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33606">
        <property type="entry name" value="PROTEIN YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33606:SF3">
        <property type="entry name" value="PROTEIN YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF12353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="153" mass="17473" checksum="7D117FF3CAE679C5" modified="2013-06-26" version="1">MMNSQLCRSALTISRGIHSKGAASILQRSLHASSSLSDRNPTKHEWLVWLPDHEGALQRRLQHRPRHLSELSNYPSDFLLWGGPYLRKPVVSSSSTNSIQEPLDMSGSVLLAWANSPEEVKDVLQKDIFTKEKVWNWEEIRILPFKSTVRKAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGC2</accession>
    <name>N1QGC2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rad21_Rec8_N-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_55333</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764352.1">
        <property type="nucleotide sequence ID" value="XM_016909355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGC2"/>
    <dbReference type="STRING" id="692275.N1QGC2"/>
    <dbReference type="GeneID" id="27906492"/>
    <dbReference type="eggNOG" id="KOG1213">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025342_0_0_1"/>
    <dbReference type="OMA" id="QQCHYVL"/>
    <dbReference type="OrthoDB" id="5427633at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030892">
        <property type="term" value="C:mitotic cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21789">
        <property type="entry name" value="Rad21_Rec8_M_SpRec8p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039781">
        <property type="entry name" value="Rad21/Rec8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006909">
        <property type="entry name" value="Rad21/Rec8_C_eu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006910">
        <property type="entry name" value="Rad21_Rec8_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585:SF70">
        <property type="entry name" value="RAD21_REC8 N TERMINAL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G02900)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585">
        <property type="entry name" value="SCC1 / RAD21 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04824">
        <property type="entry name" value="Rad21_Rec8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04825">
        <property type="entry name" value="Rad21_Rec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad21/Rec8-like protein N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Rad21/Rec8-like protein C-terminal eukaryotic" evidence="4">
        <location>
            <begin position="593"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="188"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="398"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="401"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="447"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="462"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF16231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="645" mass="69683" checksum="234B9AF32CD73D13" modified="2013-06-26" version="1">MFYSHEVLTSRKYGVATVWLVATLGAKSSLKKVTRKAILNVDVAKACDTIVAPEAPMALRLQSNLLYGVARVYAQQCGYVLADAEAARNNLRAISRVIKQAELGPEGANKARADELMLQDDPNFAPDLDFVVADLEMLNNNLMAETQQFSQSPNGSRSLTNASQQSIGGLMIPTSNNSFGGGPVGGRDLFGVRGDSGHGTAKTPARLLDDDDLGLDLGMPVMSSGPVRQPRGPATGADRTDPARDAERIQSEHADQPMISQDEDLMPPDDAYNLASDHGQDPTQEAQDQTRHETTSETATATNMKQARKVAKKVIQMDITTSMGNRMLNEQNHNYLDRMRDENHKHQQRKLAAIAKRNAELWVLGTGTILAQGMLGPLDMFSGAALLNAFIGVNLTGGTKRSRDEAESSEDSEAKRSRNTPTHDIGRRLEMQTAGSDEFLMVDDDTIERGREAPTPLDDRQLSSLLPWNQSHGSRRPTDVNQPTSASFGGGPLLNITGRRGSRLTTASPLVGRGAVGDELDDFQLAPGSDINMTGLNDEDEFALYGVAAQVDTQTAAQTQWQKTALTGESANFLEFVQTAIDEQEDRNQGENVDFETLLPPRDNSHIVAAQAFLHVLSLGSKGALRVGQEEPFGPLVLAVDVGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGF6</accession>
    <name>N1QGF6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small COPII coat GTPase SAR1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Small COPII coat GTPase sar1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">SEPMUDRAFT_75286</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPII-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 22">Belongs to the small GTPase superfamily. SAR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764407.1">
        <property type="nucleotide sequence ID" value="XM_016910103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGF6"/>
    <dbReference type="STRING" id="692275.N1QGF6"/>
    <dbReference type="GeneID" id="27907240"/>
    <dbReference type="eggNOG" id="KOG0077">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040729_6_0_1"/>
    <dbReference type="OMA" id="GLWNKHG"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044233">
        <property type="term" value="C:mitochondria-associated endoplasmic reticulum membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007006">
        <property type="term" value="P:mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902953">
        <property type="term" value="P:positive regulation of ER to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070863">
        <property type="term" value="P:positive regulation of protein exit from endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003400">
        <property type="term" value="P:regulation of COPII vesicle coating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016050">
        <property type="term" value="P:vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00879">
        <property type="entry name" value="Sar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000161">
        <property type="entry name" value="Small COPII coat GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006687">
        <property type="entry name" value="Small_GTPase_SAR1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45684">
        <property type="entry name" value="RE74312P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51422">
        <property type="entry name" value="SAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="10 22" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 22" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="13 22" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="14 20" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 22" id="KW-0653">Protein transport</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="23" id="KW-0732">Signal</keyword>
    <keyword evidence="7 22" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110305" description="Small COPII coat GTPase SAR1" evidence="23">
        <location>
            <begin position="18"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="27"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
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        </source>
    </evidence>
    <sequence length="584" mass="64018" checksum="8D59A8E50897AF8C" modified="2013-06-26" version="1">MATSPVVPAKNIRRVSHLRTVVDDATAGDDISDDLIDVWEHAVTLYQAYEWQDAAESFLYLSRVIEHEVASTACLINSAVIFARLGDYATASHILDDAMPVGELLALTLFITAHVEIQLGEWQKAEDCFTVAVSAMEAPVHDYRRFGLTFALQRFQIQNDLNMLWQGNFEVSILPALPAECIFEAPDRYFNTPAQSSKRSSSLDSARFPALSEGGSSPPHSPASPIIRSIKYSQDALTWHGEEYDEEVLPVQSSETKYAISLPTEDAVSPVPYRKPSAIKVLGSLRRKLSTRTSTSSPAKPVDTKTTQKALLPRDPRRQDESINELAGFITDLPRTDQMAPRGIESECGNVDELLDFFRLGPEPQPIAMEQRYAPGSASSSLYSCDQSADSIRSSHLAWESTSRPPSPPYRYRPDELGLYLTQGPEAGLPSSSPPPLERELEVTSYLPHTTSQQPHDDSTNENLHSPEADLSNKPSWSSAAEAPSLPSSQSNNNNNNNNNIPPPTNPTAIEEPQIPSRKSSLLRTKFSLHRPSSSSRASRRSSKKPAAAAAVPSPPTPSVPTNKKSPNKTIGQFTKAVLEFGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1QI59</accession>
    <name>N1QI59_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">6-methylsalicylate decarboxylase</fullName>
            <ecNumber evidence="7">4.1.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_150819</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>6-methylsalicylate + H(+) = 3-methylphenol + CO2</text>
            <dbReference type="Rhea" id="RHEA:23112"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17231"/>
            <dbReference type="ChEBI" id="CHEBI:36658"/>
            <dbReference type="EC" id="4.1.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:23113"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. ACMSD family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.52" evidence="7"/>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758974.1">
        <property type="nucleotide sequence ID" value="XM_016906417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QI59"/>
    <dbReference type="STRING" id="692275.N1QI59"/>
    <dbReference type="GeneID" id="27903554"/>
    <dbReference type="eggNOG" id="ENOG502S3X1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039329_2_0_1"/>
    <dbReference type="OMA" id="GFFMDTT"/>
    <dbReference type="OrthoDB" id="2832284at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047596">
        <property type="term" value="F:6-methylsalicylate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF29">
        <property type="entry name" value="AMIDOHYDROLASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="9">
        <location>
            <begin position="43"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF10853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="304" mass="33328" checksum="0663D27565DF88B5" modified="2013-06-26" version="1">MNNLSISKSYLSISSPGTHLVPGNDTLARSLTRDCNIYASNLKKSHPNRFGYFAALPLPDISGSLQEISQAIEEGCDGFVLMTNSHGKYLGDEELNPVFEELNRRKCLVFIHPTTPQCPCSSSSSSSSPEGIAAKGGGEVPVKATPFAGRMPNPMLEFFFDTARVVTNLFMSGTIQRCPDLKIILPHLGGAAPSLLSRWTGFSQLVPGPWEGMEEAKVVEVFRKQIWFDMAGFVFPSQIRGLMDGVGVPHTRLLYGSDFPFTQSDGVELLLGQMEKGVKELFNEEEIEDLYTRNAQRLLSSGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1QI70</accession>
    <name>N1QI70_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">H/ACA ribonucleoprotein complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Nucleolar protein family A member 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_32937</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Common component of the spliceosome and rRNA processing machinery.</text>
    </comment>
    <comment type="function">
        <text evidence="3">Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765067.1">
        <property type="nucleotide sequence ID" value="XM_016908520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QI70"/>
    <dbReference type="STRING" id="692275.N1QI70"/>
    <dbReference type="GeneID" id="27905657"/>
    <dbReference type="eggNOG" id="KOG3167">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084513_1_1_1"/>
    <dbReference type="OMA" id="EDNYEAR"/>
    <dbReference type="OrthoDB" id="6921389at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002415">
        <property type="entry name" value="H/ACA_rnp_Nhp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00883">
        <property type="entry name" value="NUCLEARHMG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="5">
        <location>
            <begin position="95"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF16946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="181" mass="18887" checksum="69376529E1355969" modified="2013-06-26" version="1">MDIDNTEVSVAAPAEEESGEKKGVTTASEVGIAALVPFANPLASEKDQKKVLKSVKKAAKSKAIKRGVKECVKSIRKSPAATPSSLNPATLPPGIVILAADISPMDVISHIPVLCEDHGIPYIYVPSRAELGSAGSTKRPTSVVMITPTPGKGAADSAQEWKESFAELNTLARKLGSEVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJ27</accession>
    <name>N1QJ27_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Sterol-4-alpha-carboxylate 3-dehydrogenase ERG26, decarboxylating</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15 16">C-3 Sterol dehydrogenase ERG26</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13 14">C-4 decarboxylase ERG26</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Sterol-4-alpha-carboxylate 3-dehydrogenase erg26, decarboxylating</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SEPMUDRAFT_146281</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">SO2202</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="10">Heterotetramer of ERG25, ERG26, ERG27 and ERG28. ERG28 acts as a scaffold to tether ERG27 and other 4,4-demethylation-related enzymes, forming a demethylation enzyme complex, in the endoplasmic reticulum.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 3-beta-HSD family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765301.1">
        <property type="nucleotide sequence ID" value="XM_016903549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJ27"/>
    <dbReference type="STRING" id="692275.N1QJ27"/>
    <dbReference type="GeneID" id="27900686"/>
    <dbReference type="eggNOG" id="KOG1430">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_6_8_1"/>
    <dbReference type="OMA" id="STAHWFD"/>
    <dbReference type="OrthoDB" id="10058185at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000252">
        <property type="term" value="F:3-beta-hydroxysteroid dehydrogenase [NAD(P)+]/C4-decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000346">
        <property type="entry name" value="C-3 sterol dehydrogenase/C-4 decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050177">
        <property type="entry name" value="Lipid_A_modif_metabolic_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245">
        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245:SF51">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0752">Steroid biosynthesis</keyword>
    <feature type="domain" description="Ketoreductase" evidence="17">
        <location>
            <begin position="13"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00067470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00081267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00082106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMF17180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="385" mass="42586" checksum="190C5F75C8AD0CA0" modified="2013-06-26" version="1">MAGSNAPKMRSLGHVLVTGGAGFLGNHIVKMLAERNACDRITVLDLRPPTAPIASVDYQQGDLTDYEQMRPLFDAGHFDAVIHTASPVMTASKNREVMRKVNVEGTRVLLRAAQETGVRAFVYTSSASVIHDTQSDLVYADETYPLIMGKQQPEYYTTTKAEAELLVLAANRSPQYPHLLTAAMRPSGIFGEGDVQVLPPGLSAYYKGQTKVQIGSNENLFDFTEVTNVAHAHHLATAALLATADRDAQGLAPPLDHERVDGEAFFITNDAPVYFFDFARMCWAAAGDTTRPEQVWILSKDVGLFLATLMEWIFFLFRLGKPNLTRQQVRYTCMTRYYNIEKAKKRLGYAPLVGLQEGIRRGVADALYRGVVVGQPQELKGKKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJF6</accession>
    <name>N1QJF6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Secretory pathway Sec39</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_146382</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765451.1">
        <property type="nucleotide sequence ID" value="XM_016903618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJF6"/>
    <dbReference type="GeneID" id="27900755"/>
    <dbReference type="eggNOG" id="ENOG502R87S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006056_0_0_1"/>
    <dbReference type="OMA" id="GMKRAYD"/>
    <dbReference type="OrthoDB" id="3434013at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013244">
        <property type="entry name" value="Sec39_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40787:SF3">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40787">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08314">
        <property type="entry name" value="Sec39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Sec39" evidence="6">
        <location>
            <begin position="13"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="714"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="726"/>
            <end position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF17330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="957" mass="106695" checksum="7D6E3BB0E7E73D7B" modified="2013-06-26" version="1">MDPCQSLTAAQCVLLAVHFASESNIEALHSFTPARTDALDRELVLRIVLTFVPESLDPRRYTRYVEEVASQLYLDHEDIDVDVAPVRDLSDDEAQKRVRALCMLSIDHLPSPYAPQDLLTRFVYHRAHRIDQETGLLHLTRALVEPFLPRNDFIRTWYIGACVPLLRLPEYYPEDDSLAISLSDFEQLHGRQGVDMLLSKSGRNTVARDIKELVGPWQYGHTTRKHRQLNYGQHEKNRAIRNGDTPSDDATEAMSKISLDGIKADDQATGHCWEHVFGWLVTHAALDLGLVARAIDDWDGPRDIDLGGVERQGISYMDEELEKKLELQYAQAAFASCYVAEADTEATVQEAHSILARLAELLDFIPPPDLATSVDALPKIERHTTKLDDDSHTVADLLPDALLKQEHPLTTPRIETFMLLQMMVYSAYQFSGLQHPLSLVNVAKLHFYATRDEQLTVLRKILRGLSRSGASKNEAQWLADRAKLVWLWNWGIEADAAGVLNKISQADFEEEMLKVFTETSCFGIIEKLYLSTNASTALPRARTEAVILSKALEIYDSATNGNRQRGAMKKANDIITTFRPYFTDSIKFRQATALIAATHALSFYALTLQHGVPFQPVTIRVTPDPVGLINTVLEQNPRSYTKLDDLIGIARNLVASGLTNEESGPEAEYSDAENLVRMQKDAERRVTFMAIEAALREEDFETAYSTVVNRLTPSGADIEAPTSAKPPHKRQRSGRAKSSLEDDDISWRAAFLAGRYRPTTSASPTVRRLEQRTELLSLALLLAPTSALTEILAAWRRCEEEMISLQLSQQEAEREFDDRADKRLSASSLPGTFTVSHEQPELILNQKRREMGRMGAASGRANDETPLSMFDLTRNAAKAFSKNAFPLGGDVSAARTSAEHNRSFEQSNVGLPSDSERVRKRDMVANAVSGGIVSGLGWVLGATPASASSHDDHEQPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-12-14" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJM4</accession>
    <name>N1QJM4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_119268</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758860.1">
        <property type="nucleotide sequence ID" value="XM_016901494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJM4"/>
    <dbReference type="GeneID" id="27898631"/>
    <dbReference type="HOGENOM" id="CLU_1171251_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF10739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="237" mass="26024" checksum="45455AAEFCE31564" modified="2013-06-26" version="1">MKRARDYVPVPGRDGRVVLVSTSIRISYKSIKKEQVSLDRRRFEEFWPQYAASSGSPDNITSRSPAGPSLTETVQTYLLVLRMTTVLKARAKIPVHEAAGDTPSLQPVSELTSRSSGAACVECGVETIPLCKHAAADSGPESSPVKTSHELKMYAEITKHDTLPIAAIRSEDRGSQHCKQAQVCFAEQSTSLVVSSRLHMSLQRFQWAERQRNASHVFASFSLANIPGTFGFVELCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJP4</accession>
    <name>N1QJP4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial Rho GTPase</fullName>
            <ecNumber evidence="15">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">SEPMUDRAFT_77681</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 15">Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Mitochondrion outer membrane</location>
            <topology evidence="2 15">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the mitochondrial Rho GTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="15"/>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765546.1">
        <property type="nucleotide sequence ID" value="XM_016910169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJP4"/>
    <dbReference type="STRING" id="692275.N1QJP4"/>
    <dbReference type="GeneID" id="27907306"/>
    <dbReference type="eggNOG" id="KOG1707">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014255_3_0_1"/>
    <dbReference type="OMA" id="HETTWGI"/>
    <dbReference type="OrthoDB" id="10020961at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015886">
        <property type="term" value="P:heme transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055091">
        <property type="term" value="P:phospholipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010821">
        <property type="term" value="P:regulation of mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01892">
        <property type="entry name" value="Miro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000127">
        <property type="entry name" value="Mitochondrial Rho GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000185">
        <property type="entry name" value="Mitochondrial Rho GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000553">
        <property type="entry name" value="Mitochondrial Rho GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000572">
        <property type="entry name" value="Mitochondrial Rho GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013566">
        <property type="entry name" value="EF_hand_assoc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013567">
        <property type="entry name" value="EF_hand_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021181">
        <property type="entry name" value="Miro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052266">
        <property type="entry name" value="Miro-EF-hand_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020860">
        <property type="entry name" value="MIRO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46819">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46819:SF1">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08355">
        <property type="entry name" value="EF_assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08356">
        <property type="entry name" value="EF_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037488">
        <property type="entry name" value="Mt_Rho_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51423">
        <property type="entry name" value="MIRO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="13 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 15 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 15" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="7 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="606"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="Miro" evidence="18">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="183"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Miro" evidence="18">
        <location>
            <begin position="423"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR037488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EMF17425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="630" mass="70483" checksum="6BF3C706E930BFEA" modified="2013-06-26" version="1">MATVWICIVGDKATGKSSLLTSFVKDAFITTRIQAVLPPITLPPTLGTPDNVSTTIVDTSSLPQDRDELKKALRKCNVILLVYSDHYSYERVALFWMPYFRSLGVNVPVVLCSNKSDLNPGVSTAIEDEMLPVMTEFKEIDACIRTSAREHHNINEVFFLCQKAVTHPIAPIYDSKENALKPAAIDALKRVFYLCDKDQDGFLNDKEIQDFQRKCFDKSLSNEDLANIKRSIQRSKNEASHDQQENNAGRGIDVSGFIHLNKMFAQKGRHETVWIILRKFQYSDSLSLSDTFLHPKFDVPAHASAELSPLGYRFFVDLFLLHDKDNDGGLSNAELAALFAPTPGIPALWVDSGFPCSTVRNEAGYVTLQGWLAQWSMTTFEDPRITLEYLAYLGFEIDGKGTITALKVTKPRKRRQRPGRVERNVFLCYIIGAAQSGKSALLNAFLARPFNATYHPTIKPQTAVNSVELQGGKQCYLILEELGELEPAILDNQAKLDACDLLCYTYDSSDPNSFAHITHLRKRYPALLSSIPSVYVALKADQDRAVQRTEIQPDVFCEQLKMAKPLHVSAKWTSISDFFVHLAECATYPSQALPKSEDDSVDRTTLYVGLAATIGVATAFAWVWKRNVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJY9</accession>
    <name>N1QJY9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_156965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760246.1">
        <property type="nucleotide sequence ID" value="XM_016907708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJY9"/>
    <dbReference type="GeneID" id="27904845"/>
    <dbReference type="eggNOG" id="ENOG502R9G1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_860978_0_0_1"/>
    <dbReference type="OrthoDB" id="62952at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF1">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="9"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF12125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="323" mass="36943" checksum="003D012694504B42" modified="2013-06-26" version="1">MASSASLLNLPTEVRLIIWSYLFVDEWVYISPCNSTPEPQKPLHHQEHLPAIMRTCYELQQETAPVYYSSVHVHFDVLPGVRPMCLVHWLDDIGEAYARLVKNFQIRWNCYVDVSLELNPSGSSRNSSIYRRMRAEDDDEKISGYYQQHHHHHQRLAEISLQNKKSNNNTIIEPPTAVHIAPTYTLRIQAVIPPPFFFQFFFSPKTTTSTTSTTRPKVSAPGPLHHPAQFWKLHGTADFCRTLTHNLARELSSERSHSHSHSPRYTGDINTAIATARVAPSLPSPPPPPSLSSLLEERMEDFIMGFVNVVDDHAQALRWLGYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKI4</accession>
    <name>N1QKI4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.205</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">2'-O-ribose RNA methyltransferase TRM7 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_78205</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>cytidine(32)/guanosine(34) in tRNA + 2 S-adenosyl-L-methionine = 2'-O-methylcytidine(32)/2'-O-methylguanosine(34) in tRNA + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42396"/>
            <dbReference type="Rhea" id="RHEA-COMP:10246"/>
            <dbReference type="Rhea" id="RHEA-COMP:10247"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74445"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.205"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.205" evidence="7"/>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765806.1">
        <property type="nucleotide sequence ID" value="XM_016910188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QKI4"/>
    <dbReference type="STRING" id="692275.N1QKI4"/>
    <dbReference type="GeneID" id="27907325"/>
    <dbReference type="eggNOG" id="KOG1099">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009422_1_0_1"/>
    <dbReference type="OMA" id="FIVCLNF"/>
    <dbReference type="OrthoDB" id="289250at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106339">
        <property type="term" value="F:tRNA (cytidine(32)-2'-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106340">
        <property type="term" value="F:tRNA (guanosine(34)-2'-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106050">
        <property type="term" value="F:tRNA 2'-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002130">
        <property type="term" value="P:wobble position ribose methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000176">
        <property type="entry name" value="tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03162">
        <property type="entry name" value="RNA_methyltr_E_TRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028590">
        <property type="entry name" value="RNA_methyltr_E_TRM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF12">
        <property type="entry name" value="TRNA (CYTIDINE(32)_GUANOSINE(34)-2'-O)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="9">
        <location>
            <begin position="21"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="266"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF17685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="377" mass="41308" checksum="4CEC3B369D8F1487" modified="2013-06-26" version="1">MGKSSKDKRDAYYRLAKEQGWRARSAFKLLQLDEEFDLFSGVSRVVDLCAAPGSWSQVLSRILIKGERIGRASWEDKRHHYLLQQRNGNQAPDEAPDVAAEPDRSPRSDVKIVAIDLQPMSPLEGITCLKADITHPSTIPLLLKALDPDYDPASSSSAATEASHPVDLVISDGAPDVTGLHDLDIYVQSQLLWAALNLALCVLKPGGRFVAKIFRAKDVDVLYAQLKTVFESVNVAKPRSSRASSVEAFIVCTNFRPPPGFRASLDDPLGVSSGHSLQPQEDESLQSDETCRTTRTLRADGITEINIDTNHQSHRWIAPFLACGDLSAFDADASHKLPEGHVSLDPVQPPTAPPYRKALEERKKMGGAYGKTKLGHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1QLB6</accession>
    <name>N1QLB6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_149803</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760117.1">
        <property type="nucleotide sequence ID" value="XM_016905778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QLB6"/>
    <dbReference type="STRING" id="692275.N1QLB6"/>
    <dbReference type="GeneID" id="27902915"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020492_1_0_1"/>
    <dbReference type="OMA" id="LHHNDLV"/>
    <dbReference type="OrthoDB" id="10029320at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11051">
        <property type="entry name" value="CYP59-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF107">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="480"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF11996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="565" mass="64802" checksum="246C2397805F5C4B" modified="2013-06-26" version="1">MYELLESNLVQAAFGAILVGYVLKFLVKGYQVRRQRRSLPGPPATSWLWGDLKTMGEVAMSLPRRVHPHVFPTFIRKKFNYTRSFMFLDVWPVNSPMIAIMDPAICQYFTVEHTTEKADSLPHFLYALAGKDDMVSANGNVWKKWRTMFNPGFSTQHLLTLVPGIVDDALVYVEKLTEHAHKQDLFRLEEDTTRLTVDVIGKVVLDVRFNMQRGEDECINALREQVHYLPNETLNPFAMWHPYGMYKRWKNDRIMKRYIGKMLDERFASKEVVNEKNQRKRTIIDLALDSYISSGGDVEEKLDSSATTNLPQVMDAEFREGAITQIRVCLFAGHDTTSSTICYAYHLLQKHPQCLQRIREEHEAILGPVSQAAERIKQDPKILHKLEYTLCVIKEALRLFPAASAPRKGKKGLFLTDPQTGEKFSTEGWMIWLVHYGLGHSEDVWGPTAKEFRPERFLPENASGIPEGAFRSFEMGKRDCLGQNLALLESRIILGLTCRQFEFDVALDEKSLKDIGRDGSFYAKDHSFRQGKQDVDGEELYQVLVGAAKPREGMPCRARMVEWKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>N1QLC6</accession>
    <name>N1QLC6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_145681</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764554.1">
        <property type="nucleotide sequence ID" value="XM_016903197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QLC6"/>
    <dbReference type="STRING" id="692275.N1QLC6"/>
    <dbReference type="GeneID" id="27900334"/>
    <dbReference type="HOGENOM" id="CLU_809336_0_0_1"/>
    <dbReference type="OMA" id="KSMSTSM"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110956" evidence="3">
        <location>
            <begin position="17"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF16433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="343" mass="34619" checksum="008A1B86C3365C95" modified="2013-06-26" version="1">MQYHFAAAALVAGAMALPGYAPPPPQGYGGPPESSTTPVSPVMPTKSSSMSMSTTMPTTMTTTMATTMSKSMSSSMSTSMSSSMPTMSKSSSMSMSTSMPTKSMSTSMSKSMSSSMSKSMSTSMPTMSKSMSTSASTPCPSTPVKSTITITSTMPVHPTPTGPTPNSPVHPPTYGPPPGSPVTPPKESHPPTYGPPPGTPGTPPSSPVTPPKESHPPTYGPPGTPPSSPVTPPKEGPPGYGPPNSPVSPPAYPPTTPGKPETPPSSPEQPPKPYYPTPSTPSEHPVYPTGTAPCPPGAYPTGSGVPPTMPMPSKPITPYVGAANALNAAGVLAGFGAVLAFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1QLW0</accession>
    <name>N1QLW0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_146306</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765328.1">
        <property type="nucleotide sequence ID" value="XM_016903566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QLW0"/>
    <dbReference type="STRING" id="692275.N1QLW0"/>
    <dbReference type="GeneID" id="27900703"/>
    <dbReference type="eggNOG" id="ENOG502S40Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_802080_0_0_1"/>
    <dbReference type="OMA" id="ECKRETV"/>
    <dbReference type="OrthoDB" id="5419542at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="91"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="234"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF17207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="346" mass="39465" checksum="DE95FA638B7A8565" modified="2013-06-26" version="1">MAQEESMVSPKALPKLRTTTDQQGASARPRADTAVPNDHEKAHLHRRLQSTSLRNRAFTGAKDYRHAAKETVQSALELKPPISFDSLLRREKKGHDSGRHGSSRHISRRQQETQQRNVDEWAIQQVELARRPQVKSEDVEKAKRDNVKREKGLRTSLSAVEDVAMSSTRQLDDTYYAILERASLLRNTVASLQQLTEESRRMHSGFEEETKQLEQSTISRFDAFANFDPQEVTINSLVDQLKHSKQNADELNDRLEAARHRVEAYEQREKKKQKTSRQRWSAVWVTLAGLAVLIVALILAKSRAGQVQHAARVVEVVDELGHEMSGMLLPKPKTEDDTLRQLFDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1QM06</accession>
    <name>N1QM06_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD_binding_7-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_146014</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="4">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA photolyase class-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765004.1">
        <property type="nucleotide sequence ID" value="XM_016903400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QM06"/>
    <dbReference type="STRING" id="692275.N1QM06"/>
    <dbReference type="GeneID" id="27900537"/>
    <dbReference type="eggNOG" id="KOG0133">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010348_3_3_1"/>
    <dbReference type="OMA" id="GNWNYTA"/>
    <dbReference type="OrthoDB" id="435881at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003904">
        <property type="term" value="F:deoxyribodipyrimidine photo-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043153">
        <property type="term" value="P:entrainment of circadian clock by photoperiod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.579.10">
        <property type="entry name" value="DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="CRYPTOCHROME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455:SF9">
        <property type="entry name" value="CRYPTOCHROME CIRCADIAN CLOCK 5 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="Cryptochrome/photolyase FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="Cryptochrome/photolyase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="2 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="6">
        <location>
            <begin position="4"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="576"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="624"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="322"/>
            <end position="329"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF16883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="637" mass="72042" checksum="D548235F0196F231" modified="2013-06-26" version="1">MSKPRILYWFRTDLRLHDSPALKAALDLQPEVLYPIWCWDSHYVYRARVGVNRWQFLIDCQNDVSKSITKLNKKSKLFVLREPAVTLLPKLFKKWKITHLVFEKDTDAYARERDEQVVRVAGEAGVEVIVKVGRTLYDPDALVKANGGKPTMSMTQLQHAGAKIGDIEQPVETPTSLPDPGDMTLDIEQEEPEAVPDINAKHREKDAVTFSSGIAGPKGDFSPPTLEELGMAPATSPHKGGETVILEALEKILQDEEYTSTFEKPKTSPAAFEPQSTFLTSPYLHFGALSCRYFYHRVAEIVEKRKKEKKPTSAPPESLTGQLLFRDMYFAAQAHGGWQYGQTLGNAHCRFIPWHLPSKVDMDTKRITAEHEIDDEEKEEWFQRWSQGTTGFPWIDAHMRALRSTGWIHHLARHSVACFLTRGGCYISWERGAEVFEELLIDHEAACNIGNWQWLSCTAFFSQFFRCYSPIAFGKKWDANGLYIRRWIPELKDLPNKYIYEPHKAPVQDQKKAGVRVDGDGSKAEQDGLKLYPKPMFDFNERRDICISAMKQAYHVGLYGDDPKVLDGSWKELFDDNAEGPTAGAKGGPAGLEAPIRSSDDNQGHAADSSGTSRASPRGHKREHSQTKLDFGKKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>N1QM24</accession>
    <name>N1QM24_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation factor G, mitochondrial</fullName>
            <shortName evidence="10">EF-Gmt</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Elongation factor G 1, mitochondrial</fullName>
            <shortName evidence="10">mEF-G 1</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Elongation factor G1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MEF1</name>
        <name evidence="12" type="ORF">SEPMUDRAFT_121901</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764480.1">
        <property type="nucleotide sequence ID" value="XM_016901737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QM24"/>
    <dbReference type="STRING" id="692275.N1QM24"/>
    <dbReference type="GeneID" id="27898874"/>
    <dbReference type="eggNOG" id="KOG0465">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002794_4_0_1"/>
    <dbReference type="OMA" id="GQFAKVQ"/>
    <dbReference type="OrthoDB" id="198619at2759"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01886">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04097">
        <property type="entry name" value="mtEFG1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04091">
        <property type="entry name" value="mtEFG1_II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000001">
        <property type="entry name" value="Elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000022">
        <property type="entry name" value="Elongation factor G, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000015">
        <property type="entry name" value="Elongation factor G, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000558">
        <property type="entry name" value="Elongation factor G, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00054_B">
        <property type="entry name" value="EF_G_EF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047872">
        <property type="entry name" value="EFG_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43636">
        <property type="entry name" value="ELONGATION FACTOR G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43636:SF2">
        <property type="entry name" value="ELONGATION FACTOR G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10 12" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="95"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="104"/>
            <end position="111"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="185"/>
            <end position="189"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="239"/>
            <end position="242"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF16359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="810" mass="89520" checksum="0A5A720E3F1FDA10" modified="2013-06-26" version="1">MRVQALTRLSLRNTALRSPSTRTFTSASTCYPLRQLSLSGQKHDRIPGARWTQPRRWASATAAASVLETAMHDPASLSQSAIVENLDPKEAARLDKVRNIGIAAHIDSGKTTATERVLFYTGRIKDIHEVRGRDAVGAKMDSMDLEREKGITIQSAATFCDWVKKVPDPVTGELKEEKFHINLIDTPGHIDFTIEVERALRVLDGAVMILCAVSGVQSQTVTVDRQMKRYNVPRLSFVNKMDRAGANPWKAVEGINQKLRIPAAAIQIPIGAEDQFKGVVDLIRMRAIYSEGDKGVIVREDECPADLVEFAKEKRQVMIETLADVDDVIADAVLDEREPSVDEIKAAIRRATIGLKFTPVMMGSALADKSVQPMLDAVVDYLPNPSEVENLALDRRRNEATVKLVSYNSLPFVGLAFKLEESNFGQLTYIRVYQGKLSKGQNVTNARTGQKVKIPRIVRMHSNEMEEVSEIGAGEICAVFGIDCASGDTFTDGGKLDYSMTSMFVPDPVISLYIRPKHTKDTPNFSKAISRFQREDPTFRVHVDTESGESIISGMGELHLDIYVERMRREYKVEVVTGQPQVAYRETIQNHVPFDHLLRKQTGGAGDYARVVGYLEPTEPSESGSEAGFGENKFESQIVGGTIPEKYLFACDKGFQASCVNGPLLGHRVLGTSMVINDGATHMTDSSELAFKNATQQAFRKAFLAAGPQVLEPLMKTVITAPVEFQGNIVGLLNKRNSIINDTEIGAEEFTLTADCSLNSMFGFSSQLRAATQGKGEFSMEFSHYAPAPPQLQRELIAKHEKERAEKNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1QMC4</accession>
    <name>N1QMC4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_57097</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765184.1">
        <property type="nucleotide sequence ID" value="XM_016909423.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.N1QMC4"/>
    <dbReference type="GeneID" id="27906560"/>
    <dbReference type="eggNOG" id="ENOG502QQFV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001029_0_0_1"/>
    <dbReference type="OMA" id="HSWKFFA"/>
    <dbReference type="OrthoDB" id="102511at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044840">
        <property type="entry name" value="Nup188"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041634">
        <property type="entry name" value="Nup188_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048883">
        <property type="entry name" value="Nup188_N-subdom_III"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31431:SF1">
        <property type="entry name" value="NUCLEOPORIN NUP188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31431">
        <property type="entry name" value="NUCLEOPORIN NUP188 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18378">
        <property type="entry name" value="Nup188_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21093">
        <property type="entry name" value="Nup188_N-subdom_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup188 N-terminal subdomain III" evidence="10">
        <location>
            <begin position="728"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="domain" description="Nuclear pore protein Nup188 C-terminal" evidence="9">
        <location>
            <begin position="1439"/>
            <end position="1804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF17063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1812" mass="199309" checksum="33C5C36834CC3D37" modified="2013-06-26" version="1">MSSSYFPALDQYLAGETPLISWRTAYRALCDEAAALDNSSLHAFFTDDHTVALLANALSPYAPPSARTAGEFDTKTAPIHAAQPKNGAYKLDEIKEDAKWLSRELHVEELAALRIAMIECQERPADQLMNAACNGTSVLEEVIAMPASTASNGPARPALTFADQQVRRHRLLLVYLSESNHMLRLSADLMSRCAVSKSIVREQPAAASWIDQIAAKVTDTMCPKNGRNEAEAFIAKCISKLDSVLERGDASTSWPKVFADDTKAPGYVDSLRYELTHTLRLLLAALYQYDGIPSASALLSWFALMEKHFFLQGNKHLLPLDLDVPRLLLSIVSVEMMKLQLAIGEIMQAADVDTPTLTGSHYLNDEESLRSLNLILHRVSLRGNNIAAPAILAWSIITSVIRDIALSHRDQREFRNEHGPDDTVEGLARRASRRGSRNEPLSRFEKLYFKLQSSELDGDVRDDLPRNFLLRSVDHLRVFRLIATLATVITTTYSSDAEASTALFCKEALFDLTRESLSFVQYDEEVFEAVLSLLTPAEHCPVSKQQTTVLAKKLLADYALLRPAFLDQALARFPYELSPLVRLGTLLANAQGDAQEPEGIAGILHRLRTFTLQVPAEFRSYELIDEVDDNNAMRLLEALPIITRRDAAAGVQQLLLMQDSTDAETPEQYVPAETTGNIIREKRPMVFMLNHDSSGLEYLSALLFTFTKGSQVSCAAEQATLDLYAAAEIIALFTSLLAACLDQSDGATTARELMAKFDAGLGNSHDIISIIADLFESELLAHIEQVAEDGSLPVVAAAAEFLNIIIRISPERVWSIVAKSSLLGLATGAISLVAVVNGSEVQLGQYRFLQACVEMQSLLLQDALAGLAKRNARTSEVVKTTRFSLKTKQDSLDATPARTMSVVLNAYQKVLLDAYQSFSDWKWEDLSQRCRLTVTLLKSFSDMLRSTYGLNVAKAVSRRLTFVIAPAANSIVDTCASKTGSNPMASTLRRILQETLPIADDATPVQIRQLLIEQARAVFGFLVILLRVVKHRSYRLASSILQNMPALASLLATEHAIKADLFTLFEELVSAVGAGDEDPPSILAQFDTDAAQAFLQVVTQLDRPLCELQVERNAWDFLAVVMDSRQQWFAIYLLTGRLPKSRAHRCHEEEIKGKPILAHVLSQLASIEDLQPQRAIGMLRFVAIAQQTWAWATNEVRSHTDFLTNTMSWLGSLRGPPRNPTPDASITSAREHEMAAHLCDIFAVNLHAGLEIGDRTVLKLLVTKLDFLRDRGARVDEWNKSLHRSLETNLARSFPAIDLSDFMRTSVNPAPYGRSYVYDTDIATIIFQHNRAWDGATADQGFADEFGRANANLSLLHAQATLLKSWKTLATTLCDCAEQDPSLPLELAKVVEQCLVASVEPQLDQPGMADAMHMRLELAFVLTSKLVALKTEDDAMKRLLPAAWTLVATFPADYDIATLPEELRYYRQLLQVLYLTILPHSYVAKTRADGEMHSLSPQTASILVNIVGKVIAPGFKALCSNLHGNVELALPADFALLTALLQAILAVPGINSIQTLLSDVVVGSNIIRGALSLYSWADRLSSEDTQDPIYGEIAIMFLLSLSTVRPIAEQMALEGVLAQLSSANLSSYFRTHGGKGPFDEPQRMFVIWTEGYLPLCLNLLDSVGPAIAAEIAAFLNGFPSQLDRAAHSLINETPTARNPRAGTITLGTVSEAHSLAMISLVLSSDTARGAADGINAADIPDFHYDGQSVKSLVESLMRSKRSLIDRIRPANPLEERWMTTPGVANADNILVQKIEKELSSMLTCFKGVEGVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1QMJ3</accession>
    <name>N1QMJ3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1857-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_36068</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765698.1">
        <property type="nucleotide sequence ID" value="XM_016908626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QMJ3"/>
    <dbReference type="STRING" id="692275.N1QMJ3"/>
    <dbReference type="GeneID" id="27905763"/>
    <dbReference type="eggNOG" id="ENOG502S7JX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111642_2_0_1"/>
    <dbReference type="OMA" id="FEWRHPD"/>
    <dbReference type="OrthoDB" id="2320332at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015075">
        <property type="entry name" value="AtaL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08982">
        <property type="entry name" value="AtaL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF17577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="174" mass="19829" checksum="C6F93372B9177093" modified="2013-06-26" version="1">MVTINCAYSEAINPSSGVTPILSRSQVWKGLQIKIREAQRFVPVIERCEVLEEEEKKNNGEEEEEEKWGQVTRKVWFKSSDGKSVKEVCKSYWPVKVDFHQPDGAVITNTISDGEAEGSMLMSMSYTFEWRHPDVAEGSEEHMKLMEEHRKGAKMAVSKSLEAMRKMALDGELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>N1QMZ4</accession>
    <name>N1QMZ4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_146737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765913.1">
        <property type="nucleotide sequence ID" value="XM_016903831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QMZ4"/>
    <dbReference type="STRING" id="692275.N1QMZ4"/>
    <dbReference type="GeneID" id="27900968"/>
    <dbReference type="eggNOG" id="ENOG502RGAZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1361167_0_0_1"/>
    <dbReference type="OrthoDB" id="3641288at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF17792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="201" mass="21805" checksum="E521CF3FB559CB37" modified="2013-06-26" version="1">MLLDYEIPGLSIQKGDPVDKGQWIEITMNARAAREIVPWACSRRTRRDSMALALSRMRSMSVTPSVYSAGAPEGVRTAQALKVKYDELHIMQPPLLGIQAYMIDPDGSDASSMGSSTGSDSDNDDNDPDDSQTPAPCAKISCDAGINLEFVAEATLALLPERGGDPDDDDRQIVFKAIVSFCEPAQSLRKRGTTRSVILLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2024-01-24" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1QN27</accession>
    <name>N1QN27_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_35302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765968.1">
        <property type="nucleotide sequence ID" value="XM_016908606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QN27"/>
    <dbReference type="STRING" id="692275.N1QN27"/>
    <dbReference type="GeneID" id="27905743"/>
    <dbReference type="eggNOG" id="ENOG502S1AV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1151770_0_0_1"/>
    <dbReference type="OMA" id="HLWAVVQ"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39472">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39472:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF17847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="246" mass="27941" checksum="913B6ECC1E8A06E2" modified="2013-06-26" version="1">MYTGMNGGIMPSAGHYSDMQTLMQNMESLSGWLEQNRQDWAQVQDGIARVERLQGRLAQNGQIPLLNGDPPSEPESDQPTIAQLSDSLARANLQLESMRNTYNDHVSLQRLYEETLTDTTERIRQYCFEQQNHIIALHQHYTTLLSQSRSETVEAQLTHQAWQASLQRVSENVREAMKARQEEGMPYKRRIAGLKEENRVLRKMAGWEPAVDSDDEEVVEEEARRGRVLHVSGAESGIGHGVQQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1QN76</accession>
    <name>N1QN76_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AhpC-TSA-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_58875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016766058.1">
        <property type="nucleotide sequence ID" value="XM_016909477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QN76"/>
    <dbReference type="STRING" id="692275.N1QN76"/>
    <dbReference type="GeneID" id="27906614"/>
    <dbReference type="eggNOG" id="KOG4498">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035338_1_0_1"/>
    <dbReference type="OMA" id="HTFKSIY"/>
    <dbReference type="OrthoDB" id="40334at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02970">
        <property type="entry name" value="PRX_like2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032801">
        <property type="entry name" value="PXL2A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28630:SF3">
        <property type="entry name" value="PEROXIREDOXIN-LIKE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13911">
        <property type="entry name" value="AhpC-TSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF17937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="22866" checksum="C30B5C061A248B08" modified="2013-06-26" version="1">MGASTAEDDRRRELPTEAALSEAGEIMIKDKDGKEIPLKSLYTGKPADERQLLIFIRHFFCGSCEQYIHALTQDLHPSVLSPAKINLTIIGDGEHILITDYAKRTSCPFEIYTDPSVQIYKTLGMISSLKPAPITPTYHQKTFLRNALDSTWTALTSGHPLSAGPSAQNGGEFLFQNGELKWCSRMRNTTDHTETAELKEILGLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNF6</accession>
    <name>N1QNF6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_130408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765839.1">
        <property type="nucleotide sequence ID" value="XM_016902356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNF6"/>
    <dbReference type="STRING" id="692275.N1QNF6"/>
    <dbReference type="GeneID" id="27899493"/>
    <dbReference type="eggNOG" id="KOG1337">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044629_0_0_1"/>
    <dbReference type="OMA" id="AWYRSRC"/>
    <dbReference type="OrthoDB" id="441812at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10527">
        <property type="entry name" value="SET_LSMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF76">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF17718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="515" mass="57489" checksum="662B43833D8AE52C" modified="2013-06-26" version="1">MLIKRGKAEGWLQLDTVALRAWAEASGITFTNASPSTVPGRGMGLLADSDLKAESSSPTEILSVDEDLVLSGEAVRRHAKFDKDFREVLESLGDFGRSNLLGHATPRGAILSFLLFQASVSCPDLSEPVGVHCAFTDYVKSLPCELLPTFWSPSELQLLIGTTLAPAVSAKLKSLHREYDLLCESAANTRWYKIASPHISFDDWLHVDAMFRSRALDFYGSCMIPGMDLASHAAHERTNAFYDRADGKYRLYLMKDKALRQRDEVCITYGDEKGACEMLFSYGFLDEHMDTAETLFLSLNIPDDDASRTAKLKIANCAPGFKLIDVCSSFSSDEDSATSPPEAKRSASSSGSIDWTGDFIYLLCLTHDDGLQFELAQRTDDVEPELCATFNDNELPDGAASLRRLLAQSDQWDVYRLRAIVILQQRVFEQMQVLYSSQDAMEDVPHGEATDVRDSVYEQAMKLRQLEFELLERAYEDFEKQKLELAESPAVKRYLDEMNSTPKGDAQNSPLEDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNI8</accession>
    <name>N1QNI8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_122725</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765445.1">
        <property type="nucleotide sequence ID" value="XM_016901795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNI8"/>
    <dbReference type="STRING" id="692275.N1QNI8"/>
    <dbReference type="GeneID" id="27898932"/>
    <dbReference type="eggNOG" id="KOG1587">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012999_2_0_1"/>
    <dbReference type="OMA" id="MHDRPEY"/>
    <dbReference type="OrthoDB" id="366230at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010970">
        <property type="term" value="P:transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF22">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 1 INTERMEDIATE CHAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="504"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="27"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="151"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF17324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="683" mass="74853" checksum="56077AA57C664C8D" modified="2013-06-26" version="1">MSSSSSSSMQQRKEEILAKKAKLAELKRQRELRQKDLNTTRHSLDASELVAPSPQRISSSSFKREDIESLISSLVDRPASTANTTNSHLSDDGHTSPPAAATIPRTSDGHAVPQTLSLAALTTVYEIPVESKPEYITYSKGVQTAADGWQQTSVDSAEGSDGDATSTSPTRRRRNLSPRARELHEETIRQRLRQEIEEELRALQSNDHVEPDKERFPARALAPEELSAVTSSNDFLDFVERSSKVIERALDEEYDVLADYAANARAAEDEDDEYVGRRGRRVKEVASFELQHEMGKQRMISDIDFSPKFPELICTAYTKSQSSPHTSPGLLNVWNMHLKGRPEYSLHATSDLLSCQFHPFHPSLILGGTYSGQLCLWDTRARNQRTGEPVQKTPLTGGRTGHAHPIYSLATVGTQNASSVVSVSTDGVVCAWSTDILTQPQEYLELHAPNPSAHKTDDVAPTCISFPAADPTYFLAGTEQGSIFPVHRYDRAGAKSGVDARTSYRGHEAPVTGIDFHPASGKIDLGDLFVSCGLDWSVKVWRARPPSTTSSTISGNAEIVKPLLEIQREDSVYDAKWSPTKPGIFGCVDGSGRFDIYDINVSSEVPVGGARPSHQEKDIYALKSLNKLAWEKNQGRHAAVGGLDGVTTVFEVGSELGGADTKSDAWLGIKKFVARRAKNKVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNW7</accession>
    <name>N1QNW7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Metallothionein-I transcription activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_138403</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765860.1">
        <property type="nucleotide sequence ID" value="XM_016902877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNW7"/>
    <dbReference type="STRING" id="692275.N1QNW7"/>
    <dbReference type="GeneID" id="27900014"/>
    <dbReference type="eggNOG" id="KOG3507">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_179456_0_0_1"/>
    <dbReference type="OMA" id="TRRSTCF"/>
    <dbReference type="OrthoDB" id="5585087at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006363">
        <property type="term" value="P:termination of RNA polymerase I transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.30:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerases II, IV and V subunit 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.30">
        <property type="entry name" value="RNA polymerase ii, chain L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006591">
        <property type="entry name" value="RNAP_P/RPABC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039747">
        <property type="entry name" value="RPABC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12056">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12056:SF2">
        <property type="entry name" value="GEO11084P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03604">
        <property type="entry name" value="Zn_ribbon_RPAB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00659">
        <property type="entry name" value="RPOLCX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="RNA polymerase subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF17739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="87" mass="9685" checksum="33A7B152B5D4D1F3" modified="2013-06-26" version="1">MSREQYTPPALSGQQNTTNPGANTSQGGFNITGGSTFEDTSKPVNYLCGDCDTKVILKKGDPIRCKECGYRVLYKERTNRMIQFEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNY0</accession>
    <name>N1QNY0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">SP-RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_22326</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NSE2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765925.1">
        <property type="nucleotide sequence ID" value="XM_016908352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNY0"/>
    <dbReference type="STRING" id="692275.N1QNY0"/>
    <dbReference type="GeneID" id="27905489"/>
    <dbReference type="eggNOG" id="KOG2979">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028753_1_0_1"/>
    <dbReference type="OMA" id="TWFSHLE"/>
    <dbReference type="OrthoDB" id="756301at2759"/>
    <dbReference type="UniPathway" id="UPA00886"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16651">
        <property type="entry name" value="SPL-RING_NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026846">
        <property type="entry name" value="Nse2(Mms21)"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21330">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21330:SF1">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11789">
        <property type="entry name" value="zf-Nse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SP-RING-type" evidence="12">
        <location>
            <begin position="255"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="124"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="344"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="124"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="149"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="368"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="420"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF17804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="433" mass="49151" checksum="D36A45A4E40EEB69" modified="2013-06-26" version="1" fragment="single">PEYEPPTFPLNPEAQRSIANLLRKHDVHKLEDVIVQVQSELTTTGASLYDKLYEHEDQLKRRQRKQTEATQTEKFTAFEQQVKEMREKVEGMAGRMEKEMRALVDCSVSAKAMRDAVVAAEADAKANASTQASTQHTQTQRPRRRENNNEEEEENDGGEEDEEIPWNPTDPAGASQRAPRDVFDTHVRNARDRHQAQSQYERYAETDAYVKWKKLIHDAQTGGDEDNPLPDPSEWFVEAGAPPPGTQRNNNADELDDDISLIRTKISIKCPLTLQEFKDPLSSTKCRHHFESHAILQLINASTTRPKATQCPVSGCNCLLEKGDLHRDELLIRQVRRIQRANRLREERGDDSDSDMENGAQRRGHVIDDDDDDGVNIDEMNEDNTQRAQAQQVKPEPEATGSTPQREPTQPPGGTQVIDLDSDDEDEDEDEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M3ASH0</accession>
    <name>M3ASH0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_159334</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756560.1">
        <property type="nucleotide sequence ID" value="XM_016907836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3ASH0"/>
    <dbReference type="GeneID" id="27904973"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_1_1"/>
    <dbReference type="OMA" id="CSFAVHI"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF17">
        <property type="entry name" value="HEXOSE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="445"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="24"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF08439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="543" mass="60048" checksum="213E6692B67A112D" modified="2013-05-01" version="1">MVFHWLHEARTDLSRELTLPLFTTVLYASLAGMSYGLDLNYWSGLLGMPQFQHDFGVFDVALQTWKIPASWQSVGSGTPTAGIACGALLAGYLGNRWGRIRAFWTAAGIGLVGILIQATSVRSYWQLVGGRIVNALSMGIICNIIPIYQGEVAPASLRGSFVNTYQFMLLFGGLIAVIVNWAMNERTDQWAYRLIILLQFIIPLIMTIGGFILPESPRWLISQNRNQEALAVLQYLRRGHPPSVIEKEVSLISQSVSLQKSLHQTSSYTECFRGPNLRRTLIALGVQALQPTQGNSYMTTYSIVLFQTIGIGNEYQMLIYLYIVMLFADASAFIIADKIGRRPLMFVSSVCIAASLFCVGGLTGFAPQTEGVKKGTLAAIFFWYFIDAVGWAGCVWITCAEAPTTALRERTMTIATFGGFVVNLLIQYVSPYLQDAGYAGLGGKIGFVWGSFAIVAAVWVAFFLPEMSRRSLEELDELFEKRVSVWKFRKFRTEGVGAELTALEAGVKTAEDVEMHGAKVLVGVEVRPVESETDEYGKKKLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M3AT85</accession>
    <name>M3AT85_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chaperone J-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_16621</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756850.1">
        <property type="nucleotide sequence ID" value="XM_016908210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AT85"/>
    <dbReference type="STRING" id="692275.M3AT85"/>
    <dbReference type="GeneID" id="27905347"/>
    <dbReference type="eggNOG" id="KOG0712">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017633_18_1_1"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051948">
        <property type="entry name" value="Hsp70_co-chaperone_J-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44360">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44360:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004031062" evidence="2">
        <location>
            <begin position="21"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="23"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF08729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="88" mass="10219" checksum="361103E6028F0E3B" modified="2013-05-01" version="1" fragment="single">IIIVAFFLFTVLKVDRRVQGEGNYYRMLGIPLDADQKMAKKAFRIMAKKYHPDKIAPEEAHNDTFIHLRAALSVISDPDLRHVYNRYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M3ATM0</accession>
    <name>M3ATM0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SEPMUDRAFT_151770</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the glycosyl hydrolase 16 family. CRH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756980.1">
        <property type="nucleotide sequence ID" value="XM_016907034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3ATM0"/>
    <dbReference type="STRING" id="692275.M3ATM0"/>
    <dbReference type="GeneID" id="27904171"/>
    <dbReference type="eggNOG" id="ENOG502QVQI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027506_1_1_1"/>
    <dbReference type="OMA" id="VRLGIWP"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF27">
        <property type="entry name" value="GLYCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004031515" description="chitinase" evidence="14">
        <location>
            <begin position="22"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="15">
        <location>
            <begin position="38"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMF08859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="383" mass="42145" checksum="A7E07AB0E575EBFB" modified="2013-05-01" version="1">MSRRFASIALLVATSLAQTYTDCNPNNSTCPDNPALGTTFAETYNKTQQEFDPRFWNVTAGPSLISFGDDGAALALSQKGDSVTVKSNFYIFWGQVEVIFKAATGTGIISTAITLSDNLDEIDWEIKGGNLTSSSNNFYGWGNTSQFNSEYPAMNPGPQADFHNYTVDWTQERILYYLDGNVVRTVPYAEPGHYPQTPSRIQFGAWCGGCSESQGTIDWAGGKADWDAGPFVMTVQSIRITDGTTNSSTYSYGDHSGSYQSIKVVDGESAAYKEMHKLSTTEKVTKHWDGLSTGGKIGIAAGVLGAVFIFLVAFTFYCVRQRKAGRSEAALHDQEWEKENAELMAYRTMMSKGNFAMNRESVMLEVVQAPKQQSKYSRLSGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M3AUI0</accession>
    <name>M3AUI0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_53185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF09164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757285.1">
        <property type="nucleotide sequence ID" value="XM_016909257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AUI0"/>
    <dbReference type="GeneID" id="27906394"/>
    <dbReference type="HOGENOM" id="CLU_3130010_0_0_1"/>
    <dbReference type="OrthoDB" id="5027908at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF09164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="50" mass="5842" checksum="9CCAD88C7656D776" modified="2013-05-01" version="1" fragment="single">GATNSVSQFIRVITRILIDYILYRSLPFLDDISIKRPKTNYSREELKPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M3AVX2</accession>
    <name>M3AVX2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_151229</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758357.1">
        <property type="nucleotide sequence ID" value="XM_016906683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AVX2"/>
    <dbReference type="STRING" id="692275.M3AVX2"/>
    <dbReference type="GeneID" id="27903820"/>
    <dbReference type="eggNOG" id="KOG1364">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021255_2_0_1"/>
    <dbReference type="OMA" id="PAIFDCQ"/>
    <dbReference type="OrthoDB" id="270602at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02958">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14273">
        <property type="entry name" value="UBA_TAP-C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.300.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
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        <property type="entry name" value="UAS"/>
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    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
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        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050730">
        <property type="entry name" value="UBX_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322">
        <property type="entry name" value="FAS-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322:SF6">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13899">
        <property type="entry name" value="Thioredoxin_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00594">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="466"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF10236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="535" mass="58518" checksum="E71E2A2CE4EBD561" modified="2013-05-01" version="1">MANDEDVATFTAFTSGTPEQALRFLQLTDNNVEQAVELFFSSPDLGNAAAAAGGVNSQPPAQVGPGEPITIDSDDDDDFQETVASASRPQHNVEDDEAMARRLQEEMYGSGGAGGAGAGEDDVRAPMARTTETLVGPGSYGGGGGFDPNDAGQMNAAIAQQLMQRQQMRSHRAAPGIFNQRDTRSIWNNDDPTDSEAHRRTLSRATGGSSEQSAKASHLAELFRPPVDLITPLSLADARDEGKEEEKWLLVNVQDPSIFDCQVLNRDIWKNDQIRETIKEHFLFLQYNKDDPRGSDYVNYYFSSNRDNEAAYPHIAIIDPRTGEQVKTWSGSPAPKAADFLMDLHEFLDRYSLKIGQKNPVQTKRKEPKKDISTMSEEEQLELAMQASMGAGSAAPKEEDPDTLTKTNGKGKAPATQVGNSSAMEVDEVSASETRDTPFSRIASSNVHEEPTSTGPETTRIQFRHSGGRIIRRFNIADPVRRIYEWLKSSPVEGHAGHAFELISLGKNLIDQLDVSIADAGLKQGTVMVEFIEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M3AXI3</accession>
    <name>M3AXI3_SPHMS</name>
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        <submittedName>
            <fullName evidence="2">Nuclear matrix protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_150383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016906134.1"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017925_1_0_1"/>
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    <dbReference type="OrthoDB" id="10257415at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:THO complex part of transcription export complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021861">
        <property type="entry name" value="THO_THOC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13265:SF0">
        <property type="entry name" value="HPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13265">
        <property type="entry name" value="THO COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="efThoc1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="212"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="589"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="605"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF11450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="637" mass="70972" checksum="65BABCBE1E029B63" modified="2013-05-01" version="1">MAVSSAAELEPVTIITNNLKVLLDRARQEKPETSVEPALSTSSFSKDVASLHEGIDERYDQNYRFAAAEAAIREIFYAFIHSTDINDPAFADVWNLLDIVLMCGDQGKCTPELVCWLLEELLDSQTTLGCRVVFDYLDSRRERLAQKDFHKKNLVFLRSCNELLRRLSRAEDAIFCGRVFFFLFQTFPLGDKSSVNLRGEFHVENTTKFDVEGGATEGIEPDAEPAAVPSTPKESTPPPAPTGKPGSKAVPIKAPKKAAEEVPLSASELYPIFWRLQHDFSDPTKLFQPQNFEAFKKGLACTLTKFKKTPTVVQTKAGEEDKRGTKRKLGEAAGSESSNLLDNYNPKYLTSRDLFDLELSDLAFQRHILVQAMILIDFLLSLTERAKKRLSSLTGTNKSLLYSFTLSEEDTHWATSTRAVIREGLESREDGRQYCRMVETVLTRDKNWVRWKVESCPSIVRGPVTTEEELLARKGVANFTRPRRLAEKPQGMMDLGFLEEADSGGLEPLKNPARYTTPSIPQLVDQIKMDELDAEMAMTDEEKSNIDTAMTNAKWRALRIARAADLALLDKVDSTKDLEGILSSPGISAEAETAEQNGEDAAAGPTSTAVNEDTTAVESEQFPVKVEDKVMEDAETI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M3AXW2</accession>
    <name>M3AXW2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_118860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759706.1">
        <property type="nucleotide sequence ID" value="XM_016901460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AXW2"/>
    <dbReference type="GeneID" id="27898597"/>
    <dbReference type="HOGENOM" id="CLU_1960948_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF11585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="128" mass="14045" checksum="6F6D7060869707B1" modified="2013-05-01" version="1">MPEPLTNHFQPTGQCSGDLQLPKRRDTGRAQHDSVPNRVDTASLSDSEGNAKAEAKRSSIAITTPPGPVSHRTRPHLRVKLCFPACEMFSNVFSPLTCDTSEELLSRIQVFEGPRVVLVFGTGRFKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M3AZY2</accession>
    <name>M3AZY2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8032 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_148463</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761213.1">
        <property type="nucleotide sequence ID" value="XM_016904945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AZY2"/>
    <dbReference type="STRING" id="692275.M3AZY2"/>
    <dbReference type="GeneID" id="27902082"/>
    <dbReference type="eggNOG" id="ENOG502QY0U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014950_0_0_1"/>
    <dbReference type="OMA" id="YFPVQMK"/>
    <dbReference type="OrthoDB" id="5599902at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058345">
        <property type="entry name" value="DUF8032"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22949:SF0">
        <property type="entry name" value="RE27538P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22949">
        <property type="entry name" value="WHITE COLLAR 2 PROTEIN WC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26087">
        <property type="entry name" value="DUF8032"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8032" evidence="2">
        <location>
            <begin position="318"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="633"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF13092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="769" mass="83881" checksum="ED1B6AB37B963198" modified="2013-05-01" version="1">MSAVALPPPLHGHRASSMQTYDMRQPSLLNQSNAGQQGLPPPQQPLQHPRSAGLVQQQQHRPNSPHQSHNTLNNQTSQGPYISPHSSTHSLPQQHQSPYIGSVPGIPSQHPGEAQFFGAHPSPYSTNSAGGSYASSEPNESMATQAAISRQSYPPISSYQTPQSNSPASIHSPQTDAHGRPLYGIASMPQQMYYPQYQMQQQSPYGQHPAAASHHSSMTSAPGMLMSHQQPQQQMQQPPQATPGHPQSSMLDQKPSQSSLQRPPSALAPPQATPQTPSGPGMHGHPSSTTPNGPNSSAAPGPIPATTPLVVRQDNNGVQWIAFEYSRDRVKMEYTIRCDVESVNVDELSPEFKSANCVYPRACCGKDQYKGNRLHYESECNAVGWALAQLNPNLREKRGLIQRAVDSWRNSNQDVRLRSRRVRRMAKIQNRNAAKGPPGVAGPYAQGPGSAGLPPPGMAPGSARPPNMGPGGPHMHHHHTDGNEPGGGNDVSAGNDYNSAAGHPNPSSNGQSDLASPTTGRYAQNFYPSYPQQPGVGGSSMPSVHDTMDPMHGQVSALAAPARGDADRMEEDEEHKRNLFGDVPESKRRKFILVDDNQRGTRVRVRVMLDQVKMDDMPDAHLRINAVFPRSYFPRQMRSPPGSPGARGNWDDEDDTVDEGPQGRTLVPVSLMDGSEAKLPVPRMTKSRRNKEVALNELGYRMSWGQARTFNGRTLFLQRSLDAYRNKMRSTMIAGGSDTTTIAPHFETRPGKRKWLERNKRARRAGSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>M3B1E1</accession>
    <name>M3B1E1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_84616</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761728.1">
        <property type="nucleotide sequence ID" value="XM_016910359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B1E1"/>
    <dbReference type="GeneID" id="27907496"/>
    <dbReference type="HOGENOM" id="CLU_1960947_0_0_1"/>
    <dbReference type="OrthoDB" id="285308at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF13607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="128" mass="14239" checksum="6AC3709F0B8420BE" modified="2013-05-01" version="1">MWDSESAYDIHSTGLRGHHMGGMCSTRVLKLAHHPAGVAASPAVKTTVNHPASTQSVRRDTFLQWPDVNKASDEASHAMDNPSLTSRGLDFGTSLTTYSPRNCRGRICGRRMRREKEVESVPVRHKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M3B1T9</accession>
    <name>M3B1T9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_107727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761883.1">
        <property type="nucleotide sequence ID" value="XM_016900697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B1T9"/>
    <dbReference type="GeneID" id="27897834"/>
    <dbReference type="HOGENOM" id="CLU_1846346_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF13762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="139" mass="15560" checksum="C1B0301691796B16" modified="2013-05-01" version="1">MFVILPIREVGTDGWMDEVSLFREYNVNLGLREEERRKGEERKGGKKGRKGKEGEEGEEGEEGEEGEEGEEGEEAEEGEEAEEGEEGEEGEEGEEAEEGEEAEEGEEAEEGEEGGKRGRRKERKNLNLLYYLAGLMVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M3B211</accession>
    <name>M3B211_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_65107</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761943.1">
        <property type="nucleotide sequence ID" value="XM_016909704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B211"/>
    <dbReference type="STRING" id="692275.M3B211"/>
    <dbReference type="GeneID" id="27906841"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019225_1_0_1"/>
    <dbReference type="OMA" id="DEIMLHT"/>
    <dbReference type="OrthoDB" id="2915840at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13738">
        <property type="entry name" value="Pyr_redox_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF13822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="562" mass="63211" checksum="33BF7602713021A2" modified="2013-05-01" version="1">MVMAEKHDMIVVGAGWFGLAAAKTYIELHPAEDVVVLEAESSCGGTWSENRLYAGLKSNNLHGSYEYPDFPMIPENYGITHDDHIPGRVLHKYLTDFAKKFGVFSRTRFLTRVNSLEPTSDGGWQLETECGEKQQKMYSAKVIIATGLTSQPNFPIYPGAEMFNAPYFHAKDFCRQGETIKTSRKAVVVGGAKSAFDVAYAYAEQGVEVDLVIRPSGNGPVWISYPYVMGGKRLEQLLHIRWMQWFSPCPWGGEGGALGTRIRNFLHGTAIGRFLVDKFWGGLGGEVISANGYDSNPQLQKIKPWNPAFWIGSGLSIHNYDKDFFDMVRTGAVRVHNADIERLTDHTVHLTDGTDLEADVLVCSTGWRKEPSIRFLNFGTAGIGLQHSPTEQSRLATHYDEKILSLYPKLRSQPTLNFKPKNDPYRLYRFMVPPARLTDRNIAFAGMVSSVSTSICASVQALWISAFLDDRLDRLARSEEDITKEIMLHTQWGKWRYPCGYGASLPDFVFDAVPYMDLMMRDLGLQANRKQGWKDVWQPYGPADYRGCVDEWVEKHGGGKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M3B5B5</accession>
    <name>M3B5B5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_146966</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF14957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763078.1">
        <property type="nucleotide sequence ID" value="XM_016903994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B5B5"/>
    <dbReference type="GeneID" id="27901131"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_6_1"/>
    <dbReference type="OMA" id="WILPNFP"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF92">
        <property type="entry name" value="AGL026WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="399"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="459"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="71"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF14957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="521" mass="57182" checksum="F6E6A1D215EE5031" modified="2013-05-01" version="1">MARVTHDQPSDRISGDDGPDDKNVTEYLDEVVDDVDKRPQGLEPPPLVRAMSPAEREVLEKQLTRKIDIRLLPPVIIMYILNYLDRNNIATARLAGTPGLEEDLGLTDSQYETCVSILFVGYILMQVPSNLFLNKIGKPALFLPGMMVVWGIVSLCTAAAKNFTHLVVIRFFLGFVEAAYFPGCLFFLSCWYTRKQLAFRSAVLYSGSLISGAFAGLIAAGITDGMDRKLGLPAWRWLFIIEGAVTVAVASVCFFILPNFPTTTKWLTEEERQLAVWRLQEDVGVDDWTSSKDQSFFHGFVLAIKDIKVWILMIMLLGVVSAASVTNFFPTVVETLGYNKINSLLLTAPPYILAVFCAFANALHADKTGERFLHVTLPLLVGIAAFVLAAATTSVAPRYVAMMLMVPGVYTSYVIILAWISNTISRPPAKRAAAIALINAVANASQIYASYMYSGGPRYIIAFSVNCGTLVLSIIMAAALRIILVRANKKLDRGEAVEAVVSGVVDPSNAPAVTKRFRYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M3B5P8</accession>
    <name>M3B5P8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_123488</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763243.1">
        <property type="nucleotide sequence ID" value="XM_016901843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B5P8"/>
    <dbReference type="STRING" id="692275.M3B5P8"/>
    <dbReference type="GeneID" id="27898980"/>
    <dbReference type="eggNOG" id="ENOG502R6NR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018979_3_0_1"/>
    <dbReference type="OMA" id="CPLVGSM"/>
    <dbReference type="OrthoDB" id="1924260at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052400">
        <property type="entry name" value="Zn2-C6_fungal_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF12">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="19"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF15122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="530" mass="59520" checksum="5877CF06B72D3709" modified="2013-05-01" version="1">MTGQGTGPSRRSHTKSRKGCKTCKRRHIRCDETFPQCRNCTKHQVRCDYMENVGSDAEGRSSPEQTPLSFSPDTESRIDLWQQTGSFPYPALQVFPPPQTHEYSKNDLRLIHHLSAISNDLMLKGTTNLTIWTQKVPKFLSIAATYPFVMHALLSFSANHLAWSRSSNETRNLHIQHGTIALRGLHEAIGNFSHQVADAVLACSLLLLWQATDWRSWSSLRAGIQSVLSAMHSWKYESIFAEYITEEDLFVGAYPSRRPSLDEENRNTILSNTIHASQRLQGFVVGHEAESYWIGQLLQYLQRLHVSSPAQTPDEQYSHLYLLRKWLFWVPTLLLQTQGGRGPALLTLSHFYATALALEPLYPDLGSAFCARVALSPLEQIISVTDAMQSQRVMDQNSMEIASLMHFPQQMALDFRNRVIQSQQMAMQHGSPMVVTPDTLNYTSIGNPSPAFAPSLLHPVPSQSAAMHASYLEVPSVPPSFTSVQTGWSAMPSPNFPPQSYTPREEQQIYGYSLGGFRGGFVNTPDPIWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M3B710</accession>
    <name>M3B710_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CAP_GLY-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_147449</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TBCB family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763738.1">
        <property type="nucleotide sequence ID" value="XM_016904306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B710"/>
    <dbReference type="STRING" id="692275.M3B710"/>
    <dbReference type="GeneID" id="27901443"/>
    <dbReference type="eggNOG" id="KOG3206">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067577_2_0_1"/>
    <dbReference type="OMA" id="DQYEQRT"/>
    <dbReference type="OrthoDB" id="5295208at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF85">
        <property type="entry name" value="TUBULIN-FOLDING COFACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14560">
        <property type="entry name" value="Ubiquitin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00845">
        <property type="entry name" value="CAP_GLY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="5">
        <location>
            <begin position="181"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF15617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="245" mass="27234" checksum="CD08711F5C40740F" modified="2013-05-01" version="1">MAAPAADVALLIRSENSASERRVSPAWTIAQLKARLEPITGVPAGCQRLSLKVASQPAMMIEAADEEATQVGAWPLQAYAELQIVDTRPPGSRTNYTDVSSVEKFELPKEEYESRTDSVLAWKKAHKLGRFDPNAPSIEQQKVNASYREVEERGITQNARCRLLPESDHRRGTVHYIGDIPEITGSVGAWIGVKLDEPTGKNDGSVQGKRYFECQPNYGVFVRPERVEVGDFPELDEFADEDDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M3B7Q1</accession>
    <name>M3B7Q1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_61184</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763998.1">
        <property type="nucleotide sequence ID" value="XM_016909553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B7Q1"/>
    <dbReference type="STRING" id="692275.M3B7Q1"/>
    <dbReference type="GeneID" id="27906690"/>
    <dbReference type="eggNOG" id="KOG0022">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_14_1_1"/>
    <dbReference type="OMA" id="DMQSGET"/>
    <dbReference type="OrthoDB" id="6260732at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08278">
        <property type="entry name" value="benzyl_alcohol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43350:SF2">
        <property type="entry name" value="GROES-LIKE ZINC-BINDING ALCOHOL DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43350">
        <property type="entry name" value="NAD-DEPENDENT ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="8">
        <location>
            <begin position="30"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="7">
        <location>
            <begin position="210"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF15877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="385" mass="40926" checksum="171AFB50DE7665FD" modified="2013-05-01" version="1">MTSTQAIVCHDTYANKGWKLEDIKVREPQEGELLVEMVASGVCHTDVLIGGLANDGNPMAMYPRVLGHEGSGYVRKVGPGVTVAAEGDPVLLSFAFCDKCEICKTGGHSHCDHFTPLNFGPHTAFHAAEGKESSGGGSEILGQFFGQSSFANFSIVKSSSVVNVKGLVTEKRDLQLFSPLGCGIQTGSGTVVNVSGAGPNDALCVMGLGGVGLSAIMGAKIQGCRMIIGVDRVESRLKLAKELGATHVIDGSKLDEGKTLGDVIKELADGVGPSITIDTTGAPVLMDAGMQFTRNRGKYIQVGSPPFDYTLNSVQGFAFMVAGKQWIGAVEGGAYPPKYVPQMIQWYREGKFPIDKLMKLMPADQFDQALHEMHSGETIKPILTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M3B8K2</accession>
    <name>M3B8K2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Periplasmic binding protein-like II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_37845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF16187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764308.1">
        <property type="nucleotide sequence ID" value="XM_016908683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B8K2"/>
    <dbReference type="STRING" id="692275.M3B8K2"/>
    <dbReference type="GeneID" id="27905820"/>
    <dbReference type="eggNOG" id="ENOG502S0QG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026974_5_1_1"/>
    <dbReference type="OMA" id="NDVQWVR"/>
    <dbReference type="OrthoDB" id="124329at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30006:SF2">
        <property type="entry name" value="ABC TRANSPORTER SUBSTRATE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30006">
        <property type="entry name" value="THIAMINE-BINDING PERIPLASMIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13343">
        <property type="entry name" value="SBP_bac_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004031250" evidence="2">
        <location>
            <begin position="20"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF16187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="369" mass="41031" checksum="0E52E320718D30E1" modified="2013-05-01" version="1">MRTSHISAALSALAVCASAYSPLTDVDTRSLDEIYAEARKEDGILQVFWGGDAAAQGDAIKTGWAQRFPDVKMNLTVELSKYLDNRIDRGHLQGIHTADVVVVQTLQDFRRWKAEGKLLRYKPATFEDILYAEKDPDGYFMAQAIMTFGAFIYDETKINASEIPTSYASMPDKKWKGKLILTYPNDDDAVAYQFSLMVNRYGFQWLYDLAQNDVQWVRGTGTPVLTMGSRHNDTSFGRVLSFTSYDSGASFIGAKNPEAPEQYLTWAQSGAILADTPMPESAKLFMSYLTSVERQNATAATGTASILNSVNAMYGLTPDSNATQLSSFRLWEQDRNTVEWWKNLFEEVLGTAQGPGPMVMYPDNAPLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M3B8K6</accession>
    <name>M3B8K6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_131714</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF16192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764313.1">
        <property type="nucleotide sequence ID" value="XM_016902444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B8K6"/>
    <dbReference type="STRING" id="692275.M3B8K6"/>
    <dbReference type="GeneID" id="27899581"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_375153_0_0_1"/>
    <dbReference type="OMA" id="EISARCM"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038725">
        <property type="entry name" value="YdaG_split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF6">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE AN1598-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16242">
        <property type="entry name" value="Pyrid_ox_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="General stress protein FMN-binding split barrel" evidence="8">
        <location>
            <begin position="24"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="643"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF16192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="740" mass="84034" checksum="807CC3E41491581F" modified="2013-05-01" version="1">MTTTAGNDLYHERNYEPHASMDEKMTDLAKFMKAHSICMVSTMRNGDWGEEISARCMGLAATERAGAELIFHTNTESSKTDHLAKDPRVNVSFLDPAAGQWASVFGTASVVDDRDQVRKYYSPALKNWFGDLGNGTNDGGPNDPRIGIIKVHAESVAYAIVEPGMLGKDASNYDGHQDDMPRINKLRKLTKKELDDWRAAHAKQRIKNDLRQQIPLYTFEDRPDTYEHYVKSTRQLHYGGYQKYIRHERPYRVKTSAGGERIILPFKYLPEIKNASQKVMSLPDEMEDLLLMRYTGVPQRTDSGTKVVRVDITRNLGNFVDAMNEECIYGFEKYMPCHGESWQIVKPYHVFARIVALISGRVLVGEELCRNEDWIRLSMDFSTHAFGAARTLRSGNKWPWSMWLASYTEPAVKAILERRREAEALMKPVCEARLRRRSTNDANWKIPEDGIQWLLDSHSHSGESAEEVVKSQLRLTMAAIHNTTMSVTNDLFDLLSHPEYIPILRDEARQVLAEEGGGDGGGGGWTKQGLTKMRKMDSFMKESQRMNPSTPITCKRKVVENFALHDGLILPRGCHVAFTSDAVNRDAAIYERPDEFDGLRFYRLRTARPAAEKTGTISANETKYQFVTATQEYQNWGAGGHACPGRFFASNEIKLMLAYLVENYEFRWKDGEGRPESAVIDWNILPDREKEVMFRRRVAQSPVVKLQQPCAVVSSQRGYNPALLRLGGSFRASTSTVRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M3BQC3</accession>
    <name>M3BQC3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Tethering factor for nuclear proteasome STS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_152027</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Involved in ubiquitin-mediated protein degradation. Regulatory factor in the ubiquitin/proteasome pathway that controls the turnover of proteasome substrates. Targets proteasomes to the nucleus and facilitates the degradation of nuclear proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 9">Binds the proteasome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the cut8/STS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756459.1">
        <property type="nucleotide sequence ID" value="XM_016907199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BQC3"/>
    <dbReference type="STRING" id="692275.M3BQC3"/>
    <dbReference type="GeneID" id="27904336"/>
    <dbReference type="eggNOG" id="ENOG502RNK4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033658_0_0_1"/>
    <dbReference type="OMA" id="DYTPHFL"/>
    <dbReference type="OrthoDB" id="10061064at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071630">
        <property type="term" value="P:nuclear protein quality control by the ubiquitin-proteasome system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031144">
        <property type="term" value="P:proteasome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1590:FF:000001">
        <property type="entry name" value="Tethering factor for nuclear proteasome STS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1590">
        <property type="entry name" value="Tethering factor for nuclear proteasome Cut8/Sts1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013868">
        <property type="entry name" value="Cut8/Sts1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038422">
        <property type="entry name" value="Cut8/Sts1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28032">
        <property type="entry name" value="FI02826P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28032:SF1">
        <property type="entry name" value="FI02826P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08559">
        <property type="entry name" value="Cut8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF08338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="308" mass="34549" checksum="1F738369AEE61C70" modified="2013-05-01" version="1">MNSILPPSHAAPHLLGNNRLSPSRDPYGIPSSMASRKRKASEEPDHDRMSTSPSASPSMAGRPLPHARSIKRTRTGAVQGRPLALPRLLETLSADQMRNLLQNICDQHPELQQAIVTKAPRPSVDSTLQVLSRYEDSFRQAFPLGNRPTSDYSYNRVQTQLRELIEAVREYTPHFLPPHETTDSLSFAYLDSVTNMIHRLPDWDTFQHQRHKSEAYDEIAKAWALVIQEAAKKAGGFHLQFGGWDHKVVEHNQKSGGKMEEAVNEVKVALGFMQAPSSNTPGVSEERASIRQQLFSGNFTQLAYSRYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M3BR37</accession>
    <name>M3BR37_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AIP3-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_152208</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756709.1">
        <property type="nucleotide sequence ID" value="XM_016907305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BR37"/>
    <dbReference type="STRING" id="692275.M3BR37"/>
    <dbReference type="GeneID" id="27904442"/>
    <dbReference type="eggNOG" id="ENOG502QS95">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005287_2_0_1"/>
    <dbReference type="OMA" id="WSRKQAS"/>
    <dbReference type="OrthoDB" id="783096at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005519">
        <property type="term" value="F:cytoskeletal regulatory protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1540">
        <property type="entry name" value="Actin interacting protein 3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022782">
        <property type="entry name" value="AIP3-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005613">
        <property type="entry name" value="AIP3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056279">
        <property type="entry name" value="Aip3p_Bud6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051825">
        <property type="entry name" value="SRCIN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22741:SF10">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN CG32809"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22741">
        <property type="entry name" value="P140CAP/SNIP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03915">
        <property type="entry name" value="AIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23153">
        <property type="entry name" value="Aip3p_Bud6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00806">
        <property type="entry name" value="AIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Actin interacting protein 3 C-terminal" evidence="4">
        <location>
            <begin position="507"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="152"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="363"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="838"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="946"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="809"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="196"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="287"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="389"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="848"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="946"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="967"/>
            <end position="997"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF08588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1042" mass="113572" checksum="B32D22E4CFF2C0DD" modified="2013-05-01" version="1">MSGGQPTAAMPAGPEDAANGQRGSGGSTRSAGSSRSRQNPQQQLSTIEKSVTHLLVATKQLLETLTMWSTGRATEGEVSDVYVRLGYEFNIACRAFNAIGVDTSDLGPVPDLLRTILEETLSQDASQQSLERYLPRIRDIIINLLHGLKKKQQRLRQRGTRDGGESSTRAPRQASTASNVSSGTTLTEQLEDVPSRHSSSRSFAQRQGSGDLTGPDLPPRTTSATGGKSSPTRSTLSPQNSVRQRPHEQDARSATSGSSISSDTMQNMPVIAPYPESETMPTNGVPDRPPSPEPPKPPPKVNDALSALQRGGELERRASRRFSAYQIQKHLGTSLTGIPAIPAAQNSPIPNRGRDVRESLNAVRSRGSYMHNRVKSKTLKSQLESSSPNREHDVRRISEESSSQPQDDLPPPSKPFAYEYNDEIVKTPEDKLGTTPFSSLVEAPSATLNGPIDEPFVPSSDFVAPTRTPTIKRPQRESIRQGREYTPPVSQYIPEGSPQSGTPLVLFLQYKSKIKKFTLPDGGDLSLARLQLAFIEKFAWNTHNNGVDLPEIYIQDPVSGVRHELEDLNDVKERSVLVLNIEALDEVKRHFDDGLGSLRRVVESIKTSVDEQSSSLQRVSDRQQDTAKELASIAAAPPPVPAVPITGGTTASSKDMTGQLKEVQGLRRDIAVVRQTYNSFVQDMQASMTAIRTKASTVKKAAAEAAIPDMDNNTGRSYVNNGKKTLSNDSERIVNKVDDLQDLVEDLRKDVVSRGVRPLPRQLEEVSKDISTATSDLKKLQEFLKREKPLWTKIWEKELQVVCDDRDLLTMQEELAADLEDDLEKASQTFALVEEATKQQNLQGHDGASATTSARSTSRTLALKPLADPHEAKDSVLGEVRALQPNHESRLEAIERAERARHKELENRKGGEFQRELGHFVEEGKLKKTGGHEEVERLRKVREEQARQEASRMMEQRRQLMAEKQAAEAAAAEEAAAGEAAAGEAAAGEAAASGEGEAAAESEETSAGLEAPKEEKDAVSDGEGAFVDANEEVGTPSEAAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M3BVI6</accession>
    <name>M3BVI6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_126900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759455.1">
        <property type="nucleotide sequence ID" value="XM_016902111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BVI6"/>
    <dbReference type="GeneID" id="27899248"/>
    <dbReference type="eggNOG" id="ENOG502SRM2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096588_0_0_1"/>
    <dbReference type="OMA" id="KQNYAHD"/>
    <dbReference type="OrthoDB" id="3438340at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021641">
        <property type="entry name" value="DUF3245"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11595">
        <property type="entry name" value="DUF3245"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF11334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="252" mass="26950" checksum="1C8801D167B9E20D" modified="2013-05-01" version="1">MGDSADHITEADIWLSRSNIVQARSQRLLQSWLPTAQNTASTPAEDNDDQDDFVAMTESAGLGTAPAESEFEVDGILKKRHASSNDKLLEQLLGKKAAAAKKKEQALARQTKTNIALGRAAPVPAPAKGTSATPSRPVDDDSEDEDEPGRAATFTGNRVTRDNNLPAYAATGSSRRGATPIDEDAEPPDPRDDAATIAAMKNGTSQAHQEPPASEDGGPPRKKNKSTSYLDELLSKKKQRKKTKNKTFTGTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M3C052</accession>
    <name>M3C052_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SEPMUDRAFT_148917</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the creA/MIG C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761822.1">
        <property type="nucleotide sequence ID" value="XM_016905225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C052"/>
    <dbReference type="STRING" id="692275.M3C052"/>
    <dbReference type="GeneID" id="27902362"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036230_0_0_1"/>
    <dbReference type="OMA" id="YHMARSH"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000433">
        <property type="term" value="P:carbon catabolite repression of transcription from RNA polymerase II promoter by glucose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043609">
        <property type="term" value="P:regulation of carbon utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000089">
        <property type="entry name" value="DNA-binding protein creA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000152">
        <property type="entry name" value="DNA-binding protein creA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051007">
        <property type="entry name" value="creA/MIG_C2H2-ZnF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47428">
        <property type="entry name" value="REGULATORY PROTEIN MIG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47428:SF1">
        <property type="entry name" value="REGULATORY PROTEIN MIG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="111"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="206"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="361"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="463"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="516"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="21"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="261"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="275"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="299"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="361"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="419"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="527"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038023"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMF13701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="554" mass="60417" checksum="87FBF01D47C7883F" modified="2013-05-01" version="1">MLSSLLNPEHPQVQQHPRSETATPNTATSPASSSVAPVTDNTTSTSTTPPASTSMAGSTMTMPAVAPSMQSQDEHRPDLPRPYKCPLCDKAFHRLEHQTRHIRTHTGEKPHACQFPGCTKRFSRSDELTRHSRIHNNPNSRRGNKQHVAAATAAAAAMQAGMYDNSTLQQLNHLQQLNQMNQMQQLSHMSQLSQMNQMNQMNQMNQQPTQFNTPNYLQQSPLRNGMQTPPVMHQQSQPQTQPPPQPQQQPPSQHHPQQHQLPPPVNPIMPPPVQKATQSAPSSQLTSPNVSPPHGYASTYHSTPGSYITRNTSGDLSPAQGSSYASGPGINLLATAASQVERENNAQIPNAHLSLPTRHTTYHHSYNTGRMPSLSSYHYSSNPTSQPMSRSHSHDEDDHRPHKKSRPGSPQSTAPPSPSFSHASASPTPDHTPLATPSHSPRLRPQYFHNGVQLPTLHHLSLAHQPPPALAPVEPSADGLQPYVPAQHSGLRISEIMEAGDGAQRKLPVPMVAAKDQTYQVRDIKDISNPSSGINSGNSSARQSEAGNDLADRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M3C0H0</accession>
    <name>M3C0H0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_125502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502SVNY">
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    </dbReference>
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    <dbReference type="OMA" id="FCNATTS"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004031532" evidence="1">
        <location>
            <begin position="19"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF13826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="227" mass="22997" checksum="1533BAD224553ADF" modified="2013-05-01" version="1">MRARTATTILTAATTIAAQSVVVIIETSHGGAGVGLTNTSITVPLSIYYTNPALDAVSTLYLTQASGVNLTAVTCTPYRNADASDNAGLPFNSTTPSFISTNTQQIGSVFCNATTSPNSKPPPQTPIYSNTTTSAHSAIPTAHNVTSVFVTTVPASAKPSPSTFTSVETFSGPNGPTTSTYTAVVNVPAQTTTAAPSLNSEGAAAPVRRVGTWMAGAVAVLGLMVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M3C1F0</accession>
    <name>M3C1F0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_106499</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762252.1">
        <property type="nucleotide sequence ID" value="XM_016900638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C1F0"/>
    <dbReference type="GeneID" id="27897775"/>
    <dbReference type="HOGENOM" id="CLU_894774_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF14131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="311" mass="34234" checksum="49B45E04F2B1CAC8" modified="2013-05-01" version="1">MGFFKPTLNSKHDHLSLIVLGAGAFALGLTICRLWMNRPDFEQHKAPSNSENPPHEDEHDNDHEDDHERLRLSSAPLTPIRGREYSLLDDFPLPPSSSTIDELAKPASLNGHSSHLLQQEEQQQEYQQQTPSSTSQSTIPSPTSPFTPPSHSPSSSAEEEQQKQEQNQNQNQNPQQTQQEKFNWTNFSQNENLLPTPPPPFSSSSSSSSSPHFSPSPSSPSSSSSSSSPPSPKRKQTHQTHQNPSSSPNFFSGTSAWPRELPRRMIVPPELTTTTATNEQPFIFRGMASSLSSLLQEEKEGSCGGSGGEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>M3C2V3</accession>
    <name>M3C2V3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Urease</fullName>
            <ecNumber evidence="2 9">3.5.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 9">Urea amidohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SEPMUDRAFT_148266</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>urea + 2 H2O + H(+) = hydrogencarbonate + 2 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20557"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Ni cation</name>
            <dbReference type="ChEBI" id="CHEBI:25516"/>
        </cofactor>
        <text evidence="11">Binds 2 nickel ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1.</text>
    </comment>
    <comment type="PTM">
        <text evidence="10">Carbamylation allows a single lysine to coordinate two nickel ions.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.5" evidence="2 9"/>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762722.1">
        <property type="nucleotide sequence ID" value="XM_016904815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C2V3"/>
    <dbReference type="STRING" id="692275.M3C2V3"/>
    <dbReference type="MEROPS" id="M38.982"/>
    <dbReference type="GeneID" id="27901952"/>
    <dbReference type="eggNOG" id="ENOG502QPKB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000980_0_0_1"/>
    <dbReference type="OMA" id="DTMDGVH"/>
    <dbReference type="OrthoDB" id="1708534at2759"/>
    <dbReference type="UniPathway" id="UPA00258">
        <property type="reaction ID" value="UER00370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035550">
        <property type="term" value="C:urease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00375">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00407">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00390">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.280.10:FF:000001">
        <property type="entry name" value="Urease subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.150.10">
        <property type="entry name" value="Urease, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.280.10">
        <property type="entry name" value="Urease, gamma-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01953">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008221">
        <property type="entry name" value="Urease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011612">
        <property type="entry name" value="Urease_alpha_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050112">
        <property type="entry name" value="Urease_alpha_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017950">
        <property type="entry name" value="Urease_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005848">
        <property type="entry name" value="Urease_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017951">
        <property type="entry name" value="Urease_asu_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002019">
        <property type="entry name" value="Urease_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036461">
        <property type="entry name" value="Urease_betasu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002026">
        <property type="entry name" value="Urease_gamma/gamma-beta_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036463">
        <property type="entry name" value="Urease_gamma_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029754">
        <property type="entry name" value="Urease_Ni-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009671">
        <property type="entry name" value="PRK13192.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009686">
        <property type="entry name" value="PRK13207.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01792">
        <property type="entry name" value="urease_alph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00192">
        <property type="entry name" value="urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00193">
        <property type="entry name" value="urease_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43440">
        <property type="entry name" value="UREASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43440:SF1">
        <property type="entry name" value="UREASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00449">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00699">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00547">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001222">
        <property type="entry name" value="Urease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01752">
        <property type="entry name" value="UREASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51278">
        <property type="entry name" value="Urease, beta-subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54111">
        <property type="entry name" value="Urease, gamma-subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01120">
        <property type="entry name" value="UREASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00145">
        <property type="entry name" value="UREASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51368">
        <property type="entry name" value="UREASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9 11" id="KW-0533">Nickel</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Urease" evidence="14">
        <location>
            <begin position="404"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="12 13">
        <location>
            <position position="595"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="409"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="11">
        <location>
            <position position="492"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="11">
        <location>
            <position position="492"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="494"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="521"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="547"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="635"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="10">
        <location>
            <position position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001222-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001222-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR611612-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMF14601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="840" mass="90971" checksum="D0DCD04DDF64544F" modified="2013-05-01" version="1">MQLAPKEIDKLLISQTGFLAQRRLARGVRLNHTEALALIASVLHELIRDGEHTVADLMSLGTTLLGRRHVLPSVPHTLTEMMVEGNFRNGTYLVTIHNPVATDDGNLERALYGSFLPAPALEKFPWPPVEGLKAWEHEKMPGAVVAVKGAAGKIALNEGRRRIKLKVTSKGDRPIQVGSHYHFVETNPKLEFDRIKARGMRLDIAAGTSVRFEPGESRTVTLVEIAGNKVIRGGNDLAAGGIHAVSEDGLIQRLREGGFLHVEQPRADLVLENYTMDRESYVAMFGPTTGDRVRLGPTDLWIQVERDLTVYGDECSFGGGKTIRDGMGQASGRLDKDCLDTVVTNALIVDYTGIYKADIGIKNGIIVGIGKAGNPDVMAGVHPDLVIGGATDVIAGEHKIVTYGGFDSHIHFICPQQAYEAVASGITTFLGGGTGPSTSTCATTCTPSTKMIEWMLQACDVLPINVGVTGKGNDADPTGLREQAEAGVCGLKLHEDWGTTPKTIDTCLSVCDEYDIQTLIHTDTLNESGFVETTVAAFKDRTIHTYHTEGAGGGHAPDIISVVEHPNVLPSSTNPTRPYTGNTLDEHLDMLMVCHHLSRNIPEDVAFAESRIRAETIAAEDVLHDLGAISMMSSDSQAMGRCGEVILRTWNTAHKNKVQRGFLPEDEGTEVDNFRVKRYISKYTINPAVAQGMSHLIGSIEPGKLADLVLWDPANFGAKPKQVVKGGMVAWSQMGDPNASIPTVEPVMMRPMFGAMVPSTGIAWVSDASVKNGKVGGYGLKKRIEAVKNCRSIGKKDMKFNGVMPKMKVDPERYIVEADGVEMKAEPALTLPLSQSYFIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M3C2Z3</accession>
    <name>M3C2Z3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1365-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_9695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762767.1">
        <property type="nucleotide sequence ID" value="XM_016910655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C2Z3"/>
    <dbReference type="GeneID" id="27907792"/>
    <dbReference type="eggNOG" id="ENOG502RGVU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020424_1_0_1"/>
    <dbReference type="OMA" id="DVWMKDF"/>
    <dbReference type="OrthoDB" id="3340520at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010775">
        <property type="entry name" value="DUF1365"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33973">
        <property type="entry name" value="OS07G0153300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33973:SF4">
        <property type="entry name" value="OS07G0153300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07103">
        <property type="entry name" value="DUF1365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF14646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="492" mass="57569" checksum="A45718C536764208" modified="2013-05-01" version="1" fragment="single">RTNHSRTFPKKHSFSYSYLFVGVPVGMQGRIGKVFSVDSELRGWFDICAADYLNRSDDQHTLESKLRRYLHTRGVTSRDYAFAYLVTAPRFLGYSFNPVSFWYIYDSNASLKYMILEVNNTFDERRMYLLKSDATMADKDRNGESGNAMVFTDSWEKDFHVSPFNSRKGSYSLRAIDPLAGYEQTGHVRIDNTIVLKSSKEHTKIVARVFSEGTPKEPENITTLQLVKFISAWWWVGLATSPRIVWEAQKLYFRRKLHVWYRPEVVPTSIGRTYTTEEAALEEIFRDFLTQAVEHAERPLRVIYEPAHHQHDEIVLYSSNFTYKEDHASTLTLKILSPAFYSRFVHYAHAKEAFDRECLFTDEKNRTLTIDGTQALPDLFHAMAHTSRIATTTPNDMSAVERLRWKFLLRRLRCPPAVASYSERPRRASEQQQQQQYKVHDIRSFHFSEMDHYVQHTHHRETYRRILVRLFLAERFAMGIPLLISLGDGILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M3C5H7</accession>
    <name>M3C5H7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_39581</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ELP5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763637.1">
        <property type="nucleotide sequence ID" value="XM_016908751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C5H7"/>
    <dbReference type="STRING" id="692275.M3C5H7"/>
    <dbReference type="GeneID" id="27905888"/>
    <dbReference type="eggNOG" id="ENOG502QQIZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050414_0_0_1"/>
    <dbReference type="OMA" id="WEPESTF"/>
    <dbReference type="OrthoDB" id="166907at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19496">
        <property type="entry name" value="Elp5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019519">
        <property type="entry name" value="Elp5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15641">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15641:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10483">
        <property type="entry name" value="Elong_Iki1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="285"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="285"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="316"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="348"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF15516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="361" mass="40623" checksum="53684FF5B9DE2835" modified="2013-05-01" version="1">MAPSSLQHRRTHNLLLISKLLNQRDAASPFTLVLDNLEQTGKPVVAEYLRRANTSKIKVIFVSFETLRRPRTADVFIEAWRQSLQSWQTEVVNHLRAEATQSEFIPFKKLLVFDTLNPLSATQSSNLPALLSSFILPTSSLLALYHTDVPLPIPEIYYSNNNYNNNTGHQNPYAPSALTLLRYLATTILTAHSFHHVLAQKAARERSHAEPIFGLEAGVDGVLQSLGANGLEGVVLEMEHRRKSGRGVREWYFLPMVGRQPAMMTTIKGRESGIMLLEDHPRYRTPEERKKVDADAAAREEGDGSESSTTTFELGLTEKQRRDRDGVVLPYYDAQRGGGDGGRILYDMGEEDDFDEEEDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M3C7G3</accession>
    <name>M3C7G3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_115236</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF16191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764312.1">
        <property type="nucleotide sequence ID" value="XM_016901141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C7G3"/>
    <dbReference type="GeneID" id="27898278"/>
    <dbReference type="HOGENOM" id="CLU_1086524_0_0_1"/>
    <dbReference type="OrthoDB" id="5531344at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF16191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="256" mass="27300" checksum="C9954229AE1A0B8F" modified="2013-05-01" version="1">MDGIISGAIGCCCLALAGLTILPMLLLSPLVIMCGGPQALLGTWGIWFALLVYGLGYSMCSGALLYDWTYRRTIQRRQHLAEKRARIAAEKLFVARSSPSTPTALAPGPRPILTPRSTTTIASRPSSIRFATPAQLPSTPSSRRPSLVAAEHDEALHLASTFRANIRENDTHYKYDVSLDGASRLSSRRPSRAGTDLSAAMGSGSATPRIARSRAGSFSFDFGAMTPSRNGSTSNLMPGSDSSKRQKCAHVESEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M3CA69</accession>
    <name>M3CA69_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Translation machinery-associated protein 16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_92869</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TMA16 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756876.1">
        <property type="nucleotide sequence ID" value="XM_016910596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CA69"/>
    <dbReference type="STRING" id="692275.M3CA69"/>
    <dbReference type="GeneID" id="27907733"/>
    <dbReference type="eggNOG" id="ENOG502RY79">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106785_1_0_1"/>
    <dbReference type="OMA" id="FWMPDLS"/>
    <dbReference type="OrthoDB" id="270284at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.170">
        <property type="entry name" value="Translation machinery-associated protein 16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021346">
        <property type="entry name" value="Tma16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038356">
        <property type="entry name" value="Tma16_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13349">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13349:SF2">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11176">
        <property type="entry name" value="Tma16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF08755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="179" mass="20828" checksum="75017A1224950ECA" modified="2013-05-01" version="1">MPSQHSKVVKHVHKKKGAKISSLHENSRDAKRIRNASARDERVANMHSTRQKQNRTFLDRIAFFQDRLPETLHPLSVDEIKSHIEEYISRYDEELATLKSERRPGRPASTRQALLEQAVEKERQEFESGFWVPDCQDESTLMKLDGWKGQWLELGVMRFVRIDKEGVMKESSFPPRGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M3CBC6</accession>
    <name>M3CBC6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_121033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF09155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757276.1">
        <property type="nucleotide sequence ID" value="XM_016901657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CBC6"/>
    <dbReference type="GeneID" id="27898794"/>
    <dbReference type="HOGENOM" id="CLU_723942_0_0_1"/>
    <dbReference type="OrthoDB" id="3650777at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF8">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="382" mass="42682" checksum="68EF8D80039BDFA8" modified="2013-05-01" version="1">MLQPGEQSSSSPPPASLPLPPSPLSHKMLPPPSPSSPPHPNILPPPSLSLPLRPHHNMLPPSSPPLPPSPPHHEMVPPPSQPEAPFQKQQKPLFLNIAAELRNRVYALALKLDGEIGFSCCRDWDSGKLSIKRDDIVPWPHPWPQSHRSARKDDPTNQIDLRKLAVGLLAVCRQINFEAAPVLYGANKFAFYGASIASHTIGSFGGNFVHLRKLKLGNVKNTISGQFWRHSPEDPWYRTQLNVFVDLMSTLDRKEKGEVLELTLGFNSHPRGSELDSSPYYGEDDPCPKMEVRFLKAVLPFMGQSHYFGEGKDSKGRLQIELFGEGGLKGSFQQKSRMKRWASASGIILRKIRGYMEEDPSLATVPLKSRYIGDCFPYDWKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M3CCL3</accession>
    <name>M3CCL3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cell division control protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_165816</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the CDC6/cdc18 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758263.1">
        <property type="nucleotide sequence ID" value="XM_016908189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CCL3"/>
    <dbReference type="STRING" id="692275.M3CCL3"/>
    <dbReference type="GeneID" id="27905326"/>
    <dbReference type="eggNOG" id="KOG2227">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012774_2_0_1"/>
    <dbReference type="OMA" id="LFEWSLH"/>
    <dbReference type="OrthoDB" id="1926878at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000547">
        <property type="entry name" value="Cell division control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049945">
        <property type="entry name" value="AAA_22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016314">
        <property type="entry name" value="Cdc6/18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015163">
        <property type="entry name" value="Cdc6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054425">
        <property type="entry name" value="Cdc6_ORC1-like_ATPase_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF26">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22606">
        <property type="entry name" value="Cdc6-ORC-like_ATPase_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09079">
        <property type="entry name" value="WHD_Cdc6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001767">
        <property type="entry name" value="Cdc6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="205"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="148"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR001767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF10142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="634" mass="68989" checksum="66A598316A486BF0" modified="2013-05-01" version="1">MSRIPTTILGKRTRSAAAAADTTTTTTTTRAKRRLAVNAPSDENENPFTNKRQHVDASENEEDLDAREPPTKKTRSSARRATPKHTSVQSPIDLSPALVKSHFRVGKSGVHQESKLDQDKENAPQTPRHRDALSKKVPITPRHRVLASQATPRSGRTPSTPSQASVYNQARQLFARCSNPGKLVGRDSERDELSAFVSTAIGSKSSGCLYVSGPPGTGKSALLNEIIEEQTKDRNVPVSVVNCMSVRSTKDLSQKLSNDLDLREDAGFDYLKSVFVREKAKDKKKYLVVLDEVDILVDLDLELLYSLFEWSMQPTSRLILIGIANALDLTDRLLPRLKARNLKPDLLPFMPYTAAQIVEVITSKLRSLAPADSTALPFFHPAAIQFCAKKVAAQTGDLRKAFDICKRAIDLIDIETRDKASALELSPSKTPLMENVNLSSPAGSPQKITTVYTIDTAPKATIAHMAKVTAQAFSHGTTQRLGTLNLQQKAVLCALAALERKKRETQVDRTMFATPSKSNSSAPSIKQLYDAYSTLCKRENLFHALSSVEFRDVVSGLETLSLVSAVDGGKNGSFAIPMTPSRTPGRPKKNGFAGPALTEERRIASSVGLKELNDALDGPAGELLKEMLVGGALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M3CFB3</accession>
    <name>M3CFB3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_149157</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760624.1">
        <property type="nucleotide sequence ID" value="XM_016905378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CFB3"/>
    <dbReference type="STRING" id="692275.M3CFB3"/>
    <dbReference type="GeneID" id="27902515"/>
    <dbReference type="eggNOG" id="KOG0029">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004498_10_1_1"/>
    <dbReference type="OMA" id="RAVVKCC"/>
    <dbReference type="OrthoDB" id="5046242at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF410">
        <property type="entry name" value="LYSINE-SPECIFIC HISTONE DEMETHYLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="2">
        <location>
            <begin position="77"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF12503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="538" mass="59424" checksum="37D45BB7A692D773" modified="2013-05-01" version="1">MSACQNNMAHLYHQTTHICASPPKKPSNRGSGLGEDSISVSPSTTLQAETPAAVDKLAPRTGAEGKKVKLVVLGAGISGLRAASCLQRHGVDVVILEARNRIGGRIHTTRNEAGAPRDIGAAWLHETSQNKLVKLISKLKLDYYYDDGLPLYYTEQGRAGAQFKAKKVADEAADHMQWWYETHPDAPDQTASDFVNSFVDKHELITEDERLWAPQAFKEVELWIGTTIETASARHLSYFVTERNLYMKGGYDNVVKWVADSLLPDTVHLNKTVDHISWSEDGSCTLEYHDASGNVAVMEADAVISTLPLGALRRNLVTFDPPLPDDMQLALSKFSYGALGKIFFEFADVFWSKDNDQFMFYPTPPALEEDSYSTSPSSSSSNEPDNILNYATVTINLWIMTGGKELCVQIAEPLTQRIEAMTDKQAIYKFFEPLFKLLRTEPYKTLPRLINVETTHWTQDPLAGYGSYSADKVGDEPELLLNALENHKGSRLQFAGEHCTMVANGCVHGAFATGEKAAKNILNTFGIAYDGGDMVSID</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M3CG81</accession>
    <name>M3CG81_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_149356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760924.1">
        <property type="nucleotide sequence ID" value="XM_016905506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CG81"/>
    <dbReference type="GeneID" id="27902643"/>
    <dbReference type="eggNOG" id="ENOG502R91X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1240114_0_0_1"/>
    <dbReference type="OMA" id="WVRDEAN"/>
    <dbReference type="OrthoDB" id="4143071at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF12803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="209" mass="24065" checksum="B20304BD3EB7D1F3" modified="2013-05-01" version="1">MATVEQAQAYHREHPDGHGPAPGETAEQHAAHAYFQPIRHWGLGRKQEAVLFYCFTIPSWIFCIVSAALGSYDKTFSHSFIACATIWLVLWATAWLQTAVLMAQRASWVRDEANLKDRKQYLYLSVRLQRLMIVTAIICLPTFIQAYVQRDSYDDLAYWLVFLLFFIFNTVGCVMNAYNNITWESDRLHYEEGEPPMKHTKLAILGIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M3CH96</accession>
    <name>M3CH96_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_148549</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ornithine cyclodeaminase/mu-crystallin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761294.1">
        <property type="nucleotide sequence ID" value="XM_016904992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CH96"/>
    <dbReference type="STRING" id="692275.M3CH96"/>
    <dbReference type="GeneID" id="27902129"/>
    <dbReference type="eggNOG" id="KOG3007">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042088_0_1_1"/>
    <dbReference type="OMA" id="IYCCTPS"/>
    <dbReference type="OrthoDB" id="41492at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1780.10">
        <property type="entry name" value="ornithine cyclodeaminase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003462">
        <property type="entry name" value="ODC_Mu_crystall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023401">
        <property type="entry name" value="ODC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812">
        <property type="entry name" value="KETIMINE REDUCTASE MU-CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812:SF19">
        <property type="entry name" value="KETIMINE REDUCTASE MU-CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="89"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="414"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="414"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF13173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="488" mass="53303" checksum="CC0B3899E0B9BD10" modified="2013-05-01" version="1">MPLQILSNDDINKILHSFTKDDILALQETLADALHWYSTSSDGNNDCCSDYQPEQTTLKRKDGSTTVYLPASGITGQGVKVLNIAATSPEGTTNNNNNGRPLPVVMPSNASGGDSMTSTSSSSITTTSTSASQATTESMRNLSLRSKSEILDGTVAAPSSSTTSKGSLTLFDNEGNTVGLINAEEITAFRTALASTMLFEKRQSVHDVTIFGAGKQAYWHARLALLLRGEEIHHMNFVTHNFESAHHLLTKLYNPQPSDPTYINPIGTPYNSKTKKEILTPAHTEYTRLLKQYVRASNIIFCCTPNPSPNPLFPATYLTNPEGRKKGRYIACVGSYTSHMVELHPDVLRYAVAPHHEHRHVHKRQKEGGAILVDSVEACLKFAGEVVKAGLSPDQVVELGEIFMLKREREGIVKEGKAKGKGKKGEGDGEEEDDDGCHLQENSGLKEWLTRGNVIYKSVGLGLMDVVVGNELLRISRERGVGMTVEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M3CHM3</accession>
    <name>M3CHM3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_148638</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761409.1">
        <property type="nucleotide sequence ID" value="XM_016905047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CHM3"/>
    <dbReference type="STRING" id="692275.M3CHM3"/>
    <dbReference type="GeneID" id="27902184"/>
    <dbReference type="eggNOG" id="ENOG502S7DE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_169147_1_0_1"/>
    <dbReference type="OMA" id="YKAHTRL"/>
    <dbReference type="OrthoDB" id="5511599at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039297">
        <property type="entry name" value="COX7a"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02238">
        <property type="entry name" value="COX7a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF13288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="79" mass="9404" checksum="677BF1F118036851" modified="2013-05-01" version="1">MRATLIRRAGGMPQFPGMYRQNNVPAWQRLHQAHDGVRTWNKGPRAKYMLYPYYALMISTTAAAQYMMFRMVFGKKTWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M3CKB7</accession>
    <name>M3CKB7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_115510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762349.1">
        <property type="nucleotide sequence ID" value="XM_016901171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CKB7"/>
    <dbReference type="GeneID" id="27898308"/>
    <dbReference type="HOGENOM" id="CLU_2185593_0_0_1"/>
    <dbReference type="OrthoDB" id="3643896at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF14228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="109" mass="11646" checksum="FD4C1ED250E479BF" modified="2013-05-01" version="1">MAPAISKPASDAPQKPEESGTPYANLLKAQNRQPDAFDRAVMTWQAVTNGISKAGSSIAKLAKKAKNKRDGVPGESFPDPRLQGIGKPHENYDRTSTNESLQSLNGGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M3CL51</accession>
    <name>M3CL51_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CTP_transf_1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_148210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762639.1">
        <property type="nucleotide sequence ID" value="XM_016904776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CL51"/>
    <dbReference type="STRING" id="692275.M3CL51"/>
    <dbReference type="GeneID" id="27901913"/>
    <dbReference type="eggNOG" id="KOG4453">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031477_2_0_1"/>
    <dbReference type="OMA" id="NYWREMS"/>
    <dbReference type="OrthoDB" id="5673at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:ATP-dependent diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037997">
        <property type="entry name" value="Dgk1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31303">
        <property type="entry name" value="CTP-DEPENDENT DIACYLGLYCEROL KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31303:SF1">
        <property type="entry name" value="CTP-DEPENDENT DIACYLGLYCEROL KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01148">
        <property type="entry name" value="CTP_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="396"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF14518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="416" mass="45960" checksum="2B6703035A3B7BE3" modified="2013-05-01" version="1">MSSKGQIPNTPRVISPSPTPSETSGKEGYFPPTTRSKQRRVDASVAPIEEHANEGHNELGVQDETHPDFRRARSRSRSPQIQREALRMTANGGTTTAANTALPLSSVRTRGKSGEKVLSNGSAKQLIKENDLLSPASAVPQGFGSAYWRNLSRSPSPFGLIPVHREWRAFVHKHEIPRKALHVSIGFLTLFLYHQGFQTNQIHPVLLGLFIPIFSVDLIRFQWPEFNRVYIRYLGAFMRESEAHDRFNGVISYIGGLWLTMYFCRKDVAVVCVLLLSWCDTAASTFGRLWGKYTPRIRRGKSLAGSIAAFTFGVASAVLFWGVVAPKTPEEYNMGQHRFSFQGTLTLPKPAREYMNMSIGQATIGGHVALAVMSLVCGFVASFGEAIDLWGLDDNLTIPALCGLGLEVFLWAFGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M3CNP7</accession>
    <name>M3CNP7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_154226</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763509.1">
        <property type="nucleotide sequence ID" value="XM_016907555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CNP7"/>
    <dbReference type="STRING" id="692275.M3CNP7"/>
    <dbReference type="GeneID" id="27904692"/>
    <dbReference type="eggNOG" id="ENOG502RY03">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013364_5_2_1"/>
    <dbReference type="OMA" id="APCAFWK"/>
    <dbReference type="OrthoDB" id="425534at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF25">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032019" evidence="3">
        <location>
            <begin position="26"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S33 tripeptidyl aminopeptidase-like C-terminal" evidence="4">
        <location>
            <begin position="487"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF15388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="603" mass="66916" checksum="ED91093A7BFBC98E" modified="2013-05-01" version="1">MMMMVFLPLPLLLLASPYYISAVHALLPPFFLSAHHAGNASGRKSTFDWSSLTSDTELVYHSCYDDKFQCARLTVPLDWRDSSNPNNVSLPVIRLPATVPPSDPNHAGTVIVNPGGPGGPGTLWALENAEKLQTQLEGPRSYEILSFDPRGIFGSVPNGYCFDDAVQAEIWYDQKEAVGGLTSHPYALKFNWAAENARGELCAKTDIGKYPNGDNIRQFMSTASVARDVLEIIKKIESQKSSSQNSVATRRGDSQKPIDGDGAISVPKLQFFGTSYGTFIGQVFAAMYPEHVGRMVLDANLDAENWISRYEASTDDHLDIREYFYERCFLSKHECDFYREQDQGPEDVKARFHELLDLLDRVPAYATGSGRASPITSGDLLQGFMTTTYQPLLFFKAYAKFLSKLATQQNPGVPFWRRPVPTKEAFSDKMLAQEYLGGEVSPAVHCADGPEPFSGRSEQFTGFEKYLANLTDRFGSQVAGLQADFKIACWSWPDSLRTKWRYDGPFEGDVPILFVNNRLDPATPAKSAKKMAARYKGSVFLEQDAAGHGALFPPSMCIWEHVRSYMEKGELPPHGTVCDPKCIPFGQPCDGYDDSRLVVESVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M3CR09</accession>
    <name>M3CR09_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="8">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_131651</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF16108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764229.1">
        <property type="nucleotide sequence ID" value="XM_016902440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CR09"/>
    <dbReference type="STRING" id="692275.M3CR09"/>
    <dbReference type="ESTHER" id="sphms-m3cr09">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="GeneID" id="27899577"/>
    <dbReference type="eggNOG" id="KOG4389">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006586_10_6_1"/>
    <dbReference type="OMA" id="GCAGKAD"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000213">
        <property type="entry name" value="Carboxylic ester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012633020" description="Carboxylic ester hydrolase" evidence="9">
        <location>
            <begin position="16"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="10">
        <location>
            <begin position="26"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF16108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="589" mass="62915" checksum="B9F34754A6EA429E" modified="2013-05-01" version="1">MKTWIGLALGGLTWALPLDERQAAAPSATIRNGTVTGASSGGIDTFNGIPFAQPPVGNLRLKPPQPLVSGFPSGLRTFAATNAAAACPQFAFQVDNINLDSLPQDVISDVIGELINSPLGQTAINQKEDCLTINVQRPAGTAANAELPVIFWIFGGGFEAGWTAMYDGSNFVKQSVRLGKPVIYVAVNYRVGGFGFLAGKELAAEHSTNLGLRDQRLGLKWVQENIAAFGGDPAKVTIWGESAGAISVADHTIFEGGNIDYNGGKLFRAAIMNSGSLVPATDVSSPKAQNIYDQVVRSSSCAGNANTLACLRALPYNDFVRAVTSVPGIFSYRSLDLSYLPRPDPGDNFFPESPEVPVQAGRFAKVPVIIGDQEDEATLFSLVQSNITTNDDLVNYIASYFPSDPTNLATARGLASLYPNQPLLGQPAGSPFRTAAFNSIYPQFKRLAAILGDITFTLTRRTYLDVITTTAAVPAWSYLSTYLYGTPILGTFHASDIFLAAFGDAGISFPARSMQSYYIAFIHDLDPNGAGGGGGGGGGGGGELINWPKWNKEEPKLMNFELGRNSLMNDDFRSEVFEYLVTRLSTLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2022-12-14" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>M3CVY2</accession>
    <name>M3CVY2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_151990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756418.1">
        <property type="nucleotide sequence ID" value="XM_016907173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CVY2"/>
    <dbReference type="GeneID" id="27904310"/>
    <dbReference type="HOGENOM" id="CLU_1908004_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF08297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="133" mass="14989" checksum="D500A95E741B1845" modified="2013-05-01" version="1">MLRYGKISPRPGVLVRSALRAGDSHRGIPVWEVSFCGSSVMLARRCRLDANEIDRWWPCTRAHRKVAYCQICSSIVLHICACICATLRRRVSVERERERSVHRQPCGGGLLCCQISWYRKMIVGAGSGIMSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M3CWE3</accession>
    <name>M3CWE3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Vacuolar ATPase assembly protein VMA22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_15787</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF07986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756107.1">
        <property type="nucleotide sequence ID" value="XM_016907754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CWE3"/>
    <dbReference type="STRING" id="692275.M3CWE3"/>
    <dbReference type="GeneID" id="27904891"/>
    <dbReference type="eggNOG" id="ENOG502S6WS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057721_0_0_1"/>
    <dbReference type="OMA" id="GQDCYDE"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990871">
        <property type="term" value="C:Vma12-Vma22 assembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040357">
        <property type="entry name" value="Vma22/CCDC115"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31996">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31996:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21730">
        <property type="entry name" value="Vma22_CCDC115"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="81"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="125"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00093634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF07986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="228" mass="25244" checksum="E9AF83710E511AEF" modified="2013-05-01" version="1" fragment="single">QLDALWIQYLTLLDEYTKAQAAIQKHMSSGFFTLAQANFKSSRGRYGQDYYDERAVATTRIKIDAETDAISLKVEKFIVRTDEEQPSEDQSQEASSEHEMHGPNGQSQSEPVQLPSPAPTPGPESKQDPPVDSDAKDLPDAITPDTSTDPAPPESASQEKCKSLVNSHDPIRWFGILVPATLRQAQNSFVTAVRDGSTVTTAVNSSRGMREVEVEIRKLRKAIKKEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M3CXB1</accession>
    <name>M3CXB1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_144960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756427.1">
        <property type="nucleotide sequence ID" value="XM_016903087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CXB1"/>
    <dbReference type="STRING" id="692275.M3CXB1"/>
    <dbReference type="GeneID" id="27900224"/>
    <dbReference type="eggNOG" id="ENOG502S3RW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124044_0_0_1"/>
    <dbReference type="OrthoDB" id="3180714at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="28"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF08306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="146" mass="16652" checksum="73CAED97B4C8730D" modified="2013-05-01" version="1">MSPQKDDNHDHNNNIEKEQDTIHLQRFPHLYLALNTPKGRAVYPSSRIPRGTIIDTSPVLILSRQENTTHIAQTQLYHYTYNWPSTTTTNGQSSRGIPQQAVVLGLGSMFNHSTQNQNVGWKRDLERQVIVYTALKDIEVGEELSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M3CZU7</accession>
    <name>M3CZU7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_119885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758285.1">
        <property type="nucleotide sequence ID" value="XM_016901551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CZU7"/>
    <dbReference type="GeneID" id="27898688"/>
    <dbReference type="HOGENOM" id="CLU_004137_9_3_1"/>
    <dbReference type="OMA" id="MPVTETM"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF10164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="72" mass="7128" checksum="2A6035B4A63AD78C" modified="2013-05-01" version="1" fragment="single">MTATVTFTVTIMATVTFTATVTFTPTVPVTFPVAVAVTVAVTVTITVTATITATATITATATVTATATVTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>M3D0V7</accession>
    <name>M3D0V7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_110514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758244.1">
        <property type="nucleotide sequence ID" value="XM_016900848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D0V7"/>
    <dbReference type="GeneID" id="27897985"/>
    <dbReference type="HOGENOM" id="CLU_1099080_0_0_1"/>
    <dbReference type="OrthoDB" id="3646058at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032691" evidence="1">
        <location>
            <begin position="20"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF10123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="253" mass="27286" checksum="A9040C6899743F9A" modified="2013-05-01" version="1">MKACTIASLLALCATNAVASEASAAKRNAEPFMVLANPDGTLDEKSTAALLDWELRNQGGATLGRRDPFMVLANPDGTLDEKSTAALLDWELRNQGGATLGRRDPFMVLANPDGTLDEKSTAALLDWELRNQGGATLGRRDPFMVAANEDGTLDDESIAALLDWELRNQGKAQLTTRDAFTVAANPDGTLDDESIAALLDWELRNQGKAQLTTRDAFMVAANPDGSLTPESEAALRDWESRFGQKKRAMEFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M3D1H6</accession>
    <name>M3D1H6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD repeat-containing protein 36</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_68865</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759469.1">
        <property type="nucleotide sequence ID" value="XM_016909843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D1H6"/>
    <dbReference type="STRING" id="692275.M3D1H6"/>
    <dbReference type="GeneID" id="27906980"/>
    <dbReference type="eggNOG" id="KOG1539">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002774_1_0_1"/>
    <dbReference type="OMA" id="CIYAWRA"/>
    <dbReference type="OrthoDB" id="10250769at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059157">
        <property type="entry name" value="WDR36-Utp21_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007319">
        <property type="entry name" value="WDR36/Utp21_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22840">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22840:SF12">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25171">
        <property type="entry name" value="Beta-prop_WDR36-Utp21_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25168">
        <property type="entry name" value="Beta-prop_WDR36-Utp21_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04192">
        <property type="entry name" value="Utp21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDR36/Utp21 N-terminal" evidence="4">
        <location>
            <begin position="58"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="596"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="WDR36/Utp21 C-terminal" evidence="3">
        <location>
            <begin position="830"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF11348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1040" mass="113202" checksum="200F4B9A262FA3BA" modified="2013-05-01" version="1">MEVDGRVAKRQKLATGDARRHRPAGESRVFAPYRTVGLVSPTAVPFTSVALGKTTFQITTSVGRSLQTYDLRRGLNLVFITRPQTPEVITASVAWKDKLFAAWGGEGGASGRGVWVMKRGKKEAELEWPVDCEENVQAFCLLGSWIVGVCDTQLLVWKTSTLELYTSLRGISPVPFTGCVSGIPTFLNKIVAGRQDGSAEIWNVSSGKLVYTVLPPSTAYGAVTAIEPTPVLSLVAIAYERGPLLIHDIKTDQTAIQLNTPAGSPVTSISFRTDGLGAGEDGRLAGVMATASIASGDVTLWDLNNGGRKAGVLRAAHAQPTATTPGGTSRIEFLSGQAILVSSGLDNSLKTWIFDKTPFDPTPRILHELSGHGAPISKLMFLPTASDGADDDGKWLMSASKDRSLWGWSLRRDRQSTELSQGAVQKKAKKQGLLSGERDAFEDLKCPPITSMACGLNRDGGIGALPGKHPIWQNGQSKQVSAEVSAMTGWESVLTAHENDSKARTWFWGRKRAGRWAFATSDAGNVTSVAISPCGTFGLVGSDKGGIDMFNMQSGIQRQRFPARLTTMQAKQLRLDVDRDHFIVEDEGKKKFYRGQGKHAAAVVGLAVDSLNKTVVSAGADGKIKFWHFSSGLLKDQLDWSTSTGITGMRFHRGADLAAFACTDGCIRVIDISTQKLIRELWRSRTPLAELQDLKFSDFQFSTDGHWITASAGPLVFLWDLPTGHLVDVFKLRAECTTLALSPTGEYLATASNDNVGVDIWTNRSLFMHVSTRNITQKELLAVIQSSTAQAPTTSGEGGLNLIAGTAYESDSEDENIDLDISEDPNADLDSLSANLLSLSLVPRSRWQNLLHLDLIRERNKPTEAPKKPEKAPFFLPSLQDRQGQKAINANDSLGTSQADLEKERTRVLQLSRDGMRSQFTSLLRASGETEDFAPFLEHLKNLSPAATDVEIRSLSFEAAEHVSFVKSLTWLLQSKRDFELVQAWMAVFLRVHGDIVIGDQEVRDAVHEYKDALDGERKRVAKLAGYCSGLVGYLRAARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M3D1K8</accession>
    <name>M3D1K8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cyclododecanone monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_68932</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759504.1">
        <property type="nucleotide sequence ID" value="XM_016909845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D1K8"/>
    <dbReference type="GeneID" id="27906982"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006937_8_2_1"/>
    <dbReference type="OMA" id="ALKPWYG"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050775">
        <property type="entry name" value="FAD-binding_Monooxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098:SF4">
        <property type="entry name" value="BLR3857 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF11383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="579" mass="66228" checksum="CFBD0CDFF8C5C74A" modified="2013-05-01" version="1">MEAQKKYDAEREKRLAFGRDISQYRVVDGHFASWLGDPWKAETPREPVYRETDVLIMGGGYGSQLTAAELLKYGIQNFLMVDKCGGFGGTWWWNRYPGAQCDIESFIYMPLLEETGYVPTEKYAHQPELLEHAERIATHYGLHEKALFQTEILSIHWEEYKGVWRIITNHNDTIYARFVVLNSGPLHRPKLPGTPGIEKFKGHAFHSSRFDYEYCGKDLSKLQDKKVAIIGTGATAVQIIPHVAKNAKEFFVVQRTPSGVDTRLNCDTTEEWIKENIKPGWQKNRQHNFNKMSLGGATDEDLVDDNWSRVFLSFTNATKGAKPEDIPREILRKNFERMQSIRDRVDSTIQDPKVAEKLKPWYGWGCKRPTFHDGYLPSFNRPNVHLIDTDGKGIDEFTETGFKFNGVEYEVDAVIFATGYELATDWVQRAGMDVYGRSEPISKKWANGTIGLHSWGSNGFPNAFWITTAQGPLAVNALYGIHEQAIHLSYIINETLRRGAKCVEPSKEAEEAWLKEVLKAGQNRSTFEATCTPGWMNNEGHVTEKHVRNWWYGGNGLEYFKMIKDWRDAGKLEGLKVTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M3D2G4</accession>
    <name>M3D2G4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_88802</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-beta-lactamase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759453.1">
        <property type="nucleotide sequence ID" value="XM_016910484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D2G4"/>
    <dbReference type="STRING" id="692275.M3D2G4"/>
    <dbReference type="GeneID" id="27907621"/>
    <dbReference type="eggNOG" id="ENOG502S1A6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030571_1_0_1"/>
    <dbReference type="OMA" id="FYYVTES"/>
    <dbReference type="OrthoDB" id="10250730at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07730">
        <property type="entry name" value="metallo-hydrolase-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051013">
        <property type="entry name" value="MBL_superfamily_lactonases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978:SF5">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978">
        <property type="entry name" value="QUORUM-QUENCHING LACTONASE YTNP-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="5">
        <location>
            <begin position="56"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF11332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="398" mass="44588" checksum="D4AB93DD337F07DE" modified="2013-05-01" version="1">MSDNFLVPPKTPPELKIPASKNTVKVSCIDSTSRFKLPNSHFIQPDYTGHNTLNGPSFSFFIEPLSSSSSSSKPILFDLGIRKDWKLLPSATKLQNLHWEISVEKDVAEILRENKTNNNKIDIDGGGIASIIWSHHHWDHVGNAATFPSSTEIIVGPGFINAHLPGFPINPHSTILESDFFDAKDKTKRRNIREVDIQTLGKGFQIGRFYAWDFFDNGSFYLLDTPGHAIGHICGLARTTSDPDSFVFMGGDAAHHGGEFRPTEYLPLPRELGPPSPLPRKQPVCPGELLRGIHPYKKADQPFYYVTESFAQDKKLADWTIEGLGELDAQENILMLMAHDDAIVDPGQLDFYPRALNDWYRKGVKEKIKWLFLADFDEALAAKEKGGEPFKWVKDSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M3D4D1</accession>
    <name>M3D4D1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_148439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761181.1">
        <property type="nucleotide sequence ID" value="XM_016904930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D4D1"/>
    <dbReference type="STRING" id="692275.M3D4D1"/>
    <dbReference type="GeneID" id="27902067"/>
    <dbReference type="eggNOG" id="ENOG502QSKG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010595_0_0_1"/>
    <dbReference type="OMA" id="MCADEDP"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF13060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="508" mass="56412" checksum="2B0267B0D8BCFCD1" modified="2013-05-01" version="1">MADQINNNNHHHHHHHHNNNNHNHNQPPAIAANSSAKRAPPTNEAEERLAIERELAAKLKGTRDYLSTLSTEATPCSSEQQQDIRATTLSHGHSETATGSADASRSAAPLTEPIHPNRGDHGTPAGSVAAAPAAAPPPLPPPAAAPPASSPSSSSMAAPDASSSLPPGDAAMLDGGQNAEEQRLEPDELDSDSALGSDTESRTTSLSESIYNYRREHGRTYHAYKDGKYIFPNDEREAERLDLQHHLLRITYANKLYFAPLHRPRRCLDVGTGTGIWAIDFADEFPDCMVTGIDLSPGQPNLVPPNVKFVVDDAEDLWLYEEKFDYIHVRLMSGCFSDWPAFMRQAYDNLEPGGWLELQDYGLPVKSADGTHLGTDMLRWGELLLEAGRVIGRPLGSDVSEHFEEWMQQVGFVDIQHKMFMWPSSSWPKDPFMKELGRWNQVNIIDGLEAFCLALLTRGLGWSKTEVDVFVARISNDFRNKRIHAYFPMPVVWARKPFPGEIPFSQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M3D4D2</accession>
    <name>M3D4D2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SCF ubiquitin ligase subunit CulC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_149321</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760870.1">
        <property type="nucleotide sequence ID" value="XM_016905488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D4D2"/>
    <dbReference type="STRING" id="692275.M3D4D2"/>
    <dbReference type="GeneID" id="27902625"/>
    <dbReference type="eggNOG" id="KOG2166">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004747_7_1_1"/>
    <dbReference type="OMA" id="MFKDMTI"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000001">
        <property type="entry name" value="Cullin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000002">
        <property type="entry name" value="cullin-3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000061">
        <property type="entry name" value="Related to cullulin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000036">
        <property type="entry name" value="SCF ubiquitin ligase subunit CulC, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.130:FF:000011">
        <property type="entry name" value="SCF ubiquitin ligase subunit CulC, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Cullin family profile" evidence="7">
        <location>
            <begin position="443"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="361"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="363"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF12749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="823" mass="93993" checksum="377A9A5F5D571881" modified="2013-05-01" version="1">MASLAGRGRAKIRAPRRTLHGADVDFEATWQVLERAFTEIHEKNASALSFEELYRNAYKLVLKKKGTDLYDKVAQFEEHWLGDGVRPRIVNLLTAPLQLTDDLGRSLATTSERRVAGERFLASLKLAWEDHQVCMGMLTDVLMYMDRVYCTDNRQPSIFAKSMSIFRDQILRTPIRSGADDLLQYLTNLILDQISMDREGESIDSSLIKSNIYMLEGLYESQQEIEEEKLYIKSFEADFLERSARFYREEGERLLTEADAGTYCKHAKRRIDEESDRCRSTLSESTAPKIQKVVEDELIRHKMKGLIEMDSGVRYMIDNDKYNELHLLYDLEARVDPKKPELTKAVQVIVAEMGAKINEDAHTATSAPPAPATSAEDGEVEKTKGGSPKQINQQTIAALKWVEEILALKDRFDTVWKVSFNSDQSISTALTRSMSDNINAFARASEYISLFIDDNMKKGIKDKTDEEVDRILEKAIVLLRYLQDKDIFENYYKKHLCKRLLLKKSHDPDVETSMISRMKMELGNSFTMKLEAMFKDMRISKDLTDNYRRKVAGLGDGDRSRVDLTVNVLTSMTWPLEAFRSSSEDDIENKAQIIYPASLDRVRRGFEAFYSEKHSGRKLTWQTSMGDVDVRARFPRSNKIHEVNCSTYAALILVLFNDLASGDTLSLEEIQSKTNIPMNALKRNLQSLAVAPKTRLLSKEPMGREINAGDKFGFNEQFKPTAIKIKVGVVSAGNKVEGDKERKETEKKNNDSRGYVIEAAIVRIMKQRKELAHAQLLTETLTVCSAQFKPDVNMIKKRIESLIERDYLERLEDAPVASYKYMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2022-12-14" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>M3D4P0</accession>
    <name>M3D4P0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_125914</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760960.1">
        <property type="nucleotide sequence ID" value="XM_016902021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D4P0"/>
    <dbReference type="GeneID" id="27899158"/>
    <dbReference type="HOGENOM" id="CLU_2564801_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF12839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="82" mass="9119" checksum="A3AC6754CCE466E1" modified="2013-05-01" version="1" fragment="single">MTVLYTVHNDHSYGTLYSQLPYSFTYCAGALGERAGRPREFAGVFMGARQIKTRGNRRSSPHTVPASERVVFCVKCGESQLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M3D5U9</accession>
    <name>M3D5U9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Homoserine O-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_64008</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761375.1">
        <property type="nucleotide sequence ID" value="XM_016909665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D5U9"/>
    <dbReference type="STRING" id="692275.M3D5U9"/>
    <dbReference type="GeneID" id="27906802"/>
    <dbReference type="eggNOG" id="ENOG502QR3J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028760_7_0_1"/>
    <dbReference type="OMA" id="HPILVMG"/>
    <dbReference type="OrthoDB" id="444135at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009001">
        <property type="term" value="F:serine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009092">
        <property type="term" value="P:homoserine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00296">
        <property type="entry name" value="MetX_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01392">
        <property type="entry name" value="homoserO_Ac_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001209">
        <property type="entry name" value="PRK00175.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268:SF16">
        <property type="entry name" value="SERINE O-SUCCINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000443">
        <property type="entry name" value="Homoser_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="139"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="421"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="435"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF13254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="530" mass="57963" checksum="73C6A3B7BCF81E9C" modified="2013-05-01" version="1">MSVPRALRCLTRPQWHHDVGRIVQVPRNPRTPIRTIHHQKPAAAQAFANQPIQEDLPAGPSISNPQQLSFPCLDNAEDRTRQLSNKKRSLSGPEPSYTSGKHETFHSDAPILLDWGGVLPSYDIAWEAWGTLNADKSNAILLHTGLSASSHAHSTEANPKPGWWEKFIGPGAPLDTEKYFVICTNVIGGCYGSTGPSSVNPATGEHYGTSFPILTMQDMVRAQLALLDAMGIQKLYASVGNSMGGMQSLALGVLNNERVGRIVSVSGCARSTPSSVAMRHCQRQVLMNDPAWAKTRGNYYNSIPPHTGMKLAREIATITYRSGPEWEKRFGRQRADPSKPPALCPDFLIETYLDHAGEKWCLEYDANSLLYVSKAMDLFDLGKELQDATANRRAENAGKLEHGFKEAQAQQDRCALSIPDEPYEEQESSAEIMAASTSDPAARGPSTSGPPEDLVRGLAPLRDIPTLVVGVASDILFPAWQQREIADALRRVGNRSVSHAELGEDRSLFGHDTFLLDLEGVGGEIKRFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M3D6H0</accession>
    <name>M3D6H0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Coatomer subunit beta'</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SEPMUDRAFT_148961</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasmic vesicle</location>
            <location evidence="1 13">COPI-coated vesicle membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Golgi apparatus membrane</location>
            <topology evidence="13">Peripheral membrane protein</topology>
            <orientation evidence="13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="13">The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the WD repeat COPB2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761891.1">
        <property type="nucleotide sequence ID" value="XM_016905255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D6H0"/>
    <dbReference type="STRING" id="692275.M3D6H0"/>
    <dbReference type="GeneID" id="27902392"/>
    <dbReference type="eggNOG" id="KOG0276">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005507_1_0_1"/>
    <dbReference type="OMA" id="YVDYYPQ"/>
    <dbReference type="OrthoDB" id="10261470at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008298">
        <property type="term" value="P:intracellular mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd22947">
        <property type="entry name" value="Coatomer_WDAD_beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000016">
        <property type="entry name" value="Coatomer alpha subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000001">
        <property type="entry name" value="Coatomer subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006692">
        <property type="entry name" value="Beta-prop_COPA/B_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050844">
        <property type="entry name" value="Coatomer_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016453">
        <property type="entry name" value="COPB2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056176">
        <property type="entry name" value="TPR_COPA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876">
        <property type="entry name" value="COATOMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876:SF2">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04053">
        <property type="entry name" value="B-prop_COPA_B_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23953">
        <property type="entry name" value="TPR_COPA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005567">
        <property type="entry name" value="Coatomer_beta'_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 13" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <keyword evidence="5 14" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="9"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="93"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="136"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="180"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="224"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B second beta-propeller" evidence="16">
        <location>
            <begin position="318"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B TPR" evidence="17">
        <location>
            <begin position="596"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="817"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="827"/>
            <end position="857"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF23953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMF13770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="857" mass="95688" checksum="7010C2FC6FAB2952" modified="2013-05-01" version="1">MKLDVKRQLFARSERVKGIDFHPTEPWILTTLYSGHVYIWSYETQSIVKTFELADVPVRAGRFIARKNWIVCGSDDFQLRVYNYNTSEKITSFEAHPDYIRAIVVHPSQPFVLTASDDMTIKLWDWDKGWQCVQVFEGHNHYVMGLAINPKDTNTFASACLDRTVKIWSLGSRTANYTLEAHETKGVNHVDYYPQSDKPYLLTTSDDRTVKIWDYTTKALIATLEGHTSNVSFACYHPELPVIISGSEDGTVKIWHANTYRLEQSLSYGLERAWCVSYQRGKQGIAMGFDDGAVVVKMGREEPAVSMDGSGKIIWARHSEILTSVIKGGDKSVKDAQPISLPSKDLGSTEIYPQTLLHSPNGRFVAVCGDGEYIIYTALALRNQAFGSALDFAWASKDNDKDYAIRESQYSVKIYRNFKPKGGDGTVNVGYTADGLSGGVLLGIKGQGGIGFFDWETGKLVRRIEVEPKNVYWSESGELVALACEDTFYVLRYSREQYVAAVQSGAVEDDGVEDAFEVVCDINESVRTGQWVGDCFVYTNSTNRLNYLVGDQTYTVSHFDQPYYVLGYLTRDGRVYVCDKDVNVISFALSVSVIEFQTLVLRGELESAMAMLEEGEIPEEQKTKIARFLEGQNYNEEALQVSTDNEHRFELALGLGELDIALDLARQADVEHKWKTVGDAALARFNIALAEECFRSAKDLSSLLLLYTSSASEDGLRWVASKAQEVGQHNVAFTCLWSVGDVDACLDLLIKTDRLAEAVQTAHTYKPSRLLEIVGLWKASLEKIGKGKVARLIGSPDQDPDMFPNFEESLRLEQEGGGHADLIDVNGGEEETQATAEADQEEVEAEQEVEPEAEAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M3D848</accession>
    <name>M3D848_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EKC/KEOPS complex subunit CGI121</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">EKC/KEOPS complex subunit cgi121</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_148073</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. CGI121 acts as an allosteric effector that regulates the t(6)A activity of the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators. CGI121 is not required for tRNA modification.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the CGI121/TPRKB family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762446.1">
        <property type="nucleotide sequence ID" value="XM_016904683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D848"/>
    <dbReference type="STRING" id="692275.M3D848"/>
    <dbReference type="GeneID" id="27901820"/>
    <dbReference type="eggNOG" id="KOG4066">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065847_1_0_1"/>
    <dbReference type="OMA" id="IVCRMST"/>
    <dbReference type="OrthoDB" id="329139at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2380.10">
        <property type="entry name" value="CGI121/TPRKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013926">
        <property type="entry name" value="CGI121/TPRKB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036504">
        <property type="entry name" value="CGI121/TPRKB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15840">
        <property type="entry name" value="CGI-121 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15840:SF10">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT TPRKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08617">
        <property type="entry name" value="CGI-121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143870">
        <property type="entry name" value="PF0523-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF14325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="181" mass="19993" checksum="571533D0DF327FDF" modified="2013-05-01" version="1">METISLPHLPDHPLHVALFADVQNAPFLRKQLLDGNTDFQYAFLDASVLLSRTHVLSACWRAINDQLADRMKSHNVHSEIVFAMSPNNNIGESFRRFGVQDESKNIVAIKVAGDRSAVEQHLLQNVEGKPTKLSDEALATIHDAGRIRKIYRLDAPKKGEAVQLGKEAEAFVIGSMALKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M3D8D6</accession>
    <name>M3D8D6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_147951</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762265.1">
        <property type="nucleotide sequence ID" value="XM_016904618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D8D6"/>
    <dbReference type="STRING" id="692275.M3D8D6"/>
    <dbReference type="GeneID" id="27901755"/>
    <dbReference type="eggNOG" id="KOG0519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012737_0_0_1"/>
    <dbReference type="OMA" id="ETTHEMK"/>
    <dbReference type="OrthoDB" id="21225at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF72">
        <property type="entry name" value="OSMOSENSING HISTIDINE PROTEIN KINASE SLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="412"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="817"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="870"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF14144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="950" mass="104453" checksum="7B5673E7D3054CAB" modified="2013-05-01" version="1">MLAGAFYPRADTGFGYGPRDGSLPRRPQTVEPILDAASLLEPLTSFNENLHHQIYASEPSDDGTSKPPPKPEGFSDPYLYPMLTRNERLRLTMLWYYTRDLLGDEDLLKKMQAKVDLLASIIGWDFAICGLIDNDIFERLSTTGLPLARLPRRESTCSHTVLQQPSSSVFFIPDLSDDWRFKESPHVSQGGLRTYAGAQLRCRVDGNDQDLALGSVCVASNTPGLALKPSQLEIIVKFADMLTEDIINGSRRKRAKQQELNDALLQEAFAESFKNPTEAAVLRILGQAFPKAQLSLLPVEGGRVQLQNGPSVEVPDVHVKSTTWEDHDLIEQLLRNHNHERLSATQPVRAIIGTFPSNAVNTALVVSTTDITFIFDDVDVRFVEGCAMILRSVGQERSLQEALKTRERFLRGITHQLRTPIHGILGSVDLLVDELSKSRRNRLASAPTDHRVPENLRMIQSSGRELMSTVNNVIKFNRWTDSVRTSKTATLGALDTLESEILEEISSLLPSDQSDRMSILFCNQLPAEVGAVQIDTIVVKDCLQSLILNAVQNTEQGSVVISTSMASDRSTIIFDVHDTGCGIPVSDQSRIFDAYEKGNAHSTGAGLGLTLAYNIANALDGAVTLVSSVPGVGSHFQAQFREPSFACSMDGARAVVKESVLPSRFAILSSSNPVSTFDEHLAHVLETRGLELTKDIADALVVVPFHNQQYEDLLHQAAQCPATISLVPAGQDVSKYQKSYPGIMFFSGPFTSKRLEEIIVATRSTCMARRSSSSKVQHTADSEVSIEARPVAQRYDSVAPEHLSRLNAMTLNAATPNCLIVDDNVINLRIMKMYCETRKFPYTTAVDGLQAVYKYKEAVAGIPINLILLDLQMPNCDGIEACEQIRDFEAKEGLSPAAIFIVTGQDSPTDRTKSFEAGADKFFVKPLALKSLDRGIADVFDDNMKSAPDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M3D8N6</accession>
    <name>M3D8N6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_148187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762611.1">
        <property type="nucleotide sequence ID" value="XM_016904762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D8N6"/>
    <dbReference type="STRING" id="692275.M3D8N6"/>
    <dbReference type="GeneID" id="27901899"/>
    <dbReference type="eggNOG" id="ENOG502SPQT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098340_0_0_1"/>
    <dbReference type="OMA" id="PWFEEMI"/>
    <dbReference type="OrthoDB" id="3907216at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF14490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="271" mass="30168" checksum="B59FF0D120C27F76" modified="2013-05-01" version="1">MADERHHQLQQQQQLHGSCSCERFRYVINVRPESSNLARVFFDNSSASRRAQAAPLAAWLRIPFDWYHSTTYAYYDNESHSSIKKTYHTPSPPHSLLPPTRRQFCGYCGTTLTAWNEGTHASGHGSTSSDYLDVTLGSLLDESLDQLEALRILPADVDSDESEGELQGTAAGMRDTSLEELPSACASVPRTLSQAGESHSIHRMSDRGMPFFEELIENSRLGRIRRQRGGQTARDGSSTIQWEVIETIIGSDESPTSTGHASSPNKRQRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M3D9C1</accession>
    <name>M3D9C1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_40633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762851.1">
        <property type="nucleotide sequence ID" value="XM_016908792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D9C1"/>
    <dbReference type="GeneID" id="27905929"/>
    <dbReference type="HOGENOM" id="CLU_2644873_0_0_1"/>
    <dbReference type="OrthoDB" id="3863715at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCHC-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="1">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="1">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF14730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="77" mass="8479" checksum="2869B043ADA2F00F" modified="2013-05-01" version="1" fragment="single">MTSPLSTSQPYCKYCNSTAHTTEVCTNTANWTAYQPSRLKCSRCTLRGHTSNSCNNPAGKDCAYCLAPGHERMECPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M3D9L4</accession>
    <name>M3D9L4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_148239</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762685.1">
        <property type="nucleotide sequence ID" value="XM_016904794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D9L4"/>
    <dbReference type="GeneID" id="27901931"/>
    <dbReference type="eggNOG" id="ENOG502QTPC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016203_0_0_1"/>
    <dbReference type="OMA" id="NNLRTHA"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF18">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="2">
        <location>
            <begin position="59"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF14564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="454" mass="50517" checksum="109C209538783DB5" modified="2013-05-01" version="1">MAVCALVSARVRDGAVFSPRWDVSSLREPPPDIYYKEAIWQLGSETAVGDINNLRTHAILALAAIQDGKVRDMHEHLGRYHTIVAAGGLHDEVNWPKNIGIVEKEERRRLFWSVYTLDIFTSIVWGGVIRSREYQSSVSYPTEADDDMFDDAGFASITVPNGQPDTSPGALHSDSGAISWIAGRNIVIDLYRVLEHIMMRLCARNSRAQRQTLIDEVLHASDSLSQEAVLASVMQMHANLPQCFKTTNPITSKPRLDRFGFQAADIIATVQLLRMVLLSATGASIAEKCQIANEVVSAFIAIPTAYHHAISVPLLFHLGVIGQILATTLGQTLSEIDYNNIRGVMMAMIQLLSSLEGLHASKGASQRLRDQITRIDEYMTLQRHRTSKVQHIRSEATNSMPRPEPETVYATTLSPYSSRAMDENMDLSPFQLPSEILGDLDQIFDFSQVPWNMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M3D9W3</accession>
    <name>M3D9W3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_148314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762795.1">
        <property type="nucleotide sequence ID" value="XM_016904844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D9W3"/>
    <dbReference type="STRING" id="692275.M3D9W3"/>
    <dbReference type="GeneID" id="27901981"/>
    <dbReference type="eggNOG" id="ENOG502S5YD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_340639_0_0_1"/>
    <dbReference type="OMA" id="KYGVENR"/>
    <dbReference type="OrthoDB" id="2587563at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2670">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042065">
        <property type="entry name" value="E3_ELL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <begin position="318"/>
            <end position="724"/>
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        <location>
            <begin position="169"/>
            <end position="182"/>
        </location>
    </feature>
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            <begin position="372"/>
            <end position="398"/>
        </location>
    </feature>
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            <begin position="436"/>
            <end position="483"/>
        </location>
    </feature>
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            <begin position="511"/>
            <end position="530"/>
        </location>
    </feature>
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            <end position="656"/>
        </location>
    </feature>
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            <begin position="690"/>
            <end position="705"/>
        </location>
    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF14674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="792" mass="83571" checksum="5BD4263038161A69" modified="2013-05-01" version="1">MSVTAMPASGLTLHGIPRGDAGPKQSATPAVLFKLSEDLLEDVKKSSAASGGLSFVNGTTPRIRLGTRSIDLTISPEAFKHELFSAATGSLTDLTFAGAVGLRAELKVPTRKQSLGADAALAALQNSLASYHQEKAAKSVTVTNSLIGTPKNRFEANRDQKYAHRRGLSGSQHASPSLSASDTPRPGAALTSVPSNDPALRLKAMRKPLIHLLAIEPLVPEEITQRTHIPKADVEEILSKIGKPAEGKKMGLTDRAFKELDVYSFGYSTPEERQAAIDNAVRAYDRQRIGKEEKIWQMLLPEDRRNKGEYLSKLHIGAPTNVGASPMLAGDGDDRTGGSSVAGTPRLGAGTPKVASAKSDLMKKLAKNPKQRAIEDAKDKKRKEREAAKADSDKESRPVKRARTAAATTAKNNPKIKSAELVQSSSEDEAGGGGDVSSSTTTQPAKAAAATKRAPVTNAAAKPKPKPKAMAASASASASTSSADVPDKRVPLKSAASRAAATNPVVAKPSKAGTPAARSSAAAAAAARSKPAPPGKRTPNGLHAPAPQQRSQLSPNPAKPNHRPTAPSPLGAARPRVASDVSMQRGRPGADTPKGLGISNADGIRRRHDTITSNSSSNSDKPGVGLGKSATNSHARHSASMNGNAGTGRDVSSTASGPKHKHENGIKRKAMDTPQDEDGIATTKHRKTESSSSHSQNSISAGSSNSDHDRPNFITSPSAGGRMSFAQGVNLARKFRDEWYPAYVKLFDELEAIQRRGERLPPADKERLLHMHERLLQVKREIADASQREHET</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M3DA66</accession>
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            <fullName evidence="2">FHA domain-containing protein</fullName>
        </recommendedName>
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    <organism evidence="3 4">
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        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
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        <lineage>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016904006.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="116"/>
            <end position="169"/>
        </location>
    </feature>
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            <begin position="1"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="7"/>
            <end position="17"/>
        </location>
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        </location>
    </feature>
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            <begin position="308"/>
            <end position="319"/>
        </location>
    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMF14975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="512" mass="56684" checksum="E5D01C41A12CD5AD" modified="2013-05-01" version="1">MEAATRAGNQAVPSPETNEAPPARPSLLPAFEPFSSPFSSSPGLPRAVKRKFDETLDTRQQHYPTPVPTSSTGILTSSSPASRTRPALKRTVSALSERAPLGDVPCLVLPRNGEPLLMGRSSNSSDYQFPANRHISRTHVSATYYAPDETYPHGRVEVECLGWNGAKVHCRGEMRELAKHEVFVSDKAMAHIMVDVQSTRVMLAWPQEHARDPPAESRSQWPQDSPIQSRLASAHVPSSPPIMLPSPRPATPVSPTPNYNLGTSFSETFRVDTDEPVHVYQDHDSEEDALHDTETTPEPMAPVCEGTPTPTRTVSSPQEPSRLASEHEDFSEHDEENDPVVHSFGPFGANLLDKLDSFHAESPERKRKPLKATTNSPRRSAPTPASHISPVKNHVINQLAYSRIHALPLSTIHSQLPPEYRGAMAKPSDREAREVLSTSDLKTILDDIPCVGEISREGKDAAGKLLESEFYYVPEMDSDVHRRDAVANSLGKTSIRAARKQHKQYYWKRPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M3DAE8</accession>
    <name>M3DAE8_SPHMS</name>
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        <submittedName>
            <fullName evidence="9">RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_148424</name>
    </gene>
    <organism evidence="9 10">
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        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="EMF14844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="692275.M3DAE8"/>
    <dbReference type="GeneID" id="27902057"/>
    <dbReference type="eggNOG" id="KOG0130">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_18_0_1"/>
    <dbReference type="OMA" id="ESEMQTH"/>
    <dbReference type="OrthoDB" id="15688at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008111">
        <property type="entry name" value="RNA-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033744">
        <property type="entry name" value="RRM_RBM8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45894">
        <property type="entry name" value="RNA-BINDING PROTEIN 8A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01738">
        <property type="entry name" value="RNABINDINGM8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="55"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="132"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF14844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="169" mass="18592" checksum="62BDFCBB7DC1CAB7" modified="2013-05-01" version="1">MADSEMADAPQASSLHHDDHDEEVLEDAKPPASKSASTDTRTAENAAAVRSIEGWIIIVTNVHEEASEEDIQDMFGEYGDIKNLHMNLDRRTGYVKGYVLIEYPTLDEAKAAIQDADGKELLEQTIGVDYAFVRPPPSKGAPPKGQRKGGRERSASPGARRRKDEDDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2022-12-14" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>M3DBB6</accession>
    <name>M3DBB6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_147110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763265.1">
        <property type="nucleotide sequence ID" value="XM_016904086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DBB6"/>
    <dbReference type="GeneID" id="27901223"/>
    <dbReference type="HOGENOM" id="CLU_2962382_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF15144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="59" mass="6806" checksum="F6B9CD3AF154D962" modified="2013-05-01" version="1">MYLHRYRYSPNPVQVSRKKHKTVEYSRLSAPSGATRTSYLIALLYVNGMGSTLPTSYYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M3DBN2</accession>
    <name>M3DBN2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Enolase C-terminal domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_147345</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763581.1">
        <property type="nucleotide sequence ID" value="XM_016904239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DBN2"/>
    <dbReference type="STRING" id="692275.M3DBN2"/>
    <dbReference type="GeneID" id="27901376"/>
    <dbReference type="eggNOG" id="ENOG502QRWW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030273_3_2_1"/>
    <dbReference type="OMA" id="EYMRHTE"/>
    <dbReference type="OrthoDB" id="2579025at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008869">
        <property type="term" value="F:galactonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034194">
        <property type="term" value="P:D-galactonate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03325">
        <property type="entry name" value="D-galactonate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034593">
        <property type="entry name" value="DgoD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023592">
        <property type="entry name" value="Galactonate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018110">
        <property type="entry name" value="Mandel_Rmase/mucon_lact_enz_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010624">
        <property type="entry name" value="PRK14017.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080:SF2">
        <property type="entry name" value="D-GALACTONATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080">
        <property type="entry name" value="D-GALACTONATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00003">
        <property type="entry name" value="D-galactonate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00179">
        <property type="entry name" value="mandelate_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00908">
        <property type="entry name" value="MR_MLE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mandelate racemase/muconate lactonizing enzyme C-terminal" evidence="5">
        <location>
            <begin position="125"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF15460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="380" mass="41987" checksum="213F8CE4E57949FD" modified="2013-05-01" version="1">MLIASIEYFRLPPRWLFVKLVDAAGNVGWGEASLEGHTEAVEGCLDAFGERFVGQEADDIEQIWQLGYRMGFYRGGPVIMSALSGVDIALWDLKARKLNLPIYQLLGGKVRDQLKVYAWIGGDRPHDVEAMARGRLEAGFRAVKMNATEDLGWLDSPSTLDACLERVKVVRRLGLDAGVDFHGRVHKPMAKQLAKLLEPERLLFIEEPLLSENIEGIQELSQHVSTPIALGERLHSRWDVKRFLEARCVDVLQPDICHCGGISECFRIAKMAEAYDVALAPHCPLGPIALAASVHIDATSSNFAIQEMPLGIHYNVGGSDLTSYHTNPEVWQVTDGYIQLMTGPGLGIDIDEAAVRAASVQTKAWRSPHFVGPGGEIREW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M3DCJ4</accession>
    <name>M3DCJ4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Atos-like conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_147555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763881.1">
        <property type="nucleotide sequence ID" value="XM_016904377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DCJ4"/>
    <dbReference type="STRING" id="692275.M3DCJ4"/>
    <dbReference type="GeneID" id="27901514"/>
    <dbReference type="eggNOG" id="KOG2306">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010290_0_0_1"/>
    <dbReference type="OMA" id="SPVAPWH"/>
    <dbReference type="OrthoDB" id="8625101at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033473">
        <property type="entry name" value="Atos-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025261">
        <property type="entry name" value="Atos-like_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051506">
        <property type="entry name" value="ATOS_Transcription_Regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13199">
        <property type="entry name" value="GH03947P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13199:SF11">
        <property type="entry name" value="PROTEIN ATOSSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13889">
        <property type="entry name" value="Chromosome_seg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13915">
        <property type="entry name" value="DUF4210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01177">
        <property type="entry name" value="DUF4210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Atos-like conserved" evidence="2">
        <location>
            <begin position="355"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="624"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="668"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="668"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="698"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="737"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF15760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="786" mass="87261" checksum="BA7E55614FD91579" modified="2013-05-01" version="1">MAVNNGYPGSQTAFGQQSSTGHNEHEANSPTKSRAVSPETGRSSPTIYNPYYTGRPRTPANGVKTSMIDRQELIRRIKSGSRPSSPELEKPPSSEYSRLAKIKSKEARPASPELERPTSNGLEGKWKSPVPFQGPPAVQDAKPQSPEIQQDNQAAGLKIERPRSALHRGDFREQTTPDRFGGRTTLSQEQQCVLSTSPVVPWHPAFPATYRQSHKDKRATHAETSSIPIPRPERPRTVSNASLAASFVYKPPTSPLVQSSRPDTPEPPLRNHSRSPDKSRRHTFSPRSFHHLQSSLDYPTTARIAPALRPEKTFPYQAHQPRRSVNPSSPFTSQSPVAGQRRPSITDSPLHHAPLVGSYEESILRGRMSTTPSKPLNFVAQIGVLGKGECKPNLRCPPHVQIPFPAVFYSYGGASKTPALDQPSPYVGLVDLENNLPNNEQVRDRRRDRMRATTNSDAGSRANSPGGSGSDATRRRRRTKQKRRSGSPKAPPGGSYRIPQQGQLQIVLKNPNKTAVKLFLVPYDLSDMEAGQKTFIRQRSYSAGPIIDMPLSSRTNYGTDRPEASLNPTGDVNDKPVLRYLIHLHICCPSKGRYFLYKSVRVVFANRVPDGKEKLLSEVQLPEPRFSSYKPGKEAKPGSTTTTPAKDELRRRSALDPAIAGCRWSSSTDFAQSMPTSEHLTQQQYDAPTPTLPRHFTTLPTLQSRPASRSFSDNMDVDSGSQGTRSPMSPTSTQGDEMTRSMPRLDDPFVFERDRSRERRSGKNGNESLLSKRLMDLAFQKQQELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M3DED5</accession>
    <name>M3DED5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_124240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF16160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764281.1">
        <property type="nucleotide sequence ID" value="XM_016901899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DED5"/>
    <dbReference type="GeneID" id="27899036"/>
    <dbReference type="HOGENOM" id="CLU_2470504_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF16160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="88" mass="9865" checksum="FCACCBF9C4C616D1" modified="2013-05-01" version="1">MMADGARTGNPVWITKEEQEEKEEEEEDQRIGRYDTYDMQTRASRVGNKHGMNEASPTTGAMSPQRSDATSDSASYSLSTMRKTSLIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDG9</accession>
    <name>N1QDG9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_151464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757562.1">
        <property type="nucleotide sequence ID" value="XM_016906834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QDG9"/>
    <dbReference type="GeneID" id="27903971"/>
    <dbReference type="eggNOG" id="ENOG502RQGU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1435249_0_0_1"/>
    <dbReference type="OMA" id="GEASWCK"/>
    <dbReference type="OrthoDB" id="62952at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="4"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="189" mass="21752" checksum="1FBA78734F84175F" modified="2013-06-26" version="1">MVGFLDLPLELRNRIYEYDVPHNQVIPLSQVVDRVQSTNNDLLLEDHEPVFPQLPVYAGVSRQVRAEALSIYYGSNIFTANSMLDTSNFLQRLDSQSLTRIREIRATTCQHSAIKQLVKPKLEKLVTHSAMGLLSRNAAKVPLRTKRTGRGSSDGDFEMTWVSLAELHLWERDPRDIDMVRRVTWLSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDL9</accession>
    <name>N1QDL9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_151540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757687.1">
        <property type="nucleotide sequence ID" value="XM_016906879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QDL9"/>
    <dbReference type="GeneID" id="27904016"/>
    <dbReference type="HOGENOM" id="CLU_1176046_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="236" mass="27658" checksum="1CE6A5D8223BD25A" modified="2013-06-26" version="1">MDLLSRHSVGLSRMWHLEADSEPRWTSCWNSTNIARRTNRDALWLDQTMIPQLLRIWWQPLLVQWLFIHLSQITSLASPWPTVSLAGYYRIITSPQVFYVAANLREQARVSLSSLPDGRYIPPRCWTCFASSVTSISHPRSFRQNATHTHSTREFHLLQHHLQYSLSNHPNTKKPTSNQNHAFLQGNRRRRHGLLRSRYANASLWPEPYHQLARTTRRPNEGMQGFPNVPYDEEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDN2</accession>
    <name>N1QDN2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_166257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757721.1">
        <property type="nucleotide sequence ID" value="XM_016908215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QDN2"/>
    <dbReference type="GeneID" id="27905352"/>
    <dbReference type="eggNOG" id="ENOG502SNB9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061423_0_0_1"/>
    <dbReference type="OMA" id="WEIAGYF"/>
    <dbReference type="OrthoDB" id="5404599at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF58">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="96"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="316" mass="35848" checksum="01FFDB5489B0CE27" modified="2013-06-26" version="1">MLLDSIDPVRESLKEVAVNLWTIADHLFLYRQSVQPPDCTSWKDGHGGFFVLSDAKPPTLESLSPIPPIPLVYDVGDSHAVWEMGDAFLKVLIPLSPDTTREHVTLEALHQMNLSFTLPKVLYHGEWNERYYLVVSKIPGQTLSKAWPYMSETCRDQCVDGVVSICKELAATHAEQITGIDGNHVPEQWLADNSPRSPSGTPPKYEFDFRPETFLKNCREVEGMDCSLPFQFYHCDLGPGNIIVDFVADQVVVGVIDWECAGFFPRHWIRTKFRMCSSMDLPEGDTSDWRARMQRKLGEEGFPEVAEAWMVWRGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDV6</accession>
    <name>N1QDV6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">O-methylsterigmatocystin oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_143070</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758492.1">
        <property type="nucleotide sequence ID" value="XM_016903023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QDV6"/>
    <dbReference type="STRING" id="692275.N1QDV6"/>
    <dbReference type="GeneID" id="27900160"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_2_1_1"/>
    <dbReference type="OMA" id="AKWEIFL"/>
    <dbReference type="OrthoDB" id="1103324at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF11">
        <property type="entry name" value="OXIDOREDUCTASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="423"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF10371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="521" mass="59620" checksum="DE55E35638B41491" modified="2013-06-26" version="1">MATVQQQLLRVPNLLYLGVLVGVLIYWLYGRRSQLLKWTEQYGEIMQVQIGWENWIYLNTPDAVKEVLDKHSSVTSGRMPMPVASDLISNGMRFLLMDYTPTWRKLRTIVHKLLTPKASHTFLPSQLFEAKQLVYDILTDNQNQEDFYMHVRRYSSSVVLTSTYGLRVPKWDCEEIREIYGLMKEFSESTAPGAFLADMIPPLGRLPVFLQWWRKRALRYQKRQSSIWMKYWSGLQAQIYQKTAPECFVKQFIETDYQRQDISEMQAAFVAGTMIEAGSETTSAALNSLILYLSADPAVQARAHAELDKVVGTSSSPTFEHEPDLPYIRAMVKEILRIRAVTSIGAPHYTSADIVYKDYFIPKNSVVSLHQYAIHLDPTRYPDPRSYKPERYLDHPLKAGAYVAHPDPYARDHFNFGAGRRVCPGMHLAENSLFITLAKLLWAFKIEPAIGPDGQIQPVDTSDEAYELGSNTLPRPFKARFIPRDAQREQVTRDEWAQARADGFYLGRVKVGVHGMIHGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2023-09-13" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDW6</accession>
    <name>N1QDW6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_49200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758501.1">
        <property type="nucleotide sequence ID" value="XM_016909100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QDW6"/>
    <dbReference type="GeneID" id="27906237"/>
    <dbReference type="HOGENOM" id="CLU_2948366_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF10380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="64" mass="7149" checksum="AB26F7BA55EB9BE2" modified="2013-06-26" version="1" fragment="single">GTPYEILLDNAKYNLGEVEALLRKYGVARLYILLYYPESIAIVKVKYKPIITALSKITDGGKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>N1QEL8</accession>
    <name>N1QEL8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dynein heavy chain, cytoplasmic</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Dynein heavy chain, cytosolic</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">SEPMUDRAFT_151455</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">SO2202</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Consists of at least two heavy chains and a number of intermediate and light chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Cilium membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757553.1">
        <property type="nucleotide sequence ID" value="XM_016906830.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.N1QEL8"/>
    <dbReference type="GeneID" id="27903967"/>
    <dbReference type="eggNOG" id="KOG3595">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000038_0_1_1"/>
    <dbReference type="OMA" id="NERQMTR"/>
    <dbReference type="OrthoDB" id="447173at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072384">
        <property type="term" value="P:organelle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein 1 heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000122">
        <property type="entry name" value="Cytoplasmic dynein 1 heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2620:FF:000001">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.100:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.30:FF:000001">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.180.20:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000071">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000517">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.720:FF:000003">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.130:FF:000007">
        <property type="entry name" value="Dynein heavy chain, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000829">
        <property type="entry name" value="Dynein heavy chain, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054354">
        <property type="entry name" value="DYNC2H1-like_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703">
        <property type="entry name" value="DYNEIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703:SF36">
        <property type="entry name" value="DYNEIN HEAVY CHAIN, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22597">
        <property type="entry name" value="DYN_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0966">Cell projection</keyword>
    <keyword evidence="13" id="KW-0969">Cilium</keyword>
    <keyword evidence="12 18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0243">Dynein</keyword>
    <keyword evidence="7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="14" id="KW-0505">Motor protein</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="19">
        <location>
            <begin position="1009"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="19">
        <location>
            <begin position="1300"/>
            <end position="1512"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="19">
        <location>
            <begin position="1664"/>
            <end position="1819"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="19">
        <location>
            <begin position="2006"/>
            <end position="2172"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="2268"/>
            <end position="2352"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="2494"/>
            <end position="2535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00033439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EMF09432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="3424" mass="388378" checksum="4E2BD15BD7F922BF" modified="2013-06-26" version="1">MPLQHCPKSAHLETLQRAIDTLNLEAYSNIAYWVERTNDKVVETLHARLRQALKDWTDDFENGYGAEQQSSREAGTPNIETFAHDIVMQSQLIQLEPPLEDAKVGWLDNLHTWLSIVCSLPKLQASRFETALAIRSSSTAATYSELPIMCIDTLAELYERIEAKLSTAQLYVDEWLQFQSLWDLQLGQIQDDLGEELDLWLQLILEIRQKRETFDTSGMRRSFGPLVINYEQVQAKVNAKYDQWQHDLLAHFSTMFATRLVDVYSELQRARKDLEGQSMQASSTSQAVSFITVVQTCKRQTKIWEPEMDTFRQGQQTLSRLRFQYPKDWLHVEQVDHEWAALVEVLEKKSKQINDHTEGLRTKIVAEDGVVSRRIAEMTEKWQEQRPESGSTPPAEAVASLEGFDKELTQLQEQHDMVAKAKEALELPSSPDNMLADLLAEVQDYKSVWANLTVVWDQLSELRDQPWNSIQPRKLRQSIENLIKTTKEMPSRMRSYAAFEHLQQHLRQLLKVNPLLTEMRSDAVRERHWTKIFRNLAPSKRYSPLSMSLGDVWDLQLGPSESIIRDVITQAQGEMALEEFVRGVREQWQNYSLDLVNYQSKCRLIRGWDDLFAKCSDHLNSLQAMRHSPYYKEFEEEASSWEDKLNRIHVLFDVWIDVQRQWVYLEGVFTGNADIKHLLPVESSRFANINSEFMGVLKKVYRSPLVLDVLNIPDVQKSLERLADLLNKIQKALGEYLEKERVAFPRFYFVGDEDLLEIIGNSNDTVRVAKHLRKMFAGINGLLLDDEQNILGLQSREGEEVLFKTPISLIKTPKINDWLRALENGMRETLSELLVEAVAEYELLDDSDNTAFEGFIEKYPAQIGVLATQAYWTAQVEAALQQDGALLQKLFETQVSKLRFLATIVLKELTPVHRKKCEQLITEFVHQRDKIEQLIEGGADSPGHYLWLLQMRYEFTASAPPLERMQVQVANATLAYGFEYLGVPERLVRTPLTDRCFLTLSQALCQRLGGSPYGPAGTGKTESVKALGVQLGRFTLVFNCDDTFDFQAMGRIFLGLSQVGAWGCFDEFNRLEERILSAVSQQIQNIQVGLRKRALNDNAQIELIGRQLKVHPLTGMFITMNPGYAGRSNLPDNLKKLFRSVAMSKPDKEIIAEVMLFSQGFSEAKTLSRQTVPFFDKCSAGLSKQPHYDFGLRALKSVLVSSGGLKRTRLAIGGAEGADVVVEPQIIVQSIRETIAPKLVRNDALLMQEIEEEAFPGVKYMPAPLEKLRAALEEVVEERKLVATDSWLTKVLQLYQIQSLHHGVMMVGNSGTGKSTAWQSLLAALQKVDGIEGVCHVIDPKVMSKESLYGSLDSTTREWTDGLFTSILRKVVDNLRGEDTKRHWIVFDGDVDPEWVENLNSVLDDNKLLTLPNGERLGLPSNVRVMFEVETLRYATLATVSRCGMVWFSDDTVDIDVMLSRYIAQSRTATFEDLEEDSGTATSAESRLAVQNLMAEILSRRLTENEFVRKSLEHCAGMKHIMEFTSIRAIGTLFSLLRKACRSVLEYNVSHVDFPLGDEQIEAYLSKKVLLAAVWSFTGDCPLLDRKAFGDYLAGLATLDMPVLSETTSLIDYDVTLPEASWTSWQNQVPTIEVNTHSVTQTDLVIPTLDTVRHEDVLYSFLAEHKPLLLCGPPGSGKTMTLFSALRKLPNLEVVGLNFSSATTPELLVKTLEQYCDYKKSLSGVTMAPRQIGRWLVVFCDEINLPAPDKYGTQRVISFLRQLVEHGGFWRTSTKSWVSLERIQFVGACNPPTDAGRTPLGLRFLRHAPLIMVDYPGELSLKQIYGTFNTAVLKIIPTLRGYADALTQAMIQVYLMSQKRFTPEIQPHYVYSPRELTRWVRAMYEAIRPLETLSLEGLLRIWAHEALRLFSDRLIADDERQWTEDTVNSVALEHFPNLDEETALQRPILFSNWLSKNYVPVARDQLRDFVKARLRTFCEEELDVPLILFNDVLEHVLRIDRVFRQPQGHLILIGVSGSGKTTLSRFVAWMNGLSVFQIKVHGRYSSEDFDEDLRVVLRRCGTKGERICFIMDESNVLDSGFLERMNTLLANGEVPGLFEGDEYATLMTACKEGAQRQGLLLDSQEELYKWFTQQIVRNLHVVFTMNPPSEGLGSKAATSPALFNRCVLNWFGDWSDQALYQVAYELTQSVDIEKANYACPDSLPIEFDQLEMPLSHRDAVVNGMVHVHHSLRSFNDRLMRQQNKQTFLTPRQFLDFVAQFVKLFNEKRDDLEEQQRHLNVGLDKLRETVQKVSELKRSLAEKKTELEKKDIEASEKLQRMVADQREAEQRRAASLEIQAALEKQEKEVATRREVVLNDLAKAEPAVEEAQRSVSNIKRQHLTEVRSMQNPPAGVKLALESVCTLLGHKATDWKTIVSIVRRDDFIASIVGYDNERQMTPNLRSKMEAEYLSKDDFTFERVNRASKACGPLVQWVEAQVNYSAILDRVGPLREEVDQLQEEALQTKAEAKAIMNTLEELEQSIATYKSEYASLISQTEAIKAEMTRVQSKVDRSMRLLNSLSSERGRWEESSKTFQVQMETIIGDVFLASAFLAYAGLYDQQYRRAMLEDWSLQLSASGISFKPQNALSEYLSTADERQQWHENALPVDELCTENAIMLKRYNRYPLIIDPSGRVTDFLQNETKDRRLTVTSFLDGSFVKQLESALRFGNPILIQDAEHIDPILNHVLNKEYQRTGGRVLIQLGKQEIDFSPAFKLYLSTKDPSAAFAPDICSRTTFVNFTVTQSSLKTQTLNEVLKSERPDVDERRSNLVKMQGEFTQRLRRLERMLLQALNESRGNILDDENVINTLEKLKNEAAEITTKASETEGVMNEVNTIMNTYDIIARSCSAIFAVLEQLYHVHHFYQFSLQYFVDIFESVLRAARESAERDPKRRIDTIVRSLFAKTYNETSASLLQKDRLTFAVLLAQAAPFPMDKSLIDLVLDESIVGGDVTSDPGQKAKAVAVAMRVKGIKDLVTDIESPEWEKFLATEQAETCVPGIAAAGGSENDKALKELLLVKLFHLDRLVPATERFVNVVFGQDFLDVAENLGRIVDEQIASSPIALCSTPGFDASYKVDQLVERQNASCTSVAMGSQEGVSSADAALAGAAANGSWVLIKNVHLATEWLQNLVKRIDSLKPNKDFRLFLSMETSPKIPSSLLRASRVLMYEQPAGIRANMRDTLTSLPDKAVQQPVEKARVHFLLAFLHAVVQERLRYAPRLGWKSFWEFNDADFDCSAFIIQWWTDKVARGRSNVAPKSIPWDMLRSLIAEMYGGKIDDAGDMAQLKGLVKKTLTAEAFEDGFNLIGEVAEDESVGMPLPSGSAKTDMLQWVKELPEREPPTYLGLPGNAEKLLLVAHAEEMLKNLKTVMGVLDEGESIMAEATEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1QEU9</accession>
    <name>N1QEU9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">THO complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_66751</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THOC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759753.1">
        <property type="nucleotide sequence ID" value="XM_016909761.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.N1QEU9"/>
    <dbReference type="GeneID" id="27906898"/>
    <dbReference type="eggNOG" id="KOG1874">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000511_1_0_1"/>
    <dbReference type="OMA" id="QERWTCI"/>
    <dbReference type="OrthoDB" id="29024at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040007">
        <property type="entry name" value="Tho2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021418">
        <property type="entry name" value="THO_THOC2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021726">
        <property type="entry name" value="THO_THOC2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032302">
        <property type="entry name" value="THOC2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597:SF0">
        <property type="entry name" value="THO COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597">
        <property type="entry name" value="THO2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11262">
        <property type="entry name" value="Tho2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11732">
        <property type="entry name" value="Thoc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16134">
        <property type="entry name" value="THOC2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THO complex subunit 2 N-terminal" evidence="8">
        <location>
            <begin position="111"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="domain" description="THO complex subunitTHOC2 N-terminal" evidence="7">
        <location>
            <begin position="844"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="domain" description="THO complex subunitTHOC2 C-terminal" evidence="6">
        <location>
            <begin position="1199"/>
            <end position="1496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="420"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="508"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1113"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1511"/>
            <end position="2238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="508"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1113"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1143"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1601"/>
            <end position="1624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1646"/>
            <end position="1665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1689"/>
            <end position="1710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1733"/>
            <end position="1776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1787"/>
            <end position="1816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1825"/>
            <end position="1842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1902"/>
            <end position="1911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1943"/>
            <end position="1956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1963"/>
            <end position="1981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1987"/>
            <end position="1998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="2016"/>
            <end position="2028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="2042"/>
            <end position="2075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2098"/>
            <end position="2111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2118"/>
            <end position="2129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2142"/>
            <end position="2165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2188"/>
            <end position="2208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF11262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF11632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="2238" mass="248420" checksum="BEE1E8EF1BE06A92" modified="2013-06-26" version="1">MAPPSGKRKRPERQHSDDASRASPYRPENSRMASQRASKAGAVAEPTTDEARSSANTPLNGNGGDASHLETPAENGDVPVSGSTPTNNGEAAIEDVPSDQRTPYQYSYLVDEVVAVWTDTGGQSILDTAATLDEMQLSDLVQELIRSALDGRLTGQQAGHTVRALIAAKHESDGVDVEFLFLNNLSFLFESGHKDQVLKGLVAATGIDQETMRLELDIPLLQELSLVRSTFEKMRTRKTTNALYRQANFNLLREESEGYAKLITEYFNTAQQAFEKRNGDDPFIAEDAFQRVKALVGAFDLDVGRVLDITLDVSADLLVKAYPFFMKFYRASSWWPSDESLDNLKWEDQGFGTLPAWCLPGSGRSAFTTEEREQLTALRRTRDVRFWQQVREVGTKAFFELGARKIVDFDSALPLLEQEAQPELDSRGKETNQHKRQRVNEDRKYMRETRHLPPPGNYDAAQLLGFKLRFYASDARDPQDTLPDNLIYLTALLIKIGFVSLRDLYPHLHPSDQDMPAERKRLEKEKAEKDAKDRPGGGMNALLMAGALPDDTPVSRNTRLDKSKNGGTTPAPDKKDDAKPELPPPTNQKLYLLKALLLIGALPEALYILGRFPWLAEVDTELPAFFFRILRHMLSNMTESVKPLHGLSDMRRTNDRLSNTTVQPNGQLPVSSWSAKKPIRWLHNDCFSKSGDEYRHYYSDWSDNIPLCQSSDDVYLLCDTFIGFLGPKIGQDPEIYGTLLRLAEQSLVGDASPANRTRWLTILRRLLIPALSCGKHNPQLSQQVFDLLKLYPLSTRYNVYAEWFSGSTSRQADVRDAFARNKAEVRDVLRRVSNDTVRKQGRALGKVSLAAPGIVMVEMISQLEVYANMIPSLVECTRYFSPMAYEVLTWALINSLSGNDRNRMQGDGMLTSPWLQALSRFVANLFSKYTYLNPTPILQYLASKLRSGETTDLEMLEQILVEMAGIRSDVEFNDTQVLAMAGGVSLQSYILEQLSDKRHTKEKEKPARRLMQCLSNSGLVGQLLIAIAQDRKLYAHGEELRFAPLKVVGNNLDKISAVFAQYLDALKWNLKPQELEAAVPEVGVLVHDFGLEPSVALLIHRLAVRSRMNDYDAAKKQENEKKEKEKPEAAPANKSSDTVMEEAPVKPADDAEDIDAKAADSKHMDIDSANPLQSSSPWHPVLEPVIQQLTDALPDLAARLSIPFYVTFWTLTHQDVLVPTDSYQKETNRIEQEIKQINADRSDLTSIATKERDARKRALQKWYDSLKSEPMQHMAAYMAVRNRITVDPQQIKAAIEAKHQALLQECFLPRAMLSAIDSHYSFEMMKLMHQNGTPGFSLMHLLFQLFKKKQLCSLIFGCTQNEAQHLARFLLETLKLLHRWHADQSTYEKEALGLKKKLPGFVKVFEATGEPKSVMDWQTFRRMLFNIHVALNGALQACFESGEYMHIRNGIMVLKGIHQVFPAIKFHGKNMIDQVERLSKEEQRSDLKLAAMSLRGPIQNREKQWVLPQNFRLGEGAKEGAKTGGQDSSGRPETPQPGAAKLNASAPDFKPTLPIGPPRKESAVEDGEIRDEKVAAAKAEVTVSQSIKDVASADSAPSSRDTPKLADSRPARPLPDRDGLRSESKSSTPAPFPAKSAPHSGMPLRPDSRDASHRMESSRPPRDLPNRPQESAYNRPLPGQSASRNSGHYGDRPDDHYGRLERGGEVRPASRDQSPSHRSGRGRTPPGSNPRGTYRDERPYDRGPADGRYGREESRGSRHDAPTHQNRHAPESRDRPPLSSRASDSGLHPDRMGHISSRPHVEHEQRRERSHLDDRNGPPPFQARSDSRTNGRLADSSRDAPNRSEQQQDLAPRGSRSRGPRLQEMPPPSAESTYGRLNAPAEPPTGPKNGPGGNRSGRNFTAPPPGTPSLPSPTLTRQPEHSTPVAPRGPSRQASGHMDRVSAPNSAPSTPATETGPSVHPSRLTNVGQPPQPAQIQTNFAPNGPRSVSAASPMTAAPPSAPRGPGRHGTSSSTPTGPPPVSNVPPSGPATIAERQQKNRQRASINATLQGNGSQASPQGVQFRGASSRQSSISNAPPMAPPAVPASTVDLFQNRTDSGNERSHRHRDDGRQSSSRHQSRERSHNESFGHGHAPPPPPGPADDGRSRRDRSARDDRPRDSARDGSRASGANRMAPSGPQAEFRGGQHPRREEDRKESSGRGMPREEHGPPGGPDGRKRRHEEAQQGFDPTKRRRSGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1QEV1</accession>
    <name>N1QEV1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNI-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_149603</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759809.1">
        <property type="nucleotide sequence ID" value="XM_016905653.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.N1QEV1"/>
    <dbReference type="GeneID" id="27902790"/>
    <dbReference type="eggNOG" id="ENOG502RSHR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003789_0_0_1"/>
    <dbReference type="OMA" id="CEDAPCF"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052394">
        <property type="entry name" value="LRR-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057334">
        <property type="entry name" value="PH_2nd_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25353">
        <property type="entry name" value="PH_2nd_LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="170"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1042"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1199"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1289"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1073"/>
            <end position="1085"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF11688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1315" mass="144137" checksum="2CF6847A211F49E2" modified="2013-06-26" version="1">MSSARNSDVSSVSSATARRPRRSIFALAGLRSSIDLPNDTKNHHGSPAGKTSKTASKLSKKQKHLRAPSVFTDPHQPDAARDDSKGVPVLDQPRSQSQSRPSFSMRSSKRPPSVFESLKTSLTRGSSEDLLSMAYTTAEPLSTTSSKAPSLVFDHTHEANGGVSPGPSRNVLLHGEVQTSAGMFRKKKEYLVLTEHALLRYKTQAKAAEHFRTIPSAAGRSPVQRHGSMPSGGSYSDLQTVSDSSGDKDGRVPLRQIVATQKLDDGKPYFALEVAYLDDDSGSASVMTLQFSNPEERDGWLVRIRSVANEVRLRDTTFISPHNLENAARIVERDNDYDPSNCAIYKVVQRQPAVKSGSRSSSDDLTKVASTVCFLAIGVHKVHLIQLMKPVARTSSPSLTPNLSQASYGILTLIGVKVGVEDDTFELVFRQPLQKPRILHLASASSFEIAARLHWSENFLRPECGYRLFKFKVPTEVDDLLLPPAAADVEEHGCLDRTLIAYCVAYGVNPSNIRYTINYDCEDGPRFELLTPGDSRRPSYGPLELLAIMRAIRYNESFGSISFAGVLLDSLNGLHDHYGNEHVCTRTKRGTPIKLTADELTRSSLLVQEVRAIAATSKKLRRMDFSGCVTSKHSTVEGDDELARDRDIGSGVVEALFPLCKHQTTNVDWICLNGIELSETDQDYLVGAAVDKSCHFRAIELNRCGLNDRSLGLILDALRTQDNTLESLEIAGNAARLSPTSFDSQLGMFGFIRKLNLSNVSRTSGAEPFIQAETLLIWRLQELRLTGTSLNAATIDAISTYLAHPQSTSLHELYLDNTYLSGHDVATLLHSMSWDSKTTRDMHLDIGQCILSKGLEKVTQAISSNLTPSQLSMRAIEYKEQSHFQKVLKAITKNKTIRCLDMSQSALPGDASEETCEAITRLLTENNTLVELDMSGDDSRLATSRFGPGINDALTGLKDNKSLQVFKIEKQKLGIRGASTLAEVLRVNRTLLELHCDNNEIPLHGLTDLVNALTDNTVLVHLPTMNDGRSAAFRAAEATMRTMSDIEPSRPQTGGKGSHLPSSSVRKSFASVRKTTSRAASNYTPSFPALGSYGRPTPVSESRNASHLSLALPAHKKGHGSSPSTSQFAPFTVQDVQTTHRLLTEQWERQCYRLEQYLHRNWCLLNNVPVKMEIEDEKFERPSSVGSIGKMLEQVKYDTTPKADLEPRVGYFDSPQDAPSEQSVDFPTPRRPAASTAGGPPQISPIDESKHGMSFKHFVFDGSGSPLSSVLPSDDEQFRSISGNMRDLRIDTTIGDDGPRTPTQSAFAAVGGGPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1QF17</accession>
    <name>N1QF17_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_120490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757773.1">
        <property type="nucleotide sequence ID" value="XM_016901609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QF17"/>
    <dbReference type="GeneID" id="27898746"/>
    <dbReference type="eggNOG" id="ENOG502TEMK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1511511_0_0_1"/>
    <dbReference type="OrthoDB" id="3650424at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="19895" checksum="C2DC3DEB50BC44F1" modified="2013-06-26" version="1">MSTNLTLTARELELLKEVGKHLQTASVDWSSVAQNINYKTPKAARDKWYPLRDKLFGGAAESTNNTSSSSSSNKKSGGGGKDFATTPLRAKKRKFVHAIQDNNEDDEEFKQEEEKGTPSRMKTSKKIFKAKATDKGKNAATAENEAENEEDEVKVEVKPERVDNDEDDEDEDQDGYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFB4</accession>
    <name>N1QFB4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Autophagy protein Atg20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_150532</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758533.1">
        <property type="nucleotide sequence ID" value="XM_016906240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QFB4"/>
    <dbReference type="STRING" id="692275.N1QFB4"/>
    <dbReference type="GeneID" id="27903377"/>
    <dbReference type="eggNOG" id="KOG2273">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014456_0_0_1"/>
    <dbReference type="OMA" id="CRRMKEV"/>
    <dbReference type="OrthoDB" id="289314at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06867">
        <property type="entry name" value="PX_SNX41_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044106">
        <property type="entry name" value="PX_Snx41/Atg20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051079">
        <property type="entry name" value="Sorting_Nexin_Autophagy"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46979">
        <property type="entry name" value="SORTING NEXIN-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46979:SF2">
        <property type="entry name" value="SORTING NEXIN-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="11">
        <location>
            <begin position="90"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="217"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="445"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="411"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="63"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="455"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF10412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="629" mass="70048" checksum="CEE2C90528D744FF" modified="2013-06-26" version="1">MWDDEDNNPYGAFERRDSETSEILSPTERYHRPSTPPSGHSSPEQTPHFMSRSTDLSDEDLNDDRRSGVKVQPKEGGYDSRIEQILYEHPELQIEIVQAGKNTEGGGGYITYTIRTGEVVVRRRYSEFASLRQTLVNLHPTLVIPPIPEKHSIADYAAKPTKAKEDAGIIELRMRMLATFLNRCRRMKEVREDGVWWRFLDPNVSWSEVLHSHPAASIPKNNLKAPPLDPANPTTAHQWLPVPSANAKLRSSSGSSASGTPTSPPRVAATPSAAAHSTPQIQYARFPPLNQNLSEGELDPYFSSFENSSKELETLLTGSMEKVNARLLRHLASLGDDLMDLGARYNAFSLSEQSTSVAHAIEKAGQACDFTYIQSRDLNSALSAGFAEPMRESAQFASVVRSVLKYRVLKRVQEEMTRDELERKKSKLAQLEQSEIEAKRIEQYMTSSGIHNIPRRSASSGSNRNRPSTSDGDNASVDSDFPPSGGEPASAAEHDTPQEPYGSPPARSASNGGHKRGSSGIVNKIFGRVTHTIQGVTDQDPERARRDDLGKTKESLVQLEQALDVSQKDVKDASQGVLQDLRRFQGTKEDDLRMYMLNFAKAHIEWSKRSLDEWQKAKMEINKIEVRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGN1</accession>
    <name>N1QGN1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell wall assembly and cell proliferation coordinating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_66755</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KNR4/SMI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759755.1">
        <property type="nucleotide sequence ID" value="XM_016909762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGN1"/>
    <dbReference type="STRING" id="692275.N1QGN1"/>
    <dbReference type="GeneID" id="27906899"/>
    <dbReference type="eggNOG" id="ENOG502QTAZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024700_0_0_1"/>
    <dbReference type="OMA" id="ESLMVHD"/>
    <dbReference type="OrthoDB" id="2305498at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097708">
        <property type="term" value="C:intracellular vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070880">
        <property type="term" value="P:fungal-type cell wall beta-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1580.10">
        <property type="entry name" value="SMI1/KNR4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009203">
        <property type="entry name" value="Knr4/Smi1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018958">
        <property type="entry name" value="Knr4/Smi1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037883">
        <property type="entry name" value="Knr4/Smi1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051873">
        <property type="entry name" value="KNR4/SMI1_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47432">
        <property type="entry name" value="CELL WALL ASSEMBLY REGULATOR SMI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47432:SF1">
        <property type="entry name" value="CELL WALL ASSEMBLY REGULATOR SMI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09346">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017023">
        <property type="entry name" value="KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00860">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160631">
        <property type="entry name" value="SMI1/KNR4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Knr4/Smi1-like" evidence="3">
        <location>
            <begin position="145"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="19"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="371"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="492"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="41"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="504"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="541"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF11634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="551" mass="60641" checksum="ACD0DAB0559A342D" modified="2013-06-26" version="1">MAGALASQWRSFWHTMTSNDRHAGPDSPYGRGNGHVAISQSKSALNSSHNNNSALESRTDLDLEAGNGFVNSTPSAPGSPSQRSSLSRTNTGMSGKMADVSTGEIQMQAFSDGLPPPPPVSHSWKRIDRWLEDNYEELFENLGMGATVNDVNMLEHELDCTLPQEVRESLQIHDGQERGGLPTGVIFGCMMLDVEEIIQEWQQWRTVNEAYLSEQRSYEIPQAPLKAFAGSSSSAVPIAQAQPTSNPQWRAELLDKQDSQPPNAIQKVYAHPAWIPLARDWGGNNIAIDLAPGPTGRWGQVILMGRDYDCKYVISRSWSAFLATLADDMHTDKWFIDEDTKELKLREFPKQGVEPAYIDILRWRSDQKYGRRAPKKRPLRINSNVSPGANGFSPYGSPTKEDRGRSPQRFANGKAPMHNSSPRGHGGVGSPLARVTEESSPITAVPPQPLSLDTAAIETRSNEKLISAIDTPTFAKSDKGKEKLVSGIDTPVVANGDFDERRTSQPYPRSRLGSSMMSNSDDEEKENVTPSKSLGKPSVESVEDDMKDVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGV9</accession>
    <name>N1QGV9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial distribution and morphology protein 34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MDM34</name>
        <name evidence="13" type="ORF">SEPMUDRAFT_118938</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM34 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion outer membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="10">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the MDM34 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758504.1">
        <property type="nucleotide sequence ID" value="XM_016901463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGV9"/>
    <dbReference type="STRING" id="692275.N1QGV9"/>
    <dbReference type="GeneID" id="27898600"/>
    <dbReference type="eggNOG" id="ENOG502QT3W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036502_1_0_1"/>
    <dbReference type="OMA" id="VFRAWSG"/>
    <dbReference type="OrthoDB" id="17927at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21673">
        <property type="entry name" value="SMP_Mdm34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03105">
        <property type="entry name" value="Mdm34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027536">
        <property type="entry name" value="MDM34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058825">
        <property type="entry name" value="MDM34_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28185">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28185:SF1">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26545">
        <property type="entry name" value="Mdm34_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SMP-LTD" evidence="12">
        <location>
            <begin position="1"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="198"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="349"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="569"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="356"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="465"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="489"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="513"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="569"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF10383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="597" mass="65299" checksum="356F03E66DED1225" modified="2013-06-26" version="1">MAFNFNWSPLIADTDRVRDMLTSALNKSPKPPIIVDDIIVNELNLGATPPELEILEIGDLAEDRFRGIFKMSYAGDAYLTLKTRVQANPLHTYLSTKPSFASPQPLAASSSLTIPIQITLSEIRLSGFVILVFSKSKGITIVFRNDPLEQLKVSSTFDSIPFVRDYLQKTIENQLRVLFMEDLPAIIHRLSLSKFRPEYQTAEDQEPRKADLAPGEVPVDPLASPALQPTPDGEETMGAPFTLDPPTETYASFSQKNMIRLATLAESQRTLSLFTPAMRDTVYRAWTGTYREEMGGTIASTRPGLARLHTSIASHSTVSSATSLASGGGTEATRPSLVSMASTATLYSLGSSGSRARPKKRKHRIVNLRKNKDEGHTLENASVGTSGYDESASQTGSSPSVVRSGTQATSAIGGNAREGEISTPPRSPKKKVDFHTDNVDGAVDRPPLSRSRPCTPKTSLPPLAHPDDDLDRTPRASMYLPKKDEKNVPRTSTTANNAVRTQAFPSRSPSPEISRRPPYDFRHSSSDLSRTSSDIKLQSLLTAFSEGGSGGILERAWLEKMATEIAKKVEQGRAEQKAWRQPSEERIMEEAPPAYVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGW4</accession>
    <name>N1QGW4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Centrosomin N-terminal motif 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_150520</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758509.1">
        <property type="nucleotide sequence ID" value="XM_016906233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGW4"/>
    <dbReference type="STRING" id="692275.N1QGW4"/>
    <dbReference type="GeneID" id="27903370"/>
    <dbReference type="eggNOG" id="ENOG502SSWS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_334679_0_0_1"/>
    <dbReference type="OMA" id="RSANTMK"/>
    <dbReference type="OrthoDB" id="10251744at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012943">
        <property type="entry name" value="Cnn_1N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07989">
        <property type="entry name" value="Cnn_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centrosomin N-terminal motif 1" evidence="4">
        <location>
            <begin position="110"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="200"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="387"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="543"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="247"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="396"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="450"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="661"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="687"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="711"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="727"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="822"/>
            <end position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF10388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="853" mass="94482" checksum="BE2ED4F20B018D4E" modified="2013-06-26" version="1">MPAGSMSLYDDPERSPLGQRGMHVLPASQYLQERLSERRARQLRPKRARHTDCGPQSPRGRDDDIFFAEARETRDTRMYDSSPLVAASSRASDAGTQQNGDRPRRRTVGLRDMDEQMDRLQKQNFALKLELDHRREQTQKLQERMGSMQDQVERALLMEDEHKELLRINSELVQELEKRDRAVEEAMDLICDLEDQVGELQEHSSNTRPSTAHADSGYAGTEALDQDSRGSPPRPAVASKAAVVNTQPPSAQASAASHNLHDALNMQATAKPKRQPSVLSSRQPSTHALRSVYMENSRSLRPVQSFQSLLERQDHKVEEDSDNLSISPRLSVLSESSFPSIYSPKKDLSPDRYDWEVADEAGGLPAPLGCPAHMRQDSIKRVSQWMSARDAVEATPSKSNRISSPLQDESGRHSSASSLGPYQSLNDALSSGVEPVAAPAPPADVDREHHQHHLRKQKSGRLRTRPVSYPVNELHMPPTPDSVSTRMLRESHSSIGKDKSLLDTTPAFVKDYSTLEPGLRTAPRQMRSSVELRTAYNSNLQFRSTALDGHRQEDSSDDEEYIRQEPPCGEKSKDSTFAYDDFPDGGSITMGTPRRFQSHARPPADVMFNHSDISPTLKPPAPGRRRSSQQTIGEPAKSGVSAQPCHEDGVLSVEGVVSPRSARSQRSNSSGNRTVTLGDEQSSRTLSPAASRATAVTSPRSRTSPSPARTLSKKMPKFIRRLSNTMLSEGSPLPTLTSTPSSAYANSGPPRPRTSHADRIPRNNGGATMPRPPSSREIRPQPPIKVLKDMNVVRPASAAGTERERRSLFRRSNSTKKKDQSDGSASDTQQMRGVAVKRRGSIRDVVTSRRPWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>N1QH44</accession>
    <name>N1QH44_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_150575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758599.1">
        <property type="nucleotide sequence ID" value="XM_016906265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QH44"/>
    <dbReference type="GeneID" id="27903402"/>
    <dbReference type="HOGENOM" id="CLU_2706400_0_0_1"/>
    <dbReference type="OrthoDB" id="10439595at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF10478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="73" mass="7738" checksum="AD0E1F5A9C2D680F" modified="2013-06-26" version="1">MTSTYTPSVCCPQIPAETAFDLIECGGCAFTTETVPLNCLMPCTVSPTVDLALTTTITECDQTISLTDPVTKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1QH66</accession>
    <name>N1QH66_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cysteine synthase 1</fullName>
            <ecNumber evidence="5">2.5.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">O-acetylserine (thiol)-lyase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">O-acetylserine sulfhydrylase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">O-succinylserine sulfhydrylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">SEPMUDRAFT_87030</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the conversion of O-succinyl-L-serine into cysteine, the last step in the cysteine biosynthesis pathway. Can also use O-acetyl-L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>O-succinyl-L-serine + hydrogen sulfide = L-cysteine + succinate</text>
            <dbReference type="Rhea" id="RHEA:53816"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:136856"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="5"/>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759915.1">
        <property type="nucleotide sequence ID" value="XM_016910432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QH66"/>
    <dbReference type="STRING" id="692275.N1QH66"/>
    <dbReference type="GeneID" id="27907569"/>
    <dbReference type="eggNOG" id="KOG1481">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021018_1_0_1"/>
    <dbReference type="OMA" id="VVTVFWD"/>
    <dbReference type="OrthoDB" id="10259545at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000011">
        <property type="entry name" value="Cysteine synthase (o-acetylserine)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000049">
        <property type="entry name" value="Cysteine synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007989">
        <property type="entry name" value="PRK10717.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="19">
        <location>
            <begin position="56"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00058228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00072087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00078262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00079147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00081847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EMF11794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="387" mass="41585" checksum="CFB957671858994D" modified="2013-06-26" version="1">MFARTAIRAATKPVAFRTVRTAVTIAPSVSEVHAMNPHGLDISKAQGVAKNGLVSAIGNTPLIRLNKISEQTGCEVLGKAEFQNPGGSVKDRAALFVVKDAEEKGLLKPGGTVVEGTAGNTGIGLAHVCRSKGYKLVIYMPNTQSQGKIDLLRLLGAEVYPVPAVAFDNPENYNHQAKRHAERLDNAVWTNQFDNTANRQAHIETTGPEIWAQTDGKIDAFTCASGTAGTIAGCTRYLKTVSEGRVKCYIADPPGSVLYTYVSSGGKLVDRTGSSITEGIGQGRVTDNLKPDIDLLDGALHIPDEKSIEMVYRCLDEEGLYLGASSALNVAAARDLAEKLGPGNTVVTILCDGAYRYADRLFSKKWLETKKLTDAVPEHLRKYIVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1QH74</accession>
    <name>N1QH74_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_120221</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757485.1">
        <property type="nucleotide sequence ID" value="XM_016901582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QH74"/>
    <dbReference type="STRING" id="692275.N1QH74"/>
    <dbReference type="GeneID" id="27898719"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_6_3_1"/>
    <dbReference type="OMA" id="SANCGAW"/>
    <dbReference type="OrthoDB" id="417877at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF1">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G06050)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="356"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="330"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF09364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="507" mass="56120" checksum="38235303B9F618C3" modified="2013-06-26" version="1">MSSPPPKPFHIAIIGGGLGGISLGIALSRRINKNKSTNKNLPFTFTLYESRSSFTEIGAGINLGPQAVRTFRYIDPLLGEKVYALTTRNPSPNEEVWVDLRWGGSDEISNTTTTTTAGDGEGGKGNERVDGEVFHRILAPPTGNMTVHRREILGLLAEEMGGENVKFGKKLEKWEQQGTAEDDVVLKFADGTEERASVVVGCDGIHSNVRACMFSGDDGKKLSKAVFSQSGCYRAVVPMEKAIEKVGEEARLSTIMLTPGGYMITYPISHGTQLNCAALLPRRETPTWPHTEWIIPHQGAAFHQDCSNWGPRAQKLLSLFDPDPDFWATFQHHLPYPPPPPPSSHPEDPDGHVQSSSSSSSQIVDGRVILIGDAAHSMPPHQGAGASQALEDAFVLAEVLEEVIQIASTSDKNPHHIPFNHVEAALRAVEEIRTPRFTTVHRYSTEAAERFFYMWEKKLEGEALREWIDETERRLRWIWEGDMAVDAARAKELLREELGKMEQQRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1QHJ6</accession>
    <name>N1QHJ6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase</fullName>
            <ecNumber evidence="5">2.7.8.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">GlcNAc-1-P transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">N-acetylglucosamine-1-phosphate transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">SEPMUDRAFT_150668</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis, transfering GlcNAc-1-P from cytosolic UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol embedded in the cytoplasmic leaflet of the endoplasmic reticulum membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a di-trans,poly-cis-dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-alpha-D-glucosaminyl-diphospho-di-trans,poly-cis-dolichol + UMP</text>
            <dbReference type="Rhea" id="RHEA:13289"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19507"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58427"/>
            <dbReference type="EC" id="2.7.8.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:13290"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 4 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.15" evidence="5"/>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758749.1">
        <property type="nucleotide sequence ID" value="XM_016906323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QHJ6"/>
    <dbReference type="STRING" id="692275.N1QHJ6"/>
    <dbReference type="GeneID" id="27903460"/>
    <dbReference type="eggNOG" id="KOG2788">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029942_1_0_1"/>
    <dbReference type="OMA" id="LPHFNAR"/>
    <dbReference type="OrthoDB" id="10262326at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043541">
        <property type="term" value="C:UDP-N-acetylglucosamine transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003975">
        <property type="term" value="F:UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06855">
        <property type="entry name" value="GT_GPT_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033895">
        <property type="entry name" value="GPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10571">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10571:SF0">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="429"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00045078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EMF10628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="461" mass="51743" checksum="81FF322FC334AA1C" modified="2013-06-26" version="1">MQPLSGTETTALASISFACLTVLVSSWRNDGEPLYASLAISGLAYAFTYCTIRWTGDVFIKQGFGGDDRSKKHRPRLPEMMGLVCGLVYLLTLIFFLPFAFRRAFVEVTSDAWNKERTLEAQQIETGRFLHKFPLEKLASYGFAYSTLASVIILGILDDTFDMRWRHKFFIPAFAALPMLGLYFVDFGVTHVVVPLPLRGYLGELVDLGAIYYAYMAAISIFCPNSINILAGVNGIEVGQSLVIAMLIALNDVLYLLPTVQQPHPAAESHLFSIYLLLPFVGVSLALLKHNWFPAQVFVGDTYCYFAGMVFAVVGILGHFSKTLLLLFIPQVFNFVYSAPQLFKLVPCPRHRMPRFNARTGLLEPSTAHPAEDGWKDMRPIVGEVLKVLHQVKLVRVAVDETGKVIETSNLTLLNLWLVWRGPLREDRLALEVLAMQTVCGLVALWTRHFFARMLFAMDNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>N1QHZ1</accession>
    <name>N1QHZ1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6604 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_110034</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758894.1">
        <property type="nucleotide sequence ID" value="XM_016900820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QHZ1"/>
    <dbReference type="STRING" id="692275.N1QHZ1"/>
    <dbReference type="GeneID" id="27897957"/>
    <dbReference type="HOGENOM" id="CLU_375154_0_0_1"/>
    <dbReference type="OMA" id="RETHECH"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046539">
        <property type="entry name" value="DUF6604"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795:SF1">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20253">
        <property type="entry name" value="DUF6604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6604" evidence="2">
        <location>
            <begin position="37"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="657"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="683"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="711"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF10773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="740" mass="81521" checksum="0F6C876B486374E7" modified="2013-06-26" version="1">MHSGPRPWGHRGKQPTELPGPYLQAMLNDRTIDDGAYKRCGTVLTNWLIKTGKLVNCRSVDLTNVRRKLTLTQLEKVAQSIVNSSNPSIVVPIEIISAVQVIVAGRRETHECHLRAYAVNPSPEIAQKNDSHRHALTVHENVLAFLQLNSESRHVTSTSSSESSVHDCGDDYESATENSIPCGPGLAAGRPKVCIKDIPAIFSLLSDLSETRLWVKKIWRGFNVGEISFIAVSKMTDIAFRKCQELITVFEAEYSCCCSYQAILRGWDLNDDVWIAALDMSTSGGVHKSDTGLLAEVCSYMPAYRVTHYITGRMFQTRTGSPDTGARPVLSQSGALHPFLESLVAVVSQLCSLSDDSHGHSAGDPLDHELDTFTHELLKSRPGEESMLLVAMMRMYLDIYDSLAGDLQRDMVSSRQILCHLEAAKHRFFQFYTGCNDNSQANGTTKCLSELMGHLSLAECRSWRTSVRVPNELLKTLPLLRGAHVWDCLTRHHRLSIVLCKAKRSEVAAAHLHKTLVPCVEWPGMDLLLSIVQGPDSCPDTTSTNTVMGHSIHASDPTSHAGLMSDTAETAVPSNIAASDQVQMDLVTLLNNPESCSLPPPANLGLSQRWLADLKTQVVRDMPSVQVNHLQALQQCLEILQHISGRNIAPKTELDRESASHSLAVNSEARENMSSVEEEAKEEEQAVPKSEKRTATPKDKPLQALRLASLINGTGRSCTPRSIEYHTQPYPSALPRWTAA</sequence>
</entry>
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    <accession>N1QIJ0</accession>
    <name>N1QIJ0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase family 16 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_67957</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760365.1">
        <property type="nucleotide sequence ID" value="XM_016909802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QIJ0"/>
    <dbReference type="STRING" id="692275.N1QIJ0"/>
    <dbReference type="GeneID" id="27906939"/>
    <dbReference type="eggNOG" id="ENOG502S1W9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019533_3_0_1"/>
    <dbReference type="OMA" id="NGKWTSA"/>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF60">
        <property type="entry name" value="GRAM-NEGATIVE BACTERIA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110865" evidence="1">
        <location>
            <begin position="18"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="12"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF12244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="302" mass="32651" checksum="1EEE98E63D88085C" modified="2013-06-26" version="1">MKTSAFTLAFAASSALASAPSTINTSWKKTLFLDDFTGGSGSAPDSSKWIMQTGTSYPGGPPQWGTQEVQTYTSSGNNIRQAGNGDLWIIPTRSNTNNGNGTWTSARLETRQSNFQAPVGGKLRVEARIKIPNVIGSNAAGYWPAFWALGSSFRQNNNYWSWPSVGEIDIMENINGQDSVVNTIHCHINPGGICNEPNGLGGTYNCSGSRCPGNYHIYEIVIDRSVKPEVVKFWVDRKLKRTVSQTQLGSAWTKTVNSGFFLILNVAMGGAYPNAVAGMQTPTNETVSGREMAVDYVGVWST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1QIS6</accession>
    <name>N1QIS6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aflatoxin b1 aldehyde reductase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_146216</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765247.1">
        <property type="nucleotide sequence ID" value="XM_016903523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QIS6"/>
    <dbReference type="STRING" id="692275.N1QIS6"/>
    <dbReference type="GeneID" id="27900660"/>
    <dbReference type="eggNOG" id="ENOG502QU2T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_1_1_1"/>
    <dbReference type="OMA" id="NYWHGDL"/>
    <dbReference type="OrthoDB" id="2310150at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19075">
        <property type="entry name" value="AKR_AKR7A1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="13"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF17126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="350" mass="39623" checksum="3CDE6A8F444818E6" modified="2013-06-26" version="1">MPLINGGTGKPRVILGTMTFGPDESTGARITSLDDYKSCLDHFQSRGYNEIDTARVYVGGKQEAWTREAGWKDRGLMLATKWYPHTPEAHKAEKIEEMLNKSLAELGTDTVDIFYLHAADRSIPFTEPLKKLNELHKQGKFVNLGLSNFTAAEVAEVQMHCHYNNWVRPTIYQGMYNAIQRNIEPELITTLKRYGMDLVIYNPIAGGLFSGKIKTTDIPAEGRFSDTSSAMGTNYRKRYFRDNTFEALRLIEPVVQKHNLTMLEVAFRWLVHHSKLNIKDGGNDGIIIGVSSQAQLESNLTDIEKGPLPEEVLKVLEEAWLITKPTAVPYWHGELKYTYDTVDALFGKHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>N1QIY5</accession>
    <name>N1QIY5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_67051</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759901.1">
        <property type="nucleotide sequence ID" value="XM_016909773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QIY5"/>
    <dbReference type="STRING" id="692275.N1QIY5"/>
    <dbReference type="GeneID" id="27906910"/>
    <dbReference type="eggNOG" id="ENOG502QVYJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010170_2_0_1"/>
    <dbReference type="OMA" id="RDRIWKS"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF9">
        <property type="entry name" value="TAH-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="31"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="73"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF11780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="710" mass="78724" checksum="AF5C09CA90DE8F58" modified="2013-06-26" version="1">MTDETSEADGRSTPHAPRPEKRRRIERVVAACDLCKARKVKCDGELPCAYCQRKKRADTCIFTAPKQSTDVARRRRTYSAGAERRPRTSDGVGEFGASLSRTDSREDHQNDTAVPLEGRILRDAQGKVIFIGDCAPLSFLQTVRHLIASEVDVEGLAVAASRDSIIEVAKTKKADGPTSLIVDVRNVEMLVGEYVVAVSGLADLFEHTQLLHEVKAWASGFTSHQNVTSAVHYLILAIGAQQSNEVQAESWFEHAKDVLLKHLTTSMTLSTVQGFTLVAVYMLRAFQPNGAYLYFSLAARTAYAIGLHRTEVNATYGAAVRDTRDRIWKSLRVVDMLISNLLGRPPSTSDVDCTVKYGKHGVAEVSFGHSLHIIDASVQIFMIIERVVVEVYSRKRISLRIASYVSHQLKGWASIWLRFLSDRTAASPFSTGVGDQDTFSREVVVGACSTLCSYYYGIMLLTRPFLIYELYEYMGASLKAPGTHNEHQEKRKYADAALDAATSFVETLEVVLKSNHMPQRMPLVVSWLFTTSLVLAVGILGRSGTAFEDHCRASIACLDYFAEVDPHARQYSLVVQALLKTTTTHVKARELRLRSQRKQASSQLFGLLPLDNEIPAAQQSQLDQDASDALDRRPSTIGALENSHGQDASTETAIPDWTIYDADFFALPWLNESDQGLQDFLQPGRHTLDGENLADIPLFPMYDQMGGSFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJL8</accession>
    <name>N1QJL8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2'-phosphotransferase</fullName>
            <ecNumber evidence="3">2.7.1.160</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_11369</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2'-phospho-[ligated tRNA] + NAD(+) = mature tRNA + ADP-alpha-D-ribose 1'',2''-cyclic phosphate + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:23324"/>
            <dbReference type="Rhea" id="RHEA-COMP:11106"/>
            <dbReference type="Rhea" id="RHEA-COMP:11107"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:76596"/>
            <dbReference type="ChEBI" id="CHEBI:82883"/>
            <dbReference type="ChEBI" id="CHEBI:85027"/>
            <dbReference type="EC" id="2.7.1.160"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KptA/TPT1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.160" evidence="3"/>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765552.1">
        <property type="nucleotide sequence ID" value="XM_016901047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJL8"/>
    <dbReference type="STRING" id="692275.N1QJL8"/>
    <dbReference type="GeneID" id="27898184"/>
    <dbReference type="eggNOG" id="KOG2278">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052998_0_0_1"/>
    <dbReference type="OMA" id="HATWPKI"/>
    <dbReference type="OrthoDB" id="419694at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000215">
        <property type="term" value="F:tRNA 2'-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.970">
        <property type="entry name" value="RNA 2'-phosphotransferase, Tpt1/KptA family, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002745">
        <property type="entry name" value="Ptrans_KptA/Tpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042081">
        <property type="entry name" value="RNA_2'-PTrans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042080">
        <property type="entry name" value="RNA_2'-PTrans_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684">
        <property type="entry name" value="PUTATIVE PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684:SF2">
        <property type="entry name" value="TRNA 2'-PHOSPHOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01885">
        <property type="entry name" value="PTS_2-RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF17431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="252" mass="28221" checksum="90BACD9D3AF6C0C7" modified="2013-06-26" version="1" fragment="single">RPPPPRPVQVSKKIAWLLRHGAEKEHLTLDSAGFANVHDVLENRNLKSLKVTFDELRACVRENDKQRFTLKLRSKSADTKDDDEDENEKESKNPSDYLIRANQGHSLKKIIQDQELLQPITATEENNIPAVAIHGTTKNAWKLIVASGGLKPMGRNHIHFAPGLPAEGKEKEKEKEKEIPVISGIRASSKILIYLDLAKAMQAGIKFWRSDNGVILSEGDENGLISMHFFQRVEDRTKEGGGAILIRDGKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJS3</accession>
    <name>N1QJS3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]</fullName>
            <ecNumber evidence="8">1.5.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Saccharopine reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_149838</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-saccharopine + NADP(+) + H2O = (S)-2-amino-6-oxohexanoate + L-glutamate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57951"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.10" evidence="8"/>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760176.1">
        <property type="nucleotide sequence ID" value="XM_016905802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJS3"/>
    <dbReference type="STRING" id="692275.N1QJS3"/>
    <dbReference type="GeneID" id="27902939"/>
    <dbReference type="eggNOG" id="KOG0172">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016207_3_1_1"/>
    <dbReference type="OMA" id="WNYKFTW"/>
    <dbReference type="OrthoDB" id="10059875at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004755">
        <property type="term" value="F:saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000008">
        <property type="entry name" value="Alpha-aminoadipic semialdehyde synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000072">
        <property type="entry name" value="Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1870.10:FF:000002">
        <property type="entry name" value="Saccharopine dehydrogenase Lys9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1870.10">
        <property type="entry name" value="Domain 3, Saccharopine reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051168">
        <property type="entry name" value="AASS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032095">
        <property type="entry name" value="Sacchrp_dh-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133:SF22">
        <property type="entry name" value="ALPHA-AMINOADIPIC SEMIALDEHYDE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16653">
        <property type="entry name" value="Sacchrp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Saccharopine dehydrogenase NADP binding" evidence="11">
        <location>
            <begin position="5"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Saccharopine dehydrogenase-like C-terminal" evidence="12">
        <location>
            <begin position="124"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00060549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00066976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00083134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF12055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="450" mass="49749" checksum="10DF364E688CD770" modified="2013-06-26" version="1">MTQKVLLLGAGFVVRPTLVELDKAGVQVTVACRTLDSAKKLVAGDLKHASAISLDVNDSKALEEEIAKNDLVISLIPYTFHALVIKAAIAVKKHVVTTSYVSPAMQELDQAAKDAGITVFNEIGLDPGLDHLYAVKTIDEVHKAGGKITGFWSYCGGLPAPENSDNPLGYKFSWSPRGVLLAARNTATFYQDNKKAEIEGKDLMRSAKPYFIYPGYAFEAYPNRDSTPYRQRYNIPEAETLIRGTLRYQGNPSIVQTFRDLGLLSEEPQDYLKQPIAWKEAFAKIVGSSSHNVKDLEWAVTSKTKFTDNDAKDRILAGLRWYGLFSDDKIEPRGTPLDVLCATLEKKQQYEKGERDFVMLQHKFEITWQDGKKELRTSTLAEYGEPEGSGGYSAMAKLVGVPCAVAVLLVLDGTIKQKGVLAPVTPELVEPLRLELQKKYGIELTEKTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJV8</accession>
    <name>N1QJV8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SEPMUDRAFT_146519</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 14">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765642.1">
        <property type="nucleotide sequence ID" value="XM_016903703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJV8"/>
    <dbReference type="STRING" id="692275.N1QJV8"/>
    <dbReference type="GeneID" id="27900840"/>
    <dbReference type="eggNOG" id="KOG1375">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015718_1_1_1"/>
    <dbReference type="OMA" id="WVPRSVN"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097435">
        <property type="term" value="P:supramolecular fiber organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000003">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000009">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11 14" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 14" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="16">
        <location>
            <begin position="47"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="17">
        <location>
            <begin position="246"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="422"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="432"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMF17521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="447" mass="49791" checksum="74D58EFCED0E3F7B" modified="2013-06-26" version="1">MREIVHLQTGQCGNQIGAAFWQTISGEHGLDGSGVYNGTSDLQLERMNVYFNEASGNKYVPRAVLVDLEPGTMDAVRAGPFGQLFRPDNFVFGQSGAGNNWAKGHYTEGAELVDQVLDVVRREAEGCDCLQGFQITHSLGGGTGAGMGTLLISKIREEFPDRMMATFSVMPSPKVSDTVVEPYNATLSVHQLVENSDETFCIDNEALYDICMRTLKLNNPSYGDLNHLVSAVMSGVTTCLRFPGQLNSDLRKLAVNMVPFPRLHFFMVGFAPLTSRGAHSFRAVTVPELTQQIFDPKNMMAASDFRNGRYLTCSAIYRGKVSMKEVEDQIRNVQNKNTAYFVEWIPNNVQTALCSIPPRGLKMSSTFVGNSTSIQELFKRVGDQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQEASVSEGEDDYEEEVPLEGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1QK07</accession>
    <name>N1QK07_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_149901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760266.1">
        <property type="nucleotide sequence ID" value="XM_016905841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QK07"/>
    <dbReference type="GeneID" id="27902978"/>
    <dbReference type="eggNOG" id="ENOG502SYS3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_577672_0_0_1"/>
    <dbReference type="OMA" id="DSCTHSH"/>
    <dbReference type="OrthoDB" id="3546893at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="306"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF12145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="473" mass="52575" checksum="EE8C8860A181DA0C" modified="2013-06-26" version="1">MGGLDLMVDQVSPTSPAAEHVDSPPCSPKTIASRPFDLPGATERPAIPEKISKRATVKLTSENASAMMASQSVNFPGSNVPILLPPQPADDDDDYCPLPRWEPDTSYEHITMDDDEGNCDTMPRPTLARPPSLSTIVQESSSPPPLPQSLHIDSSAKAPRERLTSPLGPRAPPAKSVLRNVTELRRMNSEVKVHRSRASRNYTRLGREASPLLPWIPTSPEAGEGQAIHREESSNSLFDFDFDSTNAGAEHQPGNAMDEIDFESLSIDIQGALAGFDDKYRYSQALNSSPPLQARRRGSDKENQDQENQQCQKQQQKQQQQKPQRPIMTQQRHSSVWDDGEKYWQQEDHHQQQQQQRANDSRPTTAGSSEKSFTPHYIVSSSSTTTTRPPARDSLARSSFYPDYDDDHHHENEDEDDQNNNNNNNKLLTRRDPRLLSTPAAGGRVVGGERKPDVVVMAATPKSLYDADGFLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKB6</accession>
    <name>N1QKB6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Copper-fist domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_58245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765756.1">
        <property type="nucleotide sequence ID" value="XM_016909462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QKB6"/>
    <dbReference type="GeneID" id="27906599"/>
    <dbReference type="eggNOG" id="ENOG502RFRX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041929_0_0_1"/>
    <dbReference type="OMA" id="CCGRKHA"/>
    <dbReference type="OrthoDB" id="5600085at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.430.10">
        <property type="entry name" value="Copper fist DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001083">
        <property type="entry name" value="Cu_fist_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036395">
        <property type="entry name" value="Cu_fist_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00649">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01090">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57879">
        <property type="entry name" value="Zinc domain conserved in yeast copper-regulated transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50073">
        <property type="entry name" value="COPPER_FIST_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Copper-fist" evidence="2">
        <location>
            <begin position="24"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF17635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="375" mass="40529" checksum="13B93FB06060897A" modified="2013-06-26" version="1" fragment="single">MDSGSEKPFKTIEVVDSRTNQVCKVACMSCIRGHRTTACGIPVCRNKIFWTVKRPGRPSNSCTCRYGATGGCKCVVATSACPHKAKKGEKRSGECRCDEQGRYCCLIEPDHWTALFALQKPTVEFCPTREDLETKQAASASVQHISPSPGHVMPNPAGVMSVPSTPGPNMPPQIMPSPYNAFTPQSSSLTPRFGVMGLGAPRHSLPDVPLDLLTWGGDVSHAPIDYPQHYSDTGNSPEPCCQTSTSSAPPLGSPQPIAQLSYSQQQPLHDLALPQAFDVPGDQNATHATVVPTTLPATQSSIFNIEKLQSDFYTYRLPSAICQSCGYGGCNCKNCPPLFQNPFDGSWAQCCGRKHAREPQTTPEPRKVPRSSGYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKR2</accession>
    <name>N1QKR2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_112900</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764998.1">
        <property type="nucleotide sequence ID" value="XM_016901003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QKR2"/>
    <dbReference type="STRING" id="692275.N1QKR2"/>
    <dbReference type="GeneID" id="27898140"/>
    <dbReference type="eggNOG" id="KOG0272">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_20_1"/>
    <dbReference type="OMA" id="LNEPICY"/>
    <dbReference type="OrthoDB" id="540662at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030621">
        <property type="term" value="F:U4 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.110">
        <property type="entry name" value="Pre-mRNA processing factor 4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014906">
        <property type="entry name" value="PRP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036285">
        <property type="entry name" value="PRP4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19846:SF0">
        <property type="entry name" value="PRE-MRNA PROCESSING FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19846">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08799">
        <property type="entry name" value="PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00500">
        <property type="entry name" value="SFM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158230">
        <property type="entry name" value="PRP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Pre-mRNA processing factor 4 (PRP4)-like" evidence="5">
        <location>
            <begin position="77"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="298"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="340"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="382"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="498"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="112"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF16877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="537" mass="58666" checksum="8D46BF344F577B33" modified="2013-06-26" version="1">MPYQVYTNTNHNAIMHPSRQAYVNDEKEDTTLDLSSVPLDTNYHLPATTIGGEAQHASTVFNEFARKRKAAALAVPTDDQRVRTELRARGHPITLFGERKEDRRERLRDLLLREQEGGAVGDDDDSMADAEEADDGDEEGEFYIEGSQDLLSARRDIARYSLPRAAQRLKRQKEESKIPVATHVKHRKAIKEKLSSVELFGSQIASERPVSLTRFAPNGELLACGDWGGTLKLLDVPTLETNLTLRGHKGMIGGITWFPGATIPGSNVASGDVNLATSAADNEIHLWSLAQDTPVATLSGHGARVCRIDVHPSGRYLASASYDTTWRLWDVNTTTELLLQEGHSKEVYSIGFNEDGSLIASAGLDSIGRIWDLRTGRTAMILEGHIGPVHALDWSCDGYRVMTGSSDGFAKCWDLRAVRETASIGAHVGGVSDLRWFKGNDGPLSTSPEKMDTIMADGDSDVATEPQPKKSGTFVVSSGFDKNVNIFSADDWALCKSLTGHDGTVLSVDVTADSKWIASCGRDRTVKLWARDAMDGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKW5</accession>
    <name>N1QKW5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Copper-fist domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_146766</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765956.1">
        <property type="nucleotide sequence ID" value="XM_016903851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QKW5"/>
    <dbReference type="STRING" id="692275.N1QKW5"/>
    <dbReference type="GeneID" id="27900988"/>
    <dbReference type="eggNOG" id="ENOG502S7CA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034573_0_0_1"/>
    <dbReference type="OMA" id="HAAHECG"/>
    <dbReference type="OrthoDB" id="5600085at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.430.10:FF:000001">
        <property type="entry name" value="Copper fist DNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.430.10">
        <property type="entry name" value="Copper fist DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051763">
        <property type="entry name" value="Copper_Homeo_Regul"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001083">
        <property type="entry name" value="Cu_fist_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036395">
        <property type="entry name" value="Cu_fist_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00649">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00617">
        <property type="entry name" value="COPPERFIST"/>
    </dbReference>
    <dbReference type="SMART" id="SM01090">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00412">
        <property type="entry name" value="Cu_FIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57879">
        <property type="entry name" value="Zinc domain conserved in yeast copper-regulated transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50073">
        <property type="entry name" value="COPPER_FIST_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Copper-fist" evidence="9">
        <location>
            <begin position="2"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="434"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="495"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="237"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="453"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="499"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="518"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF17835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="571" mass="61372" checksum="C2A5998BB29A8634" modified="2013-06-26" version="1">MVVKEDGTKWACQSCLKGHRVSGCNHTDRELTLVPKKGRPVTQCQHCRLERKKRAAHVKCDCGEAEKPHHSKEKCIHLREAEERAKAGFHDETHARQEDDPAHLTAVAEEQGCCCHHGGKCACSLMKREPTSKGSSPPHGPAVPKPRLETAKSDGSITVFKNGHHKPVHHKNHAAHECGMPYKMPLPRAHTEHNVSQAARRSVDSLPLQSASLADVPSSRPVNGLLLTNAPRRLSKSEQPSPKFTSTGTCSGGLSDNTLSMIDFGTLGPTQTNQSVDSSTNDCMAFPAFEPMSGMADSSFDPWSIGTSADPMPNNNPFAAWASQFDVSNVAQPALTAASSGTQSEIDEIPTVDDLYGFPMPSIQEDIGTLPMDTVMSETNNANRRSLPPNFFGNADFTMSQAANEWQTPVSSAYNFSMDKSKTAELDQTFTFNGWPTPPMVPGTSLPPRAAGLSTTGRPLSQSVGPSSAPSEDLMKQLFPGLDVVDDQYATTAVGPAGLNQSSKGGIGGNTPSTTTSHRTESPPSRDDFGGFVSQSWSDGSLSVPVDAFTDPYNLNGPNFSPRFDGPWTYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKZ5</accession>
    <name>N1QKZ5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Aminomethyltransferase</fullName>
            <ecNumber evidence="4 12">2.1.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 12">Glycine cleavage system T protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SEPMUDRAFT_105060</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[protein] + (6S)-5,6,7,8-tetrahydrofolate = N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16945"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10492"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="2.1.2.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the GcvT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.10" evidence="4 12"/>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765991.1">
        <property type="nucleotide sequence ID" value="XM_016900563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QKZ5"/>
    <dbReference type="STRING" id="692275.N1QKZ5"/>
    <dbReference type="GeneID" id="27897700"/>
    <dbReference type="eggNOG" id="KOG2770">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_10_0_1"/>
    <dbReference type="OMA" id="MPVQYPA"/>
    <dbReference type="OrthoDB" id="10263536at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004047">
        <property type="term" value="F:aminomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006546">
        <property type="term" value="P:glycine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.110:FF:000002">
        <property type="entry name" value="Aminomethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1400:FF:000001">
        <property type="entry name" value="Aminomethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1250.10:FF:000002">
        <property type="entry name" value="Aminomethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.110">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1400">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1250.10">
        <property type="entry name" value="Aminomethyltransferase fragment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006223">
        <property type="entry name" value="GcvT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GcvT/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GcvT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCVT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00528">
        <property type="entry name" value="gcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757:SF2">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006487">
        <property type="entry name" value="GcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="GCVT N-terminal" evidence="13">
        <location>
            <begin position="12"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Aminomethyltransferase C-terminal" evidence="14">
        <location>
            <begin position="322"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006487-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMF17870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="412" mass="44384" checksum="5288F14088FD3E49" modified="2013-06-26" version="1">MFTEENLGRTALYDLHLEHGGKMVPFGGYSMPVQYSDLSVGDSHAWTREKASLFDVGHMVQYHVEGPGAEAFLESITPSGVKELKVGQSTLSALLLPKTGGIGDDCIITRLEAGPKHLFYLVTNAGCREKDYKYLSSAISNWDNTVNPVVALRHLEADSKPYGLIALQGPLSASILQSAFATNCKVDMSKWYFGTAKYITLDLPSGESLPIVASRGGYTGEDGFELSIHPSQTVSVTRHLLNVATPSQLRFAGLGARDSLRLEAGMCLYGHDLDDTTTPVEAGLSWIIPKSRRSGERANFHGAETIIPQITPKKEGGVGVTRRRVGFIVQGAPAREGAEVLDAATEQVIGRITSGCPSPTLKQNIAMGYIKDGQHKAGTEVLVKVRGKARKAVVSKMPFLPAKYVKEALSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2023-02-22" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>N1QL07</accession>
    <name>N1QL07_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_103705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764429.1">
        <property type="nucleotide sequence ID" value="XM_016900512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QL07"/>
    <dbReference type="GeneID" id="27897649"/>
    <dbReference type="HOGENOM" id="CLU_1636459_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110937" evidence="1">
        <location>
            <begin position="20"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF16308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="162" mass="17133" checksum="F8DD215FAECA478E" modified="2013-06-26" version="1">MLLSLFITITLACFSNAQACGSITCGANEERVEIGGMLAFDDLPGLPIRPGTNVVVGWPRQGRRGLTIAYGNPTGVTIGITINSILRDTGVSFTATPAIGYTEITLDADPRHYFGHPVEILITYIPDFPPAENTIGSSFRTTPSGPSCDGKCGVKEGHLTGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1QL47</accession>
    <name>N1QL47_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mago nashi domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_146874</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mago nashi family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016766107.1">
        <property type="nucleotide sequence ID" value="XM_016903927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QL47"/>
    <dbReference type="STRING" id="692275.N1QL47"/>
    <dbReference type="GeneID" id="27901064"/>
    <dbReference type="eggNOG" id="KOG3392">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109497_1_1_1"/>
    <dbReference type="OMA" id="IRKEMWI"/>
    <dbReference type="OrthoDB" id="6495301at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11295">
        <property type="entry name" value="Mago_nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1560.10:FF:000001">
        <property type="entry name" value="Protein mago nashi homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1560.10">
        <property type="entry name" value="Mago nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004023">
        <property type="entry name" value="Mago_nashi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036605">
        <property type="entry name" value="Mago_nashi_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12638:SF0">
        <property type="entry name" value="MAGO HOMOLOG, EXON JUNCTION COMPLEX SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12638">
        <property type="entry name" value="PROTEIN MAGO NASHI HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02792">
        <property type="entry name" value="Mago_nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89817">
        <property type="entry name" value="Mago nashi protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF17986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="155" mass="17960" checksum="C343C39041449DED" modified="2013-06-26" version="1">MPESTGEPFYVRYYSGHSGRFGHEFLEFDFRVVGDGRSAIARYANNSNYRNDSLIRKEMCVSALMVQEIKRIIKDSEIMKEDDTKWPQKNKDGRQELEIRMGGEHISFETAKIGSLVDVNESEDPEGLRVFYYLVQDLKALVFSLISLHFKIKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1QLL7</accession>
    <name>N1QLL7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_129507</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764714.1">
        <property type="nucleotide sequence ID" value="XM_016902288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QLL7"/>
    <dbReference type="STRING" id="692275.N1QLL7"/>
    <dbReference type="GeneID" id="27899425"/>
    <dbReference type="eggNOG" id="KOG1209">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_9_1"/>
    <dbReference type="OMA" id="GGTPDWF"/>
    <dbReference type="OrthoDB" id="2102561at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000140">
        <property type="term" value="F:acylglycerone-phosphate reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000261">
        <property type="entry name" value="NADPH-dependent 1-acyldihydroxyacetone phosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169:SF15">
        <property type="entry name" value="CHAIN DEHYDROGENASE_REDUCTASE (AYR1), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF16593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="280" mass="31405" checksum="DAB1E531D5E37606" modified="2013-06-26" version="1">MSKSVLITGCSKGGIGHSLAREFKKNGLRVFATARNADSISDLAQQGIETLSLEVTEQDSINALKAEVESRTGGRLDYLVNNAGRNYTVPALDVEMEEIRLTFETNLFAVMRMCQTFAPLLINAKGTIVQIGSVAGIIPYVFGSVYNASKAALHSYSNTLRVELEPFDVRVVTIVTGGVKSNIARTTRTLSQDSYYFPVETEYKERLTHSQAQGVPNEDYSRRVVHAVLNKPNKDHFWEGGKAWLVWWASTFLPRWVMDSVLSRMFKLWKLRGTYQKKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1QM58</accession>
    <name>N1QM58_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Spc7-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_146079</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765084.1">
        <property type="nucleotide sequence ID" value="XM_016903443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QM58"/>
    <dbReference type="STRING" id="692275.N1QM58"/>
    <dbReference type="GeneID" id="27900580"/>
    <dbReference type="eggNOG" id="ENOG502S20P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002533_1_0_1"/>
    <dbReference type="OMA" id="WRMKLQE"/>
    <dbReference type="OrthoDB" id="5592879at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990758">
        <property type="term" value="P:mitotic sister chromatid biorientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040850">
        <property type="entry name" value="Knl1_RWD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033338">
        <property type="entry name" value="Spc105/Spc7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013253">
        <property type="entry name" value="Spc7_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28260">
        <property type="entry name" value="SPINDLE POLE BODY COMPONENT SPC105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28260:SF1">
        <property type="entry name" value="SPINDLE POLE BODY COMPONENT SPC105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18210">
        <property type="entry name" value="Knl1_RWD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15402">
        <property type="entry name" value="MELT_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08317">
        <property type="entry name" value="Spc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00787">
        <property type="entry name" value="Spc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01315">
        <property type="entry name" value="Spc7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spc7 kinetochore protein" evidence="3">
        <location>
            <begin position="717"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="476"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="928"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="124"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="138"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="421"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="486"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="564"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="588"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="648"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="694"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF16963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1229" mass="134845" checksum="49DD4051CF5A8BF2" modified="2013-06-26" version="1">MADKENVAPVTSSDPLQRLSALSPSLKKATRKGRSKSIGPGALDEPEAPKLSARDRRKSAFVPAAKSILSKDEESARAARRKSMANRRVSFAPEATLHTWDIVMDQHEHTTSTDSDSTTRRASHFSSASDSDAAIYAQEEEDRELLESEDDMNSKRSRRSSGIPPMNFNNPEDTYSSGTSGSEDGSGSDNGEDDASDDEGTAMSLSVDDPTLESHADSEGSTGSSERLEASLKAAARLAGTRGIEYDEFGDMSMEVADEEVTNAMQPWALRNGLEKIGSASLDQENVNPFSPAFSEVVTAQQGTVTGEETQDMSMDVTRAVGGIMNASRFAGPQSSPRSEGDETMDLTQAVGRIAGQKRRRSTTEHGSPGVVVAPVLSKRKRPSATRTSMGDDTMDLTMAVGGIQSTAIPDRRRSLRGRRSSGMGSDTSDATMDITHAVGSIVPVLTDITENSFAGDEELSMELTTVIGGIRELSRPMSKDGSRLGTPQSTQSSQPLGTVNTTLNGQEPFMNTPDLVAKQPLEPMMESAKQASPPAPVREAMSPMRLSRSPRQFGSPAPPRQHLGSSTQSKSRSPGRDEVTYPELPPLTQNSSPVRTPSSTPQQRQGRSNIVSEERQSNIHVEAPNQSPTKPKQRGPSSKEFISTPEKLNESQDDTRTLHDSLKLMTTPRKETLKHATPKKTPARPLSPAKPNTPRGRPTPRGSVTILPSPVRHLREDLERIRVTGGPQQKIGLQEFLAKAGIRFMDLTTTKRRLTVAPPSKTKGHTQSETEVVSLEDGVVAAACTVPELELYQHACLELKRFTKEGKQVITELEDQTLRAQPPLVQSYAHAPPDRKLTLDAQMRDMKTNARLRSKEMWYAWRSQLLEELMGGLSKIGEGLIRDDETLAHAEEVLDQALPPLLTQHASLRQDAAQLERTANAVPEGEKEQLSNTRESLTIVNAELAEKRVLLERLRKEVEEQESTIEHLQESKVEFAAAIEEANRVRETCRGISIDEITALQESVRKLEKRYSWSISSASVEPEALTMTYKSDIQLFFNPKAFKTLTSNIEARIPNAPISLTYIANDRKPLSTTLRFFLQLLRASLQGLPQATTRVTNLLELVSSGWDTALQVSETERRLSIETLTTSRIMGDECLEIAAEVLLPQVRTKVRVAFALDAKTEEIDGPGKLGLSTAITPRVYVVYGEQYNEHNMTQYLKQSIDGHENWDEGVRLMREKLIARGPKGGARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1QN70</accession>
    <name>N1QN70_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">proline--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Prolyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_146832</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Pro) + L-proline + ATP = L-prolyl-tRNA(Pro) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="2"/>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016766048.1">
        <property type="nucleotide sequence ID" value="XM_016903894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QN70"/>
    <dbReference type="STRING" id="692275.N1QN70"/>
    <dbReference type="GeneID" id="27901031"/>
    <dbReference type="eggNOG" id="KOG2324">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016739_0_0_1"/>
    <dbReference type="OMA" id="NCDYAAN"/>
    <dbReference type="OrthoDB" id="10267474at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050062">
        <property type="entry name" value="Pro-tRNA_synthetase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42753">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME PROTEIN L39/PROLYL-TRNA LIGASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42753:SF2">
        <property type="entry name" value="PROLINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="10">
        <location>
            <begin position="1"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF17927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="487" mass="54168" checksum="BAA9E206FFF10A88" modified="2013-06-26" version="1">MQSVGASKVSLSSLSSTELWEKSGRLDGRNKELFQLEDRKEAKFLLAPTHEEEITTIVKNAVHSYKDLPLRLYQVTRKYRDEVRPRQGLLRGREFVMKDLYTFDLTSKQAMETYSAVSGAYKACLDELKLPYLVATADSGNMGGTHSHEYHFASAKGEDTIVTCESCDLSMNEEVCFGKYRPHELDGSSYTLWSGRTTEVRDGRTRTASLVNIYLPHGDHEVNIHALRKSVPSLDPAPYSLHDWYDECKELLNTEGLHVPSVISIRDPRVQSEDSTVRSSRVQTAPFLLTKIRQGDPCPSCDTGSVHLQQAVEVGHTFHLGTRYSRALEAAVQAEDNSQVDIEMGCHGIGVSRLIGAVASLLADQNGLNWPLAIAPYSILLVGAGRSSAEDVQGLYDTLMTSLLQQFLSGPRTRSIAPDAIIDDRDRSFGWKLNDADLIGYPFVVVLGKAWNQTEKAVELQCRRLGVKETVPVTELAQRITQYSAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNG5</accession>
    <name>N1QNG5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP synthase subunit delta, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">F-ATPase delta subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SEPMUDRAFT_57501</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765390.1">
        <property type="nucleotide sequence ID" value="XM_016909438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNG5"/>
    <dbReference type="STRING" id="692275.N1QNG5"/>
    <dbReference type="GeneID" id="27906575"/>
    <dbReference type="eggNOG" id="KOG1758">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084338_0_0_1"/>
    <dbReference type="OMA" id="PHQTIYR"/>
    <dbReference type="OrthoDB" id="270171at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.15.10:FF:000003">
        <property type="entry name" value="ATP synthase subunit delta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="entry name" value="F0F1 ATP synthase delta/epsilon subunit, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048938">
        <property type="entry name" value="ATPD_C_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822">
        <property type="entry name" value="ATP SYNTHASE DELTA/EPSILON CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822:SF7">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT DELTA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21334">
        <property type="entry name" value="ATPD_C_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="Epsilon subunit of F1F0-ATP synthase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP synthase F1 complex delta/epsilon subunit N-terminal" evidence="14">
        <location>
            <begin position="37"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="F1F0-ATP synthase subunit delta C-terminal" evidence="15">
        <location>
            <begin position="123"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF21334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMF17269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="166" mass="17612" checksum="EAC2F2E76EED6B6E" modified="2013-06-26" version="1">MNSLRLARSAVRAAPSAFRAAPALRRGYADVASDKIQLTLALPHQAIYKSKDVVQVNIPAESGEMGVLASHVPSIEQLKPGLVEVIEEQGGSKQFFLSGGFATVQPNSVLSINAVEGYPLEAFSAEAVRNQIAEAQKIASGSGSEQDIAEAKIELEVLETLQAQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNQ0</accession>
    <name>N1QNQ0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Basic proline-rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_146853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016766079.1">
        <property type="nucleotide sequence ID" value="XM_016903909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNQ0"/>
    <dbReference type="STRING" id="692275.N1QNQ0"/>
    <dbReference type="GeneID" id="27901046"/>
    <dbReference type="eggNOG" id="ENOG502S9W4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046290_2_0_1"/>
    <dbReference type="OMA" id="KYNESYP"/>
    <dbReference type="OrthoDB" id="5400063at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="242"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF17958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="381" mass="41165" checksum="61E1A0FAD58413AC" modified="2013-06-26" version="1">MATTSINTAPATATTYVFHSGDRGHDGFAEPESPVEGHRSGSIDSLDSLALPKLRPETSLIATEPSTSTLPQGYFNSTKNVALPVTVSRNRSPYSRTHLRSRSSGATLSAPVMTRAHSSPAAHSANRTLELHTLSTGALTSSSPMRSPARQRSPFRPAEEASYNPPPPPRSPGWFESPSAGGAIEAIQEDSELDITPRQTTPTYAMPFVRSSSLRRRPASPLHNVTNATPSTSMPGSHLENSSISVASSRSSSPSLGPLRFNETYPSLHHYASTSSLFSIPSSTPTSQRSRSPSISSLDTIEDAPDMEQEAIEADRIEKLKLAAERAAKGEEDDDSPRRRSSLDGPRGFGFNRGGNRERKRWSVCGGERRVDLDLDTIWED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNR2</accession>
    <name>N1QNR2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor CWC22</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Pre-mRNA-splicing factor cwc22</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_122861</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC22 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765620.1">
        <property type="nucleotide sequence ID" value="XM_016901803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNR2"/>
    <dbReference type="STRING" id="692275.N1QNR2"/>
    <dbReference type="GeneID" id="27898940"/>
    <dbReference type="eggNOG" id="KOG2140">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2654">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006308_0_2_1"/>
    <dbReference type="OMA" id="ILTEDMR"/>
    <dbReference type="OrthoDB" id="3938623at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000004">
        <property type="entry name" value="pre-mRNA-splicing factor CWC22 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050781">
        <property type="entry name" value="CWC22_splicing_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF3">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC22 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="MI" evidence="10">
        <location>
            <begin position="434"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="394"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="637"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="64"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="648"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="675"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="810"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="835"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="849"/>
            <end position="858"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF17499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="899" mass="102612" checksum="207512AC62B48289" modified="2013-06-26" version="1">MAAVESAVRLPTPGPGDDTAAAESVSRKRTSISRSPSPRRDAPALRRRSLSRSPLPRNTGPLPRDVDRARAKERARQLEMRQKEDDEKPAKPLTDEEKQAVAKAEYDKLLNMRSGGTYIPPARLKALQAQITDKTSKEYQRMAWEALKKSINGLINKVNVSNIKHIVPELFNENLVRGRGLFCRSIMKAQAASLPFTPIYAAMVAIVNTKLPQVGELLINRLIIQFRKAYKRNDKSVCHSSTTFIAHLINQQVAHEMLAAQMLLLLLHKPTDDSVEIAVGLMKEVGHHIEEMNSSIALAVYDQFRGILHEADIDKRVQYMIEVLFQIRKDKYKDHQAIKEELDLVEEEDQITHRPSLDDDKLKTEDGLNIFKVDPEFEANEEAYKKLKAEILGEVEGSDDEDEQSSASSSEEDDDDAEEKALEIKDQSNTDLVNLRRSIYLTIMSSGTFEEACHKLMRINLPTGREDELPSMIIECCSQERTFNKFFGLIGERFCKLNRLWKELFQEQFLKYYETIHRFETNRLRIIAQFFGHLLSTDAIDWTVFQVIKLNEEDTTSSSRIFVKILIEELEAGLGMKKLVARFQDDGLQTALTGMFPTDDPKNTRFSINFFTAIGKGPLTEGMREWLKNMPKSIPAPLPAARSQSPTRGRSASVSSYSSYSSYSSYSSRSDLRSRSRSRSRTPPRRGRDRSYSRSPTPRSNGKRAMSLSRSPTPRRRRSASFDSRSPPRRRRRDSDSLSRSPPRRGRRDSYSDRSISRSRSPPRRRRDVSSRSRSPPRRANGKGRAPSESPSPSPRRRGRTQSRSVSPPRRNRSRNRRSFSHSSPPRRDTSRSRSPPRRVPIARRRRNTSSPETSRSRSPPRREAAAVPAVARREDDQSHIHPSRRNMIPRGDGGMRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M3ASY1</accession>
    <name>M3ASY1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxymuconolactone decarboxylase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_136741</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756740.1">
        <property type="nucleotide sequence ID" value="XM_016902795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3ASY1"/>
    <dbReference type="GeneID" id="27899932"/>
    <dbReference type="eggNOG" id="ENOG502SAR1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065389_0_0_1"/>
    <dbReference type="OMA" id="ADQLYLH"/>
    <dbReference type="OrthoDB" id="5537330at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052999">
        <property type="entry name" value="PTS1_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28180">
        <property type="entry name" value="CONSERVED MITOCHONDRIAL PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28180:SF5">
        <property type="entry name" value="DNA POLYMERASE ALPHA SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF08619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="243" mass="27397" checksum="5380BBC192880190" modified="2013-05-01" version="1">MARTTPTPSETTSLFHTIEHDFPSSSLGPNKWYILLLAALTAGGHPGKAADLYTYLISSRPEFEKSEQRQNLMKRLRETLVKLVPIVGVVKPLEAVFCIAEIERPEDRDGSFSRENWSSGPLNSQRGSAWLAQIYQHNHAATESVLSHHKDFEWISREITYGLFLSDHTILGPVETEIVVLAGIAMQNLPRETGWHLRGMRRIGVAIEDVELVQRCVERVAEYCGLVLDRIPRVADVEHEVAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M3AT11</accession>
    <name>M3AT11_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ferric_reduct-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_167036</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756775.1">
        <property type="nucleotide sequence ID" value="XM_016908273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AT11"/>
    <dbReference type="STRING" id="692275.M3AT11"/>
    <dbReference type="GeneID" id="27905410"/>
    <dbReference type="eggNOG" id="KOG0039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010365_2_0_1"/>
    <dbReference type="OMA" id="GHQWGYE"/>
    <dbReference type="OrthoDB" id="167398at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="356"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="386"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="566"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="Ferric oxidoreductase" evidence="9">
        <location>
            <begin position="252"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="488"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="494"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF08654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="687" mass="76851" checksum="D67E851285AC6CDE" modified="2013-05-01" version="1">MAGITMYKPPCAQACRDSVSPYSLNCNDTNPSHMEKRHHPAKETPECYANNDRFLQSVAYCISQHCQDVEIWKIERWWTTKMPGTKPGQPEPKESYQQTLARVMTPPNVTIPTDQVLMDENTLVDEETWLAHYNSDLIFEKNEATHVRYGLVLLTTGAALPIALSLLRFVPFPRPFVSRFKARFIDPPAFGGNHNTPWLKTFIVPTRGQALFIAYLWIINVILCSVGYESRRPNSGYETRGLEIATYISYRTGVLSFSNFVLFVLYAGRNNVLIWVTSWSHGTFVLLHRWLAVICTVEACVHSALLLHIYSTNPITFDYAKETTSSYWYWGVVATIGMCVILATSILPIRQKIYEIFVTWHIIAAFIVLMAAYWHVVEAFGHQWGYETWIIIAFGCWGFDRLMRIVRIAKNGVRTATITVIDEDYIRLDILGVTASGSAYLYFPTLTWRVWKNHPFSVAISIAHTAHNASRRLSEMSLPSAVVQASEKLKAPEIQSSSTDRGTSPIDSARLNRSQQPPLQVGLSFFIRTHKGTTPMLRTRKTLPVLIESSYGHNVFGDYGGGNLAAYPNLICIVGGIGITAILPFLAGHIGRTKLYWGVSKAPLVEALHDTLAEPAFAGVEVEVTTGQRMNLQAILHKEIRADAGAGTMIVVSGPSGMADRVRLLTSKYAAEERGAVIAFVQESYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M3ATB7</accession>
    <name>M3ATB7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cu-oxidase_3-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_144577</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756880.1">
        <property type="nucleotide sequence ID" value="XM_016903078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3ATB7"/>
    <dbReference type="STRING" id="692275.M3ATB7"/>
    <dbReference type="GeneID" id="27900215"/>
    <dbReference type="eggNOG" id="KOG1263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006504_3_2_1"/>
    <dbReference type="OMA" id="SFWIRAI"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13854">
        <property type="entry name" value="CuRO_1_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13880">
        <property type="entry name" value="CuRO_2_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13901">
        <property type="entry name" value="CuRO_3_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000021">
        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000038">
        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF502">
        <property type="entry name" value="MULTICOPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="54"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="7">
        <location>
            <begin position="182"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="404"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF08759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="551" mass="60377" checksum="2C00BAA9E8991A92" modified="2013-05-01" version="1">MSGIMQCGDVAVRQSACTGNTADDRSTWCDYDTSTNYYDEGPDTGVTVEYWFDIQNVTLAPNGVERTYLTVNGSLPGPTIIANWGDTIVVHVTNSLDINGTTVHFHGIRQNFTNPYDGVPSITQCPTAPGDTMTYTFKATQYGSSWYHSHYAMQAWDGVFGGIIINGPATANYDVDLGNLFLMEWDHLTASQLYSYVQYTGPPVADSGLINGTNMNDTLGSYWEQTVTSGSSYLLRVVNAAIDTHFDFSIDNHTLQVIASDFVPIVPYTTTSISIGMGQRYDVIVTANQASIASDFWLRAIPDTFCSTNYNPDLIKGIIHYDDSTATPTTTAYTITENDCLGEPSASIVPFVALTASTAADVSLDDEVTVEAGDIETGVVEKWFLGDVNFVVNWKQPTALLVVEGENTYNESYAVTEMPTKDTWMTLIIEQTFPLPHPIHLHGHDFFVLASGSGTYADSNAVLQTENPPRRDVQMLPAAGYLVIAWQADNPGVWLAHCHIGWHTAEGFALQFVERYDEIAGLYNSTELEDSCEAWSTFQTSAGILQDDDGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M3AVK2</accession>
    <name>M3AVK2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3'-5' exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_151139</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758212.1">
        <property type="nucleotide sequence ID" value="XM_016906624.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.M3AVK2"/>
    <dbReference type="GeneID" id="27903761"/>
    <dbReference type="eggNOG" id="KOG4373">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_248815_0_0_1"/>
    <dbReference type="OMA" id="EMIRSTH"/>
    <dbReference type="OrthoDB" id="1920326at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06141">
        <property type="entry name" value="WRN_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051132">
        <property type="entry name" value="3-5_Exonuclease_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620">
        <property type="entry name" value="3-5 EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620:SF104">
        <property type="entry name" value="EXONUCLEASE 3'-5' DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="4">
        <location>
            <begin position="1066"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="95"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="850"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="989"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="101"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="861"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="915"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="937"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="989"/>
            <end position="999"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF10091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1498" mass="168138" checksum="6824BCB97DA5C1A3" modified="2013-05-01" version="1">MLSNTPIFADVAFRLRSGHVSAGEMASMASGLESATTAIISSPRLPSTRPLSHRWDRSRGLVLERASRRIRTDRTWKQGNGMYALPASKRSYATRELGRPSGSQRTTATGTTSYVDNPHRVPGFTGASPQQIEQLARKVKKLEGEASQRQYEFDKLKDSIKSKDVILEQREFVLQDSLQQLDQARRAHKKELEKLLAAHWKESEKLRVAHQKESEQLRAAYQKESEQLRAAYQKESEQRQTEQQKEVETLQQSLRQEQEAGRLELQTAIEKHAQELQEMRDSAQAEQDRVLQLSASGLDENAPILQVVRSEVEDEARQRFDKQLYEIEHRHKLALSHEKAVRAELEKWKDRAEKDNQLRAGRESTVLTHLKDQVDALRREKNAAVVDSNTERLRNERLRKTVAESQKLIEGRKARTEESRRDYFGYRELFHSMGDQIYETLGGATSIEEDLEREALLWRKSAQVFQKNRELLLFRQNSTYDTLQRTINEFLEGRAIAAQAAASNVRQRSGKLLEARKSLNLQGHASRMVTNYLHFEAEPTHARAVSVVHYMSLVLPFKQRLEYCHGQITDVAARIQKLQDMSSEVSTELERKLTMLKARRELLGEFLKYAEAFRVREAMAALLNGSAEDRITFVRTRAVHDRFRTLTNVIARNESDHSLEAIGRQLSRARGLITQQENFVRSRLIAQQDLGQLDQTLVEEADSEIRRRLKIHNHEADVALDVIVRQRRSLAKNMRERKMKLRKVATTVGRSSSTVNDLAVTDLAKNMRERKMKLRKVATTVGRSSSTVDDLAVTDLPLATENPGLARANRVVRRRHTRKSRVHIRLALHVRPPEKLSALDAENISASAGAGRLNFTPTPPMQSSHFPSPHSLSKSQEQVSRWSTLGNALRTQSDTNSGHVAVLKPSGRKDAAESAESQSVAMTTSVDQSAHKEDAQTSKTLTRQSSTATSTPPAKAHASPLGPQEHAMSHAGIFSRDHLVDSDAVSIPSSLSSYVPSDNDSAEADVAPGSPAAEDASAVTPEPHTILDYQIPQKAYREAVMASTSSNAAFWTHQLYKSSEGKSPIVYYCKNLDTAERQCKLFLKEPVLGFDLEWEMNSTLGKSPIKKCVSLIQLASEDKICLIHVACFAGETAEQLLPPSLKTILEDVRVVKAGVHINNDAQRMRRCFDVDMKGIFELSHMYRLVKTPDAVSFKLVKLAEQVQDTLLLPLKKDDVRVSAWSKSLNAQQCAYAAADAYAGFRLFHQLDNLRKDLRPTPPRPAFFETYQPIILGDGTIIERATTRPKKAVKKSAAVLGDAHESDDEYHDALEELPNTYELGAAALQDGKVDIDEADPESVAALREVMEKTYLRGSPSSVDSQTSIDAGSNTTVNAIPTQAMPKSESKPSKPASHVLVASPETMLADMWIDSLASRNPKVGAASLRAYHLWHHQNHSLDAVAGLCRQPPLALTSVASYIMTAIKEEDMPYDKDRLKEAFVHLPKSVWHVYGKWVKELGLDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M3AVT1</accession>
    <name>M3AVT1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_71351</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyltransferase family. GNAT subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758307.1">
        <property type="nucleotide sequence ID" value="XM_016909936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AVT1"/>
    <dbReference type="GeneID" id="27907073"/>
    <dbReference type="eggNOG" id="KOG4135">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073102_0_0_1"/>
    <dbReference type="OMA" id="HETHDIQ"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039135">
        <property type="entry name" value="NAT9-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13256:SF16">
        <property type="entry name" value="ALPHA_BETA-TUBULIN-N-ACETYLTRANSFERASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13256">
        <property type="entry name" value="N-ACETYLTRANSFERASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="5">
        <location>
            <begin position="14"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="72"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="100"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF10186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="305" mass="33393" checksum="8A509C1CBB4264A2" modified="2013-05-01" version="1">MKINEHTALSSRSILLVPYSPHHVPTYHQWMQDPDLQAATASEPLSLEEEYAMQRSWRLDSDKLTFIICRPRDETSSSSSSSSTTTTTTTTPGSSSSSSSDREKETQEEKVQKDQITATKDDSPDRMIGDINLFLFPLDSSSSPSPPSPPSSEAIPPPPPPPKILGEIEIMIADKSSQRKGHGKTSLLIFLDYILEHWSLIGREFSSSFSSSSSSSSDPSTSFSAAAAAISPQLAYLRVKVHETNVGSIRLFESVGFQRVSETANYFGEIEMRWYTTGDGDGGGHTGGEKARELPYRMEAVTESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M3AWG0</accession>
    <name>M3AWG0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DnaJ-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_150104</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759206.1">
        <property type="nucleotide sequence ID" value="XM_016905965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AWG0"/>
    <dbReference type="STRING" id="692275.M3AWG0"/>
    <dbReference type="GeneID" id="27903102"/>
    <dbReference type="eggNOG" id="KOG0724">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019916_1_0_1"/>
    <dbReference type="OMA" id="RNHTWSE"/>
    <dbReference type="OrthoDB" id="1690618at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101031">
        <property type="term" value="C:protein folding chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051083">
        <property type="term" value="P:'de novo' cotranslational protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006452">
        <property type="term" value="P:translational frameshifting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23953">
        <property type="entry name" value="zuotin_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.840">
        <property type="entry name" value="Ribosome-associated complex head domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032003">
        <property type="entry name" value="RAC_head"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042569">
        <property type="entry name" value="RAC_head_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054076">
        <property type="entry name" value="ZUO1-like_ZHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044634">
        <property type="entry name" value="Zuotin/DnaJC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058871">
        <property type="entry name" value="Zuotin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43999">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43999:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16717">
        <property type="entry name" value="RAC_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21884">
        <property type="entry name" value="ZUO1-like_ZHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26185">
        <property type="entry name" value="Zuotin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="5">
        <location>
            <begin position="100"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="245"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="253"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="269"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF11085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="443" mass="50443" checksum="612308D79896BDC2" modified="2013-05-01" version="1">MAAVQITAALPTLPEGWTAEKDFKVVGQLSAPTQRALEPVGPHYLAHARRKRHRRTFSEDEKLQAEQNVKKVEQVVNDDIDEVTDPMLLNREAKDWKQQDHYAIMGLSKFRYKATEDQIKRAHRKAVLLHHPDKKAAQGQSENDQFFKCIQRATDILLDPVKRRQFDSVDEAADREPPSKKDVQKKGFYKAWAPVFEAESRFSKVKPVPKLGNESSTKEEVEAFYNFWYSFDSWRSFEYLDEEVPDDNESRDQKRHMERKNNNARKKRKNEDVQRLRELVDQALAADERPKKFRQEKNKDKNAKKAAAEAADKAAKEEALRKKEEEAAAAKEKEASEKAAREDAKKGKEAAKNAAKKNKRVIRQAPKDVSYFADGEPSAAQIDGVLNEVDSVILKLDNEEIAELAAQLNGKKDKTAVKGVFSAQVEKLVSAGKAKEGDYKNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M3AWZ5</accession>
    <name>M3AWZ5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_150229</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759371.1">
        <property type="nucleotide sequence ID" value="XM_016906033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AWZ5"/>
    <dbReference type="STRING" id="692275.M3AWZ5"/>
    <dbReference type="GeneID" id="27903170"/>
    <dbReference type="eggNOG" id="ENOG502S19D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074138_0_0_1"/>
    <dbReference type="OMA" id="TQEMKPR"/>
    <dbReference type="OrthoDB" id="7763451at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343:SF10">
        <property type="entry name" value="RNA-BINDING REGION RNP-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343">
        <property type="entry name" value="SERINE/ARGININE-RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="3"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF11250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="310" mass="32681" checksum="427893CE5E877D8C" modified="2013-05-01" version="1">MSTTVHVKGISAQTSEKEVRDFFSFCGKIQSLSLTPESNDSSASQSASVTFEKETAAKTALLLDNTQLGPSQVHVTAGQTLEQASGGKTAGASEDDLAQEDKPRARVAAEMLAHGYNLSDQVIQKALALDQQHGISTRFTTALQNFDAKYKVSEKAKTTDTQYGISAKANEGWKGFNSYFEKALGTPTGLKVRQFYEQGSKQVLDVHNEAKHLASLKAGKEPNHPVEGKEGRTACACGSAAAKCSCKPGECACSSCSKNPDEKTSTVSAEEAELEKIPGTEKTKCNCGGADAKCACEAGKCACASCPKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M3B1Q3</accession>
    <name>M3B1Q3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">U6 snRNA phosphodiesterase</fullName>
            <ecNumber evidence="5">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">USB1</name>
        <name evidence="7" type="ORF">SEPMUDRAFT_41855</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 2H phosphoesterase superfamily. USB1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="5"/>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761853.1">
        <property type="nucleotide sequence ID" value="XM_016908845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B1Q3"/>
    <dbReference type="STRING" id="692275.M3B1Q3"/>
    <dbReference type="GeneID" id="27905982"/>
    <dbReference type="eggNOG" id="KOG3102">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050234_1_0_1"/>
    <dbReference type="OMA" id="FHVSIGW"/>
    <dbReference type="OrthoDB" id="49151at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990838">
        <property type="term" value="F:poly(U)-specific exoribonuclease activity, producing 3' uridine cyclic phosphate ends"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034477">
        <property type="term" value="P:U6 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03040">
        <property type="entry name" value="USB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027521">
        <property type="entry name" value="Usb1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13522">
        <property type="entry name" value="U6 SNRNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13522:SF3">
        <property type="entry name" value="U6 SNRNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09749">
        <property type="entry name" value="HVSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="1 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF13732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="286" mass="32823" checksum="371A742109E0917A" modified="2013-05-01" version="1">MGLVDYSDSDGDDEAEPARKKRKPATVKDQLPPLPAAFRDLYSSTVRTSTHDDPSLHEGRKRVTPHIAGNWPTHVYLDWTPQPHDYRSLQDLITHAQKTTNCKDDIHSLLENDLGVRQPLHVSLSRPLALKTEHKDTFFDRLKTSISLAGVSAFSVRPLDLVWHPNEDQTRWFLVLRLRRPSCDELRILLERSNDLARQYNQPLLYGHRTFSSSHVPEAWEHDNFHISIAWSIQPHQKSASAGPVEVVISDQLLQKLKASDLTFREVKVRIGQDVHSIPLRQARKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M3B2J7</accession>
    <name>M3B2J7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Non-homologous end-joining factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_115282</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the XRCC4-XLF family. XLF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF13987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762108.1">
        <property type="nucleotide sequence ID" value="XM_016901145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B2J7"/>
    <dbReference type="STRING" id="692275.M3B2J7"/>
    <dbReference type="GeneID" id="27898282"/>
    <dbReference type="eggNOG" id="ENOG502SCQK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022898_0_0_1"/>
    <dbReference type="OMA" id="IKGVAPF"/>
    <dbReference type="OrthoDB" id="2155935at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032807">
        <property type="term" value="C:DNA ligase IV complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045027">
        <property type="term" value="F:DNA end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22285">
        <property type="entry name" value="HD_XLF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.210.10">
        <property type="entry name" value="DNA double-strand break repair and VJ recombination XRCC4, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052287">
        <property type="entry name" value="NHEJ_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053829">
        <property type="entry name" value="XLF-like_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015381">
        <property type="entry name" value="XLF-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038051">
        <property type="entry name" value="XRCC4-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32235">
        <property type="entry name" value="NON-HOMOLOGOUS END-JOINING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32235:SF1">
        <property type="entry name" value="NON-HOMOLOGOUS END-JOINING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09302">
        <property type="entry name" value="XLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21928">
        <property type="entry name" value="XLF_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XLF-like N-terminal" evidence="9">
        <location>
            <begin position="6"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="XLF-like coiled-coil region" evidence="10">
        <location>
            <begin position="132"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="271"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="335"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="343"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="551"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF13987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="611" mass="67426" checksum="241D698B9E0618FF" modified="2013-05-01" version="1">MTIVRPWKSLAIEGDYPPLFLKAHLDAGRCALELTDLNRLWSGCLSRDELLKSASDQGTSIDPSEDDDQYHQFLSKFNSALNGEPSTTVHLEPLGAQDGLMLSISAPLPGSLPTFEWTMQLRRVDNDDSCVFKNTVLTPLLVHANNLMSQVRYLIAELGHKDRVIGKIADKLENIGQDLGQVFPGASNPRSTKATKRAQLASHVEGLAEFDPRKWQAAGTKDTEEDLSVDTMNTILANLPEAGLINAHKDTHGIWWRPRSAPVLHDYDSTEDDTGFGTAGCQSPLLHKNKDGTHPAMQGSEENDGIRQQLTAPSFPTDEETEDEDDLDAPCQRAAQPEVFPQHDSSTSRTLSYGRASSQSQQVTDNRAQDVQLSSGQQLRIPGGKISEHPQQRSDEVAHESREARVVPPSSTHQADPDAGDFAGRLRSQTPGLDSNSVKAELFNSSPAKPDQPRRKLGAFGRKTRSSPTPDREPVADSTPGHGQGLDNLERDATMPFSQPADADHASHGRTKPRVGIFGSRRQNESQNAQADADAAIESSQKSPLETEEASPVHHMTETEDRQSRTQVRSEKVEQQGREESEERANIRREKLKRDIAEKSREPVKKKKRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>M3B428</accession>
    <name>M3B428_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_124676</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762648.1">
        <property type="nucleotide sequence ID" value="XM_016901931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B428"/>
    <dbReference type="GeneID" id="27899068"/>
    <dbReference type="HOGENOM" id="CLU_2028190_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF14527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="122" mass="14328" checksum="C7980F86F857F926" modified="2013-05-01" version="1">MPGCFVPAEAFPGYPGRSGLHQIPQTSRRQAAAYAVVAECDPRRDKSMRRVSFQANRNCWSKAWIKRSTRLAAWCFRHRFPQDQNRRIAFGMSTRRRPLHGAWQPRGVVIVVVVCCQWWRWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M3B691</accession>
    <name>M3B691_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_105600</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763443.1">
        <property type="nucleotide sequence ID" value="XM_016900584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B691"/>
    <dbReference type="STRING" id="692275.M3B691"/>
    <dbReference type="GeneID" id="27897721"/>
    <dbReference type="eggNOG" id="KOG1867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_627260_0_0_1"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF758">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="76"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF15322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="437" mass="49374" checksum="AF69F619BFF3654B" modified="2013-05-01" version="1">MASTGGKKRATSEESKSPRPSKTSKSPGRDAASTPHLLKLKGMMQKDGKDHRRIQPESNLTGLTSQFPDIGYPYSKGLVNEDTNCYRNAVLQGLFHIPAFYRYMGKLHQDCPIKSTRCFVCRLQYLCWYYWNTTGTWKGSEDHGLFCVSETLCRSIHRSMELDANAPVNLISLREGIQDGAQCDAREMLEYIIADQILAKLGPPDFVTYNDMFQLMLKTSWTCQDCGRTSDTIAPCPEIGILLPMAIAGMQDDRSLDWCLQPYFAFQRRTHCADLNCHHASRIRDPNPSGPERNVTSTILQAPEILFIHFLRFDQVWNARRHRMDEKKVFYRIKFPEQLDLSQFGAAGVSGQGLKYRLDAVVAHGGRTITRGHYIAACRTHPNDPLGDKFQVIDDDNSIASPRGGGIEDARRPLSANNQEFEPQMLMYSKIHVADGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M3B751</accession>
    <name>M3B751_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PEBP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_154435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763793.1">
        <property type="nucleotide sequence ID" value="XM_016907562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B751"/>
    <dbReference type="STRING" id="692275.M3B751"/>
    <dbReference type="GeneID" id="27904699"/>
    <dbReference type="eggNOG" id="KOG3346">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094644_1_0_1"/>
    <dbReference type="OMA" id="VGPPHFA"/>
    <dbReference type="OrthoDB" id="2506647at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF82">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004031379" evidence="1">
        <location>
            <begin position="38"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF15672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="275" mass="30216" checksum="552A4DC8BD88762D" modified="2013-05-01" version="1">MPPIAPSQASYTSIPSLTAFTMLFSIFALAAVSAAAAVPDAAHLDARQTCRIATQAELQAARDAFLREEIIPPTPAQFDRSTPNLIPDFRPKSALSVSYGNKAVELGNIFSTLETINAPSFSFTAEPDFGKYFLPFFHAVFLIATTSLSSNIHRLDPTTTKYTLIMADPDAPNSQTPILAPFLHWIVSDVQPDCVPGQKRLTVAPYMFPTPLSLAPHLYTFLIYRQPRNYVPPAMLQNLPGLRARFPLQDYVKQNNLTGPIAGNFYQEGLENLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M3BP77</accession>
    <name>M3BP77_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Aspartate-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="4">1.2.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SEPMUDRAFT_152293</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the NADPH-dependent formation of L-aspartate 4-semialdehyde (L-ASA) by the reductive dephosphorylation of 4-phospho-L-aspartate. Mediates the second step in the biosynthesis of amino acids that derive from aspartate (the aspartate family of amino acids), including methioinine and threonine, the latter of which is a precursor to isoleucine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-aspartate 4-semialdehyde + phosphate + NADP(+) = 4-phospho-L-aspartate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.2.1.11"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:24286"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the aspartate-semialdehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.11" evidence="4"/>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF07963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756084.1">
        <property type="nucleotide sequence ID" value="XM_016907355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BP77"/>
    <dbReference type="STRING" id="692275.M3BP77"/>
    <dbReference type="GeneID" id="27904492"/>
    <dbReference type="eggNOG" id="KOG4777">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049966_1_0_1"/>
    <dbReference type="OMA" id="CEEEMKM"/>
    <dbReference type="OrthoDB" id="1894490at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009090">
        <property type="term" value="P:homoserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18130">
        <property type="entry name" value="ASADH_C_arch_fung_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02315">
        <property type="entry name" value="ScASADH_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000200">
        <property type="entry name" value="Aspartate-semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000016">
        <property type="entry name" value="Probable aspartate-semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051823">
        <property type="entry name" value="ASADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005676">
        <property type="entry name" value="Asp_semi-ald_DH_pep-lack"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00978">
        <property type="entry name" value="asd_EA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006416">
        <property type="entry name" value="PRK08664.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46718">
        <property type="entry name" value="ASPARTATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46718:SF1">
        <property type="entry name" value="ASPARTATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000148">
        <property type="entry name" value="ASA_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Semialdehyde dehydrogenase NAD-binding" evidence="15">
        <location>
            <begin position="30"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="14">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000148-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMF07963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="387" mass="41850" checksum="2CB8EBE9D9B16044" modified="2013-05-01" version="1">METAKHQIHEQGHDLVLRMAVNHSNFPPKRCGVLGATGSVGQRFILLLAQHPHFQLTAVGASPRSAGKAYKDAVKWKQATPMSKALGELVVKSCTPEEFKGEVDIVFSGLDSDVAEDTEMAFLKANIPTFSNAKNYRRNPLVPLVVPTVNLPHLDLIPHQRSHFQLEKGFLVCNSNCAVIGIVIPFAALQAKFGEINTVSVVTMQAVSGAGYPGVSSMDIIDNVVPFISGEEDKLETEARKILGGINTEKNAFTEQSALRISAACNRVPVLDGHMACVSLKFAKQPPPSAQEVKEALKAYVSDAQKLSCPSAPEKAIVLFDDDQPDRPQPRLDRELDRGYAVSVGRVREDESGIFDIKFVALSHNTVIGAAGSSILNAEAAVMRGYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M3BQQ1</accession>
    <name>M3BQQ1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_128781</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756549.1">
        <property type="nucleotide sequence ID" value="XM_016902232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BQQ1"/>
    <dbReference type="GeneID" id="27899369"/>
    <dbReference type="HOGENOM" id="CLU_2924187_0_0_1"/>
    <dbReference type="OrthoDB" id="2309723at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF08428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="61" mass="6827" checksum="64C3A624BF67CBD7" modified="2013-05-01" version="1">MLRQTTASPLLFGLSSRTETLQSLKIGIYYAVKAWSRLRLGIWAHADTAGGERYPEPVGYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>M3BTF8</accession>
    <name>M3BTF8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_16250</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF09935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758056.1">
        <property type="nucleotide sequence ID" value="XM_016908006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BTF8"/>
    <dbReference type="STRING" id="692275.M3BTF8"/>
    <dbReference type="GeneID" id="27905143"/>
    <dbReference type="eggNOG" id="ENOG502RKWE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016574_4_0_1"/>
    <dbReference type="OMA" id="HPITFWG"/>
    <dbReference type="OrthoDB" id="271595at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF30">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="24"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="82"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="157"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF09935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="657" mass="72815" checksum="16C1437C44CA3ECD" modified="2013-05-01" version="1" fragment="single">MFSILDAANGGFSSSRPRTAADRACDQCKSRKVRCAVQEPKSQKPCLTCAAKGVTCTYDKARKKRGPVGKRIEEIRLHQKGLATAGERQGPLHSPTASSGPRVSAAPAVRNAASEDHRERTPTWPLSPSPPSVVEASPGTHAEMDYTQQRSRQAAQHPEDRGSSEQPLRESSYEDLMANTSTFQVASLPNASPAPTGNPFVAIRELDLPPLTAAADIWPVKVNETTLLPWIDVYFTRLHPTIPILNRTSIYSNMLLRKHRTDPQYGAMLLGLCAFAMTQPVQTHEHASLTSRIEQGRLLLDECVKMRVSADFGENPTVEMVLTSFFLFACLFGSSQHKAARHRLREAVDLAHSLGLHLPDSYVGLSSEVKEQWLRTYLVLSVTERAYALQRYHPISFRGQPGITVRFMQAFDPLVTSEYISSLIYQDQSDSVGMTGLLYLMDTLDAINESVMDCWNGFCRYSDGNCEDFDRRKAMQMFRAQRRVREASISGNISFAPSVTPLPLAQLFESQQADISVTQFWTLNRLWTLCLSHQLLREQSDHCELRVDFACHVAHAALRYCETLELASMEIHGVGFISKMFDMAMGVIVAMNTSASIDLDSAISPIDGDAIPSTLDSTGSEFTVRALLKGLHNLICRDFRGGDHVYNARLAAALEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M3BU60</accession>
    <name>M3BU60_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="4">PPIase</shortName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_127864</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758336.1">
        <property type="nucleotide sequence ID" value="XM_016902176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BU60"/>
    <dbReference type="STRING" id="692275.M3BU60"/>
    <dbReference type="GeneID" id="27899313"/>
    <dbReference type="eggNOG" id="KOG0880">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_4_1_1"/>
    <dbReference type="OMA" id="ENHEITH"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000001">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0697">Rotamase</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5006532055" description="Peptidyl-prolyl cis-trans isomerase" evidence="4">
        <location>
            <begin position="29"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="39"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF10215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="208" mass="22757" checksum="E0C5A297E8D09359" modified="2013-05-01" version="1">MASLQRILVSFMVVLTFAFAYFAQTAEAQKGPKITHKVYFDIKQGDEELGRIVMGLYGKTTPKTAENFRALCTGEKGFGYQDSSFHRVIKDFMIQGGDFTKGDGTGGKSIYGAKFDDENFKLKHSKKGLLSMANSGKNTNGSQFFITTVITSWLDGRHVVFGEVLEGMDIVHKIENTPKGGNDKPTVAVTIAKSGELEVPAEGIRAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M3BZW3</accession>
    <name>M3BZW3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dpy-30 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_163274</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dpy-30 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761722.1">
        <property type="nucleotide sequence ID" value="XM_016908044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BZW3"/>
    <dbReference type="STRING" id="692275.M3BZW3"/>
    <dbReference type="GeneID" id="27905181"/>
    <dbReference type="eggNOG" id="ENOG502SE27">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115916_1_0_1"/>
    <dbReference type="OMA" id="PNGGATH"/>
    <dbReference type="OrthoDB" id="417678at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd22965">
        <property type="entry name" value="DD_DPY30_SDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007858">
        <property type="entry name" value="Dpy-30_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049629">
        <property type="entry name" value="DPY30_SDC1_DD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05186">
        <property type="entry name" value="Dpy-30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF13601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="143" mass="15322" checksum="4FD5D8627823C5D8" modified="2013-05-01" version="1">MADPDTNGTPVVNGDVDMKEELPAETTLNSIQQVADPTDPNPPPQSISDNPAPLGMSEHLSIIAPGVATPPTGATARPSSMPPQPLARPEKPVAHGGPTRQYLNTNVTPHLLEGMKYLAVYEPEKPLEWLANFLKERSKEVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M3C037</accession>
    <name>M3C037_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_155925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761807.1">
        <property type="nucleotide sequence ID" value="XM_016907650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C037"/>
    <dbReference type="GeneID" id="27904787"/>
    <dbReference type="HOGENOM" id="CLU_1099078_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032073" evidence="2">
        <location>
            <begin position="23"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF13686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="253" mass="27865" checksum="2A974E244C3F7335" modified="2013-05-01" version="1">MRKCPPLCLSLSLSLSLSLATGSPYPSRDMKQQKDHQAAAVPPSNRNWRTDTCKELLLYCTQPRRHSLKPCISQHYIPIMLLSRYVFSLAAFGLGLVTAELLDPALPCASDDFCLQPCKDSVYKDFENDITATCKQTSNGPFCDCTVSSDDNCKKVCVAVYAENYPEAVVKDGYQDNGRTGGCCCTADCSGVKDPEKRKECGGDEADEPQCWLQGRSEPCWLATERCMSKVSSTQDADVEHQYPVQSKSMVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M3C073</accession>
    <name>M3C073_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_64936</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761847.1">
        <property type="nucleotide sequence ID" value="XM_016909697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C073"/>
    <dbReference type="STRING" id="692275.M3C073"/>
    <dbReference type="GeneID" id="27906834"/>
    <dbReference type="eggNOG" id="ENOG502S50U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058846_1_0_1"/>
    <dbReference type="OMA" id="GKRITWV"/>
    <dbReference type="OrthoDB" id="8300214at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF13726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="330" mass="36128" checksum="AC1D24748D14BB3C" modified="2013-05-01" version="1">MSTQIDTATTVDDTTTTTTTATTIARLCLHDPTHFHTQYSQILHRLNLVQHWKAAAALSPGSNVLELGCGQGDCTVTLAYTVARGELGGRVVAIDPAELNYGSPYTLGQAQEHISRGPMGKRITWVRQEPLEYLSSSSSPLPGTAASESESKKNQPFFDATVLAHSLWYFATPSLVEETFRVIKQHPNTSKRLLLAEWALEATHKASQPHVLAALTQAALECRKPDDRKSLSNIRTVLGPKRLTELALAAGWQLERESRVPCGELLEDGKWEVAACLSPAFEREVREHVSDEREQAVVFALRDACEASLEAVPGGKEGVRAMDVWVASFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M3C0W2</accession>
    <name>M3C0W2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_133103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762042.1">
        <property type="nucleotide sequence ID" value="XM_016902543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C0W2"/>
    <dbReference type="GeneID" id="27899680"/>
    <dbReference type="HOGENOM" id="CLU_460169_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF13921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="593" mass="66685" checksum="ABA0BA14774C3AE7" modified="2013-05-01" version="1">MTPTVDTVLHGLYEPHEISPVHLSTRQDIVRYLEQERRNVVFVIRRTAARSRDDPLHKRLRYFLNIVSKTEIDFDLLEATAVLPTTLYTIFNYADPEGRFLPEEKYCAKLLYADYLSQGWQGRTKAFAWSKDEWYPFIKNKLAIPNAIKGRAKPDASKITRQRSDSGAAKRHARRKDSVKSVTFNDTTSVVEFDDNSPDVIQRASSLDTGRDRQAQSVEPLVPTEHMRRPGQRAPSPLLPPPSPRFVEVPLASPRFVDVPLASPRFLEVPEWKGSESTRRHRRDSAHAPHPHLPPSPRQDYPARGQSPNTERQPQDRAHSTTSDLPASPKLPSPPPDELREESSPRQVSIITPVATFPVEELKRKREVTLLENINRLRSQVESIDIQQLPRTPWLEHLRSTQHDPSSEQAPSTKETGTAEQPVVESELPLESPSTTTLADSTEPVEAVAKTDDAENSQELEHDGGSSEQDSSTETVDSIEQHSDTESAISTESDIITESDISTEQDISRERHDSMDHGAEPADQIKVEKAETTEEDAQPASQCDVKKIRRYATRGLPALGPVRMRICSIEQKARLQPQVCSPMHSPLWCSGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M3C1M9</accession>
    <name>M3C1M9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">adenine phosphoribosyltransferase</fullName>
            <ecNumber evidence="7">2.4.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SEPMUDRAFT_62388</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.7" evidence="7"/>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762337.1">
        <property type="nucleotide sequence ID" value="XM_016909600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C1M9"/>
    <dbReference type="STRING" id="692275.M3C1M9"/>
    <dbReference type="GeneID" id="27906737"/>
    <dbReference type="eggNOG" id="KOG1712">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063339_1_1_1"/>
    <dbReference type="OMA" id="QAYDLEY"/>
    <dbReference type="OrthoDB" id="363185at2759"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002055">
        <property type="term" value="F:adenine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003999">
        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006168">
        <property type="term" value="P:adenine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000004">
        <property type="entry name" value="Adenine phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00004">
        <property type="entry name" value="Aden_phosphoribosyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005764">
        <property type="entry name" value="Ade_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050054">
        <property type="entry name" value="UPRTase/APRTase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01090">
        <property type="entry name" value="apt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002634">
        <property type="entry name" value="PRK02304.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002636">
        <property type="entry name" value="PRK02304.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315:SF3">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="13">
        <location>
            <begin position="118"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMF14216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="264" mass="27585" checksum="2DAA0C20B81E4606" modified="2013-05-01" version="1">MSAGAPSQSIVNATKAAQHAPDNTVNNAADVAATSAHPPPNAPDPTAADSTTPKRVKTSHNGPEGGLAATAASGTSQLASLKVKLKSGLRQYPDFPSPGILFEDIMPLFSNHDLHQNLITALELQLVDTFGPHHGIDVVVGLESRGFLFGPTLAWKIGAGFVPVRKQGKLPGQCITEEYQKEYGSDSFQMQGDAIKKGAKVVIVDDIIATGGTAAAAGNLVQKLGGELVGYVFIMELDFLKGRDKLNAPVHTLLSGQDEALASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M3C1T2</accession>
    <name>M3C1T2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_131968</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762392.1">
        <property type="nucleotide sequence ID" value="XM_016902458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C1T2"/>
    <dbReference type="GeneID" id="27899595"/>
    <dbReference type="eggNOG" id="ENOG502SUWJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128883_0_0_1"/>
    <dbReference type="OMA" id="WGHNYAV"/>
    <dbReference type="OrthoDB" id="414540at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF14271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="189" mass="20918" checksum="0B2CE2DA3FF3B58E" modified="2013-05-01" version="1">MPATTTPLLPPSEAEDIIYSKLSTTARAFIEATNSATPRDNNPDYDLLRSFCAPHFRISWAPKLFARNSPVLGAPKDIDGFCNHIKDMSANLSVWAILVQDVLVDVKQRTVVVRADFWMLPGDGGDKVQNDIVFFLRCDESGEKIVDCCEYVDPFASQQIRERISAKAWKGNAVSEPVNGTNDVDGAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M3C402</accession>
    <name>M3C402_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cullin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SEPMUDRAFT_146975</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SO2202</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 12">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF14971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763092.1">
        <property type="nucleotide sequence ID" value="XM_016904002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C402"/>
    <dbReference type="STRING" id="692275.M3C402"/>
    <dbReference type="GeneID" id="27901139"/>
    <dbReference type="eggNOG" id="KOG2166">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004747_6_1_1"/>
    <dbReference type="OMA" id="IREWDRY"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000007">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000011">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000026">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.130:FF:000003">
        <property type="entry name" value="Cullin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000029">
        <property type="entry name" value="Cullin homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1030.10">
        <property type="entry name" value="Ring Box Chain A, domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01256">
        <property type="entry name" value="CULLIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cullin family profile" evidence="13">
        <location>
            <begin position="418"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMF14971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="779" mass="89686" checksum="DF78BF75EE1EF0CE" modified="2013-05-01" version="1">MSNSDLAIKASARVAPPIPTSKDDINGTWNFLEWGVDRIMFNLSEGVDLKTYMSLYTSIHNFCTAQKAAGMGSQQSNLNSNHRGAHLLGEDLYHRLNEHLKVHLAAVHAEMIKHTDEALLTYYIKEWKRYTQAGTYNHHLFRYLNRHWVKREMDEGKKDIYDIYTLHLVRWKEDMFGSTQNAVMDAVLRLVEKQRNGETIEQSKIKDVVNSFVSLGIDEADSTKTTLDVYRTYFEKPYLEATEKYYEVESHRFLAENSVVDYMKKAERRLDEEKERVPLFLLNEIMAPLMKCCENALIAKHATTLRDEFQILLDNDREDDMARMYKLLARIPEGLDPLRARFELHVRQAGHLAVEKVAGQGDSLDPKAYVDALLEVHTQYSALVQKAFTGESEFVRSLDNACREYVNRNKVCERNSSKSPELLAKHSDNVLKKSTKATEEDNMEKLLDQCMTIFKYVEDKDVFQKFYSRHLAKRLVNGTSASGDAETSMISKLKDASGFEYTNKLQRMFQDVQTSKDLNNAYEEWRSQTIDKEDRKEEVDATYQILGTGSWPLQPPTSPFAPPDVIIKTYERFQTFYSNKHGGRKLSWLWHLCKGEIRANYAKMNKVPYTFSVSTYQMAILLMFNDSNTVTYDDMAELTSLAKETLDPSIAIMIKAKVLTASPEGASPQSGTSYSLNYGFKNKKLKVNLNIAIKSEQKQEVEDTHKTIEEDRKMLMQSAIVRIMKSRKTMKHAQLVSETIGQIRSRFSPKVSDIKKCIDILIEKEYLERLEGDDLGYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M3C4F8</accession>
    <name>M3C4F8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Di-copper centre-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_147120</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763292.1">
        <property type="nucleotide sequence ID" value="XM_016904094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C4F8"/>
    <dbReference type="STRING" id="692275.M3C4F8"/>
    <dbReference type="GeneID" id="27901231"/>
    <dbReference type="eggNOG" id="ENOG502QRET">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035914_0_0_1"/>
    <dbReference type="OMA" id="FNFLAWH"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF125">
        <property type="entry name" value="N-ACETYL-6-HYDROXYTRYPTOPHAN OXIDASE IVOB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032529" evidence="3">
        <location>
            <begin position="19"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="4">
        <location>
            <begin position="314"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF15171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="392" mass="43817" checksum="EFFACE16B2116192" modified="2013-05-01" version="1">MRFATTVACVATAGLVAAQAPSISDYSAQQIASGEAWRNISTIADESMQSNIGSRSNAQCTYENAAVRQEWRTLSPETRKSFTDAVTCLQNHAPTRMTAAEAPTYPGVKSRYDEYVATHINYTLNIHDTADFFAWHRAFIHFMEQDLINLCGYTGVMPYWNWAEDAAAPQDSALFSGDAYSMGSNGRYIAGRSDTWLAQQDVTYSPGTGGGCVESGPFSEYTVNLGPLGLPNYDNVDTPFQYNPHCLERDINPWFSTRYNTYERLTSVVLDYIYIEDFQCQSQGMCGDNKFGVHGGGHWQTGGSMMDFYSSPADPLFYVHHAQVDKMWVIWQNLDIYRRQNIIKGTGTLGCSSPDCPEMTLNDRLPFGLVADDQTFSTLMDNFAGPFCYRYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M3C4N7</accession>
    <name>M3C4N7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NTF2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_19175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763387.1">
        <property type="nucleotide sequence ID" value="XM_016908312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C4N7"/>
    <dbReference type="GeneID" id="27905449"/>
    <dbReference type="eggNOG" id="ENOG502R9JQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2339331_0_0_1"/>
    <dbReference type="OrthoDB" id="5596743at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058645">
        <property type="entry name" value="NTF2-like_dom_7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26534">
        <property type="entry name" value="NTF2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTF2-like" evidence="1">
        <location>
            <begin position="2"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF15266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="98" mass="11110" checksum="D981F3A6B8DF033E" modified="2013-05-01" version="1" fragment="single">SCLTDSHAQRIADNFSHLFSDFSEEFANSTLTEDITDQTDSVGWLISNGTDCPHPLGSVTLSSRREFLDAQATQPNLPFIIENVWHDCTNVFTRWKFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M3C7L0</accession>
    <name>M3C7L0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_121756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456289">
        <property type="protein sequence ID" value="EMF07890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756011.1">
        <property type="nucleotide sequence ID" value="XM_016901720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C7L0"/>
    <dbReference type="GeneID" id="27898857"/>
    <dbReference type="HOGENOM" id="CLU_1620107_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF07890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="164" mass="17686" checksum="3B890D7D2DC97A45" modified="2013-05-01" version="1">MDTVYESKEYKAYQAAVASKNWEIFPAFEPDAAGECVVHHGENVCRLQRGEGICGKTYNGISKTTNLRSHIKDHEGYRAKPAKKGTVSQAEVDNTRNFFAHFLQAPPPAPLPAPTSTPKSKKKDKASSASASGSRPQGVNKKSTPSKPSKKSGISARELSGLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M3C878</accession>
    <name>M3C878_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HAD-superfamily hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_18973</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF08100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756221.1">
        <property type="nucleotide sequence ID" value="XM_016908310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C878"/>
    <dbReference type="STRING" id="692275.M3C878"/>
    <dbReference type="GeneID" id="27905447"/>
    <dbReference type="eggNOG" id="KOG1618">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030880_1_0_1"/>
    <dbReference type="OMA" id="HDKRMLV"/>
    <dbReference type="OrthoDB" id="270009at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006353">
        <property type="entry name" value="HAD-SF_hydro_IIA_CECR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01456">
        <property type="entry name" value="CECR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF57">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF08100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="360" mass="40233" checksum="49317C472C301E12" modified="2013-05-01" version="1" fragment="single">PKFAFAFDIDGVLLRSSAPLPGASQALSYLHQEQIPYILLTNGGGKTELARITDLNRKLGIDFLHETDIVQSHTPFTQLWGLKSNGMTVLVCGGDRDGAKEVAKSYGFENVVTPGDLVVGYPELWPFNAPLKEYYESFAEKLPKPLYSPTGNPVLDAKKTLKIDAVFVYNDPRDWGLDASIILDLLLSEKGFLGTLSEKNGREDLSNCGFLLDGQPHVFFSNPDLWWATSYHLSRLGQGGFQAALKGLWERVTEGKASLERQVTVIGKPTQLTYEFAEQSLREREHVDVKRVYMIGDNLESDIAGANGYESPWGSEWKSVLVKTGVWRDGMEWKENQKPYAIKENVLEAVKWAVEDAKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M3C8D0</accession>
    <name>M3C8D0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SCO1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_136945</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SCO1/2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF08150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756271.1">
        <property type="nucleotide sequence ID" value="XM_016902815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C8D0"/>
    <dbReference type="STRING" id="692275.M3C8D0"/>
    <dbReference type="GeneID" id="27899952"/>
    <dbReference type="eggNOG" id="KOG2792">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050131_0_2_1"/>
    <dbReference type="OMA" id="MLYFRVE"/>
    <dbReference type="OrthoDB" id="2125396at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02968">
        <property type="entry name" value="SCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000013">
        <property type="entry name" value="Blast:Protein SCO1 homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003782">
        <property type="entry name" value="SCO1/SenC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151:SF5">
        <property type="entry name" value="AT19154P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151">
        <property type="entry name" value="ELECTRON TRANSPORT PROTIN SCO1/SENC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02630">
        <property type="entry name" value="SCO1-SenC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="157"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="4">
        <location>
            <begin position="195"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR603782-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR603782-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF08150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="331" mass="37316" checksum="44C821781A2EA854" modified="2013-05-01" version="1">MDGWEVDCKVKSGDVGAERTSDDIPSHHLVIDKNICPSLSFTQISIISRLTMASPLFNTLRTAPSGLCKQCITTSRTTLTKTTRHSIKQQAFRPFSSTPIVSRQRTIQEAKSRYRLGPFSWQSGLLFLAAGTGLTFYFRYEKARMSRQRIAEANKGMGKPLVGGPFHLVDHHGKEFTEADLVGKYSLVYFGFTHCPDICPEELDKMAGMIEKVKEKHGEGKMRSVFISCDPARDTPEVLRRYLREFHPDILGLVGTWEEVKSVCKAYRVYFSTPPDVKPGQDYLVDHSIYFYLMDPEGDFVEAIGRNFTVDAAAKVINDHIADWKGKIDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M3CAZ2</accession>
    <name>M3CAZ2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_159072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757116.1">
        <property type="nucleotide sequence ID" value="XM_016907823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CAZ2"/>
    <dbReference type="GeneID" id="27904960"/>
    <dbReference type="eggNOG" id="ENOG502T1ZY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1361169_0_0_1"/>
    <dbReference type="OMA" id="CFKHLTR"/>
    <dbReference type="OrthoDB" id="4771937at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF08995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="201" mass="22003" checksum="51B7DABF69CF973E" modified="2013-05-01" version="1">MGLLRSPSQILRKRRAEGNQPAPAAEAGAGAGAEPKAEPEAEPKAAEGEEVVAPVVSNPIPYAPSTTELLLRSDREKSATAYRRAQKAEAEYRAKKDAERSRNDYKSSKSHIKTSCHELKLGLKTAFSSVKTSPAVLKEKQVNAGTRSAVKKQEKEDEKRRKLDAKLKKVKEQQAKLEEANKENNDENTPVADVVEESALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M3CDF8</accession>
    <name>M3CDF8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribonuclease H2 subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ribonuclease HI subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_68345</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759202.1">
        <property type="nucleotide sequence ID" value="XM_016909817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CDF8"/>
    <dbReference type="STRING" id="692275.M3CDF8"/>
    <dbReference type="GeneID" id="27906954"/>
    <dbReference type="eggNOG" id="ENOG502SCDS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057573_0_0_1"/>
    <dbReference type="OMA" id="YYFCPKL"/>
    <dbReference type="OrthoDB" id="29098at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09270">
        <property type="entry name" value="RNase_H2-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040456">
        <property type="entry name" value="RNase_H2_suB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019024">
        <property type="entry name" value="RNase_H2_suB_wHTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041195">
        <property type="entry name" value="Rnh202_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13383">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13383:SF11">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09468">
        <property type="entry name" value="RNase_H2-Ydr279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17745">
        <property type="entry name" value="Ydr279_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rnh202 triple barrel" evidence="8">
        <location>
            <begin position="43"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Ribonuclease H2 subunit B wHTH" evidence="7">
        <location>
            <begin position="129"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="248"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="366"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="268"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="377"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF11081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="430" mass="47168" checksum="47F59CE343C3FF9F" modified="2013-05-01" version="1">MARTRASKPAANAKNDGAAPTSTKPTLKKKLDAPVNTPPQLFILPKHASTAARIASIPNPSTLSPSRYFICPDQGFHEFTKIAAPKAQKRSWLLAPDRSAQVEEAQKNDDGYVLQTPDMLVATPIDPLFLLLPALMGEETGAQEFMASSDYTAKLGESAPQLRSLLESDSTKTLERIFESRVEAVSDCMDMGDEKMYALSLPKLVKELVSKARRMSARGLPATMEEHFVRQALDVPVLSVKREESGFSMASEDSVEGAESQPPSGADSQESTTTTTSVEPTATSISITSTNDTCKEIADLLRLRVALNFVLTSYILPKLKKRLDPLLLDPKVIDIDFAPLDKQLAHIAQLKKDAQALRSLSDNISRKRAHEVDEEAGERAAEKKRKLEEEEKKKKNISQGVKRLAKADTSGMKKMSSFFTKMPPAKTAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>M3CF57</accession>
    <name>M3CF57_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SEPMUDRAFT_149100</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Transcription factor that is part of a SLN1-YPD1-SKN7 two-component regulatory system, which controls gene expression in response to changes in the osmolarity of the extracellular environment. Under low osmotic conditions, phosphorylated and activated by the phosphorelay intermediate protein YPD1. Also activated in response to oxidative stress, independent on the two-component regulatory system. Regulates heat shock genes in response to oxidative stress and genes involved in cell wall integrity in response to osmotic changes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the SKN7 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EMF12413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016905340.1"/>
    </dbReference>
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    <dbReference type="STRING" id="692275.M3CF57"/>
    <dbReference type="GeneID" id="27902477"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Stress response regulator/HFS transcription factor"/>
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    </dbReference>
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        <property type="entry name" value="Transcription factor SKN7"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
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        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
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        <property type="entry name" value="Sig_transdc_resp-reg_Skn7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002595">
        <property type="entry name" value="RR_SKN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 13" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="16">
        <location>
            <begin position="377"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="208"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="278"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="495"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="595"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="521"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="13">
        <location>
            <position position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00057149"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00061465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR002595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMF12413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="631" mass="69553" checksum="8E9A845B10751C7D" modified="2013-05-01" version="1">MDSQSGQGANNSSDFVRKLYKMLECPQDESVVRWGNEGDSFVVLENEKFTKHILPKHFKHSNFASFVRQLNKYDFHKVRHNNEEGGTSPYGPGAWEFKHPDFKMNNKDALDNIRRKAPAPRKANTGTEADMMPTQQVDMINTQLVATQQQLQSLQERYNELNIHHTIMMQELIGVQKTVINHEHVMQYVMNFLNSVDAQRRRESRIVNPNPFANGTGVNGANAPGSAAAVPPPPEEDVPASPLQHASKLLEQVNADHMLNTRNLEQMNEAQIRMNAALTTPPPDHLARNGVTRSSSRGAQPNSAGSSSSHGYDLDNMVYPIGQNPQGIDPMYSEHVNNIPYSLPAKGADGNFHQPPQPTDVRKKSTQVDPGWVRQPQILLVEDDQTCRRIGGKFLFAFQCHIDSALDGLEAVNKLNSGAKYDLVLMDIIMPNLDGVSATHLVRQFDTATPIIAMTSNIRSDDISMYFQHGMNDVLPKPFTKEGLLAMLEKHLSHLKKGQQGIEPMPPPLKANNRSLKSEDSPATSPATASNWNSPNQLTGGSPSNSNLGDEGPYVVSAPYAQPVLHAPSTQMYAPPASGMIPPHVAQRRAIDSITGGPEMAGDAKRQHMYTSGPMGTLAVPPPQMLQRPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M3CJL5</accession>
    <name>M3CJL5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mediator of RNA polymerase II transcription subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mediator complex subunit 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_147861</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the Mediator complex subunit 1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EMF13998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016904559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CJL5"/>
    <dbReference type="STRING" id="692275.M3CJL5"/>
    <dbReference type="GeneID" id="27901696"/>
    <dbReference type="eggNOG" id="ENOG502RYK5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008378_1_0_1"/>
    <dbReference type="OrthoDB" id="5310959at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019680">
        <property type="entry name" value="Mediator_Med1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35041">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35041:SF4">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10744">
        <property type="entry name" value="Med1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0010">Activator</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med1" evidence="9">
        <location>
            <begin position="1"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="310"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF13998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="439" mass="48075" checksum="1FA2924688D8EE9E" modified="2013-05-01" version="1">MDRLCKEQVDCFEAMKGLHTSLEKLYELEKAAVKTLRELKGSSADAIAEREVLRKRSGRPSLHGNGKIGLTLDYWTSNFDPSVSKDDSAMDVDGPEDADTQADDSPDVWSLRVEAQSCAAGIYPPLRVSDAWLPETFELPSPESADGIPWQDPPNTTVSASSSGTGGDAMAIDGGERLPDLRFVAKLDPPVLLPLGIAAPVLASLGDQYSQSTMFPLYHLKLLGFHSGDMAFRVISESSVPVSGAPKDREEDALHEYVLEVSKADLGYTLEEVPFSHPRQLVELLPTLRQWARISILLKETFDTPRLSIDPSSELSSNEPPTADLESMDLLPPTSGEVAKTRVDIAFSSNTFKEVAIPSVHMSFPIPCKDLVYQVAFQVVPNAEIVVLDCDHPVVVKHGPGEDAEADSEAQEKRELARALEICEDLGVWIEWIKKKARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M3CLR5</accession>
    <name>M3CLR5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acid protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_115996</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762854.1">
        <property type="nucleotide sequence ID" value="XM_016901212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CLR5"/>
    <dbReference type="STRING" id="692275.M3CLR5"/>
    <dbReference type="MEROPS" id="A01.080"/>
    <dbReference type="GeneID" id="27898349"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013253_0_2_1"/>
    <dbReference type="OMA" id="VGQKRIG"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06097">
        <property type="entry name" value="Aspergillopepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034163">
        <property type="entry name" value="Aspergillopepsin-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF1">
        <property type="entry name" value="ASPARTYL PROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="5">
        <location>
            <begin position="172"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF14733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="468" mass="49751" checksum="C7EC989914731FED" modified="2013-05-01" version="1">MTIEDIKTVYQQKHNLPSTYQNFAHGNPYNHGTVPTATTKGAVLGTSIKMAVPTDPVKTADAAQATPLQGLHKVSVVRNPKFKAKGTGDFAGVCRKFEITPTLPTPFTIIHTIVDGTGQALANVGQAITNAFSPDSSQASHPRVVTRMVNKPDSSGKVGHLDATNVQNDSEYLAPVGIGTPQQKLHLNFDTGSSDLWVWSTLLPPDQIQYGDGSTAGGSVGTDSVTVGGLCVEGQSVELAKNLAQSFEQSAGDGLLGLAFGSINTVKPQPVHTPVENMIAQADIPSNSELFTCYLTSSKDSEPDYYTFGYIDQDLVKGRPIYYAAVDSSRGFWSVASTSVVIDGNKIPLAGNTAIMDTGTTLSLIDDATCKNVYAAIPGSRYDNDQGGFIFPSNTKPPVISFAIGDQHFTVRKSDLAFADIGGGMMYGGIQSRGNMTFSIFGGTHLKGMYAIFDQGKKQFGFVQKPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M3CM49</accession>
    <name>M3CM49_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_113994</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF14858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762979.1">
        <property type="nucleotide sequence ID" value="XM_016901066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CM49"/>
    <dbReference type="STRING" id="692275.M3CM49"/>
    <dbReference type="GeneID" id="27898203"/>
    <dbReference type="eggNOG" id="KOG0351">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1161762_0_0_1"/>
    <dbReference type="OMA" id="DECHHIY"/>
    <dbReference type="OrthoDB" id="2608216at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF154">
        <property type="entry name" value="RECQ HELICASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14720)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="55"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF14858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="239" mass="26602" checksum="317DF48383D52FFC" modified="2013-05-01" version="1">MPSNEPQVEPDLAVRLKRTRVHKDDDSATLLAAARRLTGIADFKWRSVQQLAALRTILGGAEEIVVVMPTGAGKSLLFMLPASLYTAGTTVVILPLISLRADIVYRLRSLKLDHSVWAPRSRQRAPVVLVSIEAASTRDFIEYAQGLVADGQLDRVVIDEAHLTIAALEYRPVMNAASELRRLRTQFLYLTGMLPPSIEADFRRHNCLAIPTILRIDCNCPQVVYTIERCPEPADELYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M3CML8</accession>
    <name>M3CML8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="4">2.7.7.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Mitochondrial DNA polymerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SEPMUDRAFT_147034</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Involved in the replication of mitochondrial DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 19">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA polymerase type-A family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="4"/>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15053.1"/>
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        <property type="nucleotide sequence ID" value="XM_016904045.1"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001524_2_1_1"/>
    <dbReference type="OMA" id="AMHITNL"/>
    <dbReference type="OrthoDB" id="5588663at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005760">
        <property type="term" value="C:gamma DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006264">
        <property type="term" value="P:mitochondrial DNA replication"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="DNA_pol_gammaA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA polymerase gamma, mitochondrial"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DNA polymerase gamma, mitochondrial"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA-dir_DNA_pol_A_CS"/>
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        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
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        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
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        <property type="entry name" value="DNApol_Exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047580">
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    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DNA POLYMERASE SUBUNIT GAMMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF18136">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00867">
        <property type="entry name" value="DNAPOLG"/>
    </dbReference>
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        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00447">
        <property type="entry name" value="DNA_POLYMERASE_A"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family A palm" evidence="16">
        <location>
            <begin position="689"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="474"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1060"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1137"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="1088"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1143"/>
            <end position="1158"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
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        </source>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00057053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMF15053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1180" mass="131960" checksum="B66CC359F8F9B3D7" modified="2013-05-01" version="1">MRSRCQRHLVNALERTQQTSLLRRIPLTRPCAHRSYAAASATSSHPRSLAVPSSARYNEIGVQQVSAHVHPQLFPQTTAAKPDDALVALSKDHLARHDLLGKTSDNSEPIGFDLPDLQGASLDEHFYKLGMDSAEPYLSLATKYARASPPPRPRRWEQRAGWTKYHEDGTSEAVEYPDEEVLTFDTEVMWHETSFPAMACAVSERHWYAWLSPWLLGESTNDRHLIPLGPRKKARIVVGHNIGYDRARIAEEYHLEQSQTFFIDTMSLHVATNGMCSRQRPTWNKHKKARDLQDKIAASDDSADLAALLESGKATFDSEEELWVGRASVNSLRDVAKFHCNITIDKARREWFGELDREGIVERLDELLDYCAADVDITHKVYKKVLPLFLETSPHPVSFAALRHLSTEILPVNRSWQSYIANAEATYHRLSSGVQERLIDLTERAVEHRGEPKVIRHDPWLSQLDWGGQEVRMVKGKKKGDPPRPAARQKKPGMPNWYKDLFSTNDADIALTVRTRIAPLLLRMAWDGHPLIWSDKYGFTFKVPHSEAQKYREQGMTTCDMMEEANLMLHDDLDHTYFKLPHKDGPDARCTSPLAKGYLQYFENGTLSSEYAYAKEALEMNASCSYWISARDRIMSQMVVYDSERADAPAQDTDLGYILPQVIPMGTITRRAVENTWLTAANAKKNRVGSELKSIVTAPPGYAFVGADVDSQELWIASLVGDSSFKIHGGNAIGFMTLEGTKAAGTDLHSRTAKILGISRNDAKVFNYGRIYGAGLKFAQSLLRQFNPSVTEEQAKMTATNLYHETKGSKSGSKAIRERKFWRGGTESLVFNKLEDFAEQERPRTPVLGAGITEALMRRFISKGGFMTSRINWAIQSSGVDYLHLLIVSMEYLCKRYNIDARLALTVHDEIRYLSKAEDKYRTAMALQVANVWTRAMFSQQMGIDDLPQSCAYFSAVDIDHVLRKEVDMDCITPSHPNKIAPGESLDIVQLLAKGTQAFLDPDVVPTRTPQPGQFQYTPRRPVMEGLQPPNAQAYLQAQIASSPAELNKIIRDLSKPAVVTSKSRRKDNVDGNFTLTGTTPLPAKGKAAPKPRVRKPRLPATKAHSSSLIATARNYSSLLPPESRWHMSSSDWANIGTPMDLSSSSSSSSSSPGSRSSLNGSAVMPLRHSGVSSYVRSAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>M3CN57</accession>
    <name>M3CN57_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_147158</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763349.1">
        <property type="nucleotide sequence ID" value="XM_016904122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CN57"/>
    <dbReference type="GeneID" id="27901259"/>
    <dbReference type="HOGENOM" id="CLU_1887056_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF15228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="135" mass="14694" checksum="C80C36F9F305854C" modified="2013-05-01" version="1">MLTIVQSQSYVGGRTAKLDHETLAISWLGDHGACPQIAFATTTTRPVRGHGGSHAALSALMLATPLVHGHDAEMGHCIRISEDQERLVNARFRRLPTKLTFIWSASGTSSGIVVNLSLKPSEAMVRSDHLERPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M3CR82</accession>
    <name>M3CR82_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Amidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_106325</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF16173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764294.1">
        <property type="nucleotide sequence ID" value="XM_016900627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CR82"/>
    <dbReference type="STRING" id="692275.M3CR82"/>
    <dbReference type="GeneID" id="27897764"/>
    <dbReference type="eggNOG" id="KOG1211">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_14_2_1"/>
    <dbReference type="OMA" id="QWPAISV"/>
    <dbReference type="OrthoDB" id="566138at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678:SF34">
        <property type="entry name" value="OS04G0183300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="3">
        <location>
            <begin position="29"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF16173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="484" mass="51733" checksum="82A2A352348D519A" modified="2013-05-01" version="1">MAGSLPPQYRSLTELQEAYHGGTTTVAAVTEQYLAAIESLQSLNAITAVNPKAVEEAAKLDELPQHQRGPLYGLPIVIKDQIETAGIATAYGSKACKDYIPTQDATLVRKLREAGAVILAKTAMPDWAAAWFSTSSLTGTTQHPMDPSRDPGGSSSGSGTAVAAGMALAAIGGDTGGSIRLPSSFCGLVGVRVTPGRISRDGMSSLVLTQDTPGPMAKCVEDAARILDVVVGYDERDEYTSINALASKQTPTTFVDAVREPVIAGKRLGVLRQVFGGHQGINSVLDRTLGELKSSGAELIDVEIPGLKDFIQKTSVYILRSRTDINNFLSSREGLKHLNIEDLVEKGEYHHSLDLLGGISKGPTDMMQSPHFSKAMTAIQQFQRTVASLFAKFDLDAMIYPTCQALAPKTKDVVEMRHLSLDYPTNTVIGSQLLWTAISVPVGMAKDVEYPDDPELPVGLEILGIPLSEERILNLAAGIEAMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M3CW89</accession>
    <name>M3CW89_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_121731</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456274">
        <property type="protein sequence ID" value="EMF07921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756042.1">
        <property type="nucleotide sequence ID" value="XM_016901711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CW89"/>
    <dbReference type="GeneID" id="27898848"/>
    <dbReference type="HOGENOM" id="CLU_1994040_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF07921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="150" mass="17578" checksum="B3BDE3913B65DC17" modified="2013-05-01" version="1">MPKRKSNAPEALANKRAKLGAASKSLEEYSLKLNTLRDRERTAAIDEEKRAQDRYRKARNESFARFKKVQIKEYTSFESLAKDEQQELIEGWRKIHTKEYNQKATKKQTGKSITLPPDEQAKIDKADWFLELGDIDSKERLTFQKEDQIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M3CYY0</accession>
    <name>M3CYY0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_120761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756987.1">
        <property type="nucleotide sequence ID" value="XM_016901634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CYY0"/>
    <dbReference type="GeneID" id="27898771"/>
    <dbReference type="HOGENOM" id="CLU_710116_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF08866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="389" mass="43345" checksum="CFC74A61610EC74B" modified="2013-05-01" version="1">MSTTGHAGASPPSRGCPVQTPMNHIQARPTPRSSNLSEPSNASRKRQTPGNTKMPEFCDLTGDTRTWELISEDHSRELIGLPPRGKSYIDLIEVDKVDPDSVLHDSSVEVSASTTERAHEAPPLRRSPHPPALPSTCVQTPETDNRSGLFKDIDWTPSLTRPKAHPPQDGLYSPRRRSNSRRRPDLEPQERLAKRPRKSASAGWPDSDRELHVFDSMALLQWNRTTHVGLQTTPSLHEDKDMSSPRESENIANRHPPNQLHRLSFSSRYNSREELPTPISLDHGPPHLPNLGINDTTASPLNRESGISGYPGPTSLERRHITRAALHSSRAHPSSTHHNRPRNGRRQTRIMKSTPRPKPHMSNSRTPPPGADVKPSELESVDDPVESIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M3CZ16</accession>
    <name>M3CZ16_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BEM46 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_151002</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF09899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758020.1">
        <property type="nucleotide sequence ID" value="XM_016906535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CZ16"/>
    <dbReference type="STRING" id="692275.M3CZ16"/>
    <dbReference type="GeneID" id="27903672"/>
    <dbReference type="eggNOG" id="KOG4391">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029375_2_0_1"/>
    <dbReference type="OMA" id="QYWTSED"/>
    <dbReference type="OrthoDB" id="10249433at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF81">
        <property type="entry name" value="PROTEIN ABHD13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="2">
        <location>
            <begin position="88"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF09899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="294" mass="32820" checksum="EE438286201C7272" modified="2013-05-01" version="1">MASLLPWLRLPFYLSAAAVSLGGGALYYFQNEIIYPRNLPPGTRTEVPRPPQFDIEDYEELEIPTPDGETLSAFLIRPANRTQARPITILSFHGNAGNIGHRLPIAKVLSHDLGCTTVMLEYRGYGLSTGDPNEKGLAIDAQTGLDYIRNREDLKAHKIIVYGQSLGGAVSIDLVSKNKGAGDIKGLMLENTFLSIAKMIPKAVPIARYLAPLCHEYWRSEDLIPQITDVPILFLSGMRDEIVPPSHMKELFKLAKTPQVMWKELPYGDHNSTVAEPGYFQYIEEFLQRYVTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M3CZ36</accession>
    <name>M3CZ36_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_119662</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF09924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758045.1">
        <property type="nucleotide sequence ID" value="XM_016901533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CZ36"/>
    <dbReference type="STRING" id="692275.M3CZ36"/>
    <dbReference type="GeneID" id="27898670"/>
    <dbReference type="eggNOG" id="KOG0800">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_866448_0_0_1"/>
    <dbReference type="OMA" id="RNDSAFM"/>
    <dbReference type="OrthoDB" id="3625779at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969:SF69">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969">
        <property type="entry name" value="RING ZINC FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="31"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF09924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="321" mass="36042" checksum="753F561C655028B9" modified="2013-05-01" version="1">MNTIITTTSTRTAYLNHGLGPLTSIPEEAECAICVDECTEPVELRGCKHTFCRSCIVQWLSLRTKNTCPKCRAALFAFDDADRGPVGVDRIAVMSQTLANSGLLTGEFQVFSDDIGWTSSGIEQATASAHAWLGEQHHPNFAGMALIHRDRLGQHVVAMGNLILGYAQAMRRSYSRNQRRDWRIIIDFLYSIVEARNGAEMEATVMPQQLREQIRISLLQEDLYVDRFFEDDAESESLSGDMDVLLQYISHQAAEEFQRREVRARTIREEPSVLGKVYGGLELGLFYGSSSSSSRLSSIILILILIVTRQRGNERTFSLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M3CZH1</accession>
    <name>M3CZH1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-carboxy-cis,cis-mucoante lactonizing enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_151093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cycloisomerase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758150.1">
        <property type="nucleotide sequence ID" value="XM_016906592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CZH1"/>
    <dbReference type="STRING" id="692275.M3CZH1"/>
    <dbReference type="GeneID" id="27903729"/>
    <dbReference type="eggNOG" id="ENOG502SIAZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045869_0_0_1"/>
    <dbReference type="OMA" id="VQNYEYQ"/>
    <dbReference type="OrthoDB" id="1715191at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000244">
        <property type="entry name" value="Carboxy-cis,cis-muconate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050282">
        <property type="entry name" value="Cycloisomerase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344:SF4">
        <property type="entry name" value="CYCLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75011">
        <property type="entry name" value="3-carboxy-cis,cis-mucoante lactonizing enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF10029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="386" mass="43377" checksum="7CC17148CEA158DA" modified="2013-05-01" version="1">MLRYTTRRTVASLTLRQFSTKSTARMKHHLMIGTWTPPGAIFTVAFDDESLSLELVKRTEIPEDQPISWMTFDHARKNIYGAGMKKWGSYAVTSPSEISHSKSLSMGGHPRANDTDTKTRAIFVLAAQQPPYAVYGNPFYDHAGFLNVHSVDSNGALSENIQDAPLDERSAIHGMVFNSTETYLYSADMWSNKIWTHKKLADGTLELVGSVIAPAANDHPRWVEISKNDAYLYVLMEAGNRLCIYVIDPETHLPTWTRTSYPLIPPGMDASFPKMYRSDVVFTSQSGEYLFATSRSNSPKLTGYIAAFKLGKEGQIERQICLNPTPTSGGHSNAVSPCPWTDEWLALCDDEQGWVEIYRWKDEFLGRVAHLDIKEPGFGMNAIWYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M3CZN6</accession>
    <name>M3CZN6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_119827</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758225.1">
        <property type="nucleotide sequence ID" value="XM_016901547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CZN6"/>
    <dbReference type="GeneID" id="27898684"/>
    <dbReference type="HOGENOM" id="CLU_1397135_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032961" evidence="2">
        <location>
            <begin position="20"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF10104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="195" mass="20364" checksum="DA97D5EBE20177E3" modified="2013-05-01" version="1">MPTSNILISALLAGQYAAAAYIPLNNISNQPNVVIQSITLTQTVYAPASTISTTRPRKTVTSTSTHIVYETPTVVGINPINGLPAPTARPSPSQSSTETKPSVSKSSTARMCGSGQGRFFECANPTARPSMYQTKSFSSATTLATTTRKVSLSTSQKSNVGIVITPVTTATRQVSSSKSRSNVGIVITPVTIANV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M3D044</accession>
    <name>M3D044_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Coenzyme Q-binding protein COQ10 START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_151245</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with coenzyme Q.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the COQ10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758375.1">
        <property type="nucleotide sequence ID" value="XM_016906693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D044"/>
    <dbReference type="STRING" id="692275.M3D044"/>
    <dbReference type="GeneID" id="27903830"/>
    <dbReference type="eggNOG" id="KOG3177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079653_1_1_1"/>
    <dbReference type="OMA" id="QLHAAMM"/>
    <dbReference type="OrthoDB" id="292693at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07813">
        <property type="entry name" value="COQ10p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044996">
        <property type="entry name" value="COQ10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901:SF10">
        <property type="entry name" value="COENZYME Q-BINDING PROTEIN COQ10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901">
        <property type="entry name" value="SPERM PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Coenzyme Q-binding protein COQ10 START" evidence="5">
        <location>
            <begin position="70"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="31"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF10254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="278" mass="30644" checksum="0CF02E9F4B2B5853" modified="2013-05-01" version="1">MNSIRPLSSTLLQSCTKTPYTCRAASLANASIRPPTNRERPQRRGFFGAPGGSANPFGSNQTLTAQRTLPFPSTVVYDIISDVASYSQFLPYCRDSTVTKYSEPAQDGKKYPEEAKLVIGFNEHISEEFTSRVYCVPGKVVEAVSGNMKSSLSGEEIAHHSARPAPDQDPSRKDTVMAHLLARWSLKPYHYKPPPTSAIHKDDAHKNTAETNPVRSQDKTEVNLAIEFQFSNPMYAAVAGGVAPKIAEKMIEAFEKRVKEVMIGMGHVRDEAAKKRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M3D092</accession>
    <name>M3D092_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">phosphoribosylglycinamide formyltransferase 1</fullName>
            <ecNumber evidence="2">2.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">5'-phosphoribosylglycinamide transformylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">GAR transformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_71597</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(1)-(5-phospho-beta-D-ribosyl)glycinamide + (6R)-10-formyltetrahydrofolate = N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + (6S)-5,6,7,8-tetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15053"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="2.1.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GART family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758420.1">
        <property type="nucleotide sequence ID" value="XM_016909947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D092"/>
    <dbReference type="STRING" id="692275.M3D092"/>
    <dbReference type="GeneID" id="27907084"/>
    <dbReference type="eggNOG" id="KOG3076">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038395_0_1_1"/>
    <dbReference type="OMA" id="HYVDEGM"/>
    <dbReference type="OrthoDB" id="5575075at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004644">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046084">
        <property type="term" value="P:adenine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.170">
        <property type="entry name" value="Formyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01930">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004607">
        <property type="entry name" value="GART"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001555">
        <property type="entry name" value="GART_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00639">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43369">
        <property type="entry name" value="PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43369:SF2">
        <property type="entry name" value="PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00373">
        <property type="entry name" value="GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl transferase N-terminal" evidence="9">
        <location>
            <begin position="14"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF10299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="228" mass="24768" checksum="4B1A071DE7C3FA2A" modified="2013-05-01" version="1">MTSSSSPSDVAPVRITVLISGSGTNLQALIDASNTPALPNVQLVRVISDRKAAYGLTRAQNAHIPTTYHAWLPYKKQYPADDPSAPVQNSPARNAYDADLVPLILHDQPSIVVCAGFMRILTPSFLNPLAEKGVKIINLHPSLHKDLIGAGCIERAWEEFEQGKRTKTGIMIHYVIAEVDLGEPIVQQEVDIQGCGTLGDLQERIHQAEHGLIVEGTRRVVELSRGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M3D0V9</accession>
    <name>M3D0V9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cloroperoxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_24294</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759249.1">
        <property type="nucleotide sequence ID" value="XM_016908382.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D0V9"/>
    <dbReference type="GeneID" id="27905519"/>
    <dbReference type="eggNOG" id="ENOG502S6CG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029871_3_2_1"/>
    <dbReference type="OMA" id="FTAFNEN"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF1">
        <property type="entry name" value="HEME HALOPEROXIDASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="8">
        <location>
            <begin position="17"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF11128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="363" mass="38612" checksum="83DB98672B1E1ED7" modified="2013-05-01" version="1" fragment="single">STTTPFSATAQKISVSGIHAWRAPGPGDARGPCPGLNALANHGYLPRNGYATVLDLVTATTTVFGMGPMLATVLSVYGAAIDGSALAWSIGYNGPVIRGIGNSHGNYETDNSPMRGDLYQYGSNSDLVISQFEKFYSLQPNDNTANYNIDVLAQFRAIRFAESIEKNPYFYYGPFSGTTVSIAAYSFIYRFMANHTAEAPDGVLNGEVLKSFMAISGNPGSFTWTRGHERIPENWYRRSLTDGYELDGIQADGDVFQSTTPQSTGPGCNTGTVNSYVEIDSSYQDYDFSSPTAGVCFAVNTILGETSLGSVVTGLVEQLILPIQNSLGCATVPARNDSVANVCPGYAFYGGPTADIAPGAIQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M3D1L8</accession>
    <name>M3D1L8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_118336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">SO2202</strain>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Henrissat B."/>
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                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
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                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">SO2202</strain>
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    </dbReference>
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    </evidence>
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    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>M3D5E3</accession>
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    </protein>
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        <name evidence="13" type="ORF">SEPMUDRAFT_64255</name>
    </gene>
    <organism evidence="13 14">
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        <lineage>
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            <taxon>Ascomycota</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
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    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
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    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
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        <property type="entry name" value="ABC_TRANSPORTER_2"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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    <feature type="transmembrane region" description="Helical" evidence="10">
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    <feature type="transmembrane region" description="Helical" evidence="10">
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    <feature type="transmembrane region" description="Helical" evidence="10">
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    <feature type="transmembrane region" description="Helical" evidence="10">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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            <end position="978"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
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            <end position="1009"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="86"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="412"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="732"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1053"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="661"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="665"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF13380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1296" mass="141393" checksum="5CC8C8D7102E7A29" modified="2013-05-01" version="1">MADRQGDEKALPIIAATANTPLHPADQAAIQLKPHLQSTEKGIEVDSEDDSPEGDRLSEEKGSSGSLKDYWRIFAYADSQDIACYIISLLCSVASGAALPFTTLLFGHFTTDFNNFTTGVSTPQEFRDHVDHFVLWFIYLFVARLVLCYAANVLISVAGTRTTTALRTAFLEKTLRLEIWHFDKAGNGSAATQVTTNGNRVNQGIAEKLATIVQALSLFFSSWIIALAVQWKLALICMSIIPALILVVAACLSVDAKIEARITKIYSQGAVLAQDAISSIRTIHAFGAQDKIVKTYDGYLSKAHKIGDRKSLVYGILFSTEHCLIFSATALAFWQGYRMFRSGEIDNVGTVFTVVLSVAIGTTSLSMITPQQQAITNAASAASELFEIIDQESKLDPLATDGKQPEICAGEIEVRDLTFTYPSRPTAQVLHGLNLSIPAGKTTALVGPSGCGKSTLVGLLERWYEGTGGQILLDGADISTYNTKWIRSNIRLVQQEPVLFRGTLFENVAKGLVGAQLDLPIEKKRALVADACRQANAHDFIVGLPEGYDTQVGERASMLSGGQRQRVAIARSIISDPKILLLDEATSALDPTAERIVQSALHKVSANKTTLVIAHKLATVQLADNIAVMQYGRVVEQGTHRQLIELDGHYAAMVRAQDLGASQGDAEDTNEADEKDTERQMSLQRTKISAASMTAEAELKALTSGTVGYSLVKCIYVMFTENPKLYWWYACSLFGSTIGGLLYPAQAVLFSKLISVFTLPENEGQSRANLFSLMFLVLALSNLVASFMLGWACNIIGQEVTHRYRREMLANVINFDQDFFDRAENSSGSLTSKLSSVPTSLMEMISANIALMCIVIVNVSASSILAIAYGWKLGLVVVFGALPILLGSGWVRIRMDQKLEAQAEERFADSAGLATEAVTSIRTISSLTLESAVMDEYKTTMASIIKSATRGFLVNMIPYALSQSLEFLSLALGFWYGSRLVASYEYTSEQFFVVFIAVVFGGQAAAQVFGYSTSITKAQGAANYILWLRTIVPSIGETSDNKNHGPPDTDAPIAMENIDFHYIQRHAFKVLRGISLTIHPGQYVAFVGPSGCGKSTLIALLERFYDPTSGRITLNGDDISKMSPKAYRKYMSLVQQEPPLYQGSVRENISLGLDYEPEDDEVNEALRQANGLEFVSSLPEGLHTPCGTKGLQFSGGQRQRIAVARALIRKPRLLLLDEATSALDTQSERIVQKALDEAASSRTTIAVAHRLSTIRHAHVIFVIAEGRIVEMGTHQELQALRGRYYAMCLAQSLDQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M3D5I3</accession>
    <name>M3D5I3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Emopamil-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_22268</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EBP family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761270.1">
        <property type="nucleotide sequence ID" value="XM_016908351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D5I3"/>
    <dbReference type="STRING" id="692275.M3D5I3"/>
    <dbReference type="GeneID" id="27905488"/>
    <dbReference type="eggNOG" id="KOG4826">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072128_1_0_1"/>
    <dbReference type="OMA" id="VYLWLYL"/>
    <dbReference type="OrthoDB" id="5415655at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047750">
        <property type="term" value="F:cholestenol delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007905">
        <property type="entry name" value="EBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14207:SF1">
        <property type="entry name" value="EMOPAMIL-BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14207">
        <property type="entry name" value="STEROL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05241">
        <property type="entry name" value="EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51751">
        <property type="entry name" value="EXPERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="8">
        <location>
            <begin position="42"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF13149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="247" mass="27696" checksum="C8C2259632FD4C55" modified="2013-05-01" version="1" fragment="single">TKETPSIISPTTIFSLSATLAILLAAYSASLTFLPRPTTPTKIRLLFIWHAFDALIHFILEGSYLYNCVFSSISTSSASALGHASTSKFLPPGIYFLNDPSRIYGSEFGTNPFAALWREYARADHRWEGSDVTIISLELLTVFLAGPIAVFICEKLRKNSADVWFWMTVLATGELYGGWMTFAPEWLTGSRNLVTDNFMYKWVYLVFFNAALWVVIPLWVLWEAYGRMVEGLLLVQKMEGSGSSGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M3D5Q0</accession>
    <name>M3D5Q0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_125244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761596.1">
        <property type="nucleotide sequence ID" value="XM_016901965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D5Q0"/>
    <dbReference type="GeneID" id="27899102"/>
    <dbReference type="HOGENOM" id="CLU_2929197_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF13475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="61" mass="6788" checksum="96E6B7DBD6A704BF" modified="2013-05-01" version="1" fragment="single">MARLRSITNSNLNLRRREDKADADADADNLRAQVTGDCQDIHHITNNQSINHRHHAAAAAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M3D5Z5</accession>
    <name>M3D5Z5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_125327</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761706.1">
        <property type="nucleotide sequence ID" value="XM_016901973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D5Z5"/>
    <dbReference type="GeneID" id="27899110"/>
    <dbReference type="eggNOG" id="ENOG502T2V3">
        <property type="taxonomic scope" value="Eukaryota"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="16"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="314"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="281"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="102"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="138"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
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        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="384"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF13585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="485" mass="54136" checksum="73163AC06EFC2798" modified="2013-05-01" version="1">MEDNFSIDWSNPMAMFHNDHHHHPPQHVNAGEEADGDGNHFRGPDSNLNGQTQPGALEQKAPQSTAVAASHMSAQGDDAAMKQKLENQRRAEVLRAKLIAVRQNTPIKPSTPVPTSTKAPVDAIDSSEKAPAIKVSHTQQPQQQQSKTATPQQKEEEDEEEEGEVKPTHKANEIDFEDLEALLAAGKAHADAQTAAAQHTKEMTHVAPSTGNSPGGPRDTEELELFPAKRQQLQQQHSSTDRPRVADLADVYYTDLVAWLEMTGYHDVEYRESKLRTYKERRALEDEAARIAEKLEKLRQAEQTEMQLLRMGTPGAKAPSMAPPPLPLSMVPPVNGVKRARSPEQVPAEKRQREDDGFRVRSGKELPDQHQVFARRPRSPTPASERRGSYPDATRRSIDDRGLPGSRSRDPSLERRSQYYRRDDDLRYDYFAAPRQPAPREPRSSYGNGSGVRPGWPHGREMDSNSRPSAGLDLKKGGQSSYRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M3D608</accession>
    <name>M3D608_SPHMS</name>
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        <submittedName>
            <fullName evidence="2">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_132640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016902504.1"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="OrthoDB" id="438224at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
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        <property type="entry name" value="NON-HAEM DIOXYGENASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48420:SF1">
        <property type="entry name" value="NON-HAEM DIOXYGENASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="242"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF13309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="371" mass="40707" checksum="1C421D2CAE1CDCB4" modified="2013-05-01" version="1">MGSLAPPSRPPSAVSVSLQELQNGTVSLDTLEQAFGADSLGIILVRDLPEEFVGLRRSLLSYASYLANLPREELEKVEIPAARYNVGWSCGKEKLDNGQFDTFKGSYYVQPIHSADGKPEAKARELFPHIPDMTSPNVWPSEDVLPGFEALFEKLCRLIVDVAGLVARSCDRYGVAKLEDYRDGTLENIVRGSVSTKARLLHYFPPPPKAPGSAEKGDDDWCGTHSDLGALTGLTSNMFIDESMSSPTAPDAARAPDGRLANLPELDHHPDPKAGLWIKDRAGRTTQVHIPRDCLAFQTGEALQLITRGKFRAVPHFVRGPAGVVGDDGQERKIARNTLAVFTQPNLWEIVDEKENLDFAGLAKRVFEKTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>M3D6B0</accession>
    <name>M3D6B0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_116736</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016901281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D6B0"/>
    <dbReference type="GeneID" id="27898418"/>
    <dbReference type="HOGENOM" id="CLU_2401065_0_0_1"/>
    <dbReference type="OrthoDB" id="386949at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF13715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="93" mass="9909" checksum="6BD89AED127B576E" modified="2013-05-01" version="1">MADSKAWELGLERKVSAGTSWQRRLYPTLGTSGGYATLRGLFDLLDLTGSAAVRLVSLRKMRAGSRNGASSITTFPVTSGVPVANMVFFGVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M3D6X3</accession>
    <name>M3D6X3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bis(5'-adenosyl)-triphosphatase</fullName>
            <ecNumber evidence="6">3.6.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_64734</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>P(1),P(3)-bis(5'-adenosyl) triphosphate + H2O = AMP + ADP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13893"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.1.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.6.1.29" evidence="6"/>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761745.1">
        <property type="nucleotide sequence ID" value="XM_016909691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D6X3"/>
    <dbReference type="STRING" id="692275.M3D6X3"/>
    <dbReference type="GeneID" id="27906828"/>
    <dbReference type="eggNOG" id="KOG3379">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056776_7_3_1"/>
    <dbReference type="OMA" id="DAIYGMM"/>
    <dbReference type="OrthoDB" id="680339at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047710">
        <property type="term" value="F:bis(5'-adenosyl)-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004081">
        <property type="term" value="F:bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015964">
        <property type="term" value="P:diadenosine triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01275">
        <property type="entry name" value="FHIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000011">
        <property type="entry name" value="Fragile histidine triad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051884">
        <property type="entry name" value="Bis(5'-adenosyl)-TPase_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039383">
        <property type="entry name" value="FHIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46243">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46243:SF1">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="8">
        <location>
            <begin position="4"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="121"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="5">
        <location>
            <begin position="96"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="129"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="3">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="91"/>
            <end position="94"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR639383-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR639383-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF13624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="176" mass="19663" checksum="EE92210EE7593660" modified="2013-05-01" version="1">MAKQVIKFASFNVTSQVFHTTPLSFAIVNLKPLLPGHILVSPLRIKPHLSDLTQEEISDLFNTVTRIQKTLKRVYKAEAFNIAVQDGAAAGQSVPHVHCHVIPRVKGDPGEGDKVHEWLEGEEGNVGGHQKEAETRRAAEWAKDDERKPRTKEEMDEEARWLKAEIAKDETSSPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>M3D6Y1</accession>
    <name>M3D6Y1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fungal_trans-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_148869</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761755.1">
        <property type="nucleotide sequence ID" value="XM_016905194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D6Y1"/>
    <dbReference type="STRING" id="692275.M3D6Y1"/>
    <dbReference type="GeneID" id="27902331"/>
    <dbReference type="eggNOG" id="ENOG502QQXX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006632_1_1_1"/>
    <dbReference type="OMA" id="HIFAFNW"/>
    <dbReference type="OrthoDB" id="2264294at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001080">
        <property type="term" value="P:nitrogen catabolite activation of transcription from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF4">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN DAL81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="84"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="120"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="428"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="682"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="159"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="686"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF13634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="714" mass="79487" checksum="A7B3BF482471274C" modified="2013-05-01" version="1">MATAMALPPVAPRASPRPIAAWSPPKQQQQQQQPQPQPQPQQQQQQQQQPPPPPPPPNERTEHNPPVKQLHKSPLPAKPKRERPCDGCRRRKSKCVLQDGRKCVLCEFHKQECTFVENAQPRKRKAPDDASKNGPPAKKSPIAKRRPSLPLTVAPVSIPPTTAESHPVPVSTQPPMRKPFAVDESLSLQRHRHCKYLGQTTPLDASLIGLGTFNDKNETESQLGMLRQVTSTEYFSTHDDATVPIPNDEARALKDIEHVVGTHGPALINIYFRNVHPSYPIVQKQAFLDRHRHGDRHFNPPLLAAMYLLALAWWQHDPSLAAHPKPDVARLEYIAMTSLTVAMQRPKISAVQAGLLLLQRAKASTWTLTVQLVALGQDIGLHLDCSDWSIPHWERLLRKRLAWALYMQDKWSAVMYGRPSHINASDWNVSSPTEGDFDESINPLPTPNEDSDDAESMKGRMCFMQMIALTSIMAEVCDTFYSEVAKAEFARAGRYATQLVLNRAKPVQLKLKDWIAKLPAECKMDSFSPGVLSSQGYLHLAYFATEISIHRRIVQSLNPAADPYMLYICRSAAKTRLISALDFVNRLKPEHLDAFWYFCSASNFALVGTFGALLMTTSPGKEEAHFYACRLNEFRWTLTVSSKNAAWIETALETLSATSQLLRSLPEKPAIEASPATEMQLYSGPLDGGGGGGGENVTGVEEAEGSYGSSEHTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M3D753</accession>
    <name>M3D753_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_148922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761830.1">
        <property type="nucleotide sequence ID" value="XM_016905230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D753"/>
    <dbReference type="STRING" id="692275.M3D753"/>
    <dbReference type="GeneID" id="27902367"/>
    <dbReference type="eggNOG" id="KOG1674">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052076_0_0_1"/>
    <dbReference type="OMA" id="CFLAGFE"/>
    <dbReference type="OrthoDB" id="5304883at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20558">
        <property type="entry name" value="CYCLIN_ScPCL7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF32">
        <property type="entry name" value="PROTEIN KINASE COMPLEX COMPONENT, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G07660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF13709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="302" mass="32956" checksum="EA6E1DF1547CE0AB" modified="2013-05-01" version="1">MEYGLVVVDAGPVGSPPPPPDPNVHDEAAAAPLNPTASPKSDKTLYLESESWDINSISAVAALQMLINALGGLSETTGDVPPTPPVSRPSTPGLFPRPRHQRKPSSTIPRTASSQDIPKLEIGSPEAHPHEPIMVVVGAGVEDISVQHQAIARRFFSKTAPPFTLGQYLKRFHQYCPHSPGVYLGAAAYIHQLCVSDLVVPATNRTIHRLGLAAIRIAAKSLEDNKWSQERVARMGGISTMQLMNLEIAMCFLLDFELYLDERIMARRMFLLQSAARKGFGVQGGLSEQFKLRLPMRRKGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M3D804</accession>
    <name>M3D804_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidate cytidylyltransferase, mitochondrial</fullName>
            <ecNumber evidence="6">2.7.7.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">CDP-diacylglycerol synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">SEPMUDRAFT_147859</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TAM41 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="6"/>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF13994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762115.1">
        <property type="nucleotide sequence ID" value="XM_016904558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D804"/>
    <dbReference type="STRING" id="692275.M3D804"/>
    <dbReference type="GeneID" id="27901695"/>
    <dbReference type="eggNOG" id="KOG2986">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030279_0_0_1"/>
    <dbReference type="OMA" id="KQTVNWP"/>
    <dbReference type="OrthoDB" id="341477at2759"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015222">
        <property type="entry name" value="Tam41"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13619">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13619:SF0">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09139">
        <property type="entry name" value="Tam41_Mmp37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="17" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="47"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="551"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="563"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="574"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="584"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EMF13994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="609" mass="68322" checksum="A7EB4726888854F6" modified="2013-05-01" version="1">MSLTQKLAKSPVFHSLLGANSFFLADAAWQSRPAYVRSTYPTRSFSLGRTLRDQKEAQPSSPIDSTESAASSSSDNGSRSGSDGSSVRKQKSAQLDKMKKKNSASGDAAGAESTAADSPMQSLPPGWEENADYNISNFSDLPHRFFGYNQHIKINEDFKESLRQVLWQFRAPIRYAFAYGSGVFGQKSSSSSTAGESLSPHPNPPKAVEDWQKGGAKIIDFVFGVSHTQHWHSLNLQQNPHHYSGLRHMPFSSGLVSWMQDGWGAGLYYNPYITVNGIMIKYGVVHLDTLAKDLTDWNTLYLAGRLQKPVKILRDDPRIRLSNQVNLISALRTALLMLPEQFTEKQLYERITSLSYLGDPRMHSMIASEAPNKVSNIVGAQLPGFRQLYVPLIENLPNVNFTDPRTPHFYGWEKEDAIRHTGTISQLRDVLGGQDGLTLTQDMDPQKRGNMVRRLPQDFRRKLYYQYMKKFQLPGSAFDDILKSQEDEDPTGFKRREGGSFEKRIASSHDLPEVMATCVKKTVAWPAAMQSVKGVFTSGLTRSIKYVGEKRSKGKAKKAAAAEMKKEGVRVEEASEEKEEESPAAEKRRQLLKEEAEDDEKTNYKKRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M3D8Z2</accession>
    <name>M3D8Z2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Galactose mutarotase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_83057</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldose epimerase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762736.1">
        <property type="nucleotide sequence ID" value="XM_016910326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D8Z2"/>
    <dbReference type="STRING" id="692275.M3D8Z2"/>
    <dbReference type="GeneID" id="27907463"/>
    <dbReference type="eggNOG" id="KOG1604">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031753_0_0_1"/>
    <dbReference type="OMA" id="NWATYQF"/>
    <dbReference type="OrthoDB" id="274691at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09019">
        <property type="entry name" value="galactose_mutarotase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047215">
        <property type="entry name" value="Galactose_mutarotase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091:SF6">
        <property type="entry name" value="1-EPIMERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G13240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091">
        <property type="entry name" value="ALDOSE-1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004033154" evidence="4">
        <location>
            <begin position="19"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF14615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="400" mass="43029" checksum="66A41F9495D0A27D" modified="2013-05-01" version="1">MFVASGTAVLAAAALVSAQAGYGSASASPFAPFSGDPFQKYELSANGISATFIPYGARLTSLVVNDKNGNPQDVAVGYDEGARYLEDTETNHTFFGAVVGRYANRIKNGTFAIDGVQSDIPKNEHNGTNTLHGGLVGYDQQNWTVAALSKSSITFTFYDEAQQGFPGDVLNVGTFTLEDDQTFTSRLVSIPFNDATPIMLSHHIYWSLGAYVNEDALTILNDTLYLPYAKRYIQTDGILIPNGSIAVTKGTGLDFTQPDTTIGSNIPNTAGFCGTGCTGIDNAFITDRAPSTGVQDKGLEVLRMWSPHTGIQLSVETDQNGIQIYTCVGQNGSIKLKKSQQHIAGQDAALEKYGCIVIETQDWIDGINHPEWGREEYQIASATTPPIVNFAKFKFSVVNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M3DBA2</accession>
    <name>M3DBA2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_123496</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to mitochondrial small subunit 15S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763250.1">
        <property type="nucleotide sequence ID" value="XM_016901844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DBA2"/>
    <dbReference type="STRING" id="692275.M3DBA2"/>
    <dbReference type="GeneID" id="27898981"/>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011174_0_0_1"/>
    <dbReference type="OMA" id="HAWSIRI"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF17">
        <property type="entry name" value="OS12G0638900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="555"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="700"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="33"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="964"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF15129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="984" mass="109127" checksum="25E69F23431243D5" modified="2013-05-01" version="1">MSVPYICSACRLAPLTRTVRGTARHLRTLSQAIASNGTREDGDGDHNGIGDGDGSGSGIGYTVRGRYSGRELRPEQPYTPFHHAPPEPPRSRLVGTGSTQRANRPAPQRPHQTDDHANDNAFAIPTHVMNVVNELSGYSTAEDWPSTWRVLQKLARIYSEGNPRHAARFLNISGVSRIVSILLHRSIINLMDSIRTGDVDSAMPTPYRIMLLLHQAYVSKTLYVRPVLSRLSDYLWTYQAGRRADIHDQRLSNGVNELMGIWRLCIGGSLSNKSLGDVREAKARAFASVATSEEDWSFLPAVAAFTSLHERDSSTAFEQMLGLLVPPTDVKQGFPARGDYASAALLTVDLLNKTVQPSEDGQNVPMATLARYAPFAEIIAEMLGIAASPRVPPELELKLTLKADELGLEQLKAMLARVGCEGYSANVTSVARSSQTPARSPPSVRVGIPARVENPTSFDDTEQLSPEVKAAERPAVESYAGEKIYRLLKAMEGQGVAQVAKIVREVQEYASTLSHGEVLPIDLYEHMLLATLSVRDTKTAVEVWQNMAQLGLEPTVKTYTVMMRGSQNARDVKGMEAFFQRMRQAGLRPDAYSWSIRIFGLLKLRNVSTGMRALSEMGQEWFAAAKAKAVSEGLPADTNWMASNKNMVSELMKRYPGPVDGVPRPNLEVMNAAMAALATTRPDEVPKVFSWGRSFGIEPNLATFNTLLSISMKQHRPTDALEVLQQMQGRGLEADSTTWTVIVTSLFEGGFLEGLSPSAQQTKILNFIDALSDKSEKLPGINSMGYALIIDRLIKHYQNHTAAAAVYSHMLSRGLKPTTHIYTILMGSYFDREHLQPDFAAIEALWQQITHSELLTGIDGIFYDRMIEWYARYHHLVGVQPMEKFLTLSRASSKKPGWKALESVARVYAARHMWDKMRNLVDAATIDMRDQQGRISKTGERQFWDFVHSTGLLRQEGYLSRDDFNRDRPVGSPLERAERAVQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M3DC53</accession>
    <name>M3DC53_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Poly(A) polymerase</fullName>
            <ecNumber evidence="11">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SEPMUDRAFT_60694</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Polymerase that creates the 3'-poly(A) tail of mRNA's.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11332"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17347"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173115"/>
            <dbReference type="EC" id="2.7.7.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 2 magnesium ions. Also active with manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="11"/>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763761.1">
        <property type="nucleotide sequence ID" value="XM_016909536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DC53"/>
    <dbReference type="STRING" id="692275.M3DC53"/>
    <dbReference type="GeneID" id="27906673"/>
    <dbReference type="eggNOG" id="KOG2245">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011511_4_1_1"/>
    <dbReference type="OMA" id="PAYPAMC"/>
    <dbReference type="OrthoDB" id="412748at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071920">
        <property type="term" value="C:cleavage body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033620">
        <property type="term" value="C:Mei2 nuclear dot complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990251">
        <property type="term" value="C:nuclear exosome focus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180010">
        <property type="term" value="P:co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033621">
        <property type="term" value="P:nuclear mRNA surveillance of meiosis-specific transcripts"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000002">
        <property type="entry name" value="Poly(A) polymerase alpha, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.10:FF:000001">
        <property type="entry name" value="Putative poly(A) polymerase gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.590">
        <property type="entry name" value="Poly(A) polymerase predicted RNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011068">
        <property type="entry name" value="NuclTrfase_I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007012">
        <property type="entry name" value="PolA_pol_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048840">
        <property type="entry name" value="PolA_pol_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007010">
        <property type="entry name" value="PolA_pol_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014492">
        <property type="entry name" value="PolyA_polymerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682">
        <property type="entry name" value="POLY A POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682:SF10">
        <property type="entry name" value="POLYNUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04928">
        <property type="entry name" value="PAP_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20750">
        <property type="entry name" value="PAP_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04926">
        <property type="entry name" value="PAP_RNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018425">
        <property type="entry name" value="PolyA_polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55003">
        <property type="entry name" value="PAP/Archaeal CCA-adding enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) polymerase nucleotidyltransferase" evidence="17">
        <location>
            <begin position="10"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase central" evidence="16">
        <location>
            <begin position="211"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase RNA-binding" evidence="15">
        <location>
            <begin position="359"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="547"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="446"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="592"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="102"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="238"/>
            <end position="239"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR018425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR018425-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR018425-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF20750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMF15640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="607" mass="68373" checksum="C35645B20F602AF7" modified="2013-05-01" version="1">MASQTAEYLGVSPPLSTEPPKPRDNELHDQLLAELKAQNNFESPEETAKRQNVLVKLQKLLLQLVQRVGKKKGLNPELLKEAGGKIFTYGSFRLGVYGPGSDIDTLMLSPKHVTREDFFEYMPDMIRQAIPAEDITELVPVPGIGVPIIKTEIEGISIDLIWCTLHKDRVPPNLELNDSELLRGLSETDLKCVNGTRVTDRILSLVPQTRTFRIALRAVKMWAQKRGLYGNVYGYPGGVAYAMMVARVCQLYPRAAASTIVAKFFWVVKNWQWPSPIYLQAREKGPSLNQQEWDPQKNFRDKRHLMPVITPAYPVMNATHTITRSTKEVLIRELNRGHEIMADIYSGKKQWRDLLIKHEFFTSAYQHYIVIVTASKTKDDQQAWAGLVTSRLRFKLVEGIEDSADKVNLVQPFNKGIERHHKCKTKEEIESVLGGGLDGLVEKATTTEETADAKQQAAAEGDADVINDMAATNDDAESKDKKKDDSELELWTTTFYLGIELLKGEKNLDISYSVNDFKGNVQLWPGYNPDVHSVQIKYYRDYQLPPDLFSEGEKRPVRKIKKSKKENLEKKRSVSNAGLDENQNPAKRRQSGPVNGTGTPITNGAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M3DCG0</accession>
    <name>M3DCG0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">rRNA biogenesis protein RRP36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_39577</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Associates with 90S and pre-40S pre-ribosomal particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
            <location evidence="1 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the RRP36 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763615.1">
        <property type="nucleotide sequence ID" value="XM_016908750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DCG0"/>
    <dbReference type="STRING" id="692275.M3DCG0"/>
    <dbReference type="GeneID" id="27905887"/>
    <dbReference type="eggNOG" id="KOG3190">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048802_0_1_1"/>
    <dbReference type="OMA" id="HMKSKQR"/>
    <dbReference type="OrthoDB" id="4463286at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009292">
        <property type="entry name" value="RRP36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21738">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21738:SF0">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06102">
        <property type="entry name" value="RRP36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 10" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 10" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="45"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="218"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="270"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="58"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="222"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF15494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="307" mass="35575" checksum="8DC94540F30D6D93" modified="2013-05-01" version="1">MDEDEVEDETEDETGDEVEVKAPGEEFHSGEAELQIRHVSFGALQQAQDAVSKKRKRTSDAHLDQDDKLAALRDRLRQIKAQKTEKPSKEKKVSGRTKNAKSIARDGDDDGDDSDDSDSDSGPSEEDVPNKSRTSKHAPTAQSTKYQVSRKRQVVDVPKRNVRDPRFDAFHQHAEPSNTDKAYSFLDDYQRDEIKELKAEIKRTKDEDDKQILRRKVNSMENRLKAKAAKEREQEVVRRHRKEEKARVEEGKTPYYLKKKEIKEQALVEKFKGMKSKERQKLIDKRQKKESQKEKKRMPDARRMASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>N1QD95</accession>
    <name>N1QD95_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_128004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757372.1">
        <property type="nucleotide sequence ID" value="XM_016902185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QD95"/>
    <dbReference type="GeneID" id="27899322"/>
    <dbReference type="HOGENOM" id="CLU_2607534_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="79" mass="8817" checksum="F23C18539C90A732" modified="2013-06-26" version="1">MYDASTSCGIPTYHPGVEWSLWPSDLSRSDFSEKTNVEGRLEDACELWNSLLTTKLNQSQRGLMRARAGRRAPPTMGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDP3</accession>
    <name>N1QDP3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sec7-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_166282</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757752.1">
        <property type="nucleotide sequence ID" value="XM_016908216.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.N1QDP3"/>
    <dbReference type="GeneID" id="27905353"/>
    <dbReference type="eggNOG" id="KOG0928">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2551">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001204_3_1_1"/>
    <dbReference type="OMA" id="CRDIRHH"/>
    <dbReference type="OrthoDB" id="10258608at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056604">
        <property type="entry name" value="GBF1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF388">
        <property type="entry name" value="GOLGI-SPECIFIC BREFELDIN A-RESISTANCE GUANINE NUCLEOTIDE EXCHANGE FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23325">
        <property type="entry name" value="TPR_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="2">
        <location>
            <begin position="625"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1304"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1325"/>
            <end position="1338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF09631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1872" mass="207567" checksum="A0F9B6FAA6243E1A" modified="2013-06-26" version="1">MASIPVAIDPVSLVVTECITVTSAMRKHARWAHSSISSILGSSPSSHTRTTSSDLSSQRSNRERERTRASSKIDLIEPYFSDYNSASGTRASEEASRWGLRGKKGQSMQDNPLMSAFAKLRSELKGVKDIQTIPTPDLLHPFLQVIRSSSTTAPITSLALIAITKMLAYRVVHEECPKFAHGMQLLASSVTHCRFEGDNSPSDEVVFLRILKLMEDMICGASGNVLGDQSVCEMMECALSICCHLRMSEVLRRSAEISMVTMCQTIFGRLKTLEAEFEGDEVGDMEQELGSEEMEAAKIDSNGDMGPDNMKQMRSSLTLDVPATNTEARPSTDMNASQMDLSSRSGEEDEEDVDVKPYGLPSIRELFRVLADLLDPHDRQRTDTLRVMALRIVNVALEVAGPSIANHPSLANLAKDTLCRNLFQLVRSENIAILHESLRVAGTLLATCRSVLKLQQELFLSYVVACLHPRVPIPDEPNVDPSLYQGVPQAPTLARPQPSTPGSNGPPASGRSTPVPVRDRQKLGMEGGSRKPDAREAMVESVGGLVRMPSFMTELFVNYDCETDRSDLCTDMVGLLSRNAFPDSATWSTTNVPPLCLDSLLGFVQFIAERISDEPVTTGLPEVEKLREQRRKKKVIIRGATKFNESPKGGIAFLAAQGIIADPNDPHSVTSFLKGTTRIDKKVLGEFISKKSNEAILDAFMDLFDFGDLRVDEALRQLLNSFRLPGESALIERIVTVFCEKYMRAVRPEQIIDVDSAFVLTYAIIMLNTDQYNPNVKSANRMKFEDFQKNLRGVNGGKNFDEEFLQEIYEAIKAREIVLPEEHDNKHAFEHAWKELLMKVNTAENLVICETNIYDADMFAATWKPIIATLNYVFVSATEDAVFQRVIAGYNQCAQIAARYGVSECLDYIILSLAKISTLATETPPSTSLNTEVQASGKSIMVSKFAVDFGRDNKAELATIVLFRIINGHEGAIRDGWTQIVRIIVNLFVNSLVPTSFTSISRDLDLPPIPLQSPAQVIERNDKRNDVGLFSAFTSYVSSVMNDEPPEPNDQEIEATLTSVDCINACRFEEILGNVSELPVSTLKSLTMSLLSHLPEQDSPRVIAVKPELPAPTPLRGTGSKVRDEPPMYNPAVVYVLELATILALRDEETITTLGPDVAEALTSVTRDADRLHPVALSRTVFYLLSLLRASNDHGYIRAPVVLHAISSFPQHLLKQCALPILKGIYGCISGPQTELRNEMAASPDFWNIVHNLHHEVEAAGLVFQIVESVVDGPNAAITPDNYEACVALLNAFATSGSIGARAEQAARGEKYPQSGRKGQKQPPRKTDSTEDEGTPEKKKVKKLEVVVRGNRAITLVSHLAGRVPHLIKQSQLETEEAWKAYWSPVFRCLATQSTNPCREIRQLSLSSLQRCLLSPELASPDHTEWTNIFSEVLFPLIQQLLKPEVYQTDPVGMGETRVQAAQLLCKIFLHYLVLLSEWPGVGELWSGILEVMERLMGSGQRDGGILEEAVPESLKNILLVMGSGGYMVPPPAEGDDERSELQRKLWQETEVNLERFLPELMKEVFPESVNRQTKQKTLTISTSRLLRSQEILPTMTAAAARTSSKLRVLCLHGYTSNSQVHAHQLRRLTSALSSDYEFLFPDGPHKVDLSSSSPTSAMDMSKPANQVWHELVQGLSPRSAEIGHRAWWFARDPEWKTKRQGRFEGLEETFEYLGRWLREHGGPVDAVWGFSQGGCLAGMVVALLQNSQRGHVLRRKLGVDDDGSDDGSTEVKAGVVFAGFRARFEVYDDVYEPYGIETPVLHVMGNQDPLVDSERGEALMRVCKREEVLRFEGGHDIPKGEREVERIVAFMRRYVDAGRGREKSGKEQASM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDV5</accession>
    <name>N1QDV5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_150503</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758476.1">
        <property type="nucleotide sequence ID" value="XM_016906222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QDV5"/>
    <dbReference type="STRING" id="692275.N1QDV5"/>
    <dbReference type="GeneID" id="27903359"/>
    <dbReference type="eggNOG" id="ENOG502R8V2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_455763_0_0_1"/>
    <dbReference type="OMA" id="HANTTQV"/>
    <dbReference type="OrthoDB" id="3922255at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="343"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="616"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="675"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="563"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="91"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="148"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="167"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="397"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="449"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="461"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="486"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="499"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="520"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="616"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="681"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="707"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF10355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="718" mass="78052" checksum="3DD8E14DDB6F5C61" modified="2013-06-26" version="1">MPHPKPAQVADYDSDEGRIVSGTEVSAHTSRSSKHRPSSSSKPPKQGGGGAAAVAAGAGPAAGGAGGGGGGGERASRSATPHVPASDSGYSSTPAADTKPATSTATATATAAAAAANSPAKPAQSTSSPAVAPSPVKSKPIIHRQDSARSTTRAATISNTTAKRKDHCTDPNCRDPNCDSTRNLERRYTNPNREHRNSMSAALPPAQAQYHYYPQQQQQQQQHDYAAMPPPSAMPLARRESMVHPRPHSLHMPHVSAGLPLSYPVVHPGATPGYGYGHPQASYAPQQPVVYGTAPPTQQAVYPPPPSPVKAAVPSSPLTGTYPGYPGQLGKISARTGNPAVPGLVTSIPMQPPAPAYNVSAGGGMSARADRRTKNHAAEQRRLRDDENTSSESESSGDERNQDARYDYHRDEQDRRREPKRIEYERQRSKSRRRRSVVIEDPRPVAKKSYTTSVVPTRQSSRRDSISRPDLNHRTTSDPLVEYVSSPDTYESSHPSKAVLDRRERDRRDAASAKRHSRRMSVSTTADSYDTPPTSISNGSGYVEAIIEDRGGSRRVYLSREQYAELTRRYEREDREAERDRLEAQRMHLERIERYQKEQAAGVERQNLTATNIKEAARTTTKSHVSSRSQKTTTSGSRLSRGGLTLERNGTMLYLEEGIPEISLKLDDDGHTRVVIGSGTNGREQSYHGSKSSGSRVGRPRTSRQHSIREEEQYERGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>N1QE61</accession>
    <name>N1QE61_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">U-box-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_150663</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758741.1">
        <property type="nucleotide sequence ID" value="XM_016906321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QE61"/>
    <dbReference type="STRING" id="692275.N1QE61"/>
    <dbReference type="GeneID" id="27903458"/>
    <dbReference type="eggNOG" id="KOG4642">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056455_1_1_1"/>
    <dbReference type="OMA" id="WAGVEHD"/>
    <dbReference type="OrthoDB" id="629492at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045862">
        <property type="term" value="P:positive regulation of proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46803">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CHIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46803:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CHIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0697">Rotamase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="6">
        <location>
            <begin position="216"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF10620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="294" mass="34114" checksum="C70165521632A8AB" modified="2013-06-26" version="1">MSYLADALKEKGNHAFREGDYHAAEDFYTQAIQKYSKNPLIFTNRANARLKLQKWDDTVNDCLKSIEITGPNGQNHKAWYFLAQAQLALHHPHEALSSALKAYEQVLHPAPAAKTSPSDLQTFSAFVLRCKKEKFRARDRERLRRQGELRAELEEMLEKQRQQDLDLVAEELHRGKLGQVEASERSEEVRGNYEKKINSLRTVFEIAEPQNNTPREIPDHLVDMITFEPMHDPVITKNGHSYERATIYEHLKRTPTDPLTRDSLKKEDLRSNFGLKAACDEFWDSGAREWIIDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1QEA7</accession>
    <name>N1QEA7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">threonine synthase</fullName>
            <ecNumber evidence="4">4.2.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_151358</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the threonine synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="4"/>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757388.1">
        <property type="nucleotide sequence ID" value="XM_016906761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QEA7"/>
    <dbReference type="STRING" id="692275.N1QEA7"/>
    <dbReference type="GeneID" id="27903898"/>
    <dbReference type="eggNOG" id="KOG2616">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015170_1_0_1"/>
    <dbReference type="OMA" id="NFERYLY"/>
    <dbReference type="OrthoDB" id="5203861at2759"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01560">
        <property type="entry name" value="Thr-synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000024">
        <property type="entry name" value="Probable threonine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1380.10:FF:000003">
        <property type="entry name" value="THR4p Threonine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1380.10">
        <property type="entry name" value="Threonine synthase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029144">
        <property type="entry name" value="Thr_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037158">
        <property type="entry name" value="Thr_synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051166">
        <property type="entry name" value="Threonine_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42690">
        <property type="entry name" value="THREONINE SYNTHASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42690:SF1">
        <property type="entry name" value="THREONINE SYNTHASE-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24857">
        <property type="entry name" value="THR4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14821">
        <property type="entry name" value="Thr_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Threonine synthase N-terminal" evidence="11">
        <location>
            <begin position="9"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="10">
        <location>
            <begin position="97"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR604450-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF09267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="555" mass="61474" checksum="944914524C578F48" modified="2013-06-26" version="1">MVAHSPSQRYLSTRGGSYDLSFEEVVLKGLASDGGLFIPEEIPQLPSDFLAQWKDKSFQELAFEIFSLYISPGEIPSADLKNIIQRSYATFRAPDITPLQTLDAQKKLHLLELFHGPTFAFKDVALQFVGNLFEYFLVRRNKGKEGDAREHLTVIGATSGDTGSAAIYGLRGKKDVSVFIMYPKGKVSPIQEAQMTTVTDANVHNLRVEGTFDDCQDIVKTLFADSELNATHRLGAVNSINWARILAQITYYVHAYFSLAKQTGSTDPTARFVVPTGNFGDILAGYFATRMGLPTDKLVIATNENDILHRFWKTGYYEKQAKHGREAEGGGAEVEDGAKADPSGVKMTFAPAMDILVSSNFERLLWYLAFQTSKTEETNRRRMEAGAKVKDWLEALKKDGGFGVEKEILQAAMQDFESERVSDKHTIDTIKEVYGWSSIPAASNPVVATTGMLHNGHYILDPHSAIGVAASLRQAQNVSKETHLVSLATAHPAKFSHAVELALKDVPGFTFETVLPEQFIGLDQLERRITESKADWKQVRGIVVQQVADELKGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>N1QEC3</accession>
    <name>N1QEC3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GMP synthase [glutamine-hydrolyzing]</fullName>
            <ecNumber evidence="4">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">GMP synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Glutamine amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SEPMUDRAFT_135733</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the conversion of xanthine monophosphate (XMP) to GMP in the presence of glutamine and ATP through an adenyl-XMP intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>XMP + L-glutamine + ATP + H2O = GMP + L-glutamate + AMP + diphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:11680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="4"/>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757418.1">
        <property type="nucleotide sequence ID" value="XM_016902729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QEC3"/>
    <dbReference type="STRING" id="692275.N1QEC3"/>
    <dbReference type="GeneID" id="27899866"/>
    <dbReference type="eggNOG" id="KOG1622">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014340_0_5_1"/>
    <dbReference type="OMA" id="IWQSFAV"/>
    <dbReference type="OrthoDB" id="1724632at2759"/>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003921">
        <property type="term" value="F:GMP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01742">
        <property type="entry name" value="GATase1_GMP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01997">
        <property type="entry name" value="GMP_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000002">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000001">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000001">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00344">
        <property type="entry name" value="GMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004739">
        <property type="entry name" value="GMP_synth_GATase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022955">
        <property type="entry name" value="GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025777">
        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00884">
        <property type="entry name" value="guaA_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00888">
        <property type="entry name" value="guaA_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000848">
        <property type="entry name" value="PRK00074.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11922:SF2">
        <property type="entry name" value="GMP SYNTHASE [GLUTAMINE-HYDROLYZING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11922">
        <property type="entry name" value="GMP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00958">
        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54810">
        <property type="entry name" value="GMP synthetase C-terminal dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="8 16" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 16" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMPS ATP-PPase" evidence="17">
        <location>
            <begin position="217"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="245"/>
            <end position="251"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMF09297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="545" mass="60092" checksum="379C96FF675B79A5" modified="2013-06-26" version="1">MAVNGTTNGELPQAPHKLFDTILVLDFGSQYTHLITRRLRELNVYSEMLPCTQKLKDLDFTPKGIILSGGPYSVYSPDAPHVDEAVFQLDVPILGICYGLQELAWHHGKGVAAGEKREYGKATLQLQKHAGKSAHIDKLFEGLENEVVWMSHGDKVSRLPDNFHTIASTANAPFAGIAHDTKNLYGIQFHPEVSHTPKGIQLIKNFAVGICKAQTNWTMGAFVNQEVERIRTLVGDKQQVIGAVSGGVDSTVAAKLMQTAIGDRFHAVMVDNGCLRLNEAVEVEATLKEGLKVNLTVIDAKDRFLGKLAGVSDPEKKRKIIGNEFIEIFQEEAKKIAARAENTDRAGKVEWFLQGTLYPDVIESISFKGPSATIKTHHNVGGLPEKMDLKLIEPLRELFKDEVRALGTELGIPENLVWRHPFPGPGLAIRIIGEVTTDRIRIAQEADKIWIEEIRKAGFYREISQAYAAVLGVKSVAVVGDQRLHGEIVHLRAVQTTDFMTANVFTGAPMDWFASVSDRIANEVQGVARVVYETTSKPPATIELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFD3</accession>
    <name>N1QFD3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Serine/threonine-protein kinase BUR1</fullName>
            <ecNumber evidence="4">2.7.11.22</ecNumber>
            <ecNumber evidence="3">2.7.11.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Serine/threonine-protein kinase bur1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">SEPMUDRAFT_108731</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="4"/>
    <dbReference type="EC" id="2.7.11.23" evidence="3"/>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760023.1">
        <property type="nucleotide sequence ID" value="XM_016900750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QFD3"/>
    <dbReference type="STRING" id="692275.N1QFD3"/>
    <dbReference type="GeneID" id="27897887"/>
    <dbReference type="eggNOG" id="KOG0600">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_181_21_1"/>
    <dbReference type="OMA" id="ENMPGWK"/>
    <dbReference type="OrthoDB" id="28397at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070691">
        <property type="term" value="C:P-TEFb complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070693">
        <property type="term" value="C:P-TEFb-cap methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:intracellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000562">
        <property type="entry name" value="Serine/threonine-protein kinase bur1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000514">
        <property type="entry name" value="Serine/threonine-protein kinase BUR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF233">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="30"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="347"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="403"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="440"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="460"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="484"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="518"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00073250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EMF11902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="625" mass="71116" checksum="F6206CC7C0E66C14" modified="2013-06-26" version="1">MSQGASPSASGMTDPTQRRFRGSGKITDYEIMKEKLGEGTFGVVSKAKSKRTGAVVALKKILMHNEKDGFPITALREVKLLKMLSHPNILRLEEMAVERQQGDDKGKSGKKRATLYMVTPYMDHDLSGMLTNPDIRFTDAQVKCYMLQLLEGLRYLHDSHILHRDMKAANILISNKGILQIADFGLARHYEGDTPVPGQGNGKATRDYTSLVVTRWYRPPELLLTLKRYTPAIDMWGVGCVFAEMFERKPILEGRSDIDQCVKIFKLLGSPTQENMPGWNELPGCEGTNVWEKQRGDIDHRFRNIGPEGLHLLKSMLCLDWRKRINAIDALQHDYFKVKPLPARPEEIPRYEDSHELDSRRRGKQDNQRALPPAPAGGTVGMGPDEWGHGPPNGAYQNGYNDRGGRNYGRDRGPPGAAYPQSRYDDRRAPPLPMGGRQPAYRDRDSRERQLPPANGHSLPPRPPIDLPPRPPVSIPDRGGIPDRAPPPPLAGPPPGRRDLGPNVDTYIPSYQGGGRSYDNRPPRPRDDYDRPARRDSRDRDLAYRDADGPPRYRDPDAPGPRTYRDMDAPRPDRGDDPYRDRDRRRDYPPPPPEARRTRSRSPDRERRERTERLQHREREMYSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFI4</accession>
    <name>N1QFI4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_149792</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760098.1">
        <property type="nucleotide sequence ID" value="XM_016905771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QFI4"/>
    <dbReference type="STRING" id="692275.N1QFI4"/>
    <dbReference type="GeneID" id="27902908"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_0_1"/>
    <dbReference type="OMA" id="NAMPWFS"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF29">
        <property type="entry name" value="BENZOATE-PARA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF11977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="522" mass="58389" checksum="F6BAC491261F26CE" modified="2013-06-26" version="1">MTMAFQKYLVIAAVLAPVWLVLYYVLPYFTTYKHLQDIPGPFLAKFTNLWLALGARNGKKFAWVDYAHKKYGKVVRVGYNHMSIAEPEGLQTVYAHGNGFLKDHFYEAFVSGVPGVFNVRDRAEHTRKRKIIAHAFSPSSVHAFETHMAGNLRRWVEQLDRISSQPTERTGFARINMMPWCTYIAFDIIGDLAFGAPFGMVSKGKDECEAQLEPNGPIVLAPGAETLNRRGEVSSTLGLLLPLRPWAKYLPDPFLRKGLESVRNLHGIATVAVNKRLQASEKGQHQSERHDILDMLVNAKDSSGNPMSQDELVSEALTQLIAGSDTVSNTAAATFYWILHGERAAPGSIVPRLQAELDSTIPADAEIASHDQVKNLPFLRRCIDEAMRLHSTSAIGLPRIVTSAGVSYQGTFFPRGTVMSVPSFSIHHDADVWGPDVEEFKPDRWLPENLTPRQKICFNPFSFGPRACVGQNVAHMELALIVGTAFHRYDFELYQQQIESHEGFSKKPDEVWLGIRKRSSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1QG12</accession>
    <name>N1QG12_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GA4 desaturase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_119223</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758813.1">
        <property type="nucleotide sequence ID" value="XM_016901490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QG12"/>
    <dbReference type="STRING" id="692275.N1QG12"/>
    <dbReference type="GeneID" id="27898627"/>
    <dbReference type="eggNOG" id="ENOG502SKC4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042688_4_1_1"/>
    <dbReference type="OMA" id="AGCIHCS"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF3">
        <property type="entry name" value="OXIDOREDUCTASE AN1597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF10692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="330" mass="36943" checksum="E5D0E7158023DDB0" modified="2013-06-26" version="1">MASINPTGIFRFVEPDLTIPAQDRAIFANPRPKHLVQLELPLHDIRTSNEISAGSAGLDVQGFTYLHHVSALSPEQMLEGRNAEDVLAPETLEMMIKYTGAKRGVVHSVGFRRIPASKQLDLEFVPLRGSEIDVAMERIPKDQMLVSGRDEHSASEPARQCHVDMTLEGLRQTLRYSTTEIVTAAKNIIEAEDLRAAGHDVPVPRYAAYSVWRPLKPVHRDPISILDYRTLSPSELIPTENRIPSGITAEGDYIIQAYTASPPKRPELQKWYWMPEQKPHEVLVIKFADSAAEGDPGVAKCGVHVSPILPGTEREEVRESCEVRVYLFWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1QG48</accession>
    <name>N1QG48_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tryptophan--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Tryptophanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_134152</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>tRNA(Trp) + L-tryptophan + ATP = L-tryptophyl-tRNA(Trp) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9671"/>
            <dbReference type="Rhea" id="RHEA-COMP:9705"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78535"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="3"/>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760388.1">
        <property type="nucleotide sequence ID" value="XM_016902612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QG48"/>
    <dbReference type="STRING" id="692275.N1QG48"/>
    <dbReference type="GeneID" id="27899749"/>
    <dbReference type="eggNOG" id="KOG2713">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029244_1_1_1"/>
    <dbReference type="OMA" id="PNHIRIE"/>
    <dbReference type="OrthoDB" id="15808at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070183">
        <property type="term" value="P:mitochondrial tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000082">
        <property type="entry name" value="MSW1p Mitochondrial tryptophanyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000002">
        <property type="entry name" value="Tryptophan--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00140_B">
        <property type="entry name" value="Trp_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024109">
        <property type="entry name" value="Trp-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050203">
        <property type="entry name" value="Trp-tRNA_synthetase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43766">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43766:SF1">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00069760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF12267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="385" mass="42950" checksum="24781D7EB4B684B3" modified="2013-06-26" version="1">MSSALSNRGGSVRRLLTANGPQYGAVRRRRTRRSFWSTATETPSKIIFSGIQPTGVPHLGNYLGALRQWVKLQDEADDNNTRLIYSLVDLHAITIRQDPAQLRQWKKESFAMLLAIGLDPERSTIFHQSDVAAHTELMWILSCQASTGYLSRMTQWKDKTSNEKDGHEKLKLGLFSYPVLQAADVLVHGTTHVPVGHDQAQHLEFAREVANGFNHQYGANILTPPETIISPAKRVMSLTNPVSKMSKSDRNPKSRILLTDSEEVIKQKVKSAITDSLSGISYNPPLRPGVSNLIDLIYHASGYDTSSAGNQEDLAREMENMTMRVVKDRAAQAVNDLIRPIRERYTEIMEREGEELEGIAKAGAEEARNSAEVTMKAVREAVGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGF7</accession>
    <name>N1QGF7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_150880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759053.1">
        <property type="nucleotide sequence ID" value="XM_016906450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGF7"/>
    <dbReference type="GeneID" id="27903587"/>
    <dbReference type="HOGENOM" id="CLU_2249336_0_0_1"/>
    <dbReference type="OrthoDB" id="3911445at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF10932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="107" mass="12351" checksum="8CDB9ED8344ABA6C" modified="2013-06-26" version="1">MSPIARSAIKLTQKLRDSAYRTQMLDLVQEAINKPELAHFTVATFKNASHTSPSDPREHATVFLATEEQAKNNKAQAVHIYHDKDYKFTGYSLWQERENREDKTKDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGG6</accession>
    <name>N1QGG6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Membrane-associated proteins in eicosanoid and glutathione metabolism</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_150883</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759063.1">
        <property type="nucleotide sequence ID" value="XM_016906452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGG6"/>
    <dbReference type="STRING" id="692275.N1QGG6"/>
    <dbReference type="GeneID" id="27903589"/>
    <dbReference type="eggNOG" id="ENOG502SRDN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129387_0_0_1"/>
    <dbReference type="OMA" id="IQAIAHN"/>
    <dbReference type="OrthoDB" id="4456959at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="146" mass="16173" checksum="5D1C64712F4B2905" modified="2013-06-26" version="1">MSSTLGLGPHPLLQPITALAGWTFLMQSWMHVTRINAIGKYNVSIDASKINSELESKVPNNIQAIAHNYNHLHEQPTVFYAVALALAVVGDNHPYTIKAAWTYVGLRVGHSLYQVFVNRVLTRFQIFLSSSVVVAGLWGRLATLVF</sequence>
</entry>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">SO2202</strain>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR39615:SF1">
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    </dbReference>
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    </dbReference>
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        </location>
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        </location>
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        </location>
    </feature>
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            <begin position="17"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="140"/>
            <end position="153"/>
        </location>
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            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="187" mass="20826" checksum="40DE07D2D93D11C1" modified="2013-06-26" version="1">MASYQYGMPTYGAHAQNHQHHAGGRSRRGPRVSSSNAQRQYRAQKSPKEEAPQVQTYNDYLRVLEAARGFDFDDDEVFCPFDLLTEDDLQSIHSSSASDRGSLSSGSPEGSPLQQQVQPTSSLLLPSIPTSYTPVNYHQAQTKLHQPMAQRNRNAIPIVDPSTRSASSVSPGRQVQQPQQYGQRRWA</sequence>
</entry>
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        <submittedName>
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        </submittedName>
    </protein>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="692275.N1QH14"/>
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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        <location>
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            <end position="383"/>
        </location>
    </feature>
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        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF11744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="460" mass="52542" checksum="7F91BC34B68F1B17" modified="2013-06-26" version="1">MTSSDLAEMGASARPPPPTRPPPRFPLQRRRHRSPGSDDRGGMWNDNSTGRRRPKRRRLDSEPSLPPKQPIKYGQHGQVEPGKLQLEIISCDGGEHRDPRYPQTYLGSDNLLRHDKSVYCSDRPSSGIVLRHADDSPFCLEKLYVCGPEHGFTAPVREGLVYVGMTLDDLKKYMDPPPHARLNGIHTPPYRNRRGTYRRPLSSERITLSDALRDPEVGAALEERDSASYAARADAAHDLANDSYYGDDSRLESEPHCELPWMREAEDPFDRPEALPVTFLSDEEPGPEESSSQEVLDFRLHRLRHMRRRLEVDNWDRDRARWAGIPREERSNDSYNLRRLDAMMARTNMAGSPDELDERDTSYSQGPEAGYGPSYYQRRPDDECPDGTEFYDDGLSDPHVTRARFHIRRGRYKVAIKFDPPVSGRFILLKLWANRGNVDVQSVIAKGYGGARFFPAVDFR</sequence>
</entry>
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    <accession>N1QHQ9</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
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        <name evidence="1" type="ORF">SEPMUDRAFT_137520</name>
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    <organism evidence="1 2">
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
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            <dbReference type="PubMed" id="23236275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="27899979"/>
    <dbReference type="eggNOG" id="ENOG502R9Z7">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_182433_1_0_1"/>
    <dbReference type="OMA" id="MCDWEEF"/>
    <dbReference type="OrthoDB" id="4966402at2759"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF16776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="68" mass="8078" checksum="792B37047BF8C771" modified="2013-06-26" version="1">MCQYEVIHFECGHSGRRLIKHCHFARNDANHHCFSAWVVKREWRSLQVCQGCGQQADVRRNQQAQLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2022-12-14" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>N1QHT6</accession>
    <name>N1QHT6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_151528</name>
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    <organism evidence="1 2">
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        <name type="common">Poplar stem canker fungus</name>
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        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016906873.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="27904010"/>
    <dbReference type="HOGENOM" id="CLU_2689385_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF09554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="74" mass="7834" checksum="D8D275C606F8BA83" modified="2013-06-26" version="1">MPAIGSHIHRQRCCLRAGQRTVVTRTISNAPRTLALDGSATSSRGDVLSVILPPSSPLYSLHPRCSGDFTASST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1QII7</accession>
    <name>N1QII7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_146150</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable lipid hydrolase.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765167.1">
        <property type="nucleotide sequence ID" value="XM_016903481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QII7"/>
    <dbReference type="STRING" id="692275.N1QII7"/>
    <dbReference type="GeneID" id="27900618"/>
    <dbReference type="eggNOG" id="KOG2214">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009031_5_0_1"/>
    <dbReference type="OMA" id="SIVPWPH"/>
    <dbReference type="OrthoDB" id="10049244at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021771">
        <property type="entry name" value="Triacylglycerol_lipase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF44">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11815">
        <property type="entry name" value="DUF3336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="6">
        <location>
            <begin position="168"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF17046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="566" mass="63665" checksum="9A41BD7845FEFC8B" modified="2013-06-26" version="1">MSDVLHAWTSHLLAWSRRKPVKAALLDKIKAAQHYDEWLEAAQALDNLPNAYRWRINPIDSRYDFRLLEERRRNLYLKRRDDDIPELTSYLRHGLFRNMYGITKLALYDKTYASTKENIHLYVDVTVDSIRTIATSATSETTRDGRLSAQELIDNVHDAKQTFGHSALMLQGGSIFGLCHLGVVKALLQEDCLPRVIVGTATGALMAALVGIHTREELPELLCGERLDLSAFAASSLEAKRRNAAELELLGKDAPAGILPNWFHVLGRRIERLAMEGFILDPDVLNECIKANVGDITFAEAYQRTGCILNIVVSPPTEDIPSLMNHLTAPNVLVRSAAMISHVTNIVYQKSRTPIYLLSKDSDGNIETIMLPPPSHETAHPAQRPGLRLAHDHPTRRLRQQFNVEHFIICQARPYLAPFIQPSLPYVRGEGHSWLPPLFMGLVKHTLQLADIFGVLPANISRILSDEQIQGDKFILVPELAITDWRRMLKNPSKEEVDYWILKGERCVWPSLCALKVRMTVENALAEAWTSVKRKKGGNCGAETNTAADERSLIALPPQPVYRADQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1QIK6</accession>
    <name>N1QIK6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_117629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759771.1">
        <property type="nucleotide sequence ID" value="XM_016901353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QIK6"/>
    <dbReference type="GeneID" id="27898490"/>
    <dbReference type="HOGENOM" id="CLU_1235714_0_0_1"/>
    <dbReference type="OrthoDB" id="3626207at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110868" evidence="1">
        <location>
            <begin position="25"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF11650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="224" mass="23605" checksum="816D7112128368B0" modified="2013-06-26" version="1">MTSFKQMAGAILAIPLFFTAQVAALPTAGVSCYDPLSLTVADRKQITGLSPQANQPLSCFDPSGTVADQGWKMWMHASAFCQEFDLAIIPVNGSITASSYQAVNGNYYNLEVANVRCDSQQVRVDDCMSLFSEILVDCNTGANDLNVGGLVSTDCGHVTLLPSVDKVDTPGSTSSNATHAVRDIYPDGCNPPVWSACSSSEKAALLDNACDFSLCLKAGNCAPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1QIZ8</accession>
    <name>N1QIZ8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_146289</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765307.1">
        <property type="nucleotide sequence ID" value="XM_016903555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QIZ8"/>
    <dbReference type="STRING" id="692275.N1QIZ8"/>
    <dbReference type="GeneID" id="27900692"/>
    <dbReference type="eggNOG" id="ENOG502SA5X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048021_0_0_1"/>
    <dbReference type="OMA" id="FIRRICV"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF22">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION FACTOR A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="330"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="330"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="117"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="174"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF17186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="411" mass="46323" checksum="2E614E15E673DA36" modified="2013-06-26" version="1">MVRRAARAPCWGRVMISSYKPVLPSLVGFISYTVTHRQLHATPNQASGNNNNNNNNNNAGSDTSQQRIQQIHAMLERMLLRFPVRSRMPLVLLHSPRDRAAAGVRAPFALALASSVKTRSYATPGRPKSVVGEPSRPVKRAVKKAANEPADGNSAPKGQVAAKKRTPTSTRALTPEKAKQQKDAAEKKDARAAALKAKAALRKSSDRKKAKLKDLKAAALPDAPRRVVYYSAYQLYWSEHVKATVDTNATTTARTKEAAMKWKELSAADLEHYNHLQRTQREASEAEYQRWIESYTPEQIRLANLARAQLRREFPSQNSKWAELQDQRRPKRPESAYLIFSRNRQASGDFTHIKVPDRSKLLSQEWKALSESERSKYEKLYNQNHERWTEEYTRAYGRAPDVKKAAAAATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJI9</accession>
    <name>N1QJI9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">biotin synthase</fullName>
            <ecNumber evidence="4">2.8.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SEPMUDRAFT_146433</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the radical SAM superfamily. Biotin synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.6" evidence="4"/>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765522.1">
        <property type="nucleotide sequence ID" value="XM_016903653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJI9"/>
    <dbReference type="STRING" id="692275.N1QJI9"/>
    <dbReference type="GeneID" id="27900790"/>
    <dbReference type="eggNOG" id="KOG2900">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033172_3_2_1"/>
    <dbReference type="OMA" id="NICTTHT"/>
    <dbReference type="OrthoDB" id="2414104at2759"/>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004076">
        <property type="term" value="F:biotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000011">
        <property type="entry name" value="Biotin synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01694">
        <property type="entry name" value="BioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010722">
        <property type="entry name" value="BATS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002684">
        <property type="entry name" value="Biotin_synth/BioAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024177">
        <property type="entry name" value="Biotin_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00433">
        <property type="entry name" value="bioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976">
        <property type="entry name" value="BIOTIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976:SF2">
        <property type="entry name" value="BIOTIN SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06968">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01060">
        <property type="entry name" value="BATS_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00272">
        <property type="entry name" value="biotin_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01278">
        <property type="entry name" value="biotin_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00876">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="16">
        <location>
            <begin position="113"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="400"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="415"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMF17401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="433" mass="46061" checksum="27EAB488993D2755" modified="2013-06-26" version="1">MSLTLLSKRAPARCLRASGAVGGGGGGGGVAAAVATAVGGTRAFSTPVNDSFAPISTTPPSAPEAQGAVWRAVNARAPRHDWTKDEIRELYNTPLMELAHQAGVLHRRFHSPSAVQMCTLMNIKTGGCSEDCSYCAQSTRYNTGLKAEKMSPVENVLQAARIAKDNGSTRFCMGAAWRDMRGRKTSLKNVKAMVEGIRAMDMEVCVTLGMIDQNQADELKSAGLTAYNHNVDTSREHYPSVITTRTYDERLQTLSHVRNAGINVCSGGILGLGEKPEDHVGLLYTVSTLPAHPESFPVNALVPIKGTPLGDDPNRTRIAFDAILRTIATARLVMPATIIRIAAGRTTMSEAEQILCFSAGANAVFTGEKMLTTDAVGWDADKVMFEKYGLLPMRPFERGGYRDATSTAPAPTPTQETLSSAETTSAGNVAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJM1</accession>
    <name>N1QJM1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_55872</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764608.1">
        <property type="nucleotide sequence ID" value="XM_016909378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJM1"/>
    <dbReference type="GeneID" id="27906515"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_22_3_1"/>
    <dbReference type="OMA" id="HKLHNNL"/>
    <dbReference type="OrthoDB" id="3437016at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF191">
        <property type="entry name" value="VACUOLAR BASIC AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="428"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="466"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="537"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="72"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF16487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="568" mass="61438" checksum="AADFA84A2BB81DD7" modified="2013-06-26" version="1">MPKRQSLQSLPPEPINETTPLLHPNQDGSNTGSLPAENISELEAQAEQERREYESGHIPLATTPSTKRLLATMSSLWTVTFFAALDTTVVATLSNPISAAFHSGTSFSWIATGYLIANAAFQPLSGKLTDIYGRRAGLIFAFTFFSAGTLICGLAQSATVMIVGRVIAGAGGGCLNTISVFVASDLIPLRRRGVWQGIGNIVFGLGMGLGGVFGGWINDTPGLGWRWAFYIQIPFAVIGGIFGSYMLDIPVRESDKSKIQRVDFLGAGTLVTALVLLLLGLNSGGNIVPWNHPLVYVSIPLSFLMLLAFIYIEDRIAAEPIIPVRLLANRSVAAACLTNWFMTMSVFSLIYYGPIFFQVVRHVSPTRAGTLFIPQAIGTSLGSLASGIVMRLTGKYWQLNILMQILALLSTSLILWQFDENVPAVSPFIFLFMEGTAYGSMLTITLIALISAVDHKYQAVITSASYAFRSTGSSIGITIAGAVFQNLLKSGLYDRFGSEAGAADRIQRIRESTDELDHLPEGWYPGVIASYVDALRGVWVVVVGFAALTAIVSGFIKQHKLYNNLDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJY6</accession>
    <name>N1QJY6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TPR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_160030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764713.1">
        <property type="nucleotide sequence ID" value="XM_016907877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJY6"/>
    <dbReference type="STRING" id="692275.N1QJY6"/>
    <dbReference type="GeneID" id="27905014"/>
    <dbReference type="eggNOG" id="KOG0550">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015935_2_1_1"/>
    <dbReference type="OMA" id="KLYMNRA"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000097">
        <property type="entry name" value="DnaJ homolog subfamily C member 7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052758">
        <property type="entry name" value="SRC_co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44200">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44200:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="77"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="111"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="262"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="308"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="346"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="6">
        <location>
            <begin position="434"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="504"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="505"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF16592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="523" mass="57281" checksum="5B85A5F9544C9559" modified="2013-06-26" version="1" fragment="single">MSSTNSPRHSREGGVPVPPDAMETTPAPETPGSFPTTNGTNGISESAEEGEHPAPAPPPHKSQPTSPPPPETRPEDAEKFKAEGNKYYKVGKYAAAIDEYGKAIEANPTSSTYLSNRAAAYMAAGKYIEALEDCKRADELDPGNAKILHRQAKIYTALGQPQEALDVYDRIQPPATAKDKQPALDMQKHLSGAQDSLKNSSSGSMVLFALDQAEKGLASTVQPPRKWRLMRGEAYLKMSTINSLGDAQNVAMSLLRQNSADPEALVLRGRALYGQGENEKAIQHFRQAISCDPDFKDAVKWLRLVQKLDKTKAEGNDHFKYGRYPQAVEVYTSALEIDPTNKGTNSKLLNNRAMCYTKLKKWQDAINDCDAALKLDPSYVKASKTRAKALGASGDWEEAVRAFKSIAEQNPEEPGIAKEVRDAELELKKSKRKDYYKILGVDKECGDTEIKKAYRKLAVIHHPDKNPDDPEAENRFKEIQEAHETLIDPQKRQRYDSGVDLMEDGGMGGGGFPGGMGGMGGMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>N1QK42</accession>
    <name>N1QK42_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_146554</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat MET30/SCONB/SCON-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765691.1">
        <property type="nucleotide sequence ID" value="XM_016903726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QK42"/>
    <dbReference type="STRING" id="692275.N1QK42"/>
    <dbReference type="GeneID" id="27900863"/>
    <dbReference type="eggNOG" id="KOG0281">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_103_4_1"/>
    <dbReference type="OMA" id="KQEWRKM"/>
    <dbReference type="OrthoDB" id="19711at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="6">
        <location>
            <begin position="367"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="475"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="558"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="598"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="638"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="720"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="137"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="223"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="319"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="326"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF17570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="843" mass="94389" checksum="6EDB7440E9BD4232" modified="2013-06-26" version="1">MQDGTSSPTPSSLLPGYTPHRPQMPTERPHTMHASPAFSFVAEQNDQEYDSVSDHGESTPRASAVEPICSRGADVQRRRMSRDDTANDMHMFAGSGDVHAVAADSEAGAVDTFGLLWGEIPPHLTEDEYRIEHARLQQLQQQQRARKGPSSGVITDAEHAESSKSSSSIGRRFSKYSKDRVNNLRESMHRYALPVSVGRARRSSTPNPIDCQDVACLNSAMQLSKQPTSPSKRSARHDIDRPRKYRNNLFPTGDRKDTPAPTTLGQGLPVRPATSSRYVPAISSAPGGDAARKAAAMHNNTLPTPSTISDWVIPEQDSDHRRHRLGSMSSAADSGADLSTYSGSDLGSTRDVDGDVTMMEYADPPTRDFTKLFPVELSYTIFEYLSHKDLLQAEQVCHKWKKLGEHASVWRTIFHRRYQRQVFTNPAPVQVGGNGIGLPNLKFPKQEWRKMYKARVELERNWRQGAGNAGKAVYLSGHTDSVYCLQFDEEKIITGSRDRTIRVWDINTYQCLKVIGGPNVRPVAGPKVLRTVDYPHFHMATASVNGTAYGDNIYHQPNQYHDASILCLQYDEKILVTGSSDSDLIVWNIHDYSFNRRLSKHTGGVLDVALDAKHIISCSKDSKIIVWDRETYEAKGELTGHRGPVNAVQLRGHLLVSASGDGIARLWDINQMKLIKEFSPKERGLAAVEFSEDMKHVLAGGNDNITYKFETETGREVMQYTGHTQLVRSLWLDSANERVVSGSYDLDLRVYDFNTGAELWRGEEWTTSWMLAAKSDYRRIVATSQDGRILIVDFGILKGAPCYQSRDGQPIENIDLLRGIERTSQIKFRDPFAQRRDTVIRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKA3</accession>
    <name>N1QKA3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_76130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764808.1">
        <property type="nucleotide sequence ID" value="XM_016910128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QKA3"/>
    <dbReference type="STRING" id="692275.N1QKA3"/>
    <dbReference type="GeneID" id="27907265"/>
    <dbReference type="eggNOG" id="ENOG502SAHR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022340_1_0_1"/>
    <dbReference type="OMA" id="WGEFIDG"/>
    <dbReference type="OrthoDB" id="5420391at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42084:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PPK6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42084">
        <property type="entry name" value="YALI0E26631P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF16687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="493" mass="53224" checksum="F6665D8F464CD6F2" modified="2013-06-26" version="1">MSGTTHRSPGLSTVSRNSTPFPPKAQTREAEPEQVIGQHPFAKHMDFLFSGGDDEYDAGDDDLEDLSKNPEAAMEYSKRIIAEQEAQAKKKPLPFSKPQGPSPLPPKASNKLQKKSGYVPAKDPNVLFDVDNVSEPDLDDDFGDFEAAPVSAPQPAPTRPATPPASAPKPRMPQIDLLGLGDAVSVPNIMSPRSERAHELLGHAKADSMSRPKSSSLLPKQEEDVWDDFDTADPVSAPALLPSHGKETSMAASRPPPSTSIASVLNSIKSEPSQSELPPTNIPPPLILLSRFTAIFSAADEALFHPLSKLESTQRGQLLAHPATHQFLATHLQSAIVLAHIIAGRKLRWKRDQILAASMRIGPSAAGGGKGGMKLTSIDKSEAGKEDREVLDTVQRWKGQVGKFRSAVAAAPGKLGPVPEVAETMPVRTLKATEGGFTAPHACALCGLKREERVVKVDVDVNDSFGEWWVEGMNLHTLCMQWWNEHKGNLKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKC6</accession>
    <name>N1QKC6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transglutaminase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_122202</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglutaminase-like superfamily. PNGase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764843.1">
        <property type="nucleotide sequence ID" value="XM_016901752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QKC6"/>
    <dbReference type="STRING" id="692275.N1QKC6"/>
    <dbReference type="GeneID" id="27898889"/>
    <dbReference type="eggNOG" id="KOG0909">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031058_1_0_1"/>
    <dbReference type="OMA" id="AWDKPRL"/>
    <dbReference type="OrthoDB" id="409136at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000011">
        <property type="entry name" value="peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.620.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050883">
        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143">
        <property type="entry name" value="PEPTIDE N-GLYCANASE PNGASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143:SF19">
        <property type="entry name" value="PEPTIDE-N(4)-(N-ACETYL-BETA-GLUCOSAMINYL)ASPARAGINE AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Transglutaminase-like" evidence="5">
        <location>
            <begin position="266"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="427"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="73"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="428"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF16722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="480" mass="54558" checksum="ADFEA2343BE76831" modified="2013-06-26" version="1">MADPSQNTHRGVPRRKPVPRPSAQPLPETWAADLTMQFRRTLSTKRMNELSRRPASMRRSSSRRTELVTVSSPAPPVPSRDAPAPPVREAPGAPQEGIQRQQSPPPEYASLRNIPNMPTPPTDPKSIRFRHMLVSLSNTPCKWENPGLLDDALAKLPLQRIYDEAQEESDLYRAEAASLGPNTKPAWGYQDCVIRAMMRWFKEDYFEWTNNPKCSTCHQPTIGRGMVAPLPEEQACSASRVELYQCSNAQCQSFERFPRYNDAFVLVDTKRGRVGEWATCFGMLCRALGSRVRWVWNAEDHIWTEVYSTHRKKWVHVDVCEGAWDAPLLYTQGWNKKLSYCIAFSADGCQDVTRRYVRNAEQAAPRAKCTEGVLLHILGEIKAMRRRDMDKQERFRLNAEDMKEDADFRKMIIEALAYNVSLILPGGEGEKSGGGGRDRTGIDPDAMKALESGQAERARQRVTSNNHHHAQQQHHQQPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKC9</accession>
    <name>N1QKC9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_129614</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764848.1">
        <property type="nucleotide sequence ID" value="XM_016902300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QKC9"/>
    <dbReference type="STRING" id="692275.N1QKC9"/>
    <dbReference type="GeneID" id="27899437"/>
    <dbReference type="eggNOG" id="ENOG502SG5B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022723_1_0_1"/>
    <dbReference type="OMA" id="TPYGMPL"/>
    <dbReference type="OrthoDB" id="5421784at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="269"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="525"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF16727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="560" mass="57396" checksum="8DFEE1C7EC5BFB0F" modified="2013-06-26" version="1">MAPPSKRRKLSSSGSSARIYRDNSTALDTLPSFSHSVQSMHGCATPDSPQLQHSPTPTDNALHHELKRDAVEGVDHFAGIAPRQDSYTELPTTMPTLGPTLGIQTFTDASTTLTYTPPALPSLPTLPSIPGATTFSSTTLTSSTLSTPSPDPYPSSNGNLSSSSSPSSSSSSSSTTTTIPGNITSSTSASSSLVSLTNVPIGNNGTIASRTAVTVTSSVSSTLYYTTLEDGNVSTITLSSGTFTTIVDGEVFTVTGNSVYSDSQAPLQSPTSTTTSDGQSTTSTSAVSGAGAPQTYGTPANTGAAGSTSTDTSNTDDNGNHNSTPPAGTIAGGVVGGAAGLAVILLIAMLFVRWYRRRSQMRHQALPPGTAGGGAEQSRSAPGMAERAGMAPFAAAIPALFRHQNPSTEPGQSERGFTRVSGRKLPSQWSEGMSSSQLPNMPQTIATSGEGSAGRNLDNTSFYRNSPAFDGGNDGDLSPSAASPESIDGGPLRTSDPGSVMMMSRGPERQPEVHHGSPLQRPGQASTLSTSPSAASALGRSETPSSMLEPNRSSRFTEDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKP4</accession>
    <name>N1QKP4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_123145</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765952.1">
        <property type="nucleotide sequence ID" value="XM_016901829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QKP4"/>
    <dbReference type="GeneID" id="27898966"/>
    <dbReference type="eggNOG" id="KOG0475">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003181_2_1_1"/>
    <dbReference type="OMA" id="ILTAKWV"/>
    <dbReference type="OrthoDB" id="44789at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03684">
        <property type="entry name" value="ClC_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF3">
        <property type="entry name" value="CLC CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7 9" id="KW-0868">Chloride</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="736"/>
            <end position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF17831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="793" mass="86693" checksum="F41EBCFF7B80AFEF" modified="2013-06-26" version="1">MESDERAPLLEASLNQNHIVRLDEDVESMVQSHLTKDEQNLYDASVGERLAYNDYTTIDWLHDLVKDSYRFRFIGERKGIRFQLIKYFDQASGWIAAALIGSLTACVAFLVDVAEATVSDWKLGYCSPNPFKTREACCANRTPLTNLPIAADDDGAGLDCVHWKPWSSSYASLFLAYLGFALAYGIISGSVTLLTKRSLPATAPGYGDRDQSSKQQPAPVAGKSMYMAAGSGIPEIKTILSGFVIPGFLDFQILAVKAIGAVFAVATGMCLGKEGPFVHIATSVGYLVAKCFHKYRDNGRKMREILSAACAAGLSVAFGAPIGGVLFAYEEISTYFPRKVLWRAFLCSLCAAMVLRALNPNGTGKLVLFETNYGTSYSPVHYLAFIFLGIVGGVFGGLFCKLNYIWSKWFRSFSIIKNHPVLEVFLVVLVTVLLQYPNPLTREPGDVIIKNLLVDCRDDDSRHTWVCQQESFENRSGYYGFLVHGTLTKLILTIVTFGIKVPSGIIIPSLDAGAFFGRLTGQLIPGISPGIFAMVGAASFLAGVSRMTVSLVVVMFELTGELEYTVPHMLAILTSKWVADSLGGKESVYDLAQNVLGHPFLDIDHSMQLVQKLPQHAIVAEILPPKQTMDEITVNVPDHSNTVSRALLVKKLHQLQARGLMDAGLVLVNQTTGILQGYLGQAELEFGLGSLSGLHNDQNMEEVRLLSSAAAAPSGEEEEEQEEQEQENIIDLSHFVDRTPLTLSAVAPMEYAVEMFGKLGLRYLMITEEGTGKIVGVVIKKRLVAYLDGIKNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKY5</accession>
    <name>N1QKY5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_153700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765981.1">
        <property type="nucleotide sequence ID" value="XM_016907521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QKY5"/>
    <dbReference type="STRING" id="692275.N1QKY5"/>
    <dbReference type="GeneID" id="27904658"/>
    <dbReference type="eggNOG" id="ENOG502THB6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1013962_0_0_1"/>
    <dbReference type="OMA" id="DWSHINL"/>
    <dbReference type="OrthoDB" id="3689744at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110953" description="Peptidase A1 domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF17860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="29717" checksum="A3286A2FFB8B0471" modified="2013-06-26" version="1" fragment="single">MAKSALALFRLCIALAVLIACAHTAVISRDLSTNLVHARSQAGTKAPAKHAAGHPTGQSTSHPKYVDIRELARGGKVIQSFPMTFKNQLPKSIPETGYIPPDEYWTERGLPVPKKNVGQTDRVQPCSATDSHLDLDDNFLSNAVTGNTHVISDTLCAPGTIGKTYSFSYSWSVNFQAGPDLKGTIISQSPVIKHVLDKIGIRGGFAYTFGQATTTSYSKSWNLPQQHPFVLTFKPNILIMSGQGREVKTNGLGAICSIGDTSHFILHVPMMEALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1QL99</accession>
    <name>N1QL99_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_146159</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765178.1">
        <property type="nucleotide sequence ID" value="XM_016903487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QL99"/>
    <dbReference type="STRING" id="692275.N1QL99"/>
    <dbReference type="GeneID" id="27900624"/>
    <dbReference type="eggNOG" id="KOG2588">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008057_1_0_1"/>
    <dbReference type="OMA" id="WVYSEQQ"/>
    <dbReference type="OrthoDB" id="2133190at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032933">
        <property type="term" value="P:SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11399">
        <property type="entry name" value="bHLHzip_scHMS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052099">
        <property type="entry name" value="Regulatory_TF_Diverse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019006">
        <property type="entry name" value="Sre1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09427">
        <property type="entry name" value="DUF2014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="238"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="954"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="967"/>
            <end position="978"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF17057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="978" mass="104823" checksum="E735D24D79C9270C" modified="2013-06-26" version="1">MDRQMPSPFGKQFNAAQNNEDWEDWLRWDPTAEPTSPDDTFHSGSSKNDSPMQESIFPLAVPGTDDASLISPLIVGDENDGLGFSSGSGSGGGGSGGGLDADFTLFGAGDIDAGFAFSQAAGLDDFPGMTKIDTTLAQWTLPANSAADPDAALSATSSSHAHGPPSSTTLAVTTPSLDQSSPSINDSRNRQSTSSTSPHPPNPAKQRGGRKRKAEAQPESNMGNENGGSQDGDDHPNKKSTSHNVIEKRYRNNLNDKIVELRNSVPSLRAMGRANHGDGNEDLGGLTPAHKLNKATVMAKATEYIKHLEKRNRTMADEMDALKEQLAKVEAAVGRSRQASVANSPLTETQRSREAPSSGPLTTPNFLNIPQDQSRFGQPVVQQQYMQLQAQPAYARPPHPPAEAQNHSQYANGRGKTFMNKMMLGTMAGIMAMEGYSEHQQSGDNTSGLASFPAVLLKRAMARPHSASSTATLSRYGFLPVVKLVMVVGILLYLLAPLLHYSPRRKHKLSASTCLPKAPSLASPVEVRRQAWLTAIQSVWVPKHFLLEVVAVGAKMFQLSLRRFVGAETFMAIAGSNKEEEAARIKAWDIAIDAQLAGGDAHVSYYRLLLTLMESGTLPDSPARLMQKAVHFRVFFWEVANAGYGNILGFKSFTEKVGRIYWDSARRQQKDLMQARSGARPAHDDDVDILPDHLARLVELDCDEVLSDDMIQRAWNLAWNKPSAHAIEANAAKDSVVEDHAIRSPIDAVAAWYANTTIDDTLADSLSDDVSSFDTEYYLGLALSVAPPASSTHVRALTAKAVLSNSNRKANIVVALEALPVLCSTGGMNLVSHAPASPDVFTALTLAKLISLTANSSPQATRERASSALNGLKLAPGQFTLLTAVAAYRLLRMLTSGNAASRAEEGVEELAGSLRVWAGTTTGRDSGLGHAGRTKIVKLCLDLAKQLGGWDDEDSGYSSADGARTPPSATCSPTRVIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1QLT6</accession>
    <name>N1QLT6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SEPMUDRAFT_146272</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">High-conductance magnesium-selective channel that mediates the influx of magnesium into the mitochondrial matrix. Essential for the splicing of mRNA group II introns in mitochondria by affecting mitochondrial magnesium concentrations, which are critical for group II intron splicing. It also suppresses a variety of mitochondrial intron mutations and its absence may disturb the assembly of mitochondrial membrane complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homopentamer. Forms homooligomers. Interacts with MFM1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Mitochondrion inner membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765293.1">
        <property type="nucleotide sequence ID" value="XM_016903545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QLT6"/>
    <dbReference type="STRING" id="692275.N1QLT6"/>
    <dbReference type="GeneID" id="27900682"/>
    <dbReference type="eggNOG" id="KOG2662">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025144_2_1_1"/>
    <dbReference type="OMA" id="NERIKMA"/>
    <dbReference type="OrthoDB" id="10251508at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045016">
        <property type="term" value="P:mitochondrial magnesium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12823">
        <property type="entry name" value="Mrs2_Mfm1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000005">
        <property type="entry name" value="Inner membrane magnesium transporter MRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.128.330:FF:000002">
        <property type="entry name" value="Inner membrane magnesium transporter mrs2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039204">
        <property type="entry name" value="MRS2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890:SF0">
        <property type="entry name" value="MAGNESIUM TRANSPORTER MRS2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890">
        <property type="entry name" value="RNA SPLICING PROTEIN MRS2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22099">
        <property type="entry name" value="MRS2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 14" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="60"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="481"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU366042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMF17172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="542" mass="60402" checksum="37C2E5962CDBEA20" modified="2013-06-26" version="1">MINPHGPIVPSSACLRFLRSVLEGPAVYANTTPSTPGCRRRLRYLSSTPAPPWTLALTSTTRTRPRQCSPPTAISSQAPAAHGSTARAHARALHSQPCLRQETFWRRLRQSRSASKPAANDHLPPLAGFLDDNAGLGGRIIKPSNELKLRCTEFDENGNVTLVNGEFRKSELIQKYSLLPRDLRKIDSSVLPHILVRPSAILINLLHLRCLIKHNRVLVFDVYGSTDSYAQSLFMYDLEGKLRQRQTTSTAGNLPYEFRALEAVLISVTGGLESEFETVREPVVRVLRELEEDIDRDKLRHLLIYSKKLGTFEQKARLVRDAIDDLLEADDDLAAMYLTEKAAGTERADDNHEEVELLLESYHKVADEIVQVSSNIVSAIRNTEEIVRAILDANRNSLMLLDLKFSIGTLGISAGMFIAALYGMNLENFIEESNLGFFGVTAASTMLSIAACWWGLKKLRKVQRLSMWGEGKRRNLRSSRGRWSEVDAAADPSTGKPLAGDVAGIKKAEGPRLWQSAQHEHDRTMHGHTKSSNRSLALRMPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1QM60</accession>
    <name>N1QM60_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydantoin racemase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_146404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HyuE racemase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765483.1">
        <property type="nucleotide sequence ID" value="XM_016903633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QM60"/>
    <dbReference type="STRING" id="692275.N1QM60"/>
    <dbReference type="GeneID" id="27900770"/>
    <dbReference type="eggNOG" id="ENOG502RZ0H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053002_1_1_1"/>
    <dbReference type="OMA" id="CAGMSGM"/>
    <dbReference type="OrthoDB" id="412018at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047661">
        <property type="term" value="F:amino-acid racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052186">
        <property type="entry name" value="Hydantoin_racemase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053714">
        <property type="entry name" value="Iso_Racemase_Enz_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28047">
        <property type="entry name" value="PROTEIN DCG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28047:SF5">
        <property type="entry name" value="PROTEIN DCG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF17362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="26804" checksum="9F2E63DBCC346E74" modified="2013-06-26" version="1">MTDALVPLVNSLGFDTTHFEFFTAPDGVPSINNEEDAAKSAQACLPVLTTQLKNYDAFLVCCYSHHPLVSQLRQALEEEEEEKEGNPLLPKNKPVTGIFEASIATCIQSINMSHKFGIVSTGSQWEQILSEAVSTILGSSDSSNETSSPYSTTRYAGCQTTGLNADELHTTPPAEVRLRMKNATKKLLRNGNAGGGGAVKAIALGCAGMAGMDAIVREACVEELGEREGRGVKIVDGVVAGVVFLEGALRSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1QM66</accession>
    <name>N1QM66_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_146417</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765493.1">
        <property type="nucleotide sequence ID" value="XM_016903640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QM66"/>
    <dbReference type="STRING" id="692275.N1QM66"/>
    <dbReference type="GeneID" id="27900777"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_1"/>
    <dbReference type="OMA" id="TWHAWQK"/>
    <dbReference type="OrthoDB" id="294295at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005559">
        <property type="entry name" value="PRK07231.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G02870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639:SF5">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_6G09140)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF17372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="248" mass="26558" checksum="62A303B2CB98330A" modified="2013-06-26" version="1">MPGRLEGKVAIVTGGGGGFGKGIAQKFLQEGAKVIIADFVEDIGQKTADELKCDFHRTDVTSKADWEALRDFCHKKYGKIDCVINNAGWTYRNKSTNEVIDEEFDKVFAVNVKAIFHSTSVLVPYLQKQGTGGSFVTTASTAGIRPRGGLTWYNASKAAVINASKSMAVEYAKDNIRFNTVCPVVGLGTGLTDSFLGKPENQATFMATIPLGRGSTPRDVANTCAFLVSDEADFLTGIDVPVDGGRCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>N1QMY1</accession>
    <name>N1QMY1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="16">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">SEPMUDRAFT_146055</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 16">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Membrane</location>
            <topology evidence="1 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="16"/>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765050.1">
        <property type="nucleotide sequence ID" value="XM_016903426.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.N1QMY1"/>
    <dbReference type="GeneID" id="27900563"/>
    <dbReference type="eggNOG" id="KOG0206">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000846_5_2_1"/>
    <dbReference type="OMA" id="YVYGQRN"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006892">
        <property type="term" value="P:post-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000014">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF174">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE DNF3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 15 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 14 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1129"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1179"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1207"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1238"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1288"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="18">
        <location>
            <begin position="97"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="19">
        <location>
            <begin position="1065"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="567"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="571"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="13">
        <location>
            <position position="505"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="505"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="505"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="506"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="507"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="507"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="650"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="695"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="718"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="848"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="928"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="929"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="930"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="1013"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="1019"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="1039"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
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        <location>
            <position position="1042"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="1043"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <location>
            <position position="1043"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EMF16929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1394" mass="157836" checksum="C50FC54C876A3120" modified="2013-06-26" version="1">MLTTTTTTPITVIAKTAAVGDPTCSTDKMGIMDSNHSSAATRCNNWYQRSVRKPAELYYQRYIVELVLRRKPLPVSKDGRHVSCRATHEQPLIDERRGHAYLSNTIRSSRYTIYDFLPKQIFFQATRLHNFYFICIGIPQAIPGLSTTGNYTTILPLTFFILLTVLKEGYDDWGRHRMDNVENNKLSRVLRLKQHSSPQQEVRKSLARTVLERSVLRWAGKIEPDMTLENEPDEDDELTWDCATKWHDIKVGDVLKLKRDEPIPADIVLLYSTGENGIAFVETMALDGETTLKTKQAPPDLLKRCSTLTELKNLQAELHVEDPNKDLYDFNGKLAIEGKTLPLTLNEVVMRGSVLRNTGHIYGIVINTGEECKIRMNANHHAPAKVPRLEKYANQIVLTLIFYVVVLSVGVSGGYLIWHHNFEKGAWYLHDAAPEFKQIIIGYLIMFNNVIPLALYVSLEIVKIGQRLMVQSDVGMFDEASGTPMSCNTNTILEDLGQISYILSDKTGTLTENVMNFQFLSCGGIVWAHDKDAVVSSTKTEQPGLKASSTAHPGKVDADKIVVETREVGEGSSSHTHLPRKSQTLSRKSMQHHRPAERTIAELLGLIRRDPHSPMARRGREFILGMALCHTALPEVKKDGIDFQASSPDEVALVRAAKEMGFIVVNRTSQKIELLVQSGHKETREVYEILEVIEFSSKRKRMSIVVRCPDGRVWLICKGADSAIIPRLRQSQLAARKSAEVRRSMDASRQLLRKSMQECRNSFGGRPSLHERGRSSMDVRHSMTIDRARSTELRPIFAQGRATLELPTISLDPGSLRDDVRALEHADDAVLFSKCFQHMDDFASEGLRTLLYSHNYVEPEEYLSWSKLYREATTSLVNRQERIEDAAEIIEQGMGLLGCTAIEDRLQDGVPETIDRLQRANIRIWMLTGDKRETAINIAHSARICRPASLIHILDSTKGDLQGQMSDIVYDGDSHSVAVIDGHTLSVIDTDPQLRLLFFTTLIANVDSVIVCRASPAQKADIVVAIRARLPGLTLAIGDGANDIAMIQAAHVGIGISGKEGLQAARVADFSIAQFRFLQRLLLVHGRYQYIRTARFILLTFWKEMYFYFMQALFQKQDGFTGTSLYEQWSLTVLNTLFTSLCVIVPGIFEKDLHENTLLAVPELYSFGQRNKGLNLRMYFAWIVHAAAQGILVWYICWKFYGPANVMGDTGLFALGNLCFSLGIIWTNWKCLFIETHYKTLIVAGSLAITVGGWWAWNGFMSHIYGNNLSPYDVRGGFHEVFGRDPNWWLTLLLAFGVLCTMEWAYAAAKRNLVVARCWPPWKFTRWHRNRNGNAEDLELELWQEMEKDAMIQKQLGRMARDEDDAEEDTLELMIDESEVWSSDKKPKKRLWLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>N1QN75</accession>
    <name>N1QN75_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">SB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_146175</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765200.1">
        <property type="nucleotide sequence ID" value="XM_016903500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QN75"/>
    <dbReference type="STRING" id="692275.N1QN75"/>
    <dbReference type="GeneID" id="27900637"/>
    <dbReference type="eggNOG" id="KOG2391">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017548_2_1_1"/>
    <dbReference type="OMA" id="YMNFPQP"/>
    <dbReference type="OrthoDB" id="306304at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072666">
        <property type="term" value="P:establishment of protein localization to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11685">
        <property type="entry name" value="UEV_TSG101-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052070">
        <property type="entry name" value="ESCRT-I_UEV_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017916">
        <property type="entry name" value="SB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008883">
        <property type="entry name" value="UEV_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306:SF3">
        <property type="entry name" value="TUMOR SUPPRESSOR PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306">
        <property type="entry name" value="TUMOR SUSCEPTIBILITY GENE 101 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09454">
        <property type="entry name" value="Vps23_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51312">
        <property type="entry name" value="SB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51322">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="UEV" evidence="11">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="SB" evidence="10">
        <location>
            <begin position="403"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="55"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="217"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="338"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="246"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF17079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="469" mass="51455" checksum="33D0E9FE450CCF8B" modified="2013-06-26" version="1">MAVRPGQHVGVDGRVYHPYLRDWAKVWDRASLAEFLGYLQHIFGKEPPVVSRAQEMAQERNHQAGPGAPPPPPPKQPAASVAAPSRSASLNSPPPIPPKPGAGAGVAPAPGEEYAETPQALRDVYRDGPPLPPLPHEMARNQRVSSLSSNRYPPASINPSLPYAASPSGYQHGHQISPPFPQGQHRQHQLYQVTRDNSPVSPISPPQGVSELPANRYAQQAPPPRPTYYGTAQSVHDPTPHHGSHAHQAQVQHQPYAQQHYGQQQQPQQQTQPKHFAPDLLTDPFEVAMPTIAAQQNIPAPPIPPNPEKEQLFEALSSILVQQARSKIGQSLAFIPPLQAQQQAIQTMQQRLDGEIRQLEHLEQALANNESILHQSIQACDRTINTAMSKKQPPIDEVLVAPTMVANQLWTLCAEEAACREAMYVLQKANDRGRVTGDVFIRQMRALGRECFTKMALSRKIATGMGLIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNJ6</accession>
    <name>N1QNJ6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_146392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765465.1">
        <property type="nucleotide sequence ID" value="XM_016903626.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.N1QNJ6"/>
    <dbReference type="GeneID" id="27900763"/>
    <dbReference type="eggNOG" id="ENOG502QVZH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002714_1_0_1"/>
    <dbReference type="OMA" id="QVGRIPQ"/>
    <dbReference type="OrthoDB" id="5382952at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="605"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="793"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="868"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="959"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1040"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1302"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="265"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="511"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="622"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="632"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="797"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1056"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1070"/>
            <end position="1082"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF17344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1419" mass="154780" checksum="CB0D40785B519DA5" modified="2013-06-26" version="1">MSLSRVLSKELTREPSRQHHSSIPTKSTTESGRPTHGTQHVAKPAKKTSRSGAQVACKNTSRARTPASESSDRNGLETHRSVTPAPPSQRTPSLVSGSSASTFDSPRSNALRRKKSGAIGKYAVQKRLETENLEYSMPTAHPLDVLDRRDVDDSIFGIFPPSTSQQAFGTHAHESSQHRNFPGEHTTSVLAQGPSSTPSTTYTDSPFSHVPTPSSASSYSSAFAAVAGATRSPQLHCSNQSGLYLRHQEQSDEGTRSSPQAVRESSTSSSSTLRTSGHAESISTQRSKGYSSSQTSVNPAKAAPRNKLTKEPSTSSSRKRTIQIPPELAHLNVDLPKVPTRPSRDGISNISDMTGPSAVVQSDLPRLYTTYHKRTSSVSVETHGSDGSPKVTKRFGFPSRSSSRHASPRVDSVTSPLPTAVRSNTRSSSESIAAQAHNTSQVQREDSPAVESVCSPSKSSRCAFFSRRPKHGTKEMKKLTKKPERTPAKGPVAGTGHEGYGRFGIRGRTASNTSSISSRSPSSDSSISVGISPTTMGRAQGKGKHAVELDDFLKTRLAPVVLRGNGIKSGQADSMSDVPGVSREPISSKNLSPCLLPSAMETSEQHCARGGPSFGRRNTFESSDDDYDDDVQTQIPSRPSRWAPTNFSQESLRSDTDDVLPVQLKSENQYPSIRPSHRKESTSPAVPNTIRHEEQVYLQPLRGSLSPTSSGKRNFLQRVTASPRTQGKDGGDLQSRAVAKKGSPMPIGHYAIAADVEPVDLAEVESLVHDVSTTPPVHEAMSAANCRTLDPPCRSVSTREQHSNDSPRRLRLSPVGRIPPVVSKRDRDRKLSEHSFSRPFVRSQPRPTVKPPGSVYTQIRDMASAVEGGGCHEVSSSDTWLDSNAPGPQNAVVHTSREAGILRMNDERGGTQSDEFITFPDRKDSQQDDIWNEYDEFMDAVARPLDAPHSPYVDLLYDGQRSQYMPPPPTGLPPKTELPAPPGSVSQQVSRFLRPSLSPMTPDTISAWISGYENRSTGTSMNGASLFELQRDSASWQRRSSLASFRDGRGSQHSRSASSPDASAPAQDAQGERYPDDDGHETYLAHMAPDRVHGRKLSNRMRHAALMTSKWLSFGRVLFSPANNELRFTSEARVLVIDGLSSDWSYYIARTYQAAEVYDMSIGPRRVSVLASGEADEPRNYRRIPITSMSTAFPFPRGFFNAVVLRFPLATTEESYFHCVSECKRVLRPGGHLEVAVLDLDLVNMGSRTRKAVKGLKTRMQIHDPSICLGNLSDVLMRMVGQNGFEGVRRCVVGVPAAGRMRSQDLSSSDSDPLVGPRGQNESVPVSRKAVDLLSPLNGNPDGLGDFGNESDEGITTMIAKVGRWWYSSCYETALPPSDHSIWRERGLLHECEVQRTSFRLLICCAQKPRQIRRRTVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNK3</accession>
    <name>N1QNK3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA ligase</fullName>
            <ecNumber evidence="1">6.5.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_146764</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + (ribonucleotide)n-3'-hydroxyl + 5'-phospho-(ribonucleotide)m = (ribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRL1 family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.3" evidence="1"/>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765954.1">
        <property type="nucleotide sequence ID" value="XM_016903850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNK3"/>
    <dbReference type="STRING" id="692275.N1QNK3"/>
    <dbReference type="GeneID" id="27900987"/>
    <dbReference type="eggNOG" id="ENOG502QQB9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010316_1_0_1"/>
    <dbReference type="OMA" id="FQDWDYK"/>
    <dbReference type="OrthoDB" id="276239at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051730">
        <property type="term" value="F:GTP-dependent polyribonucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003972">
        <property type="term" value="F:RNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001690">
        <property type="entry name" value="tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019039">
        <property type="entry name" value="T4-Rnl1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012387">
        <property type="entry name" value="Trl1_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015966">
        <property type="entry name" value="tRNA_lig_kin_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015965">
        <property type="entry name" value="tRNA_lig_PDEase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32004">
        <property type="entry name" value="TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32004:SF1">
        <property type="entry name" value="TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09511">
        <property type="entry name" value="RNA_lig_T4_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08302">
        <property type="entry name" value="tRNA_lig_CPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08303">
        <property type="entry name" value="tRNA_lig_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019634">
        <property type="entry name" value="tRNA_lig_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="T4 RNA ligase 1-like N-terminal" evidence="6">
        <location>
            <begin position="71"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA ligase kinase" evidence="5">
        <location>
            <begin position="395"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA ligase phosphodiesterase" evidence="4">
        <location>
            <begin position="556"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="609"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="616"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="active site" description="N6-AMP-lysine intermediate" evidence="2">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR019634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR019634-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF17833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="819" mass="92349" checksum="D7CB5887BD4059B4" modified="2013-06-26" version="1">MAIYEGAPYRPQDPNEIEEMLRGFEANKGKAKKSSGFSCKKATFAVNGTDIRVDSWRMQDWDYKKPNLPSYARGLFTTRTRNGHPEIAVRGYDKFFNHGEVPETEWKNVTANTRGPYELSVKENGCIIFIAGLEDGTLIVCSKHSTGDRTDVGASHASVGEQWVEKHLARVGKTRQQLALQLRSMNATAVAELCDDDFEEHVLAYSPEAAGLYLHGINLNLPEFATYPHHLVDRFADEWGFKKTTYLTNNNIEDVKSFLDRIAETGNFQGRDTEGFVIRCQSKANTGEWHDWFFKYKFEEPYLMYRQWRECTKAVIAQREPKYKKHKEITAEYITFARKQLHGNPALGKAYQQNHGIIKMRDDFLAQRGLTGAEIIRLEAQQGQVTNDAVTGDVVLVPVATIGCGKTTIALALCKLFGWGHIQNDNITVRRGKPLAFANACCAELEKYDAMIADRNNHQRRERQQLIEDVSKVVPNARFVALHFVHDRGNYDHIRQALRYRVLSRGDNHQTIHTSKGTDEIVGIMEGFLHRFEAVNSDAPPDDGFDLVINLDPTLDSRENLDTVITKLYAEYPQLFHDREMPSPDDMDSAIQWALSDYTVDIKHEIQGFDNKKSKGNNAPKSQPQSNGQPKEKKVEYFAVQVPAGRLVPILNAMFAGASPELSQMYNALRSQRRVQNEFHVTLIHRATAAEHQGTWARLTELHQKAAAPTEGRAYAIPDPNVGLCRVRLERLVWNSRVMAFVVTLVPFEGSHENFQSVNAIAHITIGTASSDIKPKEANDLLASWNWSRSQGINAAGTYEMAVPGNIELEGTVKAVLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNT3</accession>
    <name>N1QNT3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7704 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_146553</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765690.1">
        <property type="nucleotide sequence ID" value="XM_016903725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNT3"/>
    <dbReference type="GeneID" id="27900862"/>
    <dbReference type="eggNOG" id="ENOG502S3HU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112091_0_0_1"/>
    <dbReference type="OMA" id="AFFTHFR"/>
    <dbReference type="OrthoDB" id="5313995at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056121">
        <property type="entry name" value="DUF7704"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37019">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37019:SF1">
        <property type="entry name" value="EXPERA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24803">
        <property type="entry name" value="DUF7704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7704" evidence="2">
        <location>
            <begin position="11"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF17569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="149" mass="16776" checksum="9FDE4A29CFC583B2" modified="2013-06-26" version="1">MTPRNPSVQPLPLPYTLFFLWIEPISTLVGAYFAHFQQQKYLDDTIPSGLGVSTRESIVLSQLANLYFAFTLNEALVLRATRDRRVWSTLLLGLLIADFGHIYACKAAGVELYYSFWTWNAMWAGNLGFVYMGATLRTCFLLGVGLPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2023-05-03" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNW1</accession>
    <name>N1QNW1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_146682</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765830.1">
        <property type="nucleotide sequence ID" value="XM_016903795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNW1"/>
    <dbReference type="GeneID" id="27900932"/>
    <dbReference type="HOGENOM" id="CLU_2591317_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF17709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="80" mass="9049" checksum="5514B1E2252B37CD" modified="2013-06-26" version="1">MQGFEISEGIPASSHIEIVRMAATMCGFMAITYLLGQDCFAKIFCHGSSGVRCIRRSKLRFSEEVLCYQVELDLPTVLWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M3ASL9</accession>
    <name>M3ASL9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DnaJ-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_74195</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756615.1">
        <property type="nucleotide sequence ID" value="XM_016910055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3ASL9"/>
    <dbReference type="STRING" id="692275.M3ASL9"/>
    <dbReference type="GeneID" id="27907192"/>
    <dbReference type="eggNOG" id="KOG0714">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043579_1_0_1"/>
    <dbReference type="OMA" id="ARSREHN"/>
    <dbReference type="OrthoDB" id="1507364at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000069">
        <property type="entry name" value="ER associated DnaJ chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051100">
        <property type="entry name" value="DnaJ_subfamily_B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015399">
        <property type="entry name" value="DUF1977_DnaJ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908:SF3">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09320">
        <property type="entry name" value="DUF1977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="38"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="96"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF08494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="346" mass="38138" checksum="66E42C9DE5378F8F" modified="2013-05-01" version="1">MSEKKSDHHTHNDGSSSRAYTVEQKAAVIRVKRCGPTDFYEILSVERSATDSEIKKAYRKLSLLTHPDKNGYPGADEAFKMVSRAFQILSDSEKKTKYDRFGGDPESRMGGGSAASSGASPFSGGGFAQQRRGPMFEEEISPEELFRQFFGGGGGFGGGGFGGPGFMFNVGGGGPGIRVHQFGGNRPRRRPHNHDGAEQQPASVMQAFQGLLPLLLLFILPLLSSVFSGSGTPAGPQMRFDAAVPPHTQLHTSGSLKVPYWVNPNEVKDYTVKKWKDLDKKAEGKYIGHLSAECEWEQNQRNRLANEAMGFFWTDHEALERAKKMEMPSCRKLQGYGYRLPSSSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M3AVY8</accession>
    <name>M3AVY8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_119967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758372.1">
        <property type="nucleotide sequence ID" value="XM_016901559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AVY8"/>
    <dbReference type="GeneID" id="27898696"/>
    <dbReference type="HOGENOM" id="CLU_934363_0_0_1"/>
    <dbReference type="OrthoDB" id="4239773at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF10251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="298" mass="32800" checksum="3B3F3EBF43CA4492" modified="2013-05-01" version="1">MSETAVIVPGAECSDDEILGVAEQHTPNLEATIAFAEAAAAVAPALDRRILKRYDIHQPSPDAAVKEVHLNGLQPYQITRRLPRPDRPMNTISALPSGEVMAGTKAGRRESHIFVGNPSQGTTVWLPVVASDGAWNFNAIDRALRWRRMSATTTTTTKDTHEQHIPTDLELIDATTSEPLVEYHATETGAALYICSELEESCELLVLASILAITEPQRRAQKDIIRPESLVDPFLSHSSLPSSPETSPNPSPKRPCPFEHDVILSRDSVLTDKLAEFARKLSETSEEEWTARAVHHHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M3AWC1</accession>
    <name>M3AWC1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tripeptidyl-peptidase II</fullName>
            <ecNumber evidence="4">3.4.14.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SEPMUDRAFT_88216</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal tripeptide from a polypeptide.</text>
            <dbReference type="EC" id="3.4.14.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="15">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.14.10" evidence="4"/>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759161.1">
        <property type="nucleotide sequence ID" value="XM_016910467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AWC1"/>
    <dbReference type="STRING" id="692275.M3AWC1"/>
    <dbReference type="GeneID" id="27907604"/>
    <dbReference type="eggNOG" id="ENOG502QR6D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013783_3_0_1"/>
    <dbReference type="OMA" id="SGWGTPW"/>
    <dbReference type="OrthoDB" id="409122at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000015">
        <property type="entry name" value="Tripeptidyl peptidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF39">
        <property type="entry name" value="PEPTIDASE S53 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 15" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8 16" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0843">Virulence</keyword>
    <keyword evidence="13" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004031511" description="tripeptidyl-peptidase II" evidence="16">
        <location>
            <begin position="19"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="17">
        <location>
            <begin position="231"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="316"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="530"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="572"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="573"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="591"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="593"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMF11040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="621" mass="67344" checksum="CAA7C4A1D8449580" modified="2013-05-01" version="1">MLFTSIVCAFGTISAAYALPKSPRSSYAVKEYHPVPRGWTRVGEAGKSDRVHLTIGLKQQNQGAIEEHLLQVSDPSHARYGQHLTAAEIADIVRPSQETQDLVKSWLEEHGIQGVHNAAKDTIHVLVPIEKAEELLQTSYSVFEHEDGSTLARAPEWSLPRHLHEHIDVVQPTNSFFRTKATSHGATSLQRDTIQYSDSWWQNEGKKAFAPPPAYRGSGAGPISEICNISFTTPDCKRTLYGTYDYKPQVPGKNKMGHTNYLNETSYRQDIKKALQNFRPEAVSAADSFNITTVADGNNDQGPYTDAQVRAGKNEEAVLDSENMISIAYPTPLEVWQTGGSPPFIPDINTPTDTNEPYLVWLDSILDRDDLPQVISTSYGDDEQTVPQSYAERACSSFAQLGARGISLFFSSGDSGVGSDGTCFSNDGKKTEMFLPSFPASCPWVTTVGGTQGFEPEVAVQRFASGGGFSNYFPAPEYQNATVQAYIDSLKGLHDGLYNKTGRGYPDISAQSNRDAIVWNGDIITIGGTSASSPTVAAIISLVNDALLAEGKPTLGFLNPWLYSGAYKALTDVLSGSSFGCDTDGFPAQAGWDAVTGFGTPNFPKLVDAALAKSEEKPTGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M3AWI0</accession>
    <name>M3AWI0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thiamin biosynthesis protein (Thi-4)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_142598</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759226.1">
        <property type="nucleotide sequence ID" value="XM_016903007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AWI0"/>
    <dbReference type="STRING" id="692275.M3AWI0"/>
    <dbReference type="GeneID" id="27900144"/>
    <dbReference type="eggNOG" id="KOG2598">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020520_2_1_1"/>
    <dbReference type="OMA" id="FWEMFPY"/>
    <dbReference type="OrthoDB" id="10028886at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008902">
        <property type="term" value="F:hydroxymethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008972">
        <property type="term" value="F:phosphomethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01169">
        <property type="entry name" value="HMPP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19367">
        <property type="entry name" value="TenA_C_ScTHI20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.910.10:FF:000003">
        <property type="entry name" value="Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000034">
        <property type="entry name" value="Putative hydroxymethylpyrimidine/ phosphomethylpyrimidine kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004399">
        <property type="entry name" value="HMP/HMP-P_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004305">
        <property type="entry name" value="Thiaminase-2/PQQC"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00097">
        <property type="entry name" value="HMP-P_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858:SF17">
        <property type="entry name" value="HYDROXYMETHYLPYRIMIDINE_PHOSPHOMETHYLPYRIMIDINE KINASE THI20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858">
        <property type="entry name" value="PHOSPHOMETHYLPYRIMIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03070">
        <property type="entry name" value="TENA_THI-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine kinase/Phosphomethylpyrimidine kinase" evidence="3">
        <location>
            <begin position="11"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Thiaminase-2/PQQC" evidence="2">
        <location>
            <begin position="303"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF11105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="524" mass="57620" checksum="6F3A7F8419E6AEDC" modified="2013-05-01" version="1">MRRVLVVAGSDSSGGAGLEADQKVIAAHGCYAMTATTALTAQNTQGVYGIHETPPSFVQQQIDACLDDIGVDVLKTGMLASAQTVAVVANAIQQHNIPITVVDPVMVSTSGAQLLPEKAVTNMITELLPLTTVLTPNIPEATLILRKAGKEPFPIDNLEGLKRLAAEVHTLGPKYVLLKGGHFPLTYAYQTANSELDKKLVCNILCGGTDKVMDIIEFPYQKTKHTHGTGCSLASALACNLAQGLEMTPAVVAACRYIDAGIKTAFKLGNASGSGPINHFHSVQILPFPPGGFVDYLLGRSDVVACWYKFTHHEFVERLGEGTLEVERFRHYMIQDYLYLVHFARANALAAYKAKNMEEIAASAEMVGHISQEMRLHVRECEEGFGLKEEDLRKKQESLACTAYTRFVLDIGASEDLLALQIALLPCLLGYAEIARRLLKKQQQQQQQQQPPQQQAQRQQQQQNGKSKKGHGSNRYQSWIDNYVSDDYTRAVKTGCDLVEKHAHKQSPQRIEELTKIFIHATRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M3AYM7</accession>
    <name>M3AYM7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_44038</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760778.1">
        <property type="nucleotide sequence ID" value="XM_016908915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AYM7"/>
    <dbReference type="STRING" id="692275.M3AYM7"/>
    <dbReference type="GeneID" id="27906052"/>
    <dbReference type="eggNOG" id="ENOG502SB01">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014049_0_0_1"/>
    <dbReference type="OMA" id="HSWSPIF"/>
    <dbReference type="OrthoDB" id="610608at2759"/>
    <dbReference type="UniPathway" id="UPA00771">
        <property type="reaction ID" value="UER00766"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003885">
        <property type="term" value="F:D-arabinono-1,4-lactone oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007173">
        <property type="entry name" value="ALO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010031">
        <property type="entry name" value="FAD_lactone_oxidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762:SF1">
        <property type="entry name" value="D-ARABINONO-1,4-LACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762">
        <property type="entry name" value="L-GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04030">
        <property type="entry name" value="ALO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="2">
        <location>
            <begin position="15"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF12657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="558" mass="63723" checksum="656434095A816E88" modified="2013-05-01" version="1">MTIKENLEFQNWGRTHSNTPKYTVVPRNVADIQKVVRFAKQANLGVRCAGYRHSWSPIFGRTGEIMISTLDIKTASELPDITALHLPQEKPNELETIELLPGPARAAGKHLVRIGCATTNERLRRWCVKHNKVTIPLNIIMVEITSGGSNGPICHGAGIKHQTLSDLVRKIEYVDANGELQSITDEDPELLTAASGAFGLMGVITHLTLEFDTMTYAELRPTKMPVIQTIPPPPGFPEDRIPRALRPKTPLTAAEKQFAQERFEKQANEDYYAEWFWFPYADECWVNCWNNTTDDSDVEDWPGSFAVFLSFVQEFTLNVIQYNHVLTELVNKTGIAEAAVTLLSRFVMMNLPEVKEGDKAIKTHLINGLHFQRAIQNIRVRDMEVEIPLVPRVDDATKVDYTLVQQAWWDAIVKCYEHSDTCPQRFPLELRIMGGSNVLLAPQYGNRLGTAAMEILTLQNAVDIWQPYAQEVVDLWCSYKDRNGVRLKTRPHWAKEWHEGYTIDGKPWLEKLKHEDYAAEIVEFKRILSRIGKKHGWTLEDIQKRFSNELFDGLIYDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M3AYS9</accession>
    <name>M3AYS9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_149298</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760828.1">
        <property type="nucleotide sequence ID" value="XM_016905472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AYS9"/>
    <dbReference type="GeneID" id="27902609"/>
    <dbReference type="eggNOG" id="ENOG502S37A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_3_1_1"/>
    <dbReference type="OMA" id="YGVQKLG"/>
    <dbReference type="OrthoDB" id="630895at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051531">
        <property type="entry name" value="N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792">
        <property type="entry name" value="GNAT FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00765)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792:SF16">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="35"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF12707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="230" mass="25275" checksum="D6DCA4B2F84E2D80" modified="2013-05-01" version="1">MLQKSTTASESPSHERRSQREDEMTESKFRIETERLVLTHLQPSVSSHCDFMVKLWNTKEFIASTGGKPTSITTTEAARKLIENRFQAEYARNGYGTYLVSLKSPPGNESSEAIPPPPSEEEPIGTVSLTRGAHPTAYSAPDLGFAILPDYMRKGYAREAATGLLAWAESELHVYDVLGLCDPTNEGSNGVFRSLGFVDRGVRTLKEFGNVQGAVWVKPGMAEDLSVYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M3B734</accession>
    <name>M3B734_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_60711</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763768.1">
        <property type="nucleotide sequence ID" value="XM_016909537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B734"/>
    <dbReference type="GeneID" id="27906674"/>
    <dbReference type="eggNOG" id="ENOG502QPXG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027163_0_0_1"/>
    <dbReference type="OMA" id="MPIADHQ"/>
    <dbReference type="OrthoDB" id="2589563at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037737">
        <property type="entry name" value="Srf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36819">
        <property type="entry name" value="REGULATOR OF PHOSPHOLIPASE D SRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36819:SF1">
        <property type="entry name" value="REGULATOR OF PHOSPHOLIPASE D SRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="271"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="333"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF15647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="364" mass="41111" checksum="1D5E74E7E682A6D2" modified="2013-05-01" version="1">MPEMQQRSALLIPSQPQQRRLPDTSASHASSSTAADSDPHQANSLPPWIHVNDEAAPFLEPAPILPNTRHYKVPPKYQPGRKLDAYRDAEPGLLSAPIADHQVRWIPFMQSGPNPREQRDQRIVRSDSWMRENVPIFNRAWQEEDEMMPESKRHRGLPGLLFRGKWLISPERQERSVRLFWRLLLKNAFVPLGFRVFVLSFSCAALGVAGTILKSVNSVNRDNDAFNQCAPRASTYMGIIVPAVAIPYIGYVTWDEYTSKPLGLRSVAAKVLLLLCDLYFIVFSASNLSLAFSALFDGSWACFETGQMLIGQQYIDIPKTCPNNPNICYKQKALSGVLLITLLAWLLCFSVSVLRVVEKLRLEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M3B7C6</accession>
    <name>M3B7C6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutathione S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_80857</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763888.1">
        <property type="nucleotide sequence ID" value="XM_016910259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B7C6"/>
    <dbReference type="STRING" id="692275.M3B7C6"/>
    <dbReference type="GeneID" id="27907396"/>
    <dbReference type="eggNOG" id="KOG0867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011226_14_2_1"/>
    <dbReference type="OMA" id="ATQYAKH"/>
    <dbReference type="OrthoDB" id="10005898at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03048">
        <property type="entry name" value="GST_N_Ure2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF3">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR URE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="3"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="91"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF15767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="224" mass="25967" checksum="B77C9C32F78EC7F5" modified="2013-05-01" version="1">MTKPLKLYGHVQGPNPWKVAIILEELGVPYHQEFLDFSVLKQEPFISANPNGRLPALEDPNTSITLFESGAIIDYLLDTYDPNHTLRPTSPPTTKYLQISWRDFQMSGQGPYFGQKAWFTHFHSDLHMTSAIERYSNEIRRILGVIDAHLKKTNQPYLVGKQVSYADLMFVPWNSMLGFLMGEEFVEEGWKREFPVCWEWHRRLVERPAVKKVLEEKAVKMAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M3B861</accession>
    <name>M3B861_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Calcineurin subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Calcineurin regulatory subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Protein phosphatase 2B regulatory subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_147723</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Composed of a catalytic subunit (A) and a regulatory subunit (B).</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the calcineurin regulatory subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF16027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764148.1">
        <property type="nucleotide sequence ID" value="XM_016904484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B861"/>
    <dbReference type="STRING" id="692275.M3B861"/>
    <dbReference type="GeneID" id="27901621"/>
    <dbReference type="eggNOG" id="KOG0034">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061288_10_1_1"/>
    <dbReference type="OMA" id="DTNFDRD"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005955">
        <property type="term" value="C:calcineurin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004723">
        <property type="term" value="F:calcium-dependent protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071444">
        <property type="term" value="P:cellular response to pheromone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000747">
        <property type="term" value="P:conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006873">
        <property type="term" value="P:intracellular monoatomic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000047">
        <property type="entry name" value="Calcineurin subunit B type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45942">
        <property type="entry name" value="PROTEIN PHOSPATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="21"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="60"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="90"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="131"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF16027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="174" mass="19755" checksum="022C0853DC0D0F5B" modified="2013-05-01" version="1">MGNANSAMLENIVQGSNFDRDEVDRLRKRFMKLDKDNSGTIERDEFLSLPQVSSNPLATRMIAIFDEDGGGDVDFQEFVSGLSAFSSKGNKEEKLRFAFKVYDIDRDGYISNGELFIVLKMMVGSNLKDQQLQQIVDKTIMEADLDRDGKISFEEFTKMVENTDVSMSMTLDQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M3BT87</accession>
    <name>M3BT87_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein bL34m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_150982</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL34 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF09875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757996.1">
        <property type="nucleotide sequence ID" value="XM_016906522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BT87"/>
    <dbReference type="STRING" id="692275.M3BT87"/>
    <dbReference type="GeneID" id="27903659"/>
    <dbReference type="eggNOG" id="ENOG502S8P5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129938_0_0_1"/>
    <dbReference type="OMA" id="TMNGHTR"/>
    <dbReference type="OrthoDB" id="431691at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3980:FF:000001">
        <property type="entry name" value="Mitochondrial ribosomal protein L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00391">
        <property type="entry name" value="Ribosomal_bL34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000271">
        <property type="entry name" value="Ribosomal_bL34"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01030">
        <property type="entry name" value="rpmH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14503:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL34M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14503">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN 34 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00468">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF09875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="115" mass="12848" checksum="8FFD76201B75BACE" modified="2013-05-01" version="1">MPCSRCIRVATSAVRFSTQTTQTTQRRSLSLLSSITPTRPALLASRPTSILPAATLDSQLTGLSISQVRGAKRDTFKPSHVVRKRRHGYLSRIKTRTGRHILKRRRAKGRSTLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M3BTH0</accession>
    <name>M3BTH0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_143721</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Sodium-phosphate symporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF09945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758066.1">
        <property type="nucleotide sequence ID" value="XM_016903053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BTH0"/>
    <dbReference type="STRING" id="692275.M3BTH0"/>
    <dbReference type="GeneID" id="27900190"/>
    <dbReference type="eggNOG" id="KOG2493">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015355_3_0_1"/>
    <dbReference type="OMA" id="AWKTGNA"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101:SF57">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="539"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF09945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="572" mass="60989" checksum="0DACC605BEA090B2" modified="2013-05-01" version="1">MAVLSEYTYIFVIGTFFALLDAYNNGANDVANAWATSVSSRSISYRWAMVLATIFEITGAVTVGARTADTIKNGIIPPSSFRGDASVQMLAFTCALAGASIWVMWCTRHSAHVSSTYSLISSVAGVGVATAGAANVQWGWNDGRGLGAIFAGLGMAPAIAAGFGAVIFMLIKVVVHMRKNPIPWSVYTAPFFFLIAGTVCTLSIVYKGSPNLKLNAKPPHFIAGVTVGAGGGLAVLSAIFFVPFLYMRVIRRDASVKWYHVIQGPLLLKRTPVEGAALALVPNYAVDQHDDEVDDHQSSESTVVDQFAVPYEKGTTSPQVQSLSEAESQKAAIDYKQAQIDAREKLHKKIRAKTGPLGWAMRYLHENKQGPGEIYETKNMIIALKRIPAMLVVGCLYGASYDIHAAQSGIAGTPEGIRMARVYAHAPRYPNEVEHAYSFVQVLTACTASFAHGANDVGNAVAPWAVIYSAWSTGDAAASKLRLDHSPSRGCSMEMGAAITVLVFSQFKLPVSTSMCITGATVGVGLCNGTYKAVNWQRVGLLVISWIATIPIAGLIGGVLMGVLLNTPHFGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M3BTM3</accession>
    <name>M3BTM3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cu-oxidase_3-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_158192</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF09985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758106.1">
        <property type="nucleotide sequence ID" value="XM_016907776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BTM3"/>
    <dbReference type="STRING" id="692275.M3BTM3"/>
    <dbReference type="GeneID" id="27904913"/>
    <dbReference type="eggNOG" id="KOG1263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006504_3_2_1"/>
    <dbReference type="OMA" id="MAPAGGY"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13854">
        <property type="entry name" value="CuRO_1_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13901">
        <property type="entry name" value="CuRO_3_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF71">
        <property type="entry name" value="OXIDOREDUCTASE TPCJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="7">
        <location>
            <begin position="52"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="5">
        <location>
            <begin position="172"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="6">
        <location>
            <begin position="475"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF09985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="614" mass="68880" checksum="AB494CB4D96FEEB1" modified="2013-05-01" version="1">MTGYRSCNGAHDRNCWLRPSNSKDTHYNIHTKYDTPGDDFTPYWLDVDLLPIAPDGYLKTVGQVFNGTYPGPHLEGCWGDTFVVHVTNKIPNLGTTIHWHGIRQLHTNQHDGVNGVTQCPIAYGQTYTYRFHAQQYGHTWYHSHYQTQYSDGVAGPLTIYGPSSNDWDETFTPIMMQDWVHENSSIAFKQELAKAIPVGDGLLLGGVNQFKCSSLDPKCCDACNSATCDIAEGENPEYCCTPDPSCFKTVNGVKTILKGSKYNQTFEEGKRYLLQLINASSESMFIFSIDDHDFEVIAADLVPIVPYKTDSVFVAIGQRYQIIVTAKPKKKSPLCRGDITRCNYWIRTRIATGCGTVAQGDEETGIIQYSPNRAANVFPETISGNDREACRDEPTELLRPVVQWNASDLRNNRDNYTYEAGFNNRTTNGAFRWELKDEPMFLNYSNPSLLNVGNPGYFTEEIAPANYTNPAWNDGFVYLVITANNVLNVPGKIGVPVAHPIHLHGHDFVILAQIDREWDGTIPVMNTDNPTRRDTALLYAGGYLALAFKLDNPGIWLVHCHIAWHASSGLALNIIERQDEIVGGLKMGSLDETREVCREWEEMGLEYQQEDSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M3BTP6</accession>
    <name>M3BTP6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">quinol--cytochrome-c reductase</fullName>
            <ecNumber evidence="3">7.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">SEPMUDRAFT_151076</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </cofactor>
        <text evidence="17">Binds 1 heme c group covalently per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="3"/>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758126.1">
        <property type="nucleotide sequence ID" value="XM_016906581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BTP6"/>
    <dbReference type="STRING" id="692275.M3BTP6"/>
    <dbReference type="GeneID" id="27903718"/>
    <dbReference type="eggNOG" id="KOG3052">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040334_1_1_1"/>
    <dbReference type="OMA" id="WVKKFKW"/>
    <dbReference type="OrthoDB" id="5925at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:quinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.760.10:FF:000002">
        <property type="entry name" value="Cytochrome c1, heme protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.100:FF:000003">
        <property type="entry name" value="Cytochrome c1, heme protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002326">
        <property type="entry name" value="Cyt_c1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021157">
        <property type="entry name" value="Cyt_c1_TM_anchor_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10266">
        <property type="entry name" value="CYTOCHROME C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10266:SF3">
        <property type="entry name" value="CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02167">
        <property type="entry name" value="Cytochrom_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00603">
        <property type="entry name" value="CYTOCHROMEC1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81496">
        <property type="entry name" value="Cytochrome c1 subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase), transmembrane anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 17 18" id="KW-0349">Heme</keyword>
    <keyword evidence="13 17 18" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 17 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome c" evidence="20">
        <location>
            <begin position="99"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="141"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00029351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR602326-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EMF10005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="330" mass="36246" checksum="89442DD9EEBBB1CD" modified="2013-05-01" version="1">MLSRTAARATRALATGKTAASKTATRNASSQSSSESAGSKFWTNNALLASSSALAATSVAWYFYQYGRPAYAMTPAEEGLHATKYPWEHESLIKTFDHAALRRGFQVYREVCASCHSLSRIPYRTLVGNIMTVDEAKALAEENEYDGEPNDEGDIEKRPGKLSDYIPNPYKNDEAGRAANNGALPPDLSLIVKGRHGGCNYIFSLLTGYPEEPPAGAVVPAGLNFNPYFPGTGIAMARVLYDGLVEYEDGTPATTSQMAKDVVEFLNWAAEPEMDERKRMGWKVMAIGSVLFAMSVWVKRYKWSTIKTRKISYTPPPSSERPAPGSIFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M3BVU3</accession>
    <name>M3BVU3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Chromosome segregation in meiosis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_157480</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Plays an important role in the control of DNA replication and the maintenance of replication fork stability.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the CSM3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759570.1">
        <property type="nucleotide sequence ID" value="XM_016907736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BVU3"/>
    <dbReference type="STRING" id="692275.M3BVU3"/>
    <dbReference type="GeneID" id="27904873"/>
    <dbReference type="eggNOG" id="KOG3004">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036204_1_0_1"/>
    <dbReference type="OMA" id="RMDWINE"/>
    <dbReference type="OrthoDB" id="437078at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031298">
        <property type="term" value="C:replication fork protection complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043111">
        <property type="term" value="P:replication fork arrest"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012923">
        <property type="entry name" value="Csm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040038">
        <property type="entry name" value="TIPIN/Csm3/Swi3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13220">
        <property type="entry name" value="TIMELESS INTERACTING-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13220:SF11">
        <property type="entry name" value="TIMELESS-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07962">
        <property type="entry name" value="Swi3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0236">DNA replication inhibitor</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromosome segregation in meiosis protein 3" evidence="9">
        <location>
            <begin position="69"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="34"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="145"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="204"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="258"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="292"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF11449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="304" mass="33960" checksum="7C18B74472117A3B" modified="2013-05-01" version="1">MPSAVSPNRRAGSAQPDELDRLLEDDQAIEDFFNDLPREVQSSRTAQNEQGRDEDQEVQIKKKRVPIPKLDENRLLSQAGIPKLRKITKSRLKFRGKGHEYTDISNLLNTYQLWLDDLYPRAKFRDAVTMVEKVGHSKRMQVTRRAWLDETKPNRRDLTPPPDLGIDTEDAKSGYTGDSAPNANVSQADLDATAPADDELDALLAQGGDGNAPANLSTAHRRTEPSEGNDGPDEDELDALMANSQVIEPPKRKPLLPFEEESDDDDELDALMAAQTSKQPDPVAASRQGQDDFADDEEAMREMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M3BWX7</accession>
    <name>M3BWX7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">eIF-2-alpha kinase activator GCN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_133271</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GCN1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760672.1">
        <property type="nucleotide sequence ID" value="XM_016902554.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.M3BWX7"/>
    <dbReference type="GeneID" id="27899691"/>
    <dbReference type="eggNOG" id="KOG1242">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000504_1_1_1"/>
    <dbReference type="OMA" id="KYATQRG"/>
    <dbReference type="OrthoDB" id="5148094at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043008">
        <property type="term" value="F:ATP-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0170011">
        <property type="term" value="F:stalled ribosome sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140469">
        <property type="term" value="P:GCN2-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031571">
        <property type="term" value="P:mitotic G1 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904689">
        <property type="term" value="P:negative regulation of cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071264">
        <property type="term" value="P:positive regulation of translational initiation in response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990611">
        <property type="term" value="P:regulation of cytoplasmic translational initiation in response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006448">
        <property type="term" value="P:regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000090">
        <property type="entry name" value="eIF-2-alpha kinase activator GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022716">
        <property type="entry name" value="Gcn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056810">
        <property type="entry name" value="GNC1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057546">
        <property type="entry name" value="HEAT_GCN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056809">
        <property type="entry name" value="HEAT_GCN1_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346:SF7">
        <property type="entry name" value="STALLED RIBOSOME SENSOR GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR GCN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12074">
        <property type="entry name" value="Gcn1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24993">
        <property type="entry name" value="GNC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23271">
        <property type="entry name" value="HEAT_GCN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25801">
        <property type="entry name" value="HEAT_GCN1_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24916">
        <property type="entry name" value="HEAT_GCN1_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TOG" evidence="6">
        <location>
            <begin position="1354"/>
            <end position="1590"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="1531"/>
            <end position="1569"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="1991"/>
            <end position="2028"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2643"/>
            <end position="2685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00072275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF12551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="2685" mass="291087" checksum="DA4E143D4AE33EE4" modified="2013-05-01" version="1">MADGEAAPAVVNGDHAAALDMWEVRQTVLSNSTKRRSTELHSIHEKLVNGTFPVSQVPALLHTLLDTYPLYVDGRSRQAVESCLAAIAAIPQSANVLPGFVKALETESVKAGNAPSNAFVLSRWASLFMQQAAQDKAKWDSWGPRAVAALNNALNILLASCPKDSTRETALRVSRRAFRILAKAPFGPEALTSCITTLSAKAASPVSTHAVPLGIIAGVCSRLPDRKGVVEAKKADYFAFYLREFLGSKLQLPPYVANALHDFFEAYVTQEDLTKELIPAIEKSLLRAPEVVLNDLVSPVVLALPRELDLSEILAKNLTKPLLANVKSTKPEIREGALRTFKAVASRSHSDTFVEKSADEILNPLKAGKVTAADQRVLHAEMLSSLPPTSALATRVPAGLVAVASKEANESAALAEIGCIANYARFSLENKVKLDAMIVDAFTKGLAEKRLPMRRVWALQLADLVWSTSPEASNSESAVALLDASIGKLIDVLNEVHANPIPALQSGQVSVAAVATALGLARATALPSLKNAGIVQKAAIGDKVLTLEPKPSFLLSPRIYTKLTAEEDLRWFLHALVAAFPSLTGKDSLAVQNAWAQAMIYLITSSNVPAKVKSEAVRSLQGLYIANAEAVMSIVVGGLWQWCEDLETGAKDSAAIAAKTGREELQKVIRAICLDPETAAKLGTPVMKEIIENQLQRLLVLCRPQLIPKASWIQTCLRTGTDPGQLVERSTSNLLEQILTVTEHSVWKSLPAFQLAATYAAADLAFVAPKVFTPIIVQQISSDLNPTQLSDVGPTEAAIYRTPEGTAFVDVLSSKSQAPEISKNQKDYDTLKWEQELRNQLAAKKGQTKKLTADEQAKVKAQLQKESEIRQKVALVDAKLRRGIGFINALTTGPPTEAEEWFGTSVKLLFDIIQAGAGLILGDAASLAYLQCSDKISTRLGPLRPFVGVSTLRSAGITLLPENLLAEPLGDLVTRILYRLRSLGEQRPFDSVSLSYILALVFLVLENGGIDRATPEDADEQIMLAIEFISFHTETCADPSLPRQGLLDTLIRSLQRFPQHFKEIKDCFTDLSRHLSANLNEAETDTVVRGTIVPETSVRNAVLQAISAELELTDREFYEEIWLANHDDDEDNAGTAHEIWEENELKVVPDGAVKCLPYLESKDSQLRRAAARAVADATQQHISTFQDILSRLRGSYIEAAKPKKPELDRYGMPLKKDMSDPWEHRHGIALTFRELGAIFPEDEIAPFLAFLIESGPLSDKNGTVRDSMVDAATTVVSTRGKGLVEPLMKLCESTLGGSSKTPEQDLVNEAVVILYGALARHLPPGDDRVPKVVNRLLSTLSTPSESVQYAVAQCLPPLVRASADQASTYLTQLIDETLHSKKYAARRGAAYGLAGVIKGRGISLMKETRLLSTLRSAAENKKDINERQGAYLAYELLSLLLGRIFEPYVIQIVPQLLGGFGDATADVRDACLDASKTCFASLSSFGVKQVLPQLLEGLDEQAWRSKKGACDSLGAMAYLDANQLAVSLPEIIPPLTEVLNDSHKEVRLAANRSLQRFGEVIENPEIKGQVSILLKALSDPTKYTDDALDALIKINFLHFIDAPSLALVVRILERGLGDRSGTKRKAAQIIGSLAHLTERKDLLVHLPILVAGLRSAVVDPVPTTRATASKALGSTIEKLGEDALPDLIPSLMTTLKSDTGAGDRLGSAQALSEVLAGLGTSRLEETLPTILQNVASTKPSVREGFMSLFIFLPACFGQSFANYLARIIPSILAGLADDVESIRETALRAGRLLVKNFASKSVDLLLPELERGLADDSYRIRLSSVELIGDLLFNLTGISGKTEAEDLDEGANEAGANLLEVLGEEKRNRVLAALYICRMDTSGLVRTSAMNVWKALVSSPRVLKDLIPILTQLLVKRLASSNHEQKIIGGNALGELIRKAGDGVLSALLPTLEEHLQTSSSTDSRTGICIALRELITASTEESLEDHQQRLISVMRTALVDTDEDVRDAAAEAFDSLQKLMGKRAIDQVLPYLLQLLRTEGEAANALSGLLTLLTDSTRSNIILPNLLPTLIASPISSFNARALASLAEVASSAMTRKLPNILNALMDNIIVCKDEELKSELDAAFDTLILSVDEFDGLNTMMSVMLALSKNDDHRRRCVADLHFAAFFGKADVDFSRYYPDVIRAMLISFDDSDTEVVKAAWTALSQLMQRLKKEEMESLVSSTRQTLNQVGVAGHPLPGFSLPKGINAILPVFLQGLMNGSAEQRIQAALGLSDLIDRTSPDGLKPFVTQITGPLIRVVSERSVELKAAILLTLNNLLEKIPTFLKPFLPQLQRTFAKSLADPGSEVLRSRAARALGTLITMTPRIDPLIAELVTGSKTTDLGVKNAMLKALYEVVSKAGAKMSEVSQNAILGLIDSDAGDADDSLNIAYAKLLGALIAVIPAENTVSLMKVRVLNFNFTHSTILALNAVLVDAPERLTNGLDEITREVLVRGINHTQPFIADKAILAAGKYLLTETGNKSFEGVKPIMQALADALPLGKPVDTRRLALVVIRTVARQRSELVRPHLNILVTPVFRSVRDPVIPVKLSAEAAFLQIFEVVEEESAVFDKYLASKDGQALAAQDKRSMQEYFKRIALRLSGQARERKEAEGGSGGLGLTSDEKEDEREVWSVGKVDLGEGVSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M3BXJ9</accession>
    <name>M3BXJ9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_149360</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760927.1">
        <property type="nucleotide sequence ID" value="XM_016905508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BXJ9"/>
    <dbReference type="STRING" id="692275.M3BXJ9"/>
    <dbReference type="GeneID" id="27902645"/>
    <dbReference type="eggNOG" id="ENOG502RKEQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038702_0_0_1"/>
    <dbReference type="OMA" id="RECIATY"/>
    <dbReference type="OrthoDB" id="3932126at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF33">
        <property type="entry name" value="MEMBRANE PROTEIN WSC4, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G09020)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="114"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="239"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="393"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="402"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="420"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="458"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="475"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF12806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="536" mass="57263" checksum="A7AA66663D24F4D7" modified="2013-05-01" version="1">MQRRQHPALDEDNDDDNDQEFWEQIWSEQTVPNDSMGERVLATTTAATDSDANIVWSTAYVTVYVPTSTRYISVANTSSSLSPSTSSSEVALSTPSQTARFSSTPIVLSPGIYSGPAKSTSKSPRVVPGSLATSSSDSGPSKSSATLSLPTDNALLNATSSSNATMGSIAESMPSGQKRAIVGGLSGTIAGLILIGLLIFLVLRRRRKQQEARDFDEDSVSEKGAYSSDVVQKWGGIATATPIGRGSPRDSQHRPSSATQIAVDEEHRIIRMSTRHWPRPYAMGEGEGYRESVPTGQLRVVNPDVMRPATPRRPSTETVASYLRRQQSALAAFSFGLPKSARHSRIEQLTRAGQTPSTTIALVDPSLSRECVVGTPSFKSFVSLGSLPTIRQHPPEDPFLTPLPECDCDALPPLPPPSARGTQRRPSATPLQQNPANSTSRTLSQRGYNLLLQPFRPKSSNVPTAQQKQKQTYISSPTDSCPPSSCSSSPSYIRMSGRSDPFDLDHPSVRGSHITITMTGAGGGGGGGGISLYEGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M3BYQ4</accession>
    <name>M3BYQ4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_116261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
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    </reference>
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    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_1636463_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="124"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF13201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="162" mass="17914" checksum="4E31DFBB1D799B4C" modified="2013-05-01" version="1">MQGRLHFRTQEQATKAHYDVVLVIVQDHRGGGRYIVPDALMPLPENFGVNGVKIRSSIFKDAISVSYTHGEGRQTPELGQQSVWHGGNAWDRRTIIGNNNEAGGWQRGRRGRVTTSAWARSKREVDRKWNDGTTTGTQVEETWPGTSSAAAGRTGMRITGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M3BYT5</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_132580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016902501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BYT5"/>
    <dbReference type="GeneID" id="27899638"/>
    <dbReference type="HOGENOM" id="CLU_1220356_0_0_1"/>
    <dbReference type="OrthoDB" id="10654955at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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            <begin position="40"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF13236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="227" mass="25766" checksum="F711C9873F8D94EA" modified="2013-05-01" version="1">MSILRVTIRSSGPTDYSTEQLRLRLREAVANMEVNEQMEVLENNRRRQRRAADSVQLTRRSHPVPPPLLPVRRRSSSSSSSADSNNNINLSPVSSSSHHSQISPKTQYPSAVTSMRKQKTLPLLSQHSPPAPARVPTCSGAMVTVPKKKDVQLPVLTSYRNGEPASRRRRPGTDSVDDDDDDGEYCIRRSRRETRTGNDWEVTRKNHYSYWPPKKTTTTTKTRRFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M3C413</accession>
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        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_59315</name>
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    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SO2202</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2012-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genome evolution in poplar pathogens from wild and recently domesticated pathosystems.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Dhillon B."/>
                <person name="Feau N."/>
                <person name="Sakalidis M.L."/>
                <person name="Gill N."/>
                <person name="Aerts A."/>
                <person name="Ohm R."/>
                <person name="LaButti K."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Copeland A."/>
                <person name="Beauseigle S."/>
                <person name="Grigoriev I.V."/>
                <person name="Goodwin S.B."/>
                <person name="Tanguay P."/>
                <person name="Hamelin R.C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF14986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763107.1">
        <property type="nucleotide sequence ID" value="XM_016909489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C413"/>
    <dbReference type="STRING" id="692275.M3C413"/>
    <dbReference type="GeneID" id="27906626"/>
    <dbReference type="eggNOG" id="KOG1205">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_8_2_1"/>
    <dbReference type="OMA" id="MACDINA"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901:SF1">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF14986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="306" mass="33067" checksum="64D1311DC54BEF9C" modified="2013-05-01" version="1">MTDFTRIFRRTTYATISPSNPGNTQTGRTVLIIGASEGVGLDIAKAFCEANAKAVIISSRSKAKLDVATASLKQIVPSCDVSSIVSDAADIGQIESLWQQLAEAGTLIDVLVLNAAASDNINELDPLEVARFFQANVIAKLHILHRFQNQKHGPSARPMVLIDISSAALQTYPHPRLALGYPSTKAGFSNYLCHLADIVPEPSMRIISLHPGVVYTSAVERASGGRGKDLPIWDDPSLAAHMALWLSSPAAAFLHGRFIWANWDADELVARREEILSDHGLLKVGITGVKSFNMPKLMEKCAEFPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M3C4J1</accession>
    <name>M3C4J1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_147147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016904113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C4J1"/>
    <dbReference type="GeneID" id="27901250"/>
    <dbReference type="HOGENOM" id="CLU_3033893_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF15216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="55" mass="6233" checksum="14DEB5FB14800803" modified="2013-05-01" version="1">MYLGSRFLELMACQMTLQKQPGVMGTQRQTTTTAKRPADHARDAPQTLRTRRVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M3C4M2</accession>
    <name>M3C4M2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-superfamily phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_161471</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763372.1">
        <property type="nucleotide sequence ID" value="XM_016907940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C4M2"/>
    <dbReference type="STRING" id="692275.M3C4M2"/>
    <dbReference type="GeneID" id="27905077"/>
    <dbReference type="eggNOG" id="KOG2961">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056221_3_2_1"/>
    <dbReference type="OMA" id="MLMANMM"/>
    <dbReference type="OrthoDB" id="198652at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008962">
        <property type="term" value="F:phosphatidylglycerophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000165">
        <property type="entry name" value="HAD superfamily phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027706">
        <property type="entry name" value="PGP_Pase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010021">
        <property type="entry name" value="PGPP1/Gep4"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01668">
        <property type="entry name" value="YqeG_hyp_ppase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288">
        <property type="entry name" value="4-NITROPHENYLPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288:SF25">
        <property type="entry name" value="PHOSPHATIDYLGLYCEROPHOSPHATASE GEP4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09419">
        <property type="entry name" value="PGP_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF15251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="211" mass="23518" checksum="6BA836C8B0FD8850" modified="2013-05-01" version="1">MNVSATVNVLRLLVNPSLCLPHHTIATFDQLPVPLSQAFTKHGSDKKPDIKAVVLDKDNCFALPKTNVIHKPYIAKFEELRTAYPGSKILIVSNSSGTNSDPHHAEADVLEQNTGIKVLRHSTKKPGCHSEIMEYFRSHPDTGVSHESQIAIVGDRLFTDILMANMMGSYGVWIENGVKQDYGFMTRVEKGLHGLLVRRQFVPPEPMSQFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>M3C9H3</accession>
    <name>M3C9H3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_111810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756586.1">
        <property type="nucleotide sequence ID" value="XM_016900939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C9H3"/>
    <dbReference type="GeneID" id="27898076"/>
    <dbReference type="HOGENOM" id="CLU_1960944_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004031723" evidence="1">
        <location>
            <begin position="18"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF08465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="128" mass="12328" checksum="C282F1477DE516A0" modified="2013-05-01" version="1">MQFHHLTTLLLATLATAAPLPTPNTNDLSTRQIPAAGGLPAMNMVTGLLSPVTGALGGLGGLVKRQGLPSMGSLPGLNEVTGILGSVTGGGLPGLVKKEVPGLSLVGGLLNGVTSAAGSSAGKSGGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M3C9N1</accession>
    <name>M3C9N1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BRO1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_94273</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the palA/RIM20 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756661.1">
        <property type="nucleotide sequence ID" value="XM_016910634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C9N1"/>
    <dbReference type="STRING" id="692275.M3C9N1"/>
    <dbReference type="GeneID" id="27907771"/>
    <dbReference type="eggNOG" id="KOG2220">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007181_0_0_1"/>
    <dbReference type="OMA" id="VSHAEEM"/>
    <dbReference type="OrthoDB" id="64867at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09241">
        <property type="entry name" value="BRO1_ScRim20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.560">
        <property type="entry name" value="alix/aip1 in complex with the ypdl late domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.50">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025304">
        <property type="entry name" value="ALIX_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030">
        <property type="entry name" value="PCD6 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030:SF39">
        <property type="entry name" value="PROGRAMMED CELL DEATH 6-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13949">
        <property type="entry name" value="ALIX_LYPXL_bnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="3">
        <location>
            <begin position="5"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="650"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="810"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="659"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF08540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="833" mass="93493" checksum="8A5E59B26DF36419" modified="2013-05-01" version="1">MQSSNILQIPFRRTHVTQLSEAIKVQIGTTFDQHPDLFTRDLEIIDQLRKDAVNALEPHSSGIKKLQAYAAQLVWLGGKFPVDMGANFTWYPSLGYNTDRPITENNIRFELANVLFNLAAMYSQLGLASNRATGDGLKSAANNFCFAAGVYKHLRENVVPDMKTAPPEDMDPATLQALEALMLAQAQECFWQKAVKDGMKDAIIAKLAAKVSDLYNDAKEWSLKTDSVRSEWIHHMNAKHHHFAAAAQYRAACDCLEKRKYGEEVARLRDSLTCAMIALNETKWINKMVLADLNGLKNRVSEDLKRAEKDNDTIYLIPEPSKSELRPLDRASMVQSRVPKEVSNSQEMLGDRSELGKPLFSKLVPYAVHVAASIYTDRRDRLVNNTIIAELDALTVRIHELLSSLNLPGSLQALEKPLGLPPGLASHADEIRQIGGVHLLHSTIADTEKLKANNRALYQEGIDLLRTESNEDETARRKYGTDRWSRPSGRQAAKQLYDQIDAIDGWLKAADTTDRSVLNRLRENETLIRLLGGSDRDLEDYVPSSRRATMTAKVEREANALRATLNEVSRLESRRRKKVEALRMKVKEDDIQPDLRKESNKLEREYPMMPIQASQFENLFDERLQKYDLDRSSLKTEEREQDTLLQRVKDANQSFQNAKRGDSSSKEREDALQNLENAYTAYKEIMKNLEVGRKFYNDLSGITLKFRDECRAFFTQRRSEASAIDADVSNALAGLQLQQHTQANLLQERAAEAASRRGSVQPAKPEATIPAPIPQRVAVQPPPVANVQSPVSAGPANQTWNENMPIVFGGAGNGKAAAGQTWDPTKGLHFGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M3C9Q8</accession>
    <name>M3C9Q8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tyrosinase</fullName>
            <ecNumber evidence="3">1.14.18.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SEPMUDRAFT_152200</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2 L-dopa + O2 = 2 L-dopaquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:34287"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57504"/>
            <dbReference type="ChEBI" id="CHEBI:57924"/>
            <dbReference type="EC" id="1.14.18.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-tyrosine + O2 = L-dopaquinone + H2O</text>
            <dbReference type="Rhea" id="RHEA:18117"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57924"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="EC" id="1.14.18.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tyrosinase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.18.1" evidence="3"/>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756696.1">
        <property type="nucleotide sequence ID" value="XM_016907299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C9Q8"/>
    <dbReference type="STRING" id="692275.M3C9Q8"/>
    <dbReference type="GeneID" id="27904436"/>
    <dbReference type="eggNOG" id="ENOG502RF2C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013691_3_0_1"/>
    <dbReference type="OMA" id="VIAYIPI"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004503">
        <property type="term" value="F:tyrosinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042438">
        <property type="term" value="P:melanin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041640">
        <property type="entry name" value="Tyrosinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF76">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18132">
        <property type="entry name" value="Tyrosinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-0470">Melanin biosynthesis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004031727" description="tyrosinase" evidence="11">
        <location>
            <begin position="19"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="12">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="13">
        <location>
            <begin position="324"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMF08575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="642" mass="69447" checksum="43DAB8C1E3954140" modified="2013-05-01" version="1">MKFSSLSSLALACTSIFAHPVEHNEEHSDIKARQQNYVRLEGGKGNAVQPRLEVRQLKNQQPDQWNIFLVALDYWMTQSTGEAGYYGISTIHGVPRQNYADVAQCSTCAGADGYCPHDSVLFPAWHRAYVALFEQEFLKVALDRANQFPAATRQRYVNAATNLRFPYFDWAAVPPNNGPALPTLITDSSVTFQGPNGQQTVRNPLYGYVFRNGEQSGLLYATLNTYTKTLRYPKSNDPNAANNSPQCAAAFAGSRQSLQDQIYQLFTACDNYLYFSNDDSSDSSGRCSNSLEAIHNTVHNNAGGLGGNGISGGHMTYLSTASYDPIFWLHHANVDRLAAMWQTIHSNSYGASQIAPHNTWTVAQGSNQGPTSGLRPFRRPGTSTSFWTTNQVRDWRQFGYTYPEFSNSDGSAGAITGYVNALYGPNPSATAGSSKREAAADPSLLGGVSKVLDEPNILSSLGDILADNPLKASNGSLYQYVANIKTARYALGGSYTIFLFNGNPVSEDVKTWPTDPNLYGPMGVLAQEMSGSGMNMSLITSSSIPLTTKLTSLFGSGVLGSLSELVVAPYLKENLQWRIAKDGSSVDPSTIPGFVVTVVTSSAQPAADAKSFPVYSPFIELLGITQDMAGGASETQYGPPSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M3C9V5</accession>
    <name>M3C9V5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mRNA stability protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_152250</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Plays an essential role in initiation of the G0 program by preventing the degradation of specific nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the endosulfine family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756756.1">
        <property type="nucleotide sequence ID" value="XM_016907329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C9V5"/>
    <dbReference type="STRING" id="692275.M3C9V5"/>
    <dbReference type="GeneID" id="27904466"/>
    <dbReference type="eggNOG" id="KOG4076">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_712071_0_0_1"/>
    <dbReference type="OrthoDB" id="5949865at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006760">
        <property type="entry name" value="Endosulphine"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10358">
        <property type="entry name" value="ENDOSULFINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10358:SF6">
        <property type="entry name" value="ENDOSULFINE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04667">
        <property type="entry name" value="Endosulfine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="87"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="279"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="308"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="351"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF08635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="388" mass="42710" checksum="C36AD2D9EBDC71B0" modified="2013-05-01" version="1">MLHCVRRQRVEEKCPRPSSRSSSSFASNPSSVLAVLHQSAHLPARCSRGLSTTAQRPLPPCDQQRREESITSDFNFIPSSSDPFASSCTDPGIGHLPTNSTHHYHHSDDASFNAIGSAPPRLVSPNLSSPAPTRPKALESCTDTTRPAQKRARHTKKRRDLQARDLLRKTTTTAAERFRLTTTTTYPSTSSKMALNPHKQNKVDVSVRLHTPHSHSPPIHRRHIVPDVLIPLCESLTPFWQSLTEEEQKLFRLYGKLPNKKDLFSKKLQERKYFDSGDYAMSKAGKNDDASLSGGLGREHPTPENIPHLSQQVSAGTPTTENGPRGSISGAPALHPTLSGNGQQAGSPVKEASHLHRESSVNEQDLPDDLQQARASDQSETADIPIRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M3CA16</accession>
    <name>M3CA16_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_128348</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Complex I functions in the transfer of electrons from NADH to the respiratory chain. Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
            <orientation evidence="1 11">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the complex I NDUFA13 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756826.1">
        <property type="nucleotide sequence ID" value="XM_016902211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CA16"/>
    <dbReference type="STRING" id="692275.M3CA16"/>
    <dbReference type="GeneID" id="27899348"/>
    <dbReference type="eggNOG" id="KOG3300">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119720_1_0_1"/>
    <dbReference type="OMA" id="YGIREQH"/>
    <dbReference type="OrthoDB" id="3308at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009346">
        <property type="entry name" value="GRIM-19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12966:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12966">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE 1 ALPHA SUBCOMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06212">
        <property type="entry name" value="GRIM-19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF08705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="120" mass="13905" checksum="BF4241D59A8BCC00" modified="2013-05-01" version="1">MVGQDMPPTGGYEPVQYRRNLPVRGFRPAYLLVGLAGVMSWGFYRLGQGIREQNELAREKMWSRIHLIPLLQAEEDRDVVRRDFAQKALEKELLGKEVPIYNKDRFVRPTYAITPSNVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M3CAW3</accession>
    <name>M3CAW3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Arylsulfatase</fullName>
            <shortName evidence="5">AS</shortName>
            <ecNumber evidence="5">3.1.6.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Aryl-sulfate sulphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_73294</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an aryl sulfate + H2O = a phenol + sulfate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17261"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:33853"/>
            <dbReference type="ChEBI" id="CHEBI:140317"/>
            <dbReference type="EC" id="3.1.6.1"/>
        </reaction>
    </comment>
    <comment type="PTM">
        <text evidence="6">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.1" evidence="5"/>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757076.1">
        <property type="nucleotide sequence ID" value="XM_016910021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CAW3"/>
    <dbReference type="STRING" id="692275.M3CAW3"/>
    <dbReference type="GeneID" id="27907158"/>
    <dbReference type="eggNOG" id="KOG3731">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006332_4_0_1"/>
    <dbReference type="OMA" id="WCHGEHE"/>
    <dbReference type="OrthoDB" id="96314at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005539">
        <property type="term" value="F:glycosaminoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008449">
        <property type="term" value="F:N-acetylglucosamine-6-sulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018958">
        <property type="term" value="P:phenol-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16147">
        <property type="entry name" value="G6S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000051">
        <property type="entry name" value="Arylsulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012083">
        <property type="entry name" value="Arylsulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-SULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108:SF8">
        <property type="entry name" value="SD21168P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000972">
        <property type="entry name" value="Arylsulf_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Sulfatase N-terminal" evidence="7">
        <location>
            <begin position="2"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="6">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000972-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF08955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="588" mass="65774" checksum="1B91FCA5E678CFF3" modified="2013-05-01" version="1">MIFILTDDQDLHMDSVAYMPHLKKLIIEQGMTFKKHYCTVALCCPSRVSLWTGKAAHNTNVTDVNPPYAGGYPKFVSQSLNSAYLPVWLQSLNYATYYVGKLFNAHSVHNYASPRAAGWTGSEFLLDPYTYEYLNATFVRNHGEPKSYEGQYSTDLIAAKAFGFLDTALDEYQKEGKPFFLTIAPTAPHSNVHMNTQIDGNFSEGSNTQSPPIPAARHSHLFEDVVVPRTPHFNPVDAHGVSWISRLPRQNQTNIDFNDHFYRSRLRALQAVDEMIHDLFMKLDAAGVTEETFVFFSTDNGYHIGQHRLQPGKQCAFEEDVNIPFMVRGPGIPINRSTDIITTHTDLAPTFISLAGGQLRDDFDGQVIPLHGLSSRSLNPPNHQIIGRDVGSSLTTPAKDWSTEHINIEMWGVIMSEGDHGSVLYPNHTYKALRLIAEEYSLLYTVWCSGERELYDMKKDPYQTENLMAAAQSDTAMSMPLQTPGSVIFSSQVTLVDQSHVHSRIQLLSRLDALLMVLKTCTARACTHPWQVLHPLGDVKSLADAMGPQYDSFYTSQQKVAYEKCEKGFILDSEGPVKVAAYSFDVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M3CAY5</accession>
    <name>M3CAY5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine hydroxymethyltransferase</fullName>
            <ecNumber evidence="9">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_151859</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Interconversion of serine and glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the SHMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="9"/>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757106.1">
        <property type="nucleotide sequence ID" value="XM_016907086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CAY5"/>
    <dbReference type="STRING" id="692275.M3CAY5"/>
    <dbReference type="GeneID" id="27904223"/>
    <dbReference type="eggNOG" id="KOG2467">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022477_0_1_1"/>
    <dbReference type="OMA" id="CQFANVQ"/>
    <dbReference type="OrthoDB" id="10265628at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000097">
        <property type="entry name" value="Serine hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000586">
        <property type="entry name" value="PRK00011.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF28">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 9" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="7 8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="10">
        <location>
            <begin position="26"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF08985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="482" mass="53116" checksum="7AFA60EB4F954788" modified="2013-05-01" version="1">MAFDGANGPELALPQAHQDLMQKSLVDTDPEIASMMEDEIKRQRESILLIASENVTSRAVFDALGSPMSNKYSEGYPGARYYGGNEHIDRIELTCQKRALETFRLDPEKWGVNVQCLSGSPANLQVYQAIMRPHERLMGLDLPHGGHLSHGYQTPTRKISAVSTYFETFPYRVNLDTGLIDYDRLEENALMYRPKVLVAGTSAYCREIDYKRMKEIADKVGAYLMMDMAHISGLVAAGVNKSPFEYADIVTTTTHKSLRGPRGAMIFFRKGVRKTEMKAGKEVQVLYDLEGPINFSVFPGHQGGPHNHTITALAVALKQAQTPEFLQYQQQTIKNAKQLEKSFKGMGYKLVTDGTDNHMVLVDLKPLGLDGARLEAVLDQVNIACNKNTTPGDKSALTPCGLRIGAPAMTSRGMGEDDFDRIAGYINDCVQIALKVQKELPQEANKLKDFKAKVAGGAASVPELGELKAEIAEWAGSFPLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M3CCP4</accession>
    <name>M3CCP4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1749-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_151190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758298.1">
        <property type="nucleotide sequence ID" value="XM_016906662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CCP4"/>
    <dbReference type="GeneID" id="27903799"/>
    <dbReference type="eggNOG" id="KOG4840">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049633_3_0_1"/>
    <dbReference type="OMA" id="PPWVNKE"/>
    <dbReference type="OrthoDB" id="10034502at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013744">
        <property type="entry name" value="SidJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591:SF7">
        <property type="entry name" value="DUF1749-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591">
        <property type="entry name" value="UPF0613 PROTEIN PB24D3.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08538">
        <property type="entry name" value="DUF1749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF10177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="332" mass="36013" checksum="21E084002923DEDE" modified="2013-05-01" version="1">MESSKWPAANATPGTLHYIPPNLSAFEPSKPLSQPSDRINTLLWVGGMFDTFGSVAYPFVLAHSLGPSWTLMTAALSSAGHSWGTSTIARDAEDMAKIVAYIKEQRPNGKVVIMGHSTGCQDCMEYAVGKNSDADRRPAVDGLILQAPVSDREALQKELPETFKHEADQLALKMCREGHEKEVMPSRLTKSVFGRLAITARRWVDVSSPGPDHNGADDYFSSDLPDERLSGTFGKLPSRTPLLILYSGNEENVPDSLDKEKLVQRWIGIVKAGSGSIDENSGLVKGASHNLNGNPEEVVQDLVRRVNAFLARMSASSAGVPRAGASLLQKDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M3CCX3</accession>
    <name>M3CCX3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fms interacting protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_158396</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THOC5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758388.1">
        <property type="nucleotide sequence ID" value="XM_016907790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CCX3"/>
    <dbReference type="STRING" id="692275.M3CCX3"/>
    <dbReference type="GeneID" id="27904927"/>
    <dbReference type="eggNOG" id="KOG2216">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082754_0_0_1"/>
    <dbReference type="OMA" id="HKYMKLP"/>
    <dbReference type="OrthoDB" id="20582at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019163">
        <property type="entry name" value="THO_Thoc5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13375">
        <property type="entry name" value="FMS INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13375:SF3">
        <property type="entry name" value="THO COMPLEX SUBUNIT 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09766">
        <property type="entry name" value="FmiP_Thoc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="157"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF10267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="25177" checksum="C36DA24BBA956F8F" modified="2013-05-01" version="1">MSATSIITDPVLTSVLAAAHETRQQCNSILDFISSQNTSASASASVYEDTHLLTAQKTLSTRLAILRGLNRKAILSVRNTKHETSEKRQEIDALHLQLQNLYYEQRHLRGEIRACEDYDHKFPLLNMLPASDFLSQHPEDFALDTSEDDHDLTIARIEDEHAARKELDGRIQELTKQREALMRKNDVEKAQLAALDESLEKWIMGGKEKIEKLLVEGRKVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M3CDM5</accession>
    <name>M3CDM5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_150148</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759257.1">
        <property type="nucleotide sequence ID" value="XM_016905987.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.M3CDM5"/>
    <dbReference type="GeneID" id="27903124"/>
    <dbReference type="eggNOG" id="KOG0920">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001832_1_1_1"/>
    <dbReference type="OMA" id="MCKLVCR"/>
    <dbReference type="OrthoDB" id="5600252at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF203">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="716"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="988"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="37"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="503"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1534"/>
            <end position="1583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="91"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="503"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF11136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1583" mass="175816" checksum="B80A8C09D66B5649" modified="2013-05-01" version="1">MAIFHLPPALRLQMLSRSLLVKPYILASGRGIRPSAALCSSRDRGRPYATVRTNNNKRTVGKTQARPSRPADHRHGGLPPKRNQAMTRARKANDKRSQGSKSEKTAVLSHVSKKSSTKHSPVRRESSRRSEKRRTQQQQQQQQQPRPGRIPTSPSATAEGDLVDDASESQANSARVDFKYVQDHMQIPSASDYPDATLEIRNALSLLKPNLLRGVFDTYLRKKLKVIENYEEVTKGWLCELTLDAPGDFQQCVTGVGATKSQAANAAYVYTLSRLHTSGMLAALLSPATMEPMEPRKEQYPGAPPLLFEPAHTASIMHNILAARAPKTIQSGDYEAHADKSATFTLRLDIPGIADASATGRGTNKTMAKRAAWVAMLNRLHTHGALQQILPQVQISPYRPDDHNESKVFIRDESEIELVELDRYTVDQEKNATLDIYNYAARYGAIPQFKTQFAQHVRRRASRAKSRQTVVQASIRLPEHGIHVVTRGKDVATAEAAAALSFKREAEKQQTEQEHPRNPLPGYEFLTTDSAQDFLEWFRRLQSSTTLELELSIVNYAGVSANRARVLVDGSVLGDSTMRAKKAAQSSAYLMAAVAIANNHPEQMAQWVERKKNGEARRPMYSLSMPIDSRISDMMRETLVSARQAGLPDQRETFGAEEATRKTLQSRHRYLSSEARDLACEVHQESLKRFNSDSRLVQLRNTKAGLPMSQYTDQVVDLVSSDVYSIIIGATGSGKTTQVPQIFLDHAIKSGKGGYCDIICTQPRRLAASSVAQRVAAERDETIGTSVGYQVRGEVQLPRFGGSITYCTTGILLEQLKWNTDDIMDNVSHLVIDEVHERDIFVDFLLIILKKAVKARQEAGKKVPHIVLMSATLDQKLFSEYLPNTKDGKTVPCAALSVPGRTFPVTETYLEELVQDITSTHKSEFQSLVRGDKGVSQEYLDAELNFAQSSNGAAPVIIDWKRQYEADADSEGSSPGAQRIESLVPVRLLTAALAHICTKSDDGAILAFLPGLQEISATMEFLVQHPIFGVDFNDTSKFKIMPLHSSIPPDQQKLIFEPSPPGCRKIILATNIAETSVTVPDVKYVVDLGKLREKRYDQVKRITELQTVWESNSNARQRAGRAGRVSQGNYYALFTQQRRQAMSASGQAELLRSDLQETCLSIKAQGFQEPVAEFLADAIEPPPTKAVSLAVENLKSIEAFTPDEELTSLGRILSRLPVHPELGNMVLLGIVFRCLDPMIISSCMASERTLFVKPLGVARSIARRKHEVYAQDDSDHLAYINAFRDLRTQLYEKGQSGTFAYAHDRFLHFGAFKSVDQTTRLVEQALREAGLVDMSHQDRSNKYQLGGDALNANSNNTALLKALTLAGVYPNIAVRRAMTRSPVHRTASEDNVMMHPSSMNASSGKPAVSETDQIYAFSTLARSVSGDSLFIRDSTFVTPLMAFLFGGRVQTETYKTLVMDKWLPFAPAALNTEFVVRLCLEFRKAKDRMLYGAFKEMSNPHTVKTQARAREIFAAGLVNILSASEARRGKMSVGYPESWQKRRSHVSNDFQGRGQSEGGRFANRSDDVRNQASGEGRPLVRFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M3CF66</accession>
    <name>M3CF66_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_149111</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760549.1">
        <property type="nucleotide sequence ID" value="XM_016905348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CF66"/>
    <dbReference type="STRING" id="692275.M3CF66"/>
    <dbReference type="GeneID" id="27902485"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002865_5_1_1"/>
    <dbReference type="OMA" id="SWPTPHF"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF119">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="269"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="572"/>
            <end position="573"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF12428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="667" mass="74682" checksum="F4EFBFFB98F6CB01" modified="2013-05-01" version="1">MTIPEEVDIIVCGGGSCGCVVAGRLANLDHKLQVLLIEAGESNLNNPWVFRPGIFPRNMKLDSKTASFYYSRPSEWLSGRRAIVPAAHILGGGSSINFMMYTRASASDYDDFQAKGWTTKELIPLMKKHETYQRACNNRDLHGFDGPIKVSFGNYTYPIMQDFLRAAESQGIPVTDDLQDLVTGHGAEHWLKWINRDTGRRSDSAHAYIHSTRQHYENLHLAVNTKVDKVIFEGTKAVGVRTVPTKPLSPSENHSRTFRARRQIIVSSGTLSSPLVLQRSGVGDSQKLRKAGVRPIVDLPGVGQNFQDHYLYFSLYRAKPETESFDDFARGDEKVQEKVFNQWQLDGTGPLATNGIEAGVKWRPNQKDLDDMARSPFPEFIKGWDSYFKNKPDKPVMHWAVVAGWFGDHTTVPGTGKFFSMFHFLEYPFSRGFTNIVSPNPYEAPDFDAGFMNDRRDMAPMVWGYIKSRETARRMDAYAGEVATNHPFYAYDSPARCHDMDLATTKAYAGPNHLTAGLVTGSWTIPLPEPSKKPDAAYLNSNQQVVHDDLQYSREDLLAVEEWVKRHTETTWHSLGTCSMGPREGNSIIKHGVVDERLNVHGTTNLKVADLSICPDNVGCNTYSTALLIGEKCAVLTAEDLGYSGRALDMRVPDYQVNREIVGLSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M3CFJ4</accession>
    <name>M3CFJ4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_141487</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760714.1">
        <property type="nucleotide sequence ID" value="XM_016902966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CFJ4"/>
    <dbReference type="GeneID" id="27900103"/>
    <dbReference type="eggNOG" id="ENOG502RFYQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_858341_0_0_1"/>
    <dbReference type="OMA" id="FATKAQQ"/>
    <dbReference type="OrthoDB" id="3648876at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032365" evidence="2">
        <location>
            <begin position="19"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF12593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="324" mass="32718" checksum="382A36702C9266D1" modified="2013-05-01" version="1">MFGLPISLLSLLLVTTSANPITLLAERQTQQQINIQFSVSEAQFRTFENSNTLRSYFRSRGYNYNFNYAQLSQGVALVDGYFAQRASQTSPSSSNNGFPTSGGTPQTFTDSISLLGGPSYTNNSMSAEANLVSVISFSDGDAATAGGAIQRAKSSSSTASSGSSNSTATVSGSPASIDVTSTVTGATDERYVAGNPQDALTAGNCAAAANGASAQSTLITSLTLPINVSSPGQSMSETASSFCEAGVSAKQAGTSGGSGTSVGSTQGTLTNGGVVAVVTCNGQVSRGVPNVVFQVSLQGTFSSSQGFRGTFVGTRTASVAVSCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M3CFL7</accession>
    <name>M3CFL7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_149239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760739.1">
        <property type="nucleotide sequence ID" value="XM_016905436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CFL7"/>
    <dbReference type="STRING" id="692275.M3CFL7"/>
    <dbReference type="GeneID" id="27902573"/>
    <dbReference type="eggNOG" id="ENOG502REA9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036105_0_0_1"/>
    <dbReference type="OMA" id="MKWLEVM"/>
    <dbReference type="OrthoDB" id="5284003at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="597"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF12618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="616" mass="69790" checksum="4B8C8B62E8493A09" modified="2013-05-01" version="1">MATAVATQTETLVARPKEKHKTTLHDLSEELVGLVIERVIRPSDLKNVCRVSKQFHKLAVRFLYRNVSLDLGSDNDNRLSSFLNPRNIGLKHIRQLRLYLAESTDRCNQERQAQFATRMILEFLPEDILEEFSWCPWKTFSAETLLLLYKRQRKMKWLEVMDLDRDILPELKKAVKTTTTMFESTRKLALYPENRATLNLSGFFLEHCKDKVEELIVHCNFSDQGSPDVPNNRELNDSATSPGLLSRSLFASMVPFERCEPLKSLTSLRLHRINLRHCADTWCRALSFHQLEHLRLYHCPGADTLLGQLSKSTHLPKTLKVLELQHRDNSDSETLLALDGFLCLVSGLHDIVIDLENAKALPAAAGIVRHSKTLELLSVHCAGSASHAPTSMNADTENEELVWDAEDVEKICQACKGLEQLSCAWPPTSLIRSPSSEWRRFETCILELRNMVTLHITTWPNNKPSTQLLPRVVYQSLIRELAQRVFEKAVSGKRNPSVSSGADEGDGTAEGTVYGPSDTERPSRLKLIAFGNSDKIYEREDSQNQIIYLNSTAIDAEGRSVPHAVAIGWCLRQYVEPRSEVLDFVLHDYNPPVSDFHAGTGRVRHPPPGWDDEDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M3CGD1</accession>
    <name>M3CGD1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_86207</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760969.1">
        <property type="nucleotide sequence ID" value="XM_016910407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CGD1"/>
    <dbReference type="GeneID" id="27907544"/>
    <dbReference type="HOGENOM" id="CLU_3143949_0_0_1"/>
    <dbReference type="OrthoDB" id="627406at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF12848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="49" mass="5459" checksum="28497E562005BDE3" modified="2013-05-01" version="1">MAEDYVQLLDNTAIHSILRTPKFSYFKGALGALDSTYINAVIPEERQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M3CGY2</accession>
    <name>M3CGY2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyrroline-5-carboxylate reductase</fullName>
            <ecNumber evidence="5">1.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_148457</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-proline + NADP(+) = (S)-1-pyrroline-5-carboxylate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="5"/>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761204.1">
        <property type="nucleotide sequence ID" value="XM_016904942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CGY2"/>
    <dbReference type="STRING" id="692275.M3CGY2"/>
    <dbReference type="GeneID" id="27902079"/>
    <dbReference type="eggNOG" id="KOG3124">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042344_1_1_1"/>
    <dbReference type="OMA" id="VWAVKPQ"/>
    <dbReference type="OrthoDB" id="10263291at2759"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3730.10:FF:000001">
        <property type="entry name" value="Pyrroline-5-carboxylate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.10">
        <property type="entry name" value="ProC C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053790">
        <property type="entry name" value="P5CR-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645:SF0">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00521">
        <property type="entry name" value="P5CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 4 5" id="KW-0521">NADP</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032713" description="Pyrroline-5-carboxylate reductase" evidence="7">
        <location>
            <begin position="28"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="8">
        <location>
            <begin position="2"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase dimerisation" evidence="9">
        <location>
            <begin position="206"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="4"/>
            <end position="9"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="91"/>
            <end position="94"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000193-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF13083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="313" mass="32852" checksum="EE2B553EB9730A52" modified="2013-05-01" version="1">MTILGCGTMGTAILSGILASLVQSAEAMDNDKSLPAERIPSRLPSRFYACVRSARGAKRVHDELDKYNANLHVFENDNVSAVKDSDVVLVACEPHVVDDVLGVAATGMQEALEGKLLISVLGGVSEHRLHQIIQGDSSSSRTSKDSKGTSSSSSSCTIVRAMPNTAAAIRESMTVIVTSNPPLPEETADLVSWIFTRIGQIIYLPESHIDASTALCGSGPAFCALVAESMAAGAIRMGIPRLEAYTMVAQVMRGTTGLLQHGEHPALLRDKVCTPGGGTVAGLQVLEEGAVRGTISRAVEESAKVVGRGGRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M3CHH0</accession>
    <name>M3CHH0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_107280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761359.1">
        <property type="nucleotide sequence ID" value="XM_016900678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CHH0"/>
    <dbReference type="GeneID" id="27897815"/>
    <dbReference type="eggNOG" id="ENOG502R9RG">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_268337_0_0_1"/>
    <dbReference type="OMA" id="QANRVEC"/>
    <dbReference type="OrthoDB" id="3647232at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="731"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1155"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="267"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="486"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="587"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="732"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1164"/>
            <end position="1178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF13238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1224" mass="137007" checksum="839A378D7F0FE2C5" modified="2013-05-01" version="1">MDELPFSKPSSSAHRFAHNDKNGRGWGQLDNSKEEIAVAGNPTPRAQSRSAFTTNRSSKTPSVNLKNQLLNSVKRPGDLPGSIPQSDAAKRQKLPSSQLPQRSNDSSLPVRDTPSGPFHSSSKLSNASAAPKPMKSIFMEISDDSDDDKATEPISRQLSPLRSSLPVAHRILEVNGEAALARSKFLRQQAENAKLADKHFKPPTWPTASIARRQTVKKEQSPPTPSRRSQKSKRKDVRSIARPKPEEVISRELDEEVAPITPLTMSRQRQPQTTKPQRIARETPKTSLFSSEGTDGPSTFTQRLQEVKKEHPLEPEIRSRRPVQHKVELANSVSTNFETEQNKQQRLGFKTAEAASQKLERERQQSLHHARLVVEQQNKKREADERIRRQQEERDRAQRAEGAKARLAELQRRRQQNIDKQRLEYADQQRNRAIDEQLRVSREETRKKKAEVEVEAAARKAKADAELARKKARDDAEKEAARIRRAALAAQAPILDEQARRDRDERIRLKKERAIRNKQTEREEEIEDEDEPHAAPKPKPKGPAATVREARLTEKPAATEDVGNHDNNDGPAAYRPTPHLYAKQPISLHSAAGSNALSSGSRPMQQPSGIKPRVVRDKQRPLGEILFEDAKLLQWRDTGESWSAISTKFAELTGKKRAEDTLRRRYSTVSKALSEARVGSELKRRMVANDEEARMEVNVAVHGEWPIGSTANTNAANTVPIKSVTPQVLEVEPEKASHEKDNKAKRSIDNDPHHQWVQPQKAAPATAMGSSNTLTTGSVPPGLIKGSLGEILPIDALIICWRREGMGWAQVVEKYRAATGIRKSDYRLKLRVDEVEPAVNDAVVFPDELEALSRDAPGARAKVNKKVWKTWPPVPEPVSEQDMAVAKPLDEPAARPTTGGKTITWDIHSKYLEDREAADAELSDVESASEIDEDNPQDSYYYYYRVYRREYTLEDEEDGIGIQDVEWRECNEFENPDEANQAAAAEISQQVQGRPNFQEGRYTLEHNSHNGFQHLTLVNAAVGQLDVIVSPVVRIPEERILPSSKEGWLHNSLYYVKQAITHIKYTVDDVLGETHTETVIREKEVEGTHTSFLDQANLRAVTHFVKLTRPKSVNLDQNSLEQANRVECLLAELRDRADAEVVGESGSGQEIMFRGVLDDDDDGGGGGGSGGGGGGGEGGGKEESVGGQQEKNNKKKKKEKKEKVEVWVVRTRLTGPRNLYKFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M3CHX6</accession>
    <name>M3CHX6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Pre-mRNA-splicing factor SYF2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_148702</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">May be part of a spliceosome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the SYF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761504.1">
        <property type="nucleotide sequence ID" value="XM_016905094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CHX6"/>
    <dbReference type="STRING" id="692275.M3CHX6"/>
    <dbReference type="GeneID" id="27902231"/>
    <dbReference type="eggNOG" id="KOG2609">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051065_0_1_1"/>
    <dbReference type="OMA" id="RRRMHND"/>
    <dbReference type="OrthoDB" id="199717at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013260">
        <property type="entry name" value="mRNA_splic_SYF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13264">
        <property type="entry name" value="GCIP-INTERACTING PROTEIN P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13264:SF5">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SYF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08231">
        <property type="entry name" value="SYF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="77"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF13383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="319" mass="36054" checksum="D8E97FFED0A2F6DD" modified="2013-05-01" version="1">MPVTRKRKGSPGLEETAAESSKRRFAETEVEAEAEAEAEAEAEEEAEAEAEVEAESSSSVNAKEPTATSAADERAARFAALRARNAASRKSNLQDTKHEMQRAAVDPSQLTSLNRRKDIAQHKLLKSEIEEGGQDFERKRAWDWTIEESERWDERLAEKARKRDENQFADYNKEAGKVYERQLGQMAKAGFDERLASYEQNKRDAINRAVASGGLELVETQDGELIAVDKDGTFYSTNDSAAFTAGKPSKEAVDRLVTDIKKAEEVRQKKRRDRGRPDEDGQDITFINEKNKQFNMKLARFYNKYTADIRESFERGTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M3CIL3</accession>
    <name>M3CIL3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_41767</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761774.1">
        <property type="nucleotide sequence ID" value="XM_016908844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CIL3"/>
    <dbReference type="STRING" id="692275.M3CIL3"/>
    <dbReference type="GeneID" id="27905981"/>
    <dbReference type="eggNOG" id="KOG0508">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064330_1_0_1"/>
    <dbReference type="OMA" id="WDINEPV"/>
    <dbReference type="OrthoDB" id="3650438at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="153"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF13653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="219" mass="24448" checksum="F31BFB66314AEAD9" modified="2013-05-01" version="1" fragment="single">LLEQGVPVNSSHVQSATEERNTEVLALYFNGHWDINKEIEWAVPPALAYAVDDAALTQWFLSRGADPNAQCLLDITPLSAAVQYAPMSVLKLLFEHGGSIAFGQLLNYAAWRELDDRVDVVMFLLAKGAPINNIMYQNRMDCYRQREAFALGTALHDAAAIGSIDVVKTLVDAGAELRIKDSRGETPLQRAERNNHFDVIQYLQPLVERERSTVTTVHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M3CJH1</accession>
    <name>M3CJH1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I and III subunit RPAC1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">DNA-directed RNA polymerases I and III 40 kDa polypeptide</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_149060</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762059.1">
        <property type="nucleotide sequence ID" value="XM_016905312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CJH1"/>
    <dbReference type="STRING" id="692275.M3CJH1"/>
    <dbReference type="GeneID" id="27902449"/>
    <dbReference type="eggNOG" id="KOG1521">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038421_0_1_1"/>
    <dbReference type="OMA" id="KKKCRAF"/>
    <dbReference type="OrthoDB" id="270173at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006363">
        <property type="term" value="P:termination of RNA polymerase I transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07032">
        <property type="entry name" value="RNAP_I_II_AC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.120.12:FF:000003">
        <property type="entry name" value="Dna-directed rna polymerases i and iii subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.10:FF:000005">
        <property type="entry name" value="Dna-directed rna polymerases i and iii subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00320">
        <property type="entry name" value="RNApol_arch_Rpo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022842">
        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033901">
        <property type="entry name" value="RNAPI/III_AC40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050518">
        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF13">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="8">
        <location>
            <begin position="65"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00081520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF13938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="393" mass="44367" checksum="2114FD92E22C9857" modified="2013-05-01" version="1">MPSWAPLTKEQLEQRRIVNINAETVSNVASTDLPGHYGPKQDDTWNLDRFRQNLRIQFHQNKPLDAAFSLVGVDASVANALRRIALAELPTLAIENVYMYDNTSIIQDEVLAHRMGLIPLKGGKEGLRWMQWFKKTPPESDHAAYAQFMAEQEEEGADRSASTPSDLNTVVLNLKVECRWKTVEEDGVDGKKLAREGSTDPTEKYVNSNVYAHQITFEPQGQRQPEFFSGENAIRPVNPDILIAKLRPGQRIHMTMHCVKGIGADHAKFSPVATASYRLLPDIKITQPIVGADAKAFQKCFPKGVIGLEEDPESGEKRAVVKDPFKDTVSRECLRYDEFKDKVKLGRIRDHFIFSMESSGQFDSDELFIDSIRVLKQKATTFKKHLDALEEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>M3CN21</accession>
    <name>M3CN21_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Nitrate reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">SEPMUDRAFT_59767</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 17">Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>nitrite + NADP(+) + H2O = nitrate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19061"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.7.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
        <text evidence="18">Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the nitrate reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763319.1">
        <property type="nucleotide sequence ID" value="XM_016909505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CN21"/>
    <dbReference type="STRING" id="692275.M3CN21"/>
    <dbReference type="GeneID" id="27906642"/>
    <dbReference type="eggNOG" id="KOG0534">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0535">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003827_4_0_1"/>
    <dbReference type="OMA" id="KAMMPDY"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050464">
        <property type="term" value="F:nitrate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008482">
        <property type="term" value="F:sulfite oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006809">
        <property type="term" value="P:nitric oxide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.650:FF:000001">
        <property type="entry name" value="Nitrate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000016">
        <property type="entry name" value="Nitrate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.420.10:FF:000005">
        <property type="entry name" value="Nitrate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="entry name" value="Oxidoreductase, molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005066">
        <property type="entry name" value="MoCF_OxRdtse_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008335">
        <property type="entry name" value="Mopterin_OxRdtase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012137">
        <property type="entry name" value="Nitr_rd_NADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022407">
        <property type="entry name" value="OxRdtase_Mopterin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372:SF7">
        <property type="entry name" value="SULFITE OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372">
        <property type="entry name" value="SULFITE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03404">
        <property type="entry name" value="Mo-co_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000233">
        <property type="entry name" value="Nitr_rd_NADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00407">
        <property type="entry name" value="EUMOPTERIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="Oxidoreductase molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00559">
        <property type="entry name" value="MOLYBDOPTERIN_EUK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="9 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 18" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="14 17" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="20">
        <location>
            <begin position="528"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="21">
        <location>
            <begin position="630"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR000233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000233-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EMF15198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="906" mass="101092" checksum="165B25BE1779D06F" modified="2013-05-01" version="1">MAESQLTAEDKHMRRIPADLPPTPPDSQSESSASDKADDDSIQGGDVNFPLPPKSAAPTEVLEIDKKTPDSWLPRDPRLIRLTGVHPFNVEAPLSDLYNEGFLTSPELFYVRNHGHVPQVEDDAIPNWTFSIEGMVENPITMTLADLLEQYEQHTYPITLVCAGNRRKEQNVVRKTKGFSWGAAGVSTALWTGVVLGDVLRKAKPKRGAKYVCMEGADKLPNGYYGTSVKLNWAMDENKGMMLAHKMNGEMLRPDHGKPLRVVIPGQIGGRSVKWLKKLIITAEPSDNWYHIYDNRVLPTMVSPEESANNPKWWIDERYAIYDLSTNSALAYPAHEEQLGLVGAPDKYRVKGYAYGGGGRRVTRVEISLDKGKTWRLANIDYAEDRYREASPRKLYGGTVDLDWREASFCWCFWNLDIAVSELADSKDILVRAMDESMNLQPRDMYWSVLGMMNNPWYRVTIAKEGDYLRFEHPTQPALMPGGWMERVKKSGGNLTNGYWGEQIGGENAEEPVTEAAQEVKMTRDDVKREITIDDLRKHDNEAAPWFVVNGEVFDGTAFMKDHPGGASSIISAAGLDSTDEFMAIHSETAKSMMPSYHIGTLDSTGRAALAGETIQEDTKSTSPTFLDPRTWKKAILTSKKTISWDTRIFTFQLDHDTQTLGLPIGQHLMMRLRDPVTREAIIRSYTPISSPSQCGTMEILVKIYFARPAASGPSAAGSQAEGGGKMSLALDSLPLGHFVDFKGPIGKFTYLGPGLVSLNSQPPPPLSLIKTFYMICAGSGITPIFQVLRSILLNPSDSTKCLVLDGNRLEEDILCKSQLDSFAQNYPEKLQLVYTLTQAGEGWEGRRGRISRELLGEFVGERRNEEEGRRDGEAMVLICGPEALEKSCHTALRELGWRDEELMFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M3CQT6</accession>
    <name>M3CQT6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS glucose transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_131597</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF16038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764159.1">
        <property type="nucleotide sequence ID" value="XM_016902436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CQT6"/>
    <dbReference type="GeneID" id="27899573"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_12_1"/>
    <dbReference type="OMA" id="VTCVLVY"/>
    <dbReference type="OrthoDB" id="4142200at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF7">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="453"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="10"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF16038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="558" mass="61556" checksum="B52B99A9BADC8D49" modified="2013-05-01" version="1">MKQYGNVYLIAAISIIGGGLFGFDISSMSAIIATRPYLCYFNQGPNGPGFNDSDTCSGPRTSVQGGITASMAGGSWLASLFSGMISDRLGRKSAIQIGAVIWIIGCIIVSAAQNIPMLIVGRIINGFCVGICSAQVPVYITEIAPPTKRGRLVGAQQWAITWGIMIMFYISYGCSFINGNAAFRVPWALQMIPAIILFFGMIVLPESPRWLASKDRWEECEQVLILTHGKGDPHSPWVAREFQEIREWIDIERASAQVRYIDLFSAKYINRTHIGLFTQIWSQLTGMNVMMYYITYVFAMAGLTGNTLLVSSSIQYVINVVMTIPGLIWIDRVGRRPILLLGSTLMATWLFANAGILAVYGTDPGPNGVGGIKEASVQVSGAASKAIIACSYLFVASYAPTWGPVSWIYPPELYPNHLRGKAVALATSGNWAFNFALGYFVPPAFVTIKWKTYLVFACFCLAMTVHVFFLFPETAGKPLEEVTEMFESYETNKNESEMQRKGGIKYVGIPAWRTKSEFGRQMRRERGEVEVEEELGGGEKGELERREVVRFGGKEGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M3CUZ2</accession>
    <name>M3CUZ2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="10">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_152296</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>feruloyl-polysaccharide + H2O = ferulate + polysaccharide.</text>
            <dbReference type="EC" id="3.1.1.73"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the tannase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="10"/>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF07967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756088.1">
        <property type="nucleotide sequence ID" value="XM_016907358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CUZ2"/>
    <dbReference type="GeneID" id="27904495"/>
    <dbReference type="eggNOG" id="ENOG502QPXZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014819_1_0_1"/>
    <dbReference type="OMA" id="AWFPREY"/>
    <dbReference type="OrthoDB" id="3039123at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF15">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005140309" description="Carboxylic ester hydrolase" evidence="10">
        <location>
            <begin position="23"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF07967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="528" mass="56584" checksum="792EFE6774D81496" modified="2013-05-01" version="1">MDKISLGFSLAAGLSLISSAGAQQVIQDPASACSSIASTFTYPNATITSAEHVPAGTILDSGLSCNQTSTVPADICRVGFNVSTSARSGIVAEAWLPVNWTGRFLSTGNGGLNGCVKYEDLAYGSESGFAVVGSNNGHDGERGTAFYQNEDVVEDFAWRSIYTETVVGKAMAKAYYSKELTKSYYIGCSTGGRQGFKMAQSYPELFDGILAGAPAIAFNNLTAWSGHFLLITGSPDSETYLTPEKWSLVHDDILKQCDGLDGVEDGILEDPNLCHYKPVSLQCASDATNTSACLTPVQVTTVTNIFAPYHGEQGALIYPRIQPGAEIIGALINFNGQIAPYTEDWFRFAILQDPNWDATTLNSSTAALAAAINPSNIQTWEGDLSAFQNKGGKLLTYHGLMDGVISSDNSPRYYEHVSTTMGLAPSELDSFYRFFRISGLAHCTGGDGAWNIGQATGGGVGAQKNALQRIIDWVEKGDAPETVTGVKYVEGDMTKGVDYERNHCKYPLRNKFVGPGSYKEVDAWECVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>M3CWC0</accession>
    <name>M3CWC0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_111768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756538.1">
        <property type="nucleotide sequence ID" value="XM_016900935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CWC0"/>
    <dbReference type="GeneID" id="27898072"/>
    <dbReference type="HOGENOM" id="CLU_1129675_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF08417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="246" mass="27668" checksum="C3D3B2D8358674E1" modified="2013-05-01" version="1">MPKIGLASSLPNRISFGSSLSFLIIARLKIRVRFALLAARTGPFLDRNHGFSTFEFVTERASLDAFVVTTLDSNLRKPQSYLQRTFGIDVLSGTTRLSRSALAPPKTRQACSQGSPMTDLSPIAPAVQGEEYPPPQALWRLKSASAAMNKADKGDTGLDDEMTWLKRYIIILRKSRMVSQIICKTSPLPLHHSQHKPHSTSIDFFSYIGTEHYAKRIRPQMLTPTDFDLEKDDRADPFYWICFTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M3CXU2</accession>
    <name>M3CXU2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_159372</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756607.1">
        <property type="nucleotide sequence ID" value="XM_016907841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CXU2"/>
    <dbReference type="STRING" id="692275.M3CXU2"/>
    <dbReference type="GeneID" id="27904978"/>
    <dbReference type="eggNOG" id="ENOG502SKSW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020425_3_0_1"/>
    <dbReference type="OMA" id="WANHTEL"/>
    <dbReference type="OrthoDB" id="422736at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22997">
        <property type="entry name" value="GT_LH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36587">
        <property type="entry name" value="EXPRESSION SITE-ASSOCIATED GENE 3 (ESAG3)-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36587:SF2">
        <property type="entry name" value="EXPRESSION SITE-ASSOCIATED GENE 3 (ESAG3)-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF08486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="624" mass="70762" checksum="085EAC64F31287C2" modified="2013-05-01" version="1">MTVRQRSWSSAAADAASRKVAEAEAEAEAEAEAEAEAAAAAGQSTSASIPLIPQDAAVLLHRIGTSASPHEDKVPRTGPKAIVMLQGKPLFFLILTWICFVLYILHPSSEPLIAGTSTTESSGPLDVSRARQKHTATSKNPPANLHLVVPASKGDANLCKVMVSAGILGYPDPVIVNWGEDFDDPKFVEGGSHLAKVTGITRYLNYLNSSMDNDLMLMVDGYDIWLQLRPQTLIDRYFSINKRADERIARELGNAASEHNIHQEVIFGCQKRCWPWTQDDPPCYAVPFSDLPEDIYGPETDTDVGNIENPFIKYRPRYINSGVVIGTVKALRKMFVQALELLTNDPFEANMGSDQYIFSHILGDQEVWREALRQDSRNNLQKLREKFKGGYEPLHPFNPSHVEEVRKKAARRPDKNFEFGIGLDYRMEIGLNTVFSEDDTAWLHWANHTELAAAEERENISPTHPHGVTSQNLSSDITDTVPPFWTFNHEPKFPRWKKWTEIPLFTNIWSGIVPTVIHHNAHRDGLKALRETWWNQTWYAGHTRVLYDAHIWEPVIPVAYSGKEEADLREYWPGERWKGGGRTGPKEIYEPWENRWVRFDDICRPFHEEVFRDGLGEWVLPDVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M3CXY5</accession>
    <name>M3CXY5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Vacuolar fusion protein MON1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_52655</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">In complex with CCZ1, is required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis. The MON1-CCZ1 complex acts at the fusion of vesicles with the vacuole, through its regulation of the SNARE complex during the coordinated priming and docking stages of fusion, and particularly at the stage of tethering/docking.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endosome</location>
            <location evidence="4">Multivesicular body membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 4">Prevacuolar compartment membrane</location>
            <topology evidence="1 4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Vacuole membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MON1/SAND family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757038.1">
        <property type="nucleotide sequence ID" value="XM_016909237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CXY5"/>
    <dbReference type="STRING" id="692275.M3CXY5"/>
    <dbReference type="GeneID" id="27906374"/>
    <dbReference type="eggNOG" id="KOG0997">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014574_3_0_1"/>
    <dbReference type="OMA" id="QQPFNAK"/>
    <dbReference type="OrthoDB" id="272411at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035658">
        <property type="term" value="C:Mon1-Ccz1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032585">
        <property type="term" value="C:multivesicular body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043972">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043971">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043970">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004353">
        <property type="entry name" value="Mon1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13027">
        <property type="entry name" value="SAND PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13027:SF7">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN MON1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19036">
        <property type="entry name" value="Fuz_longin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19037">
        <property type="entry name" value="Fuz_longin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19038">
        <property type="entry name" value="Fuz_longin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01546">
        <property type="entry name" value="YEAST73DUF"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="FUZ/MON1/HPS1 first Longin" evidence="5">
        <location>
            <begin position="30"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="FUZ/MON1/HPS1 second Longin" evidence="6">
        <location>
            <begin position="192"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="FUZ/MON1/HPS1 third Longin" evidence="7">
        <location>
            <begin position="339"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF19037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF19038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF08917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="450" mass="50161" checksum="DB14C0FE6D841978" modified="2013-05-01" version="1" fragment="single">IRHEFDDVQLTAVDGATEEDVLSNWKSKLKHFFILSASGKPIYSRHGNDQMISHYVGVAQTLISFYQGQQDSLKSFTAGDTRFVMLAKGPLNLVAISRLAESEAQLRTQLESLYMQILSTLTLPSMERMFSNRPSTDLRRPLQGTDVLLDGLADGFTRGSPSTLLSALECLRLRKTHRRAINDILLKARSPNLLYGLIVAAGRLVSVVRPKKHSLHPGDLHLIFNMLFEAGSVKANGGENWIPLCLPGFNNTGFLYMYVSFFTASENRAEAVEERSAGSENDDELAIVLISANKEAFFELRKMRDDLVAQLESSGSMSNIKTATRKGHATCSEIVPGTSLRHFLYKSRGNVQFVMPSFQPHFSGVMGRRRLLTLYAHLQESIHSRTARLKVQHSIAADSTSLAWETPLFELYCVAGPQTSRAALVQGANRVVQWIRREEERVFIIGGAVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M3CYB2</accession>
    <name>M3CYB2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NADH-ubiquinone oxidoreductase 213 kDa subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_151658</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756797.1">
        <property type="nucleotide sequence ID" value="XM_016906962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CYB2"/>
    <dbReference type="STRING" id="692275.M3CYB2"/>
    <dbReference type="GeneID" id="27904099"/>
    <dbReference type="eggNOG" id="ENOG502S81D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088319_0_0_1"/>
    <dbReference type="OMA" id="TMMNLRE"/>
    <dbReference type="OrthoDB" id="1913277at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039205">
        <property type="entry name" value="NDUFA11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21382:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21382">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0830">Ubiquinone</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF08676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="212" mass="22377" checksum="19EFEEB98E27A7E6" modified="2013-05-01" version="1">MEEAGHIAAQALTGNHTEEDSYHPRDAVGSTIKATLTTGTGGAFVSAIQNTLTKQNVGAWGVFTRTGGTVATFAAMGGAYEFFKSASANLRQKEDTYNYAIGGAFAGAMLGLRFRSAPAVLGYGTATAVIIAAFQYTGGHMLGAALDPDVDEVARKEYMRKNRRRDIGEIVNELGEGRGIVAPGYAERRAARLKEAYGIDVVHSPTVPGQSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M3CYM9</accession>
    <name>M3CYM9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_120680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756897.1">
        <property type="nucleotide sequence ID" value="XM_016901627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CYM9"/>
    <dbReference type="GeneID" id="27898764"/>
    <dbReference type="eggNOG" id="ENOG502S71Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138679_1_0_1"/>
    <dbReference type="OMA" id="LKHWPTD"/>
    <dbReference type="OrthoDB" id="2107880at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061671">
        <property type="term" value="C:Cbp3p-Cbp6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037653">
        <property type="entry name" value="Cbp6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28250">
        <property type="entry name" value="CYTOCHROME B PRE-MRNA-PROCESSING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28250:SF1">
        <property type="entry name" value="CYTOCHROME B PRE-MRNA-PROCESSING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20180">
        <property type="entry name" value="UQCC2_CBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF08776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="131" mass="15238" checksum="04EA60BCDD18FCA6" modified="2013-05-01" version="1">MSRQHIVSHYTRLLARWPKDALRPEKTFQQIILEPRLQAAPTASPAGVTSEAISSPSATSSYVRNENNEVNAAYLLLENSFSKQFRPGKRLMEPMSNPKHYENLRRELEELPNRSLWGNWLQRMKSMVRMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M3CZ54</accession>
    <name>M3CZ54_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">mRNA 3'-end-processing protein RNA14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_93243</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 4">Component of the cleavage factor IA (CFIA) complex, which is involved in the endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="4">Nucleus and/or cytoplasm.</text>
    </comment>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757057.1">
        <property type="nucleotide sequence ID" value="XM_016910606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CZ54"/>
    <dbReference type="STRING" id="692275.M3CZ54"/>
    <dbReference type="GeneID" id="27907743"/>
    <dbReference type="eggNOG" id="KOG1914">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007630_1_1_1"/>
    <dbReference type="OMA" id="VQLWSVY"/>
    <dbReference type="OrthoDB" id="26282at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180010">
        <property type="term" value="P:co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045243">
        <property type="entry name" value="Rna14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008847">
        <property type="entry name" value="Suf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980:SF0">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980">
        <property type="entry name" value="RNA CLEAVAGE STIMULATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05843">
        <property type="entry name" value="Suf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Suppressor of forked" evidence="6">
        <location>
            <begin position="231"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="175"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="624"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="890"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="53"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="213"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="228"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="628"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="644"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU369035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF08936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1050" mass="115788" checksum="DE7BF24B3983C605" modified="2013-05-01" version="1">MAAEYDPSEPQTYDDGADHGEDNYDPTGYGNYNGQENEGHEEADDEDDDYDPSSVNYGENTENTTPAQSVPHTPAQTDQPAQKMQHKVAGFIVEESDDEQEAGAPPAPSQANGDAGEHSGLGAVAQSEAQDVSLHSAPHVDTAAEGASLNGFTVPVSASTTSSVAPELTVQSLAPVPAPPEATEGKTASTAPSAQPTPQPVQQSIAPTPQPPVQQASAPAVQGPPARLPHDKVGQLEDRIKDDPKGDTDAWFTLIDHYISKEQFDNARSVYSRFSKVFPTSVQLWLRRIQLENDLDQREFMAHLLTQALNTVPNVALWKFYLDHIRRILPVSGEQGPANRAQIMEAFKMTLDQSGIDPDAGDLWREYVDFVKDGPGNVGGQGWQDLQKVDLLRKAYQQATKLPHGELVKLWKEYEAFEMNIHKQTGRKHIQEQSPHYMQARTARMQLEQKLQRLDRTSLPRLPPIYGCAGEDDFGEQVERWRAWIHWERDEDPLVYKGSEDAEWRKRVVYTYKQATMALRFYPEIWFEAASWCFSTGIDAIIKEGEDFLDSGMTANPESVLLAMMKADRVESSLESGNTDEVLLRNGERLNKPFEDVHTPLYALRNKIMEKDKAAKAQVEAHFASLPAEDENANEQEDDDDDEPKEKPKTRAEQKQEQLDAIKKSSAAHLDMLKRTISYVWVAKMRAFRRVQGQGKPPKKGAEAGKEIKGFRGIFGEARPRGPLSSDVYIASALMEWQCYRDPSAVKIFERGMKLFPTDDAFILEYIKHLISIGDITNARVVFESTIPKIMATADITPEQKQDRCRPLIGYMHDFESKYGDLAQIHKIEKKMAEIYPQEPEIARFAHRLELPTFDAIHAQLILSPTQAQPKPIASLPPGIAAQHIMGGQLAPSIEGPSSPKMGGAPEILLGPNGPYVASPKRPHDSDDDGPSRKFMRGESPLKGAAGVRLAATTSGAGKGGFATKTFVPVNGVAPPAGVSAPPPGLPPMPVGPPPLPVQVLGVLSALPPSSVYNSVQFDTVKLVQYLQRVPVENTRAEFMNGSLKLAQRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M3D0P8</accession>
    <name>M3D0P8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AA_permease-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_150102</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759204.1">
        <property type="nucleotide sequence ID" value="XM_016905963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D0P8"/>
    <dbReference type="STRING" id="692275.M3D0P8"/>
    <dbReference type="GeneID" id="27903100"/>
    <dbReference type="eggNOG" id="KOG1286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_12_1_1"/>
    <dbReference type="OMA" id="NTIIHYW"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF15">
        <property type="entry name" value="GENERAL AMINO ACID PERMEASE AGP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="424"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="458"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="503"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="536"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="89"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF11083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="601" mass="66319" checksum="567B3FA786A744F8" modified="2013-05-01" version="1">MSSPFKQRFPFKRTDTSGGNGGGDDGVGVENEKNHSASKKQDYGITTEIPPKYDGSDVERRMSTSAASIASHNISGIHDNTHRQLKPRHIQLIGIGGTIGTALYVQIGRGLLNGGPASLFIAFTFWCTVVLAVTLCLAEMVTYLPISSPFIRFAGRYVDEAFGFAAGWNFFIFEAILVPFEITACDVIIHYWSTALPTWALVLIIIILYGAINLVNVKWYGEVEFWAALGKVLLIIGLIIFTFVTMLGGNPLGDRFGFRYWNSPGAFKPLYTEVSGISGKPNLAYFLGFLQCLIQASFVIAGPDYVSMSAGEAENPRIVLPKAYNAVFYRLTTFFVLGALCVGILVPYNDPELTAAFSSGLPGAAASPYVVAMNRLQIGVLPHIVNALVLASAFSAGNSYMYCASRSLFGLALEGKAPRIFTKTNRIGVPYTCVLAVLAICLLAFLSVSSGSAKVLGWFVNLITASQLINFAIMCFTFLMWYRALHAQGINRETLPYKAWGQPYVAVYGLVWTGVMAIVGGYTVFLPGFWEVQTFLFSYFMVFLFPVLFVGWKVVKRTRWYAPEEVDLKGEREEIEEYTRTFIPQPYKNSADKWFNKMFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M3D123</accession>
    <name>M3D123_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1680-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_110577</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758314.1">
        <property type="nucleotide sequence ID" value="XM_016900851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D123"/>
    <dbReference type="STRING" id="692275.M3D123"/>
    <dbReference type="GeneID" id="27897988"/>
    <dbReference type="eggNOG" id="ENOG502QVKK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016354_1_0_1"/>
    <dbReference type="OMA" id="WERGPYW"/>
    <dbReference type="OrthoDB" id="5358475at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF10193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="720" mass="80770" checksum="A838B365A0A2C536" modified="2013-05-01" version="1">MHEFIAFDASPAVVTPTPLVPFVYAEIPLGNITPNGWLRAEMETEANGLAGHLYDFYSFVHDATWLGGSAEYSNLNEAFPYWLNGIVPLAYTLNDQRLKDQVHEAMDYLFAHMIADDGWIGPEQGGMRLLWARTLIFFAWTNLVEANKTYEEPVVTAMHDFNLLMHSMLKNNGTGLVEQENSEIDGGYFFWFLSRVAEMIVSLQWLYDKYPRGQEQILRENMQMLHEYGWKWEAWFTNSSYAFDDLYNLPDQFSDDHFHFLHGVNVGEGLKAPAVIRRFTYNDSLVQTTRDGVQWTMKYHGAPSGTILADEREDGVSPWYGSELCTAVEVMFSQSYNFRALGESFYADGSELAAYNALPGGMTDDWWAHVYVSQPNQPYAKNLTWSPFSNTDTMSQTYGLEPDYPCCTVNHPQGLPKFAQAAFVTLGDNGLVHALLSPVSVTTTIGGGLVTVECITNYPFEDVLVYKIQAQKSFDLHIRQPTWATKATLSNENAMKESTYDDTTGLHKTSISSGLSTVVYTIETSIRTEPRANDTIAVYRGALLYAFEVAAEISSTGPHNYRNKTLYRSDYAPSQAKDYIMLNATEWNIAIDPSTLVYHHHHHPSSRRESKVRNHIAKQDPRGSQLPLLGGGGGDDNDMMTIGTIEPLPTPIFASGNPPMYMTVRACLIDWPLLNGTVPGWPSALSERKCLGDVFDAKLVPYGSAKLRMSELPVIDLKGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M3D1E4</accession>
    <name>M3D1E4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_12689</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758429.1">
        <property type="nucleotide sequence ID" value="XM_016902109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D1E4"/>
    <dbReference type="STRING" id="692275.M3D1E4"/>
    <dbReference type="GeneID" id="27899246"/>
    <dbReference type="eggNOG" id="KOG2177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115229_0_0_1"/>
    <dbReference type="OMA" id="CGARIEY"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327">
        <property type="entry name" value="RING FINGER PROTEIN 127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327:SF51">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR OF YEAST FORM ADHERENCE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="26"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF10308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="160" mass="18566" checksum="DECBD0C62717F7AA" modified="2013-05-01" version="1" fragment="single">DEHCHHEQSLRALHTDMDAMRHLITCKMCYRFLYEPYGLSCGHTYCYSCLAQWMCNSKTCPDCRAKVKEQPTPTFLVREMVRVFVAKDELLPDGETKEEHAKMAKEEAELVAKDRANEDVALGGLFRGRFRKGSRFHPVNAFRDESDNVWRCPACMNEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M3D248</accession>
    <name>M3D248_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_109621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759689.1">
        <property type="nucleotide sequence ID" value="XM_016900793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D248"/>
    <dbReference type="GeneID" id="27897930"/>
    <dbReference type="HOGENOM" id="CLU_719945_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF11568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="384" mass="42807" checksum="367859D2ECA485E0" modified="2013-05-01" version="1">MRRNAQVNALSDPLEDSPSRLPLPQNPVGEARVHTSRHDSRQWSMSSASKSRQPSLVVGSSTQSFTLSAGNALDQTASGITEETLLGEPDGADQAVETARTAREQSERQRVERARGFTTPDTQRETIVESEDRGYAPGPDFMYLSSGSSGREKPEPKRSEIDAEAEERVTQSHHRLNEVLSAPARSRRRNSETCASATPRITTRIRSRSLCLPRPSAERDPWTHDFQLRDVLWLGEHPEAAVLIENRHTPSERPNTLLKSSVDRIDRPLSLAPMRPPPLPPRSRGKSIQTQHDGSEPQLGVPTSSNVSQEGVSERPSMKMARSSRTVVNGDEKGPDQLLTNRPKDSRFIEHIPENEERLRGLGVGLERHKGGGGWFQKWKRRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M3D2N7</accession>
    <name>M3D2N7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fumble</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_47525</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759528.1">
        <property type="nucleotide sequence ID" value="XM_016909039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D2N7"/>
    <dbReference type="STRING" id="692275.M3D2N7"/>
    <dbReference type="GeneID" id="27906176"/>
    <dbReference type="eggNOG" id="KOG2201">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011154_3_1_1"/>
    <dbReference type="OMA" id="WSKGAKQ"/>
    <dbReference type="OrthoDB" id="498611at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd24123">
        <property type="entry name" value="ASKHA_NBD_PanK-II_Pank4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000115">
        <property type="entry name" value="Pantothenate kinase PanK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.510:FF:000005">
        <property type="entry name" value="Probable pantothenate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004567">
        <property type="entry name" value="Type_II_PanK"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00555">
        <property type="entry name" value="panK_eukar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280:SF20">
        <property type="entry name" value="4'-PHOSPHOPANTETHEINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280">
        <property type="entry name" value="PANTOTHENATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03630">
        <property type="entry name" value="Fumble"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF11407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="444" mass="48891" checksum="A7577EE461A63274" modified="2013-05-01" version="1">MQHAIAQPGSIKINVTGASIIDHEDEDSSPDRSPTSSHADHSESDGELSYQHHKRDIRLPNHTAVVSHVAADIGGSLAKVVYFTRENEHESTSGGRLSFLSFETEKIDDCIDYLRTLQTKHQRANGMDNSTKLSIMATGGGAYKFYDKIRSTLGVEVEREDEMECLIKGLDFFITQIPNEVFTYDDTSEGGPMHFQEPKSDVYPYLLVNIGSGVSMIKVSGPSEYQRIGGTSLGGGTLWGLLSLLTGARNFDDMLDMADKGDNGAVDLLVGDIYGEGMGYEKIGLSEKTIASSFGKVLKRKREAERLAEDGNGCSNEKLTRPKLKTENGVRDDSVGSGLIGDGRMFKPEDISRSLLYAISNNIGQIAFLQSERHDLKRIYFGGSFIRGHQQTIHTLSFAINFWSKGSKQAFFLRHEGYLGAVGAFVKRRPANWGRSRSVEPNGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M3D5L6</accession>
    <name>M3D5L6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">methylcrotonoyl-CoA carboxylase</fullName>
            <ecNumber evidence="3">6.4.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">3-methylcrotonyl-CoA carboxylase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_148728</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-methylbut-2-enoyl-CoA + hydrogencarbonate + ATP = 3-methyl-(2E)-glutaconyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13589"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57344"/>
            <dbReference type="ChEBI" id="CHEBI:57346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AccD/PCCB family.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.4" evidence="3"/>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761556.1">
        <property type="nucleotide sequence ID" value="XM_016905110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D5L6"/>
    <dbReference type="STRING" id="692275.M3D5L6"/>
    <dbReference type="GeneID" id="27902247"/>
    <dbReference type="eggNOG" id="KOG0540">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018822_0_1_1"/>
    <dbReference type="OMA" id="GATTHCE"/>
    <dbReference type="OrthoDB" id="5358475at2759"/>
    <dbReference type="UniPathway" id="UPA00363">
        <property type="reaction ID" value="UER00861"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905202">
        <property type="term" value="C:methylcrotonoyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004485">
        <property type="term" value="F:methylcrotonoyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000004">
        <property type="entry name" value="Methylcrotonoyl-CoA carboxylase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000007">
        <property type="entry name" value="Methylcrotonoyl-CoA carboxylase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045190">
        <property type="entry name" value="MCCB/AccD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855">
        <property type="entry name" value="ACETYL, PROPIONYL, PYRUVATE, AND GLUTACONYL CARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855:SF13">
        <property type="entry name" value="METHYLCROTONOYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="7">
        <location>
            <begin position="81"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="8">
        <location>
            <begin position="339"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00052347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF13435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="582" mass="62587" checksum="C74B05EEF6EB2C9E" modified="2013-05-01" version="1">MASLLLPLPARALLHHVPRRQRLLHHPLPLRLVLQPVQCHYLSQRRKASTYTSPHHAAQLSVVQTAVDPSSNAFRDNAAAMAEYMHTLTALHESAAKGGPEKSRQKHVERGKLLVRDRITALVDPGTSFLELSALAGHEMYPGEDVPGGGIVTGIGTVEGVQCMILANDSTVKGGSYYPITIKKHLRAQEIAQQNRLPCVYLVDSGGANLPHQANVFPDRDHFGRFFYNQANMSAQGIPQISVVMGSCTAGGAYVPSMSDESIIVKGQGTIFLAGPPLVKAATGEEVSAEDLGGGKLHSEVSGVTDYLAEDDTHALVLARRSIANLNYPKSPNPARKETFQEPLYDVEELGGIVGTNLKQSINMHEVIARIVDGSEFSEFKPSYGKTLLTGFASIYGHPVGIIANNGILFSESSLKGAHFIQLCCQRHIPLIFLQNISGFMVGQDAEKGGIAKNGAKLVTAVACAQVPKFTVLVGSSAGAGNYGMCGRAYSPNFLWSWPSAKTSVMGAEQLSSVMAAVGKTVDPELKKRIERESEVTFGTARLWDDGVIPPSHTRRVLGMGLQAAMTGSVEKKETKFGVFRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M3D5N6</accession>
    <name>M3D5N6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycosyl transferase CAP10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_148744</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761581.1">
        <property type="nucleotide sequence ID" value="XM_016905123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D5N6"/>
    <dbReference type="GeneID" id="27902260"/>
    <dbReference type="eggNOG" id="KOG2458">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028539_2_1_1"/>
    <dbReference type="OMA" id="KYLTRAA"/>
    <dbReference type="OrthoDB" id="202415at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF107">
        <property type="entry name" value="GLYCOSYL TRANSFERASE CAP10 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032328" description="Glycosyl transferase CAP10 domain-containing protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="2">
        <location>
            <begin position="151"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF13460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="432" mass="50313" checksum="212B1C40D130510C" modified="2013-05-01" version="1">MVLRPWRFACFLAATFLAIVLLRERSWSTTTSRWTESSFASDGADQEIDLDDIEQLDGLTAAECTAHFPDLYAEVDRAVNYWKDQDHLITPETVNVSWQQDGALRFLIHGNELRILEDRQSSDNWRYHERTVGQMSLIQRAIDSATAGGEMLPTIEASIAFMDKVQPYSKLDNHSLWMVGRLKIEPRHDRLWLMPNFDFWYDRGFGTYREARRRAMSYDAPFSDKIQKLVWRGSEWVQRDVRGSLLKVTEKKPWADVLRTDLDDTAEKKRRKMKPAEMCKYAALAHTEGISYSGRLEFILLCNSLPVVHDLNWIVWYSHLLQPDGPRQNYIPVHRNFSNLETQMTHYLEHPDQAETIIANSLNTFRNKYLTRAAQSCYIRRLIQGYSQVSFEPDPYRSSKEGGSTTALRGRSFEKYLNAPKTGDYEDDDVWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M3D6F4</accession>
    <name>M3D6F4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_148731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761560.1">
        <property type="nucleotide sequence ID" value="XM_016905113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D6F4"/>
    <dbReference type="GeneID" id="27902250"/>
    <dbReference type="HOGENOM" id="CLU_1653224_0_0_1"/>
    <dbReference type="OrthoDB" id="3641562at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032265" evidence="1">
        <location>
            <begin position="22"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF13439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="160" mass="17334" checksum="87A596D57431A4CE" modified="2013-05-01" version="1">MPSFTTTALTLALGLAGLTSATGTLESRQAMNVKPNWKIDNKLIGCGANTCNYSFDINAEEYRATPGFNVKCESVVPLKYGQYIQCILNGATSSIVPGRAVTMVWAAVSMDPSETQESYVYAYLTFQNEMGQTENWSGAVTDSYKDFSSNPIDPIIASKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M3D6F8</accession>
    <name>M3D6F8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fructose-bisphosphate aldolase</fullName>
            <shortName evidence="3">FBP aldolase</shortName>
            <ecNumber evidence="3">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_148733</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2 3">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class II fructose-bisphosphate aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="3"/>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761565.1">
        <property type="nucleotide sequence ID" value="XM_016905115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D6F8"/>
    <dbReference type="STRING" id="692275.M3D6F8"/>
    <dbReference type="GeneID" id="27902252"/>
    <dbReference type="eggNOG" id="KOG4153">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040088_4_0_1"/>
    <dbReference type="OMA" id="MDHAQSE"/>
    <dbReference type="OrthoDB" id="2558351at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00947">
        <property type="entry name" value="TBP_aldolase_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050246">
        <property type="entry name" value="Class_II_FBP_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30304">
        <property type="entry name" value="D-TAGATOSE-1,6-BISPHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30304:SF0">
        <property type="entry name" value="D-TAGATOSE-1,6-BISPHOSPHATE ALDOLASE SUBUNIT GATY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF13444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="294" mass="32305" checksum="7F82FEF82233CBCF" modified="2013-05-01" version="1">MPLDKLENNRAVQMLNKAAAGKYGVLGVVSYNLETIVAVIRAAEKKRSPVQILLFPWALKYSPLFIDLAANAARKATVPVTVHMDHAQDPEVIKVAAKMRAADGTPSFDSIMVDMSHYEKEENLAKTKELVALCHAEGISTEAEPGRIEGGEDGVKDTAELEGMMTTEEEVDDFIATGIDFLAPAFGNVHGDYHGVENIHLDYDRLETIHKKVGGRVQIVLHGTNEFPPDIMAKCIERGVTRINVNKLVLDKYNKYTTDNWGKAPLTQLMEKGTDLIQELTEGWMDAIGSSGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M3D6G5</accession>
    <name>M3D6G5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ADP-ribosylation factor GTPase-activating protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_148738</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761575.1">
        <property type="nucleotide sequence ID" value="XM_016905120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D6G5"/>
    <dbReference type="STRING" id="692275.M3D6G5"/>
    <dbReference type="GeneID" id="27902257"/>
    <dbReference type="eggNOG" id="KOG0704">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044516_2_0_1"/>
    <dbReference type="OMA" id="MSKLWEV"/>
    <dbReference type="OrthoDB" id="983479at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030100">
        <property type="term" value="P:regulation of endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd08830">
        <property type="entry name" value="ArfGap_ArfGap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000014">
        <property type="entry name" value="ADP-ribosylation factor GTPase-activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46395">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46395:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="12"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="154"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="304"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="386"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF13454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="397" mass="42229" checksum="91323D822AAA060B" modified="2013-05-01" version="1">MSKLWEVDPETKSKLLAISKTNENNRCVDCGAPSPQWASPKFGIFFCLACSGIHRSLGVHISFVRSVTMDSFKTGEVKRMELGGNKPWKDFFDAHSSNTMIGQEFDSCTISERYDSEAGEEWKERLTAKVEGTEYVPGAPKPKVAPKKAAVESVSNTPAGSGRNTPLGGVGGAKAVPQRTSTPSQKAQNEAYFARMGESNASRPEGIAPSQGGKYAGFGSSPMPTDDYDGGRAPGVDDFQKDPIAALTKGFGWLSSTVTKQAATINSTYVQPGMKNFQQSDIAAQIRQTGLTLGTTVQQGTKGLGDQFNKFVDPDHRPQQGGAKPEKADFWESFGQAPAGPPKEKKDFWDDFSAAGESAAAQKPKPSGLGTSAMKGSSGGAGSSASKKDDDGWGKDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2022-12-14" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>M3D6Z8</accession>
    <name>M3D6Z8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_149045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762036.1">
        <property type="nucleotide sequence ID" value="XM_016905304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D6Z8"/>
    <dbReference type="GeneID" id="27902441"/>
    <dbReference type="HOGENOM" id="CLU_2623566_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF13915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="78" mass="9168" checksum="AC65E06566645EE9" modified="2013-05-01" version="1">MTHPIDRKQATYLSGHSWQYKGEPSVLRLAIWRRKSGYQRDETRFSTMHFYNSNPSKIHTPSCTEMGVQHLWCDQTGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M3D733</accession>
    <name>M3D733_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mannan endo-1,6-alpha-mannosidase</fullName>
            <ecNumber evidence="4 10">3.2.1.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SEPMUDRAFT_148904</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Random hydrolysis of (1-&gt;6)-alpha-D-mannosidic linkages in unbranched (1-&gt;6)-mannans.</text>
            <dbReference type="EC" id="3.2.1.101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 76 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.101" evidence="4 10"/>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761810.1">
        <property type="nucleotide sequence ID" value="XM_016905220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D733"/>
    <dbReference type="STRING" id="692275.M3D733"/>
    <dbReference type="GeneID" id="27902357"/>
    <dbReference type="eggNOG" id="ENOG502QSWP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025694_1_2_1"/>
    <dbReference type="OMA" id="GMFQPPY"/>
    <dbReference type="OrthoDB" id="4187847at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008496">
        <property type="term" value="F:mannan endo-1,6-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000006">
        <property type="entry name" value="Mannan endo-1,6-alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014480">
        <property type="entry name" value="Mannan-1_6-alpha_mannosidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145:SF36">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016302">
        <property type="entry name" value="Man_a_manosd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 10 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032286" description="Mannan endo-1,6-alpha-mannosidase" evidence="13">
        <location>
            <begin position="20"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="394"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR016302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMF13689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="449" mass="48531" checksum="DC3CAAA4FFCABED7" modified="2013-05-01" version="1">MRTPVTLTTCLLLPILARAIELNLDDPQSIRDAAKTAAEKMVGWYSGKAFTIPGLLPGPYYWWEAGAMFGSLIDYWYYTGDESYNAIVTEALLFQVGPDENFMPTNQSKSLGNDDQAFWGIAAMSAAEFNFPNPPSDQPQWLALAQAVFNSQAPRWNTDSCGGGLKWQIFTFNNGYNYKNAISNGCFLNLAARLGMYTGNSTFTEWADRTWDWSSSIGMISPTYSIYDGSDDALNCRELNHIQWSYNAGVYLNAAATMWNITADGPDAGKWRERTQGMLDGIQRTFFNGTIMIEAACEMSWNCNIDQQTFKAYLSRWMAASVKVAPWTHDIVMPLLASSAMAAARSCTGGSDSVTCGTTWTGDGWDGGFGVGQQMNALEVIQSNLIDQVSGPVGNGTGATSVGDPNAGTRLSDAPEAPDGITGADRAGAGIVTALVLLGMIGGSVWVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M3D7L8</accession>
    <name>M3D7L8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_9081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761995.1">
        <property type="nucleotide sequence ID" value="XM_016910538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D7L8"/>
    <dbReference type="STRING" id="692275.M3D7L8"/>
    <dbReference type="GeneID" id="27907675"/>
    <dbReference type="eggNOG" id="ENOG502S2AQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150771_0_0_1"/>
    <dbReference type="OMA" id="YYRYGGM"/>
    <dbReference type="OrthoDB" id="537467at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF13874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="86" mass="9969" checksum="80F378FFD06B1BCF" modified="2013-05-01" version="1" fragment="single">KPCTLCHTPRPVLVRCQIDDARTWHMVCPGNCWKSVSGGMEDARGREEEFPWYRYGGMWKNKHADGPISAKKPGKVKRRQKEERKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M3D7U6</accession>
    <name>M3D7U6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptide hydrolase</fullName>
            <ecNumber evidence="9">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_148020</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M28 family. M28A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="9"/>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762371.1">
        <property type="nucleotide sequence ID" value="XM_016904655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D7U6"/>
    <dbReference type="STRING" id="692275.M3D7U6"/>
    <dbReference type="MEROPS" id="M28.001"/>
    <dbReference type="GeneID" id="27901792"/>
    <dbReference type="eggNOG" id="KOG2195">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024336_0_1_1"/>
    <dbReference type="OMA" id="PNYEYEV"/>
    <dbReference type="OrthoDB" id="10013407at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03876">
        <property type="entry name" value="M28_SGAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000093">
        <property type="entry name" value="Peptide hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041756">
        <property type="entry name" value="M28_SGAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF17">
        <property type="entry name" value="AMINOPEPTIDASE Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0732">Signal</keyword>
    <keyword evidence="8 9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005140291" description="Peptide hydrolase" evidence="9">
        <location>
            <begin position="19"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="10">
        <location>
            <begin position="139"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="11">
        <location>
            <begin position="251"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF14250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="499" mass="53588" checksum="D189F2571866380E" modified="2013-05-01" version="1">MASVKAVVAAALLTSAAAWDQQPLLATNGKKLVDSEELQSAITAEKLHARAEDLFKLAELSWHEYNRPTRVIGSAGHEATLDYIWATIAQLGDYYNLTEQQFPAYSGSVAESRLVLGDEVIANASAMSLTPPTKDKEPVHGDLVLVANNGCSASDYPAAAKNNIAFIKRGTCSFGDKSLQAGLAGAAAAVIYNSENGTLHGTMGTPNPNHIATFGISLEEATPTLDKLNSGKTVDAIAYIDAVVSTIHTLNIVAQTTAGDPENCVMLGAHSDSVPEGPGINDDGSGTLSLLEVATALTNFTVNNCVRFAWWAAEEEGLIGSDFYAASLPKEENQKVRLFMDYDMMGSPNFAYQIYNATNLDSPVGSEELRDLYVDWYEKHDLNYTFIPFDGRSDYDGFIRAGIPAGGIATGAEGIKSKEEAKVFGGKAGDWYDPCYHQLCDNVGNVNMTAWEVNTKLIAHSVATYAISFKGFPERTAVDALAESVYAKNTKYHGSKLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M3D8I4</accession>
    <name>M3D8I4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_148000</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762325.1">
        <property type="nucleotide sequence ID" value="XM_016904639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D8I4"/>
    <dbReference type="STRING" id="692275.M3D8I4"/>
    <dbReference type="GeneID" id="27901776"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_13_2_1"/>
    <dbReference type="OMA" id="TCAGIQV"/>
    <dbReference type="OrthoDB" id="5215911at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF149">
        <property type="entry name" value="TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="475"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="540"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="295"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="299"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF14204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="580" mass="64674" checksum="FE81121D535B6A4A" modified="2013-05-01" version="1">MEMNTNARELHELEQELHIDIVPGTEVMTDVGSHHFVKGGGASSQVLVPQPSEHPHDPLNWSQWWKMLCITSTTVVTFTQGFGPLALAPMFGDYIKEFDSNLHDVVKFTGVCILVLGFSNFIWVPISTSCGRRPVFILSQIVCLVASIWRARATSYGSFMGACILNGIGAGPAETIQPAVIADIFFLHDRGFWNTLYWVAYMGSLMVGPIVSGSMALHLGWRSFWWLNVGLLGLSLAMVIFMFPETKWHRLHPDEIGTSSDLKTVDTKNSTSADTIERPMTSRSRMVLADEWHEDTEKSTSGGNITRVQSNHHPHHSTTSANNNRVPWLGKGAPGRSQWGIYTPTANPWKSIFIDLWTPWKLFAFPIVEFASFVVSWSCSSFLTVNLTQSQAFAAPPYNFSSQTIGFFNFAILGGSMLGLFTAGPLSDWVSARATKKNRGIREPEMRLPAMIPYVFIMILGNCIVAFGYDNHWPWQLIVILGYACAGIQVAALPAMVTTYAVDSYKPVAGSLMVSITVNKNLWGYGFSEFITPWATKHGFVPPIMTNMSLVTLWCALGVVFYFWGKQFRRWSRNSGVHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M3D8W5</accession>
    <name>M3D8W5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_115850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762706.1">
        <property type="nucleotide sequence ID" value="XM_016901202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D8W5"/>
    <dbReference type="GeneID" id="27898339"/>
    <dbReference type="eggNOG" id="ENOG502RP3H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1074295_0_0_1"/>
    <dbReference type="OMA" id="AGTRTIM"/>
    <dbReference type="OrthoDB" id="3650913at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032849" evidence="2">
        <location>
            <begin position="23"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF14585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="259" mass="26990" checksum="6024BF229D3A7A33" modified="2013-05-01" version="1">MAPLSCFSTLYVCTFLVASVSTRHIHRPQVHQHQYRQAVPVTITAVETSSLTTAVTAAAAASFAAGNDAIADIEKIQAGLSDLPADLLSLVQSVEARLEYMESVLQELVGSTSTSVSSALPVSPTLLPQPSTLIRSTTVTTPTTASSSLVPSLPALSSRNSSSTSRISYNTTTRTSRITSTRIQTITVPRATSTLPASWISRGLPSGTFTSSGNWTLPFSTSGKPAVASSSSSSSSSSSAAGTRTIMLLPPAPTAWEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M3DBK1</accession>
    <name>M3DBK1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Transcription elongation factor SPT4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_114524</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the SPT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763546.1">
        <property type="nucleotide sequence ID" value="XM_016901095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DBK1"/>
    <dbReference type="STRING" id="692275.M3DBK1"/>
    <dbReference type="GeneID" id="27898232"/>
    <dbReference type="eggNOG" id="KOG3490">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138052_2_0_1"/>
    <dbReference type="OMA" id="FDGMIAV"/>
    <dbReference type="OrthoDB" id="248751at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032044">
        <property type="term" value="C:DSIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031934">
        <property type="term" value="C:mating-type region heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033553">
        <property type="term" value="C:rDNA heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000182">
        <property type="term" value="F:rDNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008298">
        <property type="term" value="P:intracellular mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of transcription elongation by RNA polymerase I"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase I"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000232">
        <property type="term" value="P:regulation of rRNA processing"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090262">
        <property type="term" value="P:regulation of transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07973">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR022800">
        <property type="entry name" value="Spt4/RpoE2_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038510">
        <property type="entry name" value="Spt4_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12882">
        <property type="entry name" value="SUPPRESSOR OF TY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12882:SF1">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06093">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025023">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01389">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="RNA polymerase subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0137">Centromere</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Spt4/RpoE2 zinc finger" evidence="9">
        <location>
            <begin position="8"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR025023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF15425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="115" mass="12523" checksum="E83BA6B85F03C090" modified="2013-05-01" version="1">MSQVPRGLRACLVCSFVQAANKWSKTGCPNCEDFLELRNSSDAIGDCTSEVFEGLVTVNDTSTGWVSRWLRIQGYVPGVYATKVNGLLPEDYVAAAENAGIRYIPRDGSANDDDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M3DDA5</accession>
    <name>M3DDA5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_147596</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763930.1">
        <property type="nucleotide sequence ID" value="XM_016904404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DDA5"/>
    <dbReference type="GeneID" id="27901541"/>
    <dbReference type="eggNOG" id="ENOG502SAFQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019096_0_0_1"/>
    <dbReference type="OMA" id="RDNIAEM"/>
    <dbReference type="OrthoDB" id="21589at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039751">
        <property type="entry name" value="HERPUD1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12943:SF27">
        <property type="entry name" value="HOMOCYSTEINE-INDUCED ENDOPLASMIC RETICULUM PROTEIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12943">
        <property type="entry name" value="HOMOCYSTEINE-RESPONSIVE ENDOPLASMIC RETICULUM-RESIDENT UNIQUITIN-LIKE DOMAIN HERPUD PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="6">
        <location>
            <begin position="11"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="104"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="235"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="577"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="661"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="109"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="252"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="581"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="661"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="695"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="720"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF15809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="734" mass="78724" checksum="09F794659F195000" modified="2013-05-01" version="1">MAPPADAPTTITLRIKVPPGHIEGAADEFTLGADVPVSASIGEIRERIQRTVASHPAPERQRILYAGRALVDNEQTLGDALNIRRDPTQTEYVVHLLVKGDGTAATTPSRAGSHSAAARSSGAASTGPPHTNGNGIGSTQQPALGQQRTAQDSSNIAQLLQQQQARLIAQQQQFVHDAHHNRFAAGQGQGQQGQGGLPAAMLVPPAQQYGHHGLGAHLAPHLPPFIPQAHFAQPGLQAAHTDATAERPSSPAPSQADNQQRSASQPPRRPHGQGVILEGRGPNGERFHFQQHIQLGPQIPALGLPHMPHFGQHLPPPPPRRNGPSAVEQARDNLAEMRRMLADLRGLDGATDEQRSRIERLQQRTEEVQSFVDPFNIGGSTAPAATALNNLRASGTAQGMPVPRASSQLPSIFGTSDIPHFIQQPSPTSRTPADVTCYLLSSPAGPQAILYSPQHGTYTGGVAPQPTRTTQPAPMTANERPLADQAQAVAAQPVVAQAAAVQQDNLGALGPLINHMWHLLRVLIFAYFIIGANLGWRRPLAMLAIAIGFWLLRQGPLGEGGVLRRWWDGIVNQGQRPVPVAPGNNGQQQGQVQAGNMRPGQMPTPAQVAQRLLDEDRQQRNNRLSWLREQIRPAERALALLVASLWPGVGEAYVRALEAEERRRNEEEVAARRREEEERQQREAEEKKKAEEAATSTETRSSSGVAIAEGGPSTTVTADGSDKNDASEESRAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M3DEZ0</accession>
    <name>M3DEZ0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_147756</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF16089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764210.1">
        <property type="nucleotide sequence ID" value="XM_016904506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DEZ0"/>
    <dbReference type="STRING" id="692275.M3DEZ0"/>
    <dbReference type="GeneID" id="27901643"/>
    <dbReference type="eggNOG" id="ENOG502RHBR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_994057_0_0_1"/>
    <dbReference type="OMA" id="WRIETRI"/>
    <dbReference type="OrthoDB" id="3641574at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000812">
        <property type="term" value="P:regulation of barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189:SF50">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="192"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF16089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="300" mass="33700" checksum="6E1E7DF972E3E909" modified="2013-05-01" version="1">MNSSIYLYNCKTQPPTARMIPQLSDAEFDKIVKYLGGEPTKGEQAVMEAVRKGDQQRVRETSLGLTQRASLHAKLEAVILQKPEILRILLEENRSLSETIAAEAFTRKDKKCIQTILDFGWDINTCLCSVPPLYYAINDIEFMKWLIDRGADIDNRPYLDQPVLSYAIAAGDIRVVHFLLAKGADVMHGNLLHYAVERTDQREGAELIEILAQKGADVNARRHFNAAAWRFKAMSFLPTPLYLACYHENVPAVHALLKRGADPARKILCWGRDGPSALGRARSLHNPELSALLLQFCSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDB1</accession>
    <name>N1QDB1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_151373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757412.1">
        <property type="nucleotide sequence ID" value="XM_016906771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QDB1"/>
    <dbReference type="GeneID" id="27903908"/>
    <dbReference type="eggNOG" id="ENOG502RKT9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_794829_0_0_1"/>
    <dbReference type="OMA" id="KKWQYTR"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="284" mass="31810" checksum="8166AE6A2646947F" modified="2013-06-26" version="1">MLSPAQAPNRLSVLHEQHHKSTAELARTHQMLSKLYKKLSKAERVLAERQERQLTRDQRKKWQYTRVLTKRTISEMELGQFYLHDDLQQLNELISYHSSSWTTPWTGLYAPPPSAYSSLTPLSPIFTPYAEYRPAPRNQIQYWDLSGLPERSSSAHGSPSADSGYHEPAAQGLGIITEGQSQDNNEQHTDDEMKTAFAFNFESQEATENNSRDPSSQEQDDVVPDLQELVSPIADTSSSRVHKRCVSANAAQLNLGSLAPSSPKRGASVGPALDRISVILERRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDG5</accession>
    <name>N1QDG5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SEPMUDRAFT_158619</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757556.1">
        <property type="nucleotide sequence ID" value="XM_016907798.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.N1QDG5"/>
    <dbReference type="GeneID" id="27904935"/>
    <dbReference type="eggNOG" id="KOG0922">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3400">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001832_2_3_1"/>
    <dbReference type="OMA" id="LAPNFYK"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05684">
        <property type="entry name" value="S1_DHX8_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000061">
        <property type="entry name" value="ATP-dependent RNA helicase DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000191">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000101">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000191">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005570">
        <property type="entry name" value="RPABC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049621">
        <property type="entry name" value="S1_DHX8_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF85">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03870">
        <property type="entry name" value="RNA_pol_Rpb8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00658">
        <property type="entry name" value="RPOL8c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="217"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="527"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="708"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="122"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="181"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="441"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1351"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="150"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="441"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMF09435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1429" mass="160151" checksum="7AFF75E07D0925CE" modified="2013-06-26" version="1">MDDLEQLEILSLVSKITSEINNHMGVSDKTISEYVMAEHGKCADQAAFREKVAEFDFPESLADSIDRLIRTMHPRHKSTMEVSKQNGSKSEKKETQIFKGLAIADTEPVVDDFDDTFAALENLAGPPKTTTGGGRKRSVSPARYEDTKPTKRHRRSRSPRSRDRKRNDEYLFEDEFGRTRAHRPDRDERDSKRRSRRDSRERSGWKEPELDDEPVLFKVYDGKVTGVKDFGVFVNLFGVKGKVDGLVHVSAMSDQKVNHPSDLVERNQEVKVKVMKVQDKRISLSMAEVDQETGEDLVPGRKVQTGATGANSMGLGGATDFESLKPAVPVIESGAAARRQRKRMTSPERWEIRQLIASGVFKASDYPDIDEDYNAAINGEQIEEEEDVDIEVREDEPPFLAGQTKQSLELSPIRVIKAPDGSMNRAAMQGDVLAKERRDMRQQEAQDKAKAEAAKTDLNQEWNDPMVAPGERRFASDLRQTKTSNGEVPEWKKLATGRGAEMGKRTNMSIKDQRESLPAYKMRKQFLEAVRQYQLMIVVGDTGSGKTTQLTQYLAEDGLANHGMIGCTQPRRVAAMSVAARVADEVGCRLGEEVGYTIRFEDKTNEKTKIKYMTDGIMQREILLDPELSKYSVIMLDEAHERTIATDVLFGLLKKTLKKRPDMKLIVTSATLDAEKFSTYFNECPILTIPGRTFPVEIMYSREPESDYLDSALTTVMQIHLTEKPGDILLFLTGKEEIDTSCEILFERMKALGPSVPELLILPIYGALPTEIASKIFEPPPPGGRKVVIATNIAETSITIDGIYFVIDPGFVKQTAYDAKLGMDRLQVTPISQAQAKQRAGRAGRTGPGKCFRLYTESAFQSEMLPTTIPEIQRQNLSNTILMLKAMGINDLLGFDFMDPPPTNTMLTALEELYALGALDDEGLLTRLGRRMADFPMDPALGKALITSVDLGCSEEMLSIVALISAVQTVFHRPKEKQQQADAKKARFHDPAGDHLTLLNVYNGWKASGKSDPWCFENFIQPRNIKRAEDVRKQLIQILDRHRLKIISCGRDTMRVRQALCAGFFRNSARKDPTEGYKTLVEGTPVYMHPASALFGKHAEHVIYHSLVETTREYMHNVTAIEPKWLVEAAPTFFRVAGKDRGGLSKRQRAERIQPLHNKFAGENDWRLSSQRKQGRGGGDPCKGGTCRMRKSNLFPRMIILCANDYNNNNHDIRAMADAQLYEETFQVTTLIDQTYDRVHRVLGTSHDSTTSITLDINSELYPIGNGESFNMLIASTLNLDGTKDEAQGWRPKNDAPSLADMWDYVCYGKVYKVEDPEDGDRIKVYISFGGLLMCLDGPYKKLSPLKIENEESTSSEVAGAMQGSHRQRPVLNTDGRGWSARRSRSKSAGVRNAWALLSLARPTKCEMRHGSVASTGHTMLDDGRTHLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDK7</accession>
    <name>N1QDK7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_72329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757656.1">
        <property type="nucleotide sequence ID" value="XM_016909985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QDK7"/>
    <dbReference type="GeneID" id="27907122"/>
    <dbReference type="eggNOG" id="ENOG502RV54">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_603512_0_0_1"/>
    <dbReference type="OMA" id="WFHPYGR"/>
    <dbReference type="OrthoDB" id="422736at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22997">
        <property type="entry name" value="GT_LH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36587">
        <property type="entry name" value="EXPRESSION SITE-ASSOCIATED GENE 3 (ESAG3)-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36587:SF2">
        <property type="entry name" value="EXPRESSION SITE-ASSOCIATED GENE 3 (ESAG3)-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="349"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="429"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="544" mass="61805" checksum="3714BE17D1A00C7D" modified="2013-06-26" version="1">MNLPACSRWLREALNQLLLRPLWPQQDEDTIGLLSEKVLPPASFCRGFVPKQINRLRGAVIALAGISLLFLGASGSARRYRYQNSFHWAENLARISWTGQSQDHYLHVVIAAEPSYVELCKTMLSGFVLSYPSPWVAVPKSTRDEHGRESSAVVRKLESILEFLEHENGSRDNDTAIILGNSYTWFQVRPEVLLKRYMDIQRRHELMLLDDFGPKTVAAHRIKPKVLFASHWTFPSSNNTAENCLPIQSTDGSPRYLSHDLVIGLIKDLTPLYQYALDQAIKLNDSIASFDEHTIFSDMFRAQQLHRQSLAKLGEEVHDAAELDTLLDEHDFDFGITLDMDSDLRYHLSSSSTSSNNNNPHPSNWTRYDLRTDRHSPAFPKDIALSAPPYWTITGTLPSKTWEQVSLLSVFSNHPQIPALIQHDEFSSNDNNDNNDNNPYQNATAAATPPIAHSSQKWSQYPNLWFHPYGRALLDSEALTGIVPIARLVDPRTGIRQRFWVQGIGKASVKTAEVERYEWDDVCGDWDVAEEVFRDGKGPWMDPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDL7</accession>
    <name>N1QDL7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Smg4_UPF3-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_151536</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RENT3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757681.1">
        <property type="nucleotide sequence ID" value="XM_016906877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QDL7"/>
    <dbReference type="STRING" id="692275.N1QDL7"/>
    <dbReference type="GeneID" id="27904014"/>
    <dbReference type="eggNOG" id="KOG1295">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018549_0_0_1"/>
    <dbReference type="OMA" id="QYKPGKV"/>
    <dbReference type="OrthoDB" id="18087at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12455">
        <property type="entry name" value="RRM_like_Smg4_UPF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039722">
        <property type="entry name" value="Upf3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005120">
        <property type="entry name" value="UPF3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13112:SF0">
        <property type="entry name" value="FI21285P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13112">
        <property type="entry name" value="UPF3 REGULATOR OF NONSENSE TRANSCRIPTS-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03467">
        <property type="entry name" value="Smg4_UPF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF3" evidence="6">
        <location>
            <begin position="35"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="203"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="523"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="203"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="311"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="388"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="430"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="528"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="556"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF09560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="582" mass="60831" checksum="5B7D893E101ACEC6" modified="2013-06-26" version="1">MPPKVLAKTEGAKGLLPVNAATRAAATAPKPPAPRLKLEVRRLPPGLTLEEFEGILGDEWKLGNGKVDWLEYRQGKVKLSLGKVPEQSRAYVHLVDEAAISAFEARFLAVTFQDKAGTYRNPDMKHLPPTLGFAPNQRTTINTKLRSDNRQGTIDQDPEFIAFLEAETQPIARSAAIDSVSVDSETPEKVVIKSTPLIEALREKKASKAKAVESNKSDKKDGKGHARNESKNDAAPEKPAKETKNQQQQQKLENAAKEAVKAVNKQVASKQLKDQQRPASPQQPQQKAQSQAKGKKASQAVARDAGGGKGAESAKADAGGATRRDNNTPAKPAANTATSKAVTPADAAGGKQTAPRAPRQRGNADGIKKMLQKDLAGIRPKNAPAAGASKPTVPTTSTTATSGSASSPAATPTATKEQPQKQSPKPPTAPKALAQAKQQQQPPATTVSTTKAYLKHANPSQGMTEILIQQALSQFGEVANVTIDPRKGTAIAIFKDPEGLKKAFVAKKVPVANGNVEILEWKERSAGQSGGNRTGGFRGGRGGGGARGGRSGNAGSGAAHASAASAQSAQPATQPPKAANGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDN1</accession>
    <name>N1QDN1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_111053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757717.1">
        <property type="nucleotide sequence ID" value="XM_016900894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QDN1"/>
    <dbReference type="GeneID" id="27898031"/>
    <dbReference type="HOGENOM" id="CLU_816760_0_0_1"/>
    <dbReference type="OrthoDB" id="10638432at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="340" mass="37466" checksum="9AAEDD2699221864" modified="2013-06-26" version="1">MDIDNHHDRDDEGRMIMTRDSSSPSLGLGVPPDPNSNEYADTVQFGEADVFPDQAGIASARGASSVGLEYLGAPPDPASEEYKRTVQFGEGDVFPDQPHLNKRGQGSNTKSSDHDDEAPSSTRTRKKTRPENSTVARRSGRIPEPSTKGKQILAEANRQGRGSDFSGAATSVNTFGETGEEEGEVEANEMATRRGITTSSTRKTAVASSSNDMPSRSIGPAKNVAWQSSEELKIALRMVYSKEYESQLNTPQRKADVWNEAVKDIETIKARNAFVPEQTMATQYSERNSSRKIPSVTHWKTVIEKMAPDDPKWVDMKQKFDAAIVELDRTNRWSTTILLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDP0</accession>
    <name>N1QDP0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_151572</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757736.1">
        <property type="nucleotide sequence ID" value="XM_016906900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QDP0"/>
    <dbReference type="STRING" id="692275.N1QDP0"/>
    <dbReference type="GeneID" id="27904037"/>
    <dbReference type="eggNOG" id="ENOG502RXZ0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063930_0_0_1"/>
    <dbReference type="OMA" id="VMNVMIR"/>
    <dbReference type="OrthoDB" id="410198at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF09615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="296" mass="32878" checksum="FA0F588090490379" modified="2013-06-26" version="1">MINMASQCNQSFAATAIISHDLAEKRATDHLATDVGLATTTTTPKNMSLAADQVQAAVAAKKPIGKPSGDGVRILTLAEYKEAALSLAEAFKDDHTSQYFTHTPDRAHWTEQQRWELHVKVMEYITYAHLLKGLVVSAGPNYDCVALWMPPGKDIDGYSTLFRSGLWRLHYQLSRVGRTRFFHEFLPLLTTTKLQTLGPRRDADSWYLVYIGTRAASRGKGYARQVIEYVTRQADAERRACYLESSHVVNLVIYGKLGFEKKGEIVLGRGGEEEIGLDVMVREPVGEDGDSGVDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1QEX9</accession>
    <name>N1QEX9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ATP-NAD kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_86797</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759808.1">
        <property type="nucleotide sequence ID" value="XM_016910424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QEX9"/>
    <dbReference type="STRING" id="692275.N1QEX9"/>
    <dbReference type="GeneID" id="27907561"/>
    <dbReference type="eggNOG" id="KOG2178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008831_10_2_1"/>
    <dbReference type="OMA" id="IPKYQES"/>
    <dbReference type="OrthoDB" id="24581at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042736">
        <property type="term" value="F:NADH kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.30:FF:000009">
        <property type="entry name" value="Poly(P)/ATP NAD kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF26">
        <property type="entry name" value="NADH KINASE POS5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF11687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="439" mass="48099" checksum="CABC4F2929D61CAF" modified="2013-06-26" version="1">MRAILRSWRSIRAPTRSLPSARCFATSAARREVRSIAELPDRVHSRFQETKSHDLLALEWPSPPRNVLIVRKDDSAECHRAVIEYAHHIHDVYPGTSVILESYLAHRIHEEFAFPIYASNGEGHPAYEQKVDLTSTFGGDGTILHAASLFATAKSVPPVLSFSMGTLGFLGEWKFAEYKRAFREMYMSGAPSTMPAKSTDEPEQKQRSSAWTAARGKSMGVSRSSRILLRNRLCIGIFDSDGNRLPHEAPFAHADSKCEDIFALNEVLLHRGALPHLAHITILIGSAPHQKILTTAIADGFLVSTPTGSTAYSLSSGGSIVHPLVSSILLTPICPRSLSFRPLVLPANTPITLRIEEQNRGKEIEVSVDGVRRREGLKSGMEVRVVGEEVRSAGAPGSRDWLRGVPSIVRSGGVGDGQDHWVGGLNSLLKFNYPFGEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFE3</accession>
    <name>N1QFE3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_150559</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758578.1">
        <property type="nucleotide sequence ID" value="XM_016906257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QFE3"/>
    <dbReference type="STRING" id="692275.N1QFE3"/>
    <dbReference type="GeneID" id="27903394"/>
    <dbReference type="eggNOG" id="KOG0257">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034385_1_0_1"/>
    <dbReference type="OMA" id="KNWRYPG"/>
    <dbReference type="OrthoDB" id="2108at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050596">
        <property type="entry name" value="AspAT/PAT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46383">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46383:SF1">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="7">
        <location>
            <begin position="91"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF10457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="479" mass="53577" checksum="4EFC1E44E8EB2E94" modified="2013-06-26" version="1">MSGIAFRGGNQGEHPPMQGHKPTTTKARRFSTAQGPSNDEINSAIHLQFRQAHEGHKPHAGLDPSRASTGVIWCTERAYEHGFADDPSSWANLGQGAPEVDDEIEGCFKRPQTIDISMTGREYGPTAGIKPLREAVAKLYNEHHRKGKESQYTWENVCIVPGGRAGLIRIAAILGNAYLGFFIPDYTAYNEMLSLFKNFTPLPIPLNKNDNYQIHAEKIEDEISRGTSVILTSNPRNPTGKMIAKGELAEIQDLCRDRATLIMDEFYSGYNYTSDCDGSVVSAAENVEDVDDDGVLIIDGLTKRFRLPGWRVAWILGPKEFCKALGSCGSYLDGGTNVPFQEAAVPMLEPDNVRAEMKALQLHFRMKRDYVVDRLQKMGFKLSYTPDSTFYLWLNLEHLPHSINDGLNFFQACLREKVIVVPGIFFDLNPARRRDLFDSPCHHYVRISYGPVLSTLVKGMDGIERVLQKHGAYSDDESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFF8</accession>
    <name>N1QFF8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Adenylate kinase isoenzyme 6 homolog</fullName>
            <shortName evidence="10">AK6</shortName>
            <ecNumber evidence="10">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Dual activity adenylate kinase/ATPase</fullName>
            <shortName evidence="10">AK/ATPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_126386</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. Involved in the late cytoplasmic maturation steps of the 40S ribosomal particles, specifically 18S rRNA maturation. While NMP activity is not required for ribosome maturation, ATPase activity is. Associates transiently with small ribosomal subunit protein uS11. ATP hydrolysis breaks the interaction with uS11. May temporarily remove uS11 from the ribosome to enable a conformational change of the ribosomal RNA that is needed for the final maturation step of the small ribosomal subunit. Its NMP activity may have a role in nuclear energy homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with small ribosomal subunit protein uS11. Not a structural component of 43S pre-ribosomes, but transiently interacts with them by binding to uS11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the adenylate kinase family. AK6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="10"/>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760159.1">
        <property type="nucleotide sequence ID" value="XM_016902063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QFF8"/>
    <dbReference type="STRING" id="692275.N1QFF8"/>
    <dbReference type="GeneID" id="27899200"/>
    <dbReference type="eggNOG" id="KOG3347">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079096_3_1_1"/>
    <dbReference type="OMA" id="QCEIFGT"/>
    <dbReference type="OrthoDB" id="10251185at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000372">
        <property type="entry name" value="Adenylate kinase isoenzyme 6 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00039">
        <property type="entry name" value="Adenylate_kinase_AK6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020618">
        <property type="entry name" value="Adenyl_kinase_AK6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595:SF0">
        <property type="entry name" value="ADENYLATE KINASE ISOENZYME 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595">
        <property type="entry name" value="POS9-ACTIVATING FACTOR FAP7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13238">
        <property type="entry name" value="AAA_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 10" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="LID" evidence="10">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF12038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="199" mass="22543" checksum="06EDF3C72DE13E00" modified="2013-06-26" version="1">MLRTEPNIIITGTPGVGKTSHAEELARRIPGLHHMSINEIVKKHNIGEKSDDPSDPSLQIVDEDRLLDVIENDLEEGGQIIDWHACDLFPPSLIDLVVVVRCENGLLYDRLKGRGYQGKKLEENLDCEIMEVLLQEARDAYDGEIVVELHSEKTEDIDSNVDRIESWVNQWKKDHGKAEGDVKAQSEQKDEENPMFLHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGF2</accession>
    <name>N1QGF2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_55433</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764397.1">
        <property type="nucleotide sequence ID" value="XM_016909358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGF2"/>
    <dbReference type="STRING" id="692275.N1QGF2"/>
    <dbReference type="GeneID" id="27906495"/>
    <dbReference type="eggNOG" id="KOG0273">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018409_1_0_1"/>
    <dbReference type="OMA" id="QIWSVES"/>
    <dbReference type="OrthoDB" id="1367865at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045183">
        <property type="entry name" value="Ebi-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22846:SF2">
        <property type="entry name" value="F-BOX-LIKE_WD REPEAT-CONTAINING PROTEIN EBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22846">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="91"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="91"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="170"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF16276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="668" mass="73231" checksum="586E1111EE45BA91" modified="2013-06-26" version="1">MSAAAALHSNHVNYLVWRYLQEQGFEHAAIAFTRDWRRTGDIASDPDALSFAPEVRRNDLVSVVQYGVHYDQARAKAGLNNGERKFAWSKIEGRGSLERQRDPAENGASTRPATGRRKEKPPAVRTVDGARGQPPRASRKSEAGDAHLNGDARDAMDVEPGSVDGEPEQEATSPTVASESDQAGPVERYDSMDVLIQTDIKAGLNSSTISWLLDKPGATIHRAIWNPKPDVDDSKTLLVVGNDLCRFYQIPSSANNAQHLENIDEPNLSTSCCVTAATWRHDGTAACCAIDKLRQLPSGTQLSQQELIERHSNGTSTSLQLGPAMLEPPGIVLGIHYSPDSKYVLALRTNMKRSTIQVWPSFRPDVDTLPLSEPIAWRLFDIQVCDVTWISNDTFAVCGENGLAALYQIDESQSRGLGVLPVGNVLMRGLMSRNSNIVEGTSHWDYVRYDPRYCIAAFVSRADKRLLFTSKLRSGEISSSTDVEFALPEDKLLEPVAFSTEQLVNQGEQIGNTDVESLFAAGFSDGTIGLFSARHSLETGLECKTLGDLTLLESPTTALAWSPDNEHLAASSSNLVQIWSRDSFNKRNGIVQSPRTIFTWRPQDLAGHENGIENEEGNRLVTCQPSLTWSADGRSLAFATEEQISIIALDAPVQDEKLNTTMNGHHAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGP5</accession>
    <name>N1QGP5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_117628</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759770.1">
        <property type="nucleotide sequence ID" value="XM_016901352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGP5"/>
    <dbReference type="GeneID" id="27898489"/>
    <dbReference type="HOGENOM" id="CLU_809338_0_0_1"/>
    <dbReference type="OrthoDB" id="3642733at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="103"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="283"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="293"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF11649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="343" mass="38198" checksum="118F5D786D800CE7" modified="2013-06-26" version="1">MDDNVNSFYSNTEPLSSQQPRKPNYSRPTNIRNNNPQPGMKRALDLRNNAEYSYFDDNTSEDEDEVQRNTLAKNSTAEFASSEGLNIGTSTGPHALGNRRMGNTQPIINPSELLSTATDRSNRRTNTQALINPRYEREPLPTTPIRSTPLAPTSALSYPGQPSHGRKRRRIIQPPYPSSTNIPNISNDDATPTKQQSPPPPPPGMFGTQARSIRGGRSTPDMPNQLDLSAEEVIRQLQDVPGMLAGTLTELAQMFDDLAQKHNILEERITLLEEENRALRSPSLISRSLPARQQRTSARTGTSYQFIQEDPGRTSDDHRSARKPSLAGFRPLKPLKPFPPPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGQ6</accession>
    <name>N1QGQ6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_149585</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759780.1">
        <property type="nucleotide sequence ID" value="XM_016905645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGQ6"/>
    <dbReference type="STRING" id="692275.N1QGQ6"/>
    <dbReference type="GeneID" id="27902782"/>
    <dbReference type="eggNOG" id="KOG1502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_9_2_1"/>
    <dbReference type="OMA" id="QEQAVWD"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="11"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF11659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="370" mass="39970" checksum="2D3B164A71E6227A" modified="2013-06-26" version="1">MADSGDTKDTVLVTGGSGHLGGYCVLQLLQKGYTVRTTVRTTSRIDEAKGKYRHGGATEEQIASVEFVVLDLVSDSDEDWTKACTGAKYVLHTAGMIATGLEKHEDELLIPLKTGTLRVLRAAKAAHVQKVVFTSSVAAIAHGHGMKRGKSEPFTEEDWTDLSNQKEKLHVYPRAKTLQEQAAWEYIHSEAGQGLEMTTINPVALYGPSLSKNFASSLKLVPILLGGMPGVPQYGTGMVDARDVADLHIRAMESSAANGQRYLAISGRSHELEAAKDSVCDFVNMILSGDILRQGLPEEKTGKIPTRTLPNFVMRAAGYFDPVVGVCLPDLGKELAGSFAKARRELGWEPRTIDEALLSSAKSLVEFGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>N1QHE6</accession>
    <name>N1QHE6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cu-oxidase_3-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_156781</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759985.1">
        <property type="nucleotide sequence ID" value="XM_016907696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QHE6"/>
    <dbReference type="STRING" id="692275.N1QHE6"/>
    <dbReference type="GeneID" id="27904833"/>
    <dbReference type="eggNOG" id="KOG1263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006504_3_1_1"/>
    <dbReference type="OMA" id="DHSKMAM"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13854">
        <property type="entry name" value="CuRO_1_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13880">
        <property type="entry name" value="CuRO_2_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13901">
        <property type="entry name" value="CuRO_3_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000021">
        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000038">
        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF145">
        <property type="entry name" value="LCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109576" evidence="7">
        <location>
            <begin position="20"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="143"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="268"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="490"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF11864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="673" mass="73844" checksum="79E20606F3298B77" modified="2013-06-26" version="1">MMSTYRLFAAVTLLASSLAAPAPVPQAEFNVAKTNTTDNTPEDSTLLALDDEGEIQNLGGPAGSEYNFLSWVPLGQDLEPKLSQEQTNGNSKLGTFDAPKLPRFLEGTAISQGFPWGGRTAENTDYYHDTPNTGVTVHYDFTVSTMTIAPDGVEKQSIVINGQYPGPTIEANWGDWIEVVVHNALDEGTSLHWHGLLQTETPWFDGVPGVQQCPIAPGGSFTYRFRADLYGTSWWHSHYSAQLAGGAFGPLVIYGPHDNQDYDIDLGPVMINDWFHKDYFTLVEKVMAPAAENQPPPISNNNLINGKMNYPCANSTTGTKCTPNAGVSKFSFESGKSYRLRLINAGAEGMQKFSIDGHKLTVFANDFVPIVPYETDVVTLGVGQRSDVVVKATGKPTDAVWMRSDLGPAFAAGGCSLTDGVSPVALAAIYYEDANTPAVPTTTSDISIDKIKTCKNDDLRLTVPYYPIPLPPPTTEQNIDVTFQSNGTHTLFYMNNSTFRANYNDPVLLDAKNGDRDFPASYNVFDFGSSTSIRLVVYNYAPTGSHPMHLHGHNMYILAEGTGIWNGDVTHANNPQRRDVHLLQNAISTTQPSYMVIQFDADNPGVWPFHCHIAWHVSGGLYINVLERPDDIQKEMSIPEIMAQTCTDWDAYSSRDVVEQIDSGLRIRDGLSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2023-02-22" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>N1QII5</accession>
    <name>N1QII5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_118939</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758505.1">
        <property type="nucleotide sequence ID" value="XM_016901464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QII5"/>
    <dbReference type="GeneID" id="27898601"/>
    <dbReference type="HOGENOM" id="CLU_1305541_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF10384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="211" mass="24163" checksum="C86A67081BB0774D" modified="2013-06-26" version="1">MGFTLDISRLTRPSEHEVIDLPVFWSTSYPARLLTRHPDLAQPKLLYPYQRLHTARHYRLHSPYNDNRSHLQTAYSHRMSRLCKKVRQYLPALDSVHMAVCLMHSMRFKFMKTANGVTGLTDRWPDTLLLGKGVAARRWAKQPNPNAWLYGQCLDRDGPGAEAIMHATEVLDIEVFIFSGVGLPGQNAKQQRISERQMLTTLLAAEDHVAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1QIP4</accession>
    <name>N1QIP4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_149987</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760410.1">
        <property type="nucleotide sequence ID" value="XM_016905894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QIP4"/>
    <dbReference type="STRING" id="692275.N1QIP4"/>
    <dbReference type="GeneID" id="27903031"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000134_20_0_1"/>
    <dbReference type="OMA" id="EAENVGW"/>
    <dbReference type="OrthoDB" id="10057496at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24188">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24188:SF29">
        <property type="entry name" value="GH09064P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="97"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="158"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF12289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="197" mass="21124" checksum="56099DD985B923BC" modified="2013-06-26" version="1">MHSTALPALTFDEVDDLLYFTRANEAQELQQTITELAQKYSCSQKDVLEAAVDPESGNTVLHFCSANGLTQLLPSLLSALGATEGSPIEFVNRGNKEGNTPLHWAAYNGHLEIVKALIASGADMWQKNTAGHLAMFEAERADKNDVVQYLLEAGGKEVERAGEEGMPSEEDVVEVQDGEANSSAQASAGDVDMDNAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1QIZ5</accession>
    <name>N1QIZ5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein Zds1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_146282</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765302.1">
        <property type="nucleotide sequence ID" value="XM_016903550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QIZ5"/>
    <dbReference type="STRING" id="692275.N1QIZ5"/>
    <dbReference type="GeneID" id="27900687"/>
    <dbReference type="eggNOG" id="ENOG502RC08">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004908_0_0_1"/>
    <dbReference type="OMA" id="VDYNWTR"/>
    <dbReference type="OrthoDB" id="5589766at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040206">
        <property type="entry name" value="Zds1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013941">
        <property type="entry name" value="ZDS1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28089">
        <property type="entry name" value="PROTEIN ZDS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28089:SF1">
        <property type="entry name" value="PROTEIN ZDS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08632">
        <property type="entry name" value="Zds_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01327">
        <property type="entry name" value="Zds_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein Zds1 C-terminal" evidence="2">
        <location>
            <begin position="780"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="722"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="839"/>
            <end position="942"/>
        </location>
    </feature>
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        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
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        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
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        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
    </feature>
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        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
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        <location>
            <begin position="401"/>
            <end position="412"/>
        </location>
    </feature>
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        <location>
            <begin position="487"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="518"/>
        </location>
    </feature>
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        <location>
            <begin position="527"/>
            <end position="544"/>
        </location>
    </feature>
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        <location>
            <begin position="577"/>
            <end position="586"/>
        </location>
    </feature>
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        <location>
            <begin position="613"/>
            <end position="623"/>
        </location>
    </feature>
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        <location>
            <begin position="637"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="673"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="722"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="848"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="902"/>
            <end position="940"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF17181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="956" mass="106417" checksum="A1AB354D1F063E12" modified="2013-06-26" version="1">MAEVQQRQRQAELERLYRARKNNAASSSNSSNTALAALSSPSRHSPQLSISDDTHHVTETIHSWYEETPSTAAAASMNERHAVRPLSYINSPSERESFEARRQRRHGALINSASNASVISDDSLATTPLARAQSNQSLTSSNLSEHHGNDDSHGQNSPTSLQRIGSRGAESSPTSPPLLSRQSSTDTAVQQFPLNDIDYESSPAAVAQELSNLQAIRRMSMNVDTADPDLPSFGGVSSISSVAPPSDGDEDDPSKLFWVPARLHPELAPKEFRTFIEDRVDRIRRRSGDENSLAPDNLSRSGSAASSLRRKKSMLSHSIDTRGNYQDGAERLERKRSKGMQVEGQTTVANLQDLEELVNDPTHLMRRMSLETQRRSLDSGAEVPPNEDMPILPPAMGTLKRSTRTTYRRGSLKKGERVPFSKRAAHRHPDQEGDGHGSQSSTTVHTEDREPTPGLSRVRTEPIPPPKDSQIGQSRPRHDRTNQYGQSQSSESLSNEEASRSSISSRNEPERYEYEEHTVPQPPASQPPKQFQSRIASQGRTTAQLPGYDNKNPLPQIVETLADGSKVPASNVVQSIPERKSSHEVPRQFQRGGAHMRPASGRSNASSTKLDDLSSNPSPLPGSGSMGTATLTMIPTFDEKKAEKKDGSRKSSWKWILGSDDKTKDDGSGGAESTKSSKSNKLSKASADKARLDVLQNSIDGTVPARGRESIVLSREDIKLDDERKKDGKKGESSKSHREKDSGLLSAIFGNKKKTSDGDVKEKKKKGDRHHSPEPPSRVLKPDIDYNWTRFSILEERAIYRMAHIKLANPRRALYSQVLLSNFMYSYLAKVQMMHPQMQIPAQRTAQQREQQQQQQKQPQSQSQSPPSSSSSSSSQQQQQQQYPQQQQQQQHPPEYNQYQRWQEEQARQDAKHTHSEARTDFDVVHDGQREQGNGRRTSADEWEQLFARVQSGEHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJD9</accession>
    <name>N1QJD9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tripeptidyl-peptidase II</fullName>
            <ecNumber evidence="4">3.4.14.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SEPMUDRAFT_129352</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal tripeptide from a polypeptide.</text>
            <dbReference type="EC" id="3.4.14.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="15">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.14.10" evidence="4"/>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764523.1">
        <property type="nucleotide sequence ID" value="XM_016902282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJD9"/>
    <dbReference type="STRING" id="692275.N1QJD9"/>
    <dbReference type="MEROPS" id="S53.010"/>
    <dbReference type="GeneID" id="27899419"/>
    <dbReference type="eggNOG" id="ENOG502RXDG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013783_3_3_1"/>
    <dbReference type="OMA" id="PEIAWEG"/>
    <dbReference type="OrthoDB" id="409122at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000015">
        <property type="entry name" value="Tripeptidyl peptidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF34">
        <property type="entry name" value="TRIPEPTIDYL-PEPTIDASE SED4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 15" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0843">Virulence</keyword>
    <keyword evidence="13" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase S53" evidence="16">
        <location>
            <begin position="197"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="502"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="544"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="545"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="580"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="582"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMF16402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="625" mass="67728" checksum="64BFCAA98D8D1C64" modified="2013-06-26" version="1">MVHECLSGLPHGWSVSDSTVYNNTLMHLSVSLKYQNLNKLESQLALVSTPGSPKYGQYQDLDSQNAMFAPSTDAANKVKSWLSKSGATNIVSDGVTVRFDSSVAKANQMMSAAFKLYTDGQTTKLRTMSYSVPEDLAQYIDIISPTTYFGEMKAQAVLPREEEIPTLTTRDKPSQPQLNPACTTTYVSKRTGRHYDLLTPQCLSELYNTGGYKVDPKSGSSIAFANFVNQTPSYSDLDLFEKAFNIPEQNFTVLALLNGAVNDQNPLTEMDGEANLDVQNIVGLVDGLPIYTYITGGIAPAIPDLQSPNASLDTNEPFAEYYQYLLSQPNSKLPYIFSQSYGDHENTVPPKYAARVCNMIGMLGLRGRTVLASSGDQGTGVICRANLPPGNVIEGAPQFEPRFPTTCPYVTGVGGTQSFNNEIAWNATGGGFSKYFKTAWYQKSAINTYLSKHISPATKTYYSSNNFVDFHGRAIPDIAAHSLYPDYATFINGSIAPNGGTSAATPVVASIIALLNDARLRAGLPAMGFLNPWLYGAAADTLNDITEGSAVGCNGIDIQNGNPLPGAAIIPFASWNATEGWDPTTGIGTPDFWKMKSRALETCAWGNVPSEIWRFPPVGGWSWKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJM6</accession>
    <name>N1QJM6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_150748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016906373.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="27903510"/>
    <dbReference type="eggNOG" id="ENOG502R8YZ">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_740031_0_0_1"/>
    <dbReference type="OMA" id="GQHEVCR"/>
    <dbReference type="OrthoDB" id="3632630at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF10744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="374" mass="40433" checksum="D2E89508CCDCF704" modified="2013-06-26" version="1">MLSPHSSPSSSPSASSMSSPEIRVTDDHGNGAVVQLPAALAEQIMVEQRTRALTFEVPVAEKQLEMHARPASLRSASSETAMEPLVTLKPAPTSNPLDSPVSLRGKGKEVKRVASAHGSLRMSLKSMTSAGLLSSKKKHATDDGKSSTGTSGAASPTQVDTPEVKVILAKKTCPDLDAVSRALESLGCQDRPTSDPLVLNLKSLEQKIKGAREDCSKMLTRAMQARDRQQYEVCRALCIQIVQNQHSKVETRVYAYNILSTQASPGQAMNFLKEAAKLAKQCEGPEKDKLTSIVAMLQEHALSKESNRDATKNNEAIVDLGTFQRRPTMPKMKMPSDANVLQLPKDHMPRGAMTPKSEKIFNWALPSKAKTAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJX3</accession>
    <name>N1QJX3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Zinc-binding oxidoreductase CipB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_150814</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758970.1">
        <property type="nucleotide sequence ID" value="XM_016906413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJX3"/>
    <dbReference type="STRING" id="692275.N1QJX3"/>
    <dbReference type="GeneID" id="27903550"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_16_5_1"/>
    <dbReference type="OMA" id="LDCHMQD"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="4">
        <location>
            <begin position="27"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF10849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="355" mass="37508" checksum="57590EE656F0826B" modified="2013-06-26" version="1">MAEQIKQAVSSVLPGQSGNQAAWLDKESRHPLRVGPADMPSAGDGEIVVKNHAIAINPVDWKIQDYGLFVQKWPFVLGCDVAGEVYEVGKNVTKFQKGDRVFGHSTTLATQNTSHGGFQLYTAIQAHFAGIVPSKLSYNEAAVLPLAINTAGQGLYDTREKGFLGLPFPSLNSQPIGKTILVWGGSSSVGALTIQLATASGAKVITAASKHNHAFVKKLGAVAALDYKDPTIVDDVVKAIQAAGGEFAGIYDAIATEDSFKYTFAIAEKMGVPNVAGTLPPPEKGAPETVKYGNVFAINEINKPLWENFVSQALEAGKLLAVPEPLVVGKGLESVQKGMDTNKAGVSAKKVIIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1QK37</accession>
    <name>N1QK37_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LIM-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_146551</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765686.1">
        <property type="nucleotide sequence ID" value="XM_016903723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QK37"/>
    <dbReference type="STRING" id="692275.N1QK37"/>
    <dbReference type="GeneID" id="27900860"/>
    <dbReference type="eggNOG" id="ENOG502S0PM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_373848_0_0_1"/>
    <dbReference type="OMA" id="AHLFQQP"/>
    <dbReference type="OrthoDB" id="774557at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029005">
        <property type="entry name" value="LIM-bd/SEUSS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10378">
        <property type="entry name" value="LIM DOMAIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01803">
        <property type="entry name" value="LIM_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="666"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="266"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="689"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="700"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="718"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF17565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="742" mass="80716" checksum="93E27D0242D3364A" modified="2013-06-26" version="1">MMAAYQPTPGGVHPGLQHGHPGMGPNPGQHMGQPMQMHPGVSGAPHQGAMMGMQPGANGMGPGGMGGQHPGAGMAMAAHMGGQSMAGGMPNAQALSQMTPQQQLAHHHQQQQQFAAMAGQNPQFAMQQHQMRLRQQALMQQAQASGMMNVNQPGMQMNPQLAQLQQQQAAQQAAQAAGQPVQLTPNLQQQQMQMMQQQAIQRQQAAQQQQQQHQQTQLAQQMAMQHANSQQSNPGQAAPPNPQNQAANAAAQQMRPQSRVANPNEQTPNSQQQHSQQSPAQQAQAQAQQTPQQGQAANPQQQAPQQQQMTQAQRHASMALFQRQQAMQAAQANRLAQQQQQANAQGGMFILKLMNFNDHLSNFSLDNDNPAANGKDITHWHNFVEKHFAADGRLIHSFPNTDHNGNPNRKSYEVLRPNVARYFYTYFDSGASSLRLHTEHAREAPHPTTGGQQVTCQKAIFSIAYPNGARLEMTGSLQVLFSAGSDTIECLSFQTTSTEETLSRGQIERVLADFSPTMSHKASPKLAKNKLPKAQQKLQEAENRITIDHFPKTPKGTMGFTSKVQHFLEIGETMNIMSDLMHAAQEKKLRPEQALEALVGEWEQGGNPQIHFPPNGAAQGSRTPSMANMQMGPNGQFSSPSMSHMSLPINGSPHIGHHGNLAPGMNMANSHTPSPHQLHMAAPPMMPQHSAQGTSSSIASENTSPNLNNNNKRRRSTVKMEGDDHDSARVKPSPRLGKKAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKK4</accession>
    <name>N1QKK4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_113765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765907.1">
        <property type="nucleotide sequence ID" value="XM_016901051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QKK4"/>
    <dbReference type="GeneID" id="27898188"/>
    <dbReference type="eggNOG" id="ENOG502SUS8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053382_5_0_1"/>
    <dbReference type="OMA" id="DIGIHKE"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38846">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38846:SF1">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF17786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="111" mass="12574" checksum="19B5C20CAE22E5EF" modified="2013-06-26" version="1">MAKTKAQKIRATIDYFEQTYGSTPTLATWQAFCRDVGVNEGNSITQCKKILKSVNVNIVDFVSARKSGQAVTHFASRGALARYIQAYPKKRFPLKRAKEDSFLKMLLIHLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKN7</accession>
    <name>N1QKN7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_66997</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759877.1">
        <property type="nucleotide sequence ID" value="XM_016909771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QKN7"/>
    <dbReference type="STRING" id="692275.N1QKN7"/>
    <dbReference type="GeneID" id="27906908"/>
    <dbReference type="eggNOG" id="ENOG502SI37">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013869_1_0_1"/>
    <dbReference type="OMA" id="ECPGYVQ"/>
    <dbReference type="OrthoDB" id="5418899at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF9">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF11756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="734" mass="80843" checksum="6EEA5C9C89F21886" modified="2013-06-26" version="1">MAQEPSERACDRCRERRVKCDKTQPTCLRCEKLGKPCPGYDKKRKFVDEGASLRKKYQSSAADDSVVAASPRPLQTTVRASSSAAVQPQPSITSPAVGLAVPVAVPAFTSPALPLPPPSSSPSSTLLPSFEALNNSLAVPRTEIGNISPSLVWPGSALDPPVQIPLTNDDLMLDEVWKNENFDPEYFDLQPDAYYSAAGNTCGFLPNIPEIVDEVDQSDILLASNSASATPLSTAIFSGSFSDSNLGAPESQLNTSALITSERDHEMAYLIRHFTESLGPWMDLFDRDKHFTHLVPLKALRDALLRNAIAAVAAKQLGRVKGRKPFTGRQYQKPSAMEVLDDTPAQVDWFYKAANYYDKAIAFSRQYLQAVSGELSDVHSPNTQHAAAAVSLANSDDLVVAVSIFSLYESLDNLETGGWLQHLAGLKSLLGAVSPSQQVQNQVSPSLTVGRLASFWNFARADYQAAYTNKQRTLLDTEDVALWNSCGLEIQEDGSIYKSSEVVKNESPHHSRVLADELVAHTLLWLVLRVMNYLASDETNSTARQSQWDLLVRQLDHWYGNLPDTFQPCAQIRHPTASGRTHHQQQRSQLFEVFFSIDICAAAIQLYHFARILLLLHRPLTASTTTTTATSDNNNNNITIPRNRLQAYRQVSTESIRHAHEIIGIALGRPQPAIRVEMLLPLSIAGACLEEHDEREVVLDLLHAIELDTGCATAARCEELRREWGWGDEPLGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKZ3</accession>
    <name>N1QKZ3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SEPMUDRAFT_145583</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764414.1">
        <property type="nucleotide sequence ID" value="XM_016903142.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.N1QKZ3"/>
    <dbReference type="GeneID" id="27900279"/>
    <dbReference type="eggNOG" id="KOG0519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_50_4_1"/>
    <dbReference type="OMA" id="WVMKPIN"/>
    <dbReference type="OrthoDB" id="2015534at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009584">
        <property type="term" value="P:detection of visible light"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000048">
        <property type="entry name" value="Sensor histidine kinase/response regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.270:FF:000002">
        <property type="entry name" value="Sensor histidine kinase/response regulator, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013654">
        <property type="entry name" value="PAS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016132">
        <property type="entry name" value="Phyto_chromo_attachment"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013515">
        <property type="entry name" value="Phytochrome_cen-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043150">
        <property type="entry name" value="Phytochrome_PHY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43065:SF10">
        <property type="entry name" value="PEROXIDE STRESS-ACTIVATED HISTIDINE KINASE MAK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43065">
        <property type="entry name" value="SENSOR HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08446">
        <property type="entry name" value="PAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00360">
        <property type="entry name" value="PHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50046">
        <property type="entry name" value="PHYTOCHROME_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0157">Chromophore</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 11" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="1" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Phytochrome chromophore attachment site" evidence="13">
        <location>
            <begin position="450"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="14">
        <location>
            <begin position="827"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="15">
        <location>
            <begin position="1298"/>
            <end position="1429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="132"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="177"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="378"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1071"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1112"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1482"/>
            <end position="1532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="177"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1112"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1135"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1160"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1281"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1486"/>
            <end position="1509"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="11">
        <location>
            <position position="1349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMF16293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1532" mass="169976" checksum="C0F7876BB5917758" modified="2013-06-26" version="1">MASSEQQQQEEEGLRQASRTESEDMPTPTTSAPDATTSDHDPPTTNRPSNIPIEDLRHRSASAAKDQPPSPGQNAEAPPSPAATDRVFPIRSVVSVDPTPTPFTKSEKPDGYFQTSASRMSSAEAFHAARGRYTGERSGSEGAGTSSRQGSTSTTSTAQHSSPAQKIHYSQTFNEMMTDTDSTGSVQEDSLKHTRADSNGRLSSARAPSLMSIKSSIDDTGPLVTARFKHVVTDGGHAIITGRDGETLQRCEDEPIHIPGAVQGFGLLIALEEEQEGKLVVRTVSENCRRLIGFTPQQLFSLDSFTDILSDEQADNLLDHVDFIREEDADVVTNGPEVFTISIRNPSRKSQKFWCAMHINERNPNLIICEFELEDDPVNPLVPPNDMTPEPPEDTLDSRPTEEEYLESTQNTSKPLRVLRSARKRKGEAAAMEVFNIMSQVQEQLAAAPNLDTFLRILVGVVKELTGFHRVMVYQFDQHWNGRVVTELVDPRATKDLYKGLNFPASDIPKQARDLYKVNKVRMLYDRDQETARLVCRTMEDLESPLDLTYSYLRAMSPIHIKYLGNMAVRSSMSISINAFEELWGLIACHSYGSKGMRVSFPIRKMCRLVGDSASRNIERLSYASRLQARKLINTVPTQSNPSGYIIASSEDLLKLFDADFGLLSIRDETKILGHLENGSQEPLAMLEYLRMRCVTNVMTSQDIKEDFPDLRYPPGFKEIAGLLLVPLSVGGQDFIVFFRKGQLKEVKWAGNPYEKFVKEGTEGYLEPRKSFRTWSEMVVGKCREWTEEEIETAAVLCLVYGKFIEVWRQKEAALQNSQLTRLLLANSAHEVRTPLNAIINYLEIALEGTLDQETRENLAKSHSASKSLIYVINDLLDLTKTEEGGELVKDEVFDLSGTLYEATDMFKGDARRKNISYQVTDHPGLPRQVIGDQRKIRQAISNVTANAIQNTKEGSVKVDMYVASRTDNHVEVEISFVDTGLGMSAKKLDSLFRELEQVQSETTDLLSEPVVPKKSLPDPVKPVEGRTLGLGLAVVARIIRNMNGQLRLKSEEGKGSRFVIQFPFEISEDENKQQALPAEGSQGSVTPHAEKSLEPVTPPTEDMLTLIERSSTTPSATPAALSPPGMPRKHSAESVGSRNSLGSYRSGRSNMSKSSNRSGKSEADRLIEAISEPHRVEGWHENSVKRTNSRGSGVSVDSRLNRRHTGTRPDQNISSPRKRSGSGEIAPAPETLPDMKPVKPSRSDVKDSGMPIRAVRMPDEFSSSPTPEQPIRPPVINEKAPNTTSNQQSTVDTLHMKVLVAEDDPVNSRIIKKRLERLGHEVTLTVNGEDCASSYCDRPGFFDIVLMDMQMPIVDGLTSTKMIRSFEKSHPAQVLSTRAAMNGRVPIIAVSASLIEKQRRHYMDSGFDGWILKPIAFGRLSEIMEGIVDRQVRRENLYQPGSWERGGWFSEVQKNLFVADTTPSALPPLTEPSEGVKIAAVSDDPQVKEENDSEQTREQIRLAEKQDANEGESEATEVPTGDEATTDSAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1QLA2</accession>
    <name>N1QLA2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Synaptobrevin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_146858</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the USE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016766086.1">
        <property type="nucleotide sequence ID" value="XM_016903913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QLA2"/>
    <dbReference type="STRING" id="692275.N1QLA2"/>
    <dbReference type="GeneID" id="27901050"/>
    <dbReference type="eggNOG" id="ENOG502SCD1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027976_0_0_1"/>
    <dbReference type="OMA" id="YAWIFGL"/>
    <dbReference type="OrthoDB" id="3231855at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019150">
        <property type="entry name" value="Vesicle_transport_protein_Use1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13050">
        <property type="entry name" value="USE1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13050:SF7">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN USE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09753">
        <property type="entry name" value="Use1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="85"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="167"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF17965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="309" mass="33943" checksum="39C731C8FAC77050" modified="2013-06-26" version="1">MATPTTLSRYLTRLESSLADPHTRSSPYERNRIAANIEHARAMLLTLEKETSTVRVQSSKQATQAELQKSREWIKRLNGRLLEMNSAAHDDDDEDDDDSEKDGVNYNSYGPAISGTEAGLEVRTGTGGLGKAGGDEEEMLRDVQPQQHQQEIRARKQAPSSSSSSSNLKPTDNKSAASTTAREQLFAGRNASKTQQSNPSLSNSESLLSHNRVEQETLTSGLLALARSLKESSQQFGASLESEKDILKRAGQGLDKNAAGMEAAEKRMGALRRMSEGQGWWGRIKLYGMIFGLWVACFILVFLGPKLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1QLF8</accession>
    <name>N1QLF8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein transport protein SFT2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_122538</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Nonessential protein required for the fusion of transport vesicles derived from the endocytic pathway with the Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Golgi apparatus membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the SFT2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765243.1">
        <property type="nucleotide sequence ID" value="XM_016901778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QLF8"/>
    <dbReference type="STRING" id="692275.N1QLF8"/>
    <dbReference type="GeneID" id="27898915"/>
    <dbReference type="eggNOG" id="KOG2887">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099529_3_0_1"/>
    <dbReference type="OMA" id="PTHNEGP"/>
    <dbReference type="OrthoDB" id="660759at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011691">
        <property type="entry name" value="Vesicle_transpt_SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137:SF36">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN SFT2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF17122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="216" mass="23753" checksum="C4A1F9E21E74A628" modified="2013-06-26" version="1">MASSSFRDSMNSLGWSRRADEPVNTAPQNPILGTLSKLNPFASAGYVRLPTTEGEGPGAPLPARTRREEEEGWFALSRWDRLLLFGGLNLAAIALFVVCFTLMPILSLRPRKFAILWTMASMLFLGSWAILMGPMVYVRHLVSQERLPFTATYFGSIALTLYFAVGLRSTILTLLTSIVQIVALIWYLVSYFPMGSQGLRLAARFGGGRISAALNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1QLZ9</accession>
    <name>N1QLZ9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_145996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764989.1">
        <property type="nucleotide sequence ID" value="XM_016903394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QLZ9"/>
    <dbReference type="GeneID" id="27900531"/>
    <dbReference type="eggNOG" id="ENOG502T0B6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125044_1_0_1"/>
    <dbReference type="OMA" id="SHRVWAQ"/>
    <dbReference type="OrthoDB" id="2933464at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF16868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="161" mass="17876" checksum="6B7122A6DB7D09DE" modified="2013-06-26" version="1">MAVCSLWSGTHSHSLGSSSRASYEAAQTKHKTSSTMSRPIRESIKRLRGWVMGSESRMKKIVRGEGAPGTRAAPTQSGNNDKKIGLRLDHGDIVVKDGKKFRRYKLQINKGAENPTLKALADKDSHRVWSHADIPIDDTDKTEPGKLLETFFEDLETNIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1QM62</accession>
    <name>N1QM62_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA-splicing endonuclease subunit Sen15 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_137700</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEN15 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765089.1">
        <property type="nucleotide sequence ID" value="XM_016902851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QM62"/>
    <dbReference type="STRING" id="692275.N1QM62"/>
    <dbReference type="GeneID" id="27899988"/>
    <dbReference type="eggNOG" id="ENOG502SC4F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083361_1_0_1"/>
    <dbReference type="OMA" id="HPDDQIA"/>
    <dbReference type="OrthoDB" id="10002170at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042777">
        <property type="entry name" value="Sen15_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018593">
        <property type="entry name" value="tRNA-endonuc_su_Sen15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28518">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28518:SF1">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09631">
        <property type="entry name" value="Sen15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA-splicing endonuclease subunit Sen15" evidence="4">
        <location>
            <begin position="51"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="103"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF16968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="211" mass="23988" checksum="A76C29FED28A6889" modified="2013-06-26" version="1">MGLPTVPPQPPSPTSALQSLLSKPTLSQQTSSSSPTESHHHHHHYYNLALQIAHNLHYQHLWTDIYLHHNTPSLREKNCRPILSGLPPRRIYVHPDEQIALLQEKKKKEQKDEEGKNGGGGDGGMMPEIAREREWVLPSQVREKWSLRRLGEVFDSIERVPSSSSRVGSQGVVVNQWRENSPKRLLLATLDDDSTVVYYIVHDGIVKPRQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1QM74</accession>
    <name>N1QM74_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EthD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_34117</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tpcK family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765513.1">
        <property type="nucleotide sequence ID" value="XM_016908560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QM74"/>
    <dbReference type="STRING" id="692275.N1QM74"/>
    <dbReference type="GeneID" id="27905697"/>
    <dbReference type="eggNOG" id="ENOG502RFY1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115019_0_0_1"/>
    <dbReference type="OMA" id="GIRRWTQ"/>
    <dbReference type="OrthoDB" id="3454835at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009799">
        <property type="entry name" value="EthD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07110">
        <property type="entry name" value="EthD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EthD" evidence="3">
        <location>
            <begin position="41"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF17392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="165" mass="19269" checksum="469090CBCA818419" modified="2013-06-26" version="1">MSQQTTVPLTSSSTLEPPIPDPANTQIGSRYLCLTVLGYKKPGLTDEEYRMHMNRISAPLTKDLMAKYGIKRWTQVHNTQKTRGLMEFIMDRQMRNIADYDCFSQVTFNSIEDYKNIKKDPWYQEHLVGDHEKFADTQRSLMTIGWIEEFIHDGTPCEKLEFPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1QMV6</accession>
    <name>N1QMV6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nuclear GTPase SLIP-GC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_32857</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765005.1">
        <property type="nucleotide sequence ID" value="XM_016908514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QMV6"/>
    <dbReference type="STRING" id="692275.N1QMV6"/>
    <dbReference type="GeneID" id="27905651"/>
    <dbReference type="eggNOG" id="ENOG502QU12">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005249_4_1_1"/>
    <dbReference type="OMA" id="VAQGYMK"/>
    <dbReference type="OrthoDB" id="3598281at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056024">
        <property type="entry name" value="DUF7605"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36681">
        <property type="entry name" value="NUCLEAR GTPASE, GERMINAL CENTER-ASSOCIATED, TANDEM DUPLICATE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36681:SF3">
        <property type="entry name" value="NUCLEAR GTPASE, GERMINAL CENTER-ASSOCIATED, TANDEM DUPLICATE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24564">
        <property type="entry name" value="DUF7605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin N-terminal" evidence="3">
        <location>
            <begin position="92"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7605" evidence="4">
        <location>
            <begin position="744"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="435"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1005"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="379"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1014"/>
            <end position="1047"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF16884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1058" mass="118097" checksum="63EAA210C6C76D02" modified="2013-06-26" version="1">MPEQEYLPHPQEPLFSAQDDYDLDCAERGVPLAQLANEETPERLEAGVSIGLKVLSELESAMKKLGANEDATAYLNLIDRTRKEAVQTRTVVGVVGNTGAGKSSVINALLDEERLVPTNCMRACTAVVTELSYNHSSNEAAKYRAEIEFIKPEEWRKELNVLFKEVFDDEGRISKEVSNPDSEAGVAYAKMRSVYNKKTREMLSNSSVQTLMNDKKVRSVLGTTRKINARDPSTFYKSLQRIIDSKEKGQEKLDKNGNINHNVKREFEHWPLIKVVKIYLKAPALSTGAVIVDLPGVHDSNAARAAVAEGYMKQCTGLWIVAPINRAVDDKAAKTLLGDTFKRQLKFDGTYSAVSFICSKTDDISRTEAADSLQLGDQMTELDARLNLIDEERRKVKRKKKEAEDHFEDQEAVYDEVDGSLEVWEELMSQLENGKTVYAPQQDRSKKRKLSSSSPPPRKRPHRAIDSDDDTGEAVETASDPERQALTEEDIAKKLGELKQLKKEARNAKNDAKARIGDVGHELKRLDEEEDELEAKKSAICIAGRNEYSRGAIRLDFAKGIKELDEEEAQDSDDFNPEEDLRDYDEVARSLPVFCVSSRAYQKLSGRMKNDNAVPGFTQLSETEIPQLQAHAKKLTVKGRQANCRRFLNSLKQLMLSLALWSSDDGTGNNLTLQQRDVEKTFLSRKLKELEVHLDKVVETTLSDVAEEMSEQLLAKLTGSAVDAAVRAAGPKAESWGMPKPDGGLHWSTYRATVRRNGNYAGSSGPRDFNAELAEPIYKHLASAWEKTFQRRLPSILQSFKRSATSVVKQFHTAVETRTRERGTGAARLNLLAQQLDQYSATFGDLCSKAVTSLNEGQRDINREFVPAIAVAMEPAYNEASEEKGTGSFKRMKGRVNDHVTTSKQQMFHSAAEQVRRSLLKLCGTIKESMLCKADEVYLAMQRDYTSVLSGVNVGDIQLSREERATRREVDQLITGADEHFAEVMQGELDELKDKFDAQMPIVEKDQDVADDHMDVDDFEDVDSESDADEDDDGSDGAESAQLEEQEMGGATPTADDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1QMW4</accession>
    <name>N1QMW4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pal1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_146702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765858.1">
        <property type="nucleotide sequence ID" value="XM_016903808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QMW4"/>
    <dbReference type="GeneID" id="27900945"/>
    <dbReference type="eggNOG" id="ENOG502SNMS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054780_1_0_1"/>
    <dbReference type="OMA" id="FWHSKSN"/>
    <dbReference type="OrthoDB" id="5397330at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF17737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="269" mass="29855" checksum="895305A77D3242AD" modified="2013-06-26" version="1">MAIIKNPFRKQDENVRPAPTPLANDKPTSSSSSTKQFDVDTKKPVEYKLSEINDSGVFMPPSPTEKKSFWGGTTASRSTTSSSLHKCAFNENEQFNISRESFDSYRRSFDISARSPVIQAESRPRASLDSRTFLPPPRMSNSFHRPLQVPQTQEEDKFEDVDIDDPKPQPQKKRGIFARMVDGVGDHSNRPNGSFENPPRSGAWHTLTGRKRGDSGRGAELGAMPKATEVARREQTPEPEKQVPAPQMPQQSEASVAASTQAPEIKVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNW9</accession>
    <name>N1QNW9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="7 8">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_146710</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the PPP phosphatase family. PP-Z subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="7 8"/>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765870.1">
        <property type="nucleotide sequence ID" value="XM_016903813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNW9"/>
    <dbReference type="STRING" id="692275.N1QNW9"/>
    <dbReference type="GeneID" id="27900950"/>
    <dbReference type="eggNOG" id="KOG0374">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004962_3_1_1"/>
    <dbReference type="OMA" id="AEIMAIC"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000006">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011159">
        <property type="entry name" value="PPPtase_PPZ/Ppq1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF484">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE PP-Z1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000909">
        <property type="entry name" value="PPPtase_PPZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="10">
        <location>
            <begin position="332"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="57"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="137"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF17749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="542" mass="59038" checksum="28648B8E18318A12" modified="2013-06-26" version="1">MGNQPSKEKDGKSSGSQTPTGSGPELGSYPSFSKSDTKESSRSFRTALRTKIPGKSSADSPRASTSNLSGDNSTTSLDKTDSQSVKSATSGRSGRHSRGASGSIADTSRRGSLAGDETEDQPPPSPTMSSSVLSGHHFSEIEEAQRSGEVDAVSDAPPQGNIHQTLNKEPTESILMKRPQRETNGQGAAAALAIAEGPESRSPSTSGDMAIGALKPADLDDMIKRLVDAGYAGKVTKTVCLKNAEITAICNAARELFLSQPALLELSTPCKIVGDVHGQYTDLIRMFEMCGFPPNSNFLFLGDYVDRGKQSLETILLLLCYKLRFPENFFLLRGNHECANVTRVYGFYDECKRRCNVKVWKTFVDTFNTLPIAAIVAGKIFCVHGGLSPSLSHMDDIRNIARPTDVPDYGLLNDLLWSDPADMEADWEANERGVSYCFGKKVIMEFLQKHDFDLVCRAHMVVEDGYEFFNERILVTVFSAPNYCGEFDNWGAVMSVSGELLCSFELLKPLDSSALKTHIKKGRAKRNSMLNSPPAAQFPQSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1QP09</accession>
    <name>N1QP09_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1754-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_113921</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016766070.1">
        <property type="nucleotide sequence ID" value="XM_016901063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QP09"/>
    <dbReference type="STRING" id="692275.N1QP09"/>
    <dbReference type="GeneID" id="27898200"/>
    <dbReference type="eggNOG" id="KOG3410">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098435_1_0_1"/>
    <dbReference type="OMA" id="RMEVMER"/>
    <dbReference type="OrthoDB" id="205403at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013865">
        <property type="entry name" value="FAM32A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13282">
        <property type="entry name" value="PROTEIN FAM32A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13282:SF6">
        <property type="entry name" value="PROTEIN FAM32A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08555">
        <property type="entry name" value="FAM32A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF17949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="182" mass="20133" checksum="D8E0FFCD3E913F63" modified="2013-06-26" version="1">MPSSDYTSAVGGGLKLKGSSGGGIDKKKKKKKKPQSSSDDKPSSTISDATTTTIAPTKNLHEKSALQQQSSALADGEEQEHEREGEDGEGAEEEEQNITTKEITTLKKKTTTTTTTPPAAEEEVKTYGKTEAQRRHEERRKKRLEERLQREGVKTHKERVQELNKYLSTLSEHNDMPRIGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M3AT40</accession>
    <name>M3AT40_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_158843</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756805.1">
        <property type="nucleotide sequence ID" value="XM_016907807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AT40"/>
    <dbReference type="GeneID" id="27904944"/>
    <dbReference type="HOGENOM" id="CLU_1409608_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004031508" evidence="2">
        <location>
            <begin position="25"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF08684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="193" mass="20522" checksum="CAFE1AEFD4465B23" modified="2013-05-01" version="1">MEVVRAAAVMVMVVVVVLVVVLEEEEEDEETLLPLKDGLGQELWDGGEQSRAIGQLKSASLPARTHSCVAHDSARHSLPRSPTTTDDDDDDDDDSGGSAAQPGSGPSCTATPLAQQQQQSNDTGNRATGRQGDRATGRRSVGPGCRWTEAVEESNSEPKKPLSAAHEVSSIGGTFHISHHHPRRLIPRYSGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M3ATR8</accession>
    <name>M3ATR8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TPR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_151805</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757020.1">
        <property type="nucleotide sequence ID" value="XM_016907055.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.M3ATR8"/>
    <dbReference type="GeneID" id="27904192"/>
    <dbReference type="eggNOG" id="KOG1127">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001688_2_0_1"/>
    <dbReference type="OMA" id="CQWELDP"/>
    <dbReference type="OrthoDB" id="421075at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055087">
        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039226">
        <property type="entry name" value="Ski3/TTC37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040962">
        <property type="entry name" value="TPR_22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15704">
        <property type="entry name" value="SUPERKILLER 3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15704:SF7">
        <property type="entry name" value="SUPERKILLER COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18833">
        <property type="entry name" value="TPR_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13174">
        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="3"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="37"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="437"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="633"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="667"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="709"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="962"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="996"/>
            <end position="1029"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF08899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1395" mass="153578" checksum="DCF4ADF327CA2DD0" modified="2013-05-01" version="1">MSAKAALKAAKAALDNKQYDQAIEHANSVLSADPQNYFAKLFLGRALEKQSKYDEAANTYQSAAKAKPDDSQAWQGLVSVYKAQGPKRVDEYRDAAVKIAEHFAKADDLNRAQSTVDELTAFTKQYGTPAQNKKVLEVMLPGSPIYDSLEGRIPRASHTLTRLIELTEAEEAERMKKEINERRTRIGAKIGQVTIDVKREVFASSKLEELYQQLINWSSDDELRRQHEEKLLQRAYDTLVVLPIEQKAPKLDQVLTLAEGMVIIHHPFRLAWDLVLESRDMDDLKDLDAGILREYVVLFEESGIARILQGWLSSELSPFPAPPKSEVDEPSEEIRPEDRLLLFTEGLTAAEQSPFAHRLVSDYYLHLEEHPSAAETARNGLKVAQVEGSKIGLGLQNTRDALNAVLGTSLVHHQAPRNHPEAKRLFEEILQRKPKFTPALIGLGLILEETEDYQDAIDFFLRALAEDKGNVRVGTELAWCRALSGDYPQALEELNDFLQTIRADDPRTRDLRAQTIYRIGVCVWESDQSKSARRDRNGAYSHFLAAIKTNVNYAPAYTKLGIYYGDYAKDKKRARQCFQKAFELSPAEVEAAERLAKSFADQGDWDIVEVVAQRVVDSGKARPPPGSKKKGISWPYSALGVVQMNKQEYQQAIVSFLAALRISPDDYQSYVGLGESYHNSGRYNSALRTFTYALQPHDNAKLKISGETWFARYMLANVHRELGEYDEAVSGLKGVLEDRPSEFGVLMSLLQCYVEHASRCVETGLYGQAVQCAISALSVAALVAKDTPHAFNLWKAVGDACSVFSWAQSKIENFPSDQVQDLLSLSAEQSMYELLADVDFISLAALDTDSANGTASASLPEPSVAAILAYKRAIHSAAHDLHAQAVAWYNLGWAEQRAHASSTAKAGRRHLTTAVRCFKRAIELEAGSPELWNALGVVTTTLNPKVAQHSFVRSLHLNELNAKVWANLGVLYLLQNDVELAHQSFGRAQSTDPEYAHAWVGEGIIALMTGDTKEALNHFTHAFEISDSASLISKRQYATSSFDYLLSTETASNDLTKLIQPIFALEQLRTQVPKDLPYRHLAALFLERVGNHTAAIETLTELSETAEADYEASESLSALAQYALAKSDLSRNQLATADFSAAAENAATALDLSSDADSSGLDAEARRKLRLSAHLTAGLAQYYLQDMSESVSMFKAALVESGNDPDIVCSLVQVLWAQGGETEKDVARKQLFSAAEQHPEHIGVITLLGAIAALDNDEDTANAVRDDLRALRTKDCISSKKQLAGIETLLEALAGLFSSTERSDETVLTEVQTAILLNSKDAHAWSQLAALTGEDHAAQMALQTSAQAVPPHGSMHAADLARAFAGVGSVGDAQRAAFMAPWESAGWRALSEALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M3ATW6</accession>
    <name>M3ATW6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_151820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757045.1">
        <property type="nucleotide sequence ID" value="XM_016907066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3ATW6"/>
    <dbReference type="STRING" id="692275.M3ATW6"/>
    <dbReference type="GeneID" id="27904203"/>
    <dbReference type="eggNOG" id="ENOG502RV9E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1008905_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF08924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="28481" checksum="BB4528FBCD12BF0F" modified="2013-05-01" version="1">MNRPREEDNLLGTYPASSLAEADQWEDVLYKTVSSALHTFFSSANCQSPLRPTGSSTSNSLHSFNKHTTFVFEPPLSVKMKTSTILAFIATAVLSNATPISEEKRDYAPAGYGSSMTPPPPSSPVPNYPPHAIPPPQPWSPTYPPTVVPPPGSPVYPPPPSGPVPPPGPPKFPPTGYQPGYVGPPKVQPPTDEPTDDPSSTPGSCSVEQTNACCNGESTSVGTGLLGPLLGGNCSPLAEIGGECGSANVACCPTTTTGGDGLTLISIGSICQLVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M3ATY0</accession>
    <name>M3ATY0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GA4 desaturase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_151832</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757060.1">
        <property type="nucleotide sequence ID" value="XM_016907072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3ATY0"/>
    <dbReference type="STRING" id="692275.M3ATY0"/>
    <dbReference type="GeneID" id="27904209"/>
    <dbReference type="eggNOG" id="ENOG502SMV5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042688_2_0_1"/>
    <dbReference type="OMA" id="DTHGFQW"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF3">
        <property type="entry name" value="OXIDOREDUCTASE AN1597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF08939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="294" mass="33111" checksum="14047549FE68A526" modified="2013-05-01" version="1">MPHSTASAPGTVEATINYHFKPALGESPPSPVPGTVGAVRQKLNAQAVRITDIRSTDNRFHVHRHGFQLVRFTGPEGLKYETFDDGDKIKNKFYDEVKELLKTELGATYVFVISHRLRRESYQSVLDLPADTPDTQKFSQIVPTMNVHVDQSYDGAEMLVDMLQSQGGEATDLKAKTKSCRWAIINVWKPLKTVTREPLALCDSTTVSDAELRAVKLRAPPMEFFEVAHSPEHKWYWQSNMEPDEAFFIKCFDSKTEGVARNSPHSAFILPDGQGSPRESIEIRCVVCWENESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M3AW58</accession>
    <name>M3AW58_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_150035</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF10980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759101.1">
        <property type="nucleotide sequence ID" value="XM_016905923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AW58"/>
    <dbReference type="STRING" id="692275.M3AW58"/>
    <dbReference type="GeneID" id="27903060"/>
    <dbReference type="eggNOG" id="ENOG502SNAE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049749_2_1_1"/>
    <dbReference type="OMA" id="FDVITMN"/>
    <dbReference type="OrthoDB" id="6329284at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF110">
        <property type="entry name" value="RHODANESE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="2">
        <location>
            <begin position="82"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF10980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="312" mass="35108" checksum="76B20AE829A65FD9" modified="2013-05-01" version="1">MDTRQAPNSIDVNGPVSGASTNHLTRFTGDNRKAWDAIAHDWELNQSPEVNGQAEDGNDMFTQCLLPVLDELVHWTEGETVLDLGAGSGIIARRFARKGANVTGLDFSQRMMDKGRERYEKEKDQFPGTIEYGFIDLMDVEGMVAYMQKRKDALGEAEDHRFDIITISTTLKSLPSLEPIAQALPAMLKPKGRIVVIDLHPAFSKPAGHRGMEIFEDPSTGKQQLSTYIKVPKYLNIPPCLSEAVRGQAEPLWVFHRPFWSLMEPFFKNKLVLDAMREPAFEGQPDIKQAQSYHNFQQTPMLLGFRLLHAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M3AX99</accession>
    <name>M3AX99_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Wax synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_68872</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759471.1">
        <property type="nucleotide sequence ID" value="XM_016909844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AX99"/>
    <dbReference type="STRING" id="692275.M3AX99"/>
    <dbReference type="GeneID" id="27906981"/>
    <dbReference type="eggNOG" id="ENOG502STW6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038717_0_0_1"/>
    <dbReference type="OMA" id="DNYFAFM"/>
    <dbReference type="OrthoDB" id="72269at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004031535" description="Wax synthase domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF11350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="388" mass="42736" checksum="54F0E376D1C4BF4A" modified="2013-05-01" version="1">MAFMRYLTVVPLAGLVVVAHLALQKQFEQNGLWSLDSIKVYKNRTLPNTNLPIKLPSTGSETLDNYFAFMTAFFWTSFDPRNVRAHLQGNHLLGTLSSIWIIQLLEAHGTMRTASAGMVFATYFLEVMGELLGIGLFTPIWCIVHLLLTAAPTTKANVKVTKLSASKSNMRALGYALLFGHVVPTLLMLQLDADGDGLSSKQFWTIARLFHPLFLLGTLQVFKPVFGGASTVSEPPERLLATRRKLYQFSILASGFFHVTSLGMLLAERMFTGWLREDVVSNLHIGTMFIPAPFWTGEKMTWETGVAVFLQWDYTCSSAAILLWATSQYLEASSSVGKSKGISLLETTGQALLHAVLAGPAAAAAFLLQERDTTLAAGFVESKYVKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M3AXA3</accession>
    <name>M3AXA3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AAR2-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_164868</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAR2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759476.1">
        <property type="nucleotide sequence ID" value="XM_016908135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AXA3"/>
    <dbReference type="STRING" id="692275.M3AXA3"/>
    <dbReference type="GeneID" id="27905272"/>
    <dbReference type="eggNOG" id="KOG3937">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024943_2_0_1"/>
    <dbReference type="OMA" id="GAHFFWV"/>
    <dbReference type="OrthoDB" id="201752at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13778">
        <property type="entry name" value="Aar2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13777">
        <property type="entry name" value="Aar2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.550">
        <property type="entry name" value="Aar2, C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007946">
        <property type="entry name" value="AAR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033648">
        <property type="entry name" value="AAR2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038514">
        <property type="entry name" value="AAR2_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033647">
        <property type="entry name" value="Aar2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038516">
        <property type="entry name" value="AAR2_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12689">
        <property type="entry name" value="A1 CISTRON SPLICING FACTOR AAR2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12689:SF4">
        <property type="entry name" value="PROTEIN AAR2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05282">
        <property type="entry name" value="AAR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20981">
        <property type="entry name" value="AAR2_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAR2 N-terminal" evidence="4">
        <location>
            <begin position="6"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="AAR2 C-terminal" evidence="3">
        <location>
            <begin position="190"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="416"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="428"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="464"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF11355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="483" mass="54223" checksum="0E0544F63BBCF3FC" modified="2013-05-01" version="1">MDSIDTPALLLLDLLPAALAGIDLLSFTVTPRFRGVKNLPPGFHFAFVGTSTAFSERHGLWFRVPGRASSDGQHLFITKWEASTETLKTETDETERLRWRANLGSIWKEGLTPYRQTSTDTHVEAGREEINDWPALTSAITASVLTRTTKGDANHWYLTSASSARRDIEDIPGLDEDDKNAMQADRELNFLPIDLKKTWREGATGRERTEAAQDFSWALLHLVETQCTDRDINEILGELQFCFLMILSINNFSCLEQWKRLLMLIFTSKSVVDEKSDFFIKAIAALRLQLQHCKDAEGGLIDLADEGGSLLKTLLVRFRNGLEGMTGIGVSDVADELDDLEDYLRQEHGWTLGGDHLRSGVLELEDGEQLHVESTMYDEDDETGEYAPQIVDLTPEQARLLNITPEDTRKLGLELSKSSLHDPAQEVVESDEDSDDDDDDDDDDDDDDDDGAETEAHSVVLGASDDEEEEEEMQDLENMDSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M3AXT2</accession>
    <name>M3AXT2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YIP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_150451</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759671.1">
        <property type="nucleotide sequence ID" value="XM_016906183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AXT2"/>
    <dbReference type="STRING" id="692275.M3AXT2"/>
    <dbReference type="GeneID" id="27903320"/>
    <dbReference type="eggNOG" id="KOG3103">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074741_3_0_1"/>
    <dbReference type="OMA" id="PFQANYG"/>
    <dbReference type="OrthoDB" id="440385at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045231">
        <property type="entry name" value="Yip1/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236">
        <property type="entry name" value="GOLGI MEMBRANE PROTEIN YIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236:SF2">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="8">
        <location>
            <begin position="135"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF11550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="330" mass="34530" checksum="F37ADEB4E46949BA" modified="2013-05-01" version="1">MANYAYQAPPNNAYNTANPAQNLNFYQSSYSNPQQPVSGQTTPFQAYGSAAQQSQGYGQPYAAGGGGGGASSAANYGFGAFPGQPGASGQMGTGQGGLRTGWLAAFGTEGYDGEPPLLEELGVNFSHIQMKTLTVLNPMARIDQHIMDDADLAGPFLFCALFGTFLLLSGKLWFGYVCGLAALGAFSLHFVFSMMSPPLSSDEVAAIQNHSASQYQGSSHFSSTLTLGRSSSVLGYCLLPLVFASLLGVALPLDTFIGYCLVSLAISWCTYSSSAMFCVVGRMSNMRGLVAYPLALFYAGFGIMAVFSSRGTGRIDQMTKTAAGLSGGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M3AZK6</accession>
    <name>M3AZK6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_149475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761063.1">
        <property type="nucleotide sequence ID" value="XM_016905574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AZK6"/>
    <dbReference type="STRING" id="692275.M3AZK6"/>
    <dbReference type="GeneID" id="27902711"/>
    <dbReference type="eggNOG" id="KOG1027">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062257_0_0_1"/>
    <dbReference type="OMA" id="IMVADDR"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990604">
        <property type="term" value="C:IRE1-TRAF2-ASK1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070059">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036498">
        <property type="term" value="P:IRE1-mediated unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045133">
        <property type="entry name" value="IRE1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954">
        <property type="entry name" value="IRE1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954:SF6">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="32"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF12942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="318" mass="35268" checksum="E0991D1D4EF6E624" modified="2013-05-01" version="1">MDYETADGSQFSLREIWSEDPNPTNTTTATTTHTTKPINSPKFEHTLITAFVDGNAYAGKSLQRISAMDDVDVFGYLEPVPSENIFPIMPAEFTRAPPFDMANHYLKAPQFTYEDSRPGRTSVADRLRNEARVLEFLMGQGRRRRRMENGDGNDVVGGKDEVGGDEVDAAAAAVPHPNVVRYYGCVLKDERITHLCLQRCYCNLAEYAEVGLSSEETDELLGQVQEGLKFLHGLGLAHNDIHPGNICVDSHGNAIIVDFDSCAPFGQPLTKGVACMTSTTTEKGVPVSDKKNDYEAFKELVQFLKKERKRSSACYPQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M3B110</accession>
    <name>M3B110_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">dihydroxy-acid dehydratase</fullName>
            <ecNumber evidence="14">4.2.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">SEPMUDRAFT_148729</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:24809"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:24810"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:27694"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:27695"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IlvD/Edd family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.9" evidence="14"/>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761558.1">
        <property type="nucleotide sequence ID" value="XM_016905111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B110"/>
    <dbReference type="STRING" id="692275.M3B110"/>
    <dbReference type="GeneID" id="27902248"/>
    <dbReference type="eggNOG" id="KOG2448">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014271_4_1_1"/>
    <dbReference type="OMA" id="STQGRNM"/>
    <dbReference type="OrthoDB" id="3851628at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00057"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004160">
        <property type="term" value="F:dihydroxy-acid dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.80:FF:000001">
        <property type="entry name" value="Dihydroxy-acid dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="entry name" value="IlvD/EDD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00012">
        <property type="entry name" value="IlvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050165">
        <property type="entry name" value="DHAD_IlvD/Edd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004404">
        <property type="entry name" value="DihydroxyA_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056740">
        <property type="entry name" value="ILV_EDD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="ILV_EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00110">
        <property type="entry name" value="ilvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002068">
        <property type="entry name" value="PRK00911.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000:SF5">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24877">
        <property type="entry name" value="ILV_EDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="IlvD/EDD N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00887">
        <property type="entry name" value="ILVD_EDD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase N-terminal" evidence="17">
        <location>
            <begin position="74"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase C-terminal" evidence="18">
        <location>
            <begin position="406"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF24877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EMF13437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="603" mass="64413" checksum="38720BE5554A980F" modified="2013-05-01" version="1">MFTSALRSRPAWCARSQWQTRALSLTARRRQASPVDGDASGLNAVSKTITQPKSQGASQAMLYATGMTEVDMNKAQVGISSVWFSGNPCNMHLLDLNHKIKESVQKAGLLGMQFNTIGVSDGISMGTKGMRYSLQSRDIIADSIETVMNGQWYDANISIPGCDKNMPGVVMAMGRVNRPSIMVYGGTTAAGCGVQAKNAKLDIVSAFQAYGQFLTGEINEDERSDVIRNAIPHCGACGGMYTANTMASIIELLGMTLPGSSTNPAMSKAKQLEVMAVGPAIRNLLKEDIRPSDVITRDALEDAMVLLNITGGSTNAVLHLIAIAHSVGIDLTIDDFQKVTDRTPFLADLKPSGKYVFQDLHEIGGTPSLIKFLLGEGLLHGDRITATGKTIKENYEKAPSFPESQDIIRPLSNPIKPTGHLCILRGSLAPGGAVGKITGKEGTVFTGKAKCYDAEDLFVEALERGEIKKGEKTVVIIRYEGPKGGPGMPEMLKPSSAIMGAGLGNDVALITDGRFSGGSHGFLIGHVTPEAQAGGPIGLVRDGDTITIDAEKRVIDIIDTTPEELQKRKLEFKAPALKYQKGTLYKYAHIVQDASHGCITDGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M3B1V5</accession>
    <name>M3B1V5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_148966</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761898.1">
        <property type="nucleotide sequence ID" value="XM_016905259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B1V5"/>
    <dbReference type="STRING" id="692275.M3B1V5"/>
    <dbReference type="GeneID" id="27902396"/>
    <dbReference type="eggNOG" id="KOG0409">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035117_1_2_1"/>
    <dbReference type="OMA" id="AGWNAMF"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43060">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43060:SF17">
        <property type="entry name" value="L-THREONATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="1">
        <location>
            <begin position="7"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="2">
        <location>
            <begin position="174"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="2">
        <location>
            <begin position="323"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF13777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="439" mass="46819" checksum="202D7BB057ACFA8F" modified="2013-05-01" version="1">MSSTKPRVGFAGLGAMGGGMAKNLVKEGFEVTGFDVYQPLVDAFVAAGGKPAKTPKEAAQNADVFVSMVANAAQNSSLLFEGEDAVITGLGQGKTFILCSTTPPAFLHELRKRLDDAGRGDIKLLDCPVSGGTIRAANGTLSIFEAGHDQDLDEAAPVLQTMSGNLYRMGNISAGTKTKTIHQLLAAVNIITASEALGLAATVGLNTQAVVDHVNSSDGASFMFENRTPHMLKNDWHPYSALAIIQKDAMIVTDTARRDHFPVPVADTAEQLYFQGEQAGLLRVDDAALVQLYLPKSQGDLVSLASSADVNMAKSHQVSKDTIVHLLAGIHLAGSIEGMAFCKHLGVDRNIMYEIISKAAGWNAMFTRPDTIQAMLANDQWTLADCPAAEQVGHNLSEAVEKCRMLRYPCPMANIALQQYYFAGLAKKTIGKQDRGGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M3B243</accession>
    <name>M3B243_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartate aminotransferase</fullName>
            <ecNumber evidence="7">2.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_125513</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21824"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="EC" id="2.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="7"/>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761968.1">
        <property type="nucleotide sequence ID" value="XM_016901993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B243"/>
    <dbReference type="STRING" id="692275.M3B243"/>
    <dbReference type="GeneID" id="27899130"/>
    <dbReference type="eggNOG" id="KOG1412">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032440_1_2_1"/>
    <dbReference type="OMA" id="GTWTHIT"/>
    <dbReference type="OrthoDB" id="6752799at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006532">
        <property type="term" value="P:aspartate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000064">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000001">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF55">
        <property type="entry name" value="GLUTAMATE OXALOACETATE TRANSAMINASE 1, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="8">
        <location>
            <begin position="59"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF13847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="444" mass="48906" checksum="D8CE9F346B823363" modified="2013-05-01" version="1">MSSAIASTPQHRLEQLQAQLTTMGSNGVASAFSQDVVPLAPEDPLFGLMAAYRKDTDPNKVDLGIGAYRDNNAKPWVLPVVKQADELLRNDPDLNHEYLPIAGLPDFTSASQKLVLGKKSPAIAEKRVISLQTISGTGAVHLGALFLAKFYNPSNAAAKAVYLSNPTWANHNQIFGNVGLPVKQYPYFSKQTKGLDFEGMIGSLKEAPEGSVILLHACAHNPTGVDPTETQWKEIAEVMKAKKHFPFFDTAYQGFASGSLEKDGWAINYFVEQGFELVVAQSYAKNFGLYGERAGCFHFVTSPGSSAVETTQRVGSQLAILQRSEISNPPAYGARIASLVLNDDKLFAQWEEDLRTMSGRIKDMRQAVRSRLEEYQTPGTWHHVTEQIGMFSFTGLNEQQVAKLREKYHIYMTKNGRISMAGLNTNNVEYFAKSLDAVVRESSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M3B2N8</accession>
    <name>M3B2N8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tryptophan--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Tryptophanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_147885</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Trp) + L-tryptophan + ATP = L-tryptophyl-tRNA(Trp) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9671"/>
            <dbReference type="Rhea" id="RHEA-COMP:9705"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78535"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="2"/>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762158.1">
        <property type="nucleotide sequence ID" value="XM_016904575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B2N8"/>
    <dbReference type="STRING" id="692275.M3B2N8"/>
    <dbReference type="GeneID" id="27901712"/>
    <dbReference type="eggNOG" id="KOG2145">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032621_0_1_1"/>
    <dbReference type="OMA" id="SIYHRFM"/>
    <dbReference type="OrthoDB" id="10261385at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000007">
        <property type="entry name" value="Tryptophan--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055:SF1">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055">
        <property type="entry name" value="TRYPTOPHANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF14037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="461" mass="52227" checksum="76CF34D41E38A229" modified="2013-05-01" version="1">MSSTDTPTVGAPPAVAETKDDKKPSSQKIDPYNVAGEVDDSGNVKAIDYDRLIEEFGVQPLSDDILQKFERVTGKSAHLLIRRKIFFAHRDFDKLLDMYEKYGTFMLYTGRGPSSGSMHLGHTVPFLFTKWLQELFDVPLVIMLTDDEKYLYTRHKNKGVTKKGAEVADFIDYAHDNMKDIIALGFDMKKTFIYTDYEFMGGHFLQNVTEYESMVTVNQAQGAFGFDGSTSIGLTAFSAKQGAAAFPSSYPELFGYKDYRLPDLDRTGLRRHKALSQIPVLIPCAIDQEPYFRILRERCKRMKHVHEKPSLILSQFLTALQGPGGKMSASDPNSAIFMSDKPNEIKNKINKHAFSGGRETREEQEKYGGNPDVDVAFTYLSYFLDSDEELQDLADRYRSGKMGTGDMKKRCIAELQKFVAEFQERRSKIDDAKMREFTAYRKLECKGVDAVAEGLKDLTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M3B2T4</accession>
    <name>M3B2T4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_162303</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762213.1">
        <property type="nucleotide sequence ID" value="XM_016907993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B2T4"/>
    <dbReference type="STRING" id="692275.M3B2T4"/>
    <dbReference type="GeneID" id="27905130"/>
    <dbReference type="eggNOG" id="ENOG502QPPH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012260_3_1_1"/>
    <dbReference type="OrthoDB" id="447251at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429:SF9">
        <property type="entry name" value="PAS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429">
        <property type="entry name" value="PROTEIN TWIN LOV 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0157">Chromophore</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAC" evidence="5">
        <location>
            <begin position="306"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="431"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="573"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="442"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="575"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF14092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="594" mass="66122" checksum="06E59915BEFB53ED" modified="2013-05-01" version="1">MPVRASATSSDNAMRGGGELETDHPGLSFDLSPLDDRPGTGGLDMQHTARLRYSDPYQVLLPLQSLVPDNSDAHEAELTSTDDPGSWNVINPAQADLGSGMYSLEQRAELLFSADHLRVILEEPKLLFSLSEFLKVHRPWRLTLLQYYWDAVKALRAMNFARAISDTLSERPLPCIGSAATLPSVTIDARLAEAANEAFDDLVREDLAAYIAHVYTRIVSNSVHRRITGSLATHLREASHGLAEVFVLTDPTRHDQPIILASEEFALTTQYGLRHVIGRNCRFLQGPKTNPHSVRRLAIACAEGKDHMELLVNYRRDGTPFLNLLMIAPLRDSKGIVRYFLGAQVDVSGLLKDVSSLESLRRLVANHTKPEDSCKPAKVNRLQAMKDLSLMLGGDELDVVRQYGGYLNQGYSHLHDTAPPPVMRKERSRILLQGDDEDPTEDDKASSGREDHQEPDITQDMLYKRLESVYKNYLVVRPAPSLRILFASPSLRVPGMLQTHLLHRIGGNSKIRVDFEKSLRTGNAVTARVHWLSVPNRYGDGIGRMRWLHCTPLLHHSGAVGVWVVIVVDEDDESTSSSSRSNSRLVHSPSTSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M3B727</accession>
    <name>M3B727_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_60689</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763758.1">
        <property type="nucleotide sequence ID" value="XM_016909535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B727"/>
    <dbReference type="STRING" id="692275.M3B727"/>
    <dbReference type="ESTHER" id="sphms-m3b727">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="GeneID" id="27906672"/>
    <dbReference type="eggNOG" id="KOG4389">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006586_10_6_1"/>
    <dbReference type="OMA" id="GDMRDEG"/>
    <dbReference type="OrthoDB" id="3200163at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="29"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF15637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="506" mass="55802" checksum="DC9ACA5F5D05928E" modified="2013-05-01" version="1">MVIPSALAPDIGLAGEVVSLLQALPLTQAVLQQSEDCLFINIARPQDQTLRDLPVVLWIHGGGFETGSGASLLGEAAVPGVFYQGNRLVQESIEMGQPIIFTSINYRLAHFGFSASQEMADEGLLNLGIEDQRVAMRWIQQNIRAFGGDPTKVTIMGESAGSWSVSTHLVANNGDHEGLFRGAVGISGGPLKVDPPSRQQPMFDDMAQYVGCGDAADKIACLREAPYELLYAHMNTVNNFLLGFRSLASAWTVRPDGHFIADSPDQLVAAGKIANVPIMYGDMRDEGTLFSLTNQLNITTTELVKDYFKTYWWPNMTEAQLDRLMEEYPEDPTQGSPFGTGLLYAIPSQYKRLAAINGDYSFESQRRQLLAKHTAPKWNYQVEASLPLSDLGSTVLGDLVGGGGLGLTDIPVLGSFHAFDVFFNWFGTLPPELSLNSRHMMGVLVSFIHNLDPNQHGQEDLPEWPQWDAEHLATIRFSETEVDIIRDDYRNASIAFLNEMRDSMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M3B7W3</accession>
    <name>M3B7W3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_61266</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764038.1">
        <property type="nucleotide sequence ID" value="XM_016909556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B7W3"/>
    <dbReference type="GeneID" id="27906693"/>
    <dbReference type="eggNOG" id="KOG4173">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055660_1_0_1"/>
    <dbReference type="OMA" id="CMTPQKR"/>
    <dbReference type="OrthoDB" id="18440at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039258">
        <property type="entry name" value="ZNF511"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21354">
        <property type="entry name" value="ZINC FINGER PROTEIN 511"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21354:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN 511"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF15917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="257" mass="29189" checksum="49DC48ED20504330" modified="2013-05-01" version="1">MAKRVREPSLSIHGSTPEDAPSATVEEAGHTPKYVELEEAALTRTESVFRCLLPPHKAMSFPTYSDYESHYNASHTNRCKQCRRNFPTSHFLQLHLSENHDPIIAVKRERGDKTFACFLEDCDKVCIDWKKRRSHLVDKHHYPKNYDFLVVNNGIDGKWTMLRRGIDSDGHRKSSRARRASSATQATQMTDDTSASQETEETVPDELPMKQRSMDVAKARDEDPALEAVMKSMSSLQFVPRSVTFGKRKGKSGFAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M3BSU0</accession>
    <name>M3BSU0_SPHMS</name>
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        <submittedName>
            <fullName evidence="3">Carbohydrate-binding module family 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_52942</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF09158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016909245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BSU0"/>
    <dbReference type="STRING" id="692275.M3BSU0"/>
    <dbReference type="GeneID" id="27906382"/>
    <dbReference type="HOGENOM" id="CLU_1232492_0_0_1"/>
    <dbReference type="OMA" id="EGPTCCA"/>
    <dbReference type="OrthoDB" id="3156236at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="42"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="2">
        <location>
            <begin position="87"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="2">
        <location>
            <begin position="136"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="2">
        <location>
            <begin position="189"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF09158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="225" mass="23416" checksum="7CB7E353C71B0CFA" modified="2013-05-01" version="1" fragment="single">MITVTEAVTTTAATTITKSSIITVTEADTTAATTSSATAASSAVPLYGQCGGANYVGPTACAAGAVCQFQNPYYSQCVARATNGSTPVIPIYGQCGGAEYIGSGQCTAGSFCRFQDANFSQCVPNALKPTTAPASTVVPLYGQCGGIGYTPTPFCPPRQYCMNPVCAAGSYCQYQNDYYYQCVVAPAYDVLPVYSRCGGFGYNGLTTCEEGSSCTYTNEYYSQCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M3BT33</accession>
    <name>M3BT33_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_110262</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016900838.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="27897975"/>
    <dbReference type="eggNOG" id="ENOG502RGRB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1670142_0_0_1"/>
    <dbReference type="OrthoDB" id="3828405at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004031430" evidence="2">
        <location>
            <begin position="18"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF09825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="189" mass="20903" checksum="37E3CC2EB0C20C5C" modified="2013-05-01" version="1">MKFLTLLAAAMVNVAVADDRGVCKDWHPTIFNRINAFCLKTDIVVPSNYAEKGAGTNPTGRVWITKVGILNGIGCNPPQWVPTGICRRQFYSECASHKMKAYYGRLSCQGWYIQYAPGATKPVKGSDGSTWYVPMKKREALPEAMAEPEAEPEVKMYATKEEAEAAGLAAHEAEEKKARKAKKARRAMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M3BTU7</accession>
    <name>M3BTU7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_151130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758196.1">
        <property type="nucleotide sequence ID" value="XM_016906617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BTU7"/>
    <dbReference type="GeneID" id="27903754"/>
    <dbReference type="eggNOG" id="ENOG502RZJU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095770_1_1_1"/>
    <dbReference type="OMA" id="AMHYVEG"/>
    <dbReference type="OrthoDB" id="8300194at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054208">
        <property type="entry name" value="DUF6914"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21858">
        <property type="entry name" value="DUF6914"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF10075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="109" mass="12067" checksum="FE3759A9852BB4CF" modified="2013-05-01" version="1">MAPTAMVLVRIIVGKVANATRLNSTLRSTPIKGGQPGWNCVVWVKDALEALEKNGRALGTSNTDWSTIRDTAMHYVEGKKAQHRFDGKGNFDLSKVATWDMLERKELVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M3BU65</accession>
    <name>M3BU65_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_127867</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758341.1">
        <property type="nucleotide sequence ID" value="XM_016902177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BU65"/>
    <dbReference type="STRING" id="692275.M3BU65"/>
    <dbReference type="GeneID" id="27899314"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013258_1_0_1"/>
    <dbReference type="OMA" id="NTHEQHI"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001666">
        <property type="entry name" value="MDS1 and EVI1 complex locus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001732">
        <property type="entry name" value="Zgc:162936"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="260"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="288"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="316"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="331"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="636"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="384"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="481"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="517"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="540"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="569"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF10220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="656" mass="70230" checksum="503CBC8264D1AECC" modified="2013-05-01" version="1">MAAAATSSPISAAATTSGVPRTLTSAASGANIPDELENPSLLRPISQKPDPRTSLSPKSDQAHLSPRSTPLPLTGAAAMAEMRRRKQQQTEGSRQTSPNPRVAAMQQLLGTGGMSKPTDAPAPDKMSSPLRKVAEKLSIPNSNAQPENEPEVSPVSLGSFGSTVEGSNAGHAMTATASEQPPGANFVAEPAEMNEGSSYTSQNGSLAVQQQTTDKAISLSYPGPPPPSEGPEGAASRSMTLPGSGFRQGSPKSPATNKRHKCPYCATDFTRHHNLKSHLLTHSQEKPYVCQTCQARFRRLHDLKRHTKLHTGERPHTCDKCGRKFARGDALARHNKGPGGCAGRRSSFGADDEEGDGYDEGMDGVEYDDEGLDEHGRRKSNKRQHLETPQDSDRSVYRQHSSTYPPAPRQMQGSMGPPQVVHPGGTTSPRDISGQPSPAGGSVSSSYYGPGQVFAEPGMMTSSPKPLSPGQPADQHRLSVGDNSAQLGRNRSTSLTTQFQQQHFGRGTGVRSPPQPNNQFLPNSNHQVAPQHNILPPLGSQPQMRNSLQSTASNMMQHPQPYSSTAMGSTPGSLSSHGRSSGSSMRDITGQGHPNPDDIWSYVRTLELRLGRMGDEYELRISRMQEEIISLKGQLGQLSNHASYSSDMARQQGSYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M3BU75</accession>
    <name>M3BU75_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_151222</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758351.1">
        <property type="nucleotide sequence ID" value="XM_016906680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BU75"/>
    <dbReference type="STRING" id="692275.M3BU75"/>
    <dbReference type="GeneID" id="27903817"/>
    <dbReference type="eggNOG" id="KOG0294">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030368_0_0_1"/>
    <dbReference type="OMA" id="KLHQMKY"/>
    <dbReference type="OrthoDB" id="308449at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051959">
        <property type="entry name" value="PAK1-Kinase_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44675:SF1">
        <property type="entry name" value="P21-ACTIVATED PROTEIN KINASE-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44675">
        <property type="entry name" value="PAK1 INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="110"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="479"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="479"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF10230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="508" mass="53625" checksum="4949C177FC3E31FF" modified="2013-05-01" version="1">MAAVSGKRKRVEVVSQQKPVKKAALSQPKNSSATTKFDPQKSSSSKKASSAATNTTTSDGAATSQHPVYIQIVTGSYERVLHGFQARIPQSALKSASQDEKVSISDTFLFAAHASAIRCLAISPSEDADKRLLATGSSDERINVYTLSTAPPPPGARPNLPSLSGVAAAENPRNKSLGSLVHHDRAITKLQFPIKSKLFSSAEDSTIAISRTRDWTMLGSMKAPVPKPQGRPSGDTAAPGEIPAGVNDFAIHPSQKLMLSVGRGEKSLRLWNLTTGKKAGVLNFEVDLLKQVGESKFSSGEGRRVIWDAAGENYVVGFERGAALFGINSKPKAVIKPDRPTKIHQMRFMSLSEKTSLLALSTEDGRILFYDIQSGGEISEGTKQLPQLVCVAQLGGEAAGVSGRIKDFEILDLPGSSLFVTAGSDGAIRLWSVQSSDLGNGAESESTTRQVGALIASHETGDRVTCLGAFLLDGKAQDGMEDAAEDVAEAESNGGAERGSEDGDSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M3BU84</accession>
    <name>M3BU84_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_151233</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">SO2202</strain>
        </source>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GeneID" id="27903824"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="422827at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="SAM_BOI-like_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transcription Factor, Ets-1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PH_domain"/>
    </dbReference>
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        <property type="entry name" value="SAM"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="3">
        <location>
            <begin position="189"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="713"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="620"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="557"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="677"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF10240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="865" mass="94962" checksum="662EBD903B528BCA" modified="2013-05-01" version="1">MQAITPITPLEAGGGEMFQRMKGAASFLEARTAAMRPVSQASEVTEIFDTDFEDESDYGGGGGASAKGSFESYDSRRRSQTTISSYDEARTPSPRTSTQSRPPMELRIEPVSGPRGPHLFRSSQVSAEFDFGYSLQMSPLLPKDTPFQSSRAATAFSEDTITQPRDRSYPLDSPSRQPAYDSHAHIRAWSTQQVIDWMYATEADPSVIECFYIHDIDGSILLNLQFEDLKELDIPSFGKRHQLWNAICTLKGDEGHPSPQPTPFQDISRPCTSHSRQSPTRGRTAAPPAVNDDDDDDEGDEIYSPSQGRGKSRRRGRKATKNTDLITPAESVSIVAIEQLLPKPHKCAKGERCAKWRKQQRELEQLKNEHGIGRFPVSPTKGGHIFVAGNPGNPSTADNIISNVRPQPQSQLQGHLRLEDPFRPVSDAGMQSAGFPSVVASSDVLGPGQLPEFALHEDVLSHLGSRDAQDNVKQFLQFQHVHHQAAENAPPSPPYEMFPSQSISPFPAAIPRHYGAPALVQDVPRQAYTPGPRDHLKHLPKLEIPRSQSAGPQMHHSAITSPPTTDPAATSAMYICRSATASPANISRSATASPGARAEGIYRLGTPSSVVDVPITAVGPPTAPLSRDTSQSVPPNMQYRPQAPLSRAKSRTDPAHWRRPSMALPPVQEGQIFESRPSISTSCSTGSIPTRSSSVRDPAKHSPITRDFGYGPDCSHSGWMRKRKTKMLRHEWTDSHFRLRGTQLTQHASARLSAEVKESINVDDYAVACSSIASNNKLSSALKALAISKGAESKKEVQDATAFAFQLVPSAKEGEERRKRAEGKTHHFAVKTKDERIDWMRELMLAKAREQKEKGFEVEVNGKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M3BVX5</accession>
    <name>M3BVX5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAD4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Outer kinetochore protein DAD4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SEPMUDRAFT_47514</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAD4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016909037.1"/>
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    <dbReference type="AlphaFoldDB" id="M3BVX5"/>
    <dbReference type="STRING" id="692275.M3BVX5"/>
    <dbReference type="GeneID" id="27906174"/>
    <dbReference type="eggNOG" id="ENOG502S890">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="21629at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013959">
        <property type="entry name" value="DASH_Dad4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28222">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28222:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08650">
        <property type="entry name" value="DASH_Dad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="15" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020259"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMF11479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="107" mass="12299" checksum="FC03C5F2AFFA0800" modified="2013-05-01" version="1" fragment="single">QESPHEHQQSQLLSRIITNVEKLNEAIMVLNKSLQEINVQNMNIELVAQMFKNYQSNVLFHLEGMLSTSTASTTNNNKPIPSKPFNIYPTSLYNCTRTCTCTRLRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M3BYR7</accession>
    <name>M3BYR7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_132564</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761337.1">
        <property type="nucleotide sequence ID" value="XM_016902500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BYR7"/>
    <dbReference type="STRING" id="692275.M3BYR7"/>
    <dbReference type="GeneID" id="27899637"/>
    <dbReference type="eggNOG" id="KOG2898">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048121_0_0_1"/>
    <dbReference type="OMA" id="WFRFLWD"/>
    <dbReference type="OrthoDB" id="272512at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063:SF60">
        <property type="entry name" value="LYSOPHOSPHATIDIC ACID:OLEOYL-COA ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063">
        <property type="entry name" value="PHOSPHOLIPID ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF13216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="341" mass="37734" checksum="F1E693E4C016193B" modified="2013-05-01" version="1">MEKYGQYRDKGSGIAPFFPVAPPPSNPLVAPYHVFLFFLRLPFFIFAWAVWLLIVQWTPPGSILRKANLWCIIGIPGIWFVDIRVDGVQRGSLGKTIAKLPTPGSVIASSFTSPVDIVYLAAIFDPIFVQSFPRSRKVKQLSLGAAVLSCFTLDPSPEGSIELSRLMVANPSRTVVVFPEATTSNGRGILRPTPSLLSAGRSTSIFPVSLKYTPSDIVTPIPGWIEVPRFLWKLSSRQTHCIRVRVGLPLTIAQVQRDEDGSREARPRQQNGYDTNYFDSLKAAEATKTDGEPTPAEQKVLDVIVDQLARLGRVKTLGLGLDEKIDFVNAWTGKTKSKKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M3BZI6</accession>
    <name>M3BZI6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyltransferase family 25 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_148745</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 25 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761582.1">
        <property type="nucleotide sequence ID" value="XM_016905124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BZI6"/>
    <dbReference type="STRING" id="692275.M3BZI6"/>
    <dbReference type="GeneID" id="27902261"/>
    <dbReference type="HOGENOM" id="CLU_032992_1_0_1"/>
    <dbReference type="OrthoDB" id="47375at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06532">
        <property type="entry name" value="Glyco_transf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050757">
        <property type="entry name" value="Collagen_mod_GT25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002654">
        <property type="entry name" value="Glyco_trans_25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730:SF53">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 25 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730">
        <property type="entry name" value="PROCOLLAGEN-LYSINE,2-OXOGLUTARATE 5-DIOXYGENASE/GLYCOSYLTRANSFERASE 25 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01755">
        <property type="entry name" value="Glyco_transf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 25" evidence="4">
        <location>
            <begin position="69"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF13461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="411" mass="46627" checksum="67E2896CF8213329" modified="2013-05-01" version="1">MSEKMAFAHSVPPSVTWRDARGSRRVWLTALAALLVLGTLYSFSSHPIPSMHASDALLDTVMNETLGFQKIFVINMHTQRDRQDRMLLAAKLSGIKVEFIDAVTTDQVDENFRNIVPPADKGFDAKKLKDKAYASWRSHVNAIKAIVEQDLGSALILEDDADWDVRLKTQLRDWAIATRQLVQPRMGTTDQYLDPTYSRANYTKYNEPIQKGLNYTEWDIQSPPGQIVPPTDCAYGDLSRWDVLWAGHCGQRLAMPGSECLKTPLGRVAMFDDETAVSTQHFANYWSGSDYKNTYKNHTRLTSWSCAQVCNTAYAISNQGAKRLFYDYSMKRFDGMADAMLRQICDGTHTFDLRTCLSVTPPLFNQYARKGSYFDITPNIRWSTLKNIPQLTEGSTNFIESWPDNSTKRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M3C099</accession>
    <name>M3C099_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HCP-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_148953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761877.1">
        <property type="nucleotide sequence ID" value="XM_016905249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C099"/>
    <dbReference type="STRING" id="692275.M3C099"/>
    <dbReference type="GeneID" id="27902386"/>
    <dbReference type="eggNOG" id="ENOG502QV88">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011273_0_0_1"/>
    <dbReference type="OMA" id="LNGWGIE"/>
    <dbReference type="OrthoDB" id="2384430at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010972">
        <property type="term" value="P:negative regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052945">
        <property type="entry name" value="Mitotic_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43628">
        <property type="entry name" value="ACTIVATOR OF C KINASE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43628:SF11">
        <property type="entry name" value="PROTEIN DSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="572"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="797"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="343"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="446"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="805"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="839"/>
            <end position="855"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF13756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="855" mass="94162" checksum="27790CD82A69F89B" modified="2013-05-01" version="1">MGPRPEHLNLRNGEQSQDEVFDKPRMPFLGRDLPSPRAGEAPPAMSPLDFIAMQGRLLKQQLAEEKKREQQAGRRVSRLDHKVVEQEFRNRPDFFRSISDQSRMTDLAEEEEDMTSPHSHHGGQVATHSPERERPMSFYPTLDRASYITDDGVPEVPVMPTPFFDAQERPSQDPHDAANSAGDYFGIPRALSPEPVEPNVNVQAPSPNVPPSLTNSIDTISSHPRTRTNDSQRSQRSLQSQRSDRERGLAPPQSPRFPRASRSFQSIRSVPPDSGDEDSASANGSQEQPPGRKFSGSSNMSRPQSPYSPWMRPVHRSPSMTSEVSINSSQQQRGPGLTFNNFSRPMSSSGSTPSFDAMRPRPSFESRPSCDQRPGIPYRQASDRSNSTEAAFKPAISRGNSGDSMPAATRVDRNSMHRDDVADVATPSLHAHPTGGFTEDGHMTPGGTSSSSYTSAKPALPRGRAVDRESTAFRDSWIQKQFEWETKHGHVHPHEGRGHERNQSDSPMFDSSNSPALSDGPRVGRTLVMHPNTTRSRSAEPRGKEKQEVAKTSFDRSPLHQSEVASLHYQSEVASLHRSSPSVKTESTDRTIKPLHRKALSADITPEEHLDIGIEAHDAGATNKSTYHLRLAAMAGLPTAMLLYALACRHGWGMRANQAEGVKWLRQAIDSAGMDVANAEEKFNSTSGNGKKLDPAERKKRKAQYALAIYELGISSMNGWGCTKDKALAVRCYEIAGSWGDVDALAEAAFCYTQGVGVKKDVKRAAALYRKAADMGMSMAGNSWIYKAKYMDGANTGTTPVIEAPAKHKVEKKDKKEKAEALPIPEDSRGERPAGGGRSRSRSIWGKRKSEKPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M3C151</accession>
    <name>M3C151_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phospholipase D/nuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_106404</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762142.1">
        <property type="nucleotide sequence ID" value="XM_016900631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C151"/>
    <dbReference type="STRING" id="692275.M3C151"/>
    <dbReference type="GeneID" id="27897768"/>
    <dbReference type="eggNOG" id="ENOG502RYWJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030268_0_0_1"/>
    <dbReference type="OMA" id="MDRASWY"/>
    <dbReference type="OrthoDB" id="2958217at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030572">
        <property type="term" value="F:phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00138">
        <property type="entry name" value="PLDc_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21248">
        <property type="entry name" value="CARDIOLIPIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21248:SF11">
        <property type="entry name" value="PLD PHOSPHODIESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="2">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF14021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="500" mass="56268" checksum="56EE4BB7265BFE16" modified="2013-05-01" version="1">MSSSPSQALATITPLPFTTGLQIYQTSILPAILSAQHEVILITCFWSTASETLARLRETLLQLSEKSHALQQQQQKKKKGKEQQKKIKVRIGFSSSSVWQKLTHTSSKQGKVYSGEEVFGKRGLLSPSSSSLSSSSSSSEKEEKEKELWRGLDLEIKSIFFLPFSVWHPKFVIVDRKEVWLPSCNVSWEEWFEGGVRVQGEGVVRKFVEFWEENWRSEGDGGGEEEEEEGEGEEEEGEEEEEEEEEEEEPDQDQEDQEDQEDFHHHNSPSTTTTTLPNIPYKFLPSPHHRNPHFHLFPWQPPSPAPPTPLNLELLHLFTTAHKSIYIQTPNLTCAPVLDALWGAAVERGVQVTIVTSERLMRVEQLVTAGRTTGWCVRGLVKKYQRAVLERERRMGDLEAGRGGTMGSLRVSYYEPRSGAAAKAKTGGDAEPVQSHLKLTVVDEEAIVFGSGNMDRASWYTSQELGVAFYSHELVTQVMQSLQSALEGRTKLVYDSSTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M3C4K9</accession>
    <name>M3C4K9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_147165</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosducin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763357.1">
        <property type="nucleotide sequence ID" value="XM_016904126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C4K9"/>
    <dbReference type="STRING" id="692275.M3C4K9"/>
    <dbReference type="GeneID" id="27901263"/>
    <dbReference type="eggNOG" id="KOG3171">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053880_0_0_1"/>
    <dbReference type="OMA" id="GIIEMMP"/>
    <dbReference type="OrthoDB" id="70588at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.168.10">
        <property type="entry name" value="Phosducin, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051499">
        <property type="entry name" value="Phosducin-like_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023196">
        <property type="entry name" value="Phosducin_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024253">
        <property type="entry name" value="Phosducin_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46052">
        <property type="entry name" value="PHOSDUCIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46052:SF1">
        <property type="entry name" value="PHOSDUCIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02114">
        <property type="entry name" value="Phosducin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosducin" evidence="3">
        <location>
            <begin position="67"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="117"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF15236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="280" mass="31317" checksum="7212D6F5A42B517E" modified="2013-05-01" version="1">MSGAQDEFKELMRDKERSSAHPEDEHDDARSFLNLSDDSDDDVTPPASAPRASMNGSRSTIPVKRYGANTGPKGVISDAQDFQDSRRTQRASLRSTSSLTSFAQQLSLREQAPAEKIEEEDDLDLEDGDDDGFMEKWRKSRIKDMQTGPKGSQMHRNGNGNSTRLLGSLTMVDPDGYLDAVENSEADTVVIVYIYDDYSQVSDLFERCVRTLAGKHQDTRFVKLHYEDAQMEPMGVPAIIAYRNGDKFAGLVPLINELPDDAELNALTLETVLKRHQILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M3C5U9</accession>
    <name>M3C5U9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NADH-ubiquinone oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_147481</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the complex I NDUFA8 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763777.1">
        <property type="nucleotide sequence ID" value="XM_016904324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C5U9"/>
    <dbReference type="STRING" id="692275.M3C5U9"/>
    <dbReference type="GeneID" id="27901461"/>
    <dbReference type="eggNOG" id="KOG3458">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081931_1_0_1"/>
    <dbReference type="OMA" id="FRTHWQC"/>
    <dbReference type="OrthoDB" id="276296at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010625">
        <property type="entry name" value="CHCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016680">
        <property type="entry name" value="NDUFA8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13344:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13344">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06747">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017016">
        <property type="entry name" value="NDUA8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CHCH" evidence="10">
        <location>
            <begin position="91"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR017016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF15656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="158" mass="18024" checksum="AFFCDE23629105E6" modified="2013-05-01" version="1">MSARQPRFNQQVLIDTTPLPDSIPKVEEIGASSAPLLSASFFIGARCKPYNDDFMHCKTESNGKGESDCLKEGRKVTRCAASVLDDLNKSCLEEFRKHWQCLDHNNQQLWQCRGLERRLNKCAFEKLNLEKKIPGAPENEVPVHLRKKQIYAHSRIGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M3C9I5</accession>
    <name>M3C9I5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_152127</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756601.1">
        <property type="nucleotide sequence ID" value="XM_016907260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C9I5"/>
    <dbReference type="STRING" id="692275.M3C9I5"/>
    <dbReference type="GeneID" id="27904397"/>
    <dbReference type="eggNOG" id="ENOG502RYIG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015534_1_0_1"/>
    <dbReference type="OMA" id="SGHPFTN"/>
    <dbReference type="OrthoDB" id="3524154at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057026">
        <property type="entry name" value="Znf-C2H2_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24537">
        <property type="entry name" value="zf-C2H2_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="498"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="130"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="431"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="637"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="148"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="188"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="225"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="265"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="288"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="372"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF08480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="661" mass="71930" checksum="55C45E4BBD46236F" modified="2013-05-01" version="1">MSGIPDITLNHRRFRSSPHYPSAPAPMTIPRAQEQPVPPPLPPPSYIPISPNHDPGWQWGNDPNASDFGKSASVKPGSSLLGGAQVRAFGGRADRDNIAGYTHTTDWARRGSAISTSTTATITGHINDLVESGSLTPSDDGSMSRPGSDYRLHGERHLEQRTLEASSNTYDKQLLSRIGGPNGPPTPKRSSISYAPANVQETAQLAHAETERRNSQLLRPLSMPERSQQGSLESPASSRWPSSGAISPGFTWSWNDHESGRFQPSRHSSLTFEDSISQRGSYDASMFHQDDPMEDSHMRDLNIRDRQDRSPRSDDHARAGQKRRASSPPRDLTREDRASVSSASVHGEVTHRRSVQQLPRASPISRFHPNHSSVSSASSYGPRHGSLGSSLTGLSIPSSAATSYASGRISPNGLSPAFDPTEARLNAQQLPSSKGFVGPNSAAAPAVQPKSPCGSAPQSRKPSASHLQGVFICECCPKKPKKFDMEEDLRLHESEKQYTCAYCPNRFKNKNEAERHQNSLHLRRHSWSCAALAGVEAAFHSSGAGSGHDICGYCGEEFPNPPQWDMRAEHLNHVHKFGECNQAKKFFRADHFRQHLKHSHQGTSGKWTNMLELACMKDEPLPEKRVVTQAGHAAPSALMVSTNSHSPDAQLGSGIASGESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M3CAS7</accession>
    <name>M3CAS7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_73211</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757036.1">
        <property type="nucleotide sequence ID" value="XM_016910018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CAS7"/>
    <dbReference type="STRING" id="692275.M3CAS7"/>
    <dbReference type="GeneID" id="27907155"/>
    <dbReference type="eggNOG" id="KOG1286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_12_0_1"/>
    <dbReference type="OMA" id="CLAHARM"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000017">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF1">
        <property type="entry name" value="GENERAL AMINO-ACID PERMEASE GAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="319"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="451"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="488"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="53"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF08915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="561" mass="60742" checksum="8E6CC070064EC4E7" modified="2013-05-01" version="1">MATTTASSSDKEVYHNVQEKDVQIVNRSGSEGDASVEAGEVNNPLHRKLESRHMQMIAIGGAIGAGLFVGSGSALQKGGPAALVMGFMIIGVQLFLTMQALAELGVLFPVNGAFFTYACRFVDPSWGFAIGWDYAIGWLAILPFEITAASLTIAFWPSAADINIGVWIAVFLVVLTAVQFFGVRGYGEVEFVLSMVKILACTGFIILGIIINCGGVPTDNRGYIGGKYWQDPGAFRHGFKGFCSVFVTASFAFGGTELSGLAAAEAKNPLKSIPQATRQVFWRIAFFYVVNLFVLGLIVPSDSDVLLNSHGANTKASPFVYAMVLAGIKGLPSVFNVVICLSVLSVANSATFGSTRTLQALAAQGMAPKFLVYIDKHGRPIWSIIIQIAFGFLAFANEATDGGSQFFNWLLALGGLANFFIWGTICLSHVRFRAGWLAQGHTIDQLPFQACFGVWGSYVGIFMNVLCMVATFYTALFPIGGSPNAMDFFETYLAAPFIFALYLGWRFYKHRGSKWYISAQDMDVTSGMRMDIEELREIAAKAQSANAGIASWPKRFVRGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M3CCA4</accession>
    <name>M3CCA4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_110410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758128.1">
        <property type="nucleotide sequence ID" value="XM_016900844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CCA4"/>
    <dbReference type="GeneID" id="27897981"/>
    <dbReference type="eggNOG" id="ENOG502R1DG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_943869_0_0_1"/>
    <dbReference type="OrthoDB" id="3643933at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF10007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="31925" checksum="19A15955E1649B8D" modified="2013-05-01" version="1">MPPKQKSVLDKIRADQAKLRAALAVVKGSAYSRLEEQNAKLRRTAVHSRPVANSSPRPRNVVSKPEVATKVGTKPSANEVVSKPVVELPTKVGTKPSANEVVSKPVVELPTKVSTKPSANKVVSKSEVEPASKVATKPSAYKVVKPPSRKPSVIQRKASIAKKIVTSKKYLDSDDEDSVTESQTESWVPAGGHLPSSTTATGTATNTASKSVGIARIPGWRVEKFTKQLGEFLLMEVVTDDDLFKVRVKTEDEGLEELTDVYVQFETAERAEELRGKIDGKMLDGRMLKVGSGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M3CCD9</accession>
    <name>M3CCD9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_165749</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758173.1">
        <property type="nucleotide sequence ID" value="XM_016908187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CCD9"/>
    <dbReference type="STRING" id="692275.M3CCD9"/>
    <dbReference type="GeneID" id="27905324"/>
    <dbReference type="eggNOG" id="KOG1176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_2_1"/>
    <dbReference type="OMA" id="IPINPIY"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="22"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="452"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF10052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="555" mass="61852" checksum="9A4E0C23111A8166" modified="2013-05-01" version="1">MPSKSTYPDIAIPDVGLWDFLFERKDRDFPDDKVIYVDPATNRSYTYAQTKQTAIDFGKGLKGLWDWQKGDVLALYTPNCIDTPAVTWGTHWAGGIVSPANPGYTVDELAYQLKDSGAKAIITQLAQLEQARLAAKKVGIPEDRIALMGDEKDPAGRIKHFSSVRNISGTQRYRRVKIDADNDLAFLVYSSGTTGLPKGVMLSHRNIVANVSQLTAAESPLKWQPAEGRPDGDAILAFLPFFHIYGLTCLIHQCLYRGLKCVVLPKFDIEAWCRIVQDHKITMSYVVPPVVLLLTKHPIVEKYDLSSLRMMNSGAAPLTRDLVEATHKRIGVPIKQGYGLSETSPTTHTQSWDSWKSSMGSVGAMLPNMTAKYMSPEEKEVPQGEVGELWLKGPNIFKGYLNNVEGTKNAMSEDGYFKTGDVGYQDENGNFFITDRVKELIKYKGFQVPPAELEGYLVSHEKIDDVAVLGVHKEELATEVPLAYVVLKQGIDASPSVEKEIVEWLNAKVASHKKLRGGVKFTEEIPKSVSGKILRRMLKVKHQEEEAKKNRRAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M3CEB5</accession>
    <name>M3CEB5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial zinc maintenance protein 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_150334</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Assembly factor required for Rieske Fe-S protein RIP1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane. Modulates the mitochondrial matrix zinc pool.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with RIP1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I LYR family. MZM1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759512.1">
        <property type="nucleotide sequence ID" value="XM_016906100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CEB5"/>
    <dbReference type="STRING" id="692275.M3CEB5"/>
    <dbReference type="GeneID" id="27903237"/>
    <dbReference type="eggNOG" id="ENOG502S6EF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147114_2_0_1"/>
    <dbReference type="OMA" id="KYKLRIH"/>
    <dbReference type="OrthoDB" id="529194at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20267">
        <property type="entry name" value="Complex1_LYR_LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045298">
        <property type="entry name" value="Complex1_LYR_LYRM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050435">
        <property type="entry name" value="MZM1/LYRM7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46749">
        <property type="entry name" value="COMPLEX III ASSEMBLY FACTOR LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46749:SF1">
        <property type="entry name" value="COMPLEX III ASSEMBLY FACTOR LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF11391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="130" mass="14335" checksum="40A19C5485BCEA10" modified="2013-05-01" version="1">MASQALSRAEIATNRFAVLATYRHLLRATKIAFSEDDIMLRTSRAFARSEFRTGAKLIPNGPEAAQGVEHAQGVAQILRENVVQGVKVGEVGEKYKLNIHEHTQRLDNDTAGKLKGTTKSFKEVKSESLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M3CIP6</accession>
    <name>M3CIP6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_27442</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761804.1">
        <property type="nucleotide sequence ID" value="XM_016908426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CIP6"/>
    <dbReference type="GeneID" id="27905563"/>
    <dbReference type="eggNOG" id="ENOG502SWNK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099493_2_0_1"/>
    <dbReference type="OMA" id="YLHARHR"/>
    <dbReference type="OrthoDB" id="5400539at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020999">
        <property type="entry name" value="Chitin_synth_reg_RCR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12273">
        <property type="entry name" value="RCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF13683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="123" mass="14248" checksum="CB36C9EFD8F56523" modified="2013-05-01" version="1" fragment="single">DYGDHESWWWSDTGMAVRYAVICVIFAAILLYFLGGYWHARHRLSKGQPPLAYHRWMVNRTVRYQQPQHQAAPYRPYQHGPDPYQEGYVMHRYAPPPPAYHGDAPPAYAPPEGASKAMADQNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>M3CJN6</accession>
    <name>M3CJN6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_81885</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762154.1">
        <property type="nucleotide sequence ID" value="XM_016910293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CJN6"/>
    <dbReference type="STRING" id="692275.M3CJN6"/>
    <dbReference type="GeneID" id="27907430"/>
    <dbReference type="eggNOG" id="KOG0055">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_17_2_1"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000913">
        <property type="entry name" value="ABC multidrug transporter SitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000251">
        <property type="entry name" value="ABC transporter B family member 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF1">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="699"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="747"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="818"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="929"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="961"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="59"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="384"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="703"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1025"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF14033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1271" mass="137378" checksum="1E127371E8E4984F" modified="2013-05-01" version="1">MINGGGLQQQQQIHQEKPANEKSDEDSVLQSQIAAPENWPSPGQFFWSCTSKSDRLVLVIATIGAVVGGAASPFSVVLLGFGGESFRGYFTGETTKTELLEGINRLTLLYLCLAIVTLVAIYIATVGFTLAGERISQRIREKYLAAVLRQNIAYVETLGVGEVNKQLTTDVYLIQEAITGKAAALITALGTCISALIISFIKSWLLALVIIPAELVIVASMSTGAAFMIKYTKQAVAAYTLAANISDEALGSMRTVAAFGMQRSLVHRYATHIAVARAAGIRSGVALACMIAALNSIIWWTYGLAFWQGSRFLVQDKVSLSAIITVLFVTISGAFALGNVSPHAQAFVDGIMAADKISQMISRQSPVDSSSSTGYTLPRVAGAVEFKHVRHVYPSRPEVLVLDDFSLTFPPGTTTAIVGHSGCGKSTIVDLLERLFLPTSGSIYIDGHDTSKLNVSWLRQQIGLVGQEATLFSTTIFENIRYGLVGSESEHLPVEAIRHLVEEAAKTANAYDFISKLPEGFDTKVGDCGSLLSGGQKQRIAIARAIVRHPKILVLDEATSALDGNAERLVQEALQQAAIGRTTIAIAHRLSTIADADNIVVLSKGTIVEQGTHQALMQKGELYCQMVGNQNMQAAMPHALESDKTLTKQETLPKVVTMEVSSDFGHESGSQPDSKPSAAVSIWSLGLFVFRLNSKDLPLILCGLGFSIMAGASFPTQAVFMAEIFTAMSVGRSRYDELRSQVNYWCWFYLMIGFTTAIGWLGQGVCLTFYSQELTYRTREKGLDTILHHDMSAFLQDDHTVAALSKALSSSSSHLEGLGGSLGGTILVVCTQLIAGLALGLAVGWKLALVCACTIPVQLVCGALRLKCLALLEAHGRKVYAASAAYACEYSTNIRTVATLTLEKDIQQNFHRILETQRKRSLVSTSHSALLYAVSQSVTFMCAALAFWYGNRMIVNEGYTMFQFFVCYAAIVEGSFSAGAIFSFAPDMGKAKEAARELKALFELPVNIDARGDTGYTSPEVDGSVSLRGVSFRYPNRPEHLVLDKIDLEVSPGQYVGLVGPSGSGKSTIIALLERFFDPEEGQVMVQGTNVRNWNVKNLRSHVALVNQTPTLFDGTIYQNIAKGVEDEGPSEEDVVQACKDANIHEFVRSLPFGLNTLVGARGTMLSGGQKQRISIARALLRNPKILLLDEATSALDSESEKVVQVALDAAARGRTTIAVAHRISTVRNADCIYAVLDNGRIVETGTHDDLMEIKGKYYDMVQLQSLDQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M3CJW5</accession>
    <name>M3CJW5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">General transcription and DNA repair factor IIH subunit TFB5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_115397</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.</text>
    </comment>
    <comment type="function">
        <text evidence="9">In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the 7-subunit TFIIH core complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the TFB5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762224.1">
        <property type="nucleotide sequence ID" value="XM_016901157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CJW5"/>
    <dbReference type="STRING" id="692275.M3CJW5"/>
    <dbReference type="GeneID" id="27898294"/>
    <dbReference type="eggNOG" id="ENOG502SBQE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_166246_3_1_1"/>
    <dbReference type="OMA" id="IYNPMDE"/>
    <dbReference type="OrthoDB" id="354at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006294">
        <property type="term" value="P:nucleotide-excision repair, preincision complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1220:FF:000002">
        <property type="entry name" value="RNA polymerase II transcription factor B subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1220">
        <property type="entry name" value="TFB5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035935">
        <property type="entry name" value="TFB5-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009400">
        <property type="entry name" value="TFIIH_TTDA/Tfb5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28580">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28580:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06331">
        <property type="entry name" value="Tfb5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01395">
        <property type="entry name" value="Tbf5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142897">
        <property type="entry name" value="TFB5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF14103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="73" mass="8332" checksum="537A0E043B51A9AA" modified="2013-05-01" version="1">MPRAMQGVLVQCDPSIKAIIVRIDAQHAHSFIIEDIDDEHVLVNQKKHDELKALLKDTLKDTVREPEESSEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>M3CMR8</accession>
    <name>M3CMR8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Adenylate kinase</fullName>
            <ecNumber evidence="6">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate kinase cytosolic and mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ADK1</name>
        <name evidence="9" type="ORF">SEPMUDRAFT_147073</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <text evidence="6">Predominantly mitochondrial.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the adenylate kinase family. AK2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="6"/>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763229.1">
        <property type="nucleotide sequence ID" value="XM_016904067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CMR8"/>
    <dbReference type="STRING" id="692275.M3CMR8"/>
    <dbReference type="GeneID" id="27901204"/>
    <dbReference type="eggNOG" id="KOG3078">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032354_1_0_1"/>
    <dbReference type="OMA" id="VYHEQTA"/>
    <dbReference type="OrthoDB" id="439792at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006172">
        <property type="term" value="P:ADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000106">
        <property type="entry name" value="Adenylate kinase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03168">
        <property type="entry name" value="Adenylate_kinase_AK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028587">
        <property type="entry name" value="AK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001380">
        <property type="entry name" value="PRK00279.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001381">
        <property type="entry name" value="PRK00279.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011100">
        <property type="entry name" value="PRK14527.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adenylate kinase active site lid" evidence="8">
        <location>
            <begin position="165"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMPbind" evidence="6">
        <location>
            <begin position="67"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="6">
        <location>
            <begin position="164"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="47"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="94"/>
            <end position="96"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="123"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="174"/>
            <end position="175"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF15108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="269" mass="29564" checksum="A1057F77DF987766" modified="2013-05-01" version="1">MSAETVETLKATIDKLERKVHELESRITGHGSSSNDGMRMILIGPPGAGKGTQAPKIKEKFGCCHLATGDMLRAQVAAKTELGKQAKKIMDQGGLVSDEIMIGMIEKELENNKECSGGFILDGFPRTVPQAKKLDQMLEAKTQPLKHAVELEIDDNLLVARITGRLVHPASGRSYHKIFNPPKKEMTDDVTGEPLIQRSDDNEVALKKRLSTYHAQTAPVVDYYRTTGIWKRIDASQDPGAVWKNMLQIFKESDKSTSGGLLGKLGLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M3CMW9</accession>
    <name>M3CMW9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_147115</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763274.1">
        <property type="nucleotide sequence ID" value="XM_016904090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CMW9"/>
    <dbReference type="STRING" id="692275.M3CMW9"/>
    <dbReference type="GeneID" id="27901227"/>
    <dbReference type="eggNOG" id="KOG1944">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066033_0_0_1"/>
    <dbReference type="OMA" id="KMAIYGA"/>
    <dbReference type="OrthoDB" id="860at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF93">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN 25D9-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="230"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="232"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF15153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="28138" checksum="F998C680A60B160C" modified="2013-05-01" version="1">MSQVKFEQKESIRTTTGGRPGPSPAAGKEDVAHKIGDALTKGSGPNGYLAWYLKKLQDDPLKTKMVTSGALSGAQEFLASWIAKDRSKHGHYFTSRVPKMAVYGAFISAPLGHVMISILQKLFAGRTSLRAKILQILVSNLIIAPIQNAVYLTSMAVIAGARTFHQIRATVKAGFMPVMKVSWITSPIALAFAQAFLPNEVWVPFFNVVGFIIGTYINAHTKKKRLQALRRKYQDSSRPSDGRSDYRPGDQGPPGSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M3CNT1</accession>
    <name>M3CNT1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">CDP-OH_P_transf-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_147312</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763544.1">
        <property type="nucleotide sequence ID" value="XM_016904221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CNT1"/>
    <dbReference type="STRING" id="692275.M3CNT1"/>
    <dbReference type="GeneID" id="27901358"/>
    <dbReference type="eggNOG" id="KOG3240">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067602_0_1_1"/>
    <dbReference type="OMA" id="GISFPIM"/>
    <dbReference type="OrthoDB" id="10251079at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003881">
        <property type="term" value="F:CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000011">
        <property type="entry name" value="Cdp-diacylglycerol-inositol 3-phosphatidyltransferase pis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362:SF4">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--INOSITOL 3-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="177"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF15423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="302" mass="33857" checksum="1A817B63F2F46882" modified="2013-05-01" version="1">MVQDVVDEKELAHANEFIQNGHPKPSGGVAHDDDEETNENIFLFIPNLIGYSRIVLAIASLYFMPLHPRRCSFLYSISCLLDAADGIAARKYEQSTRFGAVLDMVTDRCTTTCLLVFLATAKPAYSVIFQLLISLDLASHYMHMYATLVMGGQTQSHKNVDAKRSWIMNLYYTNKTVLFVACALNELCFIGLYLLCFSSPLITPALRLPTETTPTSPLQPTPSLLFSNPFSAAAMEYARANKMDSNIPWFIFAASAPVMLFKQYVNVVQLVQASRWLAEGDRKDRKKLGLPRKKGIRARKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M3CP62</accession>
    <name>M3CP62_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_60540</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763689.1">
        <property type="nucleotide sequence ID" value="XM_016909529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CP62"/>
    <dbReference type="STRING" id="692275.M3CP62"/>
    <dbReference type="GeneID" id="27906666"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_19_1_1"/>
    <dbReference type="OMA" id="RWHKANW"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF236">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G12060)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="24"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF15568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="431" mass="48183" checksum="48A78D29D95E34C9" modified="2013-05-01" version="1">MAPFMNGNDSSNQQDGPVPSSGIRVVIVGAGFAGLTAAIECTRKGHSCIILDSVKEMKQLGDIISFGGNGGRIFQRWPGVAEKLDPICHHAPVIEFRTWLGEHIYTQEWEAEEVFGKRFNGHRGEIHQVVYDYALAQGIEIRLGQQVTEYFENEDLAGVISNGERIVGDVVFGADGVKSKARQLILGYDDKPKPSGYAVYRAWMSSEELAKNELTKDLVIHGDTHTGWLGRDIHFLASALKNGTEMSWVFTHKDDRDVDEGWSEPGNHEDACRILEGWDPIVHTMVKLTPPDKMVDWKLVYRDPLPTWVSPEARTVLIGDAAHPFLPTSIQGAAQAMEDGACLAVCLQLSGKEKARDALRAYEKIRYERVKYAQKTGETTRDRWHKADWEAVKLNPESIKLVRDPELLKHDAEAHAYKMYAQAVASPHNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>M3CPD8</accession>
    <name>M3CPD8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_147451</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763739.1">
        <property type="nucleotide sequence ID" value="XM_016904307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CPD8"/>
    <dbReference type="GeneID" id="27901444"/>
    <dbReference type="HOGENOM" id="CLU_2051111_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF15618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="120" mass="13349" checksum="B7B0D09636ECB2D5" modified="2013-05-01" version="1">MRSLDAGKRVLRVMIEQLKLLHWAGLAGWAGLPLLRRRSAGRKVASLQRAARMHDHGRCRVHTVYSVCIGLYGEYMSQARLGSTVGLSARRWRLEGRRAGGRTGGRAVKCSREQGCCDCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M3CQ92</accession>
    <name>M3CQ92_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_10484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763979.1">
        <property type="nucleotide sequence ID" value="XM_016900555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CQ92"/>
    <dbReference type="STRING" id="692275.M3CQ92"/>
    <dbReference type="GeneID" id="27897692"/>
    <dbReference type="eggNOG" id="ENOG502S7CI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1801186_0_0_1"/>
    <dbReference type="OMA" id="MFGSHWI"/>
    <dbReference type="OrthoDB" id="5320532at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008402">
        <property type="entry name" value="APC_su15/mnd2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05841">
        <property type="entry name" value="Apc15p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF15858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="153" mass="17480" checksum="E0B5BB254B66423D" modified="2013-05-01" version="1" fragment="single">MFAFPLIPPQEDPSSFLRTAYRPRAESPPPQAGQNQQQAHRERQRRDEERKLHHARSPLALLAADENAIEARKNAVRMFGSHWIRPPGVAKTLQAQEEEIAERLEQDELERQERGIADMQAQQQQAEAEAEAEQHAAAEEAGELEEERDLDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M3CVD0</accession>
    <name>M3CVD0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SEPMUDRAFT_129090</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF08107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756228.1">
        <property type="nucleotide sequence ID" value="XM_016902256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CVD0"/>
    <dbReference type="STRING" id="692275.M3CVD0"/>
    <dbReference type="GeneID" id="27899393"/>
    <dbReference type="eggNOG" id="KOG1164">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019279_2_7_1"/>
    <dbReference type="OMA" id="IFDWTFL"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14125">
        <property type="entry name" value="STKc_CK1_delta_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000159">
        <property type="entry name" value="Casein kinase I hhp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000538">
        <property type="entry name" value="Putative Casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="12"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="310"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="325"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMF08107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="353" mass="40316" checksum="B45C8D54940D0CF8" modified="2013-05-01" version="1">MTTMDLRVGNKYRIGRKIGSGSFGDIYLGTNIISGEEIAIKLESVKAKHPQLEYEARVYKSLAGGVGIPFVRWFGTECDYNAMVLDLLGPSLEDLFNFCNRKFSLKTVLLLADQLISRIEYIHAKSFIHRDIKPDNFLMGIGKRGNQVNVIDFGLAKKYRDPKTHFHIPYRENKNLTGTARYASINTHLGVEQSRRDDMESLGYVMLYFCRGSLPWQGLKAATKKQKYDRIMEKKMTTPTEVLCRGFPNEFAIYLNYTRSLRFDDKPDYSYLRKIFRDLFVREGFQYDYVFDWTVYKYQKNAQAIAQAAGNQNAADDTEEKPGRRTGAATRGTTGQLSKDRSGAVPPREGTGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M3CVN3</accession>
    <name>M3CVN3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_75002</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF08202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756323.1">
        <property type="nucleotide sequence ID" value="XM_016910090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CVN3"/>
    <dbReference type="STRING" id="692275.M3CVN3"/>
    <dbReference type="GeneID" id="27907227"/>
    <dbReference type="eggNOG" id="ENOG502SUA0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085444_0_1_1"/>
    <dbReference type="OMA" id="STKSPFM"/>
    <dbReference type="OrthoDB" id="5416589at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000171">
        <property type="term" value="F:ribonuclease MRP activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034965">
        <property type="term" value="P:intronic box C/D snoRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000294">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, RNase MRP-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.20">
        <property type="entry name" value="Alba-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036882">
        <property type="entry name" value="Alba-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014612">
        <property type="entry name" value="Pop7/Rpp20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020241">
        <property type="entry name" value="RNase_P/MRP_Pop7_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28256">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28256:SF1">
        <property type="entry name" value="RIBONUCLEASES P_MRP PROTEIN SUBUNIT POP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12328">
        <property type="entry name" value="Rpp20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF08202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="228" mass="25890" checksum="AEB545A0531017FF" modified="2013-05-01" version="1">MADTVSTGRITKRHKQRPSKTGHKLPSLPSDAQITKRPLLRPAIPSPYSGPSQQKIVYISAKTPFMSAVKRAEKLLHLSDKRLVQSATQLSKDARNKKRRWERREDEDEIREEVVLKGTGKAIGKVMELGLWFQQRDAEYHVRLKTGSVFAVEDVQYEEEAEKHASAGAQVTEDVVQAASSYEIKQAVAKPMSKVMKREEHEAENGKKEISETRIRQLSVLEVYISLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M3CW46</accession>
    <name>M3CW46_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_11882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456288">
        <property type="protein sequence ID" value="EMF07896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CW46"/>
    <dbReference type="eggNOG" id="ENOG502SCZA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3038406_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF07896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="51" mass="5415" checksum="F28BA4FC0D37A888" modified="2013-05-01" version="1" fragment="single">SGALLTTLENPPEGMIFTPGRTHNRSRSPSRQNRSVTSGKGLALRVGRVGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M3CW69</accession>
    <name>M3CW69_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_152069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756508.1">
        <property type="nucleotide sequence ID" value="XM_016907224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CW69"/>
    <dbReference type="STRING" id="692275.M3CW69"/>
    <dbReference type="GeneID" id="27904361"/>
    <dbReference type="eggNOG" id="KOG1243">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010392_1_2_1"/>
    <dbReference type="OMA" id="NDTSWAG"/>
    <dbReference type="OrthoDB" id="447103at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984:SF3">
        <property type="entry name" value="N-TERMINAL KINASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="405"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="439"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="570"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="596"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF08387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="606" mass="65157" checksum="3E1541DC7DA4A7E5" modified="2013-05-01" version="1">MKEDDAIIFTQGSLVPDIGRYSPPEVVKNGWDSVRSNPLHAVDSYNYGILVTEVFSGGFSGTDQVGSIKNIPTNMQNSYKRLTHAAPKMRLSIAHFLDQGTRSGGFFDTPLIQLTDGIDNMGLKSASEKDTLFSELEQLVGTNEFPEDFFLVKVLPELLKSVEFGGGGPRPFALAMRIAPKLAEDEYTLQITPIIIRLFASSDRALRVCLLDNLPNMIDHLSQKVVSDKIFPQMVTGFGDLAPVVREQTVKAVLVVVPKLSDRIINGELLRHLAKTANDEQPGIRTNTTICLGKIARNLAASSRAKVLTAAFSRALRDPFVHGRNAALMALAATADIFSEEDCATKMLPAICPSLVDKEKMIRDQANKTLNIYLDRVRKHQTTMPDTVLPPPEISSAGPTRMSTPQPGQQAGSGWAGWAISSFTNKISAVAGEIQPNGTGAAPTAAEVAPPTSNGVPRPAYNSTLSAPVVPKVSSGLRTSAPVTPADEEDFGNSGWEEMNDNEAPVEDDPWAESTAPKSMTSYDDGGEPDFEGWLNAQAQAKKTSKAPLPKGLTKKTAPAAKSSPVGRPTISATSRSSAATNKPVIAKPKPKPVQEESDDWGDAWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>M3CWU2</accession>
    <name>M3CWU2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_129118</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF08146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756267.1">
        <property type="nucleotide sequence ID" value="XM_016902258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CWU2"/>
    <dbReference type="GeneID" id="27899395"/>
    <dbReference type="HOGENOM" id="CLU_2832819_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF08146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="66" mass="7728" checksum="87473B9572D9A552" modified="2013-05-01" version="1">MNFSWRQIAHRELSQHRANASRLPLQVWKKTHVVVIGSREYMYFGFRLGGMLGEEAISCKVNLNKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M3CXK4</accession>
    <name>M3CXK4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_136181</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756953.1">
        <property type="nucleotide sequence ID" value="XM_016902760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CXK4"/>
    <dbReference type="STRING" id="692275.M3CXK4"/>
    <dbReference type="GeneID" id="27899897"/>
    <dbReference type="eggNOG" id="ENOG502S68B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109055_0_0_1"/>
    <dbReference type="OMA" id="WWDKKPI"/>
    <dbReference type="OrthoDB" id="2400485at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34213">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2 (NTF2) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34213:SF2">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2 (NTF2) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF08832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="180" mass="20041" checksum="7471CB3EAA889D3B" modified="2013-05-01" version="1">MNTTLTGRQPSANEKTIIDEVLSLYQLKPTEKSYSHYRSDAVFHDPVSIAKGKESIMSQFNGMPKLFSSSETQKCEILDPAQATRQSSAASTHAGEGGAIVLDLTQHYVFKGEKTPEKTLNSKITLQLDGEGMIQHHEEEWDHTKNKTGEDGFMGKLQEWRKKADAKLVEMGVSSDPKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M3CXP1</accession>
    <name>M3CXP1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_26466</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756542.1">
        <property type="nucleotide sequence ID" value="XM_016908412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CXP1"/>
    <dbReference type="STRING" id="692275.M3CXP1"/>
    <dbReference type="GeneID" id="27905549"/>
    <dbReference type="HOGENOM" id="CLU_2114829_0_0_1"/>
    <dbReference type="OrthoDB" id="4159781at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF08421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="115" mass="12897" checksum="362BC022C35639A7" modified="2013-05-01" version="1" fragment="single">QEPALYYARLLFTAGHLLETGVVRPRLCDVLKQKTTAAVHDSLTSDRHASNGLILAVGSLAFYESMYGSEPQIVHHLHRPAQRRMIQFRGGLDSLNLPEIVKAAMRWEDAVMTLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M3CYM5</accession>
    <name>M3CYM5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_119503</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF09759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757880.1">
        <property type="nucleotide sequence ID" value="XM_016901514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CYM5"/>
    <dbReference type="GeneID" id="27898651"/>
    <dbReference type="HOGENOM" id="CLU_1120708_0_0_1"/>
    <dbReference type="OrthoDB" id="10636205at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF09759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="27422" checksum="BDEA9BC041E0D8F9" modified="2013-05-01" version="1">MALLAIFKQICANLKRRLSSLKPGQDLNETQPQPPSERECNICCEVQPDSAFPRSHHLPESCRPCLLGSGGGGGEDITAAASGQNNTTTTTATTTTTTTTTNATQLICNVCLARALYAQIESKHPRRIGCPVCPQIWKPGMTVYQLLGYGEQGKDWKRAYRMRLKEVSSKSKRKRAGVYEPPEDRKTLEVLVKQDSRLCPYCAGVFYRGSGCDWMRCGSCSRSFALEKAGTIAEAHRDWLRKKKASKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M3CYW0</accession>
    <name>M3CYW0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_150962</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF09849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757970.1">
        <property type="nucleotide sequence ID" value="XM_016906505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CYW0"/>
    <dbReference type="STRING" id="692275.M3CYW0"/>
    <dbReference type="GeneID" id="27903642"/>
    <dbReference type="HOGENOM" id="CLU_1587518_0_0_1"/>
    <dbReference type="OMA" id="MRFTYIA"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032936" evidence="2">
        <location>
            <begin position="19"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF09849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="168" mass="15337" checksum="13C642953450447C" modified="2013-05-01" version="1">MQFKQLILLTAPFALVEAQIAGAITSAVGGDLTSAVGGVASSAISGVTGAASSVTSGAEGAESSATSGAESAMSTASESASDAASSLSSSASSAESSASSAESSATSSARSAESSATSGGVGGIVGSATSRLGGAASSATSDGAAYETQAPKIAAGLLAMGMGAVALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>M3D0E2</accession>
    <name>M3D0E2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_134237</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF10998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759119.1">
        <property type="nucleotide sequence ID" value="XM_016902626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D0E2"/>
    <dbReference type="GeneID" id="27899763"/>
    <dbReference type="HOGENOM" id="CLU_1788016_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF10998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="145" mass="16648" checksum="6C6BA50E4D0E9DC9" modified="2013-05-01" version="1">MPKGLAGMVIRWPGNDGVFGSFTAVDFDVVRGVQDVLQRSARDQEPFCPHRLPSFASRRLVKRTTRLIHYYCFYTQERVSLYERKRGCSRTAIEAKLLSKWSAFGIWVIQAHAKQPGPIAMRHKGTASVVTPYRHKNAFTTCQFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M3D0R7</accession>
    <name>M3D0R7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_119804</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SO2202</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2012-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genome evolution in poplar pathogens from wild and recently domesticated pathosystems.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Dhillon B."/>
                <person name="Feau N."/>
                <person name="Sakalidis M.L."/>
                <person name="Gill N."/>
                <person name="Aerts A."/>
                <person name="Ohm R."/>
                <person name="LaButti K."/>
                <person name="Pangilinan J."/>
                <person name="Lindquist E."/>
                <person name="Copeland A."/>
                <person name="Beauseigle S."/>
                <person name="Grigoriev I.V."/>
                <person name="Goodwin S.B."/>
                <person name="Tanguay P."/>
                <person name="Hamelin R.C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758199.1">
        <property type="nucleotide sequence ID" value="XM_016901544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D0R7"/>
    <dbReference type="GeneID" id="27898681"/>
    <dbReference type="eggNOG" id="ENOG502T17S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_792660_0_0_1"/>
    <dbReference type="OrthoDB" id="3902367at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF10078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="350" mass="37964" checksum="711C83A1E56349FE" modified="2013-05-01" version="1">MSSTTRVPLLTQAIEEGVVDLVGINEVKFLEFRRPAPREILSLGARGLSACSIIVVASDKAAIVAHIGPNIPDSTQQDSFLRLAHSKMDELETKYRERVHLFSNSSQTYVIYATFQRVQTSPEQVDIFRERLNTFGLRMIKESSYERSPASLMNKNRPEGTVWVVRPDPNRPTVVYVEDKIVSPASAGKIAAVGSSSSQSMAESPAATLGAGAVESSRQAQLANIPLQQARARRDQLISQGQSPAQAIAALQSTLAKMLNISEAEAYAELRVDNVAGYGRGTAPEAASGEETGRGGRRAEIDTVRIHQAKARRDQLVALGMTRQQAIAQLQKVLAQMLDISEAQASALLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M3D1G2</accession>
    <name>M3D1G2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">L domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_10214</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF10977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759098.1">
        <property type="nucleotide sequence ID" value="XM_016900506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D1G2"/>
    <dbReference type="STRING" id="692275.M3D1G2"/>
    <dbReference type="GeneID" id="27897643"/>
    <dbReference type="eggNOG" id="KOG0472">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007408_0_0_1"/>
    <dbReference type="OMA" id="SWQIKSG"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="234"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="264"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="917"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF10977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="917" mass="98948" checksum="7A81B9E9910F431B" modified="2013-05-01" version="1" fragment="single">ATDDEEKHDKLSSLDSFRSASRQGFEDELPGGSPEYAESTQAQDAAAPQRRHPRPSLSERTIESLQSVPSTPNERRRSGFFNPPDSPMGPPPRPTSAMSRNGRSGSRPGTSDGSTSSRPLSRAGSTRIAPASAKPFTRTTTKTASRISSLPATHTTKQSIGGGGGLTSRLQQARVDAQRATSPVKKPSALPNASSIGIPKTSLTKMGNGTRTIASSRPAKPRPALGDAFVSPAKRTSATKPALSVSTNEAEPSEGKRAISNSSAALREQIAAAKAAARKHKEAATKRESDSSQPQVTSDETAIAADDHADPFGQAPKDEKHVLKYRVHNARMSGKLNVAAMGLKEMPEEIRTMYDAKTMEDSKVNWAEVVDLTKFIAADNDFEVIDESVFPDRSHEELAEDEDAQGNQFGGLELLDLHGNSLSALPMGLRRLDRLAHLNVTHNKLENTVIDIIAQIPTLKELRLGNNNLTGNLPSAICSLTKLEVLDVGTNRLLGLPEALVDLVGLRVLNVSGNQLTTLPMEALVQIPLTELDASSNALIASLFPLGGPSGHSTLQSLNVANNSLAALTFSEALEMPKLRELYLTNNQMTSLPSVSGWSELMTLHAGDNKIVDFPEGFTSLSKLRNANFTSNELRMLDPEICRMANLDSLVLAANPLREKKFLTMNAADIKRDLRAKIAPGSGGDFDDEEPTSPVTVVGAEDQTSQWSVKGNGLLSLSGKDLADDLDEDLSSFLRSNSVRQLQLPDSGITVIPPVLSLVQDLRSLDLSGNSLGTEYLTDEITLPTLEELNLSKCRIQSLDLLMTFLQAPNLKTLHLTANRLSGDLPALRTVYPQLTTLFATDNKIRTISADALRGLHTVNLASNDIEALPAEIGLLWDEGLRNFNVSSNAFRVPNYRLLDKGTEATLRWLRDRLPNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>M3D1J1</accession>
    <name>M3D1J1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_126625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759123.1">
        <property type="nucleotide sequence ID" value="XM_016902088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D1J1"/>
    <dbReference type="GeneID" id="27899225"/>
    <dbReference type="HOGENOM" id="CLU_3107931_0_0_1"/>
    <dbReference type="OrthoDB" id="3629819at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF11002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="51" mass="5554" checksum="5EB59EF09B18D74D" modified="2013-05-01" version="1">MGTFCIDKRSSAELSNAIKPMCQRDALSAVCLVFLPEVHELGITEIADVCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M3D311</accession>
    <name>M3D311_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sterol 3-beta-glucosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.173</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Autophagy-related protein 26</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">SEPMUDRAFT_149236</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26 27">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="23">Sterol glycosyltransferase responsible for the glycosylation of ergosterol to form ergosterol-glucoside.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>a sterol + UDP-alpha-D-glucose = a sterol 3-beta-D-glucoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22724"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15889"/>
            <dbReference type="ChEBI" id="CHEBI:37424"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.173"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:22725"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>ergosterol + UDP-alpha-D-glucose = ergosteryl 3-beta-D-glucoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61836"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16933"/>
            <dbReference type="ChEBI" id="CHEBI:52973"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:61837"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Preautophagosomal structure membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.173" evidence="4"/>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760736.1">
        <property type="nucleotide sequence ID" value="XM_016905433.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.M3D311"/>
    <dbReference type="GeneID" id="27902570"/>
    <dbReference type="eggNOG" id="KOG1192">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000537_6_0_1"/>
    <dbReference type="OMA" id="WRNKTLG"/>
    <dbReference type="OrthoDB" id="10261837at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016906">
        <property type="term" value="F:sterol 3-beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13215">
        <property type="entry name" value="PH-GRAM1_AGT26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13216">
        <property type="entry name" value="PH-GRAM2_AGT26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000303">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000391">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000029">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000009">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048066">
        <property type="entry name" value="ATG26_PH_GRAM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048065">
        <property type="entry name" value="ATG26_PH_GRAM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="EryCIII-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050426">
        <property type="entry name" value="Glycosyltransferase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050:SF25">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="EryCIII-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="19" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="15" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="18" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="10 26" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PH" evidence="25">
        <location>
            <begin position="312"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="495"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="628"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1395"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1465"/>
            <end position="1519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="88"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="116"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="509"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="526"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="537"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="561"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="650"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="675"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="687"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="1398"/>
            <end position="1411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="1480"/>
            <end position="1519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00029843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00059773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="EMF12615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1519" mass="167694" checksum="34A161C0C9A0D17C" modified="2013-05-01" version="1">MASSGKQHDIAASQPALLPIRSGARATSSIKNISSRVRSSLPRRRLSMDLPERLRFDEAEEEDVDDGTGVKDGFPARSMYGMLAAAQSRPNFKKQFTQQESASDSEGEDDKHKRRSVDQRRPSKEISRDADKGRKPSEEGRTSPRPEESSKRHKARLSVNRLARSVLSKHELKPTTKQTESQEQDAMTSSQILPPRVQETTSEARATFVRPDATVLDRKLKAMAQAELDASTSTLTSRKSREEGKAFGEVESDKTNHSLAHVIADIFQFAEPEEVTSEFQCWYLQNVLLQGFMYITTKHVCFYAYLQKKTTKTVKSGHLGKLGKHSYRYRRYWFVLRGDSFSYYNSSAEPYFPNNVVDLRYAISAELAAVPGKEETASDFTITTPSRVYQYRADMVSSAKDWVKQLQKVIFRTHNDGDSVKISLPIDSIMDVERTGVVDFAETIKLRVVDNEETFAIDEYFFTFFHHGEDAVKALIALAAGNGAKKLRIEGAISPLSKHRSPAGRKMSSAEQSPRLSTIKSTLLPASAAERSVSRSSGERRRLERRASSDHGVDVSDRGRTSASAQGRDSRNASKSPMSPSIHASSESFVTSSEPPDSSVDGDAMDADMSASQMLSDDHVFRGPTLRTSQARRTAAGQPAGRPRQVSRASSRDSSGERDSIARVQAPSWPATYRSMGNQRPTPQRTESGDSARTAEPDDRPRPEPSGPKLIRGISTPLQHAMNVAGAVRAGSKRVGSYLSSSPKTYITNWTEAMAGGKRHYTDIEGLAHDEGVREPERHLDYAEHERRFQEHFGLPPTEKLVSVFYCWLHKTVPLWGKIYMGTRRLCFRSLYYGTSTKLIIPYKDILNVQKQRGFRWGYPGMVLVIRGYEELFFDFQDTGLRDDCVVSTLRTVEVVEAAAESMILTEVEQQDASEAAAENALLRAARQTGHDDEEGISLPEEVDALPVIFDDPSASVLEFRPKKSLNITCLTIGSRGDVQPYIALCKGLLAEGHKPTIATHAEFRGWVEKHGIAFKEVDGDPAELMRICVENGMFTPSFFLEANSKFRSWLDELLVSSWAACQGADLIIESPSAMSGIHIAEALEVPYFRAFTMPWTRTRAYPHAFAVPSQKRGGGYNYMTYIFFDNMFFAAIAGQINRWRGKTLKLGPTSLDRLQQNKVPFLYNFSPSVVPQPLDFSDWIKVTGYWFLDEGEDYVPPAELAAFIKKARDDEQKLVYIGFGSVTVSDSRQLMQQIVDAVVKADVRCILSKGWSDRFETAVAASQPALVLPSCMYEIRAAPHDWLFKQVDAVVHHGGAGTTGASLRCGVPTIIKPFFGDQFFFATRVEDLGVGQHLKKVTGNQLGRALWYATHDERMRSKARLLGEAIRSEKGVDTAIKAIYRDMEYAKSLIKKKKQQQAHGATTSTSSDGANASIDLSEDTEENWTFVEMEGEAAAAAAAAAAAAAETEAFGALAAELGGGGAESCLPRSSSKALHGQRSHSSSFRSSSSSSSSSSSAAAIASGQHSRAGGVAVRGGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M3D3K1</accession>
    <name>M3D3K1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NTF2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_117066</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760600.1">
        <property type="nucleotide sequence ID" value="XM_016901306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D3K1"/>
    <dbReference type="STRING" id="692275.M3D3K1"/>
    <dbReference type="GeneID" id="27898443"/>
    <dbReference type="eggNOG" id="ENOG502R8VZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096573_0_0_1"/>
    <dbReference type="OMA" id="EFNAAAW"/>
    <dbReference type="OrthoDB" id="5596743at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058645">
        <property type="entry name" value="NTF2-like_dom_7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26534">
        <property type="entry name" value="NTF2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032747" description="NTF2-like domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="NTF2-like" evidence="3">
        <location>
            <begin position="66"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF12479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="218" mass="23669" checksum="1B4630F1B74DA212" modified="2013-05-01" version="1">MYFATIAVLSTALASSTLAAPGAPEHPIWKKPGGDSWFRRKQVSPPSYEPSTPDSGTECPTPTNSTCLTDEQAAAGAEIFRRLIQDYSDELALDALTEDFVDYSSAVNIIRNRGNEGPFVVNEISFNGRAAFMAAQGSQPEIPFDTLNTFHGCNHVATRWQTLRSANGQATESNDIPVVGNGILVTVPDSNNTYGFRVKELYSEFNAAAWLVNNEEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M3D5T7</accession>
    <name>M3D5T7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GST C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_148605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761365.1">
        <property type="nucleotide sequence ID" value="XM_016905026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D5T7"/>
    <dbReference type="STRING" id="692275.M3D5T7"/>
    <dbReference type="GeneID" id="27902163"/>
    <dbReference type="eggNOG" id="KOG2903">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037263_0_1_1"/>
    <dbReference type="OMA" id="LYWNVKG"/>
    <dbReference type="OrthoDB" id="2309723at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03190">
        <property type="entry name" value="GST_C_Omega_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047047">
        <property type="entry name" value="GST_Omega-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016639">
        <property type="entry name" value="GST_Omega/GSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419:SF23">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419">
        <property type="entry name" value="GLUTATHIONYL-HYDROQUINONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="170"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF13244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="380" mass="43429" checksum="21DD52D1C76412DD" modified="2013-05-01" version="1">MADTTTTDLPASWHTGPEDSFHGKITPEGPFQPEKDRYHLYIGLFCPFAHRANLVIHLKQLHKYAGIETSIVRPYPKGDGKGWPGWRFNVQGAEDNYEGATDDQLFGSKYLHELYFKADENYKGRYSVPVLWDKKLNTIVNNESHELLRDLQTAFNSLLPNDLANINLYPEHLRSQIDALSPILQRDLNAGVYKAGFAPDQATYDKNVPPVFALLNLLERLAASNGGPYLLGNHLTEVDIRVYCTLIRFDIVYVQHFKCNLSMLRYGYPVLYNWLRGLYWNEKVHPAFRETTEFRHIKENYTKSHGEINLRAITPVGPWPHIGAGYEEDWSSVRVGDVDMPEVKECERTLEEELKRSEAEKNGGGNNNNGHGGFSLDNFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M3D657</accession>
    <name>M3D657_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_43235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761475.1">
        <property type="nucleotide sequence ID" value="XM_016908888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D657"/>
    <dbReference type="STRING" id="692275.M3D657"/>
    <dbReference type="GeneID" id="27906025"/>
    <dbReference type="eggNOG" id="ENOG502RV5E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2764712_0_0_1"/>
    <dbReference type="OMA" id="RVVMFND"/>
    <dbReference type="OrthoDB" id="1922977at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF13354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="72" mass="8229" checksum="3452EFFE5DBCA117" modified="2013-05-01" version="1" fragment="single">TDNDLLRLMGTQRTPARGPEQDKRWKQGLNDLIKELRTSGTIGKDAGLIAQRIAEYRRAFVNDPTRVVMFND</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M3D666</accession>
    <name>M3D666_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_148893</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761791.1">
        <property type="nucleotide sequence ID" value="XM_016905210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D666"/>
    <dbReference type="STRING" id="692275.M3D666"/>
    <dbReference type="GeneID" id="27902347"/>
    <dbReference type="eggNOG" id="KOG1430">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045030_1_0_1"/>
    <dbReference type="OMA" id="PQTAWLN"/>
    <dbReference type="OrthoDB" id="16464at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050177">
        <property type="entry name" value="Lipid_A_modif_metabolic_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245">
        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245:SF11">
        <property type="entry name" value="LD23561P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="2">
        <location>
            <begin position="89"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF13670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="467" mass="51202" checksum="E53AEB7B19E38523" modified="2013-05-01" version="1">MADVNGAKVNGDMEGPAAAQTLGTNNDGEQPLSNGEQPVAQSDSQPANTQPTEAQGVSGTSTEQRGAGAVPAIDQRAAASTEPDSRPAVLIIGGLGYVGRYLATYIHSNKLASTLRLVDKQLPQLASLAPEHQAACSEANFLQSDASRVQSQDRIFNLPAGPDGAKREFDYVFNCGGETRFSQEDEVYKLRSYQLSLTVGKEAARRGVKAFVECSTGTVYNSSKTPLKETDKTSKPHTKQAKWKLQAEEELAKIPGLKLIVLRFPNIYGPYGGRGWLGTQLALARVYQSREKETMKWLWNSELRTNTLHVEDASRACWLAADWRSRNDSIPGTQGDSRGTMVFNVVDRGQTKQGTMAQIIKDIFGIDTGFQNALVNTFARLNLEHVVDDVNDDTLDDWADLQEASGIADKGGPLSPFMEKEILRDADLSIDGSRFETVVGFRPQHERITTEEVEAVIESYKKMGWWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M3D6J0</accession>
    <name>M3D6J0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">DNA replication complex GINS protein PSF3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_84345</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The GINS complex plays an essential role in the initiation of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the GINS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GINS3/PSF3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761605.1">
        <property type="nucleotide sequence ID" value="XM_016910349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D6J0"/>
    <dbReference type="STRING" id="692275.M3D6J0"/>
    <dbReference type="GeneID" id="27907486"/>
    <dbReference type="eggNOG" id="KOG1106">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081646_0_1_1"/>
    <dbReference type="OMA" id="YMATIKY"/>
    <dbReference type="OrthoDB" id="10251744at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11713">
        <property type="entry name" value="GINS_A_psf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010492">
        <property type="entry name" value="GINS_Psf3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038437">
        <property type="entry name" value="GINS_Psf3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055221">
        <property type="entry name" value="PSF3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22768">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22768:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22466">
        <property type="entry name" value="PSF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160059">
        <property type="entry name" value="PriA/YqbF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication complex GINS protein PSF3 N-terminal" evidence="8">
        <location>
            <begin position="5"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="GINS subunit" evidence="7">
        <location>
            <begin position="80"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF13484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="184" mass="20105" checksum="43CA8194FB75CCA2" modified="2013-05-01" version="1">MTGYYSPASILTESQKVRTTFELALDSQLSATLNNGNAIEPGTQIHLPIWLGQFLHVSEPGGVGTGSIASVDMPNALGKRVINAMSADPKSVDVRAQAQYFYGLAEKMLETQVNDELSDCLIDSFKQRSLEIADKAQNLRQTQKTGGSDEFLRGCDDTEVMVYKSAHEATKAVKAFFDAESHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M3D6V7</accession>
    <name>M3D6V7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIP41-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_64709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TIP41 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761730.1">
        <property type="nucleotide sequence ID" value="XM_016909689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D6V7"/>
    <dbReference type="STRING" id="692275.M3D6V7"/>
    <dbReference type="GeneID" id="27906826"/>
    <dbReference type="eggNOG" id="KOG3224">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039187_0_1_1"/>
    <dbReference type="OMA" id="DMILFED"/>
    <dbReference type="OrthoDB" id="10253878at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051330">
        <property type="entry name" value="Phosphatase_reg/MetRdx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007303">
        <property type="entry name" value="TIP41-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021">
        <property type="entry name" value="GAF/PUTATIVE CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021:SF16">
        <property type="entry name" value="TIP41-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04176">
        <property type="entry name" value="TIP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF13609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="277" mass="31735" checksum="EFE3C2E3040C6EF9" modified="2013-05-01" version="1">MAPNYGTFSSTSPNGVWTLSTRKQPILKAGPIEQLHQDIGIPIPEMIFGDNFVSLTHNPSHFTLSFNARDAMDRVSKTEEGMLQVAVADEWKETRKNQADEVKEVVKPFDWSYSTDYKGTSSYGHPHQGKGQVEDAAVIAWKESDQQTDPIRTDLLSRQDPIQFFDTVDLYEDELADNGIALLNIKVRMMPERLLILSRYFLRLDGVIVRIRDTRVYVEHSTKKIIRQYTSKEEKYEVVAEKLKGMRENVPEAFRDVNKLAPILPIIEDLTDVFEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M3D8E0</accession>
    <name>M3D8E0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_115437</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762270.1">
        <property type="nucleotide sequence ID" value="XM_016901162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D8E0"/>
    <dbReference type="STRING" id="692275.M3D8E0"/>
    <dbReference type="GeneID" id="27898299"/>
    <dbReference type="eggNOG" id="ENOG502RQU2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_903643_0_0_1"/>
    <dbReference type="OrthoDB" id="3632925at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF14149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="308" mass="34970" checksum="03DDC93ED46ECEF5" modified="2013-05-01" version="1">MAMKQITNRWRRTNATAIYEPVNPPTADVLRKIGTMEPSDKGFTVEPSTLYLTNSERAEIRAFARRIKHIEANSEERKLARVFRILDLPVDVRLIIYEHTFQEKLDDEHVLAVTATPKVARVCKTFRAEALPLFFANTEFHLPIGSNLLHRALYRKHALGGRFNALRTSGQQKRAGVLNFKKPVKKAIRDAGDDAVFRNVVLQMFEVAESSFHRAGSSKFSCFIEIKLSLCKGQLRVDATEKYAHPSNKIVPREYRWAGGYPIEREDVDVVVAEVRRVAARIASTAGFKGLKLCDLESLARAFRFTQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M3D8V0</accession>
    <name>M3D8V0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose 1-dehydrogenase (NADP(+), D-xylono-1,5-lactone-forming)</fullName>
            <ecNumber evidence="3">1.1.1.179</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">D-xylose-NADP dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_132196</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-xylose + NADP(+) = D-xylono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22000"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15867"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.179"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.179" evidence="3"/>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762686.1">
        <property type="nucleotide sequence ID" value="XM_016902480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D8V0"/>
    <dbReference type="STRING" id="692275.M3D8V0"/>
    <dbReference type="GeneID" id="27899617"/>
    <dbReference type="eggNOG" id="KOG2741">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_7_6_1"/>
    <dbReference type="OMA" id="TCRWAAL"/>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047837">
        <property type="term" value="F:D-xylose 1-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050984">
        <property type="entry name" value="Gfo/Idh/MocA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604">
        <property type="entry name" value="OXIDOREDUCTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604:SF105">
        <property type="entry name" value="TRANS-1,2-DIHYDROBENZENE-1,2-DIOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="42"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="7">
        <location>
            <begin position="160"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF14565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="396" mass="44304" checksum="4AF2D4469BE03F10" modified="2013-05-01" version="1">MDSKSFTCRWAALSLSSIAGVFFPDILLPREPATDSSTIKHELVALSTTGSRERAQTWLQEKEIPSSQKVQIYHDWKEMLSAGDFDVVYISTPHPLHYEHVRYALSKKRHVLVEKPAMMNAKQFEKCAELAREYGVVLMEAMWTRYLPATRYLQDQLLPRIGQVKRVFADFSFPIVSEDLSHSSRFLDKMAGAGSLLDQGVYALTWADLSLNGGTTTTTARTSRVDYANTMSVPGVAGEVDDITTVMLTKRDSTTDAQEAVAIVTTSMTLPGSSKPAFYQRLQAKKAAPSIRIEATKASVAIPFPPIRPQQLQVQWYDSEHLDGQGIEQEEVIDKPVERGWGMWYQADVIAQTIMSRERGAAGEVIGLQETLRVLGWMDDARRHAGIVYDAELDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>M3DBH3</accession>
    <name>M3DBH3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_154087</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763330.1">
        <property type="nucleotide sequence ID" value="XM_016907546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DBH3"/>
    <dbReference type="GeneID" id="27904683"/>
    <dbReference type="HOGENOM" id="CLU_821755_0_0_1"/>
    <dbReference type="OrthoDB" id="3807907at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF15209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="338" mass="40203" checksum="DA745DFFA73DC37B" modified="2013-05-01" version="1">MSTIQSIQESSTSNNILENNYDLDYYYEYTTFFIRKYINRSSTVKSTRIDKTLKAIINYTRQSLNNGNTTGGYFLLDYLNKVRIIYFIKRLKYYNFSGYKEIINIIYKPADRRIKIDLDLRKFLNSYKDDIYATMLLNRINGYLIRYSLYFKDLNLAKSFTTNKIITYSNYFTYKDSISKDQSYYYYTDILDDLTFLGTLNYYTEIKPEHKDTILYFIETTPKEDIKSITPDKLKEILLNPLTILSPTDDSNTLNLDLNILDTDYFEDYNTCNNKEDLLGYKDSSRDSREYWTEREGIDTRMLDISEIEEKDRLNSRTTSQEYKEENRAINALDLAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M3DCD0</accession>
    <name>M3DCD0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutamyl-tRNA amidotransferase subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_60333</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763590.1">
        <property type="nucleotide sequence ID" value="XM_016909521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DCD0"/>
    <dbReference type="STRING" id="692275.M3DCD0"/>
    <dbReference type="GeneID" id="27906658"/>
    <dbReference type="eggNOG" id="KOG1211">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025343_0_0_1"/>
    <dbReference type="OMA" id="VTTECCF"/>
    <dbReference type="OrthoDB" id="167809at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00431">
        <property type="entry name" value="cysteine_hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006043">
        <property type="entry name" value="PRK08186.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF169">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="2">
        <location>
            <begin position="22"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="3">
        <location>
            <begin position="273"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF15469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="708" mass="76158" checksum="EDA28C86E833EB90" modified="2013-05-01" version="1">MATVMELPSARPYPYKFPPESTALIIIDMQRDFVDYHGFGQIQCGNDEVFKKVRNIVPRTRQALEAARSLGLHVVHTREGHTPDLSDLPPSKRLRQISAPSGHHTMGIGDAGPMGRLLVRGEYGHDIIDELRPIPGEPVIDKPGKGSMWDTNLHRVLLARGITHLLFAGVTTECCVNTTARECADRGFETCILADCTDGFDEGFYSSTLDMLCSYDGLFGFVGTSAELLKYAPPQAPTPPTTPPGFSGDISIANLRKQYTAGQLRPTDTVKEVHARAASYRLKDSAVWTHLRDVEEILKDAQALEDRFSGKPLPELYGIPFAVKDNIDVANVKTTAACEAYAYLPGRSAKVVETLLEAGAIFIGKTNLDQLATGLSGCRSPYGTPHSVFSTHHISGGSSSGSAVAVGAGLVSFALGTDTAGSGRVPAAYNGIVGHKPTKGTFSASGLVPACKSLDTITVLAPSVNDARKVWLVADIGGDETDPYSKSPSSLALWHADFRGVKVGGFTFGIPPATALEKCDGKYQELFAASVDRLTRAGGTPKEVDWVAFEGGSNLLYEASLVQERIASIGPEFIEKNINTLHSTTNKLFSEAAHKDVKPWQVFRDQHLQAQYTRDAASIFQSIDVLLVPTTPCHPTISEMESDPLALNAKLGYFTHFANVLDLCGVAVPAATYQDATGTTLPFGVTLLGASGRDGRVYDIAREFERTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M3DE47</accession>
    <name>M3DE47_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calmodulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_139667</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF16035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764156.1">
        <property type="nucleotide sequence ID" value="XM_016902912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DE47"/>
    <dbReference type="STRING" id="692275.M3DE47"/>
    <dbReference type="GeneID" id="27900049"/>
    <dbReference type="eggNOG" id="KOG0028">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061288_5_1_1"/>
    <dbReference type="OMA" id="FHDVMTR"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000178">
        <property type="entry name" value="Calmodulin-2 A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF59">
        <property type="entry name" value="EF-HAND SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="83"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF16035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="199" mass="21579" checksum="3A424E280527248E" modified="2013-05-01" version="1">MSAPHLKSPPHPKKVAPAAASASTSKRRSKLAKENDISAEEESEIQEAFALFCSNSNSKDSSPATIRTIDIRRSLIALNAAPGNKDDLQELIDIADPDADGVVDYEHFLPVAALQVNRAKNERDEEQQSAEVEKAFALFTRGEERDITLGDLKRIAAELREDVPESVLRDMVREAKGGGLGGVGKEEFEGVMRRAGVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M3DEW0</accession>
    <name>M3DEW0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_22487</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF16054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764175.1">
        <property type="nucleotide sequence ID" value="XM_016908354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DEW0"/>
    <dbReference type="GeneID" id="27905491"/>
    <dbReference type="eggNOG" id="ENOG502R9VQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2298494_0_0_1"/>
    <dbReference type="OrthoDB" id="3645041at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF16054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="101" mass="11526" checksum="4D35970A4C1FB32C" modified="2013-05-01" version="1" fragment="single">DDGQDDWDEFAGSPEDYKTAGEGRMARCIASVFMQRAKRAYRAGRTWRSFEDEELAIDTQAAARAESDARKRKVLLAEALCGKSRLEVFDQIKERLCTEIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>N1QD73</accession>
    <name>N1QD73_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_151311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757317.1">
        <property type="nucleotide sequence ID" value="XM_016906736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QD73"/>
    <dbReference type="GeneID" id="27903873"/>
    <dbReference type="HOGENOM" id="CLU_1435248_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="189" mass="20640" checksum="F0CDA55C88A6626E" modified="2013-06-26" version="1">MGMLNHPHQPPSVLTRRRPEETHNGSERRALYRAHQPTIMKKRSADTRKLPVYSWTEYPRYTLGSSYPREALEMLADAAASARGMPRSSVPAEWAGGAMLDLHHFTTSADGRLLLPPLPPLMPPPPPPMMPPPPPPLVAVERGGHAPMKVETADLAPPRHHFRAPPCAEFTSDTPPSKTSPAPPSISPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1QD97</accession>
    <name>N1QD97_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="14">PI31_Prot_Reg-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SEPMUDRAFT_151352</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the proteasome inhibitor PI31 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757377.1">
        <property type="nucleotide sequence ID" value="XM_016906758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QD97"/>
    <dbReference type="STRING" id="692275.N1QD97"/>
    <dbReference type="GeneID" id="27903895"/>
    <dbReference type="eggNOG" id="ENOG502RZMJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044125_2_0_1"/>
    <dbReference type="OMA" id="GHACMVA"/>
    <dbReference type="OrthoDB" id="68090at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045128">
        <property type="entry name" value="PI31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013886">
        <property type="entry name" value="PI31_Prot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021625">
        <property type="entry name" value="PI31_Prot_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13266">
        <property type="entry name" value="PROTEASOME INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13266:SF1">
        <property type="entry name" value="PROTEASOME INHIBITOR PI31 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08577">
        <property type="entry name" value="PI31_Prot_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11566">
        <property type="entry name" value="PI31_Prot_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PI31 proteasome regulator N-terminal" evidence="13">
        <location>
            <begin position="28"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="PI31 proteasome regulator C-terminal" evidence="12">
        <location>
            <begin position="276"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="184"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="309"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="342"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF11566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMF09256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="374" mass="39771" checksum="9A31259E0886C446" modified="2013-06-26" version="1">MSDIPPINALSGSTISKYMLASFPANASPQLRNAYDAIALAAHASMLAVGFRLVGLGEEHRVEASSDHDSPQPLPTEWNASSGSYAFRYKHGQSSMEFLVKVSRMGNKAIIMAMGVPDDRTHTTEVKADEYVSAGNLPLELAEDQEKDQKSDAIISTFINVGRLSDFGSLMRVKLIQKLVPSMQKEGYEETREEEDQAATGSRQQPAPGREGNQPQYDPLREQRDPPARPYPLQDPLVQPRRGPLPDPMPGFDDEYEVNGPPRGMGPPGGGLGRFGDRDLYPQGLGPYDPMRGGVGPGLGGGFGGGGMHPTFDDPLFAGQGQQGGRRGQAPPGARYDDPFGPGSGGQGGGHPRGAGMGGRPPNPFGGFGDGDFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>N1QEB2</accession>
    <name>N1QEB2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_150716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758811.1">
        <property type="nucleotide sequence ID" value="XM_016906351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QEB2"/>
    <dbReference type="GeneID" id="27903488"/>
    <dbReference type="HOGENOM" id="CLU_1338252_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF10690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="205" mass="23058" checksum="3CCD5C6228D5FEC6" modified="2013-06-26" version="1">MLVTQGATQDPPFVCTPLEMAPSTKKRFQREQIQTKRYRDMVIAYATILELLQKSPLPASLLARVLGITPHQARYRMSLIQEDVTSLKQAFVDGKCQVGRPTRKSPTKKSPRVKGETVPSKFQAAPHATCPFDNAPHVSMTPSKDDDPFTPYWSPTFVWTPGLPWPYEIYQTPMYNTGDVSRPQTPAADSKFINPQVLTITNSTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1QER4</accession>
    <name>N1QER4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_66729</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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    </feature>
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        <location>
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            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="305"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF11623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="572" mass="61395" checksum="FBF0DDCF5109C6D6" modified="2013-06-26" version="1">MANALESLDAAIANLLADWSILTTLLALVIAAFLAYPIVFPDEPDTHPLLLARQATASAVRNKGESAVYRSPEVPHGYPLKTGLNVKDAGAPRWAAGRDGDVRDIWREVQRGGSAGPDGGKEVPKGLVMTVLGQEEVVEHDIDQLSRDMAIMGKHFKDAGVKKVAIYLPNSVEYLQTIFAAAFFGITPVLLPYNLPHAKVYELLTATGADALVSAAGTVPLQDLTKSCTQLRLVTWVVEKTSKHMDWNGVPDHAQDHLQISVWHNVISEHQSSASPDLPSNEAGEKLADFIFVWQPTDPNLKPDIVTLSQSNIVAATAALISAVPLRQRLTSADLVLPADSFGHSYVLCQTFAALYTHASLAISSVAAPGVDLTLVQKAIAPTVIIASAESLAKLHHQHLGTVSSGLQKFGKYTQDQTIAAGRLPTDGLLFKFLAPPSNGSAQPGKLRLIFTSDRWSAGSPPLTSTMLSDLRIFTRSRICYALTVPHVAGAVAQTNVFDYRRVDGSSHGHFGVPLSCVEVKLLNRENDQMVSGNEPMGKLKVIGPAVASGKKCQVDLEVKAKIREDGTLVYA</sequence>
</entry>
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    <accession>N1QF58</accession>
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        <submittedName>
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        </submittedName>
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        </lineage>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="1"/>
            <end position="23"/>
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    </feature>
    <feature type="chain" id="PRO_5004110727" evidence="2">
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            <begin position="24"/>
            <end position="107"/>
        </location>
    </feature>
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        <location>
            <begin position="38"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF11807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="107" mass="10880" checksum="13E03F330D54EB0E" modified="2013-06-26" version="1">MKASLSTLLFLATAAGLAQAAAATENLAARDNTLSLRDALPEAAAEEISTTAQNDKRDGPDGEEKKEDGFDEEEKRRGGGYHNAAGRGAVPVVGGVVGVAAVMAALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFC9</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_120039</name>
    </gene>
    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="123" mass="13234" checksum="779C9DE92DD139E1" modified="2013-06-26" version="1">MTMGSTLGAREQTKISFCQRGNFIRPRWRNIMLGSTSVTLLGLLPPFQHIFQFNVLRVAAVRSLSHGLSVLKAVSRGQSALPVCSSTQSVAETGRAGEGDQYKDSKAEKKQQKKGESGHGGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFG8</accession>
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    <protein>
        <submittedName>
            <fullName evidence="1">Cytochrome P450</fullName>
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        <name evidence="1" type="ORF">SEPMUDRAFT_46230</name>
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    <organism evidence="1 2">
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        <lineage>
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            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016908989.1"/>
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    <dbReference type="GO" id="GO:0020037">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cyt_P450"/>
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        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF168">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P450"/>
    </dbReference>
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        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF11952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="465" mass="52075" checksum="AD0F87A89180B2C8" modified="2013-06-26" version="1">MALLSSFAVALLTVLVLYYCVGAILGYRRLRQFPGPPLASLSRFWLFWKECRGSLPSAQVAALAKYGSPARIGHDLLVTDDADLIRHMYGTTSRWTRSGWYDAMRMDPRQDNVFSTRNEKAHTDLRAKEAGGYNGRDINTLEPDIDARISDLVELIRKYEGQSVDFAPKVRYFVLDTLSTVAFGRPFGFMAADKDKWDYCQTSDDFTLFLGLTANHSSIRWLLSQPWIQALAAPKTTDQTGIGPALAFAHAAVSERYGPDAKVRKDMLGHFVSKGLSQVQCECEAFLQIMAGTDSTATVLRCAIFSLAGNPRVYTRLRAEIDGAIRGTTSEIKYTDTLKLEYLKAVIWEVIRLFPPLFGLKEKRAPPGGDEFNGVFYPEGTGVAICDEAVMRKKEIFGEDVHMFRPERLLEGDQALRRHRMQTIEVAFGHGRYLCLGKHIAMIELHKAVVAVRLVHSPPPDADRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>N1QG40</accession>
    <name>N1QG40_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Splicing factor U2AF subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">U2 snRNP auxiliary factor large subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_48483</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Necessary for the splicing of pre-mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the splicing factor SR family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758868.1">
        <property type="nucleotide sequence ID" value="XM_016909070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QG40"/>
    <dbReference type="STRING" id="692275.N1QG40"/>
    <dbReference type="GeneID" id="27906207"/>
    <dbReference type="eggNOG" id="KOG0120">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021795_2_0_1"/>
    <dbReference type="OMA" id="MTQWDIK"/>
    <dbReference type="OrthoDB" id="10266058at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000243">
        <property type="term" value="C:commitment complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089701">
        <property type="term" value="C:U2AF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd12231">
        <property type="entry name" value="RRM2_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12232">
        <property type="entry name" value="RRM3_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000097">
        <property type="entry name" value="U2 snRNP auxiliary factor large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006529">
        <property type="entry name" value="U2AF_lg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01642">
        <property type="entry name" value="U2AF_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23139">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="106"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="226"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="333"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF10747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="432" mass="47242" checksum="742E3DA3E0E7DEEE" modified="2013-06-26" version="1">MRQLERQIKREASGSPPPKKPREPTPDLTDVVSVLERKRRLTQWDIKPPGYDNVTAEQAKLSGMFPLPGAPRQQPMDPAKLQAFMNQPGNQASSSALKPSSARQSKRVMVHNLPPSATDESMVDFFNLQLNGLNITRGVDPCISAQCSKDKTYALVEFKTPEDATNAMALDGITMDHDAMDTSGASNGAPKGLQIKRPRDYIVPNVIDETENESGLLSNTVPDTQNKISITNLPSFLAEEQIQELLMSFGELKSFVLVRNQSSGESRGIAFCEYKDPSVTKVAVDSLNGMELADTAMRVKLASIGIQQVSSEMSVNAMSLMAGAKSTDADNGRVLALMNMITPEELMDPDDADEILEDVKEECAKYGPLLEVKMPRPTGGSRQSTGVGKIYLKYETSEHAAKALAALAGRKFADRTVVVTYFGEEYFDVNAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGM7</accession>
    <name>N1QGM7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_128307</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757839.1">
        <property type="nucleotide sequence ID" value="XM_016902208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGM7"/>
    <dbReference type="STRING" id="692275.N1QGM7"/>
    <dbReference type="GeneID" id="27899345"/>
    <dbReference type="eggNOG" id="KOG0385">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_32_0_1"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="40"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="520"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF09718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="547" mass="61954" checksum="90677D2324EBE2F9" modified="2013-06-26" version="1" fragment="single">MNLLMQLRKACAHPYLLSGAAPLEYEIGDHVKNASSKFIVVDKLIEELCIKRGKKVLIFSGFTRMLNLCEELLHNKGANTRQGSFRFARLDGSTSRAQRNLSIRLFNQMDSDYKVMLISTRAGGLGINLTSATDVVFLDEDWNPQVTLQAEARAHRIGQTQKVTIYKLCTSGTVEEQMMGRIRKKLYLSAKITESMQNIHTGNSPEKKRKRQISGRATAVDDDAPHLDTASLQSLLRRGAQTLARPEVPVDELLSWDWETTLENCKDKPLDPLVVGANGEVAEVDEQKWLNTMERVECAIFEGKKHDKELEKKIEKTVDLNRADRRAGKNTTVEIDGFMINKISLNCADWEAVPTLAGKDPRLAEFKKEKKPPIQHQEFCQCCWMGGEVHTCSSCPRAYHQLCLDRDWRAKMRSTLQFHCPQHQCRDCGGKTTDVGGMIYRCRWCENGFCEDCLDWDTVTLVGDTLPEFEMRNFGKNAQAYFVECPHCIQRMQADPNDAKLTANERAKIESRYAAWLLEEGEEESGPSPTFAQDTPDTVSEVMTPMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGN5</accession>
    <name>N1QGN5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Subtelomeric hrmA-associated cluster protein AFUB-079030/YDR124W-like helical bundle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_133657</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016902573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGN5"/>
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    <dbReference type="eggNOG" id="ENOG502S0ES">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OMA" id="MAEDKMP"/>
    <dbReference type="OrthoDB" id="5338458at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047092">
        <property type="entry name" value="AFUB_07903/YDR124W-like_hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021264">
        <property type="entry name" value="AFUB_079030/YDR124W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36102">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36102:SF1">
        <property type="entry name" value="YDR124W-LIKE HELICAL BUNDLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11001">
        <property type="entry name" value="AFUB_07903_YDR124W_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Subtelomeric hrmA-associated cluster protein AFUB-079030/YDR124W-like helical bundle" evidence="2">
        <location>
            <begin position="184"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="630"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="440"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="630"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF11639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="677" mass="75648" checksum="C0CB46DEDF6F1BED" modified="2013-06-26" version="1">MAVTHSVSKRQKATKKAETETLKNAPSAPNFDSIRRSLGSRQAWAVVDLDERGQVIPGSEQVKGSLDGPIFGTPVQQALVQSQERYMPQAAVSTETQPDEPTYHARSVNVPTTRSAKTRGRSHIAPAEHGRQRGRAVLPRPALPLSTCPSPSPETAIPDFAAAAASVGPEVVLPPHKQLKSLRINNPAAVQWFLSSRLKRMQQLADKKIAKAWIKGICPKKQAKFPYQNNKHEKETGEKPAVPAWWPDTETVCRFVEPDHIRREERMGLCLHLLRLRPSPSQLEEWNRYDTPPSKTHIERGWTAWLEELAGPEVFDEVPKDASHRLKYRRQLMKDMYEVARMEEEYLGGALDGDSHFQYESEEEERKPISTKRSRQISAASTPDCENPTPRSTSPSCTRPVTKRARRDSTATNATVTESRVPDRKPGLDMIPLVTDPGRSAATSFSDSFDSTPRNSISCGPLESGNVVASHPDQPSPLHHMHGLPRHNVFQGASSHGYSQAHQWHEHSMSGFNEQQQTGGSDFQYQGQVAPNTFPGRQDFEFPQFPQQFVPIHQVHMGFAPQPEFQSTPSTPVFSPTGMVSMPMDTFSLQQQSGVIPGGQYMQPSQYFLPAHHGLDSAVADFHPPVNMVGPQYQQPQQQEPGGLGQQQHMAPLSQQNHAMLMPHQPMQWHHHHHTRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1QH85</accession>
    <name>N1QH85_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HCP-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_145808</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EMF16586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016903281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QH85"/>
    <dbReference type="STRING" id="692275.N1QH85"/>
    <dbReference type="GeneID" id="27900418"/>
    <dbReference type="eggNOG" id="KOG1550">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_126_0_1"/>
    <dbReference type="OMA" id="CCEMGPE"/>
    <dbReference type="OrthoDB" id="272077at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051726">
        <property type="entry name" value="Chitin_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430:SF3">
        <property type="entry name" value="ACTIVATOR OF C KINASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430">
        <property type="entry name" value="PROTEIN SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="451"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1159"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="188"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
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        <location>
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            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="280"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="358"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="404"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="567"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="628"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="674"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="763"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="773"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1159"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1178"/>
            <end position="1192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF16586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1192" mass="131080" checksum="565C0F242454429D" modified="2013-06-26" version="1">MAYDQNSAYEPPRRPYQARPQPPPAPVSHGYNQYSDYASTPFDQRQAQYDQTSYPQEPLQNGGYNQHYQRGIDQGYGSGYEQARSRPPPPPQQQQHENQYRQEHYGEQQDYGNGDRSYDARYQPRAQQQRAPPGQQRGPAPNGRPMHGDPTSQQPQWEQYDQRPAQDQYAPQLPGGYSNGYSNDAPSQQAPNTQKRQQPQQPQQPQPPGRSSMEEWKARERAKMKAEARSPETLPFDNAFPVFGDNKKDERPDSKQSERRNGQGSRDQERRPMALEGQRSYGSGENGYQNPASRPDMERRDVYPEPPQNGRHEMSAPQHSQQGRPAYPQAPPPNQVGSPIDQHFDFGLGQDAPRQANGYHQNHYPQPSSNQQGYAPAEPGQRAMPQSRGPGSVPPIDTSRAQHHQNPVYNNHQPLSPAHVPPRPSTSHGARPQGGHQATVPLAQLQNGTLHDDYASLPSKPFARVENSRPASLGDIYDDYGAEPAPPPKPLQRRPTNREEEIEADMPDFDNVAPARTSHLGKLLPANGPSTSPLPPAVTPAGHPGLPQSSSMPDVRYEQSAQPYPPSDRRLPPAERGPPRHDGYHGGASSVPPQGYAQRPPPGAQDPRLRQGPANNMQPPRAPFAHEPQVRRSLDDGRPLPYRNGPPPPQRFDAQGRPLAPRGPPHGMRGGPNGMHPRGGPNGMPMGRGFPGRPDLDRQGTTWSDPGRTGSAPPSQGPPPNGMGAPLSQQRSAPDRNPPPHNPDALPFHPVPVRPGLLDRGGDPPPSQPPPNRNYNGSHSSPPGQVANGDASHQRQVSTDPFAQPVTHAELERLRAAVDNAPSNMNLALVLVKKLVEASNVLATEGGRADPRTTSKNREKFVMEAHKRLKRLVGGGFPEAQFYLADCYGSGALGLEIDPKEAFKLYQAAAKENHAESAYRTAVCCEMGAEEGGGTSRDYAKAVQWYRRAATLGDGPGMYKLGAILLKGLLGQQRNVVEAVIWLKRGAEKADADNPHALHELAQIYESENTNPEIRSKVVADDSYARQLFEKAAGLGYKHSQFRLGQAWEYGSLGCGIDNRTSIAYYTKAAAQGEHGAELALSGWYLTGAPGILENSDTEAYLWARKAASSEPPLPKAMFAMGYFTENGIGCPQSMEEARKWYSRSASYKFPKAIERLEELKRNGGKKEKAMPQNGKLSRKDQKKDEENCVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1QHC4</accession>
    <name>N1QHC4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutamate-1-semialdehyde 2,1-aminomutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_72125</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
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        <property type="protein sequence ID" value="EMF09429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757550.1">
        <property type="nucleotide sequence ID" value="XM_016909972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QHC4"/>
    <dbReference type="STRING" id="692275.N1QHC4"/>
    <dbReference type="GeneID" id="27907109"/>
    <dbReference type="eggNOG" id="KOG1401">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_1_2_1"/>
    <dbReference type="OMA" id="NFGMVEP"/>
    <dbReference type="OrthoDB" id="425114at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43713">
        <property type="entry name" value="GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43713:SF3">
        <property type="entry name" value="GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE 1, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF09429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="453" mass="49238" checksum="D93CD3277D656E49" modified="2013-06-26" version="1">MATTTTCTSTTACATTEQACHELETEYIARNPTSKKLYSRATEVLPGGNTRTVLYYDPFPIYITKASGCTLHDADGHEYIDLLGEYTAGLYGHSEPVIIHAINAAAQRGLSFGSHHEDEISLANLVQQRFPSMELLRFTNSGTEASLMALAAAKMYTKKSKILVFEGAYHGGVLSFSANGISSPVNAPHEFLIAKYNDLASVQQLLVDDDDNNNKANLAAILVEPMLGSGGAIPARTDFLIGLRSLANATGAVLIYDEVMTSRMHNGGGIQSLQESFRPDMTTLGKYFGGGMSFGAFGGRREIMKIFDPRIPGAVSHAGTFNNNVLTMAAGRAGLEHVFTPQRALLLHSMGEELRGKLNLLGEGTLLQVTGVGSIMCFHFTRMAAGEIMSSRDVEDADGRWNKILHLFLLRKGYYIARRGFVALSLAVKDSDLEGFVDVVRDFVDTYRNLLQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1QHG0</accession>
    <name>N1QHG0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_152807</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SH3BGR family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764751.1">
        <property type="nucleotide sequence ID" value="XM_016907485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QHG0"/>
    <dbReference type="STRING" id="692275.N1QHG0"/>
    <dbReference type="GeneID" id="27904622"/>
    <dbReference type="eggNOG" id="KOG1181">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033575_4_0_1"/>
    <dbReference type="OrthoDB" id="9932926at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006993">
        <property type="entry name" value="Glut_rich_SH3-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051033">
        <property type="entry name" value="SH3BGR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12232">
        <property type="entry name" value="SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12232:SF0">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04908">
        <property type="entry name" value="SH3BGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="159"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="259"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF16630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="310" mass="32310" checksum="5A251FD7FAA315D9" modified="2013-06-26" version="1">MTSTMDLTALEKDPRLFLYTSLTAGSSHIVTATSRMETILKANKIPFQAIDLATDEQARRLWQRRAGKRKLPGLVKEGFVVGDLNEVEEWNEFGELRENIGPVPAGNVAVPKGGPVGVQTAPALSHNITPAAAGTSTTAKSAAPAPVSRSQGIALPGAAEIAARSKKSSPPASASAVSGGDKSTPMALGKSADGKVTKTPTPELSSSKVNSQKGNEPSHKEEQGEDDVPEASAAVEGLKISEPSIDDTTGSSEAVAKTVEADETTKGKSSDIVDVPARSAETEEAQSQPAKATERAEADKEKEEEEEKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>N1QHI8</accession>
    <name>N1QHI8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_110956</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757600.1">
        <property type="nucleotide sequence ID" value="XM_016900886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QHI8"/>
    <dbReference type="GeneID" id="27898023"/>
    <dbReference type="HOGENOM" id="CLU_1887061_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109579" evidence="2">
        <location>
            <begin position="19"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF09479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="158" mass="17090" checksum="775B5FE7259E9CA0" modified="2013-06-26" version="1">MLLSYALFVASAAATALSSSQLEARKVKDSDSTETGNSTKTGNPATDQPSDENIPKDEPFCLCIDLSLPPEDAVDETLTEDVCGIQGGQYATYKANSLGDRLLGGCFSYDFFWTQEVVDSWTDDCLAQSGNQCKYIAACYDKHGYEIRSDPHNGTDCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1QII2</accession>
    <name>N1QII2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(+) diphosphatase</fullName>
            <ecNumber evidence="4">3.6.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_149957</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60876"/>
            <dbReference type="Rhea" id="RHEA-COMP:15698"/>
            <dbReference type="Rhea" id="RHEA-COMP:15719"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:144029"/>
            <dbReference type="ChEBI" id="CHEBI:144051"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:60877"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family. NudC subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.22" evidence="4"/>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760360.1">
        <property type="nucleotide sequence ID" value="XM_016905874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QII2"/>
    <dbReference type="STRING" id="692275.N1QII2"/>
    <dbReference type="GeneID" id="27903011"/>
    <dbReference type="eggNOG" id="KOG3084">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037162_0_2_1"/>
    <dbReference type="OMA" id="CNTRTTL"/>
    <dbReference type="OrthoDB" id="10249612at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006742">
        <property type="term" value="P:NADP+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03429">
        <property type="entry name" value="NUDIX_NADH_pyrophosphatase_Nudt13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000042">
        <property type="entry name" value="Probable NADH pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050241">
        <property type="entry name" value="NAD-cap_RNA_hydrolase_NudC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015375">
        <property type="entry name" value="NADH_PPase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049734">
        <property type="entry name" value="NudC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015376">
        <property type="entry name" value="Znr_NADH_PPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904:SF6">
        <property type="entry name" value="NAD-CAPPED RNA HYDROLASE NUDT12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904">
        <property type="entry name" value="NUDIX HYDROLASE, NUDC SUBFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09296">
        <property type="entry name" value="NUDIX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09297">
        <property type="entry name" value="Zn_ribbon_NUD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="10">
        <location>
            <begin position="259"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF12239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="422" mass="46440" checksum="CCDCC8D2B5E39958" modified="2013-06-26" version="1">MVPQPDNPEPAHHDIDSMLSRKFGKEVANYFSGSPLNRVGFLRADHQFLSQALKHPSTAFLLCNELQPLVQSGTAPGKGRLQYVKYEDVQPVIGSDPFAQSEKEMLDAYRSDQYIPQMIFLGLDEKVPEGEGLAYQAKNLYKGAPYFAVDVTPRPQADARISEACKTLITRLQKEQGFEFGKGRIMDIEPSDAAIYAEARQLLDWNQRNPFCAACGHKTFSVHAGFKRTCPPTDRAADASAVERPACVTRHGVSNLCFPRTDPTVIMAVINHAGDKILLGRQKRWPPYWYSTLAGFAEPAESIEEAVRREVYEEAGVIVGRVIIHSTQPWPYPANLMIGAIGQAVAGDGEKIDLGNDPELDDAKWFSFDEVRHSLRVGTSGLGEDAGPEYKEGDLRLPPSTAIANQLMTAVANGFASGDSKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>N1QIY4</accession>
    <name>N1QIY4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphatases II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_31128</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764358.1">
        <property type="nucleotide sequence ID" value="XM_016908469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QIY4"/>
    <dbReference type="STRING" id="692275.N1QIY4"/>
    <dbReference type="GeneID" id="27905606"/>
    <dbReference type="eggNOG" id="KOG1089">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001839_5_1_1"/>
    <dbReference type="OMA" id="RTMEGFM"/>
    <dbReference type="OrthoDB" id="271628at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF128">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3,5-BISPHOSPHATE 3-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="5">
        <location>
            <begin position="135"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="14"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="245"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="524"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="527"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="2">
        <location>
            <position position="424"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="360"/>
            <end position="361"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="424"/>
            <end position="430"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF16237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="683" mass="76423" checksum="1ACFCAEA70F815DD" modified="2013-06-26" version="1" fragment="single">GTLTLRKHHLVFTYVPTPPDQHGSGLSTPRASRESSDAGAPAKTPGAKRKLKDMWLPYPLINHCVLRPGHQHTRIRIRTRDFRLMAFTFYGDAVKSSDAAAREVFYCLRNRCCVDRVQDLHAFYFKAPQEETSISGTAYDARREFARMGIGAKAAEGVGSAWRISTINEDYTFSPTYPSILCVPATVSDNMLKYGGPYRSKSRIPALTYLHSNGGSITRSSQPMPGLAGKRNPQDERLVSAIFSSQTPSEDASTPVSLQDTSHQPTLKESDERSARDHERGDGRILADTDLATTSSDAVENETIPRPKVYGTTRKRLIVDARPRLNALANRATGGGIEDVSNYCDSSGELPQRLFLDIANIHVMRKSLALVVESFGSADYIRAAPLSDLLQKSGWLGHIAGLIDGSEKVARAVGLGGDHVLVHCSDGWDRTSQVAAIAEVMLDPYYRTFTGFMTLIQKDFLSFGHKFNHRHGVLGCEKWFDIEHERVMPMNPRENGVAVSNLGSKALSGAKNWFEKNRNGLFKQQNDSRSSLDGSPSRPPSPPTNPILHSPATSSTVKDREHKVKEDEIAPIFHQFLDAVYQLQYSYPTAFEFNEVYLRRLLYQVYSCQYGEFLFNNEQERSAQGHLLPSVWPHFVARQGEFSNPNYAPKLHDSLLLPKRSAAGRDLEVRWWSQVFWQDDKKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJ49</accession>
    <name>N1QJ49_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Mediator of RNA polymerase II transcription subunit 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Mediator complex subunit 13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SEPMUDRAFT_145599</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the SRB8-11 complex, which itself associates with the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the Mediator complex subunit 13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764438.1">
        <property type="nucleotide sequence ID" value="XM_016903152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJ49"/>
    <dbReference type="STRING" id="692275.N1QJ49"/>
    <dbReference type="GeneID" id="27900289"/>
    <dbReference type="eggNOG" id="KOG3600">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002210_1_0_1"/>
    <dbReference type="OMA" id="DRCTLFG"/>
    <dbReference type="OrthoDB" id="103819at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009401">
        <property type="entry name" value="Med13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051139">
        <property type="entry name" value="Mediator_complx_sub13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041285">
        <property type="entry name" value="MID_MedPIWI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48249">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48249:SF3">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06333">
        <property type="entry name" value="Med13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18296">
        <property type="entry name" value="MID_MedPIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0010">Activator</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MID" evidence="14">
        <location>
            <begin position="579"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="domain" description="Mediator complex subunit Med13 C-terminal" evidence="13">
        <location>
            <begin position="773"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="51"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="148"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="291"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="930"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="295"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="934"/>
            <end position="971"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMF16317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1124" mass="120655" checksum="B23163F3AB0B78F6" modified="2013-06-26" version="1">MVISPSFAQRSVDHHSTMAGIYPTPPDGFAPGQPSALNSVVTPLATQPELNSSVAEAYAPNDELQPKAASRPAPSNEPGDHELAQEELFADDGGMAFGDAEIDDAEFDFFDEPDDGFVEHQAAQDSNMPDVSTYEDTEVLEAVSNLAQDEEGNHDPPVGIPPVLMPQQGLNDPTPMPMDTESDGLQSQEPAGNINPPIEHQPSLVHRPLSPFGIRERLLPPPVPASHSQPQSGSCGSRHDRRSSSFTPITFRDGVSATLQYGSVPKPQNVAQIDATGGSMGIGLHALQKKHRPFDDDDDSDADTISDSEEERDVTTTGDVRIVEPPPPLPWESKKRKRHGIPQAELLTSGPPTSAWLDEYEDEKKDGSPSVDTLLKVLLESTSPAVNLDLQATLTAEKALCDTGLPSAAAQPEALETLTGTVASIETAYSLTKSDLVCVAQIVSEQSVTANPHVSAMRRRFDDARDAVDDATSVTIPRYIRDRLSRAIRLACPEAAYCDLADLALAKDAPARQATVPGKIPQGQPRPPQRLDNIPTGPDMFPLPAPYIRLHRGTDTWELLPACIPFWEPLGLGPAAGPKHLRAFCVFPFNEDLQRLVDQFLRDVGTAYESCKLGTHIHLRNVSELEQDNFKDGLAPVELSEDASLESVLRAYAATCTDLGKALSSILPGEERAIVVYILNPFTGRDAQQHLCACFWMLFQAHRERTSKSPLEQDNSDIFLQILPMNMVASFDAFVPLDARKMSVLAREVYDRCPPTSAPLLSDISAPLPNLAAPTVELASTAPKRLGFQLASEAPGDLLYEGSILHLAYAHSSDGMWLTACWIDSTGKHQSSSSFGLAGRTFAEVAHDVWEFTRTIMAARQVSWRVFIVAPGADLDPSAVQCWRSVAARPRSHPVCVTLLSTQEDPFLQLYRPCESSCYGGGGGSNAEVGVLTPASTPQGATFTSSPDVSGHTSNAPPTPAASETANSLPTDGTGDSDAHLMDMTDETWGVLLSTKLLSDHHASSSSRMAHGVLFQRGPASMPDSEHTDTGDKLPSLGVNLHWTIQVKSQGGVDEGSAKQAELTLRDVLRMYRGLTTLTNARSLIRSAAAAAGTGKSILPVHVAMATMGAEGLVGLAPVVDDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJA8</accession>
    <name>N1QJA8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_49929</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758765.1">
        <property type="nucleotide sequence ID" value="XM_016909141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJA8"/>
    <dbReference type="GeneID" id="27906278"/>
    <dbReference type="eggNOG" id="ENOG502SH4E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019101_0_2_1"/>
    <dbReference type="OMA" id="LTINSWG"/>
    <dbReference type="OrthoDB" id="4329349at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF2">
        <property type="entry name" value="SRPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="32"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF10644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="277" mass="31154" checksum="8F0EE83220CCC56B" modified="2013-06-26" version="1" fragment="single">MSSSSTQVHHDPSYMKEVWALFGVGVAVLMARFAVRIRTVGIRQFAGDDYMSLVVLACYVADAVTVTITYHKGSNLDFSEDDVNRLTRSQIKNVELGSKMQLLAWYTYVTLIWALKGCMLFFFSRLSFGLTREKFVKALVLCCVATYLAMFFTITFSCYPIRMHWQVTPKPPLRCTLRIQNFYVCTILNVITDAALLAVPIPMLWKLRVPLRKKITLACLLSSGIFIITAAIVRIVMSLQGNPNALTINRWGVRETIAGIIAVNAPMLAPLATRSFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJC9</accession>
    <name>N1QJC9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SGS-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_149750</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SGT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760031.1">
        <property type="nucleotide sequence ID" value="XM_016905748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJC9"/>
    <dbReference type="STRING" id="692275.N1QJC9"/>
    <dbReference type="GeneID" id="27902885"/>
    <dbReference type="eggNOG" id="KOG1309">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039532_3_1_1"/>
    <dbReference type="OMA" id="KSGPKNW"/>
    <dbReference type="OrthoDB" id="1898560at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06466">
        <property type="entry name" value="p23_CS_SGT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007699">
        <property type="entry name" value="SGS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044563">
        <property type="entry name" value="Sgt1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45862">
        <property type="entry name" value="PROTEIN SGT1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05002">
        <property type="entry name" value="SGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51048">
        <property type="entry name" value="SGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="4">
        <location>
            <begin position="168"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="SGS" evidence="3">
        <location>
            <begin position="297"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="126"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="250"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="357"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="256"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="305"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="326"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="361"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF11910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="395" mass="43435" checksum="98B961D73C6029D3" modified="2013-06-26" version="1">MAAQAARGKKALEAGNYEEAIKEYTDAIKESPTSPEFYTQRSVANQRAGHLEESLADAESAVLKALSRAKKEAITEAQFRRGVALYKLGRLGDAEFILNLVKQRDDKHKQADMWINKTKMDLAKLGQGDEKQKVTVTEKPSQPATTTTTTSTSTTVAVPSTAPERTPADKIRYDWYQNTEKVYFTLMAKGVPEDKCVVDITERSFSISFPTGADSNYDLHIEPLFASVHSDKCTTRVLPSKVEITLVKAQPGQKWHKLESDEPVPDSKKVDSVADSDAKNADPVKRAVLSDSSRGPAYPTSSKKGPKDWDKVAKEAMPTSGKPGAAEDDDDYEGGDEANHFFKKLFKGASPEMQRAMMKSYTESNGTALSTNWDEVSKGPVETTPPDGMEAKPWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJJ4</accession>
    <name>N1QJJ4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_57731</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765496.1">
        <property type="nucleotide sequence ID" value="XM_016909448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJJ4"/>
    <dbReference type="STRING" id="692275.N1QJJ4"/>
    <dbReference type="GeneID" id="27906585"/>
    <dbReference type="eggNOG" id="ENOG502QSAH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040959_2_1_1"/>
    <dbReference type="OMA" id="ETYMTDL"/>
    <dbReference type="OrthoDB" id="1914839at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd24142">
        <property type="entry name" value="ACL4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="49"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="354"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="360"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF17375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="388" mass="42874" checksum="39B14E42B22F5314" modified="2013-06-26" version="1">MASQEPEASPEQLYASALELVEQSQPAEALVAAKKLWSHVKNGSVTDKLPAATLLGDISIELGAVDSARRYFEQAVLLDPDGKVPETLGGGADKFLWLAQLCEEGGKQSVHWFEKGVQALHYEIAALESGTGLPPGIDDEALLLLRVEKKRKLANALCGIVEVYMTDLSWEDDAEARCENLITEAMSVEDDTSAEVLQTLASVRLSQDRREDAQSALQRSLAMWMDLEPEDPAVPDFPTKVSLARLLMEADLKMEAMEVLHRLVQEDDQSVEAWYLGGWCQYLLAEPHGIIADARNGDAMDTGAPVTNQEQNARAKKGSRRWLTTSLKLYNQQEYEDHRLFDHAHELVEELNAVLGPENEQAEGGDEESEWEGIGDDGEDEDEQMQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJV9</accession>
    <name>N1QJV9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_149869</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat striatin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760216.1">
        <property type="nucleotide sequence ID" value="XM_016905822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJV9"/>
    <dbReference type="STRING" id="692275.N1QJV9"/>
    <dbReference type="GeneID" id="27902959"/>
    <dbReference type="eggNOG" id="KOG0642">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009046_0_0_1"/>
    <dbReference type="OMA" id="SKCSQEV"/>
    <dbReference type="OrthoDB" id="727118at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013258">
        <property type="entry name" value="Striatin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051488">
        <property type="entry name" value="WD_repeat_striatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653:SF0">
        <property type="entry name" value="CONNECTOR OF KINASE TO AP-1, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653">
        <property type="entry name" value="STRIATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08232">
        <property type="entry name" value="Striatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Striatin N-terminal" evidence="9">
        <location>
            <begin position="28"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="572"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="772"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="99"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="179"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="306"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="593"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="719"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="54"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="319"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="593"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="621"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF12095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="851" mass="91968" checksum="625D7C59852701C5" modified="2013-06-26" version="1">MAYQQQGGLGNHGGGGAEHHGPQGTEYTLQGVMRFLQIEWHNHERARNAWDIERAEMKAKIAKQEGESRQAKRINEQLERQVRMLEMALKHERAQKLAPNGISAAVMPEPTAATDDVPKGKKEEGGGKNGQKQEKPDFAPHNSFLETSEQHDSSEKAREEYLDQTTKYLKNCMKEIQYLLTPPQHPPPPQMLPNGNISGLPDAPHSLQDIYDLQYGDQARQGYRNGRAQGQILPQQQQLPNHQPSQVPSSIVQPAVQRADSRGMAYTEYTNHAQQPVELLQQQQQQQTPQASVQYEEQVENITHTFDREGREVRANESQQLQQRPARQQAEADGWTFDEEPASQTDAPSADVLPPRRPDTDLFPSAASHSQLSAKSPPRTGLHSRRKSSGSQSVGRRRSSQGKNQIDELAHALESDPTQFKVKFELRGHLDVVRSVIFSGGGSPSEPEVCTAGDDGTIKRWIVPATYQNYNPGNKDSSLDIQAIFTHRGHEGVVTSLAAPPASTGFSTGGRAPGEGWIFSGGQDATVRVWERGRVDPKATLEGHTDAVWAVCVLPASVGVVFGPQSGNFGGPDRLLLVSGSADGTVKVWAVSAPPQSASPATGSRRGVGGSRRHSVTSGSNYPTSPQPSVASTTPFSYTLVHSINRPGDHEASPTSICPLSPSGETFVVSYTDSSVLIFDTRTGEEIIGMASGETYDGTPNTSINAVVATSSSLEQHSGGALDAATRGLDSEEVGGGATGGREGLEGVVITGHEDRFVRFFDANSGQCTYTMLAHPSAISALSLSKDGREAVSAGHDASIRFWSLEKRICTQDITNHRAMRGEGVCDVCWSQDGRLVISAGGDGVVKVFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKI0</accession>
    <name>N1QKI0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Signal recognition particle 54 kDa protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SEPMUDRAFT_149615</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Signal-recognition-particle (SRP) assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum (ER) membrane. SRP is required for the cotranslational protein translocation for ER import and preferentially recognizes strongly hydrophobic signal sequences. It is involved in targeting the nascent chain-ribosome (RNC) complex to the ER and is proposed to participate in the arrest of nascent chain elongation during membrane targeting. SRP54 binds to the signal sequence of presecretory protein when they emerge from the ribosomes. SRP54 interacts with the scR1 RNA and mediates the association of the resulting SRP-RNC complex with the signal recognition particle receptor (SR) via its alpha subunit SRP101. Both, SRP54 and SRP101, are locked in their GTP bound forms in the SRP-RNC-SR complex, which dissociates upon transferring the signal sequence to the protein-conducting channel (translocon). After signal sequence transfer, SRP54 and SRP101 act as reciprocal GTPase-activating proteins (GAPs), thereby resolving their association.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Fungal signal recognition particle consists of a 7S RNA molecule (scR1) and at least six protein subunits: srp72, srp68, srp54, sec65, srp21 and srp14.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The M domain binds the 7SL RNA and the signal sequence of presecretory proteins.</text>
    </comment>
    <comment type="domain">
        <text evidence="13">The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit srp101. The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another. SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759827.1">
        <property type="nucleotide sequence ID" value="XM_016905664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QKI0"/>
    <dbReference type="STRING" id="692275.N1QKI0"/>
    <dbReference type="GeneID" id="27902801"/>
    <dbReference type="eggNOG" id="KOG0780">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009301_6_1_1"/>
    <dbReference type="OMA" id="GMTGQDA"/>
    <dbReference type="OrthoDB" id="10250817at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006616">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17875">
        <property type="entry name" value="SRP54_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.30:FF:000003">
        <property type="entry name" value="Signal recognition particle 54 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000022">
        <property type="entry name" value="Signal recognition particle 54 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="entry name" value="Signal recognition particle, SRP54 subunit, M-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006325">
        <property type="entry name" value="SRP54_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01425">
        <property type="entry name" value="SRP54_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 54K PROTEIN SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF5">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="Signal peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10 13" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="14">
        <location>
            <begin position="269"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMF11706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="519" mass="55582" checksum="D15CC657DE722A99" modified="2013-06-26" version="1">MVLQDLGRRINASLNDITRAPTLDEKAFDGMIKEICSALMEADVNVKLVANLRKTIKSAVKFNELPAHANKKRIIQKAVFDALVDIVDPHQKPYEPKKGKSNVIMFVGLQGAGKTTTCTKLARWYQARGFKTCLVCADTFRAGAFDQLKQNATKAKIPYYGSLTQTDPVVVARDGVNQFKKEKFEIIIVDTSGRHHQEDALFAEMVEIQQAVSPHQTIMVLDASIGQAAEAQSRAFKDTADFGAIIITKTDGAAAGGGAISAVAATHTPIVYIGTGEHLLDLEKFNPQSFVSKLLGMGDVQGLMEHVQTLKLDQKETMKNITEGRFTVRDLRDQIQNISKMGPLSKMAGMIPGLSGMMGGMDDAEGGDKLKRMIIICDSMTQKELDSDGKIFVDQPSRVTRVARGSGSSVREVEELLAQQKMMAGVAKKVKGGMANMQKAQGALGGANQKSQMAAMQKRMQAMGGAGRGGAGGMPDMGSLMKMMGGGGGGMPDLSGMDMQKMMSMMGGMMGGGGAGRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKQ1</accession>
    <name>N1QKQ1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_146771</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765962.1">
        <property type="nucleotide sequence ID" value="XM_016903855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QKQ1"/>
    <dbReference type="STRING" id="692275.N1QKQ1"/>
    <dbReference type="GeneID" id="27900992"/>
    <dbReference type="eggNOG" id="ENOG502SI2P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065434_0_1_1"/>
    <dbReference type="OMA" id="IASHNLY"/>
    <dbReference type="OrthoDB" id="5352400at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF17841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="299" mass="33625" checksum="D4DF134C62AD7C71" modified="2013-06-26" version="1">MIILAKQWRMPKFFVVLLLVELPLTVAMLTLMGIAHPNTYRTKLWQNGFDKGFNSAPNSILYDYANWRPAHVPEIWSHGMTEFNVVISILSMFLLLAKSTMFVMHIFIPGLSSLVHAVLVALYAVSVYNQSRPDMSDINHLSPGMPWYLSKGCDYATAGNRGFCLQARASFGVTIVMLALFVVYLGYSAWSSIPTPQERLEREADRRSDLEMKKLSMYGLDDDLTKEERREHNRQLFLNLPKTPSFGGANNPMTPRTMAFTQLNGGEAPPMVNVSHAGPSRALPFRDFHHGSTAVPDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKR9</accession>
    <name>N1QKR9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Px domain containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_145528</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764334.1">
        <property type="nucleotide sequence ID" value="XM_016903108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QKR9"/>
    <dbReference type="STRING" id="692275.N1QKR9"/>
    <dbReference type="GeneID" id="27900245"/>
    <dbReference type="eggNOG" id="ENOG502R4GW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024451_0_0_1"/>
    <dbReference type="OMA" id="MINGMMR"/>
    <dbReference type="OrthoDB" id="2117459at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047168">
        <property type="entry name" value="LEC1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024554">
        <property type="entry name" value="LEC1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024555">
        <property type="entry name" value="PX-associated"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47185:SF2">
        <property type="entry name" value="FUNGAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47185">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN YPR097W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12825">
        <property type="entry name" value="DUF3818"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12828">
        <property type="entry name" value="PXB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX-associated" evidence="3">
        <location>
            <begin position="10"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="2">
        <location>
            <begin position="169"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="2">
        <location>
            <begin position="361"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="620"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF16213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="668" mass="74846" checksum="FC3F419EE8480B68" modified="2013-06-26" version="1">MATPAPGTLTLSADQSKALFDILTHQQTYQEIEDFKYPGAIHNYGPPFQKNVASPQSPILQTLVSKFLIKLPGLRDVSPEFWKGRVDALVQELSEAELSESYDKGLLGIRKTLATAISALLEYPARGVLGGFPKEEVKRSTTYDTTNPEDVLQAWQDCVQQAVYGNLIDELFAKAAETDDLTKHDSLVQGMHEFMVVNIASIMHYTLVLSPEGPTMLRMLSSVHNLIPYTIIRQTLKVGNVATMLSGVMRIVLAKASVATVTNWIGLSSGADEGMNLMQQIMSQVLSWDKRELKKRAEKIEKAKDGPPKDVLAEIKNWISRSRQEHEETRKHSQEQNMSIVAMILALSSVSSEMSPAQHAKAQEYLSLQLAIRDRQQIVKVLCQRHPDILTAAIRDAVDAYTPMIRHVHQAVNLSDTLWDFERFLTDLLKISIVNDTKKEQQGQQQQSQQPQKAPSVEDFVDLLHRHQSSCHKFIHQFAKNGKEMTEWWKEYIHMAAANFRKNDTPPPSESIVSDKMTTGGLQQALETEFSHLSPADQKTIHEELDAWKSYIDQLHHASTARITAVIKRTHSTPFGPGAYLARWQQLLDDTPITPATAQGPVRHGADRAVKENSRANIEGADAHRDGSQEAEQQQIQKAVADKMPTAPVCEAVSRLLWPKFRQALISQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>N1QL37</accession>
    <name>N1QL37_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_149743</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760017.1">
        <property type="nucleotide sequence ID" value="XM_016905742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QL37"/>
    <dbReference type="STRING" id="692275.N1QL37"/>
    <dbReference type="GeneID" id="27902879"/>
    <dbReference type="eggNOG" id="KOG0446">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008964_5_2_1"/>
    <dbReference type="OMA" id="IQRRKEC"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000473">
        <property type="entry name" value="Vacuolar sorting-associated 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF220">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="8">
        <location>
            <begin position="35"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="7">
        <location>
            <begin position="618"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="83"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="545"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="564"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00073589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF11896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="705" mass="77956" checksum="DD6CF0E8479B9539" modified="2013-06-26" version="1">MAQANPNAINVNDPGLITLVNKLQDVFTTVGVQNPIDLPQIAVVGSQSSGKSSVLENIVGRDFLPRGTGIVTRRPLILQLINRTPFKPSDKPQENGATGGDAVEGTDDKEANTSEWGEFLHIPGQKFYDFGKIRDEIVKETESKTGRNGGISPAPINLRIYSPNVLTLTLVDLPGLTKVPVGDQPRDIERQIREMVLKQISKPNAIILAVTAANTDLANSDGLKLAREVDPEGQRTIGVLTKVDLMDEGTDVVDILAGRIIPLRLGYVPVVNRGQRDIETKKAISYALENEKNFFENHRAYRNKASYCGTPYLARKLNLILMMHIKQTLPDIKARIAASLAKYSAELAQLGDSILGDASNIILNVITEFSNEYRTVLEGHSAELSSVELSGGARIAFVYHELYNNGIKAVDPFDQVKDIDIRTILYNSSGSSPALFVGTMAFEVIVKQQIKRLEEPSLKCVSLIYDELIRILGQLVNKPMYRRYPALKEKLHAVVVGFFKRAIEPTNKLVRDLVAMEACYINTGHPDFLNGHRAMAIVNEKHNAAKPVQVDPKTGKPLPLSAQPPRSASPSLDMSNGDAGFFGSFFASKNKKKMAAMEAPPPTLKASGTLNDKESQEVEVIKLLIASYFSIVRRTMIDMVPKAIMLNLVERTKDEMQRELLQHLYGMQENSDLLKESDYTTKRRKECQQMVESLGRANEIVSQVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1QLZ4</accession>
    <name>N1QLZ4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA primase large subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_146345</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the eukaryotic-type primase large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765393.1">
        <property type="nucleotide sequence ID" value="XM_016903589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QLZ4"/>
    <dbReference type="STRING" id="692275.N1QLZ4"/>
    <dbReference type="GeneID" id="27900726"/>
    <dbReference type="eggNOG" id="KOG2267">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026253_1_0_1"/>
    <dbReference type="OMA" id="RINYKPW"/>
    <dbReference type="OrthoDB" id="421393at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07322">
        <property type="entry name" value="PriL_PriS_Eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.80:FF:000003">
        <property type="entry name" value="DNA primase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058560">
        <property type="entry name" value="DNA_primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016558">
        <property type="entry name" value="DNA_primase_lsu_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007238">
        <property type="entry name" value="DNA_primase_lsu_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537:SF3">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04104">
        <property type="entry name" value="DNA_primase_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26466">
        <property type="entry name" value="DNA_primase_lrg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009449">
        <property type="entry name" value="DNA_primase_large_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0639">Primosome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA primase large subunit C-terminal" evidence="11">
        <location>
            <begin position="296"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR009449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR009449-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF17272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="507" mass="58927" checksum="3732BDBEB2D9708E" modified="2013-06-26" version="1">MLAIAHAPRIDAKKRAVHHKQAPFQTATFAEQDYAHRMNFYIIPPTGDVTLEQFEEWAIARLKVLAELESCHFRNRSPAETEEYMRPILDKHMPLSSNSARHNDIPMQRKRDHYSHWTLRLAFSSTQDLRQRFARLESQLFKLRIQQDDLRERRAFIEALPMSWETVGEDEKAQLLEELKAATGFFAKTDEENWFKCEWENVPELVERRQVLLKKGKAYVHVREQMSMVVNEFSRQLESGLEVAARFLPRMDEDNRLAPILHHLSQSFVAPDAGYSEESSLGDMTNVTAASIDSYSQHFPLCMQNLHRELKKNSHLKHYSRLQYTLFLKGLGLNLQECILFWRRSFKLVTDDKFKSEYLYNIRHAYGDVGGDSNRRGRGYTPYSCNKLLTEPLPASGQNHGCPYRTYSPDNLITLLQNVGVNDRELLKGVREDVGRQRYHIACNRVFEAAHKNEIKKVKDESLWPASELDTILHPNTYFKRSFQLKNLGKIRKGDIGVDEPMPSSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1QMB3</accession>
    <name>N1QMB3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">agmatinase</fullName>
            <ecNumber evidence="4">3.5.3.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_146486</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>agmatine + H2O = urea + putrescine</text>
            <dbReference type="Rhea" id="RHEA:13929"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:58145"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="3.5.3.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="5">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the arginase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.11" evidence="4"/>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765578.1">
        <property type="nucleotide sequence ID" value="XM_016903682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QMB3"/>
    <dbReference type="STRING" id="692275.N1QMB3"/>
    <dbReference type="GeneID" id="27900819"/>
    <dbReference type="eggNOG" id="KOG2964">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039478_1_1_1"/>
    <dbReference type="OMA" id="CIDAGFV"/>
    <dbReference type="OrthoDB" id="288726at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008783">
        <property type="term" value="F:agmatinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033389">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via agmatine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019627">
        <property type="term" value="P:urea metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11592">
        <property type="entry name" value="Agmatinase_PAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.10:FF:000006">
        <property type="entry name" value="Agmatinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358:SF30">
        <property type="entry name" value="AGMATINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="ARGINASE/AGMATINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110991" description="agmatinase" evidence="8">
        <location>
            <begin position="26"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00050304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00066392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR036979-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF17457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="404" mass="43453" checksum="7BA884D8E70E0FED" modified="2013-06-26" version="1">MLNIFSPPILTAAAAAAATVVLAHGDHHDQEPLEGPHKKLWYNTLPGDGGTQADSVFSGISTFGRLPYSPCLATEDVKYDIAFIGAPFDTGTSYRPGARFGPSGIRQGSRRLNLYGGYNVPLDANPFASWASVVDCGDVPVTSYDNTWALHQIEEGHNSILMREPATDAKEPGISKHGKTLPRVITLGGDHTITLPLLRSMNRAYGPITVIHFDSHLDTWRPKVFGGSPSKVASINHGTYFFHAAQEGLLRNDTNIHAGIRTTLSGLSDYDNDGYCGFVISEAREIDTIGTEGIIKKIHDRVGHTNPVYLSIDIDTLDPAFAPATGTPETGGWSTRELRTIIRGLKGINLVAADIVEVAPAYDTNAELTTMAAADTLYEVMSLMVLNGPLTVSNSSRAPAKEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>N1QN07</accession>
    <name>N1QN07_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_146081</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765085.1">
        <property type="nucleotide sequence ID" value="XM_016903444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QN07"/>
    <dbReference type="STRING" id="692275.N1QN07"/>
    <dbReference type="GeneID" id="27900581"/>
    <dbReference type="eggNOG" id="KOG0877">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065898_0_2_1"/>
    <dbReference type="OMA" id="PYEEWSD"/>
    <dbReference type="OrthoDB" id="10253125at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045903">
        <property type="term" value="P:positive regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000002">
        <property type="entry name" value="40S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000004">
        <property type="entry name" value="40S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_uS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_uS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005711">
        <property type="entry name" value="Ribosomal_uS5_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_uS5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_uS5_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01020">
        <property type="entry name" value="uS5_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718:SF4">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="RIBOSOMAL S SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S5 DRBM" evidence="9">
        <location>
            <begin position="92"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF16964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="269" mass="28966" checksum="E4B6994505141D1E" modified="2013-06-26" version="1">MADRGGAAPAAGARGGGFGSRGDRGGGDRGGRGRGRGRGRRGGAKSDEKEWQPVTKLGRLVKAGKIKSMEEIYLHSLPIKEYQIVDFFLPKLKDEVMKIKPVQKQTRAGQRTRFKAIVVIGDSEGHIGLGIKTSKEVATAIRAAIIIAKLSVVPIRRGYWGTNLGDPHSIPVKESGKCGSVTVRLIPAPRGTGLVASPAVKRLLQLAGVNDIYTASSGSTKTLENTLKATFVAITNTYGFLTPNLWKETKLTRSPLEEYSDVLRDGKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>N1QN47</accession>
    <name>N1QN47_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_34812</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016766008.1">
        <property type="nucleotide sequence ID" value="XM_016908583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QN47"/>
    <dbReference type="GeneID" id="27905720"/>
    <dbReference type="HOGENOM" id="CLU_2948364_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF17887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="55" mass="6440" checksum="64FBAAE17A7E2A0F" modified="2013-06-26" version="1" fragment="single">QRVEYLIDLTKLFAAATAVIRTTKGPTIYLVLIYYNKLFDILEEAIKRLKNKRIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNZ0</accession>
    <name>N1QNZ0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FIST domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_78559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765975.1">
        <property type="nucleotide sequence ID" value="XM_016910199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNZ0"/>
    <dbReference type="STRING" id="692275.N1QNZ0"/>
    <dbReference type="GeneID" id="27907336"/>
    <dbReference type="eggNOG" id="ENOG502SB4N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014048_2_1_1"/>
    <dbReference type="OMA" id="WELGTIP"/>
    <dbReference type="OrthoDB" id="1744869at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF17854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="508" mass="54760" checksum="7A51B898FB2EA723" modified="2013-06-26" version="1">MGTVAVQTPQDTNIREVISKINPEPRGKPSRPNEAPSLLVLLVTPSFAQHALDTDLPLKVLERFQENPTISKPLDALIAVVDRLPVPRNAPDGVEGIGYAFITNPSPSHVDSQLPLQPNASKPGSLSFDLSTVSHHGPRRVIAQMPLAQTIFSTGLPSTLIYTRYQFDPLSGHLRTQTSQRLESVTLPMPEDVSAGSVRLRAPLIPLTFPRLVVSSMGNIVRKLSPLPQPHENNSAESNSGDGQAASPTVFSASQELEAAVSTYFAARGMSPEPVQVWALIMPEDAGQKYPFRSLLNSVLKNNAKAIQQMMVDDRTNPMASGRLLGALSVGARLCKVLSGGGGWGKKAGLLSLDPDSQYSTRELRGDHGWDFTFEGDTTEEMMAAGRKQALGEIVKEGERIVFFLLGPKNLLKDPGADASSYFPAFVLGALPSSTENEQFDAEARHESGEAAGLTHYPWRFGALSEGGMALNVSQPGGPTTQTKVDAPYAVMTAYCFREEKPVAELNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>N1QP20</accession>
    <name>N1QP20_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome biogenesis protein ERB1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Eukaryotic ribosome biogenesis protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ERB1</name>
        <name evidence="10" type="ORF">SEPMUDRAFT_34155</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat BOP1/ERB1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF18004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016766125.1">
        <property type="nucleotide sequence ID" value="XM_016908563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QP20"/>
    <dbReference type="STRING" id="692275.N1QP20"/>
    <dbReference type="GeneID" id="27905700"/>
    <dbReference type="eggNOG" id="KOG0650">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011390_0_1_1"/>
    <dbReference type="OMA" id="MRPAKGE"/>
    <dbReference type="OrthoDB" id="5571054at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000061">
        <property type="entry name" value="Ribosome biogenesis protein BOP1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03027">
        <property type="entry name" value="BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028598">
        <property type="entry name" value="BOP1/Erb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012953">
        <property type="entry name" value="BOP1_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605:SF0">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1 BLOCK OF PROLIFERATION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08145">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01035">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BOP1 N-terminal" evidence="9">
        <location>
            <begin position="77"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="350"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="678"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="231"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF18004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="703" mass="79515" checksum="B05CDA7727DA9428" modified="2013-06-26" version="1">MGTDTGRDIQNLSKSPDMSMKPLELHDRTKTSNYRVEEDANGNERYVYQDIDPAYDTDDSDAPVTSNTIGNIPLSYYDAYPHIGYDINGKKIARPAKGQALDSLLESIDLPEGWTGLTDPTTGKPLQLSRDELETLKKLTRNEQPGDGYDPYPDYVEWFTGKGMEEVMPLSAAPEPKRRFVPSMHEHKRVMKMVKAIKEGRIKPFRAPDEEEREREEAELDYASYDVWANEAPKPDHPMNMPAPKLPPPGYEESYHPPPEYLPDKQEREQWEKTDPEDRDRDFLPRDHSALRRVPGYDELLHERMNRCLDLYLAPRVRRSKLNIDPESLLPKLPDPAELKPFPTTCHKTFSGHEGQVRSVAVDPSGTYIASGGVDGTVRIWTVETTRQVRRIRLSQSESVNVVAWRPGQGAFILGACCGDTVYFMTPQSEEISEEVQEHAHEIIDAGFGYEAANIAKTADGVPKPKAATWARPPQNLQDKGILLTLTLRSTPKTLVWHRRGEYFATVCPQSSSTSTSVAIHTLSKHQTQHPFKRPKGLAQTVCFHPSRPLFFLATRQRIRIYDLQAQKLEKELQPGARWISDISLHPMGDNLLVSSYDKRLLWHDLDLGSTPYKTLRYHTKAIRSVKFHNSYPLFADASDDGTLQVLHGKVFGDSMENATVVPLKILRGHKIKSDLGVLSVDWHPTEAWLVSGGADGTVRLWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M3ASZ3</accession>
    <name>M3ASZ3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_53667</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756755.1">
        <property type="nucleotide sequence ID" value="XM_016909270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3ASZ3"/>
    <dbReference type="STRING" id="692275.M3ASZ3"/>
    <dbReference type="GeneID" id="27906407"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_1"/>
    <dbReference type="OMA" id="WGQRFPP"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF2">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF08634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="258" mass="27862" checksum="4062CCF65965A1FE" modified="2013-05-01" version="1">MPYTLQGRNVLITGGSRGLGAEIARKFAAEGSNIAINYHSKEAPAKELSRELESQYHIKTTVLQGDAGNVSDIERCVRETVESLGGLDIIIGNAGWTRFSQFDNLDDLSYDEWDKCWNTNVKGNHALLKTAMPIFQANPDGGVFIMTSSVAGKSLSGSSMAYSVTKAAQIHLMKCLANTQGPKSGGKVRVNAILPGLLLTDWGNLYGEERIAGLKNMAALKRETKLDDCAQTFVDVAKNTSWTGQAIHIDSGLNVGHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M3AVS3</accession>
    <name>M3AVS3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carbohydrate-binding module family 50 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_151189</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758297.1">
        <property type="nucleotide sequence ID" value="XM_016906661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AVS3"/>
    <dbReference type="STRING" id="692275.M3AVS3"/>
    <dbReference type="GeneID" id="27903798"/>
    <dbReference type="eggNOG" id="ENOG502SCJ7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076125_0_0_1"/>
    <dbReference type="OMA" id="ECVIRPF"/>
    <dbReference type="OrthoDB" id="2107166at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008932">
        <property type="term" value="F:lytic endotransglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33734">
        <property type="entry name" value="LYSM DOMAIN-CONTAINING GPI-ANCHORED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33734:SF22">
        <property type="entry name" value="MEMBRANE-BOUND LYTIC MUREIN TRANSGLYCOSYLASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004030966" evidence="2">
        <location>
            <begin position="19"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="57"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="131"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="188"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF10176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="237" mass="24125" checksum="9B09C927E87D9E35" modified="2013-05-01" version="1">MKSYIFAAAALVGAVAQGAVIRREDCDETTKAPGGPVVSTAETKPGNTLPCGATSSSEYTVKAGNTLFQISDETGVGVCDIAAASGIDNINLIYPDQILTIPIGCTTTDNTTCVTTPDTPATDTCVKGPPPTYTVVSGDTLGAIAKDFEITTNALISANSQISNPDVISIGQVINVPICPGSSCKSVDDYTIVSGDTFFDLASKSQTTVGQIKASNPGVKPETLAVGQVIKLPTGCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>M3AXJ4</accession>
    <name>M3AXJ4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="1">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_150389</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="1"/>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759581.1">
        <property type="nucleotide sequence ID" value="XM_016906140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AXJ4"/>
    <dbReference type="STRING" id="692275.M3AXJ4"/>
    <dbReference type="GeneID" id="27903277"/>
    <dbReference type="eggNOG" id="ENOG502QSIQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018461_0_0_1"/>
    <dbReference type="OMA" id="HMRITVF"/>
    <dbReference type="OrthoDB" id="2248014at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02662">
        <property type="entry name" value="Peptidase_C19F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF904">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="4">
        <location>
            <begin position="49"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="481"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="483"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="503"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="513"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF11460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="633" mass="69852" checksum="36E925BD5A13FF1E" modified="2013-05-01" version="1">MPDRPLTIATYAAGASLAAITLVYVFGPTFFLDSDDASSTKSSRKKGVVGLVNPANDCFINSVLQALAGLPDLRAFLIREVHRRALDGPAVYEDLTAVFEEQAKRGEGAKKTPEWQLAGLQQGLVTAGLKDVLDALNERPIYKKTISAQGFIRCVETSFRTRISRSQQDAQEFLQVVVERIAEEYYAGRRARRRIRQTEAQSYITVEPPAEDAANTEEGEAGALRPRDSKMEKVNTDQFNSVLQTVPEESDSDKDENIFPLQGKLESQVECSHCHFKPKPSISTFLTLTLNVPHEQTSTTLSECFDGMFKVEHIDDFKCECCRLTHAISINDRILARSDLSPEDRAKLEDDNMKLQQALDEDPEKPPSDVKLPDVSTAPKRKIARHTRLSEFPKILSVHLSRSVWDPSATSSKNMAKVSFPESLPLGGLLDRKQYRLLGVVTHKGGHNSGHYESFRRQVLPQPFSTPTTLGRQGVYSIAASPAPSTVNSPRLSASTADFPRDSTVSSADSQFLSTPSSSSLSTIVPSSDKRKSTNASVPFDSIPAPGLPTPPSTSNLGDTSKADETTSPRRSGSFRNFRGAVQRKTAKKTAAASSDRWWRISDDKIKESKTSEVLGMQKEVYLLFYEMVRTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M3B0U2</accession>
    <name>M3B0U2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_148705</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761508.1">
        <property type="nucleotide sequence ID" value="XM_016905097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B0U2"/>
    <dbReference type="STRING" id="692275.M3B0U2"/>
    <dbReference type="GeneID" id="27902234"/>
    <dbReference type="eggNOG" id="KOG0773">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052550_0_0_1"/>
    <dbReference type="OMA" id="NSTHVRR"/>
    <dbReference type="OrthoDB" id="10056939at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
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    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 4" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="6">
        <location>
            <begin position="350"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="4">
        <location>
            <begin position="352"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="163"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="195"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="259"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF13387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="429" mass="47914" checksum="3FDEA3D90BAB5028" modified="2013-05-01" version="1">MESLTLNDGTPYQRHYHYRDQKPRSPRLPTPDVSRSSRETLVGPYDNGPFFLRPSSGERSLGIPNGPTHYRRDSRNTVIPHSPPYLNGEGQKPSLPPLKTVLGNSISSPPRTPSPGGSPGQLAPREPSYITSTYKPPSLYPNKKQRMEPLYSGVAANGPRFAPSTTLEPTTSASSMRSSVQFPPMNSTHVRRTHAQSVGSPPWSSQDASARSGGARTHENAPGQYQNADQPPVEPSFPRRNPFTGTAPDPFARQMRDSFGQSGDRPSSRRSSVSTYAMYPPPSSFDREQPRPSPYSAGGYAMRDGYSDPRDPIRYGRPEEHQDCQPGFPAQPYQSNVPAYFMPSHYEYQHGKARKRSNLPKQSTEIMKTWFDQNIANPYPSEEQKAVFSNATGISMTQVSNWFINHRRRCPELRDKREKSRGGGRDSDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M3B1M8</accession>
    <name>M3B1M8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_148920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761828.1">
        <property type="nucleotide sequence ID" value="XM_016905228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B1M8"/>
    <dbReference type="STRING" id="692275.M3B1M8"/>
    <dbReference type="GeneID" id="27902365"/>
    <dbReference type="HOGENOM" id="CLU_2499302_0_0_1"/>
    <dbReference type="OrthoDB" id="5337308at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF13707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="86" mass="9406" checksum="8CE21A8D1503A733" modified="2013-05-01" version="1">MVTRQPTAEAVGEWPGMSFGIEAPQALAALGCPNGAGLAWLLIQHKETLGSRMVDRVHIFDCKRYLGNGRGEWCLYLHITDSPVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2022-12-14" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>M3B1Q9</accession>
    <name>M3B1Q9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_84867</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761858.1">
        <property type="nucleotide sequence ID" value="XM_016910368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B1Q9"/>
    <dbReference type="GeneID" id="27907505"/>
    <dbReference type="HOGENOM" id="CLU_2747171_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF13737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="71" mass="7571" checksum="29F91B169AB2CF45" modified="2013-05-01" version="1" fragment="single">MRKKTEDERGSRGKVVVAVGGEDGDVEVEEVAEVGIGARDTEPNSPAVGSTMELAIALHFCLRISVALWKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M3B287</accession>
    <name>M3B287_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_149022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762003.1">
        <property type="nucleotide sequence ID" value="XM_016905290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B287"/>
    <dbReference type="GeneID" id="27902427"/>
    <dbReference type="HOGENOM" id="CLU_1485510_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF13882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="182" mass="20039" checksum="7762652BC4182E1B" modified="2013-05-01" version="1" fragment="single">PGLAWSRQLVWSCQCLHLQTRCACSSSSFQPFHTTTPPLYTNSLSLSLSLSLLLRLSVSPSALLFYLTPLGTPGVTIHRAAPHRTAPYSLLPLHSSLPPLTPHSPLTTDETRSATDLDFPIRTPPPSTHPSIAALRQPSIHCRAIASCLLRRHYSIQAGAQLVSAHDTHVQKHDRRDDERGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M3B778</accession>
    <name>M3B778_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">26S proteasome regulatory subunit rpn-8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_147517</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M67A family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763828.1">
        <property type="nucleotide sequence ID" value="XM_016904348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B778"/>
    <dbReference type="STRING" id="692275.M3B778"/>
    <dbReference type="MEROPS" id="M67.973"/>
    <dbReference type="GeneID" id="27901485"/>
    <dbReference type="eggNOG" id="KOG1556">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027018_3_0_1"/>
    <dbReference type="OMA" id="HAMSIKT"/>
    <dbReference type="OrthoDB" id="10256771at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd08062">
        <property type="entry name" value="MPN_RPN7_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000004">
        <property type="entry name" value="26S proteasome regulatory subunit rpn-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033858">
        <property type="entry name" value="MPN_RPN7_8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF7">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="5">
        <location>
            <begin position="16"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="317"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="318"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF15707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="370" mass="40922" checksum="EBD99B8CDF9CBF51" modified="2013-05-01" version="1">MPATTAETLQLVNRTVSVAPLVLLSAADHYGRSAKGTRKRVVGVLLGQNDGKSVRVSNSFAVPFEEDEKDPSVWFLDHNYVESMNDMFKKVNAREKLIGWYHSGPKLRASDLEINELFKRYTPNPLLVIIDVQPKEVGVPTDAYFAVEEIKDDGTTTSKTFVHTPSTIEAEEAEEIGVEHLLRDIRDVAVGTLSTRITSQLESLQGLHLRLQDIGKYLQKVIDGDLPVNHAILGNLQDVFNLLPNLSTPNEVGKDLPSLNGIVNGGVGVSGGHTENSELARAMSIKTNDQLMSIYLSSLIRAITAFHDLIENKIQNKRQQEDEDAKKDEDKKDKELKKEEKLMLNGTSEKGEDATKEGAKKESPPSKKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M3B8I5</accession>
    <name>M3B8I5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_147806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF16167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764288.1">
        <property type="nucleotide sequence ID" value="XM_016904536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B8I5"/>
    <dbReference type="STRING" id="692275.M3B8I5"/>
    <dbReference type="GeneID" id="27901673"/>
    <dbReference type="eggNOG" id="ENOG502RZMU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042688_3_0_1"/>
    <dbReference type="OMA" id="IPIEHRY"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G13140)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF16167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="32178" checksum="779EA1A8D1FA492C" modified="2013-05-01" version="1">MSTQTMQATKVSVTDDIPIPRGEAHSTLVFYAPPADGGVPFNYIETPPPGLPQRNFGEDSHEITLQDIRGRESEFDMNERGFGVLQNVSSGMQNADFNHDEKIEKTYYPEVESLLLDKVPGAKRVFIFDHTVRRSDPNAKRAPVNRAHIDQTTKSANLRVDYHMGDEAEALKNDRVRLINVWRPLNGPVVASPLAYADSRTVPDDDIVPVEHRYPHRTGETAGVKYTPNGQWYYWSGMKNDERILLQCYDSKDGARTPHSAFVDPRTKPDWPGRESIEVRALVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M3B8J8</accession>
    <name>M3B8J8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding TFAR19-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_124260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PDCD5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF16182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764303.1">
        <property type="nucleotide sequence ID" value="XM_016901903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B8J8"/>
    <dbReference type="STRING" id="692275.M3B8J8"/>
    <dbReference type="GeneID" id="27899040"/>
    <dbReference type="eggNOG" id="KOG3431">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122978_1_0_1"/>
    <dbReference type="OMA" id="MQYEMQK"/>
    <dbReference type="OrthoDB" id="10252486at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.140">
        <property type="entry name" value="PDCD5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002836">
        <property type="entry name" value="PDCD5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036883">
        <property type="entry name" value="PDCD5-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10840">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10840:SF0">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01984">
        <property type="entry name" value="dsDNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015730">
        <property type="entry name" value="TFAR19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46950">
        <property type="entry name" value="Double-stranded DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="13"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF16182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="142" mass="15397" checksum="EBDD449325307926" modified="2013-05-01" version="1">MSDSDLEAIRQARLQQLQSQQSSAPSGGGGNASQEDQQKAAAAEQKASILGQILEPFAADRLGRIRMVNAQRAEDVENRLIMLARSGQLRQRVTEEQLKDILGAVAKQTEERGGDAGVGKVVVQRRKGGWDDDDLDDLLGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>M3BQV2</accession>
    <name>M3BQV2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_121268</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756609.1">
        <property type="nucleotide sequence ID" value="XM_016901676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BQV2"/>
    <dbReference type="GeneID" id="27898813"/>
    <dbReference type="HOGENOM" id="CLU_2814050_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF08488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="67" mass="7559" checksum="E60C23367F9FC16D" modified="2013-05-01" version="1">MASRKAQFPPVKNAFRGWQQLASGIIHRSSCISNHVVDMGIPEYDPITAPFKQSPIRHWLGCQQPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M3BSH3</accession>
    <name>M3BSH3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_151894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF09043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757164.1">
        <property type="nucleotide sequence ID" value="XM_016907109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BSH3"/>
    <dbReference type="GeneID" id="27904246"/>
    <dbReference type="eggNOG" id="ENOG502SFV6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_748073_0_0_1"/>
    <dbReference type="OMA" id="ANEAFAW"/>
    <dbReference type="OrthoDB" id="4149149at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="6"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="425" mass="47975" checksum="945DB091C12AE44F" modified="2013-05-01" version="1">MILLGASNGMSDGGHANGVAMEDHQEQRQAEDKRETNEEIVGERPKKRVKLSGRDYAAFASREMDDIETALEVDHMILDYLLYQAISACLDRNNVSICLAQADQFLRLFQGRYPAYRPDQELHFRQLLLQLVTLVTQRYVRCPATPAKSSLQSLRDSNQTRARTWIGDASRLPTVDANTKPFDSALPVTAEELEENRAHVLRSIDIPPEDHVYEDAFYGTSECVSLLDLLPLFMRISGACYTMFSCPPTDTWMRLAAAWMLQACLEQYLIWGASGSDAIDEAFAWGPKRPEDVQEEGEEMTGEAPKIHDRRRDENPFCLDMDGEDAELWKDIRTRALETILSAEDQYWKDLVSHLAAVSERHPLAKTDKEIVCFLKSLAECIPEPVLVQLQKGQLRGMSKEETSAFIRQCGIDIAELFASVDAHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M3BTD0</accession>
    <name>M3BTD0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_119654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF09915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758036.1">
        <property type="nucleotide sequence ID" value="XM_016901532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BTD0"/>
    <dbReference type="GeneID" id="27898669"/>
    <dbReference type="HOGENOM" id="CLU_2307830_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="100" mass="10780" checksum="A0575B42B1F7D6E8" modified="2013-05-01" version="1">MFDDAQQDLDEDLGQDLGEDLAVASKGWTDPVPGARLCSDTALVSILDVQDRSAAVPNLWLSRTSPSCQRAEPASSDEKLSGVPQPQTCGIRRRLEKPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M3BUH8</accession>
    <name>M3BUH8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar protein sorting-associated protein 35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_150040</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a role in vesicular protein sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the VPS35 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF10989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759110.1">
        <property type="nucleotide sequence ID" value="XM_016905928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BUH8"/>
    <dbReference type="STRING" id="692275.M3BUH8"/>
    <dbReference type="GeneID" id="27903065"/>
    <dbReference type="eggNOG" id="KOG1107">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005836_0_0_1"/>
    <dbReference type="OMA" id="YIRSREY"/>
    <dbReference type="OrthoDB" id="10258141at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030906">
        <property type="term" value="C:retromer, cargo-selective complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.660:FF:000002">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.660">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 35, helical subcomplex Vps35-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005378">
        <property type="entry name" value="Vps35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042491">
        <property type="entry name" value="Vps35_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11099:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11099">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03635">
        <property type="entry name" value="Vps35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009375">
        <property type="entry name" value="Retromer_Vps35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="330"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="330"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="376"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF10989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="891" mass="100109" checksum="8DB5B986455C80AE" modified="2013-05-01" version="1">MSSPPPAEDQARLLEDALQVVRQQTLQMRRCLETPGKLMDALKCSSTLVSELRTSSLGPKQYYELYMSVFDALRHLSVYLRDSHPVNHLADLYELVQYAGNIVPRLYLMITVGTVYMGIEDAPVKEIMKDMMEMSRGVQHPVRGLFLRYYLSGQARDHLPEGESAEGPEGNLQDSISFILTNFVEMNKLWVRLQHQGHSRERDQRTKERQELQLLVGSNLVRLSQLVDLESYKNVILQPLLEQVVQCRDVLAQEYLLEVITQVFPDEFHLHTLDQLLAATARLNPHVNVKAIVIGLMDRLSAFAQREAEPKTDEERQKLEDESVSKLLEKLNMSKDDEPEAETKENGHSGDDASPRPSEDTAVASTAESDAPTEGTAVNESETSQANGKTKGIPENVKLFDVFYEQVIHLVTVQRLPIQDITALLTSLINLATTIYPDRLDYVDQVLHYATKEVARYQNSADLHSQSSQHNILNLLLGPVKTYFSLFTALALPNYIPLFLQQPYPTRRNVAGEVVRSLLRNDTKITNMAHLESVLSILSVLVKEGAQSASGYPGGPIRRAVVETEETVEEQGWLARIVHLIKGPDNVAQFRLLQKTRQAFQEGGERTKYTTPAIITQSLKLARNFKRREHLSTDDYAVQSSALYKFMHTALSSLYTRVSASGVPDLVLRLFVSCGQVACQCENEDVAYEFFAQAFTVYEESISDSRSQFQAICIIAGALCGCSDKFSRENYDTLITKAALHGSKLLKKPDQCRAVYLASHLWWAVESAEGGQEAATEGGKETYRDGKRVLECLQRALRVADACMDTAVSVELFVEILNRYVYYFDQENDAVTTKYLNGLIELIHSNLNTTDGASGLENPRKHFQRTLDYIESREYDGVEVKSKSSSLGGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M3BUU2</accession>
    <name>M3BUU2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">40S ribosomal protein Rps16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_88362</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759230.1">
        <property type="nucleotide sequence ID" value="XM_016910472.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BUU2"/>
    <dbReference type="STRING" id="692275.M3BUU2"/>
    <dbReference type="GeneID" id="27907609"/>
    <dbReference type="eggNOG" id="KOG1753">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046483_4_0_1"/>
    <dbReference type="OMA" id="WPIEMAR"/>
    <dbReference type="OrthoDB" id="426865at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000007">
        <property type="entry name" value="40S ribosomal protein S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_uS9_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001749">
        <property type="entry name" value="PRK00474.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF16">
        <property type="entry name" value="RIBOSOMAL PROTEIN S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF11109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="143" mass="16050" checksum="4DEB748DB0F2B224" modified="2013-05-01" version="1" fragment="single">MSAVQSVQCFGKKKTATAVAHTKQGKGLIKVNGKPLSLVEPQILRFKVYEPLLILGLDKFADVDIRVRVRGGGHTSQVYAIRQAIAKSIIAYYQKYIDEHSKNQLKQALVAYDRTLLVADNRRCEPKKFGGPGARARYQKSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M3BVG6</accession>
    <name>M3BVG6_SPHMS</name>
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        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_150283</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759435.1">
        <property type="nucleotide sequence ID" value="XM_016906065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BVG6"/>
    <dbReference type="STRING" id="692275.M3BVG6"/>
    <dbReference type="GeneID" id="27903202"/>
    <dbReference type="eggNOG" id="KOG0417">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030988_13_3_1"/>
    <dbReference type="OMA" id="ADLHTWH"/>
    <dbReference type="OrthoDB" id="9978460at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000060">
        <property type="entry name" value="Ubiquitin conjugating enzyme (UbcB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="6">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF11314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="151" mass="17141" checksum="84D10BC2BC1DC769" modified="2013-05-01" version="1">MANKRIMKEFQEITGNPPTGCTVGLQKEDDMNVWDVHMEGPSDSLYAGGRFHIVITLPKEYPFKPPTLSFRTKIYHPNVSNDERGAMCLGMLKSEEWKPPNKIKEVLSLVRATLSEPQPDDAVEPSIADNFKNNNADFQKQAKEWVKKYAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M3BVV8</accession>
    <name>M3BVV8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">3HCDH_N-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_150392</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759585.1">
        <property type="nucleotide sequence ID" value="XM_016906143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BVV8"/>
    <dbReference type="STRING" id="692275.M3BVV8"/>
    <dbReference type="GeneID" id="27903280"/>
    <dbReference type="eggNOG" id="KOG2304">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_2_0_1"/>
    <dbReference type="OMA" id="MAHPMGP"/>
    <dbReference type="OrthoDB" id="5958943at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000009">
        <property type="entry name" value="Fatty oxidation complex, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006180">
        <property type="entry name" value="3-OHacyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075:SF5">
        <property type="entry name" value="3-HYDROXYBUTYRYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00067">
        <property type="entry name" value="3HCDH"/>
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    <keyword evidence="5" id="KW-0520">NAD</keyword>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="7">
        <location>
            <begin position="53"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="6">
        <location>
            <begin position="241"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="57"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="4">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF11464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="337" mass="35600" checksum="9C4F50EF6490D51E" modified="2013-05-01" version="1">MIMMLAQRLPVAPHAWHRFMAPTCSRVRCFSGTSAALSTGTGSSTEAATVNRLGVVGAGQMGLGIALVAARAAQVPVTLVDTSQASLDKGLAFADKLLAKDVSKQKISREDADAVRGRITATTKMDTLSNVDMVIEAVPEVVQLKTSIFAELAATCPAHAILATNTSSISITRIAAATTKDPTDLSASSRVISTHFMNPVPVQKGVEIISGLQTSPSTLATALEFCRRMGKVPSTSADSPGFLANRILMPYINEAIICLETGVGDEAGIDSIMKNGTNVPMGPLQLADFIGLDTCLSIMEVLHKELGDSKYRPAVRLRLMVDAGWLGKKSGKGFYTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>M3BWA3</accession>
    <name>M3BWA3_SPHMS</name>
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        <submittedName>
            <fullName evidence="6">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_165063</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EMF11594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_016908150.1"/>
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    <dbReference type="HOGENOM" id="CLU_000022_60_0_1"/>
    <dbReference type="OMA" id="CTGVQKS"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="4"/>
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        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
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    </dbReference>
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        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
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        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
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        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
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        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
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        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
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        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
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        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003417">
        <property type="entry name" value="PRK04813.1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF1">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="571"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="1670"/>
            <end position="1746"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="3229"/>
            <end position="3305"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="4331"/>
            <end position="4407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1656"/>
            <end position="1676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="4311"/>
            <end position="4334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="4829"/>
            <end position="4867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="4884"/>
            <end position="4903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="4311"/>
            <end position="4331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="4848"/>
            <end position="4862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF11594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="4947" mass="547203" checksum="9932984E4FAC628E" modified="2013-05-01" version="1">[encoded data, 4947 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M3BWF9</accession>
    <name>M3BWF9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glycosyltransferase family 31 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_20468</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760507.1">
        <property type="nucleotide sequence ID" value="XM_016908330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BWF9"/>
    <dbReference type="STRING" id="692275.M3BWF9"/>
    <dbReference type="GeneID" id="27905467"/>
    <dbReference type="eggNOG" id="KOG2246">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022549_3_1_1"/>
    <dbReference type="OMA" id="KEPPNWD"/>
    <dbReference type="OrthoDB" id="414175at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026050">
        <property type="entry name" value="C1GALT1/C1GALT1_chp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033:SF47">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033">
        <property type="entry name" value="BETA1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF12386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="397" mass="46401" checksum="5E9003C8C304DD73" modified="2013-05-01" version="1" fragment="single">CMHLPGADRVMVMLKTGATELYQKLPAHFITTFKCVPNFMVFSDLNQSFADVPIYDAIAPVSKKIRQEHEDFKLYRDIEKWQREGQDMSKLQGDNGWNLDKWKFMPMFHQVFETASDDIDWFVMMEADTSLSWLNLLLWLQTMDPKQPYYLGAQNVIGQTEFGHGGSGIVVSRKAADVLEAARYNAGKEVYDQQWEEEIAKSCCGDEIIARAFHAVDIPLTHAWPLIQGETISTVDFTDHHWCTPPLTWHHVNPIQVDSYWQFQLDWAHEHGWNKPYLYRDVFERFLAQHVSVNRTSWNNLSKDKKFVAPALATDEDPDFYLLEDYQQRAIQSEELCAEACMREGEGECIQWMYTPGRCHLGKDIRFGQSDEREEEHWNCGWIQDRIAQFKKRHKSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M3BY23</accession>
    <name>M3BY23_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_43946</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761082.1">
        <property type="nucleotide sequence ID" value="XM_016908908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BY23"/>
    <dbReference type="STRING" id="692275.M3BY23"/>
    <dbReference type="GeneID" id="27906045"/>
    <dbReference type="eggNOG" id="ENOG502QVCU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022730_0_1_1"/>
    <dbReference type="OMA" id="LWMDQLD"/>
    <dbReference type="OrthoDB" id="429143at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF279">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="2">
        <location>
            <begin position="38"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF12961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="505" mass="55875" checksum="5F0E1E3EF5B96F5A" modified="2013-05-01" version="1">MATTPCLPVPNATIPFWRTDLDPLDSHRSTEELPSHCDILVIGAGYAGASTVHHILKQQTSPLKILLLEAREACSGASGRNGGHIKPDMYYNILKYSHQYTPSQAASFARFEAQNVLAVKNLVEEEGIDCDFVLTRAVDVYLDEEHSRATLENFGKLKELGKAELGEVEVLEGREAEEFSKIHAAKSCFSYPAAHLHPYKLVLHLLRKAIVQGGVNLQTHTPVTSISDTRNHHHDGGKNYSYWTITTPRGLVRARKVIFCTNAYTGGIAPMFRGKIIPVKGVCCRILNSPPNTNKSQQQLPTNTYSLRHARSLYDYLIPRAQDNPPSIILGGAKPVFWHHQQQEQQQSSPPPPSSPPPPSFPIWYNNPNDNTLFPPPYSSQIQAYFHEFLPKHFISSSSSSSSSSSSSSSSFSSSSIDKIWSGIMGWSTDSMPWIGAIPIPNLRGQGQFILAGFSGHGMPVIYLAAEAVARMVLDEKNFEEMGLPGVFEVTRERLEREGNDILGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M3BZX8</accession>
    <name>M3BZX8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_163290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761742.1">
        <property type="nucleotide sequence ID" value="XM_016908045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BZX8"/>
    <dbReference type="GeneID" id="27905182"/>
    <dbReference type="eggNOG" id="ENOG502T9CG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1156363_0_0_1"/>
    <dbReference type="OMA" id="ACETCLN"/>
    <dbReference type="OrthoDB" id="3884218at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF13621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="287" mass="31491" checksum="A1A7523AE4B1A26E" modified="2013-05-01" version="1">MTMALPRSSPVVGSRPAYLDGLYRDTHNTSSPSTSTSTSTSSYRDAHYPLHSHSSSFSTISTASSYSLRSPPSEKCNSDTLSIRSKKSLSFLSSPKKRFGYILQRHHRHTFPQTSDELQRSASVSSIYSQPPSSSSPSTPILEEKEDEEKKEEAVEEETFVAPPTTTRPPRPTLPRLQTTFAPPNFGPPAHVLAYERKALPAIPRTQKAGAPVRHERLRQASRSQPPPATRRYAPAYEGNHHVPVPTDLGCLKCYYFVARNCNGYVLGGNSGDACDTCLSAGFFGTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M3C126</accession>
    <name>M3C126_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_124302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF13991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762112.1">
        <property type="nucleotide sequence ID" value="XM_016901905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C126"/>
    <dbReference type="GeneID" id="27899042"/>
    <dbReference type="HOGENOM" id="CLU_2151870_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF13991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="112" mass="12112" checksum="080AE83E5F1DDF0A" modified="2013-05-01" version="1" fragment="single">MAVLAAYGVEKSEQQVASALGKLTKLSWYVCNPLILLPAAVYRCVPGIDGELPLTNMLSYRITMPVDPSQKQFETPRIQPVQGSGHSTLNAAAHSANFSKEKKRDQNPAGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M3C1C2</accession>
    <name>M3C1C2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_115394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762222.1">
        <property type="nucleotide sequence ID" value="XM_016901156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C1C2"/>
    <dbReference type="GeneID" id="27898293"/>
    <dbReference type="HOGENOM" id="CLU_2293463_0_0_1"/>
    <dbReference type="OrthoDB" id="1029639at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF14101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="101" mass="11388" checksum="5DAE2521ED41DEF4" modified="2013-05-01" version="1">MEGAADREQGLGRRESLKAKFNFRGHQMKEKTKDVFRRGSNSSKQSLQSLRSFRGDSIFTINNDMSLIEDGPEWGPATIPRTPNRASTITTGSTSKIRREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M3C1D6</accession>
    <name>M3C1D6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GTP-binding nuclear protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_147937</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the small GTPase superfamily. Ran family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762237.1">
        <property type="nucleotide sequence ID" value="XM_016904607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C1D6"/>
    <dbReference type="STRING" id="692275.M3C1D6"/>
    <dbReference type="GeneID" id="27901744"/>
    <dbReference type="eggNOG" id="KOG0096">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_13_0_1"/>
    <dbReference type="OMA" id="FNAWDTA"/>
    <dbReference type="OrthoDB" id="48625at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00877">
        <property type="entry name" value="Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000131">
        <property type="entry name" value="GTP-binding nuclear protein Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002041">
        <property type="entry name" value="Ran_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071:SF0">
        <property type="entry name" value="GTP-BINDING NUCLEAR PROTEIN RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071">
        <property type="entry name" value="RAN GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00627">
        <property type="entry name" value="GTPRANTC4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51418">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF14116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="214" mass="23938" checksum="DBD9225A4B467857" modified="2013-05-01" version="1">MAEGTPTFKLVLVGDGGTGKTTFVKRHLTGEFEKKYIATLGVEVHPLGFTTNLGQIQFDVWDTAGQEKFGGLRDGYYINGQCGIIMFDVTSRITYKNVPNWHRDLVRVCENIPIVLTGNKVDVKERKVKAKTITFHRKKNLQYYDISAKSNYNFEKPFLWLARKLVGNQGLEFVAAPALAPPEVQVDQAAMEAAQKEMADAANMPLPDEEDPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M3C5F9</accession>
    <name>M3C5F9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_147368</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763617.1">
        <property type="nucleotide sequence ID" value="XM_016904252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C5F9"/>
    <dbReference type="STRING" id="692275.M3C5F9"/>
    <dbReference type="GeneID" id="27901389"/>
    <dbReference type="eggNOG" id="KOG2126">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004298_1_0_1"/>
    <dbReference type="OMA" id="YPSFDIF"/>
    <dbReference type="OrthoDB" id="272139at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16023">
        <property type="entry name" value="GPI_EPT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037675">
        <property type="entry name" value="PIG-O_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039524">
        <property type="entry name" value="PIGO/GPI13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071:SF1">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="487"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="523"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="553"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="584"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="684"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="715"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="755"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="927"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="962"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1003"/>
            <end position="1028"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF15496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1039" mass="114388" checksum="F3BBCA430C3D3D57" modified="2013-05-01" version="1">MANAPAAMSKQAATRDIKAQNKKRNLEFRAQHGLVVAFFLLILIFHALGIYLFLNGFLLSRLVLQHRSDCAVPPIALSEHPKDFVAGSYGQGCWHPKSFNKAVVIIVDALRYDFTVPFHPTPGNDHPQHFHDALPVLYETSVNEPQNAFLRPFIADPPTTTLQRLKGLTTGTLPVLIDAGSNFAGTAIDEDNIVEMLYKAGKKVVHLGDDTWHSLFPGYFEPNLTRAYDSFNVWDLHTVDNGVTEHLFPLLEPSMNGRWDVIFGHYLGVDHAGHRYGPDHPAMNEKLKQMNDVIRRIVSTLDDDTLLVVMGDHGMDVKGDHGGESDDEVQAALWMYSKRGIFGRSDRSSMAPPLTAQQRPVAQIDLVPTMSLLLGLPVPFNNLGQPIEEAFHKSPVLTEPNYDNLAQVARLTAAQIHRYQAEYAKARGLGNSTASSTEQLWQVANQAWSTARSGGASSSQKDAWAAFSAYQTENLRICKSLWARFDLVSMTMGIIALVGTFLMVLVYAQGILRGDRAAITPPLFIWGLGGTLVGAMIGAVAGQLTKEHEVQSIAFGAALGGVTMTMAMFWPARELLSVPRPTTFWGWLCMLTTILLCGGFAANSFTIWEDEQLLFILTTFALAMLGSSLGQGDPDDRWLGATNALSFLIATRLTSLSRLCREEQMPFCRSSYYASATSSTSSKWQLAIPLAVALFLPSAITHFYKRSANYHGSAVIWIGIALRLGLVMVATFWAIDAADDGDWFPQYSGSILKTVRTYLAQSVLALTFAAGYATYIFASPMLMVKHEEADRVVAKSETLSETDPTSPVLTTVGASGPARRPKLMIYGYSNSHGTRYFLLPCAWILTLLLFQKPMGQGALAFCMIQILNVLEIIDANNLRRSPLGPTVLALLGSFHFFKTGHQAALVTIQWDTAFIPLKTIVYPWTPIFVILNTFGPQILCAIAVPAIVMWKVPPRHTGVLGRVAGCMATHILFYAAIAVATVIEAAWLRRHLMLYRVFMPRMLLSVMTLLLIEFVGACIALVGVRWSIVSVGEVFGWPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M3C6D9</accession>
    <name>M3C6D9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_61100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763947.1">
        <property type="nucleotide sequence ID" value="XM_016909550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C6D9"/>
    <dbReference type="STRING" id="692275.M3C6D9"/>
    <dbReference type="GeneID" id="27906687"/>
    <dbReference type="HOGENOM" id="CLU_2198643_0_0_1"/>
    <dbReference type="OrthoDB" id="2320332at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015075">
        <property type="entry name" value="AtaL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08982">
        <property type="entry name" value="AtaL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF15826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="108" mass="12537" checksum="46AC22196C6E93A4" modified="2013-05-01" version="1">MIRGEGSGRRGKGEEVKEFAMLKRPVMIEFEFPRNGSFITNILAPGSGEDKGQMYLTSMYEWHCPEVEEGSEEYREKQSEYFQMARKIVAHTVEEVRKMKKEGLLKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M3C9I2</accession>
    <name>M3C9I2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_136628</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756596.1">
        <property type="nucleotide sequence ID" value="XM_016902787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C9I2"/>
    <dbReference type="GeneID" id="27899924"/>
    <dbReference type="HOGENOM" id="CLU_1210447_0_0_1"/>
    <dbReference type="OrthoDB" id="3537171at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF08475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="229" mass="26526" checksum="88258D2D0B02BDAE" modified="2013-05-01" version="1">MHCTYRHPDRLYTSEVFQGAVLRFPDDSLVHRFINERVHYRNEADDQKPYRILDPYWDRRKALPSTGPYDHPIVVLSRPREDPDHIVFAVMTTTLRKADRPRGIFTRERDYVAVYPSSPITKYFPGSHGLSGAVLEFCGRRNTRKSDVCINPIFCTKWRNCTRWKDDSGTVGGWALNPESVTAVLDHAKARLRYSPDVNQFRPHYGIKSAAASQLQRKNIAIRPKVLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M3C9T6</accession>
    <name>M3C9T6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">Protein transport protein SEC23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">SEPMUDRAFT_152231</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15 16">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 16">Cytoplasmic vesicle</location>
            <location evidence="1 16">COPII-coated vesicle membrane</location>
            <topology evidence="1 16">Peripheral membrane protein</topology>
            <orientation evidence="1 16">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 16">Endoplasmic reticulum membrane</location>
            <topology evidence="2 16">Peripheral membrane protein</topology>
            <orientation evidence="2 16">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Golgi apparatus membrane</location>
            <topology evidence="16">Peripheral membrane protein</topology>
            <orientation evidence="16">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the SEC23/SEC24 family. SEC23 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756731.1">
        <property type="nucleotide sequence ID" value="XM_016907316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C9T6"/>
    <dbReference type="STRING" id="692275.M3C9T6"/>
    <dbReference type="GeneID" id="27904453"/>
    <dbReference type="eggNOG" id="KOG1986">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008658_3_0_1"/>
    <dbReference type="OMA" id="FPPHYAE"/>
    <dbReference type="OrthoDB" id="10256289at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01478">
        <property type="entry name" value="Sec23-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11287">
        <property type="entry name" value="Sec23_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.730:FF:000001">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.380:FF:000001">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000006">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000008">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037364">
        <property type="entry name" value="Sec23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037550">
        <property type="entry name" value="Sec23_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141:SF0">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14 16" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8 16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 16" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="12 16" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 16" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0813">Transport</keyword>
    <keyword evidence="9 16" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="18">
        <location>
            <begin position="61"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="19">
        <location>
            <begin position="128"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="21">
        <location>
            <begin position="412"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="20">
        <location>
            <begin position="531"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="17">
        <location>
            <begin position="645"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU365030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EMF08610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="780" mass="86399" checksum="2969ADB2A205CC5B" modified="2013-05-01" version="1">MDYEALKDQWSEIEDRDGIRLSWNTFPSSRMEASRLVVPIGALYTPLKEKDDGTPLLQYEPVTCKPPCRAVLNPFCQVDMRARIWICPFCLQRNNLPPHYKDISENQIPPELHPGSTTIEYRLARPAPMPPIFVFVIDTCQEEDSLKALRDSIITCLSYLPPHALVGLITYGTMAQVHELGYTECAKSYVFRGNKDYGAKQVQEMLGLSMAAGARPGMQPQPQPGRPAVAPPVGGAQARFLLPVQQCEFQLTNVLESLQKDPWPVANDKRAIRCTGVALSVATGLLETSFQNSGARIMLFTGGPATEGPGMVVGPELKEQIRSHHDIDRDNIKYYKKALKFYDTLAKRVAHNGHVVDIFAGCLDQVGLLEMKGLPNSTGGHIILTDSFTASMFKSSFLKIFDADESGTLAMGFNASMEVLTTKELKVTGLIGHAVSLNKKSSSVGETECGIGNTCSWKMCGIDPSASYGVYFEIASQGGPAAPMQQGPQKGLIQFLTYYQHSGGQYHLRVTTVGRNMSGPSGDPAIAQSFDQEAAAVLMSRIAVFKAEVDDGPDVLRWVDRMLIRLCSRFAEYRKDDPSSFRLEKNFTLYPQFMFHLRRSQFLQVFNNSPDETAFYRHVLNHEDVSNSLVMIQPTLDSYTFDQEGAVPVLLDSSSIQPTTILLLDTFFHILIFHGETMAEWRKAGYQDMEGYENFSELLDAPKQDAKELISDRFPLPRFIVCDAGGSQARFLLAKLNPSTTHTSSSYGGVSQTAQTIFTDDVSLQTFMDHLMKLAVSGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M3CAY0</accession>
    <name>M3CAY0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ubiquitin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_73336</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757101.1">
        <property type="nucleotide sequence ID" value="XM_016910022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CAY0"/>
    <dbReference type="STRING" id="692275.M3CAY0"/>
    <dbReference type="GeneID" id="27907159"/>
    <dbReference type="eggNOG" id="KOG0003">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010412_4_1_1"/>
    <dbReference type="OMA" id="EPEPTMQ"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51039">
        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="6">
        <location>
            <begin position="25"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="AN1-type" evidence="7">
        <location>
            <begin position="102"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF08980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="172" mass="19059" checksum="F53CC610825EC4B7" modified="2013-05-01" version="1">MRSNSISSISSTSSRAPSAEPEPTMQIFVKDIAGETFPLTIPESTTVSTLRSLLALRTNVPESSMRIVHAGKHLSQSNSTLSSYRVASESTLHMVLPIRGGGPKKIRCAFKDCKDAIVRITGDCTFCHKSYCNKHRMLESHSCSGLEDCKKEEKERNREKLESEMTRPIKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M3CEE5</accession>
    <name>M3CEE5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Paf1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_150363</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PAF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759542.1">
        <property type="nucleotide sequence ID" value="XM_016906119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CEE5"/>
    <dbReference type="STRING" id="692275.M3CEE5"/>
    <dbReference type="GeneID" id="27903256"/>
    <dbReference type="eggNOG" id="KOG2478">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021991_1_1_1"/>
    <dbReference type="OMA" id="GAYYYPI"/>
    <dbReference type="OrthoDB" id="10260285at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007133">
        <property type="entry name" value="RNA_pol_II-assoc_Paf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23188">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23188:SF12">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03985">
        <property type="entry name" value="Paf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF11421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="436" mass="48806" checksum="A1F907D82BFEF9A9" modified="2013-05-01" version="1">MSSGRPGEKVVHQDYIARIRYSNALPPPPNPPKLLDIPGTGLSGGQYTSAGYSSRLARDQPLNIEADAELGMPIDLIGIPGIFEGKEEAISFRPNAKELLHPADRALLRPLGQLGKAGASQGSVSFLRRTEYSSSQQAQHFSSSTSKDLLRMRNDNKRRKASMNKDDPINIMRHIVKGFDIAYPQDAYKGEDNTENLRGAEVTDAELKAWSRPKHPTNPDLKLLDSYPILPDADAIPSLGFYMVMKYVSNPSDIRDTYDHRLDTALMKPVSDERANEEFAEKLREWQESDMSKPEPIQEYDYDYYLPIDRQAVRGIKRKLDVGAADKDDDALYTDDNGDGVPCFKYKRIRTYETYKQHGDSRNMYNDAVAIALHDADGESGSARLQKGAYFYPVVQTTALRPKRQTAQSQYGTEPKVDELNVVIGDPKVVAVAEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M3CGV1</accession>
    <name>M3CGV1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Clr5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_149542</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF13043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761164.1">
        <property type="nucleotide sequence ID" value="XM_016905619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CGV1"/>
    <dbReference type="STRING" id="692275.M3CGV1"/>
    <dbReference type="GeneID" id="27902756"/>
    <dbReference type="eggNOG" id="ENOG502R9I7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_874839_0_0_1"/>
    <dbReference type="OrthoDB" id="5392716at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025676">
        <property type="entry name" value="Clr5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46177">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46177:SF1">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14420">
        <property type="entry name" value="Clr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clr5" evidence="2">
        <location>
            <begin position="10"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF13043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="318" mass="36323" checksum="96D45A18AB84F0E5" modified="2013-05-01" version="1">MPGGRPPLCLDEHREFITTSIQVLGLTREEVVDELSKSHGLAVSRGTLRRRLLDWGIRTQRANFSDSPALRVRLQHYFHNSGLTDLEISETLTRDEGFDISPKRVAKCRKEMGLYKRVDADKRGVAERTVEELLKKELEENEAVRELGQKALYKHLRSKYNVTGRDRIFTIAKRLDPEGPERRSRAQRKGARRSGLRKEREAKAAEEEARRQQQQQPGGEHLIEQQQHEQSRPEYVPLDPTMYDSNYGAYGQQPGVPNGDAAITNHLHPHHRVPQEEHSQVGEGSTNSRGQLQCYYPSSITTGVNLEEDYHYARGLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M3CH44</accession>
    <name>M3CH44_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Annexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_148511</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="domain">
        <text evidence="6">A pair of annexin repeats may form one binding site for calcium and phospholipid.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the annexin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761254.1">
        <property type="nucleotide sequence ID" value="XM_016904968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CH44"/>
    <dbReference type="STRING" id="692275.M3CH44"/>
    <dbReference type="GeneID" id="27902105"/>
    <dbReference type="eggNOG" id="KOG0819">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025300_4_0_1"/>
    <dbReference type="OMA" id="VRGPLMQ"/>
    <dbReference type="OrthoDB" id="37886at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000002">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.10">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001464">
        <property type="entry name" value="Annexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018502">
        <property type="entry name" value="Annexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018252">
        <property type="entry name" value="Annexin_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009117">
        <property type="entry name" value="ANX14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502:SF102">
        <property type="entry name" value="ANNEXIN B11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00191">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00196">
        <property type="entry name" value="ANNEXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01813">
        <property type="entry name" value="ANNEXINFUNGI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00335">
        <property type="entry name" value="ANX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00223">
        <property type="entry name" value="ANNEXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51897">
        <property type="entry name" value="ANNEXIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0041">Annexin</keyword>
    <keyword evidence="3 6" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 6" id="KW-0111">Calcium/phospholipid-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="WW" evidence="8">
        <location>
            <begin position="56"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="86"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF13133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="449" mass="49087" checksum="FD2080F548366458" modified="2013-05-01" version="1">MAHYQQSYGAPGGPQPYQQYPPGGGYYQQPMNHGFGQQQGFGGAPPGPPPPQGGGPPLPPGWTSQFDPSSQRPYYISPTGASQWDPPAPGFGGPPPGPPPPAQGGFGQSPYPQQQPGGFPQQQQYGGPAALPSPGYDLRQRSHQDVTRAADDLRASMKGFGTNETLLIKVMASLGPLEIAAVKQVYQQRHKRDLLKDVHSETSGYFREGLEAMIRGPLEQDCWVIHESIKGLGTKESALNDVLLARSNADMNAIKQHYQHMYRKSLESDVKGDLSMKTERMFDMVMSARRAEESAPVIPQQTEQDIKDMYSATEGKTGTDQMTVCSILTSRSNGQIRAIVQAYQAKYHRSLQSVIKAEFSGHMQDALLFIIGAAADPAKNDADLLEASMAGLGTKDQALVRRVVMIHWDKQRLHQCKAAYKHFYKKDLAARIASETSGDYKKLMVACVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>M3CJL8</accession>
    <name>M3CJL8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_115296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016901147.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="27898284"/>
    <dbReference type="HOGENOM" id="CLU_1361170_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF14003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="201" mass="22077" checksum="987CF56C905B9294" modified="2013-05-01" version="1">MCNFTTTYHTICKHYSTRQYTYCPLAESQNALATNSPQSCHNTTDMGLETDFTVSCIMCQRTRARTLFFTGIPPQPEPQAITYGIVASRSVEKGIPSVCVTSWVDTGSTGSGSGSGRTSPSMSRCDSNMSLASLSPSLASISSSSSQQNSQGSYRGWSFKEGKFGNAHWRSYQDDEQAALIQQKRQAKERTALKSCHEDYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M3CJQ5</accession>
    <name>M3CJQ5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_106431</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762174.1">
        <property type="nucleotide sequence ID" value="XM_016900632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CJQ5"/>
    <dbReference type="GeneID" id="27897769"/>
    <dbReference type="HOGENOM" id="CLU_785656_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF14053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="353" mass="38479" checksum="C09CA44C8AF7980C" modified="2013-05-01" version="1">MRAPSSKCRRTLKIWRKKNANPDVDIGTWDSTAPATWSSNPTAGSISIDEAPTPFPNSYGTSSFLFSPSPSLETPTTTSTHQASISHVTNTCRDCRITAATTTSTSAGTLVSDDASRRQQQQQQHRPQVPLVIAVVTLSCLILVISLVLGWLRCRRRRGKLPQKQEELVEHACLHRASNVDDSSHDSVAGVAHVQEKKNNLAAQTRSTSSSPAGPSLLPDASSSTRRLLSPSDIVLPDRPGKRARGTRDPYPSFSSANTEDCHPAFFILPDDVDDDDDDDDDDDRDARDLPPTPPPKHRMIPPRAPPSSPTLSPRHGRSSGRAEQRPIPETPHVRALHELPSVSSRSDQIESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M3CLJ3</accession>
    <name>M3CLJ3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_132278</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762784.1">
        <property type="nucleotide sequence ID" value="XM_016902485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CLJ3"/>
    <dbReference type="GeneID" id="27899622"/>
    <dbReference type="eggNOG" id="ENOG502SY4G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097983_0_0_1"/>
    <dbReference type="OMA" id="KELEWSY"/>
    <dbReference type="OrthoDB" id="4148767at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF14663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="291" mass="33830" checksum="1751026AC36585B0" modified="2013-05-01" version="1">MGIILSTTRYAPFSLVTGIIGLISFVFTLTTWLRVLWGNFTTAGQATHEVHAYLTNLRTELLEERASIRVMRKQCRKYQRRLEKRYDGGDTLMDIGLDDVSLKTMADTIKRLIKQFQELERPFLAEGSEGIGGYQRHERRSRRRRNESVSPYYEHSAYAAPPPPSPPNPRGSRARSRGDSRRRRRRKGQRDEGDDEDDDEDEDDDADTFWAQRTQYKQFGIVCRYNWVQKKSQCQELFSTLSRVQIRRIARQVGGLSLLAYESGPRLERSEAMLTRIEHRLGNIVGVRRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M3CLM9</accession>
    <name>M3CLM9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Multi protein-bridging factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_148332</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762819.1">
        <property type="nucleotide sequence ID" value="XM_016904856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CLM9"/>
    <dbReference type="STRING" id="692275.M3CLM9"/>
    <dbReference type="GeneID" id="27901993"/>
    <dbReference type="eggNOG" id="KOG3398">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112609_0_0_1"/>
    <dbReference type="OMA" id="GKNKSCK"/>
    <dbReference type="OrthoDB" id="10253401at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013729">
        <property type="entry name" value="MBF1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245:SF15">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1 MULTIPROTEIN BRIDGING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08523">
        <property type="entry name" value="MBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Multiprotein bridging factor 1 N-terminal" evidence="3">
        <location>
            <begin position="3"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF14698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="159" mass="16781" checksum="F1A14A3FE392C1EF" modified="2013-05-01" version="1">MSDDWESTTKIGSKVRGPGTAQREVTIKGKSALNAAQRSGAILATEKKFSTANASGNPEGQRLTKVDRADGPVATKKVPDEVAKALQQARTQLKNQKGTTMTQKDLSSKANVDVAVVAALERVGADFPPMDAVLKIQKAANVRLTGSNIGQPMLGPKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M3CLY1</accession>
    <name>M3CLY1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_148396</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762914.1">
        <property type="nucleotide sequence ID" value="XM_016904898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CLY1"/>
    <dbReference type="STRING" id="692275.M3CLY1"/>
    <dbReference type="GeneID" id="27902035"/>
    <dbReference type="eggNOG" id="KOG3662">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021690_1_0_1"/>
    <dbReference type="OMA" id="GLKEQNH"/>
    <dbReference type="OrthoDB" id="9984693at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033308">
        <property type="entry name" value="PGAP5/Cdc1/Ted1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315">
        <property type="entry name" value="METALLO PHOSPHOESTERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315:SF1">
        <property type="entry name" value="PROTEIN TED1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="487"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF14793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="529" mass="60163" checksum="FC930AC4F5E7228B" modified="2013-05-01" version="1">MSVFFLRVYSALLATAVAGTFYLFFYPTFHQCSFPSSNIDTGQQAPFRLLAFGDPQLEGDTSLPGNGHTELFPSIRRILDSIQQRGFGGSINSISREGRRLLHEDLPTAVRTYHKKLDLWGNDQYLAHIYRTVSRQTDPTHVVVLGDLLGSQWIDDDEFRRRSHRFWQTVFKEGERVPSDITDYKNVPAEELSGNKSWKNRIITVAGNHDIGYAGDIDEDRIRRFEDTYGRVNYEINFKLNDTSTVDDTTAKHLAPELRLIILNSMNLDEPALHQGLQQDSIDFLNQRLYWEIPQSDTAGTILLTHIPLYKEAGICKDGPFFEHFPVRPNEYYSGGIREQNHLTYDLSARILEGIVGPERTRRSIILNGHDHHGCDTYHSRTLIEKPLPVPEPILPREDEDDEAYEARIAKMAPVPLPEPEKWRAQQYRNAAKTIEDKELAGVREITVRSMMGEFGGHAGLLSAWWNAEQQEWQYEYATCAAGVQHIWWAIQVVNVITFGAGVAGVLLFGAGKLSSSSQTTATERKKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M3CND4</accession>
    <name>M3CND4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">nitrilase</fullName>
            <ecNumber evidence="4">3.5.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_147215</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a nitrile + 2 H2O = a carboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:21724"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18379"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="EC" id="3.5.5.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.5.1" evidence="4"/>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763419.1">
        <property type="nucleotide sequence ID" value="XM_016904153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CND4"/>
    <dbReference type="STRING" id="692275.M3CND4"/>
    <dbReference type="GeneID" id="27901290"/>
    <dbReference type="eggNOG" id="KOG0805">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030130_6_0_1"/>
    <dbReference type="OMA" id="WYPYFSF"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000257">
        <property type="term" value="F:nitrilase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07564">
        <property type="entry name" value="nitrilases_CHs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000132">
        <property type="entry name" value="Nitrilase/CN_hydratase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044149">
        <property type="entry name" value="Nitrilases_CHs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044:SF14">
        <property type="entry name" value="ARYLACETONITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044">
        <property type="entry name" value="NITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00920">
        <property type="entry name" value="NITRIL_CHT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00921">
        <property type="entry name" value="NITRIL_CHT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="6">
        <location>
            <begin position="9"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00036406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF15298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="322" mass="35248" checksum="57CEE4AD2DDFE547" modified="2013-05-01" version="1">MGSTTPATVRVAVTQHEPVWLDLQATIDKTVEIIKEAAAEGAKLVTFPECWVPGYPAWIWSRPVDFDLGVKYVQNCLKVQSPEMQRIRDAAAESQINVALGFSERDGDSLYIAQALIDESGELKMTRRKMKPTHMERTVFGDATGGSSCLSKVVDIPEVGRVGGLSCWEHIQPLLKYYTFAQNEQIHVGAWPPLDGFIEGSPGFYSMSIEGCRNASQAYAIESQAFVIHCTTVLTEAGIQAMQTAGAPIMGHSIQGSSCVIGPDGRILSKMDNPNEKLIIADLDLNLITKTKTFADASGHYSRPDLMWLGVDEKTKLVIRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M3CNJ8</accession>
    <name>M3CNJ8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_15784</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763474.1">
        <property type="nucleotide sequence ID" value="XM_016907752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CNJ8"/>
    <dbReference type="STRING" id="692275.M3CNJ8"/>
    <dbReference type="GeneID" id="27904889"/>
    <dbReference type="eggNOG" id="ENOG502SSYK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092550_2_0_1"/>
    <dbReference type="OMA" id="HTNSFRD"/>
    <dbReference type="OrthoDB" id="5427070at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF15353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="95" mass="10780" checksum="E9A987B88F74749D" modified="2013-05-01" version="1" fragment="single">LFLPACIAAALYGTISYIIIPLIRNYRERYSQYLPLDTVNRHTEGLRDRISDLVLRLVIPRRQTVFDASGSRRGSRSGSGDLFSEEEGERMAGFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M3CNY4</accession>
    <name>M3CNY4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_80257</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763609.1">
        <property type="nucleotide sequence ID" value="XM_016910239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CNY4"/>
    <dbReference type="STRING" id="692275.M3CNY4"/>
    <dbReference type="GeneID" id="27907376"/>
    <dbReference type="eggNOG" id="KOG2071">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015606_0_0_1"/>
    <dbReference type="OMA" id="ARSDFAN"/>
    <dbReference type="OrthoDB" id="343582at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16982">
        <property type="entry name" value="CID_Pcf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000016">
        <property type="entry name" value="mRNA cleavage factor complex component Pcf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045154">
        <property type="entry name" value="PCF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054127">
        <property type="entry name" value="Pcf11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047415">
        <property type="entry name" value="Pcf11_CID"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15921:SF3">
        <property type="entry name" value="PRE-MRNA CLEAVAGE COMPLEX 2 PROTEIN PCF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15921">
        <property type="entry name" value="PRE-MRNA CLEAVAGE COMPLEX II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21936">
        <property type="entry name" value="Pcf11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="2">
        <location>
            <begin position="14"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="643"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="190"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="667"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF15488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="678" mass="74073" checksum="E3428560510BF9DE" modified="2013-05-01" version="1">MSSRSPRGSISGGSSAEVAADFEESLKDLQSNNRYEISNLTVIAKENTEHAQAISRVLETHIKTTSPTRKLPALFVLDSIVKNVGTPYTVYLGRNLYNTFMEAYTLVDTATRRHMDAMLKTWKEPVPGSIDPRPVFPRETVQPLENAMIKARAALEKIRQSQVPFQGTATPPQHNGQYARPPVQTPQQFYPGYGVPQQPTPQQQPQQQYAYQPPLANLTNDIENVKRDIDSLIPRFQYQLAATPHDIGLQTQLSALNQLRNLLNIQRVSSVELQQIKQQVSSLAPAVPQFPQQTPQPTPQQWEAPPPPFPPQFPHSTPMFPAATPQHQPSASTPHLSADALNGLQALLASAQPPSTPQLRAAVPGFQNASHSQMNAIQNHTAPAPSQNGAADLIASLTKAGLINPGSNHAPSTTTASPAVTAPPPMDPTAALLKSLNALPQPPSQAGTPSLVPTSLTAQRPNVPISAAALKVFRPELVTSMYDAFPNQCSTCGRRFHATEDGRQKKSLHLDWHFRTNQRIADPNTNRGHHRNWFPDEMDWIRHVEFDPSTTTATAVDTQEASKTQKSPMEQVVRAPAGMTKSTCSICYEDLSSTYSEEHQDWVFANAAYMNKKIVHASCLAEMTKSRPPPSADRGALAAAIASVSAGQRERSATPDSLLGKRKAESVMTSNSSRIKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M3CQ00</accession>
    <name>M3CQ00_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Metacaspase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_139469</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763919.1">
        <property type="nucleotide sequence ID" value="XM_016902905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CQ00"/>
    <dbReference type="GeneID" id="27900042"/>
    <dbReference type="eggNOG" id="KOG1546">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029389_3_0_1"/>
    <dbReference type="OMA" id="NCGAMTW"/>
    <dbReference type="OrthoDB" id="3223806at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12660">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="5">
        <location>
            <begin position="7"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF15798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="310" mass="34681" checksum="D2B04E022A4DB497" modified="2013-05-01" version="1">MNQEPIKKSLLIGINYTGSKHELRGCHSDAENMAEFLRYRGYEKENQVVLRDDLSGPAYPSRDNMLRAMSWLVSKPGTMNFLHYSGHGGQERDDNRSTGYDDTICPVDFERAGQINSATLHQVLVSALPPNSTLFVVLDCCHSGSAVELPYVYRTDDDGKISIMNNVKAGLNLVMEADNLLEGRYGLNSVAAAKQMLGDANNFFQGFRHQHHGPAGLESDNTGRDWSREQKFVTMYSGCRDEETSADAYIAGRNCGAMTWAFLETMKHNRDPTYIQTLQATRANLRGSQYKQVPQLSVGVQMDLDQPLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M3CQW8</accession>
    <name>M3CQW8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SEPMUDRAFT_147741</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the RBR family. RNF14 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="3"/>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF16068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764189.1">
        <property type="nucleotide sequence ID" value="XM_016904495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CQW8"/>
    <dbReference type="STRING" id="692275.M3CQW8"/>
    <dbReference type="GeneID" id="27901632"/>
    <dbReference type="eggNOG" id="KOG1814">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021364_3_0_1"/>
    <dbReference type="OMA" id="PRSWCQG"/>
    <dbReference type="OrthoDB" id="1431934at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20354">
        <property type="entry name" value="Rcat_RBR_RNF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23820">
        <property type="entry name" value="RWD_RNF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000416">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047548">
        <property type="entry name" value="Rcat_RBR_RNF14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RWD" evidence="14">
        <location>
            <begin position="12"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="181"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="185"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="312"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="557"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="566"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="578"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="625"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="648"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMF16068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="666" mass="74894" checksum="8F4C4C42964EFDB1" modified="2013-05-01" version="1">MASVDDEDEREEELGSLTAIYPELVVDQDFTATLSLPVAPAAPLLVRFVPQSGSTPNYALALNKSHVERDVHLSNLPPLELHVVLPNEYPATAPPKVRLTAQYDWLPKEKVAALEAEAAKLWEEYGCCQILFVYIDHLQQAAERAFDLADSADGCLVLPETHESNLVSFDARTKLAIFNAGTYDCGVCLEPRKGCACYKMEKCEHVFCKQCLQDFYNNAIKEGDVAVMRCLDPGCGKDKKRKKKSERTLHPRELLAMGVEEDKVRRYVEMKRKKKLEADKNTVYCPRKWCQGPAKSDKYPLIPADLNAYVDPSSDAESDVDDDNKKTIPTVAADPPKKVNLNNSQPDPTDRLAVCEKCLLAFCKVCYSGWHGNFVRCYPRDPNELSVEEKATYEYIRLHTSPCPYCQAPVQKTMGCNHMSCFNCRTHFCYLCGSWLDGENPYQHFNKGGSPCYQRLWELEEGDEGQGPEDGRGFAGGARGWEQLAIEAARQADEQAAATEAARLQAEEDARGPILHNDHIQQQPLLAQLAHLDIEVNFDDLNDQELNLLGIQRAELAPVPQPQHHPQQRGRGGRRARNPYPRAPANAGRGAAQAVRAHERRQPRPAQGRNRPRAVGVDANAEQQDDVRDRQQQEELERFIELARRDQEDDWDSDGLADDDGEFEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M3CR75</accession>
    <name>M3CR75_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_147808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF16168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764289.1">
        <property type="nucleotide sequence ID" value="XM_016904537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CR75"/>
    <dbReference type="STRING" id="692275.M3CR75"/>
    <dbReference type="GeneID" id="27901674"/>
    <dbReference type="eggNOG" id="ENOG502SNAB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010595_9_1_1"/>
    <dbReference type="OMA" id="NITLRQW"/>
    <dbReference type="OrthoDB" id="417697at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF96">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF16168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="314" mass="35838" checksum="4B2215763AD1BD4E" modified="2013-05-01" version="1">MALQLEDHAKRNAGDQTPPSRPDSAIDVHDDYVLTRDAAASARLNLSHYIWQSSYGYNLHPRIQDAIRGKENLHIADIGTGTGIWLLDLAQQLPASTRLDAIDISFGQLPPREWLPKNVTLRLADVFRPPTDDLVEKYDVIHIRHFVCVVKENDPTPLLKNLLRMLKPGGWLQWDEWDVLNRHFVKASPSHSHSSIDKLEEEFANMRRYTPRPEWTARLDDYFLMQNVQQVALEKRLSSIGHVSFMHDLSLLVFQELIDGAELKGLIDEEKVLYLRRLLGGATRESRMGAAWNLTRCMAVGQKARSESMGAFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M3CV91</accession>
    <name>M3CV91_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RDRP C-terminal head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_152361</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF08067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756188.1">
        <property type="nucleotide sequence ID" value="XM_016907398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CV91"/>
    <dbReference type="STRING" id="692275.M3CV91"/>
    <dbReference type="GeneID" id="27904535"/>
    <dbReference type="eggNOG" id="KOG0988">
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        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
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        </location>
    </feature>
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            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF08067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="396" mass="44058" checksum="2FB9A9069602FB9A" modified="2013-05-01" version="1">MPADLRIQRWPHWSEPRNKAKSKVYTSHRVLGKLYDEVKKEPFHAAWDMPFDERILTALEPSHQMLNDAKEIKALYDEAIRRIMAQHGIKTEFEVFTTFVLEHHQEIGDYKFAETMGEMTANLKQQHQELCYNRAGTNAADRDWDKMKPFIVAMYKVTATEIEEALKETKTMRAKGGRDTPIRALDFKSMPLMSFPWIFAAELGRIATKGHGAGVVAMPKPTLPKSTTAAKRNWSLLPDGWKPAPLLEVDTSKGVVREGDLFDLFGSGPAVDDGDNKTKKTVVVVPNIPDMAVEMPQPARSVSQAVSPPLSPPMSPLRADSPTVPSRPATSTHTAETSSVSTISPIGASDEVEFEFDEGEVEFDVTKEEGEIAFDLKPSAFDKFAASHGFGDDEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M3CVD9</accession>
    <name>M3CVD9_SPHMS</name>
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        <recommendedName>
            <fullName evidence="3">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_145407</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_016903102.1"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
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        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
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    </feature>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMF08117.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>M3CX04</accession>
    <name>M3CX04_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_121425</name>
    </gene>
    <organism evidence="1 2">
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        <name type="synonym">Septoria musiva</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
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                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="GeneID" id="27898824"/>
    <dbReference type="HOGENOM" id="CLU_2759426_0_0_1"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF08652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="70" mass="7864" checksum="9F4FB1027D098FDB" modified="2013-05-01" version="1">MPPKRAIAAKAPEKPVLERDPRRGRAAARAYNIYLRYIEAIEHMFKVVDANGVAERAYNGVIAPGRKKKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M3CYW2</accession>
    <name>M3CYW2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_166491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OMA" id="EQSFKSC"/>
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    </feature>
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    </feature>
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        </location>
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        <location>
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    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="999"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1023"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1036"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1126"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1471"/>
            <end position="1482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF08851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1734" mass="189568" checksum="D7DEB6FEEEAA3923" modified="2013-05-01" version="1">MPFADTVSSLSGRNSRASNVSGQSRSQHRSPPTSSNDTWSNAGVLSMLKTSTDTGDIGALSFNNSRLPGMPHARQRGRQGHGSKVSASGHPHITSLSSNHSYAPSQTSRVSSQWDTASTTQRRGSLTSMQSMPPSLPPVHGGKSSIPARQPSQDVDPRDNRSYSMGSAVPGGQLPRLRSAASLKSQGHEPRHINHMPPGPVPPMPENRGPFVYPTRLKRPGFRSASPALSDSYPAPHMGGPQMGRRVPGPHPPPMAAYNGYNGVYMGDYNNPQQNIRPPPRLADNPADPSYGPSQYAYQQGPVRQAPLPGMPHPMQQPYPPQYPPQSRAQYGPQYPPGYTYPPYGQVPQQSRTRGHPPPSNIGPMAHHMFHNAARMARNLPQRTDTPMTDGGPPSSDPASASSAPDSSGPPTPRDATTTVRVGVDPAFIEPDLLDLPDSSEPMMPGHKYFEYAEGRDEQAEVPHASIPPSGFVQRVKAMLESKAALEAAQQHENEKAMQLAHPQHVYLHELDVDQDQEGEVSDLADLHEMAANETPRFTIIEEFEAPAELPASPVKVAELDAMETTRITRDMIRAELSCISSADNTLQQVQPDDSTANVIKQLVERGDAPSAPIQPESSKQEITRHSRRSSRQSATSIKRRHDSVPEAITEVSMEASLPTGADYAMRFQVPIDTTDSSDETQSKDPFALDADTVTLQHQAAAAKESSGVEVIEEGKKTPGVDAAHQSVFLDLTPVSPLRQGEVVKRSSAVSPIQDEARGIDETLRVAGDDTRGEESSTSIQEAATSNTLSADYESMPPPTPRTPRTYSKSVQLHRPSTAVPETSSTNSNRFSLPGDLSTVGDTTLNSASDMITDVAVRFSLPGTTITVGKPQIIEVSPGSTPDKLNDESPKFQPHFTKQSGLRSSRRNSVTFADEIAPLNIKKSDSAKAEASSIQHKSIIRKLAPRDDHSQLTKASRDTTTDMRSNNSNNSYSTHARLGSAHLHQLPGLKEESIEDMGSPEKKRSSKKSDFPLPARIAAVKAMQERRMQDSADKAKARRNAQKHNRPLGDSKDLPSLNFSRTDLFEKLNDALEVRPTKSMDIIRRRDFTGIHCPSPRRPMSTEPLRDRYASFFNKPEDFSFCDEVGTSDEEDDEAELESASKHDNDKALVPSVQIQENTQTELEDPAASHRPLSPEDFLHVAQQASRLSIPSVAGLSERISELIPGLRNLSSLRLDFLPSETDMHPGYAGTTEVGRPDTILTNRTSAGFRTLAERAEEIVINGTHDSIAPSALHALLNKELPALPKTASVDGIAGVNTTNGKGAYLSGSMSVPVDLGKDPIRPESAFLRTKAPTTEAEVQKLLPKGMNPISRMSNRRSMIVSQPNSRPWNVDKNYPWSGNKIAIDLSVPSPAHTNTSLASEVLRERKTRSLDLPRSLVGGNDINVGITTTSPAESRFSVTTEQLTGISPSHLRHKSKRSIIGSISKKFGLTSNHTEATSRSLPGSPVPRQASVLSHRPGDRYPTSSLTPPAIAALDEVRSFFSDNSMERNRTASFRKRLTQFKGKGRTSRADHLPRTAHSLDIQGNTEYSAGSVNEARSESATMHMQYDAAGMGKAEFHFKRFGEKLRHFFAKGSVLFRSMSTRGRPRREEPRDEWLADSLYSVHESRLPVLWESLMNASIVLRLTAGRLLLDPLAVVSAPTSWRALLRRPWTAGQSLWRAPKRMMLIDDGHSRWDYASNSIMAVHPGHRRQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M3CZE5</accession>
    <name>M3CZE5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_13287</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF09041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757162.1">
        <property type="nucleotide sequence ID" value="XM_016902519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CZE5"/>
    <dbReference type="STRING" id="692275.M3CZE5"/>
    <dbReference type="GeneID" id="27899656"/>
    <dbReference type="eggNOG" id="ENOG502RXAF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_585255_0_0_1"/>
    <dbReference type="OMA" id="GACYDQW"/>
    <dbReference type="OrthoDB" id="3644624at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027796">
        <property type="entry name" value="OTT_1508_deam-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14441">
        <property type="entry name" value="OTT_1508_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF09041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="450" mass="50921" checksum="8D05D6A317853982" modified="2013-05-01" version="1" fragment="single">RPVQTANPSDTIWSIVSEDDFRQHLVALEKRTNAVPIDVMTERVKGTYKTATSSETLPLVVEKQVADDLAYIAAVSEGAQSVAAVCLEQHISLASGNECERFLNAKIAGMDIVDDAVKNMLGDIAEVLQVVARSTSTDEDRQHSTSVPVIFNIIIQQHTQKILGRLRSKKWTKPTYLDRTHKKSLWQDFANVIHRVQHIYPKKSERRVRESTVAQLTELAKIYEDFETTDTETSNALQQLVQATYRSCRLPEMSAYALKLEQSSSTPQIGAALKTLRQLEKIGAYWRIAQDLVAAASQYSAVFHRIHFEYVPPYASVPTDITYESWAGKCHVHAEVQLVVEIALQAQTHLPTSSGEGIRKIPPRTIGTSKYLCYLCHLFLHYHGGFTLLPTHGRLYDQWTVPDLKEYDFASRRKLASVLRDMDAHVRRRIEELPGVVWRAEPMTSRQNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M3D0S6</accession>
    <name>M3D0S6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_151137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758209.1">
        <property type="nucleotide sequence ID" value="XM_016906622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D0S6"/>
    <dbReference type="GeneID" id="27903759"/>
    <dbReference type="HOGENOM" id="CLU_2352402_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF10088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="97" mass="10884" checksum="FA54E2C12DABDC8E" modified="2013-05-01" version="1" fragment="single">DVHPYHLRQPAGAIELAERVGSDRTLLPHSPPEHTLLPPVSRRLGPRGTTTTGDRLAQRPCLSPGYLTLHRERPLFNRLRACAAWPAFSCRRSWTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M3D159</accession>
    <name>M3D159_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_68602</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759334.1">
        <property type="nucleotide sequence ID" value="XM_016909830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D159"/>
    <dbReference type="STRING" id="692275.M3D159"/>
    <dbReference type="GeneID" id="27906967"/>
    <dbReference type="eggNOG" id="ENOG502QQBG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039745_1_0_1"/>
    <dbReference type="OMA" id="WIESMPD"/>
    <dbReference type="OrthoDB" id="202840at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00299">
        <property type="entry name" value="GST_C_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058268">
        <property type="entry name" value="DUF7962"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25907">
        <property type="entry name" value="DUF7962"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="7"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7962" evidence="2">
        <location>
            <begin position="101"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF11213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="313" mass="33960" checksum="85ADBF6DA541962A" modified="2013-05-01" version="1">MTSVIQYDYDFSPYGQKTRLLLHVAGVDYALAETSMLLPRPALEALGITYRRIPVVAIGKDVYVDSSKIIDTALSTLGKLPQSPADKAFEVYGNNLFAEALSLIPLEMLSPDFVKDRETVFPALSRSDLNTLRPSGLAQFKSRLHEIETKILTGSSGPFINGSQISLADVHVFWVIRWAFQALGVAKEPGIDQSTFPKIFKLIESLPDPDKVKAAAKSVTPEEAHKLVMGGQYTSKTAATSVQDDGTYGIAAGTTVAVESFDSAPGSHPQYGKLVGTSIDEVVIETDSGVRVHFPKIGYIVRKLEDAPAKMKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M3D1P1</accession>
    <name>M3D1P1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_150073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759168.1">
        <property type="nucleotide sequence ID" value="XM_016905950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D1P1"/>
    <dbReference type="GeneID" id="27903087"/>
    <dbReference type="eggNOG" id="ENOG502SGJJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_368480_0_0_1"/>
    <dbReference type="OMA" id="SDSFYMA"/>
    <dbReference type="OrthoDB" id="5329403at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="598"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="306"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF11047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="756" mass="81832" checksum="0CC54E91E1630E2C" modified="2013-05-01" version="1">MTSQQNGTAANGKMGHTAKRSSGRVVPAIPFSLIRPAHQVKSLPKQHDGTVKAAPALTDPQTVSEQGQNGGSEVEQQARGVETQEADHSVRIEQKQHQEHEGREKTRSSTETPISRGSAVMSLSNGSTPEHVASQVLAQRDVLANGQAAASSPATTSSPTSGRFDMRQTRAELPPAFIPSAVQELSVSAASSQRRPSNLFQGLPIHPGTSNIVFGGNESTGSSPAPPPGAGSAFVPPPTMHHGHAHHASVPHSQRSQNGNHATPSCAARQVAGPHRQSTTHVPFHYSSRDNFAPNGHAVVNGYGPRSRSGSHASSRAGVELQSPLSNDVDRSMDSGKVMYPDSKPLFANRHFSPSFQQHMQPAPPNFPHPEMAAGFENAESMRDHVLSQFQNPALTDCKLLVLEHDGSARSELDCHRLILARSPRLLEIIINNSEGPHENKSQVQVQLTGPRVRTGPFVDAVRYLYGGQLPPYDLYNLAPTASTEDRVEVALQYIATGAWLKIHAVAQRGVEIASSLLQWDTITRILAFALDGGLGQGWPIEYGSEKMGTSSSNDHFAKPEAGGSPIHEPHSSALLGSVLEFAVHNLPPNFYMDSSAPQSDACPRLPSYPQHHESKTSLSDPRLSKIRFGEMSNENDGHQRPSFATTIVSSILLSLPFPLLKCLLEHPALAGRLGTDTVGSIMRQVVHERENRRRKTLKSRNSSRIDETADYQQVQNLYWEEVVEPSPLTRAGLRLARRRRGIDTPPSSADTDVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>M3D1Q0</accession>
    <name>M3D1Q0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">SEPMUDRAFT_88251</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 21">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 21">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associates with DNA double-strand breaks.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PI3/PI4-kinase family. ATM subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759178.1">
        <property type="nucleotide sequence ID" value="XM_016910468.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.M3D1Q0"/>
    <dbReference type="GeneID" id="27907605"/>
    <dbReference type="eggNOG" id="KOG0890">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000178_4_1_1"/>
    <dbReference type="OMA" id="SMYIGWC"/>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00892">
        <property type="entry name" value="PIKKc_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000031">
        <property type="entry name" value="Phosphatidyl inositol 3-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056802">
        <property type="entry name" value="ATR-like_M-HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057564">
        <property type="entry name" value="HEAT_ATR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012993">
        <property type="entry name" value="UME"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF125">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MEC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23593">
        <property type="entry name" value="HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25030">
        <property type="entry name" value="M-HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08064">
        <property type="entry name" value="UME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00802">
        <property type="entry name" value="UME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="17">
        <location>
            <begin position="843"/>
            <end position="1422"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="16">
        <location>
            <begin position="1537"/>
            <end position="1845"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="18">
        <location>
            <begin position="1840"/>
            <end position="1872"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EMF11057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1872" mass="210757" checksum="5DB28BFF631AFD9A" modified="2013-05-01" version="1">MLAMRACIERSDDATYVDVRTSRFAQHCLNSLRSSVRELRTAAAQTVSCLLRDSLPESLRFPNRQVVLEHLRSASTRDVASEQETLVTAWGQVAISCGEKELNLALLQLVEYLGHGNAYVCALAFSELESIATYKGLLPKELFQPFWRSIAVAVVQELHNKPQKAQQLSDLLSMDINSFLLLTQREILPFLVLTKRKDVLQRIANARGNGATIEDICMQPSTNLAAILAFLLSQSSHEAEDFAYSCLTEVAPELRNTDVVTLVAQVNPVLVACEMLKLSGEQSPDRKSRAYQAFQTFATIAERLPGQRKVHGKASKAVSTFFEDKILGILTLFSLTLECGTGAESTTEKIRCLKGLADMLVIAKGQLSAALPQIRGCLQSGLEQPALCELAFGTWLTLIPLLDEDDVMSIVNETFVLITRHWSHLTLDTQQKTHEMLSQLVKTHNTLLQENKMTLPSLQGIPLLSKFAAEFDRVRSQEDVETFCKAFTRRLKDDSDTVVLQSLEELVPFLISRQTFIHETAASELPSPVLSELLCALLDVTVKYSSTKPEAAEFCGKALGIIGCLDPNRVEATRRKGHILVLSNFENAGEVIDWIVALLQDVLVKSFNSVTNPKDQGFLAFTMQELLRFCEFPQIAELRPRASQAPEAAAKWYAMPEHIRTALTPFLSSRYVVTSNNPVNPPDRIYPGFSPDASHSFWLRSITIDLLIRAKGDNAKAIFMLFVRIIRAQDLAIARFLFPYAVLNVVIGGTTTEIKNLTDEFMATLQANSDHAAQKENIRLCSESIFSVLDYTSTWLREKRKAFNEIRSAAYKTGMSPSEFDEARDIGQMETVENFLASIPAEIIANQAIECRSYARALFHWEQYIRQERDLIPTQKMTKYHEHMYDRLQDIYTQIEEPDGLEGIAAHLSLVSEQQQTINHAKAGRWTAAQAWYELQLAEDPADVDIQHQILLCQRETGQYATLLRYANSFLDPGQSHDNMPAAIQAHLPLAVEACWMTEDFDGLKRRLLIRPEETKVDFNLGIGQALLYAAEDSAVSLQDHIRNSRTSIVEGLSMASTGSLQTCHADLMKLHVLYELEALFAVQPSDASRLMKTFDKRLLAVGAYVQDKQYILGARRAVMRLLPESFKERYSGASWLTTARLARQSKNITSAYNAVLKAYEYHERGAKVEEARLLWVEGHQRQAIRALEAAIDSGVLEVEDPDSSVPDAVSATTNSMSEINGHKQSPLLGKALLLLAKWLDASGQSQTKDMTDRYQLAARRHQRWEKGHYYLGKHYSKLLDVQKSLPREKQIATYLSGELTKLVIDNSLRSIPFGNKYWHETIPRVLTLWLQLGMDSLKAARGEDDAIFQKRKKSLQACNRQLQKYFERVPPYVFYHALPQLISRITHPHPDVWHHLCNILVRIISTHPSQALWSMLAVPKATDKLRIERGKEVLLKLREQKTQPKHDASHVDLKTLIVHSQRLCDGLLLACEQPIEARAVHVSLSKNLAFKLNLAPSNLVVPVESTLTASAPAASNSDSIRRHKAFTQDKITIQAFQDDVLVLNSLQRPRKITVRGSDGKLYGLLCKPKDDLRKDQRLMEFNGIINRALKRNTESSKRRLFIKTYAVTPLSEESGSIEWVEGIKPMRDILLSAYNGKGIRPNYNEIRKSLEIASASEENAHIFTEEVLSQFEPVLHEWFTETYPEPEIWFHARLRYARSAAVMSIVGHILGLGDRHGENILLMEDTGGVFHVDFNCLFDKGLTFEKPERVPFRLTHNMVDAMGPYGYEGPFRKSSELTLGLLRQERDTLMTVLETFVYDPTADFVGKKRRNTPGVPDTPAEILESVKTKLKGLLLGETVPLSVEGYVDALIQQATSHFLLASMYIGWCSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M3D334</accession>
    <name>M3D334_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cleavage and polyadenylation specificity factor subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cleavage and polyadenylation specificity factor 100 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_149259</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760761.1">
        <property type="nucleotide sequence ID" value="XM_016905444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D334"/>
    <dbReference type="STRING" id="692275.M3D334"/>
    <dbReference type="GeneID" id="27902581"/>
    <dbReference type="eggNOG" id="KOG1135">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002227_3_0_1"/>
    <dbReference type="OMA" id="QSRHNME"/>
    <dbReference type="OrthoDB" id="64353at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16293">
        <property type="entry name" value="CPSF2-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027075">
        <property type="entry name" value="CPSF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025069">
        <property type="entry name" value="Cpsf2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035639">
        <property type="entry name" value="CPSF2_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922:SF1">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13299">
        <property type="entry name" value="CPSF100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Beta-Casp" evidence="6">
        <location>
            <begin position="279"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="481"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="612"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="481"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="499"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="637"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="675"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF12640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="964" mass="105727" checksum="3468119E1F25CB4E" modified="2013-05-01" version="1">MFHFTPLLGAQSDSPASQSLLELDGGVKILVDVGWDETFDAEQLHALERHVATLSVVLLTHATLDHLGAYAHCCKHIPHFRNVPVYATTPVVNLGRTLITDLYASAPLAAGVIPARAIAANTALAPDATPSLLFPAPSADEIAAYFGAIHPLRYSQPHQPVPSPFSAPVGNLTITAYSAGHTPGGTIWHIQHSLESIVYAADWNQGRENLLSGAAWLSGGSNITEGLQRPTALICSSRGVEKTETLTRKKRDEALISLIRETIAQGGKVLIPTDSSARVLELAFILNHTWRENVEGPHADTYRNARIYMASKTSKSTVRQLSSMLEWMDDAIIRDAEAAMSKTQADEGRVPNLLDWQFIQQIESKNKLDQALRRRRPCILLASDASLEWGFSRQAMEKLAEDPRNLVILTESVAQTNTSRSSLAQQLTEFWRASSKSTSQTGAKVVGTDGRSIQLRHATAESLTDDEDVMYQQYAARQRQLRSNIQGDSTSNDTATAELAEEQAEESSDDDDEDEDPEHQGRALNLSAQMTQSNKRKAGLSDAELGINILIRSKNVHDFDVRHRKGREKVFPFVQRKPKSDDYGDIIKPEEYLRAEERDAVDGVDMRADVKQEATAVGQKRKWGDAHGNTKGKKDRKPLPDKRQKVEEKHAPDDIDALIAKATGVVGGGDAPESGSEDDESDYEPDEGEDKPPRKAVFVTSQLALQIRIAHIDFSGLHEKRDLQMLIPLIRPRKLILISGSVSETQILAEECRQLLFKGGEPKSDVFAPVIGEVVDASVDTNAWTIKLSRQLVKKLTWQNVRGLGVVAVTARLDAEPLEDGSRDAEDENVKKKLKMIKGDAEGGDEDSKAGRTGIPAVPVLDLVQSISTTSHQRATQPVHVGDLKLADMRKMMIDSGHSADFRGEGTLLIDHTVMVRKSPSGRIEVEAGPAGLRQPQFRTRDYEGSFYAVRKLIYGGLAVVAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M3D4U5</accession>
    <name>M3D4U5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_148594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761346.1">
        <property type="nucleotide sequence ID" value="XM_016905018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D4U5"/>
    <dbReference type="STRING" id="692275.M3D4U5"/>
    <dbReference type="GeneID" id="27902155"/>
    <dbReference type="eggNOG" id="ENOG502R9AD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_362912_0_0_1"/>
    <dbReference type="OMA" id="RATTHFT"/>
    <dbReference type="OrthoDB" id="3946749at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022124">
        <property type="entry name" value="DUF3659"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39461">
        <property type="entry name" value="LEA DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G04920)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39461:SF1">
        <property type="entry name" value="LEA DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G04920)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12396">
        <property type="entry name" value="DUF3659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="515"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="608"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="377"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="557"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="621"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="632"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="653"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF13225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="671" mass="71750" checksum="14C5CCE956087A48" modified="2013-05-01" version="1">MGLFSRKTKAKPVQNEVKAEEKKEIEIPPLPYKHISKHAAADSAAQGSRSDSYEDRTQIALANRQRMANSPYDTSLSNASFVQDIAHNMARGSRSRPASPTAERFGVSRSYSDDAHYHNLHRNSTGPSHKSRAGAQAPKLQRSSTDYFARSPHTHGKQPAEAGYYSYSSDSGYESAEPASAMHSRAPSEHNDFSKGHAAYSNLLPELALNGEHSPVDLNSDARSIRSTRSVSKRTRFEDSVDPMPALDQLQQYRQDSDSSLGLTSHHEGSSPPLSILEGFKVNKKGKILNEEGEPIGELVEGDLLDCVRQKVNANGEVLDEYSRIVGHARTIATPTTTQQNVLPATETGTPIAQASPVLTRPQSVQQPVEVTKSVEEPVQSEPVAAAVPAQEVQRSDSAGETWLPAVTHQVMPQSNAVPVLSLPTPEPARVARSASERSLSELSKSYVRPAMRSVPENKVPIDDAFPASPSSYSYKGEIPATDGPSAAGKLLLGPSSYAKLALVGGHSASTLFPPTRPVGISSRRSTSHIGTSSSANRLPLQSAMKKRSQYDYTFDFTPSDSGSEAPSSDDGRMLTLGGHSRSASMHTTGSMSRPRTYFTHAGKVTIDPDDLAPSKGKQSATAAAAAAAAAAPPPPPPVPAVPTAESLDEKKKGNRKSFLSRRKSKTAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M3D4Y4</accession>
    <name>M3D4Y4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Proteasome regulatory particle subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_149462</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761050.1">
        <property type="nucleotide sequence ID" value="XM_016905567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D4Y4"/>
    <dbReference type="STRING" id="692275.M3D4Y4"/>
    <dbReference type="GeneID" id="27902704"/>
    <dbReference type="eggNOG" id="KOG3151">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046003_1_1_1"/>
    <dbReference type="OMA" id="HIMDGYF"/>
    <dbReference type="OrthoDB" id="8775810at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.990:FF:000001">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006746">
        <property type="entry name" value="26S_Psome_Rpn12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033464">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12387">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12387:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="75"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF12929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="273" mass="30314" checksum="B055E29950D06878" modified="2013-05-01" version="1">MAENELKQILSHLTSIKSNAELQKAPQLLSRAKLNLLKLNALVPSEELKPQHLPYALAVLEAGALISIRLRDTDSFTRYFQQLQPFYAIPRATRERFGAKDSQEGKVTGLYLLLLLSVGDYAGFHTVLEGIEVSGSGIEKDEFVKYPVRLEQALMEGSYDKVWAETTGERVPSEEFGVFSEVLIDTIRSEIASCSERAYPSLPISNAKNLLFLDSEGAVIHFAQSRGWVAKDGRIYFPAQEADALAAEKDVMSNSDVVIENTLGYARKLETIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M3D5J9</accession>
    <name>M3D5J9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein uL14m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_148544</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761285.1">
        <property type="nucleotide sequence ID" value="XM_016904987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D5J9"/>
    <dbReference type="STRING" id="692275.M3D5J9"/>
    <dbReference type="GeneID" id="27902124"/>
    <dbReference type="eggNOG" id="KOG0901">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095071_2_0_1"/>
    <dbReference type="OMA" id="IVCVVQK"/>
    <dbReference type="OrthoDB" id="274765at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00337">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.150.20:FF:000005">
        <property type="entry name" value="50S ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_uL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005745">
        <property type="entry name" value="Ribosomal_uL14_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_uL14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_uL14_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01067">
        <property type="entry name" value="rplN_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L14/L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL14M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF13164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="136" mass="14657" checksum="20BC7691CD4BA3BA" modified="2013-05-01" version="1">MIQLKTMVNVIDNSGAAIAECVKVLKRKTPARVGDRIIVVVQKQRNFGPESGGGGGSVSVSAANKVRRGDIRHAVVVRTKKEFVRKDGSVVKFDDNACVLINKGGEPIGTRLNGIVAREVRDKGWSKILSLAPMHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M3D5K3</accession>
    <name>M3D5K3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_148722</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761541.1">
        <property type="nucleotide sequence ID" value="XM_016905106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D5K3"/>
    <dbReference type="STRING" id="692275.M3D5K3"/>
    <dbReference type="GeneID" id="27902243"/>
    <dbReference type="eggNOG" id="KOG1289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004495_6_1_1"/>
    <dbReference type="OMA" id="MSCLIWR"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF4">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="458"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="505"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="536"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="27"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF13420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="571" mass="62858" checksum="3D5358B332458407" modified="2013-05-01" version="1">MNNMFEQQDRGMHANTHSTSIMAMPVSKYTSRKNSRHDVRELSEVSPGGSKGPKEIQAELDELDDLATDLSDPGRMTSFDVRDMSRMGKRQEMRRVFRQFSILSLTTVIMASWEFLLTANTQGLVDGGRAGLFWSYLWTLCGFGMVIASMAEMASMAPTSGGQYHWVSEFGPEKYQKFLSYTTGWLSTMSYQAGNASGFFLAGTIIQSLAMVNYPEYAAPNWQSTMCVLGVVLVSGIFNIFFTRFLPILNNITMVVHLTGFVAVVVVLWVLAPHPPAYDVLMDFQNSGGWPTTGLSLMVGQISAIAALGCSDAAAHMSEEVSDAGLSVPRSMMWTFYINGSTGLVFLISVLFAIPSVTDALNDPTGYPFFYIFKLAMPDTNIGTNILTVLTVWTLMVGNVSFTASCARQAWSLARDRGLPCSTWISRMDSRVHIPVNATCITLVITILLSLINLGSNAAFNAILSLQLSALMASYAICITCMVWKRLRDPTSLPQARWSLGKLGLPINVVAMCYSTFACFWTFWPNSTPVDAASFNWAPVIFVLVMMFAMVTYALQGRHQFDGPVALVKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M3D5W5</accession>
    <name>M3D5W5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Histone acetyltransferase type B catalytic subunit</fullName>
            <ecNumber evidence="2 7">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_148625</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalytic component of the histone acetylase B (HAT-B) complex. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the HAT-B complex composed of at least HAT1 and HAT2. The HAT-B complex binds to histone H4 tail.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the HAT1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="2 7"/>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761390.1">
        <property type="nucleotide sequence ID" value="XM_016905038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D5W5"/>
    <dbReference type="STRING" id="692275.M3D5W5"/>
    <dbReference type="GeneID" id="27902175"/>
    <dbReference type="eggNOG" id="KOG2696">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036024_2_1_1"/>
    <dbReference type="OMA" id="WTCDAND"/>
    <dbReference type="OrthoDB" id="10253098at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.360.10">
        <property type="entry name" value="Histone acetyl transferase 1 (HAT1), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019467">
        <property type="entry name" value="Hat1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037113">
        <property type="entry name" value="Hat1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017380">
        <property type="entry name" value="Hist_AcTrfase_B-typ_cat-su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12046">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE TYPE B CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10394">
        <property type="entry name" value="Hat1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038084">
        <property type="entry name" value="HAT-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histone acetyl transferase HAT1 N-terminal" evidence="12">
        <location>
            <begin position="26"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="473"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="493"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with histone H4 N-terminus" evidence="10">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF13269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="523" mass="59555" checksum="12CEABF80873166D" modified="2013-05-01" version="1">MARQPSTDMDDDDELTAEIQAQVDEWSSNSNECLTVQLTRRDGSIVASFQPEFTYAMFGNEEAIFGYQDLHIILSFVADSLEPKLDITYEKKFPSQGDVKPTDIKLALSDFLPSSAFGRTSSHKKDTSFKPPGEKIHTYTRNGSRFETYCASLADSAAREILENMQILVPMFIDGGSTLELDQDWTAARWKLFLVYEVSDATYTFAGFGTSYRNFTFPERKKAVQFDPFSPSSQALDAFLAVDGGTNQFAQPADFDSPLDLPSRERLSQFLMLPPWHGKGHGQELYKAMFTHLTIPDSVREFTVEDPNERFDDLRDFCDLLYLRANVPEFAELRIQTGIPPEKLEARANIPVELIVPAGVRKDIMARTKIMPRQFDRLVEMHTLSHIPHQHRTRSRLTKKMNATNDDDKAYYLWRLYAKHRLYNFNKDQLAQVEHEERVEKVESALDSVQHQYSETIAKVEERERAIAAGEIETSDDVAAEPGATKRKRWTVVDDEDEVMEETEASGNGQADSNGHKKKARVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M3D652</accession>
    <name>M3D652_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_148883</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761776.1">
        <property type="nucleotide sequence ID" value="XM_016905204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D652"/>
    <dbReference type="GeneID" id="27902341"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012970_1_0_1"/>
    <dbReference type="OMA" id="YWIGYYC"/>
    <dbReference type="OrthoDB" id="4078873at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000284">
        <property type="entry name" value="Siderophore iron transporter mirB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF107">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="406"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="461"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="502"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="574"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF13655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="610" mass="67722" checksum="5292B88EBD2D2CFA" modified="2013-05-01" version="1">MGVFDQIRGRKTLNHTAETLAQPEPLTDEKQATDQATSASASESDNDNLSLEAQNEKEIQRHPDQVTADAHKGIQKAEAAALVWTKPVLYATFAWIWVCFFMLAFQSSVMSYASVAAYSSFQTAPAYTTAQILATIIGGVLKLPIAKLLNIWGRTEAYMTFFGVYLLGIIIIAASNGPNSYAAGYVLYWIGYDAVYLILDIFVADTTGLRNRAFAWGFVSTPFICTAFTGPLCANAFLSVTTWRWAVGAFCIIQPVVFVPLAVVFKFYQKKAEKMGLLQTSDAGRTKLQSLVHYFHEFDIIGCILLMLAFILFLLPFSLQSYGRADFKSATFIAMVVVGACLFPVFYIWERYFARVHFVRWELVRERTVLGACSLAAVLYFSFYSWDLQYYNYVKVTYALSVTYAGYMGQIYNVGSCFWSVVFGAWVYYTKHFKYTCLCFGLPLMFLGAGLMVHFRGGDYGIGYVVMCQIFIAFAGGTLVIGEDMAVMTAADREGVPMMLSIIYLASNIGGSIGTAVSTSIYGNTFPSALSRALPADLQGKVQELYLGGYLTQELFVPGTVERTAINYAWGQTQYYSCISAVSILVLGIPAIAMWKNYRVDKQQNKGVMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M3D6W2</accession>
    <name>M3D6W2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_132877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761735.1">
        <property type="nucleotide sequence ID" value="XM_016902521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D6W2"/>
    <dbReference type="STRING" id="692275.M3D6W2"/>
    <dbReference type="GeneID" id="27899658"/>
    <dbReference type="eggNOG" id="ENOG502TFTN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_357143_0_0_1"/>
    <dbReference type="OMA" id="FRIERCI"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053083">
        <property type="entry name" value="TF_kinase-domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44305">
        <property type="entry name" value="SI:DKEY-192D15.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44305:SF24">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE C03B1.5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="220"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF13614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="908" mass="102696" checksum="7B72AF36D6434155" modified="2013-05-01" version="1">MTTFLSYASSLGCKNEDALALIRRHCSKDSSIRREGEYHDHDDADLLPTPQRLRQAFPADAESHIRIQDFLHCLCVLCKPQHGALEDDDRERLLPHEILSNDKTLKAFATLILSGCLFALREYVKSEDDLKTFTKFIGNPGRALRRRLFRLVGTDDALCPHTEETRPATTLLSQQCVTCLASTFRECVGRKFRLQTIKTLRKSDKIEDYVLSRTNLPIVLEHEDQIDKPSRPGVRFSRCKIEATHCLSEELTQHELFRKRYRLLPSDGHHDHEPTPSDLETVTLEEKEASIALALGSLDHANIAKVILVFREDADDPHLSLLFKREQHNLEEYLQEFTSANLLGGFVSRVWEHTILLDHGLWRNLLGIVDAVATIHEVAEGGKQPRRLGPPIFGHFDIKPANILVSDGGTLLLTDFGQAASRTVGTSDYAPPEHELSNRVELVPSYDVWSMACVLLQALVFIRSAAEGGEQEGKNAVHTFYSQRLHETEHNQAGAFWIKNHHGPGSSLRKAVDNELTQLATRRHPKTKVVVNQLRQMLSVNPVRRPTIRECLKVFGSSGLGRDIFRTPGDINVEPELANWITSFSTEVQREPVPCRLQLYRALQSRRGPPEVNLTLEYEGEPSTHSRTDMRSVHEVALVPIALFNTNIVAGRSFSQSSQTSRDGTTLRLGFMNFFRGVTLHFLAPATYLEFMTLMTHQMILPDARTDHHDTKGAGVRFKSCKVVERRDWPHRNREHEFTDGIVQVWEALSPEAYESRYPHVDSTLTHEPLRRAPPVTYDTVQRLPVPPPAQISRYKMALFGLEKASRLRCCLIADVGTDSYTLESKASAHSLEFIEKSEAKFRSVVYRSQSPESYPGFPISPDVLTTQIKDLGIRTSSILLEMERDCNHHRDLRRLIAGGPGTPIKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M3D795</accession>
    <name>M3D795_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Casein kinase II subunit alpha</fullName>
            <shortName evidence="10">CK II alpha</shortName>
            <ecNumber evidence="10">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_148946</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="10"/>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761870.1">
        <property type="nucleotide sequence ID" value="XM_016905246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D795"/>
    <dbReference type="STRING" id="692275.M3D795"/>
    <dbReference type="GeneID" id="27902383"/>
    <dbReference type="eggNOG" id="KOG0668">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_70_4_1"/>
    <dbReference type="OMA" id="ECHMIEW"/>
    <dbReference type="OrthoDB" id="10254671at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006356">
        <property type="term" value="P:regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14132">
        <property type="entry name" value="STKc_CK2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000059">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000088">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045216">
        <property type="entry name" value="CK2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="32"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF13749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="328" mass="38553" checksum="BE83AB8657CAFDFC" modified="2013-05-01" version="1">MARVYADVNQQMPRAYWDYDSVNISWGVLENYEVVRKIGRGKYSEVFEGVNVVNYQKCVIKVLKPVKKKKIKREIKILQNLSGGPNIVALLDVVRDSQSKTPSLIFEHINNTDFRTLYPKFQDYDVRYYILELLKALDFCHSKGIMHRDVKPHNVMIDHENRKLRLIDWGLAEFYHAGTEYNVRVASRYFKGPELLVDFQEYDYSLDLWSLGAMFASMIFRKEPFFHGNSNSDQLVKIAKVLGTEDLFDYLDKYDIELDAQYDDILGRFPKKSWQAFVNSENQRFISNEAIDFLDKLLRYDHQERLTALEAQSHPYFDPVRPVEISAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M3D7R9</accession>
    <name>M3D7R9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_162399</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762351.1">
        <property type="nucleotide sequence ID" value="XM_016908003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D7R9"/>
    <dbReference type="GeneID" id="27905140"/>
    <dbReference type="eggNOG" id="KOG2615">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_54_5_1"/>
    <dbReference type="OMA" id="PWKELQP"/>
    <dbReference type="OrthoDB" id="10262656at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17330">
        <property type="entry name" value="MFS_SLC46_TetA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF8">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G03730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="464"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="488"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="16"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="516"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="517"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="586"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="621"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="634"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="656"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF14230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="672" mass="72774" checksum="1E2FF4D145074813" modified="2013-05-01" version="1">MAPATRRRERKLPVQQLSILAICRFAEPLASTSLYPYLPEMVQSFNIPQNEVGKWAGICAACFSLFQALFGIPWGRFSDRYGRKPAILLGLTSTMLTSLLWGFSKNLPMAIVARALAGAGNGNVGIIRTTVAEMVPFKELQPRAFSLMPLVWNIGSIFGPTIGGSLANPLNVRPGEHTDSKNLFAQFPYLLPNLVSAAFFAVGITTGILFLEETLESVQGRRDHGLLLGKTISSSVRRSVAKLQEFLRLRSPRSDRGLHAADETDPLLKRPASADDSEAASVAYEAKPRVAAPTWREVMNRQAFINLIVYTLLAMHAMAFDQLIPVFMQHDPIGSPDSTPYEFPLKFAGGFGLDHFQIGLMSTGYGIVGMFVQFFVFPPLARKYGVLIWLKIVVIAFPVIYLLTPFTALLPTIGSQVACMFTAMMLKCLCGIFAFPCSTILLTNSATSLRTLGTLNGIATSASALGRAAGPALAGLVYSAGVKKGYVIAPWWCLSFIAIVAAVPVWWLVEGEGFGGDNDEVSDDEEEDEDEDAETAEAWQAVITECSAEAQGKSRVPGPIPRGISQAHEDEESQQERSYGGLAPLTRTNTTGSTVMMSDADDDEYDNRSGTPSRTRSRRASGAERSDGGDSPKVSRRGSSRVKRRISIPVMGSASRRYSSSLGQSFGSAGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-05-03" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M3D840</accession>
    <name>M3D840_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_147883</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762155.1">
        <property type="nucleotide sequence ID" value="XM_016904573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D840"/>
    <dbReference type="GeneID" id="27901710"/>
    <dbReference type="HOGENOM" id="CLU_1248006_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF14034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="222" mass="23486" checksum="F3FAEA3AC368B6D9" modified="2013-05-01" version="1" fragment="single">MCGVTPTTRTIIRQCHSGPSKSQCSLSLLVIRAGIGADPILCSMRCTFGVNTPTSMLPAREVMNEEPSERRDGCECLNVSACMLNRLCAHIVAQDAGSFDEHVVLYRSVARELSHDAARGDGGDRDRHAAHVRAVREDAGSPAGHQRLRGLRAALRGGMRRRRGGAGVPVPRHGERSGELFWRPAGPPETSGGGGVDGGDVNHVPQSGDEAGGVESDAGEVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M3D8N9</accession>
    <name>M3D8N9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_115765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762616.1">
        <property type="nucleotide sequence ID" value="XM_016901196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D8N9"/>
    <dbReference type="GeneID" id="27898333"/>
    <dbReference type="HOGENOM" id="CLU_2348031_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF14495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="97" mass="10694" checksum="31C2E9D413EC617E" modified="2013-05-01" version="1">MTDPAISTRSTGLTKSQHERPFAPDIIPQGNLLGVDAESRRSMEVALMRAIAPGDHSARDSALWSLHQHGPLQAHARTSWPVEEENDVALTRRTRMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M3D9S2</accession>
    <name>M3D9S2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_148283</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762745.1">
        <property type="nucleotide sequence ID" value="XM_016904823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D9S2"/>
    <dbReference type="GeneID" id="27901960"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_1_1_1"/>
    <dbReference type="OMA" id="MGVRQPN"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF130">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="393"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="462"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="103"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="33"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF14624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="492" mass="53245" checksum="4FDF57EDE2B36087" modified="2013-05-01" version="1">MSDEYDDHQDGNEKGTEDVRSGSTTAGSHKSLSIRDDQAELEEVSLHDEQDADEIRSKHESVPRQSSQDLKRVASNVLTKVASRFTTRSIVNPPPAPDGGVSAWTQVAMGWIVVFTSWGWVNSYGAFQSYYTLTLERPGSTISWIGSLQNFFTFFIGVFSGRASDAGYFMPVVILGILVQLVGIFLMSLSTRYYQFLLTQGVMTGIGGGLFFTPAMGVVGTYFSTKRALAIGIVTTGNSVGGMIYPVLVQQLLPKLGFAWTTRVLGFLNLGMLSIVLVFMRPRMPPRKSGPMVDFSAFKEPTYAFLVAGLCLVMWAVYFTFYYLSSYGIEVVGMPFNAAITITILVNGVGVPARLIPPLFASRFGQLNTMIPIFVYLTIVSFSWIAVRTSAGTYTFAVFYGIGSSAFQCLLPSTVASITPNMNAFGTRLGMAFGAISFATLTGPSIGGAIQNAMGGKYLGAQLWSAVATLTGVAFVVTSRMVKARGKIHSKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M3DB08</accession>
    <name>M3DB08_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WLM-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_38231</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763381.1">
        <property type="nucleotide sequence ID" value="XM_016908696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DB08"/>
    <dbReference type="STRING" id="692275.M3DB08"/>
    <dbReference type="GeneID" id="27905833"/>
    <dbReference type="eggNOG" id="KOG4842">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056790_0_0_1"/>
    <dbReference type="OMA" id="GMQKHPF"/>
    <dbReference type="OrthoDB" id="49605at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013536">
        <property type="entry name" value="WLM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47795:SF1">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47795">
        <property type="entry name" value="UBIQUITIN AND WLM DOMAIN-CONTAINING METALLOPROTEASE SPCC1442.07C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08325">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51397">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WLM" evidence="2">
        <location>
            <begin position="142"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF15260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="371" mass="42022" checksum="2FCBB01942456E1B" modified="2013-05-01" version="1">MSSTSGLSQDITSDLENDAEPQALFHLTIQLHNKPLDIPIYHQDATLQDLSDTIAEEMHIPPAHQKLLITPKVGLLRPPFKDPNLLVTSLQDKKIVLMGATTAEVSELASDIADRKARIDRRRAALQAGRKVQVHKHRDWKKISEEAQFTFHTIRPLDYLPNPEKSLRYLQLLANDAGIKASMRTHGFSVGLLTEMNPAEHTTHQSRTLGLNRNRGEVIELRLRTDAYDGYRDYKVIRKTLCHELAHNVWGEHDARFWKLCKEIEAQVERNDWRRGGKSVGGEEFYHHRHRAGDHDDDDGEDVFDYDHADEGGWEGGEYVLGGSSGGGGEVVESLSRREILARAAEERMKKQREAKALEQKSNHESGTKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M3DC49</accession>
    <name>M3DC49_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Autophagy-related protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_161774</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763756.1">
        <property type="nucleotide sequence ID" value="XM_016907957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DC49"/>
    <dbReference type="STRING" id="692275.M3DC49"/>
    <dbReference type="GeneID" id="27905094"/>
    <dbReference type="eggNOG" id="KOG2896">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009375_1_0_1"/>
    <dbReference type="OMA" id="HYRFEYG"/>
    <dbReference type="OrthoDB" id="72772at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000323">
        <property type="term" value="C:lytic vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035493">
        <property type="term" value="P:SNARE complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018791">
        <property type="entry name" value="UV_resistance/autophagy_Atg14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157:SF5">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10186">
        <property type="entry name" value="ATG14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="92"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="353"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF15635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="646" mass="71530" checksum="A0DD08A2FBD55550" modified="2013-05-01" version="1">MAQHTSPSRADASWLLPTNRKLRNLIAISLRNISLAPASPVRKKGQVFDDDALPQTLKSPAKLLALREQKAMGHSRSSTDLRAVLEEENALAADDDGASSVVDSVSGSPVASKSNAKEKVQKPATTAPTRPPFRTLRRRSTLEWASATPQRRQERLEDVTKGRMVDVFFSLHVQDVEEPIYISETVEHTMNPTFRYVDWDACGPGVTRLSSVALRVWIKRGSCTAWQQLLQLNIALEGLHYLGRTLDTLHSPLPENAIILQMTDGVYTAPTGSLAELAPPGPRNAKPLSSTRILPTSSFDALLRLSKLDDSIQDALATRDQISNDLNALLQSNEKALADRDEVAEAEDRLKTIDFAKKTVEKQLEKARKQQEERRTSLSTRRALMASDISTRKSDHQSIQKTRPDFSSMREEHQAKVMAIQNQRRRICEGLLHIYPIEQLPGKVLSFSIGGLHLPTSDHLDSEPPEIVAAALGHVAHTLQLLSFYLSYPLPYPVTPRGSTSFIHDPISILQTKNAITTEKAEDKLRTYPLFSKSMPRFRFEYAVFLINQNVRVFLESEFRLRILDVRQTLANLKYLLYVATAGEGELPARKAGGVRGLMRVPAMHRAGSADSASSGLSGLTLLSNGKARSHGGAADRLREISAKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M3DF08</accession>
    <name>M3DF08_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_124208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF16109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764230.1">
        <property type="nucleotide sequence ID" value="XM_016901896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DF08"/>
    <dbReference type="GeneID" id="27899033"/>
    <dbReference type="eggNOG" id="ENOG502RXNF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061843_2_0_1"/>
    <dbReference type="OMA" id="AYESTMA"/>
    <dbReference type="OrthoDB" id="2444812at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF16109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="219" mass="24462" checksum="F59E50AE0FF5E709" modified="2013-05-01" version="1">MAQPKADKHQKNLSRYKWFKCENPSQTPDTPAHYYTNTETGASSWEEPQEPYWVYNIELGGPDPCGLQYPAGVERPGAEQTLAETNPLQYNPKIHGNYDPNADYAKYTSQRLAQQSGGATTTLTTMPGHTADYTAIMALNARTGSTQPSHLTADRHTEAAKSGRQMNAFFDVDAAANAHEGKSLKEERKAKKLSKAEVKAFNEARKEKKQKKRMAFYKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1QD61</accession>
    <name>N1QD61_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_120037</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757287.1">
        <property type="nucleotide sequence ID" value="XM_016901564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QD61"/>
    <dbReference type="GeneID" id="27898701"/>
    <dbReference type="HOGENOM" id="CLU_1982959_0_0_1"/>
    <dbReference type="OrthoDB" id="3650741at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF09166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="126" mass="14803" checksum="FA541FF3442330CF" modified="2013-06-26" version="1">MASRTERTTRELIQTLPQELFALIYEEVFAATPASIFVLKHEVRHRRILFPTALHVDRASRATYARSFFAVTQFIFRRPEEGRSWLAVVDTLKTNSRVLVEHARGWVIESARDWVIEPARDWEFIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>N1QD75</accession>
    <name>N1QD75_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Acid protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_151317</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
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        <text evidence="1 6">Belongs to the peptidase A1 family.</text>
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    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Aspergillopepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000026">
        <property type="entry name" value="Endothiapepsin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
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        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034163">
        <property type="entry name" value="Aspergillopepsin-like_cat_dom"/>
    </dbReference>
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        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF1">
        <property type="entry name" value="ASPARTYL PROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
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        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0064">Aspartyl protease</keyword>
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        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110652" evidence="8">
        <location>
            <begin position="18"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="9">
        <location>
            <begin position="130"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF09201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="448" mass="47788" checksum="F11EC9DC3E7FA1E1" modified="2013-06-26" version="1">MFFLFFFTFVLATLAVALPSPLHKRSFKAPVRGRSSQGPLDDILRVHQKYQWAYAVGAAPVITTTTRLAPAPFPTSIVPSTTSATIGTLTTVSVPSSPAPAPPPYPNSTSTDGNEDGEVLATPEANEIEYLSPVTIGGQSFNLNFDTGSSDLWMFSSLLPASLIGNHSAYNPSLSQTYTELENATWSISYGDGSGASGTVGFDTVDVGGTTVDRQCIELATRISTAFTRDPASDGLLGLGFSSINRVYPTPQKTFFENVMNDLSEPLFTANLMDDSGAGTYEFGVIDESKYKGDIHYVDVDNSQGFWEFPVSGIRIGANDTLTCNGKCKSAIADTGTSLLYLDSDVVSTYYAKVAGSQMWDLSTYIYPCDSTLPDLSLDFGGHYITIKGEKMTYLAFTGAVNDGPAGQCMGGLQAGPSGLQIVGDVFLKQVFAVFDGGNMRFGVAEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDM0</accession>
    <name>N1QDM0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_72382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016909989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QDM0"/>
    <dbReference type="GeneID" id="27907126"/>
    <dbReference type="eggNOG" id="ENOG502RM52">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1994033_0_0_1"/>
    <dbReference type="OrthoDB" id="3880925at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="125" mass="14179" checksum="4C702B17A1B92334" modified="2013-06-26" version="1">MLRDQALHRPRVIKQRSSEARRASYLRQREGFVPGSDAVVLETSTAVRETSPDPPDHADFSKMDIPKRTSSTMCTSNLPRISRDLKTLTRTVSKEHGTLSQSVRRRRPSLPFQSPVKQSTDSHTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDQ2</accession>
    <name>N1QDQ2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">SNF2_N-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_51941</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EMF09645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_016909209.1"/>
    </dbReference>
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    <dbReference type="STRING" id="692275.N1QDQ2"/>
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    <dbReference type="eggNOG" id="KOG1001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_3_3_1"/>
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    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF17">
        <property type="entry name" value="HELICASE-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="107"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="546"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="662"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="602"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="832"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="611"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="868"/>
            <end position="877"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF09645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="877" mass="98799" checksum="B9BEC1A20B54424B" modified="2013-06-26" version="1">MTSSQNILGTATNVFRDTEANAGLGDQPTFANTTRRADALKQLIASVPAENRKIAATDRRFLDEACKAFDGTGACKAGPDGNWLVKGMRTSLKHYQVLGTAFMRKREHETQQPRGGILADEMGLGKTLMMLANIVNGKQTIRDKGTPKCTLIVASPALCNQWAAEISKHTLSKKQDRLVEHAKKHGLDRVVQHRAGFRLSPDEATAKRCIEEADICLTTYYDICKSYPKAVVPAELTTAAQKDQWWKGFYEENKGVFHQVTFNRVVLDEAHAIKNHKGHTSLACRALEATHYWAITGTPIMNRLTEFYPYFKFLREPYTGSFKIFKENFSTPDDPDGTARLAVFLRKIMIRRTHLDKLFGARLLDLPQPKQTVVWLSFNDTERQIYEIVKMRFIQRINTISKQENGVNCYSHIWTMVLRLRQLCAHILLVQDSIVDLLKREDFEKLNALCQRQVNEDEGASILLHLRHVLSKSVNEELDTVEAGAGGVGTVIGATQTAPINAVEFHHSAGQSSAGGRHGRKYDISPYMKDLTQSGHLRSIQKRSPCCACRQSPPHNPQVTSCFHIVCLFCIRELQNAAARNHKDFASCPECGMNFTSVTPCQPQPEYGDDSSSSSATPSNAGGSTDNVHTSKSKKDDNNKNNINDWIGLKGEILPSTKTIACKAQILEWLQTDPTSKIIIYTQFIPVIRILSQVCHSEGWGYVTYQGSQTQEARKNALSRFDSDPTCQILLSSLRCGGLGLNLTMAQYVILIDPWWNSAVEQQAFCRVFRIGQRRETRMTRFVVENTIDAAMMEMKERKEMEIDTVMENPRLKEKLTVEELMRMFGEVRTDEGGRPFIFAEGEEGGSEERQRQQQQQQPNEVLRNGGDEDDEDEVEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDT9</accession>
    <name>N1QDT9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL46</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_89354</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL46 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758447.1">
        <property type="nucleotide sequence ID" value="XM_016910498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QDT9"/>
    <dbReference type="STRING" id="692275.N1QDT9"/>
    <dbReference type="GeneID" id="27907635"/>
    <dbReference type="eggNOG" id="KOG4548">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040204_1_1_1"/>
    <dbReference type="OMA" id="HPFENAF"/>
    <dbReference type="OrthoDB" id="414075at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04661">
        <property type="entry name" value="NUDIX_MRP_L46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040008">
        <property type="entry name" value="Ribosomal_mL46"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021757">
        <property type="entry name" value="Ribosomal_mL46_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033650">
        <property type="entry name" value="Ribosomal_mL46_NUDIX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13124">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L46, MITOCHONDRIAL PRECURSOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13124:SF12">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11788">
        <property type="entry name" value="MRP-L46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Large ribosomal subunit protein mL46 N-terminal" evidence="9">
        <location>
            <begin position="71"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="37"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF10326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="380" mass="43124" checksum="68EFBC2CDF5D10DD" modified="2013-06-26" version="1">MNAGHQSARRLAASNVLSRDTVCSSCLHQLSRHRRHASSAVAAQLQPSTPSHPSPPPVTRTGPRKAFRVLCSPVLSRPPQITRELTPFEKAFYLYQKRLNERLVLPFTRYFYYKKDTPQDLEWKRKVAARRGVAARDVGAYNAYADDGWNDEVPIGSRLGEPDDIVDKLIRDAEGKTVVMDEGGIVGDEESGGEAIAEDAQEGEEIKKPVADLTIERPAPRRTEADEKNDQQSLSRAMDRTLYLLVKGKDGEWRFPQDRVYGKENLHQAAERILLQAAGVNMNTWVVGNHPVGYFMRTFPEPQITSILPNELVSTSRFPFEREEFGVKTFFMKARIMAGQADLAKNAYGDQEFAWLTREEIMQRCEFDYRYSLRGMLAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDV3</accession>
    <name>N1QDV3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="14">ENTH-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SEPMUDRAFT_150497</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the epsin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758471.1">
        <property type="nucleotide sequence ID" value="XM_016906219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QDV3"/>
    <dbReference type="STRING" id="692275.N1QDV3"/>
    <dbReference type="GeneID" id="27903356"/>
    <dbReference type="eggNOG" id="KOG2056">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012678_0_0_1"/>
    <dbReference type="OMA" id="STEFYDI"/>
    <dbReference type="OrthoDB" id="4033880at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070530">
        <property type="term" value="F:K63-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000147">
        <property type="term" value="P:actin cortical patch assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16991">
        <property type="entry name" value="ENTH_Ent1_Ent2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000010">
        <property type="entry name" value="EH domain binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013182">
        <property type="entry name" value="DUF1720"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276:SF110">
        <property type="entry name" value="EPSIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276">
        <property type="entry name" value="EPSIN/ENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08226">
        <property type="entry name" value="DUF1720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01417">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="ENTH" evidence="13">
        <location>
            <begin position="10"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="327"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="501"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="167"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="356"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="501"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="513"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="523"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="541"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMF10350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="554" mass="61494" checksum="F95C3250D67EC219" modified="2013-06-26" version="1">MSSVLRSVKNVTKGYSSVQVKVRNATSNDPWGPTGADMADVARITYNSSTDFYEVMDMLDKRLNDKGKNWRHVLKSLKVLDYCLHEGSELVVTWARKNIYIIKTLREFIHIDEDGRDVGASIRHSAKELTSLILDEERLRAERTNRGSWKSRVTGLEEFGLGGDPTPRQREQVRRRPQNDDDDLEYKLALEASKNEAELDAERRAQRSGFDTDDDLAKAIKLSKEEEELRKRQLEDQQQEDLLFDNTPDQAPQPTGFNQGYQQQAAVDWFGNPLQSQQTGYLNNAYSQPTGLQPQQTAFQNGYGYQQPQQTGWEQMQQPAQQFIQPQSTYNPWGNQMTGQQQPQQQAIQEQPTAQAGSNNPWASNNTTLSTPISAQPTGSNNPFATHTQQRQTSSPFRQPTLDTLREQQTTQQFQSRPNPIQNFSAPPPVPSPVQPQQTSRPPQDPYQAKLNSLLASGEGQDTFGNVGDMRIPAQHTAPGTYVNSAGAGSMGRLEAAKTGTNPFFSQAPTQYPAQTGPAAQFGGPGAGFGGNNPFGPRPGQPQQQSQGGSLIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1QED0</accession>
    <name>N1QED0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tetratricopeptide repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_91875</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757428.1">
        <property type="nucleotide sequence ID" value="XM_016910570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QED0"/>
    <dbReference type="STRING" id="692275.N1QED0"/>
    <dbReference type="GeneID" id="27907707"/>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002863_0_0_1"/>
    <dbReference type="OMA" id="PQACLYQ"/>
    <dbReference type="OrthoDB" id="411857at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000266">
        <property type="entry name" value="Pentatricopeptide repeat domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057585">
        <property type="entry name" value="TPR_dom_fungi"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47938:SF35">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47938">
        <property type="entry name" value="RESPIRATORY COMPLEX I CHAPERONE (CIA84), PUTATIVE (AFU_ORTHOLOGUE AFUA_2G06020)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24603">
        <property type="entry name" value="TPR_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="PPR" evidence="1">
        <location>
            <begin position="395"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Tetratricopeptide repeat" evidence="3">
        <location>
            <begin position="515"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="1">
        <location>
            <begin position="985"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="1">
        <location>
            <begin position="1020"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="192"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF09307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1279" mass="141944" checksum="9C6AE0C64AD85AB8" modified="2013-06-26" version="1">MPYVKPTVHITRLAGNAFKALSHGYAQTVVAASQTSYAAQNTSAVPLADHLIGRVFKNEKSKKQTYGVRHASTAAAAQGKAEASHDSGLDKYYEAYRDAQRNGAKKDWQQYQFARTIEWKPPAEALLHGKVQEVADIEDTTEQADFVAPTLRRSYTTSALDNFSKALLNDEAAEAAALALVNDKIAEEIAKSKEDSDADGLTIGAKSPSVASLDARDSEPRSTSPASVFTSTEGFSSAESIESDTFTEQLLELVERKRFLDVPVVFQGMLHAGVQKPSQAAYRALLSAAIEVTHEKHLKTPRALEVYSDMLKRKVVPDADTYGMLIALLSTRALEAVASRQALEQRLTRYGGLEAPGTFMFGSSQSEYSMLLEDSSLSIALKMFERARETTSALPSEACAALIIASAEQGRVEEMTRVYEYMESKSLQPQSTIYAPMITAFGDLRDLRNAVRVYDEYKALAIKNNEGENAIARLDNQVYAAVIKAYGTADRLKGGLKFLSSIQAATTNATEVEKLREVVALDALLPLALKDTTFRNAFDLTASLTGHAFIAALAKIATFAADKNLPEVCSQAFDTLAQRSQDLVEPSMAMLAMHVRNANVEAAEPFWRVLEAAPVNLSFIEPTTMRAVALIGVGQAERALRQSRRMFSRIREATTESQQADVAQSIDEAVELIGSFSLKQPMLLPATSIEVLRMMMENGSLVAPIADHLVARFGPEHIARLNQPDLEFLIRIQSRMILEEHSADIASPARFGCLLENIISHAIMPSAETETLIEKTLINIDRAELSRLWNNYRYPTTPAFPTAPFPSVVTLQPPVTSFEDTYDPYAGRTDVKGSNVINDMLERPHGRRMIEAMNRFRNMRRVGRVPRMFTYGKLIESAAKENNLNLASDILEMAKQDVPFDARYRVVRFGWQQILDNMVAACLNVGRRDLAGRYHQDMIDMGFAPSANTFGLYITTLKENTKTFDEASEAVKIFLRAKSEGVEPSSFLYNALIGKLGKARRIDDCLFYFAEMRNLGVRPTSVTYGTVVNALCRVSDEKFAEEIFEEMEACANYKPRPAPYHSMIQFFLTTKRDRSKVLSYYERMRSRGIQPTVHTYKLLIDTHATLEPINMPAAEALLEEMRTNGVQPEGVHYASLIHAKGCVLHDMEAARSLFDSVIAEGKVQPMPNMYQALFESLNANHRSAECETLLQDMARRGVDFTPYIANALIHGWTLEKNIVKAKSAFDRIPISRREPSTYEAMVRAYLAVEDRDAAKVVVREALSRGYPTAVAGKIAELVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1QEG5</accession>
    <name>N1QEG5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AMP-dependent synthetase/ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_120211</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757473.1">
        <property type="nucleotide sequence ID" value="XM_016901581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QEG5"/>
    <dbReference type="GeneID" id="27898718"/>
    <dbReference type="eggNOG" id="ENOG502SMXR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039419_1_0_1"/>
    <dbReference type="OMA" id="GNESIDM"/>
    <dbReference type="OrthoDB" id="5360374at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43845">
        <property type="entry name" value="BLR5969 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43845:SF1">
        <property type="entry name" value="BLR5969 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF09352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="431" mass="46900" checksum="CD71ADA3240C08DE" modified="2013-06-26" version="1">MDASLRSFLSFVKTASPFYAELYKEVNISDSSTTLQSLPVVPHAAYWAANTTRGNLVRTAPVTDGVVFKTGGTTSKPKATAYSQSELLRTSTQLGAGLVAAGLRPGDRVANLFYAGELWGSFLLHVLSILSTSVPAVHLPISGPAPPESYADLLEEFDVTATLSTVTSLVNLANYMLPQKRTLPLVHAVMFAGEALYPDQRVLLQQLFPNATFRSCILGSMDAGVFAESAGQEDARVHRVLQSSVELELLVSTDEPHGEVIRENGVAGDIVVTSLIRSLTPVVRYPTGDRAEWVDYQAGIFRLLGRSGTSIRLGPVSLDMQDVRRISVEAVSPVAVLGVQAVLTREAGKDCLQVSIAANREECTERLNLTDEGARDQLCRRVLERLWEERPMLPQHIAMGLIGSVRVRLVKFEELEVNVRSGKLMGVVDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>N1QF77</accession>
    <name>N1QF77_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_150500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758473.1">
        <property type="nucleotide sequence ID" value="XM_016906221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QF77"/>
    <dbReference type="STRING" id="692275.N1QF77"/>
    <dbReference type="GeneID" id="27903358"/>
    <dbReference type="eggNOG" id="ENOG502R8TW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1644459_0_0_1"/>
    <dbReference type="OMA" id="ATLYFNA"/>
    <dbReference type="OrthoDB" id="3635447at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109533" evidence="1">
        <location>
            <begin position="23"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF10352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="167" mass="18517" checksum="14C0599FEA72B90F" modified="2013-06-26" version="1">MRTATTTFLALASSLFASSAYGCLYFNATLTDTKLSVHSWDDANNNNATNAEDIICKGDDLEQMAPGQWSVPCNRADNAKSDTVFDVFLEPNTKRFMDIIYRYSNPGAEGLQLAAGGENPDEFLFNFRVASVDGSFFKSREFCGQYDILRLIKPEALKNECDSLDTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFI2</accession>
    <name>N1QFI2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_127205</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758618.1">
        <property type="nucleotide sequence ID" value="XM_016902134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QFI2"/>
    <dbReference type="STRING" id="692275.N1QFI2"/>
    <dbReference type="GeneID" id="27899271"/>
    <dbReference type="eggNOG" id="KOG0590">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_374757_0_0_1"/>
    <dbReference type="OMA" id="LACEYWI"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="399"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="51"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="204"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="91"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="127"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="206"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF10497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="741" mass="82446" checksum="D2FD9DD0CFAA8CF9" modified="2013-06-26" version="1">MATTTKFGYRRWGSNGQLACEYWISDDGTDAPATASSLKFTAGSLSHLHQAKYHPYNVRTPRRYGHQHRRRSSSTNSNSSSSSSSSNSSRSGDRNSHGRRGDRSQRDPSLLLHTAKSAGDPSSAKSTQKRLFSRRRRHHYQPSISSKSSSPSSISNPSMSLTTHVSMASSPVAEKRKSGFLNRLHHLGHNRRRSSVNELAGADVTPQPLSQQQSPPATRTSTAAARPTSRNTTPTLTTTTAAAATAIATATTTTTANEQPGNAAALRPATVNGDADTTHIAPPQIMIRAPTARHDDFEGVHYPDGLNPTPLSPSARSNKGIKWAEDCDATAPRPRRTSSAATHGRRSSIYSKDVDGNFDNVLGVELGVGSKARRLSVALPDDLQVDECSLEEHFNYLQRMKHKEIGQGGAAIVKLMQSKTAGSSSEKVYAVKEFRPRDAAEESEYEYERKIKSEFAISKACDHSNIVRTYRLCHSGDQWYHVMEYCELGDLNDLIAQGNFQRPEDRNCMFKQLVRGVDYLHSRGIAHRDLKSENLLVNKQGCLKIADFGTGEVFCGQHPGVRNCRRQSIIDPNAPTRKCQPGWVGSVPYMAPEIYQRLGKYDPRAVDVWAVAIVYVTLCFGGNPWDFAGQECKNFRIYMSHWEAFFEKYKDHEIRIGRPVPVFGHIGKFAGLDDQETRVMLMGMLHPEPAKRWKIQDVLECKPVEEAPCCQQDGYSDDIKKRQKKSLHNHIPMNMRKKVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1QG09</accession>
    <name>N1QG09_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Origin recognition complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_87942</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the origin recognition complex (ORC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ORC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760384.1">
        <property type="nucleotide sequence ID" value="XM_016910458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QG09"/>
    <dbReference type="STRING" id="692275.N1QG09"/>
    <dbReference type="GeneID" id="27907595"/>
    <dbReference type="eggNOG" id="KOG2928">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018596_2_0_1"/>
    <dbReference type="OMA" id="AHERYFF"/>
    <dbReference type="OrthoDB" id="346673at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007220">
        <property type="entry name" value="ORC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056772">
        <property type="entry name" value="RecA-like_ORC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056773">
        <property type="entry name" value="WHD_ORC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04084">
        <property type="entry name" value="RecA-like_ORC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24882">
        <property type="entry name" value="WHD_ORC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 2 RecA-like" evidence="7">
        <location>
            <begin position="232"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 2 winged-helix" evidence="8">
        <location>
            <begin position="491"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="152"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="466"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="33"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="163"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="470"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF12263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="559" mass="62334" checksum="F652AC0779716F34" modified="2013-06-26" version="1">MPKRRKRDDTTTEDDDPTPRKARRSAPDDHVPSISSPLRGSETPSRSILKQTPTKANGLQSFDATPSSLRKVLFATPNRPEEEVDDNAEETPLATRNDRNDRSARKKSQRTLQKQIAQGDDSDDGENEQDEAIAQAILGEDEDVEDGMEMEIAVAPDTPSKTGRPRGRPKGKRRERTPSPPPNLPPHELFFFQNRGGGNKTSANTMPSNLLLNHEDYFARIASYEDPHKSDIAMLKQLHVRAFNQWNFELEEGFSICLYGYGSKRSLAMDYAEHIYGQSEKPPNIVVVNGYASGLTIRDVLTTVASVIVHKGSKLPAQPAAMLDTILTTLTETPPKEPIKLIIHSLDHVNLRKAASQTLLARLAAHRSISLIATCDNPNFPLLWDISLASQYNFLFHDATTFSPYTAEIEVVEDVNTLLGRSSRRLGGKDGVGYVLKSLPENARSLFRILVAEQLALADTEGEMFLNGRPAKKPKQKKSTPSKKLSMPATSSSGGVEYRTLYHKAVEEFVCSSEVNFRTLLKEFHDHQMIESKKDALGTERLLVPFRREELEAILEDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1QG47</accession>
    <name>N1QG47_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PSI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_149993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760419.1">
        <property type="nucleotide sequence ID" value="XM_016905897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QG47"/>
    <dbReference type="STRING" id="692275.N1QG47"/>
    <dbReference type="GeneID" id="27903034"/>
    <dbReference type="eggNOG" id="ENOG502SXHK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128363_0_0_1"/>
    <dbReference type="OMA" id="CPLRSER"/>
    <dbReference type="OrthoDB" id="5427091at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF12298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="180" mass="19744" checksum="276B5265A15AD730" modified="2013-06-26" version="1">MDSRASFTTMTEIASNVTTTDRAASCWRRQDCHSCTHDKHGCGWCPFSSTCVPASSLTQPVSDKNICPLAAEKWELRTKALGCGCSTTTLLSIIVTIFATIGALIVLIALGWLLKTLNPFFGSGVVSGTELKPKEGPFYEEREWRRPGLGSKLRAWMDLKPDLSSQSEQEAITERSRLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGC8</accession>
    <name>N1QGC8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">TMEM14-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_119406</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759013.1">
        <property type="nucleotide sequence ID" value="XM_016901504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGC8"/>
    <dbReference type="GeneID" id="27898641"/>
    <dbReference type="eggNOG" id="KOG4267">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096652_3_0_1"/>
    <dbReference type="OMA" id="YGLFTFG"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1740">
        <property type="entry name" value="Transmembrane protein 14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005349">
        <property type="entry name" value="TMEM14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044890">
        <property type="entry name" value="TMEM14_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12668">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 14, 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12668:SF15">
        <property type="entry name" value="UPF0136 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G03720)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03647">
        <property type="entry name" value="Tmemb_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF10892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="127" mass="12817" checksum="765D3A4988696CEA" modified="2013-06-26" version="1">MSSSTKPTIPQTTQTTNKMSLSTLSIILGLLTSMGGITGYVRTGSIPSVTAGCTVGALYLLGGYRLSNRASYGIESALLASVVLAGSSIPRAIKGGFKPLPTGLSVLATVGLLAFGNGYMSGKGKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2023-02-22" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGD7</accession>
    <name>N1QGD7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_128231</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757724.1">
        <property type="nucleotide sequence ID" value="XM_016902202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGD7"/>
    <dbReference type="GeneID" id="27899339"/>
    <dbReference type="HOGENOM" id="CLU_3051916_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF09603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="54" mass="5741" checksum="90CDF05BC40876FD" modified="2013-06-26" version="1">MATLAHALDGLVARDTTGHCRGGRVLLGAPSLGHGYATKLFAQYYSPSDKRKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGS4</accession>
    <name>N1QGS4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_91691</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757325.1">
        <property type="nucleotide sequence ID" value="XM_016910567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGS4"/>
    <dbReference type="STRING" id="692275.N1QGS4"/>
    <dbReference type="GeneID" id="27907704"/>
    <dbReference type="eggNOG" id="ENOG502SCIW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_17_1_1"/>
    <dbReference type="OMA" id="HLPWDPI"/>
    <dbReference type="OrthoDB" id="5336600at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669">
        <property type="entry name" value="5-KETO-D-GLUCONATE 5-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G03445)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF09204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="280" mass="30061" checksum="7EBBAEA6A9A6558F" modified="2013-06-26" version="1" fragment="single">MSKAPAKKLTEEEKAAKHGALVVFGSGPGIGRNIAALFAEKGFSKIYLLSRNQERLQEDIDFVKNHAASASASASASSTPKVDGKADAETTTTSCKAIAVDLEDPGKVRAALAELDGRLHGKSLECVVFNAARVGGSKLMEWSAVNYEADLRISVVSMLMVAQWAMPQLVAAGKKEYYTPAFLVTSGGLYKNPFPAFFSLASCKAAQYNLLHSLHKEYGPKGVHCAALVVEGKVSEEAQVTTPKNIALEAWKLFEEPAPGELDATIQDPDYLEWVKKVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1QHG5</accession>
    <name>N1QHG5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nitrogen regulatory protein areA GATA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_145841</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016903297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QHG5"/>
    <dbReference type="STRING" id="692275.N1QHG5"/>
    <dbReference type="GeneID" id="27900434"/>
    <dbReference type="eggNOG" id="ENOG502QSII">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020417_0_0_1"/>
    <dbReference type="OMA" id="GVMMKRV"/>
    <dbReference type="OrthoDB" id="5563539at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007039">
        <property type="term" value="P:protein catabolic process in the vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013860">
        <property type="entry name" value="AreA_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052292">
        <property type="entry name" value="Glucose_repression_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28051">
        <property type="entry name" value="PROTEIN MTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28051:SF1">
        <property type="entry name" value="PROTEIN MTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08550">
        <property type="entry name" value="GATA_AreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitrogen regulatory protein areA GATA-like" evidence="2">
        <location>
            <begin position="188"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF16635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="598" mass="66637" checksum="383BD89A352022AB" modified="2013-06-26" version="1">MTECLSLPMQPDRSPYYQRSGSLKSSASSPSLFFDKDSSSTASPRTAYTPHAEHQETLHNHPSQWTCPLPTHSTTDSFSTISNHTVDDSVTTSSDSSVTSDTSEDTDITFPNYDGYDGDFGLPTDSSVVAETNGKCHDEPIESPANTTISESPLSTPTVVDDTAVRQEPSRQVDFLSHEWREEDIWSSWRNIVSQRKTVYGERSRLENASWRTWAKTKFDLRTVSPERLNWLKESDVTWLYGPLKVAASYPITHHSGTNSASRLSTNNSFVNKKPILKKRSMSEVMLQKSLSTSSLVKQAAASAQSQGCHWRRAGPDVIDSKLQSEIPSRDQMDYFTSHSTSGVGTPYESHEKRHIRFDDRVEQCIAVDCKYTGLDEDDDEEIEDEEAHGEHAVSDSSSDEGIVMMKRKRRATAKRRPTGSRNNSATSGRKIIETLPATTLKYRTDSPDITEEAQHHTFGRSWSTGNLSPSPSQETLRPTNPLNNFLLPTDDDAEDEIDSDSSWSFGATNPKSSLGASGSLSHREAADTRRTRRNTAAPAEQFDFQVEGMRRTPSGMFMPVDEDEDDIVAAGLFGRVSETINTARDIAHVIWNVGWRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1QI90</accession>
    <name>N1QI90_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Structure-specific endonuclease subunit SLX1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_149908</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760280.1">
        <property type="nucleotide sequence ID" value="XM_016905847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QI90"/>
    <dbReference type="STRING" id="692275.N1QI90"/>
    <dbReference type="GeneID" id="27902984"/>
    <dbReference type="eggNOG" id="KOG3005">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030739_1_0_1"/>
    <dbReference type="OMA" id="KEAKMKW"/>
    <dbReference type="OrthoDB" id="24645at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033557">
        <property type="term" value="C:Slx1-Slx4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048749">
        <property type="entry name" value="SLX1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050381">
        <property type="entry name" value="SLX1_endonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20208">
        <property type="entry name" value="STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20208:SF10">
        <property type="entry name" value="STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21202">
        <property type="entry name" value="SLX1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Structure-specific endonuclease subunit SLX1 C-terminal" evidence="2">
        <location>
            <begin position="156"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF12159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="334" mass="37758" checksum="BB30AD1CC2B80C43" modified="2013-06-26" version="1">MSLRWAWQNPQTTRHITADSRITQANMTSRISPKTGKIRTRSKRPRLSLTERLRNLHLLLRARSFRQWPLQLTFYCEDVHRVWMKLAEQITERLPSGFIVTMDEASRATKPRKQPAEDVVPADSIGIQALDVGYTSLKQHLRKSQELFGADAPTLQCCVCQSEVPSSGASTLVCSNDDCSAVSHLQCLATKFQSETELSNDLVVRSTGRCPTCSSELQWVNLAKELSLRMRGEREIKEIFKTKRVRKGTVTEAVQDHDADSSGEEGALPDIIPEDYDWPQIDDSSEEEVAPVRRLTKGVPAPKRTPRKPSKQIRTTCSEPVIEDSEWDEAEILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1QIA7</accession>
    <name>N1QIA7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL29m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">54S ribosomal protein L4, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_48990</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759029.1">
        <property type="nucleotide sequence ID" value="XM_016909091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QIA7"/>
    <dbReference type="STRING" id="692275.N1QIA7"/>
    <dbReference type="GeneID" id="27906228"/>
    <dbReference type="eggNOG" id="KOG3331">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063281_1_0_1"/>
    <dbReference type="OMA" id="YAHGRAW"/>
    <dbReference type="OrthoDB" id="270763at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038340">
        <property type="entry name" value="MRP-L47_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010729">
        <property type="entry name" value="Ribosomal_uL29_mit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21183:SF18">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL29M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21183">
        <property type="entry name" value="RIBOSOMAL PROTEIN L47, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06984">
        <property type="entry name" value="MRP-L47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF10908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="226" mass="26068" checksum="70804B4892765EDF" modified="2013-06-26" version="1">MHCTCKTLLSGVFNAPRSCAATIPPTFLAPAFAAAQTSSFSTTHTNSARKDGNKARGVSALRRTGLKKQRVSIKPFELPKPVDRERIAPVQVDDDHGLWEFFPHDQKSMANPEELGSHGRAWEIRELRHKDWECLHKLWWACIKERNRLLTYQIERERVGNMYGRYESDERTKTIRLTMGRIKFVLTERWYTWENARNEAMSDKEINLSADVDAGELAYMPKDQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2023-09-13" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1QIT2</accession>
    <name>N1QIT2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_127203</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758615.1">
        <property type="nucleotide sequence ID" value="XM_016902133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QIT2"/>
    <dbReference type="GeneID" id="27899270"/>
    <dbReference type="HOGENOM" id="CLU_2160008_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109907" description="Secreted protein" evidence="2">
        <location>
            <begin position="29"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF10494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="12218" checksum="8E3D61E63A118BA5" modified="2013-06-26" version="1">MERSIAVRALLLSARLFSLNTTTTTTTATTAPHPPTQQTRTPDLERVTNLLARPLARPNRYPPPDSELCCTRTFPTHRHSAPDKQLSGGNSTFLIIVLILGTTSERFADFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKR5</accession>
    <name>N1QKR5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_146006</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765003.1">
        <property type="nucleotide sequence ID" value="XM_016903399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QKR5"/>
    <dbReference type="STRING" id="692275.N1QKR5"/>
    <dbReference type="GeneID" id="27900536"/>
    <dbReference type="eggNOG" id="KOG1492">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048898_0_0_1"/>
    <dbReference type="OMA" id="CKRFTST"/>
    <dbReference type="OrthoDB" id="410307at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000035">
        <property type="entry name" value="CCCH zinc finger protein, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46156">
        <property type="entry name" value="CCCH ZINGC FINGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46156:SF1">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="309"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="338"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="365"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="309"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="338"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="365"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="85"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="422"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="112"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="436"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="470"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF16882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="481" mass="53219" checksum="DDE87F199D0C8714" modified="2013-06-26" version="1">MSQETQIDLQARIAALAGQINRRKQQPIPHQHAVHGGPQHGRGASRWAPYTHGARAAFPRTISNHLLVNGSGEHPILLDDETQLKTPQGAPKASAEFVRSRVGNRAQLMTKETYERERRRQQEYQQHRSPNTPYPPPSRSTGLVQETQSNAHAPRVLQFDDIKFELQLDGSKLVRLSDPATADKETPRKVNIADIEFLRTKSGNLIRAATTSQNKTRYQEPLHALKLMNSAHTISVSGPPHELRQSNATSSQNMVPYHPSSCHGAAPHRTKAIDTPYCSRHAGKFSGYMLTDCAGNCPHGPTCNDRHDPSRIAICKEFFATGFCQAGKSCDLSHEPSYHRVPACIHFLRGNCTKSACRYAHVNVPASVLVCRPFATLGYCSKGVKCGNRHVFECPDYTNLGHCAAREKRACTLPHIDHANTLRKAAKRQGKQSSEDGSDVSSDEEEQAIAAETDEDSDIEITMGTDDSHQLTQQQDYVGFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKU9</accession>
    <name>N1QKU9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_35048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765038.1">
        <property type="nucleotide sequence ID" value="XM_016908591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QKU9"/>
    <dbReference type="STRING" id="692275.N1QKU9"/>
    <dbReference type="GeneID" id="27905728"/>
    <dbReference type="eggNOG" id="ENOG502T105">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1251144_0_0_1"/>
    <dbReference type="OrthoDB" id="5425130at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF16917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="224" mass="24974" checksum="B0AE3C769A7AD337" modified="2013-06-26" version="1">MITENRTNSPPSASEPVRDFSAPDSEPNDHTTDFPCIEEPQPDPEKELLENISPTIPAPSPLPEDSPHKYGLRDSANTPPVPHATQDIQLPKARRKSSGLEIFKDGEDRRRGHNFKSSGFAYTRPLTLAQIKCYRGHAKLLLSRNRHAPVECAVCHIDDQAEHFSCSWCALRMCKYCRNDLAERGICALKERIKIAEMGNRVDSVHGSSDESLQDLGKVTSKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKW0</accession>
    <name>N1QKW0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase/reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_146812</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016766022.1">
        <property type="nucleotide sequence ID" value="XM_016903882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QKW0"/>
    <dbReference type="STRING" id="692275.N1QKW0"/>
    <dbReference type="GeneID" id="27901019"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_1"/>
    <dbReference type="OMA" id="YMTGTDF"/>
    <dbReference type="OrthoDB" id="417891at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF63">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF17901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="281" mass="29581" checksum="CB3A5934878BC29B" modified="2013-06-26" version="1">MASNTTGRLAGKNAVITGAAGGIGLETSILFLREGANVLMTDISVPALEKALAKAKECAPSAGGKVEIAKVDVSKEADIESAVAKVDAWGGVDIMFNNAGIMHADDADAVDTPEKIWDLTQNINVKGVWFGSKHAVLSLRKHQKTKGSIINTASVVALVGSATPQLAYTASKGAVAAMTRELAIVHAREGYRFNSLCPAPLNTPLLQDWLGDDQAKRHRREVHFPSGRFGEAVEQAQAVLFLASDEASFVNGHDMVVDGGMTKAYVTPEGPPTQPPVNAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>N1QL12</accession>
    <name>N1QL12_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Crh-like protein</fullName>
            <ecNumber evidence="16">3.2.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">SEPMUDRAFT_145598</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell envelope</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the glycosyl hydrolase 16 family. CRH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.-.-" evidence="16"/>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764434.1">
        <property type="nucleotide sequence ID" value="XM_016903151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QL12"/>
    <dbReference type="STRING" id="692275.N1QL12"/>
    <dbReference type="GeneID" id="27900288"/>
    <dbReference type="eggNOG" id="ENOG502QQ71">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027506_3_2_1"/>
    <dbReference type="OMA" id="DIINYNP"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02183">
        <property type="entry name" value="GH16_fungal_CRH1_transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017168">
        <property type="entry name" value="CHR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF68">
        <property type="entry name" value="GLYCOSIDASE CRH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037299">
        <property type="entry name" value="Glycosidase_CRH1_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="10 18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8 16 22" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 20" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110957" description="Crh-like protein" evidence="20">
        <location>
            <begin position="21"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="21">
        <location>
            <begin position="22"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="275"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="281"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="17">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="17">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="26"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR037299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR037299-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR037299-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EMF16313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="424" mass="43267" checksum="5DE42C15E10F4DD2" modified="2013-06-26" version="1">MHFTLSAGVALLASASFTLAQTYTDCNPTKKTCPAAVGLPSSSYSVDFTQGSAGIAPWSAASGTTLEYGSDGAVFTIAQSGQAPTIATDFYIFFGHVDVTMRASAGTGIVSSIVLQSADLDEIDWEFLGGDNTQVQSNFYGKGNTTSYDRVVYHPVATPQDTWHTYGIDWTSEKIDFSIDGTVIRTVPYASAATVDGKNFPQTPMQLKLGSWAGGDSSSEGTVEWAGGKTDYSQAPFKMYVKSVDITNYNPGCEYAYSDMSGSYQSIDVVTSGDSCKADGASNSSSTASAGNSATATTQSSAQQSSAQSSAQSSAQSSAQSSAQSSAQSSAQSAPTASQVVKPIEQTISLQTTVTGSAYSVNTASISALNSGMLPSATATRNSNDGEGASSSTSAIASSTGAASLNVAMAGGSLLSILLGAALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1QL79</accession>
    <name>N1QL79_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_146895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF18016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016766137.1">
        <property type="nucleotide sequence ID" value="XM_016903944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QL79"/>
    <dbReference type="STRING" id="692275.N1QL79"/>
    <dbReference type="GeneID" id="27901081"/>
    <dbReference type="eggNOG" id="ENOG502S0Z5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035325_0_0_1"/>
    <dbReference type="OMA" id="PGMGFYQ"/>
    <dbReference type="OrthoDB" id="4092340at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="311"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="456"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="322"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="385"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="466"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="500"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="510"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF18016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="565" mass="60854" checksum="8B21F6AB44529D25" modified="2013-06-26" version="1">MSIGTGGIAQMTYNNNNNNGFPASGLGLPGSGFSGARGQRQNTKRLSVALPPRVAPISENSIDSPTPRTSRSHLLAGLRTQPKTHAVPASAPYHQTQHSMSGANSAQWADQSYNGYGQQMPATASATGFDASSQYAKTAGRQMYSLPEQVLAPPTMYEQEDVDPDVLQQMQMHSLYLAQRQQQLQQQLANITAATQGMSLNGMGSFHQAHMTPQQQQQQAYYAQQQQQQQQLQQLQQQMQQQQQMQSPIEVPGQPGVYLVYNPAIQGYSYVVDQSVQQQAQTQAQQAQQVSPIQQAQNNHQLSHARYESPMQGFHATPPATERSSPANGRSFTPPKKAPSPPSILDHVEPLPPPSATAFRRGHKKASSLAISASGNVNEGPKTASAATFGSQRSAYPPTPMTGTFGPGAARAGEHPIRQPRGPPAIEELAAAPTSKHEGSKNFATRQRRRALDSLMKAGHERRAVSRSSGGSPVSESDFDFDQTDDGSRGSRKMSPIGSEMQQKRGSQHSSDGYFGLSSASSSEGEDAGAFKQPPTPATPVDGGNRKKMMFGVLNAAEKRKSHFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>N1QLM7</accession>
    <name>N1QLM7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_45421</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760352.1">
        <property type="nucleotide sequence ID" value="XM_016908967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QLM7"/>
    <dbReference type="GeneID" id="27906104"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_11_5_1"/>
    <dbReference type="OMA" id="AYKIPFI"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF71">
        <property type="entry name" value="ALPHA-GLUCOSIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G02650)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="295"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="40"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF12231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="539" mass="58970" checksum="2D81F6CD55E9663E" modified="2013-06-26" version="1">MDTKIVLDSALIASSKATTRREHTLTIRQALVKHRTAVLWAILFCLPNVIIGYEPTIVGTLVGVPAFRKKFGYEHPVGSGTYILAPSWISAFAYAPAIGYMLSALWSGWCVDRFGPRKTLIVAMTLSFATLLLEVLGNSAATIFVGDLLTGLLVGGCPVLGPAYISEILPVCLRGIGLSCNNLSQVLGSLIGIVVLRGTESRSDKWAYKIPFITEYAFPLIFVVGAYLAPETPWSLAKRGRFEEAKRSLQRTGYQDEVEDTLAHIKETITLESELSASTSYADCFRGTNLRRTAICAIAYSGQFFCGINLAASYCTYFFQLAGLSTDRSFDLSCGLFALGVVGNILSWPLMTIWGRRDGYIWTCSLTTLLMFIVGFLGLASDSNKGAMYGKAVGLLLFNFVYNIGLGPIVYVLIAELPSTRIRGKTLGIACFVPHAFYISITAGLPYAMDPAKAGWGAKVGFLFGGLSTLVVLWAFFYLPESKDRTFEELDVLFERKVSARNFARTDLTDFDRTEVMNGTVVVEESVVEMKHSEKSAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1QLS9</accession>
    <name>N1QLS9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_46349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760457.1">
        <property type="nucleotide sequence ID" value="XM_016908996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QLS9"/>
    <dbReference type="STRING" id="692275.N1QLS9"/>
    <dbReference type="GeneID" id="27906133"/>
    <dbReference type="eggNOG" id="ENOG502SEIT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2418981_0_0_1"/>
    <dbReference type="OrthoDB" id="4586300at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF12336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="115" mass="13293" checksum="9A7B4EDC87457F51" modified="2013-06-26" version="1">MLLEKQNDWRLSGAREEQSERALIKNPESESYPTGETMSKKPDIISTLTTTQTTRLPDGTVTTKVVLKQRFVDGREETTESFHTRNEAHSDEASQRDDKSQRDEKSTTKRGWFWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>N1QLY6</accession>
    <name>N1QLY6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_104531</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765373.1">
        <property type="nucleotide sequence ID" value="XM_016900544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QLY6"/>
    <dbReference type="GeneID" id="27897681"/>
    <dbReference type="eggNOG" id="ENOG502R0X8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_792655_0_0_1"/>
    <dbReference type="OrthoDB" id="3647306at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF17252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="350" mass="39461" checksum="71F1635127543D85" modified="2013-06-26" version="1">MASSNAGLSQRIVDSGRTLVQTAFSNLASDSAIHPPFGSKHAPSGFANSLRAIIPTDFSRNASAEGFSGESFRSASGSVRRVENEYEDFVSGFASSTSSSMTGAEIIHGWLEIGEDCQVHTGWETLPAREQPITYTHQGSLANTASTWERTSQGEVVYRPDGRPEWRWRHEWRRIDVELTQEPRVASELARFSSHLGIESRAPRCDQCSALARLHQVKQHLAFSPSSDGTNPWLQHWYAGRQGRCDWTQDDVFRSACDTSKEEPECYSFDCHQRGCHHTLLRINENLTSEIRQRLCVHDECSHISETAESWLRHITSPHHHQLQSEMLKDIKDDGQSRLLASQRESEADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1QM94</accession>
    <name>N1QM94_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_145717</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764600.1">
        <property type="nucleotide sequence ID" value="XM_016903223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QM94"/>
    <dbReference type="STRING" id="692275.N1QM94"/>
    <dbReference type="GeneID" id="27900360"/>
    <dbReference type="eggNOG" id="ENOG502SSJB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1220147_0_0_1"/>
    <dbReference type="OMA" id="VGTHEDN"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052061">
        <property type="entry name" value="PTE-AB_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260:SF1">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF16479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="274" mass="29791" checksum="0B11826684859D4C" modified="2013-06-26" version="1">MPQVGTHEDNVLIADLNKRIDEEFKVKVLRGRCLGVSKQLKGQESGWVEIVPPISAPGADGTAAGVGALLPFHDRLIDALQGAKGLGVERVFWDRDDQKLVAIVWFGGALSGWPGVTHGGLLATALVEKIALAGSLASGGDGDITSAAKPQRLPGTGKHATLQAVEAIPEEPVELSMDYMKPTFANSFYVIRVQPAWTSKDDVRLPVQGHEYFAVLETMDGKACVKATAKFAPRSELERVEESVKEAVSRWSYQDFKKWMWPSRQEETLAEAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>N1QMZ6</accession>
    <name>N1QMZ6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_78437</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPL family. K-HECT subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765918.1">
        <property type="nucleotide sequence ID" value="XM_016910196.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.N1QMZ6"/>
    <dbReference type="GeneID" id="27907333"/>
    <dbReference type="eggNOG" id="KOG0168">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0170">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000366_1_1_1"/>
    <dbReference type="OMA" id="AEPLSQF"/>
    <dbReference type="OrthoDB" id="423283at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045322">
        <property type="entry name" value="HECTD1/TRIP12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057948">
        <property type="entry name" value="TPR_TRIP12_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HECTD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25579">
        <property type="entry name" value="TPR_TRIP12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="8">
        <location>
            <begin position="1588"/>
            <end position="1944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="795"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1143"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1277"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1387"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="32"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="120"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="173"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="253"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="795"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="818"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="832"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="854"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1143"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1194"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1393"/>
            <end position="1410"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="1911"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF17797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1944" mass="212732" checksum="B5370A482FBB5C4D" modified="2013-06-26" version="1">MSMNNTTESATHSITSQRVTRSATARLHADLDSIAAANTTTTTNPDSSTTANTASASHSDTSLAAAIAQQSPSAAALDTPSTRATPAPRKRKAPADSTPPIAREQRKTKRPRGSQHPDTTEPLTEPDTAPAAAEAEAAPKRGKRAVAAVMSSTGSAAPPRASHRGRADMDRPNSGSSADTSPQQVPRDSSRRKSSRRKSKEESTPTGSAAPSRKSRKGSRKDQDVLMKDVDDKAAEPSQGLEQDEQSRLDADMGADRADHQSHPERAFSAQDAQDQLDALDRGEDPFATGYLSRFGGHSGLSNSLRALSGMVSSTHNRLRNILEQLRTKEDPSVQMIALQELSELLLISNEDNLAGHFAPDQYVKELVTLMQPNDFTGEENPEIMLLACRCIANMMEALPASTASVVYGGAVPVLCQKLLEINFIDLAEQALSTLEKISVEFPSSIVREGGLTACLTYLDFFPTSTQRTAVVTAANCCRNIPEESFPTVRDVMPILLNTLTSNDQRVVEQASLCVSRVVDSFKYHDSKLEELVSADLLKAILRLLLPGSTNMIGPSIHTQFLRVLSTTARVSARLSVELLKMDVVDTLYQILTGVSPPVGMEGVATKIDKNIIMQAIIRTPREQIFETLNVICEILPTVSQESLMFLDDLQDAGYTGPENASMSTRSKTVPNDKRVELLKGCPNEVKRFAIILFPTLMHAYTSTVNLAVRQKVLTAQLKMLSNLDTVILEEALRGVPFTSHLASIFSQQDNASLVTFALQAAELLLKRLESVYRPQFYREGVIAEIAKLAERSLKTPSNADVTSHPTDEVPAPETEEPEHNEPSHEFGAEPEPIEGEVDDDDGEDEDRGQPPEPNDDDDDEDEDEEEEEAEETERRIARELSLDSMPSPRPLQLVDLQDVITLRAKRFIAAHGEGGSDEMRLKATQVLDDIKQLAEQLKSCYTTPVRGNGPSLFKRLATYFDGDALESITSYELMTSGVVAVLLSMFNNQDEQAAANARADFLEVFMAEKNGRALHADVEAPSTPFGALVHKLQELLSRAEHFEVITVHHNAFESNKGSAASMLAKQLRLKLVADEDSGIPRAYRNIMVSIHAIATFKALDEYLQPRISMSERPRGARRSDMSSAMAAYAAAMASRGDRGLHPLPALPALGSSSLPTSSAGKRATRKVKTEPVPLSESSKVEESASKLRRSSRRQSAQAPSASAPAAATPVPPPERHSQEGLECADEAHISDDDDDDDDELEADLDALVDDLEEGALERDEPDPSAVSLEVANSGKVTARTEDGARVSTPSQGAPTPTGFDRMSAAARLAAARELLSDPSGSMRAALNYPSAPQTPRQDWHIVFTVNGQPIASDTTIYRACHFNQVQGEDVSSRNIWSAMHTISFKKVPGPAPKDRDAETPPSISDDRSSSNDLPPSLSEHPVTAEILRLMSILHELNAHIDDVLPESKAAFKVAAQPVSLFVNAKLTAKLNRQLEEPLIVASQCLPSWSEDLARLYPFLFPFETRHLFVQSTSFGYSRLMSRWQTGQENESARHRDERPFLGRIQRQKVRISRSRILESAIKVMELYGSSSSVLEVEYFEEVGTGLGPTLEFYSTVSKEFSKKKTKLWRENESADGDEFAFGKRGLFPAPMSEETARNENGQRVLHLFKMLGKFVARSMLDSRIIDVSFNPTFFRIGDASTTVTPSLGAVAAVDADLAKSLKMLRQFVTAKQRIDDNPNLTPAQKAQKAEQIRVNDAKIDDLALDFTLPGHASIELLPNGATINVTIENIAEYIKKVIDFTLGAGVQRQVDAFRAGFSQVFPYSALKAFTPDELVMLFGRVDEDWSLETLMDSIKADHGFNLDSKSVRNLLQVMSEFPPQSKRDFLQFVTGSPKLPIGGFKSLTPMFTVVCKPAEPPHGSDDFLPSVMTCVNYLKMPDYSTLEVLQKRLGTAIREGQGAFHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1QN19</accession>
    <name>N1QN19_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">adenosine deaminase</fullName>
            <ecNumber evidence="4">3.5.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_146099</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>adenosine + H2O + H(+) = inosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:24408"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.4" evidence="4"/>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765105.1">
        <property type="nucleotide sequence ID" value="XM_016903455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QN19"/>
    <dbReference type="STRING" id="692275.N1QN19"/>
    <dbReference type="GeneID" id="27900592"/>
    <dbReference type="eggNOG" id="KOG1097">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022829_1_0_1"/>
    <dbReference type="OMA" id="YQPRQTM"/>
    <dbReference type="OrthoDB" id="7202371at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006154">
        <property type="term" value="P:adenosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046103">
        <property type="term" value="P:inosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000017">
        <property type="entry name" value="Adenosine deaminase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409:SF37">
        <property type="entry name" value="ADENOSINE DEAMINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="10">
        <location>
            <begin position="283"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF16984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="597" mass="68511" checksum="2E51E3EF1B3BFB44" modified="2013-06-26" version="1">MEEASDAIDIAKSVLEHHIKRLQDSTTYQKQRQELLHDERKVAWDEPARRSASETEVLANAILIAIREHERYDSNLFGNRPGEAIPGKHTRDMGGRFLVNKDRIDQSRTLDIARHMPKGAHLHLHFNAELPAEVLLPHARSAAVENTMFIRSTKPLLALADFDDCEIAFDVLPRDTGAGDIFSAGYDPEHRRRRIDTTTAWMLWRDFRRGFPQDVYIENSASSNDAGLDRAEQWVRDKMILTRSKAYADPRTTNGVWACFNQGTRAFKGLVNYEAVYRWYIGAAIDSMIRDKVMYAELRPMLLDRDIPANDGVHRLDHVQQMTIICEELKKKEIELRAAHQLHLFPFGIKIIYCTPRSIPRERMQQELEKCLNLKLKFPHLICGFDLVGAEDRPNHIAFYADQLLAFTASCKELQITIPFLFHAGESLLDTGGSHDPENSNLYDALLLHAKRIGHGYAILKHPTLVQQYRERQICLELCPTSNELLGLCENIREHCFSELLAAGLHCTLNADNPSLFRGPTLDTKSLTYEFYQVLVGDPTMNLHGWKQLALWSMQHSCLDDDQRAQLQRTFEREWAGFCQWVVDTYSEFCQTLPGWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNC5</accession>
    <name>N1QNC5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_32593</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765280.1">
        <property type="nucleotide sequence ID" value="XM_016908502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNC5"/>
    <dbReference type="STRING" id="692275.N1QNC5"/>
    <dbReference type="GeneID" id="27905639"/>
    <dbReference type="eggNOG" id="ENOG502SPDA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087975_0_0_1"/>
    <dbReference type="OMA" id="EMWEVLA"/>
    <dbReference type="OrthoDB" id="4151352at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="13"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF17159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="258" mass="29044" checksum="380776750B3BFCCE" modified="2013-06-26" version="1">MPSLAPYPEAPQPPQKVAAIWSSSDDEILLQARASGLNWQPIANRYFPNKSANACRKRHERLVERRHGDDWDTHKLELLAAEYMACRKEMWEVLAARVGERWLVVEAKCMEKGFKTLQTTARLAQRKASAAYQPKEDRWVIPDHHSDSGIGFGSDAELDVAPGTSSREAVSWHARRAGREQTQLQSHQEHVRSRSLPQPLPLYQPPPPIPRTFEGRTTTKLPREPSPLPTPTVSAPRQRRSLDQNGRGGISIQSVLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNE5</accession>
    <name>N1QNE5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Glucose-6-phosphate 1-epimerase</fullName>
            <ecNumber evidence="3 5">5.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_104905</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the interconversion between the alpha and beta anomers from at least three hexose 6-phosphate sugars (Glc6P, Gal6P, and Man6P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:16249"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58247"/>
            <dbReference type="EC" id="5.1.3.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glucose-6-phosphate 1-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.15" evidence="3 5"/>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765809.1">
        <property type="nucleotide sequence ID" value="XM_016900556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNE5"/>
    <dbReference type="STRING" id="692275.N1QNE5"/>
    <dbReference type="GeneID" id="27897693"/>
    <dbReference type="eggNOG" id="KOG1594">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048345_1_0_1"/>
    <dbReference type="OMA" id="TQALHSY"/>
    <dbReference type="OrthoDB" id="1659429at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047938">
        <property type="term" value="F:glucose-6-phosphate 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09020">
        <property type="entry name" value="D-hex-6-P-epi_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025532">
        <property type="entry name" value="G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11122">
        <property type="entry name" value="APOSPORY-ASSOCIATED PROTEIN C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11122:SF13">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016020">
        <property type="entry name" value="PHexose_mutarotase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR016020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR016020-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR016020-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF17688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="322" mass="34866" checksum="44B8EDC13DF5FFCE" modified="2013-06-26" version="1">MDRPHKPSALLSPASTGPQASVYAENGKVTATLPTGDSVEILLFGATVTSWKSNGKERLWLSTAAKLDGSKPVRGGIPVVFPCFGPPPQNHATSALPQHGFARNTRWEYMGKSSTESSVLMSKNASRGGDDNGVKVDFGLSSDSLSEEAKKAWPFKFSLVYSVTLGKDGLQTMLQVRNEGKEAFDFQMLLHSYFKVADISKTQITGLGSVTYIDKVLNATEHQQTSPNLSITGEVDRVYKSIKQPTTSIVEDGKPSLDVTRDGGVEDSVVWNPWVEKSKSMGDFEPKDGYQTMVCVEVGAVDGWKTLESGETWEGGQVLVAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M3AR43</accession>
    <name>M3AR43_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_54909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF07924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756045.1">
        <property type="nucleotide sequence ID" value="XM_016909319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AR43"/>
    <dbReference type="GeneID" id="27906456"/>
    <dbReference type="HOGENOM" id="CLU_2948364_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF07924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="55" mass="6452" checksum="6C42AAE17A7E3AE1" modified="2013-05-01" version="1" fragment="single">QRVEYLIDLTKLFAAAIAVIRTTKGPTIYLVLIYYNKLFDILEEAIKRLKNKRIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M3AS51</accession>
    <name>M3AS51_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_152028</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756460.1">
        <property type="nucleotide sequence ID" value="XM_016907200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AS51"/>
    <dbReference type="GeneID" id="27904337"/>
    <dbReference type="eggNOG" id="ENOG502RN1R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025401_0_0_1"/>
    <dbReference type="OMA" id="CSTFFAA"/>
    <dbReference type="OrthoDB" id="10062838at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026505">
        <property type="entry name" value="Solute_c_fam_35_mem_F3/F4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19346">
        <property type="entry name" value="SUGAR PHOSPHATE TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19346:SF4">
        <property type="entry name" value="SUGAR PHOSPHATE TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="74"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF08339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="321" mass="34818" checksum="CB705173584C7E88" modified="2013-05-01" version="1">MYLTHSALALPWIAHMLYMRYTNRQISYVQWVREYNNTLRGSIATIDAFATHGSKMVIKGPGRTGGPLDFLATSMAIVTIILTISGFSWFTSLSLTTPADLTAIYNCSTFFAAAFSVPILKEKLGWISILAVALSIAGTFTIAYGDTTADHSSESDPAIGGSRLLGNVIACVGAVAFGLYEVLFKKWACSNRPESQESSLPLTLAASALTGFYTFGVLWIFLIIFHILGIETFSFPSAYAWLWLVIAVLSGVIGITLLVVLVIWTDPVFGSMANVLSVFFVALADWLVWDLTPSLATYIGGGCIFVAFGMLSYDTLGEKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M3AVC9</accession>
    <name>M3AVC9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_50101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758127.1">
        <property type="nucleotide sequence ID" value="XM_016909148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AVC9"/>
    <dbReference type="STRING" id="692275.M3AVC9"/>
    <dbReference type="GeneID" id="27906285"/>
    <dbReference type="eggNOG" id="KOG1269">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057148_1_0_1"/>
    <dbReference type="OMA" id="LSFGTWC"/>
    <dbReference type="OrthoDB" id="10017101at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="47"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF10006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="282" mass="31210" checksum="60D572AA7C50F9F6" modified="2013-05-01" version="1">MASTTRGSNPYIPGHKPKHIANHTWRTAENSSAYVLPTLKEKVLKNPQIQALDCAAGPGTITASLAKYFPQGHIIATDLSPEIVAQAAEYARSIGVTNVSAQVASIYDLPFESDKFDFVHAGQILCHLDQPLKALKEMIRVCKPGGIVAVRESDVRMFNVWPEVKGLMDTLELWKRVMEASGGSYNMGVRLLSLALEAGIERSAIQASMGTWSYSTPEEREIWGGTIAVRLREGNMRNLIVEHKLGWTLEQLDAMADDWDKWIETEDGWFGAMNGEIIITKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M3AWW0</accession>
    <name>M3AWW0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">O-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_126793</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759331.1">
        <property type="nucleotide sequence ID" value="XM_016902102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AWW0"/>
    <dbReference type="STRING" id="692275.M3AWW0"/>
    <dbReference type="GeneID" id="27899239"/>
    <dbReference type="eggNOG" id="ENOG502SMXA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060397_2_0_1"/>
    <dbReference type="OMA" id="FMGQPVR"/>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861:SF1">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="3">
        <location>
            <begin position="47"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF11210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="229" mass="25518" checksum="9D57FE4181BF9E7F" modified="2013-05-01" version="1">MDDPKQINEQAYDHLADWYLDWANSQESPRQRYTDKVLQNARPHPHILELGCGPGIPITKMLLDRGASVIGNDISRTQIRMATSRCPEAAFIAGDMATLEFAPETFDGITCFYAIFHLPREEQKAMLAKIFSWLKPGCMLVFNTATIDSAEIHGEMMGHGMFWSSYDVEGNTAMVTAAGFEGVEAEVIEAGEGKLEESDPDYGVSFLWISALKMKKKKKKRKGTDDSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M3AX68</accession>
    <name>M3AX68_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RabGAP/TBC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_150284</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759436.1">
        <property type="nucleotide sequence ID" value="XM_016906066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AX68"/>
    <dbReference type="STRING" id="692275.M3AX68"/>
    <dbReference type="GeneID" id="27903203"/>
    <dbReference type="eggNOG" id="KOG2058">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005350_3_2_1"/>
    <dbReference type="OMA" id="ETFHILL"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="504"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="596"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF11315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="890" mass="98750" checksum="09C5C36E06CC2877" modified="2013-05-01" version="1">MPSHMVEDQQRAWQPEHTLSVAEALQEAMDDGAAYDRPEQPRTMGSFSPRDMPAPEPHLPLRKSSAANRMQARKGPIPKPIFAPTHHHQVQGFGPSPVQPVPCIDQVQASSVHAFSKEQRVPYRPAMAVLESQQQVLPYTKDLPQLPPDAAQIRYRSPSSPVQSLSTDHADSPASSSIRKRAKSLKHTKVAGDGLRNIRNRISGRARAGQSHSSPGILTPDTHSSSKASPAVPDNEVRDSFRSALTSHSSFGNASSVLTTQTTHTSLSSTTDNDFVRIRTTDYDEGGLTDLDMSVDDVLGMYEDGFESGTGSLRPSPRPSMQSATRPSLDARPGSARPAQVAARTSADRRSVKSLDRPHSQPRASTLAPERPNAAHRRSHSASILIVGVKRASLRGISPALPLAAAQPGIEESSAEQIVPAQSLGSRPPTVEPDVPPRDRYGFKKVSHYVTARMYDDWNKDYSQYLERRRKKWYAMMHQYGYETEPAIRFPQKSEKVKRYVRKGIPPEFRGAAWWYYARGPRELAKNPFIYRELTDRVDNGALTDNDREHIERDLHRTFPDNVRFKPDPTTMHDAQAGAGGGTTTKEGSNLKDETLATSADTSETGSPESAAKKKNKKRHTDEPETPILQSLRRVLQAFAVHRPEVGYCQSLNFIAGLLLLFLSKDDSDLEEAETKAFILLNIVTTQHLPSTHGVSLEGANIDIGVLMSCIRDSLPAIWNKLDDQKELNAIGAAATMAGGVGGLRLPTVSLATTAWFMSLFVGTLPIESVLRVWDCLFLDGSKTLFRIALAIFKHSEDQILRVSDPMEIFQVVQSEPRKMLDINTLMDCCYKRRAGFASISQDIVERRRRERRQIMQEGMMKQGLAAKSDDMVRRMRTRLRTRGGMRVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M3AZX5</accession>
    <name>M3AZX5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Isochorismatase hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_132455</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761203.1">
        <property type="nucleotide sequence ID" value="XM_016902496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AZX5"/>
    <dbReference type="STRING" id="692275.M3AZX5"/>
    <dbReference type="GeneID" id="27899633"/>
    <dbReference type="eggNOG" id="ENOG502RXWW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068979_5_1_1"/>
    <dbReference type="OMA" id="TGMMTHM"/>
    <dbReference type="OrthoDB" id="245563at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540:SF15">
        <property type="entry name" value="BLR5631 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
        <property type="entry name" value="PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="22"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF13082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="197" mass="21220" checksum="43B2DDE3F2483EE4" modified="2013-05-01" version="1" fragment="single">MALSARQMLNLPPSTASPSNSTLIIIDAQNEYAQGALRVTNASSTRKVISQLLELYRSASSSSATRIVHVLHQVPDGAPIFTPGTDLAEEFEELRPQEGEKVVKKLHPSAFAETELDGLLKKDGVEGKKVVLVGYMAHVCVSTTARDAARLGYDVLVVEDGVGDRDIPGATGEEVTKMVMHELGDFFATIVQSQDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M3B2C6</accession>
    <name>M3B2C6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_42030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762023.1">
        <property type="nucleotide sequence ID" value="XM_016908855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B2C6"/>
    <dbReference type="STRING" id="692275.M3B2C6"/>
    <dbReference type="GeneID" id="27905992"/>
    <dbReference type="eggNOG" id="ENOG502SQUP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053359_1_3_1"/>
    <dbReference type="OMA" id="TESNIRH"/>
    <dbReference type="OrthoDB" id="199599at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052053">
        <property type="entry name" value="IM_YidH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187:SF1">
        <property type="entry name" value="DUF202 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187">
        <property type="entry name" value="FGR18P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="7">
        <location>
            <begin position="121"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF13902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="239" mass="26814" checksum="8446BFEF852A5B50" modified="2013-05-01" version="1">MGTSDDPQPSSPSSSPAQQYHHPSFTSDPNTATAGSIRQIHNTEAQQIPEPEAAHIPDGIPEHEREATELQQQPRHRSDVQRPLSRVLSPSLASEHIYFITPLKSFWRHHVRLSVPHVDCRDHLANERTFLGYLRTSVAFSMIGVFIAQLWRLQHSPTPDPTFGYYVLSIPVSIIFQCAALVMVLLGAVRYWRQQEAMAVGRVWAGGWEMGVIAVGSLLLLTLLFVLHLALDVKHTYLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M3B3B6</accession>
    <name>M3B3B6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_148053</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762408.1">
        <property type="nucleotide sequence ID" value="XM_016904669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B3B6"/>
    <dbReference type="STRING" id="692275.M3B3B6"/>
    <dbReference type="GeneID" id="27901806"/>
    <dbReference type="eggNOG" id="KOG4169">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_13_2_1"/>
    <dbReference type="OMA" id="RCDVRNW"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229:SF4">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="191"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="191"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF14287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="234" mass="25983" checksum="222B2C75BA4C2BA7" modified="2013-05-01" version="1">MHFQQCDVSHWQSLHDLISSSVNTFGDVPDVYVPSAGLFEPPSSNFWDDTEVDSYKTIQINVNHPIKFTRLAMRALAGAEKQGVVCLLSSTAGLGGHYLANLYTASKHAVLGFAKSMGQADVDEGVKIICVLPGLVQTPLWEDREDDPAAWEQYLKMLKSGLQPEDIANLMLKMIESREYEGGTCVLKVTKGEEHTQEEGFSKKAAKSNSDPKPEPDLKRIQSLMRAERGKKWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M3B411</accession>
    <name>M3B411_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_148202</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762628.1">
        <property type="nucleotide sequence ID" value="XM_016904771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B411"/>
    <dbReference type="STRING" id="692275.M3B411"/>
    <dbReference type="GeneID" id="27901908"/>
    <dbReference type="eggNOG" id="ENOG502SNKW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013866_5_1_1"/>
    <dbReference type="OMA" id="SAGCENC"/>
    <dbReference type="OrthoDB" id="2991872at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="83"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF14507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="653" mass="72841" checksum="D61C9D93B2FB9B8D" modified="2013-05-01" version="1">MVYRGKPSAGCENCRKAKKKCSLGSPCLRCIKLKKACGGYRDVSQLQIQDESAAVILKANKQGPRASGSSKSPVAAPVVRATSLHGKSTPETPGSSTATSEISLPPSSAADSLSHKRSRPTLVDLDATEAVEINAPGGTFLTFTMKPTPEDLGSNYFFSNFTSDNGHWSVLRNYEKRAELNPLLGFAMKACGLAALDNVHGVQMGRSYSRMLYAQALTLLNKALRDPRQCKSDESLIAVAMLGYFENITCDSKESIASWKAHIQGATQLLKLRGKAQFNSAFGRMLFRENRAQFLIRCIWDDLEPPAFLIDWEDDLRRLSDELQWIGPADELTMLTFEFAQLRYELRVRKVSYNDAIATASDIEMRMSQWAAELMKTNPFWQYRQVEVPDSPEVWNGQCHIYNGHPTASVWGTYRNVRIMVTRTQEFLIRRLALSPEQKERQLSYLKSVRRQMTDEICMGIPSQLGHGPTNNSKHILITAYSSIWPLFFAGTCALERIGPGLWSTALQDMTPSQEASTSAALAQAMWIIGRMEHISRIVGLKWAEGVAATLRGDFAMHEELLPEGGPPHGAHVPMFWLERMAEMRRNREPGWLKKVQEGGPGPRVTMEENAPLSTGLMAGAYPKGLWKGRVQVDEKTKKYRNNSMNISSIINP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M3B622</accession>
    <name>M3B622_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase family 125 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_59898</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763388.1">
        <property type="nucleotide sequence ID" value="XM_016909508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B622"/>
    <dbReference type="STRING" id="692275.M3B622"/>
    <dbReference type="GeneID" id="27906645"/>
    <dbReference type="eggNOG" id="ENOG502QR7D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023537_2_1_1"/>
    <dbReference type="OrthoDB" id="7771656at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008313">
        <property type="entry name" value="GH125"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31047:SF1">
        <property type="entry name" value="DUF1237 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31047">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 157 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06824">
        <property type="entry name" value="Glyco_hydro_125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01149">
        <property type="entry name" value="DUF1237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032089" evidence="3">
        <location>
            <begin position="25"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="629"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="661"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="581"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF15267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="683" mass="75868" checksum="001EF079A67127DE" modified="2013-05-01" version="1">MVKLNSWRTLTLLAAVSAVQGVAQWDNTLFEDQVNCPKYGDYTDHWHGPSSGGIHNMSSMRPEPRCRSFKSAVVEATIANVTASIADVDLKRLFENTFPNTLDTTVSWRGVSENNTEEELAFIITGDIDAMWLRDSANQLQSYAALLTASNSHDDALPSLFRGAINLQARYLLAAPYCNAFQAPAEQGRDRVENGAHNGQKIRPEYDWNMVFECKYELDSLAAFLQLSSTYFEKTGDLEFFRKFSWLSATEMVLNVAQNMTDHPTYNDNGTTAEQPYTYSRVSNHGIGNPVAAGTGLVRSFFRPSDDPTIYQLLIPSNMMFSQFTGLAANIADQLGNQTLAKRMQEMSASIRAAITEHGITHTKQHGPVYAFEVDGYGSANVMDDSNSPSLLSSAFFGYHNITDPIYQNTRARALSIYNPYWAHGSHISAVGGPHNGPGKAWPLASIMRILTSDDDEEISQQLRQLVSSTDQKGLMHESVNSHNSSRWSRSWFAWANGMFGECILDLKERKPHLLQLSFQDVQVDSHDDRGHVDYTPLMNGSDGSLGIANSTVTSSLETSGPDAEATPPPPPSLSTTADSQAKHEDEQSPNHNHEEEEAKPMSNHDHAHGAAPAEHHAPIHIEESKMTWFWFMTGFLAACSLLIVVLSSWRRRRRRSPSLIKNNQDHSDDGEEEGVPLTELHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M3B6S3</accession>
    <name>M3B6S3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carbohydrate-binding module family 63 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_147372</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763623.1">
        <property type="nucleotide sequence ID" value="XM_016904255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B6S3"/>
    <dbReference type="STRING" id="692275.M3B6S3"/>
    <dbReference type="GeneID" id="27901392"/>
    <dbReference type="eggNOG" id="ENOG502S9P9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026963_3_1_1"/>
    <dbReference type="OMA" id="DYNHFVS"/>
    <dbReference type="OrthoDB" id="406505at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22272">
        <property type="entry name" value="DPBB_EXLX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.760">
        <property type="entry name" value="Expansin, cellulose-binding-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007112">
        <property type="entry name" value="Expansin/allergen_DPBB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036749">
        <property type="entry name" value="Expansin_CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049818">
        <property type="entry name" value="Expansin_EXLX1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009009">
        <property type="entry name" value="RlpA-like_DPBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041144">
        <property type="entry name" value="expansin_EXLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF21">
        <property type="entry name" value="EXPANSIN-LIKE PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03330">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49590">
        <property type="entry name" value="PHL pollen allergen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50842">
        <property type="entry name" value="EXPANSIN_EG45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004031859" evidence="2">
        <location>
            <begin position="17"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Expansin-like EG45" evidence="3">
        <location>
            <begin position="31"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF15502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="215" mass="22852" checksum="DB8A67DAD6D7D88B" modified="2013-05-01" version="1">MFSILAMLAAAGTVVASNSGQATFYGGNTQGGMCSFSTYTIPSGIYGTAMSSRNWDGSETCGGCIEVTGPNGKKITVMVVDQCPECELNHLDLFQDAFAELADVSKGIIDVTWEYVDCPITTPLQVHMKEGVSRYWFSAQIVNANKRVASMEYSTDGGSSWKSGLTRQPYNYFELSSGTGTDTVAIRAESVDGDRVVVKGVSVTGGNLVKGPANF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M3B7G5</accession>
    <name>M3B7G5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_39329</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763933.1">
        <property type="nucleotide sequence ID" value="XM_016908742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B7G5"/>
    <dbReference type="STRING" id="692275.M3B7G5"/>
    <dbReference type="GeneID" id="27905879"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_27_0_1"/>
    <dbReference type="OMA" id="FHWAFER"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF15812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="520" mass="58701" checksum="6DC167F6499E0BC6" modified="2013-05-01" version="1">MIADNVGSVLLTAATIAILLRIISNAVRKFKQSSKARALGCQPASIEPAQWPLGIDTIRNMMKADREQRTPDFMVERFNRMGRYTFLVQVLGQSNILTADPENIKAILATQFADFRMGRVRETNLKLVLGRSIFTVDGDAWHSSREMVRPIFSRENVSDLALLERHLKVMFKCMPVNSDGWTKPVSLATLFPCLTIDSATELFLGKSTNSLDARLAGRDGGKDFHWAFERVQQILGIRIRLQGLYWLYGNREIKEIVQILNDFCDRAMDEADYKNRQADGKNYDYLDVLRSRAADPSEVREQVLGLLAAGRDTTASFLSWVFYCLIRNDRVFHKLRRIILDTFGPDGFDEANITFEKLKGCSYLQHVMNETLRLHSIVPFNGRTAIRDTTLPTGGGPDGTAPIFIPAGGEVRFSTHVLHRRHDLWGPDADDFVPERWEKKRPGWSYAPFNGGPRICIGQQFALTEAGHVIVRMLQKFDAIEGLDVDPLRDYHNFTLVCGPGPGHEGVLCRLRDATARKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M3B7N8</accession>
    <name>M3B7N8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zygote-specific protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_114931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">SO2202</strain>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR37475:SF1">
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            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
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        <location>
            <begin position="21"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF15867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="82" mass="8011" checksum="5D4B6653FAAAFF35" modified="2013-05-01" version="1">MRFTTLTLATLATLILPSLAGPAAYGICQAGCSAVVMACYAAGGATWGAALGATAPPTIVACNTAYGICYAACHAAIFAPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
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                <person name="Zhong S."/>
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            </authorList>
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        <source>
            <strain evidence="1 2">SO2202</strain>
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    </reference>
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            <dbReference type="EMBL" id="EMF07918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="767" mass="88073" checksum="C2BA9D5F99E0DCF9" modified="2013-05-01" version="1">MAMEQPQPINYDERIRTQVPQGELFRQYEPFQNLEALVEAPFVGPRPLGVTQITPGRHRRDGITVSMIQDSIVLPQYPQTDQAGYAYCINIGGIPREGARMPENLPIQHQYAARRKPGYPKDTTCIYLGGIRATRYKWTCSGIKYCEYFDPTIATAPHTRVGHEYWENQGRTRQYIDPTEPNILIRNSKATIAAAWDRLKKGIACRPQNDTCRLEWEWCERAADGDGSRNGFLKCRNRPPNGALVDDQPEVHFREAVWQNQQKNVELFPELLQELYDREAEGEGDIPPATCTIHENVATRLKHCGVLHSNTTRGRLIRAGCNVVFNLIVPQNLDNPNHRYVIFTSHGIHSHLPPIPNRTPKEFAESVRTVVRQAQDGSVSNSSFLRSGFLKSFFSIQGVDSLEAIHPSFANKSRIRAMLYYEKLLLYPEGTHFAGVDFELARQGLDPATQYIRGAWNRENESAQVICFHKLQAEWFLNVGMFEIDMNFKRIRQRDMNELIFGALIETEGSVCPFARIYMEGEDAESYCLAFQRLFESLSQVTARVVRWRHHSPGGNGEGFQGVAMDMGAGQIKGFGLYLQSVDPEGRHWEWQVKNICVYCRIHLRRSIENVEGVGFRTERGKRMMDILLAQTQESYDAILEEVSGFSTRHANWANHKRQDVIRSGLCHAYAQMPQYIYKRLRNHTNAVEQLHNKTYWSGLYCDLLVAIFQSRAADSSTIRTFYTHALFGVRADDRSNDSVARKSRDMGRKRKLFNELIQFLTNRFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M3BQ56</accession>
    <name>M3BQ56_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_159218</name>
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    <organism evidence="2 3">
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            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756404.1">
        <property type="nucleotide sequence ID" value="XM_016907829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BQ56"/>
    <dbReference type="GeneID" id="27904966"/>
    <dbReference type="HOGENOM" id="CLU_1836399_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF08283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="140" mass="15627" checksum="23B013CBAC424290" modified="2013-05-01" version="1">MDYSIELHRHTREQQASKSTVAGAQHGSTVGEGTRHHKRWEQQLDRMKTDLGGRGRVQTMAEEDTGGRVTAARAAAGEDGVLLSQTEPPMPPKILKRREQHLKRMREALGSPALRFVEEEGGEDQKQHPVYTLCACCVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M3BR25</accession>
    <name>M3BR25_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_152198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
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        <lineage>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016907297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BR25"/>
    <dbReference type="STRING" id="692275.M3BR25"/>
    <dbReference type="GeneID" id="27904434"/>
    <dbReference type="eggNOG" id="ENOG502SJYB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_615642_0_0_1"/>
    <dbReference type="OrthoDB" id="5336565at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
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            <begin position="67"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="111"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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            <begin position="428"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF08573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="445" mass="48475" checksum="1B92532A1F32F007" modified="2013-05-01" version="1">MPSLSPAPPVLEDPSCKRQRDNDDDDGDANDPPRARKRARARARRRTRLTPEALRRLSRDTVRSEQRTVQWVQSEAFGSSRGQAKKARKATAALGISSSATSHRRSRRSSKTSQSTRTNSIDSASSIHDASAAQILRDHQIYGPAKRCAPANLVELQEKMRRPRASVSPSRVDEATWERYCRAYYAAKNEDAVTANFMQHFPGNAPYETIQNTAFRKMASLTPSARLPPVKPDIAAGLPPEDIDIKIRREIGAYVLTTNGDTPALVNSFTELKGPRGKEKAGLEQAAYDGAAGARAMHKMRSFGLSAEPEPDGNARTFVTSYMQGTTAFYASHMQPPGRGATTGSYHTYPLGGEFSLGSAAQFRASITSYRNLQDIAASERQAALQLAHAQSVAQQGPNTQDPAAASSVRQARQASSSTKRARRVESSSDDDSYASANEDECNDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M3BSR5</accession>
    <name>M3BSR5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_151949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF09133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757254.1">
        <property type="nucleotide sequence ID" value="XM_016907145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BSR5"/>
    <dbReference type="STRING" id="692275.M3BSR5"/>
    <dbReference type="GeneID" id="27904282"/>
    <dbReference type="eggNOG" id="ENOG502S1K8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_389383_0_0_1"/>
    <dbReference type="OMA" id="GNEQGWM"/>
    <dbReference type="OrthoDB" id="5389734at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="601"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="795"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="403"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="608"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="623"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="634"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="644"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="676"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="708"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="754"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="830" mass="92777" checksum="9F1C8EA5F99668ED" modified="2013-05-01" version="1">MKRDPKSAPAARIRDSTPSCRRVSHPGCGGEMAAHYHQVSVTDGVNERCSEQHEFRQLSSRPRGDDDEQKENAWDDDLDMAPPVHPIPQMQAAFEESIRDAIAPIDHRDADADADHDHDEASGTPAAMRRRRLLEAEHDGAAAAAVTRWKQKPGAKHHPFVKLMAQVVFGMHLLKEGQAKSNEEVVLILQGHIDDVDCFLERTAADFDLAIKDIEERIRYLKLPMQHMDVFDTMLDDKKFRTELLNGNEKIEKIIERTAHAMNAAMHDIHMGIRSTKELNTYLTRIERRWSPENRNIAEVFAAMRGNEQGWMTYLRDLRTKGDNLRNNLVVLETVIGEIARHAAAASRRNKFQGRQVSGGPPGSVQNGKSPPPRSKYTRDTPSPYHYKPPGAWLDKPLPQEPNAVANVKQAAVAKPHPVSLDSRFEQPRGAVTAPQRRESVKPTASLDTSEARGASSTREPPIGDAPEGTSSSTQELSNFLRNSGGLRSHPPDVVRDGRTASHHPARSHSQGGAFPPSSLDKHFRRSRSQNTVAMSEPRAPSRTESRTEPLSQSRWARPESKQSHPSRTQSRDDGSITSMLKYQMPLTRDAFSRHISKRLKNIPTPLSSRSQRQSSAPAPSTVFRSTTNTARHSPTRHQKHMHHQSEDIHDHGNEERMKHGTDRRRSAKPERMVVEEEEEEEEEEEEQEEEEEEADNEAEEEDEEEVKEAPLRSESRAGGHSLFPPNVDRPLTPLQAVARNNSHGSADGKGFISSSSDSSPQTQHTRTTTVTTATTSNSSNFVKTNRIVGLSRKLFGSSGGGSGHHHQQQQHHFYDRRGPVNGRGNIMVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M3BTP2</accession>
    <name>M3BTP2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_151070</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758121.1">
        <property type="nucleotide sequence ID" value="XM_016906576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BTP2"/>
    <dbReference type="STRING" id="692275.M3BTP2"/>
    <dbReference type="GeneID" id="27903713"/>
    <dbReference type="eggNOG" id="KOG0298">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001592_0_0_1"/>
    <dbReference type="OMA" id="AHQINEW"/>
    <dbReference type="OrthoDB" id="5330228at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052583">
        <property type="entry name" value="ATP-helicase/E3_Ub-Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059033">
        <property type="entry name" value="C144_05_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45865:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SHPRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45865">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SHPRH FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26021">
        <property type="entry name" value="Ferritin_C144_05"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="538"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="126"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="591"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="605"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF10000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="882" mass="98901" checksum="FB6D120E9602AE37" modified="2013-05-01" version="1">MCEEVGLNQYGVPSFDDWNPDDPATVETMRSWLVRLRQTCLHPQVGVRNRQGLGRNKAPLRTVAEVLELMIEQNGLALRMEERARAQAILRRGHILGNNREDDHRAEKACEVYRLAMSASEQMVEDARQKLAAAEATDPRSALLSDDNGSEDSSSDSMPLLGRLRSNLRLALQLMHQCSFFLATAHYQIKTNKALTAEGSESFQQLEAEEARLYETAKLARKEILKDTHRKADALMVQVKAIPSKGNAFTKLKDLPSFGGIESRRIAEKSDSLFEVMRESVGMIKEWRSKIAEFLLQPLVDEDHGIETTGDEYEDSTKVQEELYTYIDALKAIHADLNFLVAGETSPLIDHEIKTQLKGAIFNLDPENAETEWFQSVIGREKIVVKLFSSRMKVRDRQNEVGSVRGLIQEARTLESSLDGKSSGRTETELSLVKQHITHLQAVHTSYSKAVTALEKEIELFRSAQNQRLDFYRHLQELSDDVSPYKEELDEELDLQAFDLSLAREEEATASVAQLHTKTRFLISLRNDSSGQSGPRTCSICIAEFERGVLTVCGHHFCKDCLAHWMLQRPSCPMCKHRLSKNDVHEITFKPREMRAQEEIQSGESSTSRSPDKPSSARPQQSIYTDVDSNLLEQINKIDLPASYGTKIDTIGRHLHWIRQNDPGTKSVVFSQYREFLDVLATALSAFKIGFARLGRSGSIERFRKDASVECLLLDAKTDSSGLTLVNATHVFICEPLIQTAVELQAIARVHRIGQTRATTVWMYLINDTVEEAIYEISVARRLAHVQSRQQQSRHGQKSRAGTPAEQLTEHAFDAANSDELQSAALSKLLANGNSGGELVSNDDLWQCLFGKASGNKMVIAERTASRHLRASAAEARATLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M3BWB7</accession>
    <name>M3BWB7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sodium/hydrogen exchanger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_65353</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760482.1">
        <property type="nucleotide sequence ID" value="XM_016909715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BWB7"/>
    <dbReference type="GeneID" id="27906852"/>
    <dbReference type="eggNOG" id="ENOG502QWRB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024407_2_1_1"/>
    <dbReference type="OMA" id="IPFLELW"/>
    <dbReference type="OrthoDB" id="1288932at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
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        <property type="entry name" value="NAPA-TYPE SODIUM/HYDROGEN ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43562:SF2">
        <property type="entry name" value="SODIUM-HYDROGEN ANTIPORTER"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0050">Antiport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="104"/>
            <end position="125"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <end position="159"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="212"/>
            <end position="231"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="252"/>
            <end position="284"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="441"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="10">
        <location>
            <begin position="37"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="483"/>
            <end position="503"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF12361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="503" mass="54399" checksum="E61FBC45A40AE587" modified="2013-05-01" version="1">MSDSGGSESNGRFLQYEEPGIVDILIIISFFTFLWVSGYISKKIIRAGIIGPILVGIIYGTPLANILEHIWQETFIYLGYIGLILIIFEGGLSTRLDLLRANLTLSVVGATTGVILPIGLSYLLLYLGYGYGAVETFIIGASLSATSLGTTFAVISGAAASVDLSQTRVGAILVSAAVLDDVSGLVMSSVIHDLGSIGSGGGVNLGWLIGRPIVASILMTILTPVLSKWVLAPAFRKFIEPYFHRFDHLFNIVFMILILSAFISIAAYAGTSILFGAFLAGVFLTYLPSQTPDGPFVVMSREEGEREKDKSPTFVHTFEYYCLDFQVYILEPLFFASIGFATPFLDLWTGAAIWRGLLYTLLMLIAKFLVGIWIPVWAYSLGPKVDKSKPNAETADSRSRITRMKGGVYPGLLLGMAMVARGEIGLLIVEIGYNNTTYVSQAGFLTAIWAIMLNTILGPIAVGILVKYKADDIAQGDWGLVKAPGTSSPNDEDHLRSESQTFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M3BYN2</accession>
    <name>M3BYN2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_148551</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016904993.1"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="F:GTP binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:GTPase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902775">
        <property type="term" value="P:mitochondrial large ribosomal subunit assembly"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mitochondrial GTPase 1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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    </dbReference>
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        <property type="entry name" value="GTP-bd"/>
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        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
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        <property type="entry name" value="GTPase_MTG1"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR45782:SF4">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1"/>
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    </dbReference>
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        <property type="entry name" value="MMR_HSR1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
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            <begin position="137"/>
            <end position="213"/>
        </location>
    </feature>
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        <location>
            <begin position="315"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="143"/>
            <end position="148"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>GTP</name>
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        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR006230-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF13176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="344" mass="38116" checksum="13093F4CD2556C24" modified="2013-05-01" version="1">MGSPFVPRVVFPTLESLPRSYYLGHHAAGLAKMKTMLSQIDHIIECRDYRIPLTSRNPMFEDSLAGRERMVVYTKKDLGGSKGTVEDTKRHQLIREWHEPSKVIFSNHKDRKDVRRILDVIKDANRSRGGLTGSYLMVVGMPNVGKSSLLNALRREGVNKGKVAHTGAQPGVTRKIGTGVKIIEADETGLSGVYMLDTPGVFMPYVPDSEAMLKLALCGSVKDTVVPPFNLADYLLFHINLHDPTVYKEYSQPTNDAMQLLDAVARKTGRLMKGGEPDLESIALWMIQKWRNGHLGAFTLDEVSEAALERYRNNVPTSSLSQAKKAGKKAASERAKARRAGNGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M3BZM6</accession>
    <name>M3BZM6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Thioesterase/thiol ester dehydrase-isomerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_42951</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761627.1">
        <property type="nucleotide sequence ID" value="XM_016908881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BZM6"/>
    <dbReference type="STRING" id="692275.M3BZM6"/>
    <dbReference type="GeneID" id="27906018"/>
    <dbReference type="eggNOG" id="ENOG502S4UX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050730_0_0_1"/>
    <dbReference type="OMA" id="TLPTAYK"/>
    <dbReference type="OrthoDB" id="2532955at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049450">
        <property type="entry name" value="ACOT8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052389">
        <property type="entry name" value="Sec_Metab_Biosynth-Assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38110">
        <property type="entry name" value="CHROMOSOME 23, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38110:SF1">
        <property type="entry name" value="THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20789">
        <property type="entry name" value="4HBT_3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase-like N-terminal HotDog" evidence="1">
        <location>
            <begin position="46"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA thioesterase-like C-terminal" evidence="2">
        <location>
            <begin position="202"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF13506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="373" mass="41790" checksum="8240A51BAAB2055A" modified="2013-05-01" version="1">MPPDTLRFVRRDGVRGKELFTFDEVAVVKIVDSHTYDANIHVEFSHGPSAHGGFIVAILWKVIQTHFSNTLAKQNQHNTFSLHTEFLRPCSTGPITIKIRDVRIGKATSTVHASLSQKGIENAVCYATNCGPLAVRNTISIPMSYQLTPLPPPIDFAAVLSGQDKYWIRYDVGRDPKTPNHALCNAIFAIERQTPILQDSSNPMHKRITTQWLTPRLPHETWTQPMLGLVMDHAVPPIENFYTHNAPHNNLNMPLRAVENETRGLSSYDHPAWASPRYYPTVSMTIEVKRPLAPEGVKWLMLRWHTRECVDGRFDIEAEVWDPEGRLVATAVSLWYVIDVADAGVGQQGGTGSSRKKIAEGKGIRAKYGDSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M3C2Y5</accession>
    <name>M3C2Y5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_148291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762757.1">
        <property type="nucleotide sequence ID" value="XM_016904828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C2Y5"/>
    <dbReference type="GeneID" id="27901965"/>
    <dbReference type="eggNOG" id="ENOG502QW68">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009650_0_0_1"/>
    <dbReference type="OMA" id="SGHYYEF"/>
    <dbReference type="OrthoDB" id="3353407at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021822">
        <property type="entry name" value="DUF3405"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36205">
        <property type="entry name" value="CHROMOSOME 19, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36205:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11885">
        <property type="entry name" value="DUF3405"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF14636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="712" mass="82965" checksum="F376FD6333307AC4" modified="2013-05-01" version="1">MRPAPRLRTWNPFRLLSKNSFVYQQIPSLSADSLNAVAREWPQGGIPWRDGKRRRCGVGRISFTRTLFLAVAALFAIVLLGGGGYHQRRKWQLDRERNPDVPFEWMHYSRLNGFYNGVRTLVPYSEWIPENSWNKSAPNTYVSPEDLGRQRLSAEPPMDPVKFDPYREHQIQTCFLDEEERTQVPDVYAYPGIPQHMAKPFYGDYETLGLDDGVCFERYGRYGPYGMGYNETMGGLGPGVNAEHAGSDKVWQKMGFVNYTNVDWGKAQERCVKKNADRFAVNPTTLTRKSGRQAYVLRTWTGFEYGPNQMYALRAMISELNLKSGGEYDVHFLVHVKDNGIPIWADPLVYQATLEANVPKEFWGLATLWSEKQMEMYYPEPFPDNFANMAGSSIHGVYRSAHFALQWFSQQHPEYDHFWNWEMDMRYSGHYYQFNEKVAEWAKKQPRKGLWERNMRFYVPQYHGSWQNFTEFVEAEIEHVDKPKNNVEQSGPIPVWGPVRDFPNGGMLDPPDNVTPLITYDMDKYDWGIGEDADLLTFNPIFDPSQTNWVFSWDVTGYRRDMPPPPRRSAIVTVSRLSKRLLKIMHEETWRMRHTMFPEMWPPSVALHHGLKAVYVPHPVYFDRDWDLEHMVQVFNYPTNTWDSPFGWGEHNMLGSSFYYNSGFSGALWRRWLGQHENGEGGRKQEEEGTGRMCLQGTLHHPIKHENAPEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M3C5M0</accession>
    <name>M3C5M0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribonuclease Z</fullName>
            <ecNumber evidence="4">3.1.26.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SEPMUDRAFT_147411</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.</text>
            <dbReference type="EC" id="3.1.26.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase Z family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.11" evidence="4"/>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763687.1">
        <property type="nucleotide sequence ID" value="XM_016904285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C5M0"/>
    <dbReference type="STRING" id="692275.M3C5M0"/>
    <dbReference type="GeneID" id="27901422"/>
    <dbReference type="eggNOG" id="KOG2121">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006220_0_0_1"/>
    <dbReference type="OMA" id="MSHCKHT"/>
    <dbReference type="OrthoDB" id="527344at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990180">
        <property type="term" value="P:mitochondrial tRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07718">
        <property type="entry name" value="RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047151">
        <property type="entry name" value="RNZ2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027794">
        <property type="entry name" value="tRNase_Z_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553:SF49">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13691">
        <property type="entry name" value="Lactamase_B_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNase Z endonuclease" evidence="13">
        <location>
            <begin position="6"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="12">
        <location>
            <begin position="610"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="910"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="983"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="187"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="990"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1006"/>
            <end position="1022"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMF15566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1022" mass="112785" checksum="721BCECA1BEFB45C" modified="2013-05-01" version="1">MRSFVQILTTPTADTPGTTLLLHFDNRRYLIGSLAEGTQRACVEIGAKLLKVSECFLTGRTEWTNTGGMIGMILTLADSSASSAAASLEDAKRKARIRAKIGITDSPEKIRELEEQAKKEVNSALTIFGPPNLNHTMATARRFVFRKGMPIKIHEIRDNGLPKQAPQDDDWKPFWADEHVKVWSMSVPPTSDTPQRPSASISPLKRSFDDMRAGDDGNVVQVNDDLTQEDRDYLTVKAVVGEMFNSSWRLDTLHETPLSQVKLPATIFIRDRRTNKIQKYTGPLPNDPKNPIPNANLTVLVRKPWPGALVTDLPQTKPAKEAISYIFRTHMQRGKFLPEKAKARGVTQVKDFARLTKGESVMNDRGELVAPEEVMNPPRVGGGIAVMDIPGPEYIENLVSRPEWQEPKVMEGVGAVIWLCGKDVATDVRLHAFMKEHSHLEHIVSSPDYCPNNIAFNSVAGSTIRLRRVDPARYVVPVHDGEGQQSSQPYGGTARYLETRASHPLPEKVHIAARGQKVQLEPALEFQAADTIACLDVEAAAAETPEEVIQEADKAKQSIKTLDTETMEWLNTLPPDADQAEITTLGTGSALPSKYRNVSSTLVRVPKWGNILLDAGENSLGQLKRVFAPAELSEVLRDLRMVFISHMHADHQLGTTSIIKAWYQEVHSSRPAGPVSQSATWNEILAGRDRLAVVTEPAMQQWLYEYSFIEDYGYSRLAPLSLHPAQDVRKGHKSRLIWHIPPAQLRNLSPREYEDKFDKHNVPVSALQLKDLQAVAVKHCHAARAVSITTPSGFKVSYSGDCRPSEAFAEIGKGSTVCIHEATFDDELQGDAQAKRHSTTSEALTIAQKMNARACVLTHFSQRYQKVPVFERSEGEVGDVLPTNSAADVLADDEATHAEDEMSGPLEDAAFTFPDQATGNDDPGQQYELPSKYAGSKPEAVKFKLQSDMKVAIAFDYMRLKVGDIWQMERFTPALLKLFEEESRETAAAGDGGGGGRGGGGVNAKGKGKKKQKGKAKSQRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M3C855</accession>
    <name>M3C855_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">37S ribosomal protein Rsm22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_152365</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Mitochondrial ribosome (mitoribosome) assembly factor. Binds at the interface of the head and body domains of the mitochondrial small ribosomal subunit (mt-SSU), occluding the mRNA channel and preventing compaction of the head domain towards the body. Probable inactive methyltransferase: retains the characteristic folding and ability to bind S-adenosyl-L-methionine, but it probably lost its methyltransferase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF08075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756196.1">
        <property type="nucleotide sequence ID" value="XM_016907401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C855"/>
    <dbReference type="STRING" id="692275.M3C855"/>
    <dbReference type="GeneID" id="27904538"/>
    <dbReference type="eggNOG" id="KOG2539">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007075_0_0_1"/>
    <dbReference type="OMA" id="RTSHEAN"/>
    <dbReference type="OrthoDB" id="421327at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052571">
        <property type="entry name" value="Mt_RNA_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015324">
        <property type="entry name" value="Ribosomal_Rsm22-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13184">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13184:SF5">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09243">
        <property type="entry name" value="Rsm22"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="838"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="841"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="878"/>
            <end position="889"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF08075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="889" mass="98026" checksum="7E4D30BF41B3D805" modified="2013-05-01" version="1">MWLASKAVRSSCTTCRLRGMIRGMEMARSRRTISATWSMKTLSLMRSVKSNEQKRGFSQRTSHEANASGFTRQQEVELIETLYTRGHISRDEWRDSVFMQSGLRAEGVSIEELAGDNAKLEARVRTLREYYGVAVVPQQLLESDEIKVHERLFGELRQVEAIDEEASDMGQLVGRSGTSVLGQDGEELEFDENEALEEEEDALAAENMPFGHIQGQSRPERLRHGNERLADDMRAAFDPSASSEALAQQDSVLADEAAVYQRTHPLTVEGRFATSPSTLEMPKAPYLDPVTGMLAGISNRHLIDTALRVFGGPGLPYSTATPTRGKLMPQKAIALDAYQPQMSEIEGDVYLSTLYPGVYASVMSVMVETRKRLGSAWAEGLVRKAEAGELRILDAGGGGAGVIAVREVIRAEWERMLGKSEDDLNGSTALAEADGKVGGSGVSPPLGHATVLTSSDALRNRASKLLEQTTFVPRLPDYLHAESAPAQGKFDIVVAPHTLWQLREDYIRKSHVQNLWSLLSTDGGVLILLEKGVPRGFEMVAGARDLLLEQRISSPGSEHRLTNLEEKLPNSGRNYEHIVWDDGESAEAQAEARAEAIAAEGPDLATQPKETGMIIAPCTNHEGCPMYMQKGHVKGRRDICAFEQRYHRPAFLQNVYGTQGRNHEDVEFSYISVMRGRDLRASAEATDPEDSQLPRPELVQNQTATDNAFAGYEHHTPSSSSAPPHSLSLPRVILPPLKRQGHVIIDLCTPTGTLERWTVPRSFSKQAFRDARKLNWGDLWALGAKTRVPRNVKAKPRNLGDMDVKLAKKEKKKLHQIVNQGVPDVAVDEFGRIVSNYSRDSGGGKGRGAMGGKARTGAQVRGIRDKRDKTGMGNGRRKNVERWPADDDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M3CBI3</accession>
    <name>M3CBI3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_150929</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF09787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757908.1">
        <property type="nucleotide sequence ID" value="XM_016906481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CBI3"/>
    <dbReference type="STRING" id="692275.M3CBI3"/>
    <dbReference type="GeneID" id="27903618"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_19_3_1"/>
    <dbReference type="OMA" id="HEPLDTW"/>
    <dbReference type="OrthoDB" id="1878542at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000115">
        <property type="entry name" value="Salicylate hydroxylase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF147">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G01950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="10"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF09787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="450" mass="49301" checksum="6562D1280E360FED" modified="2013-05-01" version="1">MAPVDVLDLHIVILGAGMGGLATALACAQKGFRNIDVYESASNLGFVGAGIQLAPNMARILDRLGVWADIEKDAVDLKETSIRQGSTDEELGHVDLKYVRATYQYPHMVGHRSSLAGSLYEGCQREKAIKFHFRTQATEVKAWGPQPSFLATPREGEPVEVSCDVLLASDGVKSVVRDQMLRLLKIDAKIVDTGQAAYRIMLTREQMKDDPELMQLIDSEGVTRWIGEKRHIIAYPVSGKQIYNLSTVQPDKHFASAPSASYTTKGSKPEMMHVFDDFCPKVKRMLDLVPDGEVCEWKLRVHEPLPTWVHEQVALVGDACHPTLPHLAQGAAQAIEDGAVLSIVLAKLSTTAKGGVTPEAIHKALKVYEHVRRERAYQLVDLAAASGKALHLGDGAAKEQRDKQFAALKAAGGKGGVPDKWADADVQKMIYGRDVMRIAEEEFEAVYAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>M3CET4</accession>
    <name>M3CET4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Serine/threonine-protein kinase TOR</fullName>
            <ecNumber evidence="16">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">SEPMUDRAFT_150457</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associates with DNA double-strand breaks.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Vacuole membrane</location>
            <topology evidence="13">Peripheral membrane protein</topology>
            <orientation evidence="13">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="16"/>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759677.1">
        <property type="nucleotide sequence ID" value="XM_016906188.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.M3CET4"/>
    <dbReference type="GeneID" id="27903325"/>
    <dbReference type="eggNOG" id="KOG0891">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000178_7_1_1"/>
    <dbReference type="OMA" id="MRQHSAK"/>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016242">
        <property type="term" value="P:negative regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905356">
        <property type="term" value="P:regulation of snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05169">
        <property type="entry name" value="PIKKc_TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000020">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.150:FF:000001">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000371">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000006">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.150">
        <property type="entry name" value="FKBP12-rapamycin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009076">
        <property type="entry name" value="FRB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036738">
        <property type="entry name" value="FRB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057564">
        <property type="entry name" value="HEAT_ATR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024585">
        <property type="entry name" value="mTOR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026683">
        <property type="entry name" value="TOR_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057978">
        <property type="entry name" value="TPR_DAAF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF9">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08771">
        <property type="entry name" value="FRB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23593">
        <property type="entry name" value="HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11865">
        <property type="entry name" value="mTOR_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25757">
        <property type="entry name" value="TPR_DNAAF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01346">
        <property type="entry name" value="DUF3385"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01345">
        <property type="entry name" value="Rapamycin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47212">
        <property type="entry name" value="FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9 16 21" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 16" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="FAT" evidence="19">
        <location>
            <begin position="1251"/>
            <end position="1854"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="18">
        <location>
            <begin position="2028"/>
            <end position="2351"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="20">
        <location>
            <begin position="2413"/>
            <end position="2445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="2304"/>
            <end position="2339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="2304"/>
            <end position="2317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU364109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EMF11556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="2445" mass="276018" checksum="64A0FB0FA67D9CAA" modified="2013-05-01" version="1">MTTAYSETLSAIFQDLKSRSEKIRQAAAARLIEQVTAAFRELQPTVWNAYYNEVNVKMVGFILSGQDTHERIGGLYALNALIDFKGDDAASKVTKFSNYIKRTLEGNDTSAMIVAAKCLGRLAIPGGALTAELVEAEVKHALEWLTSERNENRRFAAVLIMRELAKNSSTLLYMYVPGILTSIWEGLRDQKVVIRETAAEVVSQCFKILNARDLQMRTSCMTRMYEEAQLGLRRGTVENVHGSLLVFKELLVQGGMYMQGAKYKYVCDTILLQQYREHKDPTVRRTVVEIIPLLAAYAPKEFCLHYLARSMQHLQNLLKDARQRNLAFAAIGKIAHAVGSQIAPYLDTILLHIRDALSVKNRTRHSDEAPIFECISMISIAVGQTLSKYMEALLDPIFACGLSDALTQALVDMAHYIPPVKQTIQEKLLDLLSRTLCGQPFQTLGHPTQGKGLPPIYTKDYRDQRDPQHQEHKDQEIALALHTLGSFDFSGHVLNEFVRDVAIRYVEDDDPAIRKAAALTCCQLFVKDPIVHQTSHHAIQVVSDVIEKLLTVGVADPVADIRRTVLISLDARFDRHLAKAENVRTLFICLNDEKFAIREAAMTIIGRLTSVNPAYVFPSLRKVLIQLLTEIEYSNSANNKRESAQLISHLVGASNKLIKPYVDPMVHVLLPKAEDANPEVAATTLRALGDLASVGGEEMKKYIPELMKIIIRSLQDLASPKKREAALCTLGQLASNSGYVIQPYTDHPDLLTILVNIVKSEPPGDLRRETIRLMGILGALDPYKHQQVMEESPESNLKADYQGISDVTLIMNGCTPSNEDYYPTVVIHTLMDMLKEDTLKQYHSAVVEAVMNIYATMGMKCVPFLGVVVPGIVGILKDAATENRLEGYFSQLGILVRIVKQHIRPHLPVILAAISDYWHRNTQLQATILSLVESIARSLEGEFKVYLANVLPLMLGVLDADGRSEAGRAAMQRVLHAFLVFGSSAEEYMHLIIPVIVRMFDSADGRYKDRAVRKAAIETIGRLSKQVNISEFAAKIVHPLARVLTGNDQLLKPVAMETLCAIIFQLGQDFLHFVPTIDKIMAQHRISNTAYTLIITKLKKHEALPQDLSPDERYNDEDVDQYPAEISSKKLAVNQQHLKNAWEASQKSTKEDWIEWMRRFSVELLRESPQQALRACTNLAGIYPSLARTLFNSAFVSCWTELYDQYQEELVRAIESALTSSNIPPEILQILLNLAEFMEHDDKALPIDVRTLGMYAGKCHAFAKALHYKELEFNAEQNSSAVEALISINNQLQQTDAAFGILKKAQGYNDVDLKETWYEKLQRWDEALMAYQEREEKELQTRDMASFEVVMGKMRCLHALGEWDTLSQIAYDRWHSANGDDKRRIAPLAAAAAWGMGQWEIMDEYLGAMKVSTPDRSFFGAILSIHRNHFEEAHIHITKARDGLDTELSALLAESYTRAYDVIVRVQMLAELEEIILYKQSSHDTEKQERMRLTWTKRLRGNQRQVEVWQRMLKVRALVISPQENQEMYIKFASICRKAQRPGLAEKSLNSLLNFSSSQHLSTLADGENAESWSVVQQAPYPVQYATFKYLWSNDQHDAALHALRGFTQTLKDDYEGRMAAAAPHLAVHHPGILNGVNGVNGVNGIHSTGPFGAANAHPISHKEKAELDEWRLLLARCYLKQGDWQVKLHNGDWQSEHVADVLSSYHAATRYHESWYKAWHAWALANFEVVTSLTSGDREATDVPSYIVTEHVVPAIKGFFKSIALSSTSSLQDTLRLLTLWFAHGNHQEVTHAVTQGISLVSIDTWLEVIPQLIARINQPNRLVKEGIHNLLVDIGRAHPQALVYPLTVSMKSDAVGRSRSAKRIMDAMQQHSPTLVEQAGLVSHELIRIAVLWHEQWHEGLEEASRLYFGDHNIQGMLATLDPLHEMLRKGPETLREISFIQSFGRDLNEARDWCDAYKSTKEIGDLNQAWDLYYGVFKRIARQLPQLMSLELQYVSPELKAAHDLDLAVPGTYAVGKPVVRIQSFEPVATVISSKQRPRKLSIKGSDGVKYDFIIKGHEDIRQDERVMQLFGLVNTLLQTDTECLKRHLNIQRYSATPLSTQTGIMGWVPNSDTLHVLIREYRESRKILLNIEHRIMLQMAPDYDNLTLMQKVEVFGYALDNTTGQDLYRVLWLKSKSSEAWLDRRTNYTRSLAVMSMVGYILGLGDRHPSNLMLDRITGKIVHIDFGDCFEVAMHREKYPERVPFRLTRMLTFAMEVSNIEGSYRTTCEHVMRLLRSNKESLMAVLEAFIHDPLLTWRLGTQNSPPEPTSTLIGSERRPGALHNENGAPQLPHGGAAERNYRRASIMGGDPNAPGGVSSFRPNRQRQGSIGQGFGAQDPMEKEVQNARALQVLARVKEKLTGRDFKKEQELSIEEQVDRLLEEATNLENLCQHYIGWCSFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M3CHQ3</accession>
    <name>M3CHQ3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Non-structural maintenance of chromosomes element 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_148662</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the SMC5-SMC6 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NSE4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761439.1">
        <property type="nucleotide sequence ID" value="XM_016905065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CHQ3"/>
    <dbReference type="STRING" id="692275.M3CHQ3"/>
    <dbReference type="GeneID" id="27902202"/>
    <dbReference type="eggNOG" id="KOG2866">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041037_4_0_1"/>
    <dbReference type="OMA" id="FMGINRT"/>
    <dbReference type="OrthoDB" id="361242at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027786">
        <property type="entry name" value="Nse4/EID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014854">
        <property type="entry name" value="Nse4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029225">
        <property type="entry name" value="Nse4_Nse3-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16140">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16140:SF0">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15412">
        <property type="entry name" value="Nse4-Nse3_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08743">
        <property type="entry name" value="Nse4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nse4/EID protein Nse3/MAGE-binding" evidence="11">
        <location>
            <begin position="159"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Non-structural maintenance of chromosome element 4 C-terminal" evidence="10">
        <location>
            <begin position="366"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="215"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="231"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF15412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF13318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="470" mass="52926" checksum="DD372F20B35A0886" modified="2013-05-01" version="1">MARLNTRPSSVRGSRAATSVSPSPTPEQENRDPATRRDKGKGRASTASRTSLPTPTSDTSGASTGQKRKRARTQAGATQEADIPEDQDPDDAKFTRYYDPNQNADQRRQVKRKSRAMIRELHENRDELMRGNGDGLKAKLDEANQNFKRVKQTADATMDARLLVDLSAMAKTRAASMILGDTSAGLDVDMFLSRCVYYMKHLHAYGLAEDEADFQATQRQTQTQRRRRDHDEEEEDDDDNPEDLSWEVLGRYACFPYNSRPACPSFLLGPLSVEKKVRVQTQRRARQTQNTGPAKSVERIHKEDMSAADPNALTTQCNAIYKHLQSHCTKARKAAERIEAEEGPMDEDRIAAFCREYKVTKNASPSLFEYVINPDSFGQTVENLFYVSFLIKEGNAGVQKDEQGLPTLVPSQARSVEQQRAEKTTKNQSIFSLDYATWEKLVEAFDITESMIPHRNEDQPTQVTGNGWYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M3CIM4</accession>
    <name>M3CIM4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">5-formyltetrahydrofolate cyclo-ligase</fullName>
            <ecNumber evidence="5">6.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_125385</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP = (6R)-5,10-methenyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10488"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.2" evidence="5"/>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761784.1">
        <property type="nucleotide sequence ID" value="XM_016901977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CIM4"/>
    <dbReference type="STRING" id="692275.M3CIM4"/>
    <dbReference type="GeneID" id="27899114"/>
    <dbReference type="eggNOG" id="KOG3093">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066245_2_1_1"/>
    <dbReference type="OMA" id="DKWGIPT"/>
    <dbReference type="OrthoDB" id="2015992at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030272">
        <property type="term" value="F:5-formyltetrahydrofolate cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009396">
        <property type="term" value="P:folic acid-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407:SF1">
        <property type="entry name" value="5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407">
        <property type="entry name" value="ATPASE INHIBITOR/5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006806">
        <property type="entry name" value="FTHF_cligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="9"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="174"/>
            <end position="182"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00036539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF13663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="202" mass="22873" checksum="29B276B11D373076" modified="2013-05-01" version="1">MSSSSRDLKKQLRSQMKERLAALSEQQVMAQSRIAQNLILSSPRFQSARRIGIYLSMPHGEAQTDSLVVHALWNQKSVFVPYIYAVGAEKPKRKVMDMMRIESLEEYGELERDSWGIPKLKQAGIDERENAMGWKGLSFRPDGELAHGDEGNDDAGGLDVIIVPAVSFDQRLNRMGHGAGFYDRFLTTHFGDASRERPYLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M3CJ49</accession>
    <name>M3CJ49_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_116835</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761944.1">
        <property type="nucleotide sequence ID" value="XM_016901290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CJ49"/>
    <dbReference type="STRING" id="692275.M3CJ49"/>
    <dbReference type="GeneID" id="27898427"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="OMA" id="VGWVEPV"/>
    <dbReference type="OrthoDB" id="417891at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF4">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF13823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="272" mass="28702" checksum="E91CE67268C51172" modified="2013-05-01" version="1">MASSIAAKFSLKGRSYVVTGGAMGIGFSIAKDIAESGGNVAVIDLRDSPLEDVYGLAKQFNVKVYYFQADVSNEASLTTAFEKAVQSLGKIDGLVTAAGIAIDKPFVDQTWSEVSKVLEVNSLGSFFAAQLFVKHLQLQRTGGSIVFIASITAHINLPGYRMSGYNVSKGGIKILSQVLSSELAPLNIRVNSVSPAFIETNQTRGARENTTQACGELMQTAPPLGRIGVPEEVSPAVVFLLSEAAAYVTGADLLVSGGIHTGRGGDYDMCRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M3CQ67</accession>
    <name>M3CQ67_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_131454</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763969.1">
        <property type="nucleotide sequence ID" value="XM_016902424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CQ67"/>
    <dbReference type="GeneID" id="27899561"/>
    <dbReference type="HOGENOM" id="CLU_1210449_0_0_1"/>
    <dbReference type="OrthoDB" id="5411141at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF15848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="229" mass="25756" checksum="C7B09B12D99CE56D" modified="2013-05-01" version="1">MLATKLRSNAAVRGRYRVAKRSFLHIARSQRGSGTGTLWFLEDCWDSGESHTTRQLSSQAVILHFAQQMMALDVTEVECVSCWAWSPHVPLIEFVDVPGASSAKRASKMCQADLCASHKHSHLHGHGSMSMRICQRRHMDTFYRAQLERIQYTETILYSEGIWLGHVPMQTIMFAARHRRLRPPCPQATMSAGHETPRELAFGVVHCAGGRLEHISPVWSLCLSVDGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M3CVH3</accession>
    <name>M3CVH3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome c oxidase subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cytochrome c oxidase polypeptide VIa</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_152420</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the cytochrome c oxidase subunit 6A family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF08152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756273.1">
        <property type="nucleotide sequence ID" value="XM_016907436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CVH3"/>
    <dbReference type="STRING" id="692275.M3CVH3"/>
    <dbReference type="GeneID" id="27904573"/>
    <dbReference type="eggNOG" id="KOG3469">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122515_0_0_1"/>
    <dbReference type="OMA" id="KLPWMVD"/>
    <dbReference type="OrthoDB" id="5947505at2759"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097250">
        <property type="term" value="P:mitochondrial respirasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00925">
        <property type="entry name" value="Cyt_c_Oxidase_VIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.95.10:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit 6A, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.95.10">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001349">
        <property type="entry name" value="Cyt_c_oxidase_su6a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018507">
        <property type="entry name" value="Cyt_c_oxidase_su6a_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036418">
        <property type="entry name" value="Cyt_c_oxidase_su6a_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11504">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE VIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11504:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02046">
        <property type="entry name" value="COX6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81411">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01329">
        <property type="entry name" value="COX6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF08152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="131" mass="15067" checksum="41D358A5F05C104A" modified="2013-05-01" version="1">MLGLRTASRTFTPAVRRITQKRLSSGTPNFTGAADNAFNRERAAVKEHAAATSDLWRKLSIYVVIPCLCIASVNAYRLWTEHWEHVAHGPSLEEKTEYPFQNIRTKNFFWGDGDKTLFWNPKVNYHKPSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M3CWV1</accession>
    <name>M3CWV1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoribosylaminoimidazole-succinocarboxamide synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_152427</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF08156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756277.1">
        <property type="nucleotide sequence ID" value="XM_016907440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CWV1"/>
    <dbReference type="STRING" id="692275.M3CWV1"/>
    <dbReference type="GeneID" id="27904577"/>
    <dbReference type="eggNOG" id="ENOG502SKGN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011750_1_0_1"/>
    <dbReference type="OMA" id="YLPWCLR"/>
    <dbReference type="OrthoDB" id="3057599at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021840">
        <property type="entry name" value="DUF3433"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544">
        <property type="entry name" value="SPRAY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11915">
        <property type="entry name" value="DUF3433"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="490"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="531"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="671"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="720"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="809"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="843"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF08156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="997" mass="109661" checksum="29FAE21E2010A17D" modified="2013-05-01" version="1">MAGPLHASNQGVFALRQTNVSSPSVIHSRPSLNSVAASEDYYSLSNSGSSGRSIESAAQAQASQQTITRFGTPPSRYRTPAQSQTQLRLITQPPPPPPSSSQPHPYHATVEDDPDEPTRKTPLRGEGQRRLSAELASAAAAPTTTTITPIPAGTCGVHAGSTTVPTPSQGQLRNGGIRRKPVPSVVMEDPDQAKRLTSRISPTMAQSSVAKDISRERDAPTPGVDDTPYIHFALDQLTRDEEVRGSRRYPGDGGRYSYDALNTGDVAAAEGRSGNWPIPAHIQQRHRYEEVLQEEQHEPERDIAVVPPARTSDRFSSQAQPLISQPQEQIKYATQAGPHQAAHPYGRVDQPQEPNVFIPVTQAESRQPPLNFVPGILRTPLLGLFILALLAYLVALIIAAAWSRSNRGLGLTRYDGFADGKYFVFRYLPTLLGMVILAWLFQIVAAVYRIAPFIAMTSAASPPSRLAGAKLPLQPRSWLRPYFGHFGARMPVVGTFLLLAWLQIFTIPLLASSFNVHQDSTGTWHWIAVQGAIWVVVGLYTLLLIASIVLLFAIGRTTTGLKWDPRSLADVIVLLERSNALDGDSETVPQLGYFRTANRPTDVFHAYGIADKPARSYEVHEGRIQEKRYSDPDMDVEAGQRYSKESMIHLRHNGQDRQSASSPLPWFLKPFFALLWPIVAIVLVLAFLIVSYLPSTRVSDGFDPMVEAAVDTFGFSGTNFLYSFLPALLATIALLGWYDIDLAYRRLTPFESLTSINHSESAKSNWTDDLTGDIAERTLLPSYTADFPILISLSAAVTGHYRMAFISTITLLSTAIPILAGGVFWAQFYIVPQRVLISADMPAYITLSVFVTIYALAYLAIWPSSALRGSGLPENIDTFAGIRDCLSQSRLLDDFTFRNPSSRTDLVTRLLSYSTPERSNKLEQQQQTMYSSRAGAEASRVSLADSIRGFGRARAQAAALPVPDRADDAMGPARYAFSRILGRDGREYMGIDRIRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M3CX20</accession>
    <name>M3CX20_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TBPIP-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_53039</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HOP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756788.1">
        <property type="nucleotide sequence ID" value="XM_016909253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CX20"/>
    <dbReference type="STRING" id="692275.M3CX20"/>
    <dbReference type="GeneID" id="27906390"/>
    <dbReference type="eggNOG" id="KOG4603">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063266_3_0_1"/>
    <dbReference type="OMA" id="QKYHREW"/>
    <dbReference type="OrthoDB" id="272266at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120231">
        <property type="term" value="C:DNA recombinase auxiliary factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120230">
        <property type="term" value="F:recombinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007129">
        <property type="term" value="P:homologous chromosome pairing at meiosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000709">
        <property type="term" value="P:meiotic joint molecule formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010774">
        <property type="term" value="P:meiotic strand invasion involved in reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010776">
        <property type="entry name" value="Hop2_WH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15938:SF0">
        <property type="entry name" value="HOMOLOGOUS-PAIRING PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15938">
        <property type="entry name" value="TBP-1 INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07106">
        <property type="entry name" value="WHD_TBPIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homologous-pairing protein 2 winged helix" evidence="7">
        <location>
            <begin position="20"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="85"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF08667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="219" mass="24910" checksum="7CD8D7F24B89FAE0" modified="2013-05-01" version="1">MAPTKKDGDVKEKKLSPDESSKLILDYLRTTNRPYSATDISANLSNKVTKAAATKLLKDMHERKEIDGKAAGKQIVYFAVQEEVEEGFEEAMQAKEAKMEEYRETIATLKAQEKELRQSLRSGASATTTTLPELQACVEKMEQEKLALADRLARLQSGSIKPVDPEKRARLMRERKKWAKISAARKKIRKELWETVLESVVEKERIEEIKEEIGIQGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M3CXX1</accession>
    <name>M3CXX1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphopantothenoylcysteine decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_22774</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the HFCD (homooligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756647.1">
        <property type="nucleotide sequence ID" value="XM_016908361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CXX1"/>
    <dbReference type="STRING" id="692275.M3CXX1"/>
    <dbReference type="GeneID" id="27905498"/>
    <dbReference type="eggNOG" id="KOG0672">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033319_3_0_1"/>
    <dbReference type="OMA" id="KGLACGD"/>
    <dbReference type="OrthoDB" id="1532798at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071513">
        <property type="term" value="C:phosphopantothenoylcysteine decarboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="entry name" value="Flavin prenyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359">
        <property type="entry name" value="HOMO-OLIGOMERIC FLAVIN CONTAINING CYS DECARBOXYLASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359:SF6">
        <property type="entry name" value="PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="Homo-oligomeric flavin-containing Cys decarboxylases, HFCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF08526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="230" mass="25439" checksum="0F45F0DF789A49D7" modified="2013-05-01" version="1" fragment="single">PPIPPILTSSHHHHDKTHHLLLAATGSVATIKLPQIILSLSHHTNLSIRLILTKSSIEFLRGQASEQPTLAQIFEFPNVEAIYVDEDEWRRPWTRGASILHIELRKWADLMVIAPLSANALAKVALGMSDNLVYSVVRAWDTTGLIDEARPGVRKKGIIVAPAMNTAMWNHPVTKRHLDVLEGEWNVANGGWMEVLGPIDKGLACGDKGGGGMREWKEIVEVIEKRMGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M3CYK5</accession>
    <name>M3CYK5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">H/ACA ribonucleoprotein complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_151700</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Non-catalytic component of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP), which catalyzes pseudouridylation of rRNA and is required for ribosome biogenesis. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs. The H/ACA snoRNP complex also mediates pseudouridylation of other types of RNAs. The H/ACA snoRNP complex mediates pseudouridylation at position 93 in U2 snRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9 10">Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
            <location evidence="1 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 10">Belongs to the GAR1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EMF08756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756877.1">
        <property type="nucleotide sequence ID" value="XM_016906987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CYK5"/>
    <dbReference type="STRING" id="692275.M3CYK5"/>
    <dbReference type="GeneID" id="27904124"/>
    <dbReference type="eggNOG" id="KOG3262">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080002_1_0_1"/>
    <dbReference type="OMA" id="KPQDGIV"/>
    <dbReference type="OrthoDB" id="2187159at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034513">
        <property type="term" value="F:box H/ACA snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000454">
        <property type="term" value="P:snoRNA guided rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.230:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.230">
        <property type="entry name" value="Probable tRNA pseudouridine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038664">
        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007504">
        <property type="entry name" value="H/ACA_rnp_Gar1/Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237:SF6">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237">
        <property type="entry name" value="NUCLEOLAR PROTEIN FAMILY A MEMBER 1 SNORNP PROTEIN GAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04410">
        <property type="entry name" value="Gar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 10" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="124"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="144"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00053712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF08756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="211" mass="21628" checksum="AB266DE7DBA30BE5" modified="2013-05-01" version="1">MSFRGGGRGGFGDRGGRGGFRGGARGGRGGFQQSYGPPDTVYEMGTFLHATEGEMVCESINVKIPYFNAPIYLENKTPVGKVDEILGPLNQVHFTIKPQEGIQATSFKSGDKFYIGGDKLLPLEKFLPKPKPPPGAPKVKKPRGAGGAGRGGRGAPRGRGGFGAPRGRGGFGDRGGRGGGRGGSRGFSGSGGFSRGGGRGGAPRGRGRGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M3CZB5</accession>
    <name>M3CZB5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SprT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_93392</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF09006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757127.1">
        <property type="nucleotide sequence ID" value="XM_016910611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CZB5"/>
    <dbReference type="STRING" id="692275.M3CZB5"/>
    <dbReference type="GeneID" id="27907748"/>
    <dbReference type="eggNOG" id="KOG3854">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012966_0_0_1"/>
    <dbReference type="OMA" id="RIEWANK"/>
    <dbReference type="OrthoDB" id="20772at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006640">
        <property type="entry name" value="SprT-like_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23099:SF0">
        <property type="entry name" value="GERM CELL NUCLEAR ACIDIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23099">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10263">
        <property type="entry name" value="SprT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00731">
        <property type="entry name" value="SprT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SprT-like" evidence="2">
        <location>
            <begin position="127"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF09006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="332" mass="37128" checksum="19E3A7CFDE1E79BC" modified="2013-05-01" version="1" fragment="single">MREVLERPSTPPPSPPRSPSKLKSPSKRAPRVPTPPGRPSLEAFWTADTVNDWNDQYSPQKPLRSPTKLFNNNISPIKNTFDDTPIPSPAKLRSSPTKRSKAAAAAELQARKDWDTRKVLLAESFLLELDQSLTQGQIARLAASTGGVKIIWSKTLNSTAGRANWRRETTKSHSRSDPSKPPLIEHKHFASIELAEKVLTYTPPPPPTDDNDNDDDDGNYQQQQQDPNETKLLNILAHEFCHLANFMISQISTHPHGASFRAWGNKCSALFGATRGIQVTTKHSYEIDYKFVWRCVSNLCDDGREGQGEEGGCGTEYKRHSRSVDPKRHRCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M3CZJ0</accession>
    <name>M3CZJ0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ino eighty subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_151116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758175.1">
        <property type="nucleotide sequence ID" value="XM_016906606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CZJ0"/>
    <dbReference type="STRING" id="692275.M3CZJ0"/>
    <dbReference type="GeneID" id="27903743"/>
    <dbReference type="eggNOG" id="ENOG502QVDM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007606_1_1_1"/>
    <dbReference type="OMA" id="TPNMRIN"/>
    <dbReference type="OrthoDB" id="5413003at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038014">
        <property type="entry name" value="Ies1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37287">
        <property type="entry name" value="INO EIGHTY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37287:SF1">
        <property type="entry name" value="INO EIGHTY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="748"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="489"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="517"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="748"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="790"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="816"/>
            <end position="856"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF10054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="856" mass="94396" checksum="64A28491D36F6918" modified="2013-05-01" version="1">MDLSSIMQPAEPARSPAPAPAVPIAAAAAAPPSQPPLPPPPSVDITPAPSPMPPKRKADQLDEDESVATPRDNSIHNGDNDRDEPMYTSTTTSVRHNKSGATSSVYSGNKIRHLKKEDGIPLWRKDIQYDFLKIVFDDTTKCFTKYSDGTHGHTFADIYIDAMAKSSKCSKILKEKLLQDQAGAISMAMVCLLVNVGRMNTTLNFFPEMRAQLRTYHSIPALQADQDPNAYKQLQDAPRLKSILKGATEDEPQPSTMEEIKAASMPRTNPVNLIFVMSQYAPKISEVHFPPPRDFFDLVMRPTLSSESRAKAFLWLIWWYLESDFSIEATQNNPFGAGVYGEGEEGTDVLPLKVPTLEALTDEQAELENVDTESEKHFGEVKRKERIAILASEPSPAMTALKRARKEKGLTTGHNPAPSDDEGSETGYHRMAGPTSVGRSALHHETASDYTRSPSPAARGFQAVNAKPLASGMGINTLLNSDDAAPENSPSRPVPAAAPAKKGPGRGNWRRNKAGKEATATAAGAAPSQPVPLLPNTGTQMQFVNNGPNGPVQSHGGSFAFGNTNKLAAATGISPGGQQLSFQSPATHIPTPSYQAQKRHRGITQHQSAVINHRKMQIDYTLDRRIRKSHEEARDRRESESPIIRAWKRLKYMPADYDSEEELGKIRKAKDRAEKNDDWHRGATVEDPFDNVDLWRRPRVLYAGYVKMPQEPGDVGEESKSLAQSFRRASRRLDRWQDNLPGQAMARRLEREQERERGHPPAARSRKSSTAGNGVEPVEENGVRPHKPAIKREKTEPKRRPSAKKATSGRGQQMDVDPEPDDEDGGAELDEEDRDLLAEVDADEDGSEEEDEDMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M3D065</accession>
    <name>M3D065_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">U6 snRNA-associated Sm-like protein LSm6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SEPMUDRAFT_151259</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway. Component of the nuclear LSM2-LSM8 complex, which is involved in splicing of nuclear mRNAs. LSM2-LSM8 associates with multiple snRNP complexes containing the U6 snRNA (U4/U6 di-snRNP, spliceosomal U4/U6.U5 tri-snRNP, and free U6 snRNP). It binds directly to the 3'-terminal U-tract of U6 snRNA and plays a role in the biogenesis and stability of the U6 snRNP and U4/U6 snRNP complexes. LSM2-LSM8 probably also is involved degradation of nuclear pre-mRNA by targeting them for decapping, and in processing of pre-tRNAs, pre-rRNAs and U3 snoRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758395.1">
        <property type="nucleotide sequence ID" value="XM_016906701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D065"/>
    <dbReference type="STRING" id="692275.M3D065"/>
    <dbReference type="GeneID" id="27903838"/>
    <dbReference type="eggNOG" id="KOG1783">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076902_7_4_1"/>
    <dbReference type="OMA" id="EQTVEYV"/>
    <dbReference type="OrthoDB" id="268799at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008266">
        <property type="term" value="F:poly(U) RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01726">
        <property type="entry name" value="LSm6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000037">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016487">
        <property type="entry name" value="Lsm6/sSmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F SNRNP-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021:SF1">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 15" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11 15" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="12 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 15" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="10 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="9 15" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Sm" evidence="17">
        <location>
            <begin position="21"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR006609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMF10274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="93" mass="9774" checksum="E8871BCEDD8E3FED" modified="2013-05-01" version="1">MSAAPSPPTNGAAASAAESRDPSGFLSEIIGAPVTVKLNSGVVYKGELQSVDGYMNIALEDTKEFVEGKMRRNYGDAFVRGNNVMYISADAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M3D0F4</accession>
    <name>M3D0F4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="16">ATP-dependent rRNA helicase RRP3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SEPMUDRAFT_68214</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759129.1">
        <property type="nucleotide sequence ID" value="XM_016909813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D0F4"/>
    <dbReference type="STRING" id="692275.M3D0F4"/>
    <dbReference type="GeneID" id="27906950"/>
    <dbReference type="eggNOG" id="KOG0330">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_1_1_1"/>
    <dbReference type="OMA" id="GIGIKCC"/>
    <dbReference type="OrthoDB" id="10261904at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17954">
        <property type="entry name" value="DEADc_DDX47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044765">
        <property type="entry name" value="DDX47/Rrp3_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF20">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="15">
        <location>
            <begin position="88"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="119"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="302"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="477"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="10">
        <location>
            <begin position="88"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="493"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="504"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMF11008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="516" mass="56995" checksum="F1269C08D5BC62FD" modified="2013-05-01" version="1">MAEDRVKRRKLSHDGGEKIKRVKSATSATRDVSDSKKKKQRRPVEEAEEEEEEEQEEKVAQAEAEGEGEGKGEEEGEEEGDGEEKRPKTFAELGVREELCDACISLGYKTPTAIQRESIPIALQGKDVIGLAETGSGKTAAFALPILQALLEKQDHYFGLVLAPTRELAYQISQQFEALGSLINVKCAVIVGGMDMTPQQIALAKKPHIIVATPGRLMDHLENTKGFSLRKLKYLVMDEADRLLDLDFGPILDKILQVLPRERRTMLFSATMSTKLDNLTRAALQSPVRVSISSSSYQTVKNLKQSYIFIPHKFKDIYLVYLVNEFAGQTCIIFTRTINETARIAFLLRALGRSAIPLHGQLNQSARLGALNKFRGGSRDILVATDVAARGLDIPSVDLVLNYDLPPDSKTYVHRVGRTARAGKAGVAISIVTQYDVEVYQRIEKALGKKLAEFGTEKDEVMVFAQRVQEAQRVAVQEMKNEHEKRGNKKGQGISGGRGKGGGGKRDRDGMDAEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M3D127</accession>
    <name>M3D127_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_110581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758319.1">
        <property type="nucleotide sequence ID" value="XM_016900852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D127"/>
    <dbReference type="GeneID" id="27897989"/>
    <dbReference type="HOGENOM" id="CLU_2039525_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF10198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="121" mass="13947" checksum="EBF5066115D739D5" modified="2013-05-01" version="1">MSGLGLAVFYLLRGGGCCSLAEDISARDNWLGWWHDEDDDGDDDEDDIDDDIDDDIDDDINTFCRLRDARRLGGESRRATWKSTIECAVEGSRKEAEVDEEEEEQQEEEEEEEDDDDQEYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M3D235</accession>
    <name>M3D235_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Phosphoacetylglucosamine mutase</fullName>
            <shortName evidence="14">PAGM</shortName>
            <ecNumber evidence="4 14">5.4.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 14">Acetylglucosamine phosphomutase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 14">N-acetylglucosamine-phosphate mutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">SEPMUDRAFT_150459</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, which is a biosynthetic precursor of chitin and also supplies the amino sugars for N-linked oligosaccharides of glycoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23804"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="5.4.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14 17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14 17">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.3" evidence="4 14"/>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759679.1">
        <property type="nucleotide sequence ID" value="XM_016906189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D235"/>
    <dbReference type="STRING" id="692275.M3D235"/>
    <dbReference type="GeneID" id="27903326"/>
    <dbReference type="eggNOG" id="KOG2537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022890_1_0_1"/>
    <dbReference type="OMA" id="WEAYATK"/>
    <dbReference type="OrthoDB" id="1928at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004610">
        <property type="term" value="F:phosphoacetylglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03086">
        <property type="entry name" value="PGM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000003">
        <property type="entry name" value="Phosphoacetylglucosamine mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000013">
        <property type="entry name" value="Phosphoacetylglucosamine mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000023">
        <property type="entry name" value="Phosphoacetylglucosamine mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049023">
        <property type="entry name" value="AMG1_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049022">
        <property type="entry name" value="AMG1_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016657">
        <property type="entry name" value="PAGM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45955">
        <property type="entry name" value="PHOSPHOACETYLGLUCOSAMINE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45955:SF1">
        <property type="entry name" value="PHOSPHOACETYLGLUCOSAMINE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21405">
        <property type="entry name" value="AMG1_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21404">
        <property type="entry name" value="AMG1_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016408">
        <property type="entry name" value="PAGM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 14 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 14 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="19">
        <location>
            <begin position="68"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="19">
        <location>
            <begin position="111"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoacetylglucosamine mutase AMG1" evidence="21">
        <location>
            <begin position="205"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoacetylglucosamine mutase AMG1" evidence="20">
        <location>
            <begin position="315"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase C-terminal" evidence="18">
        <location>
            <begin position="490"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="15">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <feature type="binding site" description="via phosphate group" evidence="17">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="390"/>
            <end position="392"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="517"/>
            <end position="521"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="526"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR016408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR016408-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR016408-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR016408-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF21404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF21405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EMF11558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="554" mass="60853" checksum="82D6F107C2082AF6" modified="2013-05-01" version="1">MAPGAFDTNGDLAKAIVESVDHFPRPEKYGDFAYGTAGFRTRGDLLDHVMYGMGLLAGLRSRKLNGQTIGIMITASHNPAEDNGVKLVDPMGEMLEQEWEKWATHIVNGKTPEETMRAYAQIVQQFDIDVEKAAHVVYGRDTRPSGVRLVKAVQAGLKATKVDAKDFGILTTPQLHYLVRATNTAKDPNPYGEISEEGYYKKLAAAFATVMKYTKASSPVTVDCANGVGAPKLKELMKHLPSESETGLHISIVNDRIEDDKLLNKDSGADFVKTSQKVPLGFTGKPFDRWASFDGDADRIVYYFVEEGKIFRLLDGDRIATLAASFLGELVEKSGLADKIKIGVVQTAYANGASSKYISETLKLKSAFTPTGVKHLHHEAARYDIGVYFEANGHGTVLFGTDALRTIHKQEPQSPAQLENLEILRGLTEVINQTVGDAISDFLLVETILAHKNWSVKEWLATYTDMPNKLAKQVVADRSRFKTVPGTAEQKLQCPEGLQEKIDAEVAKYSNGRCFVRASGTEDAVRIYGEAREAYDVDHMVASVASLVVNKNDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M3D2Q1</accession>
    <name>M3D2Q1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Vacuole-associated enzyme activator complex component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_149153</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VAC14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760616.1">
        <property type="nucleotide sequence ID" value="XM_016905375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D2Q1"/>
    <dbReference type="STRING" id="692275.M3D2Q1"/>
    <dbReference type="GeneID" id="27902512"/>
    <dbReference type="eggNOG" id="KOG0212">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007740_0_0_1"/>
    <dbReference type="OMA" id="QCYQHVS"/>
    <dbReference type="OrthoDB" id="5574975at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070772">
        <property type="term" value="C:PAS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026825">
        <property type="entry name" value="Vac14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021841">
        <property type="entry name" value="VAC14_Fig4p-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16023:SF0">
        <property type="entry name" value="PROTEIN VAC14 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16023">
        <property type="entry name" value="TAX1 BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12755">
        <property type="entry name" value="Vac14_Fab1_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11916">
        <property type="entry name" value="Vac14_Fig4_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="5">
        <location>
            <begin position="86"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar protein 14 C-terminal Fig4-binding" evidence="7">
        <location>
            <begin position="635"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="275"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="492"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="881"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="278"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="298"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="352"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="507"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="912"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="928"/>
            <end position="939"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF12495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="949" mass="105094" checksum="9FFC1402C8DBB460" modified="2013-05-01" version="1">MDSNSLKLLSDKFYDKRKAGALELETVIRAALAEQNHERIGKIVWQLCHDYAYAVHQPHARNGGLIGLAAAAIALGAEVARYLKEIVPPVLACFSDQDARVRYYACESMYNIAKVAKGEILIYFNDVFDALSKLAADTELSVKNGAELLDRLIKDIVSESAATYTSVLLTEGKESAELTPDQSVDIPQAFNLAKFIPLLQERINVQNPWARTFLVQWILLLDSIPDLELVSYLPCFLEGLLTFLGDGAADVHNTTKEVLKRFLKEIGKIAEVKQNVAESRKSRDDHELDRKASVASDAVEDPTSDVEEPEADPAQSRESRENGETLATETPDIAVGEEDAIGDGASSFTAADGEDAEGPSAEDEWIPGQDVQIDYPRITAILVDFLARSREEAVQLTCLNWIGTFLEICPEDILPFTPALLQQLLPALSHDNDHVSDEAKRVNNELMRYIMSLPDDPTRAHGGSVEQPLQTSTPAATVANATSGMRALRDNAGDVKRESLSGRAARRTPEVPESRTPDVATPEPPVEDAEVVDAHPDLDYEAAVSALTLQFLHEHEATRVAALAWLIMLHRKSPRKILAIQDATFPALLKTLSDPAEAVVTRDLLLLSEISKSSDQSYFTSFMVNLLKLFETDRRLLESRGNLIIRQLCLSLSAERIFRTMADCLENDEDDVEFASIMVQNLNNNLITAPELGELRRRLRNLDSKDGQSFFTVLFKAWCHNAVATFSLCLLAQAYEQAYNLLLIFSEIEMTVNMLIQIDKLVQLLESPVFTYLRMQLLEPERHPNLYKCLYGLLMLLPQSSAFAALKNRLNSVSAIGYLHIRDRSGPPVPAASNLSNFGERNRLKNREDGGGIKWTELLEKFKATQEKVRRSQRRQLINQHGLEDAAAPLKEPVKTLQPPAPQPKPDHLQQPAARPAPGAPTGHQRNKSSLGTLGSRLTGSRGAAKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M3D3R7</accession>
    <name>M3D3R7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_117402</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760976.1">
        <property type="nucleotide sequence ID" value="XM_016901336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D3R7"/>
    <dbReference type="STRING" id="692275.M3D3R7"/>
    <dbReference type="GeneID" id="27898473"/>
    <dbReference type="eggNOG" id="KOG0605">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_19_1_1"/>
    <dbReference type="OMA" id="DNERWAR"/>
    <dbReference type="OrthoDB" id="3638488at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF400">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CBK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="381"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="394"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF12855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="434" mass="50782" checksum="3097B9F5FF123B9D" modified="2013-05-01" version="1">MKWIHRDVKPDNFLISASGHLKISDFGLAFDGHWAHSQLYYTNVRETMLERVGIKPTGDELDVAQEMEFGSPEHEFKPPSPPRRGFLTRAQAEEHAHREGLLSWRNRHDRRKMARSVVGTSQYMAPEVILGANYDGRCDWWSIGIILYECLYGRTPFYSETRVKTKECIVNHRHTLHFPMQERFARPLTPQRIALPTPSDWAVDLLRGLLCEKERRLSSRQYRHSDPRMPIRRLSASHNNPLARHVFSNDADEIKKHPWFADVPWTQMHLSTPPFIPKVKENQSITKYFEDEKDIMSVESSSFASVRDLIPDDADEGEAALVLGAHFERWKAEKIQREKMELGIDQYPDAELQRIKEHFGNRYQEWRAQRMVEIAEHMADGGHEMPLPPQQQQQRHKKERKRARDKVLRDPLMCKVVMEEDHDETYDFAGGEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M3D671</accession>
    <name>M3D671_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_43458</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761485.1">
        <property type="nucleotide sequence ID" value="XM_016908896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D671"/>
    <dbReference type="STRING" id="692275.M3D671"/>
    <dbReference type="GeneID" id="27906033"/>
    <dbReference type="eggNOG" id="ENOG502S1MK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051552_0_0_1"/>
    <dbReference type="OMA" id="DMGEDLH"/>
    <dbReference type="OrthoDB" id="21266at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070692">
        <property type="term" value="C:CTDK-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032786">
        <property type="term" value="P:positive regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000032">
        <property type="entry name" value="CTD kinase subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042326">
        <property type="entry name" value="Ctk3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024637">
        <property type="entry name" value="Ctk3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024638">
        <property type="entry name" value="Ctk3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28291">
        <property type="entry name" value="CTD KINASE SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28291:SF1">
        <property type="entry name" value="CTD KINASE SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12243">
        <property type="entry name" value="CTK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12350">
        <property type="entry name" value="CTK3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="2">
        <location>
            <begin position="3"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF13364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="246" mass="27899" checksum="26283E4C5FD76ED0" modified="2013-05-01" version="1">MADPFEVRMRFTSQLQHLSASSSSATKAANYALRHSEYADDLHSCILEQLERNNMNLRANIMYFLPALCDAAKHGLANGGLATEAGVYVRMVERDILRIIDLVAPDDGSGAANVKVVRKVLQALMGRGVLQSQTVRELEEMMQGRDNLPGASIRSTPQSTAHPSFGHHGVRLDKRQIEQRIEEDRERHKRARENIWAVPQQRGGDMATDKEFENVWDSGSDVDSDDYRMAEEEADERRRHLEYDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M3D6M0</accession>
    <name>M3D6M0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor 38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_132796</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PRP38 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761640.1">
        <property type="nucleotide sequence ID" value="XM_016902516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D6M0"/>
    <dbReference type="STRING" id="692275.M3D6M0"/>
    <dbReference type="GeneID" id="27899653"/>
    <dbReference type="eggNOG" id="KOG2889">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039466_0_0_1"/>
    <dbReference type="OMA" id="GEHFKYL"/>
    <dbReference type="OrthoDB" id="190958at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005037">
        <property type="entry name" value="PRP38"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23142">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03371">
        <property type="entry name" value="PRP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="187"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF13519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="246" mass="28215" checksum="F73BC2CA32DA39DA" modified="2013-05-01" version="1">MAHQADAKRALDERGYSGTLIRGDNPLKLFEKAVRDRIIDSYYWKEQCFGLNAATLLDRAVELSFIGGTYGAAQKPTPFLCLAFKLLQLTPEREIITFYLEKAGDEFKYLRALAAFYIRLAWEKDEEVYTTLEPFLADGRKLKRRVREGWALTHMDEFIDDLLTKTRVCATTLPKINTRLHLEDADKLEPRESALGDELEELDRDEDDEDDRSSDGEAQENGHARSDGHDSEDGRRENDEEMSDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M3D6Y6</accession>
    <name>M3D6Y6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_149040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762026.1">
        <property type="nucleotide sequence ID" value="XM_016905301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D6Y6"/>
    <dbReference type="STRING" id="692275.M3D6Y6"/>
    <dbReference type="GeneID" id="27902438"/>
    <dbReference type="eggNOG" id="ENOG502RV5A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_821756_0_0_1"/>
    <dbReference type="OMA" id="QEWIERS"/>
    <dbReference type="OrthoDB" id="5365739at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF13905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="338" mass="36166" checksum="42D84511627EBE1A" modified="2013-05-01" version="1">MITRRAYTALSLAERQVIQSQYAGSGQCVRCFHHARRQQADELRPEDGSPAIKDSAKRAENNGPQIQPAPTKRARAQIISNEISALQRGPPPGDPTSGPGSLAGTNQTNPSPPTVSAGFTETPTSLGAGGRMGENISAGREGVNAQGVGRFSGSDERVRNEHSRPQGTRNPHEVQEPAEGGQSVLEQASAPRSSRGPLEGEARLRSIMKDARPLGLPVRPQASSVTAQRLVLQGRGTGVPLASQPIATIHDRFTLVTNPANNNRGRGSQRLSQAESEALTKVLVGGQYDNEGLLNGKKIHEVEILNVIKRQTMMNGTYLGKDGDRLVKKVERLLPASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M3D827</accession>
    <name>M3D827_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_61991</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762140.1">
        <property type="nucleotide sequence ID" value="XM_016909583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D827"/>
    <dbReference type="STRING" id="692275.M3D827"/>
    <dbReference type="GeneID" id="27906720"/>
    <dbReference type="eggNOG" id="KOG1188">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_475802_0_0_1"/>
    <dbReference type="OrthoDB" id="25131at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039328">
        <property type="entry name" value="WDR89"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22889">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22889:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="143"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="406"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="341"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="447"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF14019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="573" mass="61886" checksum="293277254B26EE60" modified="2013-05-01" version="1">MPTKCVGSLATSADNYLFALAKGTGTGTHLATIGSDDALRYVDATSLQATNTVANAHSGLSCLQAATHASFVTGGRDGLVRCWDARAQRGIEMLDPKANGISSLACREQYIAVGTESLKEGLGDVSVLLFDTRNPRQPIRQYNESHTDTVTQLQFHPAQPHVLLSGSTDGLVSVFDVNHEDEDDALQQVLNPRSAVHCAGFLAHDEAYVVSTDEKYSIYTLAKTAAEDEELPPPTQFGDVRDQLDCMYVIDILVQPDGPPLIAYGHNEKRTLGISSLGIPGAWAFGQKIDLPGAHGEEVVRDLLLIEKRAFSCGEDGNVKAISSLSQKLEALADHSNSGHSPSSTPTLSTTLSRFPLPTSITMTQMKEPADIRAIKSLIQDFFNAINAADTKALGHTFLPNGTLAIIRQDPPRNPTSGSGSSGSGSQEDYYPQYAALPTPTGPPPTGSDNNDSNTTTTASEEQKISVIMRSSIEKFIKLIDEASRKRREGGAPDLKIVETPDLDATDVKVDALFGMAWSPFKVTFDGVLHHYGTIVYTLCKKKKEGEEDGWKIAGLTQNYRRAVGWEKESEFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M3D9J1</accession>
    <name>M3D9J1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_148224</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762660.1">
        <property type="nucleotide sequence ID" value="XM_016904784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D9J1"/>
    <dbReference type="STRING" id="692275.M3D9J1"/>
    <dbReference type="GeneID" id="27901921"/>
    <dbReference type="eggNOG" id="KOG2069">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025395_1_0_1"/>
    <dbReference type="OMA" id="DAMKDMT"/>
    <dbReference type="OrthoDB" id="1661054at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007255">
        <property type="entry name" value="COG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21311">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21311:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04124">
        <property type="entry name" value="Dor1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="304"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF14539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="523" mass="56301" checksum="2FFBD01ED58D2199" modified="2013-05-01" version="1">MADPLYELLARYFDTDTALAAAPSPHDPQTASYLSRLGALSLADLTSSEPASLLQSAQSHLRNLQALSKRSHKAVISSSSHLAHLTSLLPEFGSQAQVLGSSVPGLENAAADFAHKYDRSTENEVLDRRKRAVLLSRNVDRVSDVLDLPNLLSSTVAAAQASSSGSATASGATTSYASALDLHAHIKRLKALYPQSDLMANISTQAEDEMQNLATILIGSLQSPNLKLAAAMRTIGWLRRVAPDLAAHVSPISKPGLLTTKTLELSANAVNDDGAIGSLFLVCRLRTLHETLDALEPLRDLADAETAQRKASPTTNGNSARSMAESSSFVSSGTQSERFLKRYIEVFREQSFNILSMYRSIFPANLPSPDNSRTASASMASNADEHPLLPLPSPVSDFALHLVDMLEVTLHEYMPNISDKSFRESLLTQVLYCAGSLGRLGADFGMMIALLEDDLAEHDNTELETSADNAELEREWEQVMKKHRIQASRLEVLARGVGTSRKVSTDLTSPSAITPVAQSLSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M3D9N9</accession>
    <name>M3D9N9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Isochorismatase hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_132215</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762710.1">
        <property type="nucleotide sequence ID" value="XM_016902482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D9N9"/>
    <dbReference type="STRING" id="692275.M3D9N9"/>
    <dbReference type="GeneID" id="27899619"/>
    <dbReference type="eggNOG" id="ENOG502QRZN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005335_0_0_1"/>
    <dbReference type="OMA" id="KMYHLSG"/>
    <dbReference type="OrthoDB" id="445341at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00431">
        <property type="entry name" value="cysteine_hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032854">
        <property type="entry name" value="ALKBH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212:SF5">
        <property type="entry name" value="ISOCHORISMATASE FAMILY PROTEIN FAMILY (AFU_ORTHOLOGUE AFUA_3G14500)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="600"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="276"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="371"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="453"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="299"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="396"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="454"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="471"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF14589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="788" mass="87073" checksum="14D690AD72A7BE8C" modified="2013-05-01" version="1">MSFLSALLSQQTPNLQTRKGLIVVGLQNDFILPDGKLPVKDAAFVNRIGSLVPAFREHGEIIWVRSEFQQTRPVNGDDTPGDRVIAAGSLGTGLDRQRSGDVPAANKKYKFSASFEKPEAGKEEGDDEELFLSRTSKREPCCIKGSHGADFSDRIKPLIQRKDLQVVKSHYSAFAGTSLLMTLRSKLITDVYICGCMTNLSVYATAMDAARYGIEITLVEDCLGYRRFDRHQMAVQQLNHFMSANFWKSARVLAQLLDPSLEFPSSDSGAIEVVVEEEDDDDDDDDDDEDEDEEEQTEEQQHKGEEEKQEKEATEGSTVMGDRRSTLLQAQADVLEVDSDEHSDEEVSLPTVGLPRRLLDRISERSFATRLSSKYSPRAARRPRITTTQYATPESPRSDPRHNDPGHESEKGAIEFGKLKFATASGHSRLISTHSGSSRQVSRLPWLDIIPPNYKSSQDIGPPASSHQQGSPCAPSQSTASPPSSGGKKPKAMSTCSQKSRPLFGEDKVAESAGSRILHGLLPEDAAETAFEDVQSEVKWQSMFHQTGPVPRLVSCQATICDDGSVPLYRHPSDQTPEVHAWTPTVDRIRKAAEQVAGHRLNHALIQLYRDGNDFISEHSDKTLDIAPDSNIVNVSMGAQRTMRIRTKRGAGTGSGNTAEARTTYRVPLPHNSMVTMSLQTNAEYLHAIPWDRRPPCELVEAEKAFGGQRISLTFRCIATFLSQDRTMIWGQGAVGKSKDTARRVVHGDPEESQKLVDAFGKENAASSIEWKEIYGSGSDVLHLKQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M3DAD5</accession>
    <name>M3DAD5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_123439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763176.1">
        <property type="nucleotide sequence ID" value="XM_016901841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DAD5"/>
    <dbReference type="STRING" id="692275.M3DAD5"/>
    <dbReference type="GeneID" id="27898978"/>
    <dbReference type="eggNOG" id="ENOG502RGYN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_550008_0_0_1"/>
    <dbReference type="OrthoDB" id="5388207at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="368"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF15055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="496" mass="51064" checksum="E4D64B50EC660198" modified="2013-05-01" version="1">MSKHDPATSNQGLQFVGGTSTPTSAVSRGNGPQSRSAISKAVDEGALERREDPAHSDKSLAFISAPKQTHTTDPIVPKTTEHEPHSGTLGGYTIGQPLGTTQNKAVEPVSAGLPVGMDSKKTATIEPYPTPKDPQNLSNPTAAGPDTTYNPQPLDQDGDKPVQTGPAFISSLFSNPFMKRENVSSTSEDADLDPKFQAPQISAPSSEAQGNTARVQPADGKGPVATQSSAATNGADSIVVEPRGDSGTLLPNHLGPNVPPGAASPKREKGKGKMYGDADSISTRSSLTRNESITTSQTGPSTIDSRRFSSHTPGKIPTAGGIILGERAGQDRERRASLAPSGHSAVTTEPHHAGRESLQKVAEDAEQTRVAPVAPSTPAVRSSSPTAAPTSTTSTPAALPKDSTDASKSPTSGRVPGTESGSLASPTSPPANASRFSEQGIRGSDVTSDIAASSTPAERKPSLVTRIGRKLSIRSKHGRSGTSASTSHPDTIAETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M3DDB0</accession>
    <name>M3DDB0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_37484</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763935.1">
        <property type="nucleotide sequence ID" value="XM_016908671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DDB0"/>
    <dbReference type="STRING" id="692275.M3DDB0"/>
    <dbReference type="GeneID" id="27905808"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_11_1"/>
    <dbReference type="OMA" id="LAMGQPN"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF230">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="419"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF15814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="474" mass="53502" checksum="DD1CD0D1BBA35426" modified="2013-05-01" version="1" fragment="single">FFIGRALYRIYLHPLRAFPGPKLWAISRLPWHVHNIRGDLARTIHALHEQHGPTVRIAPDELSYTSSQAWKKIYGQTHPEFSKCLDGRGIAPVTKEAHLRGIIAAETLKHRRLRRAIAPAFSERALSQQEHCLQKHSDSLMRCLRERCNRGEPLDIGRWFSLTTYDIITELTFGHADGCLNDPDKPWLTVMGARAKTIRWFQFAIYYGFDGLIARVGPSVMTRSRQAHMKMLGSKVQRRLKEKDMGMDFMSHILDNRSEPLSVSELVIMASAFVVAGSGTSARALSATTYFLCCHPDKLALAVDEVRAAFLDESSITIKSAATLEYLFACIQEAMRMHPPNPSTLPRWVPADGEVIEGAWVPGGTAVGVHQLSAGLADWNFARARTFLPERWLELPQKSEFERDDRASAQPFSYGPRGCVGTNLAHAEMRLLMARLLYTFDVEITAQAQEWTASQKSYLTWEQTPLMVKLTVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M3DE06</accession>
    <name>M3DE06_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_162034</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764096.1">
        <property type="nucleotide sequence ID" value="XM_016907975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DE06"/>
    <dbReference type="STRING" id="692275.M3DE06"/>
    <dbReference type="GeneID" id="27905112"/>
    <dbReference type="eggNOG" id="ENOG502S1X9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015361_0_0_1"/>
    <dbReference type="OMA" id="DIWFRIS"/>
    <dbReference type="OrthoDB" id="10031947at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052073">
        <property type="entry name" value="Amide_Lactam_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171">
        <property type="entry name" value="FARA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171:SF6">
        <property type="entry name" value="SPECIFIC TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G06130)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="263"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="39"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="549"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="63"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF15975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="620" mass="69722" checksum="228DF2600026EDAB" modified="2013-05-01" version="1">MALELTFVNQYGDSAPKRRRLAKACESCRTRKKRCIHFPAADESEKERDRQVEDESEADGPPSNGNTNGSLPAPTGSTASISRRFISDLVPESTFLQRHQPAAPQEIREQNDDIGIWVDRREYDALVRQKNTARDEAAEATAGEERPHSTAYTPLIDIYFRKLHPVLPLLDEAEFRRDYARGVVPEALVHAVCLVAAKHSEAAPYLRLNESSTPLVAREFCRRLHKSLMVALRVPGRYEKITLIRTLALASLHAESAEGAEEATLCLNQAMHYLQTMGWHLGQHTGVTSSDDLQTKRIFWCLWSLDRVNSCIYGRPIMMSDIDVAIEPFESGESGFPAFEVWLCITRTLNKVIGFYRPGVPLEVSGWEEDFPSFEDAIEEGKGHNLDRPTMATLHLYYMLVAVLSHRSRGVKFVSRSTNSYVRQSLCAIEINRLMSSHLLPTLLPFPILSYAISLAMSVSYQHLRQSQLQHQQEDARQDFKSCCQILQKLRRTWSSADVIATIARKVLDQLEKAPDLAVFRVTRGSEEGRHSPHICAASFWKPHTLVDHPTADNATAESEGNESAAPDVEQQPATEADWLGMFEGIDDIFGTYLDPNYPVNLDDISFVDDLSPLDWSAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDE7</accession>
    <name>N1QDE7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SUN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_72063</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757516.1">
        <property type="nucleotide sequence ID" value="XM_016909967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QDE7"/>
    <dbReference type="STRING" id="692275.N1QDE7"/>
    <dbReference type="GeneID" id="27907104"/>
    <dbReference type="eggNOG" id="KOG2687">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_399613_0_0_1"/>
    <dbReference type="OMA" id="GQCWCAG"/>
    <dbReference type="OrthoDB" id="342281at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034993">
        <property type="term" value="C:meiotic nuclear membrane microtubule tethering complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045119">
        <property type="entry name" value="SUN1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911:SF8">
        <property type="entry name" value="KLAROID PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911">
        <property type="entry name" value="SAD1/UNC-84-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="SUN" evidence="7">
        <location>
            <begin position="402"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF09395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="606" mass="67757" checksum="1BDA21466969CC3E" modified="2013-06-26" version="1">MSGATPRITRSRANTPLPSISTRQSHAYGARGKAAVSEQVTTSTAEMDAAFASTARPRGSARPRGAATPAAAKNKKAKATPVIEEYEDDDEDEEEDEDLSRPGTAIQYSAAYINPPAIEGDYQPGAFVRFLLRIVHLISLIYGQGWQLAITSGLTFMAFWFLFCMVVYYSTAGWVATRDIPTIEMARAFGECASMKLFSDNIQQLNMSEYQWAINAHLLGRVESLENDTSILQQHLDIHRAMIDELQQILPNTIAMAEEDGELAIPPLFWKALANKMQSPDASPLWQYFLDTNAQQLRTLSKEVFSDNFEEMVKSKRAVSQDDFNLILTQHSEAVHEDLEQTVRKFKISVLEEARNVAVGVLEKSEIMSLARMQIQALGQANYIHNIDKRIRQVNYIGLGLGAMVDPHYTSDTKMPSTQTWSQWMLHHAGLARQYPNPPSVALIAWEDATDAWCAAPSQDEKALAQLTVKTAHKIFLTELTIEHIPSTGTRDSASAPKDFEIWVQVDNAREAKRINKANEGMIQWHTSTGSACKGKAPNGEKNWVCLAGEKYDIHEHNFVQNFRVWPDTQDLNIATNRVAIRVLSNWGNTQHTCLYRVRATGVEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDK1</accession>
    <name>N1QDK1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class I glutamine amidotransferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_72292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757641.1">
        <property type="nucleotide sequence ID" value="XM_016909982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QDK1"/>
    <dbReference type="STRING" id="692275.N1QDK1"/>
    <dbReference type="GeneID" id="27907119"/>
    <dbReference type="eggNOG" id="KOG3179">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054974_0_2_1"/>
    <dbReference type="OMA" id="PWIQTLK"/>
    <dbReference type="OrthoDB" id="92161at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01741">
        <property type="entry name" value="GATase1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044992">
        <property type="entry name" value="ChyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695:SF5">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="1">
        <location>
            <begin position="42"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="252" mass="28714" checksum="DAE41A67FC2CDC95" modified="2013-06-26" version="1">MRHHAPLRIAVLECDTPIGRTKEKYGGYGNLFKELLSNGAKLLQEKGEGEVELDITKYDVVNQEVYPELENVDAVLLTGSRHNSFDNDPWILKLVDFTKKVLQHDRVRLIGVCFGHQIIGRALDVKVDRSDRGWEVSVTKVQLTEQGKKLFGIDELAIHQMHRDIVYEYPPGTEALGHSPRCDVQGMYIKGRLITIQGHPEFNGELVAELLDNRHERGIFDDAMYKEGMERVRNPHDGVVVGAAFLRFLREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDL2</accession>
    <name>N1QDL2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_92347</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757672.1">
        <property type="nucleotide sequence ID" value="XM_016910585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QDL2"/>
    <dbReference type="STRING" id="692275.N1QDL2"/>
    <dbReference type="GeneID" id="27907722"/>
    <dbReference type="eggNOG" id="KOG1812">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057738_3_0_1"/>
    <dbReference type="OMA" id="CHYLPAN"/>
    <dbReference type="OrthoDB" id="1431934at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20335">
        <property type="entry name" value="BRcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="1"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF09551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="246" mass="27793" checksum="9AF53691FE0790DD" modified="2013-06-26" version="1">MCCEEKVGGSFPSWTGRHAANHHDTSPGEVCFACWEIYLQMQIEATSTDKIKCAECNVLLAEADIRHLVGRTTYDKYTDKASLEFMKQDPLFRVCPSATCSYGYIHTTAADGNIFRCQLCQCRYCILCEVVMHEGETCGDYQLRVRKQPGAHKKHETASRKYLKAHSKKCPKCTIHIQKNHGCDHMTCNLCHHEFCWVCLATYNGPRGIHRRGNEAHRKGCHYLPANLPSIASEEAGMWDSDGGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDM5</accession>
    <name>N1QDM5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AEX-3 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_166243</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757702.1">
        <property type="nucleotide sequence ID" value="XM_016908212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QDM5"/>
    <dbReference type="STRING" id="692275.N1QDM5"/>
    <dbReference type="GeneID" id="27905349"/>
    <dbReference type="eggNOG" id="ENOG502QW1Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007774_0_0_1"/>
    <dbReference type="OMA" id="IQDPDWW"/>
    <dbReference type="OrthoDB" id="6019893at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032483">
        <property type="term" value="P:regulation of Rab protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051696">
        <property type="entry name" value="DENN_Domain_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005113">
        <property type="entry name" value="uDENN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296:SF31">
        <property type="entry name" value="DENN (AEX-3) DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G11200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03456">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00800">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="3">
        <location>
            <begin position="86"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="705"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="792"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="528"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="711"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="827"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="844"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="874"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="884"/>
            <end position="893"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF09581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="948" mass="106655" checksum="E44D656707E3B21C" modified="2013-06-26" version="1">MAPSSSFTSNVMSRSRSGESARPPTRDDANLEIPNRTSSLHSRIAAPIPSQMPQQKTGTRAPKTLTHAYMVCGVGREPSQWVKAPIPAQGKIGHMKGAVGQFWLPEILGSSPRLEQDNEIARSLHSAMRACFPHDVEICTGSSQPHCVHHAFVLQQDSSHTLYGIALRVWSRADEKRAETIRDLRKRTEPDYYDTPGETYWIPYCLSFLSRYPLYNLLGDYLRGMWIHWNKATNLFHAEEVSRILSFPAPRLNDLVRIDMKDYALCYQFPSSPTGFQNFAMWPLFSCLSIPNIVGVLEAAVSPTRRIIFISHYTAMLTVATETVRYMVRVYEWSGLYVPVVHARHAKELVQEPGPYILGMTAECRTLFTAPSDALVVDLDRNFVLTSSPPNAWSARQRSKLITRLTQGLNGDVVPSGVPQHLRSAYGGGKLIPAGQIIVMRGEVESVQDPVWWNQDQIMRVMDHACEKLGRNTGLKSVFGGSQKKPLMTKVSMRHLNEIVRERNQYSRDAMEAWQDFINLKGRMDTELAKVTKRNNFLVEELESWKQQFLKFQAFAEQLTKETNELKVKIEGHKRENRRLTSMIDQQKDDTARLTVRLSGTEKQRDDALEALVLQQEIAEELERERKRNKKDLSALQHTNTTLLRQRDEAQRVVLHLRALIDGQAHHMEHIVKSLNDSETHGEFMDAEEQIESPVKEVAKDDVEAGATKVPASQVSSRASTRMSQYRNDGEDLSSFRQPRYSSISKRLSGLSMTEVADRHLRDKTDAIAYIIRNISEQCAAAVEGLDLARRADTTSSDGGDEDHRSESGKKRGKRPVKHLAPESENGDLSSNNSESDYGDNRSEGTSSYLHPKRTSGTSSAVPPTPDLVHDRSSTSMSVNSESTAATPNRSSLQSVYKNHADTIPEVPTHIMEHDSDGGHQLEEIAEEPVSKYATRGLEHHHGPLERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDS2</accession>
    <name>N1QDS2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Deoxyhypusine hydroxylase</fullName>
            <shortName evidence="10">DOHH</shortName>
            <ecNumber evidence="10">1.14.99.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Deoxyhypusine dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Deoxyhypusine monooxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LIA1</name>
        <name evidence="13" type="ORF">SEPMUDRAFT_151631</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[eIF5A protein]-deoxyhypusine + AH2 + O2 = [eIF5A protein]-hypusine + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:14101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="Rhea" id="RHEA-COMP:12592"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="ChEBI" id="CHEBI:91175"/>
            <dbReference type="EC" id="1.14.99.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="10">Binds 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the deoxyhypusine hydroxylase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.29" evidence="10"/>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757827.1">
        <property type="nucleotide sequence ID" value="XM_016906939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QDS2"/>
    <dbReference type="STRING" id="692275.N1QDS2"/>
    <dbReference type="GeneID" id="27904076"/>
    <dbReference type="eggNOG" id="KOG0567">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053974_0_0_1"/>
    <dbReference type="OMA" id="LQEPCSI"/>
    <dbReference type="OrthoDB" id="421002at2759"/>
    <dbReference type="UniPathway" id="UPA00354"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019135">
        <property type="term" value="F:deoxyhypusine monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03101">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027517">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697:SF5">
        <property type="entry name" value="DEOXYHYPUSINE HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697">
        <property type="entry name" value="PBS LYASE HEAT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10" id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="11">
        <location>
            <begin position="247"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF09706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="328" mass="36054" checksum="D4DD2BDCB5E18C2D" modified="2013-06-26" version="1">MAITPEDQIVAVLRKDLCSEDVALAKRFRALFSLKHLASQNPATPQSIPAVEAIAAAFTSPSALLKHELAYCLGQSGKEEAIHFLRAVIEDRKEDPMCRHEAAEALGALGDQTSLPLLRERRDDKSEEEVVRETCEIAIERLEWESSEAGKKEKLKQSDFTSIDPAPPSALDEKPDIVELQRKLMDSSLPLFKRYRAMFTLRDLASPPDLPTAVPAIKALATGLKDSSALFRHEVAFVFGQLSHPASIPALTECLSDTKEASMVRHEAAEALGSLGDEDGVEDTLKKFLDDPEQVVRDSIIVALDMAEFEKNGEMEYATVPSQIETTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1QE60</accession>
    <name>N1QE60_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_69906</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758736.1">
        <property type="nucleotide sequence ID" value="XM_016909881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QE60"/>
    <dbReference type="STRING" id="692275.N1QE60"/>
    <dbReference type="GeneID" id="27907018"/>
    <dbReference type="eggNOG" id="ENOG502R16K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003021_1_0_1"/>
    <dbReference type="OMA" id="TMHQKYN"/>
    <dbReference type="OrthoDB" id="207120at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11887">
        <property type="entry name" value="SH3_Bbc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057402">
        <property type="entry name" value="AIM3_BBC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035552">
        <property type="entry name" value="Mti1_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46026">
        <property type="entry name" value="RHO-TYPE GUANINE NUCLEOTIDE EXCHANGE FACTOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46026:SF1">
        <property type="entry name" value="RHO-TYPE GUANINE NUCLEOTIDE EXCHANGE FACTOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25459">
        <property type="entry name" value="AIM3_BBC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="2"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="42"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="234"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="955"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="239"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="267"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="354"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="408"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="443"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="462"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="479"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="593"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="657"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="709"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="750"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="778"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="799"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="893"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="917"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="955"/>
            <end position="967"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF10615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1199" mass="129047" checksum="0662EE6BA4182566" modified="2013-06-26" version="1">MASLFKVKALYDFEAKEDDDLGFPGGQVIDVTEEIDDNWLEGKYTDASGASQSGIFPREFVEKYEPPVPSRPTRPTRPKQEPVPVPVPVSEPEPEPEPEPPASARAPELQKDDADDAPAVPAASKPQPPPVVEPVVVGKQEEVRSPPSSVRSPVIPSEPPAAPKATPAEPATGGSKKPPPPIAAKSNAFRDRIAAFNQPAAAPVAPMVPGGPRSGANTFIKKPFVAPPPMANSYVPPAIKHEPVYKPYIREEDPEIKRRQEEDRAAAEAAGFSAVAEPSGEPQKEDEDAPKPQTLKERIALLQQQQLEQAQRRADGGTRKEKKPAAKQASEAPPEQGHLQDLDAEDDTADQEHSSVPTRQSSEAPGEQPRVAATQRKPSVPLSPVPTVPESELVSDGNEADQSAAGETTEDDAGTIGPEDSDETSAPPPPQRAATAPRREPEPAQEDDNKEDAEDDEDSMDEETRKRMEIRARMAKMSGGMGMPGMFGGMPLPGATPVKKPKEKKPSEDAAPTSPPPQQRIPMIPVPGLQRVQSPESEITHQAERGATAGNEGDDDPLPPPRRSTAEDRGPPPPIPKESRPQPERGAPPPVPSSAQTSRTSTIDTRPVPQPPPHATPLSPGPGSESDDEASVRNLGSTAETPLAETAVPLPIRNPSVRGTPSIPGSENARSPEGNRASYFGLDSQSTTSDKRASRAPPPVPGSPLIAARPPPPPPPAAPSRATTDLQAGENERESEYEGDYDTDIASSAKHKDALKAGTHVREASLTDNNSMGDPTLRSPPPPPHGTAPRSVPPPPSAPTSAGPKTPASMDAPRAPPPIPPTATRVPVPGDDDYDPYRYDSSRGPPPPVPGAVSIAAPPLPPPRQPEPESSADDDDDLYSKTPPRKSFEAPPRAVPAPPPAQPPPPARVAPRESLDVQRSNTISRRSMDQSRPSMDNAYIARDLDLAESTTWWTASQPLPPSLQNRQGVDILSESEQSTASKRGGRKEVSKEIYILYIDYSQTIISVRFDANNPADAQIEQQHRPPPPKPRQDQLETYWQRFGRNIAETVNALGHAKKDTSVGNASPAALPAELIKGNQQALQPVGNRAYGALVYANLANASTQQHDEIRPGDILTLRNTRFEGTHGTMKHKYKQEYGSMHVAIVEEWDGTRRAIRAWEQGREKQKVRSEKFRLGDLRSGEVKVWRVVGRDWVEWETSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1QE72</accession>
    <name>N1QE72_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Queuosine 5'-phosphate N-glycosylase/hydrolase</fullName>
            <ecNumber evidence="6">3.2.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4 6">Queuosine-nucleotide N-glycosylase/hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_151305</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the hydrolysis of queuosine 5'-phosphate, releasing the nucleobase queuine (q). Is required for salvage of queuine from exogenous queuosine (Q) that is imported and then converted to queuosine 5'-phosphate intracellularly.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>queuosine 5'-phosphate + H2O = queuine + D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:75387"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17433"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:194371"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5 6">
            <dbReference type="Rhea" id="RHEA:75388"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the QNG1 protein family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="6"/>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757308.1">
        <property type="nucleotide sequence ID" value="XM_016906734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QE72"/>
    <dbReference type="STRING" id="692275.N1QE72"/>
    <dbReference type="GeneID" id="27903871"/>
    <dbReference type="eggNOG" id="KOG2524">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036001_2_1_1"/>
    <dbReference type="OMA" id="FSFWSEE"/>
    <dbReference type="OrthoDB" id="416777at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019438">
        <property type="entry name" value="Q_salvage"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21314:SF0">
        <property type="entry name" value="QUEUOSINE 5'-PHOSPHATE N-GLYCOSYLASE_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21314">
        <property type="entry name" value="QUEUOSINE 5'-PHOSPHATE N-GLYCOSYLASE_HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10343">
        <property type="entry name" value="Q_salvage"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="194"/>
            <end position="306"/>
        </location>
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        <location>
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            <end position="215"/>
        </location>
    </feature>
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        <location>
            <begin position="249"/>
            <end position="262"/>
        </location>
    </feature>
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        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF09187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="534" mass="59754" checksum="5668811431015B4B" modified="2013-06-26" version="1">MSDDEVDLELLNLLRQRLGISAPQDGVPRDTGILKNAEFIYSNAIDVHVDMYGTKSAAMQIYKAMQDRAYSTQTWTTHELHPKPSEGFSELDMVNFIFAMDLLNFSFWSELSPQDRFQVEYRGQRWTGYNSLVACLRRALDEDIPFTTPRFWTAPRCTGDVFAHVFRSATAEPIPLLQERIDVLREASTVLRESFADEDDDDDDDDDVNGEDDFLEASKDTIVVTGSSATAGPAPPTECSDQSLDTDLDNPRDPNDDRRAEQDSSLNPTVNGHSGMERSSHPSSQPTEAPALNNLPEIDSAPLGAIDHMDNDALSTVLVDTSTSAPPVTDVSVENKEADAVSSESSTLALNLSPADLRPDHAVLHLIQEADQSAGKLVNLLAKHFNCFRDETRFDGRKVRILKRAQIFVADLWAALNDTGPGHFEDIDHLTMFADYRVPQSLHSLGVLTFSPPLDYHIRDLKRLEPGHSWEVQLRGCSIWAVELIRREILRAHPDATTSINAVLIDFFLYDLAKEREAQGQPAIPHHRTRSIWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1QE73</accession>
    <name>N1QE73_SPHMS</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_119174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016901483.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="27898620"/>
    <dbReference type="HOGENOM" id="CLU_2361068_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF10640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="96" mass="10364" checksum="8C8CCC4CAA535CCD" modified="2013-06-26" version="1">MEKTKMKKTKTKTKVTKPKKGEGQNNKTSIWIMRSQIMGTGGYNPRDHAPPPSTRRKKAELTAVPACCATSTLAAMFHLLGGSASNSASISRFQPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1QED5</accession>
    <name>N1QED5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">FMN-dependent alpha-hydroxy acid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_49906</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="692275.N1QED5"/>
    <dbReference type="GeneID" id="27906277"/>
    <dbReference type="eggNOG" id="KOG0538">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020639_0_1_1"/>
    <dbReference type="OMA" id="WFQLYWL"/>
    <dbReference type="OrthoDB" id="25826at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FMN dependent dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037350">
        <property type="entry name" value="LMO_FMN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF143">
        <property type="entry name" value="FMN-DEPENDENT ALPHA-HYDROXY ACID DEHYDROGENASE PB1A11.03"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 7" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="9">
        <location>
            <begin position="38"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="312"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="118"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="343"/>
            <end position="347"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="366"/>
            <end position="367"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF10715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="420" mass="45550" checksum="1A2F7AA32378D924" modified="2013-06-26" version="1">MAHRVAGGVAYRSSGPPKAPTDPVEYEQKIYQRGLQYERPSLSFQPHRWEEEAAQRMSAETKGYVMGNAGQGETQQKNKKAFAKWSIVPKRLVKTTKLPDLSTTVLGTKQPFPIAVAPVGVQQIMNPDGEVASARAAAQEGVPYIMSTASSTSIEDVAKANGDGVRWFQLYWPSQDKKDITISMLSRAKSSGFSALFVTLDTYILGWRPSDMDNGYNPFLRSDSVGVAIGFSDPVFRSQFKSQHGVEVEEDLHTAAAEWTKTIFPGFSHAWEDIAFLKEHWDGPIVLKGIQTVEDALKAVEVGVQGIVVSNHGGRQVDGGVSSLGVLPRIVDAAGDKIDIFFDSGIRCGADIAKALALGAKSCLIGRPFVYGLALGGEEGVSHVLKSLLGDLELTLHLAGIESSSPEHLNRKVLIREDQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>N1QEF8</accession>
    <name>N1QEF8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cystathionine beta-lyase</fullName>
            <ecNumber evidence="3">4.4.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cysteine-S-conjugate beta-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SEPMUDRAFT_150758</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L,L-cystathionine + H2O = L-homocysteine + pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13965"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:18121"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29256"/>
            <dbReference type="ChEBI" id="CHEBI:58717"/>
            <dbReference type="EC" id="4.4.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homocysteine from L-cystathionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.13" evidence="3"/>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758876.1">
        <property type="nucleotide sequence ID" value="XM_016906379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QEF8"/>
    <dbReference type="STRING" id="692275.N1QEF8"/>
    <dbReference type="GeneID" id="27903516"/>
    <dbReference type="eggNOG" id="KOG0053">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018986_2_1_1"/>
    <dbReference type="OMA" id="NCIGATG"/>
    <dbReference type="OrthoDB" id="2545919at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047804">
        <property type="term" value="F:cysteine-S-conjugate beta-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000013">
        <property type="entry name" value="Cystathionine beta-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000009">
        <property type="entry name" value="Cystathionine gamma-synthase homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006238">
        <property type="entry name" value="Cys_b_lyase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01329">
        <property type="entry name" value="cysta_beta_ly_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF50">
        <property type="entry name" value="CYSTATHIONINE BETA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5 13 14" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="13">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EMF10755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="447" mass="47988" checksum="66E6934D1203A294" modified="2013-06-26" version="1">MSGDTPTNGTGKALNVQKLDLDGHDLPPSPAPSSPRNGRRYNFATELVYTETNDQYSASSMPIYQSATFKGGPGQEYDYTRSGNPTRTHLERHMAKIMGANRALVAGSGMGALDVITRILKPGDEVVTGDDLYGGTNRLLTFLKEHGGVTVKHVDTTTLDSVKSALSEKTTMVLLESPTNPLIKICDINGIASAAHAISPKIVVVVDNTMLSPYLQNPLDLGADVVYESGTKYLSGHHDVMAGVIGVNDVALGDKFYFMINSTGCGLAPFDSWLLLRGVKTLAIRMDKQQANTQAIAEFLENHGFKVRYPGLKSHPQYKLHWSQARGAGAVLSFETGSIALSERIVESTKLFGISVSFGCVNSLISMPCRMSHASIDPATRKERALPEDIIRLCIGIEDLEDLLDDLSQALVRAGAVKLTGAEGFRALTAEETAGASGMTTQVVDEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>N1QEZ1</accession>
    <name>N1QEZ1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 16">Elongator complex protein 3</fullName>
            <ecNumber evidence="16">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">SEPMUDRAFT_149651</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>uridine(34) in tRNA + acetyl-CoA + S-adenosyl-L-methionine + H2O = 5-(carboxymethyl)uridine(34) in tRNA + 5'-deoxyadenosine + L-methionine + CoA + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:61020"/>
            <dbReference type="Rhea" id="RHEA-COMP:10407"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74882"/>
            <dbReference type="EC" id="2.3.1.311"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:61021"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16 17">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="16 17">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the ELP3 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="16"/>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759879.1">
        <property type="nucleotide sequence ID" value="XM_016905688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QEZ1"/>
    <dbReference type="STRING" id="692275.N1QEZ1"/>
    <dbReference type="GeneID" id="27902825"/>
    <dbReference type="eggNOG" id="KOG2535">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025983_2_1_1"/>
    <dbReference type="OMA" id="TFETRPD"/>
    <dbReference type="OrthoDB" id="10265243at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106261">
        <property type="term" value="F:tRNA uridine(34) acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140018">
        <property type="term" value="P:regulation of cytoplasmic translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000003">
        <property type="entry name" value="Elongator complex protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039661">
        <property type="entry name" value="ELP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034687">
        <property type="entry name" value="ELP3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056591">
        <property type="entry name" value="ELP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032432">
        <property type="entry name" value="Radical_SAM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01211">
        <property type="entry name" value="ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135:SF0">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23613">
        <property type="entry name" value="ELP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16199">
        <property type="entry name" value="Radical_SAM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005669">
        <property type="entry name" value="Hist_AcTrfase_ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01086">
        <property type="entry name" value="elongater_protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00344">
        <property type="entry name" value="ELP3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="14 16" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11 17" id="KW-0408">Iron</keyword>
    <keyword evidence="12 16 17" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 16" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 16 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 16" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="5 16" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="18">
        <location>
            <begin position="414"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR005669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR005669-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EMF11758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="577" mass="65853" checksum="67109F6BD0410BF7" modified="2013-06-26" version="1">MTETQTRHKRLPKAVREKLPPENERYVRCCADIANYLVEDFEASQQPDAKKKDLNLNSLRGSFSKKHYLSRQPPLTDIIAAVPEQYKKYILPKLIAKPIRSASGIAVVAVMCKPHRCPHIAYTGNICVYCPGGPDSDFEYSTQSYTGYEPTSMRAIRARYDPFEQARGRVDQIRNLGHSVDKVEYIIMGGTFMSLSPKYRETFISQLHNALSGYSTSQVDEAVLAGEQSTTKCVGITIETRPDYCLPPHLSDMLRYGCTRLEVGVQSLYEDVARDTNRGHTVKAVCETFCQSKDAGFKVVSHMMPDLPNVGLERDLFQFQEYFSNPAFRTDGLKIYPTLVIRGTGLYELWRTGRYKNYTPNVLIDIVARILALIPPWTRIYRVQRDIPMPLVTSGVENGNLRELALARMKDFGTTCRDVRTREVGINEVKHKIRPNQVELVRRDYVANGGWETFLAYEDPKQDILIALLRLRKCSEKYTYREELTGQQSSLVRELHVYGSAVPIHERVKGKSQHQGYGTLLMQEAERIARDEHGSKKIAIISGVGVRGYYRRLGYWLDGPYMSKWLEPEDESDESDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFP1</accession>
    <name>N1QFP1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">E3 ubiquitin-protein ligase PEP5</fullName>
            <ecNumber evidence="9">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_151389</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex. Component of the class C core vacuole/endosome tethering (CORVET) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Vacuole membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the VPS11 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="9"/>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757439.1">
        <property type="nucleotide sequence ID" value="XM_016906784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QFP1"/>
    <dbReference type="STRING" id="692275.N1QFP1"/>
    <dbReference type="GeneID" id="27903921"/>
    <dbReference type="eggNOG" id="KOG2114">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001287_0_0_1"/>
    <dbReference type="OMA" id="ENENECP"/>
    <dbReference type="OrthoDB" id="26184at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033263">
        <property type="term" value="C:CORVET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048284">
        <property type="term" value="P:organelle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16688">
        <property type="entry name" value="RING-H2_Vps11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000440">
        <property type="entry name" value="E3 ubiquitin-protein ligase PEP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057308">
        <property type="entry name" value="CHCR_PEP5_VPS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057307">
        <property type="entry name" value="PEP5_VPS11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016528">
        <property type="entry name" value="VPS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024763">
        <property type="entry name" value="VPS11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323:SF24">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23341">
        <property type="entry name" value="PEP5_VPS11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23356">
        <property type="entry name" value="TPR_PEP5_VPS11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12451">
        <property type="entry name" value="VPS11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17122">
        <property type="entry name" value="zf-C3H2C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007860">
        <property type="entry name" value="VPS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0926">Vacuole</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="CHCR" evidence="11">
        <location>
            <begin position="405"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="886"/>
            <end position="930"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR007860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF09318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="987" mass="109983" checksum="F550F1CA58F4A633" modified="2013-06-26" version="1">MPIAPTAWKLFHFFDVSPVRLPEGDASLSLEQASIGTVTSGKANVFVGTPTGHVHLLDHAFKSVRSWKAHDAGSVTHITQVHDTSYLITLAETLQHEPELKVWTLDQTEKKTGFPRCLCTLTVQNGRKNFPVSAFAVTSDLVQLAVGFGNGAVTVVRGDLIHDRGTKQRTVFESEEPITGLAFREASTTALYIATVSKILALAISGKAQGTPARTLDDHGCAVGCMTLDPESNEVIVAREDAIYSYGPKGKASSFACQGAKKLVNVHKDYMLVASPPANNFGQASKLGAFRTARADEIFNTSTFSILNADLKFTAYSKPISSQIHKVFTIWGDIFLLTIDGKLYRYHEKTFQQKLEELYSRKEYLLAIMLAKKYNIDAVQQNVIFRKYGDYLYQRGDYDTAMQQYLRAIDNTEPSQIIRKFLDNQRIRNLIDYLEELHEHNKATSDHTTLLLNCYAKLKDVDKLEEFIKQPGELKFDLDTAIVMCRQGHYYDQAAFLARRHEEHGLVIDILIEDLKKYAEALAYIVRLEPKEAYPNFMKYGTVLLAHCPAEATQLFTEYFTGVFKPKKDAVIVQETPVAQQSSGFGSTMASSAASAAQNLAALIPLPYMNTSTVQTPKNGDEPATVQQAQVVESLTEGEYVEYEVPKPRVAFPAFIDHPDQFITFLDACINSDGVKAEHRADLHTTLFEMYLHKAGTSKDADEKTEWEQKAKKLIEERNGPIDTSNVLLLSDLEKFREGTILVSEQQGLRFDVFRSYTAAYDTQGAIKALRKYGPEEPQLYPAALAYFTSTPQVLDAAGDEVDVVLRKIDEDGLMAPLQVIQTLSANAVATMGLVKRYLSLTVQRERAEIESNRKLISSYRTDTIAKQNEITELSTKPQSFSQTRCSSCGATLDLPTVHFLCKHSFHQRCLNVPEGIDIKNDVEIECPICAPQNAIVRQTREAQMESASRHDLFDSSLQNPGEGGRFGVIGDWFGRGVMSASVNHDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFW3</accession>
    <name>N1QFW3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GABA-specific permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_119181</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758768.1">
        <property type="nucleotide sequence ID" value="XM_016901484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QFW3"/>
    <dbReference type="STRING" id="692275.N1QFW3"/>
    <dbReference type="GeneID" id="27898621"/>
    <dbReference type="eggNOG" id="KOG1289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004495_6_1_1"/>
    <dbReference type="OMA" id="PSEMNWS"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF2">
        <property type="entry name" value="ACID PERMEASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="417"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="464"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="495"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF10647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="531" mass="58086" checksum="757D40B355077869" modified="2013-06-26" version="1">MAQRKPFAIGKEEDASYIVAVDETLTLTDLPPEKKGTVDDRRDMHRMGKAQEFRRNFSFIPIFGFAATLMMTWASVLSSASYVLPNGGLPAMIWMYLVTLVGFGCAIFCMAEMASMAPTSGGQYHWVSEFAPKSFQKLLSYIVGWFCVLGWQAGIAGQCFTVATQVQGLIILNDSTYVPQRWHGVLLTIAAASVAVLFNTVFARKLPLLEGLMLIILICGFFAILIPLWVFAPRQSNSAVWTEFTQTAEWPSMGVATLVALTGPIYALIGPDSAVHMSEEVRDASLTIPLAMISTLVLNGLTGLVMAITFVYCIGPIDAALLPQYNFAFIGTFYNATQSRAGATVMTCIITTLTLCSAIGNLATGSRQIFAFARDQGLPFAKVLSYVQPGWDIPLNAVVFCFVSTALLSLINLGSIVAFNAILSLGVVALLTSYLTSMGCIFIKRVRGEELLPRRFDLGVPLGWFTNVVGLIYIMLAYIFAFFPLYNNPMLETMNWASCVYGGVGVVATVYYIFYARHVYVPPVSRLAKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1QG21</accession>
    <name>N1QG21_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">40S ribosomal protein S13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_150728</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758833.1">
        <property type="nucleotide sequence ID" value="XM_016906359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QG21"/>
    <dbReference type="STRING" id="692275.N1QG21"/>
    <dbReference type="GeneID" id="27903496"/>
    <dbReference type="eggNOG" id="KOG0400">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090139_2_0_1"/>
    <dbReference type="OMA" id="MHTRRKG"/>
    <dbReference type="OrthoDB" id="623277at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.10:FF:000003">
        <property type="entry name" value="40S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.130:FF:000001">
        <property type="entry name" value="40S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_A">
        <property type="entry name" value="Ribosomal_uS15_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_uS15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023029">
        <property type="entry name" value="Ribosomal_uS15_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012606">
        <property type="entry name" value="Ribosomal_uS15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006331">
        <property type="entry name" value="PRK08561.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885">
        <property type="entry name" value="RIBOSOMAL PROTEIN S15P/S13E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885:SF6">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08069">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01386">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS15 N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF10712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="151" mass="16708" checksum="32D0734BC7DA2CD2" modified="2013-06-26" version="1">MGRLHSNGKGISASAIPYSRAPPAWLKTTPDQVVDQICKLAKKGATPSQIGVVLRDSHGVAQVKVVTGNKILRILKGNGLAPEIPEDLYMLIKKAVAVRKHLERNRKDKDSKFRLILIESRIHRLSRYYKTVGALPPTWRYESATASTLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1QG68</accession>
    <name>N1QG68_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_150794</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758923.1">
        <property type="nucleotide sequence ID" value="XM_016906401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QG68"/>
    <dbReference type="STRING" id="692275.N1QG68"/>
    <dbReference type="GeneID" id="27903538"/>
    <dbReference type="eggNOG" id="ENOG502T80E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_589459_0_0_1"/>
    <dbReference type="OrthoDB" id="3647936at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="242"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="200"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="219"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF10802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="464" mass="50072" checksum="934938BB7C93A000" modified="2013-06-26" version="1">MADMVQLVEPGTPHAHGHHAKRDTGLLGQDFEDELVGYNFNPPFAAAAYDDVNAEDSELRQYIRHDALEIPLSSPPALTLSTGPSPSTSYIGFPIAERPISPITPPDPTCEPRCSATPSSDSNSDVDFGFEDLIKPEAYQTGTGVPLAKTNASTASRPLRAPSPRLPCGTCNGVSAHAAHSQQPSVAERPSLTVVPSAADQGASLVHPTRSLSKRGRTDTNGTMSGLVKQNSKRHKQVPNGFPCREGCGHVFSRSCDEKKHYGRTHAPEEEKKHSCPECNMSGKIKRFLYPKDVARHLKQVHHVQPSETPIAGSIATGDVLDHASPASSTTTSTTFPGTAGFWTLHKAVLRFKNLRISSKSPRSPDEQEDKCIMVSTGDRTFVEVDVAGVTQTDTLTHRILTALKISQGSHENHVLAQVYSRRGGRTHLGAHVNMRGLLHLVSTTADSQGTLKLIINNNTARVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1QG85</accession>
    <name>N1QG85_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_118260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760449.1">
        <property type="nucleotide sequence ID" value="XM_016901410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QG85"/>
    <dbReference type="GeneID" id="27898547"/>
    <dbReference type="HOGENOM" id="CLU_1670484_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF12328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="158" mass="17406" checksum="3DCE7D3E329702C1" modified="2013-06-26" version="1">MPNAQCPDFCHWPEYEGIGLPRATRLSTSSTSSSILYSRNAKFSEHDVSARILVTLSREQNVSLAPPPAKNNVTKDNSDETDWKKLPLHSAIVQHATEKSLKTAIGRVSDPAALPTSSPAPSTFTDGLPLLNFIVLDLDYTLWAFDINNPRWTTGLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGJ8</accession>
    <name>N1QGJ8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Lariat debranching enzyme C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SEPMUDRAFT_72605</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the lariat debranching enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757799.1">
        <property type="nucleotide sequence ID" value="XM_016909999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGJ8"/>
    <dbReference type="STRING" id="692275.N1QGJ8"/>
    <dbReference type="GeneID" id="27907136"/>
    <dbReference type="eggNOG" id="KOG2863">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005893_1_0_1"/>
    <dbReference type="OMA" id="TDYGDWK"/>
    <dbReference type="OrthoDB" id="407609at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008419">
        <property type="term" value="F:RNA lariat debranching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00844">
        <property type="entry name" value="MPP_Dbr1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000035">
        <property type="entry name" value="Lariat debranching enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007708">
        <property type="entry name" value="DBR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041816">
        <property type="entry name" value="Dbr1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849:SF0">
        <property type="entry name" value="LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849">
        <property type="entry name" value="RNA LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05011">
        <property type="entry name" value="DBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01124">
        <property type="entry name" value="DBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lariat debranching enzyme C-terminal" evidence="14">
        <location>
            <begin position="246"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="407"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="433"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMF09678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="455" mass="51765" checksum="3C60FB99EB2DE914" modified="2013-06-26" version="1">MAVQLEESHGVRLAVEGCGHGTLHAIYASIEEACKQKNWPGIDLLIIGGDFQSVRNAFDLNCVSMPPKYREMCDFHEYYSGQRTAPYLTVFVGGNHEASNYLFELYHGGWVAPNIYYMGAANILRLGPLRIAGMSGIWKGFDYRKPHFERLPYNESDMKSIYHVRELDVRKLLQVRTQIDIGISHDWPQGIEWKGNWKKLFRMKKHFEDDANSGKLGSVAARQVLELLRPRYWFSAHLHCKFAAPIEHPPDITNTQTSFLALDKCLPSRDFLQLITASEEPIRDQDRPLKLQYDREWLAITRAFALSEPVPVGNPDVRVPLAKTQSDYRKLIEAERKWVDQNIDDAHLMIPENFIVTAPIFDGGNFRDAQYQQVKEYPNPQAIEFCQLLHIPNPFDITEEELSNRLAAGPRPDDFQGGRGGGRGGFRSDRGGRGRGHGRGRGQGRGRGRGGGRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGS7</accession>
    <name>N1QGS7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="14">3.2.1.58</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Exo-1,3-beta-glucanase D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SEPMUDRAFT_137164</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Glucosidase involved in the degradation of cellulosic biomass. Active on lichenan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="14"/>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764506.1">
        <property type="nucleotide sequence ID" value="XM_016902829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGS7"/>
    <dbReference type="STRING" id="692275.N1QGS7"/>
    <dbReference type="GeneID" id="27899966"/>
    <dbReference type="eggNOG" id="ENOG502QRG8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004624_4_2_1"/>
    <dbReference type="OMA" id="TYHEGFL"/>
    <dbReference type="OrthoDB" id="62120at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000033">
        <property type="entry name" value="Glucan 1,3-beta-glucosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF34">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 16" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 16 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="17">
        <location>
            <begin position="87"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMF16385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="451" mass="50510" checksum="67F016AE5D6829B2" modified="2013-06-26" version="1">MGLNSTWDDSTRANDQVPPLNEEFKYGTMPVRGCNVGGWLSIEPFITPSLFSSYKTSDNVVDEWTLTKALGPTNAKSILEKHYSSWVTESTFADLQAAGFDHVRIPFSYWAIITYDGDPYVSQVSWRYLLRGIEWARKYGLRINLDLHGAPGSQNGWNHSGHQGAIGWLNGTDGTLNGDRTIAIHKQLSEFFTQPRYKNIVTMYGLVNEPRMVELDQSTVISWTQSAIDAVRGNNFTGIIVFGDGFMGLDNWQGKLTGNDKLLLDVHQYVIFNVDQIVLNHHDKINFACAGWTQQALRSQNTATGFGPTLCGEWSQADTDCANYLNNVGVGSRWEGTLNMVGTPGGSINGSVLTPTCPTNNNPRCSCDGANADPSDYSDVYKQWLLMFAEAQMHSFEQGWGWFYWTWQTESSAQWSYKAGLKAGTMPQLAYQRSFDCSQEIPDFQNLPEFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>N1QH70</accession>
    <name>N1QH70_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14">Histone acetyltransferase</fullName>
            <ecNumber evidence="3 14">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SEPMUDRAFT_150594</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac. The NuA4 complex is involved in the DNA damage response and is required for chromosome segregation. The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) through homologous recombination. Recruitment to promoters depends on H3K4me. Also acetylates non-histone proteins. In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3 14"/>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758629.1">
        <property type="nucleotide sequence ID" value="XM_016906276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QH70"/>
    <dbReference type="STRING" id="692275.N1QH70"/>
    <dbReference type="GeneID" id="27903413"/>
    <dbReference type="eggNOG" id="KOG2747">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005327_1_2_1"/>
    <dbReference type="OMA" id="DNAHRQC"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990467">
        <property type="term" value="C:NuA3a histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.60:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF161">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16866">
        <property type="entry name" value="PHD_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="16">
        <location>
            <begin position="125"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="MYST-type HAT" evidence="17">
        <location>
            <begin position="468"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="197"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="352"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="625"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="851"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="15"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="77"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="277"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="313"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="352"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="626"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="851"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="866"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="920"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="976"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1078"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="12">
        <location>
            <position position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMF10508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1110" mass="123321" checksum="806F504B2E1B2EB9" modified="2013-06-26" version="1">MELDENAGAPGEKIGDEEEEEDIEMDDEADAEGEVEEPELGSEADADGEIEDEDDEGEFVGAVKTRSSRARSRRTPEDEESEAYEGNADNESDSASSPAEGSWQAVEDAEDDDDDDDSKLQNVDANRCVFCKQTEENDPSEDFEEYLACAVCGDNAHRQCARDASSLVADQEAAHWRCQDCVANGLEEDFKDVPQMLSSRRRSSAPKMARDLLPQARGGIKPGSHSVFNTLILPDDEMDGSRSLRKRKTPSEDIDETSRTANRKRRKTTPPEEEQPESVPEIVVEPAESIEEDGNEPQQSSSPKARTSRPQRQKKDSLGARIIHRSDNPKSAIIAIPVTVAQFETIEKDVIKKQKRRERDRARRARNSRRTVTAEPEEGPGAAATIPVVQTTMYTNPFFPFHDRNTDENQGKPYGGILTELEADTKRTYPEEADRLAFQAAREKADEEWKQKIARQNGDTPARSKKSAPASKIRCINFGRYEIDTWHAAPYPEEYSRNEHLYICEFCLKYMNSDYVAWRHKLKCSARHPPGDEIYRDNIINPETKQETTLSFFEVDGRRNPLYCQNLCLLAKLFLGSKTLYYDVEPFLFYIMTENDAHGCHFVGYFSKEKRGMGPAAPPMEPWTSFDENAQTTSGASQGLEGTAQDPALQNPGNNVSCILVLPVHMRRGFGRVLIEFSYLLTQVEGRTGSPEKPLSDMGLVSYRSYWRNVLCKLLLRYRDHEDEANASKHLTIVRIAKETGMTPDDIVSTLEGLRALVRDPLTGTYALRLDYDYMREYVDKHEKKATIKIIPKNLCWTPYIMGRPTNLFAMGEETNQPIQTVASRPDETSELPAQPEEGVQQTLQLDKEAEAKDGGTADRAIDVATPTTELPPLTLNGVDASPKSRKKTPPPLTLTPQASFIVEKSKDSPSRRSPRKTPNGNTTTMHIRTKSQQLGSGEATPNSEDSAGSIPTSAGSIPPSRFEVFPPVPGMPQTAKRRANRPSARRTNYRNAYGTPARRKRPDHRNGESPSQARNRRTTSSGGGGGGGKASAAGPSSLRRGRSKLGDTVTVAEADRAMDEGEEEECDTAASKAAAGDDIEDDEADAPGEEIDDEADAPGEEEEEEIQYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1QHA3</accession>
    <name>N1QHA3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dienelactone hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_143201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758659.1">
        <property type="nucleotide sequence ID" value="XM_016903032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QHA3"/>
    <dbReference type="STRING" id="692275.N1QHA3"/>
    <dbReference type="GeneID" id="27900169"/>
    <dbReference type="eggNOG" id="KOG3043">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054590_2_1_1"/>
    <dbReference type="OMA" id="PGKCCFE"/>
    <dbReference type="OrthoDB" id="17560at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF44">
        <property type="entry name" value="PROTEIN AIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="30"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF10538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="258" mass="28184" checksum="A8E04A50984554BB" modified="2013-06-26" version="1">MASNPPGKCCTIGVKHEGKATGSKKDISGVDTYLAYPESRQTDTAILILTDVIGHDFINAQLIADQFAANGYFVVMPDLFEGDPMPLNRPDDFDIMKWLATSGPSKGHTTKQVDPIVAKVIKALKADFGVKKLGSVGYCFGAKYVARYMAKDQGIDVGYVAHPSFVDAEEIKALTGPFSIAAAETDQIFPAEKRRETEDILKDMEIPYQISLYSDVEHGFAVRADTSKAPVKFAKEAAFLQAVAWFDEFLKGSRSWAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1QHA5</accession>
    <name>N1QHA5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HIT-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_151434</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HIT family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757525.1">
        <property type="nucleotide sequence ID" value="XM_016906821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QHA5"/>
    <dbReference type="STRING" id="692275.N1QHA5"/>
    <dbReference type="GeneID" id="27903958"/>
    <dbReference type="eggNOG" id="KOG3969">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041045_3_0_1"/>
    <dbReference type="OMA" id="HVHINPI"/>
    <dbReference type="OrthoDB" id="10264956at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140932">
        <property type="term" value="F:5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000016">
        <property type="entry name" value="Scavenger mRNA decapping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.40">
        <property type="entry name" value="Scavenger mRNA decapping enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008594">
        <property type="entry name" value="DcpS/DCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011145">
        <property type="entry name" value="Scavenger_mRNA_decap_enz_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12978">
        <property type="entry name" value="HISTIDINE TRIAD HIT PROTEIN MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12978:SF0">
        <property type="entry name" value="M7GPPPX DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05652">
        <property type="entry name" value="DcpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11969">
        <property type="entry name" value="DcpS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028973">
        <property type="entry name" value="Scavenger_mRNA_decap_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102860">
        <property type="entry name" value="mRNA decapping enzyme DcpS N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR028973-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF09404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="247" mass="28876" checksum="3820838CF428F932" modified="2013-06-26" version="1">MANASASMDTQAQTPPPDLKINLIWPATEKHFKKYSFQQMRVVTETPEIYEKFVRPYMSLCREEGQLNWVLNILEGRKEQENVLYRSKEQDVKDDFLLLPDLNWDRKTIGSLHLLALVERRDIWSVRDLKQKDAAWLRLLRKTITDATVKLYPGVEIDMLKFYIHYQPTYYHFHIHVVHVDLDATGTQAVGKALGLDNIISQLEWMRDGEQSGMHQVELSYTVGEESELWQKIYLPLKKGTEPEIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1QHI4</accession>
    <name>N1QHI4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_112690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764771.1">
        <property type="nucleotide sequence ID" value="XM_016900992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QHI4"/>
    <dbReference type="STRING" id="692275.N1QHI4"/>
    <dbReference type="GeneID" id="27898129"/>
    <dbReference type="eggNOG" id="ENOG502RGI2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_519878_0_0_1"/>
    <dbReference type="OrthoDB" id="3940204at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF16650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="524" mass="56952" checksum="F9B9850128375B3A" modified="2013-06-26" version="1">MAPRVPSRKDPVDKESPRKSPKKTTGRPSSKPKQTAAEARAEQDIDAEPRATRSKNSQSSSTSNLKAASPTKVTKNKRKESSKIKKTSKPAHDKAVDDGASGSEKSKESATAVAKKSKKVATSDAGGPAKDKKPRGRPPGKKTPASSYQDLLKVINKAAYEAVLGGGIEALTAYQDYHSNASIAENDYVNATNAGAMAAIKEALEHQRLKKSARLQDDSSGQTHVEAGRRRHLTQAAIAATRLDEALPGIKIMKKKKMPQARKKKAVPAITPPVSPTKANLKAQMERQRADELKLRNQLLRSGLPVSSATTDRDIPLPGLSELSQRGNMISSTNPGIISIMVDDHAQDRINPFFETLPGPEIWYRNMPPFFNFGETKFMEQQISDQINEDLAREHPGPVSRKPPAKPTESIASKVLSPFKGMLGVGGAAPTYQDQPAAAEGEEDADGPPEPKVLRPDQWVLPELSKEEKNALQKKSLMKSGLPDFTQDFQLPGFLREFQSESPNKRRAPPNGSQASPKRGRIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1QHL3</accession>
    <name>N1QHL3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_48440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758769.1">
        <property type="nucleotide sequence ID" value="XM_016909066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QHL3"/>
    <dbReference type="GeneID" id="27906203"/>
    <dbReference type="eggNOG" id="ENOG502SPVV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036632_1_2_1"/>
    <dbReference type="OMA" id="LMSWMVL"/>
    <dbReference type="OrthoDB" id="3897607at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39614">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39614:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="2">
        <location>
            <begin position="36"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF10648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="278" mass="30589" checksum="CAC30658AFDB2757" modified="2013-06-26" version="1" fragment="single">MNSGPRNFITTEQDHGGIALTICTLMATWVVLCFGVRIYMRATVSGPFGIDDIIFTAATLFGIFHAIVSSTAIISFGMGKSLVLLTGSQIIHAQKAVYAADLIYFIVNALTKCTVALLLARIVFVRRRVYACYGVVVLAFLWGVISLIVGGFQCSEHPGWKIVGERCDNFLLSWRVVTAFDVLIEVFIFAIPVWVVWDLHSNIKKKMTVIAVFAFRLPVIAAAILQIHYLSYAIESGDPLLHGVSAFICRNVELHWGLISATIPTLKPFMAAFNTNLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1QHY6</accession>
    <name>N1QHY6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_111051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757715.1">
        <property type="nucleotide sequence ID" value="XM_016900893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QHY6"/>
    <dbReference type="GeneID" id="27898030"/>
    <dbReference type="HOGENOM" id="CLU_1125123_0_0_1"/>
    <dbReference type="OrthoDB" id="10577458at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="247" mass="28513" checksum="A57B0CC7D1D7E72D" modified="2013-06-26" version="1">MPKVHRRPYSIHAREPELYQSFPGESMQDEGRWVRQHEKFGQSRERAGATASCQPREVYQASGSRISVLPRRRTAFPRAAPANLSNEECSTRTVTPVKSEVTQIKQEPETPFYAGRPYSRRRRPELPSTWRKNPWAKQLYGRTLPKPKRPREGRIRWNDTFRLGLKLIKQEFASDWSGRETAQLFSDTFATELVDMGVKLPVAYGRLSWQYSHYLNGVGVQASWDRVAAADLTTVVALRRRIRAAQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1QIF4</accession>
    <name>N1QIF4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cora-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_129854</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765137.1">
        <property type="nucleotide sequence ID" value="XM_016902313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QIF4"/>
    <dbReference type="STRING" id="692275.N1QIF4"/>
    <dbReference type="GeneID" id="27899450"/>
    <dbReference type="eggNOG" id="ENOG502QVFZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015119_2_0_1"/>
    <dbReference type="OMA" id="LHTENGY"/>
    <dbReference type="OrthoDB" id="165352at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015087">
        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494:SF1">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="455"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF17016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="501" mass="55797" checksum="716A0E352770BD71" modified="2013-06-26" version="1">MKWRRALPINVTSVPRTGARPRSLGLGLGLGLVTTPAPHVFQQRPTLTTFTFTSSRPQLKPLHYRPFHTRHGLQSAAGAEPGLSSYAGCTSPQAQHCQIKIIDYSKTRLEENHVNSLELDAFLRDRPKPGWAAARWIWVNSISLDVIQCLGRSKGLHPLAIEDVMDTHATTKVDWYDNHCFVEMNLVQLAHEGSNTIRRGSHARNEVKERKSRRTLVPGRFGMSVEQVSAFLTSDNTIITIFEHSGEDVLAPIMLRLRSPQTVVRSSGDPSMLLQAVIDAVVDLSLPIGIAASEAFDDLEQDVLENPTIGQSKQLHILRSGLTQLMENANAIAILVRTLCDHGSIPGSRRRLEEGSPDSILVQQLNTSVVISPTTQIYLRDVQDHVTALSNNTRTSIRSAENLSSLIFNTIAASQNESVRSLTLVSSFFLPLTFLTGYFGMNFEPMWATNNHSDAFFWLIATPVMLTTMTILMRARSKVNRRQQWITQGQQANVAPRRLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1QIS0</accession>
    <name>N1QIS0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Molybdopterin binding oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_69643</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758600.1">
        <property type="nucleotide sequence ID" value="XM_016909869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QIS0"/>
    <dbReference type="STRING" id="692275.N1QIS0"/>
    <dbReference type="GeneID" id="27907006"/>
    <dbReference type="eggNOG" id="KOG0535">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030575_0_0_1"/>
    <dbReference type="OMA" id="GHVWYAV"/>
    <dbReference type="OrthoDB" id="10051395at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008482">
        <property type="term" value="F:sulfite oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02110">
        <property type="entry name" value="SO_family_Moco_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.420.10:FF:000002">
        <property type="entry name" value="sulfite oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="entry name" value="Oxidoreductase, molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005066">
        <property type="entry name" value="MoCF_OxRdtse_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008335">
        <property type="entry name" value="Mopterin_OxRdtase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372:SF6">
        <property type="entry name" value="SULFITE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372">
        <property type="entry name" value="SULFITE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03404">
        <property type="entry name" value="Mo-co_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00407">
        <property type="entry name" value="EUMOPTERIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="Oxidoreductase molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase molybdopterin-binding" evidence="6">
        <location>
            <begin position="165"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Moybdenum cofactor oxidoreductase dimerisation" evidence="7">
        <location>
            <begin position="376"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF10479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="553" mass="63181" checksum="97E0355AA2B57758" modified="2013-06-26" version="1">MTVPNASPRDVVASQPHTTHGVGTKVILPNSGSIHDFPVDKTDFPTFPEERAGWKGYVEWEKYPEKRAECERILAQYKFPSPPEFQLQPLPKTNPVLEGVRWKQYHYACGPTLRDIPDISWKYVQEEKSADMIHVLQFPYNGEPPRKRLVETEITSNRDFFVRNHGGIPEIEEDAFELDIEGLVKNPMKLTLADLKNESLFPKRSHVVSLQCSGTRRIEQINQYPGDGDELINAPWGEGAIGNARWGGVYLKDVIAHCGGLSDPSAENDIHLEFFGADTYFKKGKVYNYVVSVPYRKVKFEEVMLAWEMNGVPLPKIHGFPLRTVVFGYIGARSCKWLYKIRAIRGPSQAPVQKKEYLYYTPQLGKQNVQYSNGFSIQDMPVSSAIMTPVDMDQIIHDGTIKLTGWAYSGGTGGHWPQRVEVSADGGSVWYEVPFENLSKKYYYGWRTWHIEMPVDAEGWLEFCCRTWDNANNTQPTYVRSAWNFDLHVTSSCHRVKIYSINRSHPATARRLQQLEEVGASILPITQPLPFDLETDEHYEAEMEARDGRDPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1QIS4</accession>
    <name>N1QIS4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_150577</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat MET30/SCONB/SCON-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758605.1">
        <property type="nucleotide sequence ID" value="XM_016906267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QIS4"/>
    <dbReference type="STRING" id="692275.N1QIS4"/>
    <dbReference type="GeneID" id="27903404"/>
    <dbReference type="eggNOG" id="KOG0274">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_103_3_1"/>
    <dbReference type="OMA" id="TMCRAAQ"/>
    <dbReference type="OrthoDB" id="190105at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0010992">
        <property type="term" value="P:ubiquitin recycling"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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        <property type="entry name" value="F-BOX_WD REPEAT-CONTAINING PROTEIN 7"/>
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        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="WD_REPEATS_REGION"/>
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    </dbReference>
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        <location>
            <begin position="501"/>
            <end position="548"/>
        </location>
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            <begin position="753"/>
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        </location>
    </feature>
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        </location>
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        </location>
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        </location>
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            <begin position="991"/>
            <end position="1029"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="413"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="571"/>
            <end position="649"/>
        </location>
    </feature>
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        <location>
            <begin position="156"/>
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        </location>
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            <begin position="203"/>
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            <begin position="213"/>
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        </location>
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            <begin position="283"/>
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        </location>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00007968"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMF10484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1108" mass="121890" checksum="56037A465A886255" modified="2013-06-26" version="1">METTRHIGLGLHEQGGPSYPPEAILSTAPASPTDDRMANHGDTREHNTNIIATMPPEHSTMAQISFGPATQQTVTTVTTTTTVSLPPLIMKPPKDLHDRDPKQYPLAYSPTPSSIKKFCFDVNGRSTAFHEPEDPIETLQRHRALQARIQRSKGFIRQEEKHDDYETPLHSRQLQSKKPSNSLKRSATPVSIAEAAELASVQRKTKKQRSSLHRTYSETTELPSLDERSGSRPSQQPRNPSHPSPVTPDTDVVGALPRAASSRLGANKGKAGSKPSHSRVQELQDDSQDTQMADGEDVDEDDSEMSLGGQHSSRNARKGQDATNWATQRADATATPPIADTDLMPAPRAEESRRPHLPGIMTNSQQDASLPSPSLSPITAAANLASRQNAFDLSFGDHNEETASVVSGLDLDDDSKTHSAKSFDSQQYTHSSGKERYRFTPSCSSQSAPAGPTIMDIPTMVDAFDAMPESMQTYVMYQFLRRCAKPTLQMVATVVNPALKCDPFNILPAELGLNITRFLDAQSMCRAAQVSRRWRKLINSDEKAWKDLLERDGYTLPDGEIARAVREGWGWQHPGEQGYEEDLSKPLPASPEPAEDPVSEDELTASSTVTSRDRRKKVMKPSSSKKSRRRPIHSSSSITKPTPTPNSKWLKLLGTAKGANAFAHAATQAVPQPRIGLDSLSNMHLFKSLYQRHYLIRKAWMNEEAQPQHLAFRAHHRHVVTCLLFDSDKILTGSDDTKINVYDTKTGALRNRLEGHEGGVWALQYDGDILVSGSTDRSVRVWDIKSGRCLQVFQGHTSTVRCLVILQPVQIGTEADGTPIIFPKEPLIITGSRDSTLRVWKLPKANERGIFHAGPPANDHDNPYFLRTLSGHHNSVRAIAAHGDTLVSGSYDCTVRVWKISNGDLVHRLQGHTQKVYSVVLDHARNRCISGSMDNLVKVWDLASGACLFNLEGHTSLVGLLDLSDDRLVSAAADSTLRIWDPENGACKATLSAHTGAITCFQHDGQKVISGSDRTLKMWNVKNGECVRDLLTDLSGVWQVRFDERRCVAAVQRNSLTYIEVLDFGAARDGATAEQCGRRVVVDPRGKEIVDVDIDTTGSVHDEDAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1QIS7</accession>
    <name>N1QIS7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dephospho-CoA kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_150006</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016905907.1"/>
    </dbReference>
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    <dbReference type="STRING" id="692275.N1QIS7"/>
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    <dbReference type="eggNOG" id="KOG3220">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141191_0_0_1"/>
    <dbReference type="OMA" id="RAWEHEQ"/>
    <dbReference type="OrthoDB" id="247245at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02022">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695:SF46">
        <property type="entry name" value="BIFUNCTIONAL COENZYME A SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695">
        <property type="entry name" value="DEPHOSPHO-COA KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
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        <property type="entry name" value="DPCK"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF12314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="158" mass="18160" checksum="CA746AEAADC01094" modified="2013-06-26" version="1">MYKQILYAYLSGSWACVLDVPLLFESGWEPLCGTILVVGVSDPAIQMQRLRARDEHLTEEDAKNRVAAQWDVRDKAKRCLRRGEKAGVVVWNDGDQADLKRQIDAVMSTIRSGSPQWWAWLLLLCPPLAVASGAWHYVRGWWIKRAWEHEQTKEKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1QIV2</accession>
    <name>N1QIV2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mannan endo-1,6-alpha-mannosidase</fullName>
            <ecNumber evidence="4 10">3.2.1.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_150598</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Random hydrolysis of (1-&gt;6)-alpha-D-mannosidic linkages in unbranched (1-&gt;6)-mannans.</text>
            <dbReference type="EC" id="3.2.1.101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 76 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.101" evidence="4 10"/>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758635.1">
        <property type="nucleotide sequence ID" value="XM_016906280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QIV2"/>
    <dbReference type="STRING" id="692275.N1QIV2"/>
    <dbReference type="GeneID" id="27903417"/>
    <dbReference type="eggNOG" id="ENOG502QSWP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025694_1_2_1"/>
    <dbReference type="OMA" id="WAPHTYD"/>
    <dbReference type="OrthoDB" id="4187847at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008496">
        <property type="term" value="F:mannan endo-1,6-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000006">
        <property type="entry name" value="Mannan endo-1,6-alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014480">
        <property type="entry name" value="Mannan-1_6-alpha_mannosidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145:SF41">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016302">
        <property type="entry name" value="Man_a_manosd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 10 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110889" description="Mannan endo-1,6-alpha-mannosidase" evidence="12">
        <location>
            <begin position="20"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR016302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF10514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="452" mass="48772" checksum="676B8A405BB123E8" modified="2013-06-26" version="1">MNIFEIMLCVPLAAHLATTLELDLNDPNSIKNAAKSAAQGMMKWYTGDTMVGGIPGLLPGPYYWWEAGAMFGAIIDYWYYTGDDTYNDRTMKAMQFQIGPDDNYMPPNQSKSLGNDDQAFWGIAALTAAEVNFPNPPAGQPQWLALAQGVFNSQAPRWDTASCAGGLKWQISPLNNGYNYKNSISNGCFFNMAARLGLYTGNSSYLDWAEKTWDWVAGPVGLIDNQSYVFDGSDDTIDCTKVSHLQWSYNAGVFLYGAAVMYNATEGDTRAKWQTRTRGLLTGIVSIFFQNQTMTEVACESGANCNIDQQTFKAYLARWMAASVKVAPWTHETIMPLIRASALAAARSCTGGDDGQTCGTDWLSGEWDGAFGVGQQMSALEVIQSTMIDTVPGPLGNGTGATSTGDPGAGTGGQWDIEVVPNAITTADRVGAGILTATVVGGFVGCFYWMLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJ87</accession>
    <name>N1QJ87_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Polyprenal reductase</fullName>
            <ecNumber evidence="5">1.3.1.94</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_57560</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Plays a key role in early steps of protein N-linked glycosylation by being involved in the conversion of polyprenol into dolichol. Acts as a polyprenal reductase that mediates the reduction of polyprenal into dolichal in a NADP-dependent mechanism. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a di-trans,poly-cis-dolichal + NADP(+) = a di-trans,poly-cis-polyprenal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:80727"/>
            <dbReference type="Rhea" id="RHEA-COMP:19536"/>
            <dbReference type="Rhea" id="RHEA-COMP:19537"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:231623"/>
            <dbReference type="ChEBI" id="CHEBI:231637"/>
            <dbReference type="EC" id="1.3.1.94"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="5">
            <dbReference type="Rhea" id="RHEA:80729"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the steroid 5-alpha reductase family. Polyprenal reductase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.94" evidence="5"/>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765417.1">
        <property type="nucleotide sequence ID" value="XM_016909441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJ87"/>
    <dbReference type="STRING" id="692275.N1QJ87"/>
    <dbReference type="GeneID" id="27906578"/>
    <dbReference type="eggNOG" id="KOG1640">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044409_0_1_1"/>
    <dbReference type="OMA" id="RFYETNF"/>
    <dbReference type="OrthoDB" id="541710at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003865">
        <property type="term" value="F:3-oxo-5-alpha-steroid 4-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160198">
        <property type="term" value="F:polyprenal reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102389">
        <property type="term" value="F:polyprenol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016095">
        <property type="term" value="P:polyprenol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039698">
        <property type="entry name" value="Dfg10/SRD5A3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14624">
        <property type="entry name" value="DFG10 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14624:SF0">
        <property type="entry name" value="POLYPRENOL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="6">
        <location>
            <begin position="200"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF17296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="328" mass="35804" checksum="FC842CDD88C3BFE5" modified="2013-06-26" version="1">MGALLLLRGAYLGAAIVVLLVAAIPALRTRFLSYGARSDDTDATRRTTSTAQNASSPSATRLVTTLLDVLASIRVPHGWFASFYALSVAASLYWAVELISKGPAFTAIARSQLPLQRHSSASASMTVGQVQVAWLMMFLQGTRRLYECLCWSKPSAASMWIGHWALGMLFYLCTSVSIWIEGTAALHNHVFAMQDFTLRAPSLRIFLGVLAYILAAGLQHDCHAYLASLKASRNRRDGSAPSTDYSLPEHPAWNLSLSPHYFAECLIYLAIAIVAAPAHSVCNGTLLCALAFVAINLGVTADGTKKWYARKFGEEHTRSRSRMIPFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJP1</accession>
    <name>N1QJP1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Inositol oxygenase</fullName>
            <ecNumber evidence="4 14">1.13.99.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 14">Myo-inositol oxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SEPMUDRAFT_145735</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 14">
            <text>myo-inositol + O2 = D-glucuronate + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23696"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:58720"/>
            <dbReference type="EC" id="1.13.99.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="13 14">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Polyol metabolism; myo-inositol degradation into D-glucuronate; D-glucuronate from myo-inositol: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the myo-inositol oxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.99.1" evidence="4 14"/>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764623.1">
        <property type="nucleotide sequence ID" value="XM_016903236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJP1"/>
    <dbReference type="STRING" id="692275.N1QJP1"/>
    <dbReference type="GeneID" id="27900373"/>
    <dbReference type="eggNOG" id="KOG1573">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050259_0_1_1"/>
    <dbReference type="OMA" id="RYNTKYG"/>
    <dbReference type="OrthoDB" id="5151075at2759"/>
    <dbReference type="UniPathway" id="UPA00111">
        <property type="reaction ID" value="UER00527"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050113">
        <property type="term" value="F:inositol oxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019310">
        <property type="term" value="P:inositol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007828">
        <property type="entry name" value="Inositol_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12588:SF0">
        <property type="entry name" value="INOSITOL OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12588">
        <property type="entry name" value="MYOINOSITOL OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05153">
        <property type="entry name" value="MIOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="125"/>
            <end position="127"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="181"/>
            <end position="182"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="258"/>
            <end position="259"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR607828-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR607828-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMF16502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="331" mass="38511" checksum="F66B35DD70F18155" modified="2013-06-26" version="1">MAPIAIETPNVAENFHDHKDGLALEATSDAIDEVNVLKAAMRVKNGTATQEEVDIYEKSQFDADKDKTQFRQYEDACDRVKNFYREQHEKQTVAYNLKARNDFKSKTRAEMTIWQAMEKLNTLIDESDPDTSLSQIEHLLQSAEAIRRDGKPKWFQLTGLIHDLGKLLFFYDAQGQWDVVGDTFPVGCRFDDSIIYPGTFEHNPDSKDPIYSTEHGIYRPGCGMDNVMLSWGHDEYLYHICKEQSTLPDEALAMIRYHSFYPWHSAGGYRWMMDDDKDEKMLQAVKAFNPYDLYSKSDGIPDEKELKTYYMELINTYFPPREGETERVIRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1QK02</accession>
    <name>N1QK02_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pcc1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_146524</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CTAG/PCC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765651.1">
        <property type="nucleotide sequence ID" value="XM_016903706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QK02"/>
    <dbReference type="GeneID" id="27900843"/>
    <dbReference type="eggNOG" id="ENOG502SBSA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113770_3_1_1"/>
    <dbReference type="OMA" id="VQYRATT"/>
    <dbReference type="OrthoDB" id="10025739at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070525">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015419">
        <property type="entry name" value="CTAG/Pcc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31283">
        <property type="entry name" value="EKC/KEOPS COMPLEX SUBUNIT PCC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31283:SF5">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT LAGE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09341">
        <property type="entry name" value="Pcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF17530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="160" mass="17245" checksum="E45C835295C8289C" modified="2013-06-26" version="1">MTTTVEDPEFPCSLTVHIPFPSNRLAAAALRTLSVDQELSPLVKRHFSLVAPVSHIDSEPQKAPFEVSLWDTPPVQSAEAPSTIVRPAGGEPDDEKTVLKTEYKATTNRMLRVSVNGFFESLGTVVQTMEELDLDVVHAKGLESLEGAQGVEQGMTGSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1QK20</accession>
    <name>N1QK20_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glutaredoxin Grx1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_122921</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51220"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <dbReference type="ChEBI" id="CHEBI:34718"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:133977"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 glutathione + H2O2 = glutathione disulfide + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:16833"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="EC" id="1.11.1.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765697.1">
        <property type="nucleotide sequence ID" value="XM_016901807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QK20"/>
    <dbReference type="STRING" id="692275.N1QK20"/>
    <dbReference type="GeneID" id="27898944"/>
    <dbReference type="eggNOG" id="KOG1752">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026126_7_2_1"/>
    <dbReference type="OMA" id="IYTSPLC"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015038">
        <property type="term" value="F:glutathione disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03419">
        <property type="entry name" value="GRX_GRXh_1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000026">
        <property type="entry name" value="Glutaredoxin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011767">
        <property type="entry name" value="GLR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011899">
        <property type="entry name" value="Glutaredoxin_euk/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02180">
        <property type="entry name" value="GRX_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694:SF18">
        <property type="entry name" value="GLUTAREDOXIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00195">
        <property type="entry name" value="GLUTAREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="8">
        <location>
            <begin position="16"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF17576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="101" mass="10836" checksum="E976A47CF26F5E4D" modified="2013-06-26" version="1">MAAKAKAQEIIDSNAVAVFSKSYCPYCKATKSLLSEVGAKPYIIELDQVDDGAAIQDALEEMTNQRSVPNIFIAKKHIGGNSDLQGKKSQLPELLKAANAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1QK26</accession>
    <name>N1QK26_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_145835</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764748.1">
        <property type="nucleotide sequence ID" value="XM_016903294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QK26"/>
    <dbReference type="STRING" id="692275.N1QK26"/>
    <dbReference type="GeneID" id="27900431"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_12_1_1"/>
    <dbReference type="OMA" id="EPNGIHL"/>
    <dbReference type="OrthoDB" id="3786440at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF4">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_7G04540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF16627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="338" mass="35898" checksum="F1B378452BBA9220" modified="2013-06-26" version="1">MLRLFARSIRPLSKTTTTTTTTTSLPQVQRITPARLLSSTAMADNPELKASGLFDVSHVTALVTGGATGIGLMITQALVANGAKVYITSRREEVLNKAVETYNTGPGSLHALVGDVSTKQGIHQLVQKISQKEPQGIQLLVNNAGIARDDNTKFSSNDGPPDTSSAEAISEYFLRSEETQWQDTFQTNVTAQYFMSMAFLPALAKGGRITPGYSSSVVNVSSISGAMKGSSMGQFAYASSKAASTHLSRMLATTFQGFNVRVNVIAPGVFPSEMTGGDSNHVNKTEMDMKSSNPAGRKGHDTDMAATILFLAGKGGVFYNEQILYPDGGNTLSQPAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKZ9</accession>
    <name>N1QKZ9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TAFII55_N-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_146843</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016766062.1">
        <property type="nucleotide sequence ID" value="XM_016903904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QKZ9"/>
    <dbReference type="STRING" id="692275.N1QKZ9"/>
    <dbReference type="GeneID" id="27901041"/>
    <dbReference type="eggNOG" id="KOG4011">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016434_1_1_1"/>
    <dbReference type="OMA" id="KWEKMQN"/>
    <dbReference type="OrthoDB" id="153872at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08047">
        <property type="entry name" value="TAF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037817">
        <property type="entry name" value="TAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006751">
        <property type="entry name" value="TAFII55_prot_cons_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228:SF0">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID 55 KD SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04658">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01370">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAFII55 protein conserved region" evidence="7">
        <location>
            <begin position="173"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="334"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="398"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="358"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="398"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="454"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="486"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="524"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF17941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="588" mass="64608" checksum="E2E77B6AA429A05F" modified="2013-06-26" version="1">MLKLKIGAGTKGAQNNNNNASADGQRTPQTPAASAPTPGGGFKLKLSVSQPPTPSQPGPSSTFPQPTATTAEKKKRTYTKKNPDAIPKSKKRALEDDGAAPNPKRKISLKLGTASGAPASDASKTGPKLSLSKKQSRPQPKLLDIRARGKVPPRPKGVGYDSEDSDTEKDPAIQQALILRMEAGPDADYLRSAITEGRIGPHPSQGDAEVSFKFIERNYRRAMIKIQGRCYAAALVDLPCVVESMKSFDKKGWWKVADIAQMLLVLGRCETEEQAKMMPLPREVNKDTYQYAHGLTPPMHWVRKRRFRKRLNYNEVLNVEEEVNRLLQADKEWEERGGKVTSARAGDAQQHEQGMQDLPEEDDEADGDEQGADGNGYHFNLGDEDAEGELDDAVETVEHDEEMEEGDPDLEAGLQAMFDENEDEGAGDMSQLVSDSPAPIVDQAASMTGVEHALQPQQHPQLQQHHPSDMDATPVGTPAGEMTEEHSDDEGEEEEDDDEEDEEDESDDDDDDDADSPDVVDEDAAAKAAERAQQLEEVADLQREVEKARSKVASMTNQLLAQREKKKLLALEEELNMKKQVFGLDLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1QL06</accession>
    <name>N1QL06_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_130542</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016766001.1">
        <property type="nucleotide sequence ID" value="XM_016902362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QL06"/>
    <dbReference type="STRING" id="692275.N1QL06"/>
    <dbReference type="GeneID" id="27899499"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_11_1"/>
    <dbReference type="OMA" id="PLMCVAT"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF210">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ASQL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF17880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="512" mass="57993" checksum="D945BD1E6BAF5218" modified="2013-06-26" version="1">MAYDSSLLDDIHSVKATDVVRIQVYFIALYALYTIASALYVAFLGPLRKFPGPKLRALSRFPELLSLAQGNDASDQVALHAKYGPVVRVAPNKLSYAAGAQAHKDIYGHRKHGQPSIAKDPSFYVASPNGVHNLVSADDANHARQRKALSPAFADKTLKDLEPLLGHWMNKMKEKLQQKAEAGEKVDILKYFNCTTFDIMGDLAFSEDLHMLENGEYSAWVQAIFSSAKEMAKLRAFKMINWFTEWLVNTLLLNNPNAQLKRSQYWNDSKERADRRLASTPERPDLWTKIFEKSKVADGLTLDEYHSTASILMIAGTETTATALSGVMYYLLRHPQYLQALSQEIRSAHSTADDITMESLQHLKYLHAVLQEGLRIYPPLPSILPRIAPEGLVVCGQVVPQGTILGVSHLATYRSAEHFKNASEFRPERWLGEDVQYQDDHRDSFEPFAVGPRNCLGKSLAWHEMRLVLATAIFHFDFTLCEESFEWDEQKVYVFWEKKALWCKLTPVIRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1QLC1</accession>
    <name>N1QLC1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">UBZ3-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_149809</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760127.1">
        <property type="nucleotide sequence ID" value="XM_016905782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QLC1"/>
    <dbReference type="STRING" id="692275.N1QLC1"/>
    <dbReference type="GeneID" id="27902919"/>
    <dbReference type="eggNOG" id="KOG4696">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013053_3_0_1"/>
    <dbReference type="OMA" id="PFCPFSD"/>
    <dbReference type="OrthoDB" id="288987at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041298">
        <property type="entry name" value="UBZ3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012462">
        <property type="entry name" value="UFSP1/2_DUB_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07910">
        <property type="entry name" value="Peptidase_C78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18439">
        <property type="entry name" value="zf_UBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51907">
        <property type="entry name" value="ZF_UBZ3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UBZ3-type" evidence="9">
        <location>
            <begin position="57"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="94"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF12006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="495" mass="55047" checksum="5547670C38CB502E" modified="2013-06-26" version="1">MTHVRCPFCNSIQGDEYIIQLHIEEFHTEDSPFVPQRGEASTSAHGTHASLSSQSMPDDLWTKCTRRGCGEYIQLSAIDEHLDFHAAADLSEMDNGELAPPLPPRRSVSPSASPPPPLRTSIGRELSEQCKARLEKQRSKIKERGKESSSAHRSSISQAKDERRSTASSLLSYFSGTSTALTRSNLRALQAPQNPGRLGKRELGPHAYEKSMPSGVRKALIYGAEAQFTQRIGSDGKLYTHRSVPNETCGLPRAIADLCALEANTAATYLCHPSTKHIYKIECDGNFCGFWSSQVVLTYIQHVDREGPQSMPHVIEMQSIIEDAWKNGICAYDKVQTGGILNTRKWIGTTEALAFFTQIGVKVDALTFKDGEDEHEKSGVEALLDYIEAFYMSGMDTAEKVGTSHITQLPPIYFQRFGHSMTIIGIERLQDGSRNLLVFDSSFATSTPMLRLTEGRRARALVGDLLTPYRRSDQALSKWDEFEILIPQLQAVRLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>N1QLD9</accession>
    <name>N1QLD9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_32452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF18010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016766131.1">
        <property type="nucleotide sequence ID" value="XM_016908494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QLD9"/>
    <dbReference type="GeneID" id="27905631"/>
    <dbReference type="eggNOG" id="ENOG502SBZM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103049_0_0_1"/>
    <dbReference type="OrthoDB" id="5403157at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF18010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="235" mass="25279" checksum="1B057E15C6B92606" modified="2013-06-26" version="1">MPSPRTSPAMRPTSPLSPGAYKPSPAAGQYFDLLQPPQRPPHSRSNSNHQLSPHAQPQPHQPHQPHQPHQQQQQQHRHNRSLRLPSFSLPRFHPSRFPSATSSVQSTPDGNSHSSSPQPPMSPRAYQRMYNDAQKQLYFNQHQLFVVATATAAAATSAGRPTSPRLAPLGSPGPVTPLELERDEGYLVAGARNVTHSTTTSTATAAAAAVAVAATTPSDLADKMVQAEVARQTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1QM48</accession>
    <name>N1QM48_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EKC/KEOPS complex subunit BUD32</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Atypical Serine/threonine protein kinase BUD32</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">EKC/KEOPS complex subunit bud32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_146072</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765069.1">
        <property type="nucleotide sequence ID" value="XM_016903439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QM48"/>
    <dbReference type="STRING" id="692275.N1QM48"/>
    <dbReference type="GeneID" id="27900576"/>
    <dbReference type="eggNOG" id="KOG0198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_31_3_1"/>
    <dbReference type="OMA" id="FRENCRN"/>
    <dbReference type="OrthoDB" id="1668230at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF6">
        <property type="entry name" value="RECEPTOR-INTERACTING SERINE_THREONINE-PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="33"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF16948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="283" mass="31761" checksum="027E8E9700F9A787" modified="2013-06-26" version="1">MSEPPAENTGPLSEDSQPSLTTTDGVIRRTCRRAKGKLIDAGVSGIVELLANGDVVKSAWPGEDKDSEEDMAREAHVYHLLFKTFGAHKRFVKFLSYDETDYSITMEYMANGTLRSYLEAHHDRISTTQRHQWICELAEGMELLHSANIVHCDFSPRNMLLDETLGVKVADFGCVSINGSKSSAGGSVRFYPPRLQTRELIEPEDDLFALGSSIYEVVTGKPPYVDLETEQIQCLYRLDQFPDLAGLDFSDIIRDCWLLRAQSARHVHQRLLKVISPELGLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1QMJ7</accession>
    <name>N1QMJ7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">glycogenin glucosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.186</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SEPMUDRAFT_146566</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Self-glucosylating initiator of glycogen synthesis. It catalyzes the formation of a short alpha (1,4)-glucosyl chain covalently attached via a glucose 1-O-tyrosyl linkage to internal tyrosine residues and these chains act as primers for the elongation reaction catalyzed by glycogen synthase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = alpha-D-glucosyl-L-tyrosyl-[glycogenin] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23360"/>
            <dbReference type="Rhea" id="RHEA-COMP:14604"/>
            <dbReference type="Rhea" id="RHEA-COMP:14605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:140573"/>
            <dbReference type="EC" id="2.4.1.186"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[1,4-alpha-D-glucosyl](n)-L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = [1,4-alpha-D-glucosyl](n+1)-L-tyrosyl-[glycogenin] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:56560"/>
            <dbReference type="Rhea" id="RHEA-COMP:14606"/>
            <dbReference type="Rhea" id="RHEA-COMP:14607"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:140574"/>
            <dbReference type="EC" id="2.4.1.186"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the glycosyltransferase 8 family. Glycogenin subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.186" evidence="10"/>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765703.1">
        <property type="nucleotide sequence ID" value="XM_016903735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QMJ7"/>
    <dbReference type="STRING" id="692275.N1QMJ7"/>
    <dbReference type="GeneID" id="27900872"/>
    <dbReference type="eggNOG" id="KOG1950">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017171_2_0_1"/>
    <dbReference type="OMA" id="MVHFIGP"/>
    <dbReference type="OrthoDB" id="2014201at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008466">
        <property type="term" value="F:glycogenin glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02537">
        <property type="entry name" value="GT8_Glycogenin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000092">
        <property type="entry name" value="Glycogenin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0320">Glycogen biosynthesis</keyword>
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    </feature>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00057883"/>
        </source>
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    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
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        </source>
    </evidence>
    <sequence length="769" mass="85972" checksum="5C250700B4D86EE7" modified="2013-06-26" version="1">MAGQEDVYCTLVLNDEYLPGAAVLAHSLRDCGTTKKLACLILAESLQASTIEELQSLYNYVIPIERIGNPRPGNLYLMNRPDLLYTFTKIHLWRQVQFRKIVYIDADVVALRAPEELFDITETFAAAPDVGWPDAFNTGVMVLTPDMGEYYALRGLANAGDSFDGADQGLLNQYYEHRPWKRLSFKYNTTPSANYQYEPAYRYWKNGISMVHFIGKEKPWQRDREAHGAPGAFQEMLSRWWAVYDRHFQVSTRQYIGGQRHPITELVQDYKPAAQTYYATGYPVHPIDVQQQSHHPAEEHQPTRAATPPMTEPGEPSENLDQGNVQPTPTAEQRIFSAPYMEWDATRGAPPLETAPEAANFPVQVYQFSSDKTPFRPPQTYPEPPKDMYYQVPPPPKQEAEKKPKPIFPWEERQTKPTRKFIDDEPTTPHKPADSEAAYADELEVTSDSKLEPPTPTIKLNDTDPWTAFAQNRNAWDDVNGINDYVRALTSFQKNRGNVQVVQQKVSSTGHSASENLAEKKDPEDLVQQVEDARERRESLILTDFPSAIERPSLPVTPAPQRRSYWGDERDSTSDLPAAEGVPNQADWDPSAQLEQLRRSSLIGPGDLRLPDKKLTNRKMPPTAVSIPEHDPGYHTSMKSGVQEANVTGATENAHPTLQSKGGSSHCLDGNRDSSSSFTNTANSTTHSGTTTTSTLASTSQSSDNDESIVSTASSSAAMPGEFPLEQHGGSPLFSEPGFDKPPTVDEAQTKKDFQHEELLSPTQQQTTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="20"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
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    </evidence>
    <sequence length="738" mass="81293" checksum="F377CEDCE613E740" modified="2013-06-26" version="1">MSSASEEVYFDAMEAEVKIDRQSGEARAHGATKQVQKRQRQRQQQQEQQQQQQEQPPPPPPPQQQQQQQQHTATRHRHWNAAECSSAIPTVPKIPAQYLAAGLRVQEVGAGSPGAKPSTHSTSSKIITTPWSSSETTCRPTNYPVMEKAQSSSQPQQQHNHQHQQQQQQQQRRARRSNDESLEDDCSPDHPRDLPAAALSRSMSRASFSSSKRRSLPADVITRPSTSGNIHARPQSRLDGLRATAGLFFQQQQHPPFHPHHRDETTSRRSSVTRASYYVDASPLSPRQRALSPHTRSRRGSSFGTALSEPRQSFDTAYSEHRHHDEHVTLAAALEEPQESPTESSDQQGPDSSVDSHAADTVWDELDELKSRIRKLESSDKKPSTSSAAASGSSDRPRTATTAPTTINSSPKQSRKPDPADAPMDTPAPPAIEQHNEVGSAWSHIHPLLHDALARSRDSLSSNVFHNLEAVVADALQLAALTGSAAPSTAIGVANERQVRRRVDNLCRNMTDLCISLRDSKPETSPIVSSPATLPIEHPPADLPLRRFSRTSSLAVTASGAGRSLSRLEQRKASLLGPHTLGESPAASPRSPLPELSASDAESTPTHSNKLQPPRRLSAVPSRTTRSRVESKREGARGEDDRIDRPQSRAWTEYSSSLRATSRIPSQDRTNQDRSPGAPRRTSTSLRESLAARRKYETPPVLEEDGPLPKTRGFLSEPHCNKIPSRTSSIVRTRHLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1QN01</accession>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2 3">
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
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    <dbReference type="OMA" id="SDWGNRT"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF17807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="203" mass="22822" checksum="EE4A974FA1179D1F" modified="2013-06-26" version="1">MALKRKRSSPAFSSPASDASDASDATPQSCPPLSFFYHASKPVDVLLHKPTWSWPTYDDSPAHLNSRTRKRHRDNRPEEAQVRENTINRLFAAQRQHPHAEPVLSQAVTPVPSTHPQRSTLHSFWKLPKATVPMLMDEGNVQTEPSHARCEDCDRRIQVEDAMDLDDSIVGQESRCQTCLRQVCDMCAVLGVRRVCLQCASAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>N1QN20</accession>
    <name>N1QN20_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPI anchored protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_146497</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765599.1">
        <property type="nucleotide sequence ID" value="XM_016903691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QN20"/>
    <dbReference type="STRING" id="692275.N1QN20"/>
    <dbReference type="GeneID" id="27900828"/>
    <dbReference type="HOGENOM" id="CLU_1489887_0_0_1"/>
    <dbReference type="OMA" id="MAYIKIA"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004111012" description="GPI anchored protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF17478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="17269" checksum="D8C62BE6F7661581" modified="2013-06-26" version="1">MRYAVAAGALALFHLAAADATVTITEVSILIPSDCVASPTVAPVPFPSSGTATTTAQSTSVVESTATVTGSTSTSTSVASTAATTEVVPTAPGPVTSETPSPSAPSTEAGPAQTTLSTSSTAATGGTAATTTTTGPASSNEVSPTQATSTKAPPATQTGAADVKKPGVVGLAAIMAALVYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1QN58</accession>
    <name>N1QN58_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_113880</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paxB family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016766028.1">
        <property type="nucleotide sequence ID" value="XM_016901059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QN58"/>
    <dbReference type="GeneID" id="27898196"/>
    <dbReference type="eggNOG" id="ENOG502SNJ3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087059_2_0_1"/>
    <dbReference type="OMA" id="IGWICLY"/>
    <dbReference type="OrthoDB" id="5294024at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039020">
        <property type="entry name" value="PaxB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42038">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42038:SF4">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25129">
        <property type="entry name" value="Pyr4-TMTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF17907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="252" mass="29380" checksum="245645B2D3EA25AA" modified="2013-06-26" version="1">MPFELAYSYSNAHLIVQPADARLEPPESYLFIQDGLIISCGVLYALCYLFYMARTYKDKTLSGFVEYLCGTLSYEIYYAFTTTSTPFERLSFLIWFLLDLTFALVALFTAYPSSRRKLVGSRLFLGTLLGLTFLHFLCRKFPDEREQVTAYWTGLLLQLPIGWGSLIHLLKRDNGTKGHSLEIWVTRFLGCITAYLTFFWRYWNVPENWSYVGSFWSIACIALTMLPEVVYPFVYIRVHLDQDRRRGTKKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>N1QN62</accession>
    <name>N1QN62_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">beta-glucosidase</fullName>
            <ecNumber evidence="4 11">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SEPMUDRAFT_160784</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="4 11"/>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765664.1">
        <property type="nucleotide sequence ID" value="XM_016907907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QN62"/>
    <dbReference type="STRING" id="692275.N1QN62"/>
    <dbReference type="GeneID" id="27905044"/>
    <dbReference type="eggNOG" id="ENOG502QR4D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_2_0_1"/>
    <dbReference type="OMA" id="DMTMAGD"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000003">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF29">
        <property type="entry name" value="BETA-GLUCOSIDASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 11 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004111015" description="beta-glucosidase" evidence="12">
        <location>
            <begin position="19"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="13">
        <location>
            <begin position="790"/>
            <end position="858"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMF17543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="869" mass="93693" checksum="86B98EABB2F2D338" modified="2013-06-26" version="1">MMLPQVVLLAAAVPAVFAQLQPFANNTQENLDFAQSPPKYPSPWGEGLSDWKDAYEKAAAFVSQLSLLEKVNLTTGVGWEGEKCVGNTGSIPRLGFKSLCLQDSPLGVRFADFVSAFPSGQTIAATWSRDLYYRRGYAMASEHKGKGVDVQLGPAIGPLGRNAAGGRIWEGFSPDPSLSGIAVYETVKGIQDAGVIACTKHYIANEQEHFRQGGTPANLTASLSSNIDDVTMHELYLWPFAEAVRAGTGSIMCSYNQVNNSYACQNSYLNNYLLKGELGFQGFIVSDWGAQHAGVSSALAGLDMTMPGDVAFDSATSYWGPNLTIAILNGTVPQWRLDDAAIRIVAAWYYVDRPGNQVEDAPNFSSWTADTYGFKHAYAQQDYTHVNDHVDVRGEHAADIREFAAKATVLLKNKGALPLTGKEKLTAVFGSDAGENQYGPNGCADRGCDNGTLAMAWGSGTAEFPYLVTPLEAIKAEVRSCGGSIESVIDDYAYKQIDALSRRVSDVSGVCLVFANADAGEGYITVDGNEGDRNNLTLWHNGDDLIRNVTSYCNNTVVVLHTVGEVTVTPWYDHENVTAIIWAGLPGQESGNAITDVLYGKVNPGGKTPFSWARQPEDYGTEVLFDLNNGVNGPQDSFEEGIFIDYRALDKYNRTPIFEFGYGLSYTTFTFSNLNIQKHQVAAYSPTTGNSPAAPTYGSMSTNPDDYVRPANLSGVYAYIYPYINSTDLASSSGDPDFGVNYTWPAGSYDSAPQPYLPAGGAPGGNPQLWDVLFTVTATVTNTGSVAGDEVAQLYVSLGGPNDAKVQLRNFDRLSISPGQSATFTADITRKDLSNWDSGAQNWVISNYTKMVYVGNSSRKLPLSGVLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNP5</accession>
    <name>N1QNP5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome c oxidase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_138144</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome c oxidase subunit 6B family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765580.1">
        <property type="nucleotide sequence ID" value="XM_016902864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNP5"/>
    <dbReference type="STRING" id="692275.N1QNP5"/>
    <dbReference type="GeneID" id="27900001"/>
    <dbReference type="eggNOG" id="KOG3057">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133964_2_0_1"/>
    <dbReference type="OMA" id="NEWIAKW"/>
    <dbReference type="OrthoDB" id="1107506at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00926">
        <property type="entry name" value="Cyt_c_Oxidase_VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.140:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit 6B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.140">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048280">
        <property type="entry name" value="COX6B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036549">
        <property type="entry name" value="CX6/COA6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003213">
        <property type="entry name" value="Cyt_c_oxidase_su6B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46281:SF8">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 12, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46281">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02297">
        <property type="entry name" value="COX6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000278">
        <property type="entry name" value="Cyt_c_oxidase_6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47694">
        <property type="entry name" value="Cytochrome c oxidase subunit h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="31"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000278-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF17459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="86" mass="10378" checksum="D21B29073EEE687C" modified="2013-06-26" version="1">MSDDEDRVTMPFKFVTGFDARFPNQNQTKHCWQNYVDYHKCILAKGEDFKPCRQFYLAYRSLCPASWSQRWDDQRENGTFPTRLDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>N1QP16</accession>
    <name>N1QP16_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Cell division protease ftsH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">SEPMUDRAFT_146872</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016766105.1">
        <property type="nucleotide sequence ID" value="XM_016903925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QP16"/>
    <dbReference type="STRING" id="692275.N1QP16"/>
    <dbReference type="MEROPS" id="M41.003"/>
    <dbReference type="GeneID" id="27901062"/>
    <dbReference type="eggNOG" id="KOG0731">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_23_4_1"/>
    <dbReference type="OMA" id="ARQKGNF"/>
    <dbReference type="OrthoDB" id="1413014at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005745">
        <property type="term" value="C:m-AAA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097002">
        <property type="term" value="C:mitochondrial inner boundary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140567">
        <property type="term" value="F:membrane protein dislocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065003">
        <property type="term" value="P:protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000019">
        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.760:FF:000003">
        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1690.20:FF:000003">
        <property type="entry name" value="Mitochondrial inner membrane AAA protease Yta12, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1690.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050928">
        <property type="entry name" value="ATP-dep_Zn_Metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011546">
        <property type="entry name" value="Pept_M41_FtsH_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655:SF2">
        <property type="entry name" value="AFG3 LIKE MATRIX AAA PEPTIDASE SUBUNIT 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06480">
        <property type="entry name" value="FtsH_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="19" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="19" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 19" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="18">
        <location>
            <begin position="430"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="24"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="179"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="849"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="89"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="188"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="882"/>
            <end position="896"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EMF17984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="909" mass="99125" checksum="1854B8FE433AA247" modified="2013-06-26" version="1">MSGLLRRPQSIARSSRQLLEAASLSRTLAQRPASLPRPLYAYARSRQYSTEKENDDKQVDKKSGSQPKGMENLYSQQSPLSSDPQQPGKKPEEPDDGKSKLTAAEEKALEDTFALVKKGMPASMAADIDMALKKIKREGLPAELRETIAEVSKVGMSPARAAKLWRLTTHIARQTAEDVVNEKHAEPQQKTSDNPGPAGTSGNKDSGKKKEGQSPFGAVKEVKFDLSNFLVSAFVAYMLYRLFSPTENSREITWQEFRNTFFDKGLVEKLVVINGNQVRVYLHRENVAAMYPESPASQQGFYYFFSIGSVEAFERRVDEAQNELGIPSSERIPVSYTQEGSWANLILGFGPTLLFIGAITYMSRRAASGGGAGGGVFGMGKSRAKKFNHETDIKVKFSDVAGMDEAKTEIMEFVGFLKDPARFQKLGAKIPRGAILSGPPGTGKTLLAKATAGESGVPFFSVSGSEFVEMFVGVGPSRVRDLFANARKNTPCIIFIDEIDAIGKARAKSSFGGGNDERESTLNQILTEMDGFNTSEQVVVLAGTNRADVLDKALMRPGRFDRHIAIDRPTMEGRKQIFGVHLKSIVTNEDMEHLKGRLSALTPGFAGADIANCVNEAALVAARAAAESVTMEHFEKAIERVIGGLEKKSLVLTPEEKKTVAYHEAGHAICGWYFQWADPLLKVSIIPRGAGALGYAQYLPGGGNDAVLMNVKQLMDRMAMTLGGRVSEELHFDTVTSGASDDFNKVTRMATAMVTKWGMSNLGYIYYPSSGETQETQLQKPFSEQTAQNIDAEVKRIVNEAYKQCRQLLEEKKREVGLVAEELLKKEMIDRDDMVRLLGKRPWADPGEFSKYFSGSGDNKPLGPAPGTPPTGGIGDSDGGSVPPPLPGAGPAPPAPALYKQLEDASKRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1QP17</accession>
    <name>N1QP17_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_34141</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016766110.1">
        <property type="nucleotide sequence ID" value="XM_016908561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QP17"/>
    <dbReference type="STRING" id="692275.N1QP17"/>
    <dbReference type="GeneID" id="27905698"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_11_1"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF210">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ASQL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF17989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="512" mass="57878" checksum="97D5198E7A13767E" modified="2013-06-26" version="1">MALSTVISSISSSKLILLFPLILSGWAIFAFLQHLYNALYGPLSKIPGPRLRAFTILPHLKAMWTGNEAVAVVELHEKYGSVVRLAPDLVAVTGNAQTWKTIYESKANGVSAFAKDLIFYDAPLNEVHGPFGNDDPNSLRMRKAMAPAFSDSGLKRYETRFKTWCNALAARLDQHATDNVPSDMVKLFNCTTFDVMSDMLLSEPLHLLEKGDYVPFVRLIFTILRHVTRLKTIRLYSRPIARRLHLLLMSIPSIRQFAEKHHRFITDRVHERLTKSPEQPDIWSLVTAETSTAALISEEERYSIANELMIAGTETSATVLSGCLYHLLKNPAWMATLTRDIRDKYSPETPGGPDRITMAGLQANKLLDAVIKEAMRLYPPVPIGFARFVPPSGTTLNGYDIPGGNRVVIYHLATYRDSTLWTDPTGFHPERWLGDSKFQNDHLEAFEPFSTGPRGCSGKNFAWNEMRLILATTLLNFDLELRRESEGWLDQKVFLVWEKPALWVDVRKRGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M3ASJ0</accession>
    <name>M3ASJ0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cwf18-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_152110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756580.1">
        <property type="nucleotide sequence ID" value="XM_016907249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3ASJ0"/>
    <dbReference type="STRING" id="692275.M3ASJ0"/>
    <dbReference type="GeneID" id="27904386"/>
    <dbReference type="eggNOG" id="KOG3407">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091076_0_0_1"/>
    <dbReference type="OMA" id="MLVQGIH"/>
    <dbReference type="OrthoDB" id="10261348at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013169">
        <property type="entry name" value="mRNA_splic_Cwf18-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31551:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31551">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWF18"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="cwf18"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF08459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="208" mass="22850" checksum="1562389914BEABAA" modified="2013-05-01" version="1">MASTQALSAAASDRKARLAQLKSLKRKAPETADSQPDDGATAEAAQDDKEDVTARYISGRNYDHATKGAKLGFEAGPDQGQTTLELKAAELAAETKRHAEEEEKNDTPLDLFKLQPKKPNWDLKRDLDQKLAILSVRTDNAIARLVRERIQKQQEAAKGRVQSIGGGDVEAQGIEGTTLVEATNVREREDEEDARREREEDEALLDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M3AUY7</accession>
    <name>M3AUY7_SPHMS</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_150986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF09881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016906525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AUY7"/>
    <dbReference type="GeneID" id="27903662"/>
    <dbReference type="eggNOG" id="ENOG502S7FM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042952_1_0_1"/>
    <dbReference type="OrthoDB" id="5327145at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="390" mass="41967" checksum="8886114D04F02A4E" modified="2013-05-01" version="1">MFAARNLDENAINAQQQVAAAKPLNQSVRGLAPKTPANKPAFKTPARGNQNDENTKLDLGKTGGKDGKLDRNAFVTPANNRVRAPLGNKTTNAKALQTPALQLPPEDKVKGSSPRLRRSKIKVHEALDTAHDVLNTHPEERAIEYMPPREVPLNNDPDDILPLSMNLNALKGKNLTKGWWSEYSGKGENDEDSELSDFEEKVRKAEAEHKKRDTQKSKPVTKPFAGRAATAGPTKFAPTTVQARKAASVLSSRHTTKAAVPSFTAPTAMAKARLAGSIMPAGRKPAPALGNSRFPAAKAASNSTIGYSKGRSVSATTRPPLSNLSSRPQAKSKVEEPNRGTLDDLAGFGTMDLDDDEDGDLGFGVNRSGLDVLLDDDEEELFQLDPVEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>M3AVG0</accession>
    <name>M3AVG0_SPHMS</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_151104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016906598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AVG0"/>
    <dbReference type="GeneID" id="27903735"/>
    <dbReference type="HOGENOM" id="CLU_1489895_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF10041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="181" mass="19701" checksum="F2894352CA02D9E2" modified="2013-05-01" version="1">MFRRSDRMQLSASSDRPPLVTVNGELATKEPTRHGSLSGGLFTTRRAREATPQKTQRKTYRGHGSHRDLCSSPSTPPAKAAGTSAALLWQPPRDLTVNTTAGMPQQHTATNGPFSVNAELPVRWTDSRNTRPHLTAALGLSRAQCTKPPTLRVEGVAPLSEREGQSRTSGREAQRVQQQNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M3AY19</accession>
    <name>M3AY19_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PLC-like phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_45255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760508.1">
        <property type="nucleotide sequence ID" value="XM_016908960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AY19"/>
    <dbReference type="GeneID" id="27906097"/>
    <dbReference type="eggNOG" id="ENOG502QUGH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033662_0_0_1"/>
    <dbReference type="OMA" id="GIVMFDF"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF116">
        <property type="entry name" value="PLC-LIKE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004031191" evidence="1">
        <location>
            <begin position="18"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidylinositol-specific phospholipase C X" evidence="2">
        <location>
            <begin position="76"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF12387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="409" mass="44993" checksum="EB1323A77CE9149B" modified="2013-05-01" version="1">MLLIFATLATFSGPSLGFPASSSLVHKGASSGSLLASLALRKVLKDASPIFGDPSTLLGAENTSEPKTATWMKAYHDETKIVHMNLPGTHDAATWNYSHSTQDSLEYINGLANISAQDPANYKCQSKSLIQMLNAGIRVFDLRYAFDVTRTNLVFWHGNALQSETATVEDVLYAFYLWLDQHPSEALFLSFQHENGANDAQTQLALYQVLTSPSAQSYIVQARGQLDTLGHARGKITLLKRFDLDLLPDTYEDSIPGLHFSPLKWTDDGDNIELVYNSTSGSTAYIEDYYHPSTPSDSTAAENIQWKLNATEAHLNRAASNLHTDSLFWGFASSTKTNNEPPLTPQILALGNGTLTPQGGVNQQLVSVLQGMSGKRLGIMMFDFFEEPQGFLELFLSLLRPDEARNYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M3AYL2</accession>
    <name>M3AYL2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_149260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760763.1">
        <property type="nucleotide sequence ID" value="XM_016905445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AYL2"/>
    <dbReference type="GeneID" id="27902582"/>
    <dbReference type="HOGENOM" id="CLU_2672690_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF12642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="75" mass="8201" checksum="B33DC662D43C57C9" modified="2013-05-01" version="1">MEHDFIFDRWLEQKGSFQHRPQPSVPTICNTKSQAAPQQQAPTWATVATVAAGVAATALTVHGLYRARGMRGVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M3AZ01</accession>
    <name>M3AZ01_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">4-coumarate-CoA ligase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_86056</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760893.1">
        <property type="nucleotide sequence ID" value="XM_016910402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AZ01"/>
    <dbReference type="STRING" id="692275.M3AZ01"/>
    <dbReference type="GeneID" id="27907539"/>
    <dbReference type="eggNOG" id="KOG1176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_2_1"/>
    <dbReference type="OMA" id="RVAAYKY"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF422">
        <property type="entry name" value="BCDNA.GH02901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="49"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="3">
        <location>
            <begin position="454"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="490"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF12772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="577" mass="64021" checksum="1855E1C4F6EDC5B7" modified="2013-05-01" version="1">MPVFPSLQQDILLPRDITIWEWLFESPTYSPLLRFPPEQQCGFTDAITKERLSWQDVKDAATDLSTALVKRYGLQEGETVSLFSANTIWYPVAMHATLRVGGRVSGASPGYNEEEMTYALQKANAKFLMTHKDSMEVAIKSAKTAGVPMENIILLEGELDGFKNIKTLIQEGRELGNPVPYSRIPAGKTNFDVCGFLSFSSGTTGLPKSVMIAHQNVIAQCLQVMAITPSDHKRVLAVLPSFHITGLVHVLHLPLLINAEVYFLPAFTMKAMLDTVTEYQIPELLLVPPILIRMVRDPIVKKYDLSCIQRFSSGAAPLSEEILVLLKKQFPHAGFKQGYGMTESCSCITAHPPQYYDFQYAHTVGTICASTTVKILKEDGTECDINEPGEICAKGPQIVMGYLNNEQATKETFDDQGYLHTGDQGQIDAHGLLTIVDRIKELIKVKGIGVAPAELEDLLLGHAGVEDVAVLGIPDDYAGEVPKAYIVPRSNSNNHNNSNNNTQNPSSLQELGRELLQYVRENKVRYKAIKEIEFVEIIPKSASGKILRRVLRDLEKKKKKEGIRGSVVVREERARLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M3B0S4</accession>
    <name>M3B0S4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CsbD-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_116417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761493.1">
        <property type="nucleotide sequence ID" value="XM_016901253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B0S4"/>
    <dbReference type="GeneID" id="27898390"/>
    <dbReference type="eggNOG" id="ENOG502STPC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_167691_1_0_1"/>
    <dbReference type="OMA" id="DAGQWKK"/>
    <dbReference type="OrthoDB" id="2565331at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40636">
        <property type="entry name" value="CSBD-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40636:SF1">
        <property type="entry name" value="CSBD-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF13372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="90" mass="8415" checksum="ED8BAE830C1D0FD0" modified="2013-05-01" version="1">MPIGQSSTNNTTSGAEGAAKGLTSTLGNLTGGVVKTAGGAVGSVGQGLGETINNTTGTKAVGNGLQGLTGGVKDGADALGKGAENAGQWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M3B808</accession>
    <name>M3B808_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prokaryotic-type class I peptide chain release factors domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SEPMUDRAFT_81256</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764088.1">
        <property type="nucleotide sequence ID" value="XM_016910269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B808"/>
    <dbReference type="STRING" id="692275.M3B808"/>
    <dbReference type="GeneID" id="27907406"/>
    <dbReference type="eggNOG" id="KOG2726">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089470_1_1_1"/>
    <dbReference type="OrthoDB" id="277888at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000065">
        <property type="entry name" value="Peptidyl-tRNA hydrolase domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052405">
        <property type="entry name" value="Mito_Transl_Release_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46203:SF1">
        <property type="entry name" value="MITOCHONDRIAL TRANSLATION RELEASE FACTOR IN RESCUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46203">
        <property type="entry name" value="PROBABLE PEPTIDE CHAIN RELEASE FACTOR C12ORF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="6">
        <location>
            <begin position="41"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="124"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="124"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EMF15967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="198" mass="21503" checksum="9D25971993F554B9" modified="2013-05-01" version="1">MFLARLRNSNFAVTSSSLIGRSARTFSIQSAQLEKPLPPRIVISEKDIIESFLKGSGPGGQKINKTSSAVQLKHIPTGIVVKNQATRSRDQNRKNARRILGEKLEELEQTPRWAATEVKSEKIRRKKASAAKKSRRKYRQLDEGIVLPEAEAEAAEEEKKHDAVNAGAGAGAVNKEGTSVEVEGTNSQDTRVGSDGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>M3BP91</accession>
    <name>M3BP91_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fungal_trans-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_54968</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF07978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756099.1">
        <property type="nucleotide sequence ID" value="XM_016909325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BP91"/>
    <dbReference type="STRING" id="692275.M3BP91"/>
    <dbReference type="GeneID" id="27906462"/>
    <dbReference type="eggNOG" id="ENOG502SJFF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006632_3_0_1"/>
    <dbReference type="OMA" id="HIQADDW"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001080">
        <property type="term" value="P:nitrogen catabolite activation of transcription from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF4">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN DAL81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="57"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="92"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="608"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="625"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF07978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="810" mass="90272" checksum="F22B0AEE7605B05F" modified="2013-05-01" version="1">MPSFHHQQQSQQQSSASASASTSTSQASPPPGPPQQQQQSVDGADRARAYKSRNKRPCDFCRYKKAACHLESAPPCELCIRYNKECTFVESPAKRRRPNDSAADKENHVHGNGIGNGHSHGHGHSHGNGSMFKSARTGSHDHTPAFTNGNILDLQQDLLPWENGINPFSVNGIPALDGDLHNPDFPFDPALYQEPVPFETFEPLSASTMHSIDHKFPNNHRHSSSFDHSTSPQSSIASLPIDLTLPFDSTSGEPSLDRQHSSNAQIVGLGGELDPYLLSRYRYDEYNEASFQSVRMRKMNSGPAESQQSVPAFFVIQHNGLASKAQPRDKSDSGEKWRRELEELVPEEVGKRLIRLFYRYVQPYFPILSREGGERDADGFRVPREMPPCVLAAIYGHALPFCPWDEKLCVDVYTPSSADALFKLSWLSCQPLLHTPTIAVLQTLLMLVQRRPTNRHVSDTPFKWVMMSTAVSIAQALGLNRDPTDWPIPSWEIQQRKRLAWAVFVQEKWLALNFGRSSHIQADDWDVPKLTEGDFPEPDRSYDENHIADFSCQHFIKLCDLTMIVDDILRKLFSIKATRQLHTSLEATLEVAKPLRIRLTEWNQTLPAGLLPSQPATTTTTTTTNGAPSPILNSPGSDRRKSVQLELDGNGSLQLAYITAKIELFRAMLRPRVTDANAAAITALRTGALAVAKEISTFLDDLHARELEAFWTSYARTNFTIASSFMLLLFATSPTLPDAKECLSLLNAWRSLLRIKSRSCDLLSLALLRLDGVFVAGMDQLIELSPAAEQAWREKKENGGFGNQKEGGMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>M3BRL7</accession>
    <name>M3BRL7_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="10">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_166431</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="10"/>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756884.1">
        <property type="nucleotide sequence ID" value="XM_016908233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BRL7"/>
    <dbReference type="STRING" id="692275.M3BRL7"/>
    <dbReference type="GeneID" id="27905370"/>
    <dbReference type="eggNOG" id="KOG1867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008279_11_2_1"/>
    <dbReference type="OMA" id="NVSCNCI"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF33">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="12">
        <location>
            <begin position="178"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="440"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="488"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF08763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="566" mass="62454" checksum="F8B5636A6EDA95BB" modified="2013-05-01" version="1">MSTTTSQTPSATPESASTSAPKLLKKASTTDIKSGAPLQTVFGCAHTKQLLTSARPAAINGYQKAITSLQKEDNVSWAVHKGPSGTGVTGGVTYLCLQCPYVSLTREPHRKDHTFAIESANGFIFCHVCKDFVYDISFEAIRAPPNKKRKLSALADENDKKLVAANSTSISCAATGLRGLYNMGQTCFMSVILQSLIHNPFIRTYYLTEGHRSSDCEREACTSCALDDIITDFYGTEKHEGYGAVHMLQGCWKNGGNLAGYSQQDAHEFLGFILNSLHEANTEEEEKKDAKDCECVVHQTFAGMMRSTVTCSTCKTVNSTSEAFMDLSLDIKSAGVVVKKKKLALTGATQTVKEQLPVDLTECLDRYTTAETLSSDNYTCRKCDGPKEAKKKLTLTRLPPVIPIHFKRFSHSKGSKESQKVDTRVRFPFKLDLSSYVTAPAKSSTEPAKKAGNGVSKGAEAAKDHKGEDDDEDGDKMPVKKRQTKSTEEEEKEEDEEEEDISPDQPIYELSSVIVHKGKIDSGHYICYCKQVEHWFRFDDSMVVQVDDKEVLNAEAYMLFYVVAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M3BRR6</accession>
    <name>M3BRR6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Exportin-5 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_151736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756929.1">
        <property type="nucleotide sequence ID" value="XM_016907009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BRR6"/>
    <dbReference type="STRING" id="692275.M3BRR6"/>
    <dbReference type="GeneID" id="27904146"/>
    <dbReference type="eggNOG" id="KOG2020">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003712_0_0_1"/>
    <dbReference type="OMA" id="IAKRSWG"/>
    <dbReference type="OrthoDB" id="2215036at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042565">
        <property type="term" value="C:RNA nuclear export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045478">
        <property type="entry name" value="Exportin-5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045065">
        <property type="entry name" value="XPO1/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223">
        <property type="entry name" value="EXPORTIN 1/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223:SF3">
        <property type="entry name" value="EXPORTIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19273">
        <property type="entry name" value="Exportin-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exportin-5 C-terminal" evidence="1">
        <location>
            <begin position="350"/>
            <end position="1213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF08808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1261" mass="142193" checksum="FCB1F27F34C3DE71" modified="2013-05-01" version="1">MATSGFGTYWQRPDTAAHLEHITNALEATLDPRVSNTVRQQALQHLEAVKSQHDAPYHGFTLAYDWNQNNAVRYYGLQLVEFAVRYRWNEYSDGQAAQLRTWIQRLAGNLRESDAVYLRNKVGQLWVEVAKRSWGGGEWMDMDTLLIDLWKMDTGVVNKVLVLGILEGLNDDIINSDDAVAGLRLDVLGDGLVEILVPQVFYSTLQKDKIRNVRAEGEGWLARITEFFALCVKEARLRQDEPEVTEKMEMCAIKALNALRSIMGWISFKAVDEVNCVDCLYLPFYTTNVVLQTAAVQVLYALLGRPQHGANTNEVWSSLIRQAMQPDKITMIRNAFEVTMTVPGEDDEKYTLQKKMAALLSVMADGIALNPALAEQSLDLPALFELLALVTRHKSLTVSIPVLHSWTKLLNVHEDKIIDLVLTALPILLEVCSDRLIRYEALPEETDDETMRWLDEDFDTVPERHAFLGNYRRYGATIIEGIARMRPIDALSIVLNQMREMVETGPYTTARGFDSSTYTKSAYPVLRFDASYCTVAAALKGYASWTRDVSEISTDHELFAKVQQDQRQALESLQQWCHGMTSIHTDDPGVADELLQTMVAVLRVLESPPQSFILAMVQHLLTMQLEDQPQHSQFSDAIKSFEALRVVELQKLALTYPNVLLEVYNELELRIETLAQQYGDDQRLVWGYRSFLFMIVHRATGIDEQVRLARLQQMLQSTYEAWTGEALQASCSDFEAFCATVGLTNIADFYQEHEFARTPDWSARTLNEAGQARQNEIKEKGDRLPLRMTKSLLSAATERLRAGTPEYDTACQLWGPLIPSILHPLLQMTRHAQAFHNMSNWRHLPAELQMVVKRTLQDRFWQSGISSESKEEFYARISGSKTSYEGFASTVRGTMRNVREMGYHIIYLMTKFEEQFYGIDNLAHPLSSALFDDAGSLSANHLHPLINLTTGLVQRCPTRHRGDFLPPILRKLFVCLDGKISADWEAISQAEQQNKKENDELGDEMRTESVLRQLTYSMVTFVPWLLEFDSQRQAHAGNNRHAPMNGHDPEMKTAALSDLILTDPSVLEPMILFCTHALRLHDGRCCTTICKVFRTLIPLFSHTAPNGSVVSPDSAASVREFISTEVLKACITSLNDPYFADVQKELATLIANIIVMYGPQTATPRHVLLSLPDITEPKLEKAMAKMLRTHNERSQRSAVLELLEGVRGVSIHEMGKVEQAKAKKKENKGVASQYTMAAENTGVVRGGEEGLEGVAGLFGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M3BTV6</accession>
    <name>M3BTV6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_151135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758206.1">
        <property type="nucleotide sequence ID" value="XM_016906621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BTV6"/>
    <dbReference type="GeneID" id="27903758"/>
    <dbReference type="HOGENOM" id="CLU_2298496_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF10085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="101" mass="11798" checksum="C8EC38B0F8CFC599" modified="2013-05-01" version="1" fragment="single">MLLCSLVVGDQPLEHFDVRPYIRPRCTLQSAPLEERRGGECADGGIEERFLSMVRCSSTPWFRSRCSGNNRRLEWERGTEDSQRKSRKQRKQKTGEVVIYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>M3BUK9</accession>
    <name>M3BUK9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_118328</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759140.1">
        <property type="nucleotide sequence ID" value="XM_016901420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BUK9"/>
    <dbReference type="GeneID" id="27898557"/>
    <dbReference type="HOGENOM" id="CLU_1887058_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF11019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="135" mass="14792" checksum="91F77B45341C8917" modified="2013-05-01" version="1">MPIAGGLKHHRALPPQAYFIPAVGQPCLCEKPLYWIDLAKGCILYSTADGHHSLSTPSLLEHSYRMGNMDSMGRTPLPPLQLYLLSAPEYNPEHNQRHAPIHADACPTTRTTGAMAWLSLFRPMGASPTHLDVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M3BVQ9</accession>
    <name>M3BVQ9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_150347</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
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            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46539:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ATL42"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004031571" description="RING-type domain-containing protein" evidence="11">
        <location>
            <begin position="21"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="202"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="358"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="268"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="410"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="454"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="268"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="297"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
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            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
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            <end position="525"/>
        </location>
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        <location>
            <begin position="526"/>
            <end position="536"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EMF11409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="542" mass="57605" checksum="532744C4225B8072" modified="2013-05-01" version="1">MDFMIWQAFVLLFLAWTATAQLILSPSNTTTTDPAYHSGAVQVAIWHQPTASPVAAFLVTALTQAAADNIPSAGLSGHTFVVNANNQLTVESTDVALIDCDPSSGNIGPEYIFNTATTRRALAIILYSTTAQTCHGSGFGTYANVYTMKSLENSQSLMAAVDTDTAYASLMSRDAVSGNGTSPGGTTNGQNPSPLGPSPSTAVAMIILYSITGVITALFLCIIITGAVRAHRHPERYGPRNLAGRPRQTRARGLARAMLDSLPIVKVGDRTDHPAKPTEVELESGQHGQVESVGDRTTTPTAPATAAATTASPDGETPRNGTSTEDAALKTTGSGIAAAAAATGRSSTNAEEESKQGCSICTEDFNVGEDQRVLPCDHRFHPECIDPWLLNVSGTCPLCRIDLRPADNPEDAAEVDEHGNPIASSDRLAPPLDHAEGSRAARVRRSIMVGILGSPRPERMSREERVSALRRYRESTSARGAEQAQGSSSDIGEPEEETSRRRRLRDLFRIRTRRTGEPETVREEPASQVAASSVPSTEARTS</sequence>
</entry>
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        <recommendedName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_149089</name>
    </gene>
    <organism evidence="3 4">
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        <lineage>
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            <taxon>Dothideomycetidae</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="entry name" value="Mtf2/C5D6.12-like"/>
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    <dbReference type="PANTHER" id="PTHR39468">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39468:SF1">
        <property type="entry name" value="MTF2-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <proteinExistence type="predicted"/>
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            <end position="367"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="444" mass="50649" checksum="02791AE6C843482D" modified="2013-05-01" version="1">MLTKRASSRSLGIASPSHATFLPFLYQTRSILRAYSDEFPSAHPADHLNLEHKAGQGAAEEQRLQDIRHKWSSKSVGRGRGRSARSKDEPTSQRMQNAMRRPKQLHSIPFEGDTGSTTPAERLRNTTMTPREMQVFEELFRKGIASKKDGKMKTGTQKQQQQETVQFPELLRPLAEEAEELRRRVAREDNKTSSVRPVSEFEIKDAQALAIKSLMDNATSDVQLWTILRDQVFDRLRSTPDSIALKSNFTALPALLQHYMHLQTSKLPTTHSLGLVVLPELKKLGPLAFALGATTELYNQHMHLLWRQYRDMEAISLVLEEMDREVYSFDHGTLDLLDRILDYASDAADGKLGRAVQALWGMDRKKRGVVKMRDWRRTVNEKLRANALEEAKKAEIGFEDEDDMEEEAGDEERATLDEDVAMKRGHEERRSRMRRMSAGQIALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2022-12-14" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>M3C0C5</accession>
    <name>M3C0C5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_107744</name>
    </gene>
    <organism evidence="1 2">
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        <name type="synonym">Septoria musiva</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016900698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C0C5"/>
    <dbReference type="GeneID" id="27897835"/>
    <dbReference type="HOGENOM" id="CLU_1023661_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF13781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="272" mass="29925" checksum="C9A67E93BD382106" modified="2013-05-01" version="1">MSRGHFGLTRLSSGQVTKVRSSKLHVLGATYIPGVNYCMRKEKAIEPIGYSYPGFGCADNDDDCCAAVPLAGPIDLPGPTLPTVSTRYLTVLHMRQSPRKLQQCNSIIIINILIYRATVRYTQECVIERERLSGGPRIDFDSYALLRIPIALLDINPICPIASYTATTYYYLVVAIAEDFVPATPIPTSSGTTTTTTPTAIRPRDVIANPIPIPNIVLSIVLIYILIEDIYRRSAKITVRTLSSISPLRLPSRSRRVTTSVLSLTIVFTVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M3C0D2</accession>
    <name>M3C0D2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PHP domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_26434</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic/archaeal RNase P protein component 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761907.1">
        <property type="nucleotide sequence ID" value="XM_016908410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C0D2"/>
    <dbReference type="STRING" id="692275.M3C0D2"/>
    <dbReference type="GeneID" id="27905547"/>
    <dbReference type="eggNOG" id="KOG2363">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048451_1_0_1"/>
    <dbReference type="OMA" id="CYGPGIT"/>
    <dbReference type="OrthoDB" id="17948at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002738">
        <property type="entry name" value="RNase_P_p30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13031:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13031">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01876">
        <property type="entry name" value="RNase_P_p30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="PHP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="284"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="284"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="318"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF13786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="354" mass="37702" checksum="150AB05459620C4D" modified="2013-05-01" version="1" fragment="single">FYDLNIPWKPSDPDLPQTLAFLHELGYNTIALNHTISGKIPTDLTNPIPTQESLQSTHRATLDPIFKNNNCTILRRITLVLTEISHQNAKLASLASAYDLLALKVTDEKSLTQACGNLECDIITFDLTQRFPFYFFKHQKMLQVAIGAGKRLEICYSTGLMGDAKCRVNLISNATQLIRATKGRGLLMSSGGEGGGGGGGGGGGRMVASAAAGLRGPWDVINLAAVWGLGQEKGFEAMSKEPRGIVVRGKLKRTGYRGAVDVIYGGEKPAVAFGKDAKEAAGAAAGKGKQKWKQGGQQKKDENQQQGQKRKAEGEVPSSESGEQPMSKRQQKKLAHAARVANGTAGPAATSSGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M3C197</accession>
    <name>M3C197_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Quinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_162284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762192.1">
        <property type="nucleotide sequence ID" value="XM_016907992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C197"/>
    <dbReference type="STRING" id="692275.M3C197"/>
    <dbReference type="GeneID" id="27905129"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_1_1"/>
    <dbReference type="OMA" id="CDIRGVF"/>
    <dbReference type="OrthoDB" id="10257049at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08241">
        <property type="entry name" value="QOR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051397">
        <property type="entry name" value="Zn-ADH-like_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677:SF4">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="12"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF14071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="336" mass="36719" checksum="DBF937DB83D12B2F" modified="2013-05-01" version="1">MKAIQIQEYVPGPLSLRVTSIPDPIPTADQYLIAIKACATNFFDLLQIRGKYQHQPPLPWTSGAEFSGIILSCPSSSSSPKFRPGDPVFGSSQGSYAQLICCTESQIQPLPSGWNFLDAAGLFVTMPTSYAALITRANLQAGEWVLVHAAAGGVGLAAVQIAKARGATVIATAGTKEKLEIAKRFGADFGVCYRENEDWTKEVLKLRPRGVDVVFDPVGLISPSQKCIAWNGRLLVVGFAGGPIEKIATNRILLKNISVVGIHWGAYAKFEPQRIEEVWRELLKLMENKEKIRPTNFTDKVYRGLEDVPKALEALGGRETWGKVVVDLPEGRESRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>M3C367</accession>
    <name>M3C367_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_148357</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762847.1">
        <property type="nucleotide sequence ID" value="XM_016904870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C367"/>
    <dbReference type="GeneID" id="27902007"/>
    <dbReference type="HOGENOM" id="CLU_2795588_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF14726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="68" mass="7304" checksum="708D5D2BCFF06DC1" modified="2013-05-01" version="1">MLIQQAVWRTSRRLMIVGRCKSGCGWLSLDARTVTRGMTGTKIGGLNTLLDCGRISSSLVVNAHTASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M3C3E1</accession>
    <name>M3C3E1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_116055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762917.1">
        <property type="nucleotide sequence ID" value="XM_016901222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C3E1"/>
    <dbReference type="GeneID" id="27898359"/>
    <dbReference type="HOGENOM" id="CLU_2401064_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF14796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="93" mass="10270" checksum="D00736410596E577" modified="2013-05-01" version="1">MAFGNGKNVSTWIRICQLSLLTAVTSRKPSERCTANCIPFAQWGHLRERHGRSHRVPGHMTMIAQAISRLLWPSCYVSALPGTDIVLILGVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M3C6G9</accession>
    <name>M3C6G9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">D-malate dehydrogenase (decarboxylating)</fullName>
            <ecNumber evidence="4">1.1.1.83</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_147617</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(R)-malate + NAD(+) = pyruvate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:18365"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15588"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.83"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.83" evidence="4"/>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763967.1">
        <property type="nucleotide sequence ID" value="XM_016904418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C6G9"/>
    <dbReference type="STRING" id="692275.M3C6G9"/>
    <dbReference type="GeneID" id="27901555"/>
    <dbReference type="eggNOG" id="KOG0785">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031953_0_1_1"/>
    <dbReference type="OMA" id="VGMIWAG"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046553">
        <property type="term" value="F:D-malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050501">
        <property type="entry name" value="ICDH/IPMDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011829">
        <property type="entry name" value="TTC_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02089">
        <property type="entry name" value="TTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43275">
        <property type="entry name" value="D-MALATE DEHYDROGENASE [DECARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43275:SF1">
        <property type="entry name" value="D-MALATE DEHYDROGENASE [DECARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="11">
        <location>
            <begin position="6"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF15846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="367" mass="40354" checksum="9F64EDE3FA2B99C4" modified="2013-05-01" version="1">MAKTYNIACIPGDGIGVDITEAAVEVLNKLATTVGSFSFNFTTFDWSSKAYLERGWYMPEDGMQQLAKHDAIYFGAVGWPSVPDHISLWNLILPIRKWNNQYVNVRPTRILPGTTAPLAQLQKKPSDLDWIIVRENSEGEYAGQGGTTHDNSPHTVATEVAIFTRVGIERIVRFAFETAKSRPRKKLTMVTKSNAQRHGMVLWDKVFYEVAKDYEGVVEHDKMLVDAMTVRMVNKPESMDVIVATNLHADILSDLAAALAGSIGIAPSSNLDPTRQYPSMFEPIHGSAPDIAGQGIANPVGAFWSAAEMVRWIGQGALDDVADKLMRAVENVTANAETRTRDMGGKATTKEVTEAVVKQIEVVFGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M3C7Y4</accession>
    <name>M3C7Y4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_152314</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF08000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756121.1">
        <property type="nucleotide sequence ID" value="XM_016907370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C7Y4"/>
    <dbReference type="STRING" id="692275.M3C7Y4"/>
    <dbReference type="GeneID" id="27904507"/>
    <dbReference type="eggNOG" id="KOG3991">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014832_6_1_1"/>
    <dbReference type="OMA" id="WMKLNPH"/>
    <dbReference type="OrthoDB" id="18915at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22749">
        <property type="entry name" value="Otubain_C65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.60">
        <property type="entry name" value="Peptidase C65 Otubain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.20">
        <property type="entry name" value="Peptidase C65 Otubain, subdomain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019400">
        <property type="entry name" value="Peptidase_C65_otubain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042468">
        <property type="entry name" value="Peptidase_C65_otubain_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042467">
        <property type="entry name" value="Peptidase_C65_otubain_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12931:SF15">
        <property type="entry name" value="UBIQUITIN THIOESTERASE OTUBAIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12931">
        <property type="entry name" value="UBIQUITIN THIOLESTERASE PROTEIN OTUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10275">
        <property type="entry name" value="Peptidase_C65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="OTU" evidence="8">
        <location>
            <begin position="189"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="573"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF08000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="604" mass="67113" checksum="4F9DC35084D5E3B0" modified="2013-05-01" version="1">MMDRQGSVATAPYYHNHHLHHHHHHHQQQQQQHAHHLQHYQEQATALAYCPTVPLSVQQQQQQQQQHQHSHHAQQQASGLAGQQTQLSLVPAGAIYPHFGHHHHSSTLPHRTRHPLRAEALQHTMASEPSHAMSDEELAAFQQASESYEAPITGPLVGQRQPSTALTSEYASADPVYQAKTQALPQKYSHYRTVRGDGKCGWRAVAFGYYEALIHHGDLNRFGMEEARLKSIAPLLIQAGFEPMMMEDFADAAYDLLREIANAAAEGLDALSLLLERFNDEMLQDYIITYLRSLTAAWMKTRETEWAPWLSNQSVDAYCRDEIMPVGAEMDNVALQALKDVLLSPAGIRLEVLYLDRSEGSEVTMHRFDPVAAGGFTLGSVRLLYRPGHYDILYKQEDLPAPTPAPAVVPTYLQYSSQPFYEPASDLNFSAMPDFMTLLPGMSYANQAPFCGGVPSSYDSYESASEFGFDTNSKAPVLSCTPTPSAPAPQSHVQSQPMCASASTPVQMVAPPSQLTHDIDVRTVPQLGHAEFGAGPFRPSRHTFDSAFMSGSQHFQTSIFRNSHYNNAHFNNPHFQPEQWNPDCEYATASSSSGGKSSRHKNSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M3C9Y2</accession>
    <name>M3C9Y2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_29459</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756786.1">
        <property type="nucleotide sequence ID" value="XM_016908454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3C9Y2"/>
    <dbReference type="GeneID" id="27905591"/>
    <dbReference type="HOGENOM" id="CLU_2628747_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF08665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="63" mass="7248" checksum="CB177E6DF9893B59" modified="2013-05-01" version="1" fragment="single">GIILDKAIVDITIYKFTSGLRYIAVLRVKTVKTLIFKKLFDFSLFTTSLRSIGIVRKADINRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M3CDA3</accession>
    <name>M3CDA3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="15">SNF2_N-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SEPMUDRAFT_150065</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759157.1">
        <property type="nucleotide sequence ID" value="XM_016905945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CDA3"/>
    <dbReference type="STRING" id="692275.M3CDA3"/>
    <dbReference type="GeneID" id="27903082"/>
    <dbReference type="eggNOG" id="KOG0387">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_7_0_1"/>
    <dbReference type="OMA" id="PTWTGQF"/>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22254">
        <property type="entry name" value="CSB_WHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18000">
        <property type="entry name" value="DEXHc_ERCC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000039">
        <property type="entry name" value="DNA repair protein Rhp26/Rad26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058951">
        <property type="entry name" value="WHD_Rad26_CSB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25875">
        <property type="entry name" value="WHD_Rad26_CSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="475"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="805"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="203"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="385"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="992"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1060"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1114"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="78"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="211"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="267"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="282"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="327"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="348"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1006"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1024"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1141"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1165"/>
            <end position="1177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMF11036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1270" mass="142481" checksum="8934DED458DCA03A" modified="2013-05-01" version="1">MSSPSQPRTVIDPLSDGDTSEMQATDIVSQPEDIDAGNDTNKGEPDLEDDEAARLAALGAGVRDQADLERDIGQQADQALAEQTLEREQKRLDKTQKEKTRMQVALKLAEKNLAKPAGSATKNKYRAEIEHYKALIANLDNDLAQIQNRIREQLNEEQDGETLLEDTNNKRMPGESQREFLIRTGKITPFSKLGQRLLRTSSSLGEVLLNAEEEGQIEEEEEEAEAEILEQSQSGPKSHRNLLAPGFEQDDNSAAASTAEDTEDDAALARRLQDEEDARERPAKRRRLQSRRQMRGPSPDVASTADDSDAFVPDVNEDGLAAVGQSADEEEPQDEAAEGDFPLDTPGVKRKGKGKRKAVRVVDGQEDFAGVDDGNEEVYQARLQSWTQRRSAARRRHKKPTGDGSEENDTTVDADVVKAEGEVTSPLDEIEETRPEWEMPHPTRPDAEFDGGFRVPGDVYPSLFDYQKTGVQWLWELYSQQVGGIVGDEMGLGKTCQVISFLAGLHYSGKITKPIIVLCPATLLKQWVDEFHRWWPPLRVTILHSSGSGMLDVKREARFEDDLDDDRRKKSRGRPNPSVRNVIDRVVQDGHVLVTTYAGLVNYADQLLPVNWEYCVLDEGHKIRNPNAEITIFCKEIMTHNRVILSGTPMQNNLEELWTLFDFVFPMRLGTLVNFKNQFAIPIKQGGYANASNLQVETAMKCAETLKDAISPYLLQRFKADVATDLPKKIERVLFCKLTKLQRDAYQWFLDSEDMKSIMNGKRQALYGIDILRKICNHPDLVEHKTLSKKAGYEYGIGTKSGKMQVVKELLKIWKDKGHKTLLFAQHRIMLDILERFIGSMSGINYRRMDGTTDIKHRQDLVNEFNHDPDLHVFLLTTKVGGLGVNLTGANRIIIYDPDWNPSTDVQARERAWRLGQKREVEIYRLMTAGTIEEKIYHRQLFKLFLTNKILRDPKQRQNFQLKDLHDLFTLGESVDGQTETGTIFKGTEVKLKRGNSLPTPPDEDEKQKETERVAINDFAGVSRQEDFRGDKDEHNKNNKSEGADQSSSDRVLSGIFARAGVQGAQDHEAIVSGRRAPRADPEMIRKEAKKIADEAARELKRAAEIARSLPAGIPTWTGQVGTAGRPDSPPPRRGGGSMRGGMSSRGRGGPSSSSVLANLQHRQANASNTTMATTSSRDGNIGTATRGGRRAANDDRNLPQGLDFMTLIRDYISSHGGAVYSQMLVDHFNRYCNNSPKRTAEFSEMLKKIAVMEKGGRMRAKWVLREEYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M3CFT6</accession>
    <name>M3CFT6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_15246</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760794.1">
        <property type="nucleotide sequence ID" value="XM_016907457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CFT6"/>
    <dbReference type="STRING" id="692275.M3CFT6"/>
    <dbReference type="GeneID" id="27904594"/>
    <dbReference type="eggNOG" id="KOG0226">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_29_0_1"/>
    <dbReference type="OMA" id="WHAQYAP"/>
    <dbReference type="OrthoDB" id="10020333at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050825">
        <property type="entry name" value="RBM42_RBP45_47-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640:SF11">
        <property type="entry name" value="RNA-BINDING PROTEIN 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="134"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="204"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="219"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF12673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="231" mass="25418" checksum="C40519CC1F840EB5" modified="2013-05-01" version="1" fragment="single">GQYAAPPGYGGQYTQQAQQFETPPQIRNPFMPPPPAASTYAAHNSNFDPDHDAQIAQWHAQYAPAEQQFRGKKMGKDEPVGNANLAPLGQRGSGAAPTVAEAEEKDDGKFTVIRKGGGEQWEDRSLLEWDPTKFRIMVGNLAGEVTDDSLAKAFANYGVSKARVVRDKRTTKSKGFGFVEFQEGELGFKAAREMVGKYIGSHPVTIQRSKTDVRPAVRKDKHKGKNNRNND</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M3CHE6</accession>
    <name>M3CHE6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">D-aminoacid aminotransferase-like PLP-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_125069</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761339.1">
        <property type="nucleotide sequence ID" value="XM_016901952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CHE6"/>
    <dbReference type="STRING" id="692275.M3CHE6"/>
    <dbReference type="GeneID" id="27899089"/>
    <dbReference type="eggNOG" id="KOG0975">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020844_4_1_1"/>
    <dbReference type="OMA" id="WRGSEMM"/>
    <dbReference type="OrthoDB" id="25921at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.10.10:FF:000002">
        <property type="entry name" value="D-alanine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050571">
        <property type="entry name" value="Class-IV_PLP-Dep_Aminotrnsfr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42743">
        <property type="entry name" value="AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42743:SF11">
        <property type="entry name" value="AMINODEOXYCHORISMATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF13218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="299" mass="33082" checksum="574E39E37D6E9817" modified="2013-05-01" version="1">MHSARIPILDQGFMRGDMTYDVASVWNGRTFRLNDHLDRIERSSQKMRYRIPLSRPKITNLIAEMLSLSGIRDAYVCLMVTRGMERVSNNPAIGKKAEELQNTLYLWITPYVWVMSPEMQMGGGGRAIVARTVRRIPPGAFDPTVKNLQWGDFTRGLLEAADRGAEYPFLTDGDGNLTEGSGYNICVIKNGVLYTPDRGVLEGVTRKAVMEVAKAQGIEVRVEVVPVELVYQADEIFMCTTAGGVMPITELDGKKVGNGKVGKLTGSIWDGYWASHLDDKLNVEIDYAAGASSSIRSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M3CHS1</accession>
    <name>M3CHS1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peroxin 26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_148671</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761454.1">
        <property type="nucleotide sequence ID" value="XM_016905070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CHS1"/>
    <dbReference type="STRING" id="692275.M3CHS1"/>
    <dbReference type="GeneID" id="27902207"/>
    <dbReference type="eggNOG" id="ENOG502S0P1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046457_0_0_1"/>
    <dbReference type="OMA" id="RNDEWEY"/>
    <dbReference type="OrthoDB" id="3981028at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="398"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="320"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF13333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="447" mass="49566" checksum="164D1AFCD81606FD" modified="2013-05-01" version="1">MASTGTITYQDALDSQYLSSSMSSLSRSRSTNSLIVRTYKQATQLYLTKRFKEALETLEPIITAPQSSDVPAHDDATTEGGEYTGGAAPVAQSSKGTRTKVWVFYLSLLHAIIDLGAEQGKNLFGSAKWRQLAAKAREGSVWDEIVRLGYGGNEGDVDPDVVVNLATLLLGHMQHQRLNQQRLEAYLSASADAAQLAYLNEGIATPMSNGTSSPKELTTRLKILELYTLHALPANDEWDYAQQFIEMNDMLDEERREAFLHALASFKEEKDGTAQRERELEELRERELEEQRAAEEAQRKEQERQDEERKKAAELERARGANAPSASSSARPTNGHKAGHATASSQRPSAQSTSKPPSKPQKKARAPPPSLYARATSVFSNLQQMLLDASRGMTGNNMALFRLLMFLTAVLLIIARRDLRMKLKRGLEDSWTKVKQTVGMGTKVSYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M3CI51</accession>
    <name>M3CI51_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_148748</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761589.1">
        <property type="nucleotide sequence ID" value="XM_016905127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CI51"/>
    <dbReference type="STRING" id="692275.M3CI51"/>
    <dbReference type="GeneID" id="27902264"/>
    <dbReference type="eggNOG" id="ENOG502SM1S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020425_2_0_1"/>
    <dbReference type="OMA" id="DARDTWW"/>
    <dbReference type="OrthoDB" id="422736at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22997">
        <property type="entry name" value="GT_LH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36587">
        <property type="entry name" value="EXPRESSION SITE-ASSOCIATED GENE 3 (ESAG3)-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36587:SF2">
        <property type="entry name" value="EXPRESSION SITE-ASSOCIATED GENE 3 (ESAG3)-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF13468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="492" mass="55252" checksum="4FE7EEBB47D022E8" modified="2013-05-01" version="1">MLQLGKNGRSLLLIFSSLFVLLLFFVSLHPPTRTLLHPLHGVADKPRGFHFLLPTTSTNSEVCKLIGSGTILGYPAPSLLGWEGRGRWNGSESHLFKLSETLFYLNTLRKEQDDDLVLLLDAFDVWLQLPPHVLIARYNRAIAKENEILRRDGLLDRPAPDGTPIRNTILFGVDKFCWPQNGEVIPCWAAPNSSLPDDIFGPGTDGGEDVKLRPRFLNSGSIMGPVKDIRNLFRTTIEQIDLEWDDDFIHKTSDQHYLSILWGDQEEARMAVRNGTGRLLESQSAMEFHMAVDHASDAFQVNNWNSQYMTWMTFNHSTRDNTSQAARSLGRLDQLQLDPEITSSPGPFSAADPDDATDGLPVELGWEDVSLGTNTATGEVFPLYHITGNKLVRGQWWPRMWFHPHGEALLKAARKKWLAKVHSAGHFEVADVGGIKYTAVQPNNGDIFQNMRARDKSNAKGGAWNDLGEFMSWNEICGREEKAVFLTRVVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M3CIA2</accession>
    <name>M3CIA2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CST complex subunit Stn1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_148803</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Telomere</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761669.1">
        <property type="nucleotide sequence ID" value="XM_016905156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CIA2"/>
    <dbReference type="GeneID" id="27902293"/>
    <dbReference type="eggNOG" id="ENOG502RY83">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054798_0_1_1"/>
    <dbReference type="OrthoDB" id="77828at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd03524">
        <property type="entry name" value="RPA2_OBF_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018856">
        <property type="entry name" value="Stn1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10451">
        <property type="entry name" value="Stn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="CST complex subunit Stn1 N-terminal" evidence="5">
        <location>
            <begin position="65"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="140"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF13548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="193" mass="22286" checksum="60EA4028702DCE83" modified="2013-05-01" version="1">MVAGGKFILLTVDDGSGANMEVKLERPVAHRAPSGAVYSTKTTLDHVEAIIEMGLPAVYIRGKRVEIGSVVIAEGKVEKYNTSRQLIAQRFNFVKDTHDEAVYWSKVAEWKRKVLNKPWTLDTETKRAIDMKLKEEERVREKNARRKKKRSAKVEEMRRLHDEKVEQKRKERTEYYDQGALAGTNVLKMPWDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M3CL22</accession>
    <name>M3CL22_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_148183</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762604.1">
        <property type="nucleotide sequence ID" value="XM_016904759.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.M3CL22"/>
    <dbReference type="GeneID" id="27901896"/>
    <dbReference type="eggNOG" id="KOG2294">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_244233_0_0_1"/>
    <dbReference type="OMA" id="SYYMHTY"/>
    <dbReference type="OrthoDB" id="5402974at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060962">
        <property type="term" value="P:regulation of ribosomal protein gene transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045178">
        <property type="entry name" value="Fhl1/FHA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21712">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN FHL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21712:SF29">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN FHL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="5">
        <location>
            <begin position="789"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="3">
        <location>
            <begin position="789"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="253"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="474"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="873"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1041"/>
            <end position="1451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="263"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="475"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="499"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="516"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="531"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="547"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="584"/>
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    </feature>
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        <location>
            <begin position="597"/>
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    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="616"/>
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    </feature>
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    </feature>
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        <location>
            <begin position="1085"/>
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        <location>
            <begin position="1104"/>
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            <begin position="1234"/>
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        </location>
    </feature>
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        <location>
            <begin position="1276"/>
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        </location>
    </feature>
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        <location>
            <begin position="1304"/>
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        </location>
    </feature>
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        <location>
            <begin position="1354"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1381"/>
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        </location>
    </feature>
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        <location>
            <begin position="1399"/>
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1425"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1441"/>
            <end position="1451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF14483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1451" mass="154727" checksum="A052F3064268D9C5" modified="2013-05-01" version="1">MEDSGLAFAAPASYLPDGLAMKDNSNHLAMQQMDLPDTANIFATPVRNTVGHGAGTGAQEQAGSGSHSLNIASDGDGVRQSEGGQMNAPAANETCVASASKTVDSKLERSQLDYSTLDTPARPTVDHGIESGVRDTLDMSLPDCGVFKVESVPPGNPANLELYESQDGPPTNGELPETESMADPSTPSVAQGAFTASPTIAEEEPSVHQAYAMLKFPDSYYYVKSTNVMITRDETFYRVYRESKRQKRLRAKMQRAAQQTLDDYAREPSHHSQHGGDDEDDEDLMGRPAHGLLSAYSDAGGPVSYVVKPDNDFVSFDSPPLVHRARKSKHNSSSNHSIAPRSLHEFEQGAELEGDLYLDKEGRLHDPHEWAQVAIHPQDPKDIEKISREHLIIRYDADKRSWVMDVIGNRVLHNGELRNRGESDIDLSHDDEIIIISVSFRFMLPADEGIDVMESVECDDDEFETSLAARRISDTIDDIESDEDADSSEEDVPLAQQTKPKKLKVKVPKNKEPKPKPLKLKLKNKQASKNAEVKIADTHGKKDKVTGKTPAKAGGKTGGKTPAKATKAVAKAEPTPDARPPPTEAEASKATTKAADEQQSAPSTEAQLVEFAQAPPAGPPTQASPPAPINLDPNSAFAGADPSQLPQKRKGPGRPPKNGLISKRDDAGVKRKIKEYERQNLPPPPMNELLEMVRVEQRQKDAAAKAASRGEATPDMVIQNMDPRMPNYSVPYASAAPSQPAQSLPAGTNSPHDLPQSAARSTSPRPRRPAKSPSPMPAQESFTEEQLKKPTITYVFIIDEILQDPALDGQADLQTIYDKIQKRWPYFKYGTSTNGWQSSVRHNLLQCQRFVESGKSGKGKYWKINFEHELDPKKRKQATPPPQHPPQSGSGGPPYSQPYNVPYQQANNMYSSPYNPGAYPGAGPAGGAQAPPSGPPASGPYPQQTHYGSQPPNGNRMPPQQPPAPQPFATIVQAIVAYKPQFLQPHVGKDTHARAEEQFNQALNHYSELHAGNTPTTEGQIDESQDPFRTMKQIFIQYGQGDTRGTQSNAPTPAPNAAPTANAVPAAPGKVTSHAPAAVMGGSGAPAIAGTTTTPVPQVHPTQNMTSSQPLTAAPGVNSSTAMPFSQQMQPPAMSGIQPKPPTSGPGPSNIQPTATRPVSTASMQNASIIPVAGAATQSQPQTAPTPMQVAPPRPLATGSQTGTSSAAGGAPRFQPSAAPSISSSQNGQQQTNRVASPSSASLPRPPPVQRPQQTTNAGISPPPVVPAHQPGPTIQAHAPAPQARAQLGPLQRPTPNVVGGATKPQQHVSSPSGPAPLAQLSSPVPPQQCKPDQKLAQTGSNVISPALPRVNGFQAQSMDRNDANQGALTDVRPPPAGVKRVADHSDEDQAAKRPKILSANQAPDANSALETTPYEKSPSAGAKRTADESMDSEAKRLKTTQESAATPAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M3CN44</accession>
    <name>M3CN44_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_147149</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763339.1">
        <property type="nucleotide sequence ID" value="XM_016904115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CN44"/>
    <dbReference type="STRING" id="692275.M3CN44"/>
    <dbReference type="GeneID" id="27901252"/>
    <dbReference type="eggNOG" id="ENOG502SP0G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056959_0_0_1"/>
    <dbReference type="OMA" id="CYELAMQ"/>
    <dbReference type="OrthoDB" id="9986881at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF1">
        <property type="entry name" value="PYRIMIDINE PATHWAY REGULATORY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="49"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="165"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF15218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="438" mass="47336" checksum="EF49C16668B483D2" modified="2013-05-01" version="1">MSTAASSPTDAVSAEDLNRLPLQRRATIGDPMQDNPAITRQRRKSSIIACDRCRRRKIRCDGNQPCATCARFGVRCARQEQRRERSCSNAEHTDLADRVRALEAGLAAVTAGEHINPSHKRPGPPSLQLNTSLPTDLSPAFSYAGGIDHMSLSDEILPQNVPTIHITGPHGGSNTAPPSALSPSPSLISETSGASSPDPFSSVSAFDFGNSSLCASTLMPAANGFVPTPPLNQWAEVYNQNLHTPTSPGSQHISRRSSVSSFGGLGEAIYAMDLHNSDWSMQGSFADSDANDFDNMGYILSDPIPSKPQAEILAEKVFSNRCLLIDRPTFRVCLEAIYMLPDHTSDAHPAVNDKLSSYTSFSLRVARCLVFLVLTIGLRMQSFEQSISNSNSIVQEQSCYRLAMRQMASSIDFWSENGTKEVMALLGVLAEVSSSSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M3CQB9</accession>
    <name>M3CQB9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glycerophosphodiester phosphodiesterase</fullName>
            <ecNumber evidence="2">3.1.4.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_147633</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a sn-glycero-3-phosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12969"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:83408"/>
            <dbReference type="EC" id="3.1.4.46"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycerophosphoryl diester phosphodiesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.46" evidence="2"/>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763999.1">
        <property type="nucleotide sequence ID" value="XM_016904429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CQB9"/>
    <dbReference type="STRING" id="692275.M3CQB9"/>
    <dbReference type="GeneID" id="27901566"/>
    <dbReference type="eggNOG" id="ENOG502QW99">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036449_0_0_1"/>
    <dbReference type="OMA" id="GGWYYQS"/>
    <dbReference type="OrthoDB" id="1058301at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008889">
        <property type="term" value="F:glycerophosphodiester phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43620:SF7">
        <property type="entry name" value="GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE GDPD5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43620">
        <property type="entry name" value="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004032027" description="glycerophosphodiester phosphodiesterase" evidence="8">
        <location>
            <begin position="20"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="9">
        <location>
            <begin position="114"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="47"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF15878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="465" mass="50907" checksum="51BDBD25A35C83CF" modified="2013-05-01" version="1">MPSSLKLAAVTLAIGLTAAAPAPVKRQDNGFWSAGKYEGAGTSYNDGKWSPGQYPGSEQPVTPHPYRGHAKSQPEKSLNVQVGPRPYFLVDNMDDGPLKEKLESCSEGPFETTSFSISHRGAPLQFPEHSKEGYEAAIRMGAGIVECDVSFTSDRELVCRHSNCDLHYTTNILAVPELAAKCSEPFVPYNNETGELASAKCCTSDITLKEFKSLCAEMEGGTFNAMNTTQYNGRLGQTPDWRTNLYAYACAEPLSLKEQISLVDSYGLNFTAEAKTPEVPLPFDGNYTQELFAQQIVDTFDEANIDPSRVWLQSFLPADIFYWIDNAPEYGLQAVYLDERADLNATGYDEAVASLPGLAARGVKIIAPSIWQLVTADNETQEVIPSTYALAAQEAGLDIITWSFERTGPLEDGGGYYYSSVSNLINNDGDELTVLDVIVQKVKAIRIFADWPGTVTYYANCFGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M3CR93</accession>
    <name>M3CR93_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_11533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF16183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764304.1">
        <property type="nucleotide sequence ID" value="XM_016901153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CR93"/>
    <dbReference type="STRING" id="692275.M3CR93"/>
    <dbReference type="GeneID" id="27898290"/>
    <dbReference type="eggNOG" id="ENOG502RAW0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042941_6_0_1"/>
    <dbReference type="OMA" id="FRVSHIN"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF13">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF16183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="171" mass="19479" checksum="BCBC5CB60A6F11AF" modified="2013-05-01" version="1" fragment="single">LDRTLALSTYSNHRVNATSRWTAPPSKEVDHAWNELGVKDMGFLLPGAIGREYGLDPRKHVYAPKGTLSNDTDGFPVFIQALHDVHCLNELRRALYYNKDYYPSQRSSVIPCQDADPQVIDHCLDNVRERLMCSADAGIIPSVWTSKDENFPLFGSQHKCHSYDALMEWNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M3CW65</accession>
    <name>M3CW65_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acyl-coenzyme A thioesterase 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_53901</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl coenzyme A hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756503.1">
        <property type="nucleotide sequence ID" value="XM_016909279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CW65"/>
    <dbReference type="STRING" id="692275.M3CW65"/>
    <dbReference type="GeneID" id="27906416"/>
    <dbReference type="eggNOG" id="KOG2763">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032862_1_0_1"/>
    <dbReference type="OMA" id="QFNYTFL"/>
    <dbReference type="OrthoDB" id="331699at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03442">
        <property type="entry name" value="BFIT_BACH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000032">
        <property type="entry name" value="Acyl-CoA thioester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000038">
        <property type="entry name" value="Acyl-CoA thioester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033120">
        <property type="entry name" value="HOTDOG_ACOT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12655">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12655:SF0">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51770">
        <property type="entry name" value="HOTDOG_ACOT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="HotDog ACOT-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="HotDog ACOT-type" evidence="5">
        <location>
            <begin position="205"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF08382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="381" mass="42691" checksum="D566D6265363AAB6" modified="2013-05-01" version="1">MSDSYHSVVLPLAQEPWLLDTYMNASGHLRIGTILMDLDALAGVVAYKHTGDHVTTVTAAFDRITIEHPLTEVCDLEYSGQVTYASGRSSMEITLQVAKAPSAGQKPRPEDIMMTCQCTMVSLDPATKKPVNIAPVRTDTPEEKRVFAEGEKNGQRRKELAKRSLLKQTPNDEESDLIHAIWQRQLQYHDPADHARKPANAHFMDSTQLRTASIMQPQYRNRHHFMIFGGFLLKQTFEIAFCCAASFAHTRPTFVSLDPSTFQNPVPVGSVLYLTATIVYTDPPLISGQAEQQPTTEGRPANAQTRVQVRVDSKVRDVEHGVAKPTGQFNYTFLVDKDIKVLPRSYTEHMMYIDARRRAMSVREKVQQGDADSGSSERITE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M3CWI8</accession>
    <name>M3CWI8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_152140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756613.1">
        <property type="nucleotide sequence ID" value="XM_016907265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CWI8"/>
    <dbReference type="STRING" id="692275.M3CWI8"/>
    <dbReference type="GeneID" id="27904402"/>
    <dbReference type="eggNOG" id="ENOG502SS5H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099515_0_0_1"/>
    <dbReference type="OMA" id="MMFPPVL"/>
    <dbReference type="OrthoDB" id="4868994at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF08492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="139" mass="15226" checksum="67108D5758A1495F" modified="2013-05-01" version="1">MPMPGELPKDAEEAKQGLFAYAKAWGENPLPATLLATLISAQHMRPFQTIPMLFPPILVFSSYLNVQGFKKDSAGLMSAWSMAYFVLARRRQVKLGQKITVRGATRGVTMGLCAVNALTGGWAYWKGNRDEKPKPLVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M3CX47</accession>
    <name>M3CX47_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="9">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_52834</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756813.1">
        <property type="nucleotide sequence ID" value="XM_016909243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CX47"/>
    <dbReference type="STRING" id="692275.M3CX47"/>
    <dbReference type="GeneID" id="27906380"/>
    <dbReference type="eggNOG" id="KOG2204">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003818_0_0_1"/>
    <dbReference type="OMA" id="FEWADWE"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF103">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MANNOSIDASE MNL2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="426"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="453"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="539"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="383"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF08692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="549" mass="62463" checksum="153E0F976AC5AFC2" modified="2013-05-01" version="1">MPGRNRRVRLLAIAACIITIFFLYERNTSSSYLSPIPVHWSKQPERWPVTSTIQLPTGTPVPIPRIQSAKRGADVNRLRAIKDAAKHAWKGYRDFGWGFDEVAPVSGVGKNSFNGWGATLVDSLDTLWIMGLKDEFEDAVNQTSYIDFTTSSRNDIPMFEVTIRYLGGLVAAYDVSGQKYRVLLDKAVELAEILYSAFDTPNRMPETYYYWKPTFASNGHRASTRVVLAELGTLSLEFTRLAQITKEPKYYDAVARITDALEEWQNKTRLPGMWPISVDASGCAKPGLRAPGTTSAQTFTMGGQSDSVYEYLPKEYLLLGGHLDQYKTMYLNSMKPTIEKLMFRPMTPGDLDILISGEVTIQNNYTTGEWYETHTPKAEHLTCFIGGMLAMGGKIFSLPEHVEIGRKLTDGCIWSYNSTTTGIMPESFFATPCNSTTECQWNETDKKYILRPEAIESVFYMYRITGEQHWRDAGWEMFKAVEAHTRAEFGHSAIDDISKAHPEHVNGMESFWIAETLKYFYLLFDEEDKWSLDDWVLNTEAHFFRRPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M3CZH2</accession>
    <name>M3CZH2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PLP-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_93519</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF09071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757192.1">
        <property type="nucleotide sequence ID" value="XM_016910621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CZH2"/>
    <dbReference type="STRING" id="692275.M3CZH2"/>
    <dbReference type="GeneID" id="27907758"/>
    <dbReference type="eggNOG" id="KOG2142">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010913_2_0_1"/>
    <dbReference type="OMA" id="NTAICED"/>
    <dbReference type="OrthoDB" id="10264306at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008265">
        <property type="term" value="F:molybdenum cofactor sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043545">
        <property type="term" value="P:molybdopterin cofactor metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237:SF80">
        <property type="entry name" value="MOLYBDENUM COFACTOR SULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SULFURASE MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="2">
        <location>
            <begin position="48"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class V" evidence="2">
        <location>
            <begin position="191"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="516"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="609"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF09071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="655" mass="72365" checksum="1B0D61934FA143A9" modified="2013-05-01" version="1">MTLTPPDLTELGGTPTGRVMAERDSKNPIEDSMDMLRLLEYPQLMGRTYLDHAGATQPAKSLNTAICEDVSQNLYGNPHSEHSPSQLAHHRIQETRLKALEFFHADPHEWDLIFTQNTTAAVKLVHDCFRDHAAAPPGGGAGRNWWFGYHKDSHTSIVGVREGTRLHRCFRSDREVDLWIESRGLGGAMVHDVGLFAYPAQSNMTGRRLPLDWPARIRSRVKAETYTLLDAAAYTSTAELNLSDTARAPDFVALSFYKIFGAPYIGCLLVKKSARKVMESRRYFGGGTVDMVIAVNDSWVKRKGKIHLHERLEDGTLPCRQIFELDHAIDIHRKLYGPSPMKHISMHTTRLIKKLHDDLVSLRHSNGLPVVKIYKDSGSVFGEAHLQGATIAFNIQKDRGGLVRYFDFEKEANAQDIHVRSGSLCNPGGTATYLQWSPTELREAFAYGHSCSSPQAEYSGKALGVVRVSLGAMSSDADIARLVQFVRETYVDRVYDSGGPICLPGDVMADAPISTKSRASAKGSHVSDQKEVARMSSRISSDSTCTLTAETALEQQQQQQQQQQQQVVGVVGVVALAGAVAERKGPSFLKAGDLLLTPTADAMAREASLTSSTSNVSKEEEMCSMKSKASRTERLRKSIGEVFRRGSRRQGTHVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M3CZI3</accession>
    <name>M3CZI3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">threonine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Threonyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SEPMUDRAFT_151921</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="3"/>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF09081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757202.1">
        <property type="nucleotide sequence ID" value="XM_016907126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3CZI3"/>
    <dbReference type="STRING" id="692275.M3CZI3"/>
    <dbReference type="GeneID" id="27904263"/>
    <dbReference type="eggNOG" id="KOG1637">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008554_0_1_1"/>
    <dbReference type="OMA" id="WYADGMY"/>
    <dbReference type="OrthoDB" id="5423599at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01667">
        <property type="entry name" value="TGS_ThrRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00860">
        <property type="entry name" value="ThrRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000003">
        <property type="entry name" value="Threonine--tRNA ligase 2, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000006">
        <property type="entry name" value="Threonine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000005">
        <property type="entry name" value="Threonyl-tRNA synthetase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047246">
        <property type="entry name" value="ThrRS_anticodon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451:SF46">
        <property type="entry name" value="THREONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="THREONINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGS" evidence="14">
        <location>
            <begin position="48"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="317"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="556"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="562"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EMF09081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="757" mass="86294" checksum="F6E5C2ECAB3DBC06" modified="2013-05-01" version="1">MGKDKKADAGDSRPLELTPPPEFFATRNALFDKRKAEQDEWKAKQPREPITITLENGSTKEGTSWETSPAQIARDISKSLFERTIIARVDGDELWDLDRPLEKSCKLELLDFDHPEGKKVFWHSSAHILGEACEKRFGCSLCIGPPVEDGFYYEMALPDQAAVTSADYKPIKQIAEKAIKEKQPFERLTLSKEDLLEMFSYNKYKKHIINDKIPDGTSTTVYRCGPLIDLCRGPHVQHTGRIKAFEIMKNSASYFLGDAKNDSLQRIYGVSFPDKKALEEHKHFLEEAAKRDHRKIGQEQELFFFHQMSPGSAFFLPHGMIIKNALGTFIREEYWKRGYQEVGSPNMFNSALWKQSGHWQHYQDDMFTFEVEKDQWALKPMNCPGHCLLFGHRERSYRELPMRIADCGVLHRNEASGALSGLTRVRRFEQDDTHIFCMESQVEQEVKALFDFMTAVYGLFGFSFKMKLSTMPDNHLGDVATWQRAEAQLASALDEFKANTGTQWELNPGDGAFYGPKIDVTISDALRREFQCATIQLDFQLPQQFNLEYRTDEVATAVKPEANGEKPATDAPKPEEKTLPIHPAPTAETGDVSAAAATPAKPEVNYRRELTPGCARPVMIHRAIYGSFERFIGILTEHFGGKWPFWLSPRQILIVPVMPSANDYVLELQSEFRAAKMHVDVDITGNTMQKKIRTGQLAQYNFIFVVGAQEKESRTVNIRNRDDPTTQKMGELIPVDKAMELLIKLRDERRLNSDLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M3D049</accession>
    <name>M3D049_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">7-dehydrocholesterol reductase</fullName>
            <ecNumber evidence="18">1.3.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Sterol Delta(7)-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">SEPMUDRAFT_91478</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>7-dehydrodesmosterol + NADPH + H(+) = desmosterol + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:46740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17737"/>
            <dbReference type="ChEBI" id="CHEBI:27910"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:46741"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>cholesterol + NADP(+) = 7-dehydrocholesterol + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23984"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:17759"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.21"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="21">
            <dbReference type="Rhea" id="RHEA:23986"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Steroid biosynthesis; cholesterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 23">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.21" evidence="18"/>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF10259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758380.1">
        <property type="nucleotide sequence ID" value="XM_016910556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D049"/>
    <dbReference type="STRING" id="692275.M3D049"/>
    <dbReference type="GeneID" id="27907693"/>
    <dbReference type="eggNOG" id="KOG1435">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015631_0_0_1"/>
    <dbReference type="OMA" id="WGKPAEC"/>
    <dbReference type="OrthoDB" id="5326588at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047598">
        <property type="term" value="F:7-dehydrocholesterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016132">
        <property type="term" value="P:brassinosteroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006695">
        <property type="term" value="P:cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000004">
        <property type="entry name" value="7-dehydrocholesterol reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018083">
        <property type="entry name" value="Sterol_reductase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF38">
        <property type="entry name" value="7-DEHYDROCHOLESTEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01017">
        <property type="entry name" value="STEROL_REDUCT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01018">
        <property type="entry name" value="STEROL_REDUCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0152">Cholesterol biosynthesis</keyword>
    <keyword evidence="5" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 23" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="14 23" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="12 23" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 23" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="17 23" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="13 23" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="16 23" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="6 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 23" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="394"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00038851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00039984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00042688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="RuleBase" id="RU369120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="EMF10259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="454" mass="51652" checksum="2E6831A45374D064" modified="2013-05-01" version="1">MEQVLETIVPEKAKPVLWGAHSNKAKWESLIGVLAIITCCPVLCILNWVALEQYGGSLFDCMSAALDYGPGPVLYVIDHLPKPSQAAVAGYAGWLLFQAILYGALPGEICFGQQTPAGHQLHYKTNGLLAWTLTHALYIGASWYGYIDPALIANNWEGLLVAVNVYGFALAILAQVKGHLFPSHPEDRKFSGSLIYDFWAGVELNPRFGSYWDFKFFHNGRPGIVAWTLINFSWAAYQYQRLGYVTDSMVVVNILQAVYVVDFFCNENWYTRTIDISHDHFGFMLAWGDTTFLPTFYTLQAQYLARYPTHLSRGQAAGILALGLFGYSIFRSANYQRDHVRSKQGEARIWGRPAEFIRCKYHTSDGKEHTSLLLTSGWWGVARHSNYLADLVQSFAFCMTCGFTNIMPYSYFFFMCILLTHRARRDERRCRAKYGEKWDQYCRTVPYTMIPGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M3D072</accession>
    <name>M3D072_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="1">4.3.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_150987</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.3.2.9" evidence="1"/>
    <dbReference type="EMBL" id="KB456268">
        <property type="protein sequence ID" value="EMF09883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758004.1">
        <property type="nucleotide sequence ID" value="XM_016906526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D072"/>
    <dbReference type="STRING" id="692275.M3D072"/>
    <dbReference type="GeneID" id="27903663"/>
    <dbReference type="eggNOG" id="ENOG502S329">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030506_1_0_1"/>
    <dbReference type="OMA" id="CFAGTQY"/>
    <dbReference type="OrthoDB" id="2017317at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003839">
        <property type="term" value="F:gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017939">
        <property type="entry name" value="G-Glutamylcylcotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935:SF0">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="138"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="78"/>
            <end position="83"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR617939-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617939-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF09883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="388" mass="43116" checksum="94CEAF6382C448E0" modified="2013-05-01" version="1">MMETDQPPANRAAISAYTSSHAILDRTSRSQPHPELRPSLHHRTPPPCSQRLAATVNDRPYDVARFVKEHSKEETVLYLAYGSNLAYEKFQDPNGRGIKPLAQINVQVPTLRMTFDLPGIPYIEPCFANSAIREPEHRPFGRDGVDEKSSLLHGSSRSQDYRKDRWHKGLIGVVYEVTAADYAHIIATEGGGASYQDILVDCYPLANDPRDAVPPTPITAPFKAHTLFAPAAPDGEEPPKDGGRFQRPDQAYAQASARYLKLLTDGAEECELPYEYQEYLHSLHAFTITTMRQRAGQAVMLATWVPLVLLLFQIAKLFADENGVLPDWLSGVFGVTFKAVWISYDMVLKPIFGEGERTIGDVGDAAEQLSRDGSFDIEKAAVTSNMNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M3D0X7</accession>
    <name>M3D0X7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_150150</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759259.1">
        <property type="nucleotide sequence ID" value="XM_016905988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D0X7"/>
    <dbReference type="GeneID" id="27903125"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="OMA" id="FPPHRWV"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF36">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="437"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="472"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="472"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="488"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF11138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="502" mass="56008" checksum="F64C12A578308092" modified="2013-05-01" version="1">MANVSEKNGDHHAADVEKQIEPVNKQEAESIEPFVLPTEEEKRAVIRKLDWRLLPLVFVLYSLAVLDRSNLGNARLAGMEQDIDLSGNRYELLGTIFYIAYIVSQWTILGWKQFKPHQWCAFTIVFWGFVATVQAAAFNWAGLMTCRFFLGVSEAMFGPGVALYLTYFYPRQKVGFRHGVFISGAAMANAYGSALAYGISQIRGSLRPWKILFLIEGLPTIAMAVVVWFFLPDRIDSASFLNEREKQVASHLVAQNQKVDVGKERGVRWRETLDAFKDPKSFIPGLMYFGCNVSFASLPLFLPTIISEMGTFSTITSNGLSAPPYVFCFLVILLISFLSSHYHSHGPFVALTATLAAVGFIINATTTTTGPRYFSTFLSVCIFASIGVLLSWTANLHATESKRGGGYVILNLVGQCGPLLGTNIFPESEKPLYRKGLWVSAAMCLMVAVLAVLLELWIGYEKRVMLKGKNHEEQLQREEEEKKEELELSGLRSRSSGRSITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M3D255</accession>
    <name>M3D255_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_118502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456266">
        <property type="protein sequence ID" value="EMF11202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759323.1">
        <property type="nucleotide sequence ID" value="XM_016901433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D255"/>
    <dbReference type="GeneID" id="27898570"/>
    <dbReference type="HOGENOM" id="CLU_1994040_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF11202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="134" mass="15595" checksum="D2206A55F214D172" modified="2013-05-01" version="1">MPKRKSNAPEALANKRAKLGAASKSLEEYSLKPNTLRDRERTAAIDEEKRAQIKEYTSFESLAKDKQQELIEGWRKIHTKEYDQKAIKKQTGKSTTLPPDKQAKIDEADWFLELGDIDSKERLTFQKEDQIKWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M3D2I3</accession>
    <name>M3D2I3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dilute domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_149104</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760541.1">
        <property type="nucleotide sequence ID" value="XM_016905344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D2I3"/>
    <dbReference type="STRING" id="692275.M3D2I3"/>
    <dbReference type="GeneID" id="27902481"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007327_0_0_1"/>
    <dbReference type="OMA" id="WSQVMYW"/>
    <dbReference type="OrthoDB" id="426293at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051020">
        <property type="term" value="F:GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15473">
        <property type="entry name" value="Myo5p-like_CBD_DIL_ANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037986">
        <property type="entry name" value="Myo5p-like_CBD_DIL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052072">
        <property type="entry name" value="Vascular_dev_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027:SF6">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN YPR089W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01843">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01132">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51126">
        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="185"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="218"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Dilute" evidence="3">
        <location>
            <begin position="411"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="695"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="807"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="720"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF12420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="831" mass="93564" checksum="B719648D3F5438AB" modified="2013-05-01" version="1">MDAEAGHVGRRHDGRDEHDDDEAAAVVVEEDEDGAQQEKKRPMELPADLPRSLDDRQSYSYGPPQETEYYDAWQGQSQFLTAPTIAKPFNLSLNEPDDDAFERDFGHDDVGVAEMMAIHARKQSDAAESQEDDILHDDKLSREEKAQALQDFLFMAASNGDSARVHRLVRGPASKFTQIDGVDAEGTPPLVYASCFGHKDVVQTLLDAGATVDCQDKNQWTALMWAITNSHKDIAKILLDHGASTDVKSSSGRTPLDFVPPGGEMSDFLQDSGYRIGTVGVTDDFYNAGFSQDRFEEELAESEQRRRMMMESAINLEVDLGNLGLDETPESPEDFEDTDEFDWTRCLNDQMFVFVENDIERILDVVITKMTPQRSATQKPVPANIVFLGARYAHYHSSAELLTDWLATAQDKIYDIVDRNQWDMTMLAFWLSNATLLLYYLKKDTGLTEATTQFQAQMAELVHEIYILIIRDAERRMDKVLDAAMLDHETIPGFEDITFQNEWKFLKKKNTVKPEPMEKRFRPPSPKRKAQISPRNITSLLSSTLFVLDLYDVHSVIIAQVLSQLYYWLGAEIFNRIMSNKRYLARTKAMQIRMNISMLEDWARTNNRQPEHYANGETTATGEPTVETARRHLGPVVQLLQWLQCFSSMGEDRDGMETTLQQLPNLSIKQLLHAVKHYRAEVGEKSLTRPALRHIEEVKSRPKAPHPSFRTSGAGKELPSTPTTPGGAQQPNSPRNGASPLPPGTPTYDNEEDVPESNLLNPALLLPFHLPTSTDMLISYGSGFGGVNRERERRYIPSVPPEFLQKLDPGAGISQSRNNLYEGVDLGNDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M3D3I9</accession>
    <name>M3D3I9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_19197</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760585.1">
        <property type="nucleotide sequence ID" value="XM_016908313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D3I9"/>
    <dbReference type="STRING" id="692275.M3D3I9"/>
    <dbReference type="GeneID" id="27905450"/>
    <dbReference type="eggNOG" id="KOG4585">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_183425_0_0_1"/>
    <dbReference type="OrthoDB" id="5421058at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF12464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="54" mass="6815" checksum="218DDB2075741360" modified="2013-05-01" version="1" fragment="single">ELFNLRYSLLRNIVKRVFSVLKQRFYILKKRPRYNRAIQIQLVYTLYTLYNFIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M3D3V5</accession>
    <name>M3D3V5_SPHMS</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">SEPMUDRAFT_149216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016905418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D3V5"/>
    <dbReference type="GeneID" id="27902555"/>
    <dbReference type="HOGENOM" id="CLU_1120705_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF12584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="248" mass="28609" checksum="2FA4253970179195" modified="2013-05-01" version="1">MYSLGDRARYVNKSRIERIRCLEGLALARLFRGDRGQQQLLQRFLVSGKVQTRHSCREPPFILRADFQRFLAAIVSQCAPQNLYSLPRHKRPILSDVHIHLNGPPLHTMDYIAATEVTSLDCWLFSIFFIMGLVVGFYLSKLRLHVMDIRIRQWELDAARRRNVQLQLTPSQSTEKTVLKAQAGKCASTVRSARLNLSREECNSKIKSFRIRRRTDCMSHQGFLLSIAFAECTIREGVRSRILSNQCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M3D4R8</accession>
    <name>M3D4R8_SPHMS</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_140676</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761331.1">
        <property type="nucleotide sequence ID" value="XM_016902940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D4R8"/>
    <dbReference type="GeneID" id="27900077"/>
    <dbReference type="HOGENOM" id="CLU_2656043_0_0_1"/>
    <dbReference type="OrthoDB" id="4084751at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF13210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="76" mass="8701" checksum="1482948FE13CBEAE" modified="2013-05-01" version="1">MLASGWLLLLLLLLLLQLVFVSFFPFFVQKLITTEKLAAGNTGRSLLNTKILVNTKPSSDYEYRDIQIDEWIEKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M3D5N4</accession>
    <name>M3D5N4_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA pseudouridine(55) synthase</fullName>
            <ecNumber evidence="3">5.4.99.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_43582</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pseudouridine synthase TruB family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="3"/>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761576.1">
        <property type="nucleotide sequence ID" value="XM_016908900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D5N4"/>
    <dbReference type="STRING" id="692275.M3D5N4"/>
    <dbReference type="GeneID" id="27906037"/>
    <dbReference type="eggNOG" id="KOG2529">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032087_4_2_1"/>
    <dbReference type="OMA" id="FAINKPC"/>
    <dbReference type="OrthoDB" id="9995526at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160148">
        <property type="term" value="F:tRNA pseudouridine(55) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01080">
        <property type="entry name" value="TruB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014780">
        <property type="entry name" value="tRNA_psdUridine_synth_TruB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767:SF2">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE TRUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767">
        <property type="entry name" value="TRNA-PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase II N-terminal" evidence="7">
        <location>
            <begin position="64"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="259"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="412"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="307"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="412"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF13455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="462" mass="50541" checksum="D1373E8C0D469E0B" modified="2013-05-01" version="1">MSGPILEGVLAINKPPAISSAQVIRDVQNHFNPSKLFQPWLERERSRLEGESHNQRQKRKVKNRKLRDVKMGHGGTLDPMATGVLILGLGSGTKDLQYFTTECTKSYEAVVLFGAATDTYDTEGKVVGRKPYDHITKEKVEQALGPFRGKGMQKPPIFSALRVQGKRLYEYAREGKPLPEGFEIKERPVDVMELEMTEWFPGGTHEWHWPTTEADTAEKNLAKQALPGELGGVTSQGDDLSVESSEAVLKRKRSELIESQAEAAGASSPKRSRADEAGITSPSTRLSSLEGAQPNTETAEPPKDEQQPASSSAAAALTQQAQQEAEQDKPACSAPACRIKMTVTSGFYVRSLIHDLGAAVGSLACMSSLVRTRQSDFELGTNVLQYDELKAGEEVWGPKVQKLLEEWIEKKDQRSQAHDKEKQAGAAAESEEVEKEKSADGLGDGKLSDAQRISMLQKAGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M3D5V9</accession>
    <name>M3D5V9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7730 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_155625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761385.1">
        <property type="nucleotide sequence ID" value="XM_016907627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D5V9"/>
    <dbReference type="STRING" id="692275.M3D5V9"/>
    <dbReference type="GeneID" id="27904764"/>
    <dbReference type="eggNOG" id="ENOG502SSV2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_804069_0_0_1"/>
    <dbReference type="OMA" id="RTWVNIN"/>
    <dbReference type="OrthoDB" id="10256725at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056632">
        <property type="entry name" value="DUF7730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790:SF9">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24864">
        <property type="entry name" value="DUF7730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7730" evidence="1">
        <location>
            <begin position="81"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF13264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="346" mass="39780" checksum="0164F1A1BB909EE3" modified="2013-05-01" version="1">MMDLGSWSDFALRTLVAISPSPQWAHRQVEPYLGLPFGPYLRAVPPTRPRRLTEPLRPAEDSYWHKLQVFSYLEAEQRTDDQQDSSFLARLPYDVRIIIYEMVLGGKVFHCSAQNQKSPINHYVCNRPDRIDAEGARHKCSNDVYRQPSPAGDDGARSHTGLLALLLTCRKIYSEAIGTLYSSNTFVFSQNFAAFSFLKCMIPRGRLSCIRSFRLHLRIPRHPDLNSRTHQDWVQLWHFFGSEMTGLQVLHLELQMLQPTEAQIEAMDDHEAGSWIEPMVTMALDAHHERGCRVEIETRGVRHIPAQIYLQAQQENPGLDHAEILCRSCATLHEHIRFSLGRRPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M3D681</accession>
    <name>M3D681_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_148902</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761806.1">
        <property type="nucleotide sequence ID" value="XM_016905218.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.M3D681"/>
    <dbReference type="GeneID" id="27902355"/>
    <dbReference type="eggNOG" id="KOG2079">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000917_0_0_1"/>
    <dbReference type="OMA" id="NQLFFHQ"/>
    <dbReference type="OrthoDB" id="289913at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059070">
        <property type="entry name" value="TPR_VPS8_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045111">
        <property type="entry name" value="Vps41/Vps8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025941">
        <property type="entry name" value="Vps8_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616:SF8">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 8 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23410">
        <property type="entry name" value="Beta-prop_VPS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12816">
        <property type="entry name" value="TPR_Vps8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25066">
        <property type="entry name" value="TPR_VPS8_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23413">
        <property type="entry name" value="zf_RING_Vps8_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 8 central" evidence="2">
        <location>
            <begin position="784"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="domain" description="VPS8-like TPR-like repeats" evidence="3">
        <location>
            <begin position="1329"/>
            <end position="1530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1440"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1578"/>
            <end position="1612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1440"/>
            <end position="1459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1578"/>
            <end position="1587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF13685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1658" mass="182545" checksum="6151CB28CB404DC0" modified="2013-05-01" version="1">MSSVTGDAHEGGTNEDVEADESVRDAEGRIEEDKEVEEVEEVEEEDEEEEAGENEQNGEDGMAGEDSDTQTVEYGDFEEPAPHEDVLGAEDGVLPEADAAGQESGDVGESTEEGADQDFAQLDRGQNDSVDEGSADVGPNTPIAQRSPVGSALDSGSIPDDTPSRAGSLLSSPGRDASPLPRRVSERKNIMRTPSGALQPFERRFESRLSASPGSSRAQSPAFLSPHSRQISISSQLSGMSSEAGGSATDSPQVPWDVVRWTKLRKLTGQAFSESGKRSFGRPTCMAVSALIAIGTSKGLVLGFDYHQTLKIIIGPGTKATECGSVTSIAIAADYSTIASGHANGYIFTWEVSRPSRPFLHIPPLDRSVLEKRTHPDGHLENCAILHVGFLGTRHTALVSADAGGMAFSHLATRGLGPVARSINTTRLLGRYPSANPQTERARKPSSVLAFSPLPLGNVEKATDAMGLTALLTPYLLVIVSTTPIAQTQHKSPRPKDVTPHSTLSGCLAWFPAVKLKSTHADVEKGSSETKLVYCWSNVLTVLDVKVMEAQAGDVQKVPTLEFNARSRWRADEAIVAVQWLSRSVLGVLTISQRLLIIKDGTLQVTDSIDLLHRHIYHQDLFSHQLQSVVERLDSDDPSLHGVIADAFYMSYKAYKGRTFLLGFNDLTVGTLSNWADRLMALMENGDHISAIRLATEYYSGSANNVVIGLPDADAARHEVVRERNLAMISASLSYTFAQQDEERDIRLKELAEVCFEACITMKELNYLCSTVFDTFEDADEEGVFISTLEPYVLEGELTTLPPAVVTAAVAHFIGENEAARLEELLIRLDPHSFDLDQVTVLCRQHSLYDALIHIWTRALRDFVTPLVDLLTLVRMIQEGDEDEIVAENPFFESAMKIFPYLAYSLTGRWYPGGEFMDDDESYRARTDLYDYLFSGTALAWPPGGKMVFHTTQDISEEPAFPYLDLLLQFDAASFMSMLNEAFEDPFVNEPEEENGVNGGNSYNGVISGKKKGRQQIIEIMLDVMRQGDFAPPQVIYLDMFVARSMSKYPGQLILTGTLLSGILQRLCHPPLENLREDCQLSVEYLLSVYHPSDIAALIRALQQAGFYRVLKTVYRGERMLTDLLLTFFEDPEDKDKVFDCITFCLLEAPGLTSKQSEAIKEVMIKHIQDLANIDVVATARTLALCASDLLQSSVDALSDSHQQFMFLRALLEPALLRDQQASISPLPQTKHTAFVEQYVRLMCRHEPLHVADYIKTLPTSDLRLEQVLPAMENGGVIDAAVAILARDGLARDAMDRLVSHMQSLQHALASLLHAATTNPDITASPGTSDELVEDLEKYTKVGIWLCQGQSAITERIPRAPTSLASDISENDLDMDEYLWLNLIDVIVQVSQNVGASATHYEAHPLGNDQDSFDTNKLASSLRSNVQQVFTALLAATAAPNTKSTPSSSPTLALSSGSPNKQPPNRLSFLRILRAFLTRASKSAPSLSELRAVLADIFSAYTFEQSVLELAHGLLNSDVFTDIQEVHQLRQRGWRPRSQVCEHCKRRAWGPGIGEKVVWEEWILKEQERELGKVRRMMERGGGEQARRLSRGKGKMSVPSTPGIAPSGGDEEEGRKLSLVVFACRHVFHRVCLDGEFREGRLGHREMYKCPICVDDRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M3D6I3</accession>
    <name>M3D6I3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_125477</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761901.1">
        <property type="nucleotide sequence ID" value="XM_016901988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D6I3"/>
    <dbReference type="STRING" id="692275.M3D6I3"/>
    <dbReference type="GeneID" id="27899125"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014245_1_0_1"/>
    <dbReference type="OMA" id="FYWLAKY"/>
    <dbReference type="OrthoDB" id="9439903at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF12">
        <property type="entry name" value="RFEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="223"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="251"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="184"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="277"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="399"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="474"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="882"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="23"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="60"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="292"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="426"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="482"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="882"/>
            <end position="935"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF13780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1070" mass="117355" checksum="C278F6733D12ACE2" modified="2013-05-01" version="1">MDTNQYQQHAYAYGQSNGHNTNSPAAQQQQQQSSAPGQAPTLPPLQQQAGQNQNGGYSFGNLSYGQPGSQSSTPTTPHNPSMPGAQQQPHPYPQHMSPTATTGSMAPPSGYANPYNPALLYPSSSASAMPATTSALLPNIRPMPPGGMMQGNLPSLAQAGQQLGQMGQAPSFMQDEQQPTHVVGSQGRRGILPSAPGRPNPPAQGTGTAAKSMIPQKDADGKYPCPHCNKTYLHAKHLKRHLLRHTGDRPYMCHLCKDTFSRSDILKRHFQKCSLRRGNPTGANHLAHQRRNTNNGSRLSISQQDGPIGLAGMPDVNGANNSYNANVVGSSPNNVNGDLSARSSRANSLIGTGNLSQRTSLAGLGILGSNTQGADQGHQTSAPYQPGIHTYAMQNAQHAQNGSHLQHSYPFQQPPQMNGNVYHGHQAQQQQEQQMSFLGQQSSRFANSQVNNHQQMPSTSGNGVDWTRVFTQGGQDGFIGSHSANASSQGNTQIKTEPDTKQDYSVSHDFNNESFLGSLYSHPGGFGGEMTDHGIPGFPNWGMNDPLQAKVDSLLRHCFPNGVEHLQNHQAALLLQSVLKVDRLKHFAEHYTSFHGHWPILHMPTFKLTDANNNLVLAMLCIGAVYSPEIGVHQTRQLMEFVKATVYANCSIYTRTVNGQTEGLGDQASEVEELQALSMLQTTFTWHGDASQRQSARAEFPMLVRIAKAMKLCDSAPVGHQSYSFLHNTRQPQANRYQTQNWNWQSWLEQEKRNRVLYQIMVTDAAVVMFFNHTPMFDPLEIHLMLPADDAAWDATSSQECANALGLNGSQAQSKNVTGTRKSVQPSMHDAMRTLLDPYASFPLGATNAYSKFMLIHSLIIRIFNCQRALLGPDQPLQPFTLNLNGSGPATPLSQNDWLEQHNGGSSRPHSADNSGQGTPTETHSPKQQNASAAQQEKKRLGQALEKWKRSWDNDMELQYPPTDFHQRRFGFSRDGVHFFFIGRSFLQSQLASDFTLPADMRFKRVMTLLKRIKSMVVGDNENKGHDVGSVGDIDDQYGLDNLTLDMKLLFKPYNSQLDSPVAGVQTQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M3D8C8</accession>
    <name>M3D8C8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_162336</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Sodium-phosphate symporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762255.1">
        <property type="nucleotide sequence ID" value="XM_016907996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D8C8"/>
    <dbReference type="STRING" id="692275.M3D8C8"/>
    <dbReference type="GeneID" id="27905133"/>
    <dbReference type="eggNOG" id="KOG2493">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015355_3_0_1"/>
    <dbReference type="OMA" id="AYTYVFA"/>
    <dbReference type="OrthoDB" id="260807at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101:SF57">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="510"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="598"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="291"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="292"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF14134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="627" mass="67432" checksum="4E974F9148342F25" modified="2013-05-01" version="1">MAVMTEYTYVFAIGTFFALLEAYNNGANDVANAWATSVSSRSVTYQQAMILCLIFEMTGALAVGARTASTIRNGIIPIAAFNDNAGVQLLAFTCAAAGASIWVMWCTRHSAHVSSTYSLVSSIAGVGVAAVGADKVQWGWSGGSGLGAIFAGLLMAPVGSGIFAAIIFSLIKYVVHVRKNPVPWAVWSSPFFFLIAGTVCTLSIVYKGSPRLGLDEKPGYWIAGVTLGAGFALALLAAIFFVPYTYCKVVKKDYTLKLYHIFQGPRLFWRPAPPDAYKAMVPNYAVLQHSGEVTRPDEAKKSESESGSDEYTTETKGGITSGISTADSIEPSRRPSVSPPINQDSVERSAPTPQQAQADYKLQLAAARAQHHAELRQKKGPLGWAMRRLHSNPPGAGSIYEIHNMKALVKRLPAMVVVAALYGVNYDIHKAQLGVLGTPEGRRMERVYEHAPKYENEVEYLYSFVQIITACTASFAHGANDVGNAVGVWAAMYSAWSTSETVGSKAPVPLWQIAVIALTICFGFITYGYNIMRVMGNKLTYHSPSRGSSMEMGAAITILIFSQYKLPVSTSMCITGATVGVGLCNGTFKAVNWQRVGLLFFSWVMTIPIAGLIGGLTMGVLLNAPSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2022-12-14" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>M3D9F0</accession>
    <name>M3D9F0_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_115773</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762625.1">
        <property type="nucleotide sequence ID" value="XM_016901197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3D9F0"/>
    <dbReference type="GeneID" id="27898334"/>
    <dbReference type="HOGENOM" id="CLU_1807438_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF14504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="143" mass="15267" checksum="50CDEA352AFC3CD1" modified="2013-05-01" version="1">MHGAAIVKSVYTGLEQVVVAASCVDVQVSDAATPGQSRQSTAQVLRLLTGTHTPSELDELDGWNDVRATWPSSSWQIAQLSLTAGSHNMNMQTAAKSAASTTLSGRLPNRSTSTVSAVMHPLERNKGICLDNLREIFNTMVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M3DAD0</accession>
    <name>M3DAD0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_147031</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763171.1">
        <property type="nucleotide sequence ID" value="XM_016904043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DAD0"/>
    <dbReference type="STRING" id="692275.M3DAD0"/>
    <dbReference type="GeneID" id="27901180"/>
    <dbReference type="eggNOG" id="ENOG502SDJU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043321_1_0_1"/>
    <dbReference type="OMA" id="WFSNSID"/>
    <dbReference type="OrthoDB" id="2398441at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033768">
        <property type="term" value="C:SUMO-targeted ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038886">
        <property type="entry name" value="E3_SLX5/Rfp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28042">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE COMPLEX SLX5-SLX8 SUBUNIT SLX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28042:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE COMPLEX SLX5-SLX8 SUBUNIT SLX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="347"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="198"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="350"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF15050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="458" mass="49445" checksum="391A46B715FF832D" modified="2013-05-01" version="1">MDGAGGPGGSGGLPSFRRESVKRSFSTMAESHRDRDGSPATLFVPHDDHYNNEHPAQRARLASSRIALPQRYPGDGFDYRRPTMSGSGSGSSSGSGSNGNGQDRNPGVGVIDLTEEDDDLPRTRGTRGEEAGRDSRAQRGPRFGRNIIDLDGEDDAEDLTQPISHAAPSSAPRPNYLSLFPARAPTTTHPHPRYSGLRRPERSSPPRRTDMEDLTELRTRLHARPSESSRGHRSVTPYPNGRPEPIDLTGDEDELVIVDARTRAGINDERPSTTAGMGTRSVNDLFAHLGRPGRLFDRVMAFSGIPRTNANNVPARAQVTFVNPDAQQRGALQVNLDFGATAFDLGLGGNPPPPPKYEPPPSAAKGFTRSPGEQDVVVCPNCGNELAVNSDEKKAEVWIIKKCGHAYCGDCAQHRTKTTKGKGKAPVHSTPMPFKECVIHGCREKAGAKAMMHIFIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M3DAF1</accession>
    <name>M3DAF1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_147053</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763196.1">
        <property type="nucleotide sequence ID" value="XM_016904055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DAF1"/>
    <dbReference type="STRING" id="692275.M3DAF1"/>
    <dbReference type="GeneID" id="27901192"/>
    <dbReference type="eggNOG" id="KOG0721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014210_0_0_1"/>
    <dbReference type="OMA" id="RAILHAH"/>
    <dbReference type="OrthoDB" id="1734229at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031207">
        <property type="term" value="C:Sec62/Sec63 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000039">
        <property type="entry name" value="Protein translocation complex component (Npl1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24075">
        <property type="entry name" value="SEC63 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24075:SF0">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC63 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="11">
        <location>
            <begin position="107"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="641"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="668"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="688"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF15075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="707" mass="78608" checksum="2F26E86DEA2841F6" modified="2013-05-01" version="1">MSNEYNYDNDAQFFPFFVLTVTSLITVPLTYSLLRSPRDVSTLQNAGHIESDYKPVHADIITAQRAKQKRKEVRMKRIITAISGWVVMAYMVYLVMTTTREAATIWNPFDILDVPMSATEKVINSRYRRLSITMHPDKRHANPALNLTTEIINDEWVEITKAYKALTDEEIRNNWEQYGNPDGKQSTSFGIALPKLLVAEGSGKYVLAFYGLLLGIGLPWLVGRWWYGMQKVTREKILVTSAGNMFKEYRDRMDAGDVLAAVSTASEFDDILSGTKADAGLGKVESKLASTEASDAIMLPKDKTKLKEVEEPVRRKTLALLWAYLTRLDLDDATLEAEKYELAPTAERLNQAFVSMCLAYGLTAPVLASFHLSQSLVQAIPPSSAGKAPLLQLPHFTPSAIRDIETAANDKKEHMTIQSFMALPAEQRQALAQAAGITNDRLKVAEDVSRKLPYLKVETAFFKVAGEKYIIPSSLVQLVIKARFIPPGTPASSIPKVNPDDLLDVDAAEGDIQAAKKEPEQHNIPLAYAPYLARDRAPKWHVFLADNRQGKIAVPPFSFQTFDKKPFDDAGKPTFNVVTLKMQFGAPPQAGEYKFQMHMICDSYVGFDHKQELIMNIDDASRAEEVDDDDDISEPDEDTIAGQLAALKGDATAQDAPRKAKKIKPTEEDSDYESGTDDEEGASSGSETDTDTDSEAEDDNPKGKSWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>M3DBD1</accession>
    <name>M3DBD1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SEPMUDRAFT_154209</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 15">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 15">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763486.1">
        <property type="nucleotide sequence ID" value="XM_016907550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DBD1"/>
    <dbReference type="STRING" id="692275.M3DBD1"/>
    <dbReference type="GeneID" id="27904687"/>
    <dbReference type="eggNOG" id="KOG1376">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015718_1_1_1"/>
    <dbReference type="OMA" id="ESCYDIC"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000005">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000008">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="16">
        <location>
            <begin position="49"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="17">
        <location>
            <begin position="248"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EMF15365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="450" mass="50084" checksum="D7B0C60366A6986B" modified="2013-05-01" version="1">MREVISLNVGQAGCQIANSCWELYCLEHGIQPDGYLTEERKAADDDQGFSTFFSETGQGKYVPRTIYCDLEPNVVDEVRTGTYRSLFHPELMITGKEDASNNYARGHYTVGKELIDQVLDKVRHVADNCSGLQGFLVFHSFGGGTGSGFGALLMERLSVDYGKKCKLEFCVYPAPQVATSVVEPYNSILTTHTTLEHSDCSFMVDNEAIYDICRRNLGIERPNYENLNRLIAQVVSSITASLRFDGSLNVDLNEFQTNLVPYPRIHFPLVAYAPIVSAAKAAHEANSVQEISMSCFEPNSQMVKCDPRNGKYMATCLLYRGDVVPKDVHQAVATLKTKRTIQFVDWCPTGFKIGICYQPPQMVPNGDLAKVNRAVCMLSNTTAIAEAWSALSHKFDLMYSKRAFVHWYVGEGMEEGEFSEAREDLAALERDYEEVAADSAEGDEGAEAEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M3DBJ5</accession>
    <name>M3DBJ5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_147309</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763536.1">
        <property type="nucleotide sequence ID" value="XM_016904218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DBJ5"/>
    <dbReference type="STRING" id="692275.M3DBJ5"/>
    <dbReference type="GeneID" id="27901355"/>
    <dbReference type="eggNOG" id="KOG1256">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_45_4_1"/>
    <dbReference type="OMA" id="IWHSYER"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031957">
        <property type="term" value="F:very long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015916">
        <property type="term" value="P:fatty-acyl-CoA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF33">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="64"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF15415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="704" mass="77766" checksum="29F7B1DF60CA69DE" modified="2013-05-01" version="1">MGSQIAINKAAELVQPPPVGAPYSVAVPGSKVEGRSAVYRHWRQKDGVLHTLDPEITTAHEFFEQSAKRVPNNLCLGRRPYDAVKKAWGPYVWETYAQIQERRKNFGVGLVALHEQVGVTGRQYGVGLWCQNRPEWQITDLACMSQSLFSVSLYDTLGPDACEFIINHAQLTAVCSSVSHIAMLLRLAPRCPTLKLIVSLDPLSAEGELPGTSKKDILSALAAQHGVQVHDMRDVEAMGEKSPRPFHPPRPEDTVTINYTSGTTGNPKGVILTHKNAVAAASASLCISRSMKGDTVCSYLPLAHIFQRVTEHSILWAGAAIGYFHGNILELVDDFKLLRPTTFTSVPRLYNRFGGAIKAATVEAPGFRGTMSRHIVEKKLNSLTQQPAGKATNTHFLYDRIWARKVSAALGLDRAKTMISGSAPIDPGLQQFLRVVFANNFFQGYGLTETYAIGTAQLEGDMSAGNCGAVATATELCLLDVADMDYLSTDKPNPRGELLIRGPTVFKEYFKNEEETKKAFTEDGWFKTGDICEIDEMGRFKIIDRRKNVLKLQQGEYISPERIENVYLGNLPFLGQAYVHGDSTQSNVVAIFGIQPDLFAPWVEKVLGKKMNPTDLPALEAAAGEKKVQKAALRELAKVGKKAKFNSYENVKSVRLLLDPFSIENELLTPTLKLKRPQTAKKYRQLIDEMYAEIEAEATPRSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M3DCA0</accession>
    <name>M3DCA0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">60S ribosomal subunit assembly/export protein LOC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_37974</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for efficient assembly and nuclear export of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the 66S pre-ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LOC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763555.1">
        <property type="nucleotide sequence ID" value="XM_016908691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DCA0"/>
    <dbReference type="STRING" id="692275.M3DCA0"/>
    <dbReference type="GeneID" id="27905828"/>
    <dbReference type="eggNOG" id="ENOG502RY6R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096593_0_0_1"/>
    <dbReference type="OMA" id="NAEQEGH"/>
    <dbReference type="OrthoDB" id="1743802at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008298">
        <property type="term" value="P:intracellular mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037650">
        <property type="entry name" value="Loc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28028">
        <property type="entry name" value="60S RIBOSOMAL SUBUNIT ASSEMBLY/EXPORT PROTEIN LOC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28028:SF1">
        <property type="entry name" value="60S RIBOSOMAL SUBUNIT ASSEMBLY_EXPORT PROTEIN LOC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="137"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="175"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF15434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="198" mass="21791" checksum="BA7363FFD448A888" modified="2013-05-01" version="1">MAPKQNRVTRPSSGPKRTPSKSSSASGPPTKSKKPGKKAPPVKTNKAVKQGTAKSKLPPHKRYTESELKVPQLNGIIPAGVSKPPNQKKGKVFVDDKESMNVIMAMVMAEKEGNLESKMMKTRQLEEVRAAKLAEAEKRVAGKKSEMEDRKANIKTEGKKSKRRRSDRDGDGEDGDRSNKKVDDGSKKVKLRKRVSFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M3DE13</accession>
    <name>M3DE13_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">U6 snRNA-associated Sm-like protein LSm7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_147697</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764106.1">
        <property type="nucleotide sequence ID" value="XM_016904469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DE13"/>
    <dbReference type="STRING" id="692275.M3DE13"/>
    <dbReference type="GeneID" id="27901606"/>
    <dbReference type="eggNOG" id="KOG1781">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076902_3_0_1"/>
    <dbReference type="OMA" id="PFVQQEE"/>
    <dbReference type="OrthoDB" id="274944at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008266">
        <property type="term" value="F:poly(U) RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01729">
        <property type="entry name" value="LSm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000043">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017132">
        <property type="entry name" value="Lsm7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044641">
        <property type="entry name" value="Lsm7/SmG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553:SF5">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM7"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
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            <end position="119"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF15985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="134" mass="14227" checksum="D31FC5A2FB3BC1B9" modified="2013-05-01" version="1">MAERGQFRGGGRGRGEGRGRGGGGGDRGGRGGGHAPNSERKKENILDLSKYLEKGITVKFNGGREVTGTLKGFDQLMNLVLDNVKETTRDEEGNTSTRNLGLLVARGTLLVLISPVDGSEEIANPFVQADVDDE</sequence>
</entry>
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    <accession>M3DE25</accession>
    <name>M3DE25_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_124141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
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            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="OMA" id="GHNAKAD"/>
    <dbReference type="OrthoDB" id="410198at2759"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR020100">
        <property type="entry name" value="Glc-repressible_Grg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38789:SF1">
        <property type="entry name" value="GLUCOSE-REPRESSIBLE GENE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38789">
        <property type="entry name" value="REPRESSIBLE PROTEIN GRG1, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14210)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11034">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="33"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF16005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="88" mass="8850" checksum="8E37B6DAB54D59FE" modified="2013-05-01" version="1">MSAPNANAPNEGIVGQIANSVSNAANYVAETVQGKTAEASKEANKEQAKGNTPNSSIGDRVSGATGAISDKLDQTKHEGAASANKHSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>M3DEB3</accession>
    <name>M3DEB3_SPHMS</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_115178</name>
    </gene>
    <organism evidence="1 2">
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016901137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DEB3"/>
    <dbReference type="GeneID" id="27898274"/>
    <dbReference type="HOGENOM" id="CLU_2428455_0_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF16130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="91" mass="10054" checksum="3FD45FBEA1677EC5" modified="2013-05-01" version="1">MGRYEQKHSSIPISASAGLQSVIYDNSTPGASRDPSMVWLIDVVVIIPDFEKFSSETVNEIKKFWQPRFESGIDLACPMLLSRAELPLGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M3DF02</accession>
    <name>M3DF02_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_106266</name>
    </gene>
    <organism evidence="3 4">
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        <name type="common">Poplar stem canker fungus</name>
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        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
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            <authorList>
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                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF16104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016900624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3DF02"/>
    <dbReference type="GeneID" id="27897761"/>
    <dbReference type="HOGENOM" id="CLU_1526104_0_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF16104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="176" mass="19500" checksum="93E55E557BDE5848" modified="2013-05-01" version="1">MSQSNSQAMAESSSQPKARIPLDAPGGFSRLILSGMTDSLEGVRNFDDALARIEALSDMEEVVKAAGQLFRVFVDLCNNLDRYIEICRRGDHEALLEVRSIIYVLVTAFLALLALSWMPSFALHTQTLAIGSEELSEDKVSADEANKERGHFVGPRIPRRSQRDTRFERVGTTLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1QDD2</accession>
    <name>N1QDD2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acyltransferase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_166069</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757462.1">
        <property type="nucleotide sequence ID" value="XM_016908199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QDD2"/>
    <dbReference type="STRING" id="692275.N1QDD2"/>
    <dbReference type="GeneID" id="27905336"/>
    <dbReference type="eggNOG" id="ENOG502SHP9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005679_13_3_1"/>
    <dbReference type="OMA" id="GPDEENH"/>
    <dbReference type="OrthoDB" id="5405781at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050879">
        <property type="entry name" value="Acyltransferase_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028:SF125">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="2">
        <location>
            <begin position="14"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF09341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="444" mass="50749" checksum="05E1D133D4F3780E" modified="2013-06-26" version="1">MTPPLEPDKKKNTVYLDGLRGLAALLVYFYHHVSWYFGPTDDIINGWGANGNHYFFQLPFIRLLLTGGNAGVVIFFVLSGYVLSLSPLRQLRDGHVQQTYRALISSVIRRPIRLYLPVIGVSGAFVIGLHLPLGLAPQLAWPAPKETLWLEMKSWMYEVLIALQPSTKPDVLAHWFIYDPPVYTIPVELVGSCLIFSAVAISGHVSMRMRAVVYGLMYVALLLMYQWAMACFMAGILLAMNDLKEPVPTARMQLSARAKKTLHHIAFFSGWYLLCQTAGMRDTQVSSDTPGWWLLTQLIPPIYYDDPDKEYWRWWHVWGAFLVVYGVLRITWLQRFFASRPLKYLGKISFALYLVHGPIMWTLGDRIYRFFGHITMPEMTTMWDERFPIPEFGIHGFTTRFLVAQAFILPLNIACGHVGTVVFDAPSVRLGRWVVGRLGLDQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1QEL2</accession>
    <name>N1QEL2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PhoD-like phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_150815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758971.1">
        <property type="nucleotide sequence ID" value="XM_016906414.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.N1QEL2"/>
    <dbReference type="GeneID" id="27903551"/>
    <dbReference type="eggNOG" id="ENOG502QPI0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000998_2_1_1"/>
    <dbReference type="OMA" id="FCVIREY"/>
    <dbReference type="OrthoDB" id="9999821at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043904">
        <property type="entry name" value="PhoD_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689:SF1">
        <property type="entry name" value="PHOD-LIKE PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19050">
        <property type="entry name" value="PhoD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoD-like phosphatase" evidence="2">
        <location>
            <begin position="831"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD-like phosphatase" evidence="2">
        <location>
            <begin position="1093"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="560"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1252"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1312"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1497"/>
            <end position="1539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1554"/>
            <end position="1579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1592"/>
            <end position="1731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="309"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="359"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1322"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1346"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1522"/>
            <end position="1535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1611"/>
            <end position="1621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1710"/>
            <end position="1723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF10850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1731" mass="190719" checksum="63A8D0C7ABAD29D2" modified="2013-06-26" version="1">MSEHQRRQSGLWSRNPATGFFEQISAAPKAQIGPGFYANPHVTTGPYTYYQPQAGGGGGGDGKRSFSDRTGLQTGSNGTSRADSRRKERSNTLESKKPLRVVNPDTDFQTTFPQPAAQPALSLDPDYVPTNVRSMPWSPDAMSPGTANVPQPAAAQPSKQRQASTASNISERVRRGSVPDRSPLQHLETWSKEEKRARVAHAEERARQKSIAGGRTDPEGERSGTVRGERSRVGSDGASRRPTQTEKIRTVSSPDAQAEAGARRFRDARDSLMRENMSPTSPTAGSAAPIANQSKVYDRAPERRPQPIAPAAPAAPAAPIAPAAPIASAAPAAQDAQPVTNKKGSVEIARSDSRKYRAKNAGFAGAEAAAWSGPSIPSAGYSPGAAERGKVAYDKRQSHIQSEATSSPISPLSQDSGSNVARSNSKKLQKRFAGGQTDEYSARNALHSDRMGGISGSKKERKAAEAHIPPDPVPRASVENSRPEDGVRYAIPPQTANAQHAREQVAFSAPANFHDHQDKQHHGVRGFFHRGHEPRRGYQPSIPLEDWRNAKPAVLTADDIDFGPARTSPENGDAAWWEKNGKRSSSSGSKQVPDMAQFDGPYEEKANGFQPRLFLKCGPLLRYTGIRRQTIRNQRTNAVSQREVWKGTVMIVTEDDQSDLERKPTIRIFAQPMDLHTPPPQHLVDSGRELPPEYEDPVAGQTKLSRTGRALYVRPVHDIEGGTDLSREENNQGLFSAQRTPVLGPQATIGVDGRPTQHITFQDKSRVKRRDGERAGRYRETKAVRLHSERGYTFWRFSIEIELGNRQSRIAYRINRGPAIGFWVPARGDAMNIMFHSCNGFSLSVDSNKFSGPDPLWRDVLNRHQARPFHVMLGGGDQIYNDAAMRDTELFREWLQTKNPQHKHEADFTVEMQEELEEFYLHRYSMWFSQGLFSMANSQIPMVNIWDDHDIIDGYGSYPHHFMSTRVFTGLGAIAFKYYMLFQHQSVAGETELEEPSWLLGKSPGPYINERSRNLFMSLGRHIAFLGLDCRTERMRDEILSQETYDAVFDRCRTEIVQGETKHLVVLLGVPIAYPRLNFLENILTSRVMDPIKAVGRTGMLGGFVNKFDGGVEILDDLDDHWTAKHHKAERNWFIQELQELAAEKSVRITILGGDVHLGAVGQFFSNRKLGLSKDKDHRYIPNIISSAIVNTPPPTMMADVLNKRNKIHHLDADTDEDMIPMFSHDVDGSKRNNNHLLPRRNFCVIREYIPGSTPPPTPRKEAGALASGPPQFDGAGDEYRQDAKNAQKYPPGSMKRTMSLTRGPAALVRRLSGSSKRGPPQISQPLEQTRPYNHNDKRPGGMQRSASLSAAATGGSYFPDQERYYSDAAPERPSFQRRPTNLSEKQPRRFSFVGKKGSNGLDGAADDSDDSFGHVNLEGGLDISLCMEVDQHNPAGTTVPYRLLVPALWYAGDGDQNTAKFETHRKSLMERLRLNRNREAPSGTDDTVAGAVAAPRESAEYSDYRGTTDGTRTPSPDYRTQRNTALNSNPNAGVTSPAVGMGLTDTGRGAYGARSRSASYGNAGHVVNHTPRVSSGHMRNGSDAYQKGYHFQGPPIGPSQQQYAKPAAAANNTYPQSGYRRTNAPAPASIPAAQGNRGPYGRSPPNVQRGHGAYDGHQDAYDSEGSLTGSEDFEDEHMGRQPLPPQRRGSKAERFFGIGAGRASMDQGRPGEGELGRSESKGKAGWKIWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1QES8</accession>
    <name>N1QES8_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_92250</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757633.1">
        <property type="nucleotide sequence ID" value="XM_016910583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QES8"/>
    <dbReference type="STRING" id="692275.N1QES8"/>
    <dbReference type="ESTHER" id="sphms-n1qes8">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="GeneID" id="27907720"/>
    <dbReference type="eggNOG" id="KOG4389">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006586_10_3_1"/>
    <dbReference type="OMA" id="SIAHHIM"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000263">
        <property type="entry name" value="Carboxylic ester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="62"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF09512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="615" mass="68077" checksum="B8ECFBB135C3118A" modified="2013-06-26" version="1">MEKVDDSPPARRALGARSRGLGIRFLAAPLLAFLLLYNVVPSVHDSVQSFFSLHGWNIEQLPLADTAQGTFVGKVLDNNAHPIPVEAWLGIPYALPPVGDLRFAKPVPVPDSNETIQATEYSLRCPGKQLLRIPGTPWLEASEDCLTLNVFRWRGTFANAKLPVLVYIHGGAFNRGFAAMHDTASMLANSEEPFIALSFNYRIGALGFLNSPLTEKEGLLNLGLHDQKLLLEWVQKNIESFGGNANDVTIAGLSAGAHSIGHHIMDINEKRELFHKAIIESGAATSRAVHPAHSQLHREQFEKFVAEAGCNGKAESEVLPCLREVSTEVIQTAQTAVFDEYNPSVRWAWQPVLDNDIISRRPLDAWKSGHWHRVPIITGFNHNEGTMYVPKQTESSEDFTNFFATLLPQLTPKDLSRLNDLYPDPSSDILSPYFDTRNLTALGIGAQYKRVEAAYGHYAYVCPVRQTSHFASISSISSAGSAAPPIYQYHWAVNRTILGGANHGDQMWYETLSPLVREISPTQEEIAKIFNSYLTSFVVTGDPMTLRGRKAVQRPVWKAWNGDDDVGGKSTMIFGKDNDEAAGGSNVGVAAQVVVDEWAEEECRFWWEKSEVPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2023-02-22" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>N1QF03</accession>
    <name>N1QF03_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_117706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759853.1">
        <property type="nucleotide sequence ID" value="XM_016901365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QF03"/>
    <dbReference type="GeneID" id="27898502"/>
    <dbReference type="HOGENOM" id="CLU_1866382_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110748" evidence="1">
        <location>
            <begin position="20"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF11732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="137" mass="15736" checksum="1E30357C68074A8C" modified="2013-06-26" version="1">MKATILVAAFMACWTNVYAEDCPPCTKFDPSAPNSPCGEMQFGGVGCQCWELGRDKHTYRLFAHKDGTKVEIDENNRIHMWCNDKACIRKDYCKIEPYWRDLADWVHDGSYELPAGNGCCQLPAHYIQHATMYKMPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1QF26</accession>
    <name>N1QF26_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Glycoside hydrolase family 28 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SEPMUDRAFT_149684</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759934.1">
        <property type="nucleotide sequence ID" value="XM_016905706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QF26"/>
    <dbReference type="STRING" id="692275.N1QF26"/>
    <dbReference type="GeneID" id="27902843"/>
    <dbReference type="eggNOG" id="ENOG502R2FT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016031_7_2_1"/>
    <dbReference type="OMA" id="NMMLIKS"/>
    <dbReference type="OrthoDB" id="2268901at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046576">
        <property type="term" value="F:rhamnogalacturonan alpha-L-rhamnopyranosyl-(1-&gt;4)-alpha-D-galactopyranosyluronide lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF19">
        <property type="entry name" value="PECTIN LYASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110752" evidence="11">
        <location>
            <begin position="18"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EMF11813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="451" mass="47921" checksum="EFEBF77BFD510AAC" modified="2013-06-26" version="1">MHALLTPLLTIAALVVAQSVELSGSVGPLTTIADKKAVATCDITDYGAVADGKTDISDALNQAFEACKAGGVVVVPSGDFALSTWVKLNGGSAWAFQLDGTIYRTGTEDGNMIFIEHTDDFEMFSSNGAGAVQGYGYEFHKDGKDGARILRFYDITNFSIHDIILVDAPAFHFVMDTCDRGEVYNMLIRGGDKGGLDGIDVWSTNIWLHDIMVTNKDECVTVKSPSKNILVESIYCNWSGGCAMGSLGSGVDVSDITYRNIYTYKSNQQFMIKSNGGDGTASNIVLENFIGRSNAYSLNIDQYWKSMDPISGDGVQLSNISISNWTGTAADGTERGPIKLMCADGAPCTGIDITDFAMWTESGDSQTYSCRSAYTSNDPAPFCLKAGAAGDAPPYSATTLTATSAPTGYQAPTMPDDLADSFGTTAMIPIPAWPANFFPGIPPMRALAASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1QF31</accession>
    <name>N1QF31_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cation_efflux-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_149661</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759893.1">
        <property type="nucleotide sequence ID" value="XM_016905695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QF31"/>
    <dbReference type="STRING" id="692275.N1QF31"/>
    <dbReference type="GeneID" id="27902832"/>
    <dbReference type="eggNOG" id="KOG1485">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013430_10_1_1"/>
    <dbReference type="OMA" id="KKPIREY"/>
    <dbReference type="OrthoDB" id="78296at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098771">
        <property type="term" value="P:inorganic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1350:FF:000004">
        <property type="entry name" value="Cation diffusion facilitator 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000005">
        <property type="entry name" value="Putative Cation diffusion facilitator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF4">
        <property type="entry name" value="CDF DIVALENT METAL CATION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="333"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="444"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="482"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="8">
        <location>
            <begin position="338"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="249"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="282"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF11772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="624" mass="69372" checksum="E3799CFC1063FB49" modified="2013-06-26" version="1">MCAHVSLPGEDHRLARTQSLNADNRSPAQHRNFLPLINHSDALHTSADGGASPYSTRGSHLPSLIQSRSSVNVNALRKGPWIARNNSISAAELATMRQRKDSEGSLDGLEIGHSSAAGWGGGDNEDRRMSYAASILNTPQVRSQRLIGSTNPRYQWEQYWKTDEQLKQIKSKATRKYYERNNYLIQHYLYIDRLLDSSLPHDLIQEYHSPHVRSAIKQGSWQKDLPETIDESVDEENGLPSHIYHERAGSQDSLFADDDAVPDSLRPPQKINRTKDLYNVKKPNNSAVSNRSPSQNHSEGETEPLLSSDSDLEAQEMPPDLELDEDHSSQSSIVTVAIIVNLIANTALLVMKVIVVVLSSSVSVLASLVDAALDFLSTAIVGITTRLISRTDQYAYPIGRRRLEPVGVLVFSVIMITAFIQVMWEALSSLTNGDHEPVQLSNSAIAIMAATVAIKGGCWAWCRVIKNSSVQALAQDAKTDVVFNTFSIIFPLVGYYANIWWLDPVGGIALSLYVIINWSRTANEHIRNLTGASASADERNILLYLTMRFAKTIQKIQGLQAYHSGDKLNVEVDIVLDEEISLRDSHDLGESLQYVLESVPSVDRAFVHMDYADYNIPTHMFQES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFC1</accession>
    <name>N1QFC1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_26035</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760013.1">
        <property type="nucleotide sequence ID" value="XM_016908404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QFC1"/>
    <dbReference type="STRING" id="692275.N1QFC1"/>
    <dbReference type="GeneID" id="27905541"/>
    <dbReference type="eggNOG" id="KOG3425">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120161_2_0_1"/>
    <dbReference type="OMA" id="RTQWNIH"/>
    <dbReference type="OrthoDB" id="78947at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047134">
        <property type="term" value="F:protein-disulfide reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045108">
        <property type="entry name" value="TXNDC17-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010357">
        <property type="entry name" value="TXNDC17_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12452">
        <property type="entry name" value="42-9-9 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12452:SF0">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06110">
        <property type="entry name" value="TXD17-like_Trx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="23"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF11892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="158" mass="17728" checksum="EBD9E7259BDAD7E7" modified="2013-06-26" version="1" fragment="single">MTILKSFPLPSSPSALQIPNEKEKDSPPSNFFIAFLASKDPLTNQPWCPDVRAALPILEATFQETTTSQGAEGEEEKEEGKKSTTTPPVVAFIEVGQKTEWKNPHNVFRTQWNIHNVPVLVRYELVGENTATTTKQVKEVGRLVEGEILDERRLQELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFS2</accession>
    <name>N1QFS2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Carboxypeptidase S</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SEPMUDRAFT_150646</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758718.1">
        <property type="nucleotide sequence ID" value="XM_016906309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QFS2"/>
    <dbReference type="STRING" id="692275.N1QFS2"/>
    <dbReference type="GeneID" id="27903446"/>
    <dbReference type="eggNOG" id="KOG2275">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021802_11_0_1"/>
    <dbReference type="OMA" id="TIDSWTH"/>
    <dbReference type="OrthoDB" id="3064516at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000328">
        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05674">
        <property type="entry name" value="M20_yscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000098">
        <property type="entry name" value="Gly-Xaa carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017141">
        <property type="entry name" value="Pept_M20_carboxypep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047177">
        <property type="entry name" value="Pept_M20A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE/HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962:SF1">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE_HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037217">
        <property type="entry name" value="Carboxypeptidase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="9 15" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="16">
        <location>
            <begin position="289"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="active site" evidence="14">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="552"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR037217-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR037217-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMF10597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="585" mass="64316" checksum="C1DB185ADDC56EE9" modified="2013-06-26" version="1">MEKSSLPIAVEQRAPASAGTRQRALRAILVSLTISIVCLNWLYGPLTSILGRDHLDHDEQSSGPSCGQVPALWPPSNDKLQDAYDFLFTDQFENASIARLSGAVQIKTESFDDLGEIGEDKRWDVFVPFHEYLAATFPRIHSELKVEKVNTHGLLYTWQGSDADKKPIVLMAHQDVVPVDGDTVDSWTHPPFSGHYDGQLIWGRGSSDCKNQLIGILETLEYLLQAEYQPKRTIVLSFGFDEECSGHQGAGHLASFLLERYGKDGVAAIVDEGMGYQEAFGTGFAVPGVAEKGYTDVDIAVRTPGGHSSVPKDHTSIGILSEIITIIESQQYPTYLADKNPYLEFLQCGAEYAPDFPKKLKKLLKSRSASSDLPTCAKKHHDQLAIEAAKAGASTKYLMQTSQAVDLIHGGTKTNAMPETAVATVNHRINIGDEPETVWAHLAHILKPVAEKYNLTLHAFDGEDAAYNSISLSSKKTSLKTAPVTPTSIDVVSPYAVISGTIRALYGEDTMVAPALMTGNTDTRYYWDLTKHIFRFGPGYVKEEDSSLGKIHTVDESVAVSNHFKVVRWFTLFLRNIDEAQLAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFV3</accession>
    <name>N1QFV3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_120263</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757529.1">
        <property type="nucleotide sequence ID" value="XM_016901585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QFV3"/>
    <dbReference type="STRING" id="692275.N1QFV3"/>
    <dbReference type="GeneID" id="27898722"/>
    <dbReference type="HOGENOM" id="CLU_524933_0_0_1"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF09408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="519" mass="58270" checksum="A9E3F59826FEEFC6" modified="2013-06-26" version="1">MTDVVLMIERNTGVVKALYESDTTLLRGLNPEAKERDDLHMVMHECHCVLEEDPVKFREVRPDFLATGLAVIGVERPETMGALDPSVGGELIKAVVQANQDVDSVQPTSVDSARWQRPMFSIAGGGLSESPVERASFVELMLRATVCLLLFLLSSLHPLLPILSTAHYHNAGNTFTPHLTALVPAHNMGHVHSTEEIAAATVPRRDDELPKASDVSKENDELLSRMSQQLRQFHASCRTSRSNLMSSVARSSPAFNHSAVQNPPPATVVASPPPASFESLRPASFVAPPPQTHARPLLAVIQQPVPPHYPGSKFVKFMRLRPNIRIHTTASIEVFNRVPESYRTGQHIAEWILQKLDMKTLLLAQRVCTTFRGLVRYQIRLQRQLWFIDTNGATRADLLEDPDYVDPLIGRLRQDLDLFFDYDPRRPRQKILYMPVPPQAKFDHSPVSNWRKMLVMRTAKRYLRWEIVIPGVAIIDLGKMERAPTFGLVTAVIINAMHYGGRGIAMIIERDRLGRMLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1QFX6</accession>
    <name>N1QFX6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Vps53_N-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_89958</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VPS53 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758783.1">
        <property type="nucleotide sequence ID" value="XM_016910514.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QFX6"/>
    <dbReference type="STRING" id="692275.N1QFX6"/>
    <dbReference type="GeneID" id="27907651"/>
    <dbReference type="eggNOG" id="KOG2180">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007339_1_0_1"/>
    <dbReference type="OMA" id="YKFAEAK"/>
    <dbReference type="OrthoDB" id="10261632at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.110">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 53, C-terminus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039766">
        <property type="entry name" value="Vps53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031745">
        <property type="entry name" value="Vps53_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038260">
        <property type="entry name" value="Vps53_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007234">
        <property type="entry name" value="Vps53_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 53 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16854">
        <property type="entry name" value="VPS53_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04100">
        <property type="entry name" value="Vps53_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps53 N-terminal" evidence="8">
        <location>
            <begin position="18"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Vps53 C-terminal" evidence="9">
        <location>
            <begin position="615"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="788"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="800"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="853"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF10662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="853" mass="95208" checksum="1DFC8199C2646E0E" modified="2013-06-26" version="1" fragment="single">MAVINGGSVPADALDADEYNPIDHLNALFSHPSTLSSLSDVSSQLQTYQTSLDTSIATRSRLAAQTTSDSVRRIQDAKCELAALFAKIDGVRERALETERTITDMTADIKRLDSTKRNLTLSMTALKRLQMLTTAYEQLRGLAETRQYRECAHLLQAVIQLMAHFKSYRSIDQIATLSKNVSEVQRELLEQVCEDFEVTFARGEVQQKRSMLNEACQVMSALGDNARARLVTWYCNTQLREYRQVFRGNDEAGSLDNIARRYSWFNRMLKTYDAEHAALFPREWKVNEMLANAYCENTRDDYKDILKKSMRRADGQPPDVNLLLSCLQETLDFEHSLEKRFSSGESRSSMDTVTSGLDGDRRPGFSQAISEAFEPYLSVWVESQDKQLASLIPKYRQQQIRPPEEEFHAQLVIPSSTELFHHYRVTLAQCAKLSTGARLAELSATFGKYLDQYAQQVLLFFFSEKTGGPSVEDAVIILNTADYCYTTTNQLEEKIKSRIDEELRDKVDLQAQADTFMGVASAAVRALVHKAEIDCEPAWREMRSIPWGKMDSVGDQSSYISSLLSRLRDCSKDILRYLHKPQYARAYCDNLVDALTTTYITNIVACRPVSETGSEQMLLDTYVFKKGLAELATLNADTGTPINQAFVKRVNQSTAKLDPILKTLQVRTSPPEGLVQAYLIHIRDRSEANFRKMLELKGITRKQEQSHLVELFNAHKASPANDSLQPSNPLITALQLTNQSAPTSAGLNLASLKDNAIANSTPSLPARFDPSNFGSALMNAARDAGDRFSSPNAAIHRDGTTSTSIGSRTTSPPGGLGRTSMDADSTATTLNENLRNIGRFFKKDGAGFSGFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1QG86</accession>
    <name>N1QG86_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_70339</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758958.1">
        <property type="nucleotide sequence ID" value="XM_016909902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QG86"/>
    <dbReference type="STRING" id="692275.N1QG86"/>
    <dbReference type="GeneID" id="27907039"/>
    <dbReference type="eggNOG" id="ENOG502S0CB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085801_0_0_1"/>
    <dbReference type="OMA" id="IKFSRQN"/>
    <dbReference type="OrthoDB" id="37297at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33875:SF2">
        <property type="entry name" value="ACR183CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33875">
        <property type="entry name" value="OS09G0542200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF10837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="208" mass="23395" checksum="CEBEA9AFCD156831" modified="2013-06-26" version="1">MALAPKFAGQKFAATSSPATLHTLELFLDYVCPFSKKQFDTVYAEVFPILKSQYPDKLQVIFRQQIQPWHPSSTLVHEAGVAVLQTNPDKFWDFSKALFAKQTEYFDANVVNETRNDTYKRLAKLAASVGLNEKDIYSRLEISDKPDKDGGLNGGNAVTNDIKLLVKAQRLQGVHVTPTVMFNGYPDNSISSSFTKDDWEKWLAKNVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1QGG2</accession>
    <name>N1QGG2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">V-type proton ATPase subunit D</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">V-type proton ATPase subunit d</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10 11">Vacuolar proton pump subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SEPMUDRAFT_151574</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SO2202</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Vacuole membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase D subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757739.1">
        <property type="nucleotide sequence ID" value="XM_016906901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QGG2"/>
    <dbReference type="STRING" id="692275.N1QGG2"/>
    <dbReference type="GeneID" id="27904038"/>
    <dbReference type="eggNOG" id="KOG1647">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069688_0_1_1"/>
    <dbReference type="OMA" id="REEFFRM"/>
    <dbReference type="OrthoDB" id="7676488at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3240:FF:000002">
        <property type="entry name" value="Vacuolar atp synthase subunit d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002699">
        <property type="entry name" value="V_ATPase_D"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00309">
        <property type="entry name" value="V_ATPase_subD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11671">
        <property type="entry name" value="V-TYPE ATP SYNTHASE SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01813">
        <property type="entry name" value="ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="231"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EMF09618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="262" mass="29743" checksum="E92A6ECE890663D3" modified="2013-06-26" version="1">MSSGAGREAVFPTRQSLGLMKSKLKGAQTGHDLLKRKSEALTKRFRDITRRIDEAKRKMGRVMQIAAFSMAEVTYAVGNSGFGYQILEGARTARFRVRTKQENVSGVFLPQFESFQEEGVKEEYAMTGLGKGGQQVQKCRETYTRAVETLVELASLQTAFVVLDEVIKVVNRRVNAIEHVIIPRTENTIKYINSELDEMDREEFFRLKKVKGLKERAAAADDEQRKIRALKEKAEGKENATEQEQQEAKDILGEEKDEDLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1QH04</accession>
    <name>N1QH04_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_150541</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758554.1">
        <property type="nucleotide sequence ID" value="XM_016906247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QH04"/>
    <dbReference type="STRING" id="692275.N1QH04"/>
    <dbReference type="GeneID" id="27903384"/>
    <dbReference type="eggNOG" id="ENOG502QS34">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046574_1_0_1"/>
    <dbReference type="OMA" id="VFPMTWK"/>
    <dbReference type="OrthoDB" id="93019at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051178">
        <property type="entry name" value="TfdA_dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43779:SF2">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT XANTHINE DIOXYGENASE XAN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43779">
        <property type="entry name" value="DIOXYGENASE RV0097-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="18"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF10433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="373" mass="41795" checksum="5DCB64078BB8DC8B" modified="2013-06-26" version="1">MAITSKITVHKITPPAGAKYDIGAEIRGADLDNLTPVDFDVIRKALYENQVVLFKNQQDLSPRAQYELTQLFDPEAQSYGHGKTIDAKRSILHPDLKTIPHQPQVQVIGNGPVAEFQGLKNITLKHPHHKTFHKDVISPEDDRDNTRFYRWHIDAALYDLNAPRVTSLMAVSVPKTEQQTLRYDDGTGDKLSVPRGSTVFASSYTMYDLLSEEDKEFVRTTKVQYAPHPYVWMSPAKSKSDGLGLVSEGLELSPSQLPEIDESKIKILPMCWRNPVTGKLALQVHPSAVQKLHLKDGTVMDDLEQVRETVHRLQRPGIAPELIYAVDWEAGDLALFNNHGVLHSVTGSFLPEEVRIFRQCNLAASEEPLGPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>N1QH98</accession>
    <name>N1QH98_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_92042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757515.1">
        <property type="nucleotide sequence ID" value="XM_016910577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QH98"/>
    <dbReference type="GeneID" id="27907714"/>
    <dbReference type="eggNOG" id="ENOG502S7KY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_358267_0_0_1"/>
    <dbReference type="OMA" id="PAEEWMG"/>
    <dbReference type="OrthoDB" id="2504266at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046784">
        <property type="entry name" value="Eap1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20566">
        <property type="entry name" value="Eap1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="733"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="608"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="654"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="681"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="755"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF09394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="800" mass="88030" checksum="193FA229F1F1235E" modified="2013-06-26" version="1" fragment="single">MAVRRYTRDELLALSRSTLVSRPDDLPAIEQWIDEQPQAANHERHKSNDGALGKSRQPRAGLAGAAAAEGSPMGAFSTGRPTLSSRGSMLRNASGDDVSLGPPRNMFPSSRTLSKAADQQDRNAGDTTPHDDPESMRSRFFSDRQSNRKSAMEKEGIENKDRWSSVRDRRLQGELEEDKKTFTRQDRDNEADRRNGYGHKEDPRWSRDDRTNGNKAAGGGWRDREAARRDRDHQEREPEWMDDPVVKKDQELGLTVRTQDDFEEWKRQMSGKPKAEHVLASEPVPLPAAEQPKPGLKLDVFEGGFFGGFKNVTSATAPGASAPLMAAASAGVKPLGKGKTSRFASMFKPPEAESIPTPALAEESQPQATNGASSKTAEDQEGFNRVLAMLGGTKVSNGPPMPEPARDLAPSYAEPVPTSPPPPPKSMTSSGTLPGGRKSRFTDMFAQEKNPERMQSTQSGSPPLQGDGSLEGSRRSPPEDNGLYVKQRLPARPPSHQNISRPQGPESAMSPDPSGIPFNALREQQPRPSSGRPNDHYNRFEPPLRGAASPDRNIQDLLAQPRHRPQPTSSQSQDLLNLLKNPASRPQSQQALPVNGGIDQADLERWLQHQQPTQSHAPTQTLAPKPRGPQQPPGGFEEQLMRNYGQEQQRHEQMSQLQDRQQTRAPPGFYNHEQQDAMFAQQQRHMNQRQQMQQQQQQQQQPPRRMSGHPVLQQMHIPPQHSQPDFHQLTSPIGGGAPPPPGFNQMPRFPPGFANVSNFPPQQREQPPPGFNGGPMSPPALSGGAPPGFFGGPPSLPPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1QHB5</accession>
    <name>N1QHB5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_72114</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456269">
        <property type="protein sequence ID" value="EMF09419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016757540.1">
        <property type="nucleotide sequence ID" value="XM_016909971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QHB5"/>
    <dbReference type="STRING" id="692275.N1QHB5"/>
    <dbReference type="GeneID" id="27907108"/>
    <dbReference type="eggNOG" id="ENOG502SMA3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019101_0_2_1"/>
    <dbReference type="OMA" id="WCQRETT"/>
    <dbReference type="OrthoDB" id="4329349at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="38"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF09419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="351" mass="38815" checksum="8C8D349DC29C3013" modified="2013-06-26" version="1">MTCPSTQYHNDSTYVPEMWTWFSIGTLVTILRLAVTFRQVGCGKWQGDDILALVVWMCFACKSIALTMVFKYGTNMDYYSAEAVAILGSCQLDQVVTGSKMELVAWYAYCSIIWGLKGMVLFILARFRLVCDRIWLFRTAAVMTGVSYAAMFLALCLGCLPYRENWQVDPPPPSTCSFRMHDVYVSAILNVTTDLLILAIPLPILWKIRVGLGKKIGLILLLCSGIFVMAAALIRFGFVQTGSTSSNLNKWCQRETTIGIIVVNMPILWTWIKPLFISRASMLPARGCHPLSVVNMPCQETPPLYKCGLLPSTSDAPKLPHGTGASLDRGVTTPAAKPHILSTVHPLDASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1QHM3</accession>
    <name>N1QHM3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sugar_tr-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SEPMUDRAFT_149778</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760075.1">
        <property type="nucleotide sequence ID" value="XM_016905763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QHM3"/>
    <dbReference type="STRING" id="692275.N1QHM3"/>
    <dbReference type="GeneID" id="27902900"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_43_5_1"/>
    <dbReference type="OMA" id="LYYIHCQ"/>
    <dbReference type="OrthoDB" id="5290825at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000100">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF4">
        <property type="entry name" value="SYMPORT, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11790)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="434"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="503"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="535"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="110"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EMF11954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="619" mass="69323" checksum="D4282E5F00364780" modified="2013-06-26" version="1">MEKSGQVYHEGPDEIRQKSVVESINLNRNVDAKISNPLAGISYADLMTDVEQFAHQKGLNDQLELLKKGALIAQDPANFESLEQLDEHEKEFLRYEAAHRWRHPFQLYITIIVCSIGAAVQGWDQTGSNGANLSFPQEFGIGFGETIGHPNQVRDSWLVGVVNAGPYIGSAFLGCWLSDPCNFYFGRRGTIFISAVFCLITPIGGAVSQTWEQLFITRLLMGIGMGLKGSTVPIFAAENSPARIRGALVMSWQMWTAFGIFLGFCANLAVYRVGDIAWRLQIGSAFIPAVPLTLGIYFCPESPRWYMKKNRYQKAYKSLLKLRFHPLQAARDLYYIHCQLQVEASIVGKSNYLSRFVQLFTIPRVRRATLASFVVMIAQQMCGINIIAFYSSTVFRQADASERDALIASFGFGLVNFVFAFPAIWTIDTFGRRALLLFTFPQMAWTLLAAGLCFLIPMSAGDARLGAIALFIYLFAAFYSPGEGPVPFTYSAEVFPLSHREVGMGWAVATCLFWAAVLSISFPAILAALTPTGAFGFYAGLNVIAFVMIFLFVPETKQRSLEELDYVFAVPGRQFVRYQTTKALPWWFNRWVLFRKEAKLEPLYSFDQTIERSEKVGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1QHS2</accession>
    <name>N1QHS2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_49753</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758809.1">
        <property type="nucleotide sequence ID" value="XM_016909130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QHS2"/>
    <dbReference type="GeneID" id="27906267"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="OMA" id="QRRKYMG"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17327">
        <property type="entry name" value="MFS_FEN2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF24">
        <property type="entry name" value="NICOTINIC ACID PLASMA MEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="337"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="396"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="40"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF10688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="478" mass="52895" checksum="7AC13F2304A9D618" modified="2013-06-26" version="1">MNGVAADTNASCIGEQDALQDIAIDPKEEAKLLAKLDLFLMPVIMLVYLSCFLDRSNIGNVKVAGMPEDIGASAQEFSTAVSIFYATYVLSETPWAILLKKLTPRLLLTGLAMVWSLVTIFSGFIQNIGGLYAARLILGACEGGLFPGLNLYLTMIYRREEQAKRVSYLFVCTAIAGAFGGLLAYGILHMDGIGGYAGWRWVYIIEGIFSVVIAIVVWFGLPNDPGKAYFLTTKQKEIMSQRQIQRAAYMGSEEFDWEEVQIAIKDPKVYISGLIQFCQDILLYGFSTFLPSIISEMGYNSYETQYLTVPVYAVGGLSFVSLAFLSDRYELRAPFLLFANMFGIIGYILLLVTSLPVGVRFFATFLCAIAVYTGPGLNLTWLNVNSAPHYRRATSIGLQQTIGNTAGIVAGQIYRKAPYLLGNGFSLGAICFGQFVIVAKMVYIRSCNRTKDRIARGEVADRRRVKTGDWALDFRYHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>N1QI07</accession>
    <name>N1QI07_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA polymerase kappa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_146018</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765007.1">
        <property type="nucleotide sequence ID" value="XM_016903402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QI07"/>
    <dbReference type="STRING" id="692275.N1QI07"/>
    <dbReference type="GeneID" id="27900539"/>
    <dbReference type="eggNOG" id="KOG2094">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012348_11_2_1"/>
    <dbReference type="OMA" id="EVYTRQV"/>
    <dbReference type="OrthoDB" id="1747274at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:error-prone translesion synthesis"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="PolY_Pol_IV_kappa"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DNA polymerase kappa subunit"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Polymerase (DNA directed) kappa"/>
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    </dbReference>
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        <property type="entry name" value="Putative DNA-directed polymerase kappa"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
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    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
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        <property type="entry name" value="DNA_polymerase-Y"/>
    </dbReference>
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        <property type="entry name" value="DNApol_IV"/>
    </dbReference>
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        <property type="entry name" value="Rad18_UBZ4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002677">
        <property type="entry name" value="PRK02406.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11076:SF33">
        <property type="entry name" value="DNA POLYMERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11076">
        <property type="entry name" value="DNA REPAIR POLYMERASE UMUC / TRANSFERASE FAMILY MEMBER"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00734">
        <property type="entry name" value="ZnF_Rad18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UmuC" evidence="8">
        <location>
            <begin position="114"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="610"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="467"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="644"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF16886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="660" mass="74989" checksum="04E1495BB48BFD98" modified="2013-06-26" version="1">MAEECHREEEGKQQQHEHDTLKYSLLGPSLTKSGQDGVDQTAVSEIIYQASKGSKYFANEENRDKTLTLKINSLLAKKRELQRIEIQGGLKKEMKRADDYIAELECKRDLSQTLVHIDCDAFYAAVEELDNPDLKNVPFAVGKGVLTTCNYEARKYGCRSGMAGFVADKLCPQLIHVPLNFEKYTAKARQVRAVLEQYDPRFESASIDEAYLNITKYCQDHNMDPEDAVSQMREQVFQETKITISAGIAANAKLAKICSNKNKPNGQFKLPSERTTILSFMRDLPTRKVNGIGRVLERELDAIGVKTCGDIYSHRQYINRLFGEKAFEFLMGVYLGLGRTDVKPAEEHARRSVGTESTFHDMSDPQELRDKLRRTAESLEEDLKRTEFKGRTLCLKVKLHTYEVFTRQVQPPKAVFTADELYNYSLPMLQKLEKEYPGMKLRLMGLRCTHLVSMKKADLDFFGRARQLNTPNPPQDSKSGVELDEDGWQKWPDAEFEDAAREERQQDLRDLEQLSQEYAERASKDPPPDDAKTFLQSKGIGVGNDYTRYGNGFAWRALLEAESQKEAEASPPKKRIEQWNCPICSLPQVVDERKFNEHIDGCLSRQTIKEIVQQGSSTPERKSAPPLSQASTAKKRGRPAAVTKSEKSSGEKRSKTSFFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1QI24</accession>
    <name>N1QI24_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_46988</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760225.1">
        <property type="nucleotide sequence ID" value="XM_016909024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QI24"/>
    <dbReference type="STRING" id="692275.N1QI24"/>
    <dbReference type="GeneID" id="27906161"/>
    <dbReference type="eggNOG" id="KOG1812">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022048_5_1_1"/>
    <dbReference type="OMA" id="DYQDCPN"/>
    <dbReference type="OrthoDB" id="3650316at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="25"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF12104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="206" mass="23478" checksum="375AF42EFBEF78B0" modified="2013-06-26" version="1" fragment="single">MNITTTTNNQPPPPPPPIPSSSSHPPWTCSVCTSELLSPPHSISHNLICKPCITRLFELALIDETAWPPRWGALLLHHGEFRDVLDADLLMRLDERVRERRCPVAERVYCRQQQCGAFLGRRWGVDEDDESKCEWCGRCGLCTCLRCLRRFEFDDAAKRQVDAAFQGLHRGRDYQDCPNCRQRVQLADGCNHITCTCGIQFCYLCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1QIH5</accession>
    <name>N1QIH5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_89444</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758495.1">
        <property type="nucleotide sequence ID" value="XM_016910500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QIH5"/>
    <dbReference type="STRING" id="692275.N1QIH5"/>
    <dbReference type="GeneID" id="27907637"/>
    <dbReference type="eggNOG" id="KOG1516">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006586_14_0_1"/>
    <dbReference type="OMA" id="NTRCING"/>
    <dbReference type="OrthoDB" id="3200163at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="Gene3D" id="3.40.50.1820">
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        <property type="match status" value="1"/>
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        <property type="entry name" value="AB_hydrolase_fold"/>
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    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
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        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="22"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF10374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="379" mass="42443" checksum="47F2F1A04D0DAB44" modified="2013-06-26" version="1">MTFMPASSPCADMVPLVATAVVQQRPMITVFVNYRLNIFAFGDRTSSKNLALKDQRLAIEWVFKHIAHFGGDADNITLAGESAGAVYVHAHMVTRAPIKRAILQSGSLFLSPPQPEARRMILCDKLETRLRQTGYSSLVEATVPALLESMEEANVGSFWLEMTDELRDWETALGDVEHLLIGDVEYESAIWRNGIEPLAASDIVQCFDLANTDAVRLKEAYNIVEDRPTACKIGALDFINDTRFALPVLEIRDAFLQAGRCAYTYTFDQANPWQQSSRAHHAVDLLMLFGDLDFTHNPGAAAVCREVRNRWARFCHGEEPWPLRDTYAFGPYGTCSVISPDEYASRRRLQACRLLKEIGSDMYNLIYAKLAAGRISLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>N1QIQ2</accession>
    <name>N1QIQ2_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_146201</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765227.1">
        <property type="nucleotide sequence ID" value="XM_016903513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QIQ2"/>
    <dbReference type="STRING" id="692275.N1QIQ2"/>
    <dbReference type="GeneID" id="27900650"/>
    <dbReference type="eggNOG" id="KOG0955">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002663_0_0_1"/>
    <dbReference type="OMA" id="NTSKWSH"/>
    <dbReference type="OrthoDB" id="20839at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15670">
        <property type="entry name" value="ePHD_BRPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15492">
        <property type="entry name" value="PHD_BRPF_JADE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000007">
        <property type="entry name" value="Bromodomain containing 1, isoform CRA_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019542">
        <property type="entry name" value="Enhancer_polycomb-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050701">
        <property type="entry name" value="Histone_Mod_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793:SF107">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793">
        <property type="entry name" value="PHD FINGER PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10513">
        <property type="entry name" value="EPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13831">
        <property type="entry name" value="PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="9">
        <location>
            <begin position="430"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="484"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="177"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="398"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="954"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1132"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="401"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1018"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1032"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1054"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1147"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1163"/>
            <end position="1177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF17106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1177" mass="130458" checksum="9F231577F3022E7E" modified="2013-06-26" version="1">MAASDDSPRRPARTPRTLASIEPSTEPPRKRRLRFEPGGPGGGGRYIDEHGTEMTRAEAVERGLITNAPRSRPRREHTGRPNIVAKAPKHRVLAAADGEIPTRSRSVMTTRPRRERPERYAPPPSTPRPRYSNAAAAAAASQASDGYKPREERSWDEFHPELDLAAGLLVFPADEVDGRTSKQDPKLQNLKLNGLDPNGDVDMQDVSDEGPSQSGRGGTTPQRRKPGRPPRRPESMLSGLGSPPAPRILPLPTHNPKERLNLPKPSYRHYNHFLQYEENQRENKVNYVDRTMAGVGYQESDYFELPPAVLIRLTENQHAEDEADVGLHLAVDGPAESGSGPAVVARVEYDMDEQDVAWLDEINEQRKADGSEPIKPAIFEITMTQIEKEYHALEKRIPKPQPRHAQTHRPRSSSQAAVNGDPNPPGDEPDSKCSICDDGDCENANAIIFCDGCDLAVHQECYGVPFIPEGQWFCRKCKEIGRGTPTCIFCPNVDGAFKQTSTLRWSHLLCAIWIPEVNIANMTFMEPIQDVDKVPKNRWKLSCYICNQKMGACIQCGNKNCYQAFHVTCARRARLFLKMKSQSQGGIDTTALKAFCDKHVPQEWRRINDTENATIEARRWYKHAFKDRKWADSQSAALELAALPSADGDAGNEALAGAEDTIAVSKRRNNKKDQKCSWRLPSGAPVVPQVVMNTVDSSLQRFTVRRKKEFVEKACKYWTLKREARRGAALLKRLQLQLEGFSSMEVTRRNFAAMGSAGGPRLQRRLEFAAMLQKEMKFVTALARQVREREELRLKEVELLRELIDTVYFPIPPLLRPILLRAQKLDEKTGAFRAGFDMLAQRLRERYYTSVSDFSRDLSRIFAQALASAGNPDSPSDADIEAIHNQLNEVKPGSAAHMALTQEQKDLKRLAKRIVKAVKEPLEAAMKKEAELRGLEHEEELRKLDSMGIFASSKSKSLDADGEDEVDKQHTHLRTGPDPSVAAGAEDQTGLVDMLDAGPDDATSDPSLGRDSMIPFANESSVPASKAGSHTSSDPKPSSSKGRNERPTEPLSPPISRSSSRPSGVPASVSGDSSNLNGESHDFLAQGGVPWYLEPFDPIGTTIHEERYTGRAVLRAMSEELSDMDEDTLTELAVTGADAPPNARQTASSSATSAAPGSAVKKPSSKKKRSKRSYWSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJ75</accession>
    <name>N1QJ75_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_130028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765361.1">
        <property type="nucleotide sequence ID" value="XM_016902326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJ75"/>
    <dbReference type="GeneID" id="27899463"/>
    <dbReference type="HOGENOM" id="CLU_1656401_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF17240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="160" mass="17598" checksum="765BC96A2AE805E2" modified="2013-06-26" version="1" fragment="single">SYYPLLLHTFPTISTTTCATPSKSRISSHLFSFLKLKSEPGHVNYSRATEAPVLRRNPRPSSRKASHSSKRTSRSRFTPTYLHTTHNVSSRLLSRRRSAPIRPTAVPSTIVRSTAVRWLPARSTSNAVPARLPTAGATATKKGSRLLGCVSRDAVLLFCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJE1</accession>
    <name>N1QJE1_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 18">Galactose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="5 18">2.7.7.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">SEPMUDRAFT_150697</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:13989"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="2.7.7.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="17">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="16">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 18">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.12" evidence="5 18"/>
    <dbReference type="EMBL" id="KB456267">
        <property type="protein sequence ID" value="EMF10669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016758790.1">
        <property type="nucleotide sequence ID" value="XM_016906339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJE1"/>
    <dbReference type="STRING" id="692275.N1QJE1"/>
    <dbReference type="GeneID" id="27903476"/>
    <dbReference type="eggNOG" id="KOG2958">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029960_0_0_1"/>
    <dbReference type="OMA" id="CFENRGA"/>
    <dbReference type="OrthoDB" id="418412at2759"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008108">
        <property type="term" value="F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00608">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000001">
        <property type="entry name" value="Galactose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000009">
        <property type="entry name" value="Galactose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001937">
        <property type="entry name" value="GalP_UDPtransf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019779">
        <property type="entry name" value="GalP_UDPtransf1_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005850">
        <property type="entry name" value="GalP_Utransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005849">
        <property type="entry name" value="GalP_Utransf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00209">
        <property type="entry name" value="galT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943">
        <property type="entry name" value="GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943:SF1">
        <property type="entry name" value="GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02744">
        <property type="entry name" value="GalP_UDP_tr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01087">
        <property type="entry name" value="GalP_UDP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000808">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00117">
        <property type="entry name" value="GAL_P_UDP_TRANSF_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 18" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="12 18" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="11 17" id="KW-0408">Iron</keyword>
    <keyword evidence="9 16 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 18 22" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 18 22" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 16" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Galactose-1-phosphate uridyl transferase N-terminal" evidence="20">
        <location>
            <begin position="45"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Galactose-1-phosphate uridyl transferase C-terminal" evidence="21">
        <location>
            <begin position="249"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-UMP-histidine intermediate" evidence="14">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="65"/>
            <end position="68"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <begin position="114"/>
            <end position="115"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <begin position="225"/>
            <end position="227"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="380"/>
            <end position="381"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="385"/>
            <end position="386"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <position position="392"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF02744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EMF10669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="414" mass="47145" checksum="906B4A41482C008F" modified="2013-06-26" version="1">MHQILHSADLPRSISPTPTRADFSRADPVPTCCAQGTMPEAILDDISHRRYNPLRGSWVLVSPHRTKRPWQGQQEEASKNVLPQYDPSCYLCPRNKRAQGDANPDYDSTFVFVNDYSAVKEQQAEYAPPKGSGTLASRLLKAESTTGKCYVITFSPSHNITLADMPAQDIMPVIDTWTKIYTAHLDPRSPLAQCASPMSNGTTIEAPRDQYRYMQIFENKGAAMGCSNPHPHGQIWTTTSLPEEPSLELQHMQQYRQEENGSHLLVDYAKLECEKGERTVYENRSFWAGCPWWATWPFEVMVISKSHKRALVDFDQSEKEDLADVLSEVTRRYDNLFETNFPYSMGLHQAPLTGTPEEIEASHFHIHFYPPLLRSATVRKFLVGYEMMAEPQRDITPEQAAKRLRECGGELYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1QJQ5</accession>
    <name>N1QJQ5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ran-binding-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_153394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765556.1">
        <property type="nucleotide sequence ID" value="XM_016907509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QJQ5"/>
    <dbReference type="GeneID" id="27904646"/>
    <dbReference type="eggNOG" id="ENOG502R7I3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014536_1_0_1"/>
    <dbReference type="OMA" id="WDPYNES"/>
    <dbReference type="OrthoDB" id="512915at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008812">
        <property type="entry name" value="Ran_GTP-bd-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31010:SF2">
        <property type="entry name" value="RAN-SPECIFIC GTPASE-ACTIVATING PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31010">
        <property type="entry name" value="RAN-SPECIFIC GTPASE-ACTIVATING PROTEIN 30-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05508">
        <property type="entry name" value="Ran-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="464"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="589"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="649"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="593"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="651"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="682"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="697"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="715"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF17435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="734" mass="81463" checksum="2C08CAA64ED3A0D9" modified="2013-06-26" version="1">MVMVGGWVGPFTWRTVCPVALFVWSDLWLTFFLHGYASLEMDLLLHKVTQQAVQYAIRSGITMTSAYCIKECSRLLKQAPKRSPERHELLQLQLDLEQKIRMIAQPITMIELIAARGNTSLESALSLCRDLRYDIQALGQRLDKAAREEQHLRQHARNGVSREDADHELVAIISQVKLLLARIDGAVPLITLAITTSGCSLSTSLSGTISPSRLLQASTFLTAADTSFAHSPMMPRQVGPTWTCCLYMLFASHASRSESHEATWKEVIHKARVKLWRVPLEKLYSLPGEPSSPDFCDGRSIPSDDKAAEFAYQLSIVEDLDDGRVHTFEDDEPQPGSFDDVPLAGIRDIVPIHEISKIFYADTGKVLGIGGDDEITHPCLLLRRDWHAEPPRRMTRPSHAQTFSADNDEDDDDENEQSQIDAQIQREATPDVSSHEEAMPRGHSWRLPPDLDPEWMAFQVFVEDDTSESEDEESEHPRSSPSTSFEPSLAMANLNINSSPPDTPIKPRSALTLSPEKPTGPIIKTTLSLLEMLLKLSALQQFRQESHLAVEDELLNFFLEDSGTAGAGAEKQHRQEVRRAAIQRVGFDPYDESPIKRRGEEYISRADGSPRSLRGSPKPTSIPHNEEYKYQTPALDLSRSPQDLLLANRGVASSPSPLPTGSQQTPPRSFTPEKGSYAQRRAAPVNSNASQSAASSEGSGTPPSTQKTRAALLRARNDTKSRSPLHETHPSGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKV0</accession>
    <name>N1QKV0_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_149677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF11801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016759922.1">
        <property type="nucleotide sequence ID" value="XM_016905703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QKV0"/>
    <dbReference type="STRING" id="692275.N1QKV0"/>
    <dbReference type="GeneID" id="27902840"/>
    <dbReference type="eggNOG" id="ENOG502RFKG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1107513_0_0_1"/>
    <dbReference type="OMA" id="GAGAIFM"/>
    <dbReference type="OrthoDB" id="3650407at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110413" description="Extracellular membrane protein CFEM domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF11801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="25684" checksum="3CE3FBA7037F790D" modified="2013-06-26" version="1">MHNTNVLLAFAATAICAVRGQGLGLDNNDVPPECRSICQPVVDVEASCDNQFDDDAQQYRNCVCQNQSASQALPACDQCAAQYPNFFIDRNDDDGPDIDDNEISAWARICGLPAIQPNGTGPMSSGVRPPASFTTSMMTTTQIYDCDDPDDIINPTGTGRGDRDDPRCTRTTVVPVVGVVAPMTTGPSGPAPTVVSVSYTTSTGTNAAGSPAVFTSAVSTYTGTGGAALPTAAAGYFGAGAAALLAAFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1QKY3</accession>
    <name>N1QKY3_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal_L24e-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SEPMUDRAFT_145566</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764399.1">
        <property type="nucleotide sequence ID" value="XM_016903136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QKY3"/>
    <dbReference type="STRING" id="692275.N1QKY3"/>
    <dbReference type="GeneID" id="27900273"/>
    <dbReference type="eggNOG" id="KOG1722">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106411_0_0_1"/>
    <dbReference type="OMA" id="PGHGKKM"/>
    <dbReference type="OrthoDB" id="1727108at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.20:FF:000002">
        <property type="entry name" value="60S ribosomal protein L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056366">
        <property type="entry name" value="Ribosomal_eL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023442">
        <property type="entry name" value="Ribosomal_eL24_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01073">
        <property type="entry name" value="RIBOSOMAL_L24E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL24-related N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="89"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="89"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EMF16278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="161" mass="17989" checksum="371BF94C494A87C2" modified="2013-06-26" version="1">MRTYDDTFSGAKIYPGKGKLFIRSDSKIFRFQNGKSESLFLQRKNPRRIAWTVLCRRQRRKGISEEQAKTRRRKQVKAQRAVVGASLDVIKERRSQRPEARSAARKQAIEDGKKKRAATESAKKAEKAKTAAKSAAGQTTGRVVGKQAAKGSAPKVKATTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>N1QL28</accession>
    <name>N1QL28_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transmembrane emp24 domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_146113</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765118.1">
        <property type="nucleotide sequence ID" value="XM_016903460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QL28"/>
    <dbReference type="STRING" id="692275.N1QL28"/>
    <dbReference type="GeneID" id="27900597"/>
    <dbReference type="eggNOG" id="KOG1692">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066963_4_0_1"/>
    <dbReference type="OMA" id="MQVRDRN"/>
    <dbReference type="OrthoDB" id="62956at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016050">
        <property type="term" value="P:vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110422" evidence="9">
        <location>
            <begin position="21"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="10">
        <location>
            <begin position="30"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF16997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="202" mass="23043" checksum="F01DD613C9FE0020" modified="2013-06-26" version="1">MAVLFSVVVAVLSLCSLSSAHNILLRAHSRECFHENLHKDDRMTVTFQVGDREFGGSGNLDIDFWIQMPSIGYQVHNLAVSAGDHTFEAKEDGRYTYCFSNEAWSANTKEVSFNVHGVVYVPETEAPQDPLDKEVRAMSELMASVKDEQGYIVVRERTHRNTAESTNARVKWWSLFQIGVLVSEGVFQVWWLKRFFEVKHVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>N1QL52</accession>
    <name>N1QL52_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-processing factor 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_122442</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016901769.1"/>
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    <dbReference type="STRING" id="692275.N1QL52"/>
    <dbReference type="GeneID" id="27898906"/>
    <dbReference type="eggNOG" id="KOG0282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022571_0_1_1"/>
    <dbReference type="OMA" id="TLWHPHE"/>
    <dbReference type="OrthoDB" id="10257301at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000386">
        <property type="term" value="F:second spliceosomal transesterification activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000389">
        <property type="term" value="P:mRNA 3'-splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:mRNA branch site recognition"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000034">
        <property type="entry name" value="Pre-mRNA-processing factor 17, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032847">
        <property type="entry name" value="PRPF17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43979">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43979:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="2 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="200"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="244"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="336"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="468"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="50"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF17017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="501" mass="56227" checksum="14C1D46729E33E20" modified="2013-06-26" version="1">MALVPARNGANGPPTRASQLVETKQFQTSTKGKVPTGYAEEIAISEHSFRDLHRGVERQHAVGKKRKRETKGDSSTVYGAGAYKGPWAKYEERRIDSDSGEEIEVEVEGDESGEEEVIYEEDAIAPVPTKGSKAGTSYDKVGHDKETSTFEGSQQYDYQGRTYMHVPQDLDVDLVGDFENMNLRCFHPKKLIHTYTTHGRNAHEKALTSLKFFPNSGHLLLSAAADGKVRIWDVYHERELLRSYNGHTKSVVDVDFTPNGTRFLSASYDRQIKLWDTETGQCISRFGTGSTPHVVRWQPDDPSGHEFLAGMHDNKIVQFDTRLPADGEKKNPVQEYDHHLGPVNTITWCDENRRFITTSDDKSLRAWEFNIPVPIKFIAEPYMFPMVKSASHPAKGAVLLQSSDNTIKVYNTGEKIRQNRKKDFRGHNNAGYAIDLAVSPDGGIVASGDSGGFVCFWDWKTCKMWHKIRASDAAVISVAWHPRESSKVVTGDLNGVVKYWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1QLD5</accession>
    <name>N1QLD5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ERCC1-like central domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SEPMUDRAFT_146885</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERCC1/RAD10/SWI10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF18005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016766126.1">
        <property type="nucleotide sequence ID" value="XM_016903937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QLD5"/>
    <dbReference type="STRING" id="692275.N1QLD5"/>
    <dbReference type="GeneID" id="27901074"/>
    <dbReference type="eggNOG" id="KOG2841">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041616_1_2_1"/>
    <dbReference type="OMA" id="RIVLCMV"/>
    <dbReference type="OrthoDB" id="10262814at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070522">
        <property type="term" value="C:ERCC4-ERCC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22325">
        <property type="entry name" value="ERCC1_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000001">
        <property type="entry name" value="DNA excision repair protein ERCC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047260">
        <property type="entry name" value="ERCC1-like_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004579">
        <property type="entry name" value="ERCC1/RAD10/SWI10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00597">
        <property type="entry name" value="rad10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12749:SF0">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12749">
        <property type="entry name" value="EXCISION REPAIR CROSS-COMPLEMENTING 1 ERCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03834">
        <property type="entry name" value="Rad10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC1-like central" evidence="8">
        <location>
            <begin position="88"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="304"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="366"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="314"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="325"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EMF18005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="410" mass="44802" checksum="3105B4373957F4AA" modified="2013-06-26" version="1">MADEIEDDGPRRPAPTVSRTGTATTALNPSHASASASGSRQHPLPHQHVAPARQQQGMDRQSGASSTTKTGVQQPKPQALPRRAGPASIIVSPRQKGNPLLEKIKSLPWEYGDIPADYVLGVTTCALFLSLKYHRLHPEYIYTRIKNLQGKYALRIVLCMVDIQNHEESLKELSKTSVINNVTIILCWSAAEGARYLELFKTYEHAAPTSIKQHQSTSYSDRMVDFVTTPRSINKTDAVSLVSQFGTLRTAVNARHEEVASIGGWGEKKVQQWVGSVTEPFRVQRAAKRGLQLENMVASQPISLSRGVARAEPESTTDTPTFSHADTDHQADADRRPPIRLAEPGLGADLAVEDEAVFAEAMNAAMLPTKKASGPVREEPVAEPSRKRKQDEETLSDGVMAALAKLRKPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1QLN2</accession>
    <name>N1QLN2_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_67950</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016760362.1">
        <property type="nucleotide sequence ID" value="XM_016909801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QLN2"/>
    <dbReference type="STRING" id="692275.N1QLN2"/>
    <dbReference type="GeneID" id="27906938"/>
    <dbReference type="eggNOG" id="KOG2307">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056777_0_0_1"/>
    <dbReference type="OMA" id="YKLMGED"/>
    <dbReference type="OrthoDB" id="332281at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009316">
        <property type="entry name" value="COG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024602">
        <property type="entry name" value="COG_su2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06148">
        <property type="entry name" value="COG2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 2 N-terminal" evidence="10">
        <location>
            <begin position="55"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="185"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF12241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="303" mass="33816" checksum="409961C380F90916" modified="2013-06-26" version="1">MSRFQIGATPTTASAVSTPAGEYSPTSTPAQRYSADNYDDDDDDISTLPYPTELPRSDFLQPQFDAQTYLSSLRNRHQTLEDLRSDLRSRSQLLNKELLDLVNGNYEEFLSLGADLKGGEEQVEGVRVGVLGFGREVEGIKKDVQERKDEVKGLLDEKKNIRREVVIGRLLLDINERLSELESSLGINMDAEEEEEDFDDDGDAGDDDSDATTLGRAQLRRLQRHAEQFLMVERLIERIGPDHPFLVAQKGRLDEIRKTLLLDLATALRQAKADKSSESVLLAMKLYSDLGAEADSVKVLKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1QLN4</accession>
    <name>N1QLN4_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DnaJ-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_32469</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764754.1">
        <property type="nucleotide sequence ID" value="XM_016908496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QLN4"/>
    <dbReference type="STRING" id="692275.N1QLN4"/>
    <dbReference type="GeneID" id="27905633"/>
    <dbReference type="eggNOG" id="KOG0691">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045130_1_0_1"/>
    <dbReference type="OMA" id="QAYKLKA"/>
    <dbReference type="OrthoDB" id="442087at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051938">
        <property type="entry name" value="Apopto_cytoskel_mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
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    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44145">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY A MEMBER 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44145:SF3">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY A MEMBER 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="9"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="230"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="365"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="245"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="272"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="379"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF16633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="389" mass="45236" checksum="4A1A8FA875C9F046" modified="2013-06-26" version="1">MAPPITTEDYYRVLEVSQTATTELIRKSYLRLALKHHPDRNGSKEGFQLVFQAYETLNDENRRRQYDLLYPSINANRSSAQSASDEAAQIVALRKLNEERITRWRLTRSILDSAIFELQRSIRRQQNVVDVLAGIISKAEAAEDAQKKNWGIWFFNQVFKTAVARKYEIARKDRQRQERRIEKDFKERKIETLKAQLQEKEKMLQQSEKENSAADARHDLALRAAEARIRQRRAGEQQQQNSKAAETERMEKARREEQARQQEKRAREATETWRQQQSRAPTASTAPNDPPNRQAEQTPAYDWFRSTRPTFTHSPHQTPPSICTHGGWWDKVQGRTTCTECDEVWTYLLMCPGCGKQACPKCQRDFRPQFPDRAATTRGGRKGKKGRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>N1QLR6</accession>
    <name>N1QLR6_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_150007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456265">
        <property type="protein sequence ID" value="EMF12316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016905908.1"/>
    </dbReference>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018589_0_1_1"/>
    <dbReference type="OMA" id="CPDIRKM"/>
    <dbReference type="OrthoDB" id="5405297at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="478"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF12316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="536" mass="58832" checksum="C9EBF232DC4B0119" modified="2013-06-26" version="1">MLCDLRDLSRCAMTCRKWYATAQQQLYTSVRIDAVHYCELEEILAEKRRKASKGHFRNKSAVEPVEVPNIRLQLLCRTVREQSNLASQALFLKIPYMTRETAKGDLARTVAALPNLRYVDLPDGFYSGDPTCLGLRQELQARCPDIRKMIYRSGSEDALELLAHRHWQAIETLELVNLSVEPATLRVVLGSLPTLRDLTLSDMPWIDDSVLMPAQGQLPDFPAVQFLRLKHTPNLTAQGLSAWLEAPHVREMLFSLSLDDTGVTIQDLHQVLWDATHLSHLAVVETVSKSLSLAAQQLPPLSSISLATLHFEISSAEDVHGLQKPAESYYAYLASSLHQNALPALTTLYVRDQSFPELLLLPPLHMGLPGGNSDRGSLKNKPSGMTANSLSSPFQGGGFNQTLEVFSKGIDELEWVFTSITPQNNPADKRSSVIASGGRPISAYSAGRGLGPQWAQGGFGGEARKSVVVGNGFGGFLAVPQEEAPRPRTSDGAASPGRGFGSFGHRSDRSSFLPAPPKLFGEGAHQRRGSKHDLWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1QM89</accession>
    <name>N1QM89_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">F420H2 dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_146460</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the complex I 30 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765543.1">
        <property type="nucleotide sequence ID" value="XM_016903665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QM89"/>
    <dbReference type="STRING" id="692275.N1QM89"/>
    <dbReference type="GeneID" id="27900802"/>
    <dbReference type="eggNOG" id="KOG1713">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042628_0_0_1"/>
    <dbReference type="OMA" id="PCRKNRF"/>
    <dbReference type="OrthoDB" id="37721at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.80:FF:000002">
        <property type="entry name" value="NADH dehydrogenase iron-sulfur protein 3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="entry name" value="NADH:ubiquinone oxidoreductase, 30kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01357">
        <property type="entry name" value="NDH1_NuoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010218">
        <property type="entry name" value="NADH_DH_suC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020396">
        <property type="entry name" value="NADH_UbQ_OxRdtase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01961">
        <property type="entry name" value="NuoC_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004733">
        <property type="entry name" value="PRK06074.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10884:SF14">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10884">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="Nqo5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00542">
        <property type="entry name" value="COMPLEX1_30K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase 30kDa subunit" evidence="10">
        <location>
            <begin position="113"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="264"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="289"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EMF17422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="298" mass="33667" checksum="E4BB2354AAD60D17" modified="2013-06-26" version="1">MSLARSVHRAATRHGASLPMTKSTAPATATATAIRGFAAAASRGKELAGQIGDLKNMRHSPRNAPEKLHVPIVNPADKYQAKADSLHAYGQYLMSCLPKYIQQFSVWKDELTIYIPPAGVIPTFSFLKHHTAAEFTCVADITAVDYPTRDQRFEIVYNMLSVRHNSRIRVKTYADEATPVPSITSLYDGANWYEREVYDLFGVFFVDHPDLRRILTDYGFDGHPLRKDFPLTGYTEIRYDEEKKRIVVEPLELTQAFRNFEGGSAAWEQVGPGHERKPETFTLPTPKPEPPKEEEKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1QMD6</accession>
    <name>N1QMD6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_32290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765204.1">
        <property type="nucleotide sequence ID" value="XM_016908489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QMD6"/>
    <dbReference type="STRING" id="692275.N1QMD6"/>
    <dbReference type="GeneID" id="27905626"/>
    <dbReference type="eggNOG" id="ENOG502RXU0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033727_0_0_1"/>
    <dbReference type="OMA" id="IPLFVNH"/>
    <dbReference type="OrthoDB" id="18110at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23524:SF1">
        <property type="entry name" value="MRH DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23524">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="409"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="490"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="516"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF17083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="549" mass="57397" checksum="4FB93BB52C20ECEF" modified="2013-06-26" version="1">MDDESTTTTATKRPRFFPTLTATRLQIATYLLGIALFSIAFLVFVNSSISFVVTDIIGQKEGVGDAVGTLGFADECLALVACPLWGLLSDRIGVRTVAVLGYSIVAISLACLVQSTNVFPDLLMGRLGFSLGAAACTTMVTAVLPSMVMPASAAEDEDALSTKGGSSAGTSQLAGLVGFFTGAGALVALSIFLPLPAHLQQDGFGPSESVQVSYYIVAVVALCVAVCIFVGLRNLPGEEKKSISGLFRAPYDETTTTGPEGHPHITLTPQPSYVLLAKESLKLGFTDPAIGLGYLGGFVARASSVGISLFIPLFVNAYFVRTGLCTSNPDNLTDIKRNCQRAYKLAAALTGIGELAALICAPLFGWAGGRAARSQSEWPLLAATALGVVGYVSFGLLRNPDPFHVGGQWAIISVILVGMSQIGAIVCSLALLGRGVNQATSRTCRPIARDLLQNESTTEEEGAPLLQEVSRSGSPPTFDRARLSGSIAGMYSFAGGAGILILTKVGGLLFDKWHTGAPFFLMAIFNAILLVAIVVIRGGSLLHKHRVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2023-05-03" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>N1QMI9</accession>
    <name>N1QMI9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_146269</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765289.1">
        <property type="nucleotide sequence ID" value="XM_016903542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QMI9"/>
    <dbReference type="GeneID" id="27900679"/>
    <dbReference type="HOGENOM" id="CLU_1918398_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF17168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="132" mass="14334" checksum="7D9F018581B89E14" modified="2013-06-26" version="1">MDALGATGNEQVQAAAQTVLNDLYRVQDLVNLFSQRLSMARRRRSAVGGGEAGSDILAAMYNTSTTLSEVSGRVDRSEIYANERTASIGAIRKRFATTFTSCQLRDGADPSARMSKHSGLWLPMSSSRELET</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1QML8</accession>
    <name>N1QML8_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Calcipressin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_145897</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RCAN family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF16714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764835.1">
        <property type="nucleotide sequence ID" value="XM_016903330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QML8"/>
    <dbReference type="STRING" id="692275.N1QML8"/>
    <dbReference type="GeneID" id="27900467"/>
    <dbReference type="eggNOG" id="KOG4019">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050705_0_0_1"/>
    <dbReference type="OMA" id="RIVCSFH"/>
    <dbReference type="OrthoDB" id="17212at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008597">
        <property type="term" value="F:calcium-dependent protein serine/threonine phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000503">
        <property type="entry name" value="Calcineurin binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006931">
        <property type="entry name" value="Calcipressin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10300">
        <property type="entry name" value="CALCIPRESSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10300:SF14">
        <property type="entry name" value="PROTEIN SARAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04847">
        <property type="entry name" value="Calcipressin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="228"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF16714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="296" mass="32037" checksum="C38DA64737A670FF" modified="2013-06-26" version="1">MMHLPTTTTTTTTTPTASPPTTPTTEQQPPASYDDQMAAITMSPVSTSSPTGAMKRRHSPSLSIDLSTLPALSQPATPSNTLLITNLNAPEIFQGASLESIRAAINQHATIHTFSPLKSFRRIIVSFYTVEDAINLRQVLDGESVLGNRVRVYFGTETKINDQEDQHLQAPQSQKLFFISPPPSPPVGWEVRNEEPPNKEVHADDLAVALSKLHARPAADQALYDDVEGKTPVSAGGGRSRSSTLVFDPQEHGRSPDLPAIAVEDTTDSPLPLSPVDGTTKQFIHTARPPVELMEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1QN44</accession>
    <name>N1QN44_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_146797</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016766003.1">
        <property type="nucleotide sequence ID" value="XM_016903872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QN44"/>
    <dbReference type="GeneID" id="27901009"/>
    <dbReference type="eggNOG" id="ENOG502S8CY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004543_1_0_1"/>
    <dbReference type="OMA" id="NDTRIFS"/>
    <dbReference type="OrthoDB" id="5346713at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004111022" evidence="2">
        <location>
            <begin position="30"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="543"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="645"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="700"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="924"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1076"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="246"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="279"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="470"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="548"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="578"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="645"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="754"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="781"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="967"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="978"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1112"/>
            <end position="1130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF17882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1130" mass="122536" checksum="00C3A58C4BA12171" modified="2013-06-26" version="1">MPTVVSTLGATATITSLAFLGLVLTSSDSSPGASSSSHRNSNSNNGNRDSAADELQHHLPDGPTSGKNSRGYIPGTARAAADMSTTTTTTVETYIARHQLFAPLPTRRGDGTRTRSNSANTPINRPGSKRHSYAGFSTTGMDRSLRRPQQQEKQQREEYSGASDTTPASGPAANGAWLRRLSSTLTTSRDSSRTPSSRSRPDSAAVSHSNASLAISQTRSPTPILNESTISQPGNALGANKLVKRSASSSSANGSSTSRIPVFRRPATSHQRSATLQNRLSSSDRSSRMTSRSGAGETGTHAAHQRSYFSPRIVLSEQLPMSKQRGSTGIPNPIRRLYADRKHTPTLMSARELVFVDAVGVDNGMNEFEHNTYSSGPGVAKSTASSPFPTPVAHFEESASPRRSFSIGDLLSTGPQPLWKRPSTSNSIRPWSSRTIRRPRPASMGGLVDTTTRNDSDRPAKRRDLTDPASSQRSIYSSSSSNYTFQPDITHQVGLHLNGELSQAQNAVEPISASASLSRAQTPDQNGTPFDAGITTAARIPRGSATPSEIASSIGSESGRHSIGGNSTDYQSDVYYDSIPTRTTRSSSGRRGPPIDTIFDESPPTFSSGRSTRLRDFLSDGHEHNERYSTIEEEGSVVSTPVRSLRNRSMTSTPSARPGAMQVFSSSPPVMRLMPDADDIDWELADEERLDGGRIIQQRASNPALGKLHPGQTIPPRFSAALRPGHTRSAKSTPDRHGYSPLDKPSLFDWAEPQPSPSHPNCSPPRPRTVHGKKDQDSRGSRPAGRRPPSGMHARSHSVPVVPDSDSKRSSVVANKFGTWGVGSKGVTEDWNDDFDFEEPAGSVHDKLEQDSRRVDSGHAMFVPKSIREQQQNVVANISLLREWGLLIEELKELRVRAVTLNMLTGPYAQAWREVDAMIELADQESEEDTLEPRRTPPSSPGFDVTAFEDVTPVRANRLSGQAKLGPQTSDPDTWSGNDHERSPKLVTRPRKDSELVAQKVIAALQSKRSAVESHAIPMPGGHYKKVPFDTATLRHIVPYVSGLKRKVKDALRETEGLYTSPQRRKTVDNTETTALRSIFGSPQDDDVTNRRLSRRKQATADNDGLGLPLPDQSTSLTNSMENLSIPSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNB6</accession>
    <name>N1QNB6_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AAA-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SEPMUDRAFT_146240</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765270.1">
        <property type="nucleotide sequence ID" value="XM_016903536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNB6"/>
    <dbReference type="STRING" id="692275.N1QNB6"/>
    <dbReference type="GeneID" id="27900673"/>
    <dbReference type="eggNOG" id="KOG0737">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004223_1_1_1"/>
    <dbReference type="OMA" id="RNCNSHE"/>
    <dbReference type="OrthoDB" id="39734at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056027">
        <property type="entry name" value="DUF7608"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051701">
        <property type="entry name" value="Mito_OM_Translocase_MSP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644:SF56">
        <property type="entry name" value="AAA ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644">
        <property type="entry name" value="AAA ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12920)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24581">
        <property type="entry name" value="DUF7608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="612"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="118"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="512"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="512"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="535"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EMF17149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="890" mass="97469" checksum="46B75D781DF7017C" modified="2013-06-26" version="1">MALPVSNEPYEQVNQHALLRWAVLQAETGVNAAFSVARHAPSASSRAASRLDLSLSCEDPNAHASMDDFVEDLATISGANLIRLDANDLADLSADYVGQGSDSPGSLSNLAYDVFGGYKSPTTPSARRTEDEDEEPLDEDDMDEEEDEQEDRRSRSGMGNSVPWSLNSIRKRLMSRPYHFAQELDKVGPGDIIVEMGPRYSKPFGQVTSVSSRNDPGYDEARLCSLLDQILDAPKQSRGGSLQRRSSLHTAEAGKEGGIAKSDVSYQALSRMWRSSAGCWLPDIAGLIASLVLRASKPDSPHGSSLILEPSGTDLGNVSANDSTERTIVHVRDLRDIVCSRVGEGIIRRLVSVVQKRRRAGQQIVIVGSSCHQVSNFVLVPQALDDFITISVPAVFRMSKHDQVNFKPTTSAIDNPATPPYSRILEINLRHIQRMLNSLRPGDTVDLFTAPAQRQLRGADDVLSKEVMTFDMIQRIVLTAIGLSEVHAVADHVNASHVGLATTITRQAAQTERDWTEHQRLKETRGPVPDGVTGSEASSTASNKPSTIEKIKKDLDKYESKLLPGVVDAENIKAGFGQVHAPLETIEALKTLTSLSLLRPDAFRYGVLAADRLPGLMLYGPPGTGKTLLAKAVAKESGATVLEISGAQIYEKYVGEGEKMVRAVFSLAKKLSPCIVFIDEADAIFGSRSNAGNRNTHREIINQFLREWDGMDMHNVFIMVASNRPFDLDDAVLRRLPRRLLVDLPVAKDRESILKIHLHDEVLDETVDLPKLAVDTPLYSGSDLKNVCVSAALACVREENELVESKRKEGEEFKLPAKRTLSSRHFEMAVKEISASISEDMGSLTAIRKFDEQYGDRRSRRRKTAYGFGIGPVDVDDARVRQSSTGGASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>N1QNE1</accession>
    <name>N1QNE1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_123009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456260">
        <property type="protein sequence ID" value="EMF17678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016765799.1">
        <property type="nucleotide sequence ID" value="XM_016901818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1QNE1"/>
    <dbReference type="GeneID" id="27898955"/>
    <dbReference type="HOGENOM" id="CLU_1908002_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF17678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="133" mass="14387" checksum="995AA3861AF76950" modified="2013-06-26" version="1">MLIMHICLERLLSPAGAYRDGSFLGPAFSWLALLISVVVPLLFRHGLGLLLVLGTLFLPHCRNIQVVGRFVSFGLAVDRAHMAAQEPRILPCCEGLGAGAKVASDLTWLYDECVPEVGHGCECPTSVQPMMRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2022-12-14" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>M3AST5</accession>
    <name>M3AST5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_152195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456271">
        <property type="protein sequence ID" value="EMF08569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756690.1">
        <property type="nucleotide sequence ID" value="XM_016907295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AST5"/>
    <dbReference type="GeneID" id="27904432"/>
    <dbReference type="HOGENOM" id="CLU_2623564_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF08569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="78" mass="8775" checksum="603ECF309D037696" modified="2013-05-01" version="1">MAYTPPTNGSYIYGKLNSSRTNCRAHASSSEEYIRVVEPRGQTRRRPSESTPPQLYLIKVPRLYATLPGQSNETTLLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>M3ATA7</accession>
    <name>M3ATA7_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SEPMUDRAFT_158881</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF08749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756870.1">
        <property type="nucleotide sequence ID" value="XM_016907811.1"/>
    </dbReference>
    <dbReference type="STRING" id="692275.M3ATA7"/>
    <dbReference type="GeneID" id="27904948"/>
    <dbReference type="eggNOG" id="KOG1178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_37_5_1"/>
    <dbReference type="OMA" id="CPTEYLM"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009403">
        <property type="term" value="P:toxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05930">
        <property type="entry name" value="A_NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF20">
        <property type="entry name" value="HYBRID PKS-NRPS SYNTHETASE APDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
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        <property type="entry name" value="ketoacyl-synt"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="2"/>
            <end position="438"/>
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    <feature type="domain" description="PKS/mFAS DH" evidence="12">
        <location>
            <begin position="948"/>
            <end position="1254"/>
        </location>
    </feature>
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        <location>
            <begin position="2415"/>
            <end position="2492"/>
        </location>
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    <feature type="domain" description="Carrier" evidence="10">
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            <begin position="948"/>
            <end position="1080"/>
        </location>
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            <begin position="1101"/>
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            <begin position="2499"/>
            <end position="2599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2617"/>
            <end position="2638"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2924"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
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            <begin position="2513"/>
            <end position="2539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="2553"/>
            <end position="2562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
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            <begin position="2580"/>
            <end position="2589"/>
        </location>
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        <location>
            <begin position="2936"/>
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        </location>
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    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="8">
        <location>
            <position position="980"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="8">
        <location>
            <position position="1161"/>
        </location>
    </feature>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EMF08749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="4184" mass="453827" checksum="EFD2E83548A9FADE" modified="2013-05-01" version="1">[encoded data, 4184 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M3AU21</accession>
    <name>M3AU21_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_136301</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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            <end position="149"/>
        </location>
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        <location>
            <begin position="312"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF08974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="360" mass="41993" checksum="ED248EC7AC91F3AA" modified="2013-05-01" version="1">MKINERKMPETLFDFTYITYIRKVLMFLATAPEIPRTTKLKHMAKCTKWKPWKTVAVLQAACRARQLDTCGCVIKKDYCRVLNDWEEAQEVTAAEVTEPPCTANEIPSHESHKRHDSKEIAPTDTTNLTNKESLHTNTTPRPREPRARTTRQDLRNARAELLSLHQKLPLALAQAQKAHISRLKISPEGTVVPRISELRAGILLFDVEMVHEEDIPHYCKATLSQKIWLEFELQQFFNLIIEIQSRNSRDTKLVEQDSGGQLKEMLKLVDQLVAKRNEILERAYRSNNGANVEDYTNWPLSFDMKTEDLRDEATMTRRLRELQREIEWLEGDLAKWEAAIREWEDLMGREISFYSLPFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M3AUC5</accession>
    <name>M3AUC5_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SEPMUDRAFT_151926</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RdRP family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="1"/>
    <dbReference type="EMBL" id="KB456270">
        <property type="protein sequence ID" value="EMF09089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_016907130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AUC5"/>
    <dbReference type="STRING" id="692275.M3AUC5"/>
    <dbReference type="GeneID" id="27904267"/>
    <dbReference type="eggNOG" id="KOG0988">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001366_2_0_1"/>
    <dbReference type="OMA" id="GIMDETN"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057503">
        <property type="entry name" value="PH_RdRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF17">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25358">
        <property type="entry name" value="PH_fung_RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RdRP-like PH" evidence="4">
        <location>
            <begin position="130"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="RDRP core" evidence="3">
        <location>
            <begin position="443"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EMF09089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="1253" mass="141471" checksum="8584E6AAA410FCA8" modified="2013-05-01" version="1">MNVFVQNLPDNVTYTEVERTFDRPLRQCGVRDFHIEKHRGRGNATITILDVRAGQNFLATYGTIPSYRGGKPGLPLRYNNQQLRIVKDKNEPSDFAVQALAYEQKNEQKKQHHPPPSVTQSQVSQVRNEITCNVLQVGNWEYAKDAPSQIDPKLGFTSYFADYRQGRVIFGRREAKIIFGDVRSIQHRIDIPYHDCRDIILGTSTEPTVSFTLHVAPKLYELDALQERDDLSALLAQMSAASLNRSIPPMSFQHIGKKFRVSSINTRHAQVVGQCFVYRIALLDGSKLSRIRDLVSRSGKCTVLALKTGVTNSKEPMDKSFTRLNHELSDQGRYGSRPFQLLYQVDRLARNGFLPPDKVLALLPMISRIHKAHGLAQTVAGLRLLSRNLPLPGPDTEAQDFSLESLEELLEEYVACYDAFAPDNPYELAKRYSHINLIHRVVVTPTGIRLEGPEPEPTNRVLRLHAQNTDNFVRMVFQDEDGGRVKFDWSSDYQRIYHERFQGILDKGITIAGKSFTFLGFSHSSLRSQSCWFMAPFVKAGSLMFAEKVIKELGNFSGIRTPAKCAARIGQNFTDTNTSVRLQRDQVFELAEVVRNGHDFADGAGTISKGLLEEVWKVYGTKRMLKPTALQIRFQGAKGMVAQDTRLPGKRLMLRNNMRKYLTGADDHMDLEICGAAFRPLPMILNRGFIKILEDLAVPEQSFINLQNKAMERLRMMTQSAINTGTLLDEVHTSKASGLPSLIRYLGQIGLDYHHDDFLYAAVELAVISELRDIKHRGRIPVPKGVTLFGVPDETGYLKEGEIFVITERGPTGGKEILVRDKVIITRSPALHPGDIQLAKAVDVPPGNSNRQLSNVVVFSKWGQRDLPSKLSGGDLDGDLYNVIWDETLIPWMIYAPAQYPRVPPVELPRDVTRKDMSDFFVTFMENDKLGLIANQHLQLADQRPMGTLDPDCIKLAALASTAVDYSKTGIPANMGTAPRPAKFKPDYMAPNPRVVFSQEGLLDLEDEDFAPDEAFDTIDAERRPMRYYESQKVLGILYRSIDERQFLADMQRGHRLAVTAHSRHDLMPELLQYVVHTATVTYGGNLYKHHKEFARQIRNSFEESMTNLMYDCEPTPHKPLSETEVFAGQILGRQNGPDGKMLRELSEVMRGRFEKIVEYCNMRITYGDDQMEEVDDLDDLYGAEYSNREVEALPRAIACLEVAVREPGYKDPWVGELVSFKYIAAAAALKELDRYRVTTYASYAGLPPLASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M3AZH1</accession>
    <name>M3AZH1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyltransferase family 20 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_149441</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the trehalose phosphatase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456264">
        <property type="protein sequence ID" value="EMF12902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761023.1">
        <property type="nucleotide sequence ID" value="XM_016905551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3AZH1"/>
    <dbReference type="STRING" id="692275.M3AZH1"/>
    <dbReference type="GeneID" id="27902688"/>
    <dbReference type="eggNOG" id="KOG1050">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002351_3_0_1"/>
    <dbReference type="OMA" id="VHPMPIE"/>
    <dbReference type="OrthoDB" id="755951at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005946">
        <property type="term" value="C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01627">
        <property type="entry name" value="HAD_TPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1020:FF:000003">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase subunit Tps2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000036">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase subunit Tps2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000131">
        <property type="entry name" value="Trehalose-6-phosphate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1020">
        <property type="entry name" value="Trehalose-6-phosphate phosphatase related protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00685">
        <property type="entry name" value="T6PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF123">
        <property type="entry name" value="TREHALOSE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF12902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="956" mass="107112" checksum="3AF0087E4AEF8F5D" modified="2013-05-01" version="1">MSNSNHASAERLDTNLPAHLREDITSIPVTPSEESYSRPSTGSGHPPRHILEAVGADRPQEYFADRAGSANAPRGAHQAATGARTGEDLLRRLSLTGSQSKPDLGGIDPRTAHPGLGLSGNIISATFAVPYKVGYTASGEWELKSRRGTSALFDSFSWLASEESPWKHTLVGWTGEIDRVFHRKDDDHSAGTNGITSMDSIPLNKQSAPIPVHRGDKAPQPTDVAELHVPLADRRKLEKKLEMAAGGHVSPVWLWDEIDKEEVATFRDQSRWRRYAEHELFTLFHYKQNEPSDGRDLRKTWADYYLLNKAFAEAIINVYTPGDIILIHDYHLLLLPSLLRQRLPNVYIGFFLHVPFPSSEYYRCLTRRKEILEGVLGSNMIGFQAYSYARHFSSCCTRILGFDSSSAGVDAYGAHVPVDVFPIGINAEATIKTAFESPDVDLKMQSLREQYQGKQIIVGRDRLDTVRGVAQKLQAFEIFLERHPDMHDKVVLIQVTSPTSIEDRDDKGDKTANKISELVARINGTYGSLSFTPVQHYPQYLSEDEYFALLRIADLGLITSVRDGMNTTALEYVACQRDFHGPLIISEFSGTAGCLADAIHINPWDLGGTADEIYAALQMGEAEKRQQHQLLYQHVTQNTVQHWTTSYIKRLLTNLASYDQSFATPVLDRAKLLQQYRNSTRRLFMFDYDGTLTPIVRDPNAAIPSDKVIRSLKTLASDPLNQVWIISGRDQAFLDEWMGHISELGLSAEHGSFMRPPNSSEWENLTVTLDMSWQSEVMRVFNHYSERTQGSFIERKKIALTWHYRRADPEYGAFMARECQKHLQNTVAKEWEVEVMTGKANLEVRPRFVNKGEIAKRLVREYGEATHEAPDFVLCAGDDFTDEDMFRTLRQSKLPEGHRFAVTVGAKTKQTLASWHLLEPSDVISCIGLLNGSVDAGNAGAVAAVDGAIPDSRPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M3B152</accession>
    <name>M3B152_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH-ubiquinone oxidoreductase 9.5 kDa subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_125256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456263">
        <property type="protein sequence ID" value="EMF13492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016761613.1">
        <property type="nucleotide sequence ID" value="XM_016901966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B152"/>
    <dbReference type="STRING" id="692275.M3B152"/>
    <dbReference type="GeneID" id="27899103"/>
    <dbReference type="eggNOG" id="ENOG502S74C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_166990_0_1_1"/>
    <dbReference type="OMA" id="EKPAIFW"/>
    <dbReference type="OrthoDB" id="2093409at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22903">
        <property type="entry name" value="NI9M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039961">
        <property type="entry name" value="Nuo9.5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38488">
        <property type="entry name" value="OXIDOREDUCTASE 9.5 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G08980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38488:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 9.5 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G08980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF13492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="75" mass="8397" checksum="9F03DABE50D1E356" modified="2013-05-01" version="1">MAPVTFWQAPGTWIHYMARRKPALFWSVVVGSLGPVSMLVVPPIRRRLGDGPRNQIPLTYPIPKGKRVIPAGYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M3B2U1</accession>
    <name>M3B2U1_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SEPMUDRAFT_147931</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762223.1">
        <property type="nucleotide sequence ID" value="XM_016904604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B2U1"/>
    <dbReference type="GeneID" id="27901741"/>
    <dbReference type="eggNOG" id="ENOG502R98C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1235498_0_0_1"/>
    <dbReference type="OMA" id="STDETHD"/>
    <dbReference type="OrthoDB" id="4775599at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004031293" evidence="3">
        <location>
            <begin position="24"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EMF14102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="234" mass="25962" checksum="A9450C7AF93BDA4D" modified="2013-05-01" version="1">MDVVLRLLLGICLASSAFTTAQSTDDGSNLVSSIYGGDSTTTASDISTALPTSANGSDNHNDDDHRDVGGLVNYYFVFLALFVIITGLGAFMMYRRKKRAMLMYRHGQSNALQQDVHQWDPTRARRRHWQGRWRSTDETHDDRERNEGLNEHGEAPPPYMPKGRNDEEALHDHAGQGLAVPLETLSREQAGLKPPGYEYAVTEQYGENMNTGATSSTTITSEEAHRTGSAPQYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M3B2Y3</accession>
    <name>M3B2Y3_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ketol-acid reductoisomerase, mitochondrial</fullName>
            <ecNumber evidence="13">1.1.1.86</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Acetohydroxy-acid reductoisomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Alpha-keto-beta-hydroxylacyl reductoisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SEPMUDRAFT_147955</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">SO2202</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (2S)-2-acetolactate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22068"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-ethyl-2-hydroxy-3-oxobutanoate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13493"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49256"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13 14">Belongs to the ketol-acid reductoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.86" evidence="13"/>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762273.1">
        <property type="nucleotide sequence ID" value="XM_016904620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B2Y3"/>
    <dbReference type="STRING" id="692275.M3B2Y3"/>
    <dbReference type="GeneID" id="27901757"/>
    <dbReference type="eggNOG" id="ENOG502QQBF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033821_1_2_1"/>
    <dbReference type="OMA" id="RAMFSWL"/>
    <dbReference type="OrthoDB" id="10255643at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00056"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004455">
        <property type="term" value="F:ketol-acid reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000003">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000005">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000167">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013023">
        <property type="entry name" value="KARI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000506">
        <property type="entry name" value="KARI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013116">
        <property type="entry name" value="KARI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016207">
        <property type="entry name" value="KetolA_reductoisomerase_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00465">
        <property type="entry name" value="ilvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371">
        <property type="entry name" value="KETOL-ACID REDUCTOISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371:SF1">
        <property type="entry name" value="KETOL-ACID REDUCTOISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01450">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07991">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000119">
        <property type="entry name" value="Ilv5_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51851">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51850">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12 13 14" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="17" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 13 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 13" id="KW-0521">NADP</keyword>
    <keyword evidence="10 13 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="KARI N-terminal Rossmann" evidence="15">
        <location>
            <begin position="65"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="KARI C-terminal knotted" evidence="16">
        <location>
            <begin position="255"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR000119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EMF14152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="403" mass="44801" checksum="02D9F73947AAB587" modified="2013-05-01" version="1">MASKNASRALRASLRQLKAPEVQRRTFITAVNSAKQGVRSAPKAATSAIVHQTRGKKTVDFAGDKEVVYERADWPREKLLDYFKNDTLALIGYGSQGHGQGLNLRDNGLNVIVGVRKGGASWKEATQDGWVEGKNLFDIDEAISKGTIIMNLLSDAAQSETWPHIKPQLTKGKTLYFSHGFSPVFKDQTKVEVPSDIDVILVAPKGSGRTVRTLFREGRGINSSVAVWQDVTGKAEEKAIALGVAVGSGYMYKTTFEKEVYSDLYGERGCLMGGIHGMFLAQYEVLRENGHSPSEAFNETVEEATQSLYPLIGANGMDYMYAACSTTARRGAIDWSKRFKEALKPVFDDLYDSVKTGKETQRTMEYAGRPDYRQAFEKEMEEIRELEIWRAGKAVRSLRPENQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2023-02-22" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>M3B423</accession>
    <name>M3B423_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SEPMUDRAFT_148213</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456262">
        <property type="protein sequence ID" value="EMF14522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016762643.1">
        <property type="nucleotide sequence ID" value="XM_016904779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B423"/>
    <dbReference type="GeneID" id="27901916"/>
    <dbReference type="HOGENOM" id="CLU_2759430_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EMF14522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="70" mass="7607" checksum="1979B6A2AA05215E" modified="2013-05-01" version="1">MAVLINQISSVETGADACHTLFKPIGIRSFKGSNNASDAYFLGVDLNSTSSMPLHHMAPDRGLLRMQCLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M3B6D5</accession>
    <name>M3B6D5_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SEPMUDRAFT_131063</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016763478.1">
        <property type="nucleotide sequence ID" value="XM_016902393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B6D5"/>
    <dbReference type="GeneID" id="27899530"/>
    <dbReference type="HOGENOM" id="CLU_1054369_0_0_1"/>
    <dbReference type="OrthoDB" id="3638344at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EMF15357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <sequence length="264" mass="29095" checksum="3B8C70ADF43E9EF6" modified="2013-05-01" version="1">MAKLTKGPSKTIVTIIVATVIVISVFVCAAVACSLVRRHKRNKRNAQVLKAHLRGGGDEEHEIVEFMKSGSFEAMRHERLGLADNNKTQPSELGYTTRPWHELPRTLLPGQANTSLPTYRPTMADLPKAELADTSIVELPPARSDQKLVPTPLNFSRPSRDNARLKCDGEVHELPEEPQQGSIPTIAGMERHDPNRISSPTVPTLIRHEEDSSESGIEERSSPVSPLTVGNSVRGEKDRPRRVSFASDVSHLRPMEMQGVPSPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M3B7Z9</accession>
    <name>M3B7Z9_SPHMS</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycine zipper 2TM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SEPMUDRAFT_106140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SO2202</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB456261">
        <property type="protein sequence ID" value="EMF15957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016764078.1">
        <property type="nucleotide sequence ID" value="XM_016900616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3B7Z9"/>
    <dbReference type="STRING" id="692275.M3B7Z9"/>
    <dbReference type="GeneID" id="27897753"/>
    <dbReference type="eggNOG" id="ENOG502S756">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_824194_0_0_1"/>
    <dbReference type="OMA" id="AWIAHEV"/>
    <dbReference type="OrthoDB" id="3649111at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37014">
        <property type="entry name" value="EXPRESSION LETHALITY PROTEIN HEL10, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37014:SF10">
        <property type="entry name" value="RICH PROTEIN MS8, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05650)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EMF15957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="39210" checksum="786C54B1EA566DC4" modified="2013-05-01" version="1">MSCDFNSYSRSAGGGPARGQGHTGHYYYSTNHPEASDSLDDHRYESVPRPPREPGYVPYEDTYNSRDAGQAGEDYSSSSFFSPFPPPPRDQFSPRPDSFNQMAPYDDNKAYAQEQDAWQQDHQQRAYMQNRPPPSAVAAGYGRGGRRSEDSYDDRYYDDDSEYDDDDRRRRTRRSYQDRRRIRRYSNDDSITEKALRYPSDPKKGGRDFFGASEGERGLGANLAGLAAGGFLGNKFGKGGAISTLGGAVVGAIAAQAAERQYAKRKEEKVFVRRSMGDPYAVPAGPYPQRGRDMDDVRESQRDVDKPVGFREKMRSLSRRAMARTRSRSRPARRSSSVESVEQDHYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M3BPG9</accession>
    <name>M3BPG9_SPHMS</name>
    <protein>
        <submittedName>
            <fullName evidence="11">t-SNARE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SEPMUDRAFT_152357</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sphaerulina musiva (strain SO2202)</name>
        <name type="common">Poplar stem canker fungus</name>
        <name type="synonym">Septoria musiva</name>
        <dbReference type="NCBI Taxonomy" id="692275"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Sphaerulina</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SO2202</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB456272">
        <property type="protein sequence ID" value="EMF08063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_016756184.1">
        <property type="nucleotide sequence ID" value="XM_016907395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M3BPG9"/>
    <dbReference type="STRING" id="692275.M3BPG9"/>
    <dbReference type="GeneID" id="27904532"/>
    <dbReference type="eggNOG" id="KOG0812">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044998_0_1_1"/>
    <dbReference type="OMA" id="EHNHNVV"/>
    <dbReference type="OrthoDB" id="421009at2759"/>
    <dbReference type="Proteomes" id="UP000016931">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090083">
        <property type="term" value="P:regulation of inclusion body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference 
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